United States Office of Prevention, Pesticides EPA-738-R-00-001
Environmental Protection And Toxic Substances March 2000
Agency (7508C)
SEPA Status of Chemicals
in Special Review
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STATUS OF CHEMICALS
IN SPECIAL REVIEW
MARCH 2000
Special Review and Reregistration Division (7508C)
Office of Pesticide Programs
U. S. Environmental Protection Agency
Washington, D.C. 20460
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STATUS OF CHEMICALS IN SPECIAL REVIEW
TABLE OF CONTENTS
Chapter 1 INTRODUCTION 1
Management Directory 3
General Information 4
Chapter2 SPECIAL REVIEW 5
The Special Review Process 7
Special Review Decision Dates at a Glance 11
Reference Lists of Pesticides in Special Review 15
Status of Individual Pesticide Reviews 20
1. Special Reviews in Process 20
2. Special Reviews Completed 26
3. Final Determinations on Pre-Special Reviews/Deferred to Reregistration .... 46
4. Final Actions/Voluntary Cancellations 51
5. Cancellations Issued Prior to RPAR/Special Review Process 58
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CHAPTER ONE
INTRODUCTION
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SPECIAL REVIEW AND REREGISTRATION DIVISION
OFFICE OF PESTICIDE PROGRAMS, EPA
MANAGEMENT DIRECTORY
Lois A. Rossi, Director (703) 308-8000
Jack Housenger, Associate Director (703) 308-8000
Susan Lewis, Chief (703) 308-8009
Reregistration Branch I
Kathy Monk, Chief (703) 308-8071
Reregistration Branch II
Betty Shackleford, Chief (703) 308-8062
Reregistration Branch III
Linda Propst, Chief (703) 308-8165
Product Reregistration Branch
Robert McNally, Chief (703) 308-8085
Special Review Branch
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PURPOSE:
GENERAL INFORMATION
COMMENTS:
"Status of Chemicals in Special Review" describes
the status of pesticides that are now undergoing or have
completed the pesticide Special Review program
mandated by the federal pesticide law, FIFRA (the Federal
Insecticide, Fungicide, and Rodenticide Act), and
administered by EPA.
AVAILABILITY:
Electronic copies of the 1998 "Status of Chemicals
in Special Review" and many other related pesticide
regulatory documents are available on the Internet, on the
EPA Office of Pesticide Programs home page. Please
see:
http://www.epa.gov/pesticides
Printed copies of "Status of Chemicals in Special
Review" are available from:
National Center for Environmental Publications and
Information (EPA/NCEPI)
P.O. Box42419
Cincinnati, Ohio 45242-2419
Telephone: (800) 490-9198
Fax: (513)489-8695
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
Telephone: (703) 487-4650
Fax:(703)321-8547
The "Status of Chemicals in Special Review" is
updated approximately once a year by EPA's Office of
Pesticide Programs. Your comments and suggestions are
welcome. Please contact:
"Status of Chemicals in Special Review"
Special Review and Reregistration Division
(7508W)
Office of Pesticide Programs
Environmental Protection Agency
401 M. St., SW
Washington, D.C. 20460
Telephone: (703) 308-8000
Fax: (703) 308-8005
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CHAPTER TWO
SPECIAL REVIEW
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CHAPTER TWO: SPECIAL REVIEW
This Chapter is organized as follows. The first section
explains the Special Review process, including the criteria that EPA
uses to initiate a Special Review, the steps the Agency takes in
conducting a Special Review, and risk reduction alternatives to the
conventional Special Review process. The next section provides an
"At a Glance" summary of the dates when Special Review decision
documents were published in the Federal Register. The third section
is a comprehensive reference list of all chemicals which have been or
are currently in the Special Review program. The chemicals are in
alphabetical order within categories of Special Review. The last
section lists the chemicals in identical sequence and, in addition,
presents the details of Special Review criteria met or exceeded, and
outcomes of the reviews.
THE SPECIAL REVIEW PROCESS
The Special Review process is set in motion when EPA has
reason to believe that the use of a pesticide may result in
unreasonable adverse effects to people or the environment. The
criteria for initiating a Special Review, set forth in 40 CFR Part 154.7,
are:
1. Acute toxicity to humans or domestic animals.
2. Potential chronic or delayed toxic effects in humans.
3. Potential hazards to non-target organisms.
4. Risk to the continued existence of any threatened or
endangered species.
5. Risk of destruction or other adverse modification of a critical
habitat of any threatened or endangered species.
6. Any other adverse effect to humans or the environment which
may outweigh the benefits that justify initial or continued
registration.
As required by the regulations, the producers of a pesticide, or
"registrants," receive private notification that the Agency is considering
issuing a Notice of Special Review. This private notification
commences the pre-Special Review phase of the process. The
registrant has 30 days to dispute the validity of the Agency's concerns.
If, after private notification to the registrants, the Agency
tentatively determines that use of the pesticide does not pose a
significant risk, a Federal Register (FR) notice is issued which
explains the reasons for the Agency's decision. This notice also
announces the availability of the public docket, which includes the
pre-Special Review notification and all written information received in
response to the notification. The FR notice also solicits public
comment, after which the Agency makes a final decision on whether
to initiate a Special Review.
If the Agency determines that a significant risk may be
associated with a pesticide, a Notice of Special Review (Position
Document 1) will be published in the FR. This notice describes the
Special Review criterion of concern, the assumptions and data used
in the analysis, and the strength of the conclusions. The notice will
also announce the availability of the pre-Special Review public docket,
solicit public comment, and request additional information on the
pesticide.
After issuance of the Notice of Special Review, the Agency may
meet with interested parties to discuss the risk concerns and available
options to reduce the potential risks to health or the environment.
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Commencement of the Special Review process is accompanied by an
Agency-conducted, comprehensive risk/benefit analysis of each use
of the pesticide subject to Special Review. Potential risks are
evaluated by considering factors such as: 1) adverse effects to health
or the environment; 2) magnitude of exposure of humans and other
non-target organisms; and 3) size of the population at risk. Benefits
of use are evaluated by assessing the availability, efficacy, and cost
of alternative control methods, and impact on users, consumers, and
other parties (except the registrant) if the pesticide is cancelled.
If, after issuance of a Position Document 1, the risks are
determined to be lower than originally believed and acceptable, the
Agency may decide that continuation of the Special Review is not
warranted. This new risk determination may result from further
in-depth risk/benefit analyses or risk reduction actions taken on behalf
of the registrants. In these instances after a Position Document 1 has
been issued but prior to issuing a Position Document 2/3, the Agency
ends the Special Review by publishing a Notice of Decision to
Terminate the Special Review (Position Document 2) in the FR.
If the Special Review is not concluded by publishing a Position
Document 2, a Notice of Preliminary Determination (Position
Document 2/3) is then published in the FR for public comment. If the
registrants voluntarily amend their registrations in a manner which
would reduce the risks of the pesticide use to acceptable levels, the
notice explains the Agency's previous risk concerns and voluntary
resolutions made by the registrants to alleviate potential risks. If the
registrants do not voluntarily amend the conditions of registrations in
order to reduce risks to an acceptable level, the notice would include
the regulatory measures the Agency believes are required to reduce
risks of the pesticide use(s) to acceptable levels and a proposed
notice of intent to cancel, deny, or reclassify any registrations which
do not comply with these measures.
The Preliminary Determination is then submitted to the FIFRA
Scientific Advisory Panel (SAP) for comment on the Agency's
scientific rationale. At the same time, the Agency submits the
proposed notice to the United States Department of Agriculture
(USDA) for comment, especially on the benefits issues and agricultural
impacts.
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After evaluating all comments received from the USDA, the SAP,
and the public on the proposed action, the Agency will modify the
proposal where appropriate prior to issuance as a final action. A
Notice of Final Determination (Position Document 4) is published in the
FR. along with a Notice of Intent to Cancel, Deny, or Reclassify
Registration, if required to implement the determination. Any such
notice becomes effective by operation of law, unless the registrant
makes the necessary corrections or a hearing is timely requested by
a person adversely affected by the notice.
The ultimate goal of the Special Review process is to reduce the
risks posed by a pesticide to an acceptable level while taking into
consideration the benefits provided by the use of that pesticide.
Several alternatives to the conventional process are available that also
achieve risk reduction but in a more accelerated manner. They
include:
Position Document 1/2/3 A Position Document 1/2/3 may be
used when the Agency has sufficient information at the outset of a
Special Review to fully assess both the risks and benefits. The
Position Document 1/2/3 bypasses the Position Document 1 stage
and provides a full discussion of the risks, benefits, and proposed
decision at the same time.
Notice of Intent to Cancel (NOIC) - Under FIFRA section 6(b),
the Agency may issue a NOIC when it has been determined that a
pesticide poses unreasonable adverse effects. Those uses or
registrations posing the risks are cancelled and removed from the
market.
Suspension Order/Emergency Suspension Order- Under FIFRA
section 6(b), the Agency may issue a suspension order or emergency
suspension order to quickly remove a pesticide from the market when
it poses an imminent hazard.
Negotiated Settlements - At any time, a registrant may reach an
agreement with the Agency to modify the terms and conditions of a
pesticide registration, in order to reduce risk to an acceptable level.
The modifications may include, but are not limited to, cancelling uses,
changing use patterns, changing application methods and/or rates,
and imposing protective measures.
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These alternatives are not intended to replace the conventional,
intensive Special Review process. In many cases, they are used
concurrently with the conventional process to achieve expeditious risk
reduction of critical concerns while the overall review continues. In
other cases, the alternative processes are used to quickly reduce risk
concerns associated with the use of a pesticide before it is placed in
the formal Special Review process.
