United States Prevention, Pesticides EPA738-R-95-016
Environmental Protection And Toxic Substances July 1995
Agency (7508W)
4»EPA Reregistration
Eligibility Decision (RED)
Diquat Dibromide
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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20460
OFFICE OF
PREVENTION, PESTICIDES
AND TOXIC SUBSTANCES
CERTIFIED MAIL
Dear Registrant:
I am pleased to announce that the Environmental Protection Agency has completed its
reregistration eligibility review and decisions on the pesticide chemical case diquat dibromide
which icludes the active ingredient 6, 7-dihydrodipyrido(l,2-a:2',l,-c)pyrazinediium
dibromide. The enclosed Reregistration Eligibility Decision (RED) contains the Agency's
evaluation of the data base of these chemicals, its conclusions of the potential human health
and environmental risks of the current product uses, and its decisions and conditions under
which these uses and products will be eligible for reregistration. The RED includes the data
and labeling requirements for products for reregistration. It may also include requirements for
additional data (generic) on the active ingredients to confirm the risk assessments.
To assist you with a proper response, read the enclosed document entitled "Summary
of Instructions for Responding to the RED". This summary also refers to other enclosed
documents which include further instructions. You must follow all instructions and submit
complete and timely responses. The first set of required responses are due 90 days from
the date of this letter. The second set of required responses are due 8 months from the
date of this letter. Complete and timely responses will avoid the Agency taking the
enforcement action of suspension against your products.
If you have questions on the product specific data requirements or wish to meet with
the Agency, please contact the Special Review and Reregistration Division representative
Franklin Rubis at (703) 308-8184. Address any questions on required generic data to the
Special Review and Reregistration Division representative Kylie Rothwell at (703) 308-8055.
Sincerely yours,
Lois Rossi, Director
Special Review
and Reregistration Division
Enclosures
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SUMMARY OF INSTRUCTIONS FOR RESPONDING TO
THE REREGISTRATION ELIGIBILITY DECISION (RED)
1. DATA CALL-IN (PCI) OR "90-DAY RESPONSE" If generic data are required for
reregistration, a DCI letter will be enclosed describing such data. If product specific data
are required, a DCI letter will be enclosed listing such requirements. If both generic and
product specific data are required, a combined Generic and Product Specific DCI letter will
be enclosed describing such data. However, if you are an end-use product registrant only and
have been granted a generic data exemption (GDE) by EPA, you are being sent only the
product specific response forms (2 forms) with the RED. Registrants responsible for generic
data aree being sent response forms for both generic and product specific data requirements (4
forms). You must submit the appropriate response forms (following the instructions
provided) within 90 days of the receipt of this RED/DCI letter; otherwise, your product
may be suspended.
2. TIME EXTENSIONS AND DATA WAIVER REQUESTS No time extension requests
will be granted for the 90-day response. Time extension requests may be submitted only with
respect to actual data submissions. Requests for data waivers must be submitted as part of the
90-day response. Requests for time extensions for product specific data should be submitted
in the 90-day response. All data waiver and time extension requests must be accompanied by
a full justification. All waivers and time extensions must be granted by EPA in order to go
into effect.
3. APPLICATION FOR REREGISTRATION OR "8-MONTH RESPONSE" You must
submit the following items for each product within eight months of the date of this letter
(RED issuance date).
a. Application for Reregistration (EPA Form 8570-1). Use only an original
application form. Mark it "Application for Reregistration." Send your Application for
Reregistration (along with the other forms listed in b-e below) to the address listed in item 5.
b. Five copies of draft labeling which complies with the RED and current regulations
and requirements. Only make labeling changes which are required by the RED and current
regulations (40 CFR 156.10) and policies. Submit any other amendments (such as formulation
changes, or labeling changes not related to reregistration) separately. You may delete uses
which the RED says are ineligible for reregistration. For further labeling guidance, refer to
the labeling section of the EPA publication " General Information on Applying for Registration
in the U.S., Second Edition, August 1992" (available from the National Technical Information
Service, publication #PB92-221811; telephone number 703-487-4650).
c. Generic or Product Specific Data. Submit all data in a format which complies
with PR Notice 86-5, and/or submit citations of data already submitted and give the EPA
identifier (MRID) numbers. Before citing these studies, you must make sure that they meet
the Agency's acceptance criteria (attached to the DCI).
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d. Two copies of the Confidential Statement of Formula (CSF) for each basic and
each alternate formulation. The labeling and CSF which you submit for each product must
comply with P.R. Notice 91-2 by declaring the active ingredient as the nominal
concentration. You have two options for submitting a CSF: (1) accept the standard certified
limits (see 40 CFR §158.175) or (2) provide certified limits that are supported by the analysis
of five batches. If you choose the second option, you must submit or cite the data for the five
batches along with a certification statement as described in 40 CFR §158.175(e). A copy of
the CSF is enclosed; follow the instructions on its back.
e. Certification With Respect to Data Compensation Requirements. Complete and
sign EPA form 8570-31 for each product.
4. COMMENTS IN RESPONSE TO FEDERAL REGISTER NOTICE Comments
pertaining to the content of the RED may be submitted to the address shown in the Federal
Register Notice which announces the availability of this RED.
5. WHERE TO SEND PRODUCT SPECIFIC PCI RESPONSES (90-DAY) AND
APPLICATIONS FOR REREGISTRATION (8-MONTH RESPONSES)
By U.S. Mail:
Document Processing Desk (RED-SRRD-PRB)
Office of Pesticide Programs (7504C)
EPA, 401 M St. S.W.
Washington, D.C. 20460-0001
By express:
Document Processing Desk (RED-SRRD-PRB)
Office of Pesticide Programs (7504C)
Room 266A, Crystal Mall 2
1921 Jefferson Davis Hwy.
Arlington, VA 22202
6. EPA'S REVIEWS—EPA will screen all submissions for completeness; those which are not
complete will be returned with a request for corrections. EPA will try to respond to data
waiver and time extension requests within 60 days. EPA will also try to respond to all 8-
month submissions with a final reregistration determination within 14 months after the RED
has been issued.
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REREGISTRATION ELIGIBILITY DECISION
Diquat Dibromide
LIST A
CASE 0288
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
SPECIAL REVIEW AND REREGISTRATION DIVISION
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TABLE OF CONTENTS
DIQUAT DIBROMIDE REREGISTRATION ELIGIBILITY DECISION TEAM i
EXECUTIVE SUMMARY v
I. INTRODUCTION 1
II. CASE OVERVIEW 2
A. Chemical Overview 2
B. Use Profile 2
C. Estimated Usage of Pesticide 5
D. Data Requirements 6
E. Regulatory History 6
III. SCIENCE ASSESSMENT 6
A. Physical Chemistry Assessment 6
B. Human Health Assessment 7
1. Toxicology Assessment 7
a. Acute Toxicity 8
b. Subchronic Toxicity 8
c. Chronic Toxicity 10
d. Carcinogenicity 11
e. Developmental Toxicity 12
f. Reproductive Toxicity 15
g. Mutagenicity 16
h. Metabolism 17
i. Neurotoxicity 18
j. Other Toxicological Considerations 19
2. Exposure Assessment 20
a. Dietary Exposure 20
b. Occupational and Residential 27
3. Risk Assessment 31
a. Dietary Chronic Risk Analysis 31
b. Occupational and Residential 32
C. Environmental Assessment 36
1. Ecological Toxicity Data 36
a. Toxicity to Terrestrial Animals 36
b. Toxicity to Aquatic Animals 38
c. Toxicity to Plants 41
2. Environmental Fate 43
a. Environmental Fate Assessment 43
b. Surface Water Assessment 44
c. Environmental Fate and Transport 44
3. Exposure and Risk Characterization 47
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a. Ecological Exposure and Risk Characterization 47
b. Freshwater Invertebrates 57
c. Estuarine and Marine Animals 57
4. Exposure and Risk to Nontarget Plants 57
IV. RISK MANAGEMENT AND REREGISTRATION DECISION 60
A. Determination of Eligibility 60
1. Eligibility Decision 61
B. Regulatory Position 61
1. Tolerance Reassessment 61
2. Risk Mitigation Measures 69
3. Endangered Species Statement 69
4. Labeling Rationale 70
V. ACTIONS REQUIRED BY REGISTRANTS 74
A. Manufacturing-Use Products 74
1. Additional Generic Data Requirements 74
2. Labelling Requirements for Manufacturing-Use Products 74
B. End-Use Products 75
1. Additional Product-Specific Data Requirements 75
2. Labeling Requirements for End-Use Products 75
C. Spray Drift Label Advisory 80
D. Labeling for Endangered Species 83
E. Existing Stocks 83
VI. APPENDICES 85
APPENDIX A. Table of Use Patterns Subject to Reregistration 87
APPENDIX B. Table of the Generic Data Requirements and Studies Used to
Make the Reregistration Decision 143
APPENDIX C. Citations Considered to be Part of the Data Base Supporting the
Reregistration of Diquat Dibromide 155
APPENDIX D. List of Available Related Documents 173
APPENDIX E 177
PR Notice 86-5 179
PR Notice 91-2 201
APPENDIX F. Combined Generic and Product Specific Data Call-in 207
Attachment 1. Chemical Status Sheets 227
Attachment 2. Combined Generic and Product Specific Data Call-in
Response Forms (Form A inserts) Plus Instructions 231
Attachment 3. Generic and Product Specific Requirement Status and
Registrant's Response Forms (Form B inserts) and Instructions
237
Attachment 4. EPA Batching of End-Use Products for Meeting Data
Requirements for Reregistration 245
Attachment 5. EPA Acceptance Criteria 251
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Attachment 6. List of All Registrants Sent This Data Call-In (insert) Notice
265
Attachment 7. Cost Share, Data Compensation Forms, Confidential
Statement of Formula Form and Instructions 267
APPENDIX G. FACT SHEET 277
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DIQUAT DIBROMIDE REREGISTRATION ELIGIBILITY DECISION TEAM
Office of Pesticide Programs:
Biological and Economic Analysis Division
Phyllis Johnson
George W. Keitt
Eric Maurer
Environmental Fate and Effects Division
Mike Davy
Laura Parsons
Sharlene Matten
Health Effects Division
Arliene Aikens
Krystyna K. Locke
Jeff Evans
Felecia F. Fort
Labeling Use Information System
Biological Analysis Branch
Economic Analysis Branch
Ecological Effects Branch
Environmental Fate and Groundwater Branch
Science Analysis and Coordination Staff
Risk Characterization and Analysis Branch
Toxicology Branch I
Occupational and Residential Exposure Branch
Reregistration Support Chemistry Branch
Registration Division
Joanne Miller
Dan Kenny
Van Seabaugh
Special Review and Reregistration Division
Kylie Rothwell
Linda Propst
Fungicide-Herbicide Branch
Fungicide-Herbicide Branch
Registration Support Branch
Reregistration Branch
Reregistration Branch
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11
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GLOSSARY OF TERMS AND ABBREVIATIONS
AE Acid Equivalent
a.i. Active Ingredient
ADI Acceptable Daily Intake. A now defunct term for reference dose (RfD).
ARC Anticipated Residue Contribution
CAS Chemical Abstracts Service
CI Cation
CNS Central Nervous System
CSF Confidential Statement of Formula
DFR Dislodgeable Foliar Residue
ORES Dietary Risk Evaluation System
DWEL Drinking Water Equivalent Level (DWEL) The DWEL represents a medium specific (i.e. drinking
water) lifetime exposure at which adverse, non carcinogenic health effects are not anticipated to occur.
EEC Estimated Environmental Concentration. The estimated pesticide concentration in an environment, such
as a terrestrial ecosystem.
EP End-Use Product
EPA U.S. Environmental Protection Agency
FDA Food and Drug Administration
FIFRA Federal Insecticide, Fungicide, and Rodenticide Act
FFDCA Federal Food, Drug, and Cosmetic Act
GLC Gas Liquid Chromatography
GM Geometric Mean
GRAS Generally Recognized as Safe as Designated by FDA
HA Health Advisory (HA) The HA values are used as informal guidance to municipalities and other
organizations when emergency spills or contamination situations occur.
HOT Highest Dose Tested
LC50 Median Lethal Concentration. A statistically derived concentration of a substance that can be expected to
cause death in 50% of test animals. It is usually expressed as the weight of substance per weight or
volume of water, air or feed, e.g., mg/L, mg/kg or ppm.
LD50 Median Lethal Dose. A statistically derived single dose that can be expected to cause death in 50% of the
test animals when administered by the route indicated (oral, dermal, inhalation). It is expressed as a
weight of substance per unit weight of animal, e.g., mg/kg.
LDlo Lethal Dose-low. Lowest Dose at which lethality occurs
LEL Lowest Effect Level
LOG Level of Concern
LOD Limit of Detection
LOEL Lowest Observed Effect Level
MATC Maximum Acceptable Toxicant Concentration
MCLG Maximum Contaminant Level Goal (MCLG) The MCLG is used by the Agency to regulate
contaminants in drinking water under the Safe Drinking Water Act.
pg/g Micrograms Per Gram
mg/L Milligrams Per Liter
MP Manufacturing-Use Product
MPI Maximum Permissible Intake
MOE Margin of Exposure
NOEC No effect concentration
MRID Master Record Identification (number). EPA's system of recording and tracking studies submitted.
N/A Not Applicable
NPDES National Pollutant Discharge Elimination System
NOEL No Observed Effect Level
OP Organophosphate
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GLOSSARY OF TERMS AND ABBREVIATIONS
OPP Office of Pesticide Programs
PADI Provisional Acceptable Daily Intake
PAG Pesticide Assessment Guideline
PAM Pesticide Analytical Method
PHED Pesticide Handler's Exposure Data
PPE Personal Protective Equipment
ppb Parts Per Billion
ppm Parts Per Million
PRN Pesticide Registration Notice
Q*j The Carcinogenic Potential of a Compound, Quantified by the EPA's Cancer Risk Model
RBC Red Blood Cell
RED Reregistration Eligibility Decision
REI Restricted Entry Interval
RfD Reference Dose
RS Registration Standard
SLN Special Local Need (Registrations Under Section 24 (c) of FIFRA)
TC Toxic Concentration. The concentration at which a substance produces a toxic effect.
TD Toxic Dose. The dose at which a substance produces a toxic effect.
TEP Typical End-Use Product
TGAI Technical Grade Active Ingredient
TLC Thin Layer Chromatography
TMRC Theoretical Maximum Residue Contribution
torr A unit of pressure needed to support a column of mercury 1 mm high under standard conditions.
WP Wettable Powder
WPS Worker Protection Standard
IV
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EXECUTIVE SUMMARY
Reregistration Decision
This Reregistration Eligibility Decision document (RED) addresses the reregistration
eligibility of the pesticide diquat dibromide.
Diquat dibromide is a non-selective contact herbicide, desiccant and plant growth
regulator for use as a general herbicide for control of broadleaf and grassy weeds in terrestrial
non-crop and aquatic areas; as a desiccant in seed crops and potatoes; and for tassel control
and spot weed control in sugarcane. When used as a dessicant, diquat can be applied by
aircraft or ground equipment. In aquatic sites, diquat may be injected below the water surface
for submerged weeds, or sprayed for weed control along the edges of aquatic sites.
Applications in crop areas are made 5 days to two weeks before harvest. Diquat is used for
aquatic, indoor, greenhouse, and terrestrial food crops; aquatic non-food industrial, outdoor,
greenhouse and residential; terrestrial feed crops, and outdoor residential uses. Additional use
pattern information is described in the Profile section.
Based on the reviews of environmental fate, residue chemistry, toxicology, and
ecological effects data of the active ingredient diquat dibromide, the Agency has determined
that the uses of diquat dibromide as currently registered will not cause unreasonable risk to
humans or the environment. All currently registered uses are eligible for reregistration. The
Agency however is requiring additional terrestrial plant studies and an independent laboratory
validation of enforcement methods for plant and animal commodities.
Health Effects
Diquat dibromide is classified as Toxicity Category II for acute dermal toxicity and
primary eye irritation; Category III for acute oral and acute inhalation toxicity; and Category
IV for dermal irritation. Diquat dibromide is not a skin sensitizer.
Diquat dibromide is classified as a Group E carcinogen (evidence of non-
carcinogenicity for humans) based on a lack of evidence in acceptable animal studies. The
Reference Dose (Rfd) was determined to be 0.005 mg/kg/day, expressed as diquat cation,
based on the chronic toxicity study in dogs with a NOEL of 0.5 mg/kg/day, with an
uncertainty factor (UF)/safety factor (SF) of 100.
The registrant has proposed revised tolerances for soybeans, soybean hulls, alfalfa and
clover seed, sorghum grain, fish and shellfish, leafy and fruity vegetables, avocados,
cottonseed, hops and sugarcane, meat, milk and eggs. Furthermore, the registrant will submit
a label amendment request for the establishment of a preharvest interval (PHI) of 3 days for
alfalfa and clover seed.
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Occupational Safety
The Agency is concerned with the potential for postapplication/reentry exposure to
workers outside the scope of the Worker Protection Standard (WPS) occupational uses to
employees. In order to reduce the postapplication/exposure risks, the Agency is establishing a
4-day entry restriction to non-crop areas (other than aquatic sites) for non-WPS uses. For
occupational uses(WPS uses), the Agency requires a 7-day interim restricted entry interval
(REI). In addition, product use is limited to registered spot treatment for residential use. The
Agency is also concerned about post-application exposure to homeowners and is requiring a
product label requesting people and pets not to touch treated plants until the sprays have dried.
The registrant has proposed new enforcement methods for plant and animal
commodities. Both methods have been validated by the registrant, however, an independent
laboratory validation must be conducted followed by Agency validation.
There is an exposure potential for mixers, loaders, applicators or other handlers
during ordinary use, therefore the Agency requires closed mixing/loading of diquat liquid
formulations for aerial applications.
Environmental Fate and Ecological Effects
Diquat dibromide is immobile (binds irreversibly to the soil), is persistent, and will
accumulate in soil. Diquat dibromide exceeds the levels of concern (LOCs) for acute and
chronic effects to aquatic and estuarine organisms: however these effects are likely to be
minimal in actual practice because diquat dibromide tends to bind rapidly to suspended matter
in the water column and becomes biologically unavailable. Diquat dibromide exceeds the
levels of concern for chronic effects to birds and terrestrial mammals. The registrant has not
presented risk mitigation measures to reduce the chronic risk to birds.
The Agency is requiring additional ecological effects data, which include terrestrial
and aquatic plant studies needed to complete the risk assessment for diquat dibromide. The
registrant has submitted an aquatic plant study which is currently in review.
Before reregistering the products containing diquat dibromide, the Agency is requiring
that product specific data, revised Confidential Statements of Formula (CSF) and revised
labeling be submitted within eight months of the issuance of this document. These data include
product chemistry for each registration and acute toxicity testing. After reviewing these data
and any revised labels and finding them acceptable in accordance with Section 3(c)(5) of
FIFRA, the Agency will reregister a product. Those products which contain other active
ingredients will be eligible for reregistration only when the other active ingredients are
determined to be eligible for reregistration.
VI
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I. INTRODUCTION
In 1988, the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) was
amended to accelerate the reregistration of products with active ingredients registered prior to
November 1, 1984. The amended Act provides a schedule for the reregistration process to be
completed in nine years. There are five phases to the reregistration process. The first four
phases of the process focus on identification of data requirements to support the reregistration
of an active ingredient and the generation and submission of data to fulfill the requirements.
The fifth phase is a review by the U.S. Environmental Protection Agency (referred to as "the
Agency") of all data submitted to support reregistration.
FIFRA Section 4(g)(2)(A) states that in Phase 5 "the Administrator shall determine
whether pesticides containing such active ingredient are eligible for reregistration" before
calling in data on products and either reregistering products or taking "other appropriate
regulatory action." Thus, reregistration involves a thorough review of the scientific data base
underlying a pesticide's registration. The purpose of the Agency's review is to reassess the
potential hazards arising from the currently registered uses of the pesticide; to determine the
need for additional data on health and environmental effects; and to determine whether the
pesticide meets the "no unreasonable adverse effects" criterion of FIFRA.
This document presents the Agency's decision regarding the reregistration eligibility
of the registered uses of diquat dibromide. The document consists of six sections. Section I is
the introduction. Section II describes diquat dibromide, its uses, data requirements and
regulatory history. Section III discusses the human health and environmental assessment based
on the data available to the Agency. Section IV presents the reregistration decision for diquat
dibromide. Section V discusses the reregistration requirements for diquat dibromide. Finally,
Section VI is the Appendices which support this Reregistration Eligibility Decision. Additional
details concerning the Agency's review of applicable data are available on request.
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II. CASE OVERVIEW
A. Chemical Overview
The following active ingredient is covered by this Reregistration
Eligibility Decision:
• Common Name: diquat dibromide
Chemical Name: 6,7-dihydrodipyrido(l,2-a:2',r-c)pyrazinediium
dibromide
Chemical Family: Bipyridylium, dipyridylium
CAS Registry Number: 85-00-7
OPP Chemical Code: 032201
Empirical Formula: C12H12Br2N2
Trade and Other Names: Reglone, Weedkiller Cone. D, Aquacide,
Dextrone, FB 2, Reglox, Weedtrine D,
Reward
Basic Manufacturer: Zeneca Ag Products
B. Use Profile
The following is information on the currently registered uses with an
overview of use sites and application methods. A detailed table of these uses of diquat
dibromide is in Appendix A.
For Diquat Dibromide:
Type of Pesticide: algicide, defoliant, desiccant, herbicide
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Use Groups and Sites:
AQUATIC FOOD CROP
Agricultural drainage systems, irrigation systems, lakes/ponds/reservoirs (with human or
wildlife use)
AQUATIC NON-FOOD INDUSTRIAL
Drainage systems, lakes/ponds/reservoirs (without human or wildlife use)
AQUATIC NON-FOOD OUTDOOR
Aquatic areas/water, intermittently flooded areas/water, streams/rivers/channeled water
AQUATIC NON-FOOD RESIDENTIAL
Ornamental ponds/aquaria
GREENHOUSE FOOD CROP
Greenhouse-in use
INDOOR FOOD
Storage areas-empty and full
INDOOR NON-FOOD
Greenhouse-empty
OUTDOOR RESIDENTIAL
Residential lawns, household/domestic dwellings outdoor premises
TERRESTRIAL FEED CROP
Alfalfa, bermudagrass, clover
TERRESTRIAL FOOD CROP
Carrot (including tops), cucumber, melons (cantaloupe), melons (water), pepper, radish,
squash (all or unspecified), turnip
TERRESTRIAL FOOD + FEED CROP
Potato (white/irish), sorghum, soybeans (unspecified), tomato
TERRESTRIAL NON-FOOD CROP
Agricultural fallow/idleland, agricultural/farm structures/buildings and equipment, agricultural
rights-of-way/fencerows/hedgerows, agricultural uncultivated areas, airports/landing fields,
commercial/industrial lawns, commercial/institutional/industrial premises/equipment
(outdoor), golf course turf, industrial areas (outdoor), nonagricultural outdoor
buildings/structures, nonagricultural rights-of-way/fencer ows/hedgerows, nonagricultural
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uncultivated areas/soils, nonagricultural uncultivated soil sterilization, ornamental and/or
shade trees, ornamental woody shrubs and vines, recreation area lawns, recreation areas
TERRESTRIAL NON-FOOD + OUTDOOR RESIDENTIAL
commercial/institutional/industrial premises/equipment (outdoor), fencerows/hedgerows,
ornamental and/or shade trees, nonagricultural outdoor buildings/structures, nonagricultural
rights-of-way/fencerows/hedgerows, nonagricultural uncultivated soil sterilization, ornamental
herbaceous plants, ornamental lawns and turf, ornamental flowering plants, ornamental woody
shrubs and vines, paths/patios, paved areas (private roads/sidewalks)
Target Pests: algae: pithophora, spirogyra; weeds: bladderwort, crabgrass, elodea,
jimsonweed, leafy spurge, naiad, poison ivy, salvinia, shepherdspurse, waterlettuce;
desiccant/defoliant of seed crops: alfalfa, carrot (including tops), clover, potato (white/irish),
radish, sorghum, turnip
Formulation Types Registered:
Single active ingredient
Liquid-Ready to Use-0.0940 to 0.2300% diquat
Soluble Concentrate/Liquid-0.1900 to 37.45% diquat
Manufacturing Use—35.3 to 37.45% diquat
Multiple active ingredient
Liquid-Ready to Use-0.1540% diquat + 1 other AI
Method and Rates of Application:
Soluble Concentrate/Liquid
For desiccation of seed crop, apply by ground or aircraft at 0.5 Ib diquat cation (CI) per acre,
or apply to tomatoes at post-final harvest as a spray at .375 Ib (CI) in FL, GA and PR; or for
golf course treatment, apply as needed with sprayer at 0.008 to 1.0 Ib (CI), or for pre-
renovation apply as a desiccation ground application at 1 Ib (CI); or apply when needed as
water subsurface treatment by injection or by boat at 4 Ib (CI) per acre, or up to 4.2 Ib (CI)
per acre foot.
Liquid-Ready to Use
Apply to household/domestic dwellings, outdoor premises or nonagricultural outdoor
buildings/structures as edging or spot treatment - or apply to woody shrubs and vines,
paths/patios, and paved areas (private roads/sidewalks as directed spray, edging or spot
treatment) - when needed with sprayer at .05 Ib (CI)/1000 square feet: or apply to ornamental
woody shrubs and vines with hand held or mehanical sprayer as a spray when needed at .02
Ib (CI)/1000 square feet.
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Use Practice Limitations:
(Please refer to Appendix A for a list of use limitations.)
C.
Estimated Usage of Pesticide
This section summarizes the best estimates available for the pesticide uses of diquat
dibromide. These estimates are derived from a variety of published and proprietary sources
available to the Agency. The data, reported on an aggregate and site (crop) basis, reflect
annual fluctuations in use patterns as well as the variability in using data from various
information sources.
The table below summarizes the pesticide use by site.
Percent of Various U.S. Crops Treated Annually with Diquat Dibromide, 1990 - 1992
Site/1
Alfalfa
Cantaloupe
Clover
Cucumber
Ornamentals
Pepper
Potato
Sorghum
Tomato
Watermelon
Other/4
TOTAL
Acres Grown/2
(000)
25,048
131
146
132
597
93
1,378
11,625
475
251
N/A
Acre Treatments/3
(000)
low - high
25 - 105
1 - <5
2- <5
1 - <5
50-75
10- 15
300 - 500
5- 10
5-23
1 -5
N/A - N/A
400 - 748
Percent Crop
Treated
low - high
<1 -<1
1 - <5
1 - <5
1 - <5
8- 13
11 - 16
22-36
<1 - <1
1 -5
<1 -2
N/A
Pounds
a.i./ac
low -high
15-60
1 - <5
2- <5
1 - 1
45-55
1 - <5
175 - 275
1 -5
4- 15
1 - <5
150-250
396 - 681
/I - Site identification based on REFS.
12 - Based on USDA/NASS publications from 1990 - 1993.
/3 - Acre treatments represent the number of acres treated times the number of applications.
/4 - Includes home and garden, non-crop, and aquatic uses; acre treatments are difficult to quantify because of spot
treatments.
There are no known site specific usage data available for turnip.
There is no known usage on carrots, radishes, soybeans, squash, and sugarcane.
Data based on proprietary sources, USD A, Zeneca Ag, Inc., and state statistics.
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D. Data Requirements
Data requested in the June 1986 Registration Standard for diquat dibromide include
studies on product chemistry, ecological effects, health effects, environmental fate, toxicology,
and residue chemistry. These data were required to support the uses listed in the Registration
Standard. In 1991, the Data Call-In (DCI) notice required toxicology, ecological effects,
environmental fate and residue chemistry studies. Appendix B includes all data requirements
identified by the Agency for currently registered uses needed to support reregistration.
E. Regulatory History
Diquat dibromide is the accepted common name for 6,7-dihydrodipyrido
(l,2-a:2',l'-c) pyrazinediium dibromide. It is manufactured by Zeneca, Inc. and is marketed
under the trade name Diquat. Currently, there are forty-three active products containing diquat
dibromide which are registered under Section 3 of the Federal Insecticide, Fungicide, and
Rodenticide Act.
In June, 1986, EPA issued a Registration Standard for products containing diquat
dibromide as an active ingredient (NTISf PB87-105490). A Pesticide Fact Sheet for diquat
dibromide was issued in June, 1987 (NTISf PB92-126986). These documents provide a
summary and the rationale of the regulatory position for diquat dibromide.
III. SCIENCE ASSESSMENT
A. Physical Chemistry Assessment
1. Identification of the Active Ingredient
Diquat dibromide [6,7-dihydrodipyrido(l,2-a:2',r-c)pyrazinediium dibromide] is a
non-selective contact herbicide, desiccant, and plant growth regulator. Pure diquat dibromide
is an odorless yellow solid with a melting point of ca. 300°C. Diquat dibromide is very
soluble in water (700 g/L at 20°C), slightly soluble in alcohol and hydroxylic solvents, and
practically insoluble in non-polar organic solvents. Diquat dibromide decomposes under basic
conditions and is susceptible to ultraviolet decomposition. The molecular structure of diquat
dibromide is:
2Br
Empirical Formula: C12H12Br2N2
Molecular Weight: 344.0
CAS Registry No.: 85-00-7
Shaughnessy No.: 032201
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There are four EPA manufacturing use product (MPs) registrations for diquat dibromide (Reg.
No(s): 10182-378 (37.45% ai); 10182-354 (37.45% ai); 10182-355 (35.3% ai) and 10182-376
(35.3% ai). None of the physical/chemical data requirements are satisfied for EPA Reg. No.
10182-355 or EPA Reg. No. 10182-354. The outstanding physical/chemical data
requirements are specified in the data tables (Appendix B). In addition, the registrant must
either certify that the suppliers of starting materials and the manufacturing processes for diquat
dibromide MPs have not changed since the last comprehensive product chemistry review or
submit a complete updated product chemistry data package.
2. Other Product Chemistry Issues
The manufacture of diquat dibromide may result in the occurrence of ethylene dibromide
(EDB) as a process impurity in final formulations because EDB is a starting material in the
manufacture of diquat dibromide. EDB is considered a carcinogen, and all pesticide uses of
EDB were canceled. Since EDB may remain in diquat dibromide formulations, potential
exposure risks were assessed (Guidance Document, 6/86). The Agency concluded that the
presence of EDB, which may result from the use of diquat dibromide in aquatic and terrestrial
sites, does not pose a significant dietary risk, based on worst case assessments. In addition,
the registrant certified an upper certified limit of 10 ppb for EDB in diquat dibromide, and
demonstrated that EDB does not persist as an impurity in diquat dibromide and will slowly
dissipate over time.
B. Human Health Assessment
1. Toxicology Assessment
The toxicological data base on diquat dibromide is adequate and will
support reregistration eligibility.
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a. Acute Toxicity
Acute Toxicity
Test
Acute Oral LD50
(rat)1
Acute Dermal LD50
(rabbit)2
Acute Inhalation LC50
(rat)3
Eye Irritation
(rabbit)4 *
Dermal Irritation
(rabbit)5 *
Skin Sensitization
(guinea pig)6 *
Results
0.81 g/kg d-
0.60 g/kg ?
262.0 mg/kg
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useful information "to indicate that diquat dibromide is toxic via repeated dermal exposure."
(MRID 00140576)
In a repeated dose dermal toxicity study, male and female Spraque-Dawley rats,
6/sex/group, were exposed (intact skin) to technical diquat dibromide for 3 weeks (6
hours/day, 7 days/week). The dose levels used, expressed as diquat cation, were 0, 5, 20, 40
or 80 mg/kg of body weight/day and were based on the results of two preliminary studies.
Treatment-related effects included high mortality in the 40 mg/kg female group (67%) and in
the 80 mg/kg male (83%) and female (100%) groups; decreased weight gain for the 80 mg/kg
males and females; decreased food consumption, for the 80 mg/kg males (11-36%) and
females (3-41%); hypothermia, hypoactivity, dyspnea, cyanosis, pale extremities, general
poor condition and an emaciated appearance, all in the nonsurvivors; dermal irritation
(erythema, edema, atonia and desquamation) and tissue destruction (necrosis and eschar
formation) at the application site, at all dose levels, sores, severe erythema, fissures, acute
necrotizing purulent dermatitis, and degeneration of hair follicles and sebaceous glands, all at
the application site in the 20, 40 and 80 mg/kg male and female groups; and congestion in the
lungs, liver and kidneys, mostly in the nonsurvivors from the 40 and 80 mg/kg male and
female groups. Based on the above findings, the NOEL and LOEL for systemic toxicity, for
both sexes, are 5 mg diquat cation/kg/day and 20 mg diquat cation/kg/day, respectively. The
NOEL for dermal toxicity, for both sexes, is < 5 mg diquat cation /kg/day (LDT). (MRID
40308101)
In a repeated dose inhalation toxicity study, groups of 10 male and 10 female Fischer
344 rats were exposed (whole body) to respirable aerosols of Diquat Concentrate (technical
diquat) for 3 weeks (6 hours/day, 5 days/week). The exposure concentrations (analytical)
were 0, 0.49, 1.1 or 3.8 ug/L, expressed as diquat cation, and were based on the results of a
preliminary inhalation study. A satellite group of the control and high-dose males and females
was treated similarly and then observed for 3 weeks for reversibility of toxic effects. The
average mass median aerodynamic diameter of the aerosols was 1.9, 1.7 and 1.7 um in the
low- mid- and high-concentrations groups, respectively. Because whole animals were exposed
to diquat, the animals, including controls, were rinsed with tap water for about 5 seconds and
blotted dry after each exposure before they were returned to their cages in the housing area.
The purpose of the rinse was to remove diquat which had deposited on the animals' fur and to
minimize any oral exposure to diquat which could occur from grooming. Treatment-related
effects, observed at the lowest concentration of diquat cation tested (0.49 ug/L), included
significant (p< 0.01) increases in the mean lung weight (18%), and the lung/body weight
(18%) and the lung/brain weight (19%) ratios for the male rats; mottling and reddening of the
lungs in the females; and the lung lesions (multi-focal chronic interstitial pneumonia and
alveolar macrophages) in the males and females. All toxic effects, except mottling and
reddening of the lungs, were reversible during the 21-day recovery period (satellite group).
Considering the above findings, the NOEL for subchronic (21 days) inhalation toxicity is <
0.49 ug/L, expressed as diquat cation (LDT). (MRID 40301701)
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In a second repeated dose inhalation toxicity study, groups of 10 male and 10 female
Fischer 344 rats were exposed (whole body) to respirable aerosols of Diquat Concentrate
(technical diquat) for 3 weeks (6 hours/day, 5 days/week). The exposure concentrations used
were 0 and 0.1 ug/L, expressed as diquat cation, and the average mass median aerodynamic
diameter of the aerosols was 1.5 um. This study was conducted in the same manner as an
earlier study (MRID 40301701) in which three concentrations of diquat cation were used
(0.49, 1.1 or 3.8 ug/L), but in which the NOEL was not determined. Therefore, in order to
establish the NOEL and LOEL for the 21-day inhalation exposure, both studies should be
considered together. In the current study, the only concentration of diquat cation tested (0.1
ug/L) had no effect on any of the parameters examined. In the earlier study (MRID
40301701), toxic effects were observed at the lowest concentration of diquat cation tested
(0.49 ug/L). Therefore, for the repeated 21 days inhalation exposure, the NOEL and LOEL
for both sexes are 0.1 ug/L and 0.49 ug/L, respectively, expressed as diquat cation. (MRID
40640801)
c. Chronic Toxicity
A chronic feeding/carcinogenicity study was conducted using Sprague-Dawley rats
which were fed diets containing 0, 5, 15, 75 or 375 ppm of diquat cation for 104 weeks.
These dose levels were equivalent toO, 0.19, 0.58, 2.91 or 14.88 mg/kg/day (males) and 0,
0.24, 0.72, 3.64 or 19.44 mg/kg/day (females) of diquat cation (analytical values), and were
based on a 4-week preliminary study. There were 60 rats/sex in each group. The interim
sacrifice (10 rats/sex/group) took place at 52 weeks. With the exception of minimal lens
opacity (cataracts), in 7/52 (13%) male rats and 3/41 (7%) female rats which died or were
sacrificed moribund in the 5 ppm and 15 ppm groups during weeks 79-104, nothing
remarkable was observed in these groups. Treatment-related effects in the 75 ppm group
were: lens opacity in 4/9 (44%) males and 6/10 (60%) females which were sacrificed at week
52 (interim sacrifice); lens opacity in 19/21 (90%) males and 15/20 (75%) females, and
marked or severe cataracts in 5/21 (14%) males and 7/20 (10%) females which were sacrificed
at the termination of the study; lens opacity in 12/28 (43%) males and 16/30 (53%) females,
and marked or severe cataracts in 4/28 (14%) males which died or were sacrificed during
weeks 53-104; and extralenticular lesions (vitreous adhesions, retinal detachment and
synechia) in 4-6/59 (7-10%) males and 1-3/60 (2-5%) females during the entire study. The
systemic NOEL for both sexes is 15 ppm (0.58 mg/kg/day for males and 0.72 mg/kg/day for
females, expressed as diquat cation); and the systemic LOEL is 75 ppm (2.91 mg/kg/day for
males and 3.64 mg/kg/day for females, expressed as diquat cation). (MRID 00145855),
(MRID 00155474 - amended pages to replace pages 145 and 146 of the original report,
MRID 00145855) and (MRID 40185601 - 4-week preliminary study).
Groups of 4 male and 4 female beagle dogs were administered technical grade diquat
dibromide in the diet for 52 weeks. Male dogs received daily 400 g and females 350 g of the
diquat-containing pellets. The dose levels used were 0, 0.5, 2.5 or 12.5 mg/kg/day, expressed
as diquat cation, and were based on the results of previous toxicity studies with diquat
dibromide (details were not provided). Nothing remarkable was observed in the 0.5 mg/kg
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male and female groups. Treatment-related effects in the 2.5 mg/kg group included unilateral
cataracts in two females; decreased mean adjusted weight of the adrenals in the males (13.8%;
p< 0.05) and decreased mean absolute weight (16.2%; p< 0.05) and adjusted weight (16.1%;
p < 0.05) of the epididymides in the males. Diquat was not detected in the plasma of dogs from
the 0.5 mg/kg group. In the 2.5 mg/kg group, diquat was detected in the plasma of most dogs
only after feeding (concentrations of diquat cation detected: 21-43 ng/mL in the males and 20-
54 ng/mL in the females). In the 12.5 mg/kg group, diquat was detected in the plasma of
most dogs before and after feeding. The concentrations of diquat cation detected before
feeding were: 21-59 ng/mL in the males and 23-186 ng/mL in the females. The
concentrations of diquat cation detected after feeding were: 24-153 ng/mL in the males and
44-255 ng/mL in the females. Based on the above findings, systemic NOEL for both sexes is
0.5 mg/kg/day and systemic LOEL is 2.5 mg/kg/day. (MRID 41730301)
d. Carcinogenicity
A chronic feeding/carcinogenicity study was conducted using Sprague-Dawley rats
which were fed diets containing 0, 5, 15, 75 or 375 ppm of diquat cation for 104 weeks.
These dose levels were equivalent to 0, 0.19, 0.58, 2.91 or 44.88 mg/kg/day (males) and 0,
0.24, 0.72, 3.64 or 19.44 mg/kg/day (females) of diquat cation (analytical values). There
were 60 rats/sex in each group.
The interim sacrifice (10 rats/sex/group) took place at week 52. During the initial
review of this study, there were some concerns about the carcinogenic potential of diquat for
the following reasons: there were statistically significant increases in several tumor types at
single dose level, although dose-related trends were lacking and there were increased
incidences of some rare tumors, but the statistical significance was lacking. The tumor types
in question, all in the male rats, were hepatocellular adenomas/carcinomas; benign/malignant
pheochromocytomas and mixed medullary tumors of the adrenal gland; follicular and
parafollicular cell adenomas/carcinomas of the thyroid; squamous carcinomas of the Zymbal
gland; and osteosarcomas of the bone. However, following an evaluation of the submitted
historical control data, the Agency concluded that diquat was not carcinogenic with respect to
all neoplasms but osteosarcomas. The incidence of osteosarcomas in the 0 (control), 5, 15, 75
and 375 ppm male groups was 0/50, 1/50 (2%), 0/50, 0/50 and 3/49 (6%)*, respectively,
whereas the historical control incidence was 0-2%. Because the historical control incidence
was lower than the observed incidence in this study and because osteosarcomas of the bone
were rare tumors, the decision concerning the carcinogenic potential of diquat was determined
by the Health Effects Division RfD/Peer Review Committee. [* During repeated examination
of the individual histopathology data, only 2/49 (4%) osteosarcomas and not 3/49 (6%) as
reported in the summary tables of the submitted report were found. One rat died during week
96 and another during week 100]. (MRID 00145855), (MRID 00155474 - amended pages to
replace pages 145 and 146 of the original report, MRID 00145855), (MRID 00160673 -
historical control data for neoplastic lesions) and (MRID 40185602 - registrant's comments on
the incidence of osteosarcoma).
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Groups of CD-I mice (60/sex/dose) were administered technical diquat dibromide in
the diet for at least 104 weeks. The dose levels used were 0, 30, 100 or 300 ppm, expressed
as diquat cation, and were based on the results from previous feeding studies with the same
strain of mice. These levels, expressed as diquat cation, were equivalent to 0, 3.56, 11.96 or
37.83 mg/kg/day for males and 0, 4.78, 16.03 or 48.27 mg/kg/day for females. Nothing
remarkable was observed in the 30 ppm male and female group. Treatment-related effects in
the 100 ppm group were: increased number of males (25%) with eye discharge; decreased
body weight gains (11-13%; p<0.01) in the males during weeks 93-105; increased kidney
weight, adjusted for body weight, in the males (6%; p< 0.01); slight increase in the incidence
of tubular dilatation of the kidneys in the males (3/60) and females (4/60) when compared with
the controls (1/60, males and females); increased incidence of tubular hyaline droplet
formation in the kidneys of the females (10/60; controls: 3/60); and increased incidence of
lymphoid proliferation in the mesenteric lymph node of the females (13/59; controls: 9/60).
Based on the above findings, systemic NOEL (diquat cation) for both sexes is 30 ppm (males:
3.56 mg/kg/day and females: 4.78 mg/kg/day). The systemic LOEL (diquat cation),
therefore, is 100 ppm (males: 11.96 mg/kg/day and females: 16.03 mg/kg/day). Diquat was
not carcinogenic in this study. The number of tumor-bearing mice was the same in the control
and diquat-treated male groups. In the females, there was a reduction in the number of tumor-
bearing mice in the mid-dose (100 ppm) and high-dose (300 ppm) groups, relative to the
controls. Most of the tumor-bearing mice in each group, including the controls, had single,
malignant and metastatic tumors. (MRID 42219801 - main study) and (MRID 42880701,
42905901, and 42919501 - supplemental data).
