United States
Environmental Protection
Agency
Prevention, Pesticides
And Toxic Substances
(7508W)
EPA-738-F-97-013
September 1997
R.E.D. FACTS
Thiobencarb
Pesticide
Reregistration
Use Profile
Regulatory
History
All pesticides sold or distributed in the United States must be
registered by EPA, based on scientific studies showing that they can be
used without posing unreasonable risks to people or the environment.
Because of advances in scientific knowledge, the law requires that
pesticides which were first registered before November 1, 1984, be
reregistered to ensure that they meet today's more stringent standards.
In evaluating pesticides for reregistration, EPA obtains and reviews a
complete set of studies from pesticide producers, describing the human
health and environmental effects of each pesticide. To implement
provisions of the Food Quality Protection Act of 1996, EPA considers the
special sensitivity of infants and children to pesticides, as well as aggregate
exposure of the public to pesticide residues from all sources, and the
cumulative effects of pesticides and other compounds with common
mechanisms of toxicity. The Agency develops any mitigation measures or
regulatory controls needed to effectively reduce each pesticide's risks. EPA
then reregisters pesticides that meet the safety standard of the FQPA and
can be used without posing unreasonable risks to human health or the
environment.
When a pesticide is eligible for reregistration, EPA explains the basis
for its decision in a Reregistration Eligibility Decision (RED) document.
This fact sheet summarizes the information in the RED document for
reregistration case 2665, Thiobencarb.
Thiobencarb is a systemic, pre-emergence herbicide that acts by
inhibiting shoots of emerging seedlings. It is used to control grasses, sedge
and broadleaf weeds in food crops such as rice (represents 95% of use),
lettuce, celery, and endive. Formulations include a liquid and a granular.
Thiobencarb may be applied using ground spray equipment or by aircraft.
Thiobencarb was first registered for use on rice in 1982. In 1991,
thiobencarb was issued regional tolerances for use on celery, endives, and
lettuce in the State of Florida.
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Currently, there are five products containing thiobencarb registered
under Section 3 of the Federal Insecticide, Fungicide, and Rodenticide Act.
They consist of one technical (manufacturing use) product containing
97.4% active ingredient, two emulsifiable concentrate end-use products
each containing 84.0% active ingredient, and two granular end-use products
each containing 10.0% active ingredient.
Human Health
Assessment
Toxicity
In studies using laboratory animals, thiobencarb generally has been
shown to be of low acute toxicity. It is slightly toxic by the oral and dermal
route and has been placed in category III for these effects. It is practically
non-toxic by the inhalation route and for eye irritation, and has been placed
in Toxicity Category IV (the lowest of four categories) for these effects.
Thiobencarb also tested negative for mutagenicity.
Dietary Exposure
People may be exposed to residues of thiobencarb through the diet.
Tolerances have been established for celery, lettuce, endive (escarole), rice
(grain and straw), and for animal commodities including milk and eggs, and
the fat, meat, and meat by-products of cattle, hogs, poultry, sheep, goats
and horses (please see 40 CFR 180.401(a) and (b)). EPA has reassessed the
thiobencarb tolerances and found that they are acceptable.
Occupational and Residential Exposure
Exposure to homeowners is not expected since there are no residential
uses. Based on current use patterns, handlers (mixers, loaders, and
applicators) may be exposed to thiobencarb during and after normal
agricultural use.
The risks calculated from intermediate-term exposures to thiobencarb
indicate that risks from exposures to granular formulations (loading and
applying) are lower than those from exposures to the liquid formulation/
spray applications. For the granular formulations, the MOEs exceed 100
for all scenarios (except loading to support aerial application) with the
addition of personal protective equipment. For many of the liquid
formulation/spray application scenarios, the MOEs do not reach 100, even
with engineering controls.
Granular Formulations: The Agency believes the risks resulting from
intermediate-term exposures to the granular formulation are overestimated
due to the use of a 60.2 percent dermal absorption value for the granular
scenarios. In general, dermal absorption of granular formulations has been
found to be significantly lower than for liquid formulations. Therefore, the
Agency has determined that risks to handlers of granular formulations will
be adequately mitigated with the addition of personal protective equipment.
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Liquid Formulations: The Agency believes that risks resulting from
intermediate-term exposures to persons handling liquid formulations are
overestimated due to limitations with the hazard identification and the dose-
response assessment for the intermediate-term endpoint, particularly in light
of the absence of serious effects to these target organs in either the
subchronic neurotoxicity or rat chronic feeding study, which suggest the
lack of a deleterious response to thiobencarb by the kidney and/or liver. The
Agency believes that risks to handlers using liquid formulations will be
adequately mitigated with the used of engineering controls and personal
protective equipment.