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SPECIAL REVIEW DECISION DATES AT A GLANCE
Date published in Federal Register
Chemical
1,3-Dichloropropene
2,4,5-T/Silvex
2,4,5-Trichlorophenol (TCP)
2,4-D [also 2,4-DB and 2,4-DP]1
Acrylonitrile (3 products cancelled)
Alachlor
Aldicarb
Aldrin
Amitraz
Amitrole
Arsenic Trioxide (some uses)
Atrazine
Benomyl
Benzene
BHC
Cacodylic Acid and Salts
Cadmium
Captafol
Captan
Carbaryl
Carbofuran (granular)
Carbon Tetrachloride
Chloranil
Chlordane
Chlordane/Heptachlor
Chlordecone (Kepone)
Chlordimeform
Chlorinated Isocyanurates
Chlorobenzilate
Chloroform
Proposed
Pre-Special Notice of conclusion of
Review Special Review Special Review
terminated PD1 PD2
10/08/86 01/12/00
04/21/78
08/02/78
03/23/88 (proposed)
01/09/85
07/11/84
04/06/77
06/15/84 01/22/93
11/23/94
12/06/77
07/31/85
05/12/82
1 0/26/77
12/09/84 08/31/88
08/18/80
12/12/80
10/16/85
10/15/80
05/20/88
05/26/76
04/06/76 01/05/83
Proposed
regulatory
position
PD2/3
07/17/79
10/08/86
06/29/88
01/12/79
08/30/79
10/10/86
06/21/85
01/25/89
07/11/78
Final
regulatory
action
12/13/79 (PD4)
04/29/87 (PD 2/3/4)
06/1 9/78 (6(f))2
12/31 787 (PD 4)
10/18/74
06/07/79 (PD 4)
09/13/77 (6(f))
1 0/20/82 (PD 4)
07/21/78 (6(f))
04/10/91 (PD4)
02/24/89 (PD 4)
12/11/91 (PD4)
11/12/86 (6(f))
01/19/77 (6(f))
04/08/88
04/08/88
07/27/77
02/08/89 (6(f))
02/1 3/79 (PD 4)
The Agency issued a Federal Register Notice proposing not to initiate the Special Review. A final decision is yet to be made.
Publication of a 6(f) Notice of Receipt of Request to Cancel Registrations may eliminate the need for continuance of a Special Review action if all of the uses posing the risks of concern are voluntarily
cancelled by the registrant. The Agency will grant approval for the cancellation request and therefore, preclude the need for an intensive review since cancellation of the uses will eliminate the risks. This type of
action can occur prior to issuance of a PD1 or Grassley-Allen notification.
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SPECIAL REVIEW DECISION DATES AT A GLANCE
Date published in Federal Register
Chemical
Coal Tar and Creosote (non-wood use)
Copper Acetoarsenite
Copper Arsenate
Creosote (wood use)
Cyanazine
Cyanazine
Cyhexatin
Daminozide (food use)
Daminozide (non-food use)
DBCP (Dibromochloropropane)
ODD (TDE) (Dichlorodiphenyl dichloroethane)
DDT (Dichlorodiphenyl trichloroethane)
Diallate
Diazinon
Dichlorvos (DDVP)
Dicofol
Dieldrin
Diflubenzuron (Dimilin)
Dimethoate
Dinocap
Dinoseb
EBDCs
EBDCs
Endrin
EPN (Ethyl (p-nitrophenyl)thiobenzene phosphonate)
Erbon
Ethalfluralin
Ethylene Dibromide (EDB)
Proposed
Pre-Special Notice of conclusion of
Review Special Review Special Review
terminated PD1 PD2
10/18/78
10/18/78
04/1 0/85
11/23/94 03/01/96
09/25/87
07/1 8/84
07/1 8/84
09/22/77
07/07/72
05/31/77
01/15/86
02/24/88
03/21/84
03/26/79
09/12/77
01/09/85
08/1 0/77
07/1 7/87
07/27/76
09/1 9/79 07/24/87
01/04/84
12/14/77
Proposed
regulatory
position
PD2/3
08/22/84
02/19/81
01/17/87
05/24/89
05/24/89
06/09/80
01/15/86
09/28/95
10/10/84
11/19/79
1 0/29/86
12/20/89
11/02/78
01/04/84
12/10/81
Final
regulatory
action
1 0/16/85 (PD 4)
04/07/77
04/07/77
07/1 3/84 (PD 4)
01/1 3/88 (PD 4)
07/25/96
1 1/14/89 (PD 4)
1 0/08/92 (PD 4)
01/09/85
03/18/71
06/23/82 (PD 4)
10/01 786 (PD 4)
05/29/86 (PD 4)
10/18/74
01/19/81 (PD4)
02/06/89 (PD 4)
10/14/86
10/27/82
02/1 3/92 (PD 4)
07/25/79 (PD 4)
10/04/80
01/04/84 (PD 4)
1 0/07/83 (PD 4)
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SPECIAL REVIEW DECISION DATES AT A GLANCE
Date published in Federal Register
Chemical
Ethylene Oxide
Fluoroacetamide (Compound 1081)
Goal (Oxyfluorfen)
Heptachlor
Inorganic Arsenicals (some non-wood uses)
Inorganic Arsenicals (arsenic acid)
Inorganic Arsenicals (wood use)
Lindane
Lindane
Linuron
Maleic Hydrazide
Mercury (indoor paint uses)
Mercury (exterior paint uses)
Metam-Sodium
Methanearsonates
Mevinphos
Calcium Acid Methanearsonate (CAMA),
Monosodium Methanearsonate (MSMA), Disodium
Methanearsonate (DMSA))
Mi rex
Monocrotophos
Monuron
Naled
Nitrofen (TOK)
OBPA (1 0, 1 0'-Oxybisphenoxarsine)
OMPA (Octamethylpyrophosphoramide)
Oxydemeton-methyl
Paraquat Dichloride
Pre-Special
Review
terminated
03/1 8/94 (Proposed)
06/28/83
06/28/83
06/28/83
06/28/83
07/15/88
06/30/83
09/15/83
04/09/79
10/23/82
Proposed
Notice of conclusion of
Special Review Special Review
PD1 PD2
01/27/78
12/01/76 02/28/80
10/18/78
10/18/78
10/18/78
02/18/77
09/26/84 01/27/89
10/28/77 01/05/82
1 0/05/87
Proposed
regulatory Final
position regulatory
PD2/3 action
06/23/82
04/08/88
01/02/87 06/30/88 (PD 4)
10/07/91 1 2/08/93 (PD 4)
02/19/81 07/1 3/84 (PD 4)
07/03/80 10/1 9/83 (PD 4)
07/26/95
06/29/90 (6(f))
07/10/91 (6(f))
09/21/94 (NOIC)
04/05/95 (NOIC)
12/29/76
08/16/77 (6(f))
05/28/76 (6(f))
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SPECIAL REVIEW DECISION DATES AT A GLANCE
Date published in Federal Register
Chemical
Parathion
PCNB (Pentachloronitrobenzene)
Pentachlorophenol (non-wood use)
Pentachlorophenol (wood use)
Perthane
Phenarsazine Chloride
Piperonyl Butoxide
Pronamide
Propoxur
Ronnel
Rotenone
S,S,S-Tributyl Phosphorotrithioate
Safrole
Simazine
Simazine (swimming pool uses)
Sodium Arsenite (fungicide)
Sodium Fluoroactetate (Compound 1080)
Sporicidin
Strobane
Strychnine/Strychnine Sulfate
Terbutryn
Thiophanate-Methyl
Toxaphene
TPTH (Triphenyltin hydroxide)
Triallate
Tributyl Phosphorotrithioite
Tributyltins (antifoulant use)
Trichlorfon
Trifluralin
Trysben
Wipeout
Proposed
Pre-Special Notice of conclusion of
Review Special Review Special Review
terminated PD1 PD2
10/13/77 04/19/82
10/18/78
10/18/78
05/12/82
05/20/77
01/15/95 (Proposed)
07/15/81
05/12/82
11/23/94
10/18/78
12/01/76
01/13/77
05/12/82
12/07/77
05/27/77
01/09/85
12/15/80
05/12/82
01/08/86
06/30/83
Proposed
regulatory
position
PD2/3
12/12/84
02/19/81
01/15/79
01/02/87
11/11/82
11/05/80
10/11/79
1 0/07/87
08/30/79 (PD 1/2/3)
Final
regulatory
action
12/13/91 (6(f))
01/21/87 (PD 4)
07/1 3/84 (PD 4)
06/20/80 (6(f))
11/21/77 (6(f))
1 0/26/79 (PD 4)
02/28/96
01/22/86 (6(f))
06/10/77 (6(f))
07/06/94 (NOIC)
06/19/91 (6(f))
07/31/85 (PD4)
07/14/93 (6(f))
06/28/76 (6(f))
10/19/83 (PD4)
10/20/82 (PD4)
11/29/82 (PD 2/3/4)
10/04/88 (PD4)
08/04/82 (PD4)
02/09/78 (6(f))
08/05/93 (NOIC)
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REFERENCE LISTS OF PESTICIDES IN SPECIAL REVIEW
The five alphabetical lists below (repeated with more detailed information in the next section) provide information as follows:
1. Special Reviews in Process lists chemicals which are now formally in Special Review or which are in pre-Special Review, i.e., chemicals for
which it is public knowledge that they are being considered for formal Special Review.
2. Special Reviews Completed lists chemicals which have Special Review final determinations;
3. Final Determinations on Pre-Special Reviews/Deferred to Reregistration lists chemicals returned to the registration or reregistration
process after a pre-Special Review determination; or for which a determination has been deferred to the reregistration process;
4. Final Actions/Voluntary Cancellations lists chemicals which have had final actions such as voluntary cancellations or Notice of Intent to
Cancel (NOIC) issued prior to any formal Special Review action; and
5. Cancellations Issued Prior to RPAR/Special Review Process lists chemicals cancelled prior to the RPAR and Special Review processes.
RPAR stands for Rebuttable Presumption Against Registration, the name used for Special Review prior to 1986.
1. Special Reviews in Process Page
Aldicarb 20
Atrazine (Triazines) 20
2,4-D [also 2,4-DB and 2,4-DP]1 21
1,3-Dichloropropene (Telone) 21
Dichlorvos (DDVP) 21
Ethylene Oxide 22
Oxydemeton-methyl 23
Propazine (Triazines) 23
Simazine (Triazines) 24
TPTH (Triphenyltin hydroxide) 24
Triazines 25
Tributyltins (antifoulant use) 25
EPA issued a Federal Register Notice proposing not to initiate the Special Review. A final decision is yet to be made and will be based
on the classification of 2,4-D as a category D carcinogen.
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2. Special Reviews Completed Page
Alachlor 26
Amitraz 26
Amitrole 26
Benomyl 27
Cadmium 27
Captafol 27
Captan 28
Carbofuran (granular) 28
Carbon Tetrachloride 29
Chlorobenzilate 29
Chloroform 29
Coal Tar and Creosote (non-wood use) 29
Creosote (wood use) 30
Cyanazine 30
Daminozide 31
DBCP (Dibromochloropropane) 31
Diallate 32
Diazinon 32
Dicofol 33
Dimethoate 33
Dinocap 33
Dinoseb 34
EBDCs (Ethylene bisdithiocarbamates: Maneb, Mancozeb, Metiram, Nabam, Zineb, Amobam) 35
Endrin 36
EPN (Ethyl (p-nitrophenyl)thiobenzene phosphonate) 36
Ethalfluralin 36
Ethylene Dibromide (EDB) 37
Fluoroacetamide 37
Goal (Oxyfluorfen) 38
Inorganic Arsenicals (wood use) 38
Inorganic Arsenicals (non-wood use) 39
Lindane 40
Linuron 40
Maleic Hydrazide 40
PCNB (Pentachloronitrobenzene) 41
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2. Special Reviews Completed (continued) Page
Pentachlorophenol (non-wood use) 41
Pentachlorophenol (wood use) 42
Pronamide 42
Sodium Fluoroacetate (Compound 1080) 42
Strychnine/Strychnine Sulfate 43
2,4,5-T/Silvex 43
Thiophanate-Methyl 44
Toxaphene 44
2,4,5-Trichlorophenol (TCP) 44
Trifluralin 45
3. Final Determinations on Pre-Special Reviews/Deferred to Reregistration
Cacodylic Acid and Salts 46
Carbaryl 46
Chlorinated Isocyanurates 46
Diflubenzuron (Dimilin) 46
Lindane 47
Methanearsonates (includes Amine Methanearsonate, Calcium Acid Methanearsonate (CAMA),
Monosodium Methanearsonate (MSMA), Disodium Methanearsonate (DMSA)) 47
Naled 47
OBPA (10,10-Oxybisphenoxarsine) 47
Paraquat Dichloride 48
Parathion (Ethyl) 48
Phorate 48
Piperonyl Butoxide 48
Propoxur 48
Rotenone 49
Terbufos 49
Terbutryn 49
Triallate 50
S,S,S-Tributyl Phosphorotrithioate 50
Tributyl Phosphorotrithioite 50
Trichlorfon 50
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4. Final Actions/Voluntary Cancellations Page
Acrylonitrile 51
Arsenic Trioxide 51
Benzene 51
BHC 51
Captafol 51
Carbon Tetrachloride 52
Chloranil 52
Chlordane 52
Chlordimeform 52
Copper Acetoarsenite 52
Copper Arsenate 53
Cyhexatin 53
Endrin 53
EPN (Ethyl(p-nitrophenyl)thiobenzene phosphonate) 53
Erbon 53
Heptachlor 54
Mercury 54
Metam-sodium 54
Methazole 54
Mevinphos 55
Monocrotophos 55
Monuron 55
Nitrofen (TOK) 55
OMPA (Octamethylpyrophosphoramide) 55
Parathion (Ethyl) 56
Perthane 56
Phenarsazine Chloride 56
Ronnel 56
Safrole 56
Simazine (Swimming Pool Uses) 56
Sodium Arsenite 57
Sporocidin 57
Strobane 57
Trysben 57
Wipe Out 57
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5. Cancellations Issued Prior to RPAR/Special Review Process Page
Aldrin/Dieldrin .,.,,,,,,,...,,,,,, 58
Chlordane/Heptachlor 58
Chlordecone (Kepone) 58
ODD (IDE) (Dichlorodiphenyl dichloroethane) 58
DDT (Dichlorodiphenyl trichloroethane) 59
Mirex .,.......,'.......,.......,.......,.......,... ....... ....... ....... ...... 59
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1. Special Reviews in Process
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STATUS OF INDIVIDUAL PESTICIDE REVIEWS
Pesticide and Review Criteria
Possibly Met or Exceeded
Current Status
ALDICARB
Monica Alvarez (703-308-8026)
Acute Toxicity
Ground Water
Contamination
ATRAZINE
Pam Noyes (703-308-8065)
PD 1 published 49 FR 28320 on 7/11/84; comment period closed 9/11/84: NTIS# PB90-259904.
PD 2/3 published 53 FR 24630 on 6/29/88; comment period closed 9/29/88: NTIS# PB90-261611.
Registrant voluntarily removes use on potatoes from label after high residues are found (April 1990).
Registrant agreed to dietary risk reduction measures on 1/30/92 that included voluntary cancellation of the
use on bananas through non-payment of annual maintenance fees and registration amendments to
remaining uses posing dietary risk concern (potatoes, sweet potatoes, oranges, and
grapefruits).
Use on potatoes is allowed back after new application methods demonstrate significantly lower residues
(Sept 1995).
PD 4 to be published concurrent with Reregistration Eligibility Decision (RED) in 2001.
Refer to Triazines
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1. Special Reviews in Process (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Current Status
2,4-D [also 2,4-DB and 2,4-DP]
Robert McNally (703-308-8085)
Carcinogenicity
1,3-DICHLOROPROPENE (TELONE)
Phil Budig (703-308-8029)
Carcinogenicity
DICHLORVOS (DDVP)
Kimberly Lowe (703-308-8059)
Carcinogenicity
Cholinesterase
Inhibition
Chemical is in pre-Special Review status.
Proposed decision not to initiate Special Review published 53 FR 9590 published on 3/23/88.
Industry Task Force on 2,4-D Research Data agreed to risk reduction measures in September, 1992 that
included an exposure reduction plan effected through modifications to technical and
manufacturing use labels and implementation of a user education program.
New rodent carcinoginicity data submitted December '95. Peer review concluded July '96 classified 2,4-D
as a category D carcinogen, that is, unclassifiable as to Carcinogenicity.
Final decision forth coming and will be based on the classification of 2,4-D as a category D carcinogen.
PD 1 published 51 FR 36161 on 10/8/86; comment period closed 12/8/86: NTIS# PB92-114206.
Registrant agreed to implement risk reduction measures at meetings held in September, 1992 and
December, 1995. The registrant will also maintain its education/product stewardship program.
PD 2 published 65 FR 1869 on 1/12/00 proposing to close out Special Review; comment period closes
3/12/00.
RED published December 1998.
PD 4 to be published Summer 2000.
Decision Document published 47 FR 45075 on 10/13/82: NTIS# PB87-181335.
PD 1 published 53 FR 5542 on 2/24/88: NTIS# PB92-114297.
PD 2/3 published 60 FR 50337 on 9/28/95.
PD 4 to be issued concurrent with the RED in 2000 or 2001.
Page 21
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Page 22
1. Special Reviews in Process (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Current Status
ETHYLENE OXIDE
Kimberly Lowe (703-308-8059)
Carcinogenicity PD 1 published 43 FR 3801 on 1/27/78; comment period closed 5/15/78: NTIS# PB80-213903.
Mutagenicity Petition to revoke Section 409 on spice uses received 12/16/87 (52 FR 47753). Position denied (55 FR
Reproductive Effects 35347), but revocation proposal later published 7/1/94 (59 FR 33941) in response to court ruling in Les v.
Reilly. The Food Quality Protection Act of 1996 overturned the 1994 proposal. Residues of EtO on ground
spices are now under FDA's jurisdiction while EPA still regulates those on raw and whole spices.
In 1996, EtO registrants requested label changes to further reduce exposures. All labels carry the new
restrictions effective July 31, 1997.
The Special Review determinations on worker risk will be concurrent with publication of the Reregistration
Eligibility Decision (RED) in FY 2001.
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1. Special Reviews in Process (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Current Status
OXYDEM ETON-M ETHYL
Robert McNally (703-308-8085)
Reproductive effects
PROPAZINE
Pam Noyes (703-308-8065)
PD 1 published 32 FR 37248 on 10/5/87; comment period closed 1/5/88: NTIS# PB91-206581.
Peer Review Committee (PRC) for Developmental and Reproductive Toxicity met on May 7, 1992 to discuss
and evaluate the weight-of-the-evidence of oxydemeton-methyl with reference to its potential for reproductive
and developmental toxicity. The committee concluded that oxydemeton-methyl causes reproductive effects
in rats.
Proposed Notice of Voluntary Cancellation of remaining products published 59 FR 11601 on 3/11/94.
During the comment period, the registration was supported by another registrant. Therefore, final notice
was not issued and the chemical remains in Special Review.
Settlement agreement of September 30, 1994, established a strict timeframe for submission of outstanding
data and temporarily deleted corn, field; popcorn; sorghum; safflower; citrus; onions; pears; turnips; and
snapbeans from the ODM labels. These uses may only be reinstated if EPA's dietary and worker risk
assessments, at the time of the ODM RED document, indicate that there are no risk concerns associated
with these uses.
The ODM Special Review status will be addressed concurrent with the publication of the interim RED in
2000.
Refer to Triazines.
Page 23
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Page 24
1. Special Reviews in Process (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Current Status
SIMAZINE
Pam Noyes (703-308-8065)
TPTH (Triphenyltin Hydroxide)
Phil Budig (703-308-8029)
Developmental
Toxicity
Carcinogenicity
Refer to Triazines.
PD 1 published 50 FR 1107 on 1/9/85; comment period closed 2/22/85: NTIS# PB85-175487.
Data call-in for additional data issued 5/88, 9/90 and 7/93.
Registrants have implemented risk mitigation measures including use deletions, requirements for
mechanical transfer systems for liquid formulations and water soluble bags for wettable powder
formulations, along with additional protective personal equipment and engineering controls as part of special
review and reregistration eligibility decision agreements.
RED published November 1999.
PD 2 to be issued in spring 2000 proposing to close out the Special Review.
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1. Special Reviews in Process (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Current Status
TRIAZINES
Pam Noyes (703-308-8065)
Carcinogenicity
(dietary and occupational)
Ground and Surface Water
Contamination
TRIBUTYLTINS (antifoulant use)
Jill Bloom (703-308-8019)
Mark Hartman (703-308-0734)
Acute and Chronic
Toxicity to Non-
Target Organisms
Grassley-Allen notifications issued for atrazine on 8/17/88, 8/24/89, and 2/8/94.
Notifications issued for simazine and cyanazine on 2/8/94, and for propazine on 8/18/95.
PD 1 published in 59 FR 60412 on 11/23/94; comment period closed 3/23/95. Combined Special
Review initiated for atrazine, simazine and cyanazine due to chemical, toxicological and fate similarities.
Ecological risks are a concern, but not included as a Special Review trigger.