The carcinogenic potential of diquat dibromide was evaluated by the Health Effects
Division Reference Dose (RfD)/Peer Review Committee on March 31, 1994. The Committee
classified diquat dibromide into Group E (evidence of noncarcinogenicity for humans), based
on a lack of evidence of carcinogenicity in acceptable studies with two animal species, rat and
mouse. The dose levels tested in both studies were considered to be adequate for
carcinogenicity testing. This conclusion was based on moderate reduction in body weight gain
in both rats and mice, and on histopathological changes (lens opacity, severe cataracts and
extralenticular lesions) in the eyes of rats. The slight increase in the incidence of
osteosarcoma of the bone in the high-dose male rats above the concurrent and historical
control incidence was regarded as spontaneous rather than diquat-related. This increase
attained a statistically significant positive trend, but was not statistically significant in the pair-
wise comparison with the concurrent controls.
e. Developmental Toxicity
A developmental study was conducted in which diquat dibromide was administered to
pregnant Sprague-Dawley rats (18-20/ group) in their diets throughout gestation (days 1-20).
The dose levels used were 0, 125 or 500 ppm, expressed as diquat cation. Based on
calculations from the actual food consumption and body weight data, these values were
equivalent to 0, 8-14 or 32-56 mg of diquat cation/kg/day, respectively. Maternal toxicity was
observed only in the 500 ppm group and included decreases in mean total body weight gain
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(31%; p< 0.01), mean total food consumption (20%; p< 0.01) and food efficiency (4%),
when compared with the controls. Developmental toxicity was also observed only in the 500
ppm group and included decreased fetal weight (8%; p < 0.01) and instances of various
external, visceral and skeletal alterations. Based on these findings, the NOEL and LOEL for
maternal toxicity are 8-14 mg/kg/day and 32-56 mg/kg/day, respectively. The NOEL and
LOEL for developmental toxicity are also 8-14 mg/kg/day and 32-56 mg/kg/day, respectively.
Because of various deficiencies in the reporting of this study (no data on the number of
corpora lutea per dam, pregnancy status and preimplantation losses; and no individual data for
maternal, fetal and litter weights, number of implantation, live fetuses, early and late
resorptions, and incidences of external, visceral and skeletal alterations), this study should be
classified as supplementary. However, this study could be used in conjunction with other
developmental toxicity studies with diquat to support reregistration of the pesticide.
(Accession No. 224405)
In another recently submitted developmental toxicity study, diquat dibromide was
administered by gavage, in deionized water, to pregnant Wistar-derived rats (23-24/group)
from gestation day 7 through 16. The dose levels used were 0, 4, 12 or 40 mg/kg/day,
expressed as diquat cation. Animals were sacrificed on gestation day 22 and uteri were
examined for live fetuses and intrauterine deaths. The lowest dose (4 mg/kg/day) was
associated with decreased maternal body weight gain (22%; p< 0.05) and food consumption
(7%; p < 0.05) during the first three days of dosing only, when compared with the controls.
Treatment-related findings in the high-dose group were: decreases in fetal (9%; p< 0.01) and
litter (12%; p < 0.05) weights; increased incidence of fetuses with hemorrhagic kidney (5 in 4
litters; p< 0.05), compared with none in the control group; partially ossified second sternebra
in 26 fetuses from 6 litters (p< 0.01), compared with 2 fetuses in 2 litters in the control
group; partially ossified fifth sternebra in 89 fetuses from 19 litters (p< 0.01), compared with
69 fetuses in 19 litters in the control group; unossified ventral tubercle in 26 fetuses from 11
litters (p< 0.05), compared with 17 fetuses in 8 litters in the control group; and unossified
centra of the second through fifth cervical vertebrae, as follows (number of fetuses
affected/number of litters involved in the high-dose group versus (vs) those in the controls):
2nd vertebrae - 180/23 (p<0.05) vs 162/24; 3rd vertebrae -- 88/18 (p<0.05) vs 39/16;
4th vertebrae -- 56/17 (p<0.01) vs 21/11; and 5th vertebrae -- 23/10 (p<0.01) vs 12/7.
Based on the above findings, the NOEL for maternal toxicity is not established and the LOEL
is <_ 4mg/kg/day, expressed as diquat cation (lowest dose tested). The developmental toxicity
NOEL and LOEL are, respectively, 12 mg/kg/day and 40 mg/kg/day (highest dose tested),
expressed as diquat cation. (MRID 41198902)
Pregnant Dutch rabbits (15-20/group) were treated with diquat dibromide on gestation
days 1 through 28. The test material was administered by gavage at dose levels of 0, 1.25,
2.5 or 5.0 mg/kg/day, expressed as diquat cation. The animals were sacrificed on gestation
day 29 and examined to determine the numbers of implantation sites, resorptions, and live and
dead fetuses. Decreased body weight gain in the 5 mg/kg group was the only maternal
toxicity observed in this study. The food consumption data were not reported. There was no
indication of a dose-related effect of diquat administration on fetal development, but there
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appeared to be a treatment-related increase in the early resorption rate. Historical control data
were not submitted to determine if the early resorption rate reported for the concurrent control
group was unusually low for the Dutch strain of rabbit. Based on these findings, the NOEL
and LOEL for maternal toxicity are 2.5 mg/kg/day and 5.0 mg/kg/day, respectively,
expressed as diquat cation, but the NOEL for developmental toxicity cannot be clearly
established. Because of the marginal number of pregnancies available for evaluation in this
study (10 or 11 per group) and the reporting deficiencies (no data on the number of corpora
lutea per doe, pregnancy status and preimplantation losses; no individual data, by litter, on the
incidences of external, visceral and skeletal alterations; and no statistical analyses and
historical control data), this study should be classified as supplementary. However, this study
could be used in conjunction with other developmental toxicity studies with diquat to support
reregistration of the pesticide. (MRID 00061635)
In another recently submitted developmental toxicity study, diquat dibromide in
deionized water, was administered by gavage, to pregnant New Zealand white rabbits
(20/group) from gestation day 7 through 19. The dose levels used were 0, 1, 3 or 10
mg/kg/day, expressed as diquat cation. Animals were sacrificed on gestation day 30 and uteri
were examined for live fetuses and intrauterine deaths. Nothing remarkable was observed in
the low-dose (1 mg/kg/day) group. The mid-dose group (3 mg/kg/day) was associated with
decreased maternal body weight gain (229% less than controls; p< 0.01) and food
consumption (45% less than controls; p< 0.01) which were observed only during the first
three days of dosing. The high-dose group (10 mg/kg/day) showed greater decreases in body
weight gain (343%; p< 0.01) and food consumption (74%; p< 0.01) than the mid-dose group
during the first three dosing days and the decreases continued throughout the dosing period.
Developmental effects were observed only in the high-dose group and included an increased
incidence of fetuses with friable livers (14 in 3 litters, p < 0.05, compared with 8 in 5 litters
in the control group) and mottled livers (12 in 3 litters, p< 0.05, compared with 8 in 6 litters
in the controls). Fetuses from the high-dose group also exhibited poorer ossification as
indicated by higher incidences of minor skeletal alterations, including partially ossified ventral
tubercle of cervical vertebrae (10 fetuses in 5 litters, p< 0.01, compared with 1 fetus in 1
litter in the control group); partially ossified sixth sternebra (16 fetuses in 8 litters, p< 0.01,
compared with 9 fetuses in 6 litters in the controls); and unossified sixth sternebra (6 fetuses
in 5 litters, p < 0.01, compared with zero incidence in the control group). Also, the frequency
of the skeletal variant, 27 presacral vertebrae, was increased in the high-dose group (49
fetuses in 12 litters, p< 0.01, compared with 46 fetuses in 14 litters in the controls), but this
increase was within recent historical control incidence. Based on the above findings, the
NOEL and LOEL for maternal toxicity are 1 mg/kg/day and 3 mg/kg/day, respectively,
expressed as diquat cation. The developmental toxicity NOEL and LOEL are, respectively, 3
mg/kg/day and 10 mg/kg/day (highest dose tested), expressed as diquat cation. (MRID
41198901)
A developmental study was conducted in which an aqueous solution of diquat
dibromide was administered by gavage to pregnant Alderley Park strain SPF albino mice (32-
34/group) from gestation day 6 through 15. The dose levels used were 0, 1, 2 or 4
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mg/kg/day, expressed as diquat cation. Animals were sacrificed on gestation day 17. Nothing
remarkable was observed in the low-dose group. Toxic signs noted in the mid-dose and high-
dose groups were piloerection, dyspnea, respiratory noise and abnormal posture (hunched or
tail raised), whereas none of these signs were observed in the control group. Relative to the
control value, a decreased body weight gain was also reported for the mid-dose (23%) and
high-dose (29%) group. Excluding the intubation errors, there were no unscheduled deaths in
the control group, but 3/33 (9%) and 5/34 (15%) animals died in the mid-dose and high-dose
groups, respectively. Developmental toxicity was observed only in the high-dose group and
included statistically significant (p< 0.05) decreased fetal body weight (12% below the
control group mean) and increased incidence of overall skeletal alterations (16/23 affected
litters, compared with 9/27 litters in the control group). Based on these findings, the NOEL
and LOEL for maternal toxicity are 1 mg/kg/day and 2 mg/kg/day, respectively, expressed as
diquat cation. The developmental toxicity NOEL and LOEL are, respectively, 2 mg/kg/day
and 4 mg/kg/day (highest dose tested), expressed as diquat cation. (MRID 00061637)
f. Reproductive Toxicity
Wistar-derived rats (30 males and 30 females/group) were fed diets containing diquat
dibromide at dose levels equivalent to 0, 16, 80 or 400/240 ppm of diquat cation. Based on
the commonly used conversion factor of 1 ppm = 0.05 mg/kg for an older rat these levels
were equivalent to 0, 0.8, 4 or 20/12 mg/kg/day, respectively. The F0 high-dose group
received diets containing 400 ppm of diquat cation. Due to adverse effects in the F1 animals,
the dose was reduced from 400 ppm to 240 ppm approximately four weeks after selection.
The feeding of the test material was started 12 weeks (11 weeks for the F1 generation) before
mating and was continued through the mating, gestation and lactation periods. Parental
toxicity was observed mostly in the high-dose group, in both generations, as increased
incidences of clinical signs (red/brown urine, piloerection, and ulcers on palate and tongue);
increased incidences of ophthalmoscopic signs (eye opacity, partial or total lenticular cataracts,
and iritis); statistically significant (p < 0.01) decreased body weight gains during the
premating (males, 15-40% and females, 10-37%), gestation (20-23%) and lactation (32-80%)
periods; and statistically significant (p< 0.05 or 0.01) decreased food consumption during the
premating (males, 7-40% and females, 5-33%), gestation (8-14%) and lactation (16-28%)
periods. The clinical signs were confirmed by gross and microscopic pathology.
Reproductive toxicity was observed only at the 400/240 ppm level in both generations as
decreased numbers of the live F1 pups/litter on days 1-22 (15-16% fewer than in the control
group; p< 0.05); and as decreased body weight gain, on day 22, of the F1 pups (males, 21%
and females, 18%; p<0.05) and of the F2 pups (13%, males and females; p<0.01), when
compared with the respective controls. Based on the above findings, the NOEL and LOEL
for systemic toxicity are 16 ppm (0.8 mg/kg/day) and 80 ppm (4 mg/kg/day), respectively,
expressed as diquat cation. The NOEL and LOEL for reproductive toxicity are 80 ppm (4
mg/kg/day) and 400/240 ppm (20/12 mg/kg/day), respectively, expressed as diquat cation.
(MRID 41531301)
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g. Mutagenicity
Diquat dibromide was negative for mutagenicity in the following tests: 1 gene
mutation (Ames), 2 structural chromosome aberration (mouse micronucleus and dominant
lethal in mice) and 1 other genotoxic effects (unscheduled DNA synthesis in rat hepatocytes in
vitro). Diquat dibromide was positive in 1 gene mutation test (mouse lymphoma cell assay)
and in 1 chromosome aberration test (human blood lymphocytes, depending on the
concentration of diquat dibromide and the presence or absence of the metabolic activation
system).
Technical diquat dibromide was not mutagenic in the Ames test. In two separate
experiments, diquat dibromide (0.01-100 ug/plate) did not induce any significant increase in
the observed numbers of revertant colonies in any of the five strains of Salmonella
typhimurium (TA1535, TA1537, TA1538, TA98 and TA100) and one strain of Escherichia
coli (WP2uvrA pKM 101) used, with or without the metabolic activation system (rat liver
postmitochondrial fraction, S9, plus cofactors). An appropriate positive control was used with
each strain. This study satisfies guideline requirements for genetic effects Category I, Gene
Mutations. (MRID 40323103)
Technical diquat dibromide was mutagenic in the mouse lymphoma cell assay. It
induced forward mutation in the L5178Y mouse lymphoma cell line as monitored by cell
growth in the presence of trifluorothymidine (TFT), with and without the metabolic activation
system (S9 mix). Positive results were obtained with known mutagens, N-
nitrosodimethylamine (DMN) requiring metabolic activation and ethylmethanesulphonate
(EMS) not requiring activation. Concentration-dependent cytotoxicity was observed at all
levels tested with and without the S9 mix. Mouse lymphoma cells L5178Y were exposed to
diquat dibromide (6.25-100 ug/mL and 3.12-50 ug/mL without and with the S9 mix,
respectively) for 2 hours, centrifuged, washed, and a sample was examined for survival
(cytotoxicity). The remaining cells were maintained in exponential growth for 72 hours and
then were grown in the presence of TFT. Negative (solvent) and positive controls were
treated in the same manner. This study satisfies guideline requirements for genetic effects
Category I, Gene Mutations. (MRID 40323101)
Technical diquat dibromide, at two levels tested, was not clastogenic in the mouse
micronucleus test. Bone marrow was obtained from the C57Bl/6J/Alpk male and female mice
which were treated with single intragastric doses of diquat dibromide. The dose levels used
were 62.5 mg or 100 mg (expressed as diquat cation)/kg of body weight. These levels were
equivalent to 50% and 80%, respectively, of the Median Lethal Dose (MLD; 125 mg/kg)
determined in a preliminary study. Positive results were obtained with cyclophosphamide, a
known clastogen. Diquat dibromide reached the target organ (bone marrow), as indicated by
the cytotoxicity observed at both doses. This study satisfies guideline requirements for genetic
effects Category II, Structural Chromosome Aberrations. (MRID 40323104)
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Another chromosomal aberration study was conducted with human blood lymphocytes
obtained from two donors, Donor 1 (male) and Donor 2 (female). Cell cultures of both
donors were exposed to the concentrations of technical diquat dibromide ranging from 2.58 to
258 ug/mL of growth medium, but the following concentrations were selected for analysis of
the cytogenetic potential of the chemical: 12.9, 64.5 or 129 ug/mL for Donor 1 and 12.9,
25.8 or 129 ug/mL for Donor 2. The concentration of 129 ug/mL, with or without the
metabolic activation system (S9), was the maximum tolerated dose (MTD) for each donor,
based on a preliminary study in which diquat dibromide concentrations ranging from 2.58 to
2580 ug/ml (± S9) were tested. MTD was defined as an in vitro exposure level which
reduces mitosis by 50-80%. Diquat dibromide was not clastogenic at concentrations of 12.9
ug/mL (± S9) and 25.8 ug/mL (+ S9), when the treated cultures were compared with the
negative controls. Other concentrations of diquat dibromide tested induced statistically
significant (p< 0.05 or 0.01) increases in chromosomal damage (4.5-30% above the control
values, depending on the concentration of diquat and the presence or absence of S9). Positive
results were also obtained with known clastogens, mitomycin C and cyclophosphamide. This
study satisfies guideline requirements for genetic effects Category II, Structural Chromosome
Aberrations. (MRID 40323106)
Technical diquat dibromide, administered by gavage to Charles River CD-I male mice for 5
consecutive days, did not produce dominant lethal effects at any of the levels tested. The
levels of diquat used were 0, 0.1, 1.0 or 10 mg/kg, expressed as diquat cation. Positive
controls used were ethylmethanesulphonate (EMS; 100 mg/kg, administered by gavage for 5
consecutive days) or cyclophosphamide (Endoxana; 200 mg/kg given once intraperitoneally
one day before mating). This study satisfies guideline requirements for genetic effects
Category II, Structural Chromosome Aberrations. (MRID 00061636)
Technical diquat dibromide at dose levels of 225, 450 or 900 mg/kg of body weight did
not induce unscheduled DNA synthesis in rat hepatocytes exposed in vitro. Unscheduled DNA
synthesis was induced under the same conditions by 6-p-dimethylaminophenylazo-benzthiazole
(6BT), the positive control, tested at 40 mg/kg of body weight. The selection of dose levels
was governed by the need to evaluate diquat at adequate concentrations and that these levels
should not induce toxicity in the hepatocytes. Although hepatocytes from animals in each
group treated with diquat dibromide showed signs of toxicity, as evidenced by pyknotic and
deeply stained nuclei, sufficient cells of normal morphology were available at each dose level
to be examined for unscheduled DNA synthesis. This study satisfies guideline requirements
for genetic effects Category III, Other Genotoxic Effects. (MRID 40323107)
h. Metabolism
Rats were dosed orally with [14C]-diquat dibromide and their urine and feces were
quantitated for radioactivity at selected time intervals following dose administration. About
90% of the radioactivity was eliminated in feces, indicating that diquat was poorly absorbed
from the gastrointestinal tract. Following a subcutaneous injection of [14C]-diquat to
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circumvent the intestine, nearly all of the labeled material was recovered in the urine within 2
days. (MRID 00055107)
Diquat dibromide was slowly absorbed from the gastrointestinal tract of male and
female rats. Irrespective of the type of dosing (oral or intravenous), diquat did not accumulate
in tissues of rats or mice. Following a single oral dose of [14C]-diquat dibromide (60 mg/kg,
expressed as diquat cation), only 5.5% of the administered radioactivity was excreted in the
urine of rats within 7 days. Following an oral feeding of unlabeled diquat dibromide (250
ppm, expressed as diquat cation) to male and female rats for 2, 4 or 8 weeks, there was no
retention of diquat (as determined colorimetrically) in the brain, liver, lung, stomach, small
and large intestines, muscle and blood, and little retention in the kidneys (0.18, 0.25 and 1.17
ppm during weeks 2, 4 and 8, respectively). Ten minutes after an intravenous injection of
[14C]-diquat dibromide (60 mg/ kg, expressed diquat cation), there were indications (whole
body autoradiography), that diquat concentrated in the cartilaginous tissues, the liver and the
urinary bladder. Most of other tissues also showed the presence of radioactivity, including
small amounts in the brain and spinal cord. After 1 hour, the amounts of radioactivity
declined in most tissues. After 24 hours, radioactivity was detected only in the urinary
bladder, and in the small and large intestines. There was still some radioactivity in the
intestines, but none in the bladder, at 72 hours after dosing. (MRID 00065592)
Rats were dosed with [14C]-diquat dibromide (doses were not specified in the review)
either by stomach tube or by subcutaneous injection and their urine and feces were monitored
at 24-hour intervals for 4 days. Following oral administration of [14C]-diquat, the rats
excreted 6.3% and 89.3% of the administered radioactivity in the urine and feces,
respectively, within 4 days. Most of this radioactivity was excreted during the first 48 hours.
In the urine, most of the excreted radioactivity (5.3%) was unchanged diquat, whereas the
remaining 1% was associated with the following metabolites: diquat monopyridone (0.2%),
diquat dipyridone (0.1%) and unidentified metabolites (0.3). In the feces, 65.5% of the
excreted radioactivity was detected in the sulfuric acid-extractable fraction and 15.7% in the
ammonium sulfate-unextractable fraction. In the sulfuric acid fraction, the radioactivity was
distributed as follows: unchanged diquat (57.1%), diquat monopyridone (4.3%) and
unidentified material (4.1%). The ammonium sulfate fraction was not analyzed for
metabolites. Following subcutaneous administration of [14C]-diquat, 87.1% of the dose was
recovered in the urine during 4 days, but only 4.8% was recovered in the first 24 hours. Most
of this radioactivity (78.8%) was unchanged diquat. The amount of radioactivity recovered in
feces and the percent distribution of monopyridone and dipyridone in urine and feces, after the
subcutaneous dose, was not reported in the available review. (MRID 00065593)
i. Neurotoxicity
In an acute neurotoxicity study, diquat dibromide (technical grade) was administered in
a single gavage dose to 10 male and 10 female Sprague-Dawley rats at doses of 0, 25, 75 or
150 mg/kg, expressed as diquat cation. These rats were assessed for reactions in functional
observational battery (FOB) and motor activity measurements at 6 hours postdosing and on
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days 8 and 15. Evidence for neurotoxicity was observed only during the daily clinical
observations. In the 75 mg/kg group, females had an increased incidence of diarrhea (2/10)
and staining of the nose (3/ 10), compared with the controls (0/10). Females in the 150
mg/kg group also had piloerection (7/10), urinary incontinence (3/10), mouth staining (3/10),
upward curvature of the spine (3/10), tip toe gait (3/10), hunched posture (2/10), subdued
behavior (2/10) and sides pinched in (1/10). One female in the 150 mg/kg group, with all of
the above signs, was sacrificed in extremis on study day 6. Males were less affected than
females. The Agency has concluded that symptoms observed in this study may not be due to
direct neurotoxicity. Based on the clinical signs observed in females, the NOEL and LOEL
for the study are 25 mg/kg/day and 75 mg/kg/day, respectively, expressed as diquat cation.
(MRID 42666801)
In a subchronic neurotoxicity study, diquat dibromide (technical grade) was
administered in the diet to 12 male and 12 female Alpk:APfSD rats for up to 14 weeks, at
dietary levels of 0, 20, 100 or 400 ppm, expressed as diquat cation. These doses were
equivalent to 0, 1.6, 8.0 and 32.4 mg/kg/day (males) and 0, 1.9, 9.5 and 38.5 mg/kg/day
(females), expressed as diquat cation. Of these 12 rats/sex/dose, 5/sex/dose were used for a
neurohistopathological examination at the end of the study. Toxic signs were observed only in
the 400 ppm group, as follows: decreased body weights in males and females (10%;
p<0.01), decreased body weight gains in males (20%; p<0.01) and females (18%; p<0.01),
and high incidence of total cataracts (males, 5/12 and females, 7/12) and posterior opacities of
the lens (males, 8/12 and females, 6/12). In addition, food utilization was decreased in the
400 ppm males, at several intervals (14-17%; p< 0.05 or 0.01) and in the females, at weeks
1-4 (19%; p < 0.05). Based on the evidence of cataracts and decreased body weight gain and
food utilization in males and females, the NOEL and LOEL for systemic toxicity are 100 ppm
(mg/kg/day: 8.0 for males and 9.5 for females) and 400 ppm (mg/kg/day: 32.4 for males
and 38.5 for females), respectively. No evidence of neurotoxicity was observed in the
functional observational battery, motor activity measurement or neurohistopathology. (MRID
42616101)
j. Other Toxicological Considerations
Dermal Absorption Studies - Application of the aqueous solutions of [14C]-diquat
dibromide to the 10 cm2 shaved areas on the rats' backs resulted in the following absorption
after a 24-hour exposure: 2.3, 2.1 or 3.3% for dose levels of 0.05, 0.5 or 5.0 mg diquat
cation/rat, respectively. The unabsorbed diquat was recovered from the application sites.
Based on these findings, the absorption of diquat through an intact skin was very low. Male
Sprague-Dawley rats, 4 per group, were used in this study. (MRID 41238701)
Diquat dibromide is readily soluble in water and it ionizes in aqueous solutions. Such
compounds can be expected to be absorbed very slowly and in small amounts through the skin.
The very low absorption of diquat through an intact skin, observed in the above in vivo study,
was confirmed in the in vitro studies. In these studies, the absorption of [14C]-diquat
dibromide through the human and animal whole skins (dermis and epidermis; 2.54 cm2) was
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studied. In one study, the absorption rate (ug diquat cation/cm2/hr) for the human, rat, rabbit,
mouse and guinea pig skins was 0.058, 0.231, 0.333, 0.431 and 0.455, respectively.
According to these data, all skins studied were very poorly permeable to diquat cation, and
human skin was least permeable. Similar results were obtained in other studies in which only
human and rat skins were used. Human abdominal skins were obtained post mortem from
subjects of varying ages, the majority being 60 years old or older. The animal skins were
obtained postmortem from the dorsal area. (MRID 41247201, 41247202, 41247203 and
41247204)
(1) Reference Dose
The RfD/Peer Review Committee determined the RfD (ADI) to be 0.005 mg/kg/day,
expressed as diquat cation, based on the chronic toxicity study in dogs with a NOEL of 0.5
mg/kg/day, with an uncertainty factor (UF)/safety factor (SF) of 100 (5/12/94). This was
based on unilateral cataracts in females and decreased weight of epididymides and adrenals in
males at 2.5 mg/kg/day. The chronic toxicity study in rats, with a NOEL of 0.58 mg/kg/day,
was identified as a supportive or co-critical study. The uncertainty factor (UF) of 100 was
used in estimating the RfD to account for inter-species extrapolation and intra-species
variability. This RfD (ADI) is consistent with the revised ADI established by the Food and
Agriculture Organization/World Health Organization (FAO/WHO) joint meeting on pesticide
residues (JMPR) in 1993.
2. Exposure Assessment
a. Dietary Exposure
The established tolerances for residues of diquat dibromide in/on raw agricultural
commodities and in animal products are presently expressed in terms of the diquat cation (40
CFR 180.226 (a) and (b)). Tolerance levels of 0.02-0.1 ppm are established for crop
commodities and 0.02 ppm for animal commodities. A food additive tolerance for residues in
potable water is expressed in terms of the diquat cation (40 CFR 185.2500 (a) and (b)), as is a
feed additive tolerance for residues in processed dried potato waste (40 CFR 186.2500). A
food additive tolerance for residues in processed potato (including potato chips) is currently
expressed in terms of diquat per se (40 CFR 185.2500 (c)). Adequate enforcement methods
are available for the determination of diquat dibromide residues in/on plant and in animal
commodities.
Plant Metabolism
The reregistration data requirements for plant metabolism are fulfilled. The qualitative
nature of the residue in plants is adequately understood based on an acceptable potato
metabolism study and a rat bioavailability study. The terminal residue of concern in plants is
diquat per se. The established tolerance expression for residues of diquat dibromide in/on
plant commodities is appropriate and no changes are required.
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The potato metabolism study indicated that no metabolism of diquat occurred in potato
tubers following preharvest application of [14C]diquat as a desiccant to potato stalks and stems.
Soybean and wheat metabolism studies had also been previously submitted but were deemed
marginal because of inadequate characterization and identification of 14C-residues in the
commodities of concern. Attempts to further characterize 14C-residues from these studies were
unsuccessful. In lieu of the requirements for additional crop metabolism studies, the Agency
recommended several options to satisfy reregistration data requirements. The registrant opted
to conduct a bioavailability study. The results of the bioavailability study showed that diquat
plant residues are largely not bioavailable; <^% of the 14C is absorbed as a result of feeding
diquat field residues in/on wheat chaff to rats. The retention of diquat residues in tissues was
negligible (<0.004 ppm diquat equivalents) following dosing at _>_ 25X the maximum human
dietary intake.
Animal Metabolism
The reregistration requirements for animal metabolism are fulfilled. The qualitative
nature of the residue in animals is adequately understood based on acceptable poultry,
ruminant, and fish metabolism studies. The terminal residue of concern in animals is diquat
per se. The established tolerance expression for residues of diquat dibromide in animal
commodities is appropriate and no changes are required.
In the poultry metabolism study, laying hens were dosed with ring-labeled [14C]diquat
at 32 ppm (~36X the maximum dietary burden for poultry) in the diet for 4 consecutive days.
The total radioactive residues (TRR; expressed as diquat equivalents) were < 0.001 ppm in
egg yolks, 0.004 ppm in egg whites, 0.004 ppm in fat, 0.003 ppm in muscle, 0.042-0.058
ppm in kidney, and 0.030-0.045 ppm in liver. The predominant metabolites identified were
diquat per se which accounted for 48% of TRR in liver, and diquat monopyridone which
accounted for 15.1% of TRR in kidney; diquat dipyridone and TOPPS [ 1,2,3,4-tetrahydro-l-
oxo-pyrido(l,2-a)-5-pyrazinium salt] were additional minor (<6.6% of TRR) metabolites
identified in these poultry tissues. The unidentified radioactive residues were presumed to
have been incorporated into cell constituents. The Agency has determined that diquat
monopyridone is not a residue of toxicological concern.
The metabolism of diquat dibromide in ruminants had been extensively investigated.
Ethylene bridge-labeled [14C] diquat dibromide was administered at 5 ppm to a Friesian cow
and two Guernsey cows using a drenching bottle. One of these Guernsey cows was
additionally dosed with ethylene bridge-labeled [14C] diquat dibromide at 20 ppm by the same
method and with bipyridyl-labeled [14C]diquat dibromide at 5 ppm; at least one month was
allowed between repeat dosings. A Guernsey bull calf was also administered ethylene
bridge-labeled [14C]diquat dibromide at 8 ppm. The radioactivity levels in milk were found to
be dose-related, and were not affected by the radiolabel position. The highest TRR value in
milk was 0.077 ppm and was observed in the 72-hour milk sample from the cow dosed at 20
ppm. In milk samples from the high-dose cow, residues of diquat per se were quantitated at
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< 0.002 ppm (determined by colorimetry, limit of detection not provided), and did not
concentrate in the fat, casein or whey. No residues (< 0.01 ppm) were found in the leg
muscle samples from the Friesian cow dosed at 5 ppm. In the bull calf sacrificed 24 hours
after dosing at 8 ppm, the TRR were 1.071 ppm in kidney, 0.033 ppm in liver and < 0.04
ppm in other tissues. Residues of diquat per se were 0.03 ppm and < 0.01 ppm in the kidney
and liver samples, respectively. In addition to the studies briefly summarized above, other
cow and goat metabolism studies had been submitted but were deemed marginally adequate
because the test animals were preconditioned, were not sacrificed within 24 hours of dosing,
or the radioactive residues in tissues were incompletely characterized. Nonetheless, these
ruminant data confirm that the residue of concern in ruminant milk and tissues is diquat per
se.
In the fish metabolism study, trout and carp were exposed to an initial concentration of
1 ppm of bridge-labeled [14C]diquat in the water for 7 days. The TRR (expressed as diquat
equivalents) in carp head and tail, viscera, and body with skin were 0.025-0.077 ppm, 0.135-
0.946 ppm, and 0.013-0.024 ppm, respectively. The TRR in skin and in flesh without skin
were 0.015-0.023 ppm and 0.006-0.016 ppm, respectively. The TRR in trout head, tail, and
flesh were 0.025-0.051 ppm, 0.059-0.239 ppm, and 0.008-0.01 ppm, respectively.
Approximately 65% of the radioactivity in carp flesh and trout viscera was identified as diquat
per se.
Residue Analytical Methods-Plants and Animals
Enforcement methods: The Pesticide Analytical Manual (PAM) Vol. II. lists a
spectrophotometric method, designated as Method A (also referenced as Chevron Chemical
Company RM-8-7) as available for the enforcement of tolerances for residues of diquat per se
in/on plant and in animal commodities. In this method, residues are extracted with sulfuric
acid to free diquat from the bound state, absorbed on cation exchange resin, and eluted with
saturated ammonium chloride. The diquat in the eluate is reduced by sodium dithionate,
forming an intense green color and is measured spectrophotometrically at 337 m//. The limit
of detection is 0.01 ppm.
The registrant has proposed new enforcement methods, RM-5B-1 and RM-5C (replaces
RM-5X-1), for plant and animal commodities, respectively. Both methods involve extraction
of residues by acid hydrolysis, concentration, and cleanup on an ion-exchange column,
reduction with sodium borohydride, selective pH partitioning, and measurement of the diquat
reduction product by gas chromatography using a nitrogen/phosphorus flame ionization
detector. The stated limit of detection is 0.005 ppm for RM-5B-1; the limit of detection for
RM-5C is not clearly specified. Both methods have been adequately validated by the
registrant; however, an independent laboratory validation must be conducted followed by
validation by the Agency's Analytical Chemistry Section before they can be deemed fully
adequate for enforcement purposes. Once a successful Agency method validation has been
performed, these methods will be sent to FDA for inclusion in PAM Vol. II.
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Data collection: Residue data submitted for tolerance reassessment were collected using the
current or proposed enforcement methods. The registrant provided adequate method
validation data to verify the suitability of these methods for data collection.
Multiresidue method: The FDA's PESTDATA dated 11/6/90 (Pam Vol. I, Appendix)
indicates that recovery of diquat dibromide using Multiresidue Protocols is unlikely. The
updated PESTDATA dated 08/93 does not have an entry for diquat dibromide.
Storage Stability
The requirements for storage stability data are fulfilled for purposes of reregistration.
Adequate storage stability data on diquat dibromide are available to support the storage
conditions and intervals of samples from magnitude of the residue studies in plants and
animals. Residues of diquat per se are stable under frozen (-20°C) storage conditions for: (i)
up to six months in/on bell pepper, carrot roots, clover (hay and seed), lettuce, potato, rice
(grain and straw), sorghum grain, soybean, tomato and tomato processed fractions, and wheat
(grain and straw); (ii) up to 8 months in processed fractions of sorghum grain and soybean;
and (iii) up to 2 months in water and seafood samples.
Magnitude of the Residue in Plants
All data for magnitude of the residue in plants have been evaluated and deemed
adequate. All field residue data have been re-evaluated and plant commodity tolerances
reassessed for reregistration purposes.
The registered uses of diquat dibromide on potato for preplant/preemergence or for
preharvest desiccation are supported by acceptable residue field data reflecting maximum label
rates. Sufficient data are available to ascertain that the established tolerance of 0.1 ppm in/on
potato and the feed additive tolerance of 1 ppm for residues in processed potato waste are
adequate. In accordance with Agency evaluation of the available data, a petition to increase
the food additive tolerance of 0.5 ppm for residues in/on processed potato to 1 ppm was
submitted to reflect the higher concentration factor which occurred in processed potatoes from
potato bearing measurable weathered residues in some of the submitted tests. The tolerances
are expressed in terms of potato granules/flakes and potato chips.
The registered uses of diquat dibromide on sorghum and soybean grown for seed as a
preharvest desiccant are supported by adequate field residue data reflecting maximum label
rates. Because there are no established tolerances for residues of diquat in/on sorghum and
soybeans, the registrant has proposed a tolerance on sorghum and has committed to do so for
soybeans. Tolerances of 2.0 ppm and 0.2 ppm appear to be appropriate for sorghum and
soybeans, respectively.
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The registered uses of diquat dibromide on alfalfa and clover grown for seed as a
preharvest desiccant are supported by acceptable field residue data. The available data
indicate that residues did not exceed 2.4 ppm in/on alfalfa seed and 1.7 ppm in/on clover seed
following tests conducted at label rates. The registrant has proposed tolerances of 5.0 ppm for
residues of diquat dibromide in/on both alfalfa and clover seed. The proposed tolerance level
for alfalfa was too high and a new petition for a lower tolerance levels has been submitted. A
tolerance of 3.0 ppm would be more appropriate for alfalfa seeds. Clover seed are no longer
considered to be a significant food or feed item and, therefore, a tolerance is not required.
Furthermore, the registrant must propose a true PHI before which seed may not be harvested,
i.e., a label restriction rather than an efficacious interval. Based on the available data, a 3-day
PHI would be appropriate.
The registered uses of diquat dibromide (i) as a preharvest desiccant on carrot, radish,
and turnip grown for seed, and (ii) as a postharvest desiccant on cantaloupe, cucumber,
pepper, squash, tomato, and watermelon are considered to be non-food uses. No residue data
are required and no tolerances are needed. The raw agricultural commodities associated with
these uses are not likely to be consumed by humans or animals.
Since there are no registered uses of diquat dibromide on sugarcane and vetch, field
residue data for these crops are no longer required. The established tolerance for residues
in/on sugarcane will be revoked.
Magnitude of the Residue in Processed Food/Feed
The data for magnitude of the residue in processed food/feed have been evaluated and
deemed adequate to determine the extent to which residues of diquat concentrate in food/feed
items upon processing of raw agricultural commodities. Acceptable potato, soybean, and
sorghum processing studies have been submitted and evaluated.
The potato processing data indicate that residues of diquat concentrated 5x and 12x in
potato chips and dried potato, respectively. A petition has been submitted to increase the
existing food additive tolerance of 0.5 ppm for residues of diquat in processed potato (which
includes dried potato, granules, and chips) to 1 ppm for potato, granules/flakes and potato
chips. Data depicting residues in dried potato processed from potato bearing measurable
residues may be translated to processed potato waste. The established feed additive tolerance
for residues of diquat in processed potato waste has been reassessed and found to be
appropriate.
The soybean processing data indicate that residues of diquat concentrated 2.6x in
soybean hulls processed from soybean bearing detectable residues. No concentration of
residues was observed in other soybean processed fractions. The registrant has committed to
propose a feed additive tolerance for residues of diquat in soybean hulls; a feed additive
tolerance of 0.6 ppm would be appropriate based on a recommended tolerance of 0.2 ppm for
soybean and a concentration factor of ~3x in soybean hulls.
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The sorghum processing data indicate that residues of diquat concentrated 4x in
sorghum dry milling bran fraction processed from sorghum bearing detectable residues.
According to the revised Table II of Subdivision O's Pesticide Assessment Guidance (PAG),
the only processed commodity entry for sorghum is flour. Residue data are not needed for
flour at this time since sorghum flour is used exclusively in the U.S. as a component of
drywall, and not as either a human or animal feed item. However, because 50% of the
worldwide sorghum production goes toward human consumption, the Agency reserves the
right to require data if needed at a later date.
Magnitude of the Residue in Meat, Milk, Poultry, and Eggs
The reregistration requirements for magnitude of the residue in animals are fulfilled.
There are no registered direct animal treatments for diquat on cattle, goats, hogs, horses,
sheep, or poultry. The residue of concern in animals is diquat per se, and acceptable animal
feeding studies depicting diquat per se have been submitted and evaluated.
The maximum dietary burden for beef and dairy cattle had been calculated previously.
The past dietary burden estimate was based on tolerances of commodities for which tolerances
are no longer established. For reregistration purposes, a new burden estimate, based on
reassessed established/proposed tolerances of feed commodities and revised Table II of
Subdivision O's PAG, is presented below.
Estimate of Maximum Ruminant Dietary Burden for Diquat Dibromide.
Commodity
Alfalfa seed
Potato processed waste
Soybean hulls
Tolerance
(ppm)
3.0a
1.0
0.6b
%Dry
Matter
88
12
90
Total
Beef Cattle
% of Diet
25
75
__
100
Burden (ppm)
0.85
6.25
__
7.10
Dairy Cattle
% of Diet
25
50
25
100
Burden (ppm)
0.85
4.17
0.17
5.19
a Recommended tolerance level for alfalfa seed.b Recommended tolerance level for soybean hulls.
In a cattle feeding study, residues of diquat were non-detectable (< 0.003 ppm) in milk
and tissues following feeding of diquat-treated rye grass silage to cattle at 3.6 ppm (~0.7x and
0.5x the maximum dietary intake for dairy and beef cattle, respectively) for 30 days. In
another study, residues of diquat were non-detectable (< 0.01 ppm) in milk following feeding
of diquat-treated clover hay to cattle at 11 ppm (~2.1x) for 34 days. The established 0.02-
ppm tolerance level for diquat residues in milk is adequate. The established tolerances of 0.02
ppm for diquat residues in the fat, meat, and meat byproducts of cattle, goats, hogs, horses,
and sheep may be raised to 0.05 ppm to achieve compatibility with the Codex maximum
residue limit (MRL).
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The maximum dietary burden for poultry is 0.881 ppm; the calculation of the poultry
burden is presented below. In a poultry feeding study, residues of diquat were mostly non-
detectable (< 0.005 ppm) in samples of eggs, fat, muscle, liver, and skin from chickens fed
diquat at 1, 4.3, and 8.2 ppm diquat cation (~l.lx, 4.9x, and 9.3x, respectively, the estimated
dietary burden) in the diet for 28 days. A single skin sample from the day-21, 8.2 ppm
treatment group bore residues of 0.006 ppm. Residues in gizzard ranged from non-detectable
to 0.022 ppm. The established 0.02-ppm tolerance level for diquat residues in poultry fat,
meat, meat byproducts and eggs may be raised to 0.05 ppm to achieve compatibility with the
Codex maximum residue limit (MRL).
Estimate of Maximum Poultry Dietary Burden for Diquat Dibromide.
Commodity
Alfalfa seed
Soybean hulls
Cereal grain (e.g., corn)
Tolerance
3.0a
0.6b
0.02
Total
% of Diet
25
20
55
100
Burden (ppm)
0.75
0.12
0.011
0.881
a Recommended tolerance level for alfalfa seed.b Recommended tolerance level for soybean hulls.
Magnitude of the Residue in Potable Water
The Agency no longer establishes tolerances for residues in potable water (47 FR
25746, 12/15/82); the tolerance for diquat dibromide has been replaced with a designated
maximum contaminant level goal (MCLG). An MCLG of 0.02 mg/L for residues of diquat in
potable water has been established (57 FR 31776, 7/17/92).
Magnitude of the Residue in Fish and Shellfish
All data requirements for magnitude of the residue in fish and shellfish have been
evaluated and deemed adequate to reassess the tolerances for diquat; no additional data are
required regarding this topic. The available data indicate that residues of diquat in fish and
shellfish will exceed the established tolerances following tests reflecting the current maximum
registered use patterns. The registrant has submitted a petition requesting tolerances of 2.0
ppm for fish and 20 ppm for shellfish to cover all residues of diquat which may occur as a
result of the currently registered uses.
Magnitude of the Residue in Irrigated Crops
The available data concerning diquat residues following irrigation of bean, blackberry,
carrot, corn (sweet), cowpea, pasture grass, peach, rice, and strawberry are adequate to
support the established 0.02 ppm tolerances for diquat residues in/on all members of the crop
groups containing these commodities. However, the data also indicate that residues in/on
mustard greens and tomato may exceed the tolerances for the respective crop groups. A
26
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higher tolerance level of 0.05 ppm for fruiting vegetables and Brassica leafy vegetables has
been proposed by the registrant in accordance with Agency recommendations.
At the Agency's recommendation, the registrant has petitioned to increase tolerances
from 0.02 to 0.1 ppm for residues of diquat in/on the following miscellaneous commodities:
avocado, cottonseed, hops and sugarcane irrigated with water treated with diquat dibromide.
In the absence of adequate supporting data, the Agency translated available data on other
crops. If the registrant desires lower tolerances, data may be submitted specifically for these
miscellaneous commodities.
Confined/Field Rotational Crops
The data requirements for confined rotational crops have been reviewed and deemed
adequate. The requirements for limited and extensive field rotational crop studies have been
waived at this time.
b. Occupational and Residential
Mixers, Loaders, Applicators (Handlers) Exposure
There is an exposure potential for mixers, loaders, applicators, or other handlers
during the ordinary use-patterns associated with diquat. The mixing, loading, and application
methods include open pouring, broadcast (aerial and ground) application and application with
hand-held equipment.
M/L/A Exposure Studies
Requirements for mixer/loader/applicator (i.e., handler) exposure studies are addressed
in Subdivision U of the Pesticide Assessment Guidelines. An assessment of diquat dibromide
dermal and inhalation exposure data was conducted, based on the findings in the Toxicology
Endpoint Selection Document for diquat dibromide.
To assess mixer/loader/applicator (handler) exposure to the adverse effects of diquat,
data provided in the Pesticide Handlers Exposure Database (PHED) were used. The data in
PHED are normalized by pounds of active ingredient handled, and are referred to as unit
exposures. Whenever possible, surrogate unit exposures are chosen from studies having the
same (baseline) PPE required for the active ingredient being evaluated. When label specific
PPE data are not available, existing data points are adjusted using a 50% protection factor
based on the type of PPE. For example hand exposure is reduced by 50 percent, if the
Agency assumes chemical-resistant gloves are worn. The diquat handler assessment assumes
the use of coveralls worn over a long-sleeved shirt and long pants, chemical-resistant gloves
and a respirator as required on product labels.
27
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Based on the use patterns and potential exposures described above, ten exposure
scenarios were identified for diquat. Seven scenarios were identified for large scale
applications: (1) open mixing/loading, (2) closed mixing/loading, (3) applying with a ground-
boom sprayer, (4) applying with a hand-held sprayer, (5) applying aerially, (6) applying to
aquatic sites using direct pouring, and (7) applying to aquatic sites using handguns. Three
scenarios were identified for smaller-scale applications: (1) applying (including mixing and
loading) using backpack equipment, (2) applying (including mixing and loading) using low-
pressure handwand equipment, and (3) applying (including mixing and loading) for spot
treatments at residential sites using small, low-pressure spray equipment.
The exposure scenarios are presented in Table 1, which summarizes the caveats and
parameters specific for each exposure scenario. The actual clothing and equipment worn by
persons being monitored in the exposure studies are described.
In this exposure assessment, the amount of diquat applied and the potential exposure
are estimated based on the cation, not the entire diquat dibromide molecule, with the exception
of the 1983 study by Wojeck, which appears to consider the salt.
These assessments assumed the maximum agricultural use-rate. In non-crop situations,
a higher use-rate is allowed for application on Bermuda grass. However, since these
applications would likely be to golf courses and the typical golf course acreage (45 acres) is
less than is assumed for a typical crop acreage (80 acres), the potential exposure is expected to
be similar.
M/L/A Incidence Data
As of August 18, 1994, the following diquat dibromide poisoning data were available:
A. California Department of Food and Agriculture reported 19
systemic cases of diquat dibromide poisoning during 1982-89.
There were 4 hospitalized cases (1 agricultural poisoning ranked
definite/probable; 2 non-agricultural occupational cases, 1 ranked
definite/probable and 1 ranked possible. These 4 cases required
a total of 40 days of hospitalization. This chemical ranked 9th in
California for days hospitalized.
• Also, for the same time period California reported 19 agricultural cases,
all ranked definite/probable. In addition, there were 8 non-agricultural
cases ranked definite/probable and 3 possible; plus 10 non-agricultural,
non-occupational cases, all ranked definite/probable.
• For 1990, 8 additional systemic diquat dibromide poisoning incidents (5
definite/probable and 3 possible) were reported to the California Illness
28
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Surveillance System. These included 1 systemic poisoning incident, 2
eye and 2 skin, all rated definite/probable.
• According to the draft (8/94) California risk chacterization document for
diquat, "virtually all illnesses reported during agricultural use occurred
as the result of equipment failure, accidental exposure, or violations of
label requirements"
B. Diquat dibromide was not included in the Acute Worker Risk
Strategy, therefore there are no data available from the American
Association of Poison Control Centers.
C. For diquat (only listing), the National Pesticide Telecommunication
Network reports from 1984-1991 inclusive, show 74 human poisoning
incidents and 8 animal poisoning incidents, 15 rated other, and 97 total
incidents among 345 calls to the EPA hotline.
D. The EPA Incident Data System (June, 1992 to July, 1994) contains
reports for two submissions reported under 6 (a) (2), including 1
probable incident for a three year old child who ingested diquat from a
bottle, and 1 wildlife episode (unknown certainty).
Post-Application Exposure
There is an exposure potential for persons entering treated sites after application is
completed. These exposures included persons swimming in diquat treated aquatic sites,
persons (such as maintenance personnel) exposed to treated non-crop sites (golf courses,
rights-of-way, residential sites), and persons (such as crop advisors and harvesters) exposed to
treated crop sites. Seed-crops are harvested 5 to 10 days after application; potatoes are
harvested 7 or more days after application.
Post-Application Exposure Studies
Requirements for post-application exposure studies are addressed by Subdivision K of
the Pesticide Assessment Guidelines. Post-application exposure data submitted to support
reregistration consist of soil and foliar dislodgeable residue studies (MRID 40917401 and
40917402, respectively).
The soil dislodgeable study conducted by the registrant indicates levels of diquat in the
soil after the digger machines have buried the potato tops and exposed the potato tubers at 0.5
ppm (MRID 40917401). Surrogate data were used to estimate human exposure to these
residue levels. To estimate the rate of transfer (soil to hand), the exposure rate per hour was
adjusted from the surrogate study (1 ppm) to the levels of diquat observed in the registrant's
study (0.5 ppm). Thus, a rate of transfer was estimated to be 1.9 jJg/hr or 15.2 jjg/day. By
29
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assuming the weight of the exposed individual was 48 kg, the average daily exposure was
estimated to be 3.2 x 104 mg/kg/day.
The potential for postapplication/reentry exposure for golfers is anticipated to be low,
following applications to golf courses, because the applications to the turf and exposure to
golfers is primarily limited to the shoes from walking over treated surfaces. Exposure to golf-
course maintenance personnel, however, is a concern, because their routine tasks may require
exposure to the treated turf through such activities as bagging/disposing grass clippings and
relocating the flag-holes on the greens.
The potential for post-application/reentry exposure following application as a spot
treatment in residential gardens, driveway edges, and patios is low due to the limited
frequency and duration of exposure. However, potential post-application broadcast
applications at residential sites is expected to be similar to that of golf-course maintenance
personnel.
There is a potential for post-application exposure to swimmers following applications
to aquatic sites such as lakes and ponds. There are no diquat specific exposure data to assess
swimmer exposure. However, an assessment was conducted using information provided in
EPA's Dermal Exposure Assessment: Principles and Applications, Interim Report, January
1992.
To estimate the flux rate for diquat for one hour through skin, the permeability
constant for ethylene dibromide (3.3 x 10 3) was used since this compound is used to produce
diquat, and a permeability constant (Kp) for diquat is not available. The assessment of
swimmer exposure is based on the following:
Fick's Law : dm/dt = Kp * concentration (1.5 x 103)
= 3.3x 103* 1.5x 103
= 4.95 x 106
The body weight of an average six-year old boy is assumed to be 21.9 kg and to have a
surface area of 0.88 square meters. The swimming period is assumed to be 3 hours.
Exposure
Time (hr)
3
Surface
Area
0.88
cm2 x 104
1
dm/dt
(mg/cm2/hr) x 10 6
4.95
Total Dermal
Exposure (mg) 10 2
12.9
Oral absorption will also account for a portion of the exposure. It is assumed that 1% of the
water in residence in the mouth while breathing will be swallowed. Oral exposure is as
follows:
30
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Exposure Time (hr)
3
Contact Rate (1/hr)
.05
Concentration (mg/L)
1.5
Total Oral Exposure (mg)
0.225
Due to diquat's low vapor pressure and the fact that it is a large molecule, exposure via the
inhalation route or penetration through ear wax was not considered.
3. Risk Assessment
a. Dietary Chronic Risk Analysis
This chronic dietary risk analysis is based on the Reference Dose (RfD) for chronic
oral exposure as determined by the Agency's RfD/Peer Review Committee. The diquat
dibromide RfD is 0.005 mg/kg/day. Percent crop treated data were included in this dietary
risk analysis.
The ORES chronic analysis used tolerance level residues to calculate the Theoretical
Maximum Residue Contribution (TMRC) for the overall U.S. population and 22 population
subgroups. Refinements in percent crop treated information were considered in calculating the
Anticipated Residue Contribution (ARC) for the same population groups. The ARC is
considered the more accurate estimate of dietary exposure. These exposure estimates were
then compared to the RfD for diquat dibromide to calculate estimates of chronic dietary risk.
Using Tolerances
The Theoretical Maximum Residue Contribution (TMRC) for the overall U.S.
population from published and proposed uses recommended through reregistration are listed
below:
Subgroup Exposure (mg/kg/day) %Reference Dose
U.S. population 0.002675 54
Children (1-6) 0.004590 92
Non-Nursing
infants < lyr. 0.004519 90
31
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Using Anticipated Residues
The Anticipated Residue Contribution (ARC) for the overall U.S. population from
published and proposed uses recommended through reregistration are listed below:
Subgroup Exposure (mg/kg/day) %Reference Dose
U.S. population 0.001529 31
Children (1-6) 0.002339 47
Non-Nursing
infants < 1 yr. 0.002471 49
The U.S. population and all the subgroups have ARCs for chronic dietary risk below the RfD
when published and proposed tolerances for reregistration are considered. It appears that
chronic dietary risk is minimal for diquat dibromide for published and proposed tolerances.
b. Occupational and Residential
Toxicity Endpoints
Diquat is classified as Toxicity Category II for acute dermal toxicity and primary eye
irritation; Category III for acute oral and acute inhalation toxicity; and Category IV for dermal
irritation.
The short term (1 to 7 days) and intermediate term (1 week to several months)
toxicological endpoints for occupational and residential risk assessment are based on systemic
toxicity resulting from dermal and inhalation exposures. These endpoints were derived from a
21-Day dermal toxicity study in rabbits (MRID 00140576) and a 21-day inhalation study in
rats (MRID 40640801), respectively. For both short and intermediate term occupational/
residential exposures, the systemic NOEL = 20 mg/kg/day and the LOEL = 40 mg/kg/day
for dermal toxicity; the NOEL = 0.1 microgm/1 and LOEL = 0.49 microgm/1 for inhalation
toxicity.
The Agency has previously used two endpoints, one inhalation and one dermal, to
assess both short-term and intermediate occupational and/or residential exposure to diquat
dibromide. The endpoints for dermal exposure and inhalation exposure are:
21-day dermal toxicity study in rabbits (MRID 00140576) - Systemic NOEL = 20
mg/kg/day based on weakness, unsteadiness, and weight loss.
21-day inhalation toxicity in rats (MRID 40640801) - NOEL = 0.1 pig/L, based on
lung lesions. To convert this NOEL to mg/kg/day, the following is assumed:
[0.1 pg/L * 29 1/min * 60 min/hr * 8 hr/day]/70 kg
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Ethylene dibromide (EDB) is used in the manufacture of diquat dibromide and occurs
as an impurity in diquat dibromide products. The possibility for exposure to EDB was
addressed in the 1986 Guidance for the Reregistration of Diquat Dibromide. According to
that document, 10 ppm is the certified maximum EDB level permitted in the formulated
products. The Agency concluded that the presence of EDB as an impurity does not pose
significant risk to human health, either to the public or to applicators.
In this risk assessment for occupational/residential exposure protection factors were
applied to the exposure data to simulate use of the following personal protective equipment
(PPE) for dermal protection: chemical-resistant gloves and coveralls over long-sleeved shirt
and long pants. In addition, a dust/mist filtering respirator was assumed for most mixer,
loader, and application exposure scenarios. A summary of MOEs and exposure scenarios are
provided in Table 1.
Mixers, Loaders, Applicators (Handlers) Risk
In large-scale applications, the highest potential exposure and risks are to mixers and
loaders supporting aerial applications. For mixers and loaders using open systems to support
aerial applications, the dermal MOE is 71 and the inhalation MOE (assuming the use of a
respirator) is 100, where the MOE = NOEL •*• Exposure. For mixers and loaders supporting
aerial applications using closed systems, the dermal MOE is 400 and the inhalation MOE
(assuming no use of a respirator) is 133. These MOE assessments assumed the maximum
agricultural application-rate. In non-crop situations, a higher application-rate is allowed for
use on Bermuda grass. However, since these applications would likely be to golf courses and
the typical golf course acreage (45 acres) is less than is assumed for a typical crop acreage (80
acres), the MOE's should not be lower.
For applicators participating in large-scale applications, the dermal MOE's are greater
than 100.
For mixers, loaders, and applicators participating in small-scale applications (including
spot treatments by homeowners), the MOE's are all greater than 100. For occupational users,
the MOE's are calculated using baseline PPE coveralls worn over a long-sleeved shirt and
long pants, and chemical-resistant gloves. No PPE was assumed for homeowner users. A
summary of MOEs for each exposure scenario is provided below:
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Table 1. DIQUAT DIBROMIDE EXPOSURE SCENARIOS AND MOEsa
Exposure Scenario (Scenario #)
Unit
Dermal
Exposure
b (mg/lb
ai)
Unit
Inhalation
Exposure1"
(ug/lb ai)
Maximum
Label
Application
Ratec
(Ib ai/acre)
Daily
Maximum
Treated"1
(acres)
Daily
Dermal
Dose6
(mg/kg/day)
Dermal
MOEf
Daily
Inhalation
Dose8
(mg/kg/day)
Inhalation MOEh
Mixer/Loader8
Closed Mixing liquids for Aerial Application
(I)
Open Mixing Liquids For Aerial Application
(ID
Open Mixing Liquids For Ground-Boom
Applications (II)
0.02
0.113
0.113
0.06
0.08
w/respirator
0.08
w/respirator
0.50
0.50
0.50
350
350
80
0.05
0.28
0.06
400
71
307
0.00015
0.0002
0.00005
133
100
400
Applicator
Fixed- Wing Aerial Application (III)
Groundboom Application (IV)
High Pressure Handwand Application (V)
Water Hyacinth Control - Handgun
(Wojeck 1983)
Water Hyacinth Control - Driver
(Wojeck 1983)
Hydrilla Control - Applicator
(Wojeck 1983)
Hydrilla Control - Mixer
Wojeck 1983)
0.005
0.01
0.53
2.80
mg/hr
0.60
mg/hr
0.17
mg/hr
0.47
mg/hr
0.04
w/respirator
0.08
w/respirator
0.09
No Data
No Data
No Data
No Data
0.50
0.50
2.0
1.5
1.5
4.0
4.0
350
80
10
5 hr/day
5 hr/day
5 hr/day
5 hr/day
0.013
0.0057
0.15
0.20
0.05
0.012
0.034
1539
3508
132
100
400
1666
588
0.0001
0.000046
0.000026
No Data
No Data
No Data
No Data
200
435
769
--
—
--
—
Mixer/Loader/Applicator
Mixing/Loading and Application With a
Backpack Sprayer (VI)
Mixing/Loading and Application With a Low
Pressure Handwand Sprayer — Residential
Uses (VII)
1.3
103.0
6
w/respirator
31.0
1.0
1.0
2.0
1000 sq. ft.
0.037
0.034
540
588
0.00017
0.00001
117
2000
All application types for diquat dibromide are foliar/broadcast in nature except for a few spot treatments for ornamentals. No banding, in-furrow or soil injection type techniques are noted.
All unit exposure values presented in Table 1 have been "normalized" to reflect the appropriate PPE clothing scenario recommended in this RED.
Values representing the maximum application rate allowable by the label unless specifically noted (i.e., Ib ai/acre). Mixing/loading scenarios were based on the highest potential cumulative chemical use for all application methods included i
number of acres treated for that application technique.
Values representing the maximum area (acres) which would be used in a typical work day to complete treatments for each equipment type/exposure scenario of interest.
Daily Dermal Dose (mg/kg/day) = [(Unit Exposure (mg/lb ai) * Max. Appl. Rate (Ib ai/treatment) * Max. Treated)/70 kg]. For Wojeck et al, Daily Dermal Dose = [(mg/hr * hours expo sure/day)/70 kg.
Dermal MOE values calculated using the following equation: MOE = Dermal NOEL (mg/kg/day)/Daily Dermal Dose (mg/kg/day); 21 day rabbit dermal NOEL = 20.0 mg/kg/day.
Daily Inhalation Dose (mg/kg/day) = [(Unit Exposure (mg/lb ai) * Max. Treated]/70 kg. In some cases respirators have been added, which are noted in the table.
Inhalation MOE values calculated using the following equation: MOE = [NOEL (pg/L) * 29 L/min * 60 min/hr * 8 hr/day]/Daily Inhalation Dose; 21 day rabbit inhalation NOEL = 0.1 pg/L.
34
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Post-Application Risk and REI Entry
Post-application exposure data were submitted to support reregistration and consist of soil and
foliar dislodgeable residue studies (MRID 40917401 and 40917402, respectively).
Golf Course Postapplication Risk
There is a low potential for post-application/reentry exposure following applications to golf
courses because exposure is primarily limited to walking over treated surfaces rather than full
contact that is possible in a residential situation. Full contact with residues based on
dissipation data (24 hours postapplication) submitted by the registrant (MRID 409174-02)
would be as follows:
1.3 US/cm2 * 10,000 cm2/hr * 8 hours =1.5 mg/kg/day
70kg
This would result in an MOE of 13. At day 4 postapplication the MOE would be 105.
Therefore, a four day postapplication reentry interval (4 day REI) is recommended for
workers at golf courses, when worker activities involve substantial physical contact with the
treated turf. This does not apply to activities such as mowing.
Residential Postapplication Risk
The potential for postapplication/reentry exposure, following application as a spot treatment in
residential gardens, driveway edges, and patios, is low due to the expected contact pattern and
duration of exposure. Based on the MOE's calculated for the golf course workers discussed
above, broadcast treatments to residential turf are not recommended.
Aquatic Site Postapplication Risk
There is a potential for postapplication exposure to swimmers, following applications to
aquatic sites such as lakes and ponds. There are no diquat specific exposure data to assess
swimmer exposure risk. However, an assessment was conducted, using information provided
in EPA's Dermal Exposure Assessment: Principles and Applications, Interim Report, January
1992 as indicated above in the exposure assessment section.
Due to diquat's low vapor pressure and the fact that it is a large molecule, exposure via the
inhalation route or penetration through ear wax was not considered. Total swimmer exposure
is estimated to be [0.354 mg/day]/body weight = 0.016 mg/kg/day or an MOE of 1250, for a
21.9 kg 6 year old person.
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Additional Occupational/Residential Exposure Studies
Handler Studies
Additional handler exposure studies are not required at this time.
Post-Application Studies
Additional post-application exposure studies are not required at this time.
C. Environmental Assessment
1. Ecological Toxicity Data
The ecotoxicological data base is adequate to characterize the toxicity of diquat
dibromide to nontarget terrestrial and aquatic organisms when used on terrestrial food, feed
and nonfood sites, and on aquatic nonfood sites.
a. Toxicity to Terrestrial Animals
In order to establish the toxicity to birds, the following tests are required using the
technical grade material: an avian single-dose oral acute study (71-1) on one species
(preferably mallard duck or bobwhite quail); two subacute dietary studies (71-2) on one
species of waterfowl (preferably mallard duck) and on one species of upland game bird
(preferably bobwhite quail); and because of persistence and multiple applications, two avian
reproduction studies (71-4) on mallard duck and bobwhite quail.
Wild mammal testing is required on a case-by-case basis, depending on the results of
the lower tier studies such as acute and subacute testing, intended use pattern, and pertinent
environmental fate characteristics.
A honey bee acute contact LD50 study is required if the proposed use will result in
honey bee exposure.
(1) Birds, Acute and Subacute
Effects on Non-target Birds
Nine studies were evaluated under this topic. The activity of diquat dibromide
herbicide is expressed in units of cations. In the tables below, the cation will be used for risk
assessment purposes for birds since the use information is in Ib cation per acres in the
terrestrial environment. The cation value in ppm is extrapolated from the test values whether
it be in diquat formulation or cation, or active ingredient. The acceptable toxicity studies for
use in a hazard assessment are listed below:
36
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Avian Acute Toxicity
Avian Acute Oral Toxicity Findings
Species
Mallard
Mallard
% Test Material (TGAI)
45.6
30.0
LD50 in mg/kg cation
per kg
60.6 mg/kg
89.6 mg/kg
Conclusions
Moderately toxic
For hazard assessment, these data indicate that diquat dibromide is moderately toxic in
acute studies to birds. Typically, toxicity testing is to be done with technical grade active
ingredients, usually having relatively high per cent purity. In the case of diquat dibromide, a
test material containing 35 to 37 percent represents, apparently, the highest purity produced.
The guideline requirement for the avian acute oral LD50 study is fulfilled. (MRID 00106559)
Avian Subacute Dietary Toxicity
Avian Subacute Dietary Toxicity Findings
Species
Bobwhite quail
Mallard
Japanese quail
Ring-neck pheasant
Bobwhite quail
%Test
Material
37.0
37.0
37.0
37.0
35.3
LC50
cation per kg
575 ppm
980* ppm
264 ppm
734 ppm
106 ppm
Conclusions
Slightly to moderately toxic
* 30 percent mortality at 980 ppm cation.
On a subacute dietary basis, diquat dibromide ranges from slightly to moderately toxic
to birds. The guideline requirement for the avian subacute dietary study is fulfilled. (MRID
00034769, and 00116565)
Avian Reproduction
Avian reproduction studies are required when birds may be exposed repeatedly or
continuously through persistence, bioaccumulation, or multiple applications, or if mammalian
reproduction tests indicate reproductive hazard. Present product labeling of diquat dibromide
allows several applications of the end-use product per growing season.
Avian Reproduction Findings
Species
Bobwhite
Quail
Mallard
Duck
%
A.I.
35.3
35.3
Reproductive Impairment
None
Number of eggs laid, hatching
and 14-day old survival
Conclusions (ppm cations)
NOEL > 19.6
NOEL = 5
LOEL = 25
37
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The avian reproductive study found the NOEL to be 5 ppm cation and LOEL to be 25
ppm cation. These findings were based on number of eggs laid, hatching and 14-day old
survival. (MRIDs 00119988, 00114230)
(2)
Insects
The minimum data required to establish the acute toxicity to honey bees is an acute
contact LD50 study with the technical material.
Nontarget Insect Acute Contact Toxicity Findings
Species
Honey bee
Honey bee
%Test
Material
99.6
LD50
100 Mg/bee
47 //g/bee*
Conclusion
practically non-toxic to bees
* This was tested as "Reglone" with an LD50 = 171 /^g/bee and as "Reglone + Agral" with an LD50 =66 /^g/bee for acute contact toxicity. This
was also tested for oral acute with "Reglone" (LD50 = 47/^g/bee) and "Reglone + Agral" ((LD50 =35 /^g/bee). Agral is a liquid non-ionic
wetting and spreading agent.
There is sufficient information to characterize diquat dibromide as practically nontoxic
to bees. The guideline requirement is fulfilled. (MRIDs 072012, 40208001)
b. Toxicity to Aquatic Animals
(1) Freshwater Fish
In order to establish the toxicity to fish, the following tests are required using the
technical grade material: two 96-hour acute fish studies (72-1); one on a species of coldwater
fish (preferably rainbow trout) and one on a species of warmwater fish (preferably bluegill
sunfish); and because of persistence one fish early life stage study.
38
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In the table below, the diquat cation will be used for risk assessment purposes for
aquatic organisms since the availability of diquat dibromide is as a cation in aquatic
environments. The value in ppm cation is extrapolated from the test values whether it be in
diquat formulation, cation, or active ingredient. The acceptable toxicity studies for use in a
hazard assessment are listed below:
Freshwater Fish Acute Toxicity Findings
Species
Brown trout
Bluegill
Rainbow trout
Bluegill
Rainbow trout
Bluegill
Yellow Perch
Black Bullhead
% Test Material
(TGAI)
35.3
35.3
35.3*
35.3
35.3
35.3
35.3
35.3
LC50 in ppm
cations
17.8
12.1**
14.8
13.9
>18.7
21.5
4.4
4.6
Conclusions
slightly to moderately toxic
* The study cites the percentage formulation as 19.8 percent cation and having 2 Ib cation per gallon. According to the LUIS report, the 2 Ib cation
per gallon is similar to the 35.3 percent ai formulation (diquat dibromide is made up of about 53 percent cation).
** Results based on 72 hour test rather than 96 hour test.
The results of the acute toxicity studies indicate that diquat dibromide is slightly to
moderately toxic to both cold and warm water fish. The guideline requirement for acute
toxicity testing of the technical on freshwater fish is Milled. (MRID 00115858, 0027203,
00115572, 00138961, and 00003503)
Fish Early Life Stage Study
The MATC below is derived from the geometric mean of the fish early life cycle study which
resulted in a NOEL of 0.58 ppm and LOEL of 1.5 ppm of the test material. The effects at the
1.5 ppm level were reduction in wet weight and length of the larvae. Note that the NOEL and
LOEL are in ppm of test material, which was a 41.4% ai formulation. Furthermore, the
active ingredient is comprised of an active and inactive cation, with only 50.9% active cation.
The NOEL and LOEL, expressed in ppm active cation, would be 0.122 ppm and 0.316 ppm
respectively. Since exposure values for risk assessment are calculated in units of active cation,
the MATC (reported below) will also be reported in units (ppm) of active cation.
Fish Early Life Stage Findings
Species
Channel Catfish
Fathead Minnow
%Test
Material
(TGAI)
unknown
41.4
MATC
in ppm
cations
>1.0
0.197
Conclusions
NOEL = 0.122 ppm cation
LOEL = 1.316 ppm cation
For hazard assessment, these data indicate that diquat dibromide ranges in toxicity to
fish from slightly to moderately toxic. Data requirements for freshwater fish are fulfilled.
39
-------
Typically, toxicity testing is to be done with technical grade active ingredients, usually having
relatively high percent purity. In the case of diquat dibromide, a test material containing 35 to
37 percent represents the highest purity obtainable. (MRIDs 090862, 40380703)
(2)
Freshwater Invertebrates
In order to establish the toxicity to aquatic invertebrates, a 48-hour aquatic invertebrate
acute toxicity test is required using the technical grade material on first instar Daphnia magna
or early instar amphipods, stoneflies or mayflies; and because of persistence one aquatic
invertebrate life cycle study.
Seven studies were evaluated under this topic. In the table below, the diquat cation
will be used for risk assessment purposes for aquatic organisms since the availability of diquat
dibromide is as a cation in aquatic environments. The value in ppm cation is extrapolated
from the test values whether it be in diquat formulation, cation, or active ingredient. The
acceptable toxicity studies for use in a hazard assessment are listed below:
Freshwater Invertebrate Toxicity Findings
Species
Daphnia magna*
Daphnia magna*
Daphnia magna*
Gammarus fasciatus*
Hyalella*
Apple Snail*
Daphnia magna**
%Test
Material
(TGAI)
46.6
46.6
35.2
35.3
unknown
35.3
41.4
EC50 or MATC
ppm cation
EC50= 1.03
EC50= 1.19
EC50= 0.77
EC50= 18.7
EC50= 0.14
EC50= 0.34
MATC = 0.044
Conclusions
Slightly to highly toxic
Acute toxicity Study
Life Cycle Study
There is sufficient information to characterize diquat dibromide as slightly to highly
toxic to aquatic invertebrates. The guideline requirement is fulfilled. (MRIDs 235179,
00115576, 00003530, and 00115862)
(3)
Estuarine and Marine Animals
Acute toxicity testing with estuarine and marine organisms is required when an end-use
product is intended for direct application to the marine/estuarine environment or is expected
to reach this environment in significant concentrations. The terrestrial nonfood use of diquat
dibromide may result in exposure to the estuarine environment.
In order to establish the toxicity to estuarine and marine organisms, the following tests
are required using the technical grade material: either a Mollusc 48-hour embryo larvae study
using Pacific oyster, Eastern oyster, mussel (preferably Mytilus edulis) or Quahog
40
-------
(Mercenaria) or a Mollusc 96-hour Flow-Through Shell Deposition study using Pacific oyster
or Eastern oyster; and a Shrimp 96-hour acute toxicity test using white, pink, brown, grass or
mysid shrimp species; an estuarine fish (preferably silverside or sheepshead minnow).
Four studies were evaluated under this topic. In the table below, the diquat cation will
be used for risk assessment purposes for aquatic organisms since the availability of diquat
dibromide is as a cation in aquatic environments. The value in ppm cation is extrapolated
from the test values whether it be in diquat formulation, cation, or active ingredient. The
acceptable toxicity studies for use in a hazard assessment are listed below:
Estuarine/Marine Acute Toxicity Findings
Species
Mysid Shrimp
Eastern Oyster
Sheepshead Minnow
Striped Bass
% Test Material
(TGAI)
41.1
41.4
41.4
35.3
LC50 ppm
cation
0.42
54.8
48
43.2
Conclusions
slightly to highly toxic
There is sufficient information to characterize diquat dibromide as slightly to highly
toxic to estuarine species. The guideline requirement is fulfilled. (MRID 40315701,
40316001, 40316101, 090862, and 00028002)
c. Toxicity to Plants
Terrestrial plant testing (seed germination, seedling emergence and vegetative vigor) is
required for herbicides which have terrestrial nonfood/feed or aquatic nonfood (except
residential) use patterns and which have endangered or threatened plant species associated with
the site of application.
(1) Aquatic Plants
Aquatic plant testing is required for any herbicide applied to terrestrial nonfood or
aquatic nonfood sites (except residential). In order to establish the toxicity to aquatic plants,
an aquatic plant growth study (123-2) comprising of Selenastrum capricornutum, Lemna
gibba, Skeletonema costatum, Anabaena flos-aquae, and a freshwater diatom is required
using the technical grade material. The registrant has submitted a Selenastrum capricorutum
study.
Two aquatic plant studies were evaluated under this topic. In the table below, the
diquat cation will be used for risk assessment purposes for plants since the availability and
activity of diquat dibromide is as a cation with plants. The value in ppb cation is extrapolated
from the test values whether it be in diquat formulation, cation, or active ingredient. The
acceptable toxicity studies for use in a hazard assessment are listed below:
41
-------
Nontarget Aquatic Plant Toxicity Findings
Species
Tier I, several species of
filamentous algae and
aquatic vegetation
Tier II vascular plants:
Giant Duckweed
Water Hyancinth
Azolla
Hydrilla
% A.I.
35.3
Toxicity
Controlled by 0.25
cation ppm of diquat
FC *
J-^so
0.0036
0.0198
0.0277
N/A
pp **
J-^so
0.75
114.0
11.6
9.9
Conclusions
information insufficient to assess the
toxicity, but sufficient to require Tier II
testing
Vascular plant requirements (Lemna
gibba) are satisfied, but Skeletonema
costatum, Anabaena flos-aquae,
Selenastrum capricomutum, and a
freshwater diatom needs to be tested to
satisfy the requirements under 123-2
and to provide a complete risk
assessment of diquat to non-target
aquatic plants.
* Foliar applied, Ib cation/A
** Rootzone, ppb cation
(MRID 40165103, 40165104, 40165105, and 41883002)
(2)
Terrestrial Plants
Three terrestrial plant studies were evaluated under this topic. In order to establish the
toxicity to terrestrial plants, a germination, seedling emergence (123-la) and vegetative vigor
study (123-lb) is required. The acceptable toxicity studies for use in a hazard assessment are
listed below:
Nontarget Terrestrial Plant Toxicity Findings
Test and Species
Seedling emergence &
Germination (10 species)
Vegetative Vigor (corn,
sweet corn, & wheat)
Vegetative Vigor,
Sensitive species:
Cotton
Soybean
Corn
%A.I.
—
35.3
EC25
>7.49 Ibs ai/Acre
rates as low as 0.016 Ib
cation/A resulted in
desiccation of certain
plants
0.00470 cation Ib/A
0.00738 cation Ib/A
0.01064 cation Ib/A
Conclusions
No effect to plants at 8.4 ai kg/ha
or7.491bai/A*
Tier II vegetative vigor testing
needed
Untreated seeds of wheat and sweet
corn should be tested for tier II
Vegetative Vigor.**
* Tier II seed emergence and seed germination studies do not need to be done.
** Only one grass species was tested. According to earlier study (40165102), sweet corn and wheat were found to be sensitive. Two more grass
species should be tested to fulfill guidelines. If there are difficulties in finding untreated seeds of sweet corn or wheat, the treated seeds could be
washed in methanol to remove most of the treatment and then tested after drying.
There are outstanding data requirements for terrestrial plants. (MRID 40165101,
40165102, and 41883001)
42
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2. Environmental Fate
There is sufficient data for comprehensive qualitative and quantitative environmental
fate, ground and surface water assessments for diquat dibromide.
a. Environmental Fate Assessment
The primary route of environmental dissipation of diquat is strong adsorption to soil
particles. Diquat does not hydrolyse or photodegrade and is resistant to microbial degradation
under aerobic and anaerobic conditions. There were no major degradates isolated from any of
the environmental fate studies. When used as an aquatic herbicide, diquat is removed from the
water column by adsorption to soil sediments, aquatic vegetation, and organic matter.
Adsorbed diquat is persistent and immobile, and is not expected to be a ground-water
contaminant.
The environmental fate data base for diquat is complete for reregistration of diquat
dibromide.
Pesticide Runoff Simulation Modeling:
An estimate of diquat runoff and its effect on surface water quality was evaluated using
PRZM-EXAM models from a typical crop use on potatoes with data from a silt loam soil in
Maine.
Model simulations indicate that a 10 percent exceedance probability of the maximum of
0.33 kg/ha/year diquat could potentially be found in surface water systems. This estimate is a
high exposure scenario of the entire yearly application of 0.5 Ib ai/A to soil on a highly eroded
soil for 36 years. This assessment includes diquat adsorbed onto eroded soil particles as well
as diquat in the runoff water. Estimated environmental concentrations (EEC's) at 10 percent
exceedance probabilities in a one hectare water body, 2 meters deep, are shown in the table
below.
Annual Average EEC of Dissolved Diquat in Maine with 10 percent Exceedance Probability.
Maximum
48.4 ppb
96 hour
47.8 ppb
21 day
45.1 ppb
60 day
45.3 ppb
90 day
43.6 ppb
While these predictions are higher than expected from the environmental assessment of
diquat, the PRZM-EXAM model is predicting a high exposure scenario for diquat applied to
potatoes.
43
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b. Surface Water Assessment
Diquat dibromide is persistent and binds nearly irreversibly to soil. It does not appear
to be biologically available to aquatic organisms in surface water. Therefore, the Agency does
not require a surface water advisory.
c. Environmental Fate and Transport
Hydrolysis
Diquat dibromide was stable to hydrolysis in water at all pHs (tested at pH 5,7, and
9). (MRIDs 154100 and 154101)
Photodegradation in water
Diquat can be considered to be photolytically stable in the environment; diquat
degraded with a calculated half-life of 74 days of Florida spring sunlight. Radiolabeled diquat
in pH 7 buffer was continuously irradiated with a xenon lamp for a period of time that
approximated 32 days of Florida spring sunlight. One degradate, 1,2,3,4-tetrahydro-l-
oxopyrido (l,2-a)pyrazin-5-ium ion, comprised 12 percent of the radioactivity at the
conclusion of the study. (MRID 40418801)
Photodegradation on soil
[14C] Diquat did not photodegrade on loam soil irradiated with a xenon arc lamp at
20.5-29.1°C for 107.42 hours (equivalent to approximately 32 days of natural sunlight).
Diquat was the only compound identified in the extracts. (MRID 40246101)
Aerobic soil metabolism
Diquat at approximately 3 ug/g did not degrade in an aerobic sandy loam soil incubated
at 25°C in the dark for 9 months. (MRID 40972301)
Anaerobic aquatic metabolism
[14C] Diquat did not degrade when incubated under anaerobic aquatic conditions for 9
months at 25°C. After 9 months, one unidentified degradate comprised approximately 5
percent of the applied radioactivity. Throughout the study 89 to 100 percent of the diquat
residues were associated with the soil sediment portion of the system. No anaerobic aquatic
half-life could be calculated. (MRID 40972302)
44
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Aerobic aquatic metabolism
[14C]Diquat did not degrade when incubated under aerobic aquatic conditions for 31
days at 25°C. Between 95 to 99 percent of the diquat residues were associated with the soil
sediment portion of the system. No aerobic aquatic half-life could be calculated. (MRID
40927601)
Mobility — adsorption/desorption
Diquat is immobile with Freundlich Kads values of 15 in sand sediment, 36-42 in two
sand soils, and Freundlich Kads values of 1882-10740 in sandy loam, sandy clay loam, and
loam soils. (MRID 40348601)
Laboratory volatility
Diquat has a vapor pressure of < 4 x 109 mm Hg at 25°C; therefore, volatility is not
expected to be a route of dissipation. There was no evidence of volatility in any study
submitted to satisfy environmental fate requirements. (MRID 40245101)
Dissipation — Terrestrial field and Long-term field
Diquat did not degrade for 3 years after application to two plots in New York;
concentrations of diquat ion ranged from 0.01 to 0.32 ppm in the upper 15-cm soil depth.
The two plots were planted to potatoes; the potato vegetation from the clay loam soil plot was
removed prior to application to represent bare ground application, the other plot was on a
loam soil and diquat was sprayed on the vegetation. There were two applications of diquat
dibromide (2 Ib ai/gal SC/L) at 0.25 Ib diquat ion/A/application (total 0.5 Ib ai/A). In
general, there was no pattern of leaching; diquat was recovered at 0.01-0.03 ppm from
individual soil cores from the 15- to 22.5-cm soil depth.
Diquat did not degrade for 3 years after application to two plots of loam soil in Idaho;
concentrations of diquat ion ranged from 0.01 to 0.13 ppm in the upper 35-cm soil depth.
Application was made to bare ground and to potato vegetation. The plots were cultivated to
35 cm and in subsequent years cropped to a rotation of sugarbeets, wheat and potatoes. There
were two applications of diquat dibromide (2 Ib ai/gal SC/L) at 0.25 Ib diquat
ion/A/application (total 0.5 Ib ai/A). There were no residues recovered from below 35 cm.
(MRIDs 42060301, 42060302, 40335201)
(1) Field Dissipation
Aquatic and Aquatic Impact
Diquat dissipated with half-lives of 1-2 days from Florida pondwater that was treated
four times at 4 Ib ai/A/application at approximately monthly intervals with diquat dibromide
45
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(Ortho Diquat Herbicide-HA). Diquat was removed from the water column by adsorbing to
sediment. The diquat concentrations in the sediment were variable ranging to a maximum of
1.2 ppm in the 0- to 5-cm depth with no discernible pattern of decline. In the aquatic
dissipation study, the sites chosen were both near Gainesville, FL. Although the pond sites
were treated under the same climatic conditions, the sediments were of different textures; one
was sandy clay loam and the other was a sand sediment. The findings from these two sites
were in agreement with findings from field dissipation studies conducted under a variety of
climatic conditions and also were comparable to predictions from laboratory results. (MRID
40917403)
(2) Accumulation
Laboratory Accumulation - Fish
Diquat residues did not significantly accumulate in bluegill sunfish exposed to
[14C] diquat dibromide at approximately 1030 ppb diquat ion for 14 days under flow-through
conditions. The maximum mean bioconcentration factors were 0.7X for edible tissues
(muscle, skin, skeleton), 2.5X for nonedible tissues (viscera) and 1.03X for whole fish.
Depuration was rapid, with approximately 50 percent of the accumulated [14C]residues
eliminated from the fish tissues by day 3 of the depuration period. (MRID 40326901)
Laboratory Accumulation - Non-target organisms
a. Daphnia magna. Diquat residues did not significantly accumulate in Daphnia
magna exposed to diquat dibromide at 10 ug/L in a laboratory flow-through system.
The reported maximum bioconcentration factor was 8.3X, at 1 day post-exposure.
b. Mayfly nymph Diquat residues did not significantly accumulate in mayfly nymphs
exposed to diquat dibromide at 1 mg/L in a laboratory flow-through system. The
reported maximum bioconcentration factor was 32X, at 1 day post-exposure.
c. Oysters Diquat residues did not significantly accumulate in the soft tissue of
Pacific oysters which were exposed to diquat dibromide monohydrate at 0.1 mg/L in a
laboratory flow-through system for up to 28 days. The soft tissue bioconcentration
factor for organisms exposed for 14 days was 5.5X; for those exposed for 28 days, the
soft tissue bioconcentration factor was 10.5X.
Field Accumulation - Fish
Diquat did not significantly accumulate in tissues of tilapia and catfish from two
fish ponds in Florida which were treated with diquat dibromide in four monthly
applications at 4 Ib diquat ion/A/application (total 16 Ib diquat ion/A). Each
application was equivalent to 0.36 ug diquat ion/mL. In tilapia, maximum
concentrations of diquat ion were 8.5 and 0.30 ppm in nonedible (head, tail, and
46
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viscera) and edible (fillet plus skin) tissues, respectively. In catfish, the maximum
concentrations of diquat ion were 0.06 and 0.15 ppm in edible (fillet) and nonedible
(head, skin, tail, and viscera) tissues, respectively. Diquat ion concentrations in fish
tissues did not increase with repeated applications. Diquat ion dissipated from the pond
water with half-lives of 0.72-2.3 days. (MRIDs 40326903, 40326902, 40326904,
40380701)
(3) Spray Drift
Spray drift data are required by 40 CFR § 158.142 when aerial application
and/or mist blower or other ground application are proposed and it is expected that the
detrimental effect level of nontarget organisms expected to be present are exceeded.
3. Exposure and Risk Characterization
a. Ecological Exposure and Risk Characterization
Explanation of the Risk Quotient (RQ) and the Level of Concern (LOG): The
Levels of Concern are criteria used to indicate potential risk to nontarget organisms. The
criteria indicate that a chemical, when used as directed, has the potential to cause undesirable
effects on nontarget organisms. There are two general categories of LOG (acute and chronic)
for each of the four nontarget faunal groups and one category (acute) for each of two
nontarget floral groups. In order to determine if an LOG has been exceeded, a risk quotient
must be derived and compared to the LOC's. A risk quotient is calculated by dividing an
appropriate exposure estimate, e.g. the estimated environmental concentration, (EEC) by an
appropriate toxicity test effect level, e.g. the LC50. The acute effect levels typically are:
-EC25 (terrestrial plants),
-EC50 (aquatic plants and invertebrates),
-LC50 (fish and birds), and
-LD50 (birds and mammals)
The chronic test results are the:
-NOEL (sometimes referred to as the NOEC) for avian and mammal
reproduction studies, and either the NOEL for chronic aquatic studies, or the
Maximum Allowable Toxicant Concentration (MATC), the geometric mean of
the NOEL and the LOEL (sometimes referred to as the LOEC) for chronic
aquatic studies.
When the risk quotient exceeds the LOG for a particular category, risk to that
particular category is presumed to exist. Risk presumptions are presented along
with the corresponding LOC's.
47
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Levels of Concern (LOG) and associated Risk Presumption
Mammals, Birds
IF THE LOG
acute RQ> 0.5
acute RQ> 0.2
acute RQ> 0.1
chronic RQ > 1
Fish, Aquatic invertebrates
IF THE LOG
acute RQ> 0.5
acute RQ> 0.1
acute RQ > 0.05
chronic RQ > 1
Plants
IF THE LOG
RQ> 1
RQ> 1
PRESUMPTION
High acute risk
Risk that may be mitigated through
restricted use
Endangered species may be affected
acutely
Chronic risk, endangered species
may be affected chronically,
PRESUMPTION
High acute risk
Risk that may be mitigated through
restricted use
Endangered species may be affected
acutely
Chronic risk, endangered species
may be affected chronically
PRESUMPTION
High risk
Endangered plants may be affected
Currently, no separate criteria for restricted use or chronic effects for plants
exist.