Human Risk Assessment
Thiobencarb generally is of low acute toxicity, and has been classified
in Group D (not classifiable as to human carcinogenicity). Food crop uses
are registered including rice, lettuce, endive and escarole. However,
dietary exposure to thiobencarb residues in foods is extremely low, as is the
cancer risk posed to the general population.
Of greater concern is the risk posed to thiobencarb handlers,
particularly mixers/loaders/applicators, and field workers who come into
contact with treated crops following application of this pesticide. Exposure
and risk to workers will be mitigated by the use of PPE required by the
WPS, supplemented by engineering controls as required by this RED.
For post-application workers, since no dislodgeable foliar residue
studies or concurrent dermal samples were submitted to the EPA for
thiobencarb to measure postapplication reentry, a rough surrogate
postapplication assessment was performed as a default. Only the short-term
endpoint (25 mg/kg/day) was used for the risk assessment, since EPA does
not anticipate that intermediate-term exposures (i.e., 7 days or more of
exposure) are likely to occur for post-application workers for these crops in
early-stage development. EPA assumed in the surrogate assessment that
dermal absorption would be significantly lower that the 60.2 percent used in
the handler assessment, since dermal exposure would be to dry residues.
The surrogate postapplication risk assessment indicated that at all
application rates (i.e., 4-8 pounds active ingredient per acre), risks would be
acceptable to post-application workers entering treated areas to perform
tasks such as scouting, thinning, or hoeing, provided entry is postponed for
24 hours following application.
FQPA Considerations
The FQPA of 1996 amended the FFDCA by setting a new safety
standard for the establishment of tolerances and directs the EPA to consider
available information concerning the susceptibility of infants and children
to pesticide residues in food. Based on the review of available data and the
absence of incident or epidemiological data for thiobencarb, an additional
safety factor for the protection of children is not necessary. The FQPA also
requires EPA to consider aggregate exposure to the pesticide residue,
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including all anticipated dietary exposure and other exposures for which
there is reliable information, as well as cumulative effects from the
pesticide and other substances that have a common mechanism of toxicity.
EPA has assessed the dietary risk posed by thiobencarb. In assessing
chronic dietary risk , EPA estimates that thiobencarb residues in food
sources account for < 42.9% of the RfD, and include the highest-at-risk
subgroup, non-nursing infants. In drinking water thiobencarb residues
account for 0.29% of the RfD. Thus, the aggregate exposures from all
sources of thiobencarb (in this case, only dietary and drinking water
exposures are relevant) account for 43.2% of the RfD. Therefore, the
Agency concludes that aggregate risks for the general population resulting
from thiobencarb uses are not of concern.
EPA estimates that thiobencarb residues in the diet of infants and
children account for 42.9% of the RfD (29.5 for children 1-5) and residues
in drinking water account for 0.29% of the RfD. Thus the aggregate
exposure from all sources of thiobencarb account for 43.2% of the RfD for
infants and children. Therefore, the Agency concludes that aggregate risks
for infants and children resulting from uses of thiobencarb are not of
concern.
Environmental Environmental Fate
AsSGSSITIGnt Thiobencarb is slightly persistent in water, generally not very mobile,
tends to bind to soil organic matter, and doesn't desorb. Generally,
thiobencarb is stable to degradation by hydrolysis and is stable under
anaerobic aquatic conditions. Thiobencarb meets the persistence and
mobility triggers for classification as a restricted-use chemical for ground-
water concerns, but not the detections triggers. The Agency believes that
ground water concerns do not warrant use restrictions. Furthermore, due to
the binding nature of the active ingredient, any thiobencarb that may reach
surface water will be predominantly bound with suspended solids and
sediments. Standard coagulation and flocculation processes used in plants
are expected to remove most of the suspended solids and sediments from
the water, thereby removing most of the potential risk of thiobencarb in
drinking water.
Ecological Effects
Use of liquid formulations of thiobencarb pose some acute risk to
mammals. The acute risk to birds is minimal. Use of liquid formulations
pose a high chronic risk to birds and mammals.
Use of thiobencarb on rice in the southeast US poses a high risk of
chronic effects to freshwater and estuarine aquatic invertebrates, including
shrimp and mollusks. There is also likely a high risk of chronic effects to
fish, but additional data are needed to confirm this. This use of thiobencarb
also poses a high risk of acute effects to fish and aquatic invertebrates in
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certain high-exposure situations. Additionally, use of thiobencarb on rice in
California poses a risk of causing chronic effects to aquatic organisms in
the smaller drains and waterways, but not in the larger rivers. Thiobencarb
use poses minimal risk of acute effects to fish and aquatic invertebrates.
Minimal risk of both acute and chronic effects is expected for all estuarine
organisms in California. Spray drift from aerial application of liquid
thiobencarb on rice poses a high risk to nontarget terrestrial and semiaquatic
plants. Drift of granular thiobencarb and spraying of liquid thiobencarb
applied with ground equipment pose minimal risk to these plants. All uses
of thiobencarb on rice may pose a risk of killing emerging seedlings of
aquatic plants, especially aquatic grasses. Use of thiobencarb on rice may
pose a risk to aquatic algae in the southeast US and in smaller drains and
waterways in California.
Use of thiobencarb on celery, lettuce, and endive in Florida poses a
high risk of causing chronic effects to fish, freshwater invertebrates, and
estuarine invertebrates, including shrimp. Additionally, this use poses a
high risk of causing acute effects to freshwater and estuarine invertebrates,
including oysters and shrimp. Use of thiobencarb on celery, lettuce, and
endive in Florida poses a high risk to terrestrial plants, semiaquatic plants,
and algae. It may also pose a risk to emerging seedlings of vascular aquatic
plants.
Environmental Risk Characterization
Of particular concern to the Agency is the high risk of chronic effects
to fish and freshwater invertebrates, including shrimp and mollusks, and the
high risk of causing acute effects to freshwater and invertebrates, and the
water quality risks posed by the chemical.
Risk Mitigation To lessen worker risk, and ecological and water quality risks posed by
thiobencarb, EPA is requiring the following mitigation measures from
registrants of thiobencarb-containing products.
To protect handlers:
• For liquid formulations: mixers and loaders must used closed systems
in addition to wearing a chemical-resistant apron, chemical-resistant
gloves, long-sleeve shirt, long pants, shoes, and socks. Applicators
and flaggers must use enclosed cabs or cockpits and wear long-sleeve
shirt, long pants, shoes, and socks.
For granular formulations: loaders must wear a chemical-resistant
apron, chemical-resistant gloves, long-sleeve shirt, long pants, shoes,
and socks. Applicators and flaggers must wear chemical-resistant
gloves, long-sleeve shirt, long pants, shoes, and socks.
To protect workers:
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A restricted-entry interval of 24 hours is being imposed. Early entry
workers must wear coveralls, chemical-resistant gloves, shoes, and
socks.
To protect non-target organisms:
• Application restrictions are being mandated in the states of
Louisiana and Texas. In Louisiana, thiobencarb application will not
be allowed south of the Intracoastal Waterway. In Texas,
thiobencarb application will not be allowed within two miles inland
from the shorelines of Galveston Bay, and not within two miles of
Matagorda Bay.
• Include label warnings preventing application to rice fields with
catfish/crayfish farming, and preventing application to rice fields
adjacent to catfish or crayfish ponds.
Where weather conditions permit, it is required that flood waters not
be released within 14 days.
Require that thiobencarb not be applied within 24 hours of rainfall,
or when heavy rain is expected to occur within 24 hours.
• Require that thiobencarb not be mixed/loaded or otherwise handled
within 100 feet of aquatic habitat.
• Continue existing label warnings addressing environmental hazards,
such as restricting application aerially within one mile of the St.
Francis Floodway where the Fat Pocketbook Pearly Mussel is
known to occur. Comparable warnings would be appropriate where
use on rice can expose other threatened and endangered mussels.
• Work with the EPA to reassess in the Fall of 1998 thiobencarb use
on leafy vegetables in Florida based on the results of the currently
ongoing environmental monitoring study for muck soils in Florida
from the U.S. Geological Survey's National Water Quality
Assessment Program (NAWQA).
Additional Data EPA is requiring the following additional generic studies for
Required thiobencarb to confirm its regulatory assessments and conclusions:
• Dermal Penetration Study [GLN 85-2];
• Life-Cycle Freshwater Fish Study [GLN 72-5];
• Avian Subacute Toxicity Study [GLN 71-2(b)];
• Avian Reproduction Study [GLN 71-4(b)];
• Seedling Emergence Testing Study [GLN 123-1 (a)];
The Agency also is requiring product-specific data including product
chemistry and acute toxicity studies, revised Confidential Statements of
Formula (CSFs), and revised labeling for reregi strati on.
Product Labeling All thiobencarb end-use products must comply with EPA's current
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Changes
Required
pesticide product labeling requirements and with the following
requirements:
Labeling Requirements for Manufacturing-Use Products
To remain in compliance with FIFRA, manufacturing use product
(MP) labeling must be revised to comply with all current EPA regulations,
PR Notices and applicable policies. The MP labeling must bear the
following statement under Directions for Use:
"Only for formulation into an Herbicide for the following use(s):rice
weed control in California, Louisiana, Texas, Mississippi, Missouri
and Arkansas, and lettuce, endive and celery weed control in
Florida."
An MP registrant may, at his/her discretion, add one of the following
statements to an MP label under "Directions for Use" to permit the
reformulation of the product for a specific use or all additional uses
supported by a formulator or user group:
(a) "This product may be used to formulate products for
specific use(s) not listed on the MP label if the
formulator, user group, or grower has complied with
U.S. EPA submission requirements regarding
support of such use(s)."
(b) "This product may be used to formulate products for
any additional use(s) not listed on the MP label if the
formulator, user group, or grower has complied with
U.S. EPA submission requirements regarding
support of such use(s)."
Labeling Requirements for End-Use Products
The labels and labeling of all products must comply with
EPA's current regulations and requirements as specified in 40 CFR
§156.10 and other applicable notices.
PPE and Engineering Control Requirements for Pesticide Handlers
For sole-active-ingredient end-use products that contain
thiobencarb:
• Revise the product labeling to adopt the handler personal
protective equipment/engineering control requirements set
forth in this section.
• Remove any conflicting PPE requirements on the current
labeling.
For multiple-active-ingredient end-use products that contain
thiobencarb:
• Compare the handler personal protective
equipment/engineering control requirements set forth in this
section to the requirements on the current labeling.
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• Retain the more protective requirements. (For guidance on
which requirements are considered more protective, see PR
Notice 93-7.)
Active-Ingredient Specific Engineering Control Requirements
EPA is establishing active-ingredient specific engineering controls for
some occupational uses of thiobencarb end-use products.
For liquid formulations:
"Mixers and loaders are required to use closed
systems. The closed system must be used in a
manner that meets the requirements listed in the
Worker Protection Standard (WPS) for agricultural
pesticides (40 CFR 170.240(d)(4)."
"Applicators and flaggers are required to use enclosed cabs
or enclosed cockpits. The closed system must be used in a
manner that meets the requirements listed in the Worker
Protection Standard (WPS) for agricultural pesticides (40
CFR 170.240(d)(5-6)."
Active-Ingredient Specific Personal Protective Equipment Requirements
EPA is establishing active-ingredient specific personal
protective equipment requirements for all occupational uses of
thiobencarb end-use products.
For liquid formulations:
"In addition to using closed systems, mixers and loaders
must wear:
— long-sleeved shirt and long pants,
—chemical-resistant gloves*,
—socks plus shoes, and
—chemical-resistant apron."
"Applicators and flaggers using enclosed cabs or cockpits
must wear:
— long-sleeved shirt and long pants, and
—socks plus shoes."
"For other handling activities and in case of a spill or other
emergency exposure, handlers must wear:
—coveralls over long-sleeved shirt and long pants,
—chemical-resistant gloves*,
—chemical-resistant footwear, and
—chemical-resistant apron when cleaning equipment."
*For the glove statement, use the statement established for
thiobencarb through the instructions in Supplement Three of
PR Notice 93-7.
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For granular formulations:
"Applicators and other handlers must wear:
— long-sleeved shirt and long pants,
—chemical-resistant gloves*,
— shoes plus socks
—chemical-resistant apron when loading formulation into
equipment or cleaning equipment."
*For the glove statement, use the statement established for
thiobencarb through the instructions in Supplement Three of
PR Notice 93-7.
a. Entry Restrictions
For sole-active-ingredient end-use products that contain
thiobencarb:
• Revise the product labeling to adopt the entry restrictions set
forth in this section.
• Remove any conflicting entry restrictions on the current
labeling.
For multiple-active-ingredient end-use products that contain
thiobencarb:
• Compare the entry restrictions set forth in this section to the
entry restrictions on the current labeling.