PD 2 for cyanazine published in 61 FR 8186 on 3/1/96 proposing to terminate Special Review of cyanazine
only. Notice of Final Determination to Terminate the Special Review of Cyanazine published in 61 FR 39024 on
7/25/96.
Cyanazine registrations are cancelled, effective 12/31/99. Existing stocks provisions allow use through
12/31/02.
Revised atrazine risk assessment is scheduled for completion in Summer 2000.
SAP on draft atrazine carcinogenicity hazard assessment and characterization, originally set for January 2000,
is being rescheduled due to inclement weather.
Simazine risk assessment and Special Review decision on all the triazines will be completed after the atrazine
work.
PD 1 published 51 FR 778 on 1/8/86; comment period closed 2/24/86: NTIS# PB87-186763.
PD 2/3 published 52 FR 37510 on 10/7/87: NTIS# PB88-161203.
PD 4 published 53 FR 39022 on 10/4/88: NTIS# PB90-261629. Partial conclusion of Special Review; requires
compliance with release rates and prohibitions, modified labeling, and restricted use classification.
Final determination regarding the release of organotin is pending the results of long-term environmental
monitoring study.
EPA concluded in Report to Congress 6/97 that concentrations of TBT in the aquatic environment have dropped
but are still too high. EPA recommended further restrictions.
EPA cooperating in international effort for global phase-out.
Page 25
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2. Special Reviews Completed
Page 26
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
ALACHLOR
Carcinogenicity
AMITRAZ
Carcinogenicity
AMITROLE
Carcinogenicity
PD 1 published 50 FR 1115 on 1/9/85; comment period closed 4/9/85: NTIS# PB85-175503.
PD 2/3 published 51 FR 36166 on 10/8/86; comment period closed 12/8/86: NTIS# PB92-111889.
PD 4 on dietary and applicator risks published 52 FR 49480 on 12/31/87 required restricted use, label warning,
closed systems for large-scale mixer/loaders. NTIS# PB92-114248.
Groundwater concerns will be handled through a regulatory proposal, the State Management Plan (SMP) rule,
under FIFRA section 3.
RED published December 1998.
PD 1 published 42 FR 18299 on 4/6/77; comment period closed 7/18/77: NTIS# PB80-212046.
PD 2/3 published 44 FR 2678 on 1/12/79; comment period closed 2/12/79: NTIS# PB80-211436.
PD 4 published 44 FR 32736 on 6/7/79, 44 FR 59938 on 10/7/79 (correction): NTIS# PB80-211428.
Conditional registration approved for pears but not for apples.
Tolerance for pears approved 12/6/79.
RED published November 1996.
PD 1 published 49 FR 20546 on 6/15/84; comment period closed 7/11/84: NTIS# PB87-187175.
Preliminary determination to terminate the Special Review published 57 FR 46488 on 10/8/92 based on Agency
decision that benefits of use outweigh risks. Final determination published 58 FR 5858 on 1/22/93.
RED published August 1996.
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2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
BENOMYL
Reduction in
Non-target
Organisms
Mutagenicity
Developmental
Toxicity
Reproductive
Effects
Hazard to Wildlife
CADMIUM
Carcinogenicity
Mutagenicity
Developmental
Toxicity
Acute and chronic
kidney toxicity
CAPTAFOL
Carcinogenicity
Acute and Chronic
Wildlife Effects
PD 1 published 42 FR 61788 on 12/6/77; comment period closed 1/23/78: NTIS# PB80-216856.
PD 2/3 published 44 FR 51166 on 8/30/79; comment period closed 9/28/79: NTIS# PB87-119087.
PD 4 published 47 FR 46747 on 10/20/82: NTIS# PB83-148189. Requires use of either cloth or
commercially available disposable dust masks by mixer/loaders of benomyl intended for aerial
application and that registrants of benomyl products conduct field monitoring studies to identify
residues that may enter aquatic sites after use on rice.
Registrant completed field monitoring study and submitted to Agency 11/84. Study not accepted.
New study required by Registration Standard issued 6/87.
PD 1 published 42 FR 56574 on 10/26/77; comment period closed 2/10/78: NTIS# PB87-181376.
PD 2/3 published 51 FR 36524 on 10/10/86; comment period closed 11/24/86: NTIS# PB90-261603.
PD 4 published 52 FR 31076 on 8/19/87: NTIS# PB87-228490. Golf course fairway and home
lawn uses cancelled. Golf course green and tee area uses modified.
6(f) notice published 55 FR 31227 on 8/1/90. Last remaining cadmium chloride registration for use
on golf course tees and greens was voluntarily cancelled.
Proposed decision to terminate the Special Review published 55 FR 49697 on 11/30/90. Final decision
published 56 FR 14522 on 4/10/91.
PD 1 published 49 FR 1103 on 12/9/84; comment period closed 1/31/85: NTIS# PB85-175495.
Press release published on 1/3/85.
All registrations voluntarily cancelled as of 5/15/87.
Proposed decision to terminate Special Review published 52 FR 27576 on 7/22/87.
Final decision published 53 FR 33535 on 8/31/88.
Page 27
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Page 28
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
CAPTAN
Carcinogenicity
CARBOFURAN (granular)
Wildlife Effects
PD 1 published 45 FR 54938 on 8/18/80; comment period closed 12/1/80: NTIS# PB81-109449.
PD 2/3 published 50 FR 25885 on 6/21/85; comment period closed 8/5/85: NTIS# PB87-118014.
PD 4 published 54 FR 8116 on 2/24/89: NTIS# PB90-261579. Certain food use registrations cancelled.
RED published September 1999.
PD 1 on granular formulations published 50 FR 41938 on 10/16/85; comment period closed 12/2/85: NTIS#
PB87-186771.
PD 2/3 published 54 FR 3744 on 1/25/89; comment period closed 3/27/89: NTIS# PB90-261587.
6(f) notice published 55 FR 42266 on 10/18/90. Granular formulations of eight uses voluntarily cancelled.
Settlement agreement to phase out most uses was reached on 5/14/91.
6(f) notice implementing label changes for settlement agreement published 56 FR 33286 on 7/19/91.
PD 4 concluding Special Review published 56 FR 64621 on 12/11/91.
Final notice extending limited use on rice until August 1996, and not extending use on corn and sorghum,
published 60 FR 11090 on 3/1/95.
FIFRA Section 24(c) Special Local Needs registrations were granted in 1996, allowing use of no more than
250,000 Ibs. active ingredient per year on rice in several states during 1997 and 1998.
An acute dietary risk concern under FQPA is being resolved through negotiated risk mitigation with registrant.
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2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
CARBON TETRACHLORIDE
Carcinogenicity
Toxic Effect
on Liver
and Kidneys
PD 1 published 45 FR 68534 on 10/15/80; comment period closed 11/24/80: NTIS # PB81-121782.
Voluntary cancellation of many products published 50 FR 42997 on 10/23/85.
Cancellation of remaining products published 54 FR 41004 on 11/12/86.
Proposed exemption revocation published 52 FR 38200 on 10/14/87.
Expiration date of 7/31/90 for the tolerance exemption on grains published 54 FR 6126 on 2/8/89.
CHLOROBENZILATE
Carcinogenicity
Testicular Effects
PD 1 published 41 FR 21517 on 5/26/76; comment period closed 7/28/76: NTIS# PB92-114313.
PD 2/3 published 43 FR 29824 on 7/11/78; comment period closed 8/10/78: NTIS# PB80-213887.
PD 4 published 44 FR 9547 on 2/13/79: NTIS# PB80-213929. All uses except citrus cancelled.
CHLOROFORM
Carcinogenicity
PD 1 published 41 FR 14588 on 4/6/76; comment period closed 7/23/76. (NTIS# not available).
The Agency determined that applicator exposure had been reduced to a minimum as a result of label
amendments. Also, registrants were required to submit data to establish tolerances of permissible residues
on raw agricultural commodities.
COAL TAR AND CREOSOTE (non-wood use)
Carcinogenicity
Mutagenicity
PD 1 published 43 FR 48154 on 10/18/78; comment period closed 12/4/78: NTIS# PB80-213879.
PD 2/3 published 49 FR 33328 on 8/22/84; comment period closed 10/20/84: NTIS# PB87-178851.
PD4 published 50 FR41943 on 10/16/85: NTIS# PB87-180485. Cancellation of all uses except gypsy moth
egg masses; deferral on coal tar neutral oil (CTNO) use pending receipt of additional data.
Cancellation of all remaining uses published 5/15/86.
Page 29
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Page 30
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
CREOSOTE (wood use)
Carcinogenicity
Mutagenicity
CYAIMAZINE
Pam Noyes (703-308-8065)
Developmental
Toxicity
Carcinogenicity
(dietary and non-dietary)
Ground and Surface Water
Contamination
PD 1 published 43 FR 48154 on 10/18/78; comment period closed 2/12/79: NTIS# PB80-213879.
PD 2/3 published 46 FR 13020 on 2/19/81; comment period closed 5/20/81: NTIS# PB82-229956.
At 4/14/83 public meeting, proposed conclusion presented; comment period closed 5/13/83.
PD 4 published 49 FR 28666 on 7/13/84: NTIS# PB84-241538. Requires label changes including a restricted
use classification.
Subsequently, two FR notices published: 49 FR 43772 on 10/31/84, and 50 FR 4269 on 1/30/85.
PD 1 published 50 FR 6560 on 4/10/85; Toxicity comment period closed 5/27/85: NTIS#
PB87-117982.
PD 2/3 published 52 FR 589 on 1/17/87; comment period closed 3/9/87: NTIS# PB87-181400.
PD 4 published 53 FR 795 on 1/13/88. Required label warning and protective clothing: NTIS#
PB90-261595.
Hearing requested 2/88. Settlement reached 5/88 revising hazard warning statement and extending existing
stocks provision.
Grassley-Allen notification issued on 2/8/94 for Carcinogenicity, ground/surface water contamination,and
ecological effects.
PD 1 published in 59 FR 60412 on 11/23/94. Registrants voluntarily amended terms and conditions
of cyanazine registrations on 8/25/95 that included: annual reductions in maximum application rates,
requirement for closed cab application equipment, and voluntary cancellation of all products, effective 12/31/99.
Use of existing stocks permitted through 12/31/02.
PD 2 published in 61 FR 8186 on 3/1/96 proposing to terminate the Special Review of cyanazine based on the
amended terms and conditions of registration. Final determination terminating the cyanazine Special Review
published in 61 FR 30924 on 7/25/96.
Cancellation order published in 65 FR 771 on 1/6/00 confirming cancellation of all cyanazine registrations
effective 12/31/99.
See also Triazines.
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2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
DAMINOZIDE
Carcinogenicity
DBCP (Dibromochloropropane)
Carcinogenicity
Reproductive
Effects
Mutagenicity
Ground Water
PD 1 published 49 FR 29136 on 7/18/84; comment period closed 8/31/84: NTIS# PB92-114222.
Draft PD 2/3/4 issued 9/12/85.
Data Call-in Notice issued 2/10/86.
PD 2/3 proposing to cancel food uses only published 54 FR 22558 on 5/24/89: NTIS# PB92-114214.
Registrant voluntarily halted sale of daminozide food use products on 6/2/89.
Proposed tolerance revocation published 54 FR 37277 on 9/7/89.
PD 4 announcing close of Special Review for food uses, and impending risk assessment for workers published
54 FR 47492 on 11/14/89: NTIS# PB92-114198.
Final tolerance revocation published 55 FR 10218 on 3/19/90.
PD 4 announcing close of Special Review for non-food uses published 57 FR 46436 on 10/8/92. Determination
made to retain non-food uses without requiring label modifications. Agency also revised dietary risks and
concluded that the risks posed in 1989 were unreasonable and the Agency's decision at that time concerning
dietary risks will not be changed.
PD 1 published 42 FR 48026 on 9/22/77; comment period closed 11/7/77: NTIS# PB87-181368.
Suspension order and notice of intent to cancel all food uses published Contamination 42 FR 57543
on 11/3/77.
Amended notice of intent to cancel and PD 2/3/4 published 43 FR 40911 on 9/13/78: NTIS# PB80-
213853.
Notice of intent to suspend all products published 44 FR 43335 on 7/24/79.
Suspension order for all uses except pineapples published 44 FR 65161 on 10/29/79.
Notice of intent to cancel all uses published 44 FR 65170 on 11/9/79.
Withdrawal of the notice of intent to cancel use on pineapples published 46 FR 19592 on 3/31/81.
Proposed intent to cancel use on pineapples published 49 FR 1556 on 1/12/84; comment period closed
3/12/84.
Press release published on 1/3/85.
Final PD 4 published 50 FR 1122 on 1/9/85. Cancellation of remaining registrations. (NTIS# not available).
Page 31
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Page 32
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
DIALLATE
Carcinogenicity PD 1 published 42 FR 27669 on 5/31/77; comment period closed 9/9/77: NTIS# PB80-212863.
Mutagenicity PD 2/3 published 45 FR 38437 on 6/9/80; comment period closed 7/9/80: NTIS# PB80-216849.
PD 4 published 47 FR 27109 on 6/23/82: NTIS#PB87-118006. Restricted use to certified applicators wearing
protective clothing.
DIAZINON
Avian Hazard PD 1/2/3 published 51 FR 1842 on 1/15/86; comment period closed 3/3/86; extended to 3/28/86 (51 FR 8813):
NTIS#PB87-101853.
PD 4 published 51 FR 35034 on 10/1/86: NTIS#PB90-261645. Cancellation of golf course and sod farm uses.
Amendment to PD 4 published 52 FR 5656 on 2/25/87.
Registrant-requested hearing confirmed PD 4 decision in 4/88.
Registrants appealed; PD 4 remanded to the Administrator on 6/2/89.
6/19/90 press release announced the Administrator's Remand Decision upholding the 1988 final decision to
cancel all use on golf courses and sod farms.
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2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
DICOFOL
Ecological Effects
DIMETHOATE
Carcinogenicity
Mutagenicity
Fetotoxicity
Reproductive
Effects
PD 1 published 49 FR 10569 on 3/21/84; comment period closed 5/5/84: NTIS# PB84-160084.
PD 2/3 published 49 FR 39820 on 10/10/84; comment period closed 11/26/84: NTIS# PB85-134153.
Amendment to PD 2/3 published 50 FR 33008 on 8/15/85.
PD 4 published 51 FR 19508 on 5/29/86: NTIS# PB90-260431. Requires a reduction in the level of DDTr
contamination, and modified labeling.
RED published November 1998.
PD 1 published 42 FR 45806 on 9/12/77; comment period closed 1/6/78: NTIS# PB87-181343.
PD 2/3 published 44 FR 66558 on 11/19/79; Effects comment period closed 12/19/79: NTIS#
PB80-213846.
PD 4 published 46 FR 5364 on 1/19/81: NTIS# PB81-172413. Denies applications for dust
formulations, and requires modified labeling.
DINOCAP
Developmental
Toxicity
PD 1 published 50 FR 1119 on 1/9/85; comment period closed 2/22/85. (NTIS# not available).
PD 2/3 published 51 FR 39577 on 10/29/86; comment period closed 12/29/86: NTIS# PB87-178844.
PD 4 published 54 FR 5908 on 2/6/89. Requires health hazard label statement and additional protective
clothing.
Page 33
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Page 34
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
DINOSEB
Developmental Emergency Suspension Order/Notice of Intent to Cancel published 51 FR 36634 on 10/14/86:
Toxicity NTIS#PB87-225041.
Reproductive As a result of a Subpart D hearing, the Agency modified the 10/7/86 Suspension Order to permit
Effects use of dinoseb on dry peas, lentils, and chick peas in Idaho and Washington during the 1987 and
Acute Effects 1988 growing season. A subsequent court order permitted use on the same crops in certain counties in
Oregon. A second District Court ruling permitted dinoseb use on caneberries, curcurbits, green peas, and snap
beans in the States of Idaho, Oregon, and Washington. A final cancellation order was issued on 6/9/88.
Besides cancelling all remaining uses, it permitted limited use on certain crops in the Pacific Northwest during
the 1988 and 1989 growing seasons.
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2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
EBDCs (Ethylene bisdithiocarbamates: Maneb, Mancozeb, Metiram, Nabam, Zineb, Amobam)
Robert McNally (703-308-8085)
Carcinogenicity
PD 1 published 41 FR 40618 on 8/10/77; comment period closed: NTIS# PB87-228482.
Decision Document and Final Determination published 47 FR 47669 on 10/27/82: NTIS# PB87-181350.
Requires modified labeling and additional toxicological data.
Carcinogenicity
Developmental
Toxicity
PD 1 published 52 FR 27172 on Thyroid Effects on 7/17/87; comment period closed 9/30/87:
NTIS#PB87-117990.
The sole Nabam registrant requested voluntary cancellation of all food uses in 3/89.
Registrants announced on 9/6/89 that they will drop all but 13 registered food uses.
PD 2/3 published 54 FR 52158 on 12/20/89 proposing to cancel all uses for zineb and 45 food crop uses of
mancozeb, maneb, and metiram. 10 crop uses proposed to be retained. Comment period closed 3/20/90:
NTIS#PB90-143025.
Notice published 55 FR 15018 on 4/20/90 reopening comment period on PD 2/3 for 48 of 55 food uses
(mancozeb, maneb, and metiram). Comment period for narrative information closed 6/30/90 and for new data
on 9/30/90.
Notice published 55 FR 20416 on 5/16/90 proposing to reduce and/or revoke tolerances and food/feed additive
regulations.
Notice published 55 FR 40206 on 10/2/90 reopening comment period on 5/16/90 proposal; new comment period
closed 1/2/91.
PD 4 published 57 FR 7484 on 3/2/92. The PD 4 announced the Agency's intent to cancel 11 uses. After a
hearing settlement, 3 of these 11 uses were retained. EBDC products registered for 45 other food crops
continue upon required modifications being made to avoid cancellation. Industrial uses of nabam continue.
Home garden uses of mancozeb on turf and fruit are cancelled. Other homegarden uses remain registered
subject to certain conditions. All registrations of zineb were previously voluntarily cancelled by the registrant.
Page 35
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Page 36
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
ENDRIN
Carcinogenicity PD 1 published 41 FR 31316 on 7/27/76; comment period closed 11/4/76: NTIS# PB81-112690.
Developmental PD 2/3 published 43 FR 51132 on 11/2/78; comment period closed 12/4/78: NTIS#
Toxicity PB87-119921.
Reduction in PD 4 published (including cancellations) 44 FR 43631 on 7/25/79: NTIS# PB81-109480.
Endangered and PD 4 follow-up notice sent 8/28/80.
Non-Target Cancellations by Velsicol of one technical and two end-use products effective 11/23/84.
Species Velsicol's last end-use product was voluntarily cancelled as of 8/1/85.
All but one remaining uses were voluntarily cancelled effective 9/12/85.
EPN (Ethyl (p-nitrophenyl)thiobenzene phosphonate)
Neurotoxicity PD 1 published 44 FR 54384 on 9/19/79; comment period closed 12/29/79; NTIS# PB80-216815
Hazard to Aquatic Determination to conclude RPAR published in 48 FR 39494 on 8/31/83. Mosquito larvicide use
Organisms cancelled. New label requirements imposed for all other uses to reduce exposure to applicators and non-target
organisms, and reassess tolerances, chronic toxicity and reentry.
Proposed Decision Not To Initiate Special Review published 52 FR 27453 on 7/21/87.
Final Decision Not to Initiate Special Review published 52 FR 48574 on 12/23/87.
All registrations voluntarily cancelled as of 7/24/87.
ETHALFLURALIN
Carcinogenicity PDs 1, 2/3, and 4 published 49 FR 511 on 1/4/84; comment period closed 12/1/85: NTIS# PB92-114263.
Benefits of conditional registration exceeded risks. Submission of additional data required by 12/1/85.
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2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
ETHYLENE DlBROMIDE (EDB)
Carcinogenicity
Mutagenicity
Reproductive
Effects
FLUOROACETAMIDE
Acute Toxicity to
Mammalian and
Avian Species
Reduction in
Endangered
Species and
Non-Target
Acute Toxicity
without Antidote
PD 1 published 42 FR 63134 on 12/14/77; comment period closed 4/3/78: NTIS# PB80-109456.
PD 2/3 published 45 FR 81586 on 12/10/81; comment period closed 3/9/82: NTIS# PB81-157851.
PD 4 published 48 FR 45956 on 10/7/83: NTIS# PB85-238004.
Emergency Suspension published 49 FR 4452 on 2/6/84: NTIS# PB85-235919. Uses to fumigate grain and
grain milling equipment were suspended. Proposed tolerances for EDB in grains published 49 FR 6697 on
2/22/84.
Proposed tolerances for EDB in citrus and papayas published 49 FR 8407 on 3/6/84.
Amendment to Notice of Intent to Cancel registrations of pesticide products containing EDB published 49 FR
14182 on 4/10/84.
Final tolerances for EDB in grains published 49 FR 17144 on 4/23/84.
Final revocation of tolerances and establishment of interim tolerances for EDB in citrus and papaya published
49 FR 22082 on 5/25/84.
Proposed revocation of tolerances for miscellaneous commodities published 49 FR 32085 on 8/10/84.
Interim tolerance for EDB in mangoes was published 9/29/86. Tolerance expired 9/30/87.
Papaya registration voluntarily cancelled as of 3/87.
Use on citrus for export terminated at end of 1988/1989 harvest season.
Only remaining uses are vault fumigation, and quarantine fumigation of nursery stock.
PD 1 published 41 FR 52792 on 12/1/76: NTIS# PB80-216823.
PD 2 published 45 FR 13189 on 2/28/80: NTIS# PB80-216831.
Chemical returned to registration process with the restriction that it be used only in sewers.
Page 37
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Page 38
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
GOAL (Oxyfluorfen)
Carcinogenicity PD 1/2/3 published 46 FR 23490 on 4/27/81; comment period closed 5/11/81: NTIS# PB82-185133.
PD 4 published 47 FR 27118 on 6/23/82: NTIS# PB82-172289.
Decision made to continue use of the herbicide subject to certain restrictions (on PCE) pertaining to formulation
of product.
INORGANIC ARSENICALS (wood use)
Carcinogenicity PD 1 published 43 FR 48267 on 10/18/78; comment period closed 2/12/79: NTIS# PB87-181327.
Mutagenicity PD 2/3 published 46 FR 13020 on 2/19/81; comment period closed 5/20/81: NTIS# PB82-229956.
Developmental At 4/14/83 public meeting proposed conclusion presented; comment period closed 5/15/83.
Toxicity PD 4 published 49 FR 28666 on 7/13/84: NTIS#PB84-241538. Requires label changes, including a restricted
use classification.
Subsequently, two FR notices were published: 49 FR 43772 on 10/31/84, and 50 FR 4269 on 1/30/85.
-------
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
INORGANIC ARSENICALS (non-wood use)
Carcinogenicity
Mutagenicity
Developmental
Toxicity
PD 1 published 43 FR 42867 on 10/18/78; comment period closed 2/12/79: NTIS# PB87-181327.
PD 2/3 published 52 FR 132 on 1/2/87; comment period closed 2/17/87. Following uses were not
included: 1) calcium arsenate use as turf herbicide, 2) lead arsenate use as grapefruit growth
regulator, 3) sodium arsenite use as grape fungicide, and 4) arsenic acid use as dessicant: NTIS# PB92-
114297.
PD 4 excluding above 4 uses published 53 FR 24787 on 6/30/88. a) Registrants of ant bait formulations filed
hearing request on 7/29/88. Use of sodium arsenate as ant bait cancelled on 7/26/89 upon completion of
hearing, b) All registrations cancelled except for arsenic trioxide use as insecticide and mole/gopher control:
NTIS# PB92-114305.
PD 2/3 for remaining four uses published 56 FR 50576 on 10/7/91; however, three of the remaining four uses
had already been voluntarily cancelled: a) lead arsenate - 9/87; b) calcium arsenate - 2/89; c) sodium arsenite
-11/90 (56 FR 28154 on 6/19/91).
Lead/calcium arsenate tolerance revocation proposals published 55 FR 33332 on 8/15/90. Final revocations
published 56 FR 13593 on 4/3/91.
PD 4 published 58 FR 64579 on 12/8/93. Concluded the Special Review for the remaining non-wood uses of
inorganic arsenicals: lead arsenate growth regulator on citrus, calcium arsenate herbicide on turf, sodium
arsenite fungicide on grapes and arsenic acid desiccant on okra for seed and cotton.
Page 39
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2. Special Reviews Completed (continued)
Page 40
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
LINDANE
Carcinogenicity
Developmental
Toxicity
Reproductive
Effects
Other Chronic
Effects
Acute Toxicity
LINURON
Carcinogenicity
MALEIC HYDRAZIDE
Carcinogenicity
Mutagenicity
Reproductive
Effects
PD 1 published 42 FR 9816 on 2/18/77; comment period closed on 6/20/77: NTIS# PB80-213861.
PD 2/3 published 45 FR 45362 on 7/3/80; comment period closed 9/15/80: NTIS# PB87-165080.
PD 4 published 48 FR 48512 on 10/19/83: NTIS#PB87-165098. The decision cancelled the indoor
use of smoke fumigation devices and the use of dog dips to treat pests other than mites. All
other uses will continue with use restrictions and label modifications.
Negotiated settlement on dog dips published 49 FR 26282 on 6/27/84. A settlement on smoke
bombs published 50 FR 5425 on 2/8/85 to end sale of product by 5/31/86 for registrant and by
11/30/86 for retailer.
Due to international concerns about persistent organochlorine pesticides (POPs), an international consortium
of lindane producers has promised to limit its use, starting with their U.S. registration. Most uses of the major
U.S. registrant's lindane product may be voluntarily cancelled. Other registrants also may limit use of their
lindane products in this country.
PD 1 published 49 FR 37843 on 9/26/84; (rebutted) comment period closed 11/10/84: NTIS# PB85-174654.
Preliminary Decision to Conclude Special Review published 53 FR 31262 on 8/17/88.
Final Determination to Conclude published 54 FR 4072 on 1/27/89. No regulatory action warranted.
PD 1 published 42 FR 56920 on 10/28/77; comment period closed 12/14/77: NTIS# PB80-216740.
Decision Document published 47 FR 498 on 1/5/82: NTIS# PB82-240300. This action returned maleic
hydrazide and salts (K-MH, DEA-MH) to the registration process.
All required data have been submitted to the Agency.
Registrants decided not to perform similar tests on DEA-MH. Thus, DEA-MH was suspended 11/81.
-------
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
PCNB (Pentachloronitrobenzene)
Carcinogenicity
PD 1 published 42 FR 61894 on 10/13/77; comment period closed 2/6/78: NTIS# PB80-216799.
Special Review was terminated through negotiated agreement with registrants to reduce levels of the HCB
contaminant and to make label changes to reduce exposure. Published 47 FR 18177 on 4/19/82.
PENTACHLOROPHENOL (non-wood use)
Carcinogenicity
Developmental
Toxicity
PD 1 published 43 FR 48443 on 10/18/78: NTIS# PB87-109464.
PD 2/3 published 49 FR 48367 on 12/12/84; comment period closed 2/14/86: NTIS# PB87-119095.
Special Review on oil well, cooling tower, and pulp and paper uses deferred until exposure data are received.
Data call-in issued 8/4/88.
PD 4 published 52 FR 2282 on 1/21/87: NTIS# PB87-204707. Non-deferred uses cancelled.
Amendment to PD 4 (clarifying uses) published 53 FR 5524 on 2/24/88.
PD 4 published 58 FR 7848 on 2/9/93 announcing termination of the Special Review for non-wood use.
Registrants either voluntarily cancelled registrations or allowed registrations
to be cancelled because of non-payment of required annual registration maintenance fees.
Page 41
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2. Special Reviews Completed (continued)
Page 42
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
PENTACHLOROPHENOL (wood use)
Carcinogenicity
Fetotoxicity
Developmental
Toxicity
PRONAMIDE
Carcinogenicity
PD 1 published 43 FR 48443 on 10/18/78; comment period closed 2/12/79: NTIS# PB81-109464.
PD 2/3 published 46 FR 13020 on 2/19/81; comment period closed 5/20/81: NTIS# PB82-229956.
At 4/14/83 public meeting proposed conclusion presented; comment period closed 5/13/83.
PD 4 published 49 FR 28666 on 7/13/84: NTIS#PB84-241538. Requires label changes including a restricted
use classification.
Subsequently, two FR notices were published: 49 FR 43772 on 10/31/84 and 50 FR 4269 on 1/30/85.
Amendment to PD 4 published 51 FR1334 on 1/10/86.
Amendment to amended PD 4 published 52 FR 140 on 1/2/87.
PD 1 published 42 FR 32302 on 5/20/77; comment period closed 8/29/77: NTIS# PB81-109472.
PD 2/3 published 44 FR 3083 on 1/15/79; comment period closed 2/14/79: NTIS# PB80-213911.
PD 4 published 44 FR61640 on 10/26/79: NTIS# PB81-112716. The following actions were taken: Cancellation
of registration of products allowing hand spray applications, except for use on ornamentals and nursery stock;
cancellation of registrations of products unless the registrant modifies the terms and
conditions to allow certain uses of wettable powder products only by or under direct supervision of certified
applicators; modification of labeling of wettable powder products to include specific general precautions,
directions as to protective clothing to be worn, dilution instructions for wettable powder products, and watering
instructions for granular products used on turf; and Agency revision of the lettuce tolerance from 2 ppm to 1 ppm
from required residue data that was submitted.
SODIUM FLUOROACETATE (Compound 1080)
Reduction in
Non-Target and
Endangered
Species
PD 1 published 41 FR 52792 on 12/1/76; comment period closed
No Antidote 3/15/77: NTIS# PB80-216823.
PD 2/3 signed on 11/11/82; re-signed on 6/29/83; published 48 FR 50935 on 11/4/83: NTIS# PB87-
182226. Issuance of PD delayed to coincide with document addressing predator issues.
SAP reviewed PD 2/3 and issued a final report on 7/3/84, following 6/12/84 SAP meeting.
PD4 published 50 FR 31012 on 7/31/85: NTIS# PB87-116471. Modified labeling and certain bait concentration
reductions required.
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2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
STRYCHNINE/STRYCHNINE SULFATE
Reduction in
Non-target and
Endangered
Species
2,4,5-T/SILVEX
Carcinogenicity
Fetotoxicity
Developmental
Toxicity
PD 1 published 42 FR 2713 on 1/13/77; comment period closed 3/15/77: Endangered NTIS# PB80-
216807.
PD 2/3 published 45 FR 73602 on 11/5/80; comment period closed 9/30/81: NTIS# PB81-123960.
PD 4 published 48 FR 48522 on 10/19/83: NTIS# PB87-182234. Decision cancelled use of strychnine for
control of prairie dogs and several other rodents and small mammals. All other uses will require label
modifications.
Notice published 52 FR 6762 on 3/4/87 withdrawing partial cancellation of strychnine active ingredient
pesticides for prairie dog, ground squirrel, and meadow mouse control if certain modifications of terms and
conditions of registration are made. Terms and conditions include: establishment of a State program for
exclusive distribution and monitoring of strychnine for use on prairie dogs; compliance with Black-Footed Ferret
Survey Guidelines; and use of certain label statements.
2,4,5-T PD 1 published 43 FR 17116 on 4/21/78; comment period closed 6/5/78: NTIS#
PB80-212665.
2,4,5-T: PD 2/3 published 44 FR 41536 on 7/17/79; comment period closed 8/16/79: NTIS# PB87-
117685.
Silvex: PD 1/2/3 published 44 FR 41536 on 7/17/79; comment period closed 8/16/79: NTIS# PB80-213895.
Emergency Suspension Order and Notice of Intent to Cancel published 44 FR 15874 on 3/15/79. 2,4,5-T:
NTIS# PB80-225923; Silvex: PB80-226376.
2,4,5-T/Silvex-PD 4 published 44 FR 72316 on 12/13/79: NTIS# PB87-181384.
Cancellation hearings began 3/14/80.
On 10/11/84, the Administrative Law Judge gave Union Carbide 30 days to determine if they wanted to defend
2,4,5-T/Silvex uses. Union Carbide and remaining companies withdrew from the hearing and all registrations
were cancelled on 1/2/85.
Page 43
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2. Special Reviews Completed (continued)
Page 44
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
THIOPHANATE-M ETHYL
Mutagenicity
Carcinogenicity
Reduction in
Non-target
Species
(Rebutted)
TOXAPHENE
Carcinogenicity
Population
Reduction in
Non-Target
Animal Species
Acute Toxicity to
Aquatic Organisms
Chronic Effects to
Wildlife
2,4,5-TRICHLOROPHENOL (TCP)
Carcinogenicity
Fetotoxicity
PD 1 published 42 FR 61970 on 12/7/77; comment period closed 3/27/78: NTIS# PB80-216856.
PD 2/3 published 44 FR 58798 on 10/11/79; comment period closed 11/12/79: NTIS# PB87-119087.
PD 4 published 47 FR 46747 on 10/20/82: NTIS# PB83-148189. No regulatory action warranted.
PD 1 published 42 FR 26860 on 5/27/77; comment period closed 6/13/77: 5/27/77; comment period
closed NTIS# PB80-216732.
PD 2/3/4 published 47 FR 53784 on 11/29/82: NTIS# PB83-144204. Cancellation of registrations for
most uses and continued registration of certain uses under specific terms and conditions. The
continued uses are: corn, cotton, and small grain for specific insect infestation (emergency use only);
pineapples and bananas for specific insects in Puerto Rico and the Virgin Islands only; and scabies
treatments of cattle and sheep.
PD 1 published 43 FR 34026 on 8/2/78; comment period closed 11/17/78: NTIS# PB81-103111.
Action temporarily deferred pending 2,3,5-T/Silvex proceedings.
3(c)(2)(B) letter issued on May 7, 1985 requesting updated Confidential Statement of Formula, analysis for
dioxin contamination, and teratology data. Most products were voluntarily cancelled in response.
PD 2/3/4 published 52 FR 15549 on 4/29/87: NTIS# PB87-203113. Cancellation of all uses.
-------
2. Special Reviews Completed (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
TRIFLURALIN
Carcinogenicity PD 1/2/3 published 44 FR 50911 on 8/30/79; comment period closed 11/13/79: NTIS# PB80-213937.
Mutagenicity PD 4 published 47 FR 33777 on 8/4/82: NTIS# PB82-263252. Registration allowed to continue if total
N-nitrosamine contamination is kept below 0.5 ppm fortechnical products, and below a figure based on trifluralin
content for formulated products.
RED published April 1996.
Page 45
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3. Final Determinations on Pre-Special Reviews/Deferred to Reregistration
Page 46
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
CACODYLIC ACID AND SALTS
Carcinogenicity
Mutagenicity
Developmental
Toxicity
CARBARYL
Carcinogenicity
Mutagenicity
Developmental
Toxicity
Insufficient evidence to issue a Special Review.
Decision Document published 47 FR 20376 on 5/12/82: NTIS# PB91-234278. Returned to the
registration process with the stipulation that, pursuant to section 3(c)(2)(B), data on the rate
of dermal absorption be submitted, knapsack/hand sprayer applicators treating ditch banks and rights-of-way
will wear respirators or masks, and labels recommend masks for home users employing knapsacks or hand
sprayers. The data was submitted and the Agency did not impose labeling changes.
Decision Document published 45 FR 81869 on 12/12/80: NTIS# PB87-181301.
The Agency has returned this compound to the registration process with the stipulation that the
following measures be considered: (1) a section 3(c)(2)(B) action that registrants remedy data gaps
identified in pre-special review and (2) appropriate label changes be made to minimize exposure to carbaryl.
CHLORINATED ISOCYANURATES
Kidney Effects
The Agency concluded in the Registration Standard (5/20/88) that chlorinated isocyanurates do not exceed the
risk criteria for adverse effects in 40 CFR 154.7.
DIFLUBENZURON (Dimilin)
Hazard to Wildlife
RPAR action completed and Decision Document issued on 3/26/79: NTIS# PB87-187191. Registrant
consented to restricted use.
Agency concluded that existing evidence does not support issuance of a Special Review.
-------
3. Final Determinations on Pre-Special Reviews/Deferred to Reregistration (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
LINDANE
Kidney effects Grassley-Allen preliminary notification issued 9/18/85.
Docket index of material is available for public use.
Proposed Notice Not To Initiate Special Review published 59 FR 12916 on 3/18/94. EPA determined that
kidney effects observed are specific to the male rat and are not revelant to human health risk.
Final decision published 60 FR 38329 on 7/26/95. EPA reaffirmed the findings of its proposed decision; but
added that it would review the possible endocrine disruption effects of organochlorines as alleged in the
literature.
METHANEARSONATES
(includes Amine Methanearsonate, Calcium Acid Methanearsonate (CAMA), Monosodium Methanearsonate (MSMA), Disodium
Methanearsonate (DMSA))
Carcinogenicity
Mutagenicity
NALED
Mutagenicity
Fetotoxicity
Reproductive Effects
OBPA (10,10'-Oxybisphenoxarsine)
Carcinogenicity
Mutagenicity
Developmental
Toxicity
On 6/28/83, the pre-Special Review for methanearsonate chemicals was completed and a decision
memorandum approved returning these chemicals to the registration process. The existing evidence was
inadequate to initiate a Special Review.
3(c)(2)(B) letter sent 9/26/83 requiring a chronic feeding, oncogenicity, teratology, and applicator exposure
studies in order to determine if there are any risk concerns.
Chemical returned to the registration process on 6/30/83, based on a review of all available data which
indicated that no Effects valid tests or definitive evidence existed which met or exceeded the Special
Review risk criteria.
Decision Document issued 4/9/79. (NTIS# not available). Returned to the registration process due
to lack of Toxicity evidence of oncogenicity in the suspected arsenical compound.
Page 47
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Page 48
3. Final Determinations on Pre-Special Reviews/Deferred to Reregistration (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
PARAQUAT DICHLORIDE
Emergency
Treatment
Chronic Effects
PARATHION (ETHYL)
Acute Human Poisoning
PHORATE
Wildlife Adverse Effects
PIPERONYL BUTOXIDE
Carcinogenicity
PROPOXUR
Carcinogenicity
Decision Document published 47 FR 45075 on 10/23/82: NTIS# PB87-181392.
Outlined data gaps and voluntary cancellation of certain non-crop use sites.
RED published August 1997.
Grassley-Allen letter on acute human toxicity and avian trigger sent on 5/16/86.
Negotiated settlement in September 1991 resulted in voluntary cancellation of all but nine field crop uses.
Cancellation order published in 56 FR 65061 on 12/13/91.
OPP reviewing ecological risk associated with the remaining nine uses as part of reregistration.
Chemical was in pre-Special Review.
Grassley-Allen preliminary notification issued 12/12/88 for avian effects and 8/2/90 for aquatic effects.
Docket index of material is available for public use.
Chemical is currently being evaluated for reregistration; interim RED anticipated in 2000.
Decision Document published 47 FR 20376 on 5/12/82: NTIS# PB83-137901. Chemical returned to the
registration process and a section 3(c)(2)(B) notice requesting additional data issued on 9/30/82.
Studies received 8/87 and reviewed 4/8/88 by Toxicology Branch.
Grassley-Allen preliminary notification issued 3/88.
Docket index of material is available for public use.
Proposed Notice not to Initiate Special Review published 60 FR 3210 on 1/15/95.
Final Notice not to Initiate Special Review published 61 FR 7508 on 2/28/96.
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3. Final Determinations on Pre-Special Reviews/Deferred to Reregistration (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
ROTENONE
Carcinogenicity Decision Document published 46 FR 36745 on 7/15/81 (NTIS# not available).
Mutagenicity Chemical returned to the registration process based on a finding of no unreasonable adverse effects.
Developmental
Toxicity
Reproductive
Effects
Chronic Effects
Significant Wildlife
Population Reductions
Acute Toxicity to
Aquatic Wildlife
TERBUFOS
Ecological Adverse Effects Chemical was in pre-Special Review.
Grassley-Allen preliminary notification issued 12/12/88 for avian effects and 8/2/90 for aquatic effects.
Docket index of material is available for public use.
Chemical is currently being evaluated for reregistration; interim RED anticipated in 2000.
TERBUTRYN
Carcinogenicity Decision Document published 47 FR 20376 on 5/12/82: NTIS# PB91-206573.
Mutagenicity Chemical returned to the registration process. Registrants agreed to change label to reduce applicator
Reproductive Effects risk to acceptable levels.
Page 49
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3. Final Determinations on Pre-Special Reviews/Deferred to Reregistration (continued)
Page 50
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
TRIALLATE
Carcinogenicity
Mutagenicity
Decision Document published 45 FR 92349 on 12/15/80: NTIS# PB90-259920. The Agency
determined that, in light of the low level of exposure, the chemical should be returned to the registration process
stipulating that a section 3(c)(2)(B) action be initiated to obtain necessary toxicity data to evaluate its hazards.
3(c)(2)(B) was issued on 6/15/84 to include the data needs.
