United States
                      Environmental Protection
                      Agency
                       Prevention, Pesticides
                       And Toxic Substances
                       (7508W)
EPA-738-F-93-006
September 1993
£EPA   R.E.D.   FACTS
          Pesticide
     Reregistration
                      Boric  Acid
     All pesticides sold or used in the United States must be registered by
EPA, based on scientific studies showing that tiiey can be used without
posing unreasonable risks to people or the environment. Because of
advances in scientific knowledge, the law requires that pesticides which
were first registered years ago be reregistered to ensure that they meet
today's more stringent standards.
     In evaluating pesticides for reregistration, EPA obtains and reviews a
complete set of studies from pesticide producers, describing the human
health and environmental effects of each pesticide.  The Agency imposes
any regulatory controls that are needed to effectively manage each
pesticide's risks.  EPA then reregisters pesticides that can be used without
posing undue hazards to human health or the environment.
     When a pesticide is eligible for reregistration, EPA announces this
and explains why in a Reregistration Eligibility Decision (RED) document.
This feet sheet summarizes the information in the RED document for boric
acid and its sodium salts, which includes the seven active ingredients boric
acid, sodium tetraborate  decahydrate (borax decahydrate), sodium
tetraborate pentahydrate (borax pentahydrate), sodium tetraborate
(anhydrous borax), disodium octaborate tetrahydrate, disodium octaborate
(anhydrous), and  sodium metaborate.
        Use Profile
     Pesticide products containing boric acid and its sodium salts are
registered in the U.S. for use as insecticides, fungicides and herbicides.
As insecticides, some act as stomach poisons in ants, cockroaches,
silverfish and termites, while others abrade the exoskeletons of insects. As
herbicides, some cause desiccation or interrupt photosynthesis in plants,
while others suppress algae in swimming pools and sewage systems.  As
fungicides, several are wood preservatives which control decay-producing
fungi in lumber and timber products.
     Boric acid and its sodium salts are used on several agricultural and
many non-agricultural sites including residential, commercial, medical,
veterinary, industrial, forestry and food/feed handling areas.  They are
marketed in many formulations including liquids, soluble and emulsifiable
concentrates,  granulars, powders, dusts, pellets,  tablets, solids, paste,
baits, and crystalline rods.

-------
                         The quantities of boric acid and its sodium salts applied as pesticides
                    are modest compared to amounts used for other, non-pesticidal purposes.
                    Further, boric acid, borax and boron-containing salts are ubiquitous in the
                    environment.  Boron occurs naturally in water, fruits, vegetables and
                    forage crops, and is an essential nutrient for plants as well as an essential
                    element for many organisms.

    Regulatory        Boric acid was first registered as a pesticide in the U.S. in 1948.
        History   Currently, 189 pesticide products are registered which contain boric acid or
                    one of its sodium salts as an active ingredient.
                         In February  1986, EPA issued  two related documents dated
                    November 1985, the "Boric Acid and Boron Containing Salts Registration
                    Standard" (NTIS #PB87-101903),  and a General Registration Standard
                    entitled, "Guidance for the Registration and Reregistration of End-Use
                    Pesticide Products Containing the Insecticidal Uses of Boric Acid."  About
                    43 boric acid products, used indoors for cockroach and silverfish control,
                    were reregistered under the  General Registration Standard.  Producers of
                    those products need only submit current labels and Confidential Statements
                    of Formula for the  products to remain reregistered.
                         EPA has determined that, because they are of low toxicity and occur
                    naturally, boric acid and its  sodium salts should be exempted from the
                    requirement of a tolerance (maximum residue limit) for all raw agricultural
                    commodities.  The Agency has established such exemptions and removed
                    the previously established tolerances  for residues of boric acid and certain
                    derivatives in cotton seed and citrus  fruits (please see 58 FR 44282); two
                    other derivatives will be similarly  exempted soon.  Because boric acid is
                    registered for crack and crevice use in food and feed handling
                    establishments, the potential exists, though unlitely, for residues to occur
                    in food.  EPA therefore is establishing food and feed additive tolerances
                    for boric acid and its sodium salts.
                         In developing this RED, the  active ingredient sodium metaborate was
                    added from another reregistration case.  Also, this RED originally was to
                    have included boric oxide as an active ingredient.  However, since no
                    registered products currently contain that active ingredient,  it is not
                    included.
Human  Health
  Assessment
Human Toxicity
     The toxicity of boric acid and its six sodium salts are expected to be
similar. Information on the effects of these boron-related compounds in
humans, supplemented by data from laboratory animal studies, were used
by EPA to evaluate their toxicity.
     Boric acid generally is of moderate acute toxicity, and has been
placed in Toxicity Category III for most acute effects including oral and

-------
dermal toxicity, and eye and skin irritation.  Sodium tetraborate (anhydrous
borax) products have been placed in Toxicity Category I indicating a high
degree of acute toxicity for eye irritation effects.
      A subchronic borax feeding  study using dogs resulted in blood and
metabolism disorders as well as effects to the testes, endocrine system,
brain weight, and size ratios among various organs and glands.
     In chronic oncogenicity studies using mice, rats and beagle dogs,
boric acid and borax were found not to be carcinogenic; however,
testicular effects and decreases in body weight resulted at high dose levels.
EPA has classified boric acid as a "Group E" carcinogen, indicating that it
shows "evidence of noncarcinogenicity" for humans.
     In reproductive and developmental toxicity studies using  rats, mice
and rabbits, maternal liver and kidney eifects and decreased weight gain as
well as decreased fetal body weights were observed.  In two studies, at the
highest dose levels, no litters were  produced. Prenatal mortality occurred
at the highest dose levels in the rabbit study.  Boric acid does not cause
mutagenicity.
Dietary Exposure
     Tolerances were established for residues of boron resulting from the
use of boric acid and its sodium salts on cottonseed (30 ppm) and cirrus
fruits, postharvest (8 ppm)  (please  see 40 CFR 180.271.)  EPA's review of
new toxicology studies raised no concerns. Further, boron occurs naturally
hi fruits and vegetables at much higher levels (200 to 300 ppm in red
cabbage).  Therefore, the Agency is exempting these compounds from the
requirement of a tolerance and revoking die existing tolerances. EPA is
establishing food/feed additive regulations to cover the use of boric acid
salts for crack and crevice treatments at food and feed handling
establishments (please  see 58 PR 44282,  and a soon-to-be-issued Federal
Register notice).
Occupational and Residential Exposure
      Boric acid and its sodium salts are applied both indoors and outdoors,
in residential, commercial, medical,  veterinary and industrial areas, in food
handling establishments, in swimming pools and sewage systems, in lakes,
ponds and reservoirs, and in treating wood.  Depending on the use site,
boric acid  may be applied using aircraft,  a spreader, airblower, power
duster, squeeze applicator, aerosol  can or knife/spatula. The potential for
dermal and inhalation exposure exists among applicators and people
reentering  treated areas.
      As a prudent measure to reduce any potential risks to handlers, EPA
is requiring that all products containing boric acid  and its sodium salts
(except products for residential use) bear personal protective equipment
(PPE) requirements.  These must consist of at least the use of a long-
sleeved shut, long pants, shoes, socks and chemical-resistant gloves.  If

-------
                    end-use product labeling already bears PPE requirements that are more
                    protective than these items, the more protective requirements must be
                    retained.
                         The Worker Protection Standard (WPS) for Agricultural Pesticides
                    (40 CFR 156 and 170) established an interim restricted-entry interval (REI)
                    of 12 hours for boric acid and its sodium salts.  EPA is retaining this REI
                    for uses within the scope of the WPS, as a prudent risk mitigation measure
                    to protect workers. During the REI, workers may  enter treated areas only
                    under the few narrow exceptions allowed in the WPS.
                    Human Risk Assessment
                         Dietary risk is not a concern with boric acid and its sodium salts
                    since no direct food uses are registered and tolerances have been revoked.
                    Applicators and others hi treatment areas may be exposed to boric acid and
                    its sodium salts during or after application.  However, there is no
                    reasonable expectation that these pesticide uses may constitute  a hazard or
                    risk to people involved in, or near to, handling or application activities.
                    Proper care and adhering ID label directions and precautions should reduce
                    exposure and any associated risk.


Environmental   Environmental  Fate
  Assessment        No new environmental fete data are required for reregistration of
                    boric acid and its sodium salts because only relatively small amounts of
                    boric acid are used as pesticides, and significant amounts of boron are
                    present naturally in soil  and water.  Surface soil contains relatively high
                    levels of boron.  Boron salts occur naturally in low concentrations in most
                    unpolluted waterways (both surface water and seawater).  In some areas,
                    boron occurs in surface  waters hi concentrations that have been shown to
                    be toxic to commercially important plants.
                    Ecological Effects
                         Available studies indicate that technical boric acid is practically
                    nontoxic to birds, fish and aquatic invertebrates, and relatively nontoxic to
                    beneficial insects.  The boric acid rights-of-way herbicide use pattern poses
                    a potential risk to aquatic invertebrates, including some that are
                    endangered.  However, risk probably is mitigated by the  practice of
                    limiting treatment to  small strips of land, thereby limiting the amount of
                    contaminated runoff into adjacent aquatic environments.
                         Boric acid's noncrop herbicidal use also may harm endangered or
                    threatened plants.  EPA  is requiring three phytotoxicity studies (seed
                    germination, seedling emergence and vegetative vigor) to assess these
                    risks. EPA is deferring  endangered species labeling requirements until the
                    Agency publishes the Endangered  Species Protection Program plan and
                    guidance for registrants. Labeling will refer users to county bulletins for
                    area-specific use limitations.

-------
                        Ecological Effects Risk Assessment
                             EPA's concerns regarding risks to birds, fish and wildlife species are
                        minimal.  Boric acid's limited outdoor use patterns, low toxicity, and
                        natural presence in terrestrial and aquatic  environments are mitigating
                        factors for any potential risk to nontarget organisms.

   Additional Data        EPA is requiring three phytotoxicity studies to further assess the risks
           Required   of boric acid and its sodium salts to non-target plants and endangered plant
                        species.  However, these studies are not part of the target data hase and do
                        not affect the reregistration eligibility of boric acid and related active
                        ingredients.  The Agency also is requiring product-specific data including
                        product chemistry, acute toxicity and efficacy studies, revised Confidential
                        Statements of Formula, and revised product labeling for reregistration.
                             EPA already has reregistered all 43 boric acid products covered by
                        the General Registration Standard.  For these products, only current
                        labeling and Confidential Statement of Formulas must be submitted to
                        ensure that they still meet the criteria set forth in that document.

  Product Labeling        The labeling of all end-use products containing boric acid and its
Changes Required   sodium salts must comply with EPA's current pesticide labeling
                        requirements.  In addition:
                        •   Compliance with Worker Protection Standard (WPS) - Any product
                        whose labeling permits use in the production of an agricultural plant on any
                        farm, forest, nursery or greenhouse must  comply with the labeling require-
                        ments of:
                             • PR Notice 93-7, "Labeling Revisions Required by the Worker
                             Protection Standard (WPS),"  and
                             • PR Notice 93-11, "Supplemental Guidance for PR Notice 93-7."
                        Unless specifically directed in the RED, all statements required by these
                        two PR Notices must appear on product labeling exactly as instructed in
                        the Notices.   Labels must be revised by April 21, 1994, for products
                        distributed or  sold by the primary registrant or supplementally registered
                        distributors,  and by October 23, 1995, for products distributed or sold by
                        anyone.
                        •   Personal Protective Equipment (PPE) Requirements
                             Products NOT Primarily Intended for Home Use
                             The PPE requirement for handlers of all end-use products except
                             those intended primarily for home use is:
                              "Applicators and other handlers must wear:
                                   -Long-sleeved shirt and long  pants
                                   —Chemical-resistant or  waterproof gloves*
                                   —Shoes plus socks

-------
     * The glove statement is that established through the instructions in
     Supplement Three of PR Notice 93-7."
     Registrants must compare the PPE requirements in this section with
     those on then- product labeling, and retain the more protective PPE,

     No new PPE requirements need to be added.  However, any PPE
     requirements on current product labeling must be retained.
•  Entry Restrictions
     Products NOT Primarily  Intended for Home Use
     0  Uses Within the Scope of the WPS:  A 12-hour restricted entry
     interval (REI) is required for all uses within the scope of the WPS,
     except on products intended primarily for home use.  The PPE for
     early entry should be that required for applicators  of boric acid and
     its sodium salts, except that the requirement for an apron or
     respirator is waived.  Registrants should insert this REI and PPE into
     the standardized statements required by PR Notice 93-7.
          • Sole Active  Ingredient Products:  Must be revised to adopt
          the entry restrictions set forth in this section, and any
          conflicting entry restrictions on current labeling must be
          removed.
          • Multiple Active Ingredient Products:  Registrants must
          compare the entry restrictions set forth hi this section to the
          entry restrictions on their current labeling and retain those
          which are more protective.   A specific time period in hours or
          days is considered more protective than "until sprays have
          dried" or "dusts have settled."
     o  Uses Not Within the Scope of the WPS:  No new entry restrictions
     must be added.  However, any entry restrictions on current product
     labeling must be retained.
     Products Primarily Intended for Home Use
     No new entry restrictions need to be added.  However, any entry
     restrictions on current product labeling must be retained.
•  Products Under the General Boric Acid Registration  Standard
     Labels must comply  with the format labels issued  with the Standard.
Five copies of current labeling must be submitted.
•  Products Not Under the General Registration Standard
     Labels must bear the following Environmental Hazards statements, if
appropriate:
     0  Terrestrial Food and Feed Use  and Non-Crop Products
           "Do not apply  directly to water, or to areas where surface
          water  is present or  to tntertidal areas below the  mean high-

-------
                          water mark.  Do not contaminate water when disposing of
                          equipment washwaters or rinsate."
                     0  Indoor Use Products with Effluent
                          "Do not discharge effluent containing this product into lakes,
                          streams, ponds, estuaries, oceans or other waters unless in
                          accordance with the requirements of a National Pollutant Dis-
                          charge Elimination System (NPDES) permit and the permitting
                          authority has been notified hi writing prior to discharge. Do
                          not discharge effluent containing this product to sewer systems
                          without previously notifying the sewage treatment plant
                          authority.  For guidance, contact your State Water Board or
                          Regional Office of the EPA."
                     Labels with uses on carpets and floors to combat fleas, cockroaches,
                ants and silverfish must bear the following under Directions for Use:
                     o  Use Restrictions
                          "Children and pets should not be in treatment area until after
                          application is completed. Do not treat pets with this  product.
                          Avoid contamination of feed and foodstuff. Avoid
                          contamination of ornamental plants."
                     o  Carpets
                          "Apply to dry surfaces only.  Apply directly on carpets where
                          pets frequently traffic or sleep.  Work powder deeply  into
                          fibers and mat widi a broom or rug rake. Any powder visible
                          after application must be brushed into carpet fibers or
                          removed."
                     0  Upholstery
                          "Remove loose cushions. Apply along creases and into corners
                          and furniture wells.  Do not apply product to exposed fabric.
                          Any product visible after application must be removed."

Regulatory        The use of currently registered pesticide products containing boric
Conclusion   ac^ ^^ lt& sodium salts in accordance with approved labeling will not
                pose unreasonable risks or adverse effects to humans or the environment.
                Therefore, all uses of these products are eligible for reregistration.  These
                products will be reregistered once  the required product-specific data,
                Confidential Statements of Formula and revised labeling are received and
                accepted by EPA.
                     Boric acid products that already have been reregistered under the
                General Registration Standard will remain reregistered as long as current
                labeling and Confidential Statements of Formula are submitted, and demon-
                strate that these products still  meet die criteria set forth in the Standard.

-------
                      Boric acid products which also contain other active ingredients will
                be reregistered only after the other active ingredients are determined to be
                eligible for reregistration.

   For More        EPA is requesting public comments on the Reregistration Eligibility
Information  Decision (RED) document for boric acid and its sodium salts during a 60-
                day time period, as announced in a Notice of Availability published hi the
                Federal Register. To obtain a copy of the RED document or to submit
                written comments, please contact the Pesticide Docket, Public Response
                and Program Resources Branch, Field Operations Division (7506C), Office
                of Pesticide Programs (OPP), US EPA, Washington, DC 20460, telephone
                703-305-5805.
                      Following the comment period,  the boric acid RED document will be
                available from the National Technical  Information Service (NTIS), 5285
                Port Royal Road, Springfield, VA 22161, telephone 703-487^650.
                      For more information about EPA's pesticide reregistration program,
                the boric acid  and its sodium salts RED, or reregistration of individual
                products containing these active ingredients, please contact the Special
                Review and Reregistration Division (7508W), OPP, US EPA, Washington,
                DC 20460, telephone 703-308-8000.
                      For information about the  health effects of pesticides, or for
                assistance hi recognizing  and managing pesticide poisoning symptoms,
                please contact the National Pesticides Telecommunications Network
                (NPTN).  Call toll-free 1-800-858-7378, between 8:00 am and 6:00 pm
                Central Tune,  Monday through Friday.

-------
    REREGISTRATION ELIGIBILITY DOCUMENT

           BORIC  ACID AHD ITS SOD I DM SALTS
                      BORIC ACID
 SODIUM TETRABORATE DECAHYDRATE (BORAX DECAHYDRATE)
SODIUM TETRABORATE PENTAHYDRATE (BORAX PENTAHYDRATE)
        SODIUM TETRABORATE (ANHYDROUS BORAX)
           DISODIUM OCTABORATE TETRAHYDRATE
           DISODIUM OCTABORATE  (ANHYDROUS)
                   SODIUM METABORATE

                        LIST A

                      CASE 0024
                 ENVIROKMENTAL-PKOrECnON-AGENCV
                   OinCE-OF-PESTICIDE'PROCRAMS
              SPECIAL-REVTEW.ANI>-RISEGISTTIAT!ON-DIV1SION

-------

-------
                        TABLE OF CONTENTS


BORIC ACID REREGISTRATION ELIGIBILITY TEAM  	iii

GLOSSARY OF TERMS AND ABBREVIATIONS  	   v

EXECUTIVE SUMMARY	  vii

I.     INTRODUCTION	   1

n.    CASE OVERVIEW	   2
      A.    CHEMICAL OVERVDZW  	   2
      B.    USE PROFILE  	   5
      C.    ESTIMATED USAGE OF PESTICIDE	   17
      D.    DATA REQUIREMENTS	   17
      E.    REGULATORY HISTORY  	   18

m.   SCIENCE ASSESSMENT	   19
      A,    Physical Chemistry Assessment	   19
      B.    Human Health Assessment	  22
           1.     Toxicology Assessment  	  22
                 a.    Acute Toxicity	  22
                 b.    Subchronic Toxicity	  24
                 c.    Chronic Toxicity/Oncogenicity	  24
                 d.    Reproductive and Developmental Toxicity  	  25
                 e.    Mutagenicity	  26
                 f.    Metabolism	  26
                 g.    Reference Dose/Carcinogenicity	  26
           2.     Exposure Assessment  	  27
                 a.    Dietary	  27
                 b.    Occupational and Residential	  28
           3.     Risk Characterization	  29
      C.    Environmental Assessment	  29
           1.     Environmental Fate	  29
           2.     Ecological Effects  .	  30
                 a.    Terrestrial Data	  30
                 b.    Aquatic Data	  31
                 c.    Beneficial Insects' Data  	  3'
                 d.    Effects on Plants  Data	
                 e.    Endangered Species Concern	

IV.   RISK MANAGEMENT AND REREGISTRATION DECISION	
      A.    Determination of Eligibility	
           1.     Eligibility Decision	
           2.     Eligible and Ineligible Uses  	

-------
      B.    Regulatory Position	   34
            1.     Tolerance Reassessment	   34

V.    ACTIONS REQUIRED BY REGISTRANTS	   36
      A.    Manufacturing-Use Products	   36
            1.     Generic Data Requirements	   36
            2.     Labeling  	   37
      B.    End-Use Products	   38
            1.     Product-Specific Data Requirements   	   38
                   a.     Products Under the General Registration Standard for
                         Boric Acid	   38
                   b.     Products Under the Boric Acid and Boron Containing
                         Salts Registration Standard	   38
                   c.     Products not included in either Boric Acid Standards  . .   39
            2.     Labeling  	   39
                   a.     Compliance with the Worker Protection Standard  ....   39
                   b.     Compliance with the Existing Stocks Provision  	   41
                   c.     Products Under the General Boric Acid Standard  ....   42
                   d.     Products Not Under General Boric Acid Standard  ....   42

VL   APPENDICES

      Appendix A-  Use Patterns Subject to Reregistration

      Appendix B-  Table of the Generic Data Requirements and Studies Used to Make the
                   Reregistration Decision

      Appendix C-  Citations Considered to be Part of the Data Base Supporting the
                   Reregistration of Boric Acid and its Sodium Salts

      Appendix D-  List of Available Related Documents

      Appendix E-  Combined Generic and Product Specific Data Call-in Notice

            Attachment 1 -      Data Call-In Chemical Status Sheet
            Attachment 2 -      Generic Data Call-in and Product Specific Data Call-In
                               Response Forms with Instructions
            Attachment 3 -      Generic Data Call-In and Product Specific Data Call-In
                               Requirements Status and Registrants' Response Forms
                               with Instructions
            Attachment 4 -      EPA Grouping of End-Use products for Meeting Acute
                               Toxicology Data Requirements for Reregistration
            Attachment 5 -      EPA Acceptance Criteria
            Attachment 6 -      List of Registrants Receiving this Notice
            Attachment 7 -      Cost Share and Data Compensation Forms and
                               Confidential Statement of Formula Form with  Instructions
                                        11

-------
BORIC ACID REREGISTRAHON ELIGIBILITY TEAM

Office of Pesticide Programs:

Biological and Economic Analysis Division
Dave Thomas
William Gross
Mel Crystal
Yvette Hopkins
Phyllis Johnson
Margaret Cogdell
Gabe Patrick
Steve Jaiboe
Biological Analysis Branch
Biological Analysis Branch
Biological Analysis Branch
Economic Analysis Branch
LUIS, Biological Analysis Branch
LUIS, Biological Analysis Branch
LUIS, Biological Analysis Branch
LUIS, Biological Analysis Branch
Environmental Fate and Effects Division
Mary Frankenberry
John Noles
Brinson Connerly-Perks

Health EffectsJDivision

Jane Smith
Randolph Perfetti
Melba Morrow
Judy Smith

Registration Division

Shyam Mathur
Ian Blackwell
Daniel Peacock
Rame Cromwell
Karen P. Hicks
Science Analysis and Coordination Staff
Ecological Effects Branch
Environmental Fate and Groundwater Branch
Chemical Coordination Branch
Chemistry Branch n
Toxicology Branch n
Occupational and Residential Exposure Branch
Registration Support Branch
Registration Support Branch
Insecticide-Rodenticide Branch
Insecticide-Rodenticide Branch
Fungicide-Herbicide Branch
Policy and Special Projects Staff

Jean Frane                Special Review and Registration Section

Office of General Counsel

Bob Perlis
Laurel Celeste
                                        111

-------
Special Review and Registration Division
Linda Propst               Reregistiation Branch
Mario  Fiol                 Reregistration Branch
                                           iv

-------
a.i.

CAS
     GLOSSARY OF TERMS AND ABBREVIATIONS

Active Ingredient

Chemical Abstracts Service
COMMODITY CHEMICAL       Is a chemical that may have many uses such as a
                                feedstock used in the production process for other
                                chemicals and/or final non-pesticidal uses.  Some of
                                these chemicals may have pesticidal uses.

CSF         Confidential Statement of Formula

EEC         Estimated Environmental Concentration. The estimated pesticide concentration
             in an environment, such as a terrestrial ecosystem.

EP          End-Use Product

EPA         U.S. Environmental Protection Agency

FIFRA       Federal Insecticide, Fungicide, and Rodenticide Act

FFDCA      Federal Food, Drag, and Cosmetic Act

HDT         Highest Dose Tested

             Median Lethal Concentration.  A statistically derived concentration of a
             substance that can be expected to cause death in 50% of test animals- It is
             usually expressed as the weight of substance per weight or volume of water or
             feed, e.g., mg/1 orppm.

             Median Lethal Dose. A statistically derived single dose that can be expected
             to cause death in 50% of the test animals when administered by the route
             indicated (oral,  dermal). It is expressed as a weight of substance per unit
             weight of animal, e.g., mg/kg.

LD,,,         Lethal Dose-low. Lowest Dose at which lethality occurs

LEL         Lowest Effect Level

LOEL       Lowest Observed Effect Level
MATC
Maximum Allowable Toxicant Concentration

-------
              GLOSSARY OF TERMS AND ABBREVIATIONS (cent.)

MICRONUTRIENT A nutrient that plants require in only small or trace amounts.

MP          Manufacturing-Use Product

MPI         Maximum Permissible Intake

MRID       Master Record Identification (number).  EPA's system of recording and
             tracking studies submitted.

N/A         Not Applicable

NPDES      National Pollutant Discharge Elimination System

NOEL       No Observed Effect Level

OPP         Office of Pesticide Programs

PADI        Provisional Acceptable Daily Intake

ppm         Parts Per Million

RAC         Raw Agricultural Commodity

RED         Reregistration Eligibility Decision Document

RfD         Reference Dose

RS          Registration Standard

TD          Toxic Dose. The dose at which a substance produces a toxic effect.

TC          Toxic Concentration. The dose at which a substance
             produces a toxic effect.

TMRC       Theoretical Maximum Residue Contribution
                                        VI

-------
EXECUTIVE SUMMARY

       This Reregistration Eligibility Decision document (RED) addresses the eligibility for
reregistration of pesticide products containing boric acid and its sodium salts; specifically it
includes products containing boric acid, sodium tetraborate decahydrate (borax decahydrate),
sodium tetraborate pentahydrate (borax pentahydrate), sodium tetraborate (anhydrous borax),
disodium octaborate tetrahydrate, disodium octaborate (anhydrous), and sodium inelaborate.
Hereafter, in this document, this group of chemical compounds will be referred to as "boric
acid and its sodium salts."

       Boric  acid and its sodium salts are acaricides, algaecides, fungicides, herbicides, and
insecticides used on a variety of agricultural, non-agricultural, residential, commercial,
medical, industrial, and food/feed handling sites. Boric acid  and its sodium salts are
formulated in a number of ways.  Uses for boric acid include those for direct application to
food and feed.

       The first boric acid pesticide product was registered in 1948.  Currently, there are
189 products containing boric acid or related compounds that are subject to this RED.  In
February 1986, the Agency issued two registration standards, the Boric Acid and Boron
Containing Salts Registration Standard (NTIS PB87-101903) and a General Registration
Standard, entitled Guidance for the Registration and Reregistration of Bid-Use Pesticide
Products Containing the Insecticidal Uses of Boric Acid. Both documents were dated
November  1985, but not issued until February 1986.  The Agency issued minor revisions to
both documents in April 1986.

       This RED includes hi the reregistration case sodium metaborate which was initially
grouped in a  different registration standard but it is included here because this chemical is a
sodium salt of boric acid.  Originally, this RED was to have  included boric oxide as an
active ingredient.  However, since there currently are no registered products with this active,
boric oxide will not be included in this document.

       The Agency has classified boric acid and its sodium salts as a Group E carcinogen
(evidence of non-carcinogenicity for humans). A reference dose for the boron equivalents of
boric acid and borax was calculated to be 0.09 mg/kg/day based on a no observable effect
level (NOEL) of 8.80 mg/kg/day in a. combined sub-chronic  (38 weeks) and chronic (two
years)  study in dogs.  An uncertainty factor of 100 accounts for inter-species extrapolation
and intra-species variability.

       Boron occurs naturally in water, fruits, vegetables, and forage crops, and is an
essential nutrient for plants.  Based on the review of the lexicological data base and because
boric acid occurs naturally, with little if any residues of boron expected above endogenous
levels, the  Agency determined that boric acid and its sodium  salts should be exempted from
the requirement of a tolerance  on all raw agricultural commodities. Therefore,  on August
20, 1993 the Agency established exemptions from the requirement of a tolerance for residues

                                         vii

-------
of boric acid and certain derivatives on all raw agricultural commodities and removed
previously established tolerances in cotton seed and citrus fruits (58 FR 44282),  The Agency
will issue a federal register notice proposing to amend the exemption from tolerances to
include the two derivatives,  sodium tetraborate pentahydrate (borax pentahydrate) and
disodium  octaborate  (anhydrous), omitted in the original notice.  Also, because products
containing boric acid salts are registered for crack and crevice use in food and feed handling
establishments, the potential exists, even though unlikely, for residues to occur in food.
Therefore, the Agency is establishing food and feed additive regulations for boric acid and its
sodium salts in food and feed handling establishments.

       There is minimal concern for risk to  fish and wildlife based on the limited outdoor
use patterns,  low toxicity, and boron's natural occurrence in terrestrial and aquatic
environments.  However, in order to further assess the potential risks to non-target plants
and to endangered plant species, the Agency is requiring three phytotoxicity studies.  These
requirements are not part of the target data base and do  not affect the reregistration eligibility
of boric acid and its sodium salts.

       The Agency has determined that the uses of boric acid and its sodium salts will not
cause unreasonable risk to humans or the environment and  all of the uses are eligible for
reregistration.

       Unlike products covered by the Boric Acid and Boron Containing Salts Registration
Standard, the Agency has already reregistered all boric acid products used only for domestic
and nondomestic indoor use for cockroach and silverfish control which were covered by the
General Boric Acid Standard. For these products, the only requirement imposed by  this
RED is the submission of a current label and CSF to insure that each product is still in
compliance with  its special certification form submitted  earlier.

       Before reregistering the products containing boric acid and its sodium salts, the
Agency is requiring  the submittal or citation of product  specific data: product chemistry,
acute toxicity, and efficacy (if needed), a revised Confidential Statement of Formula (CSF),
and revised labeling within eight months of  the issuance of this document  After these data
and revised labels have been reviewed and determined to be acceptable, the Agency  will
reregister a product  based on whether or not it meets the requirements in Section 3(c)(5) of
FIFRA.   Those products containing more than one active ingredient will be eligible for
reregistration only when the other active ingredients are determined to be eligible for
reregistration.
                                          Vlll

-------
I.     INTRODUCTION

       In 1988, the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) was
amended to accelerate the reregistration of products with active ingredients registered prior to
November 1, 1984. The amended Act provides a schedule for the reregistration process to be
completed in nine years.  There are five phases to the reregistration process. The first four
phases of the process focus on identification of data requirements to support the reregistration
of an active ingredient and  the generation and submission of data to fulfill the requirements.
The fifth phase is a review  by the U.S. Environmental Protection Agency (referred to as "the
Agency") of all data submitted to support reregistration.

       FIFRA Section 4(g)(2)(A) states that in Phase 5 "the Administrator shall determine
whether pesticides containing such active ingredient are eligible for registration" before
calling in data on products  and either reregistering products or taking "other appropriate
regulatory action." Thus, reregistration involves a thorough review of the scientific data base
underlying a pesticide's registration. The purpose of the Agency's review is to reassess the
potential hazards arising from the currently registered uses of the pesticide; to determine the
need for additional data on health and environmental  effects; and to determine whether the
pesticide meets the "no unreasonable adverse effects" criterion of FIFRA.

       This document presents the Agency's decision regarding the reregistration eligibility
of the registered uses of boric acid and its sodium salts. The document consists of six
sections. Section I is the  introduction. Section n describes boric acid and its sodium salts,
their uses, data requirements  and regulatory history. Section HI discusses the human health
and environmental assessment based on the data available to the Agency.  Section IV presents
the reregistration decision for boric acid and its  sodium salts. Section V discusses the
reregistration requirements. Finally, Section VI is the Appendices which support this RED.
Additional details concerning the Agency's review of applicable data are available on
request.1
       1      EPA's reviews of data on the set of registered uses considered for EPA's
analysis may be obtained from the OPP Public Docket, Field Operations Division (H7506C),
Office of Pesticide Programs, EPA, Washington, DC 20460.

-------
H.    CASE OVERVIEW

      A.    CHEMICAL OVERVIEW2

            The following active ingredients) are covered by this Reregistration Eligibility
      Decision:

      (1) boric acid

            Chemical Name: boric acid
            CAS Registry Number:  10043-35-3
            OFF Chemical Code:  011001
            Empirical Formula: HjB03
            Basic Manufacturer:  U. S. Borax


      (2) sodium tetraborate decahvdrate (borax decahy drate)

            Chemical Name: sodium tetraborate decahydrate (Borax 10 Mol)
            CAS Registry Number:  1303-96-4
            OPP Chemical Code:  011102
            Empirical Formula: Na^G,. 10H2O
            Basic manufacturer:  U.S. Borax


      (3,) sndium tetraborate pentahvdrate (borax pentahydrate)

            Chemical Name: Sodium tetraborate pentahydrate (Borax 5 Mol)
            CAS Registry Number:  11130-12-4 or 12179-04-3
            OPP Chemical Code:  011110
            Empirical Formula: NajB+Oy
            Basic Manufacturer:  U.S. Borax
             The November 1985 Registration Standard reviewed the data requirements for
             registered products containing boric acid and boron containing salts (borax and
             disodium octaborate tetrahydrate). Since there are no longer active products
             containing boric oxide, this document will not assess the data requirements for
             boric oxide.

-------
(4) sodium tetraborate (anhydrous borax)

      Chemical Name:  sodium tetraborate (Anhydrous Borax)
      CAS Registry Number: 1330-43-4
      OPP Chemical Code:  011112
      Empirical Formula: Na2B407
      Basic Manufacturer: U.S. Borax
(5) disodimn octaborate tetrahydrate

      Chemical Name: disodium octaborate tetrahydrate
      Trade Name:  Polybor* 3
      CAS Registry No.:  12008-41-2
      OPP Chemical Code:  011103
      Molecular Formula:  Na.BA.,. 4H:O
      Basic Manufacturer: US Borax
(6) disftdiiim nftaborate (anhydrous)

      Chemical Name: Timber Rods
      CAS Registry Number:  12008-41-2
      OPP Chemical Code:  011107
      Empirical Formula: Na^BgO^
      Basic Manufacturer: Chemical Specialties
(7) sodium inelaborate

      Chemical Names:  sodium metaborate
      CAS Registry No.:  15293-77-3
      OFF Chemical Code:  011104
      Empirical Formula: NaBO2
      Basic Manufacturer: US Borax and J. R. Simple* Co.

-------
     The table below lists the active ingredients and additional names by which the
chemicals are known.
           ACTIVE INGREDIENT AND ADDITIONAL NAMES
                                FOR
                     BORIC ACID AND ITS SALTS

""- 	 Aetivfe Ingredient ;; ;,/;- ; .;.;;;..;; 7 7 ;;;•
boric acid
sodium tetraborate decahydrate
sodium tetraborate peotahydrate
sodium tetraborate anhydrous
disodium octaborate (anhydrous)
disodium octaborate tetrahydrate
sodium metaborate
boric oxide

Additional Name(s)
boracid acid
orthoboric acid
disodium tetraborate decahydrate
sodium borate decahydrate
borax decahydrate
sodium biborate lOHjO
sodium pyroborate lOHjO
disodium tetraborate pentahydrate
borax pentahydrate
sodium borate pentahydrate
sodium biborate 5H2O
sodium pyroborate 5H2O
disodium tetraborate (anhydrous)
borax (anhydrous)
sodium borate (anhydrous)
sodium biborate (anhydrous)
sodium pyroborate (anhydrous)
none
none
none
boric anhydride
boron oxide
boron trioxide
boron sesquioxide

-------
       B.    USE PROFILE

       The following is a general use profile for the registered uses for boric acid and its
sodium salts, A detailed table of eligible uses as well as the methods, application rates,
limitations, and use restrictions is included in Appendix A.

A)     Chemical:  boric acid
       Type of Pesticide:  Acaricide, Algaecide, Fungicide, Herbicide, Insecticide

       Mechanism of Action:
             (Plants):     At herbicide quantities, boric acid causes plant desiccation.
             (Fungi):      Inhibits the growth of fungi by preventing the production of
                          conidia or asexual spores.
             (Insects):     Acts as a stomach poison against ants, cockroaches, silverfish,
                          and termites.

       Use Groups And Sites
             AQUATIC NON-FOOD INDUSTRIAL
             Sewage systems,

             TERRESTRIAL FOOD+FEED
             Agricultural crops/ soils  (unspecified), orchards (unspecified).

             TERRESTRIAL NON-FOOD CROP
             Agricultural uncultivated areas, commercial/institutional/industrial
             premises/equipment (outdoor), golf course turf, nonagricultural rights-of-
             way/fencerows/hedgerows, nonagricultural uncultivated areas/soils, ornamental
             lawns and turf recreational areas, refuse/solid waste sites (outdoor),  wood
             protection treatment to forest products (seasoned).

             INDOOR FOOD
             Barns, barnyards/auction barns, commercial transportation facilities (feed/food
             empty), eating establishments, food handling areas (food contact), eating
             establishments food serving areas (food contact),  food processing plant
             nonfood handling areas, food processing plant premises (nonfood contact),
             food/grocery/marketing/storage distribution facility premise.
             household/domestic indoor food handling areas, meat processing plant
             premises (nonfood contact), poultry (egg/meat), poultry processing plant
             premises (nonfood contact).

             INDOOR NON-FOOD
             Eating establishments, animal kennels/sleeping quarters (commercial),
             commercial storage/ warehouses premise (indoor), commercial transportation

-------
      facilities (nonfeed/nonfood) commercial/institutionaVindustrial
      premises/equipment (indoor), eating establishments nonfood areas (nonfood
      contact), specialized animals.

      INDOOR MEDICAL
      Hospitals/medical institutions premises (human/veterinary).

      INDOOR RESIDENTIAL
      Household/domestic dwellings, household/domestic dwelling contents,
      household/domestic dwelling indoor premises, pet living/sleeping quarters,
      refuse/solid waste containers (garbage cans), wood protection to
      buildings/products (indoor).

      OUTDOOR RESIDENTIAL
      Household/domestic dwellings outdoor premises, ornamental lawns and turf,
      pet living/sleeping quarters.

Pests: Ants, cockroaches, silverfish, termites and decay producing fungi.

Formulation Types Registered

      Single Active Ingredient Products
             Wettable Powder
                    99.0%
             Dust
                    99.0%, 64.0%, and 65.0%
             Liquid Concentrate
                    26.3%
             Ready-to-Use Paste
                    50.0%
             PeUeted/Tableted
                    40.0%
             Bait Tube
                    53.3%

Method and Rates of Applications

       Several methods of application are used to apply boric acid including fixed-
       wing aircraft, aerosol can, knife or spatula, shaker can, spoon, mop, portable
       line sprayer, pump spray bottle, boat, pressure sprayer, spreader, hand
       application, bulbous dusters, power duster, wood pressure treating equipment
       and ready-to-use paste tube applicators.

-------
      Limitations

             Avoid depositing product onto exposed food and feed processing, preparation
             and serving surfaces, or introducing material into air.  Do not apply when
             food processing facility is in operation.  Any product visible after application
             must be brushed into cracks and crevices, or removed.  Place product in areas
             that are inaccessible to children and pets.

B)    Chemical; sodium jetraboratc decahydrate (011102)

      Type of Pesticide:  Fungicide,  Insecticide, Herbicide,

      Mechanism of Action: Acts as an abrasive on the exoskeleton of insects,  and as a
      stomach poison.  It is also used as a herbicide to control weeds; used as a
      preservative on wood products against decay fungi, and as an algae suppressant in
      swimming pools and sewage systems.

      Use Groups And Sites

             FORESTRY
             Forest tree management/forest pest management (conifer stump treatment)

             TERRESTRIAL NONFOOD CROP
             Ornamental lawns and turf, industrial areas (outdoor), paved areas (private
             roads/sidewalks), wood pressure treatment to forest products, wood protection
             treatment to forest products (unseasoned and seasoned).

             AQUATIC NONFOOD INDUSTRIAL
             Sewage systems.

             AQUATIC NONFOOD OUTDOOR
             Wood protection treatment to aquatic structures/items.

             INDOOR FOOD
             Household domestic dwelling indoor food handling areas  (crack and crevice),
             food processing plant premises feed/food empty, food processing plant
             nonfood handling areas, eating establishments food handling areas (food
             contact),  eating establishments food serving areas (food contact),
             food/grocery/maiketing/storage/ distribution facility premises, commercial
             transportation facilities feed/food empty.

             INDOOR NONFOOD
             Specialized animal housing, animal kennels/sleeping quarters (commercial),
             specialized  animals,  commercial transportation facilities nonfeed/nonfood,

-------
      eating establishments non-food areas (nonfood contact), commercial/
      institutional/industrial premises/equipment (indoor).

      INDOOR MEDICAL
      Hospitals/medical institutions premises (human/veterinary)

      INDOOR RESIDENTIAL
      Household/domestic dwelling indoor premises/contents, wood protection
      treatment to buildings/products indoor.

      OUTDOOR RESIDENTIAL
      Ornamental lawns and turf, household/domestic dwelling outdoor premises,
      wood protection treatment to buildings/products outdoor

Pests: decay and soft rot fungi,  sapstain, molds; wood boring beetles (including
      powderpost beetles, furniture beetles, old house borers and longhorn beetles),
      subterranean termites, dampwood termites, drywood termites, cockroaches,
      sweet-eating ants, grease  eating ants, pavement ants, little black ants, black
      carpenter ants, odorous ants, silverfish, palmettobugs; algae, klamath weed,
      weeds (unspecified).

Formulation Types:

      Single Active Ingredient Products
             Water Soluble Powder
                   100%
             Granular
                   99.5%
             Liquid
                   5.4% and a 4%

      Multiple Active Ingredient Products
             Paste
                   40% + 1 other active ingredient (AI)
             Solid Bait
                   5%  + 1 other active ingredient (AI)
             Liquid
                   2%  + 2 other active ingredients (AI's)

Method and Rates of Application

       The wood preservatives paste is applied by hand using trowel/brush,  caulking
       gun,  or bandage.  Liquid wood preservative is applied using pressure treating
       plants, spray box flow coaters, dip tanks, sprayers or brushes.


                                   8

-------
             The liquid ant bait is dispensed by hand to a cardboard tray and the solid bait
             is marketed in a RTU child resistant bait station.

             The granular herbicide is broadcast by hand using a suitable distribution
             device (preferably a mechanical spreader) at a rate of 10 to 15 lb/100 sq ft, for
             klamath weed the rate may be reduced to 3 to 4 lb/100 sq ft.

             The granules may also be dissolved in water and applied by power sprayer at
             the same rate.

             The granular fungicide is applied to stamps within two days of cutting using a
             granular shaker, one pound will treat 50 sq ft of stump surface.

             The dust/powder is applied using pressurized duster/blower, bulbous duster or
             other suitable dusting equipment.   For exterior use the dust is applied at 8
             lb/3,000 sq ft.

