United States
                 Environmental Protection
                      Prevention, Pesticides
                      And Toxic Substances
December 1998
                 R.E.D.   FACTS
     All pesticides sold or distributed in the United States must be registered
by EPA, based on scientific studies showing that they can be used without
posing unreasonable risks to people or the environment. Because of advances
in scientific knowledge, the law requires that pesticides which were first
registered before November 1, 1984, be reregistered to ensure that they meet
today's more stringent standards.
                      In evaluating pesticides for reregistration, EPA obtains and reviews a
                 complete set of studies from pesticide producers, describing the human health
                 and environmental effects of each pesticide. To implement provisions of the
                 Food Quality Protection Act (FQPA) of 1996, EPA considers the special
                 sensitivity of infants and children to pesticides, as well as aggregate exposure
                 of the public to pesticide residues from all sources, and the cumulative effects
                 of pesticides and other compounds with common mechanisms of toxicity.  The
                 Agency develops any mitigation measures or regulatory controls needed to
                 effectively reduce each pesticide's risks. EPA then reregisters pesticides that
                 meet the safety standard of the FQPA and can be used without posing
                 unreasonable risks to human health or the environment.

                      When a pesticide is eligible for reregistration, EPA explains the basis for
                 its decision in a Reregistration Eligibility Decision (RED) document.  This fact
                 sheet summarizes the information in the RED document for reregistration case
                 2585, hydramethylnon.
   Use Profile
     Hydramethylnon is an insecticide used to control ants, cockroaches,
crickets, and termites.  There are 28 end use product formulations that are
either granular baits or ready-to-use gelatin. The use on rangelands or pastures
primarily for Imported Fire ant control, is considered to be a food use and
established tolerances are cited in 40 CFR Section 180.395. Hydramethylnon
completely metabolizes within the body of foraging ruminants so there is an
exemption from the requirement of a tolerance for meat, milk, and meat
     Hydramethylnon was first registered as a pesticide in the U.S. in 1980.

 Human Health
As part of the reregi strati on process the Agency issued Data Call-Ins (DCI) for
data needed to support the continued registration of hydramethylnon products.
These DCIs required environmental fate, ecological effects, and toxicological
data. In addition, data to support the agricultural and residential grass use
were requested.

     In studies using laboratory animals, hydramethylnon generally has been
shown to be of low acute toxicity.  It has been placed in Toxicity Category III
for effects via the oral route of exposure and eye irritation, and Toxicity
Category IV for the dermal and inhalation routes.  The Cancer Peer Review
Committee  determined that hydramethylnon should be classified as a Group C
carcinogen, a possible human carcinogen, based upon statistically significant
lung adenomas and carcinomas.
Dietary Exposure
     People are not likely to be exposed to residues of hydramethylnon either
through their diet or drinking water.  There are tolerances for grass  orage and
hay by grazing and foraging cattle but there are no food or feed residues and
groundwater contamination from hydramethylnon is unlikely.
Occupational Exposure
     Workers are most likely to be exposed to hydramethylnon by application
of the ready-to-use gelatins to kitchen counter tops but these exposures are
minimal.  EPA is generally not concerned with occupational risk if MOEs
(margins of exposures) are greater than 100.
Other Considerations
     Because hydramethylnon is considered a food use the specific
determinations outlined in FQPA were taken into consideration. Contact by
infants or children with the ready-to-use gelatin product from food preparaton
counter top is unlikely and exposure from drinking water is not expected.
     The Agency has not made a determination whether hydramethylnon and
any other pesticide have a common mechanism of toxicity that would require a
cumulative  risk assessment. For the purposes of this RED, EPA has
considered only the risks from hydramethylnon.  If required,  cumulative risks
will be assessed when methodologies for determining common mechanism of
toxicity and for performing cumulative risk assessments are finalized.
Environmental   Environmental Fate
   Assessment        For the currently registered uses of hydramethylnon, the Agency
                     typically requires an abbreviated set of environmental fate data on hydrolysis,
                     metabolism, and mobility.
                          Based on existing data, hydramethylnon is likely to be moderately
                     persistent to persistent and relatively immobile in terrestrial environments.