S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE
Neurotoxicity
TRIBUTYL PHOSPHOROTRITHIOITE
Neurotoxicity
TRICHLORFON
Carcinogenicity
Mutagenicity
Developmental
Toxicity
Reproductive Effects
Decision Document published 47 FR 20376 on 5/12/82: NTIS# PB87-186789.
Returned to the registration process based on a finding of no unreasonable adverse effects. Registrants agreed
to protective clothing requirement.
Decision Document published 47 FR 20376 on 5/12/82: NTIS# PB87-186797.
Returned to the registration process based on a finding of no unreasonable adverse effects. Registrants agreed
to protective clothing requirement.
Chemical returned to the registration process on 6/30/83 based on a review of all available data which
indicated that no valid tests or definitive evidence existed which met or exceeded the Special
Review risk criteria.
-------
4. Final Actions/Voluntary Cancellations
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
ACRYLONITRILE
Carcinogenicity
Developmental
Toxicity
Neurotoxicity
ARSENIC TRIOXIDE
Carcinogenicity
Mutagenicity
Developmental
Toxicity
BENZENE
Carcinogenicity
Mutagenicity
Blood Disorders
BHC
Carcinogenicity
CAPTAFOL
Carcinogenicity
43 FR 26310 (6/19/78). Three products only.
42 FR 45944 (9/13/77). Some uses were cancelled.
All products voluntarily cancelled on 7/31/85.
43 FR 31432 (7/21/78). NTIS# PB80-216781.
All products voluntarily cancelled 5/15/87.
Page 51
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4. Final Actions/Voluntary Cancellations (continued)
Page 52
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
CARBON TETRACHLORIDE
Carcinogenicity
Toxic Effects on
Liver and Kidneys
CHLORANIL
Carcinogenicity
CHLORDANE
Carcinogenicity
50 FR 42997 (10/23/85). Many products cancelled.
42 FR 3702 (1/19/77).
53 FR 11798 4/8/88 announced cancellation of many termiticide products and termination of sale, distribution,
and use (except by homeowners) as of 4/15/88.
Primary registrant agreed 8/11/87 to cancel some registrations and not to market any remaining registrations
in the U.S. unless air-monitoring studies showed no detectable, air-borne residues. Conditions of the study
requirements were not met; thus, the remaining two registrations were terminated per agreement on 8/11/94.
CHLORDIMEFORM
Carcinogenicity
COPPER ACETOARSENITE
Carcinogenicity
Mutagenicity
Developmental
Toxicity
Proposed decision not to initiate Special Review due to voluntary cancellation of all products published 53 FR
36422 on 9/19/88.
Final decision published 54 FR 6242 on 2/8/89 allowed use of existing stocks by end users until 10/1/89.
42 FR 18422 (4/7/77).
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4. Final Actions/Voluntary Cancellations (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
COPPER ARSEIMATE
Carcinogenicity 42 FR 18422 (4/7/77).
(Basic)
CYHEXATIN
Developmental Toxicity All products voluntarily cancelled 9/25/87.
ENDRIN
Reduction in Cancellation of all uses except one effective 9/12/85.
Endangered
Species and Non-
Target Species
EPN (Ethyl(p-nitrophenyl)thiobenzene phosphonate)
Neurotoxicity All products voluntarily cancelled on 7/24/87.
Hazard to Aquatic
Organisms
ERBON
Carcinogenicity 45 FR 58770 (10/4/80).
Developmental Toxicity
Fetotoxicity
Page 53
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4. Final Actions/Voluntary Cancellations (continued)
Page 54
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
HEPTACHLOR
Carcinogenicity
MERCURY
Acute to
Subchronic Human
Inhalation
Exposure Toxicity
METAM-SODIUM
Acute Dermal Toxicity
Inhalation Hazard
Developmental Toxicity
METHAZOLE
Ocular effects
53 FR11798 (4/8/88) announced cancellation of many termiticide products and termination of sale, distribution,
and use (except homeowner products) as of 4/15/88. All remaining products are withdrawn or suspended under
section 3(c)(2)(B).
Major registrant Velsicol agreed on 8/11/87 to cancel some termiticide products and withdraw all others unless
indoor air monitoring studies showed no detectable levels. Conditions of the study requirements were not met;
thus, the remaining termiticide registrations were terminated per agreement on 8/11/94.
The final remaining registered product for use in underground junction boxes to control fire ants was voluntarily
cancelled on 7/29/99, allowing use of existing stocks through 1/15/00.
6(f) notice published 55 FR 26754 on 6/29/90. Negotiated settlement resulted in cancellation of all
indoor paint uses.
6(f) notice published 56 FR 105 on 5/31/91. Negotiated settlement resulted in cancellation of all
exterior paint uses. (Cancellation orders published 56 FR 31403 and 56 FR 31404 on 7/10/91.)
Notice of Intent to Cancel was published 59 FR 48430 on 9/21/94. A hearing was requested.
The FY95 expected output is a settlement of this litigation to include a change in classification of the
products that were subject to FY94 NOIC to restricted use products and a FR notice announcing classification
of the sewer use products as restricted use products and terminating the cancellation activity.
Voluntary cancellation/Cancellation order published 58 FR 4167 on 1/3/93. Cancellation order restricts sale
and distribution of existing stocks until additional data review is completed. Final decision expected by 5/93.
Voluntary Cancellation/Cancellation Order published 58 FR 4167 on 1/13/93. Cancellation order amendment
published 58 FR 30166 on 5/26/93 allowing conditional distribution, sale and use of existing stocks until
12/31/93. Second amendment to be published 59 FR 15410 on 4/1/94 extending stocks provision date until
12/31/94.
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4. Final Actions/Voluntary Cancellations (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
MEVINPHOS
Acute Worker Risk
All uses voluntarily cancelled July 1, 1994 allowing the distribution and sale through 12/31/94 and use until
2/28/95.
Cancellation published 59 FR 38973 on 8/1/94.
Existing stock provisions modified on 1/13/95 to allow distribution, sale, and use through 11/30/95.
Recall process of all mevinphos products, including products in the hands of growers, will commence on
12/1/95.
Amendment to cancellation published 60 FR 17351 on 4/5/95.
MONOCROTOPHOS
Avian Effects
MONURON
Carcinogenicity
NITROFEN (TOK)
Developmental
Toxicity
Carcinogenicity
Mutagenicity
OMPA (Octamethylpyrophosphoramide)
Carcinogenicity 41 FR 21859 (5/28/76).
All products voluntarily cancelled on 7/15/88.
42 FR 41320 (8/16/77). Some products cancelled.
All products voluntarily cancelled on 9/15/83.
Page 55
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Page 56
4. Final Actions/Voluntary Cancellations (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
PARATHION (ETHYL)
Acute Human
Poisoning
Avian
Negotiated settlement agreement resulted in voluntary cancellation of all but nine
field crop uses. 6(f) Notice published 56 FR 65061 on 12/13/91. Amendment permitting limited use
of existing stocks of cancelled products published 57 FR 3500 on 1/29/92.
PERTHANE
Carcinogenicity
PHENARSAZINE CHLORIDE
None
RONNEL
Carcinogenicity
SAFROLE
Carcinogenicity
Mutagenicity
SIMAZINE (Swimming Pool Uses)
Carcinogenicity
Chronic Effects
(Reduction in body weight gain,
hematological effects)
45 FR 41694 (6/20/80). Many products cancelled.
42 FR 59776 (11/21/77).
51 FR 2953 (1/22/86). Many products cancelled.
42 FR 11039 (2/25/77).
42 FR 16844 (3/30/77).
42 FR 29957 (6/10/77).
Notice of Cancellation of 17 product registrations published 59 FR 18120 on 4/15/94.
Notice of Cancellation of 1 product registration published 59 FR 27016 on 5/25/94.
Notice of Intent to Cancel for 4 product registrations published 59 FR 34614 on 7/6/94
because of unreasonable adverse effects on the environment. The Notice of Intent to Cancel became the final
cancellation order 30 days following its publication in the Federal Register.
-------
4. Final Actions/Voluntary Cancellations (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
SODIUM ARSENITE
Carcinogenicity
Mutagenicity
Developmental
Toxicity
SPOROCIDIN
Ineffective Sterilant Claims
STROBANE
Carcinogenicity
TRYSBEN
Carcinogenicity
WIPE OUT
Ineffective Sterilant
43 FR 48267 (10/18/78). Two products cancelled.
Stop Sale, Use and Removal Orders were issued in December 1991 due to product inefficacy and misbranding.
The registrant requested voluntary cancellation and a 6(f) notice was published 58 FR 37931 on 7/14/93.
41 FR 26607 (6/28/76).
43 FR 5782 (2/9/78).
Notice of Intent to Cancel published 58 FR 41779 on 8/5/93 due to Sterilant product's false
efficacy label claims. Registrant requested hearings, but withdrew from litigation in July 1997.
Wipe Out (#58994-1) cancelled for non-payment of registration maintenance fee on 7/28/97.
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5. Cancellations Issued Prior to RPAR/Special Review Process
Pesticide and Review Criteria
Possibly Met or Exceeded Final Determination
ALDRIN/DIELDRIN
Carcinogenicity 37 FR 37246 (10/18/74). Cancellation of all but termiticide use.
Bio-accumulation
Hazard to Wildlife
Other Chronic
Effects
CHLORDANE/HEPTACHLOR
Carcinogenicity 43 FR 12372 (3/24/78). Cancellation of all but termiticide use.
Reductions in
Non-target and
Endangered Species
CHLORDECONE (KEPONE)
Carcinogenicity 42 FR 18885 (4/11/77) and 42 FR 38205 (7/27/77). NTIS# PB80-216773.
ODD (TDE) (Dichlorodiphenyl dichloroethane)
Carcinogenicity 36 FR 5254 (3/18/71).
Bio-accumulation
Hazard to Wildlife and
Other Chronic Effects
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5. Cancellations Issued Prior to RPAR/Special Review Process (continued)
Pesticide and Review Criteria
Possibly Met or Exceeded
Final Determination
DDT (Dichlorodiphenyl trichloroethane)
Carcinogenicity 37 FR 13369 (7/7/72). Cancellation of most uses.
Bio-accumulation
Hazard to Wildlife
and Other Chronic
Effects
MIREX
Carcinogenicity
Bio-accumulation
Hazard to Wildlife
and Other Chronic Effects
41 FR 56703 (12/29/76).
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