• Retain the more protective restrictions. (A specific time
period in hours or days is considered more protective than
"sprays have dried" or "dusts have settled.")
Restricted-entry interval: A 24-hour restricted-entry interval (REI) is
required for uses within the scope of the WPS on all thiobencarb end-use
products.
Early-Entry Personal Protective Equipment (PPE): The PPE required for
early entry is:
- coveralls,
- chemical-resistant gloves, and
- shoes plus socks.
Other Labeling Requirements
The Agency is requiring the following labeling statements to be
located on all end-use products containing thiobencarb:
Application Restrictions
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"Do not apply this product in a way that will contact workers or other
persons, either directly or indirectly or through drift. Only protected
handlers may be in the area during application."
"Do not apply this product south of the Intracoastal Waterway in
Louisiana."
"Do not apply this product within two (2) miles from the shorelines
of Matagorda Bay in Texas."
"Do not apply this product within two (2) miles from the shorelines
of Galveston Bay in Texas."
"Do not apply this product to rice fields with catfish/crayfish
farming."
"Do not apply this product on rice fields adjacent to catfish or
crayfish ponds."
"When applying to rice fields, do not release permanent flood water
within 14-days of application of this product (where weather
permits)."
"Avoid application of this product within 24 hours of rainfall, or
when heavy rain is expected to occur within 24 hours."
"Do not mix/load or otherwise handle this product within 100 feet of
aquatic habitat."
ii. User Safety Requirements
"Discard clothing or other absorbent materials that have been
drenched or heavily contaminated with this product's concentrate.
Do not reuse them."
"Follow manufacturer's instructions for cleaning/maintaining PPE. If
there are not such instructions for washables, use detergent and hot
water. Keep and wash PPE separately from other laundry."
iii. User Safety Recommendations
"Users should wash hands before eating, drinking, chewing gum,
using tobacco, or using the toilet."
"Users should remove clothing immediately if pesticide gets inside.
Then wash thoroughly and put on clean clothing."
"Users should remove PPE immediately after handling this product.
Wash the outside of gloves before removing. As soon as possible,
wash thoroughly and change into clean clothing."
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iv. Spray Drift Labeling
The following language must be placed on each product label that
can be applied aerially:
Avoiding spray drift at the application site is the responsibility of the
applicator. The interaction of many equipment-and-weather-related
factors determine the potential for spray drift. The applicator and the
grower are responsible for considering all these factors when making
decisions.
The following Aerial Drift Reduction Advisory Information must be
followed to avoid off-target drift movement from aerial applications
to agricultural field crops. These requirements do not apply to
forestry applications, public health uses or to applications using dry
formulations.
1. The distance of the outer most nozzles on the boom must not
exceed 3/4 the length of the wingspan or rotor.
2. Nozzles must always point backward parallel with the air
stream and never be pointed downwards more than 45
degrees.
Where states have more stringent regulations, they should be
observed.
It is recommended that the applicator should be familiar with and
take into account the information covered in the Aerial Drift
Reduction Advisory Information.
The following aerial drift reduction advisory information must be
contained in the product labeling:
[This section is advisory in nature and does not supersede the
mandatory label requirements.]
INFORMATION ON DROPLET SIZE: The most effective way to
reduce drift potential is to apply large droplets. The best drift
management strategy is to apply the largest droplets that provide
sufficient coverage and control. Applying larger droplets reduces
drift potential, but will not prevent drift if applications are made
improperly, or under unfavorable environmental conditions (see
Wind, Temperature and Humidity, and Temperature Inversions).
CONTROLLING DROPLET SIZE
• Volume - Use high flow rate nozzles to apply the highest
practical spray volume. Nozzles with higher rated flows produce
larger droplets.
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• Pressure - Do not exceed the nozzle manufacturer's
recommended pressures. For many nozzle types lower pressure
produces larger droplets. When higher flow rates are needed, use
higher flow rate nozzles instead of increasing pressure.
• Number of nozzles - Use the minimum number of nozzles
that provide uniform coverage.
• Nozzle Orientation - Orienting nozzles so that the spray is
released parallel to the airstream produces larger droplets than other
orientations and is the recommended practice. Significant deflection
from horizontal will reduce droplet size and increase drift potential.
• Nozzle Type - Use a nozzle type that is designed for the
intended application. With most nozzle types, narrower spray angles
produce larger droplets. Consider using low-drift nozzles. Solid
stream nozzles oriented straight back produce the largest droplets and
the lowest drift.
• Maintenance of Nozzles - periodic inspection and subsequent
replacement of nozzles to ensure proper chemical application is
recommended.
BOOM LENGTH: For some use patterns, reducing the effective
boom length to less than 3/4 of the wingspan or rotor length may
further reduce drift without reducing swath width.
APPLICATION HEIGHT: Applications should not be made at a
height greater than 10 feet above the top of the largest plants unless a
greater height is required for aircraft safety. Making applications at
the lowest height that is safe reduces exposure of droplets to
evaporation and wind.
SWATH ADJUSTMENT: When applications are made with a
crosswind, the swath will be displaced downward. Therefore, on the
up and downwind edges of the field, the applicator must compensate
for this displacement by adjusting the path of the aircraft upwind.
Swath adjustment distance should increase, with increasing drift
potential (higher wind, smaller drops, etc.)
WIND: Drift potential is lowest between wind speeds of 2-10 mph.
However, many factors, including droplet size and equipment type
determine drift potential at any given speed. Application should be
avoided below 2 mph due to variable wind direction and high
inversion potential. NOTE: Local terrain can influence wind
patterns. Every applicator should be familiar with local wind patterns
and how they affect spray drift.
TEMPERATURE AND HUMIDITY: When making applications
in low relative humidity, set up equipment to produce larger droplets
to compensate for evaporation. Droplet evaporation is most severe
when conditions are both hot and dry.
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Regulatory
Conclusion
For More
Information
TEMPERATURE INVERSIONS: Applications should not occur
during a temperature inversion because drift potential is high.
Temperature inversions restrict vertical air mixing, which causes
small suspended droplets to remain in a concentrated cloud. This
cloud can move in unpredictable directions due to the light variable
winds common during inversions. Temperature inversions are
characterized by increasing temperatures with altitude and are
common on nights with limited cloud cover and light to no wind.
They begin to form as the sun sets and often continue into the
morning. Their presence can be indicated by ground fog; however, if
fog is not present, inversions can also be identified by the movement
of smoke from a ground source or an aircraft smoke generator.
Smoke that layers and moves laterally in a concentrated cloud (under
low wind conditions) indicates an inversion, while smoke that moves
upward and rapidly dissipates indicates good vertical air mixing.
SENSITIVE AREAS: The pesticide should only be applied when
the potential for drift to adjacent sensitive areas (e.g. residential areas,
bodies of water, known habitat for threatened or endangered species,
non-target crops) is minimal (e.g. when wind is blowing away from
the sensitive areas).
The use of currently registered products containing thiobencarb in
accordance with approved labeling will not pose unreasonable risks or
adverse effects to humans or the environment. Therefore, all uses of these
products are eligible for reregi strati on.
Thiobencarb products will be reregistered once the required product-
specific data, revised Confidential Statements of Formula, and revised
labeling are received and accepted by EPA.
EPA is requesting public comments on the Reregi strati on Eligibility
Decision (RED) document for thiobencarb during a 60-day time period, as
announced in a Notice of Availability published in the Federal Register. To
obtain a copy of the RED document or to submit written comments, please
contact the Pesticide Docket, Public Information and Records Integrity
Branch, Information Resources and Services Division (7502C), Office of
Pesticide Programs (OPP), US EPA, Washington, DC 20460, telephone
703-305-5805.
Electronic copies of the RED and this fact sheet are available on the
Internet. See http://www.epa.gov/REDs.
Printed copies of the RED and fact sheet can be obtained from EPA's
National Center for Environmental Publications and Information
(EPA/NCEPI), PO Box 42419, Cincinnati, OH 45242-2419, telephone 1-
800-490-9198; fax 513-489-8695.
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Following the comment period, the thiobencarb RED document also
will be available from the National Technical Information Service (NTIS),
5285 Port Royal Road, Springfield, VA 22161, telephone 703-487-4650.
For more information about EPA's pesticide reregi strati on program,
thethiobencarb RED, or reregi strati on of individual products containing
thiobencarb], please contact the Special Review and Reregi strati on Division
(7508W), OPP, US EPA, Washington, DC 20460, telephone 703-308-8000.
For information about the health effects of pesticides, or for
assistance in recognizing and managing pesticide poisoning symptoms,
please contact the National Pesticides Telecommunications Network
(NPTN). Call toll-free 1-800-858-7378, from 6:30 am to 4:30 pm Pacific
Time, or 9:30 am to 7:30 pm Eastern Standard Time, seven days a week.
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