             The rates of borax applied to some sites are unclear and not identified.
             Therefore,  they cannot be accurately reported in this profile.

      Use Limitations

             Wood Preservative Paste - do not drill holes in utility poles closer than two
             feet.

             Ant Baits - avoid contamination of feed and foodstuffs.

             Dust/Powder - not to be used in food areas of food handling establishments
             other than as crack and crevice treatment and after treatment any surface
             powder must be brushed into cracks and crevices or removed.  Only to be
             applied to areas inaccessible to children.

             Herbicide  Spray or Granules - non-selective and therefore can only be used
             in areas where vegetation is not wanted, if weed growth is heavy cut
             vegetation before treatment.

C)    Chemical:  sodium  tetraborate pentahydrate (011110)

      Type of chemical: Algaecide, Herbicide, Insecticide

      Mechanism of Action:  Acts as an abrasive on the exoskeleton of insects and as a
      stomach poison.  It is also used as a herbicide to control weeds & in swimming pools
      to suppress algal growth. In field crops, it is used to correct or prevent boron
      deficiencies.

-------
Use groups and sites:

       TERRESTRIAL NONFOOD CROP
       Nonagricultural uncultivated areas/soils, industrial areas (outdoor), paved areas
       (private roads/sidewalks).

       AQUATIC NONFOOD RESIDENTIAL
       Swimming pool water systems.

       INDOOR FOOD
       Household/domestic dwellings indoor food handling areas, commercial
       transportation facilities (feed/food-empty),  food processing plant premises
       (non-food contact), food processing plant nonfood handling areas,  eating
       establishments food handling/serving areas (food contact),
       food/grocery/marketing/stoiage/distribution facility premise.

       INDOOR NONFOOD
       Commercial transportation facilities (non feed/ nonfood), eating establishments
       nonfood areas (nonfood contact) commerciaVinstitutional/industrial premises/
       equipment (indoor).

       INDOOR MEDICAL
       Hospitals/medical institutions premises (human/ veterinary).

       INDOOR RESIDENTIAL
       Household/domestic dwellings indoor premises.

 Pests: algae, klamath weed,  poison ivy, leafy spurge, Canada thistle, wild morning
       glory, wild oats, ryegrass, johnsongrass, poison oak; cockroaches, ants,
       silverfish

 Formulation types:
       Single Active Ingredient Products
             Granular
                    96%
             Dust
                    74%
             Soluble concentrate/solid
                    99.5%

       Multiple Active Ingredient Products
                    38% + 2 other active ingredients
                                   10

-------
       Methods and rates of application:

             Granular - In fall, winter, or when needed, broadcast, apply spot or
             prepaying treatment by spreader, granule applicator, or hand at 0.2-13 Ib
             AI/100 sq ft.

             Dust - When needed, apply indoor general surface, voids, crack & crevice, or
             spot treatment by squeeze applicator, duster, or bulbous duster using ready-to-
             apply dust.

             Soluble concentrate/solid - Initially & for subsequent, maintenance, or
             winterizing treatment, apply at 1 Ib AI/1,000 gal pool water.

       Use limitations:
             Do not contaminate lawns, trees, shrubs, crops,  & other desirable plants. Do
             not contaminate water,  feed, or foodstuffs. Do not use  in edible product areas
             of food handling establishments.

D)     Chemical;  sodium tetraborate (011112)

       Type of chemical: Acaricide, Herbicide, Insecticide

       Mechanism of Action:     Acts as an abrasive on the  exoskeleton of insects and as a
                                 stomach poison.  Used as a herbicide to control weeds.

       Use Groups and Sites:

             TERRESTRIAL NONFOOD CROP
             Nonagricultural rigbts-of-way/fencerows/ hedgerows, industrial areas
             (outdoor), agricultural uncultivated areas/soils, recreational areas,  paved areas
             (private roads/sidewalks),  commercial/institutionaiy industrial
             premises/equipment (outdoor).

             INDOOR RESIDENTIAL
             Ornamental herbaceous plants, ornamental woody shrubs & vines, ornamental
             &/or shade trees, ornamental nonflowering plants.

       Pests: Powder post beetles, furniture beetles, old house borers, longhorn beetles,
             ants, mealy bugs, spider mites, aphids, scale insects; bioadleaf weeds, grasses

       Formulation  Types:
             Single Active Ingredient Products
                    Emulsifiable concentrate
                           0.28%

                                          11

-------
             Granular
                    100%
             Bait/liquid ready to use
                    5%

      Multiple Active Ingredient Products
             Soluble concentrate/liquid
                    11.41%  + 1 other active ingredient (AI)

Methods and Rates of Application:

      Emulsifiable concentrate - Apply foliar spray with sprayer at 3 tsp of 0.28%
      product/pi water.

      Granular - In fall, winter, or when needed, broadcast or apply spot treatment
      by spreader or hand using 2.7 to 11 Ib AI/100 sq ft.  When needed, apply
      prepaying treatment at 5 Ib AI/100 sq ft.

      Liquid ready-to-use - When  needed, apply few drops of 5 %  product along ant
      trails and small amount in cracks & crevices.

      Soluble concentrate/liquid -  Apply with power or knapsack sprayer.  The
      rates of sodium tetraborate cannot be calculated in terms of AI from the label
      and,  therefore are not reported in this profile.

Use limitations

      Do not deposit product over exposed surfaces.  Do no contaminate water,
      food, or food processing surfaces or surfaces likely to be contacted by food.
      Do not contaminate lawns, trees, shrubs, crops, and other desirable plants.



Type of Pesticide:  Fungicide, insecticide

Mechanism of action:      Acts as an abrasive on the exoskeleton of Insects and as
                          a stomach poison,  used as a fungicide on wood products
                          to control decay fungi

Use groups and sites:

       TERRESTRIAL FOOD + FEED CROP
       Compost/compost piles, manure
                                    12

-------
      TERRESTRIAL NONFOOD CROP
      Animal kennels/sleeping quarters (commercial), refuse/solid waste sites
      (outdoor), wood pressure treatment to forest products.

      AQUATIC NONFOOD INDUSTRIAL
      Sewage systems.

      AQUATIC NONFOOD OUTDOOR
      Wood protection to aquatic structures/items.

      OUTDOOR RESIDENTIAL
      Wood protection treatment to buildings/products outdoor

      INDOOR FOOD
      Food/grocery/marketing/storage/distribution facility premise, poultry
      (egg/meat).

      INDOOR NONFOOD
      Commercial storages/warehouses premises (indoor), eating establishments food
      handling  & serving areas (nonfood contact), commercial/institutional/industrial
      premises/equipment.

      INDOOR MEDICAL
      Hospitals/medical institutions premises (human/ veterinary).

      INDOOR RESIDENTIAL
      Household/domestic dwellings and contents, wood protection treatment to
      buildings/products indoor, pet living/sleeping quarters

Pests: brown rot, fungal decay, white rot, wood rot/decay fungi; ants, cockroaches,
      fleas, house fly, soldier fly, latrine fly, silverfish, termites, wood boring
      insects

Formulation types:
      Single Active Ingredient Products
             Soluble concentrate/liquid
                   40% (includes 1 product for manufacturing use)
             Soluble concentrate/solid
                   99.4%
             Formulation not identified/solid
                   98%
                                  13

-------
      Methods and rates of application:

             Soluble concentrate/solid
                   Use when needed.  Apply compost or manure treatment by dust gun or
                   hand at 20 Ib active ingredient (AI)/1,000 ft2. Spray at 44 Ib AI/1,000
                   ft3. Sprinkle at 20 to 49 Ib AI/1,000 ft1.  Apply wood protection
                   treatment by pressure or by dip-diffusion in tank at 140 to 380 Ib
                   AI/100 gal solution.  Apply nonsoil contact nonfumigation with sprayer
                   or brush at 6.5 to 29 Ib AI/1,000 fl? or by tank or injection at  1 to 3.75
                   Ib AI/  gal solution.  Mop at 0.25 Ib Al/gal solution.  Apply indoor
                   premise treatment by carpet shampooer at 2 to 3.3 Ib AI/1,000 ft2.

             Soluble concentrate/liquid
                   Use when needed.  Apply nonsoil contact nonfumigation by sprayer,
                   brush,  or injection using maximum rate (23 % solution) for protection
                   from subterranean and Formosan termites.

      Use limitations:

             Do not use in edible product areas of food processing plants or on counter tops
             and other surface areas where food is prepared.  Do not use in serving areas
             while food is  exposed.  Do not contaminate feed, water, or food. Do not use
             to treat lumber that will contact soil or be exposed to leaching by weather.

F)    Chemical:  disndium octahorate (anhydrous) (011107)

      Type of chemical: Fungicide

      Mechanism of action:     Used to prevent and control decay fungi in lumber and
                                timber products.

      Use groups and sites:

             TERRESTRIAL, NONFOOD CROP
             Wood protection treatment to forest products (seasoned and unseasoned).

             OUTDOOR RESIDENTIAL
             Wood protection treatment to buildings/products outdoor.

             INDOOR RESIDENTIAL
             Wood protection treatment to buildings/products indoor.

       Pests: decay fungi.
                                         14

-------
      Formulation types:
             Crystalline rod
                    100%

      Methods and rates of application:

      Rods are inserted into holes drilled to appropriate size and sealed with wooden
      dowels,  wood filler or caulk.  For remedial treatment the rate is 4.14 oz (6.0 oz boric
      acid equivalent) per cubic foot of wood, and for preventative treatment the rate is
      1.38 oz  (2.0 oz boric acid equivalent) per cubic foot of wood,

      Use limitations:
      None.

G)    Chemical;  sodium metaborate (011104)

      Type of Chemical:  Herbicide

      Mechanism of Action:     Sodium metaborate is taken up by plant roots. Once it
                                 enters the leaves, it interrupts the photosynthetic
                                 pathway; thereby, causing the plant to die.

      Use groups and sites:

             TERRESTRIAL NON-FOOD CROP
             Agricultural uncultivated areas, airports/landing fields, industrial areas
             (outdoor), nonagricultural outdoor buildings/structures, nonagricultural rights
             of way/fencerows/hedgerows, nonagricultural uncultivated areas/soils,
             nonagricultural uncultivated soil sterilization, and recreational areas.

             AQUATIC NON-FOOD INDUSTRIAL
             Drainage systems (ditch banks).

             OUTDOOR RESIDENTIAL
             Paths/patios, paved areas (private roads/sidewalks), nonagricultural rights-of-
             way/fencerows/hedgerows.

      Pests:  Sand burr, poison ivy, poison oak, bermudagrss, bindweed, bluegrass, Canada
      thistle, crabgrass,  daUisgrass, downy brome, smooth brome, dock, wild carrot, sweet
      clover, sheep sorrel, dandelion, plantain, bouncingbet, goldenrod, asters, daisies,
      dogbane, field bindweed, horsenettle, johnsongrass, kochia, leafy spurge, nutsedge,
      paragrass, Russian knapweed, Russian thistle, sunflower, whitetop, and willow.
                                          15

-------
Formulation types

      Multiple Active Ingredient Products
             Granular
             94.0% + 1 active ingredient (AT).
             68.0% + 1 active ingredient (AI).
             66.5% 4- 2 active ingredients (ATs)
             55.6% + 2 active ingredients (ATs)
             54.0% + 1 active ingredient (AI).
             50.0% + 2 active ingredients (AI's).
      Pellet ed/tableted
             50.0% + 3 active ingredients (AI's).
      Fonnulation not identified/solid
             50.0% + 1 active ingredient (AI)
      Soluble concentrate/liquid
             19.0% + 1 active ingredient (AI).
             10.0% + 1 active ingredient (AI).
             10.0% + 2 active ingredients (AI's).
             9.08% + 1 active ingredient (AI).
             9.0% + 1 active ingredient (AI).
             8.75% +2 active ingredients (AI's).
             6.0% + 1 active ingredient (AI).
             4.57% + 1 active ingredient (AI).
      Ready-to-use liquid
             10.0% + 1 active ingredient (AI).

Method and rates of application

      Granular soil treatment-When needed, broadcast by power spreader, at 35-
      376 Ibs Al/acre.

      PeUeted/tableted-When needed, broadcast by spreader or shaker can at 200
      Ibs Al/acre.

      Formulation not identified/solid-Use as broadcast treatment when needed at
      436 Ibs Al/acre.

       Soluble concentrate/liquid-When needed, apply by hand sprayer, sprinkler
       can, or power sprayer.  Maximum rates vary with the formulation and weeds
       to be controlled, rates range from 148.8 to 543.6 Ibs AI/A.

       Liquid ready-to-use-When needed, apply by edging treatment to lawn, apply
       with squeeze applicator at 0.0512 Lb AI/100 linear feet,
                                   16

-------
       Use limitations

       Sodium inelaborate is not selective and may be toxic to all types of vegetation.  It
       may render the entire area totally or partially unproductive for one or more years.
       Take care to confine application to the particular area intended to be treated and
       prevent its contact with lawns, trees, shrubs, crops and other desirable plants which
       are not intended to be destroyed or injured. This includes precautions in treating
       areas which may be underlaid by roots of adjacent valuable plants.  Do not drain or
       flush equipment near these areas.
       C.    ESTIMATED USAGE OF PESTICIDE

       This section presents information on the pesticide uses of boric acid and its sodium
salts.  The estimates provided are derived from a variety of published and proprietary
sources available to the Agency. The data, reported on an aggregate and site (crop) basis,
reflect annual fluctuations in use patterns as well as the variability in using data from various
information sources.

       Data from the US Bureau of Mines (1989-1991) report "agricultural uses" of boron
minerals  averaged 133 metric tons (293,265 Ibs.) per year.  The pesticide uses are believed
to be  smaller in volume than the agricultural uses.  However, data from the late 1970*s early
1980's suggest a much greater usage of boric acid.

        Additionally, no technical product is registered for sodium metaborate.  Historically,
there  has been moderate usage of sodium metaborate on rights-of-way, railroads and
industrial sites.  It is reported that wood preservative uses are second in volume to insecticide
uses.
       D.    DATA REQUIREMENTS

       Data requested in the Boric Acid and Boron Containing Salts Registration Standard
covered product chemistry, ecological and environmental effects, toxicology and residue
chemistry studies for manufacture and end-use products containing boric acid and two sodium
salts, sodium tetraborate decahydrate (borax decahydrate),  and disodium octaborate
tetrahydrate.  Appendix B of this document identifies the generic data that the Agency
reviewed as part of its determination of reregistration eligibility of boric acid and its sodium
salts and lists the acceptable studies.
                                           17

-------
       E.    REGULATORY HISTORY

       Borate is the accepted common name for the metal salts of boric acid which comprise
the following family of chemicals:  sodium tetraborate decahydrate, sodium tetraborate
pentahydrate, sodium tetraborate (anhydrous borax), disodium octaborate (anhydrous),
disodium octaborate tetrahydrate, and sodium metaborate.

       The first boric acid product was registered as a pesticide in 1948.  In February 1986,
the Agency issued two registration  standards, dated November 1985, for products containing
boric acid and related compounds.  The EPA issued minor revisions to both documents hi
April 1986.

       The Boric Acid and Boron Containing Salts  Registration Standard covered technical
and end-use products containing boric acid and and two sodium salts, sodium tetraborate
decahydrate (borax decahydrate), and disodium octaborate tetrahydrate.  This standard
required submission of certain forms; revised labeling; and additional product and residue
chemistry, environmental and ecological effects, toxicology and efficacy data.

       The Agency  also published the General Registration Standard, Guidance for the
Registration and Reregistration of End-Use Pesticide Products Containing the Insecticidal
Uses of Boric Acid.  This document covered only boric acid products of 99 to 100% purity
which were used primarily for cockroach control. Because of the low toxicity  and reduced
risk of such products and the extensive data base available for boric acid in the public
literature, the Agency only required submission  of an application form and a special
Certification Form verify ing the product's adherence to certain specifications concerning
composition,  form, supplier, and labeling.

       Prior to development of the Boric Acid and  Boron Containing Salts Registration
Standard, the Agency had combined under one active ingredient three distinct sodium salts of
boric acid;  sodium tetraborate decahydrate, sodium  tetraborate pentahydrate,  and sodium
tetraborate.  In the same manner, the Agency had also combined under once active ingredient
disodium octaborate decahydrate and disodium octaborate.  During the  development of this
RED, the product chemistry characteristics of each  chemical indicated that each chemical is
unique in its characteristics and that each chemical  should also be uniquely identified.

       Furthermore, another sodium salt of boric acid, sodium metaborate, which is
supported by data from actives included hi the Boric Acid Registration  Standard of 1985, was
not included in the 1985 Registration Standard, but was later assigned to the barium
metaborate case.  Because sodium metaborate is a sodium salt of boric  acid,  the data
supporting boric acid and other sodium salts also supports sodium metaborate.  Therefore,
the Boric Acid Reregistration Eligibility Team decided to include  sodium metaborate hi the
boric acid and its sodium salts reregistration case.
                                          18

-------
       Additionally, the Boric Acid Registration Standard did not include the related
compound boric oxide as one of the active ingredients in the boric acid case. This oversight
was noted in the March 1990 "Reregistration Plan for Chemicals in List A."  At that time
the Agency intended to correct this oversight by including boric oxide during the
^registration of boric acid and its sodium salts.  However, because there are no active
registrations for products containing boric oxide, this RED will not include boric oxide.

       Currently,  there are 189 products containing boric acid or related compounds that
should be subject  to this RED: 121 products subject to the Boric Acid and Boron Containing
Salts Registration  Standard; 43 products subject to the General Boric Acid Standard; and 25
sodium metaborate products not subject to either standard.
m.    SCIENCE ASSESSMENT

       The Agency has conducted a thorough review of the scientific data base for boric acid
and its sodium salts for the purpose of determining the reregistration eligibility of these
pesticides.

       A.    Physical Chemistry Assessment

       The physical and chemical properties of boric acid and its sodium salts are as follows:

       (1)    boric acid

             TGAI:  boric  acid
             Molecular weight: 61.88
             Color:  white
             Physical State:  solid crystalline powder
             Odor: none
             Melting Point:      170.9'C ± 0.20C(340°F) [melts without
                                 decomposition]
             Specific Gravity:  1.5128 at 20°C
             Solubility;    4.72%at20°C
             Vapor Pressure:  less than 10^ torr at 20°C
             Octanol/Water Partition Coefficient:    0.175
             pH: 5.1 (1%  solution at 20°C)
             Stability:  stable

       (2)    sodium tetraborate decahydrate (borax decahydrate)

             TGAI:  sodium tetraborate decahydrate
             Molecular weight: 381.87
             Color:  white

                                          19

-------
      Physical State:  crystalline powder
      Odor:  none
      Melting Point:  62°C (144°F) [begins to dissolve in water of hydration]
      Density:  1.73
      Solubility:  4.70 g/lOOml at 20°C (68«F)
      Vapor Pressure:  < 10~* Torr
      pHi  9.24 (1 % solution)  at 20°C
      Stability: stable

(3)    sodium tetraborate pentahydrate (borax pentahydrate)

      TGAI:  sodium tetraborate pentahydrate
      Molecular Weight:  291.35
      Color:  white
      Physical state: a mild white alkaline salt
      Odor: none
      Melting Point:  < 200°C (with decomposition)
      Density:  1.818
      Solubility:    In water 1.52% (0°C), 3.59% (20°C), 4.43% (25°C), 50.13%
                    (100°C). In organic solvents at 25°C: 16.9% (MeOH), 31.1%
                    (Ethylene glycol).
      Vapor Pressure:  < 10"6 Torr
      pH:   9.26 (0.1% solution); 9.24 (1.0%  solution) and 9.32  (4.71% saturated
             solution) at 20°C
      Stability: stable under ordinary conditions

(4)    sodium tetraborate (anhydrous borax)

      TGAI:  sodium tetraborate (anhydrous borax)
      Molecular Weight:  201.27
      Color:  white
      Physical State:  solid crystalline or  amorphous
      Odor:  none
      Melting Point:  742°C (1367°F)
      Density:  2.367
      Solubility:    It is soluble in water but at much slower rate than regular borax.
                    The solubility of finely divided crystalline disodium tetraborate
                    in methanol and ethylene glycol, expressed as wt
                          % Na^^Oj are 16.7% and 30%  respectively.
      Vapor Pressure:  < 10^ Torr
      pH:  data gap
      Stability:  stable under ordinary conditions
                                   20

-------
(5)     disodium octaborate tetrahvdrate

       Color:  White. Munsell Color: 5.0 Y 9*24/1.25
       Physical State:  Powder
       Odor: None
       Specific gravity(bulk density): 25-35 Ibs/cubic foot
       Solubility:  9.5% at 20°C
       pH:  8.5 (1% solution at 23°C)
       Storage stability:  Stable
       Corrosion Characteristics:  Non-corrosive to steel and most metals.  May be
                                 slightly corrosive to Al.

(6)     disodium octaborate (anhydrous)

       TGAI:  disodium octaborate (anhydrous)
       Molecular Weight:  340.31
       Color:  clear to opaque
       Physical State:  solid rods
       Odor:  odorless
       m.p.: data gap
       Density:  1.8 g/mlat20°C
       Storage Stability: data gap

(7)     sodium metaborate

       TGAI:  sodium metaborate
       Molecular weight:  65.82
       Color:  white
       Physical State:  solid white pieces or powder
       Odor:  none
       Melting Point:      Fuses to clear glass at 966°C (1770T). Some
                          vaporization occurs at 1230°C (2246°F).
       Bulk Density (Tetrahydrate):      loose Pack (51-55 Ibs/fr3) and Tight Pack
                                       (55-61  Ibs/ft3.
       Solubility:    soluble in water, solution being strongly
                    alkaline
       Vapor Pressure: less than 10"6 Torr
       OctanolAVater Partition Coeff:  Data gap
       pH:  11.82 (6% aqueous solution of tetrahydrate)
       Stability:     the crystals will pick up carbon dioxide if exposed to air,
                    forming sodium carbonate and Borax
                                   21

-------
       There are several product chemistry requirements not fully satisfied for boric acid and
its sodium salts.  Although data gaps exist, these requirements are not critical to the
reregistration eligibility decision.  The Agency is requiring additional product chemistry data
at this time to satisfy these data gaps. The requirements and data gaps are presented in
Appendix B.
       B.    Human Health Assessment

             1.     Toxicology Assessment

       Boric Acid and its sodium salts include sodium tetraborate decahydrate, sodium
tetraborate pentahydrate, sodium tetraborate (anhydrous borax), disodium octaborate
(anhydrous), disodium octaborate tetrahydrate, and sodium inelaborate.  The toxicity of all
these boron related chemicals is expected to be similar. At the time of the Registration
Standard, oncogenicity, teratogenicity, as well as a battery of mutagenicity studies were
required.  The information available on the effects of boric acid and its sodium salts in
humans, supplemented with the data available on their toxicity in laboratory animals, is
sufficient to evaluate the toxicity of boric acid and its sodium salts. The laboratory animal
data consist of the following:

                    a.     Acute Toxicity
                     ACUTE TOXICITY VALUES - BORIC ACID

                     TEST                RESULT       CATEGORY

                   Oral IJ350            3.45 g/kg               m

                  Dermal LDjo            > 2 g/kg               HI

                 Inhalation LCi0             —            Not Required
                                          22

-------
      The following table is derived from Manufacturing Use-Products considered
toxicologically similar to the boric acid technical.
                   ACUTE TOXICITY VALUES - BORIC ACID
                   TEST
   RESULT
CATEGORY
                Eye irritation

                Skin irritation

                  Dermal
                Sensitizatkm
 no wmeal opacity,
 conjunctivitis cleared
 erythema present in
1/6 anmuk it 72 hours
     m

     m
Not Required
                          ACUTE TOXICTTY VALUES
                   SODIUM BORATE (ANHYDROUS BORAX)
TEST
OralLD50
Dermal LDJO
Inhalation LCSO
RESULT
4.6 g/kg(M)
> 2 g/kg
not conducted TV/technical
CATEGORY
m
m
Not
Applicable/
Required
                                     23

-------
       The following table is derived from Manufacturing Use Products considered
lexicologically similar to the sodium tetraborate technical.
                             ACUTE TOXTCITY VALUES
                  SODIUM TETRABORATE (ANHYDROUS BORAX)
TEST
Eye irritation
Skin irritation
Dermal
Sensitization
RESULT
irritation and coraeal opacity
evident at Jay 14
no gfcjg irritation
—

CATEGORY
I
IV
Not
Applicable
                    b.    Subchronic Toxicity

       In a subchronic (3 month) feeding study in dogs, borax was tested at doses of 0, 3, 35
or 268 mg/kg/day for males and 0, 2, 22 or 192 mg/kg/day for females. The systemic
NOEL was 35 mg/kg/day for males and 22 mg/kg/day for females, and the LOEL was 268
mg/kg/day and 192 mg/kg/day based on clinical pathology; decreased hematocrit and
hemoglobin; hemosiderin in the spleen;  liver and kidneys; testicular pathology; and,
widening of the adrenal cortex in the area of the zona reticularis.  Lipid accumulation was
also present in the zona reticularis, and  in high dose females, there was an increase in brain
weight.  In males, there were decreases in the testes/brain, testes/body, thyroid/body and
thyroid/brain ratios.   Although this study was classified as supplementary, the information is
considered adequate for use in risk assessment.

                    c.    Chronic Toxicity/Oncogenicity

       A two-year chronic feeding/oncogenicity study using boric acid was conducted with
B6C3F1 mice.  The compound was administered in the diet at levels of 0, 2500 or 5000 ppm
(approximately 0, 450, or 1150 mg/kg/day).  No clinical signs of toxicity were observed
during the course of the study.  Testicular pathology  was present at the highest dose tested
and consisted of testicular atrophy and interstitial cell hyperplasia. Other pathological
findings included a dose related increase (at both levels) in the incidence of splenic lymphoid
depletion in male mice that was believed to be associated with stress and a dose related
increase in the incidence of pulmonary hemorrhage that was of unknown biological
significance. The compound was not found to be carcinogenic at the levels tested.  A NOEL
for systemic toxicity  was not determined; the LOEL for systemic toxicity was 2500 ppm
(approximately 450 mg/kg/day) based on the pathological findings.
                                          24

-------
       A two-year chronic oncogenicity/feeding study with borax was conducted in Sprague
Dawley rats.  Animals received doses of 0, 65,  154 or 515 mg/kg/day during the course of
the study. The chronic NOEL was determined to be 154 mg/kg/day and the LOEL was 515
mg/kg/day based on reported decreases in body  weight, possible anemia and testicular
tubular atrophy.  The test material was not found to be carcinogenic.

       In another study, beagle dogs received borax at doses of 0, 13, 26 or 77 mg/kg/day in
the feed for a duration of two-years.  The NOEL was 77 mg/kg/day (HDT).  An additional
study was conducted for 38 weeks in which beagles received the test material in the feed at
doses of 0 or 359 mg/kg/day. At 359 mg/kg/day, weight decreases were reported for both
sexes,  and in males, testicular atrophy, decreased testicular weight  and decreased testes/body
weight ratios were reported.  Both of these studies were classified as supplementary;
however, the Agency has determined that the information was sufficient for conducting a risk
assessment.

                    d.    Reproductive and Developmental Toxicity

       Pregnant Sprague Dawley rats were administered boric acid in the diet at dose levels
of 0.1%, 0.296, 0.4%,  or 0.8% (approximately 0, 78, 163, 330, or 539  mg/kg/day).  The
test material was administered from day 0 through day 20 of gestation for the three lower
dose levels.  At 0.8%, the compound was administered on gestation days 6 through 20.  The
rationale for providing the test substance for a period that was greater than the period of
organogenesis was to allow the dams to reach a steady state with regard to boric acid
concentrations.  At the highest dose level, exposure to the test material was initiated at a
later period m order to  minimize preimplantation loss and early embryo lethality.  The
maternal NOEL was determined to be  0.1 % (78 mg/kg/day) and the maternal LOEL was
determined to be 0.2%  (163 mg/kg/day) based on increased liver and kidney weights. The
developmental NOEL was 0.1 % (78  mg/kg/day) and the developmental LOEL was 0.2%
(163 mg/kg/day) based on decreased fetal body  weight and the increase in the incidence of
fetuses/Utter with variations (short rib XJH).

       Dose levels of 0, 0.1%, 0.2% or 0.4% (0, 248, 452, or 1003 mg/kg/day) boric acid
were administered to pregnant CD-I  mice in the diet from gestation days 0-17.  A maternal
NOEL was not established; the LOEL for maternal toxicity was 0.1 % (248 mg/kg/day) based
on the increased incidence of dilated renal tubules.  The developmental NOEL was 0.1%
(248 mg/kg/day) and the developmental LOEL was 0.2% (452 mg/kg/day) based on
decreased average fetal body weights.

       Doses of 0, 62.5, 125 or 250 mg/kg/day were administered by gavage to pregnant
New Zealand white rabbits on gestation days 6 through 19, inclusive.  The maternal NOEL
was  125 mg/kg/day and the maternal LOEL was 250 mg/kg/day based on the presence of
vaginal bleeding, decreased weight gain during the treatment period, and decreased gravid
uterine weights that were secondary to prenatal mortality. The developmental NOEL was
125 mg/kg/day and the developmental LOEL was 250 mg/kg/day based on prenatal mortality

                                         25

-------
as characterized by the increase in the total number of resorptions.  At this dose level, there
was also an increase in the incidence of fetuses with enlarged aortas, intraventricular septal
defects and great vessels arising from the right ventricle.  Pre implantation losses were also
higher at 250 mg/kg but this is probably the result of a dosing error since the compound was
supposedly administered after implantation.

      In a two generation reproduction study conducted in mice, boric acid was
administered throughout the study in the diet at levels of 0, 1000, 4500, or 9000 ppm (0,
150, 675 or 1350 mg/kg). The NOEL for parental and reproductive toxicity was 1000 ppm
(150 mg/kg). The parental LOEL was 4500 ppm based on decreases in organ weights in
both sexes.  The reproductive LOEL was also 4500 ppm based on decreased fertility and
decreased pup weight.  At this dose, the average number of days between litters increased
after the second litter and the number of dams producing litters decreased significantly.  At
the highest dose tested, no Utters were produced and the males in this group had a decrease
in sperm concentration and motility when compared to  controls.

      In a reproduction study conducted hi Sprague Dawley rats,  borax was administered in
the feed at doses of 0, 65, 154 or 515 mg/kg/day for three generations. The systemic and
reproductive NOELs were 154  mg/kg/day and the systemic and reproductive LQELs were
515 mg/kg/day.  At this dose level, there was a reported decrease in weight gain during the
pre-mating period hi both sexes and food efficiency  was lower in females. The testes in
males were atrophied and there was a reported decrease in the number of  corpora lutea hi
females at the highest dose tested. Additionally, no litters were produced when high dose
males were mated to high dose females.  When high dose females were mated to control
males, there was a reported decrease in the number of  litters and pup survival was adversely
affected. This study was classified as supplementary, but can be used for risk assessment.

                    e.     Mutagenicity

       Boric acid, has not shown evidence of genetic toxicity. The compound was negative
for gene mutations in both bacteria and mammalian  cells (in vitro).  When administered to
male and female Swiss mice, the results did not show a significant increase in the  frequency
of micronucleated polychromatic erythrocytes in bone marrow cells, i.e.,  chromosomal
aberration (in vivo).

                    f.     Metabolism

       No metabolism  studies are required.

                    g.     Reference Dose/Carcinogenicity

       The OPP/HED RfD Peer Review Committee reviewed  all the toxicologies! data
(previously summarized in this document) and concluded that a Reference Dose (RfD) for the
boron equivalents of boric acid and borax was calculated to be 0,09 mg/kg/day based on 1) a


                                          26

-------
no observable effect level (NOEL) of 8.80 mg/kg/day (as boron equivalents) for testicular
atrophy observed at 29 mg/kg/day (active ingredient) in combined sub-chronic (38 weeks)
and chronic (two years) studies in dogs, and 2) an uncertainty factor of 100 to account for
inter-species extrapolation and intra-species variability.

       The OPP Carcinogenicity Peer Review Committee has classified boric acid as a
"Group E" carcinogen, evidence of non-carcinogenicity for humans.

             2.     Exposure Assessment

                    a.    Dietary

       Tolerances for residues of boron resulting from the use of boric acid and its sodium
salts had been established under (40 CFR 180.271) on cottonseed (30 ppm) and citrus fruits
(8 ppm, postharvest).

       Boric acid and its salts are acaricides, algeacides,  fungicides, herbicides, and
insecticides which are registered for various non-food, agricultural, medical,  and food
handling establishment applications.  Additionally, boron occurs naturally in water, fruits and
vegetables, and forage crops,  and is an essential nutrient for plants.  In pears and
strawberries the levels may reach 160 ppm, and in red cabbage occasionally as high as 200
to 300 ppm.  The increment of added boron residues resulting from pesticide use of boric
acid and the boron-contaioing salts is insignificant compared to levels of naturally occurring
boron in citrus and cottonseed.  For example, lemons average 1 ppm incremental boron due
to treatment, compared witii 2.5 ppm boron which is endogenous.

       The Boric Acid and Boron Containing Salts Registration Standard indicated that the
Agency would consider revoking the existing tolerances and replacing them with an
exemption as well as establishing food additive regulations to cover the food/feed handling
uses at the time the required toxicology studies were submitted  and reviewed.

       Therefore, based on the review of the lexicological data base and because boric acid
occurs naturally with little if any residues of boron expected above endogenous levels, the
Agency has determined that boric acid and its sodium salts should be exempted from the
requirement of a tolerance on all raw agricultural commodities.  Therefore, on August 20,
1993, the Agency established exemptions from the requirement of a tolerance for residues of
boric acid and certain derivatives on all raw and agricultural commodities and removed the
previously established tolerances (in cotton seed and citrus fruits).  The Agency will issue a
federal register  notice proposing to amend the exemption from tolerances to include the two
derivatives, sodium tetraborate pentahydrate (borax pentahydrate) and disodium octaboiate
(anhydrous), omitted in the original notice.  Also, because products of boric acid salts are
registered for crack and crevice use in food and feed handling establishments, and the
                                          27

-------
potential exists, even though unlikely, for residues to occur in food, the Agency is
establishing food and feed additive regulations for boric acid and its sodium salts in food and
feed handling establishments.

       With these actions, there are no residue chemistry data requirements remaining for
boric acid and its sodium salts. The tolerances for residues of boron under 40 CFR 180.271
have been revoked and food and feed additive regulations will be proposed under 40 CFR
185 and  186, respectively.

                    b.     Occupational and Residential

       The products registered for use which contain boric acid as the active ingredient are
applied in aquatic, outdoor and indoor sites (i.e., commercial, industrial, domestic dwellings,
food handling establishments,  sewage systems, wood protection treatment to buildings, etc).
Depending on the use site,  boric acid may be applied using a spreader, fixed-wing aircraft,
knife/spatula, airblower, power duster, squeeze applicator, or aerosol can.  Based on the use
patterns, the potential for dermal and inhalation exposure exists, (i.e., exposure to persons
applying the products, exposure to humans reentering the treated areas, etc.).

       With regards to toxicity, boric acid and its sodium salts are human  poisons by
ingestion.  For boric acid,  death hi infants has resulted from ingestion of less than 5 grams
and adults have died after ingestion of 5 to 20 grams.  Technical grade boric acid is
classified as an acute oral toxicity category m chemical, and an acute dermal toxicity
category El chemical.  Contact involving  concentrated  solutions or nearly pure solid
formulations of boric acid may also produce primary eye irritation;  additionally, dermal
irritation may also occur if accidental contact occurs (i.e. considered toxicity category IV for
primary skin irritation).

       The potential for dermal and inhalation exposure exists.  However, if the products are
used in accordance with the label instructions and considering the lack of toxicological
concern, data are not required for the reregistration of boric acid (and its related
compounds).

       The Agency considers the use of a long-sleeved shirt, long pants, shoes, socks, and
chemical-resistant gloves a prudent risk-mitigation measure to protect handlers from exposure
to boric acid (and its related compounds).  Therefore, the Agency requires that all products
that contain boric acid (and its related compounds) bear personal protective equipment
requirements for handlers that are at least as protective as these items.  If the end-use
product labeling already bears personal protective equipment requirements  that are more
protective than these items, the more protective requirement must be retained.

       The Agency has determined that, at this time, the personal protective equipment
discussed in this section need not apply to residential uses of boric acid (and its related
compounds). The predicted frequency, duration, and degree of exposure in residential uses


                                           28

-------
should not warrant the risk mitigation measures being required for occupational exposed
users.

       The Worker Protection Standard (WPS) for Agricultural Pesticides - 40 CFR Parts
156 and 170 — established an interim restricted-entry interval (RET) of 12 hours for boric
acid (and its related compounds) because the known acute toxicity categories for acute
dermal toxicity, skin irritation potential, eye irritation potential are Toxicity Category HI or
IV.  The Agency considers the 12-hour REI for this chemical a prudent risk-mitigation
measure to protect workers. Therefore, the Agency retains the 12-hour REI for uses within
the scope of the WPS and will allow workers to enter areas treated with boric acid (and its
related compounds) during the REI only in the few narrow exceptions allowed in the WPS.

       The Agency has determined, at this time, the entry restrictions discussed in this
section need NOT apply to uses of boric acid (and its related compounds) not  within the
scope of the Worker Protection Standard for Agricultural Chemicals,  including out-of-scope
commercial uses and homeowner uses. The predicted frequency, duration, and degree of
exposure as a result of such uses should not warrant the risk mitigation measures  being
required for persons engaged in the production of agricultural plants for commercial or
research purposes.

             3.    Risk Characterization

       The human risks associated with boric acid and its salts are known. Ingestion of
boric acid (>5 grams) by (adult) humans is fatal.  There are no direct food application uses
for boric acid and its salts; therefore, there are no dietary concerns based on their current
label uses. There is no reasonable expectation that pesticidal or biocidal uses  may constitute
a hazard or risk to people involved in handling or application activities.  Proper care and
appropriate adherence to label precautions and directions should reduce exposure.  No
additional hazard or exposure data are required for reregistration eligibility.
       C.     Environmental Assessment

       The Agency has determined that no new environmental fate data are required because
of the relatively small amount of boric acid employed for most uses as a pesticide, and the
already significant amounts of boron present in soil and water.

              1.    Environmental Fate

       Boric acid exists in three crystalline forms, with melting points varying from 170 to
200° C.; its solubility in water is 13,000 parts per million.  Dilute aqueous solutions contain
predominantly undissociated H3BO3 molecules, the pK. being 9.14.  The apparent acid
strength of boric acid is increased by strong electrolytes.  In the presence of excess CaCl2 the
strength of boric acid becomes equivalent to that of carboxylic acids.


                                           29

-------
       Boric acid, borax, and boron-containing salts are ubiquitous in the natural
environment.  Available boron occurs in nature in the form of a number of closely related
compounds which differ chiefly in the water of hydration associated with the molecule and
are not easily differentiated. Because of this, the following discussion refers to the group as
"boric acid," "boron," or "the boron salts."  The specie which occurs in solution is the B03*3
cation.  More complex mineral forms containing boron may gradually release it in the form
of borate as a result of weathering. The range of boron as a micronutrient in soil is 5-150
ppm, and representative surface soil contains 50 ppm.  Boron salts occur naturally in low
concentrations in most unpolluted waterways.  A study reviewed by the Agency indicated
that the adsorption and desorption  coefficients  were less than 1.  This study provided
information to confirm that the compound is mobile.   The average concentration for boron in
surface waters has been reported to range from 0.001  mg/liter to 0.1 ing/liter. Seawater
boron concentrations average 4.5 mg/liter.  In some geographical areas such as the American
Southwest, boron occurs in surface waters in concentrations that  have been shown to be toxic
to plants of commercial importance.  Most of the naturally occurring boron is inorganic, but
because it is an essential element for many organisms there is an organically-bound
component.

              2.      Ecological Effects

       The following data and risk assessment summaries are based upon boric acid's limited
outdoor use patterns.  The Agency's concerns  for risks to fish and wildlife species are
minimal.  The limited outdoor use patterns,  low toxicity and boron's natural occurrence in
terrestrial and aquatic environments are mitigating factors for any potential risk to nontarget
organisms.

                     a.     Terrestrial Data

       Five studies reviewed by the Agency provide sufficient information to characterize
technical boric acid as "practically nontoxic" to avian species on an acute oral and dietary
basis. The LD50 value for bobwhite quail is greater than 2510 mg/kg.  The  dietary LC50
value for mallard duck and bobwhite quail are greater than 5620 ppm and 10,000 ppm,
respectively.

       The Agency does not anticipate that avian species will be adversely impacted by the
outdoor use patterns of boric acid. Although the nonagricultuial areas and rights-of-way
require high application rates, certain mitigating factors reduce the risk potential;  i.e., the
infrequent use confined to limited treatment areas and the low avian acute oral and dietary
toxicity minimize any unreasonable exposure risk.  There nave been no  records or
documentation of field mortalities associated with the use of boric acid submitted to the
Agency .

       Three other sites which may require  high treatment rates  are airports/landing fields,
agricultural drainage ditches, and  industrial  drainage ditches. These three sites do not

                                            30

-------
involve large scale acreage similar to agricultural sites. The airport/landing fields use is for
weed control, as needed.  The agricultural and industrial drainage systems' uses are intended
to keep ditchbanks and culverts clear of vegetation, to keep drainages clear of debris, and to
promote rapid drainage.  The Agency does not anticipate that these use patterns will
adversely impact non-target organisms.

                    b.     Aquatic Data

       Four studies reviewed by the Agency provide sufficient information to characterize
technical boric acid as "practically nontoxic" to fish and aquatic invertebrates.  Acute LC50
values for rainbow trout and bluegill sunfish are > 1100 ppm and > 1021 ppm, respectively.
The acute toxicity value (EC50) for the aquatic  invertebrate Daphnia magna ranged from 133
to 226 ppm.  One of the studies reviewed indicated that chronic toxicity value (MATC -
Maximum Allowable Toxicant Concentration) for Daphnia magna is between 6 and 13 ppm.
Therefore, based upon the available acute toxicity data for fish and invertebrates, it was
determined that aquatic invertebrates are more sensitive than fish.

       However, public literature studies indicate that risk to fish and invertebrates from the
outdoor use patterns of boric acid is expected to be minimal because of the low toxicity and
infrequent uses.  Although the rights-of-ways use pattern requires high application rates, the
Agency does not anticipate that aquatic invertebrates will be at risk because of the following
mitigating factors; i.e., boron naturally occurs in surface waters inhabited by both fish and
invertebrates, there  are no official reports in the Agency's  files of field effects of boric acid
on aquatic ecosystems, and the  rights-of-way use pattern is usually limited to treatment of
small strips of land  (e.g., railroad lines, power  lines) thereby limiting the amount of
contaminated runoff into adjacent aquatic environments.

       Additionally, industrial point sources that discharge effluent into surface waters are
subject to NPDES (National Pollutant Discharge Elimination System) permitting process via
the EPA's Office of Water. Label statements for these use patterns require users or
dischargers to contact the EPA  or appropriate state agencies before discharging effluent into
surface waters.

                    c.     Beneficial Insects' Data

       A study reviewed by the Agency provides sufficient information to characterize
technical boric acid as "relatively nontoxic" to beneficial insects.  The honey bee acute
contact LD50 was greater than  362.58 ppm.  •

       The Agency does not anticipate that beneficial bisects will be at risk as a result of the
use of boric acid. Further, most of the boric acid use patterns for insect control are limited
to indoor use. Outdoor uses are considered to be infrequent.
                                           31

-------
                    d.     Effects on Hants Data

       Seed germination/seedling emergence and vegetative vigor are terrestrial phytotoxiciry
studies required for herbicides applied to terrestrial food, terrestrial nonfood, aquatic nonfood
(excluding residential) and forestry sites if any of the following conditions exist:

       •     The vapor pressure of the TGAI is equal to or greater than 1.0 x 10'smm Hg
             at 25°C and the TEP is not thoroughly incorporated immediately after
             application.

       •     The TEP (excluding granular formulations) is applied by forced air, air blast,
             or through sprinkler irrigation.

       •     Endangered or threatened plant species are associated with the site of
             application (Le., "rights-of-way").

       •     There are field  incidents of plant phytotoxicity to commercially important
             plants. The potential phytotoxicity hazard to commercially important plants
             (e.g. citrus) has also been noted in the public literature.

       Because boric acid and its sodium salts meet all the above conditions, the Agency is
requiring these terrestrial phytotoxicity studies.

       In addition, aquatic plant testing is required for any herbicide applied to terrestrial
nonfood (rights-of-way and ditchbanks), aquatic food,  aquatic nonfood (excluding residential)
and forestry sites.  Boric acid and its sodium salts are  used in some of these sites .
Therefore, to meet this requirement the following species are to be tested:   Selenastrum
capricomutum. Lemna  gibba. Skeletonema costatum. Anabaena flos-aquae. and freshwater
diatom.

       However, these data requirements are not considered to be part of the target data
base, and therefore, they do not affect the reregistration eligibility of boric acid and its
sodium salts.

                     e.    Endangered Species Concern

       The literature on boric acid indicates that the noncrop herbicidal use has the potential
to harm endangered and threatened plant species.  The Agency is requiring data on the
phytotoxicity of the active ingredient on non-target plants to help determine whether the
noncrop herbicidal use of boric acid and its sodium salts may affect listed  endangered or
threatened plants.  Should the data indicate that their use may affect listed endangered or
threatened species of plants, the Agency will consult with the U.S. Fish and Wildlife
 Service.
                                            32

-------
       At the present time, the Agency is working with the U.S. Fish and Wildlife Service
and other federal and state agencies to develop a program to avoid jeopardizing the continued
existence of listed species by the use of pesticides. When the Endangered Species Protection
Program is implemented and subsequent guidance is given, endangered species labeling
amendments may be required on affected end-use products.   Labeling statements for end-use
products will likely refer users to county specific bulletins specifying detailed limitations on
use to protect endangered species.
IV.    RISK MANAGEMENT AND REREGISTRATION DECISION

       A.    Determination of Eligibility

       Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission of
relevant data concerning an active ingredient, whether products containing the active
ingredients are eligible for reregistration. The Agency in the Boric Acid and Boron
containing Salts Registration Standard previously identified and required the submission of
the generic (i.e., active ingredient specific) data required to support reregistration of products
containing boric acid and its sodium salts as active ingredients.  The Agency has completed
its review of these generic data, and has determined that the data are sufficient to support
reregistration of all products containing boric acid and its sodium salts (products containing
boric acid, sodium tetraborate decahydrate, sodium tetraborate pentahydrate, sodium
tetraborate (anhydrous borax), disodium octaborate decahydrate, disodium octaborate
(anhydrous), and sodium inelaborate).  Appendix B identifies the generic data requirements
that the Agency reviewed as part of its determination of reregistration for boric acid and its
sodium salts, and lists the submitted studies that the Agency found acceptable.

       The data identified in Appendix B were sufficient for the Agency to assess the
registered uses of boric acid and its sodium salts and to determine that boric acid and its
sodium salts products can be used without resulting in unreasonable adverse effects to man
and the environment.  The Agency therefore finds that all products containing boric acid and
its sodium salts as the active ingredients are eligible for reregistration.  The reregistration of
particular products is addressed in Section V of this document.

       The Agency made its reregistration eligibility determination based upon the target data
base required for reregistration, the current guidelines for conducting acceptable studies to
generate such data and the data  identified in Appendix B. Although the Agency has found
mat all uses of boric  acid and its sodium salts are eligible for reregistration, it should be
understood that the Agency may take appropriate regulatory action, and/or require the
submission of additional data to support the registration of products containing boric acid and
its sodium salts, if new information comes to the Agency'"s attention or if the data
requirements for registration (or the guidelines for generating such data) change.
                                          33

-------
              1.     Eligibility Decision

       Based on the reviews of the generic data for the active ingredients of boric acid and
its sodium salts, the Agency has sufficient information on the health effects of boric acid and
its sodium salts and their potential for causing adverse effects in fish and wildlife and the
environment.  Therefore, the Agency concludes that products containing boric acid and its
sodium salts for all uses are eligible for reregistration.

       The Agency has determined that boric acid and its sodium salts, labeled and used as
specified in this RED document, will not pose unreasonable risks or adverse effects to
humans or the environment.

       However, before reregistering these products, the Agency is requiring the submittal or
citation of product specific data (chemistry, acute toxicity, and efficacy (if needed), a revised
Confidential Statement of Formula (CSF), and revised labeling within eight months of the
issuance of this document.  Refer to Section VI of this document.  After these data and
labeling have  been found acceptable, the Agency will reregister a product if it meets the
requirements in Section 3(c)(5) of FIFRA.  Those products containing more than one active
ingredient will be eligible for reregistration only when the other active ingredients are
eligible for reregistration.

       Unlike products covered by the Boric Acid and Boron Containing Salts Registration
Standard, the  Agency has already reregistered all products covered by the General
Registration Standard for Boric Acid.  For these products, the only additional requirement in
this RFJ> will be the submission of a current label and CSF to insure that each product is
still in compliance with its special certification form submitted earlier.

              2.    Eligible and Ineligible Uses

       The Agency has determined that all uses of boric acid and its sodium salts are eligible
for reregistration.

       B.    Regulatory Position

       The following is a summary of the regulatory positions and  rationales for boric acid
and its sodium salts.  Where labeling revisions are imposed, specific language is set forth in
Section V of this document.

              1.     Tolerance Reassessment

       Boron occurs naturally in water, fruits, vegetables, and forage crops, and is an
essential  nutrient for plants.  In pears and strawberries the levels may reach 160 ppm, and in
red cabbage occasionally as high as 200 to 300 ppm. The increment of added boron residues
resulting  from pesticide use of boric acid and the boron-containing  salts is insignificant

                                            34

-------
compared to levels of naturally occurring boron in citrus and cottonseed. For example,
lemons average 1 ppm incremental boron due to treatment, compared with the 2.5 ppm
boron which is endogenous.

      Existing tolerances of boron resulting from the use of boric acid and certain
derivatives were established under 40 CFR 180.271, for cottonseed (30 ppm) and citrus fruits
(8 ppm, post-harvest).  Codex maximum residue limits (MRL's) have not been recommended
for boron, and tolerances have not  been established in Canada or Mexico for residues of
boron in any food or feed commodity.  The Boric Acid and Boron Containing Salts
Registration Standard indicated that the Agency would consider revoking the existing
tolerances and replacing them with an exemption as well as establish food additive
regulations to  cover the food/feed handling uses at such time as the required toxicology
studies were submitted and reviewed.

      No lexicological  concerns have been raised by the review of the toxicology data.
Based on this and the fact that the increment of added boron residues resulting from pesticide
use of boric acid and boron containing salts is insignificant compared to levels of naturally
occurring boron, the Agency has determined that boric acid and its sodium salts should be
exempted from the requirements of a tolerance on all raw agricultural commodities under
Section 408.  This exemption in 40 CFR 180 will also cover the fire ant control use of boric
acid in agricultural areas.  In addition, because boric acid salts are registered for crack and
crevice use in  food and feed handling establishments, the Agency will propose food and feed
additive regulations for boric acid and its salts at food/feed handling sites under Section 409
of FFDCA. With these actions, there are no residue chemistry data requirements remaining
for boric acid  and its sodium salts.

      On August 20, 1993, the Agency established an exemption from the requirement of a
tolerance for residues of boric acid and its salts on all raw agricultural commodities and
removed the following established tolerances in cotton seed and citris fruits under 40 CFR
180.271.

      The exemption has been established under 40 CFR 180.1121, and reads as follows:

       "An exemption from the requirement of a tolerance for residues of boric acid, sodium
      tetraborate decahydrate (borax decahydrate), sodium tetraborate (anhydrous borax),
      disodium octaborate tetrahydrate, sodium metaborate, and boric oxide is established in
      raw agricultural commodities when used as insecticides, herbicides or fungicides pre-
      01 postharvest in accordance with good  agricultural practices."

      The Agency will issue a federal register notice to amend the exemption from
tolerances to include the two derivatives, sodium tetraborate pentahydrate (borax
pentahydrate) and disodium octaborate (anhydrous), omitted from the original notice.
                                          35

-------
       The Agency will propose establishing the following food and feed additive regulations
under 40 CFR 185 and 186 respectively:

o  CFR 40 185:

       "A food additive regulation is established permitting the use of boric acid, sodium
tetraborate decahydrate (borax decahydiate), sodium tetraborate pentahydrate (borax
pentahydrate), sodium tetraboiate  (anhydrous borax), disodium octaborate tetrahydrate,
disodium octaborate (anhydrous),  sodium inelaborate, and boric oxide in food handling
establishments in accordance with the following prescribed condition:

       Application shall be limited solely to careful treatment in food handling establishments
       where food and food products are held, processed, prepared or served such that
       contamination of food or food contact surfaces shall be avoided."

o  CFR 40 186:

       "A feed additive regulation is established permitting the use of boric acid, sodium
tetraboiate decahydrate (borax decahydrate), sodium tetraborate pentahydrate (borax
pentahydrate), sodium tetraborate (anhydrous borax), disodium octaborate tetrahydrate,
disodium octaborate (anhydrous),  sodium inelaborate, and boric oxide in animal feed
handling establishments in accordance with the following prescribed condition:

       Application shall be limited solely to careful treatment in animal feed handling
       establishments where feed and feed products are held, processed, prepared or sold
       such that contamination of feed or feed contact surfaces shall be avoided."
 V.    ACTIONS REQUIRED BY REGISTRANTS

       This section specifies the data requirements and responses necessary for the
 reregistration of both manufacturing-use and end-use products of boric acid and its sodium
 salts.

       A.     Manufacturing-Use Products

              1.     Generic Data Requirements

       The generic data base supporting the reregistration of boric acid and its sodium salts,
 for all eligible uses has been reviewed and determined to be substantially complete.
 However,  some additional product chemistry information must be submitted and there exists
 a data gap for phytotoxicity studies.  All of the product chemistry data for boric acid and its
 sodium salts were originally required in the Boric Acid and Boron Containing Salts
                                           36

-------
Registration Standard and are therefore not included in a generic Data Call-In issued with
this RED document.  Nevertheless, the heibicidal uses justify the requirement of
phytotoxicity studies in order to further assess the potential risks to non-target plants and to
endangered plant species.  Additionally, public literature studies cite the possible
phytotoxicity hazard of boron to commercially important plants.  The following phytotoxicity
studies are required:
              123-l(a)      Seed germination/seedling emergence
              123-l(b)      Vegetative vigor
              123-2        Aquatic plant growth with Lemna gibba, Skeletonema costatum
                           Anabaena flosaquae, and a freshwater diatom (Navicula).
             2.     Labeling

       All manufacturing-use products or end-use products that may be contained hi an
effluent discharged to the waters of the United States or municipal sewer systems must bear
the following revised effluent discharge labeling statement:

       "Do not discharge effluent containing this product into lakes, streams, ponds,
       estuaries, oceans or other waters unless in accordance with the requirements of a
       National Pollutant Discharge Elimination System (NPDES) permit and the permitting
       authority has been notified in writing prior to discharge.  Do not discharge effluent
       containing this product to sewer systems without previously notifying the local sewage
       treatment plant authority.  For guidance contact your State Water Board or Regional
       Office of the EPA.

       All affected products distributed or sold by registrants and distributors (supplemental
registrants) must bear the above labeling by October 1, 1995.   All products distributed or
sold by persons other than registrants or supplemental registrants after October 1, 1997 must
bear the correct labeling.  Refer to PR Notice 91-8: Revised Policy to  Provide Applicants
Other Than Basic Manufacturers An Opportunity To Submit Generic Data and Receive Data
Compensation For It, PR Notice 93-10: Effluent Discharge Labeling Statements and, 40 CFR
152.46(a)(l) for further information.  Additionally,  all products must be in  compliance with
current labelling regulations as  spectified in
40 CFR 156.10.
                                           37

-------
       B.    End-Use Products

             1.     Product-Specific Data Requirements

       Section 4(g)(2)B) of FIFRA calls for the Agency to obtain any needed
product-specific data regarding the pesticide after a determination of eligibility has been
made.  The product specific data requirements are listed in Attachment 3 of Appendix (E), in
the Combined Generic and Product Specific Data Call-in Notice.

                    a.    Products Under the General Registration Standard for Boric
                          Acid

       For products that meet the criteria of the Guidance for the General Registration
Standard and were registered and/or reregistered under the Agency's  General Reregistration
Standard:

o      The registrant relied on available data to support registration or reregistration,
       products are 100% boric acid or 99% boric acid with one of the following inert
       ingredients: 1 % tricalcium phosphate, 1 % magnesium stearate, 1 % calcium silicate,
       1 % diatomaceous earth;
o      Certified limit for the active ingredient for all formulations containing one of the inert
       ingredients specified above is 99.0 to 99.5%; with a certified  limit for the inert being
       0.5 to 1.0%;
o      Products are in Toxicity Categories in and IV;
o      Products are used only for domestic and nondomestic indoor use for cockroach, ant,
       and silverfish control;
o      Registrants and applicants purchase their technical from a registered  source, and have
       adopted one of the standard labels);

the Agency is requiring submission of a current label and a CSF  within 8 months of
receipt of this document.

                    b.     Products Under the Boric Acid and Boron Containing Salts
                           Registration Standard

       For products  under the Boric Acid and Boron Containing Salts Registration Standard,
the Agency is requiring submission of documentation of their previous successful
completion of the product specific data requirements within 90 days of  the receipt of this
document. If the Agency verifies this documentation, it will only require submission of
a  revised label and  revised CSF within 8 months of receipt of this document. After the
Agency  reviews this material, the Agency will determine whether to  reregister each product
based  on whether or not it meets the requirements in section 3(c)(5)  of the Federal
Insecticide, Fungicide and Rodenticide Act.  Those products which contain other active
                                           38

-------
ingredients will be eligible for reiegistration only when the other active ingredients are
determined to be eligible for reiegistration.

       Registrants must review previous data submissions to ensure that they meet current
EPA acceptance criteria (Appendix E, Attachment 5) and if not, commit to conduct new
studies. If a registrant believes that previously submitted data meet current testing standards,
then study MRED numbers should be cited according to the  instructions in the Requirement
Status and Registrants Response Form provided for each product.  For batching options to
satisfy data requirements refer to Appendix E, Attachment 4,

                    c.     Products not included in either Boric Acid Standards

       For products not included in either of the two previously issued standards (i.e.,
sodium metaborate), the registrants must either submit product specific data or cite
previously submitted data to support their registrations and submit revised labeling,
CSFs, application for reregistration, and a certification with respect to citation of data
within 8 months of receipt of this document before the products will be considered for
reregistration. After the Agency reviews these data and the revised labels, the Agency will
determine whether to reregister each product based on whether or not it meets the
requirements in section 3(c)(5) of the Federal Insecticide, Fungicide and Rodenticide Act.
Those products which contain other active ingredients will be eligible for reregistration only
when the other active ingredients are determined to be eligible for reregistration.  Refer to
Appendix E, Attachment 4 on batching for options to satisfy data requirements.

              2.     Labeling

       The labels and labeling of all products must comply  with EPA's current regulations
and requirements as specified.  Please follow the instructions in the Summary of Instructions
for Responding to the Reregistration Eligibility  Decision Document with respect to labels and
labeling.

       The Agency has determined that the current label precautions are still applicable and
are required for product reregistration.

                    a.     Compliance with the Worker Protection Standard

       Any product whose labeling reasonably permits use in the production of an
agricultural plant on any agricultural establishment (farm, forest, nursery, or greenhouse)
must comply with the labeling requirements of PR Notice 93-7, "Labeling Revisions
Required by the Worker Protection Standard (WPS), and PR Notice 93-11, "Supplemental
Guidance for PR Notice 93-7," which reflect the requirements of EPA's labeling regulations
for worker protection statements (40 CFR part  156, subpart K).  These labeling revisions are
necessary to implement the Worker Protection Standard for Agricultural Pesticides (40 CFR
Part 170) and must be completed in accordance with, and within the deadlines specified in,


                                           39

-------
PR Notices 93-7 and 93-11.  Unless otherwise specifically directed in this RED or by other
EPA guidance, all statements required by PR Notices 93-7 and 93-11 are to be on the
product labeling exactly as instructed in those notices.

       o            After April 21, 1994, except as otherwise provided in PR Notices 93-7
             and 93-11,  all products within the scope of those notices must bear WPS PR-
             Notice-coraplying labeling when they are distributed or sold by  the primary
             registrant or any supplemental^ registered distributor.

       o            After October 23, 1995, except as otherwise provided in PR Notices
             93-7 and 93-11, all products within the scope of those notices must bear WPS
             PR-Notice-complying labeling when they are distributed or sold by any person.

       Personal Protective Equipment Requirements

             •   Uses On Products NOT Primarily Intended for Home Use: The personal
             protective equipment (PPE) requirement for pesticide handlers on all end-use
             products, except those intended primarily for home use (see tests in PR Notice
             93-7 and 93-11), is:

                    "Applicators and  other handlers must wear:
                          —Long-sleeved shirt and long pants
                          —Chemical-resistant or waterproof gloves (see instructions
                                 * below)
                          -Shoes plus socks

                          (*) The glove statement is the  statement established through the
                          instructions in Supplement Three of PR Notice 93-7,

                    End-use products that contain boric acid (and its related  compounds)
             must compare the personal protective equipment requirements set forth in this
             section to the personal protective equipment requirements, if any, on their
             current labeling and retain the more protective required PPE. For guidance in
             choosing which requirement is more protective, see Supplement Three of PR
             Notice 93-7,  If the existing labeling requires a respirator, use the guidance in
             Supplement Three of PR Notice 93-7 to determine the appropriate respirator
             statement.

             •   Uses of Products Primarily Intended for Home Use: For products
             primarily intended for home use (see tests in PR Notice 93-7 and 93-11), do
             not add any additional personal protective equipment requirements (PPE) for
             such products, however, any PPE requirements on the current product labeling
             must be retained.
                                          40

-------
       Entry Restrictions

              • Products NOT Primarily Intended for Home Use

             Uses Within the Scope of the WPS:  A 12-hour restricted entry interval
              (RET) is required for all uses within the scope of the WPS (see PR Notice 93-
             7) on all end-use products, except those intended primarily for home use (see
             tests in PR Notice 93-7 and 93-11). This REE should be inserted into the
             standardized REE statement required by PR Notice 93-7. The personal
             protective equipment for early entry should be the PPE required for applicators
             of boric acid (and its related compounds) except that the requirement for an
             apron or respirator is waived.  This PPE should be inserted into the
             standardized early entry PPE statement required by PR Notice 93-7."

                    Sole-active-ingredient end-use products that contain boric acid (and its
                    related compounds) must be revised to adopt the entry restrictions set
                    forth in this section.  Any conflicting entry restrictions on their current
                    labeling must be removed.

                    Multiple-active-ingredient end-use products that contain boric acid
                    (and its related compounds) must compare the entry restrictions set
                    forth in this section to the entry restrictions on their current labeling
                    and retain the more protective entry restrictions. A specific time-period
                    in hours or days is considered more protective than "sprays have dried"
                    or "dusts have settled."

             Uses Not Within the Scope of the WPS: Do not add any additional entry
             restrictions for uses not within the scope of the WPS, however, any entry
             restrictions on the current product labeling for those uses must be retained.

             Products Primarily Intended for Home Use: For products  primarily
             intended for home use (see tests in PR Notice 93-7 and 93-11), do not add any
             additional entry restrictions for such products, however, any entry restrictions
             on the current product labeling must be retained.

                    b.     Compliance with the Existing Stocks Provision

       Registrants may generally distribute and sell products bearing old labels/labeling for
26 months from the date of the issuance of this Reregistration Eligibility Decision Document
(RED). Persons other than registrants may generally distribute or sell such products for  50
months from the date of the issuance of this RED. However, existing stocks time frames
will be established case-by-case, depending on the number of products involved, the number
of label changes, and other factors. Refer to "Existing Stocks of Pesticide Products;
Statement of Policy", Federal Register. Volume 56,  No.  123, June 26, 1991.

                                          41

-------
                    c.     Products Under the General Boric Acid Standard

      Labels must comply with the format labels issued with the General Boric Acid
Standard.  Submit five copies of current labeling.

                    d.     Products Not Under General Boric Acid Standard

      Labels must comply with 40 CFR 156.10 and the requirements listed below, if they
are appropriate.

      o EnviTpnmenfal Hazard Section -

             1) Terrestrial Food & Feed and Non-Crop

             Do not apply directly to water, or to areas where surface water is present or to
             intertidal areas below the mean high-water mark. Do not contaminate water
             when disposing of equipment washwaters or rinsate.

             2) Indoor Uses with Effluents

             Do not discharge effluent containing this product into lakes, streams, ponds,
             estuaries, oceans or other waters unless in accordance with the requirements of
             a National Pollutant Discharge Elimination System (NPDES) permit and the
             permitting authority has been notified in writing prior to discharge.  Do not
             discharge effluent containing this product to sewer systems without previously
             notifying the local sewage treatment plant authority.  For guidance contact
             your State Water Board or Regional Office of the EPA.

      o     Under "Directions for Use'L-

             Labels for uses associated with boric acid on carpets and floors to combat
             fleas, cockroches, ants, and silverfish:

             Use Restrictions -

                    Children and pets should not be in treatment area until after application
                    is completed. Do not treat pets with this product.  Avoid
                    contamination of feed and foodstuff. Avoid contamination of
                    ornamental plants.
                                          42

-------
Carpets -
       Apply to dry surfaces only.  Apply directly on carpets where pets
       frequently traffic or sleep.  Work powder deeply into fibers and mat
       with a broom or nig rake.  Any powder visible after application must
       be brushed into carpet fibers or removed.
Upholstery -
       Remove loose cushions.  Apply along creases and into comers and
       furniture wells.  Do not apply product to exposed fabric.  Any product
       visible after application must be removed.
                             43

-------

-------
VI.   APPENDICES

-------

-------
       APPENDIX A

  Table of Use Patterns
Subject to Reregistration

-------

-------
APPENDIX A - Use patterns subject to reregistration for: CASE <0024>, 
-------
Application Type, Application lining, Application Equipment
USE SITE/USE GROUP
BORIC ACID (CHEMICAL 011001)
Bait station. When needed. Unspecified
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NOH-FOOD
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
SEWAGE SYSTEMS USE GROUP: AQUATIC NOH-FOOO INDUSTRIAL
SPECIALIZED ANIMALS USE GROUP: INDOOR NOM-FOOD
Bait station, When needed. Unspecified
COMMERCIAL TRANSPORT AT ION FACILITIES- -FEED & FOOD EMPTY USE GROUP: INDOOR FOOD
EATING ESTABLISHMENTS USE GROUP: INDOOR FOOD
FOOD PROCESSING PLANT PREMISES (WON -FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD/GROCERY/MARKET I NG/STORAGE/D I STR I flJTI OH FACILITY PREMISES USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FACILITIES--NON-FEED/NON-FOOD USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
SEWAGE SYSTEMS USE GROUP; AQUATIC NON-FOOD INDUSTRIAL
SPECIALIZED ANIMALS USE GROUP: INDOOR NON-FOOD
Bait station, When needed. Package applicator
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
HOUSEHOLD/DOMESTIC DWELLING OUTDOOR PREMISES USE GROUP: OUTDOOR RESIDENTIAL
Bait station, When needed. Unspecified
HOUSEHOLD /DOMESTIC DWELLING OUTDOOR PREMISES USE GROUP: OUTDOOR RESIDENTIAL
ORNAMENTAL LAWNS & TURF USE- GROUP: TERRESTRIAL NON-FOOD + OUTDOOR RESIDENTIAL
Bait station, When needed, Unspecified
ORNAMENTAL LAWNS & TURF USE GROUP: TERRESTRIAL NON-FOOD + OUTDOOR RESIDENTIAL
Broadcast, When needed, Fixed-wing aircraft or Spreader
AGRICULTURAL CROPS/SOILS (UNSPECIFIED) USE GROUP: TERRESTRIAL FOOD & FEED USES
ORCHARDS (UNSPECIFIED) USE GROUP: TERRESTRIAL FOOD fc FEED USES
Broadcast, When needed, Fixed-Ming aircraft or Spreader
AGRICULTURAL UNCULTIVATED AREAS USE GROUP: TERRESTRIAL NON-FOOD CROP
GOLF COURSE TURF USE GROUP TERRESTRIAL NON-FOOD CROP
NONAGRI CULTURAL R1GHTS-OF-WAY/ FENCE ROWS/ HEDGEROWS USE GROUP: TERRESTRIAL NON-FOOD CROP
NONAGRI CULTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NOM-FOOD CROP
ORNAMENTAL LAWNS t, TURF USE GROUP: TERRESTRIAL MON-FOOD + OUTDOOR RESIDENTIAL
RECREATIONAL AREAS USE GROUP: TERRESTRIAL NON- FOOD CROP
Contact treatment or Surface treatment, When needed, Aerosol can
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
Form
B/S
B/S
B/L
B/S
B/S
G
G
PRL
Maximum
Application
Rate
(ai)
Not
quantified
Mot
quantified
Not
quantified
.004 bait
stations/
ft.
4.5 tb/A
0.54 Ib/A
0.54 Lb/A
1 sec/spot
Kin.
Interval
Between
Apps. 3
Max. Rate
(Days)
90
As needed
As needed
30
Not
specified
5
5
Not
spec i f i ed
Restricted
Entry
Interval
(Hours)





12


Use Limitations









-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
BORIC ACID (CHEMICAL 011001)
Contact treatment or Surface treatment, When needed, Aerosol can
COMMERCIAL TRANSPORTATION FACILITIES-FEED £ FOOD EMPTY USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
COMMERCIAL IRAN SPORT AT I OH FACILITIES--NON-FEED/HON-FOOD USE GROUP: INDOOR NON-FOOD
COKMERCIAL/INSTITUTIONAL/IMDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS MOM- FOOD AREAS (NON-FOOD CONTACT) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/ VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLDyOOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Crack & crevice treatment, When needed, Aerosol can
EATING ESTABLISHMENTS FOOD HANDLING AREAS (FOOD CONTACT] USE GROUP: INDOOR FOOD
EATING ESTABLISHMENTS FOOD SERVING AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD PROCESSING PLANT PREMISES (NON-FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD/GROCERY/MARKETIHG/STORAGE/DISTRIBUTION FACILITY PREMISES USE GROUP: INDOOR FOOD
Crack & crevice treatment or Spot treatment. When needed, Aerosol can
COMMERCIAL TRANSPORTATION FACILITIES-FEED & FOOD EMPTY USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
COMMERCIAL TRANSPORTATION FACI LI TIES- -WON- FEED/WON- FOOD USE GROUP: INDOOR NON-
FOODCOMNERCIAL/INSTITUTIONAI/INOUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-
FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUNAN/VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DWELLINGS USE GROUP: IHDOOR RESIDENTIAL
Crack & crevice treatment, Uhen needed. Unspecified
COMMERCIAL TRANSPORTATION FACILITIES-FEED & FOOD EKPTY USE GROUP: INDOOR FOOD
EATING ESTABLISHMENTS FOOD HAHDUHG AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
EATING ESTABLISHMENTS FOOD SERVING AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD PROCESSING PLANT PREMISES (NON-FOOD COUTACT) USE GROUP: INDOOR FOOD
FOOD/GROCERY/MARKETIHG/STORAGE/DISTRIBUTIOH FACILITY PREMISES USE GROUP: INDOOR FOOD
HOUSE HOLD /DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FACILITIES-WON- FEED/NON-FOOD USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/INOUSTRIAL PREMISES/EOU1PMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS NON-FOOD AREAS (NON-FOOD CONTACT) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/ VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
PET LIVING/SLEEPING QUARTERS USE GROUP: IHDOOR RESIDENTIAL
SPECIALIZED ANIMALS USE GROUP: INDOOR NON-FOOD
Crack & crevice treatment or Spot treatment. When needed, Squeeze applicator
HOUSEHOLD/DOMESTIC DUELLIMGS USE CROUP: IMDOOR RESIDENTIAL
Form
PRL or
PRO
PRL
PRL or
PRO
B/S
D
Max i nun
Application
Rate
(ai)
Not
quantified
.2 sec/
linear ft.
1 sec/
linear ft.
18. B units/
1000 sq.ft.
At lb/ 1000
sq. ft.
Hin.
Interval
Between
Apps. a
Max. Rate
(Days)
As needed
Not
specified
As needed
H
As needed
Restricted
Entry
Interval
(Hours)





Use Limitations






-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
BORIC ACID (CHEMICAL 011001)
Crack & crevice treatment, Uhen needed. Knife or Spatula or Unspecified
COMMERCIAL TRANSPORTATION FACILITIES-FEED & FOOD EMPTY USE GROUP: INDOOR FOOD
EATING ESTABLISHMENTS FOOD HANDLING AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
EATING ESTABLISHMENTS FOOD SERVING AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD PROCESSING PLANT PREMISES (NON-FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD/GROCERY/MARKETING/STORAGE/DISTRIBUTION FACILITY PREMISES USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FACILIT1ES--MON-FEED/NQN-FOOD USE GROUP: INDOOR NON-FOOD
COMHERCIAL/INSTJTUTIONAL/IMDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS NON-FOOD AREAS (NON-FOOD CONTACT) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/ VETERINARY) USE GROUP: INOOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
SPECIALIZED ANIMALS USE GROUP: INOOOR NON-fOOO
Crack & crevice or Spot treatment. When needed, Bulbous duster or By hand or Knife or Spatula
or Squeeze applicator or Spoon or Unspecified
COMMERCIAL TRANSPORTATION FACILITIES-FEED £ FOOD EMPTY USE GROUP: INDOOR FOOD
EATING ESTABLISHMENTS USE GROUP: ENDOOft FOOD
EATING ESTABLISHMENTS FOOD HANDLING AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
EATING ESTABLISHMENTS FOOD SERVING AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD PROCESSING PLANT NON-FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
FOOD PROCESSING PLANT PREMISES (NON-FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD/GROCERY/MARKET I NG/STORAGE/D I STR I BUT ION FACILITY PREMISES USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
POULTRY PROCESSING PLANT PREMISES (NON-FOOD CONTACT) USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FACILITIES--NOH-FEED/NOH-FOOO USE GROUP: INDOOR NON-FOOD
COMKERC1AL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/ECU I PMENT (OUTDOOR) USE GROUP: TERRESTRIAL
NON-FOOD
EATING ESTABLISHMENTS NON-FOOD AREAS (NON-FOOD CONTACT) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUNAN/ VETERINARY 3 USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
HOUSEHOLD/DOMESTIC DUELLING OUTDOOR PREMISES USE GROUP: OUTDOOR RESIDENTIAL
NONAGRI CULTURAL UNCULTIVATED AREAS/SOILS TERRESTRIAL NON-FOOD CROP
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
RECREATIONAL AREAS USE GROUP: TERRESTRIAL NON-FOOD CROP
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
SPECIALIZED ANIMALS USE GROUP: INDOOR NON-FOOD
Crack & crevice treatment or Spot treatment, Uhen needed, Spoon
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
Dip, When needed, Unspecified
UOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS INDOOR USE GROUP: IMDOOR RESIDENTIAL
Form
B/S
HTU or
D or
UP/D
or B/S
D
RTU
Maximum
Application
Rate

Not
quantified
Not
quantified
.5 tsp/gat
Not
quantified
Min.
Interval
Between
Apps. &
Max. Rate
(Days)
365
As needed
or Nat
specified
As needed
Not
specified
Restricted
Entry
Interval
(Hours)




Use Limitations





-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
BORIC ACID (CHEMICAL 011001)
Dust, Uhen needed. Brush
HOUSEHOLD/DOMESTIC DUELLINGS CONTENTS USE GROUP INDOOR RESIDENTIAL
PET LIVING/SLEEPING OUARTERS USE GROUP: INDOOR RESIDENTIAL
Oust, Uhen needed. Unspecified
HOUSEHOLD/DOMESTIC DUELLINGS CONTEUTS USE GROUP INDOOR RESIDENTIAL
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
Enclosed premise treatment, Uhen needed, Pressure sprayer or Sprayer or Spreader
POULTRY (EGG/HEAT) USE GROUP: INDOOR FOOD
Enclosed premise treatment, Uhen needed, Spreader
POULTRY (EGG/NEAT) USE GROUP: INDOOR FOOD
Enclosed premise treatment, When needed, Shaker can
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
Indoor general surface treatment, Uhen needed, Shaker cart or Spoon or Unspecified
FOOD/GROCERY/KARKET1NG/STORAGE/DISTRIBUTION FACILITY PREMISES USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL STORAGES/WAREHOUSES PREMISES (INDOOR) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FACILIT1ES--HON-FEED/MON-FOOD USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/ INDUSTRIAL PREMISES/EOJIPMENT 
3.25 lb/
1000 sq. ft.
Not
quantified
19.96 lb/
1000 sq.ft.
6 lb/1000
sq.ft.
Not
quantified
Not
quantified
.99 lb/1000
sq. ft.
10 see/spot
19.96 lb/
1000 sq. ft.
6 lb/1000
sq. ft.
Hin.
Interval
Between
Apps. a
Max. Rate
(Days)
Not
specified
Not
specified
As needed
or Not
specified
As needed
Not
specified
As needed
or Hot
specified
As needed
Not
specified
As needed
As needed
Restricted
Entry
Interval
(Hours)










Use Limitations











-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
BORIC ACID (CHEMICAL 011001)
Mop, When needed. Mop
FOOO/GROCERY/MARKETING/STORAGE/DISTRIBUTIOK FACILITY PREHISES USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOT
AMIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL STORAGES/WAREHOUSES PREHISES (INDOOR) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FACILITIES--NON-FEED/HON-FOCO USE GROUP: INDOOR MOM-FOOD
COMMERCIAL/! NSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: IMDOOR NOW- FOOD
EATING ESTABLISHMENTS NON-FOOD AREAS (NON-FOOD CONTACT) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/VETERINARY) USE GROUP: IHDOOR MEDICAL
HOUSEHOLD/DOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
HOUSE HOLD/DOMESTIC DWELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
SPECIALIZED ANIMALS USE GROUP: IMDOOR NON-FOOD
Nonsoil contact nonfunigation, Uhen needed, Dip tank or Sprayer
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL MOM-FOOD
Perimeter treatment, When needed. Unspecified
COMMERCIAL/INSTITUTIONAL/ INDUSTRIAL PREMISES/EQUIPMENT (OUTDOOR) USE GROUP: TERRESTRIAL
NON-FOOD
Perimeter treatment, When needed, Unspecified
HOUSEHOLD /DOMESTIC DWELLING OUTDOOR PREMISES USE GROUP: OUTDOOR RESIDENTIAL
Preservative treatment. When needed, Unspecified
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS INDOOR USE GROUP: INDOOR RESIDENTIAL
Sewer treatment. When needed, Airblower
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Sewer treatment. When needed, Ouster
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Sewer treatment. When needed, Shake r can or Spoon
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Spot treatment, When reeded, Spoon
BARNS/BARNYARDS/AUCTION BARNS USE GROUP: INDOOR FOOD
Spot treatment, Uhen needed, Spoon or Unspecified
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
Spot treatment, When needed, Unspecified
MEAT PROCESSING PLANT PREMISES (NON-FOOD CONTACT) USE GROUP: INDOOR FOOD
Spot treatment, Uhen needed, Brush
HOUSEHOLD/DOMESTIC DWELLINGS CONTENTS USE GROUP: INDOOR RESIDENTIAL
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
Spot treatment. When needed, Duster
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Form
WP/D
RTU
B/S
B/S
RTU
D or
UP/D
WP/D
UP/0
D
D
D
WP/D
WP/D
Maximum
Application
Rate

-------
Application Type, Application Timing, Application Equipment
USE SITE/USE CROUP



BORIC ACID (CHEMICAL 011001)
Spot treatment, Uhen needed. Power duster
SEWAGE SYSTEMS USE GROUP: AQUATIC NOM-FOOD INDUSTRIAL
Spot treatment, Uhen needed. Package applicator
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
HOUSEHOLD/DOMESTIC DUELLING OUTDOOR PREMISES USE GROUP: OUTDOOR RESIDENTIAL
Spot treatment, Uhen needed. Powder duster
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS NOH-FOOO AREAS (NON-FOOD CONTACT) USE GROUP: IMDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: EMDOOR RESIDENTIAL
SPECIALIZED AH 1 HALS USE GROUP: INDOOR NON-FOOD
Spot treatment, Uhen needed. Unspecified
HOUSEHOLD/DOMESTIC DUELLINGS CONTENTS USE GROUP: INDOOR RESIDENTIAL
Spot treatment, Uhen needed, Unspecified
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
Spot treatment, Uhen needed, Knife or Spatula
SEWAGE SYSTEMS USE GROW: AQUATIC NON-FOOD INDUSTRIAL
Spot treatment, Ulien needed, Knife or Spatula or Spoon or Squeeze applicator or Unspecified
SEWAGE SYSTEMS USE GROUP: AQUATIC NOH-FOOO INDUSTRIAL

Spot treatment, Uhen needed, Unspecified
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Spray, When needed, Sprayer
WOOD PROTECTION TREATMEIIT TO BUILDINGS/PRODUCTS INDOOR USE GROUP: INDOOR RESIDENTIAL
Void treatment. When needed, Unspecified
EATING ESTABLISHMENTS USE GROUP: INDOOR FOOD + INDOOR NON-FOOD
FOOD PROCESSING PLANT PREMISES (NON-FOOD CONTACT) USE GROUP: INDOOR FOOD +• INDOOR NON-FOOD
COMMERCIAL/1MST1TUT10NAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/VETERINARY) JSE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
WOOD PROTECTION TREATMENT TO BUILD INGS/PRODUCTS INDOOR USE GROUP: INDOOR RESIDENTIAL
Void treatment, Uhen needed, Knife or Spatula or Unspecified
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR} USE GROUP: INDOOR NON-FOOD
HOUSEHOLD/DOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
Form




D

B/L


D






D

D

B/S

B/S or
D or
WP/D
B/S

RTU

IMPR






B/S


Maximum
Application
Rate


(ai)
1.9 lb/
manhole
Not
quantified

5 sec/spot






3.25 lb/
1000 sq.ft.
6.5 I b/ 1000
sq.ft.
Not
quantified
Hot
quantified

18.8 units/
1000 sq.ft.
NOt
quantified
0.33 lb/
sq.ft.





Not
quantified

Min.
Interval
Between
Apps. a
Max. Rate
(Days)
As needed

As needed


As needed






As needed

As needed

365

As needed


U

HOt
specified
As needed






365


Restricted
Entry
Interval


(Hours)



































Use Limitations








































-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP



DORIC ACID (CHEMICAL 011001)
Void treatment. When needed, Duster or Unspecified
FOOD/GROCERY/MARKETING/STORAGE/DISTRIBUTION FACILITY PREMISES USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR MON-FOOO
COMMERCIAL STORAGES/WAREHOUSES PREMISES (INDOOR) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FACI LIT IES--HON- FEED/NON-FOOD USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS NON-FOOD AREAS (NON-FOOD CONTACT) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
SPECIALIZED ANIMALS USE GROUP: INDOOR NON-FOOD
Void treatment. When needed, Unspecified
COMMERCIAL/INSTITUTIONAL/INOUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
Void treatment. When needed, Aerosol can
COMMERCIAL/INSTITUTIOHAL/INOUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
Void treatment, When needed, Power duster or Unspecified
COMMERCIAL/INSTITUT10NAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
Void treatment, When needed, Squeeze applicator
COMMERCIAL/ INSTITUTIONAL/ INDUSTRIAL PREKISES/EWJPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOUSEHOLD /DOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
Void treatment. When needed, Knife or Spatula or Squeeze applicator or Unspecified
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NOH-FOOD
HOUSEHOLD/DOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
Void treatment. When needed, Aerosol can
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Wood protection treatment by pressure, When needed, Pressure treating vessel
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Form





UP/D
or D










B/S


PRO or
PRL

D


D


B/S


PRO


SC/S

Maximum
Application
Rate


Cat)
Hot
quantified










18.6 unit/
1000 sq. ft.

1 sec/sq.ft.


3.96 lb/
1000 sq.ft.

1.96 lb/
1000 eq.ft.

Not
Quantified

.2 s«c/
sq.ft.

Not
quantified
Min.
Interval
Between
Apps. a
Max. Rate
(Days)
As needed











U


30


As needed


As needed


As needed


As needed


Not
specified
Restricted
Entry
Interval


(Hours)
































Use Limitations





































Abbreviations used
   Header:  max.  = maximum;  min. =  minimum; apps. = applications;
   Form:  B/L  = Bait/Liquid; B/S =  Bait/Solid; D = Dust;  G  =  Granular;  IMPR  =  impregnated material  ; P/T = Pelleted/Tableted; PRO = Pressurized Dust;  PRL = Pressurized
   Liquid;  RTU =  Liquid-Ready to Use; SC/S = Soluble Concentrate/Solid;  WP/D = Wettable Powder/Dust
   Rate;  ai = active ingredient;  sec = second(s); Ib ~  pound;  A  =  acre;  sq.ft.  =  square foot; Not quantified application rates include the following  terminology:
   small  amount,  complete coverage,  uniform coverage, apply event/,  think film,  thoroughly spray, spray surfaces until wet, course spray, course wetting spray,  spray
   liberally,  apply  liberally,  etc.
The maximum number of applications and  the maximum nunfcer of applications at the maximum rate is not specified and has not been included.

-------
APPENDIX A - Use patterns subject to reregistration for: CASE <0024>, 
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
SODIUM TETRABORATE DECAHYDRATE (CHEMICAL 011102)
Bait station. When needed, Unspecified
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR fOOO
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
Bait station. When needed, Unspecified
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
Beit station, Uhen needed, Unspecified
HOUSEHOLD/DOMESTIC DUELLING OUTDOOR PREMISES USE GROUP: OUTDOOR RESIDENTIAL
ORNAMENTAL LAUHS AND TURF USE GROUP: TERRESTRIAL WON- FOOO + OUTDOOR RESIDENTIAL
Broadcast, Uhen needed, By hand or Spreader
INDUSTRIAL AREAS (OUTDOOR) USE GROUP TERRESTRIAL NON-FOOD
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD
Crack & crevice treatment, When needed. Bulbous duster
EATING ESTABLISHMENTS FOOD HANDLING AREAS (FOOD CONTACT) /EAT ING ESTABLISHMENTS FOOD SERVING
AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD PROCESSING PLANT PREMISES (NONFOOD CONTACT) USE GROUP: INDOOR FOOO
FOOD /GROCERY/MARKET I NG/STOR AGE/0 1 SIR I BUT I ON FACILITY PREMISES USE GROUP: INDOOR FOOO
Dip, When needed. Dip tank;
UOOO PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: INDOOR RESIDENTIAL
Indoor general surface treatment, Uhen needed, Unspecified
COMMERCIAL TRANSPORTATION FACILITIES--FEED/FGCO EMPTY USE GROUP: INDOOR FOOD
FOOD /GROCERY /MARKET I NG/STOR AGE/DISTRIBUTION FACILITY PREMISES USE GROUP: INDOOR FOOD
FOOO PROCESSING PLANT NON-FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FACIL1TIES--NONFEED/NON-FOOD USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS NON-FOOD AREAS (NONFOOD CONTACT) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
SPECIALIZED ANIMALS USE GROUP: INDOOR NON-FOOD
Injection treatment, Uhen needed, Power duster
COMMERCIAL TRANSPORTATION FAC1LITIES--FEED/FOCD EMPTY USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR MON-FOOD
COMMERCIAL TRANSPORTATION FAC1LITIES--NONFEED/NON-FOOD USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/ VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS USE GROUP: INDOOR RESIDENTIAL
SPECIALIZED ANIMALS USE GROUP: INDOOR HON-FOOO
Form
B/S
B/L
B/S
SC/S
CR
SC/L
CR
CR
Maximum
Application
Rate
(ai)
Not
quantified
Not
quantified
1 bait
station/
10 ft.
149.5 lb/
1000 sq.ft.
Not
quant i f i ed
1 part to 1
part water
Not
quant i f i ed
Not
quant i f i ed
Hin.
Interval
Between
Apps. a
Max. Rate
(Days)
30
As needed
30
Hot
specified
Not
specified
Not
specified
As needed
Not
specified
Restricted
Entry
Interval
(Hours)








Use Limitations









-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
SODIUM TETRABORATE DECAUTORATE (CHEMICAL 011102)
Hop, When needed. Hop
COMMERCIAL TRANSPORTATION FACILITIES--FEED/FOOO EMPTY USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
ANIMAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NON-FOOD
COMMERCIAL TRANSPORTATION FAClLITIES-NONFEED/MON-fOOD USE GROUP: INDOOR NON-FOOD
COMMERCIAL/ INSTITUTIONAL/ INDUSTRIAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUH AH/VETERINARY) USE GROUP: IHDOOR MEDICAL
HOUSEHOLD/DOMESTIC DWELLINGS USE GROUP: INDOOR RESIDENTIAL
SPECIALIZED ANIMALS USE GROUP: IHDOOR NON-FOOD
HonsoH contact nor fumigation, When needed. Dip tank or Sprayer
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Nonsoil contact nor fumigation, When needed, Dip tank
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (UNSEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Nonsoil contact non-fumigation, When needed. Sprayer
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (UNSEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Sewer treatment. When needed. Air-pressurized duster
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Sewer treatment. When needed, Airblower
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
Soil contact nonfumigation. When needed, Brush or Caulk gun or Tronel or Wrap
WOOD PROTECTION TREATMENT TO AQUATIC STRUCT!) RES/ IT EMS USE GROUP: AQUATIC NON-FOOD OUTDOOR
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS INDOOR USE GROUP: INDOOR RESIDENTIAL
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS OUTDOOR USE GROUP: OUTDOOR RESIDENTIAL
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Spot treatment, When needed, Unspecified
EATING ESTABLISHMENTS FOOD SERVING AREAS (FOOD CONTACT) USE GROUP: INDOOR FOOD
Spot treatment, When needed. Unspecified
HOUSE HOLD /DOMESTIC DWELLINGS CONTENTS USE GROUP: INDOOR RESIDENTIAL
Spray, When needed, Sprayer
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD
Sprinkle, When needed. Shaker can
HOUSEHOLD/DOMESTIC DUELLINGS CONTENTS USE GROUP: INDOOR RESIDENTIAL
Stump treatment. When needed, Shaker can or Sprayer
FOREST TREE MANAGEMENT/FOREST PEST MANAGEMENT USE GROUP: FORESTRY
SITE NOT SPECIFIED
Form
CR
RTU
SC/S
SC/L
CR
CR
RTU
CR
CR
SC/S
CR
SC/S
or CR
Hex i mum
Application
Rate
(ai)
0.63 Ib/gal
Not
quant i f i ed
.2 Ib/gal
1 part to 1
part water
2,67 Ib/
1000 sq.ft.
3.95 Ib/
1000 sq.ft.
Not
quantified
Not
quantified
20 lb/1000
sq.ft.
34 Ib/ gal
2.5 IW1QOO
sq.ft.
20 lb/1000
sq.ft.
Min.
Interval
Between
Apps. a
Max. Rate
(Days)
Not
specified
Not
specified
Not
specified
Not
specified
NOt
specified
Not
Specified
Not
specified
Not
specified
Not
specified
Not
specified
U
Hot
specified
Restricted
Entry
Interval
(Hours)












Use Limitations













-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP



SODIUM TETRABORATE DECAHTORATE (CHEMICAL 011102)
Void treatment. When needed, Duster
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
AN 1 HAL KENNELS/SLEEPING QUARTERS (COMMERCIAL) USE GROUP: INDOOR NOW- FOOD
COMMERCIAl/lNSmOTIQNAL/INDUSTRlAL PREHISES/EOUIPHEMT (INDOOR) USE GROUP: INDOOR NOK-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES t HUMAN/ VETER I MART) USE GROUP: INDOOR MEDICAL
HOUSEHOLD; DOME STIC DWELLINGS USE GROUP; INDOOR RESIDENTIAL
SPECIALIZED ANIMALS USE GROUP: INDOOR NON-FOOD
Wood protection treatment by pressure, Uhen needed, Unspecified
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS USE GROUP: TERRESTRIAL NON-FOOD
Form




CR






sc/s

Maximum
Application
Rate


(ai)
Not
quantified





.2 Ib/gal

Kin.
Interval
Between
Apps, a
Max. Rate
(Days)
Not
speci f i ed





Not
specified
Restricted
Entry
Interval


(Hours)









Use Limitations













Abbrev i at i ons
   Header:   max.  = maximum;  ruin.  = minimm;  apps. = applications;
   Form:   B/L  =  Bait/Liquid; B/S  = Bait/Solid; RTLJ = Liquid-Ready to Use; SC/S = Soluble Concentrate/Solid;  SC/L = Soluble Concentrate/Liquid
   Rate:   ai = active ingredient; Ib = pound; sq.ft. = square foot; Not quantified application rates include the following terminotogy:  small amount, complete
   coverage, uniform coverage,  apply evenly, think film, thoroughly spray, spray surfaces until wet, course  spray, course wetting spray, spray liberally, apply
   liberally,  etc.
The maximum number of applications and  the maximum number of applications at the maximum rate  is  not specified and has not been included.

-------

-------
APPENDIX A - Use patterns subject to reregistration for: CASE <0024>, 
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
DISODIUH OCTABORATE TETRAHYDRATE (CHEMICAL 011103)
Animal bedding treatment, When needed, Sprayer
PET LIVING/SLEEPING QUARTERS USE GROUP: IHDOOR RESIDENTIAL
Compost treatment, Uhen needed, By hand or Dust gun
COMPOST/COMPOST PILES
Dip, When needed. Unspecified
WOOD PROTECTION TREATMENT TO AQUATIC STRUCTURES/ITEMS USE GROUP: AQUATIC NON-FOOD OUTDOOR
Indoor premise treatment, When needed; By hand
HOUSEHOLD/DOMESTIC DWELLINGS 1 UDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
Indoor premise treatment, When needed; Sprayer
HOUSEHOLD/DOMESTIC DUELLINGS IHDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
Manure treatment, When needed, By hand or Dust gun
MANURE USE GROUP: TERRESTRIAL FOOD 4 FEED CROP
POULTRY (EGG/HEAT) USE GROUP: IMDOOR FOOD
Mop, When needed. Hop
COMMERCIAL TRANSPORTATION FACILITIES- -FEED/FOOD EMPTY USE GROUP: IHDOOR FOOD
FOOD/GROCERY/MARKET I HG/STQRAGE/D I SIR IBUTIOH FACILITY PREMISE USE GROUP: INDOOR FOOD
ANIMAL KENMELS/SLEEPING QUARTERS  USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/1NDUSTR1AL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS USE GROUP: INDOOR FOOD + INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS IMDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
SEWAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
SPECIALIZED ANIMALS USE GROUP INDOOR NON-FOOD
Mop, Uhen needed, Mop
COMMERCIAL STORAGES/WAREHOUSES PREMISES {INDOOR} USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS USE GROUP: INDOOR FOOD + INDOOR NON-FOOD
FOOD/GROCERY/MARKET 1UG/STORAGE/D1STR I BUTION FACILITY PREMISE USE GROUP: INDOOR FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUHAN/VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DWELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
Nonsoil contact norvfumigation, When needed. Brush or Sprayer
WOOD PROTECTION TREATMENT TO AQUATIC STRUCTURES/ ITEMS USE GROUP: AQUATIC NON-FOOD OUTDOOR
Nonsoil contact nonf Litigation, Uhen needed, Brush
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS INDOOR USE GSOUP: INDOOR RESIDENTIAL
Nonsoil contact nonfmnigation, When needed, Brush
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS INDOOR USE GROUP: IMDOOR RESIDENTIAL
Form
sc/s
sc/s
sc/s
sc/s
sc/s
sc/s
sc/s
sc/s
sc/s
SC/L
sc/s
Maximum
Appl i cat ion
Rate
(ai)
.74 Ib/gal
19.6 Lb/
1000 sq.ft.
9.6 Lb/1000
sq.ft.
2.97 Lb/
100D sq.ft.
4.45 Lb/
1000 sq.ft.
19.6 Lb/
TOGO sq.ft.
4 oz/pail of
uater
0.061 Ib/gal
9.8 lb/1000
sq.ft.
2 part/1000
sq.ft.
6.53 lb/1000
sq.ft.
Min.
interval
Between
Apps. a
Max. Rate
(Days)
Not
specified
Hot
specified
Mot
specified
Nat
specified
Not
specified
Not
specified
1
As needed
Hot
specified
Hat
specified
Not
specified
Restricted
Entry
Interval
(Hours)











Use Limitations












-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
D I SODIUM OCTABORATE TETRAHTDRATE (CHEMICAL 011103)
Nonsoil contact nonfumigation, Uhen needed, Brush
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS OUTDOOR USE GROUP: OUTDOOR RESIDENTIAL
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS 
-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
DISOOIUH OCTABORATE TETftAHYDRATE (CHEHICAl 011103}
Nonsoi 1 contact nonfumigation. When needed, Unspecified
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS INDOOR USE GROUP: INDOOR RESIDENTIAL
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS OUTDOOR USE GROUP: OUTDOOR RESIDENTIAL
Nonsoi I contact nonfunigation. When needed. Unspecified
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Outdoor general treatment, When needed, Sprayer
REFUSE/SOLID WASTE SITES < OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
Outdoor premise treatment, When needed, By hand or Dust gun
ANIMAL KENNELS/SLEEPING QUARTERS (INDOOR) USE CROUP: TERRESTRIAL NON-FOOD
Outdoor premise treatment, When needed, Sprayer
ANIMAL KENNELS/SLEEPING QUARTERS (INDOOR) USE GROUP: TERRESTRIAL NON-FOOD
Outdoor treatment, When needed. By hand or Dust gun
REFUSE/SOLID WASTE SITES {OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
Shampoo, When needed. Shampoo machine
HOUSEHOLD/DOMESTIC DUELLINGS CONTENTS USE GROUP: INDOOR RESIDENTIAL
Soil contact nonfumigation, When needed. Injection
WOOD PROTECTION TREATMENT TO AQUATIC STRUCTURES/ITEMS USE GROUP: AQUATIC NON-FOOD OUTDOOR
Soil contact nonfumigation, When needed. Injection
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS INDOOR USE GROUP: INDOOR RESIDENTIAL
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS OUTDOOR USE GROUP: OUTDOOR RESIDENTIAL
Soil contact nonfunigation, When needed. Injection
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Spot treatment. When needed. By hand
HOUSEHOLD/DOMESTIC DUELLINGS CONTENTS USE GROUP: INDOOR RESIDENTIAL
Spot treatment. When needed. Carpet steam cleaner
HOUSEHOLD/DOMESTIC DUELLINGS CONTENTS USE GROUP: INDOOR RESIDENTIAL
Spot treatment. When neede, Shampoo machine or Sprayer
HOUSEHOLD/DOMESTIC DWELLINGS CONTENTS USE GROUP: IMDCOR RESIDENTIAL
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
Spot treatment, When needed. Sprayer
PET LIVING/SLEEPING QUARTERS USE GROUP: INDOOR RESIDENTIAL
Wood protection treatment by pressure, When needed, Unspecified
WOOD PROTECTIOM TREATMENT TO FOREST PRODUCTS USE GROUP: TERRESTRIAL NON-FOOD
Form
SC/S
sc/s
SC/S
sc/s
sc/s
sc/s
sc/s
SC/L
SC/L
SC/L
SC/S
sc/s
sc/s
sc/s
sc/s
Maximum
Application
Rate
(ai)
.031 (b/
sq.ft.
.98 Ib/gal
19.6 lb/1000
sq.ft.
49 lb/1000
sq.ft.
44.1 Ibf
1000 sq.ft.
19.6 lb/1000
sq.ft.
2.97 lb/1000
sq.ft.
.096 gal/
1000 cu. in.
.320 gat/
1000 cj. in.
.187 gal/
1000 cu. in.
2.97 Ibf
1000 sq.ft.
3.27 Ibf
1000 sq.ft.
4.46 Ibf
1000 sq.ft.
.74 Ib/gal
Not
quantified
Min.
Interval
Between
APPS. a
Max. Rate
(Days)
Not
specified
Not
specified
Not
specified
30
2
Not
specified
Not
specified
Not
specified
Not
specified
Not
specified
Not
specified
Not
spec i f i ed
Not
specified
Not
specified
Not
specified
Restricted
Entry
Interval
(Hours)















Use Limitations
















-------
Abbreviations used
   Header:  max.  = maximum;  min.  = mininun; apps. = applications
   Form:  SC/S  =  Soluble  Concentrate/Solid;  SC/L = Soluble  Concentrate/Liquid
   Rate-  ai  =  active ingredient;  sec = secondCs); Sb = pound; A = acre; gal = gallons); sq.ft. = square foot;  cu.in.  = cubic  inches; Not quantified application rates
   include  the  following  terminology:  smalt amount,  complete coverage, uniform coverage, apply evenly, think film,  thoroughly  spray, spray surfaces until wet,  course
   spray, course  wetting  spray,  spray liberally, apply liberally, etc.

The maximum number of applications and the maximum number of applications at the maximum rate is not  specified  and has  not been included.

-------
APPENDIX A - Use patterns subject to reregistration for: CASE <0024>, 
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
Dt SODIUM OCTABORATE ANHTDMUS (CHEHICAL 011107)
Nonsoil contact nonfumigation. When needed. By hand
HOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS INDOOR USE GROUP: INDOOR RESIDENTIAL
WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS OUTDOOR USE GROUP: OUTDOOR RESIDENTIAL
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE CROUP: TERRESTRIAL NON-FOOD
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (UNSEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Form
1
CR
Maximum
Application
Rate
(ai>
,26
Lb/cu.ft.
Hin.
Interval
Between
Apps. 9
Max. Rate
(Days)
Not
specified
Restricted
Entry
Interval
(Hours)

Use Limitations

Abbreviations used
   Header:  max.  = msximun; imn.  =  mini mum; apps. = applications
   Form:  CR  = Crystalline
   Rate:  ai  = active ingredient; sec  =  seeond(s); Ib = pound;  cu.ft.  -  cubic feet;  Not quantified
The maximum number of applications and the maximum number of applications at the maximum rate is not  specified and has not been included.

-------

-------
APPENDIX A - Use patterns subject to reregistration for: CASE <0024>, 
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
SODIUM TETRABORATE PEHTAHTDRATE (CHEMICAL 0111103
Broadcast, When needed. Granule applicator
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
NONACR I CULTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NON-FOOD CROP
Broadcast, Fall or Winter or When needed. By hard or Spreader or Unspecified
SITE NOT SPECIFIED
Crack & crevice. When needed. Bulbous duster
EATING ESTABLISHMENTS FOOD HANDLING AREAS (FOOD CONTACT} USE GROUP: INDOOR FOOD
FOOD PROCESSING PLANT PREMISES (NONFOOD CONTACT) USE GROUP: INDOOR FOOD
FOOD/GROCERY/MARKETING/STORAGE/D1STRIBUT10N FACILITY PREMISE USE GROUP; INDOOR FOOD
Indoor general surface treatment. When needed; Squeeze applicator
COMMERCIAL TRANSPORTATION FACI LITIES--FEED/FOOD EMPTY USE GROUP: INOOOR FOOD
FOOD PROCESSING PLANT NON-FOOD HANDLING AREAS USE GROUP; INDOOR FOOD
FOOD/GROCERY/MARKETING/STORAGE/DISTRIBUTION FACILITY PREMISES USE GROUP: INDOOR FOOD
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
COMMERCIAL TRANSPORTATION FACI LITIES--NONFEED/NONFOOD USE GROUP: INDOOR NON-FOOD
COMMERClAL/INSTITUTIONAL/lNDUSTfUAL PREMISES/EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
EATING ESTABLISHMENTS NON-FOOD AREAS (NONFOOD CONTACT) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/ VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSEHOLD/DOMESTIC DUELLINGS INDOOR PREMISES USE GROUP: INDOOR RESIDENTIAL
Prepaying treatment, When needed, By hand or Spreader
PAVING AREAS (PRIVATE ROADS/SI DEUALKS) USE GROUP: TERRESTRIAL NON-FOOD
Prepaying treatment, When needed. Unspecified
PAVING AREAS (PRIVATE RGADS/S JDEUALKS) USE GROUP: TERRESTRIAL NON-FOOD
Spot treatment, When needed, Unspecified
EATING ESTABLISHMENTS FOOD SERVING AREAS (FOOD CONTACT) USE GROUP; INDOOR FOOD
Spot treatment, When needed. Unspecified
SITE NOT SPECIFIED
Void treatment, When needed. Duster
COMMERCIAL TRANSPORTATION FACILITIES-- FEED/FOOD EMPTY USE GROUP: INDOOR FOOD
HOUSEHOLD /DOMESTIC DUELLINGS INDOOR FOOD HANDLING AREAS USE GROUP: INDOOR FOOD
COMMERCIAL TRANSPORTATION FACILITIES--NONFEED/HONFOOD USE GROUP: INDOOR NON-FOOD
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES /EQUIPMENT (INDOOR) USE GROUP: INDOOR NON-FOOD
HOSPITALS/MEDICAL INSTITUTIONS PREMISES (HUMAN/VETERINARY) USE GROUP: INDOOR MEDICAL
HOUSE HOLD /DOME STIC DUELLINGS INDOOR PREMISES USE GROUP: INOOOR RESIDENTIAL
Water treatment. Initial or Winterizing; Unspecified
SWIMMING POOL WATER SYSTEMS
Form
G
G
D
D
G
G
D
G
D
SC/S
Maximun
Appl i cat ion
Rate

-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP


SOOIUH TETRABORATE PEMTANYDMTE (CHEMICAL 011110)
Water treatment. Subsequent /maintenance; Unspecified
Form



SC/S
Maximum
Application
Rate


(ai)
0.0995 lb/
1000 gal
Min.
Interval
Between
Apps. 3
Hex. Rate
(Days)
Mot
specified
Restricted
Entry
Interval


(Hours)

Use Limitations




Abbreviations used
   Header:  max.  = maximum;  min.  = minimum; apps. = applications
   Form:  D = Oust;  G = Granular; SC/S = Soluble Concentrate/Solid
   Rate-
   terminology
   spray, spray liberally, apply liberally, etc.
                                                             _         .         ,.*,,-
sq.ft.  = square foot;  gal = gallon(s); Not quantified application rates include the following
                                                                                                                                                         .
         ai = active  ingredient;  sec = second(s);  lb = pound; A = acre; sq.ft. = square foot; gal = gallon(s);  Not quantie   appication rates incue   e  oowing
         logy:   small  amount, conplete coverage, uniform coverage, apply evenly, think film, thoroughly spray,  spray surfaces  until wet, course spray, course wetting
The maximum number of applications and the maximum number of applications at the maximum rate  is  not  specified and has not been included.

-------
APPENDIX A - Use patterns subject to reregistration for: CASE <0024>, 
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP
SODIUM TETftABORATE (ANHYDROUS) (CHEMICAL 011112)
Broadcast, Fait or When needed or Winter, By hand or Spreader
AGRICULTURAL UNCULTIVATED AREAS USE GROUP: TERRESTRIAL NON-FOOD CROP
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
NOHAGRI CULTURAL RIGHTS-aF-WAY/FENCEROWS/HEDGEROUS USE GROUP: TERRESTRIAL NON-FOOD CROP
Bait application, Uhen needed. Unspecified
SITE HOT SPECIFIED
Prepaying treatment, When needed, Lou pressure
PAVED AREAS (PRIVATE ROADS /SIDEWALKS) USE GROUP: TERRESTRIAL WON- FOOD
Prepaying treatment, When needed, Unspecified
PAVED AREAS (PRIVATE ROADS /SIDEWALKS 3 USE GROUP: TERRESTRIAL MOW -FOOD
Spray, Foliar, Sprayer
ORNAMENTAL AND/OR SHADE TREES USE GROUP: ittDOOR RESIDENTIAL
Spray, Foliar Sprayer
ORNAMENTAL HERBACEOUS PLANTS USE GROUP: INDOOR RESIDENTIAL
ORNAMENTAL UON FLOWER ING PLANTS USE GROUP: INDOOR RESIDENTIAL
ORNAMENTAL WOODY SHRUBS AMD VINES USE GROUP: INDOOR RESIDENTIAL
Spray treatment, Uhen needed. Knapsack sprayer or Power sprayer
AGRICULTURAL UNCULTIVATED AREAS USE GROUP: TERRESTRIAL NON-FOOD CROP
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
NONAGR1CULTURAL R1GHTS-OF-WAY/FENCEROWS/WEOGEROWS USE GROUP: TERRESTRIAL NON-FOOD CROP
RECREATIONAL AREAS USE GROUP: TERRESTRIAL NOH-FOOD
Spot treatment, Uhen needed, Unspecified
AGRICULTURAL UNCULTIVATED AREAS USE GROUP: TERRESTRIAL NON-FOOD CROP
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
NONAGRICULTURAL RIGHTS-OF- WAY/FENCEROUS/HEOGEROWS USE GROUP: TERRESTRIAL NON-FOOD CROP
Form
G
B/L
SC/L
G
EC
EC
SC/L
C
Maximum
Application
Rate

-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP



SODIUM HETABORATE (CHEMICAL 011104}
Broadcast, Uhen needed, Shaker can
NONAGRI CULTURAL OUTDOOR BUILDINGS/STRUCTURES USE GROUP: TERRESTRIAL NON-FOOD
NONAGRICULTURAL RIGHTS-OF-WAY/FENCEROWS/HEDCEROWS USE GROUP: TERRESTRIAL NON-FOOD CROP +
OUTDOOR RESIDENTIAL
PATHS/PATIOS USE GROUP: TERRESTRIAL NON-FOOD +• OUTDOOR RESIDENTIAL + OUTDOOR RESIDENTIAL
RECREATIONAL AREAS USE GROUP: TERRESTRIAL NON-FOOD
Broadcast or Spray, When needed, Spreader or Sprayer
AIRPORTS/LANDING FIELDS USE GROUP: TERRESTRIAL NOW -FOOD CROP
DRAINAGE SYSTEMS USE GROUP: AQUATIC NOH-FOOD INDUSTRIAL
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
NONAGR I CULTURAL RIGHTS-OF-UAV/FENCEROWS/HEDGEROHS USE CROUP: TERRESTRIAL NON-FOOD CROP
NONAGR I CULTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NON-FOOD CROP
NONAGR] CULTURAL OUTDOOR BUILDINGS/STRUCTURES USE GROUP: TERRESTRIAL NON-FOOD
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD
Broadcast, Utien needed, Stiaker can
REFUSE/SOLID WASTE SITES (OUTDOOR) USE GROUP: TERRESTRIAL MOM-FOOD
Broadcast, When needed Spreader
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL MON-FOOD
NOMAGRICULTURAL RIGHTS-OF-MAY/FENCEROWS/HEOGESOUS USE GROUP: TERRESTRIAL NON-FOOD CROP
NONAGRIOJLTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NON-FOOD CROP
PAVED AREAS {PRIVATE ROADS/SIDEUALKS) USE GROUP: TERRESTRIAL NON-FOOD
Broadcast, When needed Spreader
REFUSE/SOLID HASTE SITES (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
Dip, Not applicable, Tank
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
Edging treatment. When needed. Squeeze applicator
PATHS/PATIOS USE GROUP: TERRESTRIAL NOH-FOOD + OUTDOOR RESIDENTIAL
PAVED AREAS (PRIVATE ROADS/S 1 DEWALCS) USE GROUP: TERRESTRIAL NON-FOOD + OUTDOOR
RESIDENTIAL
Prepaving treatment, Uhen needed, Shaker can
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON- FOOD
Prepaving treatment, When needed, Spreader or Sprayer
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD
Prepaving treatment, Uhen needed, Sprayer
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NOH-FOOD
Form




G





G






G

WP/D




G
SC/L

RTU


G
G
RTU
Maximum
Application
Rate



-------
Application Type, Application Timing, Application Equipment
USE SITE /USE GROUP
SODIUM HETABORATE (CHEMICAL 011104)
Spot treatment, When needed, Sprinkler can
DRAINAGE SYSTEMS USE CROUP: AQUATIC NON-FOCO INDUSTRIAL
NONAGR I CULTURAL OUTDOOR BUILDINGS/STRUCTURES USE GROUP: TERRESTRIAL WON -FOOD
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD + OUTDOOR
RESIDENTIAL
REFUSE/SOLID HASTE SITES (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
Spray, When needed, Sprayer
AGRICULTURAL UNCULTIVATED AREAS USE CROUP: TERRESTRIAL MOM-FOOD CROP
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD
Spray, When needed, Sprayer
DRAINAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
NONAGR I CULTURAL RIGHTS-OF-UAY/FENCEROUS/HEDGEROWS USE GROUP: TERRESTRIAL NON-FOOD CROP
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD
Spray, When needed. Sprayer
NOHAGR I CULTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NON-FOOD CROP
Spray, When needed, Sprayer
AIRPORTS/LANDING FIELDS USE GROUP: TERRESTRIAL NOH-FOOD
DRAINAGE SYSTEMS USE GROUP: AQUATIC MOM- FOOD INDUSTRIAL
MONAGR I CULTURAL OUTDOOR BUILDINGS/STRUCTURES USE GROUP: TERRESTRIAL WON- FOOD
REFUSE/SOLID WASTE SITES (OUTDOOR) USE GROUP: TERRESTRIAL WON- FOOD
Spray, When needed. Sprayer
DRAINAGE SYSTEMS USE CROUP: AOUATIC NON-FOOD INDUSTRIAL
NONAGR I CULTURAL OUTDOOR BUILDINGS/STRUCTURES USE GROUP: TERRESTRIAL NON-FOOD
NONAGR I CULTURAL RIGHTS-OF-UAY/FENCEROWS/HEOGEROWS USE GROUP: TERRESTRIAL NON-FOOD CROP
NONAGR I CULTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NON-FOOD CROP
Spray, Uhen needed, Power sprayer
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
NONAGR I CULTURAL RIGHTS-OF-UAY/FENCEROWS/HEDGEROWS USE GROUP: TERRESTRIAL NON-FOOD CROP
NONAGRICULTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NON-FOOD CROP
Spray, Uhen needed. Sprayer
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
Spray, When needed. Sprayer
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
NONAGRICULTURAL RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS USE GROUP: TERRESTRIAL NON-FOOD CROP
NONAGRICULTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NON-FOOD CROP
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL NON-FOOD
Spray, Uhen needed, Sprayer
PATHS/PATIOS USE GROUP: TERRESTRIAL HON-FOOO <• OUTDOOR RESIDENTIAL
Form
G
SC/L
RTU
RTU
G
SC/L
G
SC/L
WP/0
G
Maximum
Application
Rate
(ai)
19.95 lb/
1000 sq.ft.
4. 38 lb/
1000 sq.ft.
4.34 lb/
1000 sq.ft.
2.94 lb/
1000 sq.ft.
£7.2 lb/
1000 sq.ft.
20.25 lb/
1000 sq.ft.
320 Ib/A
7 lb/1000
sq.ft.
9.4 lb/1000
sq.ft.
19.95 lb/
1000 sq.ft.
Hin.
Interval
Between
Apps. a
Max. Rate
(Days)
Not
specified
Not
specified
Not
specified
Not
specified
Not
specified
NOt
specified
Not
specified
Not
specified
Not
specified
Hot
specified
Restricted
Entry
Interval
(Hours)










Use Limitations











-------
Application Type, Application Timing, Application Equipment
USE SITE/USE GROUP


SODIUM HETABORATE (CHEMICAL 011104)
Spray, Hot applicable. Sprayer
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NON-FOOD
WOOD PROTECTION TREATMENT TO FOREST PRODUCTS (SEASONED) USE GROUP: TERRESTRIAL NOM-FOOD
Sprinkler, When needed. Sprinkler can
AGRICULTURAL UNCULTIVATED AREAS USE GROUP: TERRESTRIAL NON-FOOD CROP
INDUSTRIAL AREAS (OUTDOOR) USE GROUP: TERRESTRIAL NON-FOOD
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE GROUP: TERRESTRIAL MON-FOOD RESIDENTIAL
Sprinkler, When needed. Sprinkler can
DRAINAGE SYSTEMS USE GROUP: AQUATIC NON-FOOD INDUSTRIAL
NON AGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES USE GROUP: TERRESTRIAL NON-FOOD
NONAGR I CULTURAL RIGHTS-OF-UArVFENCEROUS/HEDGEflOUS USE GROUP: TERRESTRIAL NON-FOOD CROP
NOHAGRI CULTURAL UNCULTIVATED AREAS/SOILS USE GROUP: TERRESTRIAL NON-FOOD CROP 	
Sprinkler, When needed. Sprinkler can
PATHS/PATIOS USE GROUP: TERRESTRIAL NOK-FOOD + OUTDOOR RESIDENTIAL
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) USE 5ROUP: TERRESTRIAL NON-FOOD + OUTDOOR
RESIDENTIAL
RECREATIONAL AREAS USE GROUP: TERRESTRIAL NON-FOOD
Form



SC/L

SC/L


SC/L



SC/L



Max i man
Application
Rate


(ai)
0.3 gal
product/gal

4.38 lb/
1000 sq.ft.


20 lb/ 1000
sq.ft.



2.73 lb/
1000 sq.ft.



Min.
I nterval
Between
Apps. 3
Max. Rate
(Days)
Hot
specified

Not
specified


Not
specified



Not
specified



Restricted
Entry
Interval


(Hours)












^=^^^^^=
Use Limitations















=s=^^= . . —
Abbreviations used
   Header:   max.  = maximum; nin.  = minimum; apps. = applications                                                            ,_,„.,,,  ..
   Form:   G = Granular; RTU = Ready to Use; SC/S = Soluble Concentrate/Solid; SC/L = Soluble Concentrate/Li quid; WP/D = Hettable Powder/Dust
   Rate:   ai = active ingredient; lb = pound; A = acre; sq.ft.  = square foot; gal = gallon(s)

The maximum number  of  applications and the maximum number of applications  at the maxinum rate is not specified and has not been included.

-------
              APPENDIX B
Table of the Generic Data Requirements
     and Studies Used to Hake the
       Reregistration Decision

-------
                              GUIDE TO APPENDIX B
       Appendix B contains listings of data requirements which support the reregistration for
the pesticide Boric Acid and Its Sodium Salts covered by this Reregistration Eligibility Decision
Document. It contains generic data requirements that apply to Boric Acid and Its Sodium Salts
in all products,  including data requirements for which a "typical formulation" is the test
substance.

       The data table is organized in the following format:

       1.     Data Requirement (Column 1).  The data requirements are listed in the order in
             which they appear in 40 CFR,  Part 158. The reference numbers accompanying
             each test refer to the test protocols set in the Pesticide Assessment Guidelines,
             which are available from the National Technical Information Service, 5285 Port
             Royal Road, Springfield, VA  22161  (703) 487 - 4650.

       2.     Use  Pattern (Column  2).  This column indicates the use patterns for which the
             data requirements apply. The following letter designations are used for the given
             use patterns:

                    A      Terrestrial food
                    B      Terrestrial feed
                    C      Terrestrial non-food
                    D      Aquatic food
                    E      Aquatic non-food outdoor
                    F      Aquatic non-food industrial
                    G      Aquatic non-food residential
                    H      Greenhouse food
                    I      Greenhouse non-food
                    J      Forestry
                    K     Residential
                    L     Indoor food
                    M     Indoor non-food
                    N     Indoor medical
                    0     Indoor residential

       3.     Bibliographic citation (Column 3).  If the Agency has acceptable data in its files,
             this  column lists the identifying number of  each study.  This normally is the
             Master Record Identification (MRID) number, but may be a "GS" number if no
             MRID number has been assigned,  or  a scientific study  available in the public
             literature.   Refer to the Bibliography  appendix  for the citation of the study or
             publication.

-------
                                 APPENDIX B
                    Generic Data Requirements for Reregistration of
                                      BOMCACID
                        Data Citations Supporting Reregistration
Guideline  Title of Study
                                Use Patterns    Bibliographic Citation
PRODUCT CHEMISTRY
61-1
61-2

61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
Chemical Identify
Starting Material and Manufacturing
Process
Formation of Impurities
Preliminary Analysis
Certification of Limits
Analytical Method
Color
Physical State
Odor
IVIett ing Point
Boiling Point
Density
All
All

All
All
All
All
Alt
All
All
All
All
All
42931801
42931801

42931801
42931801
42931801
42931801
42931802
42931802
42931801
42931801
NOT APPLICABLE
42931801

-------
         APPENDIX B
Generic Data Requirements for Reregistration of
             BORIC ACID
   Data Citations Supporting Reregistration
Guideline Tide of Study
PRODUCT CHEMISTRY
63-8 Solubility
63-9 Vapor Pressure
63-10 Dissociation Constant
63-11 Octanol/Water Partition
63-12 pH
63-13 Stability
Use Patterns

Alt
All
All
All
All
All
Bibliographic Citation

42931801
42931804
DATA GAP
42931801
42931804
42931801

-------
                                 APPENDIX B
                   Generic Data Requirements for Reregistration of
     SODIUM TETRABORATE DECAHYDRATE (BORAX DECAHYDRATE)
                        Data Citations Supporting Reregistration
Guideline   Title of Studv
                                Use Patterns    Bibliographic Citation
PRODUCT CH
61-1
61-2

61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
Chemical Identity
Starting Materials and Manufacturing
Process
Formation of Impurities
Preliminary Analysis
Certification of Limits
Analytical Method
Color
Physical State
Odor
Melting Point
Boiling Point
Density
Solubility
Vapor Pressure
Dissociation Constant
All
All

All
All
All
All
All
All
All
All
All
All
All
All
All
42931801
42931801

42931801
42931801
42931801
42931801
42931801
42931801
42931801
42931801
NOT APPLICABLE
42931801
42931801
42931801
DATA GAP

-------
                           APPENDIX B
                Generic Data Requirements for Reregistration of
    SODIUM TETRABORATE DECAHYDRATE (BORAX DECAHYDRATE)
                   Data Citations Supporting Reregistration
Guideline  Tide of Study               Use Patterns   Bibliographic Citation
PRODUCT CHEMISTRY
63-11      Octanol/Water Partition              All     DATA GAP
63-12      pH                           All     42931801
63-13      Stability                       All     42931801

-------
                               APPENDIX  B
                   Generic Data Requirements for Reregistration of
    SODIUM TETRABORATE PENTAHYDRATE (BORAX PENTAHYDRATE)
                       Data Citations Supporting Reregistration
Guideline  Title of Study
                               Use Patterns    Biblio&raDhic Citation
PRODUCT CHEMISTRY
61-1
61-2

61-3
62-1
62-2
62-3
63-2
63-3
634
63-5
63-6
63-7
63-8
63-9
63-10
Chemical Identity
Starting Materials and Manufacturing
Process
Formation of Impurities
Preliminary Analysis
Certification of Limits
Analytical Method
Color
Physical State
Odor
Melting Point
Boiling Point
Density
Solubility
Vapor Pressure
Dissociation Constant
All
All

All
All
AH
All
All
All
All
All
All
All
All
All
All
42931801, 42931804
42931804

42931804
42931801
42931801
42931801
42931804
42931804
42931804
42931804
NOT APPLICABLE
42931804
42931804
42931804
DATA GAP

-------
                      APPENDIX  B
            Generic Data Requirements for Reregistration of
SODIUM TETRABORATE PENTAHYDRATE (BORAX PENTAHYDRATE)
               Data Citations Supporting Reregistration
Guideline Title of Stud
                              Use Patterns   Bibliorahic Citation
PRODUCT CHEMI

63-11     OctanoI/Watcr Partition

63-12     pH

63-13     Stability
                                All     DATA GAP

                                AU     42931804

                                All     42931804

-------
                                 APPENDIX B
                    Generic Data Requirements for Reregistration of
                 SODIUM TETRABORATE (ANHYDROUS BORAX)
                        Data Citations Supporting Reregistration
Guideline  Title of Study
                                Use Patterns     Bibliographic Citation
61-1
61-2

61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
Chemical Identity
Starting Materials and Manufacturing
Process
Formation of Impurities
Preliminary Analysis
Certification of Limits
Analytical Method
Color
Physical State
Odor
Melting Point
Boiling Point
Density
Solubility
Vapor Pressure
Dissociation  Constant
All
All

All
All
All
All
All
All
All
All
All
All
All
All
All
42931804
42931804

42931804
42931801
42931801
42931801
42931804
42931804
42931804
42931801, 42931804
NOT APPLICABLE
42931801, 42931804
42931801, 42931804
42931804
DATA GAP

-------
                           APPENDIX B
                Generic Data Requirements for Reregistration of
              SODIUM TETRABORATE (ANHYDROUS BORAX)
                   Data Citations Supporting Reregistration
Guideline  Title of Study               Use Patterns   Bibliographic Citation

PRODUCT CHEMISTRY

63-11      OctanolAVater Partition              All     DATA GAP

63-12      pH                          All     42931801

63-13      Stability                       All     42931801

-------
                                APPENDIX B
                   Generic Data Requirements for Reregistration of
                   DISODIUM OCTABORATE TETRAHYDRATE
                       Data Citations Supporting Reregistration
Guideline  Title of Study
                               Use Patterns    Bibliographic Citation
PRODUCT CHEMISTRY
61-1
61-2

61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
Chemical Identity
Starting Materials and Manufacturing
Process
Formation of Impurities
Preliminary Analysis
Certification of Limits
Analytical Method
Color
Physical State
Odor
Melting Point
Boiling Point
Density
Solubility
Vapor Pressure
Dissociation Constant
All
All

All
All
All
All
All
All
All
All
All
All
All
All
All
42931804
42931804

42931804
DATA GAP
42931804
42931804
42931804
42931804
42931804
42931804
NOT APPLICALBE
42931804
42931804
42931804
DATA GAP

-------
          APPENDIX B
Generic Data Requirements for Reregistration of
DISODIUM OCTABORATE TETRAHYDRATE
   Data Citations Supporting Reregistration
Guideline Title of Stud
                  Use Patterns   Bibliorahic Citation
PRODUCT CHEMISTRY
63-11      OctanoIAVater Partition
63-12      pH
63-13      Stability
                                    All
                                    All
                                    All
                            DATA GAP
                            42931804
                            42931804

-------
                                APPENDIX B
                   Generic Data Requirements for Reregistration of
                     DISODIUM OCTABORATE (ANHYDROUS)
                       Data Citations Supporting Reregistration
Guideline  Title of Study
                               Use Patterns
          T CHEMISTRY
61-3
62-1
62-2
62-3
63-2
63-3
634
63-5
63-6
63-7
63-8
63-9
Starting Materials and Manufacturing
Process
Formation of Impurities
Preliminary Analysis
Certification of limits
Analytical Method
Color
Physical State
Odor
Melting Point
Roiling Point
Density
Solubility
Vapor Pressure
All
All

All
All
All
All
All
All
All
All
All
All
All
All
40534001
40534001

40534001
40534002
40534002
40534002
40534003
40534003
40534003
40534003
NOT APPLICABLE
40534003
40534003
40534003

-------
         APPENDIX B
Generic Data Requirements for Reregistration of
 DISODIUM OCTABORATE (ANHYDROUS)
   Data Citations Supporting Reregistration
Guideline Title of Study
PRODUCT nHKMTSTRY
£3-10 Dissociation Constant
63-11 Octanol/Water Partition
63-12 pH
63-23 Stability
Use Patterns

All
All
All
All
Bibliographic

40534003
40534003
40534003
40534003
Citation






-------
                                  APPENDIX B
                    Generic Data Requirements for Reregistration of
                                SODIUM METABORATE
                        Data Citations Supporting Reregistration
Guideline  Title of Study
                                 Use Patterns    Bibliographic Citation
PRODUCT  CHEMISTRY
61-1
61-2

61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-ti
63-7
63-8
63-9
63-10
Chemical Identity
Starting Materials and Manufacturing
Process
Formation of Impurities
Preliminary Analysis
Certification of Omits
Analytical Method
Color
Physical State
Odor
Melting Point
Boiling Point
Density
Solubility
Vapor Pressure
Dissociation Constant
All
All

All
All
All
AH
All
AU
All
All
All
All
All
All
All
42931801, 42931804
42931804

42931804
42931801
42931801
42931801
42931801
42931801
42931801
42931801
NOT APPLICABLE
42931801, 42931804
42931801, 42931804
42931804
DATA GAP

-------
                            APPENDIX B
                Generic Data Requirements for Reregistration of
                          SODIUM METABORATE
                    Data Citations Supporting Reregistration
Guideline  Title of Study                Use Patterns   Bibliographic Citation

PRODUCT CHEMISTRY

63-11      Octanol/Water Partition               All      DATA GAP

63-12      pH                            All      42931804

63-13      Stability                         All      42931801,42931804

-------
                                 APPENDIX  B
                   Generic Data Requirements for Reregistration of
                       BORIC ACID AND ITS SODIUM SALTS
                        Data Citations Supporting Reregistration
Guideline  Title of Studv
                                           Use Patterns    BiblioeraDhic Citation
ECOLOGICAL EFFECTS
           Acute Avian Oral Quail/Duck

           Acute Avian Diet. Quail

           Acute Avian Det. Duck
           Fish Torichy Bluegill

           Fish ToxicUy Rainbow Trout

           Invertebrate Tosicity
           Life-Cycle Aquatic Invertebrates
           Seed Germ./Seedling Emergence

           Vegetative Vigor
7l-2(a)

71-2(b)
72-l(a)

72-l(c)

72-2(a)
123-l(a)

123-i(b)
 A,B,C,D,E,   GS0024-017
   FJ.K
 A,B,C,D,E,   Ace. No. 254367, GS0024-018, GS0024-019
   F.J.K,
A,B,C,D,EJ,K  Ace. No. 254367, GS0024-020, GS0024-021
 A,B,C,D,E,   40594601
   FJ,K,
 A,B,C,D,E,   40594602, GS0024-022
 A,B,C,D,E,   GS0024-023

 A,B,C,D,E,F,   Footnote 1
 A,B,C,D,E,   Data Gap

 A,B,C,D,E,   Data Gap

-------
                                APPENDIX B
                  Generic Data Requirements for Reregistration of
                      BORIC ACID AND ITS SODIUM SALTS
                       Data Citations Supporting Reregistration
Guideline  Title of Study	JMRjiterns   Bibliographic Citation

123-2      Aquatic Plant Growth               A,B,C,D,E,    Data Gap
                                           FJ,K,
     Footnote 1:  Results of scientiflc studies available in the public literature are being used to supplement the boric acid
              and its sodium salts data base because of the reported low toxictty and the limited outdoor use patterns.
              No additional data win be required unties future use dictate otherwise.

-------
          APPENDIX B
Generic Data Requirements for Reregistration of
   BORIC ACID AND ITS SODIUM SALTS
   Data Citations Supporting Reregistration
Guideline
Title of Study
Use Patterns
Bibliographic Citation
TOXICOLOGY
BORIC ACID
81-1
81-2
81-3
81-4
81-5
82-2
83-3(a)
83-3(b)
8^4
84-2(a)
Acute Oral Tox. Rat
Acute Dermal Tox. Rabbit/Rat
Acute Inhalation Tox Rat
Primary Eye Initiation Rabbit
Primary Dermal Irritation
21-Day Dermal RabbhVRat
Teratogenitity - Rat
Teratogenkky - Rabbit
2-Generation Repro - Rat
Gene Mutation - Ames
A,BfC,D,E,F,G,
J,K,L,M,N,O
A,B,C,D,E,F,G,
J,K,L,M,N,O
j,K,L,M,N,b '
J,K,L,M,0
J,K,L,M,N,O '
A,B,C,D,E,F,G,
J,K,L,M,N,O
A,B,D,L
A,B,D,L
A,B,I),L
A,B,C,D,E,F,G,
J,K,L,M,N,0
Ace. No. 246338
Ace. No. 247814
Tox Data Eval Rec (DER) #0053$ 1
Ace. No. 246338
Ace. No, 247814
41861301, DER#9834
417254, 42377101, 41861301 (mice)
42164201, 42164202, DER18719
41589101, DER#8333
42038902

-------
                             APPENDIX B
                 Generic Data Requirements for Reregistration of
                    BORIC ACID AND ITS SODIUM SALTS
                     Data Citations Supporting Reregistration
Guideline  Title of Study                 Use Patterns    Bibliographic Citation

TOXICOLOGY
84~2(b)      Struc. Chrom. Aberration           A,B,C,D,E,F,G,  42038901, DER#9661
844       Other Genotoxic Effects            A,B,C,I),E,F,G,  42038904
                                     J,K,L,M,N,0,

85-1       General Metabolism                A,B,D,L    000005621,000005631,

-------
                                 APPENDIX  B
                   Generic Data Requirements for Rereglstration of
                      BORIC ACID AND ITS SODIUM SALTS
                       Data Citations Supporting Reregistration
Guideline   Title of Study                   Use Patterns    Bibliographic Citation
TOXICOLOGY

SODIUM TETRABOR ATE (ANHYDORUS BORAX) _
81-1        Acute Oral Tax. Rat               A,B,C,D,EfF,G,  40692303
                                          J,K,L,M,N,0
81-2        Acute Dermal Tax. Rabbit/Rat        A,B, C,D,E,F,G,  DER#009301
                                          J,K,L,M,N,0
81-4        Primary Eye Irritation - Rabbit        A,B,C,D,E,F,G,  DER#009301
                                          J,K,L,M,N,0
81-5        Primary Dennal Iritation            A,B,C,D,E,F,G,  DER#009301
                                          J,K,L,M,N,0
82-1        90-Day Feeding                   AfBfC4)»K»F.G»  406923207
                                          J,K,L,M,N,0
82-2        21-Day Dermal - Rabbit/Rat          A,B,C,D,E,F,G,  40692309, 40692308, 40692310, DFJW9301
                                          J,K,L^I,N,0
83-4        2-Geoenitio0 Repra - Rat              A,B,D,L,    40692311, DER#9301

-------
                              APPENDIX  B
                  Generic Data Requirements for Reregistration of
                     BORIC ACID AND ITS SODIUM SALTS
                      Data Citations Supporting Reregistration
Guideline  Title of Study                  Use Patterns    Bibliographic Citation

ENVIRONMENTAL FATE


163-1      Leaching and Adsorption/Desorption    A,B,C,D,E,F,G, 05008133
Because of the relatively small amount of bone acid employed for most uses as a pesticide, and the already significant
amounts of boron present in soil and water, the Agency, at this tune, will not require any additional environmental fate
data.

-------
                              APPENDIX B
                 Generic Data Requirements for Reregistration of
                     BORIC ACm AND ITS SODIUM SALTS
                     Data Citations Supporting Reregistration
Guideline  Title of Study
                             Use Patterns    Bibliographic Citation
RESIDUE
171-4
171-4
 i I MiT> I
Nature of Residue (Metabolism)
 - Plants
 - Livestock
Residue Analytical Method
 - Plant Residues
 - Animal Residues
 - Water Residues
005012937, 005009091, 005008425
005012315

005007137
005007137
005007137

-------

-------
          APPENDIX C
Citations Considered to be Part
       of  the Data Base
   Supporting Reregistration

-------

-------
                       GUIDE TO APPENDIX C
1.   CONTENTS OF BIBLIOGRAPHY.  This bibliography contains
     citations of all studies considered relevant by EPA in
     arriving at the positions and conclusions stated elsewhere
     in the Reregistration Eligibility Document.  Primary sources
     for studies in this bibliography have been the body of data
     submitted to EPA and its predecessor agencies in support of
     past regulatory decisions.  Selections from other sources
     including published literature, in those instances where
     they have been considered, are included.

2.   UNITS OF ENTRY.  The unit of entry in this bibliography is
     called a "study".  In the case of published materials, this
     corresponds closely to an article.  In the case of
     unpublished materials submitted to the Agency, the Agency
     has sought to identify documents at a level parallel to the
     published article from within the typically larger volumes
     in which they were submitted.  The resulting "studies"
     generally have a distinct title (or at least a single
     subject),  can stand alone for purposes of review and can be
     described with a conventional bibliographic citation.  The
     Agency has also attempted to unite basic documents and
     commentaries upon them,  treating them as a single study.

3.   IDENTIFICATION OP ENTRIES.  The entries in this bibliography
     are sorted  numerically by Master Record Identifier, or
     "MRID Number".  This number is unique to the citation, and
     should be uses whenever a specific reference is required.
     It is not related to the six-digit "Accession Number" which
     has been used to identify volumes of submitted studies (see
     paragraph 4(d)(4) below for further explanation).   In a few
     cases, entries added to the bibliography late in the review
     may be preceded by a nine character temporary identifying
     number is also to be used whenever specific reference is
     needed.

4.   FORM OF ENTRY.  In addition to the Master Record Identifier
     (MRID),  each entry consists of a citation containing
     standard elements followed, in the case of material
     submitted to EPA, by a description of the earliest known .
     submission.  Bibliographic conventions used reflect the
     standard of the American National Standards Institute
     (ANSI),  expanded to provide for certain special needs.

     a.   Author.  Whenever the author could confidently be
          identified, the Agency has chosen to show a personal
          author.  When no individual was identified, the Agency
          has shown a identifiable laboratory or testing facility
          as the author.  When no author or laboratory could be
          identified, the Agency has shown the first submitter as
          the author.

-------
b.   Document Date.  The date of the study is taken directly
     from the document.  When the date is followed by a
     question mark, the bibliographer has deduced the date
     from the evidence contained in the document.  When the
     date appears as  (19??), the Agency was unable to
     determine or estimate  the date of the document.

c.   Title.  In some  cases, it has been necessary for the
     Agency bibliographers  to create or enhance a document
     title.  Any such editorial insertions are contained
     between square brackets.

d.   Trailing Parentheses,  For studies submitted to the
     Agency in the past, the trailing parentheses include
      (in addition to  any self-explanatory text) the
     following elements describing the earliest known
     submission:

      (1)  Submission  Date.  The date of the earliest known
          submission  appears immediately following  the word
          "received".

      (2)  Administrative Number.  The next element
          immediately following the word  "under" is the
          registration number, experimental use permit
          number, petition number, or other administrative
          number associated with  the earliest  known
          submission.

      (3)  Submitter.   The  third element  is the submitter.
          When authorship  is de-faulted  to the submitter,
          this element is  omitted.

      (4)  Volume  Identification (Accession Numbers).  The
           final  element  in the trailing  parentheses
           identifies the EPA accession number of  the volume
           in which the original  submission  of the  study
          appears.   The  six-digit accession number follows
           the symbol "COL", which stands for "Company Data
           Library".   This accession number  is in turn
           followed by an alphabetic suffix which shows  the
           relative position of the study within the volume.

-------
                           BIBLIOGRAPHIC CITATIONS
                                      FOR
                      BORIC ACID AND ITS SODIUM SALTS
              REREGISTRATION FJJGIBI1ITY DECISION DOCUMENT
42931800


42931801



42931802



42931803



42931804



GS0024-017



GS0024-018
GS0024-019
GS0024-020
U.S. Borax (1993) Resubmission of Old Product Chemistry Data for
Botates in Support of Registration.  Transmittal of 4 studies.

Handler, R. (1978) Monograph on Borax, Boric Acid and Borates.
Washington, D.C.: Food and Drug Administration.  (FDA Report
Number FDA/BF/-79/6) Original Reference Number 005009134.

Faith, W.L., ed.; Keyes, D.B., Ed; Clark, R.L. (1957). Industrial
Chemicals: P. 156-160: Third Edition: New York, London, Sydney:
John Wiley & Sons,  Original Reference Number 005014487.

May, F.H., Inventor; American Potash & Chemical Corporation (1960)
Process for Producing Pure Boric Acid and Potassium Sulfate.  U.S.
patent 2,948,592.  August  9.  5 pages.

U.S. Borax Research Corporation. (19??)  Boron Compounds (Oxides,
Acid, Borates): P. 67-110 in Kirk-Othmer Encyclopedia of Chemical
Technology, Volume 4, 3rd edition (1978) John Wiley & Sons, Inc.

Fink, R (1982) Acute Oral LD50 for Bobwhite  Quail; Project No. 135-
106; Prepared by Wildlife Intenational Ltd. jfor U.S. Borax, Anahaim,
CA.

Beavers, J.B. January 21, 1984. Fjght-day dietary LC50 - Bobwhite
Quail - Polybor.  Final REport.  TX-82-3.  Prepared by Wildlife
International Ltd, St. Michaels, MD.  Submitted to Borax; Anahaim,
CA.

Beavers, J.B. May 21, 1984.  A Dietary LC50 study on the Bobwhite
with Boric Acid.  Final Report. Project No. 176-102a. Prepared by
Wildlife International, St. Michaels, MD.  Submitted to Kerr McGee
Chemical Corporation. Oklahoma City, OK. EPA Accession Number
254367. (HCOBORO2)

Beavers, J.B. January 21, 1984.  Eight-day dietary LC50 - Mallard
Duck - Polybor.  Final Report. TX-82-4.  Prepared by Wildlife
International., St. Michaels, MD.  Submitted to U.S. Borax; Anaheim,
CA. No EPA Accession Number provided.

-------
GS0024-021
GS0024-022
GS0024-023
GS0024-027
GS0024-028
 GS0024-029
 GS0024-030
Beavers, J.B. May 21,  1984.  A dietary LC50 study the Mallard with
Boric Acid. Final Report.  Prokect No. 176-103.  Prepared by
Wildlife International, St. Michaels, MD.  Submitted to Kerr McGee
Chemical Corporation.  Oklahoma City, Ok.  EPA Accession Number
254367.

U.S. EPA (1982) Fish  Toxicity Laboratory Report Static Test No.
2571.  (Unpublished report concerning the toxicity of Boric Acid,
93.9%  on rainbow trout; prepared by the Chemical and Biological
Investigations Branch, ARC, Beltsville, MD.

U.S. EPA (1982)  Aquatic Invertebrates laboratory  Report. Static Test
No. 2750.  (Unpublished report on Daphnia mama; prepared by the
Chemical and Biological Investigations Branch, ARC, Beltsville, MD.

U.S. Borax Corporation.  Toxicology 20 Mule Team Boric Acid.  Vol
I. (Compilation: unpublished study received March 5,  1981 under
1623-117; CDI/244539).

U.S. Borax Corporation.  Toxicology 20 Mule Team Boric Acid.  Vol.
n (Compilation: unpublished study received March 5,  1981 under
1624-117; CDL: 244540).

U.S. Borax Corporation.  Toxicology 20 Mule Team Boric Acid.  Vol.
HI. (Compilation: unpublished study received March 5, 1981  under
 1624-117; CDL: 244541).

U.S. Borax Corporation.  Toxicology 20 Mule Team Boric Acid.  Vol.
IV.  (Compilation: unpublised study received March 5, 1981  under
 1624-117; CDL: 244542).

-------
             APPENDIX D




List, of Available Related Documents

-------

-------
       The following is a list of available documents related to Boric Acid and its Sodium
Salts.  It's puipose is to provide a path to more detailed information if it is needed.  These
accompanying documents are part of the Administrative Record for Boric Acid and its
Sodium Salts and are included in the EPA's Office of Pesticide Programs Public Docket,

       1.     Health and Environmental Effects Science Chapters

       2.     Detailed Label Usage Information System (LUIS) Report

       3.     Boric Acid and its  Sodium Salts RED Fact Sheet

       4.     PR Notice 91-2 (included in this appendix) pertains to the Label Ingredient
             Statement

       5.     Guidance for the Reregistration of Pesticide Products Containing Boric Acid
             and Boron Containing  Salts as the Active Ingredient.  Issued November 1985.
             (NTIS publication Number PB87-101903).

       6.     Guidance for the Registration and Reregistration of End-Use Pesticide Products
             Containing the Insecticidal Uses of Boric Acid - General Registration
             Standard.  Issued November  1985.

-------

-------
               UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

                             WASHINGTON, D.C. 20460
                                                             of
                                                     PREVENTION, PESTICIDES
                                                     AMD TOXIC WBSTANCES
                          PR NOTICE 91-2

         NOTICE TO MANUFACTURERS, PRODUCERS, FORMULATORS,
                  AND REGISTRANTS OF PESTICIDES

ATTENTION:  Persons Responsible for  Federal  Registration of
Pesticide Products.

SUBJECT: Accuracy of Stated Percentages  for Ingredients
Statement

I. PURPOSE:

     The purpose of this notice  is  to clarify the  Office  of
Pesticide Program's policy with  respect  to  the statement  of
percentages in a pesticide's label's ingredient statement.
Specifically, the amount  (percent by weight) of ingredient(s)
specified in the ingredient statement on the label must be statfed
as the nominal concentration of  such ingredient (s), as  that term
is defined in 40 CFR 158.153 (i). Accordingly, the  Agency  has
established the nominal concentration as the only  acceptable
label claim for the amount of active ingredient in the  product.

II. BACKGROUND

     For some time the Agency has accepted  two different  methods
of identifying on the label what percentage is claimed  for the
ingredient(s) contained in a pesticide.  Some applicants claimed  a
percentage which represented a level  between the upper  and the
lower certified limits. This was referred to as the nominal
concentration, other applicants  claimed  the lower  limit as the
percentage of the ingredient(s) that  would  be expected  to be
present in their product at the end  of the  product's shelf-life.
Unfcrtusitsly, this led to a great deal  of  confusion among the
regulated industry, the regulators, and  the consumers as  to
exactly how much of a given ingredient was  in a given product.
The Agency has established the nominal concentration as the only
acceptable label claim for the amount of active ingredient in the
product.

     Current regulations require that the percentage listed in
the active ingredient statement be ae precise as possible

-------
reflecting good manufacturing practices 40 CFR 156.10(g)(5).  The
certified limits required for each active ingredient are intended
to encompass any such "good manufacturing practice" variations 40
CFR 158.175(c)(3).                                         ^ J
The upper and lower certified limits, which must be proposed in
connection with a product's registration, represent the amounts
of an ingredient that may legally be present 40 CFR 158.175.  The
lower certified limit is used as the enforceable lower limit for
the product composition according to FIPRA section 12(a)(1)(C),
while the nominal concentration appearing on the label would be
the routinely achieved concentration used for calculation of
dosages and dilutions.

     The nominal concentration would in fact state the greatest
degree of accuracy that is warranted with respect to actual
product composition because the nominal concentration would be
the amount of active ingredient typically found in the product.

     It is important for registrants to note that certified
limits for active ingredients are not considered to be trade
secret information under FIFRA section 10(b). In this respect the
certified limits will be routinely provided by EPA to States  for
enforcement purposes, since the nominal concentration appearing
on the label may not represent the enforceable composition for
purposes of section 12(a)(1)(C).

III. REQUIREMENTS

     As described below under Unit V.  • COMPLIANCE SCHEDULE," all
currently registered products as well as all applications  for new
registration must comply with this Notice by specifying the
nominal concentration expressed as a percentage by weight  as  the
label claim in  the ingredient(s) statement and equivalence
statements if applicable  (e.g., elemental arsenic, metallic  zinc,
salt of an acid). In addition, the requirement for performing
sample analyses of five or more representative samples must  be
fulfilled. Copies of the  raw analytical  data must  be submitted
with the nominal ingredient  label claim.  Further information
about the analysis requirement may be  found in the 40 CFR
158.170. All  products  are required to  provide certified limits
for each active,  inert ingredient, impurities of toxicological
significance (i.e., upper  limit (s) only)  and on a case by case
basis as specified by EPA. These limits  are to be  set b»»»d on
xepxeattuuttive  sampling and chemical analysis {i. e. ,  quality
control) of the product.

     The format of  the ingredient  statement must conform to 40
CFR 156-Labeling Requirements For Pesticides  and Devices.
      After July 1, 1997, mil p«tioid« Ingredient Statements must
 be changed to nominal concentration.

-------
TV. PRODUCTS THAT REQUIRE EFFICACY DATA

     All pesticides are required to be efficacious. Therefore,
the certified lower limits may not be lower then the minimum
level to achieve efficacy. This is extremely important for
products which are intended to control pests which threaten the
public health, e.g., certain antimicrobial and rodenticide
products. Refer to 40 CFR 153.640.

     In those cases where efficacy limits have been established,
the Agency will not accept certified lower limits which are below
that level for the shelf life of the product.

V. COMPLIANCE SCHEDULE

     As described earlier, the purpose of this Notice is to make
the registration process more uniform and more manageable for
both the agency and the regulated community. It is the Agency's
intention to implement the requirements of this notice as>
smoothly as possible so as not to disrupt or delay the Agency's
high priority programs, i.e., reregistration, new chemical, or
fast track (FIFRA section 3(c)(3)(B). Therefore,
applicants/registrants are expected to comply with the
requirements of this Notice as follows:

     (1)  Beginning July l, 1991, all new product registrations
          submitted to the Agency are to comply with the
          requirements of this Notice.

     (2)  Registrants having products subject to reregistration
          under FIFRA section 4(a)  are to comply with the
          requirements of this Notice when specific products are
          called in by the Agency under Phase V of the
          Reregistration Program.

     (3)  All other products/applications that are not subject to
          (l) and (2) above will have until July 1, 1997, to
          comply with this Notice.  Such applications should note
          •Conversion to Nominal Concentrations on the
          application form. These types Or amendments will not be
          handled as "Fast Track" applications but will be
          handled as routine requests.

VI. FOR FURTHER INFORMATION

Contact Tyrone Aiken for information or questions concerning
this notice on (703) 308-7031.
                                             >    /* -
                                            e-cZZ,^
                                 Anna B. tXodcty, Dir»Ctor
                                 Registration Diviaicn (H-75OS

-------

-------
                   APPENDIX E




Generic and Product Specific Data Call-In Notice

-------

-------
            UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                       WASHINGTON, D.C. 20460

                   GENERIC AND PRODUCT SPECIFIC
                       DATA CALL-IN NOTICE          p^g  j g [994
CERTIFIED MAIL
                                                      OFFICE OF
                                                   PESTICIDES AND TOXIC
                                                     SUBSTANCES
Dear Sir or Madam:

     This Notice requires  you  and other registrants of pesticide
products containing the  active ingredient identified in
Attachment A of this Noticer the  Data Call-in Chemical Status
Sheet/ to submit certain data  as  noted herein to the U.S.
Environmental Protection Agency (EPA,  the Agency).  These data are
necessary to maintain the  continued registration of your
product(s) containing this active ingredient. Within 90 days
after you receive this Notice  you must respond as set forth in
Section III below. Your  response  must state:

     1.   How you will comply  with the requirements set forth in
          this Notice and  its  Attachments 1 through 7; or

     2.   Why you believe  you  are exempt from the requirements
          listed in this Notice and in Attachment 3 (for both
          generic and product  specific data), the Requirement s
          Status and Registrant's Response Form, (see section
          III-B); or

     3.   Why you believe  EPA  should not require your submission
          of data in the manner specified by this Notice  (see
          section III-D).

     If you do not respond to  this Notice, or if you do not
satisfy EPA that you will  comply with its requirements or should
be exempt or excused from  doing so, then the registration of your
product(s) subject to this Notice will be subject to suspension.
We have provided a list  of all of your products subject to this
Notice  in Attachment 2.  All products are listed on both the
generic and product specific Data Call-in Response Forms.   Also
included  is a list of all  registrants who were sent this Notice
 (Attachment 6).

     The  authority for this Notice is section 3(c)(2)(B) of the
Federal Insecticide, Fungicide and Rodenticide Act as amended
 (FIFRA),  7 U.S.C, section  136a(c) (2) (B) . Collection of this
information is authorized  under the Paperwork Reduction Act by
OMB Approval No. 2070-0107 and 2070-0057  (expiration date
3-31-96).
                                                        Printed on Recycled Paper

-------
     This Notice is divided into six sections and seven
Attachments. The Notice itself contains information and
instructions applicable to all Data Call-in Notices. The
Attachments contain specific chemical information and
instructions. The six sections of the Notice are:

Section I      -    Why You are Receiving this Notice
Section II     -    Data Required by this Notice
Section III    -    Compliance with Requirements of this Notice
Section IV     -    Consequences of Failure to Comply with this
                    Notice
Section V      -    Registrants' Obligation to Report Possible
                    Unreasonable Adverse Effects
Section VI     -    Inquiries and Responses to this Notice

     The Attachments to this Notice are:

     1 -  Data Call-in Chemical Status Sheet
     2 -  Generic Data Call-in and Product Specific Data
               Call-in Response Forms with Instructions
     3 -  Generic Data Call-in and Product Specific Data
               Call-in Requirements Status and Registrant's
                    Response Forms with Instructions
     4 -  EPA Grouping of End-Use Products for Meeting Acute
               Toxicology Data Requirements for Rereqistration

     6 -  List of Registrants Receiving This Notice
     7 -  Cost Share and Data Compensation Forms


SECTION I.  HHY YOU ARE RECEIVING THIS NOTICE

     The Agency has reviewed existing data for this active
ingredient(s) and reevaluated the data needed to support
continued registration of the subject active ingredient(s). This
revaluation identified additional data necessary to  assess the
health and  safety of the continued use of products  containing
this active ingredient(s). You have been sent this  Notice because
you have product(s) containing the subject active ingredients.


SECTION II. DATA REQUIRED BY THIS NOTICE

II-A. DATA  REQUIRED

     The data required by this Notice  are  specified in the
Requirements  Status and Registrant's Response Forms:  Attachment  3
 (for both generic  and  product  specific data  retirements) ,
Depending on the  results  of the  studies required in this Notice,
additional  studies/testing may be required.

-------
 II-B.  SCHEDULE FOR SUBMISSION OF  DATA

     You are  required to  submit the  data or  otherwise  satisfy the
 data requirements  specified  in the Requirements  Status and
 Registrant's  Response Forms  {Attachment  3} within  the  timeframes
 provided.

 II-C.  TESTING PROTOCOL

     All studies required under this Notice  must be  conducted in
 accordance with test standards outlined  in the Pesticide
 Assessment Guidelines for those studies  for  which  guidelines have
 been established.

     These EPA Guidelines are available  from the National
 Technical Information Service (NTIS), Attn:  Order  Desk, 5285 Port
 Royal  Road, Springfield,  Va  22161  (Telephone number:
 703-487-4650) .

     Protocols approved by the Organization  for  Economic
 Cooperation and Development  (OECD) are also  acceptable if the
 OECD recommended test standards conform  to those specified in the
 Pesticide Data Requirements  regulation  (40 CFR § 158.70). When
 using  the OECD protocols, they should be modified  as appropriate
 so that the data generated by the study  will satisfy the
 requirements  of 40  CFR §  158.  Normally,  the  Agency will not
 extend deadlines for complying with  data requirements  when the
 studies were  not conducted in accordance with acceptable
 standards. The OECD protocols are available  from OECD,  2001 L
 Street, N.W., Washington, D.C. 20036 (Telephone  number 202-785-
 6323?  Fax telephone number 202-785-0350).

     All new  studies and  proposed protocols  submitted  in response
to this Data  Call-in Notice must be  in accordance  with Good
Laboratory Practices [40  CFR Part 160].

 II-D-     REGISTRANTS RECEIVING PREVIOUS SECTION 3(C)(21(Bl
          NOTICES ISSUED  BY  THE AGENCY

     Unless otherwise noted herein,  this Data Call-In  does not in
any way supersede or change the requirements of  any previous Data
Call-in la) , or any  other  agreements  entered  into with  the Agency
pertaining to such prior  Notice. Registrants must  comply with the
requirements  of all Notices to avoid issuance of a Notice of
 Intent to Suspend their affected products.


SECTION III. COMPLIANCE WITH  REQUIREMENTS OF THIS  NOTICE

     You must use the correct  forms  and  instructions when
completing your response to this Notice.  The type of  Data
Call-in you must comply with  (Generic or Product Specific) is

-------
specified in item number 3 on the four Data Call-in forms
(Attachments 2 and 3) .

III-A. SCHEDULE FOR RESPONDING TO THE AGENCY

     The appropriate responses initially required by this Notice
for generic and product specific data must be submitted to the
Agency within 90 days after your receipt of this Notice. Failure
to adequately respond to this Notice within 90 days of your
receipt will be a basis for issuing a Notice of Intent to Suspend
(NOIS) affecting your products. This and other bases for issuance
of NOIS due to failure to comply with this Notice are presented
in Section IV-A and IV-B,

III-B. OPTIONS FOR RESPONDING TO THE AGENCY

     1 . Generic Data Requirements

     The options for responding to this Notice for generic data
requirements are:  (a) voluntary cancellation,. (b) delete use{s),
(c) claim generic data exemption, 
-------
      a.   Voluntary  Cancellation  -

      You may  avoid the  requirements of this Notice by  requesting
voluntary cancellation  of your product(s) containing the  active
ingredient that  is the  subject of this Notice.  If you  wish to
voluntarily cancel your product,  you must submit completed
Generic and Product  Specific Data Call-In Response Forms
 (Attachment 2),  indicating your election of this option.
Voluntary cancellation  is item number 5 on both Data Call-In
Response FormjsJ_. If you choose this option, these are the only
forms that you are required to complete.

      If you chose to voluntarily  cancel your product,  further
sale  and distribution of your product after the effective date of
cancellation  must be in accordance with the Existing Stocks
provisions of this Noticer which  are contained  in Section IV-C.

     b.   Use Deletion  -

     You may  avoid the  requirements of this Notice by  eliminating
the uses of your product to which the requirements apply. If you
wish to amend your registration to delete uses, you must submit
the Requirements Status and Registrant's Response Form
(Attachment 3), a completed application for amendment, a copy of
your proposed amended labeling, and all other information
required for  processing the application.  Use deletion is option
number 7 under item  9 in the instructions for the Requirements
Status and Registrant's Response  Forms. You must also  complete a
Data Call-In  Response Form by signing the certification, item
number 8.  Application  forms for  amending registrations may be
obtained from the Registration Support Branch,  Registration
Division, Office of  Pesticide Programs, EPA, by calling  (703)
308-8358.

     If you choose to delete the  use{s) subject to this Notice or
uses subject  to specific data requirements,  further sale,
distribution, or use of your product after one  year from the due
date of your  90 day  response, is  allowed only if the product
bears an amended label.

     c.   Generic Data Exemption  -

     Under section 3(c)(2)(D) of  FIFRA, an applicant for
registration  of a product is exempt from the requirement to
submit or cite generic data concerning an active ingredient if
the active ingredient in the product is derived exclusively from
purchased, registered pesticide products containing the active
ingredient. EPA has  concluded,  as an exercise of its discretion,
that it normally will not suspend the registration of  a product
which would qualify  and continue to qualify for the generic data

-------
exemption in section 3(c) <2)(D) of FIFRA. To qualify, all of the
following requirements must be met:

     (i).  The active ingredient in your registered product must
     be present solely because of incorporation of another
     registered product which contains the subject active
     ingredient and is purchased from a source not connected with
     your-

     {ii) .   Every registrant who is the ultimate source of the
     active ingredient in your product subject to this DCI must
     be in compliance with the requirements of this Notice and
     must remain in compliance; and

     (iii).  You must have provided to EPA an accurate and
     current "Confidential Statement of Formula" for each of your
     products to which this Notice applies.

     To apply for the Generic Data Exemption you must submit a
completed Data Call-in Response Form, Attachment 2 and all
supporting documentation. The Generic Data Exemption is item
number 6a on the Data Call-in Response Form. If you claim a
generic data exemption you are not required to complete the
Requirements Status and Registrant's Response Form. Generic Data
Exemption cannot be selected as an option for responding to
product specific data requirements.

     If you are granted a Generic Data Exemptionr you rely on the
efforts of other persons to provide the Agency with the required
data. If the registrant(s) who have committed to generate and
submit the required data fail to take appropriate steps to meet
requirements or are no longer in compliance with this Data Call-
in Notice,  the Agency will consider that both they and you are
not in compliance and will normally initiate proceedings to
suspend the registrations of both your and their product(s)r
unless you commit to submit and do submit the required data
within the specified time. In such cases the Agency generally
will not grant a time extension for submitting the data.

     d.   Satisfying the Generic Data Requirements of this Notice

     There are various options available to satisfy the generic
data requirements of this Notice. These options are discussed in
Section III-C.l. of this Notice and comprise options 1 through 6
of item 9 in the instructions for the Requirements Status and
Registrant's Response Form and item  6b on the Data Call-In
Response Form.  If you choose item 6b  (agree to satisfy the
generic data requirements), you must submit the Data Call-in
Response^ Form and the Requirements Status and Registrant' s
Response Form as well as any other information/data pertaining to
the option chosen to address the data requirement.  Your response
must be on the forms marked "GENERIC" in item number 3.

-------
     e.   Request  for Generic Data  Waivers.

     Waivers  for generic  data are discussed  in  Section  III-D.1.
of this Notice and are  covered by options  8  and 9  of  item  9  in
the instructions for the  Requirements  Status and Registrant's
Response Form. If  you choose one of these  options, you  must
submit both forms  as well as any other information/data
pertaining to the  option  chosen to  address the  data requirement.

     2. Product Specific  Data Requirements

     The options for responding to  this Notice  for product
specific data are:  (a) voluntary cancellation,  (b) agree to
satisfy the product specific data requirements  imposed  by this
Notice or  (c) request a data waiver(s).

     A discussion  of how  to respond if you choose  the Voluntary
Cancellation option is presented below.  A discussion of the
various options available for satisfying the product specific
data requirements  of this Notice is contained in Section III-C.2.
A discussion of options relating to requests for data waivers is
contained in Section III-D.2.

     Two forms apply to the product specific data  requirements
one or both of which must be used in responding to the  Agency,
depending upon your response.  These forms are  the Data-Call-in
Response Form, and the Requirements Status and  Registrantfs
Response Form, for product specific data {contained in
Attachments 2 and  3, respectively).  The Data Call-in Response
Form must be submitted as part of every response to this Notice.
In addition, one copy of  the Requirements  Status and Registrant's
Response Form also must be submitted for each product listed on
the Data Call-in Response Form unless  the  voluntary cancellation
option is selected.  Please note that  the  company's authorized
representative is  required to sign  the first page  of the Data
Call-In Response Form and Requirements Status and  Registrant's
Response Form (if  this form is required) and initial any
subsequent pages.  The forms contain separate detailed
instructions on the response options.  Do  not alter the printed
material. If you have questions or  need assistance in preparing-
your response, call or write the contact person(s) identified in
Attachment 1.

     a.   Voluntary Cancellation

     You may avoid the requirements  of this  Notice by requesting
voluntary cancellation of your product 
-------
Product Specific Data Call-in Response Forms. If you choose this
option, you must complete both Data Call-in response forms.
These are the only forms that you are required to complete.

     If you choose to voluntarily cancel your productr further
sale and distribution of your product after the effective date of
cancellation must be in accordance with the Existing Stocks
provisions of this Notice which are contained in Section IV-C.

     b.   Satisfying the Product Specific Data Requirements of
          this Notice.

     There are various options available to satisfy the product
specific data requirements of this Notice. These options are
discussed in Section III-C.2. of this Notice and comprise options
1 through 6 of item 9 in the instructions for the product
specific Requirements Status and Registrant's Response Form and
item numbers 7a and 7b (agree to satisfy the product specific
data requirements for an MUE or EUP as applicable) on the product
specific Data Call-in Response Form. Note that the options
available for addressing product specific data requirements
differ slightly from those options for fulfilling generic data
requirements. Deletion of a use{s) and the low volume/minor use
option are not valid options for fulfilling product specific data
requirements. It is important to ensure that you are using the
correct forms and instructions when completing your response to
the Reregistration Eligibility Decision document.

     c.   Request for Product Specific Data Waivers.

     Waivers for product specific data are discussed in Section
III-D.2. of this Notice and are covered by option 7 of item 9 in
the instructions for the Requirements Status and Registrant's
Response Form.  If you choose this option, you must submit the
Data Call-In Response Form and the Requirements Status and
Registrant's Response Form as well as any other information/data
pertaining to the option chosen to address the data requirement.
Your response must be on the forms marked "PRODUCT SPECIFIC" in
item number 3.

III-C SATISFYING THE DATA REQUIREMENTS OF THIS NOTICE

     1.   Generic Data

     If you acknowledge on the Generic Data__Call-In Response Form
that you agree to satisfy the generic data requirements  (i.e. you
select item number 6t>) , tlien you must select one of the six
options on the Generic Requirements Status and Registrant's
Response Form related to data production for each data
requirement. Your option selection should be entered under item
number 9, "Registrant Response." The six options related to data
production are the first six options discussed under item  9 in

                                8

-------
the instructions for completing the Requirements Status and
Registrant's Response Form. These six options are listed
immediately below with information in parentheses to guide you to
additional instructions provided in this Section. The options
are:

      (1)  I will generate and submit data within the specified
          timeframe  (Developing Data)
      (2)  I have entered into an agreement with one or more
          registrants to develop data jointly  (Cost Sharing)

      (3)  I have made offers to cost-share  (Offers to Cost Share)
      (4)  I am submitting an existing study that has not been
          submitted previously to the Agency by anyone
          (Submitting an Existing Study)
      (5)  I am submitting or citing data to upgrade a study
          classified by EPA as partially acceptable and
          upgradeable  (Upgrading a Study)
      (6)  I am citing an existing study that EPA has classified
          as acceptable or an existing study that has been
          submitted but not reviewed by the Agency  (Citing an
          Existing Study)

Option 1. Developing Data

     If you choose to develop the required data it must be in
conformance with Agency deadlines and with other Agency
requirements as referenced herein and in the attachments. All
data generated and submitted must comply with the Good Laboratory
Practice  (GLP) rule  (40 CFR Part 160), be conducted according to
the Pesticide Assessment Guidelines  (PAG) and be in conformance
with the requirements of PR Notice 86-5. In addition, certain
studies require Agency approval of test protocols in advance of
study initiation. Those studies for which a protocol must be
submitted have been identified in the Requirements Status and
Registrant's Response Form and/or footnotes to the form. If you
wish to use a protocol which differs from the options discussed
in Section II-C of this Notice, you must submit a detailed
description of the proposed protocol anct your reason for wishing
to use it. The Agency may choose to reject a protocol not
specified in Section ll-c. If the Agency rejects your protocol
you will be notified in writing, however, you should be aware
that rejection of a proposed protocol will not be a basis for
extending the deadline for submission of data.

     A progress report must be submitted for each study within 90
days from the date you are required to commit to generate or
undertake some other means to address that study requirement,
such as making an offer to cost share or agreeing to share in the
cost of developing that study.  This 90-day progress report must
include the date the study was or will be initiated and, for

-------
studies to be started within 12 months of commitment, the name
and address of the laboratory(ies) or individuals who are or will
be conducting the study.

     In addition, if the time frame for submission of a final
report is more than 1 year, interim reports must be submitted at
12 month intervals from the date you are required to commit to
generate or otherwise address the requirement for the study. In
addition to the other information specified in the preceding
paragraph, at a minimum, a brief description of current activity
on and the status of the study must be included as well as a full
description of any problems encountered since the last progress
report.

     The time frames in the Requirements Status and Reciistrant' s
Response Form are the time frames that the Agency is allowing for
the submission of completed study reports or protocols. The noted
deadlines run from the date of the receipt of this Notice by the
registrant. If the data are not submitted by the deadline, each
registrant is subject to receipt of a Notice of Intent to Suspend
the affected registration
-------
final arrangement between the parties or the mechanism to resolve
the terms. Section 3 (c)(2)(B) provides that if the parties cannot
resolve the terms of the agreement they may resolve their
differences through binding arbitration.

Option 3. Offer to Share in the Cost of Data Development

     If you have made an offer to pay in an attempt to enter into
an agreement or amend an existing agreement to meet the
requirements of this Notice and have been unsuccessful, you may
request EPA {by selecting this option) to exercise its discretion
not to suspend your registration(s), although you do not comply
with the data submission requirements of this Notice. EPA has
determined that as a general policy, absent other relevant
considerations, it will not suspend the registration of a product
of a registrant who has in good faith sought and continues to
seek to enter into a joint data development/cost sharing program,
but the other registrant(s)  developing the data has refused to
accept the offer. To qualify for this option, you must submit
documentation to the Agency proving that you have made an offer
to another registrant  (who has an obligation to submit data) to
share in the burden of developing that data. You must also submit
to the Agency a completed EPA Form 8570-32, Certification of
Offer to Cost Share in the Development of Data, Attachment 7.  In
addition, you must demonstrate that the other registrant to whom
the offer was made has not accepted your offer to enter into a
cost-sharing agreement by including a copy of your offer and
proof of the other registrant's receipt of that offer  (such as a
certified mail receipt). Your offer must, in addition to anything
else, offer to share in the burden of producing the data upon
terms to be agreed to or,  failing agreement, to be bound by
binding arbitration as provided by FIFRA section 3(c)(2)(B)(iii)
and must not qualify this offer. The other registrant must also
inform EPA of its election of an option to develop and submit the
data required by this Notice by submitting a Data Call-in
Response Form and a Requirements Status and Registrant's Response
Form committing to develop and submit the data required by this
Notice.

     In order for you to avoid suspension under this option, you
may not withdraw your offer to share in the burden of developing
the data. In addition, the other registrant must fulfill its
commitment to develop and submit the data as required by this
Notice. If the other registrant fails to develop the data or for
some other reason is subject to suspension, your registration as
well as that of the other registrant normally will be subject to
initiation of suspension proceedings, unless you commit to
submit, and do submit, the required data in the specified time
frame. In such cases, the Agency generally will not grant a time
extension for submitting the data.
                                11

-------
Option 4. SnHinit-hJ.nQ an Existing Study

     If you choose to submit an existing study in response to
this Notice, you must determine that the study satisfies the
requirements imposed by this Notice. You may only submit a study
that has not been previously submitted to the Agency or
previously cited by anyone. Existing studies are studies which
predate issuance of this Notice. Do not use this option if you
are submitting data to upgrade a study.  (See Option 5}.

     You should be aware that if the Agency determines that the
study is not acceptable, the Agency will require you to comply
with this Notice, normally without an extension of the required
date of submission. The Agency may determine at any time that a
study is not valid and needs to be repeated.

     To meet the requirements of the DCI Notice for submitting an
existing study, all of the following three criteria must be
clearly met;

     a.   You must certify at the time that the existing study is
          submitted that the raw data and specimens from the
          study are available for audit  and review and you must
          identify where they are available. This must be done in
          accordance with the requirements of the Good Laboratory
          Practice  (GLP) regulation, 40  CFR Part 160. As stated
          in 40 CFR 160.3  "Mr] aw data'  means any laboratory
          worksheets, records, memoranda, notes, or exact copies
          thereof, that are the result of original observations
          and activities of a study and  are necessary for the
          reconstruction and evaluation  of the report of that
          study. In the event that exact transcripts of raw data
          have been prepared  
-------
     c.   You must certify that each study fulfills the
          acceptance criteria for the Guideline relevant to the
          study provided in the FIFRA Accelerated Reregistration
          Phase 3 Technical Guidance and that the study has been
          conducted according to the Pesticide Assessment
          Guidelines (FAG) or meets the purpose of the PAG (both
          available from NTIS) . A study not conducted according
          to the PAG may be submitted to the Agency for
          consideration if the registrant believes that the study
          clearly meets the purpose of the PAG. The registrant is
          referred to 40 CFR 158.70 which states the Agency's
          policy regarding acceptable protocols - If you wish to
          submit the study, you must, in addition to certifying
          that the purposes of the PAG are met by the study,
          clearly articulate the rationale why you believe the
          study meets the purpose of the PAG, including copies of
          any supporting information or data. It has been the
          Agency's experience that studies completed prior to
          January 1970 rarely satisfied the purpose of the PAG
          and that necessary raw data usually are not available
          for such studies.

     If you submit an existing study, you must certify that the
study meets all requirements of the criteria outlined above.

     If EPA has previously reviewed a protocol for a study you
are submitting, you must identify any action taken by the Agency
on the protocol and must indicate, as part of your certification,
the manner in which all Agency comments, concerns, or issues were
addressed in the final protocol and study.

     If you know of a study pertaining to any requirement in this
Notice which does not meet the criteria outlined above but does
contain factual information regarding unreasonable adverse
effects, you must notify the Agency of such a study. If such
study is in the Agency's files, you need only cite it along with
the notification. If not in the Agency's files, you must submit a
summary and copies as required by PR Notice 86-5.

       5 , Upcrradincr a Study
     If a study has been classified as partially acceptable and
upgradeable, you may submit data to upgrade that study. The
Agency will review the data submitted and determine if the
requirement is satisfied. If the Agency decides the requirement
is not satisfied, you may still be required to submit new data
normally without any time extension. Deficient, but upgradeable
studies will normally be classified as supplemental. However, it
is important to note that not all studies classified as
supplemental are upgradeable . If you have questions regarding the
classification of a study or whether a study may be upgraded,
call or write the contact person listed in Attachment 1 . If you

                                13

-------
submit data to upgrade an existing study you must satisfy or
supply information to correct all deficiencies in the study
identified by EPA. You must provide a clearly articulated
rationale of how the deficiencies have been remedied or corrected
and why the study should be rated as acceptable to EPA. Your
submission must also specify the MRID number(s) of the study
which you are attempting to upgrade and must be in conformance
with PR Notice 86-5.

     Do not submit additional data for the purpose of upgrading a
study classified as unacceptable and determined by the Agency as
not capable of being upgraded.

     This option also should be used to cite data that has been
previously submitted to upgrade a study, but has not yet been
reviewed by the Agency. You must provide the MRID number of the
data submission as well as the MRID number of the study being
upgraded.

     The criteria for submitting an existing study, as specified
in Option 4 above, apply to all data submissions intended to
upgrade studies. Additionally, your submission of data intended
to upgrade studies must be accompanied by a certification that
you comply with each of those criteria, as well as a
certification regarding protocol compliance with Agency
requirements.

Option 6. Citing Existing Studies

     If you choose to cite a study that has been previously
submitted to EPA, that study must have been previously classified
by EPA as acceptable, or it must be a study which has not yet
been reviewed by the Agency. Acceptable toxicology studies
generally will have been classified as "core-guideline" or "core-
minimum."  For ecological effects studies, the classification
generally would be a rating of "core." For all other disciplines
the classification would be "acceptable." With respect to any
studies for which you wish to select this option, you must
provide the MRID number of the study you are citing and, if the
study has been reviewed by the Agency, you must provide the
Agency's classification of the study.

     If you are citing a study of which you are not the original
data submitter, you must submit a completed copy of EPA Form
8570-31/ Certification with Respect to Data Compensation
Requi rements.

     2. Product Specific Data

     If you acknowledge on the product specific Data Call-in
Response Form that you agree to satisfy the product specific data
requirements  (i.e. you select option 7a or 7b), then you must

                                14

-------
select one of the six options on the Requirements Status and
Registrant^ Response Form related to data production for each
data requirement. Your option selection should be entered under
item number 9, "Registrant Response." The six options related to
data production are the first six options discussed under item 9
in the instructions for completing the Requirements Status, and
Registrant's Response Form. These six options are listed
immediately below with information in parentheses to guide
registrants to additional instructions provided in this Section,
The options are:

      (1)  I will generate and submit data within the specified
          time-frame  (Developing Data)
      (2)  I have entered into an agreement with one or more
          registrants to develop data jointly (Cost Sharing)
      (3)  I have made offers to cost-share  (Offers to Cost Share)
      (4)  I am submitting an existing study that has not been
          submitted previously to the Agency by anyone
           (Submitting an Existing Study)
      (5)  I am submitting or citing data to upgrade a study
          classified by EPA as partially acceptable and
          upgradeable  (Upgrading a Study)

      (6)  I am citing an existing study that EPA has classified
          as acceptable or an existing study that has been
          submitted but not reviewed by the Agency  (Citing an
          Existing Study)

Option 1. Developing Data — The requirements for developing
product specific data are the same as those described for generic
data  (see Section III.C.I, Option 1) except that normally no
protocols or progress reports are required.

Option 2. Agree to Share in Cost to Dgyelop Data -- If you enter
into an agreement to cost share, the same requirements apply to
product specific data as to generic data  (see Section III.C.I,
Option 2}. However, registrants may only choose this option for
acute toxicity data and certain efficacy data and only if EPA has
indicated in the attached data tables that your product and at
least one other product are similar for purposes of depending on
the same data. If this is the case, data may be generated for
just one of the products in the group. The registration number of
the product for which data will be submitted must be noted in the
agreement to cost share by the registrant selecting this option.

Option 3. Offer to Share in the Cost of Data Development —The
same requirements for generic data  (Section III.C.I., Option 3)
apply to this option. This option only applies to acute toxicity
and certain efficacy data as described in option 2  above.
                                15

-------
Option 4.Submitting an Existing Study — The same requirements
described for generic data  (see Section III.C.I.f Option 4) apply
to this option for product specific data.

Option 5. Upgrading a Study -- The same requirements described
for generic data  {see Section lll.C.l., Option 5) apply to this
option for product specific data.

Option 6. Citing Existing Studies -- The same requirements
described for generic data  (see Section III.C.I., Option 6) apply
to this option for product specific data.

     Registrants who select one of the above 6 options must meet
all of the requirements described in the instructions for
completing the Data Call-In Response^ Form and the Requ i rements
Status and Registrant's Response Form, and in the generic data
requirements section (III.C.l.), as appropriate.

III-D REQUESTS FOR DATA WAIVERS

     1.   Generic Data

     There are two types of data waiver responses to this Notice,
The first is a request for a low volume/minor use waiver and the
second is a waiver request based on your belief that the data
requirement(s) are not appropriate for your product.

     a.   Low Volume/Minor Use Waiver

          Option  8 under item 9 on the Requirement3 Status and
     Registrant'a Response Form. Section 3(c)(2)(A) of FIFRA
     requires EPA to consider the appropriateness of requiring
     data for low volume, minor use pesticides. In implementing
     this provision, EPA considers low volume pesticides to be
     only those active ingredients whose total production volume
     for all pesticide registrants is small. In determining
     whether to grant a low volume, minor use waiver, the Agency
     will consider the extent, pattern and volume of use, the
     economic incentive to conduct the testing, the importance of
     the pesticide, and the exposure and risk firom use of the
     pesticide. If an active ingredient is used for both high
     volume and low volume uses, a low volume exemption will not
     be approved. If all uses of an active ingredient are low
     volume and the combined volumes for all uses are also low,
     then an exemption may be granted, depending on review of
     other information outlined below. An exemption will not be
     granted, if any registrant of the active ingredient elects to
     conduct the  testing. Any registrant receiving a low volume
     minor use waiver must  remain within the sales figures in
     their forecast supporting the waiver request in order to
     remain qualified for such waiver. If granted a waiver, a


                                16

-------
registrant will be required, as a condition of the waiver,
to submit annual sales reports. The Agency will respond to
requests for waivers in writing.

     To apply for a low volumer minor use waiver, you must
submit the following information, as applicable to your
product(s), as part of your 90-day response to this Notice:

     (i).  Total company sales  (pounds and dollars) of all
registered product(s) containing the active ingredient. If
applicable to the active ingredient, include foreign sales
for those products that are not registered in this country
but are applied to sugar (cane or beet), coffee, bananas,
cocoa,  and other such crops. Present the above information
by year for each of the past five years.

     
-------
     the active ingredient (following the parameters in item 3
     above),  and costs of data development pertaining to the
     active ingredient.

          (viii)   A description of the importance and unique
     benefits of the active ingredient to users. Discuss the use
     patterns and the effectiveness of the active ingredient
     relative to registered alternative chemicals and
     non-chemical control strategies. Focus on benefits unique to
     the active ingredientr providing information that is as
     quantitative as possible. If you do not have quantitative
     data upon which to base your estimates,, then present the
     reasoning used to derive your estimates. TO assist the
     Agency in determining the degree of importance of the active
     ingredient in terms of its benefits, you should provide
     information on any of the following factors, as applicable
     to your product(s):  (a)  documentation of the usefulness of
     the active ingredient in Integrated Pest Management, {b)
     description of the beneficial impacts on the environment of
     use of the active ingredient, as opposed to its registered
     alternatives,  (c) information on the breakdown of the active
     ingredient after use and on its persistence in the
     environment, and (d) description of its usefulness against a
     pest{s)  of public health significance.

     Failure to submit sufficient information for the Agency to
make a determination regarding a request for a low volume/minor
use waiver will result in denial of the request for a waiver.

     b.   Request for Waiver of Data

          Option 9, under Item 9, on the Requirements Status and
     Registrants Response Form. This option may be used if you
     believe that a particular data requirement should not apply
     because the requirement is inappropriate. You must submit a
     rationale explaining why you believe the data requirements
     should not apply. You also must submit the current label(s)
     of your product(s) and, if a current copy of your
     Confidential Statement of Formula is not already on file you
     must submit a current copy -

          You will be informed of the Agency's decision in
     writing. If the Agency determines that the data requirements
     of this Notice are not appropriate to your product(s), you
     will not be required to supply the data pursuant to section
     3{c) <2) (B) . If EPA determines that the data are required for
     your product (s) , you must choose a method of meeting the
     requirements of this Notice within the time frame provided
     by this Notice. Within 30 days of your receipt of the
     Agency's written decision, you must  submit  a revised
     Re cru i r ement g Status  and Registrant's Response Form
     indicating the option chosen,

                                18

-------
     2.  Product Specific Data

     If you request a waiver for product specific data because
you believe it is inappropriate, you must attach a complete
justification for the request including technical reasons, data
and references to relevant EPA regulations, guidelines or
policies.   (Note: any supplemental data must be submitted in the
format required by PR Notice 86-5). This will be the only
opportunity to state the reasons or provide information in
support of your request. If the Agency approves your waiver
request, you will not be required to supply the data pursuant to
section 3(c)(2)(B) of FIFRA. If the Agency denies your waiver
request, you must choose an option for meeting the data
requirements of this Notice within 30 days of the receipt of the
Agency's decision.  You must indicate and submit the option
chosen on the product specific Requirements Status and
Registrant's Response Form. Product specific data requirements
for product chemistry,, acute toxicity and efficacy (where
appropriate) are required for all products and the Agency would
grant a waiver only under extraordinary circumstances. You should
also be aware that submitting a waiver request will not
automatically extend the due date for the study in question.
Waiver requests submitted without adequate supporting rationale
will be denied and the original due date will remain in force.

SECTION IV.    CONSEQUENCES OF FAILURE TO COMPLY WITH THIS NOTICE

IV-A NOTICE OF INTENT TO SUSPEND

     The Agency may issue a Notice of Intent to Suspend products
subject to this Notice due to failure by a registrant to comply
with the requirements of this Data Call-in Notice, pursuant to

FIFRA section 3(c)(2)(B). Events which may be the basis for
issuance of a Notice of Intent to Suspend include, but are not
limited to, the following:

     1.   Failure to respond as required by this Notice within 90
          days of your receipt of this Notice.

     2.   Failure to submit on the required schedule an
           acceptable proposed or  final protocol when such is
           required to be submitted to the Agency for review.

     3.   Failure to submit on the required schedule an adequate
          progress report on a study as required by this Notice.

     4.   Failure to submit on the required schedule acceptable
           data as required by this Notice.

     5.   Failure to take a required action or submit adequate
           information pertaining  to any option chosen to address

                                19

-------
          the  data  requirements  (e.g.,  any  required action or
          information pertaining to  submission  or  citation of
          existing  studies  or  offers,  arrangements,  or
          arbitration on the sharing of costs or the formation of
          Task Forcesr  failure to  comply with the  terms of an
          agreement or  arbitration concerning joint data
          development or failure to  comply  with any terms  of a
          data waiver).

     6.    Failure to submit supportable certifications as  to the
          conditions of submitted  studies,  as required by  Section
          III-C of  this Notice.

     7.    Withdrawal of an  offer to  share in the cost of
          developing required  data.

     8.    Failure of the registrant  to whom you have tendered an
          offer to  share in the  cost of developing data and
          provided  proof of the  registrant's receipt of such
          offer or  failure  of  a  registrant  on whom you rely for a
          generic data  exemption either to:

          i.   Inform EPA of intent to develop and  submit the data
          required  by this  Notice  on a Data Call-in Response Form
          and a Requirements  Status  and Registrant7 s Response
          Form.

          ii.   Fulfill  the  commitment to develop  and submit the
          data as required  by this Notice;  or

          iii.  Otherwise take appropriate  steps to meet the
          requirements  stated in this Notice,

          unless you commit to submit and do submit the required
          data in the specified time frame.

     9.    Failure to take  any required or appropriate steps, not
          mentioned above,  at any  time following the issuance of
          this Notice.

IV-B.     BASIS FOR DETERMINATION  THAT SUBMITTED STUDY IS
          UHACCEP TABLE

     The Agency may determine that a study  (even if submitted
within the required time)  is  unacceptable and constitutes a basis
for issuance of a Notice of Intent to Suspend.  The grounds for
suspension includeT but are not limited to, failure to meet any
of the following:

     1)    EPA requirements specified in the Data Call-in Notice
     or other documents incorporated by reference  {including, as
     applicable, EPA Pesticide Assessment Guidelines, Data

                                20

-------
     Reporting Guidelines,  and GeneTox Health Effects Test
     Guidelines) regarding the design, conduct, and reporting of
     required studies. Such requirements include, but are not
     limited to, those relating to test material, test
     procedures, selection of species, number of animals, sex and
     distribution of animals, dose and effect levels to be tested
     or attained, duration of test, and, as applicable, Good
     Laboratory Practices.

     2)   EPA requirements regarding the submission of protocols,
     including the incorporation of any changes required by the
     Agency following review.

     3)   EPA requirements regarding the reporting of data,
     including the manner of reporting, the completeness of
     resultsr  and the adequacy of any required supporting  (or
     raw)  data, including,  but not limited to, requirements
     referenced or included in this Notice or contained in PR
     86-5. All studies must be submitted, in the form, of a final
     report; a preliminary report will not be considered to
     fulfill the submission requirement.

IV-C EXISTING STOCKS OF SUSPENDED OR CANCELLED PRODUCTS

     EPA has statutory authority to permit continued sale,
distribution and use of existing stocks of a pesticide product
which has been suspended or cancelled if doing so would be
consistent with the purposes of the Act.

     The Agency has determined that such disposition by
registrants of existing stocks for a suspended registration when
a section 3(c)(2)(B) data request is outstanding generally would
not be consistent with the Act's purposes. Accordingly, the
Agency anticipates granting registrants permission to sell,
distribute, or use existing stocks of suspended product(s) only
in exceptional circumstances, if you believe such disposition of
existing stocks of your product{s) which may be suspended for
failure to comply with this Notice should be permitted, you have
the burden of clearly demonstrating to EPA that granting such
permission would be consistent with the Act. You also must
explain why an "existing stocks" provision is necessary,
including a statement of the quantity of existing stocks and your
estimate of the time required for their sale, distribution, and
use. Unless you meet this burden, the Agency will not consider
any request pertaining to the continued sale, distribution, or
use of your existing stocks after suspension.

     If you request a voluntary cancellation of your product(s)
as a response to this Notice and your product is in full
compliance with all Agency requirements, you will have, under
most circumstances, one year from the date your 90 day response
to this Notice is due, to sell, distribute, or use existing

                                21

-------
stocks. Normally, the Agency will allow persons other than the
registrant such as independent distributors, retailers and end
users to sell, distribute or use such existing stocks until the
stocks are exhausted. Any sale, distribution or use of stocks of
voluntarily cancelled products containing an active ingredient
for which the Agency has particular risk concerns will be
determined on a case-by-case basis.

     Requests for voluntary cancellation received after the 90
day response period required by this Notice will not result in
the agency granting any additional time to sell, distribute, or
use existing stocks beyond a year from the date the 90 day
response was due, unless you demonstrate to the Agency that you
are in full compliance with all Agency requirements, including
the requirements of this Notice. For example, if you decide to
voluntarily cancel your registration six months before a 3-year
study is scheduled to be submitted, all progress reports and
other information necessary to establish that you have been
conducting the study in an acceptable and good faith manner must
have been submitted to the Agency, before EPA will consider
granting an existing stocks provision.



               UMRE&SONftBT.F: ADVERSE EFFECTS

     Registrants are reminded that FIFRA section 6(a)(2) states
that if at any time after a pesticide is registered a registrant
has additional factual information regarding unreasonable adverse
effects on the environment by the pesticide, the registrant shall
submit the information to the Agency. Registrants must notify the
Agency of any factual information they have, from whatever
source, including but not limited to interim or preliminary
results of studies, regarding unreasonable adverse effects on man
or the environment. This requirement continues as long as the
products are registered by the Agency.


SECTION VI_    INQUIRIES AND RESPONSES^ TO THIS NOTICE

     If you have any questions regarding the requirements and
procedures established by this Notice, call the contact person(s)
listed in Attachment 1, the Data Call-in Chemical Status Sheet.

     All responses to this Notice must include completed Data
Call-in Response Forms  (Attachment 2)and completed Requirements
Status and Registrant's Response Forms  (Attachment 3), for both
 (generic and product specific  data) and any other documents
required by this Notice, and should be submitted to the contact
person(s) identified in Attachment 1.  If the voluntary
cancellation  or  generic data exemption option is chosen, only the


                                22

-------
Generic and Product Specific Data Call-In Response Forms need be
submitted.

     The Office of Compliance Monitoring  (OCM) of the Office of
Prevention,. Pesticides and Toxic Substances  (OPPTS) , EPA, will be
monitoring the data being generated in response to this Notice.
                         Sincerely yours,
                         Daniel M, Barolo, Director
                         Special Review and
                           Reregistration Division
Att achment s
     The Attachments to this Notice are:

     1 -  Data Call-In Chemical Status Sheet
     2 -  Generic Data Call-in and Product Specific Data
               Call-in Response Forms with Instructions
     3 -  Generic Data Call-in and Product Specific Data
               Call~In Recpairements Status and Registrant's
                    Response Forms with Instructions
     •4 —  EPA Grouping of End—Use Products for Meeting Acute
               Toxicology Data Requirements for Reregistration
     5 -  EPA Acceptance Criteria
     6 -  List of Registrants Receiving This Notice
     7 -  Cost Share and Data Compensation Forms
                                23

-------

-------
                  Attachment 1



Generic and Product Specific Data Call-in Notice



       Data Call-In Chemical Status Sheet

-------

-------
            Generic and Product Specific Data Call-In

                      Chemical Status Sheet
                               for
                 Boric Acid and its Sodium Salts
INTRODUCTION

     You have been sent this combined Generic and Product
Specific Data Call-In Notice because you have product(s)
containing boric acid and its sodium salts; specifically this
Notice covers products containing boric acid, sodium tetraborate
decahydrate {borax decahydrate), sodium tetraborate pentahydrate
(borax pentahydrate),  sodium tetraborate  (anhydrous borax),
disodium octaborate tetrahydrate, disodium octaborate
(anhydrous),  and sodium metaborate.

     This combined Generic and Product Specific Data Call-In
Chemical Status Sheet contains an overview of data required by
this combined notice,  and points of contact for inquiries
pertaining to the reregistration of boric acid and its sodium
salts.  This attachment is to be used in conjunction with:

     •    The Combined Generic and Product Specific Data Call-In
          Notice (Appendix E),
     •    The Generic Data Call-In and Product Specific Data
          Call-In Response Forms with Instructions (Attachment 2)
     •    The Generic Data Call-In and Product Specific Data
          Call-In Requirements Status and Registrant's Response
          Forms with Instructions  (Attachments 3),
     •    EPA's Grouping of End-Use Products for Meeting Acute
          Toxicology Data Requirements for Reregistration
           (Attachment 4),
     •    The EPA Acceptance Criteria (Attachment 5) ,
     •    List of registrants receiving this combined DCI
           (Attachment 6), and
     •    The Cost Share and Data Compensation Forms
           (Attachment 7)

Instructions and guidance accompany each form.
DATA REQUIRED BY THIS NOTICE

     The additional data requirements needed to complete the data
base for Boric Acid and its Sodium Salts are contained in the
Requirements Status and Registrant' s R6spon.se Fontis.  (Attachment
3).   The Agency has concluded that additional data on Boric Acid
and its Sodium Salts are needed for specific products.  These
data are required to be submitted to the Agency within the time
frame listed.  These data are needed to fully complete the
reregistration of all eligible Boric Acid and its Sodium Salts
products.

-------
INQUIRIES AND RESPONSES TO THIS NOTICE

     If you have any questions regarding the generic database of
Boric Acid and its Sodium Salts, please contact Mario F. Fiol at
(703) 308-8049.

     If you have any questions regarding Che product specific
data requirements and procedures established by this Notice,
please contact Sue Rathman at  (703) 308-8049.

     All responses to this Notice for the product specific data
requirements should be submitted to:

     Bv P.S. Mail:

          Document Processing Desk  (RED-SRRD-PRB-0024)
          Office of Pesticide Programs (7504C)
          EPA, 401 M St. S.W.
          Washington, D.C. 20460-0001

     By express:

          Document Processing Desk  (RED-SRRD-PRB-0024)
          Office of Pesticide Programs (7504C)
          Room 266A, Crystal Mall 2
          1921 Jefferson Davis Hwy.
          Arlington, VA 22202

-------
                  Attachment 2



Generic and Product Specific Data Call-in Notice



          Data Call-in Response Forms



               With Instructions

-------

-------
                   Instructions  For Completing
                               The
                  "Data Call-in Response Forms"
        For The Generic And Product Specific Data Call-in
INTRODUCTION

     These instructions apply to the Generic and Product Specific
"Data Call-in Response Forms" and are to be used by registrants
to respond to generic and product specific Data Call-ins as part
of EPA' s Reregistration Program under the Federal Insecticide,
Fungicider and Rodenticide Act.  The type of data call-in
(generic or product specific) is indicated in item number 3
("Date and Type of DCI") on each form.  BOTH "Data Call-in
Response" forms must be completed.

     Although the form is the same for both generic and product
specific data, instructions for completing these forms are
different.  Please read these instructions carefully before
filling out the forms.

     EPA has developed these forms individually for each
registrant, and has preprinted these forms with a number of
items.  DO NOT use these forms for any other active ingredient.

     Items 1 through 4 have been preprinted on the form.  Items 5
through 7 must be completed by the registrant as appropriate.
Items 8 through 11 must be completed by the registrant before
submitting a response to the Agency,

     The public reporting burden for this collection of
information is estimated to average 15 minutes per response,
including time for reviewing instructions, searching existing
data sources, gathering and maintaining the data needed, and
completing and reviewing the collection of information. Send
comments regarding the burden estimate or any other aspect of
this collection of information, including suggestions for
reducing this burden, to Chief, Information Policy Branch, Mail
Code 2136, U.S. Environmental Protection Agency, 401 M St., S.W.,
Washington, D.C. 20460; and to the Office of Management and
Budget, Paperwork Reduction Project 2070-0107, Washington, D.C.
20503.

-------
INSTRUCTIONS FOR COMPLETING THE DATA CALL-IN RESPONSE FORMS
Generic and Product Specific Data Call-in
Item 1.   OH BOTH FORMS:  This item identifies your company name,
          number and address.

Item 2.   ON BOTH FORMS:  This item identifies the case number,
          case name, EPA. chemical number and chemical name.

Item 3.   ON BOTH FORMS:  This item identifies the type of Data
          Call-in.  The date of issuance is date stamped.

Item 4,   ON BOTH FORMS:  This item identifies the EPA product
          registrations relevant to the data call-in.  Please
          note that you are also responsible for informing the
          Agency of your response regarding any product that you
          believe may be covered by this Data Call-in but that is
          not listed by the Agency in Item 4. You must bring any
          such apparent omission to the Agency's attention within
          the period required for submission of this response
          form,

Item 5.   ON BOTH FORMS:  Check this item for each product
          registration you wish to cancel voluntarily. If a
          registration number is listed for a product for which
          you previously requested voluntary cancellation,
          indicate in Item 5 the date of that request. Since this
          Data Call-in requires both generic and product specific
          data, you must complete item 5 on both Data Call-in
          response forms.  You do not need to complete any item
          on the Requirements Status and Registrant's Response
          Forms.

Item 6a.  ON THE GENERIC DATA FORM: Check this Item if the Data
          Call-in is for generic data as indicated in Item 3 and
          you are eligible for a Generic Data Exemption for the
          chemical listed in Item 2 and used in the subject
          product.  By electing this exemption, you agree to the
          terms and. conditions of a Generic Data Exemption as
          explained in the Data Call-in Notice.

          If you are eligible for or claim a Generic Data
          Exemption, enter the EPA registration Number of each
          registered source of that active ingredient that you
          use in your product.

          Typically, if you purchase an EPA-registered product
          from one or more other producers  (who, with respect to
          the incorporated product, are in compliance with this
          and any other outstanding Data Call-in Notice) r and.

-------
INSTRUCTIONS FOR COMPLETING THE DATA CALL-IN RESPONSE FORMS
Generic and. Product Specific Data Call-In
          incorporate that product into all your products, you
          may complete this item for all products listed on this
          form. If, however, you produce the active ingredient
          yourself, or use any unregistered product (regardless
          of the fact that some of your sources are registered),
          you may not claim a Generic Data Exemption and you may
          not select this item.

Item 6b.  ON THE GENERIC DATA FORM:  Check this Item if the Data
          Call-in is for generic data as indicated in Item 3 and
          if you are agreeing to satisfy the generic data
          requirements of this Data Call-in. Attach the
          Requirements Status and Registrant' s Response Form that
          indicates how you will satisfy those requirements.

          NOTE:  Item 6a and 6b are not applicable for Product
          Specific Data.

Item 7a.  ON THE PRODUCT SPECIFIC DATA FORM:  For each
          manufacturing use product (MtTP)  for which you wish to
          maintain registration, you must agree to satisfy the
          data requirements by responding "yes."

Item 7b.  For each end use product (EUP) for which you wish to
          maintain registration, you must agree to satisfy the
          data requirements by responding "yes."

          FOR BOTH MUP and EUP products

          You should also respond "yes" to this item <7a for
          MUP's and 7b for EUP's)  if your product is identical to
          another product and you qualify for a data exemption.
          You must provide the EPA registration numbers of your
          source
-------
INSTRUCTIONS FOR COMPLETING THE DATA CALL-IN RESPONSE! FORMS
Generic and Product Specific Data Call-in
Item 8.   ON BOTH FORMS:  This certification statement must be
          signed by an authorized representative of your company
          and the person signing must include his/her title.
          Additional pages used in your response must be
          initialled and dated in the space provided for the
          certification.

Item 9.   ON BOTH FORMS:  Enter the date of signature.

Item 10.  ON BOTH FORMS:  Enter the name of the person EPA should
          contact with questions regarding your response.

Item 11.  ON BOTH FORMS:  Enter the phone number of your company
          contact.
Note:     You may provide additional information that does not
          fit on this form in a signed letter that accompanies
          your response.  For example, you may wish to report
          that your product has already been transferred to
          another company or that you have already voluntarily
          cancelled this product. For these cases, please supply
          all relevant details so that EPA can ensure that its
          records are correct.

-------
          Generic



Data Call-in Response Form

-------

-------
DRAFTCOPY
United States Environmental Protection Agency
Washington, D.C. 20460
DATA CALL-IN RESPONSE

Fon Approved
0KB Ho. 2070-0107
2070-0057
Approval Expire* 03-31-96
INSTRUCTIONS: Pl*a*e type or print In ittk. Bl«»e read carefully the attached inetcuotion* «nd supply the information requested on thi* fern.
1. Campaas nuw and Address 2- C«*e * and Nana
SAMPLE COMPANY 0024 Borin Ar.id & its Soditim Salts
NO STREET ADDRESS ch-1«l * -ad "—
NO CITY, XX 00000
4. EPA Product
R*gl*t»fcion
HNNNNN-NNNNN
5. I wiih -bo
oanotl tbi»
pcoduat r*gia-
tration volun-
tarily

«. G«n*rla Data
«a. I am alalBin? a G«n«ia
Data Ennptioa baoaua* I
obtain th* aotin ingradiut
from tha •euro* EPA x*9ia-
brat ion number li»t«d below.

6b. I «graa to ntiafy Ouwrio
Data requirement* a* indicated
on the attached form entitled
"EtequicemBbt* Status and
Re^i»tr«nt ' • EUaponaa . "

3 . Date and Type of DC I
GENERIC
7. Product Spaalflo Data
7a. My prodaot ia an MOP and
I agree to aatiafy the MOP
requirement* oa the attaohed
fcxm entitled "Requlrouenta
Statiia and Reglatrant' •
Re*pon**.n

B. CartiftoafcioB
I o«rtify that th« >bab*n*nt* Bad. on thi. fora and all nttaoluMnt* «• tru», aaourkt*, and conpl«t«,
I aoknoirl.dg. that any knowingly f«l» or mi.lMdlug «t»t«wttt »y b» punl«li«bla by tint, iBpriaonm.nt
or both undw: applicable law.
10. Nan* of Company Contact

I agree to aatiify the EOT
requirement* on the attached
fora entitled "Requirement*
Status and Registrant'*
Re*pon*e , "

9. Date
11,
f hone Number

-------

-------
     Product Specific



Data Call-In Response Form

-------

-------
DRAFT  COPY
Page  1 of  1
United States Environmental Protection Agency Form Approved
Washington,- D. C. 20460 «. fc. ZOHH.W
DATA CALL-IN RESPONSE A ^f0-005^ „ Oi
Approval Expires 03-31-96
INSTRUCTIONS; Please type or print in ink, Please read carefully the Attached Instructions and supply the Information requested on this form.
Use additional sheet (s) 1f necessary.
1. Conpany name and Address 2. Case # and Name
SAMPLE COMPANY 0024 Boric Acid & its
NO STREET ADDRESS
NO CITY, XX OOOOO
4. EPA Product
Registration
NNNNNN-NNNNN
5. I wish to
cancel this
product regis-
tration volun-
tarily.

6. Generic Data
6a. 1 am claiming a Generic
Data Exemption because I
obtain the active ingredient
from the source EPA regis-
tration number listed below.
N.A.

6b. I agree to satisfy Generic
Data requirements as indicated
on the attached form entitled
"Requirements Status and
Registrant's Response."
N.A.
3, Date and Type of DC I
Sodium Salts PRODUCT SPECIFIC
7. Product Specific Data
7e. My product is a HUP and
I agree to satisfy the HUP
requirements on the attached
form entitled "Requirements
Status and Registrant's
Response."


7b. My product is an EUP and
I agree to satisfy the EUP
requirements on the attached
form entitled "Requirements
Status and Registrant's
Response."

fl. Certification '• Date
1 certify that the statements made on this form and all attachments are true, accurate, and complete.
] acknowledge' that any knowingly false or misleading statement may be punishable by fine, imprisonment
or both under applicable law.
Signature and Title of Company's Authorized Representative
10. Name of Company Contact n- Phone Number

-------
                   Attachment 3



 Generic  and Product  Specific Data Call-in Notice



Requirements Status and Registrant's Response Forms



                 With Instructions

-------
                   Instructions For Completing
                               The
      "Requirements Status and Registrant's Response Forms"
        For The Generic and Product Specific Data Call-in
INTRODUCTION

     These instructions apply to the Generic and Product Specific
"Requirements Status and Registrant's Response Forms" and are to
be used by registrants to respond to generic and product specific
Data Call-in's as part of EPA's reregistration program under the
Federal Insecticide, Fungicide, and Rodenticide Act.  The type of
Data Call-in  (generic or product specific) is indicated in item
number 3 ("Date and Type of DCI") on each form.  Both
"Requirements Status and Registrant's Response" forms must be
completed.

     Although the form is the same for both product specific and
generic data, instructions for completing the forms differ
slightly.  Specifically, options for satisfying product specific
data requirements do not include (1) deletion of uses or (2)
request for a low volume/minor use waiver.  Please read these
instructions carefully before filling out the forms.

     EPA has developed these forms individually for each
registrant, and has preprinted these forms to include certain
information unique to this chemical. DO NOT use these forms for
any other active ingredient.

     Items 1 through 8 have been preprinted on the form.  Item 9
must be completed by the registrant as appropriate.  Items 10
through 13 must be completed by the registrant before submitting
a response to the Agency.

     The public reporting burden for this collection of
information is estimated to average 30 minutes per response,
including time for reviewing instructions, searching existing
data sources, gathering and maintaining the data needed, and
completing and reviewing the collection of information. Send
comments regarding the burden estimate or any other aspect of
this collection of information, including suggestions for
reducing this burden, to Chief, Information Policy Branch, Mail
Code 2136, U.S. Environmental Protection Agency, 401 M St., S.W.,
Washington, D.C. 20460; and to the Office of Management and
Budget, Paperwork Reduction Project 2070-0107, Washington, D.C.
20503.

-------
INSTRUCTIONS FOR COMPLETING THE "REQUIREMENTS, STATUS AND
REGISTRANT'S RESPONSE FORMS"
Generic and Product Specific Data Call-in
Item 1.   ON BOTH FORMS:  This item identifies your company name,
          number and address.

Item 2.   ON THE GENERIC DATA FORM:  This item identifies the
          case number, case name, EPA chemical number and
          chemical name.

          ON THE PRODUCT SPECIFIC DATA FORM:  This item
          identifies the  case number,  case name,  and the EPA
          Registration Number of the product for which the Agency
          is requesting product specific data.

Item 3.   ON THE GENERIC DATA FORM:  This item identifies the
          type of Data Call-in.  The date of issuance is date
          stamped.

          ON THE PRODUCT SPECIFIC DATA FORM:  This item
          identifies the type of Data Call-in.  The date of
          issuance is also date stamped.  Note the unique
          identifier number (ID#) assigned by the Agency.  This
          ID number must be used in the transmittal document for
          any data submissions in response to this Data Call-in
          Notice.

Item 4.   ON BOTH FORMS:  This item identifies the guideline
          reference number of studies required.  These
          guidelines, in addition to the requirements specified
          in the Data Call-in Notice, govern the conduct of the
          required studies.  Note that series 61 and 62 in
          product chemistry are now listed under 40 CFR 158.155
          through 158.180, Subpart c.

Item 5.   ON BOTH FORMS:  This item identifies the study title
          associated with the guideline reference number and
          whether protocols and 1, 2, or 3-year progress reports
          are required to be submitted in connection with the
          study.  As noted in Section III of the Data Call-in
          Notice, 90-day progress reports are required for all
          studies.

          If an asterisk appears in item 5, EPA has attached
          information relevant to this guideline reference number
          to the Requirements  Status and Registrant's Response
          Form.

-------
INSTRUCTIONS FOR COMPLETING THE ^VREOUIREMENTS STATUS AND
REGISTRANT'S RESPONSE FORMS"
Generic and Product Specific Data Call-In

Item 6.   ON BOTH FORMS:  This item identifies the code
          associated with, the use pattern of the pesticide.  In
          the case of efficacy data {product specific
          requirement), the required study only pertains to
          products which have the use sites and/or pests
          indicated.  A brief description of each code follows:

          A    Terrestrial food
          B    Terrestrial feed
          C    Terrestrial non-food
          D    Aquatic food
          B    Aquatic non-food outdoor
          F    Aquatic non-food industrial
          G    Aquatic non-food residential
          H    Greenhouse food
          I    Greenhouse non-food crop
          J    Forestry
          K    Residential
          L    Indoor food
          M    Indoor non-food
          N    Indoor medical
          0    Indoor residential

Item 7.   ON BOTH FORMS:  This item identifies the code assigned
          to the substance that must be used for testing. A brief
          description of each code follows:

          EUP            End-Use Product
          MP             Manufacturing-Use Product
          MP/TGAI        Manufacturing-Use Product and Technical
                              Grade Active Ingredient
          PAI            Pure Active Ingredient
          PAI/M          Pure Active ingredient and Metabolites
          PAI/PAIRA      Pure Active Indredient or Pute Active
                              Ingredient Radiolabelled
          PAIRS.          Pure Active Ingredient Radio label led
          PAIRA/M        Pure Active Ingredient Radiolabelled
                              and  Metabolites
          PAIRA/PM       Pure Active Ingredient Radiolabelled
                              and Plant Metabolites
          TEP            Typical End-Use Product
          TEP 	%       Typical End-Use Product, Percent
                              Active Ingredient Specified
          TEP/MET        Typical End-Use Product and Metabolites
          TEP/PAI/M      Typical End-Use Product or Pure Active
                              Ingredient and Metabolites

-------
INSTRUCT I QMS FOR COMPLETING THE "KEQUIRJ5MEMT5 STATUS AND
REGISTRANT'S RESPONSE FORMS"
Generic and Product Specific Data Call,-^In
          TGAI           Technical Grade Active Ingredient
          TGAI/FAI       Technical Grade Active Ingredient or
                              Pure Active Ingredient
          TGAI/PAIRA     Technical Grade Active Ingredient or
                              Pure Active Ingredient
                                   Radiolabelled
          TGAI/TEP       Technical Grade Active Ingredient or
                              Typical End-Use Product
          MET            Metabolites
          IMP            Impurities
          DEGR           Degradates
          *              See: guideline comment

Item 8.   This item completed by the Agency identifies the time
          frame allowed for submission of the study or protocol
          identified in item 5.

          ON THE GENERIC DATA FORM:  The time frame runs from the
          date of your receipt of the Data Call-In notice.

          ON THE PRODUCT SPECIFIC DATA FORM:  The due date for
          submission of product specific studies begins from the
          date stamped on the letter transmitting the
          Reregistration Eligibility Decision document, and not
          from the date of receipt.  However, your response to
          the Data Call-in itself is due 90 days from the date of
          receipt.

Item 9.   ON BOTH FORMS:  Enter the appropriate Response Code or
          Codes to show how you intend to comply with each data
          requirement. Brief descriptions of each code follow.
          The Data Call-in Notice contains a fuller description
          of each of these options.

     Option 1. ON BOTH FORMS:   (Developing Dafca) I will conduct a
               new study and submit it within the time frames
               specified in item 8 above. By Indicating that I
               have chosen this option, I certify that I will
               comply with all the requirements pertaining to the
               conditions for submittal of this study as outlined
               in the Data Call-in Notice and that I will provide
               the protocols and progress reports required in
               item 5 above.

     Option 2. ON BOTH FORMS:   (Agreement to Cost Share) I have
               entered into an agreement with one or more
               registrants to develop data jointly. By indicating

-------
INSTRUCTIONS FOR COMPLETING _THE "REQUIREMENTS STATUS AMD
REGISTRANTS RESPONSE FORMS"
Generic and Product Specific Data Call~In
               that I have chosen this option,  I certify that I
               will comply with all the requirements pertaining
               to sharing in the cost of developing data as
               outlined in the Data Call-in Notice.

                    However, for Product Specific Data, I
               understand that this option is available for acute
               toxicity or certain efficacy data ONLY if the
               Agency indicates in an attachment to this notice
               that my product is similar enough to another
               product to qualify for this option. I certify that
               another party in the agreement is committing to
               submit or provide the required data; if the
               required study is not submitted on time, my
               product may be subject to suspension.

     Option 3. ON BOTH FORMS:  (Offer to Cost Share) I have made
               an offer to enter into an agreement with one or
               more registrants to develop data jointly.  I am
               also submitting a completed "Certification of
               offer to Cost Share in the Development of Data"
               form.  I am submitting evidence that I have made
               an offer to another registrant (who has an
               obligation to submit data)  to share in the cost of
               that data.  I am including a copy of my offer and
               proof of the other registrant's receipt of that
               offer.  I am identifying the party which is
               committing to submit or provide the required data;
               if the required study is not submitted on time, my
               product may be subject to suspension. I understand
               that other terms under Option 3 in the Data
               Call-In Notice apply as well.

                    However, for Product Specific Data,  I
               understand, that this option is available only for
               acute toxicity or certain efficacy data and only
               if the Agency indicates in an attachment to this
               Data Call-In Notice that my product is similar
               enough to another product to qualify for this
               option.

     Option 4. ON BOTH FORMS:  (Submitting Existing Data^  I will
               submit an existing study by the specified due date
               that has never before been submitted to EPA.  By
               indicating that I have chosen this option, I
               certify that this study meets all the requirements
               pertaining to the conditions for submittal of

-------
INSTRUCTIONS FOR COMPLETING THE "REQUIREMENTS STATUS AND
REGISTRANT'S RESPONSE FORMS"
Generic and Product Specific Data Call-in
               existing data outlined in the Data Call-in Notice
               and I have attached the needed supporting
               information along with this response.

     Option 5. ON BOTH FORMS:   (Upgrading a.._S.tudy)  I will submit
               by the specified due date, or will cite data to
               upgrade a study that EPA has classified as
               partially acceptable and potentially upgradeable.
               By indicating that I have chosen this option, I
               certify that I have met all the requirements
               pertaining to the conditions for submitting or
               citing existing data to upgrade a study described
               in the Data Call-in Notice. I am indicating on
               attached correspondence the Master Record
               Identification Number  {MRID} that EPA has assigned
               to the data that I am citing as well as the MRID
               of the study I am attempting to upgrade.

     Option 6. ON BOTH FORMS:   (Citing a Study)  I am citing an
               existing study that has been previously classified
               by EPA as acceptable, core, core minimum, or a
               study that has not yet been reviewed by the
               Agency. If reviewed, I am providing the Agency's
               classification of the study.

                    However, for Product Specific Data,  I am
               citing another registrant's study.  I understand
               that this option is available ONLY for acute
               toxicity or certain efficacy data and ONLY if the
               cited study was conducted on my product, an
               identical product or a product which the Agency
               has "grouped" with one or more other products for
               purposes of depending on the same data. I may also
               choose this option if I am citing my own data. In
               either- case, I will provide the MRID or Accession
               number  (s).  If I cite another registrant's data,
               I will submit a completed "Certification With
               Respect To Data Compensation Requirements" form.

     FOR THE GENERIC DATA FORM ONLY:  The following three options
      (Numbers 7, 8, and 9) are responses that apply only to the
      "Requirements Status and Registrant's Response Form" for
     generic data.

-------
INSTRUCTIONS FOR COMPLETING THE "REQUIREMENTS STATUS AND
REGISTRANT'S RESPONSE FORMS"
Generic and Product Specific Data .Call-in
     Option 7. (Deleting Uses)  I am attaching an application for
               amendment to my registration deleting the uses for
               which the data are required.

     Option 8. (Low Volume/Minor Use Waiver Request) I have read
               the statements concerning low volume-minor use
               data waivers in the Data Call-in Notice and I
               request a low-volume minor use waiver of the data
               requirement. I am attaching a detailed
               justification to support this waiver request
               including, among other things, all information
               required to support the request. I understand
               that, unless modified by the Agency in writing,
               the data requirement as stated in the Notice
               governs.

     Option 9. (Request for Waiver of Data) I have read the
               statements concerning data waivers other than low-
               volume minor-use data waivers in the Data Call-In
               Notice and I request a waiver of the data
               requirement. I am attaching a rationale explaining
               why I believe the data requirements do not apply.
               I  am also submitting a copy of my current labels.
               (You must also submit a copy of your Confidential
               Statement of Formula if not already on file with
               EPA). I understand that, unless modified by the
               Agency in writing,  the data requirement as stated
               in the Notice governs.

     FOR PRODUCT  SPECIFIC DATA:  The following option (number 7)
     is a response that applies to the "Requirements Status and
     Registrant's Response Form" for product specific data.

     Option 7.  (Waiver Requesti   I request a waiver for this
               study because it is inappropriate for my product.
               I  am attaching a complete justification for this
               request, including technical reasons, data and
               references to relevant EPA regulations,  guidelines
               or policies. [Note: any supplemental data must be
               submitted in the format required by P.R. Notice
               86-5].  I understand that this is my only
               opportunity to state the reasons or provide
               information in support of my request. If the
               Agency approves my waiver request,  I will not be
               required to supply the data pursuant to Section
               3(c)  (2)  (B)  of FIFRA. If the Agency denies my
               waiver request, I must choose a method of meeting

-------
INSTRUCTIONS FOR COMPLETING THE "REQUJRjEMENTS STATJIS_ AND
REGISTRANT'S RESPONSE FORMS"
Generic and Product Specific Data Call-in
               the data requirements of this Notice by the due
               date stated by this Notice. In this case, I must,
               within 30 days-of my receipt of the Agency's
               written decision,, submit a revised "Requirements
               Status" form specifying the option chosen. I also
               understand that the deadline for submission of
               data as specified by the original Data Call-in
               notice will not change.

Item 10.  ON BOTH FORMS: This item must be signed by an
                         authorized representative of your
                         company. The person signing must include
                         his/her title, and must initial and date
                         all other pages of this form.

Item 11.  OH BOTH FORMS: Enter the date of signature.

Item 12.  ON BOTH FORMS: Enter the name of the person EPA should
                         contact with questions regarding your
                         response.

Item 13.  ON BOTH FORMS: Enter the phone number of your company
                         contact.
NOTE:     You may provide additional information that does not
          fit on this form in a signed letter that accompanies
          this your response. For example, you may wish to report
          that your product has already been transferred to
          another company or that you have already voluntarily
          cancelled this product. For these cases, please supply
          all relevant details so that the Agency can ensure that
          its records are correct.

-------
                      Generic




Requirements Status and. Registrant's Response Form

-------

-------
DRAFT   COPY
                                                                                      Page  1  of 1
United States Environmental Protection Agency
Washington, B.C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE
INSTRUCTIONS; Please type or print in ink. Plaasa read carefully the attached instructions and supply tha information requested
Use additional sheet (a) if nacesaax-y
1. Company name and Address

1. Guideline
Requirement
Number
: 123-l;i[a);: ,; * .
123-2 *
5. Study Title
Saad gam/gaedJ-incf ensrj
Aquatic plant growth
P
R
§
O
C
O
L


2. Cue f and Mama
0024 Boric Acid
Chemical t and Name 011001
Borifl aoid
Prograas
Reports
1


2


3


6. Use
Pattern
CJK. 	 	
CJK
7. Teat
Substance
TCAI
TQAI
10. Certification
I certify that tha atati
I aoknowledge that any 1
OK both under applicabli
Signature and Title of (
unanta made on this font and all attachment* are true, accurate, and complete.
cnowingly falsa oc mis leading statement may be punishable by fine, imprisonment
s Law.
Company' a Authorized E«pi«»antativa


12 . Dane of Company Contact


Form Jkpprovod
OMB Ho. 2070-0107
2070-0057
Approval Expires 03-31-96
on thia fa™.

3. Date and Type of DCI
GENERIC
FEB
B. Time
Frame
12
12
mo s .
mos .
6 1994
9 . Ragiatrant
Response


11. Data


13. Phono Number

-------
	Page 1 of 1
                             United States Environmental Protection Agency
                                        Washington,  D.C. 20460

                               * COMIKNT3 FOR GUIDELINE REQUIREMENTS

 Casa t and Naina
 0024   Boric Acid
 Chemical £ and. Name
 011001  Boric acid

 GUIDELINE    COMMENT

 123-1 la)  The  herbicTdal uses justify the requirement  of  phytotoxicity studies  in  orcler to further
          assess  the potential risks to non-target  and endangered plant species.

 123-1 (b)  Refer to comment for 123-1 (a) .

 123-2     Refer to comment for 123-1 (a) .

-------
D R A F T   COPY
Page 1 of 1
United States Environmental Protection Agency
Washington, B.C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE
INSTRUCTIONS : Fle«9« Hyps or print in ink. Plsass read carefully the attaohad Instructions and uupply tha information requested
U«e additional 3h«et(9) if naceasary
1 . Company name and Address
4. Guideline
R«quir«maat
Nunbac
123-1 (a) *
•i23Hf;flby'- ' •=•*
123-2 *
5. Study Title
Seed get nw' seedling eotacq;
Vegatatitr* *i^iir '' ' : :•:'•• -: : .
A
-------
     	Page  1  of 1
                            United. States Environmental Protection Agency
                                        Washington, B.C.  20460

                               *  COMMRNTS FOR GUIDELINE REQUIREMENTS

Caa* f and Mama
0024  Boric Acid
Chemical t and Mama
011102  Borax

OTIDEL1NE    COMMENT

123-1 (a)  The  herbicidal  uses  justify  the requirement of phytotoxicity studies in order to  further
          assess the potential risks to non-target and endangered  plant species.


123-1 (b)  Refer to comment  for 123-1 (a).

123-2     Refer to comment  for 123-1 (a).

-------
DRAFT   COPY
                                                                                     Page 1 of 1
United States Environmental Protection Agency
Washington, D.C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE
INSTRUCTIONS: Plaaaa type or print In inlt , Pleaaa raad carefully the attached Instructions and supply the information requested
Use additional sheet (3) if necessary
1 . Company natue and Address
4 . Guideline
Requirement
Number
123-1 {.a) , . *
123-2 *
5 . Study Title
Vajatafeilwa '-'i&gcaz'- •'-.''-''--'''''--''' -.':.''-''- \.^':-"--l:^\:'''<-.:-
Ac/uatic plant -growth
10. Certification
X acknowledge that any 1
or both under applicable
Signature and Title of <
mowingly false of misleading statement
» latr,
2otnpsny' 9 Authorized Representative
I
0
1
0
C
o
L

2 . Caae f and Hame
0024 Boric Acid
Chemical f and Haae 011110
Sodium Tetraborate Pentahydrate
Progxeas
Reports
1

2

3

6. Use
Pattern
CJK,,...
CJK
imontB are true, accurate, and oomplete.
t may be. punishable by fine, imprisonment

7. Teat
Substance
TfflAI
TOAI

12 . Name of Company Contact
Fora Approved
OMB No. 2010-0107
20TO-OO57
Approval Empires O3-31-9E
on this form .
3. Data and Type of DC I
GENERIC
FEB [ 6 1994
8. Time
Frame
I?
12
mos ,
9. Registrant
Response

11. Date
13 . Phoria Mumbar

-------
                                           	Page  1 of 1
                            United States Environmental Protection Agency
                                        Washington, D.C. 20460

                               *  COWfflNTS FOR GUIDELINE REQUIREMENTS


Csaa f and Nama
0024  Boric Acid
Chemical f and Name
011110   Sodium  Tetraborate Pentahydrate

GUIDELINE    COt*£WT

123-1 (a)  The  h.erbicidal uses  justify the requirement of phytotoxicity  studies in order to further
          assess the potential risks  to non-target and endangered plant species.

123-1 (b)  Refer- to comment for 123-1 (a) .

123-2     Refer to comment for 123-1 (a) .

-------
DRAFT
COPY
_Page 1  of 1
United States Environmental Protection Agency
Washington, D.C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE
INSTRUCTIONS: P Issue type of print In ink. Fleasa raad oacsfully tha attaohad instructions and supply the information requested
Usa additional sheet (a) if necessary
1 . Company name and Addrasa

4 . Guideline
Requirement
Number
123-1 (a) *
123-2 *
5. Study Title
Seed germ/seedling; energ
Aquatic plant growth
P
R
O
T
O
O
L


2. Case f and Kama
0024 Boric Acid
Chemical f and Name 011112
Sodium Tetraborate Anhydrous
Program
Reports
1


2


3


6. Use
Pattern
CJK
CJK
Substance
TGAI
TGAI
10. Certification
I certify that the atat
I acknowledge that any
or both under applicabl
Signature and Title of (
amsr.ts mada on this form and all attachments are true, accurate, and complete.
knowingly false or misleading statement may be punishable by fine, imprisonment
Company's Authorized Representative


12 . Name of Company Contact
FOETD App*roT*d
OMB No, 2O10-0107
20-70-0057
Appcoiral Expires 03-31-96
on this focm.

3. Date and Type of DCI
GENERIC
FEB
B. Time
Frame
12
12
mos .
mos .
:6 1994
9. Efigistrant
Response


11. Date


13 . Phona Humbec

-------
                                                                                          Page 1 of 1
                            United States Environmental Protection  Agency
                                       Washington,  D.C. 20460
                              * COiMENTS FOR GUIDELINE KBQUXBEKEHTS
Caaa f and Mama
0024  Boric Acid
Chenioal f and Hana
011112   Sodium Tetraborate Anhydrous
GUIDELINE    COMMENT
123-1 (a)  The herbicidal uses justify the requirement of phytotoxicity studies  in order to further
          assess the potential risks to non-target and endangered plant species.

123-1 (b)  Refer to comment for 123-1 (a).

123-2     Refer to comment for 123-1 (a) .

-------
DRAFT
COPY
Page 1 of 1
United States Environmental Protection Agency
Washington, D.C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE


Pona J^provad
OMB Ho. 2070-0107
2070-0057
Approval Expires 03-31-96
INSTRUCTIONS: Please typa or print in ink. Please read carefully tha attaohad instructions and supply the information raqusstad on this form.
Use additional »haat(s) if nacaasary
1. Company name and Address

t. Guideline
Dumber
12 3-1 (a) 	 *
123-2 *
5. Study Title
Saed jarm/Baedling «ni«rg
Vocf«t4tive :*3i<)tJr' '•' • • . . '• '','".
Aquatic plant growth
e
0
T
O
C
O
L


2. Caaa t and Name
0024 Boric Acid
Chenical f and Mama 011103
Diaodlum oobaborate tetrahydrat*
Report *
1


2


3


6. Usa
Pattern
CJK
CJK:- " '•:;••
CJK
7, Test
Substance
TGAI
Ttai
TGAI
10. Certification
I certify that the statements mods on this, fono and all attachment* are true, accurate, and complete.
I acknowledge that any knowingly false of misleading *tat«i«nt nay be punishable by fins, imprisonment
or both under applicable lav.
Sionatura and Title of Company's Authorized Representative
12 . Name of Company Contact

3. Data and Type of DGI
GENERIC
H-U [ 6 1994
8. Time
Frame
12
12
12
mo s.
KIDS.
mos.
9 . Registrant
Raaponao


11. Data


13 . Phone number

-------
                             	Page 1  of 1
                           United States Environmental Protection Agency
                                       Washington,  D.C.  20460

                              * COtWENTS FOR GUIDELINE BBQUXBKMENTS


Caaa f and Hama
0024  Boric Acid
Chemical t >nd Kama
011103  Disodium octaborate  tetrahydrate
KHDBLINE    COMMENT
123-1 (a)  The  herbicidal uses justify the requirement  of phytotoxicity studies in order to  further
          assess the potential risks to non-target  and endangered plant species.

123-1 (b)  Refer to comment for 123-1 (a) .

123-2     Refer to comment for 123-1 (a) .

-------
DRAFT
COPY
Page 1 of 1
United States Environmental Protection Agency
Washington, D.C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE
INSTRUCTIONS ! E lease type or print in ink. Plaaaa raad carafully th» attached instruotiona and supply tha information request ad
Us a additional sheet (a) if ntsnnssafy
1 . Company nam« and Actdra60
4. Guideline
Raquicanont
tlmnr'ar
123-1 
-------
                                                       	Page 1 of 1
                            United States Environmental Protection Agency
                                        Washington, D.C.  20460
                               *  COKMBHTS FOR GUIDELINE REQUIREMENTS
   f and Homo
0024  Boric Acid.
Chemical f and Home
011107  Disodium Octaborate Anhydrous
GUIDELINE    COMMENT
123-1 (a)  The herbicidal uses  justify the requirement of phytotoxicity studies in oder to  further
          assess the potential  risks  to non-target and endangered plant species.

123-1 (b)  Refer to  comment  for  123-1 
-------
DRAFT COPY
Page 1 of 1
United States Environmental Protection Agency
Washington, D.C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE
INSTEUCTIOHS: Elaaaa typa or print In ink, P1»»S9 read carefully the attached ii
Uae additional aheat(a if naaaaaary
1. Company name and Addrasa 000X00
CIBA-GEIGY CORP.
P.O. BOX 18300
GREENSBORO NC 27419
4 . Quid* lino
Ra information rwqUHated
2 . Cag« f and Name
0632 Barium metaborate
Chemical f and Hama 011104
Sodiim mataborate
Pr ogees B
Report a
1


2


3

6. Uae
Pattarn
CJK
GtffC : "' -: = !
CJK
7 . Taat
3ub«tano«
TGAI
TGRI
TGAI
10. Certification
I certify that the statements mada on thia forn end all attachments are trua, accurate, and complete.
I ao)cnoHl«dg;a that any knowingly £ala« or misleading statement may be punishable by fine, imprisonment
or both under applicable lav.
Signature and lit la of Company' a Authorized RepreeentatiTO
12 . NanB of Company Contact
Form Approved
OMB No. 2070-0107
2070-0057
Approval Expires 03-31-96
on this form .
3. Data and 2ypa of DC I
GENERIC ijgn hAf^M
a. Time
Trarne
12
%2
12
mos.
. mos 4
mos .
9 . Ragistcant
Response

11. Date
13 . Phone Number

-------
                                                                                          Page  1  of 1
                            United States Environmental  Protection Agency
                                        Washington, D.C. 20460
                               * COMOENTS TOR GUIDELINE REQUIREMENTS
Caa« 4 and Hans
0632  Barium metaborate
Chemical I and N«ne
011104   Sodium metaborate
CU1DELINE    COMMENT
123-1 (a)  The herbicidal uses justify  the requirement of phytotoxicity studies in order to  further
          assess the potential risks to  non-target and endangered plant species.

123-1(b)  Refer to comment  for 123-1
-------
                 Product Specific



Requirements Status and Registrant's Response Form

-------

-------
         DRAFT   COPY
                          United  States Environmental  Protection Agency
                                         Washington,  D. C.  20460

                          REQUIREMENTS  STATUS AMD  REGISTRANT'S  RESPONSE
                                                                                                  Page  1  of    3

                                                                                               Form Approved

                                                                                               OMB Ho. 2070-0107
                                                                                                     2070-0057
                                                                                               Approval Expires 03-31-96
INSTRUCTIONS: Please type or print  in ink.  Please read carefully the attached instructions and supply the information requested on this form.
use additional sheet(s)  if necessary.
1. Company name and Address
   SAMPLE COMPANY
   NO  STREET ADDRESS
   NO  CITY,   XX  OOOOO
                                 2. Case # and Name
                                    0024   Boric  Acid  ft its Sodium

                                    EPA Reg.  No.  NNNNNN-NNNNN
                               Salts
                             3. Date and Type of DC!
                               PRODUCT SPECIFIC
                               ID#  NNNNNM-RD-NNNN
                                      FE6  I61994
4. Guideline
Requirement
Mumber
5. Study Title
Progress
Reports
6. Use
Pattern
 7, Test
 Substance
8. Time
Frame
                                                                                                                              9. Registrant
                                                                                                                              Response
                    Prod Chen - Regular Chemical
61-
61-2
:x:.;" J> = ;

62-1

62-3

63-3
63-7
63^12;'!;;.
63-14
 Product  identity & composition (1,50>
i&Setf^h^staW^                     !:O
  productn 8 formulatn
   •••      -     '       -- - -  ••••"••••—•••    -
                                                                           ABCDEFG
                      JKLMNO
                     : JKLMNO'
                    MP/EP
                                                                                               . ...-;- _;••_ ;.:.*'. .-.;.'-:

                                                                                                B  mos.
                    ;;:::; pi-:cicess .-;^'.;*£?'-'.--\;'
                     Discussion of  formation of
                          £1,3,50)

                         .:;JH/-T-::"' ..... -"'T1- ••:••••'
 Preliminary analysis         (1,4,50)
 eeafificatl^fM^
 Analytical method            C1,50)
.toi:t»r;': \:;;'" /.M'--^
 Physical state
 qdo-'r-1"  :\\:  "T-^ H^ :;-!:" '
 Density                   (50}
 PH •;;;-   -  :--:. --\-^^^. :cso>: !:::: •• -;• •'•:
 Oxidizing or reducing action   (1,50>
                                                       ABCDEFG  JKLMNO
                                              (50)
          ABCDEFG
          ABCDEFG
          ABCDEFG
          ABCDEFG
          ABCDEFG
          ABCbEFG
          ABCDEFG
          ABCDEFG
          ABCDEFG
                                                                                       JKLMNO
           JKLMNO
           JKLMNO
           JKLMNO
           JKLMNO
           JKLMNO
           JKLMNO
           JKLMNO
MP/EP


MP/EP
MP^EPJ
. •-:- *. -.-:-  :
MP/EP
MP/EP
MP/EP:.  ;
MP/EP
MP/EP;:  i
MP/EP
 8 mos.

 8 mos.
; sT'ttibs^
 8 mos.
 ft; ;ri6^ ;•
 8 mos.
 isifflibs'.
 8 mos.
 Sj.impfe';
 8 mos.
10, Certification
I  certify that the statements made on this -form and all attachments are true, accurate, and complete.
I  acknowledge that any knowingly false or misleading statement may be punishable by fine,  imprisonment
or both under applicable law.

signature and Title of Company's Authorized Representative                            ......
                                                                                                    11. Date
1H. Name of Company Contact
                                                                                                     !. Phone Number

-------
DRAFT COPY


United States Environmental Protection Agency
Washington, D. C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE
INSTRUCTIONS: Please type or print in ink. Please read carefully
Use additional sheet(s) if necessary.
1. Company name and Address
SAMPLE COMPANY
NO STREET ADDRESS
NO CITY, XX OOOOO
4, Guideline
Requi rement
Number
63-17
63-20
81-1
81-4
8 i^.5-v^:.::.:;r^::: •;''•'
81-6
•• ": ".. -., -• ':' - :'•': -:•:.•".:" I .: ' '" .'
95-2,3
95-2,3
5. Study Title
:EXpl<^feiil;iity::y:v:;;?i|.;i:-':ili:^:^i*:^lfe5iP?''
Storage stability (50)
M ^iestfiijirpi': v; ;J: *; ^M %^-M^& s .NsVSQI -;;
Corrosion characteristics (50)
Acute Toxic - Regular Chemcat
Acute oral toxicity-rat (1,7,50)
toxfeity-rabbU/rat
•^ \Actii &$ WfiSfft' i^^^iMty^ra't^ '& ;So>; •. . •
Primary eye irritation-rabbit (2,50)
; :iPriii^r^^i-felHirjri;tiittbiv> '•!>.' :'.(-lV2iBO")
Dermal sensitization (4,50)
Efficacy - Invertebrate Control Agents
Foliar and General Soil
the attached instructions and supply the
information requested
2. Case # and Name
0024 Boric Acid & its Sodium Salts
EPA Reg. No. NNNNNN-NNNNN

'; l''.1'1 V; .;
^Treatments' : .>' ".:.;;; ;T; ;;;._ -:: ';;•• "..;...;..--. '•'•'":-•':
Laboratory efficacy (50,51,56)
-; '; : evaluation,; y-\'f-.'-^ ••• ;•.".:: •" ''".': " : ' :
Comparative field test (50,51,56)
0
s;-
N ':
Progress
Reports
1
l:?-&
2
••I'lv": •;"
;.;-.-• -:- -
3
:;.;:,
6. Use
Pattern
ABCDEFG
ABCBEFGl
ABcbEFG
ABCDEFG
ABCDEFG
ABCDEFG
ABC
ABC
Initial to indicate certification as to information on this page
(full text of certification is on page one).
JKLMNO
JKLMNb
JKLMNO
| JKljMNO
:: JKMINO
JKLMNO
• .'.TVT WTM^ii
-- U JS'J- E"JU" W
JKLMNO
JKLM 0
JKLM O
Page 2 of 3

form Approved
OMB No. 2070-0107
2070-0057
Approval Expires 03-31-96
on this form.
3. Date and Type of DC I
PRODUCT SPECIFIC
ID# NNNNNN-RD-NNNN
FEB I6B94
7. Test
Substance
«P/EP
MP/EP
U.^iJ:i:^.-r^..Mr..:,= ;;N;;-::
MP/EP
MP^Ep;::f;K'':-.-^>m:r;':
MP/EP :-:• '- $•'-«-•*.
MP/EP
MP/EP i ';::':; ;'-:":!,
MP/EP
EP
EP
8. Time
Frame
8 mos.
8 mos.
8 mos.
8 mos.
8 mos.
3 mos.
8 mos .
9. Registrant
Response
. -;. ''!. : — -'" - 	 i
'.' " ' ."-•" -- -- -'"'.• -I1" . '. .-
Date

-------
DRAFT  COPY
Page  3 of
United States Environmental Protection Agency
Washington, D. C. 20460
REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE
INSTRUCTIONS: Please type or print in ink. Pleasa read carefully
Use additional sheet(s) if necessary.
1 . Company name and Address
SAMPLE COMPANY
NO STREET ADDRESS
NO CITY, XX 00000
4. Guideline
Requi rement
Number
^3fflM:*0&-
'9 &s.il:6';ffi jMv^rwC.1


95-12
;:•: 	 ;-- . - x...-. •:- j: :•:..;. .y • ; ;=--_-. .. ':" -;:: '
95-12
95-13 	
95-13
the attached instructions and supply the

information requested

2. Case # and Name
0024 Boric Acid & its sodium Salts
EPA Reg. No. NNNNNN-NNNNN
5. Study Title
Di^ife;iAhi«^^s^p^eir^ rT.;:V7\ -; • •*
KaTMnade Premises
;.;;'jtai^reto:r:yj,ieff;tt*iiey.;J: •] ;.• -;,'.:' / <$jS;52i?JI:
evaluation
;:;?^<:<^j?Bfitf^
Premises Treatments
*^fii-tiai^paSi»r¥i.^eNi...;..:-;:.;.;^;-i.
^.;|HV

oc^iy^
Laboratory efficacy (50,54,56)
': " -'-'-•- V.^V^ldlitT Oil V- - -:-:-' ':'.-y •" '-'• ••:"••:"•"-":."" : . : .:--'' '- - ' •-

Comparative field test (50,54,56)
Laboratory efficacy (50,55,56)
Comparative field test (50,55,56)
1
0
" !:;|'|
K




'••'.'•:

Progress
Reports
1
'-'"-
'i' ;';";:'
..:,-;.,

~&&-
.:-:'.-'
= ^:'.f

2
%'$•
;•-••• '*..
.--.'•::-

'-.-'- '-I ':-!•'
:•.-.••• _,• •• .•.


3
::-M-:C
•••i-;.'::;;-
....... •.....•.:.•

^:,:,;;.

•:.-.:-,'•

6. Use
Pattern
j Li: ; ;^ S K '- :
.•;.-:..::-;..;. .-I.-:.,;/.;.;-:-
£H3l-!?=-

^"---••:^;C;;
•"""!•.. ". ::: ""..""":". ":" r .-
,'L- : "•; - ""•

Initial to indicate certification as to information on this page
(full text of certification is on page one).
::; ; : si :: : VI" .
v^r-K'ft-""^^
-^Kt^O

K MO
: ..;' : ' •:.••:•: :._• _";
K M O
LM 0
LM 0
Form Approved
OMB Mo. 2070-0107
2070-0057
Approval Expires 03-31-96
on this form.

3. Date and Type of DCI
PRODUCT SPECIFIC
ID# NNNNNN-RD-NNNN
FEB 161991
7. Test
Substance
S"-":-'.-.!:"!'!';' "-
EP.: :•..;.••;:•.:;
Bp.^::v

EP
• '•! 	
EP
EP
EP
.^••|":'-''V'VH'
:.;;.:.;:;•..:;.;.:..:.:;-•;:-.:.;.;;..
.,,,:.,.^,.v.::,,.:.

;"•"•••••::.•'•:"•":-"•":•

. 'f ..... -_. ..-•.;:
-• _ ; .-"'.::- -.

8. Time
Frame
;.::^^..i,;,.r,;
;:.;:.8v,inOS..-
v^^r

8 mos.

8 mos.
8 mos.
8 mos.
9. Registrant
Response
!: ! !;"" ! | . :!!; ! !; !. ": ;
??::: :-.;.,;-;.;.:,.;.,:--.,:
: I •'.. : - :-.. I : :-. -

'•:}••• •.;j,-.:;'^.'-::";

.-- : . ; -,--:---., -- ;

Date

-------
           DRAFT   COPY                            	.	Page	X of
                                           United States  Environmental  Protection  Agency
                                                            Washington,  D.  c.  20460
                                  FOOTNOTES AND  KEY  DEFIHATIONS  FOR GUIDELINE  REQUIREMENTS
                                     Case # and Name:  0024   Boric  Acid  &  its  Sodium Salts
  v- HP  = manufacturing-use product; EP = end-use product;  provided formulators purchase their active  ingredients)  fron a reaistered source, they need not submit or cite
  £ pertaining to the purchased product.INOTE: If. product U a  100 percent repackage of another  registered product  that is purchased, and any use for the product does
S differ SZ tho«TS^rch««J and registered source,  users are not subject  to any data requirements identified in the tables.]; TEP - typical end-use product;
TGAI = technical grade of  the active ingredient;  PAI = "pure"  active  ingredient; PAIRA = "pure" active ingredient,  radiolabeled.

  A ^fJJJStrfaTfood crop        8 - Terrestrial food feed crop     C - Terrestrial nonfood crop     D - Aquatic food crop           E - Aquatic nonfood outdoor
  F - Aquatic nonfood Industrial    G - Aquatic nonfood residential    H - Greenhouse food crop        1 - Greenhouse  nonfood crop     J - Forestry
  K - Residential outdoor           L - Indoor food                  H - Indoor nonfood              N - Indoor Medical              0 - Indoor residential

Footnotes:  IThe following notes are referenced in column  two  (5. Study Title) of the REQUIREMENTS STATUS AND  REGISTRANT'S RESPONSE form.]


Prod Chen -  Regular Chemical

 1  Requirements pertaining to product identity,  cc^position,  analysis, and certification of  ingredients are detailed  further in the foUowing sections:   MSB. 155 for
    Joduct  identity and coroosition <61-1>-  *15B.160, 158.162,  and 158.165 for description  of starting materials and manufacturing process <61-2>;  *1SB.167 for
    dS^±5 JlrSiSnT! I^Hties (61-3>j W.170 for pr.il.ln.ry analysis  (62-1);  *1».175  for certification of limit. (62-2); and  *1M.W  for enforcement

 2  Ansche^t!efrdiag?am(tnd/0r brief description of the production process -111 suffice if the pesticide  is not already under full scale production and  an experimental

 3  iTthTi-wstSeidTis notMready under full scale production and  an  experimental  use permit is sousht, a discussion of unintentional  ingredients shall  be submitted  to
                  srn                        produced by an integrated system or  not. the technical  grade of Active  Ingredient wt  be analyzed.   If  the technical
    graded? Active  Ingredient  cannot be isolated, /statement of composition of the practical equivalent of the technical  grade of Active  Ingredient oust be submitted.
    Data on EPs or MPs will be  required on a case-by-case basis.
  5  Certified limits are not required for inert ingredients in products proposed for experiment a I use.
 12  Required if product is potentially explosive.
 13  Required if product is a liquid.

 50  Hot required if  P™*^ reregister«d or registered under the General  Boric Acid standard issued in 1986 (i.e., product numbers from 20201-20206) or
         2) is already supported by all Product Specific Data of the Boric Acid and Boron Containing Salts  Standard ["Regular Standard") issued in 1986.
    Registrants Mith a qualifying product must review Appendix G. Attachment C and respond uith Option 8 or 9:                                ,,.,-..„       ,
           IT I n currently in compliant with the General standard and need only submit a Confidential Statement of Ferula (CSF3 and current label within 8 mos. of
     OpHnacUrrenync0eW,    the Regular Standard and need only submit the attached docunents verifying „ previous satisfactory co^etion of the
     product specific data  requirments and await  Agency requests, if needed,  for additional  documents or selection of another option.
     [ will be submitting a revised CSF and revised label  within 8 mos. of RED issuance.
 Acute Toxic - Regutar Chemical
  2  !3  SrS ;5 IS S:   : :™?«    I-  PH  less .tan 2 or g^ than 11.5; SuCh . product  y.LI be cUSSified as To,icity category ,  on the

-------
          DRAFT  COPY                                	   Page   2  of   2
                                        United states  Environmental Protection Agency
                                                        Washington,  D.  C.  20460

                                FOOTNOTES AND KEY  DEFINATIONS  FOR GUIDELINE  REQUIREMENTS

                                   Case # and Name:  0024   Boric Acid  &  its  Sodium Salts
Footnotes  (cont.):


   of potential eye and dermal  irritation effects,                                                                                       ...
 3 Required if the product consists of, or under  conditions of use Mill result in., an inhalable material (e, g., gas, volatile substances, or aerosol/parttculate).
 4 Required unless repeated dermal exposure does  not occur under conditions of use,
50 See Footnote 50 under "Prod Chem - Regular Chemical".


Efficacy - Invertebrate Control Agents

50 See Footnote 50 under "Prod Chem - Regular Chemieat".
51 Required for products claiming fire ants.
52 Required for products claiming ticks and fleas on domestic animals.
53 Required for the following products claiming control of cockroaches:
       1. All dust or bait products containing SOS active or less
       2, All dust or bait products containing greater than 0.5% Cab-o-sit M-5.
   Required for products claiming fleas on carpets.
   Required for products claiming control of "ground beetles" 
-------

-------
                         Attachment  4



             EPA Grouping of End-Dse products  for



Meeting Acute Toxicology Data Requirements for Reregistration

-------

-------
EPA'S BATCHING OP PRODUCTS CONTAINING BORIC ACID, ANHYDROUS SODIUM
TETRABORATB,  SODIUM  TETRABORATE DECAHYDRATE.  SODIUM TBTRABORATE
PENTAHTDRATE, ANHYDROUS DISODIOM OCTABORATE.  DISODIUM OCTABORATE
TETRAHYDRATE AND  SODIUM METABORATE  AS  THE ACTIVE INGREDIENTS FOR
MEETING ACUTE TOXICITY DATA REQUIREMENTS FOR REREGISTRATION

     In an  effort to  reduce the time,  resources and  number of
animals needed to fulfill  the acute  toxicity data requirements for
reregistration of products containing the active ingredients boric
acid,   anhydrous    sodium   tetraborate,    sodium   tetraborate
pentahydrate, sodium tetraborate decahydrate,  anhydrous disodium
octaborate,  disodium octaborate tetrahydrate and sodium metaborate,
the Agency has batched products  which can be considered similar in
terms  of  acute  toxicity.    Factors  considered in  the sorting
process  include  each  product's active and  inert  ingredients
(identity, percent composition  and  biological  activity), type of
formulation  (e.g.,   emulsifiable concentrate,  aerosol,  wettable
powder, granular, etc.),   and labeling  (e.g.,  signal  word,  use
classification,  precautionary  labeling,  etc.).    Note  that  the
Agency  is  not  describing  batched products  as  "substantially
similar" since some products within  a batch may not be considered
chemically similar or have identical use patterns.

     Batching has been accomplished using  the readily available
information described above,  and frequently acute toxicity data on
individual  products  has  been found to be  incomplete.   Notwith-
standing  the batching  process,   the  Agency  reserves  the right to
require, at any time, acute toxicity data for an individual product
should the need arise.

     Registrants  of  products   within  a  batch  may choose  to
cooperatively  generate,  submit  or  cite a single  battery  of six
acute  toxicological  studies  to  represent all the products within
that batch.   It  is  the registrants' option to participate in the
process  with  all  other   registrants,  only  some  of  the  other
registrants,  or only  their  own products  within a  batch,  or to
generate  all  the  required acute  toxicological  studies for each of
their own products.   If a registrant chooses to  generate the data
for a batch,  he/she  must  use one of  the products within  the batch
as  the test material.    If  a   registrant  chooses  to  rely upon
previously submitted acute toxicity  data, he/she may do so provided
that the data base is complete and valid by today's standards  (see
acceptance criteria attached) , the formulation tested is  considered
by EPA to be similar for acute  toxicity, and  the  formulation has
not been  significantly altered  since submission  and  acceptance of
the  acute  toxicity  data.    Regardless  of whether  new data is
generated or existing data is referenced, registrants must clearly
identify  the test material by EPA Registration Number.

      In   deciding  how   to   meet   the  product  specific   data
requirements,  registrants must  follow  the  directions given  in the

-------
Data Call-in Notice and  its  attachments  appended  to the RED. The
DCI Notice contains two  response  forms which, are  to be completed
and submitted to the Agency within 90 days of receipt.  The first
form,  "Data  Call-in Response," asks whether  the  registrant will
meet the  data requirements  for each product.  The second form,
"Requirements Status and Registrant's Response," lists the product
specific data required for each product,  including  the standard six
acute toxicity tests.   A registrant who wishes to participate in a
batch must decide whether he/she will provide the data  or depend on
someone  else to  do  so.    If a registrant  supplies the  data to
support  a batch of  products, he/she  must  select  one  of  the
following  options:  Developing Data  (Option  1),   Submitting  an
Existing Study  {Option 4), Upgrading an Existing Study  (Option 5)
or Citing an Existing  Study (Option 6) .  If a registrant  depends on
another's data, he/she must choose among:  Cost Sharing  (Option 2),
Offers to Cost Share (Option  3} or Citing an Existing Study  (Option
6).   If a registrant does not want to participate in a  batch, the
choices are  Options 1,   4, 5  or 6.   However, a registrant should
know that choosing not to participate in  a batch does not preclude
other  registrants in the  batch  from citing  his/her  studies and
offering to  cost  share  (Option 3)   those studies,

Table 1 displays the batches  for the active ingredients boric acid,
anhydrous  sodium tetraborate,  sodium  tetraborate  pentahydrate,
sodium  tetraborate decahydrate,  anhydrous  disodium octaborate,
disodium octaborate tetrahydrate and sodium metaborate.
Batch
1




EPA Reg. No.
239-2529
1624-117
5481-79
9444-129
9444-130
9608-2
10370-81
10370-249
43357-1
45735-1
47006-3
51311-1
64222-1
64745-3
Active Ingredient(s)
99.0% - Boric Acid
100. OX - Boric Acid
95.0% - Boric Acid
100. OX - Boric Acid
99.0% - Boric Acid
99.0% - Boric Acid
99. OX - Boric Acid
99.0% - Boric Acid
99. OX - Boric Acid
98.0% - Boric Acid
99.8X - Boric Acid
100. OX - Boric Acid
99.0% - Boric Acid
99.8X - Boric Acid
Formulation Type
Dust
Granular
Dust
Dust
Dust
Dust
Uettable Powder / Dust
Uet table Powder / Dust
Dust
Oust
Oust
Dust
Uet table Powder / Dust
Granular

-------
Batch
2









3




4
5
EPA Reg. No.
3-1
3941-17
51311-Z
54314-1
60038-2
60164-1
63992-1
64396-1
65445-1
65700- 1
10370-63
44757-3
59111-1
62962-1
66287-1
56-66
499-312
499-327
3324-7
10370-238
47362-3
50039-2
54452-2
55501-1
56667-3
57727-1
58645-1
61282-2
65445-2
475-237
4972-23
9444-131
9444-135
10370-266
Active Ingredient(s)
40. OX - Boric Acid
40,0* - Boric Acid
55. OX - Boric Acid
53.3% - Boric Acid
50.0% - Boric Acid
51.48% - Boric Acid
70. OX - Boric Acid
64.0% - Boric Acid
52.0% - Boric Acid
33.3% - Boric Acid
64.0% - Boric Acid
64. fl% - Boric Acid
64.0% - Boric Acid
65.0% - Boric Acid
65.0% - Boric Acid
51.0% - Boric Acid
50.0% - Boric Acid
50.0% - Boric Acid
40.0% - Boric Acid
51.0% - Boric Acid
51.24X - Boric Acid
51.24% - Boric Acid
33.3% - Boric Acid
47.0% - Boric Acid
51.24% - Boric Acid
50.0% - Boric Acid
45.0% - Boric Acid
51 .OS - Boric Acid
52. OX - Boric Acid
2.0% - Boric Acid
6.0% - Boric Acid
5.0% • Boric Acid
5.0% - Boric Acid
5.0% - Boric Acid
Formulation Type
Tablet
Tablet
Bait
Bait
Tablet
Dust
Bait
Dust
Bait
Bait
Dust
Uet table Ponder / Dust
Wet table Powder / Dust
Dust
Dust
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Liquid / Bait
Bait
Bait
Bait
Bait
Bait

-------
Batch
5 (cont'd)

6








7
8
9
EPA Reg. No.
56667-4
64405-2
1624-11
1624-39
1625-125
9444-132
19713-286
44313-19
54089-1
63442-1
64820-1
65382-2
65705-1
66480-2
64405-1
64405*3
64405-4
B02-352
7001-292
7001-337
802-563
7001-341
Active lngr«dient(s)
5.0% • Boric Acid
5.0% - Boric Acid
98. OX - Disodium
Octaborate Tetrahydrate
98.0% - Disodium
Octaborate Tetrahydrate
98. OX - Disodium
Octaborate Tetrahydrate
98. OX - Disodiun
Octaborate Tetrahydrate
98.0% * Di sodium
Octaborate Tetrahydrate
98.0% - Disodiun
Octaborate Tetrahydrate
99.4% - Disodium
Octaborate Tetrahydrate
98. OX - Disodiun
Octaborate Tetrahydrate
98.0% - Disodium
Octaborate Tetrahydrate
98.0% - Disodiun
Octaborate Tetrahydrate
98. OX - Disodiun
Octaborate Tetrahydrate
98.0% - Disodium
Octaborate Tetrahydrate
40.0% - Disodium
Octaborate Tetrahydrate
40.0% - Disodium
Octaborate Tetrahydrate
40. OX - Disodium
Octaborate Tetrahydrate
66.5* - Sodiun
M elaborate Tetrahydrate
66. SX - Sodium
Hetaborate Tetrahydrate
66.5X - Sodium
Hetaborate Tetrahydrate
68. OX - Sodium
Hetaborate Tetrahydrate
68.0% - Sodiun
Hetaborate Tetrahydrate
Formulation Type
Bait
Bait
Soluble Concentrate / Solid I
Soluble Concentrate / Solid
Solid

Soluble Concentrate / Solid
Solid
Soluble Concentrate
Soluble Concentrate
Soluble Concentrate / Solid
Uettable Powder
Soluble Concentrate
Soluble Concentrate
Soluble Concentrate
Solution
Ready-To-Use Solution
Granular
Uettable Powder / Dust
Uettable Powder / Dust
Granular
Wet table Powder / Dust

-------
Batch
9 (cont'd)
10
11

12
13
14
15
16
EPA Reg. No.
10827-58
1421-151
1769-82
5905-165
5906-166
9754-7
11440-3
7001-339
7413-3
7001-345
9754-1
1624-1
51708-11
64745-1
1624-94
9444-134
64745 -2
Active Ingredient(s)
68.0% - Sodium
Hetaborate Tetrahydrate
6% - Sodium Ketaborate
18% - Sodium Chlorate
9% Sodium Metabcrate
18% sodium Chlorate
53.84% - Sodiun
Hetaborate Tetrahydrate
41.04% - Sodiun Chlorate
4.22% - Bromacil
55.47% - Sodium
Hetaborate Tetrahydrate
41.07% - Sodiun Chlorate
4.22% - BromaciL
19.1% - Sodiun
Ketaborate Octaborate
1S.1 - Sodiun Chlorate
19. 1% - Sodiun
Metaborate Octaborate
18.1 - Sodiun Chlorate
66.5% - Sodiun
Metaborate Tetrahydrate
30.0% - Sodium Chlorate
1.5% - BromaciL
66.5% - Sodiun
Hetaborate Tetrahydrate
3D. OX - Sodiun Chlorate
1.5% - BromaciL
8.75% - Sodium
Hetaborate Anhydrous
10.3% - Sodiun Chlorate
0.41% - Bromacil
10% - Sodium Hetaborate
Anhydrous
7.0% - Sodiun Chlorate
0.3% - BromaciL
100% - sodium
Tetraborate Pentahydrate
100% - Sodiun
Tetraborate Pentahydrate
100% - Sodium
Tetraborate Pentahydrate
100% - Sodium
Tetraborate Decahydrate
100% - Sodiun
Tetraborate Decahydrate
100% - Sodiun
Tetraborate Decahydrate
Formulation Type
WettabLe Powder / Dust
Soluble Concentrate
Soluble Concentrate
Tablet
Tablet
Soluble Concentrate
Soluble Concentrate
Wettable Pouder / Dust
Dust
Soluble Concentrate
Soluble Concentrate
Granular
Granular
Granular
Crystalline
Dust
Soluble Concentrate / Solid

-------
Batch
16 (cont'd)
17
18
EPA Reg. Ha.
65161-1
66674-1
149-8
3095-47
8383-1
8383-3
8383- 7
Active Ingredient(s)
100% - Sodium
Tetraborate Decahydrate
100S - Sodium
Tetraborate Decahydrate
5.4% - Sodium
Tetraborate Decahydrate
5X - sodium Tetraborate
Decahydrate
0.47% - sodium
Tetraborate
1.41% * Phenol
0.24% - Sodium Phenate
0.47% - Sodium
Tetraborate
1.41% - Phenol
0.24% - Sodium Phenate
0.47% - Sodium
Tetraborate
1.41X - Phenol
0.24% - Sodium Phenate
Formulation Type
Dust
Wettable Powder / Dust
Bait / Liquid
Beit / Liquid
Ready- To- Use Solution
Ready-To-Use Solution
Towelette
Table 2 lists  chose products the Agency was unable to batch.  These
products were  either considered not to be similar  to other products
for purposes  of  acute toxicity  or the Agency lacked sufficient
information for decision making.    Registrants of these products
are responsible for meeting the  acute toxicity data requirements
for each product.

Table 2.
Urtoatched Boric Acid, Artiydrous Sodium Tetraborate, Sodium Tetraborate
Pentahydrate, Sodium Tetraborate Decahydrate, Anhydrous Disodium Octaborate,
Disodiur Octaborate Tetrahydrate and Sodium Hetaborate.
EPA Res. Ho.
100-479
499-220
690-48
1022-536
1083-1
Active
Ingredients
Sodium Hetaborate 	 50. OX

Preweton 	 	 5.0%

Boric Acid 	 20. OX
Sodium Hetaborate 	 49.0%
Sodium Chlorate 	 	 48. OS
Sodium Tetraborate
Decahydrate 	 40. OSS
Copper Naphthenate 	 18.16%
Borax 	 	 0. 28%

Formulation Type
Pellet / Tablet
Pressurized Dust
Granular
Ready- To* Use Solution
Emulsif iable Concentrate

-------
Unmatched Products (continued)
EPA Reg. Ho.
1624-3
2869-15
3095-24
4236-8
5887-46
7001-540
7701-34
8020-1
9444-133
10356-16
18910-6
19713-204
19713-206
33436-1
33560-43
44757-4
46196-1
48211-73
49168-1
59977-1
Active Ingredient(s)
Sodium Tetraborate ..
Sodium Hetaborate
Tetrahydrate 	 	
Sodium Chlorate 	
Ortho Boric Acid ....
Sodium Tetraborate
Sodium Hetaborate
(anhydrous) 	 .

Sodium Hetaborate ..
Sodium Chloride 	
Sodium Hetaborate
Tetrahydrate 	 	

Sodium Berate 	 	
Sodium Chlorate 	
Boric Acid 	
Boric Acid 	
Disodium Octaborate,
Boric Acid 	

Sod inn Chlorate 	
Bromaeil 	
Sod fun Tetraborate
Pentshydrate ........
Sod inn Chlorate 	
Bromaeil 	
Boric Acid ..........
Calcium sulfate,
Di hydrate ...........
Aluminun Sulfate,
Sodium Hetaborate ...
Sodium Chlorate 	


Boric Acid 	

Sodium Hetaborate
Tetrahydrate 	
Sodiun Chlorate .....



..100.0%
. 4.57%
. 3.11%
. 4.0%
. 5.0%
. 10.0%
. 7.0%
10 1%
. 18.5*
. 94.0%
. 4.0%
. 11.41%
. 22.14%
.. 90.0%
.. 20.0%
..100.0%
.. 63.2%
. . 50.0%
. . 40.0%
.. 8.0%
. . 38.8%
.. 58.0%
.. 2.5%
.. 0.9%
.. 74.0%
,. 15.9%
. . 50.0%
. . 40.0%
. . 2.0%
. . 2.0%
.. 14.72%
.. 63.5%
.. 66.5%
.. 30.0%
.. 1.5X
.. 74. 0*
.. 18.0%
formulation Type
Granular
Soluble Concentrate
Bait
Ready-To-Use Solution
Soluble Concentrate
Soluble Concentrate
Soluble Concentrate
Dust
Pressurized Liquid
Solid Rods
Ready- To-Use Solution
Granular
Pellet / Tablet
Soluble Concentrate /
Solid
Pellet / Tablet
Impregnated Material
Dust
Granular
Dust
Granular

-------
Unbatched Products
EPA Reg. Ho.
62190-9
AL92000300
AL92000400
{continued)
Active ingredients
Boric Acid ............

Sodium Tetraborate
Boric Acid 	
Sodi un BorBte ..........
Didecyl Dimethyl AnmonU
26.3%
4.0%
2.0%
2.0%
in
2.0%
Formulation Type
Soluble Concentrate /
Solid
Ready-Ta-Use Solution
Ready-To-Use solution

-------
     Attachment  5




EPA Acceptance Criteria

-------

-------
                          SUBDIVISION D
Guideline      Study Title

Series 61      Product Identity and Composition
Series 62      Analysis and Certification of Product Ingredients
Series 63      Physical and Chemical Characteristics

-------

-------
                                  61 Product Identity and Composition
ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?

1.	   Name of technical material tested (include product name and trade name, if appropriate).

2.	   Name, nominal concentration, and certified limits (upper and lower) for each active ingredient and each
          intentionally-added inert ingredient.

3.	   Name and upper certified limit for each impurity or each group of impurities present at ^ 0.1% by
          weight and for certain toxicologically  significant impurities (e.g.,  dioxins, nitrosamines) present  at
           <0.1%.

4.	   Purpose of each active ingredient and each intentionally-added inert.

5.	   Chemical name from Chemical Abstracts index of Nomenclature and Chemical Abstracts Service (CAS)
          Registry Number for each active ingredient and, if available, for each intentionally-added inert.

6.	   Molecular, structural, and empirical formulas, molecular weight or  weight range, and any company
          assigned experimental or internal code numbers for each active ingredient,

7.	   Description of each beginning material in the manufacturing process.
          	 EPA Registration Number if registered; for other beginning materials,       the     following:

          	 Name and address of manufacturer or supplier,
          	 Brand name, trade name or commercial designation.
          	 Technical specifications or data sheets by which manufacturer or supplier describes composition,
                properties or toxicity.

8.	Description of manufacturing process.
          	 Statement of whether batch or continuous process.
          	 Relative amounts of beginning materials and order in which they are added.
          	 Description of equipment.
          	 Description of physical conditions (temperature, pressure, humidity) controlled in each step and
                the parameters that are maintained.
          	 Statement of whether process involves intended chemical reactions.
          	 Flow chart with chemical equations for each intended chemical reaction.
          	 Duration of each step of process.
          	 Description of purification procedures.
          	 Description of measures taken to assure quality of final product.

9.	   Discussion of formation of impurities based on established chemical theory addressing (1) each impurity
          which may be  present at  >_ 0.1% or  was found at  >_ 0.1% by  product  analyses and (2) certain
          toxicologically significant impurities (see #3).

-------
                          62 Analysis and Certification of Product Ingredients
                                       ACCEPTANCE CRITERIA

The following criteria apply to the technical grade of the active ingredient being reregistered. Use a table to present
the information in items 6, 7, and 8.

Does your study meet the following acceptance criteria?

 1.      Five or more representative samples (batches in case of batch process) analyzed for each active ingredient
         and all impurities present at >_ 0.1 %.
 2.	  Degree of accountability or closure _>. ca 98%.
 3.	  Analyses conducted for certain trace toxic impurities at lower than 0.1% (examples, nitrosamines in the
         case of products containing dinitroanilines or containing secondary or tertiary amines/alkanolamines plus
         nitrites; polyhalogenated dibenzodioxins and dibenzofurans). [Note that in the case of nitrosamines both
         fresh and stored samples must be analyzed.].
 4.	  Complete and detailed description of each step in analytical method used to analyze above samples.
 5.	  Statement of precision and accuracy of analytical method used to analyze above samples.
 6.	  Identities and quantities (including mean and standard deviation) provided for each analyzed ingredient.
 7.	  Upper and  lower certified limits proposed for each active ingredient and intentionally added inert along
         with explanation of how the limits were determined.
 8.	  Upper certified limit  proposed for each  impurity  present at >_ 0.1% and for certain lexicologically
         significant  impurities  at <0.1% along with explanation of how limit determined.
 9.      Analytical  methods to verify certified Limits of each active ingredient and impurities (latter not required
         if exempt from requirement of tolerance or if generally recognized as safe by FDA) are rally described.
10.	  Analytical  methods (as discussed in #9) to verify certified limits validated as to their precision and
         accuracy.

-------
                                63 Physical and Chemical Characteristics

                                       ACCEPTANCE CRITERIA


The following criteria apply to the technical grade of the active ingredient being reregistered.

Does your study meet the following acceptance criteria?

63-2 Color
    	  Verbal description of coloration (or lack of it)
    	  Any intentional coloration also reported in terms of Munsell color system
63-3 Physical State
    _  Verbal description of physical state provided using terms such as "solid, granular, volatile liquid"
    _  Based on visual inspection at about 20-25° C

     Odor
          Verbal description of odor (or lack of it) using terms such as "garlic-like, characteristic of aromatic
          compounds"
          Observed at room temperature
63-5 Melting Point
    _  Reported in °C
    _  Any observed decomposition reported

63-6 Boiling Point
    _  Reported in "C
    _____  Pressure under which B.P. measured reported
    _  Any observed decomposition reported

63-7 Density, Bulk Density, Specific Gravity
    _  Measured at about 20-25' C
    _  Density of technical grade active ingredient reported in g/ml or the specific gravity of liquids reported
          with reference to water at 20° C. [Note: Bulk density of registered products may be reported in lbs/ft3
          or Ibs/gallon.]

63-8 Solubility
    _  Determined in distilled water and representative polar and non-polar solvents, including those used in
          formulations and analytical methods for the pesticide
    _  Measured at about 20-25° C
    _  Reported in g/100 ml (other units like ppm acceptable if sparingly soluble)

63-9 Vapor  Pressure
    _  Measured at 25° C (or calculated by extrapolation from measurements made at higher temperature if
          pressure too low to measure ai 25° C)
    _  Experimental procedure described
    _  Reported in mm Hg (torr) or other conventional units

63-10 Dissociation Constant
    _  Experimental method described
    _  Temperature of measurement specified (preferably about
          20-25 °C)

-------
63-11 Octanol/water Partition Coefficient
    	   Measured at about 20-25° C
    	   Experimentally determined and description of procedure provided (preferred method-45 Fed. Register
           77350)
    	   Data supporting reported value provided

63-12 pH
    	   Measured at about 20-25° C
    	   Measured following dilution or dispersion in distilled water

63-13 Stability
    	   Sensitivity to metal ions and metal determined
    	   Stability at normal and elevated temperatures
    ___   Sensitivity to sunlight determined

-------
                          STJBDZVTSION F
Guideline              Study Title

  81-1         Acute Oral Toxicity in the Rat
  81-2         Acute Dermal Toxicity in the Rat, Rabbit or Guinea
               Pig
  81-3         Acute Inhalation Toxicity in the Rat
  81-4         Primary Eye Irritation in the Rabbit
  81-5         Primary Dermal Irritation Study
  81-6         Dermal Sensitization in the Guinea Pig

-------

-------
                                  81-1  Acute Oral Toxicitj  in the Rat
                                       ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
 1.	Identify material tested (technical, end-use product, etc).
 2.	At least 5 young adult rats/sex/group.
 3.	Dosing, single oral may be administered over 24 hrs.
 4."	Vehicle control if other than water.
 5.	Doses tested, sufficient to determine a toxicity category or a limit dose (5000 mg/kg).
 6.	Individual observations at least once a day.
 7.	Observation period to last at least 14 days, or until all test animals appear normal whichever is longer.
 8.	Individual daily observations.
 9.	Individual body weights,
10.	Gross necropsy on all animals.
                    Criteria marked with an * are supplemental and may not be required for every study.

-------
                      81-2  Acute Dermal toxicity in the Rat, Rabbit or Guinea Pig


                                       ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
 1.	Identify material tested (technical, end-use product, etc).
 2.	At least 5 animals/sex/group.
 3.*	Rats 200-300 gm, rabbits 2.0-3,0 kg or guinea pigs 350-450 gm,
 4.	Dosing, single dermal.
 5.	Dosing duration at least 24 hours.
 6.*	Vehicle control, only if toxicity of vehicle is unknown.
 7.	Doses tested, sufficient to determine a toxicity category  or a limit dose (2000 rag/kg).
 8.	Application site clipped or shaved at least 24 hours before dosing.
 9.       Application site at least 10% of body surface area.
10.	Application site covered with a porous nonirritating cover to retain test material and to prevent
        ingestion.
11.	Individual observations at least once a day.
12.	 Observation period to last at least 14 days.
13.	Individual body weights.
14.	Gross  necropsy on all animals.
                     Criteria marked with an * are supplemental and may not be required for every study.

-------
                                81-3 Acute Inhalation Toxicity in the Rat


                                       ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?

 1,	Identify material tested (technical, end-use product, etc).
 2.	Product is a gas, a solid which may produce a significant vapor hazard based on toxicity and expected use
        or contains particles of inhalable size for man (aerodynamic diameter  15 fira or less).
 3.	At least 5 young adult rats/sex/group,
 4.	Dosing, at least 4 hours by inhalation.
 5.	Chamber air flow dynamic, at least 10 air changes/hour, at least 19% oxygen content.
 6.	Chamber temperature, 22° C  (+2°), relative humidity 40-60%.
 7.	Monitor rate of air flow.
 8.	Monitor actual concentrations of test  material in breathing zone.
 9.	Monitor aerodynamic particle size for aerosols.
10.	  Doses tested, sufficient to determine  a toxicity category or a limit dose (5 mg/L actual concentration of
        respirable substance).
11.	  Individual observations at least once a day.
12.	  Observation period to last at least 14  days.
13.	  Individual body weights.
14.	  Gross necropsy  on all animals.

-------
                                81-4 Primary Eye Irritation in the Rabbit


                                       ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?

 1.	Identify material tested (technical, end-use product, etc).
 2.	Study not required if material is corrosive, causes severe
        dermal irritation or has a pH of <2 or > 11.5.
 3.	6 adult rabbits.
 4.	Dosing, instillation into the conjunctival  sac of one eye
        per animal.
 5.	Dose, 0.1 ml if a liquid; 0.1 ml or not more than 100 mg if a solid, paste or paniculate substance.
 6.	Solid or granular test material ground to  a fine  dust.
 7.	Eyes not washed for at least 24 hours.
 8.	Eyes examined and graded for irritation before  dosing and
        at 1, 24, 48 and 72 hr, then daily until eyes are normal
        or 21 days (whichever is shorter).
 9.*	Individual daily observations.
                     Criteria marked with an * are supplemental and may not be required for every study.

-------
                                 81-5  Primary Dermal Irritation Study

                                       ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?

 1.	Identify material tested (technical, end-use product, etc).
 2.	Study not required if material is corrosive or has a pH of <2 or j>_U.5.
 3.	6 adult animals.
 4.	Dosing, single dermal.
 5.	Dosing duration 4 hours.
 6,	Application site shaved or clipped at least 24 hours prior to dosing.
 7.	Application site approximately 6 cm:.
 8.	Application site covered with a gauze patch held in place widi nonirritating tape.
 9,_	 Material removed, washed with water, without trauma to application site.
10.	  Application site examined and graded for irritation at 1,  24, 48 and 72 hr, then daily until normal or 14
        days (whichever is shorter).
11.*	  Individual daily observations.
                    Criteria marked with an * are supplemental and may not be required for «v«iy study.

-------
                              81-6  Dermal Sensitization in the Guinea Pig

                                       ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?

1.	Identify material tested (technical, end-use product, etc).
2.    Study not required if material is corrosive or has a
      pHof j<2 or Ml.5.
3.	 One of the following methods is utilized:
      _____ Freund's complete adjuvant test
      	Guinea pig maximization test
      	Split adjuvant technique
      	Buehler test
      	Open epicutaneous test
      	Mauer optimization test
      	Footpad technique in guinea pig.
4.	Complete description of test.
5.*	Reference for test.
6.	 Test followed essentially as  described in reference document.
7.	 Positive control included (may provide historical data conducted within the last 6 months).
                     Criteria marked with an * are supplemental and may not be required for every study.

-------
              Attachment  6



List of Registrants Receiving this Notice

-------

-------
                                  List  of  All  Registrants Sent  This  Data Call-Iri Notice
       and Hajng
 0024   Boric Acid
 Ch«miaal f and Nuns
 011001    Boric acid
 Company dumber  Company Kama
                                                    Additional Kama
                                                                                       Address
                                                                                                                           City  & State
                                                                                                                                                          Zip
 000003
 OOOO5S
 000099
 000239
 000475
 000499
 000655
 000769
 000869
 0014TS
 001621
 003095
 003282
 003324
 003487
 004972
 005130
 005481
 006020
 008660
 003346
 0090B6
 009444
 009608
 010039
010088
010370
011474
018910
019713
034797
E.F.  HARRIS MFG. CO., INC,
SATON JT  & COMPANY MC
WATKINS INCORPORATED
SOLARIS GROUP, TEE
RECK I IT I C01EMBM HOUSEHOLD PRODUC
HKITMIRE  RESEARCH LABORATORIES, IN
FRENTIS3  IHC
H . R .  MCLANE,  IMC .
GREEN LIGHT COMPANY
LAND IS 1NTERNATIOBAL, IKC,
U.S.  BORAX IMC
PIC COW
D-CON COMPANY INC
GENERAL PB3T  SERVICE CO
BACON PRODUCTS COMPANY IMC
PROTEXAL3, PRODUCTS INC
BEGWEST CO
JMVAC CHEMICAL CORP
BEST  ENTERPRISES LTD
AHDERSONS, (IKS}, MWK FERTILIZER
SAFEGUARD CHEMICAL CORP
ROXIDE INTERNATIONAL IHC
HATEFBURY COMPANIES INC
COPPEK BR1TE, IHC.
RAGO  PRODUCTS INC.
WHHA LABORATORIES IHC
ROU3SEL UCLAF CORP
SUNCRO CHEMICALS, INC.
DESOHAG MATERIALSCHUTZ OffiH
DREXEL CHEMICAL CO
QUW.IS INC
A DIV OF THE AC DIV OF MOM3ANTO CO
AGENT FOR: SCTRECO,  IHC.
AGENT FOR: WIL1ERT HOME PRODUCT3
ACEHT FOR!  JOHNSON CHEMICAL CO, IN
AGENT FOR)  ANDERSONS, THE
flOLVAIT SECHHOLOCIES, INC.
BOX 7344
1393 E. HIGHLAND ROAD
150 LIBERTY ST
BOX 5008
1655 VALLEY RD
3568 TREE CT IHDUSTRIAL BLVD
C. B. 2000
7210 RED ROAD,  SUITE 206
P.O. BOX 17985
3025 MADISON HWY BOX 5126
BOX 926
23 3 ESSEX flVE
225 SUWIIT HVENUE
1819 OOLDFIELD STREET tB
BOX 22187
1109-11 HWI 427 H.
BOX 2220
4100 EAST WASHIHCTOM BIVD
BOX 946
BOX 119
306 E.  144 ST.
BOX 249
BOX 610
BOX 50610
657 CRESCENT AVB
P.O. BOX 23926
95 CHESTNUT RIDGE RD
P. O. BOX 24632
500 FIFTH AVE SUITE  3000
BOX 9306
4600 PARK AVE
 JACKSONVILLE FL
 THIH3BUP.G OH
 HIHOHA MB
 SAH RAMOK CA
 WAYNE HJ
 ST LOUIS HO
 FLOHA1, PARK NY
 MIAMI FL
 SAN ANTONIO TX
 VALDOSTA GA
 VALENCIA CA
 ORANGE NJ
 MONTVALE NJ
 NORTH LAS VEGAS HV
 CHATTANOOGA TN
 LONGWOOD FL
 CREELBI CO
 LOS ANGELES CA
 HINTERVILLE HC
 MADMEE OH
 BRONX NY
 NEW ROCHEL1E HY
 INDEPENDENCE LA
 SANTA BARBARA CA
 BRONX NY
MILWAUKEE HI
MONTVALE HJ
 LOS AN'SELES CA
HEW YORK NY
MEMPHIS TN
DBS K01HE.S IA
3223S
44087
5S987
94S83
O7474
63122
11002
33143
79217
30603
91380
07050
0764S
89030
37422
32750
BOC32
90023
2S590
43537
10454
10802
70443
93150
10458
53223
07645
9O024
10110
38109
S0321

-------
                                  List  of All Registrants  Sent  This  Data  Call-in  Motice
Cue f and Name
0024    Boric  Acid
Chuicml t and Hams
011001   Boric  acid
Coupany NmabeF   Company Name
                                                   Additional Hamo
                                                                                       Address
                                                                                                                          City 1 State
                                                                                                                                                         Zip
035488
0-10849
043357
043512
044405
044632
0447S7
045385
045735
046196
047006
047362
048005
049585
050039
051311
051463
051793
053114
053651
054089
054314
054452
OS4700
055501
055540
056667
056982
057445
057727
058645
J.M.W.  ASP S  COMPANY,  INC.
REGWEST CO
GERALD G. MCCARTHY
J.  C.  CHEHICA1 00.
NU-HAY PRODUCTS
CHEM PRODUCTS CO
IN-CIDE TECHNOIiOCJIES,  INC.
CTX IMC
BURtltKHON SCIENTIFIC CORPORMIOW
T.W.O.  INC.
UNICORN LABS  AMD PKAETOH COM
LftNDXS INTERNATIONAL IMC
ROACHPROOF1NG ASSOCIATES, IMC.
PESTICIDE BEGVUITORY SERVICES
HHEELUS SERVICES, INC
TAMBY CHEMICAl INC.
REGHEST CO
RSR LABORATORIES, INC
MAGNAGAFD,  IMC
ROSE i CO,
R VALUE/TOST
MARIA V. THORNHILL
BLUE DIAMOND EXTEBMIHATIHG C MP3,
JERRI-LEIGH  ENTERPRISES
EARTH FRIBHDI.X PRODUCTS IMC
MULL IS ENTERPRISE
J. HOODALL  S ASSOCIATES, INC
A J AMERICA CO.  IHC.
ALEXANDER ENTERPRISES
LAND IS  INTERNATIONAL IHC
ROACH X-ODOS
AGENT FOR:  ENFORCER PRODUCTS INC
AGENT FOR: SEABF.ICHT ENTERPRISES L
AGENT FOR: ALLJACK & CO.
ASENT FOR: AMERICAN HOUSEHOLD PROD
 AGEHT TOR: BUDDIES PUDDY CO
 MARGARET K. DEHETRG EHTERPRISBa
330 CLUB DRIVE
BOX 2220
900 MAIN ST
1725 SO. HARVARD BLVD.
5927 S.  WESTERN AVE.
1120 CHALLEDOH BD
SO H. 41 AVENUE, SUITE f2
481 SCOTLAND RD
22Z SHEaWOOD AVGHUE
719 GALLOHftY CT
1000 113TH AVE H
BOX 5126
P.O. BOX 9293
3703 SEDCEFIELD DR
1360 HEW HOPE RD
214 51ST STREET
BOX 222O
501 FIFTH SI
1718 DIETRICH BE
BOX 681 14 EMI1Y  RD.
150 H SANTA ANITA AVE,  f3CO
11705 LONOLEAT
ROUtB 2 BOX 1322
ROUTE 1 BOX 4SO
BOX 47
RT *1
BOX 415
1338 RIFLE RANGE RD.
2958 RAINBOW DRIVE, SUITE 21S
BOX  5126
9602 HIGHMEADOH
C ASTON I A BC
GREELEY CO
MASS EH A I A
LOS ANGEIE9  CA
CHICAGO IL
GREAT FSX13  VA
PHOENIX AZ
MCHENRY IL
WIHTER SPRINGS Fl
ST. PETERSBURG PL
VA1DOSTA CA
CORAL SPRINGS Ft
VALD09TA SA
IAHRENCEVILIB GA
BROOBCLYK HV
GFBELEY CO
BRISTOL TN
roRISTELL MO
BROAD BROOK CT
ARCADIA CA
HOUSTON TX
FOCERSVILLE TN
KEE3EE SC
SLOCOMB At
CADHELL GA
GRAXSOH OA
EL CERKITO CA
DECATUR '3A
VALDO3TA GA
HOUSTON TX
28051
80632
5O853
90006
60636
2206C
85C09
60050
1113S
32709
33716
31603
33075
31602
30245
11220
B0632
37620
63348
06016
91006
77024
37857
29107
36375
31009
30221
94530
30034
31603
77063

-------
                                  List  of All  Regiatrants  Sent  This  Data Call-in notice
Ca*» f and Noms
0024    Boric Acid
Chemical f and Name
011001   Boric  acid
Company Numbejr  Company Name
                                                    Additional Nema
                                                                                                           City S Stats
                                                                                                      2±p
059111
059177
059504
059977
060038
061282
062190
062577
O62962
063992
064396
064405
0(1745
065145
065445
065505
06SS27
065700
OE5754
0«59OC
0««4BO
066674
066680
066746
066764
066791
066986
RX KOR  FLEAS, INC
ENTRE MARKETIHO £ SALES,  INC.
SAP ROACH POWDER
BUSHWHACKER ASSOCIATES IHC, THE
CLEVELAND J. BREAUX, SB.
HACCO,  IMC.
KICKSON CORPORATION
KITTRICH CORPORATION
ECOTECH
LAND IS  INTERNATIONAL IHC
BIO NATURAL IHG
RESHEST CO
NORTH AMERICAN CHEMICAL CO
DEYPSEY-FITZ CORP
10 TOX  PRODUCTS INTERNATIONAL INC
ROACH BID INC
FLEA STOPPERS INTERNATIONAL IHC.
WACO CHEMICAL MTG. CO IHC.
ENVIRONMENTAL COATINGS IHC
JOHBS,  CORK « MILLER
BENJAMIN E ROGERS
JOHN M. KENNEDY CONSULTMWS
CANINE  CARE INC
CftRE-FLEA ONE TEAR OUBRAWIEE CO
HATIOHA1 FEATURES SYNDICATE
JOHN MARSHALL
BUG HOU3B tRSI CONTROL
PARAS ITIK CORP
DIVISION OF BETHURUH RESEARCH « DE
DBA
AGEHT FOR:  TMJISftKE CO I,TD
AGENT FOR:  NISUS CORP
                                                    AGENT FOR: ROACH BUSTERS IHC
                                                    AGENT FOR: ECO-FRESH INDUSTRIES IN
6555 Nil 9TH AVE SUITE «12
16 4 3 TERRACE
5920 HILSHIRE BLVD., SUITE 503
BOX 3456
1703 JUANITA ST  .
537 ATLAS AVE
3941 BOKSAL RD
4500 DISTRICT BOULEVARD
143 MH 16TH ST
BOX 5126
1751 BAHIA VISTA ST
BOX 2220
8300 COLLEGE BLVD
108 1/2 PO3TOAK RD  (N)
200 SOUTH 14TH AVE
9528-35 MIRftMAH BD
32OB OLD CHARLOTTE HWY
BOX 389
BOX 2068
BOX 6437
8301 HRENS WAY
9101 CHERRY LANS
BOX 11436
114 STAMDriEUi
2359 JEFFERSON DR S.E.
25601 HARBOHHE AVE
1776 NORTH JEFrERSOH ST - STE A
49SO CARROLL CANYON RD
FORT LAUDEKDAIE FL
MT VEEtttOK HT
LOS ANGELES CA
SALVBSTOK TX
HEW IBERIA LA
MADISON HI
CONLEY GA
LOS ANQEIE3 OR
BOCA RMOW FIi
VALDOSTA CA
SARASOTA FL
SREELE7 CO
OUERLAWD FARE KS
SULPHUR LA
MT VERNON NY
SAN DIEGO CA
MONROE NC
HYDEN KY
DOTHAtl AL
MAOOH GR
LARGO FL
LAUREL MD
COSTA MESA CA
MESWITE TX
ORAKD RAPID9 Ml
LOMITA CA
MILLEDGEVILLE CA
SAN DIEGO CA
33309
10550
90036
77S52
70560
53716
30027
90058
33432
31603
34239
B0632
66210
70664
10550
92126
28110
41749
36302
31208
34643
20708
92627
75181
49507
90717
31061
92121

-------
Ca» 4 and Nona
0024 Boric Acid
Chattical f and Hams
011102 Borax {B4Na207. 10H20) (1303-96-4)
Company Ntunbar Company Nome Additional Hams Addraaa
000149 SEHORET CHEMICAL COMPANY, INC. 566 LEFFIHCWELL AVE
001022 IBC MANUFACTURING OO *16 BROOK3 RD
001624 U.S. BORAX 1HC Box 926
002935 WILBUR ELLIS CO. 191- H SHAW AVE
003095 PIC 008P 23 S ESSEX AVE
008383 3PORICIDIH nTTERNftllOHH, 3901 MOHTR03E RD
009444 HATERBTOT COWPAHIES INC Box 6*°
04219B BEGKEST CO RGEMT FORl HATIOHM. RESEARCH fi CHE BOX 2220
064745 NORTH WffiRICJVK CHEMICAL CO S3°° COLLEGE BLTO
065161 FLEAGO 1HDUSTRIES 44* PI™ AVE
06S7S4 ENVIROHMEHTAI, OOATIKGS IHC ^°x Z06e
066674 CANINE CARE IKC Box 11*3*
City S State Zip
KIEKHOOD MO 63122
MEMPHIS TN 38109
VALEKCIR CA 91380
FRESNO CA 93704
ORAtKM MJ OTOSO
ROCKVIKLE MD 20852
tMDEPGHDEHCE LA 70443
CREELEY CO BO 53 2
OVERLAND PAKE K3 €6210
NftPLES FI, 33963
IXJTKAM Al 36302
COSTA MESA CA 92627

-------
                             List of All  Registrants  Sent  This Data Call-in Notice
Casa t and Name
Chania*! | and Mama
011110   Boron sodium oxide  
-------
                            List  of All Registrants Sent  This  Data Call-in Notice
Caoa f and. Nona
Chemical i and Nona
011112   Boron  sodium  oxide  (B4Na207)    (1330-43-4)
Conpany Nunbar   Company
                                           Additional Horn
                                                                         Addcass
                                                                                                       City £ Stat»
                                                                                                                                 Hip
001083
001624
003095
007701
CED-O-PROWJCTS CORP
U.S. BORAX INC
PIC COUP
CHEMICAL SPECIALTIES THC
903 ALLEN ROAD
BOX 926
23 S ESSEX AVE
149 WEST TEtlOC AVENUE
NORKI SYRACUSE NY
VALENCIA CA
ORANGE MJ
MEMPHIS TK
13212
91360
07050
3S10S

-------
                                List  of All Registrants  Sent  This Data  Call-In  Notice
Caa« i and Home
0024   Boric  Acid
Chemical t "IK* Hans
011103   Boron  sodium oxide  (B8Na2013),  tetrahydrate   {1228
Conpony Number  Company Name
                                                Additional None
                                                                                 Addraas
                                                                                                                  City i State
                                                                                                                                                Zip
001624
003008
009444
019713
035053
040849
044313
044757
054089
063442
064405
064820
065382
065705
066144
0664BO
U.S.  BORAX INC
OSMOSE WOOD PRESERVING:, INC
WATERBURY COMPANIES IHC
DREXE1 CHEMICAL CO
HONOLULU WOOD THEATIHS CO
REGHEST CO
R VALUE INC
IS-CIDE TECHNOLOGIES, IHC.
R VALUE/WEST
FIVE  POINTS INC.
KEGWEST CO
REOWEST CO
FLEAXPEJ.TS IHC
ENVIROTECH V£NTUR£3 IHTEEtNATIONAI.
P1EAXPEP.TS IHC
JOHN  W. KENHEDY
AGENT FOR: ENFORCER PRODUCTS IHC
AGENT FOR: NISUS CORP
AGENT FOR.: 3A3HCO
                                                AGENT: FOR; BCO-FRESH INDUSTRIES IN
BOX 926
980 EL1ICOTT ST
BOX £40
BOX 9306
91-291 KANUA STREET
BOX 2220
5421 CRESTWOOD DR
50 N. 41 AVENUEr SUITE f2
150 II SANTA ANITA AVE,  f30D
RDtl BOX 12 EODUM PJ)
BOX 2220
BOX 2220
8993 COMPLEX DR
504 R E CORNWJLLLIS DR BOX  13088
9993 COMPLEX DR
9101 CHERRY LAME
VALENCIA CA
BUFFALO NY
INDEPENDENCE LA
MEMPHIS TN    :
EWfi BEACH HI
GREELE^ CO
KNOXVILLE TM
PHOENIX AS
ARORDIA CA
LITTLE VALLEX ITT
GREELET CO
GREELEY CO
SAN DIE3C CA
GREENSBORO HC
SAN DIEGO CA
LAUREL MD
91330
14209
70443
38109
9S707
S063Z
37914
S5009
91006
14755
30632
QOC32
92123
27415
92123
2O703

-------
                          List  of  All  Registrants  Sent  This Data Gall-ln Motice
    4 and
Chemical # and Najuo
011107   Boron sodium  oxide (B8Na2013)    (12008-41-2)
Company Number  Company Mama
                                        Additional Name                Addrass                       City 5 Stata               Bip
01035«        CHEMICAL SPECIALTIES, IHC.                                   OME WOODLAHN GREEN              CHWU.OTTE MG               28217

-------
                                List  of All Registrants  Sent This  Data Call-in Notice^
Ca» t and Kama
0632   Barium  metaborate
Chamiaal f and Nana
011104   Sodium  metaborate
                         (NaB02)
Company Number  Company Home
                                                Additional NB
                                                                                 Addcaaa
                                                                                                                 City & State
                                                                                                                                              Zip
000100
000690
O00802
001769
002869
004236
005905
007001
007413
009754
010827
011440
019713
033S60
048211
CIBA-GEIGY CORP.
PERK PRODUCTS MID CHEMICAL CO., IN
CHAS H. LILLY CO.
NCH CORF
CRYSTAL CHEM CORP
BANDWAGON  HFC IMC
HELENA CHEMICAL CO
J.R. SIMPIOT CO.
PENHIHCTON EtWBRPRXSBS,  IHC.
GRO-LTFE
CHEMICAL SPECIALTIES IHC.
LANE LAB .  IHC.
DREXEL CHEMICAL CO
PRO SERVE  INC
INTERCOM CHEMICAL
P.O. BOX 18300
BOX 1005B5
7737 H.B.
2727 CHEMSEARCtf BLVD.
101-02 373H AVEITOE
54 IHDUSTPJAL HA7
6075 POPLAR KVE SUI3E 500
BOX 193
BOX 290
810 E. 1STH STREET
P. O. BOX 312
BOX 24632
BOX 9306
400 EAST BROOKS RD BOX 161059
1100 CEOTRM, INDUSTRIAL DR
GREENSBORO NC
NASHVILLE, TM
PORTLAND OR
IRVING TX
COROHA HY
WILMINGTON MA
MEMPHIS TN
LRTHROEE CA
MADISON GA
LOS AMGEISS CA
SMI MARCOS IX
LOS AHCE1ES CA
ME1PBIS TN
MEMPHIS TH
31. LOUIS MO
27419
37210
97216
75062
11368
01887
38119
95330
30650
90021
7B666
90024
36109
38186
63110

-------

-------
                      Attachment 7



         Cost Share and Data Compensation Forms



                          and



Confidential Statement of" Formula Form with. Instructions

-------

-------
    SEPA
                        United States Environmental Protection  Agency
                                    Washington, DC 20480
                           CERTIFICATION OF OFFER TO  COST
                        SHARE IN THE  DEVELOPMENT OF  DATA
Font Approved

OUB llo. 3070410*
        20-MWXK7
Approval Expire*  3-31-M
 PubDc reporting burden for this colectlon of information Is estimated to average 15 minutes per response, Including
 time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and
 completing and reviewing the collection of Information. Send comments regarding the buiden estimate or any other
 aspect of this collection of Information, Including suggestions for reducing this burden, to Chief, information Poficy
 Branch, PM-223, US, Environmental Protection Agency, 401 M St., S.W.. Washington. DC 20460; and to the Office
 ot Management and Budget, Paperwork Reduction Project (2070-0106). Washington. DC £0503.

 Pleas* fill  in blanks below.
                                                                        Company Nmihr
                                                                       KPA
 ! Certify that:

 My company is willing to develop and submit the data required by EPA under the authority of the Federal
 Insecticide, Fungicide and RodenUdde Act (FIFRA), if necessary.  However, my company would prefer to
 enter into an agreement with one or more registrants to develop jointly or share In the cost of developing
 data,

 My firm has offered in writing to enter into such an agreement That offer was Irrevocable and included an
 offer to be bound by arbitration decision under section 3(c}(2}(B)(S} of FiFRA if final agreement on all
 terms could not be reached otherwise.  This offer was made to the following firmfs) on the following
 dat«(s):
  NMW of
                                                                        DSM of Offer
I «r% trial I am o\ilyautriorfead» represent me corpany named abo                           have made on
this Ibnn art aB attachments therein are                        ladtnowledgetrifflanylawwingJyfalseof
misleading statement may be punishable by fine or imprisonment or both under applicable taw.
Signature •! C«mp»y'» Authority fUpWM«i*i|v»
HWM M4 Till* (Pteu* Typ* «r
D»i*
Print)
EPA lorn BS7O-32 (»J)
                             Fo»it5W,wUcHi

-------

-------
    &EPA
                         Untted States  Environmental  Prottctlon Agancy
                                    Washington,  DC  204M
                            CERTIFICATION  WITH  RESPECT TO
                         DATA  COMPENSATION  REQUIREMENTS
30-ro-ai.ai
      ii
      JJ1-M
                                                                                 . tackling
  Pubfie reporting burten for this cofttctlon of Womwiten if estimated to *v«r»Q* 1» mlrwe* ptf
  tun* tor reviewing tnstiuetions, Matching existing dau sources, gathering and fflairtainine thTdS
  completing irrfwitwiflgt^oo^aJWioJWormiiion. Send comrmnurtparaing tht burton id malt or ^yotr»f
  aspect of IMS collection ol infonnation. indbding suggestions tor reducing vat burden. to Cnitl. informBtion PoBw
  Braneft. PM-223. U.S. ErwironiMntai Prot«Jcn Agency, 401 M StH S.WH Wafrtngon, DC 20460: and to the Office
  of Managamani and Budgtt, Paptrwoffc RtducDon Piojact (2070-0106), Washirvton.  DC 20503.
  PIMM fifl In Blanks telow.


CMBpwny MumWr
B»A ftag. Ho*
i.
    For each stixiy cttfo* In support of rtgistration or irtgisiratimimdtrth«Fao^rallr»acttoie>,^ingiddtand
    RcdenSctit As (FIFBA) mat H an txekttivt use study, I am tha original data BubfrMv. or ihavtobtakitd the
    written permission of tht original data submaurio eft* thai study.

    That tor taeh study efttd in support of ngistrstion or ntftgistratbnuriternFfUlhatitNOTantwlusivtuse
    study, 1 am the original data submmtf. or I have obtained tr» wrtnen ptRnissionolirtaoriginatdaiasut)n«ttr,orl
    havanotJtitdkiwrting tha oornpanyOas) ihat submited data I have dud and haveofftredio: (a) Pay
    OBnp«rttationtortf«sadatainaeeordancaw8hstctioris3(c)(t)(0} and3{e){2}(D)e( FJFRA;and (b> Commene*
    negotiation to dftermlnt wMefi data aft subfect to iht mmpensjtioflrtquirtmeni of nFRA and th* amount e<
    compensation due, « any. lha compinws I tiava notified ant:  (ehaekona)
   (I  tht corrpani«wnohavesubm««!hettucBt$ fisted on tha backofthiifonnoraltaehad
       sh*«s. or inolcaitd on tha aBacnad •flsouirtmenti Status and Rtgistnms* Response Fotm,-
      — ~™i — -••••MU»•• »• •••xii»M rmjuHwiivML* <*iBun «i*j nw^i»u*ia» rmponsv p^im,

I. 7haiihaviprtviousJyramplao*Mihsta]m^
  reffstntttenof laieyliiiaiion under FiFBA.

sifi«in                                                  ^^"""^^^"TDStT™^1™1^
     M* TU» (PIMM Tt>* tf MM}
OEr^RAL OFFER TO PAY: I heteby offer a^agrw to pay compenigtiontp other pen)ons,^n regard to uw
ngitintion or ren>gi$tnti&n of my produeu,»tht extent required by FIFRA sadiens 3(cKi)(0) and 3(e}(2)[0}.
NWM mi TUto (PtecM Tys* tf
        a*n-n

-------

-------
g
O

H
5
ce

1
1
^
  •8


  c

 ii
DD
t^
||


 111
  UJ

          r

           i.





           I
              N
              H
               HW





               II-
               I
               !
              !||
               5

               0
                                            1
                                              £

                                             I
                                              i
                                              i
                                              r
                                             ^
                                             8

-------
Instructions for Completing the Confidential Statement of Formula

     The Confidential Statement of Formula (CSF)  Form 8570-4 must
be used.  Two legible, signed copies of the form are required.
The following list provides some basic instructions:

a.   All the blocks on the form must be filled in and answered
     completely.

b.   If any block is not applicable, mark it N/A.

c.   The CSF must be signed, dated and the telephone number of
     the responsible party must be provided.

d.   All applicable information which is on the product specific
     data submission must also be reported on the CSF.

e.   All weights reported under item 7 must be in pounds per
     gallon for liquids and pounds per cubic feet for solids.

f.   Flashpoint must be in degrees Fahrenheit and flame extension
     in inches.

g.   For all active ingredients, the EPA Registration Numbers for
     the currently registered source products must be reported
     under column 12.

h.   The Chemical Abstracts Service  (CAS) Numbers for all actives
     and inerta and all common names for the trade names must be
     reported.

i.   For the active ingredients, the percent purity of the  source
     products must be reported under column 10 and must be
     exactly the same as on the source product's label.

j.   All the weights  in columns 13.a. and 13.b. must be in
     pounds, kilograms, or grams. In no case will volumes be
     accepted. Do not mix English and metric system units  (i.e.,
     pounds and kilograms).

k.   All the items under column 13.b. must  total 100 percent.

1.   All items under  columns 14.a.  and 14.b. for the active
     ingredients must represent pure active form.

m.   The upper and lower certified  limits for ail active and
     inert  ingredients must follow  the 40 CFR 158.175
     instructions. An explanation must be provided  if  the
     proposed limits  are different  than  standard certified
     limits.

n.   When new CSFs are  submitted and approved, all  previously
     submitted  CSFs  become  obsolete for  that specific
     formulation.

-------