                         Hydramethylnon is stable to abiotic hydrolysis and photodegradation on soil.
                         It does not exhibit fate and transport characteristics similar to chemicals that
                         are known to leach to groundwater.
                         Ecological Effects/Risk
                               Calculated acute avian risks do not exceed the Level of Concern (LOG).
                         The Agency concludes that the overall acute impact on freshwater and
                         terrestrial non-target organisms from the use of hydramethylnon for insect
                         control will be minimal.  The Agency is requiring an avian reproduction study
                         for confirmatory purposes.

    Risk Mitigation        The Agency is requiring the use of water resistant gloves and a 12 hour
                         re-entry interval.  The  Agency is also establishing the minimum Worker
                         Protection Standard (WPS) Personal Protective Equipment (PPE) of coveralls,
                         water-resistant gloves, shoes and socks for early re-entry.

    Additional Data        EPA is requiring product-specific data including product chemistry and
            Required  acute toxicity studies,  and revised labeling for reregistration. Some additional
                         ecological effects and  environmental fate data are being required for
                         confirmatory purposes.
  Product Labeling
Changes Required
     All hydramethylnon end-use products must comply with EPA's current
pesticide product labeling requirements and the water resistant glove
requirement, the 12 hour restricted entry interval, the early entry PPE
requirements and the user safety recommendations below. The following
labeling changes are required.
                         User Safety Recommendations
                               !    "Users should wash hands before eating, drinking, chewing gum,
                                    using tobacco, or using the toilet."
                               !    "Users should remove clothing immediately if pesticide gets inside.
                                    Then wash thoroughly and put on clean clothing."
                               !    "Users should remove protective clothing and equipment
                                    immediately after handling this product. Wash the outside of
                                    gloves before removing. Keep and wash protective clothing and
                                    equipment separately from other laundry."
         Regulatory        The use of currently registered products containing hydramethylnon in
         Conclusion   accordance with changes specified in this document will not pose unreasonable
                          risks of adverse effects to humans or the environment. Therefore, all uses of
                          these products are eligible for reregistration.

                      Hydramethylnon products will be reregistered once the required product-
                 specific data, required confirmatory generic data, product specific data,
                 confidential statements for formula, and revised labeling are received and
                 accepted by EPA.
   For More
     EPA is requesting public comments on the RED document for
hydramethylnon during a 60-day time period, as announced in a Notice of
Availability published in the Federal Register.  To obtain a copy of the RED
document or to submit written comments, please contact the Pesticide Docket,
Public Information and Records Integrity Branch, Information Resources and
Services Division (7502C), Office of Pesticide Programs (OPP), US EPA,
Washington, DC 20460, telephone (703) 305-5805.
                      Electronic copies of the RED and this fact sheet are available on the
                 Internet. See http://www.epa.gov/REDs.

                      Printed copies of the RED and Fact Sheet can be obtained from EPA's
                 National Center for Environmental Publications and Information
                 (EPA/NCEPI), P.O. Box 42419, Cincinnati, OH 45242-2419, telephone at
                 1-(800) 490-9198; fax (513) 489-8695.
                      Following the comment period, the hydramethylnon RED document also
                will be available from the National Technical Information Service (NTIS),
                5285  Port Royal Road, Springfield, Virginia 22161; telephone at (703) 605-
                6000  or 1-(800) 553-6847.
                      For more information about EPA's pesticide reregi strati on program, the
                hydramethylnon RED, or reregi strati on of individual products containing
                hydramethylnon, please contact the Special Review and Reregi strati on Division
                (7508), OPP, US EPA, Washington, DC 20460, telephone at (703) 308-8000.
                      For information about the health effects of pesticides, or for assistance in
                recognizing and managing pesticide poisoning symptoms, please contact the
                National Pesticides Telecommunications Network (NPTN). Call toll-free 1-
                (800) 858-7378, from 6:30 am to 4:30 pm Pacific Time, or 9:30 am to 7:30 pm
                Eastern Standard Time, Monday through Saturday.   Their internet address is: