United States
Environmental Protection
Agency
Prevention, Pesticides
And Toxic Substances
(7508C)
EPA-738-F-99-008
APRIL 1999
R.E.D. FACTS
Pesticide
Reregistration
*CHLOROTHALONIL*
All pesticides sold or distributed in the United States must be registered
^ EPA, based on scientific studies showing that they can be used without
posing unreasonable risks to people or the environment. Because of advances
in scientific knowledge, the law requires that pesticides which were first
registered before November 1, 1984, be reregistered to ensure that they meet
today's more stringent standards.
In evaluating pesticides for reregistration, EPA obtains and reviews 'a
complete set" of studies from pesticide producers, describing the human health -
and environmental effects of each pesticide. The Agency develops any
mitigation measures or regulatory controls needed to effectively reduce each
pesticide's risks. EPA then reregisters pesticides that can be used without
posing unreasonable risks to human health or the environment.
Use Profile
When a pesticide is eligible for reregistration, EPA explains the basis for
its decision in a Reregistration Eligibility Decision (RED) document. This fact
sheet summarizes the information in the RED document for reregistration case
0097, chlorothalonil, or 2,4,5,6-tetrachloroisophthalonitrile.
Chlorothalonil acts primarily as a fungicide and mildewicide, but also has
some activity as a bactericide, microbiocide, algaecide, insecticide, and
acaricide. It is a broad spectrum, non-systemic pesticide. Its exact mechanism
of action is not known. Chlorothalonil is registered on a wide variety of sites
including field, vegetable, and orchard crops; turf; and as a mildewicide to be
added to paint and other surface treatments. There are currently 39 tolerances
for cfflorothalonil. Application methods include hand-held duster or granule
spreader; backpack sprayer; chemigation; ultra-low, low, or high volume
ground sprayer; aircraft; air-blast; specialty air-assisted equipment; brush-on
and dip treatments; airless sprayers; and thermal fog generator. Chlorothalonil
is formulated in dust, granular (dry and water dispersible), wettable powder,
dry flowable, flowable concentrate, impregnated material, or ready-to-use
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Regulatory
History
formulations. Homeowner uses include mildewicidal additive for paint,
ornamental plants, and turf uses.
Chlorothalonil was first registered in the United States in 1966 for use on
turfgrass. GB Biosciences, Veterans Ilex, Sipcam Corporation, Thor Chemie
GMBH, and Westbridge Industries all hold registrations for manufacturing-use
product, but of these registrants, only the first two manufacture technical grade
active ingredient. A Registration Standard was issued by the Agency for
chlorothalonil in September 1984. There are 101 chlorothalonil products
registered, along with 98 Special Local Needs registrations (SLNs).
Chlorothalonil is not a restricted use pesticide.
Human Health
Assessment
Toxicity
Chlorothalonil is in acute Toxicity Category IV (the least toxic of four
• • ...,-,, - . vvi-tf
categories) for the oral route of exposure, and in Toxicity Category II for the.
inhalation route. For acute dermal effects and acute skin irritation,
chlorothalonil is in Toxicity Category IV. Chlorothalonil produces severe eye
irritation in rabbits (Toxicity Category I). The Agency has classified
chlorothalonil as a likely human carcinogen (formerly Group B2).
In determining whether to retain, reduce, or remove the lOx FQPA
safety factor for infants and children, EPA uses a weight of evidence approach
taking into account the completeness and adequacy of the toxicity data base,
the nature and severity of the effects observed in pre- and post-natal studies,
and exposure. The developmental and reproductive data for chlorothalonil
indicate that there is no evidence of an increased sensitivity to chlorothalonil
from pre- or post-natal exposures. In a rat study, the developmental LOEL
was based on resorptions and post-implantation loss. The same dose was
associated with maternal effects. No developmental toxicity was observed at
any dose level in a rabbit study, and no maternal toxicity was observed at the
highest dose tested (20 mg/kg/day). No reproductive effects were observed in
any study, and developmental effects occurred only in the presence of
significant maternal toxicity.
Based on these findings, the Agency has concluded that the ten-fold
safety factor applied according to FQPA to account for special sensitivity to
infants and children is not warranted for chlorothalonil, and should be removed.
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SDS-3701 is the major metabolite of chlorothalonil. In acute toxicity
testing, it is placed in Toxicity Category II for the oral route of exposure.
There is no evidence of carcinogenicity for the SDS-3701 metabolite.
Hexachlorobenzene (HCB) is an impurity present in chlorothalonil and
other pesticide products. It is classified as a B2 carcinogen.
Dietary Exposure and Risk
Chlorothalonil in Food: To estimate acute dietary risk from food,
exposure estimates for chlorothalonil and the metabolite SDS-3701were
compared to a LOEL of 175 mg/kg/day, based on cell proliferative response in
rats. Because a LOEL was used for the assessment instead of a NOEL, an
extra safety factor of 3 was added, and the safety margin is 300 instead of 100.
The acute dietary risk analysis for chlorothalonil and SDS-3701-combined-
indicates that there are adequate margins of exposure for the general
population and the most highly exposed population subgroups.
To estimate chronic non-cancer dietary risk from food, dietary exposure
estimates for chlorothalonil and SDS-3701 were compared to the RfD for
chlorothalonil, 0.02 mg/kg/day, derived from a 2-year feeding study in rats
which exhibited kidney and stomach effects. An uncertainty factor of 100 was
applied to account for intraspecies variability and interspecies extrapolation.
Dietary exposure was estimated from tolerance level residues adjusted with
information on how much of each crop is actually treated with chlorothalonil.
Risk estimates indicate that chronic non-cancer dietary risk from exposure to
chlorothalonil and SDS-3701 combined is not of concern for the general
population and the most highly exposed population subgroup.
Chlorothalonil dietary cancer risk estimates are calculated from both the
Qi* for chlorothalonil (0.00766 [mg/kg/day]"1, based on tumor rates in female
rats), resulting in a measure of cancer probability, and the NOEL (1.5
mg/kg/day, derived from a cell proliferation study in mice), resulting in a
margin-of-exposure measure of risk. Risk management decisions were based
on the Q,* formula, as the non-linear mechanism associated with the MOE
approach has not been definitively validated and policy on determining an
adequately protective MOE for cancer risk has not been established. Cancer
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risk from food was estimated to be 1.2 x 10~6. This figure is at a level which
the Agency considers negligible for excess lifetime cancer risk estimates.
Chlorothalonil in water: In estimating acute and chronic non-cancer
drinking water risks from groundwater, concentrations of chlorothalonil were
estimated as the combined concentrations of its metabolites as found in an area
of vulnerability to groundwater contamination. Chlorothalonil itself was not
found in mis area, and found infrequently in groundwater from other areas.
Because chlorothalonil was not generally found in groundwater, and because
the metabolites which were found are not known to be carcinogenic, cancer
risk for drinking water from groundwater sources was not assessed.
For acute risk from groundwater sources of drinking water, the highest
combined metabolite concentration in groundwater was compared to the,a.pute
dietary exposure LOEL of 175 mg/kg/day. This acute risk drinking water
assessment for groundwater indicated that there are adequate margins of
exposure for the general population and the most highly exposed population
subgroups.
For chronic non-cancer risk from groundwater sources of drinking
water, the highest combined metabolite concentration in groundwater was
compared to the compared to the RfD of 0.02 mg/kg/day. This assessment
indicates that chronic non-cancer drinking water risk from groundwater is not
of concern for the general population and the most highly exposed population
subgroup.
Chlorothalonil has been detected in surface water, and acute, chronic
non-cancer, and cancer drinking water risks were based on the maximum
concentration detected in surface water monitoring in southern Florida.
For acute risk from surface water sources of drinking water, the
maximum detected concentration in surface water was compared to the acute
dietary exposure LOEL of 175 mg/kg/day. This acute risk drinking water
assessment for surface water indicates that there are adequate margins of
exposure for the general population and the most highly exposed population
subgroup.
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For chronic non-cancer risk from surface water sources of drinking
water, the maximum detected concentration in surface water was compared to
the compared to the'RfD of 0.02 mg/kg/day. This assessment indicates that
chronic non-cancer drinking water risk from groundwater is not of concern for
the general population and the most highly exposed population subgroup.
Chlorothalonil dietary cancer risk estimates were based on both the Q,*
for chlorothalonil and the NOEL from the cell proliferation study. As noted
above, risk management decisions were based on the Q,* formula. Using the
Q]*, drinking water cancer risk from surface water is estimated to be well
below the level which the Agency considers negligible for excess life time
cancer risk estimates.
SDS-3701: The acute and chronic non-cancer dietary xislo assessments
for SDS-3701 in food are folded into the assessments for chlorothalonil. Acute
and chronic non-cancer dietary risks for SDS-3701 in groundwater are
addressed through the use of a maximum combined metabolite concentration as
a surrogate exposure for chlorothalonil concentrations. Surface water drinking
water risks were not estimated for SDS-3701 due to a lack of data. SDS-3701
is not carcinogenic, so dietary cancer risks for food and drinking water
were not assessed.
HCB from chlorothalonil in food: There is no acute endpoint associated
with HCB, so acute dietary risks were not assessed. Chronic non-cancer
dietary risk from food was estimated by comparing the RfD for HCB (0.0008
mg/kg/day, based on liver effects in a 130-week rat feeding study) to dietary
exposure. In the absence of HCB monitoring data, dietary exposure was
estimated from tolerance level residues of chlorothalonil adjusted with
information on how much of each crop is actually treated with chlorothalonil
and further adjusted for a maximum level of 0.05% HCB in the formulation.
Risk estimates for the overall U.S. population and the most highly exposed
subgrpup indicate that chronic non-cancer dietary risk from exposure to HCB
in chlorothalonil is not of concern for the general population and the most
highly exposed population subgroup.
Dietary cancer risk from food for HCB in chlorothalonil was based on
the Q,* for HCB and the dietary exposure estimate described above. The Q,*
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for HCB, 1.02 (mg/kg/day)"1, is based on tumor incidence in hamsters and rats.
The dietary cancer risk estimate from food for HCB in chlorothalonil is below
the level which the Agency considers negligible for excess life time cancer risk
estimates.
HCB from chlorothalonil in drinking jwater: Estimates of the drinking
water risk for HCB originating in chlorothalonil were not calculated for acute
risk because HCB has no acute risk endpoint. Chronic non-cancer drinking
water risk for HCB from chlorothalonil in groundwater was estimated by
assuming HCB is present in drinking water at 0.05% of the maximum
combined metabolite concentration. The estimated exposures were compared
to the RfD of 0.0008 mg/kg/day. This assessment indicates that chronic non-
cancer drinking water risk from groundwater for HCB originating in
chlorothalonil is not of concern for the general population and the most highly
exposed population subgroup. Drinking water cancer risk for HCB from
chlorothalonil in groundwater was not calculated because the metabolites
represented by the maximum combined metabolite concentration in
groundwater are not known to be carcinogenic.
Chronic non-cancer drinking water risks for HCB from chlorothalonil in
surface water were estimated by assuming HCB is present in drinking water at
0.05% of the maximum concentration observed in surface water. The
estimated exposures were compared to the RfD of 0.0008 mg/kg/day. This
assessment indicates that chronic non-cancer drinking water risk from surface
water for HCB originating in chlorothalonil is not of concern for the general
population and the most highly exposed population subgroup.
For estimating drinlcing water cancer risk for HCB originating in
chlorothalonil from surface water, the estimated concentration of HCB (0.05%
of the maximum chlorothalonil concentration observed in surface water) was
compared to the cancer potency factor for HCB, 1.02 (mg/kg/day)"1. The
estimated drinlcing water cancer risk for HCB originating in chlorothalonil from
surface water is well below the level considered by the Agency to be negligible
for excess lifetime risk.
HCB from all pesticidal sources in the diet: HCB is present in
chlorothalonil and at least nine other pesticides. Four of these contribute
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significant amounts of HCB and pentachlorobenzene (a related contaminant
that is assumed to be toxicologically equivalent to HCB) to the diet:
chlorothalonil, PCNB, picloram, and dacthal. The Agency assessed the
aggregate dietary cancer risks (from food and water) associated with these
pesticides. The assessment is limited in particular by the lack of data on HCB
levels in food and water. Food exposures were generally estimated by applying
maximum contamination levels of HCB in product formulations to observed
levels of parent compound residues in food. Aggregate dietary cancer risk for
HCB and PCS in food was based on these exposure estimates and on the Q,*
for HCB. The estimated dietary cancer risk for food from HCB in pesticides is
1.8 x 10~6, which is at the lower end of range of concern for dietary cancer risk.
A quantitative aggregate assessment for HCB and PCB in drinking water
was not conducted because data are limited and observed levels are very low.
The Agency concluded that drinking water risk estimates from HCB in
pesticides did not exceed the Agency's level of concern
Occupational and Residential Exposure and Risk
Handlers: Occupational and residential risks were estimated for mixers,
loaders, applicators, and flaggers (occupational only) of chlorothalonil for
short- and intermediate term inhalation and dermal exposures. A dermal
NOEL of 600 mg/kg/day was selected for assessing these risks from a 21-day
study in the rat. The inhalation NOEL of 2 mg/kg/day was selected from a 2-
year feeding study in rats. Carcinogenic risks were also assessed for handlers,
based on the Qj*. The MOE approach was not used to estimate cancer risk for
handlers because exposures to handlers were judged not to chronic.
Occupational and residential handler short- and intermediate term risk
estimates were below an MOE of 100 for:
• wettable powder formulations (inhalation exposure),
• granulars applied with tractor drawn spreaders to turf (inhalation
^exposure),
• specialty air-assisted equipment on golf courses (dermal exposure),
• residential applicators using certain equipment on turf (dermal and some
inhalation exposure), and
• professional painters using sprayers (inhalation exposures).
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Occupational and residential cancer risk estimates (using the Q,*)
exceeded levels which typically are of concern for:
• wettable powder formulations, and
residential applicators using certain equipment on turf.
Handler risks from exposure to HCB in chlorothalonil were
approximated using a high-end exposure estimate for chlorothalonil and
adjusted for the maximum allowable concentration of HCB in chlorothalonil.
By this approach, handler risks from HCB were determined to be below the
levels the Agency typcially identifies as being of concern.
Po^t-Application: The Agency has assessed the interim restricted entry
interval (REI) for chlorothalonil of 48 hours. The Agency now believes that a
12-hour REI is appropriate if additional measures are taken to protect the eyes
for seven days after chlorothalonil is applied.
Significant post-application exposures were thought to be possible in a
number of settings including workers who maintain and harvest horticultural
crops and residents exposed to treated lawns. Short- and intermediate-term
post-application risks for chlorothalonil were based on the same dermal NOEL
as handler risks. Post-application inhalation exposures were determined not be
significant. Carcinogenic risk was estimated using the Q,* approach.
Exposures to workers who reenter treated areas to perform hand-labor tasks
on cut flowers may be chronic, so cancer risk for these workers also was
calculated using the MOE approach.
Short- and intermediate-term post-application risks were below the MOE
of 100 for two scenarios:
• i workers reentering treated sodfarm areas to cut, roll, and harvest sod
• ^toddlers in dermal contact with treated turf.
None of post-application cancer risk estimates based on the Q,* showed
excess cancer risk. For workers reentering treated greenhouses aad fields
where flowers and potted ornamentals are grown for hand-labor tasks (cutting,
bundling, transplanting, and pruning), cancer risk estimates based on the MOE
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approach are likely to exceed the standards which will be established by the
Agency for acceptable cancer MOEs. This assessment is predicated on the
potential for chronic exposures to workers in these areas, an assumption which
•— - the Agency is requiring data to confirm. Although the Agency has not
confirmed that the non-linear mechanism on which the cancer MOE approach
is based is valid, and has not identified an "acceptable" MOE for cancer, past
discussions of an acceptable level have focused on MOEs of 100 or greater.
An MOE of less than 100, as has been calculated for these workers, is likely to
be of concern.
Environmental Environmental Fate
Assessment Chlorothalonil is resistant to hydrolysis, photolysis, and volatilization,
and only moderately susceptible to degradation in soil under aerobic
conditions. Chlorothalonil is somewhat persistent in water when microbial
activity is limited and hydrological residence times are long. Aerobic aquatic
metabolism half-lives from two hours to eight days have been reported under
various conditions, but the two-hour half-life is associated with experimental
conditions which correspond more closely to aerated and agitated wastewater
treatment than to natural systems. Even so, the shorter half-life was used as a
low-end assessment parameter in the RED.
Chlorothalonil has limited potential to reach groundwater, and where it
has been detected in groundwater, concentrations have been low and often
attributed to atypical sources. Degradates of Chlorothalonil have been found in
groundwater. Chlorothalonil can contaminate surface water via spray drift or
through runoff and erosion. Chlorothalonil can be dissolved in runoff and
adsorbed to sediment in the runoff.
The major degradate of Chlorothalonil in the soil under aerobic
conditions is SDS-3701. SDS-3701 appears to be more persistent and mobile
than Qhlorothalonil. Consequently, substantial amounts of SDS-3701 may be
available for runoff for longer periods than Chlorothalonil and SDS-3701 may
be more persistent in water/sediment systems than Chlorothalonil.
The bioaccumulation potential of Chlorothalonil is low, although there is
some potential for the bioaccumulation of Chlorothalonil degradates in oysters.
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Ecological Effects
Chiorothalonil is "practically non-toxic" to avian species on an acute oral
and subacute dietary basis, and effects on avian reproduction have been
observed at a dose of 5 ppb. Qilorothalonil is "practically non-toxic" to small
mammals on an acute oral basis, and developmental effects were observed in
rats at 8 ppb. Chlorothalonil is "relatively non-toxic" to honey bees, and "very
highly toxic" to fish. The toxicity of formulated chlorothalonil products to fish
is similar but may be affected by other constituents in the products. Fathead
minnow hatching success and survival are affected at concentrations of
chlorothalonil between 3 and 6.5 ppb. Chlorothalonil is "very highly toxic" or
"highly toxic" to aquatic invertebrates, and a formulated chlorothalonil product
showed similar results. Chlorothalonil can affect aquatic invertebrate
reproduction between 39 and 79 ppb.
' • • • ..••..'••..... . > '.-TA>>'-
SDS-3701 is more toxic to birds man the parent on an acute oral and
subacute dietary basis; avian reproduction in birds could be affected at levels
above 50 ppm. SDS-3701 is "moderately toxic" to small mammals on an acute
oral basis. SDS-3701 is "slightly toxic" to bluegill and D. magna, and
significantly less toxic than parent chlorothalonil in both cases.
At an application rate of 16 Ib chlorothalonil/A, the most sensitive
terrestrial plant species (onions) showed a non-statistically significant negative
response in seed germination/seedling emergence/vegetative vigor. Testing Jn
a freshwater green alga exhibited an EC50 of 190 ppb and a NOEC of 50 ppb.
Additional Tier 2 testing for aquatic species is required.
Ecological Effects Risk Assessment
Levels of concern, especially for aquatic organisms, were exceeded for a
number of crops, including peanuts and potatoes. The turf use can also be high
risk. In addition, many chlorothalonil labels do riot provide specific application
rate niaximums. Marine/estuarine mollusks are particularly at risk.
>
Risk Mitigation To address the carcinogenic dietary risk from HCB contributed by
chlorothalonil, the registrants of chlorothalonil have agreed to reduce the level
of HCB in chlorothalonil technical and manufacturing-use products to 40 ppm
by January 1, 2003. This is the lowest level that has been shown to be
technologically feasible for chlorothalonil. The registrants have agreed to
D
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certify this final level and several interim levels. Failure to achieve any
milestone will result in a suspension of manufacture or import of the subject
products until such time as the target level is achieved. If the target level is not
• achieved by January 1, 2008, the subject registrations will be immediately
canceled without opportunity for appeal. The registrants have also agreed to
maintain approximately historic levels of production and import of
chlorothalonil manufacturing-use product during the period of HCB reduction
to assure that chlorothalonil with higher concentrations of HCB will not be
stockpiled and formulated. The schedule for interim reductions in HCB
content is different for product destined to be added to paint and all other
products in recognition of pigmentation problems which may be associated
with purification, but the final date and contamination level are the same for
both.
To protect occupational handlers of pesticides containing chlorothalonil,
the registrants have agreed that:
• wettable powder formulations must be packaged in water soluble bags or
labeled for use only in closed mixing/loading systems,
• handlers of granular formulations applied with tractor drawn spreaders to
turf must wear dust masks,
• applicators using specialty air-assisted application equipment on turf
must wear chemical-resistant gloves,
• painters using airless sprayers should wear respirators,
• workers who reenter treated areas after the restricted-entry interval but
within 7 days of treatment must receive special notification about eye
irritation hazards and have access to on-site eye-flushing equipment,
• handlers of wettable powder, liquid flowable, and dry flowable
formulations, and those using hand-held equipment (such as backpack
sprayers ) must wear gloves, and
• handlers in enclosed spaces (greenhouses) must wear respirators.
To protect residential handlers of pesticides containing chlorotlialonil and
children who are exposed to chlorothalonil after application of chlorothalonil to
home lawns, the registrants have agreed that products containing chlorothalonil
are prohibited for use on home lawns.
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To protect reentry workers who cut, roll, and harvest sod treated with
chlorothalonil, the registrants have agreed that sod treated with chlorothalonil
must be harvested, rolled, and palletized mechanically.
To address risk concerns and uncertainties about exposure from
specialty products, the registrants agreed that:
• chlorothalonil mildewicidal additives must be labeled to prohibit sale
over-the-counter at retail outlets. The registrants have committed to
working with the Agency to develop measures for the protection of
employees of paint sales outlets who mix mildewicidal additives into
paint for sale.
• the in-container preservative use of chlorothalonil will be discontinued.
Additionally, to address risk concerns associated with a smoke generator""
formulation, such products are designated as Restricted Use Pesticides, and
restrictions and labeling_ requirements designed to reduce handler and post-
application exposure are specified.
Additional Data
Required
To protect wildlife, the registrants have agreed to reduce individual and
seasonal maximum application rates for many use sites. For a table of these
rates, refer to Chapter IV of the chlorothalonil RED. In addition, untreated
buffers are required between estuarine/marine water bodies and agricultural
crops treated with chlorothalonil-at least 150 feet for aerial and air-blast
applications and 25 feet for ground applications.
The generic data base supporting the reregistration of chlorothalonil has
been reviewed and determined to be substantially complete. The following
additional data are being required:
72-3 (d-f) Acute marine/estuarine fish, mollusk, and shrimp
72-4(a) Fish early life stage
123-2 Aquatic plant growth
13 2-1 (a) Foliar residue dissipation
133-3 Post-application dermal passive dosimetry exposure
133-4 Post-application inhalation passive dosimetry exposure
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(Guidelines 133-3 and 1=33-4 are reserved pending review of agricultural and
residential post-application/reentry exposure data currently being developed by
the Agricultural Reentry Task Force and Outdoor Residential Exposure Task
Force.)
Residue data have been submitted in support of establishing a tolerance
on sweet corn forage and are currently under review. The review of these data
should not delay a reregistration eligibility decision for chlorothalonil, but
additional storage stability information is required. This information is
expected to confirm that chlorothajonil residues of concern are stable under
frozen storage.
A special study is being required to assess residues of SDS-3701 on
foliage which serves as a .wildlife food source. Data on1use.,p.atterns .of „„,..
chlorothalonil on cut flowers, particularly those grown in greenhouses, are
required to determine whether post-application exposure should be considered
chronic exposure. Exposure data for handlers involved in wood pressure
treatment are required. Data are also required on exposures to occupational
and residential handlers associated with the application of wood preservative
products and people who are exposed to pressure-treated wood when they cut
and build with it.
Product Labeling All chlorothalonil end-use products must comply with EPA's current
Changes Required pesticide product labeling requirements and with those labeling requirements
imposed in the chlorothalonil RED. For a comprehensive list of labeling
requirements, please see Section V. of the chlorothalonil RED document.
Regulatory
Conclusion
For More
Information
The Agency has determined that chlorothalonil products, labeled and
used as specified in the RED, will not pose unreasonable risks to humans or the
environment.
EPA is requesting public comments on the RED document for
chlorothalonil during a 60-day time period, as announced in a Notice of
Availability published in the Federal Register. To obtain a copy of the RED
document or to submit written comments, please contact the Pesticide Docket,
Public Response and Program Resources Branch, Field Operations Division
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(7506C)? Office of Pesticide Programs (OPP), US EPA, Washington, DC
20460, telephone 703-305-5805.
Electronic copies of the RED and this fact sheet are available on the
Internet. See http://www.epa.gov/REDs.
Printed copies of the RED and fact sheet can be obtained from EPA's
National Center for Environmental Publications and Information
(EPA/NCEPI), PO Box 42419, Cincinnati, OH" 45242-0419, telephone 513-
489-8190, fax 513-489-8695.
\ ' .
Following the comment period, the chlorothalonil RED document also
will be available from the National Technical Information Service (NTIS),
5285 Port Royal Road, Springfield, VA 22161, telephone 703-605-6000."
For more information about EPA's pesticide reregistration program, the
chlorothalonil RED, or reregistration of individual products containing
chlorothalonil please contact the Special Review and Reregistration Division
(7508C), OPP, US EPA, Washington, DC 20460, telephone 703-308-8000.
For information about the health effects of pesticides, or for assistance in
recognizing and managing pesticide poisoning symptoms, please contact the
National Pesticide Telecommunications Network (NPTN). Call toll-free 1-
800-858-7378, between 6:30 am and 4:30 pm Pacific Time, Monday through
Saturday. Their internet~address is: ace.orst.edu/info/nptn.
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