Established Levels of Concern (LOC's)
Endpoint/Scenario
Mammalian acute
Mammalian chronic
Avian acute
Avian chronic
Aquatic acute
Aquatic chronic
Non-target insects
Non-target plants
Risk Quotient
EEC/LC50
EEC/LEL*
EEC/LC50
EEC/LEL
EEC/LC50
EEC/LEL
NOT QUANTIFIED
EEC/EC25 or EC50
Non-Endangered LOG
0.5
1.0
0.5
1.0
0.5
1.0
N/A
1.0
Endangered LOG
0.1
1.0
0.1
1.0
0.05
1.0
N/A
1.0
Lowest Effect Level. The LEL is
the mammalian and avian chronic
a theoretical level which is a value somewhere between the NOEL and the LOEL. The Agency uses the NOEL to calculate the risk quotients for
risks and the MATC to calculate the risk quotients for the aquatic chronic risk.
48
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(1) Exposure and Risk to Nontarget Terrestrial Animals
(a) Birds
Residues found on dietary food items following diquat dibromide application may be
compared to LC50 values to predict hazard. The maximum concentration of residues of diquat
dibromide which may be expected to occur on selected avian or mammalian dietary food items
following a single foliar application at different application rates is provided in the table
below:
_________________JiiaMM££JMLAylaJCLJUi
^^^^^
Range Grasses
-^hor,iL^^———
Fruit/Vegetable
Leaves (other than
—J^mm£sl__^^
Forage Legumes
—jml^MlL^
-—^£d^lar£eJas^^_
Long Grass
1
!££!______,
Maximum
residue
Typical
residue
Maximum
residue
Typical
residue
Maximum
residue
Typical
residue
Maximum
residue
Typical
residue
Maximum
residue
Typical
residue
(dJdaiffllMllMILEJffiJS^
_______A2^^
0.25a
60
31
31
9
15
8
3
1
28
23
0.375b
90
47
47
13
22
12
5
1
90
47
0.5C
120
63
63
18
29
17
6
1.5
120
63
0.8923d
214
112
111
31
52
29
11
2.7
214
112
Cantaloupe
Cucumber and tomato
Alfalfa, carrot, clover, pepper,
Turf, golf courses, ornamental
squash, potato, radish, turnip, soybean, and sorghum
uses
49
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Acute Risks
Regarding acute avian dietary risks, the table below indicates the risk quotients for
each of the following application rates:
(Dietary RQ =
Use Sites
__EausslshaitLsrjasse& J
— SamlUnsects I.
Leafy crops
Acute Avian Dietary Risk Quotients
iE£jMaxmumjeadu£^aliielZLCiJi^a_s_52ijiKni_aiALh2hfflMtejiuaii
Application Rates in Ibs. A.I. /A
0.25a
0.10
0.03
0.05
0.375b
0.16
0.04
0.08
0.5C
0.21
0.05
0.11
0.8923d
0.37
0.09
NA
Cantaloupe
Cucumber and tomato
Alfalfa, carrot, clover, pepper, squash, potato, radish, turnip, soybean, and sorghum
Turf, golf courses, ornamental uses
High acute risk to birds is not expected from the use of diquat dibromide. However,
level of concern for restricted use has been exceeded (LOG = 0.2) primarily for the turf use.
The LOG for endangered bird species (LOG = 0.1) has been exceeded for those avian species
feeding on short grass, primarily the turf use.
Chronic Risks
The risk quotients for chronic risk to birds were based on both maximum and typical
residues expected to occur immediately after treatment. Diquat is extremely persistent, but
neither the rate of decline on food items, nor rate at which diquat becomes biologically
unavailable to birds is known.
Based on available data, there is moderate to high certainty that some reproductive
effects will occur to birds. The likelihood that this impact will occur frequently, or be of
ecological significance is less certain.
50
-------
Regarding chronic avian risks, the table below indicates the risk quotients for each of
the following application rates:
Chronic Avian Risk Quotients
(Chronic RQ = EEC (Maximum or typical residue value)/NOEL (5 ppm cation)
NOEL = 5 ppm cation from the mallard reproduction study
Use SitesO
Range (short) grasses
Small insects
Leafy crops
Maximum
Typical
Maximum
Typical
Maximum
Typical
Application Rates in Ibs. A.I. /A
0.25a
12
6.3
3
1.7
6.3
4.6
0.375b
18
9.5
4
2.4
9.5
6.9
0.5C
24
12.6
5.9
3.3
12.5
9.1
0.8923d
42.8
22.3
10
5.9
NA
NA
aCantaloupe
'Cucumber and tomato
cAlfalfa, carrot, clover, pepper, squash, potato, radish, turnip, soybean, and sorghum
dTurf, golf courses, ornamental uses
A NOEL of 5 ppm cation and LOEL of 25 ppm cation was determined from the
mallard reproduction study. These findings were based on the number of eggs laid, hatching
and 14-day old survival. The level of concern for chronic risk to avian species has been
exceeded (LOG = 1). Therefore, birds feeding on diquat dibromide contaminated food items
may experience reproductive problems. It is recognized that in some field crops such as
alfalfa, clover and soybean, there may be few short grasses, so residues on leafy crops and
insects may be more representative of actual exposure.
(b) Mammals
Small mammal exposure is estimated using the rat acute oral LD50 values converted to
a LC50 value for dietary exposure. The estimated LC50 = LE)50 X body weight (g)
food. cons, per day (g)
Small Mammal Food Consumption in PPMs
(Based on an LD50 = 600 mg/kg)a
Small Mammal
Herbivore
Insectivore
Body Weight in
Grams
26gms
5 gms
% of Weight Eaten
Per Day
16%
110%
Food Consumed Per
Day in Grams
4.3 gms
5.5 gms
Estimated LC50 Per
Day in PPMs
701 ppm cation
105 ppm cation
The above table is based on information contained in Principles of Mammology by D. E. Davis and
F. Golly, published by Reinhold Corporation, 1963.
a An LD50 in mg diquat dibromide cation/kg was calculated to be 116. This takes into account that
this formulation was 19.3% cationic. Calculation: 600 mg/kg X 0.193 = 116 mg cation/kg.
51
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Discussion of Overall Risk to Mammals:
Diquat dibromide will pose only a low risk to mammals considering the use patterns,
environmental fate characteristics and toxicity. Effects, if they occur should not result in
significant ecological damage.
Acute Risks
Regarding acute mammalian dietary risks, the table below
indicates the risk quotients for each of the following application rates:
Acute Mammalian Dietary Risk Quotients
(Dietary RQ = EEC (Maximum residue value)/Lowest 1-day LC50)
Small Mammal
Herbivore consuming range (short) grasses
Insectivores consuming small insects
Herbivores consuming leafy crops
Application Rates in Ibs. Cation/A
0.25a
0.08
0.14
NA
0.375b
0.13
0.21
NA
0.5C
0.17
0.28
0.09
0.8923d
0.30
0.49
NA
* Cantaloupe
b Cucumber and tomato
c Alfalfa, carrot, clover, pepper, squash, potato, radish, turnip, soybean, and sorghum
d Turf, golf courses, ornamental uses
None of the acute risk quotients exceed the LOG for high acute risk. The LOG for
restricted use is exceeded by all uses except cantaloupe. The LOG for endangered species
has been exceeded for all use patterns.
Some additional factors influencing acute exposure are presented below, and reduce the
certainty of the risk assessment conclusions. These are as follows:
1). Small herbivores such as mice feed on a variety of food items ranging from
short grass to seeds and fruits. The residues on these other food items would be
less, yielding lower risk quotients.
2). Small insectivores feed on insects in a variety of habitats, not just those on the
surface exposed to direct spray. Insects that were underground, or otherwise
protected during spraying may have lower residue levels, also yielding lower
risk quotients. Also, the estimated residues were for small insects. Large
insects would have smaller residue levels.
3). The residues used in calculating the above risk quotients represented the
maximum expected exposure levels. It should be noted that typical exposure
levels would likely be less.
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4). The entire risk assessment for mammals is based on one LD50 value for
laboratory rats. It is not known how sensitive wild mammals may be to diquat
dibromide. If they are substantially more sensitive, they may be at greater risk
than indicated by the risk quotients above.
5). The acute oral LD50 may not be the best indicator of actual toxicity of diquat
dibromide as might occur when ingested as a dietary concentration. Diquat
dibromide binds tightly to organic matter such as food items, and may not be as
biologically available. Whereas, when intubated directly, as is done during the
acute oral test, the test animal is more likely to receive the full impact of the
test material.
6). The acute risk quotient for insectivores in turf and ornamental areas was 0.49,
which is very close to the LOG of 0.5.
Therefore, it is only with moderate certainty that the Agency concludes that
nonendangered mammals are not at acute risk from diquat dibromide. Based on risk to
mammals, diquat dibromide does exceed the restricted use LOG for all uses except cantaloupe
(application rate of 0.25 Ib cation/acre).
Information that could reduce uncertainty in the acute risk assessment for mammals
would be toxicity tests with wild mammals providing actual LC50 values. This testing is not
required for risk assessment.
Chronic Risks
Regarding chronic mammalian risks, the table below indicates the risk quotients for
each of the following application rates:
Chronic Mammalian Risk Quotients
(Chronic RQ = EEC (Maximum or typical residue value)/NOEL (80 ppm cation)
Small Mammal
Herbivores consuming
range (short) grasses
Insectivores consuming
small insects
Herbivores consuming
leafy crops
Maximum
Typical
Maximum
Typical
Maximum
Typical
Application Rates in Ibs. A.I. /A
0.25'
0.7
0.4
0.2
0.1
0.4
0.1
0.375b
1.1
0.6
0.3
0.2
0.6
0.2
0.5C
1.5*
0.8*
0.4
0.2
0.8
0.2
0.8923d
2.7
1.4
0.6
0.4
NA
NA
Cantaloupe
Cucumber and tomato
Alfalfa, carrot, clover, pepper, squash, potato, radish, turnip, soybean, and sorghum
Turf, golf courses, ornamental uses
There may be relatively few short grasses in alfalfa, clover, or soybean fields, or in some other vegetable growing fields.
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Chronic risk for mammals is based on maximum and typical residues on small
insects or leafy crops, except for the turf use, where short grasses would likely
predominate. The 2-generation rat reproduction study showed the NOEL = 80 ppm
cation and the LOEL = 240 ppm cation.
Using maximum and typical residues on food items for mammals, the risk
quotients exceed the chronic LOG for turf and ornamental use only. However, other
factors must be considered when considering the extent of risk and the probability that
chronic risk will occur such as:
1). Diquat is very persistent in the environment shown by data from terrestrial
Field Dissipation studies showing diquat does not degrade after 3 years.
However, it is bound to the soil and not taken up by plants.
2) Small herbivores such as mice actually feed on a variety of food items
ranging from short grass to seeds and fruits. These mammal species
may move about, choosing a variety of food items, not just the food
items with the maximum residues.
3). The RQ values were derived using the No Effect Level (NOEL) of 80 ppm
cation. The Lowest Effect Level (LOEL), where adverse effects were known
to occur was at the extrapolated 240 ppm cation. It is not known at what
concentration, between 80 and 240 ppm, adverse chronic effects may start to
occur. Again, including the turf use, even maximum residues on food items did
not exceed the 240 ppm.
4). Small insectivores feed on insects in a variety of habitats, not just those who are
on the surface exposed to direct spray. Insects that were underground, or
otherwise protected during spraying may have lower residue levels, also
yielding lower risk quotients. Also, the estimated residues were for small
insects. Large insects would have smaller residue levels.
These factors lead to a conclusion that while the possibility of chronic risk
exists, the probability that it will occur may be relatively low. The extent, or
significance, of chronic impact to non-endangered mammals appears to be low.
(c) Insects
Diquat dibromide poses only minimal risk to non-target insects and because it is
is practically non-toxic to honey bees, LD50 100 and 47 jig/bee, there is little direct
exposure to it.
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(2) Exposure and Risk to Nontarget Aquatic Animals
A refined EEC was done by the Agency. This EEC is determined using
environmental fate and transport computer models. The Pesticide Root Zone Model
(PRZM1) was used to simulate pesticides in field runoff and the Exposure Analysis
Modeling System (EXAMS II) to simulate pesticide fate and transport in an aquatic
environment (one acre body of water). An estimate of diquat runoff and its effect on
surface water quality was evaluated using PRZM-EXAM models from a typical crop
use on potatoes with data from a silt loam soil in Maine. This estimate is a worst case
scenario of the entire yearly application of 0.5 Ib ai/A (cation ai/A) to highly eroded
soil for 36 years. This assessment includes diquat adsorbed onto eroded soil particles
as well as diquat in the runoff water. Below is runoff as computed by EFED's PRZM-
EXAM model showing annual average Environmental Exposure Concentration of
diquat in Maine with 10% exceedance. The values are in cations ppb and the time
period is after application.
Maximum
48.4 ppb
96 hour
47.8 ppb
21 days
45.1 ppb
60 days
45.3 ppb
90 days
43.6 ppb
Diquat dibromide binds very strongly to clay and organic matter in the soil
(Koc= 100,000 in soil). The LC50 values of the aquatic organisms are from laboratory
conditions, in which there are no soil particles or plant material to bond. Therefore,
the availability of diquat to aquatic organisms in the test system would be much higher
than in a environmental setting where matter was available to "bind" with diquat
dibromide. Data from the Aquatic Dissipation study shows that diquat dissipates from
the water column in Florida ponds with half-lives of 1-2 days. Since diquat bonds very
tightly to organic matter and soil and the diquat is very stable (does not degrade); the
diquat in the runoff would dissipate rapidly to the soil bottom and not be readily
available to aquatic organisms. These factors lead to a conclusion that while the
possibility of acute or chronic risk to aquatic organisms exist, the probability that
it will occur is relatively low. Therefore, it is expected that diquat dibromide will
pose only a minimal risk to aquatic organisms from exposure to runoff.
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Estimated Residues (cations ppb) and RQ for Single Event/Single Application from Spray Drift
Contamination Rates
0.25 Ib cation/A
0.375 Ib cation/A
0.5 Ib cation/A
0.892 Ib cation/A
4.0 Ib cation/A
5% Direct Drift to 1 A Surface
0.0125 Ib cation/A
0.76 ppb cation/2M
0.0188 Ib cation/A
1.15 ppb cation/2M
0.0250 Ib cation/A
1.53 ppb cation/2M
0.0446 Ib cation/A
2.72 ppb cation/2M
0.20001b cation/A
12.2 ppb cation/2M
Risk Quotient
Invertebrates Acute: 0.002 Fish Acute:
0.00001
Fish Chronic: 0.003
Invertebrates Acute: 0.003 Fish Acute:
0.00008
Fish Chronic: 0.003
Invertebrate Acute: 0.0036
Fish Acute: 0.0001
Fish Chronic: 0.008
Invertebrate Acute: 0.006
Fish Acute: 0.0002
Fish Chronic: 0.014
Invertebrate Acute: 0.03
Fish Acute: 0.0009
Fish Chronic: 0.062
MEAN CHRONIC MATC= PPB, High acute risk RQ * 0.5, Restricted use RQ * 0.1,
Endangered Species RQ * 0.05 and Chronic RQ * 1
Estimated Residues (cations ppb) and RQ from Direct Application to Aquatic Weed Control
Contamination Rates
4.0 Ib cation/A from aerial or boat
Residues (EEC)
244.0 ppb cation in 2 meters
Risk Quotient
Estu. Invertebrates Acute: 0.6
Invertebrate Acute: 0.3
Fish Acute: 0.02
Fish Chronic: 1.24
Invertebrate Chronic: 5.5
MEAN CHRONIC MATC= PPB, High acute risk RQ * 0.5, Restricted useRQ * 0.1, Endangered Species RQ * 0.05 and Chronic RQ
(a)
Freshwater Fish
As indicated in the above estimated residue table, High Acute Risk and Endangered
Species acute LOCs for freshwater fish have not been exceeded at the maximum application
rate and for the refined EEC. The Restricted Use LOG for freshwater fish has not been
exceeded for all application rates and for the refined EEC. This indicates that the use of
diquat dibromide does not cause adverse effects to freshwater fish when exposed to the
chemical and/or residues.
As indicated in the above estimated residue table, the freshwater fish chronic LOG has
been exceeded for aquatic weed control use only and the refined EEC by 1.24 times.
Adverse impacts are not expected to freshwater fish reproductive success from the use of -
diquat dibromide.
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b. Freshwater Invertebrates
As indicated in the above estimated residue table, the freshwater invertebrate acute
LOG has not been exceeded at all application rates and the refined EEC. Therefore,
freshwater aquatic invertebrates are not likely to be adversely affected by the use of diquat
dibromide.
As indicated in the above estimated residue table, the invertebrate chronic LOG has
been exceeded at application rates for aquatic weed control use only by 5.5 times. Adverse
impacts are expected to invertebrate reproductive success from the use of diquat dibromide.
c. Estuarine and Marine Animals
As indicated in the above estimated residue table, the High Risk and Endangered
Species acute LOCs for fish have not been exceeded for the maximum application rate and for
the refined EEC. The Restricted Use LOG for fish has not been exceeded for all application
rates and for the refined EEC. This indicates that the use of diquat may not cause adverse
effects to fish when exposed to the chemical and/or its' residues.
4. Exposure and Risk to Nontarget Plants
There is relatively high certainty that drift from aerial spraying of diquat dibromide
will result in adverse effects to plants. There is an element of uncertainty in the terrestrial
plant risk assessment because data from the more sensitive plant species is probably not
available. It is likely that sweet corn and wheat would yield lower EC25's.
Non-target terrestrial plants inhabit non-aquatic areas. Non-target "semi-aquatic" plants
are plants that usually inhabit low-lying wet areas that may or may not be dry at certain times
of the year. These plants are not obligatory aquatic plants in that they do not live in a
continously aquatic environment. The terrestrial and "semi-aquatic" plants are exposed to
pesticides from runoff, drift or volatilization.
Exposure to non-target aquatic plants may occur through either runoff from terrestrial
sites, or drift from aerial application. Of course, aquatic plants are directly exposed from the
aquatic weed control use. However, since they are the "target area" for that use, risk from
such exposure is not estimated. For the aquatic weed control use, only risk caused by spray
drift from aerial treatment of aquatic weeds is assessed for the non-targets.
Spray drift exposure is determined by assuming 5% of the pesticide application will
drift over to an adjacent acreage or to a much longer distance. Runoff exposure is determined
from refined EEC from the Agency using PRZM-EXAM with conversions to Ib ai/A. This
runoff is characterized as a channelized runoff from 10 acres to a low lying areas (one acre)
some distance away that impacts "semi-aquatic" and terrestrial plants. An estimate of diquat
runoff and its effect on surface water quality was evaluated using PRZM-EXAM models from
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a typical crop use on potatoes with data from a silt loam soil in Maine. This estimate is a
worst case senario of the entire yearly application of 0.5 Ib ai/A (cation ai/A) to highly eroded
soil for 36 years. This assessment includes diquat adsorbed onto eroded soil particles as well
as diquat in the runoff water. The Estimated Environmental Concentrations are 48.4 ppb
cation (0.7934 Ib cation/A) just after application and 43.6 ppb cation 90 days after application.
However, according to the environmental fate data, diquat dibromide binds very
strongly to clay and organic matter in the soil (Koc= 100,000 in soil). Diquat is not expected
to be bioavailable to plants once it is attached to soil particles. Therefore, it is assumed that
diquat dibromide once attached to soil particles from runoff will not affect plants.
Furthermore, no EEC will be made for runoff from terrestrial treatment to non-target
terrestrial plants since it is assumed that impact to terrestrial plants will be minimal.
The EC50 values of the aquatic plants are from laboratory conditions, in which there
are no soil particles to bond. Therefore, the availablity to aquatic plants would be much
higher than in an environmental setting. Data from the Aquatic Dissipation study shows that
diquat dissipates from the water column in Florida ponds with half-lives of 1-2 days. Since
diquat bonds very tightly to organic matter and soil and the diquat is very stable (does not
degrade); the diquat in the runoff would dissipate rapidly to the soil bottom and not be
readily available to aquatic plants. Therefore, any impact on aquatic plants will come
from aerial application.
The EC25 value of the most sensitive species in the vegetative vigor study is used for
the drift exposure to terrestrial plants. For the aquatic plants, the endpoints are in EC50
values. The risk quotient is derived from the following:
- the most sensitive EC25 value (from cotton) for terrestrial plants is 0.0047 Ib
cation/A.
- the most sensitive EC50 value (from giant duckweed) for vascular aquatic plants is
0.0036 Ib cation/A when applied at surface of water as in aerial drift.
- the risk quotient is derived from dividing the exposure (EEC) by the toxicity value
(EC25 or EC50)
The following aerial EECs have been determined for non-target plants that are
exposed from the labeled application of diquat:
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Non-Target Vascular Aquatic and Terrestrial Plants Exposure to Diquat
Maximum
Application Rate (Ib
cation/A)
0.25
0.375
0.500
0.892
4.0
Use Sites
cantaloupe
cucumber, tomato,
watermelon
pepper, squash,
potato, radish,
turnip, soybean,
sorghum
turf, ornamental
aquatic weed control
Spray Drift EEC
(Ib cation/ A)
0.0125
0.0188
0.0250
0.0446
0.2000
Non-Target Plant Risk Quotients
Aquatic
3.5
5.2
6.9
12.4
55.6
Terrestrial
2.7
4.0
5.3
9.5
42.5
LOC
1.0
1.0
1.0
1.0
1.0
Endangered and non-endangered plants species have the same LOC which is 1.0.
The possibility of risk to non-target aquatic and terrestrial plants from aerial
application from all sites is relatively high. The data also suggest that exposure from drift
settling on the foliage of aquatic plants represents a greater hazard than if the drift settles on
the water first before exposure to the plants occur.
(1) Endangered Species
Levels of Concern have been exceeded for endangered species of mammals and birds
from all terrestrial use sites.
Levels of Concern have been exceeded for endangered species of aquatic invertebrates,
estuarine species, and fish from the use of diquat for aquatic weed control. It is recognized
that in places where aquatic weed control is done year after year, endangered species may
have already been eliminated. This cannot be assumed, however. Alternatively, the
possibility of future threat to endangered species may exist if diquat dibromide were to be
applied in new (previously untreated) aquatic ecosystems.
Although Levels of Concern have been exceeded for endangered species of aquatic and
estuarine invertebrates and aquatic plants by runoff exposure from fields of alfalfa, clover,
carrot, pepper, radish, potato, squash, turnip, soybean, or sorghum for endangered species of
aquatic organisms; there is a high degree of uncertainty that endangered species in these
habitats may actually be affected by runoff. The risk quotient was based on exposure
provided by the Agency's EEC model based on erodible potato fields in Maine. However,
other environmental fate data, which the model does not take into account, indicate that the
diquat that moves with the water will actually become biologically unavailable quickly as it
becomes tied up by soil and organic particles. This reduces, significantly, the possiblity of
acute effects, and makes chronic exposure extremely unlikely. Therefore, it is unlikley, in
spite of the relatively large risk quotient, that endangered aquatic organisms (fish,
invertebrates or plants) would be affected from exposure due to runoff alone.
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Endangered species of aquatic plants may be affected from drift coming from aerial
application of all terrestrial use sites and from aerial application of aquatic weed control.
Endangered species of aquatic plants in close proximity to aquatic weed control sites that use
diquat may be affected.
Endangered species of terrestrial plants may be affected by drift from aquatic weed
control or turf/ornamental use sites only.
However, the Endangered Species Protection Program has benn postponed pending
national assessment. Limitations in the use of diquat dibromide will be required to protect
endangered and threatened species, but these limitations have not been defined and may be
formulation specific. EPA anticipates that a consultation with the Fish and Wildlife Service
will be conducted in accordance with the species-based priority approach described in the
Program. After completion of consultation, registrants will be informed if any required label
modifications are necessary. Such modifications would most likely consist of the generic label
statement referring pesticide users to use limitations contained in county Bulletins.
IV. RISK MANAGEMENT AND REREGISTRATION DECISION
A. Determination of Eligibility
Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission of
relevant data concerning an active ingredient, whether products containing the active
ingredients are eligible for reregistration. The Agency has previously identified and required
the submission of the generic (i.e. active ingredient specific) data required to support
reregistration of products containing diquat dibromide active ingredients. The Agency has
completed its review of these generic data, and has determined that the data are sufficient to
support reregistration of all products containing diquat dibromide. Appendix A lists the
registered uses. Appendix B identifies the generic data requirements that the Agency reviewed
as part of its determination of reregistration eligibility of diquat dibromide, and lists the
submitted studies that the Agency found acceptable.
The data identified in Appendix B were sufficient to allow the Agency to assess the
registered uses of diquat dibromide and to determine that diquat dibromide can be used
without resulting in unreasonable adverse effects to humans and the environment. The Agency
therefore finds that all products containing diquat dibromide as the active ingredients are
eligible for reregistration. The reregistration of particular products is addressed in Section V
of this document.
The Agency made its reregistration eligibility determination based upon the target data
base required for reregistration, the current guidelines for conducting acceptable studies to
generate such data, published scientific literature, etc. and the data identified in Appendix B.
Although the Agency has found that all uses of diquat dibromide are eligible for reregistration,
it should be understood that the Agency may take appropriate regulatory action, and/or require
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the submission of additional data to support the registration of products containing diquat
dibromide, if new information comes to the Agency's attention or if the data requirements for
registration (or the guidelines for generating such data) change.
1. Eligibility Decision
Based on the reviews of the generic data for the active ingredients diquat dibromide,
the Agency has sufficient information on the health effects of diquat dibromide and on its
potential for causing adverse effects in fish and wildlife and the environment.
Therefore, the Agency concludes that products containing diquat dibromide for all uses
are eligible for reregistration. The Agency has determined that diquat dibromide products,
labeled and used as specified in this Reregistration Eligibility Decision, will not pose
unreasonable risks or adverse effects to humans or the environment.
2. Eligible and Ineligible Uses
The Agency has determined that all uses of diquat dibromide are eligible for
reregistration.
B. Regulatory Position
The following is a summary of the regulatory positions and rationales for diquat
dibromide. Where labeling revisions are imposed, specific language is set forth in Section V
of this document.
1. Tolerance Reassessment
Tolerances Listed Under 40 CFR §185.226(a)
The tolerances listed in 40 CFR §180.226(a) are for residues of the plant growth regulator
diquat (6,7-dihydrodipyrido(l,2-a:2', l'-c)pyrazinediium) derived from application of the
dibromide salt and calculated as the cation. We recommend that this 40 CFR subsection be
amended to read ".. .residues of the plant growth regulator and herbicide diquat...".
A tabular outline of tolerance reassessment summary and recommended modifications in
commodity definitions is presented in Table A. Refer to Table B for recommendations
concerning harmonization of U.S. tolerances with Codex MRLs. Based on the available data,
the following conclusions have been made regarding residues of diquat dibromide:
• Sufficient data are available to ascertain the adequacy of all established
tolerances listed in 40 CFR §180.226(a) except for sugarcane. The tolerance
for sugarcane was established to support direct application of the dibromide salt
formulation on sugarcane. There are presently no registered direct application
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uses of diquat dibromide on sugarcane. Therefore, the tolerance for sugarcane
should be revoked.
• The established tolerances of 0.1 ppm for potato and 0.02 ppm for milk are
adequate.
• The established tolerances of 0.02 ppm for the fat, meat, and meat byproducts
of cattle, goats, hogs, horses, and sheep should be raised to 0.05 ppm to
achieve compatibility with the Codex MRL.
• The established 0.02 ppm tolerance level for poultry fat, meat, meat byproduct
and eggs should be raised to 0.05 ppm to achieve compatibility with the Codex
MRL.
• The registrant has proposed tolerances of 5.0 ppm for both alfalfa and clover
seeds. The proposed tolerance level for residues in alfalfa seed appears to be
too high and a new petition with a lower tolerance level of 3.0 ppm has been
submitted. Clover seed are no longer considered to be significant food or feed
items; therefore a tolerance is not required.
• The registered uses of diquat dibromide on sorghum and soybean grown for
seed as a preharvest desiccant are supported by adequate field residue data. The
registrant has proposed a tolerance in/on sorghum seed and has committed to do
so for soybeans. The available data support tolerances of 2.0 ppm and 0.2 ppm
for sorghum and soybean seed.
• The registered uses of diquat dibromide (i) as a preharvest desiccant on carrot,
radish, and turnip grown for seed, and (ii) as a postharvest desiccant on
cantaloupe, cucumber, pepper, squash, tomato, and watermelon are considered
to be non-food uses. No residue data are required and no tolerances are
needed.
Tolerances Listed Under 40 CFR § 185.226(b)
The tolerances listed in 40 CFR § 180.226(b) are for residues of diquat calculated as the cation
derived from application of the dibromide salt to ponds, lakes, reservoirs, marshes, drainage
ditches, canals, streams, and rivers which are slow-moving or quiescent in programs of the
Corps of Engineers or other Federal or State public agencies and to ponds, lakes, and drainage
ditches only where there is little or no outflow of water and which are totally under the control
of the user.
• Sufficient data are available to ascertain the adequacy of the established
tolerances listed in 40 CFR § 180.226(b) for cucurbits vegetables, citrus fruits,
pome fruits, small fruits and berries, stone fruits, cereal grains, forage, fodder,
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and straw of cereal grains, grass forage, fodder, and hay, foliage of legume
vegetables, tree nuts, root and tuber vegetables, legume vegetables
(succulent/dried); see Table A for modifications in commodity definitions.
• The available data indicate that residues of diquat will exceed the established
tolerances of 0.02 ppm for residues in/on Brassica leafy vegetables (represented
by mustard green) and fruiting vegetables (represented by tomato). The
registrant has appropriately proposed higher tolerance levels of 0.05 ppm for
diquat residues in/on fruiting vegetables and Brassica leafy vegetables.
• No data are available for the miscellaneous commodities avocado, cottonseed,
hops, and sugarcane for which tolerances currently exist. However, we have
translated from data for other crops. Based on the highest residues found in
other irrigated crops resulting from irrigation with water containing diquat
residues, we have recommended that the registrant propose increased tolerances
from 0.02 ppm to 0.1 ppm for these crops; a petition to this end has been
submitted. If lower tolerances are desired, additional data will be required.
• The established tolerances for diquat residues in fish and shellfish at 0.1 ppm
have, as per Agency recommendation, been proposed to be increased to 2 ppm
and 20 ppm, respectively, based on data reflecting residues of diquat in fish and
shellfish from currently registered uses.
Tolerances Listed Under 40 CFR §185.2500 (a) and (b)
The tolerance listed in 40 CFR §185.2500(a) is for residues of diquat derived from application
of the dibromide salt in potable water of ponds, lakes, reservoirs, marshes, bayous, drainage
ditches, canals, streams, and rivers which are slow-moving or quiescent in programs of the
Corps of Engineers or other Federal and State public agencies.
The tolerance listed in 40 CFR §185.2500(b) is for residues of diquat derived from application
of the dibromide salt and calculated as the cation in potable water of ponds, lakes, and
drainage ditches where there is little or no outflow of water and which are totally under
control of the user.
• Since the Agency no longer establishes tolerances for residues in potable water
(47 FR 25746, 12/15/82), the tolerance for diquat dibromide has been replaced
with a designated maximum contaminant level (MCLG). An MCLG of 0.02
mg/L for residues of diquat in potable water has been established (57 FR
31776, 7/17/92). The established tolerance for residues of diquat in potable
water should be revoked.
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Tolerance Listed Under 40 CFR §185.2500(c)
The tolerance listed in 40 CFR §185.2500(c) is for residues of diquat derived from application
of the dibromide salt and calculated as the cation.
• Based on the 12x concentration factor observed in processed potatoes, a higher
tolerance of 1.0 ppm is appropriate for potatoes, granules/flakes and 0.5 ppm
potato chips. The registrant has submitted a petition to this end.
Tolerance Listed Under 40 CFR §186.2500
The tolerance listed in 40 CFR §186.2500 is for residues of diquat derived from application of
the dibromide salt and calculated as the cation.
• The potato processing data indicate that the established feed additive tolerance
for processed potato waste is appropriate.
• The soybean processing data indicate that residues of diquat concentrated 2.6x
in soybean hulls processed from soybean bearing detectable residues. No
concentration of residues was observed in other soybean processed fractions. In
accordance with Agency recommendations, the registrant has proposed a feed
additive tolerance for residues of diquat in soybean hulls; a feed additive
tolerance of 0.6 ppm would be appropriate based on a recommended tolerance
of 0.2 ppm for soybean and a concentration factor of ~3x in soybean hulls.
• The sorghum processing data indicate that residues of diquat concentrated 4x in
sorghum dry milling bran fraction processed from sorghum bearing detectable
residues. According to the revised Table II of Subdivision O's Pesticide
Assessment Guideline (PAG), the only processed commodity entry for sorghum
is flour. Residue data are not needed for flour at this time since sorghum flour
is used exclusively in the U.S. as a component of drywall, and not as either a
human or animal feed item. However, because 50% of the worldwide sorghum
production goes toward human consumption, the Agency reserves the right to
require data if needed at a later date.
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Table A. Tolerance Reassessment Summary.
Commodity
Current Tolerance (ppm)
Tolerance Reassessment (ppm)
Comment/ [Correct Commodity Definition]
Tolerances Listed Under 40 CFR §180.226(a)
Cattle, fat
Cattle, mbyp
Cattle, meat
Eggs
Goats, fat
Goats, mbyp
Goats, meat
Hogs, fat
Hogs, mbyp
Hogs, meat
Horses, fat
Horses, mbyp
Horses, meat
Milk
Potatoes
Poultry, fat
Poultry, mbyp
Poultry, meat
Sheep, fat
Sheep, mbyp
Sheep, meat
Sugarcane
0.02
0.02
0.02
0.02
0.02
0.02
0.02
0.02
0.02
0.02
0.02
0.02
0.02
0.02
0.1
0.02
0.02
0.02
0.02
0.02
0.02
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.02
0.1
0.05
0.05
0.05
0.05
0.05
0.05
Revoke
The established tolerance for ruminant and
swine commodities may be raised to
achieve compatibility with the Codex
MRL.
The established tolerance for eggs may be
raised to achieve compatibility with the
Codex MRL.
[Potato]
The established tolerance for poultry fat,
meat and meat byproducts may be raised to
achieve compatibility with Codex.
The established tolerance for ruminant
commodities may be raised to achieve
compatibility with Codex.
No registered direct application uses of
diquat dibromide on sugarcane exist.
Additional Tolerances That Have Been Proposed Under 40 CFR §180.226(a)
Alfalfa seed
Sorghum, grain
None
None
3.0
2.0
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Commodity
Current Tolerance (ppm)
Tolerance Reassessment {ppm)
Comment/ [Correct Commodity Definition]
Additional Tolerance that Needs to be Proposed Under 40 CJFR §180.226(a)
Soybean, seed
None
0.2
olerances Listed Under 40 CFR §180.226(b)
Avocados
Cottonseed
Cucurbits
Fish
Fruits, citrus
Fruits, pome
Fruits, small
Fruits, stone
Grain, crops
Grasses, forage
Hops
Legumes, forage
Nuts
Shellfish
Sugarcane
Vegetables, fruiting
Vegetables, leafy
Vegetables, root crop
Vegetables, seed and pod
0.02
0.02
0.02
0.1
0.02
0.02
0.02
0.02
0.02
0.1
0.02
0.1
0.02
0.1
0.02
0.02
0.02
0.02
0.02
0.1
0.1
0.02
2.0
0.02
0.02
0.02
0.02
0.02
0.1
0.1
0.1
0.02
20
0.1
0.05
0.05
0.02
0.02
A higher tolerance has
been proposed based on
available data.
[Cucurbits vegetables group]
A higher tolerance has been proposed
based on available data.
[Citrus fruits group]
[Pome fruits group]
[Small fruits and berries group]
[Stone fruits group]
[Cereal grains group] and [Forage, fodder,
and straw of cereal grains group]
[Grass forage, fodder, and hay group]
A higher tolerance has been proposed
based on available data.
[Foliage of legume vegetables group]
[Tree nuts group]
A higher tolerances has proposed based on
available data.
A higher tolerance has been proposed
based on available data.
A higher tolerance has been proposed
based on available data.
[Fruiting vegetables (except cucurbits)
group]
A higher tolerance has been proposed
based on available data.
[Leafy except Brassica) group] and
[Brassica leafy vegetables group]
[Root and tuber vegetables group]
[Legume vegetables (succulent/dried)
group]
Tolerance Listed Under 40 CFR §185.2500 (a) and (b)
Potable water
0.01
Revoke
A maximum contaminant level of 0.02
mg/L for residues of diquat in potable
water has been established.
Tolerances Listed Under 40 CFR §185.2500(c)
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Commodity
Processed potatoes (including potato
chips)
Current Tolerance (ppm)
0.5
0.5
Tolerance Reassessment {ppm)
1.0
0.5
Comment/ [Correct Commodity Definition]
A higher tolerance is needed based on the
12x concentration factor observed in dried
potato. [Expressed in terms of potatoes,
granules/flakes at 1.0 ppm and potato chips
at 0.5 ppm]
Tolerance Listed Under 40 CFR §186.2600
Processed potato waste
1.0
1.0
Additional Tolerance That Needs To Be Proposed Under 40 CFR §186.2600
Soybean, hulls
None
0.6
A tolerance is needed based on a
concentration factor of ~3x in soybean
hulls.
CODEX HARMONIZATION
Several maximum residue limits (MRLs) for diquat have been established by Codex in various
commodities. The diquat residues regulated by Codex and the U.S. are equivalent. The
Codex MRLs (currently expressed as the diquat cation) and U.S. tolerances derived from
application of the dibromide salt (calculated as the cation) are listed in Table D.
The U.S. tolerance for eggs, poultry, meat, and offal (mammalian) may be raised to 0.05 ppm
to achieve harmonization. Further harmonization of U.S. tolerances and Codex MRLs on
other commodities are not feasible at this time because of differences in agricultural practices.
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Table B. Codex MRLs and applicable U.S. tolerances. Recommendations for compatibility are based on
conclusions following reassessments of U.S. tolerances (see Table A).
Commodity
Barley
Beans, shelled
Cotton seed
Cotton seed oil, edible
Edible offal (Mammalian)
Eggs
Maize
Meat
Milks
Onion, Bulb
Peas, shelled
Poppy seed
Potato
Rape seed
Rapeseed oil, edible
Rice
Rice, husked
Rice, polished
Sesame seed oil, edible
Sorghum
Sugar beet
Sunflower seed
Sunflower seed oil, edible
Vegetables (except. . .) c
Wheat
Wheat bran, unprocessed
Wheat flour
Wheat whole meal
MRL
(mg/kg) a
5
0.5
1
0.1
0.05b
0.05"
0.1
0.05b
0.01b
0.1
0.1
5
0.2
2
0.1
5
0.2
0.2
0.1
2
0.1
0.5
0.1
0.05b
2
5
0.2
2
Reassessed U.S.
Tolerance (ppm)
0.02
0.02
0.02, (0.1)"
None
0.05
0.05
0.02
0.05
0.02
0.02
0.02
None
0.1
None
None
0.02
None
None
None
(2)
0.02
None
None
0.02, 0.05
0.02
None
None
None
Recommendation
Incompatible. In U.S. tolerance is for cereal
grains resulting from inadvertant water
exposure
Incompatible . As per barley except legume
vegetable group
Incompatible. U.S. use is inadvertant
irrigation
__
Compatibility will exist when current U.S.
tolerance is raised.
Compatibility will exist when current U.S.
tolerance is raised.
same as barley note
Compatibility will exist when current U.S.
tolerance is raised.
same as barley but root and tuber vegetables
group
same as barley but root and tuber vegetables
group
__
__
same as barley
__
compatible as proposed
same as onion, bulb
___
Potentially compatible if all U.S. tolerances
are increased to 0.05 ppm, provided those with
higher tolerances are excluded
same as barley
__
-
a All diquat MRLs are final (CXL).
b At or about the limit of detection.
c Except as otherwise listed.
d Parenthetic values as proposed.
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2. Risk Mitigation Measures
Aquatic Risk Mitigation Measure
The Agency maintains that the current labels for aquatic use of diquat dibromide are
satisfactory to protect aquatic organisms.
For aquatic use: Apply diquat dibromide to one-third or one-half of the dense weed
areas in a water body to be treated at any one time and recommend subsequent applications
should not be made for a further two weeks.
If diquat dibromide is applied in this fashion, the untreated part of the water body will
act as a refuge for aquatic organisms and allows time for oxygen levels to recover before
further applications are made.
Spray-Drift Risk Mitigation Measure (Non-target plants)
The possibility of risk to non-target aquatic and terrestrial plants from aerial
application for all sites is relatively high. The Agency recommends the use of the best
management practices to minimize Spray Drift.
Spray Drift Advisory
The Agency has been working with the Spray Drift Task Force, EPA Regional Offices
and State Lead Agencies for pesticide regulation to develop the best spray drift management
practices. The Agency is now requiring interim measures that must be placed on product
labels/labeling as specified in Section V. Once the Spray Drift Task Force completes their
studies, submits data, and the Agency evaluation is complete, there may be further refinement
in spray drift management practices.
3. Endangered Species Statement
The Agency has concerns about the exposure of threatened and endangered mammals
and birds to diquat dibromide in terrestrial use sites as discussed above in the environmental
assessment chapter. In addition, Levels of Concern have been exceeded for endangered
species of aquatic and estuarine invertebrates and aquatic plants by runoff exposure to diquat
dibromide. However, since diquat dibromide binds with soil and organic particles, chronic
exposure seems unlikely.
Currently, the Agency is developing a program ("The Endangered Species Protection
Program") to identify all pesticides whose use may cause adverse impacts on endangered and
threatened species and to implement measures that will eliminate the adverse impacts. The
program would require use restrictions to protect endangered and threatened species in the
county. Consultations with the Fish and Wildlife Service may be necessary to assess risks to
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newly listed species or from proposed new uses. In the future, the Agency plans to publish in
the Federal Register a description of the program and have available enforceable county-
specific bulletins. Because the Agency is taking this approach for protecting endangered and
threatened species, it is not imposing label modifications at this time through the RED. Rather,
any requirements for product use modifications will occur in the future under the Endangered
Species Protection Program.
4. Labeling Rationale
Uses within Scope of the Worker Protection Standard
The 1992 Worker Protection Standard for Agricultural Pesticides (WPS) established
certain worker-protection requirements (personal protective equipment, restricted entry
intervals, etc.) to be specified on the label of all products that contain uses within the scope of
the WPS. Uses within the scope of the WPS include all commercial (non-homeowner) and
research used on farms, forests, nurseries, and greenhouse to produce agricultural plants
(including food, feed, and fiber plants, trees, turfgrass, flowers, shrubs, ornamentals, and
seedlings). Uses within the scope include not only uses on plants, but also uses on the soil or
planting medium the plants are (or will be) grown in.
At this time some of the registered uses of diquat are within the scope of the Worker
Protection Standard for Agricultural Pesticides (WPS) and some uses are outside the scope of
the WPS. Those uses that are outside the scope of the WPS include:
Use on sites, such as ornamental gardens, parks, golf courses, and pubic or private
lawns and grounds that are intended only for decorative or environmental benefit. (However,
pesticides used on sod farms ARE covered by the WPS).
Uses not directly related to the production of agricultural plants, for example, involve
control of vegetation along rights-of-way and in other non-crop areas or aquatic weed control
in non-crop sites.
Compliance With The WPS
Any product whose labeling reasonably permits use in the production of an agricultural
plant on any farm, forest, nursery, or greenhouse must comply with the labeling requirements
of PR Notice 93-7, "Labeling Revisions Required by the Worker Protection Standard (WPS),
and PR Notice 93-11, "Supplemental Guidance for PR Notice 93-7, which reflect the
requirements of EPA's labeling regulations for worker protection statements (40 CFR part
156, subpart K). These labeling revisions are necessary to implement the Worker Protection
Standard for Agricultural Pesticides (40 CFR part 170) and must be completed in accordance
with, and within the deadlines specified in, PR Notices 93-7 and 93-11. Unless otherwise
specifically directed in this RED, all statements required by PR Notices 93-7 and 93-11 are to
be on the product label exactly as instructed in those notices.
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• After April 21, 1994, except as otherwise provided in PR Notices 93-7 and
93-11, all products within the scope of those notices must bear WPS PR Notice
complying labeling when they are distributed or sold by the primary registrant
or any supplementally registered distributor.
• After October 23, 1995, except as otherwise provided in PR Notices 93-7 and
93-11, all products within the scope of those notices must bear WPS PR Notice
complying labeling when they are distributed or sold by any person.
Personal Protective Equipment/Engineering Controls for Handlers
Occupational-Use Products (WPS and NonWPS Uses)
For each end-use product, PPE requirements for pesticide handlers will be set during
reregistration in one of two ways:
1. If EPA has no special concerns about the acute or other adverse effects of an active
ingredient, the PPE for pesticide handlers will be based on the acute toxicity of the
end-use product. For occupational-use products, PPE will be established using the
process described in PR Notice 93-7 or more recent Agency guidelines.
2. If the Agency has special concerns about an active ingredient due to very high acute
toxicity or to certain other adverse effects, such as allergic effects or delayed effects
(cancer, developmental toxicity, reproductive effects, etc):
• In the RED for that active ingredient, the Agency may establish minimum or
"baseline" handler PPE requirements that pertain to all or most occupational
end-use products containing that active ingredient.
• These minimum PPE requirements must be compared with the PPE that would
be designated on the basis of the acute toxicity of each end-use product.
• The more stringent choice for each type of PPE (i.e., bodywear, hand
protection, footwear, eyewear, etc.) must be placed on the label of the end-use
product.
There are special toxicological concerns about diquat dibromide that warrant the establishment
of active-ingredient-based PPE requirements for occupational handlers. The MOE's were
calculated as being acceptable using the assumption that coveralls over a long-sleeved shirt and
long pants, and chemical-resistant gloves were worn by all occupational handlers, including
mixers, loaders, and applicators. The use of PPE was not sufficient to reduce the MOE's to
an acceptable level for mixers and loaders using open mixing systems to support aerial
applications. Those MOE's were acceptable only with the use of closed mixing systems.
There are also special toxicological concerns about diquat dibromide stemming from the
considerable epidemiological data (mostly from California) documenting poisoning incidents
resulting from use of diquat dibromide.
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Homeowner-Use Products
EPA is not establishing minimum (baseline) handler PPE for diquat dibromide end-use
products that are intended primarily for homeowner use, since the Agency anticipates that the
frequency, duration, and degree of exposure by such users do not warrant the risk mitigation
measures imposed for occupational handlers. Personal protective equipment, if appropriate,
will be established based on the acute toxicity of the end-use product.
Post-Application/Entry Restrictions
Occupational-Use Products (WPS Uses)
Restricted Entry Interval
Under the Worker Protection Standard (WPS), interim restricted entry intervals (REI)
for all uses within the scope of the WPS are established based on the acute toxicity of the
active ingredient. The toxicity categories of the active ingredient for acute dermal toxicity,
eye irritation potential, and skin irritation potential are used to determine the interim WPS
REI. If one or more of the three acute toxicity effects are in toxicity category I, the interim
WPS REI is established at 48 hours. If none of the acute toxicity effects are in category I, but
one or more of the three is classified as category II, the interim WPS REI is established at 24
hours. If none of the three acute toxicity effects are in category I or II, the interim WPS REI
is established at 12 hours. A 48-hour REI is increased to 72 hours when an organophosphate
pesticide is applied outdoors in arid areas. In addition, the WPS specifically retains two types
of REI's established by the Agency prior to the promulgation of the WPS: (1) product-specific
REI's established on the basis of adequate data and (2) interim REI's that are longer than those
that would be established under the WPS.
Occupational Uses (WPS Uses)
For occupational end-use products containing diquat as an active ingredient, the
Agency is requiring a 7-day interim REI pertaining to each use of the product that is within
the scope of the Worker Protection Standard for Agricultural Pesticides. The basis for this
recommendation are the low MOE's following certain exposure scenarios of diquat, the
limited dissapation data regarding post-application exposure and risk from these uses, and
incidence data.
It should be noted that the WPS requirements place very specific restrictions on entry
during restricted-entry intervals, when that entry involves contact with treated surfaces. The
Agency believes that these existing WPS protection measures are sufficient to mitigate post-
application exposures of workers who have contact with surfaces treated with diquat. A 7-day
REI should not pose a significant hardship, since seed-crops are generally treated 5 to 10 days
before harvest and potatoes are treated 7 or more days before harvest. In addition, if the
crops are mechanically harvested and the harvesters and harvest-equipment operators have no
contact with the treated surfaces (soil, foliage, seed or crop being harvested, etc.), the WPS
permits them to enter the treated area during the restricted-entry interval without personal
protective equipment or any other restriction.
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The WPS REI for diquat dibromide, in effect until now, was 24 hours. The 24-hour
reentry interval was established for these uses by the 1986 Guidance for the Reregistration of
Diquat Dibromide. That reentry interval was converted into a 24-hour restricted-entry
interval through modifications specified in PR Notice 93-7, which implemented the labeling
requirements of the 1992 Worker Protection standard for Agricultural Pesticides.
Early-Entry PPE: The WPS establishes very specific restrictions on entry by workers
to areas that remain under a restricted-entry by workers if the entry involves contact with
treated surfaces. Among those restrictions are a prohibition of routine entry to perform hand
labor tasks and the requirement that personal protective equipment be worn. Personal
protective equipment requirements for persons who must enter areas that remain under a
restricted-entry interval are based on the toxicity concerns about the active ingredient. The
requirements are set in one of two ways.
1. If the Agency has no special concerns about the acute or other adverse effects of
an active ingredient, it establishes the early-entry PPE requirements based on
the acute dermal toxicity, skin irritation potential, and eye irritation potential of
the active ingredient.
2. If the Agency has special concerns about an active ingredient due to very high
acute toxicity or to certain other adverse effects, such as allergic effects,
cancer, developmental toxicity, or reproductive effects, it may establish early-
entry PPE requirements that are more stringent than would be established
otherwise.
Since the 21-day dermal toxicity studies for diquat dibromide indicate toxicity endpoints of
concern and the MOEs for certain handlers tasks are low, the Agency is requiring more
stringent PPE requirements than would be established otherwise. In addition, since diquat is
classified as toxicity category II for eye irritation potential, protective eyewear is also
required. The Agency will not require a respirator for early-entry workers, since the WPS
places very specific restrictions on early entry and these existing WPS protection measures are
sufficient to mitigate post-application inhalation exposures of workers.
Occupational-Use Products (NonWPS Uses)
For occupational end-use products containing diquat as an active ingredient, the Agency is
establishing a 4-day entry restriction for turf uses of the product on nonWPS sites, other than
aquatic sites and spot-treatments at residential sites. The basis for this requirement is the low
MOEs for certain applications of diquat and the post-application exposure assessment for these
uses. Employees (i.e., maintenance workers) at these sites are prohibited for 4 days from
contacting the treated area after application. After the sprays have settled following
application, respiratory protection should not be necessary. The entry restriction in effect
until now was 24 hours, since a 24-hour reentry interval was established for these uses by the
1986 Guidance for the Reregistration of Diquat Dibromide.
For occupational end-use products containing diquat as an active ingredient, the Agency is
retaining the 24-hour swimming prohibition for each use of the product on aquatic sites. The
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basis for this recommendation is the post-application exposure assessment for swimmers
following aquatic applications. Data demonstrates an aquatic half-life of 1 - 2 days. After that
diquat will be bound to sediment. Swimmers are prohibited from swimming in the treated
water for 24 hours.
Homeowner-Use Products
For non-occupational (homeowner) end-use products containing diquat as an active ingredient,
the Agency is establishing an entry restriction for spot-treatment applications of the product.
Although the Agency considers the potential for post-application exposures following spot
treatments at residential sites to be low, the Agency intends to further minimize the potential
for such exposures by prohibiting broadcast applications at residential sites. The basis for this
prohibition is the low MOEs for certain applications of diquat and the post-application
exposure assessment for golf-course maintenance personnel following broadcast applications to
turfgrass. The Agency does not consider entry restrictions of specified hours or days feasible
for applications at residential sites.
V. ACTIONS REQUIRED BY REGISTRANTS
This section specifies the data requirements and responses necessary for the
reregistration of both manufacturing-use and end-use products.
A. Manufacturing-Use Products
1. Additional Generic Data Requirements
The generic data base supporting the reregistration of diquat dibromide for the above
eligible uses has been reviewed and determined to be substantially complete. However,
confirmatory data are needed to fulfill requirements for the studies listed below:
Enforcement method - plant and animal commodities (Independent
Laboratory Validation)
Certain data, which are not part of the target database for diquat, are required
to support the continued registration of diquat dibromide. These data include:
Terrestrial plant studies: vegetative vigor
2. Labelling Requirements for Manufacturing-Use Products
To remain in compliance with FIFRA, manufacturing use product (MP) labeling must
be revised to comply with all current EPA regulations, PR Notices and applicable policies.
The MP labeling must bear the following statement under Directions For Use:
"Only for formulation into an herbicide, dessicant and plant growth regulator or
the applicable term which describes the type of pesticide uses(s)] for the
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following uses(s): aquatic, indoor and terrestrial food and non-food, feed crops,
outdoor residential, aquatic non-food industrial uses."
An MP registrant may, at his/her discretion, add one of the following statements to an
MP label under "Directions for Use" to permit the reformulation of the product for a specific
use or all additional uses supported by a formulator or user group:
(a) "This product may be used to formulate products for specific use(s) not
listed on the MP label if the formulator, user group, or grower has
complied with U.S. EPA submission requirements regarding the support
of such uses(s)."
(b) "This product may be used to formulate products for any additional
use(s) not listed on the MP label if the formulator, user group, or
grower has complied with U.S. EPA submission requirements regarding
the support of such uses(s)."
B. End-Use Products
1. Additional Product-Specific Data Requirements
Section 4(g)(2)(B) of FIFRA calls for the Agency to obtain any needed product-specific
data regarding the pesticide after a determination of eligibility has been made. The product
specific data requirements are listed in Appendix G, the Product Specific Data Call-in Notice.
Registrants must review previous data submissions to ensure that they meet current
EPA acceptance criteria (Appendix F; Attachment E) and if not, commit to conduct new
studies. If a registrant believes that previously submitted data meet current testing standards,
then study MRID numbers should be cited according to the instructions in the Requirement
Status and Registrants Response Form provided for each product.
2. Labeling Requirements for End-Use Products
The labels and labeling of all products must comply with EPA's current regulations and
requirements as specified in 40 CFR §156.10 and other applicable notices.
Occupational/Residential Labeling
PPE Requirements for Pesticide Handlers
Sole-active-ingredient end-use products that contain diquat dibromide must be revised
to adopt the handler personal protective equipment requirements set forth in this section. Any
conflicting PPE requirements on their current labeling must be removed.
Multiple-active-ingredient end-use products that contain diquat dibromide must
compare the handler personal protective equipment requirements set forth in this section to the
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PPE requirements on their current labeling and retain the more protective. For guidance on
which PPE is considered more protective, see PR Notice 93-7.
Products Intended Primarily for Occupational Use
Minimum (baseline) PPE requirements — Some of the registered uses of diquat
dibromide are within the scope of the Worker Protection Standard for Agricultural Pesticides
(WPS) and some are outside the scope of the WPS. The minimum (baseline) PPE
requirements pertain to both the WPS and nonWPS uses by occupational handlers, since the
potential exposure to occupational handlers is similar for WPS and nonWPS uses.
The minimum (baseline) PPE for all WPS and nonWPS occupational uses of diquat
dibromide end-use products is:
"Applicators and other handlers must wear:
—Coveralls over long-sleeved shirt and long pants
—Chemical-resistant gloves (see instructions * below)
—Chemical-resistant footwear plus socks
—Chemical-resistant headgear for overhead exposure
—Chemical-resistant apron when cleaning equipment, mixing, or loading" (see
instructions ** below)
—A dust/mist filtering respirator (MSHA/ NIOSH approval number prefix
TC-21C)
* The glove statement for diquat dibromide is the statement established
through the instructions in Supplement Three of PR Notice 93-7.
** The words "mixing, or loading" may be removed if the product is
formulated as "ready-to-use."
Actual end-use product PPE requirements — The PPE that would otherwise be
established based on the acute toxicity of each end-use product must be compared to the
minimum (baseline) personal protective equipment, if any, specified above. The more
protective PPE must be placed on the product labeling. For guidance on which PPE is
considered more protective, see PR Notice 93-7.
Placement in labeling — The personal protective equipment must be placed on the
end-use product labeling in the location specified in PR Notice 93-7 and the format and
language of the PPE requirements must be the same as is specified in PR Notice 93-7.
Products Intended Primarily for Homeowner Use
Personal protective equipment requirements — EPA is not establishing minimum
(baseline) handler PPE for diquat dibromide end-use products that are intended primarily for
homeowner use. Personal protective equipment, if appropriate, will be established based on
the acute toxicity of the end-use product.
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Placement in labeling — The personal protective equipment requirements, if any, must
be placed on the end-use product labeling immediately following the precautionary statements
in the labeling section "Hazards to Humans (and domestic animals)."
Entry Restrictions
Sole-active-ingredient end-use products that contain diquat dibromide must be
revised to adopt the entry restrictions set forth in this section. Any conflicting entry
restrictions on their current labeling must be removed.
Multiple-active-ingredient end-use products that contain diquat dibromide must
compare the entry restrictions set forth in this section to the entry restrictions on their
current labeling and retain the more protective. A specific time-period in hours or days
is considered more protective than "sprays have dried" or "dusts have settled."
Products Intended Primarily for Occupational Use
WPS uses
Restricted-entry interval — A 7-day entry interval (REI) is required for uses within
the scope of the WPS (see PR Notice 93-7) on all end-use products (see tests in PR Notices
93-7 and 93-11). This REI must be inserted into the standardized REI statement required by
Supplement Three of PR Notice 93-7.
Early-entry personal protective equipment (PPE) —
The PPE required for early entry is:
—coveralls over long-sleeve shirt and long pants,
—chemical-resistant gloves,
—chemical-resistant footwear plus socks,
—chemical-resistant headgear for overhead exposures,
—protective eyewear.
Placement in labeling — The REI must be inserted into the standardized REI statement
required by Supplement Three of PR Notice 93-7. The PPE required for early entry must be
inserted into the standardized early entry PPE statement required by Supplement Three of PR
Notice 93-7.
NonWPS uses
Entry restrictions —
For applications to nonWPS sites (other than aquatic sites residential sites),
such as golf courses, parks, etc:
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"For 4 days following applications to non-crop areas (other than aquatic or residential
sites), do not allow employees to have contact with the treated plants, except for
contact with their footwear."
For spot-treatment applications to residential sites:
"Do not allow people or pets to touch treated plants until the sprays have dried."
Placement in labeling —
If WPS uses are also on label: Follow the instructions in PR Notice 93-7 for
establishing a Non-Agricultural Use Requirements box and place the appropriate
nonWPS entry restriction in that box.
If no WPS uses are on label: Add the appropriate nonWPS entry restriction to
the labels of all end-use products, except products primarily intended for
homeowner use, in a section in the Directions For Use with the heading: "Entry
Restrictions:"
Products Intended Primarily for Home Use
Entry restrictions —
"Do not allow people or pets to touch treated plants until the sprays have dried."
Placement in labeling — Add the entry restriction to the labels of products
primarily intended for homeowner use in a section in the Directions For Use with the heading:
"Entry Restrictions:"
Other Labeling Requirements
Products Intended Primarily for Occupational Use
The Agency is requiring the following labeling statements to be located on all end-use
products containing diquat dibromide that are intended primarily for occupational use.
Application Restrictions:
"Do not apply this product in a way that will contact workers or
other persons, either directly or through drift. Only protected
handlers may be in the area during application."
Engineering Controls:
"Mixers and loaders supporting aerial applications are required to
use closed systems. The closed system must be used in a manner
that meets the requirements listed in the Worker Protection
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Standard (WPS) for agricultural pesticides (40 CFR
170.240(d) (4). When using the closed system, the mixers' and
loaders' PPE requirements may be reduced or modified as
specified in the WPS."
"When handlers use closed systems, enclosed cabs, or aircraft in
a manner that meets the requirements listed in the Worker
Protection Standard (WPS) for agricultural pesticides (40 CFR
170.240(d)(4-6), the handler PPE requirements may be reduced
or modified as specified in the WPS."
User Safety Requirements:
"Follow manufacturer's instructions for cleaning/maintaining
PPE. If no such instructions exist for washables, use detergent
and hot water. Keep and wash PPE separately from other
laundry."
User Safety Recommendations:
• "Users should wash hands before eating, drinking, chewing gum,
using tobacco, or using the toilet."
• "Users should remove clothing immediately if pesticide gets
inside. Then wash thoroughly and put on clean clothing."
• "Users should remove PPE immediately after handling this
product. Wash the outside of gloves before removing. As soon as
possible, wash thoroughly and change into clean clothing."
Products Intended Primarily for Homeowner Use
The Agency is requiring the following labeling statements to be located on all end-use
products containing diquat dibromide that are intended primarily for homeowner use.
Application Restrictions:
"Do not apply this product in a way that will contact any person
or pet, either directly or through drift. Only persons applying
this product may be in the area during application."
User Safety Recommendations:
• "Clothing and protective equipment exposed to this
product should be washed in detergent and hot water.
Such items should be kept and washed separately from
other laundry."
79
-------
• "Users should wash hands before eating, drinking,
chewing gum, using tobacco, or using the toilet."
• "Users should remove clothing immediately if pesticide
gets inside. Then wash thoroughly and put on clean
clothing."
• "Users should remove PPE immediately after handling
this product. Wash the outside of gloves before removing.
As soon as possible, wash thoroughly and change into
clean clothing."
Environmental Hazard
Environmental hazard requires the following label statements:
For products that are for terrestrial nonfood sites, use this precautionary
statement: "This pesticide is toxic to aquatic invertebrates. Do not apply directly
to water, or to areas where surface water is present or to intertidal areas below
the mean high water mark. Do not contaminate water when disposing of
equipment washwater or rinsate."
For products that are for outdoor residential sites, use this precautionary
statement: "This pesticide is toxic to aquatic invertebrates. Do not apply directly
to water."
C. Spray Drift Label Advisory
Aerial Spray Drift Management
The following language must be placed on each product label that can be applied aerially:
SPRAY DRIFT MANAGEMENT
AVOIDING SPRAY DRIFT AT THE APPLICATION SITE IS THE RESPONSIBILITY OF
THE APPLICATOR AND THE GROWER.
The interaction of many equipment-and-weather-related factors determine the potential for
spray drift. The applicator and the grower are responsible for considering all these factors
when making decisions.
The following drift management requirements must be followed to avoid off-target movement
from aerial applications to agricultural field crops. These requirements do not apply to
forestry applications, public health uses or to applications using dry formulations.
80
-------
1. The distance of the outer most nozzles on the boom must not exceed 3/4 the length of
the wingspan or rotor.
2. Nozzles must always point backward parallel with the air stream and never be pointed
downwards more than 45 degrees.
Where states have more stringent regulations, they should be observed.
The applicator should be familiar with and take into account the information covered in the
Aerial Drift Reduction Advisory.
Aerial Drift Reduction Advisory Information
The following aerial drift advisory information must be contained in the product labeling:
[This section is advisory in nature and does not supersede the mandatory label requirements.]
INFORMATION ON DROPLET SIZE
The most effective way to reduce drift potential is to apply large droplets. The best drift
management strategy is to apply the largest droplets that provide sufficient coverage and
control. Applying larger droplets reduces drift potential, but will not prevent drift if
applications are made improperly, or under unfavorable environmental conditions (See Wind,
Temperature and Humidity, and Temperature Inversions).
CONTROLLING DROPLET SIZE
• Volume - Use high flow rate nozzles to apply the highest practical spray volume.
Nozzles with higher rated flows produce larger droplets.
• Pressure - Do not exceed the nozzle manufacturer's recommended pressures. For
many nozzle types lower pressure produces larger droplets. When higher flow rates
are needed, use higher flow rate nozzles instead of increasing pressure.
• Number of nozzles - Use the minimum number of nozzles that provide uniform
coverage.
• Nozzle Orientation - Orienting nozzles so that the spray is released parallel to the
airstream produces larger droplets than other orientations and is the recommended
practice. Significant deflection from horizontal will reduce droplet size and increase
drift potential.
• Nozzle Type - Use a nozzle type that is designed for the intended application. With
most nozzle types, narrower spray angles produce larger droplets. Consider using low-
drift nozzles. Solid stream nozzles oriented straight back produce the largest droplets
and the lowest drift.
81
-------
BOOM LENGTH
For some use patterns, reducing the effective boom length to less than 3/4 of the wingspan or
rotor length may further reduce drift without reducing swath width.
APPLICATION HEIGHT
Applications should not be made at a height greater than 10 feet above the top of the target
plants unless a greater height is required for aircraft safety. Making applications at the lowest
height that is safe reduces exposure of droplets to evaporation and wind.
SWATH ADJUSTMENT
When applications are made with a crosswind, the swath will be displaced downwind.
Therefore, on the up and downwind edges of the field, the applicator must compensate for this
displacement by adjusting the path of the aircraft upwind. Swath adjustment distance should
increase, with increasing drift potential (higher wind, smaller drops, etc.).
WIND
Drift potential is lowest between winds speeds of 3 - 10 mph. However, many factors,
including droplet size and equipment type determine drift potential at any given speed.
Application should be avoided below 3 mph due to variable wind direction and high inversion
potential. NOTE: Local terrain can influence wind patterns. Every applicator should be
familiar with local wind patterns and how they affect spray drift.
TEMPERATURE AND HUMIDITY
When making applications in low relative humidity, set up equipment to produce larger
droplets to compensate for evaporation. Droplet evaporation is most severe when conditions
are both hot and dry.
TEMPERATURE INVERSIONS
Applications should not occur during a temperature inversion because drift potential is high.
Temperature inversions restrict vertical air mixing, which causes small suspended droplets to
remain in a concentrated cloud. This cloud can move in unpredictable directions due to the
light variable winds common during inversions. Temperature inversions are characterized by
increasing temperatures with altitude and are common on nights with limited cloud cover and
light to no wind. They begin to form as the sun sets and often continue into the morning.
Their presence can be indicated by ground fog; however, if fog is not present, inversions can
also be identified by the movement of smoke from a ground source or an aircraft smoke
generator. Smoke that layers and moves laterally in a concentrated cloud ( under low wind
conditions) indicates an inversion, while smoke that moves upward and rapidly dissipates
indicates good vertical air mixing.
82
-------
SENSITIVE AREAS
The pesticide should only be applied when the wind is blowing away from adjacent sensitive
areas (e.g. residential areas, bodies of water, known habitat for threatened or endangered
species, non-target crops).
D. Labeling for Endangered Species
No use limitations to protect endangered plant species will be suggested until the OPP
Endangered Species Protection Program is complete.
E. Existing Stocks
Registrants may generally distribute and sell products bearing old labels/labeling for 26
months from the date of the issuance of this Reregistration Eligibility Decision (RED).
Persons other than the registrant may generally distribute or sell such products for 50 months
from the date of the issuance of this RED. However, existing stocks time frames will be
established case-by-case, depending on the number of products involved, the number of label
changes, and other factors. Refer to "Existing Stocks of Pesticide Products; Statement of
Policy"; Federal Register, Volume 56, No. 123, June 26, 1991.
The Agency has determined that registrants may distribute and sell products bearing
old labels/labeling, i.e., labels absent the modifications specified in this RED document,
except as noted below, for 26 months from the date of issuance of this RED. Persons other
than the registrant may distribute or sell such products for 50 months from the date of the
issuance of this RED. Registrants and persons other than registrants remain obligated to meet
pre-existing Agency imposed label changes and existing stocks requirements applicable to
products they sell or distribute.
83
-------
84
-------
VI. APPENDICES
85
-------
86
-------
APPENDIX A. Table of Use Patterns Subject to Reregistration
87
-------
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 1
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES
AGRICULTURAL DRAINAGE SYSTEMS
Aquatic deep water injection/bottom
placement application., Spring., Weighted
trailing hose.
Aquatic deep water injection/bottom
placement application., Summer., Weighted
trailing hose.
Aquatic deep water injection/bottom
placement application., When needed.,
Weighted trailing hose.
Aquatic subsurface injection application.
When needed., Trailing hose.
Edging treatment., Prebloom., Sprayer.
Pour-on., When needed., Boat.
Shoreline treatment., Prebloom., Sprayer.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
Use Group: AQUATIC FOOD CROP
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
2 Ib (CI) A * NS NS
2 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
2 Ib (CI) -- * NS NS
1.66 Ib (CI) -- * NS NS
2 Ib (CI) -- * NS NS
2.16 Ib (CI) -- * NS NS
2 Ib (CI) -- * NS NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS NS NS TN
NS NS NS AL
NS NS
NS AN
NS NS
NS AN
NS NS
NS AN
NS AN
NS AN
NS AN
NS AN
NS AN
NS FL
NS
NS FL
NS FL
NS
NS
1
1
NS
NS
NS
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C46, C86, C92, C98,
CA1, GK6
C89, C90, C91
C46,
CA1,
C89,
C89,
C86,
C91,
C46,
CA1,
C86,
C86,
C86,
C91
C86,
C86,
C92
C86, C92, C98,
GK6
C90, C91
C90, C91
CSS, C89, C90,
CAE
C86, C92, C98,
GK6
CSS, C90, C91
C90, C91
CSS, C89, C90,
C89, C90, C91
C89, C90, C91,
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
AGRICULTURAL DRAINAGE SYSTEMS (con't)
Use Group: AQUATIC FOOD CROP (con't)
Spray., Foliar., Sprayer.
Water application., Foliar., Sprayer.
Water application., When needed., Boat.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
UC
.01042 Ib (CI) --
.02031 Ib (CI) --
2 Ib (CI) --
1.92 Ib (CI) --
1.5 Ib (CI) A
1.245 Ib (CI) A
UC
UC
1.5 Ib (CI) A
1.5 Ib (CI) A
UC
1.245 Ib (CI) A
2 Ib (CI) --
.01563 Ib (CI) --
1.66 Ib (CI) --
UC
UC
4 Ib (CI) A
3.486 Ib (CI)
A-ft
4 Ib (CI) A
* NS
*
* NS
* NS
* NS
* NS
* NS
* NS
* NS
*
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
NS
AN
AN
AN
NS
NS
NS
AN
AN
NS
NS
14
AN
AN
AN
NS
NS
NS NY
NS
1
1
NS
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
CSS,
FL C86,
C91
C40,
C99
C46,
C91
C86,
C86,
CSS,
C86,
C91
C86,
C86,
C91
C86,
C92
FL C86,
C91
FL C86,
FL C90,
FL C90,
C46,
C92
C86,
C91
C86,
C91,
C89,
CSS,
CSS,
C86,
CSS,
C90,
C89,
CSS,
C90,
CSS,
C89,
CSS,
CSS,
C91,
C91,
C89,
CSS,
CSS,
CAE
C90,
C89,
C90,
CSS,
C90,
C91
C90,
C89,
C91
C89,
C90,
C89,
C90,
CAE
CAE
C90,
C89,
C89,
C91
C90,
C91,
C90,
C91
C91
C90,
C90,
C91,
C90,
C91
C91,
C90,
C90,
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0) Page 3
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
AGRICULTURAL DRAINAGE SYSTEMS (con't)
Use Group: AQUATIC FOOD CROP (con't)
Water treatment (subsurface)., When needed., SC/L NA
Boat.
Water treatment (subsurface)., When needed., SC/L NA
Injection.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
2.16 Ib (CI) A
4 Ib (CI) A
4 Ib (CI) A
UC
3.984 Ib (CI)
A-ft
4.2 Ib (CI) A-ft
UC
4.2 Ib (CI) A-ft
4 Ib (CI) A
4 Ib (CI) A-ft
3.32 Ib (CI) A
UC
4.2 Ib (CI) A-ft
UC
UC
4.2 Ib (CI) A-ft
4 Ib (CI) A
4 Ib (CI) A-ft
UC
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
*
* NS
* NS
* NS
* NS
* NS
*
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
NS
NS
14
AN
AN
AN
AN
14
14
AN
AN
AN
AN
NS
NS
NS
NS
NS
1
1
1
1
NS
1
NS
1
1
1
NS
SC/L NA
C86, C89, C90, C91
C86, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
CSS, C89, C90, C91
C86, C90, C91
C90, C91, CAE
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
CSS, C89, C90, C91
C46, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0) Page 4
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
AGRICULTURAL DRAINAGE SYSTEMS (con't)
SC/L NA
SC/L NA
SC/L NA
Use Group: AQUATIC FOOD CROP (con't)
4 Ib (CI) A
NS NS
UC * NS NS
4 Ib (CI) A * NS NS
NS
NS
NS AN
NS AN
NS AN
NS
NS
C86, CSS, C89, C90,
C91, CAE
C86, C89, C90, C91
C86, C89, C90, C91,
C92
Water treatment (surface)., Spring.,
Sprayer.
Water treatment (surface)., Summer.,
Sprayer.
Water treatment (surface)., When needed.
Aircraft.
Water treatment (surface)., When needed.
Boat.
Water treatment (surface)., When needed.
Boom sprayer.
Water treatment (surface)., When needed.
Injection.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
4 Ib (CI) A
NS NS
NS AN
3.984 Ib (CI) * NS NS
A-ft
4 Ib (CI) A
4 Ib (CI) A * NS
4 Ib (CI) A
4 Ib (CI) A * NS
1.5 Ib (CI) A
NS NS
1.5 Ib (CI) A * NS NS
4.2 Ib (CI) A-ft * NS NS
4.2 Ib (CI) A-ft
NS NS
4 Ib (CI) A-ft * NS NS
4 Ib (CI) A * NS NS
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C46, C86, C92, C98,
CA1, GK6
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
14
AN
AN
AN
NS FL
1
1
1
NS NY
C89,
C86,
C86,
C91
CSS,
C40,
C90,
C90,
CSS,
C89,
CSS,
C91
C91
C89, C90,
C90, C91
C90, C91,
4.2 Ib (CI) A-ft
NS NS
C86, C90, C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0) Page 5
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
AGRICULTURAL DRAINAGE SYSTEMS (con't)
Water treatment (surface)., When needed.,
Sprayer.
Water treatment., When needed., Helicopter.
AGRICULTURAL/FARM PREMISES
Spray., When needed., Sprayer.
ALFALFA
Desiccation. Use Pesticide Type code "43".,
Seed crop., Aircraft.
Desiccation. Use Pesticide Type code "43".,
Seed crop., Ground.
BERMUDAGRASS
Broadcast., Dormant., Ground.
Use Group: AQUATIC FOOD CROP (con't)
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
4.2 Ib (CI) A-ft
4 Ib (CI) A * NS
NS
NS
4 Ib (CI) A * NS NS NS
20 Ib (CI) * NS NS NS
Use Group: TERRESTRIAL FOOD CROP
.01042 Ib (CI) * NS NS NS
Use Group: TERRESTRIAL FEED CROP
.5 Ib (CI) A * NS NS NS
.5 Ib (CI) A * NS NS NS
.5 Ib (CI) A * NS NS NS
.5 Ib (CI) A * NS NS NS
Use Group: TERRESTRIAL FEED CROP
.5 Ib (CI) A * NS NS NS
NS AN
NS AN
NS NS
NS
NS FL
NS FL
C86, CSS, C89, C90,
C91
C46, C86, C92, C98,
CA1, GK6
C89, C90, C91
C89, C90, C91
C46, C86, C92, C98,
CA1, GK6
C14, C46, C86, C92,
C98, CA1, G88, GK6,
GL5, H03
C14, C46, C89, C90,
C91, C92
C14, C46, C86, C92,
C98, CA1, G88, GK6,
GL5, H03
C14, C46, C89, C90,
C91, C92
C46, C86, C92, C98,
CA1, GK6
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
.5 Ib
.5 Ib
.5 Ib
.5 Ib
.5 Ib
(CI) --
(CI) --
(CI) --
(CI) --
(CI) --
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AR
LA
MS
OK
OK
C46
C46
C46
C46
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0) Page 6
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
BERMUDAGRASS (con't)
Directed spray., Dormant., Sprayer.
Directed spray., Dormant., Sprinkler can.
Directed spray., Dormant., Squeeze
applicator.
Spot treatment., Dormant., Sprinkler can.
Spray., When needed., Sprayer.
CARROT (INCLUDING TOPS)
Desiccation. Use Pesticide Type code "43"
Preharvest., Aircraft.
Desiccation. Use Pesticide Type code "43"
Seed crop., Aircraft.
Desiccation. Use Pesticide Type code "43"
Seed crop., Ground.
CUCUMBER
Spray., Post-final harvest., Sprayer.
GREENHOUSES-IN USE
Use Group: TERRESTRIAL FEED CROP (con't)
SC/L
SC/L
RTU
RTU
RTU
RTU
SC/L
NA
NA
NA
NA
NA
NA
NA
.5 Ib (CI) -- * NS
.5 Ib (CI) -- * NS
UC * NS
UC * NS
UC * NS
UC * NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS TN
NS TX
NS
NS
NS
NS
NS
C46
C46
CAE,
CAE,
CAE,
CAE,
C46,
CAG,
CAG,
CAG,
CAG,
C86,
G74
GL8
GL8
GL8
CSS
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
Use Group: TERRESTRIAL FOOD CROP
.5 Ib (CI) A * NS NS NS NS
Use Group: TERRESTRIAL FEED CROP
.5 Ib (CI) A * NS NS NS NS
.5 Ib (CI) A * NS NS NS NS
.5 Ib (CI) A * NS NS NS NS
.5 Ib (CI) A
NS
NS
NS
NS
NS
Use Group: TERRESTRIAL FOOD CROP
.375 Ib (CI) A * NS NS NS NS NS
.375 Ib (CI) A * NS NS NS NS NS
Use Group: GREENHOUSE FOOD CROP
NS FL
NS FL
C91, GA4
C14, C46, GI7,
HOI(3)
C14, C46, C86, C92,
C98, CA1, G88, GK6,
GL5, H03
C14, C46, C89, C90,
C91, C92
C14, C46, C86, C92,
C98, CA1, G88, GK6,
GL5, H03
C14, C46, C89, C90,
C91, C92
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0) Page 7
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
GREENHOUSES-IN USE (con't)
Indoor premise treatment., When needed.,
Sprayer.
Use Group: GREENHOUSE FOOD CROP (con't)
Indoor premise treatment., When needed.,
Trigger spray bottle.
Spray., When needed., Sprayer.
IRRIGATION SYSTEMS
Shoreline treatment., Prebloom., Sprayer.
Water treatment (subsurface)., When needed., SC/L NA
Injection.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.013
.013
.01038
.01894
.01042
.01042
1
.01042
.013
.5
.01016
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
.009727
.01016
1
2
.01042
4 Ib
Ib
Ib
Ib
Ib
UC *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
UC *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
UC *
(CI) -- *
Ib (CI) *
(CI) -- *
(CI) -- *
Use Group
(CI) -- *
(CI) -- *
(CI) A-ft *
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
: AQUATIC
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
FOOD CROP
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
1
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
1
NS
NS
NS
1
C86, CSS, C89, C90,
C91
C86, C90, C91
CAE
C46,
CA1,
C86,
C91
C86,
C91,
C86,
C92
CSS,
CSS,
C90,
C92
C46,
C91,
C86,
C46,
C92
C86, C92, C98,
GK6
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91,
C89, C90, C91
C90, C91
C91, CAE
C86, CSS, C90,
GA4
CSS, C90, C91
C89, C90, C91,
C86, CSS, C89, C90,
C91
CSS, C89, C90, C91
C86, CSS, C89, C90,
C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0) Page
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
IRRIGATION SYSTEMS (con't)
Use Group: AQUATIC FOOD CROP (con't)
SC/L NA
Water treatment (surface)., When needed., SC/L NA
Boat.
SC/L NA
LAKES/PONDS/RESERVOIRS (WITH HUMAN OR WILDLIFE USE)
Aquatic deep water injection/bottom SC/L NA
placement application., Spring., Weighted
trailing hose.
SC/L NA
Aquatic deep water injection/bottom SC/L NA
placement application., Summer., Weighted
trailing hose.
SC/L NA
Aquatic deep water injection/bottom SC/L NA
placement application., When needed.,
Weighted trailing hose.
SC/L NA
Aquatic subsurface injection application., SC/L NA
When needed., Trailing hose.
Edging treatment., Prebloom., Sprayer.
Injection treatment., When needed.,
Injection.
Pour-on., When needed., Boat.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
4 Ib (CI) A-ft
4 Ib (CI) A-ft
NS
NS
NS
NS
NS
NS
4 Ib (CI) A-ft * NS NS NS
Use Group: AQUATIC FOOD CROP
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
2 Ib (CI) A * NS NS
2 Ib (CI) A * NS NS
.083 Ib (CI) * NS NS
injection
3.984 Ib (CI) A * NS NS
NS
NS
NS
NS
NS
NS AN
NS AN
NS AN
NS NS
NS AN
NS NS
NS AN
NS NS NS AL
NS NS NS TN
NS AN NS
NS NS NS FL
NS AN NS
NS FL
NS FL
NS
1
CSS, C89, C90, C91
C86, CSS, C89, C90,
C91
CSS, C89, C90, C91
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C46, C86, C92, C98,
CA1, GK6
C89, C90, C91
C46, C86, C92, C98,
CA1, GK6
C89, C90, C91
C89, C90, C91
C86, CSS, C89, C90,
C91, CAE
C46, C86, CSS, C90,
C91, GA4
C46, C86, CSS, C90,
C91, GA4
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0) Page 9
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
LAKES/PONDS/RESERVOIRS (WITH HUMAN OR WILDLIFE USE) (con't)
SC/L NA
Shoreline treatment., Prebloom., Sprayer.
Use Group: AQUATIC FOOD CROP (con't)
4 Ib (CI) A
Spray., Foliar., Sprayer.
Spray., When needed., Sprayer.
Water application., Foliar., Sprayer.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
2 Ib
1.66 Ib
2 Ib
2.16 Ib
2 Ib
.01042 Ib
.02031 Ib
2 Ib
1.92 Ib
1.5 Ib
1.245 Ib
1.5 Ib
1.5 Ib
1.245 Ib
1.92 Ib
2 Ib
(CI) --
(CI) --
(CD --
(CD --
(CD --
uc
(CI) --
(CI) --
(CI) --
(CI) --
(CI) A
(CI) A
uc
uc
(CI) A
(CI) A
uc
(CI) A
(ci) --
(CI) --
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
*
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
NS
AN
AN
AN
NS
NS
NS
NS
AN
1
1
NS
NS
NS
NS
NS
NS NY
NS
1
1
NS
1
1
NS
NS
NS
C46, C86, C92, C98,
CA1, GK6
C86, CSS, C90, C91
C86, C90, C91
C86, CSS, C89, C90,
C91
C86, C89, C90, C91
C86, C89, C90, C91,
C92
CSS, C89, C90, C91
C86,
C91
C40,
C99
C46,
C91
C86,
C86,
CSS,
C86,
C91
C86,
C86,
C91
C46,
C91
C86,
C92
CSS, C89,
CSS, C90,
C86, CSS,
CSS, C90,
C90, C91
C89, C90,
CSS, C89,
C90, C91
CSS, C89,
C86, CSS,
C89, C90,
C91
C90,
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 10
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
LAKES/PONDS/RESERVOIRS (WITH HUMAN OR WILDLIFE USE) (con't)
Use Group: AQUATIC FOOD CROP (con't)
Water application., When needed., Boat.
Water treatment (subsurface)., When needed., SC/L NA
Boat.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.01563 Ib (CI) --
1.66 Ib (CI) --
UC
UC
4 Ib (CI) A
3.486 Ib (CI)
A-ft
4 Ib (CI) A
2.16 Ib (CI) A
4 Ib (CI) A
4 Ib (CI) A
UC
3.984 Ib (CI)
A-ft
4.2 Ib (CI) A-ft
UC
4.2 Ib (CI) A-ft
4 Ib (CI) A
4 Ib (CI) A-ft
3.32 Ib (CI) A
UC
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
*
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
NS
NS
14
AN
AN
AN
AN
AN
AN
NS
NS
14
AN
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
1
1
1
NS
FL C86,
C91
FL C86,
FL C90,
FL C90,
C46,
C91,
C86,
C91
C86,
C91,
C86,
C86,
C92
FL C86,
C91
C86,
C91
FL C86,
C86,
C86,
C91
C86,
C86,
CSS,
CSS,
CSS,
C91,
C91,
CSS,
C92
CSS,
CSS,
CAE
C89,
C89,
CSS,
CSS,
CSS,
C90,
CSS,
CSS,
C90,
C89,
C89,
C90,
CAE
CAE
C89,
C89,
C89,
C90,
C90,
C89,
C89,
C90,
C91
C89,
C90,
C91
C90,
C90,
C91
C90,
C90,
C90,
C91
C91,
C90,
C90,
C91
C90,
C91
C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 11
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
LAKES/PONDS/RESERVOIRS (WITH HUMAN OR WILDLIFE USE) (con't)
Water treatment (subsurface)., When needed., SC/L NA
Injection.
Use Group: AQUATIC FOOD CROP (con't)
4.2 Ib (CI) A-ft
C86, C90, C91
Water treatment (surface)., Spring.,
Sprayer.
Water treatment (surface)., Summer.,
Sprayer.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
4.2 Ib
4
4 Ib
4 Ib
4
4
4
3.
UC
UC
(CI) A-ft
Ib
(CI) A
(CI) A-ft
UC
UC
(CI) A-ft
Ib
Ib
Ib
(CI) A
UC
(CI) A
(CI) A
84 Ib (CI)
injection
3.984
4
4
4
4
Ib
Ib
Ib
Ib
Ib (CI)
A-ft
(CI) A
(CI) A
(CI) A
(CI) A
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
14
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS
1
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS AL
NS TN
NS AL
NS TN
C90,
C86,
C91
C86,
CSS,
C46,
C91,
C86,
C91
C86,
C91,
C86,
C86,
C92
C86,
C91
C46,
C91
C86,
C91, CAE
CSS, C89,
CSS, C90,
C89, C90,
CSS, C89,
C92
C90,
C91
C91
C90,
CSS, C89, C90,
CSS, C89,
CAE
C89, C90,
C89, C90,
CSS, C89,
C86, CSS,
CSS, C90,
C90,
C91
C91,
C90,
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 12
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
LAKES/PONDS/RESERVOIRS (WITH HUMAN OR WILDLIFE USE) (con't)
Water treatment (surface)., When needed.,
Aircraft.
Water treatment (surface)., When needed.,
Boat.
Water treatment (surface)., When needed.,
Boom sprayer.
Water treatment (surface)., When needed.,
Injection.
Water treatment (surface)., When needed.,
Sprayer.
Water treatment., When needed., Helicopter. SC/L NA
MELONS, CANTALOUPE
Spray., Post-final harvest., Sprayer.
MELONS, WATER
Spray., Post-final harvest., Sprayer.
•E USE) (con'
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
t)
1.5
1.5
4.2 Ib
4.2 Ib
4 Ib
4 Ib
4
4.2 Ib
4.2 Ib
4
4
1.92
20
.25
.25
.375
.375
Ib
Ib
Use Group
(CI) A *
(CI) A *
(CI) A-ft *
(CI) A-ft *
(CI) A-ft *
(CI) A-ft *
Ib
(CI) A *
(CI) A-ft *
(CI) A-ft *
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
(CI) A *
(CI) A *
(CI) A *
(CI) A *
Use Group
(CI) A *
(CI) A *
Use Group
(CI) A *
(CI) A *
: AQUATIC FOOD CROP (con
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
FOOD CROP
NS
NS
FOOD CROP
NS
NS
't)
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
NS
14
AN
AN
AN
AN
14
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS
NS FL
1
1
1
NS
NS NY
1
1
NS
NS FL
NS
NS FL
NS FL
NS FL
NS FL
NS FL
FL C46, C86, C92, C98,
CA1 , GK6
C89, C90, C91
C86, C90, C91
C86, CSS, C89, C90,
C91
CSS, C89, C90, C91
C86, CSS, C89, C90,
C91
C40, CSS, C90, C91,
C99
C86, C90, C91
C86, CSS, C89, C90,
C91
FL C46, C86, C92, C98,
CA1 , GK6
C89, C90, C91
C46, C86, CSS, C90,
C91
C89, C90, C91
C46
C46
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 13
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
))))))))
PEPPER
Spray., Post-final harvest., Sprayer.
POTATO, WHITE/IRISH
Desiccation. Use Pesticide Type code "43"
Preharvest., Aircraft.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Use Group
(CI) A *
(CI) A *
Use Group
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
(CI) A *
NA *
: TERRESTRIAL
NS
NS
NS
NS
: TERRESTRIAL
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1/1
1/1
1/1
1/1
1/1
1/1
1/1
1/1
1/1
1/1
1/1
1/1
1/1
yr
yr
yr
yr
yr
yr
yr
yr
yr
yr
yr
yr
yr
NS
FOOD CROP
NS
NS
FOOD+FEED
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
NS
NS
NS
NS
NS
NS NS
NS NS
CROP
NS NS
NS NS
NS NS
NS NS
NS NS
NS NS
NS NS
NS NS
NS NS
. 5 Ib NS
(CI)
. 5 Ib NS
(CI)
. 5 Ib NS
(CI)
. 5 Ib NS
(CI)
NS NS
NS FL
NS FL
NS ID
NS MN
NS MT
NS ND
NS NE
NS NV
NS OR
NS WA
NS WI
NS MN
NS MT
NS NV
NS OR
NS ND
C46
C46, HOI(7)
C46, HOI(7)
C46, HOI(7)
C46, HOI(7)
C46, HOI(7)
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 14
Max. Appl . Soil Max. tt Apps Max. Dose [ (AI Min. Restr. Geographic Limitations
Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed
SITE Application Type, Application Form(s) Min. Appl.
Timing, Application Equipment ) Rate (AI un-
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv
cy Influencing Factor (Antimicrobial only) otherwise)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
Use
Limitations
Codes
POTATO, WHITE/IRISH (con't)
Desiccation. Use Pesticide Type code "43"
Preharvest., Ground.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
otherwise) Dose cycle
))))))))))))))))))))))))))))))))))))
Use Group: TERRESTRIAL
.25 Ib (CI) A * 3 NS
.25 Ib (CI) A * NS NS
.5 Ib (CI) -- * NS NS
.25 Ib (CI) A * NS NS
.25 Ib (CI) A * NS NS
.5 Ib (CI) -- * NS NS
.5 Ib (CI) -- * NS NS
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
/crop /year [day(s)]
cycle
)))))))))))
FOOD+FEED
.75 Ib
(CI)
.75 Ib
(CI)
.75 Ib
(CI)
NS
NS
NS
NS
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
.5 Ib
(CI)
))))))))))))))))))))))))»:
CROP (con't)
NS 5 NS ME
NS 5 NS ME
NS 5 NS MI
NS 5 7
NS 5 NS
NS 5 NS ME
NS 5 NS MI
NS NS NS ID
NS NS NS MN
NS NS NS MT
NS NS NS ND
NS NS NS NE
NS NS NS NV
NS NS NS OR
NS NS NS WA
NS NS NS WI
C46, GK6
C46, HOI(7)
C46, C89, C90, C91,
C92
C46, C86, C92, C98,
CA1, GK6, HOI(7)
C46, GK6, HOI(7)
C46, HOI(7)
C46
C46
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 15
Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations
Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed
SITE Application Type, Application Form(s) Min. Appl.
Timing, Application Equipment ) Rate (AI un-
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv
cy Influencing Factor (Antimicrobial only) otherwise)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
Use
Limitations
Codes
POTATO, WHITE/IRISH (con't)
Desiccation. Use Pesticide Type code "43"
Preharvest., Sprayer.
Spray., Preemergence., Sprayer.
Spray., Preplant., Sprayer.
RADISH
Desiccation. Use Pesticide Type code "43"
Preharvest., Aircraft.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
otherwise) Dose cycle /crop /year
cycle
))))))))))))))))))))))))))))))))))))
Use Group: TERRESTRIAL
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
.5 Ib (CI) A * 1 1/1 yr
NA * 1 NS
.25 Ib (CI) A * 3 NS
.25 Ib (CI) A * 3 NS
.5 Ib (CI) -- * NS NS
.25 Ib (CI) A * NS NS
.25 Ib (CI) A * NS NS
.5 Ib (CI) -- * NS NS
.5 Ib (CI) -- * NS NS
* 1 1/1 yr
.25 Ib (CI) A * NS NS
.25 Ib (CI) A * NS NS
Use Group: TERRESTRIAL
.5 Ib (CI) A * NS NS
))))))))))))
FOOD+FEED
NS
NS
NS
NS
NS
.75 Ib
(CI)
.75 Ib
(CI)
.75 Ib
(CI)
NS
NS
NS
NS
NS
NS
NS
FOOD CROP
NS
[day(s) ]
)))))))))))))))))))))))»:
CROP (con't)
. 5 Ib NS
(CI)
. 5 Ib NS
(CI)
. 5 Ib NS
(CI)
. 5 Ib NS
(CI)
NS NS
NS 5
NS 5
NS 5
NS 5
NS 5
NS 5
NS 5
. 5 Ib NS
(CI)
NS NS
NS NS
NS NS
NS MN
NS MT
NS NV
NS OR
NS ND
NS ME
NS ME
NS MI
7
NS
NS ME
NS MI
NS OR
NS ME
NS ME
NS WA
C46, H01(7)
C46, H01(7)
C46, H01(7)
C46, H01(7)
C46, H01(7)
C46, GK6
C46, H01(7)
C46, C89, C90, C91,
C92
C46, C86, C92, C98,
CA1, GK6, HOI(7)
C46, GK6, HOI(7)
C46, H01(7)
C46, H01(7)
C46
C46
C14, C46, GI7,
H01(3)
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 16
SITE Application Type, Application Form(s) Min. Appl.
Timing, Application Equipment ) Rate (AI un-
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv
cy Influencing Factor (Antimicrobial only) otherwise)
Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations
Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed
otherwise) Dose cycle
/crop
cycle
/year
[day(s) ]
Use
Limitations
Codes
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
SORGHUM
Desiccation. Use Pesticide Type code "43"
Seed crop., Aircraft.
Desiccation. Use Pesticide Type code "43"
Seed crop., Ground.
SOYBEANS (UNSPECIFIED)
Desiccation. Use Pesticide Type code "43"
Seed crop., Aircraft.
Desiccation. Use Pesticide Type code "43"
Seed crop., Ground.
SQUASH (ALL OR UNSPECIFIED)
Spray., Post-final harvest., Sprayer.
STORAGE AREAS-EMPTY
Spot treatment., When needed., Sprayer.
Spray., When needed., Sprayer.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
Use Group: TERRESTRIAL FOOD+FEED CROP
.5 Ib (CI) A * NS NS NS NS NS 7
.5 Ib (CI) A * NS NS NS NS NS NS
.5 Ib (CI) A * NS NS NS NS NS 7
.5 Ib (CI) A * NS NS NS NS NS NS
Use Group: TERRESTRIAL FOOD+FEED CROP
.5 Ib (CI) A * NS NS NS NS NS 1
.5 Ib (CI) A * NS NS NS NS NS 7
.5 Ib (CI) A * NS NS NS
.5 Ib (CI) A * NS NS NS
Use Group: TERRESTRIAL FOOD CROP
.5 Ib (CI) A * NS
.5 Ib (CI) A * NS
Use Group: IN
.01038 Ib (CI) -- * NS
.013 Ib (CI) -- * NS
.013 Ib (CI) -- * NS
.01038 Ib (CI) -- * NS
NS NS 1
NS
NS
)R FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
NS
NS
1
1
1
1
FL
FL
C14, C46, C89, C90,
C91, C92
C14, C46, C86, C92,
C98, CA1, G88, GK6,
GL5, HOI(14)
C14, C46, C89, C90,
C91, C92
C14, C46, C86, C92,
C98, CA1, G88, GK6,
GL5, HOI(14)
C14, C46, C86, C92,
C98, CA1, G88, GK6,
GL5, HOI(7)
C14, C46, C89, C90,
C91, C92, G88, GI7
C14, C46, C86, C92,
C98, CA1, G88, GK6,
GL5, HOI(7)
C14, C46, C89, C90,
C91, C92, G88, GI7
C86, CSS, C89, C90,
C91
C86, C90, C91
CAE
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 17
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
FOOD/FEED USES (con't)
))))))))))))))))))))))))»:
STORAGE AREAS-EMPTY (con't)
STORAGE AREAS-FULL
Spot treatment., When needed., Sprayer.
Spray., When needed., Sprayer.
TOMATO
Spray., Post-final harvest., Sprayer.
Desiccation. Use Pesticide Type code "43"
Preharvest., Aircraft.
NON-FOOD/NON-FEED
Use Group: INDOOR FOOD (con't)
SC/L
SC/L
NA
NA
.01016 Ib (CI)
UC *
*
Use Group
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
.01038 Ib (CI)
.013 Ib (CI)
.013 Ib (CI)
.01038 Ib (CI)
.01016 Ib (CI)
*
*
__ *
__ *
UC *
*
Use Group
SC/L
SC/L
SC/L
NA
NA
NA
.375 Ib (CI)
.375 Ib (CI)
.375 Ib (CI)
A *
A *
A *
Use Group
SC/L
NA
.5 Ib (CI)
A *
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
NS
NS
C86, CSS, C89, C90,
C91
C92
: INDOOR FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
FOOD+FEED
NS
NS
NS
FOOD CROP
NS
NS
NS
NS
NS
NS
NS
CROP
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
NS
NS
NS
NS
1
1
1
1
NS
NS
NS FL
NS GA
NS PR
NS WA
CAE
C86, CSS, C89, C90,
C91
C86, C90, C91
CAE
C86, CSS, C89, C90,
C91
C92
C46
C46
C46
C14, C46, GI7,
HOI (3)
AGRICULTURAL FALLOW/IDLELAND
Spray., When needed., Sprayer.
SC/L NA
SC/L NA
Use Group: TERRESTRIAL NON-FOOD CROP
.01042 Ib (CI) * NS NS NS NS AN
.01042 Ib (CI) --
NS NS
NS
NS AN
C86, CSS, C89, C90,
C91
C46, C86, C92, C98,
CA1, GK6
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 18
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
AGRICULTURAL FALLOW/IDLELAND (con't)
AGRICULTURAL RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS
Spray., When needed., Sprayer.
AGRICULTURAL UNCULTIVATED AREAS
Spray., When needed., Sprayer.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
IS
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
1 Ib
.02031 Ib
1 Ib
.01016 Ib
.01042 Ib
.01042 Ib
1 Ib
.02031 Ib
1 Ib
.01042 Ib
.01042 Ib
.5 Ib
.01042 Ib
.01042 Ib
.01042 Ib
Use Group
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
Use Group
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
Use Group
(CI) -- *
(CI) -- *
(CI) -- *
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NON -FOOD
NS
NS
NS
NS
NON -FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NON -FOOD
NS
NS
NS
CROP (con't)
NS AN
NS AN
NS AN
NS AN
CROP
NS AN
NS AN
NS AN
NS AN
NS AN
NS AN
NS AN
NS AN
CROP
NS AN
NS AN
NS AN
NS
NS
NS
NS
1
NS
NS
NS
NS
NS
NS
NS
1
1
NS
C46, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91, CAE
C86, C89, C90, C91,
C92
C86,
C91
C46,
CA1,
C46,
C92
C86,
C91
C86,
C91,
C86,
C92
CSS,
CSS,
CSS, C89, C90,
C86, C92, C98,
GK6
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91,
C89, C90, C91
C90, C91
C86, CSS, C89, C90,
C91
CSS, C89, C90, C91
C46, C86, C92, C98,
CA1, GK6
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 19
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
AGRICULTURAL UNCULTIVATED AREAS (con't)
SC/L NA
SC/L NA
SC/L NA
SC/L NA
AGRICULTURAL/FARM STRUCTURES/BUILDINGS AND EQUIPMENT
Spray., When needed., Sprayer. SC/L NA
AIRPORTS/LANDING FIELDS
Edging treatment., When needed., Sprayer. RTU NA
Spot treatment., When needed., Sprayer. RTU NA
AQUATIC AREAS/WATER
Water treatment (subsurface)., When needed., SC/L NA
Injection.
Water treatment (surface)., When needed., SC/L NA
Boat.
COMMERCIAL/INDUSTRIAL LAWNS
Directed spray., When needed., Trigger spray RTU NA
bottle.
Spray., When needed., Sprayer. RTU NA
Sprinkle., When needed., Sprinkler can. RTU NA
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (OUTDOOR)
Directed spray., When needed., Trigger spray RTU NA
bottle.
Use Group: TERRESTRIAL NON-FOOD CROP (con't)
1 Ib (CI) * NS NS NS NS AN
.02031 Ib (CI) -- * NS NS
1 Ib (CI) -- * NS NS
.01042 Ib (CI) -- * NS NS
NS NS AN
NS NS AN
NS NS AN
Use Group: TERRESTRIAL NON-FOOD CROP
.01042 Ib (CI) * NS NS NS NS AN
Use Group: TERRESTRIAL NON-FOOD CROP
UC * NS NS NS NS AN
UC * NS NS NS NS AN
Use Group: AQUATIC NON-FOOD OUTDOOR
4 Ib (CI) A * NS NS NS NS AN
4 Ib (CI) A * NS NS
NS NS AN
Use Group: TERRESTRIAL NON-FOOD CROP
UC * NS NS NS NS AN
UC * NS NS NS NS AN
UC * NS NS NS NS AN
Use Group: TERRESTRIAL NON-FOOD CROP
UC * NS NS NS NS AN
NS
NS
NS
NS
C46, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91, CAE
C86, C89, C90, C91,
C92
C46, C86, C92, C98,
CA1, GK6
CSV
CSV
CSS, C90, C91
CSS, C90, C91
CAG
CAG
CAG
UC
* NS
NS
NS
NS AN
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 20
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
COMMERCIAL/INSTITUTIONAL/INDUSTRIAL PREMISES/EQUIPMENT (OUTDOOR) (con'
Spray., When needed., Sprayer. RTU NA
Spray., When needed., Trigger spray bottle. RTU NA
Sprinkle., When needed., Sprayer. RTU NA
Sprinkle., When needed., Sprinkler can. RTU NA
Directed spray., When needed., Trigger spray RTU
bottle.
Use Group: TERRESTRIAL NON-FOOD CROP (con't)
UC * NS NS NS NS AN NS
UC * NS NS NS NS NS NS
UC * NS NS NS NS NS NS
UC * NS NS NS NS AN NS
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL
UC
NS
NS
NS
NS
CAG
CAE, CAG, G74
CAE, CAG, G74
CAG
DRAINAGE SYSTEMS
Aquatic deep water injection/bottom
placement application., Spring., Weighted
trailing hose.
Aquatic deep water injection/bottom
placement application., Summer., Weighted
trailing hose.
Aquatic deep water injection/bottom
placement application., When needed.,
Weighted trailing hose.
Aquatic subsurface injection application.
When needed., Trailing hose.
Edging treatment., Prebloom., Sprayer.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
Use Group: AQUATIC NON-FOOD INDUSTRIAL
4 Ib (CI) A * NS NS NS NS
4 Ib (CI) A * NS NS NS NS
4 Ib (CI) A * NS NS NS NS
4 Ib (CI) A * NS NS NS NS
4 Ib (CI) A * NS NS NS NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
2 Ib (CI) A * NS NS
2 Ib (CI) A * NS NS
NS
NS
NS
NS
NS
NS NS
NS AN
NS NS
NS AN
NS NS
NS FL
NS
NS FL
NS FL
NS
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C46, C86, C92, C98,
CA1, GK6
C89, C90, C91
C46, C86, C92, C98,
CA1, GK6
C89, C90, C91
C89, C90, C91
C86, CSS, C89, C90,
C91, CAE
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 21
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
DRAINAGE SYSTEMS (con't)
Pour-on., When needed., Boat.
Shoreline treatment., Prebloom., Sprayer.
Use Group: AQUATIC NON-FOOD INDUSTRIAL (con't)
SC/L NA
4 Ib (CI) A
Shoreline treatment., When needed., Sprayer. RTU
Spot treatment., When needed., Sprayer.
Spray., Foliar., Sprayer.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
RTU
RTU
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
2 Ib
1.66 Ib
2 Ib
2.16 Ib
2 Ib
.01042 Ib
.02031 Ib
2 Ib
1.92 Ib
1.5 Ib
1.245 Ib
1.5 Ib
1.5 Ib
1.245 Ib
(CI) --
(CI) --
(CD --
(CD --
(CD --
uc
(CI) --
(CI) --
(CI) --
(CI) --
uc
uc
(CI) A
(CI) A
UC
UC
(CI) A
(CI) A
UC
(CI) A
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
*
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
NS
AN
AN
AN
AN
AN
NS
NS
NS
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
1
NS
1
1
NS
C46, C86, C92, C98,
CA1, GK6
C86, CSS, C90, C91
C86, C90, C91
C86, CSS, C89, C90,
C91
C86, C89, C90, C91
C86, C89, C90, C91,
C92
CSS, C89, C90, C91
C86,
C91
C40,
C99
C46,
C91
CSV
CSV
C86,
C86,
CSS,
C86,
C91
C86,
C86,
C91
CSS, C89, C90,
CSS, C90, C91,
C86, CSS, C90,
CSS, C90, C91
C90, C91
C89, C90, C91
CSS, C89, C90,
C90, C91
CSS, C89, C90,
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 22
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
DRAINAGE SYSTEMS (con't)
Water application., Foliar., Sprayer.
Water application., When needed., Boat.
Water treatment (subsurface)., When needed., SC/L NA
Boat.
Use Group: AQUATIC NON-FOOD INDUSTRIAL
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
2 Ib (CI) --
.01563 Ib (CI) --
1.66 Ib (CI) --
UC
UC
4 Ib (CI) A
UC
3.486 Ib (CI)
A-ft
4 Ib (CI) A
2.16 Ib (CI) A
4 Ib (CI) A
4 Ib (CI) A
3.984 Ib (CI)
A-ft
4.2 Ib (CI) A-ft
UC
4.2 Ib (CI) A-ft
4 Ib (CI) A
4 Ib (CI) A-ft
3.32 Ib (CI) A
UC
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
*
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
(con' t)
AN
AN
NS
NS
14
AN
AN
AN
AN
AN
AN
NS
14
AN
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
1
1
1
NS
FL
FL
FL
C86, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C90, C91, CAE
C90, C91, CAE
C46, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91, CAE
C86, C89, C90, C91
C86, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
CSS, C89, C90, C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 23
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
DRAINAGE SYSTEMS (con't)
Water treatment (subsurface)., When needed., SC/L NA
Injection.
Use Group: AQUATIC NON-FOOD INDUSTRIAL (con't)
4.2 Ib (CI) A-ft
C86, C90, C91
Water treatment (surface)., Spring.,
Sprayer.
Water treatment (surface)., Summer.,
Sprayer.
Water treatment (surface)., When needed.,
Aircraft.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
UC
UC
4.2 Ib (CI) A-ft
4 Ib (CI)
A
4 Ib (CI) A-ft
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
UC
UC
A
UC
A
A
3.984 Ib (CI)
A-ft
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
1.5 Ib (CI)
A
A
A
A
A
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
14
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
NS
NS
NS
NS
AN
NS
1
1
1
NS
NS
NS
NS
NS
NS
NS
NS AL
NS TN
NS AL
NS TN
NS
C90,
C86,
C91
C86,
CSS,
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
C86,
C91
C86,
C91, CAE
CSS, C89,
CSS, C90,
C89, C90,
C89, C90,
C90,
C91
C91
C91,
CSS, C89, C90,
CSS, C89,
CAE
C89, C90,
C89, C90,
CSS, C89,
CSS, C90,
C90,
C91
C91,
C90,
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C46, C86, C92, C98,
CA1, GK6
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 24
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
DRAINAGE SYSTEMS (con't)
SC/L NA
Water treatment (surface)., When needed., SC/L NA
Boat.
SC/L NA
SC/L NA
Water treatment (surface)., When needed., SC/L NA
Boom sprayer.
Water treatment (surface)., When needed., SC/L NA
Injection.
SC/L NA
Water treatment (surface)., When needed., SC/L NA
Sprayer.
SC/L NA
Water treatment., When needed., Helicopter. SC/L NA
FENCEROWS /HEDGEROWS
Directed spray., When needed., Sprayer. SC/L NA
SC/L NA
Directed spray., When needed., Trigger spray SC/L NA
bottle.
Edging treatment., When needed., Sprayer. SC/L NA
Use Group
1.5 Ib (CI) A *
4.2 Ib (CI) A-ft *
4.2 Ib (CI) A-ft * NS NS
4 Ib (CI) A-ft * NS NS
4 Ib (CI) -- * NS NS
4.2 Ib (CI) A-ft * NS NS
4.2 Ib (CI) A-ft * NS NS
4 Ib (CI) A * NS NS
AQUATIC NON-FOOD INDUSTRIAL (con't)
NS NS NS NS NS NS FL
NS NS NS NS 14 1
4 Ib (CI) A *
20 Ib (CI) -- *
Use Group
.01038 Ib (CI) -- *
.01016 Ib (CI) -- *
.004215 Ib (CI) *
.005078 Ib (CI)
NS
NS
NS
NS
NS AN
NS 14
NS AN
1
NS AN 1
NS AN NS NY
1
NS
NS NS NS NS AN NS FL
NS NS NS NS NS NS FL
TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL
NS NS NS NS AN 1
NS NS NS NS AN NS
NS NS NS NS AN 1
NS NS
NS
NS AN
1
C89, C90, C91
C86, C90, C91
C86, CSS, C89, C90,
C91
CSS, C89, C90, C91
C40, CSS, C90, C91,
C99
C86, C90, C91
C86, CSS, C89, C90,
C91
C46, C86, C92, C98,
CA1, GK6
C89, C90, C91
C89, C90, C91
CAE
C92
C46, C86, CSS, C90,
C91, GA4
C86, CSS, C90, C91
Spot treatment., When needed., Sprayer. SC/L NA
SC/L NA
.01038 Ib (CI) --
UC
NS NS
NS NS
NS
NS
NS AN 1
NS AN NS
C86, CSS, C89, C90,
C91
SC/L NA
.01016 Ib (CI) -- * NS NS
NS AN
NS
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 25
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
FENCEROWS/HEDGEROWS (con't)
Spray., When needed., Sprayer.
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
GOLF COURSE TURF
Broadcast., Dormant., Ground.
Desiccation. Use Pesticide Type code "43"
Pre-renovation, Ground.
Golf course treatment., When needed.,
Sprayer.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.013
.01016
.013
.01042
.008
1
.54
2
.5
.5
.5
.5
.5
.5
1
.013
.01016
.013
.01042
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
UC *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
Use Group
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NON -FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
CROP
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
1
1
1
NS
NS
NS
NS
NS
NS AR
NS LA
NS MS
NS OK
NS OK
NS TN
NS CA
1
1
1
1
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
C46, C86, C92, C98,
CA1 , GK6
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91, CAE
C86, C89, C90, C91
C46, C86, CSS, C90,
C91
C46
C46
C46
C46
C46
C46, G68
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
CSS, C89, C90, C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 26
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
GOLF COURSE TURF (con't)
Spot treatment., When needed., Sprayer.
GREENHOUSE-EMPTY
Indoor premise treatment., When needed.
Sprayer.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.5
.01038
.01894
.892
.01042
1
.008
1
.54
.01042
.013
.01016
.01038
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
.004215
.013
.013
.01038
Ib
Ib
Ib
Use Group
(CI) -- *
(CI) -- *
(CI) -- *
(CI) A *
(CI) -- *
(CI) -- *
UC *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
UC *
(CI) -- *
(CI) -- *
Ib (CI) *
Use Group
UC *
(CI) -- *
(CI) -- *
(CI) -- *
: TERRESTRIAL NON- FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
CROP (con't)
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
AN
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
: INDOOR NON- FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
1
1
1
CSS, C90, C91
CAE
C46,
C91,
C46,
CA1,
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
CSS,
C90,
C92
C86,
C46,
C91,
C86, CSS, C90,
GA4
C86, C92, C98,
GK6
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91
C89, C90, C91,
C89, C90, C91
C91, CAE
CSS, C90, C91
C86, CSS, C90,
GA4
C86, CSS, C89, C90,
C91
C86, C90, C91
CAE
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 27
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
GREENHOUSE-EMPTY (con't)
Indoor premise treatment., When needed.,
Trigger spray bottle.
Spray., When needed., Sprayer.
Use Group: INDOOR NON- FOOD (con'
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.01894
.01042
.01042
1
.01042
.013
.5
.01016
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
.009727
.01016
Ib
.004215
(CI) --
(CI) --
UC
(CD --
(CD --
(CD --
(CD --
(CD --
uc
(CD --
Ib (CD
(CD --
lb (CD
* NS
* NS
* NS
*
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
t)
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
1
1
C46,
CA1,
C86,
C91
C86,
C91,
C86,
C92
CSS,
CSS,
C90,
C92
C46,
C91,
C86,
C86,
C86, C92, C98,
GK6
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91,
C89, C90, C91
C90, C91
C91, CAE
C86, CSS, C90,
GA4
CSS, C90, C91
C90, C91
SC/L NA
1 lb (CI) --
HOUSEHOLD/DOMESTIC DWELLINGS OUTDOOR PREMISES
Directed spray., When needed., Sprayer.
Directed spray., When needed., Sprinkler
can.
Use Group: OUTDOOR RESIDENTIAL
RTU
SC/L
SC/L
RTU
NA
NA
NA
NA
.05
.01038
.01016
lb
lb
lb
(CI)
sq
(CI)
(CI)
IK
.ft
--
--
UC
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
NS
NS
1
NS
NS
C46, C89, C90, C91,
C92
CAE, CAG
CAE
C92
CAE, CAG, GLS
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
HOUSEHOLD/DOMESTIC DWELLINGS OUTDOOR PREMISES (con't)
Directed spray., When needed., Squeeze RTU NA
applicator.
Directed spray., When needed., Tank.
Directed spray., When needed., Trigger spray RTU NA
bottle.
Use Group: OUTDOOR RESIDENTIAL (con't)
UC * NS NS NS NS NS
Edging treatment., When needed., Sprayer.
Spot treatment., When needed., Sprayer.
Spot treatment., When needed., Sprinkler
can.
Spray., When needed., Hose-end sprayer.
Spray., When needed., Sprayer.
Spray., When needed., Sprinkler can.
SC/L
RTU
RTU
RTU
SC/L
RTU
RTU
SC/L
RTU
RTU
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.05 Ib (CI)
sq
.02 Ib (CI)
sq
.05 Ib (CI)
sq
.01038 Ib (CI)
.01016 Ib (CI)
.02 Ib (CI)
sq
UC
UC
UC
UC
UC
UC
IK
.ft
IK
.ft
UC
IK
.ft
--
UC
IK
.ft
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
NS
AN
NS
NS
AN
NS
AN
AN
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
NS
NS
SC/L
RTU
SC/L
SC/L
NA
NA
NA
NA
UC
UC
UC
UC
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
NS
NS
NS
NS
NS
CAE, CAG, GL8
C92
CAE
CAG
CSV
CAE, CAG
CSV
CAE, CAG
CAE
C92
CAE, CAG, GLS
C92
CAG
C92
CAE
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 29
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
HOUSEHOLD/DOMESTIC DWELLINGS OUTDOOR PREMISES (con't)
Spray., When needed., Tank-type sprayer.
Spray., When needed., Trigger spray bottle. RTU
Sprinkle., When needed., Sprayer.
Sprinkle., When needed., Sprinkler can.
INDUSTRIAL AREAS (OUTDOOR)
Edging treatment., When needed., Sprayer.
Spot treatment., When needed., Sprayer.
Spray., When needed., Sprayer.
Use Group: OUTDOOR RESIDENTIAL (con't)
INTERMITTENTLY FLOODED AREAS/WATER
Edging treatment., Prebloom., Sprayer.
Spray., Foliar., Sprayer.
SC/L
SC/L
RTU
SC/L
RTU
RTU
SC/L
NA
NA
NA
NA
NA
NA
NA
UC * NS
UC * NS
UC * NS
.004215 Ib (CI) * NS
UC * NS
UC * NS
UC * NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
Use Group: TERRESTRIAL NON- FOOD
RTU
RTU
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
UC * NS
UC * NS
.01042 Ib (CI) -- * NS
.01042 Ib (CI) -- * NS
1 Ib (CI) -- * NS
UC * NS
.008 Ib (CI) -- *
1 Ib (CI) -- * NS
.01042 Ib (CI) -- * NS
.01038 Ib (CI) -- * NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
Use Group: AQUATIC
SC/L
SC/L
NA
NA
UC * NS
UC * NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
CROP
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
NS
NS
AN
NS
AN
NS
AN
AN
AN
AN
AN
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
NS
NS
NS
NS
NS
NS
NON -FOOD OUTDOOR
NS
NS
NS
NS
AN
AN
NS
NS
C92
CAE
CAE, CAG, G74
C46, C86, CSS, C90,
C91, GA4
CAE, CAG, G74
CAG
CSV
CSV
C86,
C91
C46,
CA1,
C46,
C92
C86,
C91
C86,
C91,
C86,
C92
C86,
CSS, C89, C90,
C86, C92, C98,
GK6
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91,
CSS, C90, C91
CSS, C89, C90, C91
CSS, C89, C90, C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 30
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
INTERMITTENTLY FLOODED AREAS/WATER (con't)
Water treatment (subsurface)., When needed., SC/L NA
Boat.
LAKES/PONDS/RESERVOIRS (WITHOUT HUMAN OR WILDLIFE USE)
Aquatic deep water injection/bottom SC/L NA
placement application., Spring., Weighted
trailing hose.
SC/L NA
Aquatic deep water injection/bottom SC/L NA
placement application., Summer., Weighted
trailing hose.
SC/L NA
Aquatic deep water injection/bottom SC/L NA
placement application., When needed.,
Weighted trailing hose.
SC/L NA
Aquatic subsurface injection application., SC/L NA
When needed., Trailing hose.
Edging treatment., Prebloom., Sprayer.
Pour-on., When needed., Boat.
Shoreline treatment., Prebloom., Sprayer.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
Use Group: AQUATIC NON-FOOD OUTDOOR (con't)
UC * NS NS NS NS AN NS
Use Group: AQUATIC NON-FOOD INDUSTRIAL
4 Ib (CI) A * NS NS NS NS NS NS
4 Ib (CI) A * NS NS NS NS NS NS
4 Ib (CI) A * NS NS NS NS NS NS
4 Ib (CI) A * NS NS NS NS NS NS
4 Ib (CI) A * NS NS NS NS AN NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
UC * NS NS
2 Ib (CI) A * NS NS
2 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
2 Ib (CI) -- * NS NS
1.66 Ib (CI) -- * NS NS
2 Ib (CI) A * NS NS
CSS, C89, C90, C91
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C46, C86, C92, C98,
CA1, GK6
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
NS
AN
AN
NS
AN
AN
AN
AN
NS FL
NS
NS FL
NS
NS FL
NS
NS
1
1
NS
C89,
FL C46,
CA1,
C89,
CSS,
C89,
C86,
C91,
FL C46,
CA1,
C86,
C86,
C86,
C91
C90,
C86,
GK6
C90,
C89,
C90,
CSS,
CAE
C86,
GK6
CSS,
C90,
CSS,
C91
C92, C98,
C91
C90, C91
C91
C89, C90,
C92, C98,
C90, C91
C91
C89, C90,
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 31
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
LAKES/PONDS/RESERVOIRS (WITHOUT HUMAN OR WILDLIFE USE) (con't)
Use Group: AQUATIC NON-FOOD INDUSTRIAL (con't)
Spray., Foliar., Sprayer.
Water application., Foliar., Sprayer.
Water application., When needed., Boat.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
2.16 Ib
2 Ib
.01042 Ib
.02031 Ib
2 Ib
1.92 Ib
1.5 Ib
1.245 Ib
1.5 Ib
1.5 Ib
1.245 Ib
2 Ib
.01563 Ib
1.66 Ib
4 Ib
(CI) --
(CI) --
(CD --
(CD --
(CD --
(CI) --
(CI) A
(CI) A
uc
uc
(CI) A
(CI) A
UC
(CI) A
(ci) --
(CI) --
(CI) --
uc
uc
(CI) A
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
*
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
NS
AN
AN
AN
NS
NS
NS
AN
AN
NS
NS
14
AN
NS
NS
NS
NS
NS NY
NS
1
1
NS
1
1
NS
NS
NS
NS
NS
NS
NS
C86,
C86,
C92
CSS,
FL C86,
C91
C40,
C99
C46,
C91
C86,
C86,
CSS,
C86,
C91
C86,
C86,
C91
C86,
C92
FL C86,
C91
FL C86,
FL C90,
FL C90,
C46,
C92
C89,
C89,
C89,
CSS,
CSS,
C86,
CSS,
C90,
C89,
CSS,
C90,
CSS,
C89,
CSS,
CSS,
C91,
C91,
C89,
C90, C91
C90, C91,
C90, C91
C89, C90,
C90, C91,
CSS, C90,
C90, C91
C91
C90, C91
C89, C90,
C91
C89, C90,
C90, C91,
C89, C90,
C90, C91
CAE
CAE
C90, C91,
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 32
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
LAKES/PONDS/RESERVOIRS (WITHOUT HUMAN OR WILDLIFE USE) (con't)
SC/L NA
SC/L NA
Use Group: AQUATIC NON-FOOD INDUSTRIAL (con't)
Water treatment (subsurface)., When needed., SC/L NA
Boat.
Water treatment (subsurface)., When needed., SC/L NA
Injection.
UC
3.486 Ib (CI)
A-ft
4 Ib (CI) A
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
2.16 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
4 Ib (CI) A * NS NS
3.984 Ib (CI) * NS NS
A-ft
4.2 Ib (CI) A-ft * NS NS
UC * NS NS
4.2 Ib (CI) A-ft *
4 Ib (CI) A * NS NS
4 Ib (CI) A-ft *
3.32 Ib (CI) A * NS NS
UC * NS NS
4.2 Ib (CI) A-ft * NS NS
UC * NS NS
UC * NS NS
4.2 Ib (CI) A-ft *
4 Ib (CI) A * NS NS
4 Ib (CI) A-ft * NS NS
UC * NS NS
NS NS AN NS
NS NS AN NS
NS NS AN NS
NS NS NS NS
NS NS 14 1
NS NS AN 1
NS NS AN 1
NS NS AN 1
NS NS AN NS
NS NS 14 1
NS NS 14 NS
NS NS AN 1
NS NS AN 1
NS NS AN 1
NS NS AN NS
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91, CAE
C86, C89, C90, C91
C86, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
CSS, C89, C90, C91
C86, C90, C91
C90, C91, CAE
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
CSS, C89, C90, C91
C46, C89, C90, C91,
C92
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 33
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
LAKES/PONDS/RESERVOIRS (WITHOUT HUMAN OR WILDLIFE USE) (con't)
Use Group: AQUATIC NON-FOOD INDUSTRIAL (con't)
Water treatment (surface)., Spring.,
Sprayer.
Water treatment (surface)., Summer.,
Sprayer.
Water treatment (surface)., When needed.,
Aircraft.
Water treatment (surface)., When needed.,
Boat.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
4 Ib
4
4
4
UC
(CI) A-ft
Ib (CI) A
UC
Ib (CI) A
Ib (CI) A
3.984 Ib (CI)
A-ft
4
4
4
4
1.5
1.5
4.2 Ib
4.2 Ib
4 Ib
4 Ib
Ib (CI) A
Ib (CI) A
Ib (CI) A
Ib (CI) A
Ib (CI) A
Ib (CI) A
(CI) A-ft
(CI) A-ft
(CI) A-ft
(CI) A-ft
* NS
*
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
NS
NS
NS
NS
NS
AN
NS
14
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS AL
NS TN
NS AL
NS TN
NS
NS FL
1
1
1
NS
C86,
C91
C86,
C91,
C86,
C86,
C92
FL C86,
C91
FL C86,
C07,
C91,
C07,
C91,
C07,
C91,
C07,
C91,
FL C46,
CA1,
C89,
C86,
C86,
C91
CSS,
C86,
CSS,
CSS,
CAE
C89,
C89,
CSS,
CSS,
CSS,
CA1
CSS,
CA1
CSS,
CA1
CSS,
CA1
C86,
GK6
C90,
C90,
CSS,
C89,
CSS,
C89,
C89,
C90,
C90,
C89,
C90,
C89,
C89,
C89,
C89,
C92,
C91
C91
C89,
C90,
C89,
C90,
C90,
C91
C91,
C90,
C91
C90,
C90,
C90,
C90,
C98,
C90,
C91
C90,
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 34
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex.
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max.
cy Influencing Factor (Antimicrobial only) otherwise) otherwise) Dose
Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
@ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
/crop /year otherwise)/A] (days) Interv Codes
cycle /crop /year [day(s)]
cycle
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
LAKES/PONDS/RESERVOIRS (WITHOUT HUMAN OR WILDLIFE USE) (con't) Use Group
4 Ib (CI) -- *
Water treatment (surface)., When needed., SC/L NA
Boom sprayer.
Water treatment (surface)., When needed., SC/L NA
Injection.
SC/L NA
Water treatment (surface)., When needed., SC/L NA
Sprayer.
Water treatment., When needed., Helicopter. SC/L NA
NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES
Directed spray., When needed., Sprayer.
Directed spray., When needed., Sprinkler RTU NA
can.
Directed spray., When needed., Squeeze
applicator.
Edging treatment., When needed., Sprayer. RTU NA
SC/L NA
AQUATIC NON-FOOD INDUSTRIAL (con't)
NS NS NS NS AN NS NY
4.2 Ib (CI) A-ft * NS NS
4.2 Ib (CI) A-ft
4 Ib (CI) A * NS NS
NS
NS 14
1
C40, CSS, C90, C91,
C99
C86, C90, C91
C86, CSS, C89, C90,
C91
C46, C86, C92, C98,
CA1, GK6
SC/L
SC/L
SC/L
NA
NA
NA
4 Ib (CI)
20 Ib (CI)
20 Ib (CI)
A *
__ *
__ *
Use Group
RTU
SC/L
SC/L
SC/L
RTU
RTU
RTU
RTU
NA
NA
NA
NA
NA
NA
NA
NA
.05 Ib (CI)
sq.
IK *
ft
.009727 Ib (CI) *
.01038 Ib (CI)
.01016 Ib (CI)
.05 Ib (CI)
sq.
__ *
__ *
UC *
uc *
UC *
IK *
ft
NS
NS
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NON -FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
CROP
NS
NS
NS
NS
NS
NS
NS
NS
AN
NS
NS
NS
AN
AN
AN
NS
NS
AN
NS
NS FL
NS FL
NS FL
NS
1
1
NS
NS
NS
NS
NS
C89, C90, C91
C46
C89, C90, C91
CAE, CAG
C46, C86, CSS, C90,
C91, GA4
CAE
C92
CAE, CAG, GLS
CAE, CAG, GLS
C87
CAE, CAG
.005078 Ib (CI) * NS NS
C86, CSS, C90, C91
Spot treatment., When needed., Sprayer.
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 35
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES (con't)
Use Group: TERRESTRIAL NON-FOOD CROP (con't)
Spray., When needed., Hose-end sprayer.
Spray., When needed., Sprayer.
RTU
RTU
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.05
.01038
.01016
.013
.01016
.013
.01042
.5
.01894
.01042
1
.008
1
.54
.01042
.013
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
(CI) IK
sq.ft
UC
(CI) --
UC
(CD --
UC
(CD --
(CD --
(CD --
(CD --
(CD --
(CD --
(CD --
(CD --
UC
(CI) --
(CI) --
(CI) --
(CI) --
(CI) --
UC
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
NS
1
NS
NS
1
1
1
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
CAE, CAG
CAE, CAG, GL8
CAE
C92
C92
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
CSS, C89, C90, C91
CSS, C90, C91
C46,
CA1,
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
CSS,
C90,
C86, C92, C98,
GK6
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91
C89, C90, C91,
C89, C90, C91
C91, CAE
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 36
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES (con't)
SC/L NA
Spray., When needed., Sprinkler can. SC/L NA
SC/L NA
Spray., When needed., Tank-type sprayer. SC/L NA
SC/L NA
Use Group: TERRESTRIAL NON-FOOD CROP (con't)
Spray., When needed., Sprayer.
SC/L NA
NONAGRICULTURAL RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS
Spray., When needed., Sprayer.
Directed spray., When needed., Sprayer.
Directed spray., When needed., Tank.
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
01038 Ib
(CI) -- * NS
UC * NS
UC * NS
UC * NS
UC * NS
NS
NS
NS
NS
NS
Use Group: TERRESTRIAL
UC * NS
NS
Use Group: TERRESTRIAL
01042 Ib
01042 Ib
1 Ib
.008 Ib
1 Ib
01042 Ib
(CI) -- * NS
(CI) -- * NS
(CI) -- * NS
UC * NS
(CI) -- *
(CI) -- * NS
(CI) -- * NS
NS
NS
NS
NS
NS
NS
Use Group: TERRESTRIAL
.009727
Ib (CI) * NS
NS
NS
NS
NS
NS
NS
NON -FOOD -
NS
NON -FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
nOUTDOOR
NS
CROP
NS
NS
NS
NS
NS
NS
NS
AN
NS
AN
NS
RESII
AN
AN
AN
AN
AN
AN
AN
NS
NS
NS
NS
NS
)ENTi;
NS
1
NS
NS
NS
NS
NS
NON-FOOD+OUTDOOR RESIDENT!;
NS
NS
AN
1
Directed spray., When needed., Trigger spray SC/L NA
bottle.
UC
UC
NS NS
NS NS
NS
NS
NS NS NS
NS NS NS
C86, CSS, C90, C91
C92
CAE
C92
CAE
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91
C46, C86, C92, C98,
CA1, GK6
C46, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91, CAE
C86, C89, C90, C91,
C92
C46, C86, CSS, C90,
C91, GA4
Edging treatment., When needed., Sprayer. RTU NA
NS NS
NS AN
NS
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 37
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
NONAGRICULTURAL RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS (con't)
Spot treatment., When needed., Sprayer.
Spray., When needed., Sprayer.
Spray., When needed., Trigger spray bottle. RTU
Sprinkle., When needed., Sprayer.
Sprinkle., When needed., Sprinkler can.
NONAGRICULTURAL UNCULTIVATED AREAS/SOILS
Directed spray., When needed., Sprinkler
can.
Directed spray., When needed., Squeeze
applicator.
Edging treatment., When needed., Sprayer.
Spot treatment., When needed., Sprayer.
Spot treatment., When needed., Sprinkler
can.
Spray., When needed., Sprayer.
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
RTU
SC/L
SC/L
SC/L
SC/L
SC/L
RTU
RTU
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
UC * NS
.01894 Ib (CI) -- * NS
.01042 Ib (CI) -- * NS
.5 Ib (CI) -- * NS
UC * NS
.01038 Ib (CI) -- * NS
UC * NS
UC * NS
UC * NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
Use Group: TERRESTRIAL
RTU
RTU
RTU
SC/L
RTU
RTU
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
UC * NS
UC * NS
UC * NS
.005078 Ib (CI) * NS
UC * NS
UC * NS
.013 Ib (CI) -- * NS
.01016 Ib (CI) -- * NS
.013 Ib (CI) -- * NS
.01042 Ib (CI) -- * NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NON -FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
CROP
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
NS
NS
NS
NS
NS
NS
AN
AN
AN
NS
AN
AN
AN
AN
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
NS
NS
1
1
1
NS
CSS, C89, C90, C91
CSS, C90, C91
C90, C91, CAE
C86, CSS, C90, C91
CAE, CAG, G74
CAE, CAG, G74
CAE, CAG, GLS
CAE, CAG, GLS
C87
C86, CSS, C90, C91
C87
CAE, CAG, GLS
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
C46, C86, C92, C98,
CA1, GK6
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 38
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
))))))))))))))))))))))))))))))
NONAGRICULTURAL UNCULTIVATED AREAS/SOILS (con't)
NONAGRICUTURAL UNCULTIVATED SOIL STERILIZATION
Spray., When needed., Sprayer.
Spray., When needed., Sprayer.
ORNAMENTAL AND/OR SHADE TREES
Spray., When needed., Sprayer.
Sprinkle., When needed., Sprinkler can.
Directed spray., When needed., Sprayer. SC/L NA
I't)
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
IN
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
Use Group
1 Ib (CI) -- *
UC *
.008 Ib (CI) -- *
1 Ib (CI) -- *
.1 Ib (CI) -- *
.013 Ib (CI) -- *
UC *
.01038 Ib (CI) -- *
Use Group
.5 Ib (CI) -- *
Use Group
.01042 Ib (CI) -- *
1 Ib (CI) -- *
.013 Ib (CI) -- *
Use Group
.02 Ib (CI) IK *
sq.ft
.02 Ib (CI) IK *
sq.ft
Use Group
.01038 Ib (CI) -- *
.01016 Ib (CI) -- *
: TERR
NS
NS
NS
NS
NS
NS
NS
: TERR
NS
: TERR
NS
NS
NS
: TERR
NS
NS
: TERR
NS
NS
EST1
NS
NS
NS
NS
NS
NS
NS
EST1
NS
EST1
NS
NS
NS
EST1
NS
NS
EST1
NS
NS
TERRESTRIAL NON-FOOD CROP (con't)
NS NS AN NS
NS
NS
NS AN
NS AN
NS
NS
NS NS AN NS
NS NS AN NS
NS NS NS NS
NON-FOOD CROP
NS NS AN 1
TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL
NS NS AN NS
NS
NS AN
NS
NS NS AN
-FOOD CROP
NS NS AN
NS
NS AN
NS
TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL
NS NS AN 1
NS NS AN NS
C46, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91, CAE
C86, C89, C90, C91,
C92
CSS, C89, C90, C91
C90, C91, CAE
C86, CSS, C90, C91
CSS, C90, C91
C46, C86, C92, C98,
CA1, GK6
C46, C89, C90, C91,
C92
CSS, C89, C90, C91
CSV, CAE, CAG
C, CSV, CAE, CAG
CAE
C92
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 39
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
ORNAMENTAL AND/OR SHADE TREES (con't)
Edging treatment., When needed., Sprayer.
SC/L NA
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
.005078 Ib (CI)
C86, CSS, C90, C91
Spot treatment., When needed., Sprayer.
Spray., When needed., Hose-end sprayer.
Spray., When needed., Sprayer.
Spray., When needed., Sprinkler can.
Spray., When needed., Tank-type sprayer.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.01038 Ib
.01016 Ib
.013 Ib
.01016 Ib
.013 Ib
1 Ib
.01042 Ib
1 Ib
.54 Ib
.01042 Ib
.013 Ib
.2 Ib
.01038 Ib
(CI) --
UC
(CI) --
UC
(CI) --
(CI) --
(CI) --
(CI) --
(CI) --
(CI) --
(CI) --
(CI) --
(CI) --
UC
(CI) --
(CI) --
UC
UC
UC
* NS
* NS
*
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
NS
AN
NS
AN
1
NS
NS
1
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
CAE
C92
C92
C86,
C91
C86,
C86,
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
CSS,
C90,
C46,
C91
C86,
C92
CAE
C92
CSS, C89, C90,
CSS, C90, C91
C90, C91
C89, C90, C91,
CSS, C89, C90,
CSS, C89,
CAE
C89, C90,
C89, C90,
C89, C90,
C91, CAE
C86, CSS, C90,
CSS, C90, C91
C90,
C91
C91,
C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 40
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
ORNAMENTAL AND/OR SHADE TREES (con't)
Spray., When needed., Trigger spray bottle. SC/L NA
ORNAMENTAL HERBACEOUS PLANTS
Edging treatment., When needed., Sprayer.
Spray., When needed., Sprayer.
Spray., When needed., Trigger spray bottle. SC/L NA
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.004215
.005078
.013 Ib
.01016 Ib
.013 Ib
.01042 Ib
1 Ib
.008 Ib
1 Ib
.54 Ib
.01042 Ib
.013 Ib
.01038 Ib
.004215
Use Group
UC *
Ib (CI) *
Use Group
Ib (CI) *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
UC *
(CI) -- *
Ib (CI) *
: TERRESTRIAL
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NON- FOOD +
NS
NS
OUTDOOR
NS
NS
NON- FOOD+OUTDOOR
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
RESIDENTIAL
NS
AN
NS
1
RESIDENTIAL
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
AN
1
1
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
C46, C86, CSS, C90,
C91, GA4
C86, CSS, C90, C91
C86,
C91
C86,
C86,
C46,
CA1,
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
CSS,
C90,
C86,
C46,
C91,
CSS, C89, C90,
CSS, C90, C91
C90, C91
C86, C92, C98,
GK6
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91
C89, C90, C91,
C89, C90, C91
C91, CAE
CSS, C90, C91
C86, CSS, C90,
GA4
ORNAMENTAL LAWNS AND TURF
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 41
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
ORNAMENTAL LAWNS AND TURF (con't)
Edging treatment., When needed., Sprayer. SC/L NA
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
.005078 Ib (CI)
C86, CSS, C90, C91
Spot treatment., When needed., Sprayer.
Spray., When needed., Sprayer.
Spray., When needed., Trigger spray bottle. SC/L NA
ORNAMENTAL NONFLOWERING PLANTS
Edging treatment., When needed., Sprayer. SC/L NA
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.013
.01016
.013
.01894
1
.01042
1
.54
.01042
.013
.01038
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
.004215
UC
(CI) --
(CI) --
(CD --
(CD --
(CD --
(CD --
(CD --
(CD --
(CD --
(CD --
uc
(CD --
Ib (CI)
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
AN
NS
1
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
C86, CSS, C89, C90,
C91
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
CSS,
C90,
C86,
C46,
C91,
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91
C89, C90, C91,
C89, C90, C91
C91, CAE
CSS, C90, C91
C86, CSS, C90,
GA4
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL
.005078 Ib (CI) * NS NS NS NS AN 1
C86, CSS, C90, C91
Spray., When needed., Sprayer.
SC/L NA
.013 Ib (CI) -- * NS
NS
NS
NS AN
1
C86, CSS, C89, C90,
C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 42
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
ORNAMENTAL NONFLOWERING PLANTS (con't)
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
Spray., When needed., Trigger spray bottle. SC/L NA
ORNAMENTAL PONDS/AQUARIA
Injection treatment., When needed.,
Injection.
Pour-on., When needed., Boat.
ORNAMENTAL WOODY SHRUBS AND VINES
Spray., When needed., Sprayer.
Sprinkle., When needed., Sprinkler can.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.01016
.013
1
.01042
1
.54
.01042
.013
.01038
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
Ib
.004215
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
UC *
(CI) -- *
Ib (CI) *
Use Group
.083 Ib (CI) *
injection
3.984
.02
.02
Ib
Ib
Ib
(CI) A *
Use Group
(CI) IK *
sq.ft
(CI) IK *
sq.ft
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
: AQUATIC
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
AN
1
1
NS
NS
NS
NS
NS
NS
NS
NS
1
NON-FOOD RESIDENTIAL
NS
NS
: TERRESTRIAL NON- FOOD
NS
NS
NS
NS
NS
NS
NS
NS
CROP
NS
NS
AN
AN
AN
AN
1
1
NS
NS
C86,
C86,
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
CSS,
C90,
C86,
C46,
C91,
CSS, C90, C91
C90, C91
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91
C89, C90, C91,
C89, C90, C91
C91, CAE
CSS, C90, C91
C86, CSS, C90,
GA4
C46, C86, CSS, C90,
C91, GA4
C46, C86, CSS, C90,
C91, GA4
CSV, CAE, CAG
CSV, CAE, CAG
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 43
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
ORNAMENTAL WOODY SHRUBS AND VINES (con't)
Directed spray., When needed., Sprayer.
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
Directed spray., When needed., Trigger spray RTU NA
bottle.
Edging treatment., When needed., Sprayer. RTU NA
SC/L NA
RTU
SC/L
SC/L
SC/L
RTU
RTU
RTU
RTU
NA
NA
NA
NA
NA
NA
NA
NA
.05 Ib (CI)
sq
.01038 Ib (CI)
.01016 Ib (CI)
.02 Ib (CI)
sq
.05 Ib (CI)
IK
.ft
--
--
IK
.ft
UC
UC
UC
IK
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
NS
AN
AN
AN
NS
NS
1
NS
NS
NS
NS
NS
NS
sq.ft
.005078 Ib (CI)
CAE, CAG
CAE
C92
C92
CAE
CAG
CAE, CAG
C86, CSS, C90, C91
Spot treatment., When needed., Sprayer.
Spray., When needed., Hand held sprayer.
Spray., When needed., Hose-end sprayer.
Spray., When needed., Mechanical sprayer.
Spray., When needed., Sprayer.
RTU NA .05 Ib (CI) IK * NS NS
sq.ft
SC/L NA .01038 Ib (CI) -- * NS NS
SC/L NA UC * NS NS
.01016 Ib (CI) -- *
SC/L NA .02 Ib (CI) IK * NS NS
sq.ft
RTU NA .02 Ib (CI) IK * NS NS
sq.ft
SC/L NA UC * NS NS
RTU NA .02 Ib (CI) IK * NS NS
sq.ft
RTU NA UC * NS NS
SC/L NA .013 Ib (CI) -- * NS NS
NS
NS NS
NS
NS NS AN 1
NS NS AN NS
NS
NS
NS
NS
NS
NS NS
NS AN
NS
NS
NS AN NS
NS AN NS
NS AN NS
NS AN 1
CAE, CAG
CAE
C92
CAE, CAG
C92
CAE, CAG
CAG
C86, CSS, C89, C90,
C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 44
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
ORNAMENTAL WOODY SHRUBS AND VINES (con't)
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
Spray., When needed., Sprinkler can.
Spray., When needed., Squeeze applicator.
Spray., When needed., Tank-type sprayer.
Spray., When needed., Trigger spray bottle. SC/L NA
Sprinkle., When needed., Sprinkler can.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
RTU
SC/L
SC/L
SC/L
RTU
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.01016 Ib (CI) --
.013 Ib (CI) --
.01894 Ib (CI) --
1 Ib (CI) --
UC
.01042 Ib (CI) --
1 Ib (CI) --
.54 Ib (CI) --
.01042 Ib (CI) --
.013 Ib (CI) --
UC
.01038 Ib (CI) --
UC
UC
UC
UC
UC
.004215 Ib (CI)
.02 Ib (CI) IK
sq.ft
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
AN
NS
NS
AN
NS
AN
AN
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
NS
C86, CSS, C90, C91
C86, C90, C91
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
CSS,
C90,
C86,
C92
CAE
C92
CAE
C46, C86, CSS, C90,
C91, GA4
CAE, CAG
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91
C89, C90, C91,
C89, C90, C91
C91, CAE
CSS, C90, C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 45
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
PATHS/PATIOS
Directed spray., When needed., Sprayer.
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL
Directed spray., When needed., Sprinkler
can.
Directed spray., When needed., Squeeze
applicator.
Directed spray., When needed., Tank.
Directed spray., When needed., Trigger spray RTU NA
bottle.
Edging treatment., When needed., Sprayer. RTU NA
Spot treatment., When needed., Sprayer.
RTU
SC/L
SC/L
SC/L
RTU
RTU
SC/L
RTU
RTU
RTU
SC/L
RTU
RTU
SC/L
RTU
RTU
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.05 Ib (CI) IK
sq.ft
.009727 Ib (CI)
.01038 Ib (CI) --
.01016 Ib (CI) --
UC
UC
UC
UC
UC
UC
UC
UC
.05 Ib (CI) IK
sq.ft
.005078 Ib (CI)
UC
.05 Ib (CI) IK
sq.ft
.01038 Ib (CI) --
UC
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
NS
NS
NS
AN
AN
AN
NS
AN
NS
AN
AN
NS
AN
AN
NS
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
1
NS
NS
1
NS
CAE, CAG
C46, C86, CSS, C90,
C91, GA4
CAE
C92
CAE, CAG, GLS
CAE, CAG, GLS
C92
CAE
CAG
C87
CAE, CAG
C86, CSS, C90, C91
C87
CAE, CAG
CAE
C92
.01016 Ib (CI) --
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 46
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
PATHS/PATIOS (con't)
Spot treatment., When needed., Sprinkler
can.
Spray., When needed., Hose-end sprayer.
Spray., When needed., Sprayer.
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
UC * NS NS NS NS NS NS
Spray., When needed., Sprinkler can.
SC/L
RTU
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
UC
UC
.013 Ib (CI) --
.005078 Ib (CI)
.013 Ib (CI) --
.01894 Ib (CI) --
.01042 Ib (CI) --
1 Ib (CI) --
UC
.01042 Ib (CI) --
1 Ib (CI) --
.54 Ib (CI) --
.01042 Ib (CI) --
.013 Ib (CI) --
.5 Ib (CI) --
UC
.01038 Ib (CI) --
UC
UC
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
*
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
AN
NS
AN
NS
NS
NS
1
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
CAE, CAG, GL8
C92
CAG
C86, CSS, C89, C90,
C91
C86, CSS, C90, C91
C86, C90, C91
C46,
CA1,
C46,
C92
C86,
C91
C86,
C91,
C86,
C86,
C92
CSS,
CSS,
C90,
C86,
C92
CAE
C86, C92, C98,
GK6
C89, C90, C91,
CSS, C89, C90,
CSS, C89, C90,
CAE
C89, C90, C91
C89, C90, C91,
C89, C90, C91
C90, C91
C91, CAE
CSS, C90, C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 47
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
PATHS/PATIOS (con't)
Spray., When needed., Tank-type sprayer.
Spray., When needed., Trigger spray bottle.
Sprinkle., When needed., Sprayer.
Sprinkle., When needed., Sprinkler can.
PAVED AREAS (PRIVATE ROADS/SIDEWALKS)
Directed spray., When needed., Sprayer.
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
Directed spray., When needed., Sprinkler
can.
Directed spray., When needed., Squeeze
applicator.
Directed spray., When needed., Tank.
Directed spray., When needed., Trigger spray
bottle.
Edging treatment., When needed., Sprayer.
SC/L
SC/L
RTU
RTU
RTU
SC/L
RTU
SC/L
SC/L
SC/L
RTU
RTU
SC/L
RTU
RTU
RTU
SC/L
RTU
RTU
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
UC *
UC *
UC *
UC *
UC *
UC *
Use Group
.05 Ib (CI) IK *
sq.ft
.009727 Ib (CI) *
.01038 Ib (CI) -- *
.01016 Ib (CI) -- *
UC *
UC *
UC *
UC *
UC *
UC *
UC *
UC *
.05 Ib (CI) IK *
sq.ft
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NON- FOOD -
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
nOUTDOOR
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
NS
NS
NS
AN
NS
RESII
NS
AN
AN
AN
NS
NS
NS
AN
AN
AN
NS
AN
NS
NS
NS
NS
NS
NS
NS
5ENTI,
NS
1
1
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
C92
CAE
CAE, CAG, G74
CAE, CAG, G74
CAG
CAE, CAG
C46, C86, CSS, C90,
C91, GA4
CAE
C92
CAE, CAG, GLS
CAE, CAG, GLS
C92
CAE
CAG
C87
CAE, CAG
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 48
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) (con't)
SC/L NA
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
.005078 Ib (CI) * NS NS NS NS AN 1
C86, CSS, C90, C91
Spot treatment., When needed., Sprayer.
SC/L NA
RTU NA
RTU NA
SC/L NA
SC/L NA
.02 Ib (CI) IK * NS NS
sq.ft
.05 Ib (CI) IK * NS NS
sq.ft
.01038 Ib (CI) -- * NS NS
UC * NS NS
.01016 Ib (CI) -- *
NS
NS
NS
NS
NS
NS NS
NS AN
NS NS
NS AN
NS AN
NS
NS
NS
1
NS
CSV
CAE, CAG
CAE
C92
Spot treatment., When needed., Sprinkler
can.
SC/L NA
RTU NA
.02 Ib (CI) IK * NS NS
sq.ft
UC * NS NS
NS NS
NS NS
CAE, CAG, GL8
Spray., When needed., Hose-end sprayer.
Spray., When needed., Sprayer.
SC/L NA
RTU NA
SC/L NA
UC * NS NS
UC * NS NS
.013 Ib (CI) -- * NS NS
NS
NS
NS
NS AN
NS AN
NS AN
NS
NS
1
C92
CAG
C86, CSS, C89, C90,
C91
SC/L NA
.005078 Ib (CI) * NS NS
NS AN
C86, CSS, C90, C91
SC/L NA
SC/L NA
SC/L NA
SC/L NA
SC/L NA
.013 Ib (CI) -- * NS NS
.01894 Ib (CI) -- * NS NS
.01042 Ib (CI) -- * NS NS
1 Ib (CI) -- * NS NS
UC * NS NS
.01042 Ib (CI) -- *
NS
NS
NS
NS AN
NS AN
NS AN
NS AN
1
NS
NS
C86, C90, C91
C46, C86, C92, C98,
CA1, GK6
C46, C89, C90, C91,
C92
C86, CSS, C89, C90,
C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 49
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
PAVED AREAS (PRIVATE ROADS/SIDEWALKS) (con't)
SC/L NA
Use Group: TERRESTRIAL NON-FOOD+OUTDOOR RESIDENTIAL (con't)
1 Ib (CI) -- * NS NS NS NS AN NS
Spray., When needed., Sprinkler can.
Spray., When needed., Squeeze applicator.
Spray., When needed., Tank-type sprayer.
Spray., When needed., Trigger spray bottle.
Sprinkle., When needed., Sprayer.
Sprinkle., When needed., Sprinkler can.
RECREATION AREA LAWNS
Broadcast., Dormant., Ground.
C86, CSS, C89, C90,
C91, CAE
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
RTU
SC/L
SC/L
RTU
RTU
RTU
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
.54 Ib (CI) -- * NS
.01042 Ib (CI) -- * NS
.013 Ib (CI) -- * NS
.5 Ib (CI) -- * NS
UC * NS
.01038 Ib (CI) -- * NS
UC * NS
UC * NS
UC * NS
UC * NS
UC * NS
UC * NS
UC * NS
UC * NS
UC * NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
Use Group: TERRESTRIAL
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
.5 Ib (CI) -- * NS
.5 Ib (CI) -- * NS
.5 Ib (CI) -- * NS
.5 Ib (CI) -- * NS
.5 Ib (CI) -- * NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NON -FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
CROP
NS
NS
NS
NS
NS
AN
AN
AN
AN
AN
NS
AN
NS
NS
AN
NS
NS
NS
AN
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS AR
NS LA
NS MS
NS OK
NS OK
C86, C89, C90, C91
C86, C89, C90, C91
C92
CSS, C89, C90, C91
CSS, C90, C91
C90, C91, CAE
C86, CSS, C90, C91
C92
CAE
C92
CAE
CAE, CAG, G74
CAE, CAG, G74
CAG
C46
C46
C46
C46
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 50
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
RECREATION AREA LAWNS (con't)
RECREATIONAL AREAS
Broadcast., Dormant., Ground.
Use Group: TERRESTRIAL NON-FOOD CROP (con't)
Injection treatment., When needed.
Injection.
Pour-on., When needed., Boat. SC/L NA
RESIDENTIAL LAWNS
Directed spray., When needed., Trigger spray RTU NA
bottle.
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
.5 Ib
.5 Ib
.5 Ib
.5 Ib
.5 Ib
.5 Ib
.5 Ib
.5 Ib
(CI) -- *
(CI) -- *
Use Group
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
(CI) -- *
.083 Ib (CI) *
injection
NS
NS
NS
NS
: TERRESTRIAL
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NON -FOOD
NS
NS
NS
NS
NS
NS
NS
NS
NS
CROP
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
NS
NS
NS
NS
NS
NS
NS
NS
NS
TN
TX
AR
LA
MS
OK
OK
TN
C46
C46
C46
C46
C46
C46
C46
C46
C91
Spray., When needed., Sprayer.
Sprinkle., When needed., Sprinkler can.
STREAMS/RIVERS/CHANNELED WATER
Aquatic deep water injection/bottom
placement application., Spring., Weighted
trailing hose.
RTU
RTU
NA
NA
SC/L NA
SC/L NA
Aquatic deep water injection/bottom SC/L NA
placement application., Summer., Weighted
trailing hose.
3.984 Ib (CI) A
NS
NS
NS
Use Group: OUTDOOR RESIDENTIAL
UC * NS NS NS
NS AN
UC * NS NS NS NS AN
UC * NS NS NS NS AN
Use Group: AQUATIC NON-FOOD OUTDOOR
4 Ib (CI) A * NS NS NS NS NS
4 Ib (CI) A * NS NS NS NS NS
4 Ib (CI) A * NS NS NS NS NS
NS
NS
C46, C86, CSS, C90,
C46, C86, CSS, C90,
C91, GA4
CAG
CAG
CAG
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
C07, CSS, C89, C90,
C91, CA1
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 51
SITE Application Type, Application Form(s) Min. Appl. Max. Appl. Soil Max. # Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Timing, Application Equipment ) Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
Surface Type (Antimicrobial only) & Effica- less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
cy Influencing Factor (Antimicrobial only)
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
STREAMS/RIVERS/CHANNELED WATER (con't)
Aquatic deep water injection/bottom
placement application., When needed.,
Weighted trailing hose.
Aquatic subsurface injection application.,
When needed., Trailing hose.
Edging treatment., Prebloom., Sprayer.
Pour-on., When needed., Boat.
Shoreline treatment., Prebloom., Sprayer.
Spray., Foliar., Sprayer.
Water treatment (subsurface)., When needed.
Boat.
Water treatment (surface)., Spring.,
Sprayer.
Water treatment (surface)., Summer.,
Sprayer.
Water treatment (surface)., When needed.
Aircraft.
Water treatment (surface)., When needed.
Sprayer.
Use Group: AQUATIC NON-FOOD OUTDOOR (con't)
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
SC/L
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
2 Ib (CI)
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
4 Ib (CI)
1.5 Ib (CI)
1.5 Ib (CI)
4 Ib (CI)
A
A
A
A
A
A
A
UC
uc
UC
A
A
A
A
A
A
A
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
* NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
AN
NS
AN
NS
AN
AN
AN
AN
AN
NS
NS
NS
NS
AN
NS
AN
NS TN
NS
NS FL
NS
NS FL
NS FL
NS
NS
NS
NS
NS AL
NS TN
NS AL
NS TN
NS
NS FL
NS
C07,
C91,
FL C46,
CA1,
C89,
FL C46,
CA1,
C89,
C89,
FL C46,
CA1,
CSS,
CSS,
CSS,
C07,
C91,
C07,
C91,
C07,
C91,
C07,
C91,
FL C46,
CA1,
C89,
FL C46,
CA1,
CSS,
CA1
C86,
GK6
C90,
C86,
GK6
C90,
C90,
C86,
GK6
C89,
C89,
C89,
CSS,
CA1
CSS,
CA1
CSS,
CA1
CSS,
CA1
C86,
GK6
C90,
C86,
GK6
C89,
C92,
C91
C92,
C91
C91
C92,
C90,
C90,
C90,
C89,
C89,
C89,
C89,
C92,
C91
C92,
C90,
C98,
C98,
C98,
C91
C91
C91
C90,
C90,
C90,
C90,
C98,
C98,
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 52
SITE Application Type, Application Form(s)
Timing, Application Equipment )
Surface Type (Antimicrobial only) & Effica-
cy Influencing Factor (Antimicrobial only)
Min. Appl. Max. Appl. Soil Max. tt Apps Max. Dose [(AI Min. Restr. Geographic Limitations Use
Rate (AI un- Rate (AI Tex. @ Max. Rate unless noted Interv Entry Allowed Disallowed Limitations
less noted unless noted Max. /crop /year otherwise)/A] (days) Interv Codes
otherwise) otherwise) Dose cycle /crop /year [day(s)]
cycle
USES ELIGIBLE FOR REREGISTRATION
NON-FOOD/NON-FEED (con't)
STREAMS/RIVERS/CHANNELED WATER (con't)
SC/L NA
Water treatment., When needed., Helicopter. SC/L NA
Use Group: AQUATIC NON-FOOD OUTDOOR (con't)
4 Ib (CI) A * NS NS NS NS AN NS FL
20 Ib (CI) * NS NS NS NS NS NS FL
C89, C90, C91
C89, C90, C91
-------
Report Run Date: 03/15/95 ) Time 09:50
APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide]
LUIS 2.0 ) Page 53
LEGEND
444444
HEADER ABBREVIATIONS
Min. Appl. Rate (AI unless : Minimum dose for a single application to a single site. System calculated. Microbial claims only.
noted otherwise)
Max. Appl. Rate (AI unless : Maximum dose for a single application to a single site. System calculated.
noted otherwise)
. Maximum dose for a single application to a single site as related to soil texture (Herbicide claims only).
. Maximum number of Applications at Maximum Dosage Rate. Example: "4 applications per year" is expressed as "4/1 yr"; "4 applications per 3
years" is expressed as "4/3 yr"
. Maximum dose applied to a site over a single crop cycle or year. System calculated.
Soil Tex. Max. Dose
Max. # Apps © Max. Rate
Max. Dose [(AI unless
noted otherwise)/A]
Min. Interv (days)
Minimum Interval between Applications (days)
Restr. Entry Interv (days) : Restricted Entry Interval (days)
PRO Report Date
LUIS contains all products that were active or suspended (and that were available from OPP Document Center) as of this date. Some products
registered after this date may have data included in this report, but LUIS does not guarantee that all products registered after this date have
data that has been captured.
SOIL TEXTURE FOR MAX APP. RATE
* : Non-specific
C : Coarse
M : Medium
F : Fine
O : Others
FORMULATION CODES
RTU : LIQUID-READY TO USE
SC/L : SOLUBLE CONCENTRATE/LIQUID
ABBREVIATIONS
AN : As Needed
NA : Not Applicable
NS : Not Specified (on label)
UC : Unconverted due to lack of data (on label), or with one of following units: bag, bait, bait block, bait pack, bait station, bait station(s), block, briquet,
briquets, bursts, cake, can, canister, capsule, cartridges, coil, collar, container, dispenser, drop, eartag, grains, lure, pack, packet, packets, pad, part,
parts, pellets, piece, pieces, pill, pumps, sec, sec burst, sheet, spike, stake, stick, strip, tab, tablet, tablets, tag, tape, towelette, tray, unit, --
APPLICATION RATE
DCNC
No Calc
W
V
U
cwt
nnE-xx
Dosage Can Not be Calculated
No Calculation can be made
PPM calculated by weight
PPM Calculated by volume
Unknown whether PPM is given by weight or by volume
Hundred Weight
nn times (10 power -xx); for instance, "1.234E-04"
is equivalent to ".0001234"
USE LIMITATIONS CODES
C :
C07 : Do not apply within yard(s) of potable water intake.
C14 : Grown for seed only.
C40 : Do not apply by aircraft.
C46 : Do not apply through any type of irrigation system.
C86 : Do not apply directly to water except as specified on the product label.
CSV : Do not apply directly to water or wetlands, or where runoff is likely to occur.
-------
Report Run Date: 03/15/95 ) Time 09:50 APPENDIX A ) CASE 0288, [Diquat Dibromide] Chemical 032201 [Diquat dibromide] LUIS 2.0 ) Page 54
USE LIMITATIONS CODES (Cont.)
CSS : Do not use treated water for domestic purposes until day(s) after treatment.
C89 : Do not use treated water for drinking purposes until day(s) after treatment.
C90 : Do not use treated water for spraying or irrigation within day(s) after treatment.
C91 : Do not use treated water for animal consumption within day(s) after treatment.
C92 : For terrestrial uses, do not apply directly to water or to areas where surface water is present or to intertidal areas below the mean high water mark.
C98 : Do not apply in areas where commercial fish processing, resulting in the production of fish protein concentrate or fish meal, is practiced.
C99 : Do not treat water where depth is feet or less.
CA1 : Aquatic applications are allowed only by the Corps of Engineers or other Federal or State Public Agencies, or contractors or licensees under their direct control.
CAE : Do not apply directly to water or wetlands (swamps, bogs, marshes, and potholes).
CAG : Do not apply where runoff is likely to occur.
G68 : Do not graze livestock on treated fields or feed treated trash.
G74 : Do not feed treated foliage to livestock or graze treated areas.
G88 : Do not graze or feed forage.
GA4 : Do not feed treated forage to livestock.
GI7 : Do not use seed for food, feed or oil purposes.
GK6 : Do not feed forage from treated areas.
GL5 : Do not use seed from treated plants for food or feed.
GL8 : Do not allow the feeding or grazing of foliage by livestock.
HOI : day(s) preharvest interval.
H03 : Preharvest interval not located on the label.
* NUMBER IN PARENTHESES REPRESENTS THE NUMBER OF TIME UNITS (HOURS,DAYS, ETC.) DESCRIBED IN THE LIMITATION.
GEOGRAPHIC CODES
AL : Alabama
AR : Arkansas
CA : California
FL : Florida
GA : Georgia
ID : Idaho
LA : Louisiana
ME : Maine
MI : Michigan
MN : Minnesota
MS : Mississippi
MT : Montana
ND : North Dakota
NE : Nebraska
NV : Nevada
NY : New York
OK : Oklahoma
OR : Oregon
PR : Puerto Rico
TN : Tennessee
TX : Texas
WA : Washington
WI : Wisconsin
-------
APPENDIX B. Table of the Generic Data Requirements
and Studies Used to Make the Reregistration Decision
143
-------
144
-------
GUIDE TO APPENDIX B
Appendix B contains listings of data requirements which support the reregistration for active
ingredients within the case Diquat Dibromide covered by this Reregistration Eligibility
Decision Document. It contains generic data requirements that apply to Diquat Dibromide in
all products, including data requirements for which a "typical formulation" is the test
substance.
The data table is organized in the following format:
1. Data Requirement (Column 1). The data requirements are listed in the order in
which they appear in 40 CFR Part 158. the reference numbers accompanying each test refer
to the test protocols set in the Pesticide Assessment Guidelines, which are available from the
National Technical Information Service, 5285 Port Royal Road, Springfield, VA 22161 (703)
487-4650.
2. Use Pattern (Column 2). This column indicates the use patterns for which the data
requirements apply. The following letter designations are used for the given use patterns:
A Terrestrial food
B Terrestrial feed
C Terrestrial non-food
D Aquatic food
E Aquatic non-food outdoor
F Aquatic non-food industrial
G Aquatic non-food residential
H Greenhouse food
I Greenhouse non-food
J Forestry
K Residential
L Indoor food
M Indoor non-food
N Indoor medical
0 Indoor residential
3. Bibliographic citation (Column 3). If the Agency has acceptable data in its files,
this column lists the identifying number of each study. This normally is the Master Record
Identification (MRID) number, but may be a "GS" number if no MRID number has been
assigned. Refer to the Bibliography appendix for a complete citation of the study.
145
-------
146
-------
APPENDIX B
Data Supporting Guideline Requirements for the Reregistration of Diquat Dibromide
REQUIREMENT USE PATTERN CITATION(S)
Registrant: Zeneca Ag Products
Product: 10182-376 and 10182-378
PRODUCT CHEMISTRY
61-1 Chemical Identity Data gap
61-2A Start. Mat. & Mnfg. Process No MRID no.
61-3 Formation of Impurities No MRID no.
62-1 Preliminary Analysis 40323601,40429601
62-2 Certification of Ingredient limits 40323601,40429601, Data gap
62-3 Analytical Method 40323601,40429601
63-2 Color 00038627
63-3 Physical State 00038627
63-4 Odor 00136329
63-5 Melting Point 00115555
63-7 Density 00115555
63-8 Solubility 00136329,40302701
63-10 Dissociation Constant 00138938
63-12 pH Data gap
147
-------
Data Supporting Guideline Requirements for the Reregistration of Diquat Dibromide
REQUIREMENT USE PATTERN CITATION(S)
63-13 Stability
63-14 Oxidizing/Reducing Action
63-16 Explodability
63-17 Storage stability
63-18 Viscosity
63-20 Corrosion characteristics
ECOLOGICAL EFFECTS
71-1A Acute Avian Oral - Quail/Duck
71-2A Avian Dietary - Quail
71-2B Avian Dietary - Duck
71-4A Avian Reproduction - Quail
71-4B Avian Reproduction - Duck
72-IB Fish Toxicity - Bluegill - TEP
72-ID Fish Toxicity - Rainbow Trout-TEP
72-2A Invertebrate Toxicity
72-3A Estuarine/Marine Toxicity - Fish
72-3B Estuarine/Marine Toxicity -
Mollusk
72-3C Estuarine/Marine Toxicity -
Shrimp
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
A.B.C.E
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
00038627, 00138928
40069304
40069304
40069304
40069304
40069304
00106559, G59999001
00022923, 00116565
0002293
00119988
00114230
00138963,00115572,00027203,00138962,
00003503
00138963,00115858,00028002,
00003503,00138961
00003503.00115576,00115862
40316001,00028002
40316001
40315701
148
-------
Data Supporting Guideline Requirements for the Reregistration of Diquat Dibromide
REQUIREMENT
72-4A
72-4B
122-1B
122-2
123-1B
123-2
141-1
Early Life Stage Fish
Life Cycle Invertebrate
Vegetative Vigor
Aquatic Plant Growth
Vegetative Vigor
Aquatic Plant Growth
Honey Bee Acute Contact
USE PATTERN
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
CITATION(S)
4030703
40380702
40165102
40165103,40165104,40165105
41883001, another study reqd
41883002, D212863inrev.
00131562,40208001
TOXICOLOGY
81-1
81-2
81-3
81-4
81-5
81-6
81-8
82-1A
82-2
82-4
82-4B
82-7
Acute Oral Toxicity - Rat
Acute Dermal Toxicity -
Rabbit/Rat
Acute Inhalation Toxicity - Rat
Primary Eye Irritation - Rabbit
Primary Dermal Irritation - Rabbit
Dermal Sensitization - Guinea Pig
Acute Neurotoxicity - Rat
90-Day Feeding - Rodent
21 -Day Dermal - Rabbit/Rat
90-Day Inhalation - Rat
21 -Day Inhalation - Rat
Subchronic Neurotoxicity - Rats
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
A,C,E
00081506
00100614
00081507
00107903
00155475
42666801
40185601
00145056
40301701
40440801
42616101
149
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Data Supporting Guideline Requirements for the Reregistration of Diquat Dibromide
REQUIREMENT USE PATTERN CITATION(S)
83-1A Chronic Feeding Toxicity - Rodent
83-IB Chronic Feeding Toxicity -
Non-Rodent
83-2A Oncogenicity - Rat
83-2B Oncogenicity - Mouse
83-2B Oncogenicity - Mouse
83-3A Developmental Toxicity - Rat
83-3B Developmental Toxicity - Rabbit
83-4 2-Generation Reproduction - Rat
84-2A Gene Mutation (Ames Test)
84-2B Structural Chromosomal
Aberration
85-1 General Metabolism
85-2 Dermal Penetration
85-2 (sp) Dermal Absorption
ENVIRONMENTAL FATE
161-1 Hydrolysis
161-2 Photodegradation - Water
161-3 Photodegradation - Soil
162-1 Aerobic Soil Metabolism
162-2 Anaerobic Soil Metabolism
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
A,B,C,E
00145855, 00155474
41730301
00145855, 00160673
42219801
42880701, 42905901, 42919501
224405, 41198902, 00061637
00061635, 41198901
41531301
40323103, 40323101
40323106, 40323107, 40323104, 00061638
00055107, 00065592, 00065593
41238701
41247201, 41247202
41247203, 41247204
000154100
40418801
40246101
40972301
40972302
150
-------
Data Supporting Guideline Requirements for the Reregistration of Diquat Dibromide
REQUIREMENT USE PATTERN
162-3
162-4
163-1
163-2
164-1
164-2
164-5
165-4
165-5
RESIDUE
171-4A
Anaerobic Aquatic Metabolism A,B,C,E
Aerobic Aquatic Metabolism A,B,C,E
Leaching/Adsorption/Desorption A , B , C , E
Volatility - Lab A,B,C,E
Terrestrial Field Dissapation:soil A,B,C,E
Aquatic Field Dissipation A,B,C,E
Long Term Soil Dissipation A , B , C , E
Bioaccumulation in Fish A,B,C,E
Bioaccumulation - Aquatic E
NonTarget
CHEMISTRY
Nature of Residue - Plants A , B , D
CITATION(S)
40972302
40927601
40348601
40245101
42060301,4260302
40917403
40335201
40326901
40326903
40326902
40326904
40380701
00055086, 00056905,
00065600, 00065602,
00067157, 00067162,
00068221, 00115563,
00115583, 00116728,
00121305, 00121307,
40001301, 40391501,
41149401, 43028401
151
-------
Data Supporting Guideline Requirements for the Reregistration of Diquat Dibromide
REQUIREMENT
USE PATTERN
CITATION(S)
171-4B
Nature of Residue - Livestock
171-4C/D Residue Analytical Method - Plants
171-4E Storage Stability
171-4F Magnitude of the Residue in
Potable Water
171-4G Magnitude of the Residue in Fish
and Shellfish
171-4H Magnitude of the Residue in
Irrigated Crops
171-4J Magnitude of the Residue in
Poultry and Eggs
Cattle, goats, hogs, horses, and
sheep
Poultry and Eggs
00065594,
00065596,
00065599,
00068229,
00114410,
40535001
00065595.
00065597,
00065560,
00071328,
00122705,
, 40555501
00071325, 00071326,
00114449, 00115546,
00115547, 00115559,
00116728, 00116736,
00116739, GS0288002,
40308001, 40308002,
40555501, data gap
40427601, 40811101,
40811102, 40811103,
41940905
00068228, 00068229
PP#1F1101, 00068228,
00135717, 40427601
00031836, 40535905
No MRID no.
00031841, 00140582
00116739
152
-------
Data Supporting Guideline Requirements for the Reregistration of Diquat Dibromide
REQUIREMENT USE PATTERN CITATION(S)
171-4k
Milk
Magnitude of Residues -Plants
00031841, 00140582
42822002, 40535901
Root and Tuber Vegetables Group
Potato
Fruiting Vegetables Group
Pepper
Tomato
Curcurbit Vegetables Group
Cantaloupe
Cucumber
Squash
Watermelon
Miscellaneous Commodities
Sugarcane
00116728, 00140590
No MRID no.
No MRID no.
00100410, 00140586
Crops Grown Solely for Seed
Alfalfa
Carrot
Clover
Radish
40535901, 42822002
00067154
40535902, 42822001
No MRID no.
153
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Data Supporting Guideline Requirements for the Reregistration of Diquat Dibromide
REQUIREMENT USE PATTERN CITATION(S)
Sorghum 00115575,40535903
Soybean 00115575,40535904
Turnip No MRID no.
Vetch No MRID no.
171-41 Magnitude of Residues - Processed
Food/Feed
154
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APPENDIX C. Citations Considered to be Part of the Data
Base Supporting the Reregistration of Diquat Dibromide
155
-------
156
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GUIDE TO APPENDIX C
1. CONTENTS OF BIBLIOGRAPHY. This bibliography contains citations of all studies
considered relevant by EPA in arriving at the positions and conclusions stated
elsewhere in the Reregistration Eligibility Document. Primary sources for studies in
this bibliography have been the body of data submitted to EPA and its predecessor
agencies in support of past regulatory decisions. Selections from other sources
including the published literature, in those instances where they have been considered,
are included.
2. UNITS OF ENTRY. The unit of entry in this bibliography is called a "study". In the
case of published materials, this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency has sought to identify
documents at a level parallel to the published article from within the typically larger
volumes in which they were submitted. The resulting "studies" generally have a
distinct title (or at least a single subject), can stand alone for purposes of review and
can be described with a conventional bibliographic citation. The Agency has also
attempted to unite basic documents and commentaries upon them, treating them as a
single study.
3. IDENTIFICATION OF ENTRIES. The entries in this bibliography are sorted
numerically by Master Record Identifier, or "MRID number". This number is unique
to the citation, and should be used whenever a specific reference is required. It is not
related to the six-digit "Accession Number" which has been used to identify volumes of
submitted studies (see paragraph 4 (d) (4) below for further explanation). In a few
cases, entries added to the bibliography late in the review may be preceded by a nine
character temporary identifier. These entries are listed after all MRID entries. This
temporary identifying number is also to be used whenever specific reference is needed.
4. FORM OF ENTRY. In addition to the Master Record Identifier (MRID), each entry
consists of a citation containing standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known submission. Bibliographic
conventions used reflect the standard of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
a Author. Whenever the author could confidently be identified, the Agency has
chosen to show a personal author. When no individual was identified, the
Agency has shown an identifiable laboratory or testing facility as the author.
When no author or laboratory could be identified, the Agency has shown the
first submitter as the author.
b. Document date. The date of the study is taken directly from the document.
When the date is followed by a question mark, the bibliographer has deduced
the date from the evidence contained in the document. When the date appears
157
-------
as (19??), the Agency was unable to determine or estimate the date of the
document.
c. Title. In some cases, it has been necessary for the Agency bibliographers to
create or enhance a document title. Any such editorial insertions are contained
between square brackets.
d. Trailing parentheses. For studies submitted to the Agency in the past, the
trailing parentheses include (in addition to any self-explanatory text) the
following elements describing the earliest known submission:
(1) Submission date. The date of the earliest known submission appears
immediately following the word "received."
(2) Administrative number. The next element immediately following the
word "under" is the registration number, experimental use permit
number, petition number, or other administrative number associated
with the earliest known submission.
(3) Submitter. The third element is the submitter. When authorship is
defaulted to the submitter, this element is omitted.
(4) Volume Identification (Accession Numbers). The final element in the
trailing parentheses identifies the EPA accession number of the volume
in which the original submission of the study appears. The six-digit
accession number follows the symbol "CDL," which stands for
"Company Data Library." This accession number is in turn followed by
an alphabetic suffix which shows the relative position of the study within
the volume.
158
-------
BIBLIOGRAPHY
MRID
CITATION
00003503 Mobil Chemical Company (1976) Modown Herbicide Performance Report
(Upublished study received Mar 9, 1977 under 2224-EX-10; CDL:228701-AN)
00022923 Hill, E.F.; Heath, R.G.; Spann, J.W.; et al. (1975) Lethal Dietary Toxicities
of Environmental Pollutants to Birds: Special Scientific Report—Wildlife No.
191. (U.S. Dept. of the Interior, Fish and Wildlife Service, Paxtuxent Wildlife
Research Center; unpublished report)
00027203 Swabey, Y.H.; Schenk, C.F. (1963) Algicides and Aquatic Herbicides: Taste
and Odour in Water; Laboratory Studies on Fish Toxicity; Field Toxicity
Studies. By Ontario Water Resources Commission, Laboraatory Div., Biology
Branch. OWRC. (Atrazine/T38; also in unpublished submission received Oct
12, 1976 under 10065-8; submitted by Fisons Corp., Agricultural Chemicals
Div., Bedford, Mass.; CDL:226310-F)
00028002 Wellborn, T.L.; Jr. (1969) The toxicity of nine therapeutic and herbicidal
compounds to striped bass. Progessive Fish-Culturist 31:27-32. (Also In
unpublished submission received Aug 20, 1976 under 39445-1; submitted by
American Carbonyl, Inc., Tenafly, N.J.; CDL:228232-C)
00031836 Tucker, B.V.; Pratt, R.D. (1972) Overhead Irrigation with Water Containing
Diquat—Crop Residue Data. (Unpublished study received Sep 15, 1972 under
1F1101; submitted by Chevron Chemical Co., Richmond, Calif.;
CDL:090862-G)
00031841 Calderbank, A.; McKenna, R.H.; Walley, J.K. (1966) Bipyridylium
Herbicides: Feeding Clover Hay and Barley Dessicated with Diquat, to Cattle.
(Unpublished study received Sep 15, 1972 under 1F1101; submitted by
Chevron Chemical Co., Richmond, Calif.; CDL:090862-N)
00038627 Anon. (19??) Diquat. Pages 167-171, in Handbook of Herbicides. Weed
Science Society of America. (Also in unpublished submission received Jun 13,
1975 under 5E1648; submitted by Chevron Chemical Co., Richmond, Calif.;
CDL:095428-C)
00055086 Coats, G.E.; Funderburk, H.H., Jr.; Lawrence, J.M.; et al. (1966) Factors
affecting persistence and inactivation of Diquat and Paraquat. Weed Research
6(1): 58-66. (Also in unpublished submission received Apr 7, 1971 under
159
-------
BIBLIOGRAPHY
MRID
CITATION
unknown admin, no.; submitted by Chevron Chemical Co., Richmond, Calif.;
CDL:180000-B)
00056905 Funderburk, H.H., Jr. (1969) Diquat and paraquat. Pages 285-291 only, In
Degradation of Herbicides. Edited by P.C. Kearney and D.D. Kaufman.
Marcel Dekker, Inc. (Also in unpublished submission received Jun 6, 1970
under 1F1103; submitted by PPG Industries, Inc., Barberton, Ohio;
CDL:090868-K)
00061637 Palmer, A.K.; Edwards, J.A.; Woodhouse, R.N. (1978) Effect of Diquat on
Pregnancy of the Mouse: ICI/167/77642. (Unpublished study received Jan 27,
1981 under 239-1663; prepared by Huntingdon Research Centre, England,
submitted by Chevron Chemical Co., Richmond, Calif.; CDL:244244-E)
00065599 Hemingway, R.J.; Leahey, J.P.; Davis, J.A.; et al. (1973) Diquat: Metabolism
of Diquat and Its Photoproducts in Goats: AR 2448 B. (Unpublished study
received Aug 22, 1977 under 239-1663; prepared by Plant Protection Ltd.,
submitted by Chevron Chemical Co., Richmond, Calif.; CDL:231429-H)
00065600 Hemingway, R.J.; Leahey, J.P.; Davis, J.A.; et al. (1974) Diquat: Metabolism
of Diquat and Its Photoproducts in a Cow: AR 2530B (R). (Unpublished study
received Aug 22, 1977 under 239-1663; prepared by Plant Protection Ltd.,
submitted by Chevron Chemical Co., Richmond, Calif.; CDL:231429-I)
00065601 Chevron Chemical Company (1967) Environmental Chemistry Summary.
Summary of studies 231430-B through 231430-Q, 231430-S through
231430-AA, 231431-A through 231431-D and 231431-F through 231431-AA.
(Unpublished study received Aug 22, 1977 under 2391663; CDL:231430-A)
00065603 Akhavein, A.A.; Linscott, D.L. (1968) The dipyridylium herbicides, paraquat
and diquat. Residue Reviews 23:97-145. (Also In unpublished submission
received Aug 22, 1977 under 239-1663; submitted by Chevron Chemical Co.,
Richmond, Calif.; CDL:231430-C)
00065604 Calderbank, A.; Slade, P. (1976) Diquat and paraquat. In Herbicides:
Chemistry, Degradation and Mode of Action: Volume 2. Edited by P.C.
Kearney and D.D. Kaufmann. New York, N.Y.: Marcel Dekker, Inc.
(Reprint; also In unpublished submission received Aug 22, 1977 under
160
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BIBLIOGRAPHY
MRID
CITATION
239-1663; submitted by Chevron Chemical Co., Richmond, Calif.;
CDL:231430-D)
00067154 Newman, J.F. (1975) Diquat: Biological Effects and Residues in Soil and Crops
in a High Rate Field Trial on a Loamy Sand: TMJ 1225A. (Unpublished study
received Aug 22, 1977 under 239-1663; prepared by Plant Protection Ltd.,
England, submitted by Chevron Chemical Co., Richmond, Calif.;
CDL:231432-E)
00067157 Cavell, B.D. (1976) Diquat: A Review of Its Photodegradation: Report Series
TMJ 1433B. (Unpublished study received Aug 22, 1977 under 239-1663;
prepared by Imperial Chemical Industries, Ltd., England, submitted by
Chevron Chemical Co., Richmond, Calif.; CDL:231432-H)
00067162 Leahey, J.P.; Griggs, R.E.; Allard, G.B. (1973) Diquat: Residues of Diquat
and Its Photoproducts on Barley and Oats after Desiccation with 14-C Diquat:
AR 2478B. (Unpublished study received Aug 22, 1977 under 239-1663;
prepared by Plant Protection Ltd., England, submitted by Chevron Chemical
Co., Richmond, Calif.; CDL:231432-M)
00068221 Hill, I.R. (1975) Diquat: Degradation of Diquat and Its Photoproducts in Soil:
AR 2573A. (Unpublished study received Aug 22, 1977 under 239-1663;
prepared by Plant Protection Ltd., submitted by Chevron Chemical Co.,
Richmond, Calif.; CDL:231431-B)
00068225 Blackburn, R.D.; Weldon, L.W. (1963) Results of 3 years of testing diquat as
an aquatic herbicide in Florida. Proceedings of the Southern Weed Control
Conference 16:365. (Abstract; also in unpublished submission received Aug
22, 1977 under 239-1663; submitted by Chevron Chemical Co., Richmond,
Calif.; CDL: 231431-H)
00068226 Coats, G.E.; Funderburk, H.H., Jr.; Lawrence, J.M.; et al. (1964) Persistence
of diquat and paraquat in pools and ponds. Proceedings of the Southern Weed
Control Conference 17:308-320. (Also in unpublished submission received Aug
22, 1977 under 2391663; submitted by Chevron Chemical Co., Richmond,
Calif.; CDL: 231431-J)
00068228 Haven, D.S. (1969) Levels of the herbicide diquat in two estuarine molluscs
and in the water and mud. Virginia Journal of Science 20:51-53. (Also In
161
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BIBLIOGRAPHY
MRID
CITATION
unpublished submission received Aug 22, 1977 under 239-1663; submitted by
Chevron Chemical Co., Richmond, Calif.; CDL:231431-N)
00068229 Hiltibran, R.C.; Underwood, D.L.; Fickle, J.S. (1972) Fate of Diquat in the
Aquatic Environment: WRC Research Report No. 52. Final rept. (Unpublished
study received Aug 22, 1977 under 239-1663; prepared by Univ. of Illinois,
Dept. of Agronomy, Water Resources Center, submitted by Chevron Chemical
Co., Richmond, Calif.; CDL:231431-0)
00071325 Plant Protection Limited (1972) Determination of Residues of Diquat in Crops
and Animal Tissues: Spectrophotometric Method. Method PPRAM-5 dated
Dec 6, 1972. (Unpublished study received Jan 27, 1981 under 239-1663;
submitted by Chevron Chemical Co., Richmond, Calif.; CDL:244243-B)
00071326 Plant Protection Limited (1972) Determination of Residues of Diquat in Milk
and Water: Spectrophotometric Method. Method PPRAM-7 dated Dec 6,
1972. (Unpublished study received Jan 27, 1981 under 239-1663; submitted by
Chevron Chemical Co., Richmond, Calif.; CDL:244243-C)
00081506 Rittenhouse, J.R. (1979) The Acute Oral Toxicity of Diquat Water Weed
Killer: SOCAL 1396/37:67 (S-1431). (Unpublished study received Sep 14,
1979 under 239-2247; submitted by Chevron Chemical Co., Richmond, Calif.;
CDL:098973-B)
00100410 Chevron Chemical Co. (1971) Residue Data Sheet: Sugar Cane. (Compilation;
unpublished study received Jul 11, 1972 under unknown admin, no.;
CDL:120274-A)
00106559 Fink, R.; Beavers, J.; Joiner, G.; et al. (1982) Final Report: Acute Oral
LD50-Mallard Duck: Diquat Technical (SX-1260): Project No. 162-131. Rev.
(Unpublished study received May 13, 1982 under 239-1663; prepared by
Wildlife International Ltd. and Washington College, submitted by Chevron
Chemical Co., Richmond, CA; CDL:247503-A)
00114230 Fink, R.; Beavers, J.; Joiner, G.; et al. (1982) One-generation
Reproduction—Mallard Duck: Diquat Technical (SX-1306): Project No.
162-143; S-2069. Final rept. (Unpublished study received Sep 3, 1982 under
239-1663; prepared by Wildlife International Ltd., submitted by Chevron
Chemical Co., Richmond, CA; CDL: 248290-D)
162
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BIBLIOGRAPHY
MRID
CITATION
00114449 Chevron Chemical Co. (1961) Determination of Residues of Diquat and
Paraquat in Various Crops. (Compilation; unpublished study received May 13,
1963 under unknown admin, no.; CDL:124104-A)
00115546 Chevron Chemical Co. (1961) Analyses for Residues of Diquat in Plant
Tissues. (Compilation; unpublished study received Aug 11, 1961 under
239-1663; CDL:001351-B)
00115547 Chevron Chemical Co. (1970) Diquat: The Results of Tests on the Amount of
Residue Remaining, Including a Description of the Analytical Methods Used.
(Compilation; unpublished study received Dec 12, 1970 under 1F1101;
CDL:090861-A)
00115549 Chevron Chemical Co. (1964?) Photochemical Decomposition of
Diquatldentification of the Degradation Product on Maize. (Unpublished study
received on unknown date under 7F0594; CDL:092883-E)
00115555 Chevron Chemical Co. (19??) Name, Chemical Identity and Composition of the
Pesticide Chemical: Diquat. (Compilation; unpublished study received Sep 14,
1979 under 239-2247; CDL:098968-A)
00115563 Homer, R.; Morgan, C.; Stubbs, J.; et al. (1959) Dipyridylium Quarternary
Salts: Residues in Potato Tubers after Foliar Application of 14-C Labelled
K8483: Experimental Report No. PP/ E/ll. (Unpublished study received Jun
20, 1963 under unknown admin, no.; prepared by Imperial Chemical
Industries, Ltd., submitted by Chevron Chemical Co., Richmond, CA;
CDL:120267-E)
00115572 McCann, J. (1967) Diquat/Dibromide: Bluegill (Lepomis macrochirus): Test
No. 54. (U.S. Agricultural Research Service, Pesticides Regulation Div.,
Animal Biology Laboratory; unpublished study; CDL:132049-A)
00115575 Chevron Chemical Co. (1961) Analyses for Residues of Diquat in Castor
Beans, Sorghum and Soybeans. (Compilation; unpublished study received Jun
15, 1961 under 239-2247; CDL:224725-B)
00115576 Wheeler, R. (1978) 48 Hour Acute Static Toxicity of Diquat Dibromide
(SX958) to 1st Stage Nymph Water Fleas (Daphnia magna Straus).
163
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BIBLIOGRAPHY
MRID
CITATION
(Unpublished study received Sep 15, 1978 under 2391663; submitted by
Chevron Chemical Co., Richmond, CA; CDL: 235179-A)
00115583 Slade, P.; Calderbank, A. (1966) Bipyridylium Herbicides: The Degradation of
Diquat after Its Application to Plants: Central File No. A126,360.
(Unpublished study received Aug 22, 1977 under 239-1663; prepared by
Imperial Chemical Industries, Ltd., submitted by Chevron Chemical Co.,
Richmond, CA; CDL:231428-P)
00115858 Simonin, H.; Skea, J. (1977) Toxicity of diquat and cutrine to fingerling brown
trout. New York Fish and Game Journal 24(1): 37-45. (Also in unpublished
submission received Sep 14, 1979 under 239-2247; submitted by Chevron
Chemical Co., Richmond, CA; CDL:098974-C)
00115862 Nicholson, S.; Clerman, R. (1974) Toxicity of diquat to the crustacean
amphipod hyalella from Chautauqua Lake. Environmental Letters
7(3):215-227. (Also in unpublished submission received Sep 14, 1979 under
239-2247; submitted by Chevron Chemical Co., Richmond, CA;
CDL:098974-N)
00116565 Fink, R.; Beavers, J.; Joiner, G.; et al. (1981) Subacute Feeding-Reproduction
Screening Bioassay—Bobwhite Quail: Diquat Technical (SX-1306): Project No.
162-137; S-1984. Final rept. (Unpublished study received Sep 3, 1982 under
239-1663; prepared by Wildlife International Ltd., submitted by Chevron
Chemical Co., Richmond, CA; CDL:248290-B)
00116728 Chevron Chemical Co. (1978) Diquat 2 Spray—Potatoes. (Compilation;
unpublished study received Sep 14, 1979 under 239-2247; CDL:098975-A;
098970)
00116736 Great Lakes Chemical Corp. (1970) Analyses for Residues of Bromine and
Other Chemicals in Various Products. (Compilation; unpublished study
received on unknown date under unknown admin, no.; CDL:127345-A)
00116739 Chevron Chemical Co. (1977) Residue Chemistry Data and Data Reference List
To Support Label Amendment for Diquat Water Weed Killer. (Compilation;
unpublished study received Aug 22, 1977 under 239-1663; CDL:231427-A)
164
-------
BIBLIOGRAPHY
MRID
CITATION
00119988 Fink, R.; Beavers, J.; Joiner, G.; et al. (1982) One-generation
Reproduction—Bobwhite Quail: Diquat Technical (SX-1306): Project No.
162-142; S-2070. Final rept. (Unpublished study received Sep 3, 1982 under
239-1663; prepared by Wildlife International Ltd., submitted by Chevron
Chemical Co., Richmond, CA; CDL:248290-C)
00121305 Akhavein, A.; Linscott, D. (1968) The dipyridylium herbicides, paraquat and
diquat. Residue Reviews 23:98-145. (Also in unpublished submission received
Dec 21, 1982 under 239-2247; submitted by Chevron Chemical Co.,
Richmond, CA; CDL:249102-C)
00121307 Simsiman, G.; Daniel, T.; Chesters, G. (1976) Diquat and endothall: Their
fates in the environment. Residue Reviews 62:131-174. (Also in unpublished
submission received Dec 21, 1982 under 2392247; submitted by Chevron
Chemical Co., Richmond, CA; CDL: 249102-E)
00131562 Atkins, E. (1983) Letter sent to T. Wang dated March 14, 1983 Testing
252,214 against honey bees. (Unpublished study received October 14, 1983
under 241-EX-108; prepared by University of California, Riverside, Dept. of
Entomology, submitted by American Cyanamid Co., Princeton, NJ:
CDL:072012-J)
00138962 Thompson, C.; Griffen, J.; McKee, M. (1980) Acute Toxicity of Diquat 2
Spray (SX-1261) to Bluegill Sunfish: ABC Report #26193; S-1835.
(Unpublished study received Feb 6, 1984 under 239-2424; prepared by
Analytical Bio-Chemistry Laboratories, Inc., submitted by Chevron Chemical
Co., Richmond, CA; CDL: 252355-B)
00138928 McAllister, W.; Franklin, L.; Cohle, P.; et al. (1984) Uptake, Depuration and
Bioconcentration of 14C-R-40244 by Bluegill Sunfish (Lepomis macrochirus):
ABC Final Report #30973; T-11414. (Unpublished study received Feb 1, 1984
under 476-EX-104; prepared by Analytical Bio-Chemistry Laboratories, Inc.,
submitted by Stauffer Chemical Co., Richmond, CA; CDL:252340-A)
00138961 Thompson, C.; Griffen, J.; Forbis, A. (1980) Acute Toxicity of Diquat 2
Spray (SX-1261) to Rainbow Trout: ABC Report #26194; S-1834.
(Unpublished study received Feb 6, 1984 under 239-2424; prepared by
Analytical Bio-Chemistry Laboratories, Inc., submitted by Chevron Chemical
Co., Richmond, CA; CDL: 252355-A)
165
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BIBLIOGRAPHY
MRID
CITATION
00138963 Johnson, W., Finley, M. (1980) Handbook of Acute Toxicity of Chemicals to
Fish and Aquatic Invertebrates. By U.S. Fish and Wildlife Service.
Washington, D.C.: USFWS. (Resource publication 137: also in unpublished
submission by Chevron Chemical Co., Richmond, CA; CDL: 252355-C)
00135717 Chevron Chemical Co. (1970) Diquat: Residue Tolerance Petition: The Results
of Tests on the Amount of Residue Remaining, Including a Description of the
Analytical Methods Used: Water, Aquatic Life and Soil. (Compilation;
unpublished study received Dec 12, 1970 under 1F1101; CDL:090861-A)
00136329 Chevron Chemical Co. (19??) The Name, Chemical Identity and Composition
of the Pesticide Chemical: Diquat. (Unpublished study received Jun 29, 1976
under 239-EX-66; CDL:097462-A)
00136507 Chevron Chemical Co. (1971) Residue of Diquat in Sugarcane. (Compilation;
unpublished study received Jul 11, 1972 under 2391663; CDL:001360-B)
00138938 Chevron Chemical Co. (1984) Product Chemistry Data Requirements: Ortho
Diquat Herbicide Concentrate. (Unpublished study received Feb 2, 1984 under
239-2424; CDL:252345-A)
00138961 Thompson, C.; Griffen, J.; Forbis, A. (1980) Acute Toxicity of Diquat 2 Spray
(SX-1261) to Rainbow Trout: ABC Report #26194; S-1834. (Unpublished
study received Feb 6, 1984 under 239-2424; prepared by Analytical
Bio-Chemistry Laboratories, Inc., submitted by Chevron Chemical Co.,
Richmond, CA; CDL: 252355-A)
00138962 Thompson, C.; Griffen, J.; McKee, M. (1980) Acute Toxicity of Diquat 2
Spray (SX-1261) to Bluegill Sunfish: ABC Report #26193; S-1835.
(Unpublished study received Feb 6, 1984 under 239-2424; prepared by
Analytical Bio-Chemistry Laboratories, Inc., submitted by Chevron Chemical
Co., Richmond, CA; CDL: 252355-B)
00140582 Black, W.; Calderbank, A.; Douglas, G.; et al. (1966?) Silage Feeding
Experiments following the Use of Diquat as a Desiccant. (Unpublished study
received on unknown date under 7F0594; submitted by Chevron Chemical Co.,
Richmond, CA; CDL:092882-0)
166
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BIBLIOGRAPHY
MRID
CITATION
00140586 Chevron Chemical Co. (1967) Diquat: The Results of Tests on the Amount of
Residue Remaining, Including a Description of the Analytical Method Used.
(Compilation; unpublished study received 1967 under 7F0594; CDL:092882-S)
00140590 Chevron Chemical Co. (1974) Diquat: The Results of Tests on the Amount of
Residue Remaining, Including a Description of the Analytical Methods Used.
(Compilation; unpublished study received Feb 15, 1974 under 4G1470;
CDL:093914-D)
00145855 Colley, J.; Warren, S.; Heywood, R. (1985) Diquat Dibromide Evaluation of
Potential Carcinogenicity and Chronic Toxicity by Prolonged Dietary
Administration to Rats: Final Report: HRC Report No. ICI 406-83763.
Unpublished study prepared by Huntingdon Research Centre. 2660 p.
00155474 Birtley, R. (19??) Amended Page to Replace Pages 145 and 146 of the Report
Entitled Diquat Dibromide: Evaluation of Potential Carcinogenicity and
Chronic Toxicity by Prolonged Dietary Administration to Rats: HRC Report
No. ICI 406/83763. Unpublished study prepared by Chevron Chemical Co. 2
P-
40069304 Hart, T. (1987) Physicochemical Data: Diquat: Laboratory Project
Identification: 8701235. Unpublished study prepared by ICI PPD. 5 p.
40165101 Shilling, D. (1987) The Influence of Preemergence Applied Diquat in the
Germination and Emergence of Selected Plant Species: Laboratory Project ID:
8704721. Unpublished study prepared by Univ. of Florida, Derpt. of
Agronomy, lip.
40165102 Hulbert, J. (1987) Evaluation of Diquat for Vegetative Vigor and Growth:
Laboratory Project ID: 1692-22. Unpublished compilation prepared by Chevron
Chemical Co. 18 p.
40165103 Johnson, L. (1962) Evaluation of Diquat for Field Tests of Herbicides:
Laboratory Project ID: #87022-C and #87025-C. Unpublished study prepared
by Research and Planning Div., Wisconsin Conservation Dept. 9 p.
40165104 Blackburn, R.; Weldon, L. (1965) The Sensitivity of Duckweeds (Lemnaceae)
and Azolla to Diquat and Paraquat: Laboratory Project ID: #87022-C and
167
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BIBLIOGRAPHY
MRID
CITATION
#87025-C. Unpublished study prepared by U.S. Agricultural Research Service,
Fort Lauderdale, Florida. 5 p.
40165105 Hulbert, J. (1987) Evaluation of Diquat for Reproduction of Aquatic Plants:
Laboratory Project ID: #87022-C and #87025-C. Unpublished study prepared
by Chevron Chemical Co. 15 p.
40185601 Colley, J.; Edmonson, J.; Heywood, R. (1981) Diquat Dibromide: Preliminary
Assessment of Toxicity to Rats by Dietary Administration for 4 Weeks: Final
Report: Laboratory Project ID: ICI 3837 80935. Unpublished study prepared
by Huntingdon Research Centre. 173 p.
40208001 Gough, H.; Collins, I.; Jackson, D.; et al. (1987) Diquat: Acute 5-day Contact
and Oral Toxicity to Honey Bees (Apis mellifera): Laboratory Project ID:
RJ055B. Unpublished study prepared by Imperial Chemicals Industries. 39 p.
40245101 Pack, E. (1987) Diquat Volatility-Laboratory Study: Laboratory Project
Identification MEF-0045: 8709311. Unpublished study prepared by Chevron
Chemical Co. 97 p.
40246101 Joseph, R.; Skidmore, M. (1987) Diquat: Photolytic Stability on Soil Surfaces:
Lab Project ID: RJ0573B. Unpublished study prepared by ICI Agricultural
Experiment Station. 50 p.
40302701 Thornberry, N. (1987) Physical and Chemical Characteristics: Ortho Diquat
Concentrate: Laboratory Project ID: 8711137. Unpublished study prepared by
Chevron Chemical Co. & Imperial Chemicals Industries. 3 p.
40315701 Hoberg, J. (1987) Acute Toxicity of Diquat Concentrate to Mysid Shrimp
(Mysidopsis bahia): Laboratory Project Identification: S-2910:
981.0287.6111.510. Unpublished study prepared by Springborn Life Sciences,
Inc. 52 p.
40316001 Dionne, E. (1987) Acute Toxicity of Diquat Concentrate to Eastern Oysters
(Crassostrea virginica): Springborn Life Sciences: 981. 0287.6112.504.
Unpublished study prepared by Springborn Life Sciences, Inc. 51 p.
168
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BIBLIOGRAPHY
MRID
CITATION
40323601 Thornberry, N. (1987) Analysis and Certification of Product Ingredients: Ortho
Diquat Concentrate: Laboratory Project ID: 8715953. Unpublished study
prepared by Chevron Chemical Co., Imperial Chemical Industries. 50 p.
40326901 Hamer, M.; Farrelly, E.; Hill, I. (1987) Diquat: Investigation of Accumulation
in Bluegill Sunfish in a Flow-through System: Lab. Proj. ID RJ0608B.
Unpublished study prepared by Imperial Chemical Industries, PLC. 33 p.
40326902 Thompson, R. (1987) Diquat: Determination of Bioconcentration by Pacific
Oysters (Crassostrea gigas): BL/B/3092. Unpublished study prepared by
Imperial Chemical Industries, Ltd. 23 p.
40326903 Hamer, M.; Farrelly, E.; Hill, I. (1987) Diquat: Investigation of Accumulation
in Daphnia magna in a Flow-through System: Lab. Proj. ID RJ0584B.
Unpublished study prepared by Imperial Chemical Industries, Ltd. 31 p.
40326904 Fujie, G. (1987) Accumulation of Diquat in Aquatic Non-Target Organisms:
Lab.Proj. ID R-101655INT: Interim Report. Unpublished study prepared by
Chevron Chemical Co. 92 p.
40335201 Cole, J.; Laws, I.; Stevens, J.; et al. (1986) Long-term High-rate Trial
Frensham, U.K.: Crop and Soil Data for the Period 8-14 Years after
Treatment: Laboratory Project ID: RJ0481B. Unpublished study prepared by
ICI Plant Protection Div., Jealott's Hill Research Station. 50 p.
40348601 Pack, D. (1987) Freundlich Soil Adsorption Coefficients of Diquat: Laboratory
Project I.D: MEF-0069/8716930. Unpublished study prepared by Chevron
Chemical Co. 41 p.
40380701 Hamer, M.; Farrelly, E.; Hill, I. (1987) Diquat: Investigation of Accumulation
and Elimination in Mayfly Nymph, Cloen dipterum, in a Flow-through System:
Lab. Proj. ID. RJ0609B. Unpublished Study prepared by Imperial Chemical
Industries. 29 p.
40380702 Surprenant, D. (1987) The Chronic Toxicity of Diquat Cone, to Daphnia
magna under Flow-through Conditions: Lab. Proj. ID. 87-82473. Unpublished
study prepared by Springborn Life Sciences, Inc. 67 p.
169
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BIBLIOGRAPHY
MRID
CITATION
40380703 Surprenant, D. (1987) The Toxicity od Diquat Cone, to Fathead Minnow
(Pimephales promelas) Embryo and Larvae. Unpublished study prepared by
Springborn Life Sciences, Inc. 64 p.
40418801 Tegala, B.; Skidmore, M. (1987) Diquat: An Aqueous Photolysis Study:
Laboratory Project ID: RJ 0613B. Unpublished study prepared by Imperial
Chemical Industries, PLC. 54 p.
40427601 Fujie, G. (1987) Magnitude of the Residues of Diquat in Fish and Shellfish:
Laboratory Project ID: RIO/9816121. Unpublished study prepared by Chevron
Chemical Co. 162 p.
40429601 Updyke, J. (1987) Determination of Ethylene Dibromide: (EDB in Diquat
Liquid AM-5-1285): Laboratory Project ID: 8725759. Unpublished study
prepared by Chevron Chemical Co. 9 p.
40458300 Chevron Chemical Co. (1987) Submission of Field Accumulation Study to
Support the Registration of Ortho Diquat Cone. Transmittal of 1 study.
40458301 Fujie, G. (1987) Accumulation of Diquat in Aquatic Non-target Organisms:
Lab. Proj. ID. R10/1655FISH. Unpublished study prepared by Chevron
Chemical Co. 117 p.
40535901 Fujie, G. (1988) Magnitude of Diquat Cation Residues in Alfalfa Seed: Project
ID: ROlO/Alfalfa. Unpublished study prepared by Chevron Chemical Co. 62
P-
40535902 Fujie, G. (1988) Magnitude of Diquat Cation Residues in Clover Seed: Project
ID: ROlO/Clover. Unpublished study prepared by Chevron Chemical Co. 69
P-
40535903 Fujie, G. (1988) Magnitude of Diquat Cation Residues in Grain Sorghum:
Project ID: ROlO/Sorghum. Unpublished study prepared by Chevron Chemical
Co. 49 p.
40535904 Fujie, G. (1988) Magnitude of Diquat Cation Residues in Soybeans: Project ID:
ROlO/Soybeans. Unpublished study prepared by Chevron Chemical Co. 77 p.
170
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BIBLIOGRAPHY
MRID
CITATION
40535905 Fujie, G. (1988) Magnitude of Diquat Cation Residues in Rice: Project ID:
ROlO/Rice. Unpublished study prepared by Chevron Chemical Co. 75 p.
40640801 Bruce, E.; Griffis, L. (1987) Three-Week Satellite Aerosol Inhalation Toxicity
Study of Diquat Concentrate (SX-1750) in Rats: Supplement: Project ID:
CEHC 2835. Unpublished study S-2908S prepared by Chevron Environmental
Health Center, Inc. 148 p.
40811101 Updyke, J. (1988) Supplement to Stability of Ethylene Dibromide (EDB) in
Diquat Herbicide H/A. Submitted November 30, 1987: Laboratory Project ID
8816196. Unpublished study prepared by Chevron Chemical Co. 4 p.
40811102 Fujie, G. (1988) Effect of Processing on Diquat Cation Residues in Soybeans:
Laboratory Project ID R010/SOYPROC. Unpublished study prepared by
Chevron Chemical Co. 70 p.
40811103 Fujie, G. (1988) Effect of Processing on Diquat Cation Residues in Grain
Sorghum: Laboratory Project ID R010/SORGPROC. Unpublished study
prepared by Chevron Chemical Co. 75 p.
40917403 Fujie, G. (1988) Aquatic Field Dissipation Studies for Aquatic Uses and
Aquatic Impact Uses: Laboratory Project ID: R10/1642AQDISS. Unpublished
study prepared by Chevron Chemical Co. 183 p.
40927601 Johnston, J. (1988) Aerobic Aquatic Metabolism of Diquat: Laboratory Project
ID MEF-0073. Unpublished study prepared by Chevron Chemical Co. 116 p.
40972301 Johnston, J. (1988) Aerobic Soil Metabolism of Diquat: Project ID: MEF-0071.
Unpublished study prepared by Chevron Chemical Co. 116 p.
40972302 Johnston, J. (1988) Anaerobic Aquatic Metabolism of Diquat: Project ID:
MEF-0072. Unpublished study prepared by Chevron Chemical Co. 129 p.
41198902 Wickramaratne, G. (1989) Diquat: Teratogenicity Study in the Rat: Report No.
CTL/P/2331: Study No. RR0399. Unpublished study prepared by ICI Central
Toxicology Laboratory. 394 p.
171
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BIBLIOGRAPHY
MRID
CITATION
41883001 Bellet, E. (1990) Effect of Diquat on Terrestrial Plants A Tier 3 Study: Lab
Project Number: DQ 124-1. Unpublished study prepared by Chevron Chemical
Co. 114 p.
41883002 Bellet. E. (1990) Effect of Diquat on Aquatic Plants-A Tier 3 Study: Lab
Project Number: DQ 124-2. Unpublished study prepared by Chevron Chemical
Co.272 p.
42060301 Fujie, G. (1991) Diquat Cation Soil Dissipation Study on Potatoes in New
York: Supplement to: Lab Project Number: R010/7059SOILF. Data submitted
as alternate to Craven Laboratories generated data. Unpublished study prepared
by A&S Environmental Testing, Inc. 465 p.
42060302 Fujie, G. (1991) Diquat Cation Soil Dissipation Study on Potatoes in Idaho:
Supplement to: Lab Project Number: R010/7060SOILF. Data submitted as
alternate to Craven Laboratories generated data. Unpublished study prepared
by A&S Environmental Testing, Inc. 320 p.
42822001 Fujie, G. (1993) Addendum to: Magnitude of Diquat Cation Residues in Clover
Seed: Lab Project Number: R010/CLOVER/A. Unpublished study prepared by
Chevron Chemical Co. 254 p.
42822002 Fujie, G. (1993) Addendum to: Magnitude of Diquat Cation Residues in Alfalfa
Seed: Lab Project Number: R010/ALFALFA/A. Unpublished study prepared
by Chevron Chemical Co. 220 p.
172
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APPENDIX D. List of Available Related Documents
173
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174
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The following is a list of available documents related to Diquat Dibromide. It's
purpose is to provide a path to more detailed information if it is needed. These accompanying
documents are part of the Administrative Record for Diquat Dibromide and are included in the
EPA's Office of Pesticide Programs Public Docket.
1. Health and Environmental Effects Science Chapters
2. Detailed Label Usage Information System (LUIS) Report
3. Diquat Dibromide RED Fact Sheet
4. PR Notice 86-5 (included in this appendix)
5. PR Notice 91-2 (included in this appendix) pertains to the Label Ingredient
Statement
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176
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APPENDIX E. PR Notices 86-5 and 91-2
177
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178
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PR Notice 86-5
179
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180
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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
tPROl WASHINGTON, D.C. 20460
July 29, 1986
OFFICE OF
PR NOTICE 86-5 PREVENTION, PESTICIDES
AND TOXIC SUBSTANCES
NOTICE TO PRODUCERS, FORMULATORS, DISTRIBUTORS
AND REGISTRANTS
Attention: Persons responsible for Federal registration of pesticides.
Subject: Standard format for data submitted under the Federal Insecticide,
Fungicide, and Rodenticide Act (FIFRA) and certain provisions of the
Federal Food, Drug, and Cosmetic Act (FFDCA).
I. Purpose
To require data to be submitted to the Environmental Protection Agency (EPA) in a
standard format. This Notice also provides additional guidance about, and illustrations of, the
required formats.
II. Applicability
This PR Notice applies to all data that are submitted to EPA to satisfy data
requirements for granting or maintaining pesticide registrations, experimental use permits,
tolerances, and related approvals under certain provisions of FIFRA and FFDCA. These data
are defined in FIFRA §10(d)(l). This Notice does not apply to commercial, financial, or
production information, which are, and must continue to be, submitted differently under
separate cover.
III. Effective Date
This notice is effective on November 1, 1986. Data formatted according to this notice
may be submitted prior to the effective date. As of the effective date, submitted data packages
that do not conform to these requirements may be returned to the submitter for necessary
revision.
IV. Background
On September 26, 1984, EPA published proposed regulations in the Federal Register
(49 FR 37956) which include Requirements for Data Submission (40 CFR §158.32), and
Procedures for Claims of Confidentiality of Data (40 CFR §158.33). These regulations
specify the format for data submitted to EPA under Section 3 of FIFRA and Sections 408 and
4139 of FFDCA, and procedures which must be followed to make and substantiate claims of
confidentiality. No entitlements to data confidentiality are changed, either by the proposed
regulation or by this notice.
OPP is making these requirements mandatory through this Notice to gain resource-
saving benefits from their use before the entire proposed regulation becomes final. Adequate
lead time is being provided for submitters to comply with the new requirements.
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V. Relationship of this Notice to Other OPP Policy and Guidance
While this Notice contains requirements for organizing and formatting submittals of
supporting data, it does not address the substance of test reports themselves. "Data reporting"
guidance is now under development in OPP, and will specify how the study objectives,
protocol, observations, findings, and conclusions are organized and presented within the study
report. The data reporting guidance will be compatible with submittal format requirements
described in this Notice.
OPP has also promulgated a policy (PR Notice 86-4 dated April 15, 1986) that
provides for early screening of certain applications for registration under FIFRA §3. The
objective of the screen is to avoid the additional costs and prolonged delays associated with
handling significantly incomplete application packages. As of the effective date of this Notice,
the screen will include in its criteria for acceptance of application packages the data formatting
requirements described herein.
OPP has also established a public docket which imposes deadlines for inserting into the
docket documents submitted in connection with Special Reviews and Registration Standards
(see 40 CFR §154.15 and §155.32). To meet these deadlines, OPP is requiring an additional
copy of any data submitted to the docket. Please refer to Page 10 for more information about
this requirement.
For several years, OPP has required that each application for registration or other
action include a list of all applicable data requirements and an indication of how each is
satisfied—the statement of the method of support for the application. Typically, many
requirements are satisfied by reference to data previously submitted—either by the applicant or
by another party. That requirement is not altered by this notice, which applies only to data
submitted with an application.
VI. Format Requirements
A more detailed discussion of these format requirements follows the index on the next
page, and samples of some of the requirements are attached. Except for the language of the
two alternative forms of the Statement of Data Confidentiality Claims (shown in Attachment 3)
which cannot be altered, these samples are illustrative. As long as the required information is
included and clearly identifiable, the form of the samples may be altered to reflect the
submitter's preference.
- INDEX-
Text Example
Page Page
A. Organization of the Submittal Package 3 17
B. Transmittal Document 4 11
C. Individual Studies 4
C. 1 Special Considerations for Identifying Studies 5
D. Organization of each Study Volume 6 17
D. 1 Study Title Page 7 12
D. 2 Statement of Data Confidentiality Claims
(based on FIFRA §10(d)(l)) 8 13
D. 3 Confidential Attachment 8 15
D. 4 Supplemental Statement of Data Confidentiality
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Claims (other than those based on FIFRA §10(d)(l)) 8 14
D. 5 Good Laboratory Practice Compliance Statement 9 16
E. Reference to Previously Submitted Data 9
F. Physical Format Requirements & Number of Copies 9
G. Special Requirements for Submitting Data to the Docket 10
A. Organization of Submittal Package
A "submittal package" consists of all studies submitted at the same time for review in
support of a single regulatory action, along with a transmittal document and other related
administrative material (e.g. the method of support statement, EPA Forms 8570-1, 8570-4,
8570-20, etc.) as appropriate.
Data submitters must organize each submittal package as described in this Notice. The
transmittal and any other administrative material must be grouped together in the first physical
volume. Each study included in the submittal package must then be bound separately.
Submitters sometimes provide additional materials that are intended to clarify,
emphasize, or otherwise comment to help Product Managers and reviewers better understand
the submittal.
- If such materials relate to one study, they should be included as an appendix to that
study.
- If such materials relate to more than one study (as for example a summary of all
studies in a discipline) or to the submittal in general, they must be included in the
submittal package as a separate study (with title page and statement of confidentiality
claims).
B. Transmittal Document
The first item in each submittal package must be a transmittal document. This
document identifies the submitter or all joint submitters; the regulatory action in support of
which the package is being submitted--i.e., a registration application, petition, experimental
use permit (EUP), §3(c)(2j(B) data call-in, §6(aj(2) submittal, or a special review; the
transmittal date; and a list of all individual studies included in the package in the order of their
appearance, showing (usually by Guideline reference number) the data requirement(s)
addressed by each one. The EPA-assigned number for the regulatory action (e.g. the
registration, EUP, or tolerance petition number) should be included in the transmittal
document as well, if it is known to the submitter. See Attachment 1 for an example of an
acceptable transmittal document.
The list of included studies in the transmittal of a data submittal package supporting a
registration application should be subdivided by discipline, reflecting the order in which data
requirements appear in 40 CFR 158.
The list of included studies in the transmittal of a data submittal package supporting a
petition for tolerance or an application for an EUP should be subdivided into sections A, B,
C,.... of the petition or application, as defined in 40 CFR 180.7 and 158.125, (petitions) or
Pesticide Assessment Guidelines, Subdivision I (EUPs) as appropriate.
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When a submittal package supports a tolerance petition and an application for a
registration or an EUP, list the petition studies first, then the balance or the studies. Within
these two groups of studies follow the instructions above.
C. Individual Studies
A study is the report of a single scientific investigation, including all supporting
analyses required for logical completeness. A study should be identifiable and distinguishable
by a conventional bibliographic citation including author, date, and title. Studies generally
correspond in scope to a single Guideline requirement for supporting data, with some
exceptions discussed in section C.I. Each study included in a submittal package must be
bound as a separate entity. (See comments on binding studies on page 9.)
Each study must be consecutively paginated, beginning from the title page as page 1.
The total number of pages in the com-plete study must be shown on the study title page. In
addition (to ensure that inadvertently separated pages can be reassociated with the proper study
during handling or review) use either of the following:
- Include the total number of pages in the complete study on each page (i.e., 1 of 250,
2 of 250, ...250 of 250).
- Include a company name or mark and study number on each page of the study, e g ,
Company Name-1986-23. Never reuse a study number for marking the pages of
subsequent studies.
When a single study is extremely long, binding it in mul-tiple volumes is permissible
so long as the entire study is pag-inated in a single series, and each volume is plainly identified
by the study title and its position in the multi-volume sequence.
C.I Special Considerations for Identifying Studies
Some studies raise special problems in study identification, because they address
Guidelines of broader than normal scope or for other reasons.
a. Safety Studies. Several Guidelines require testing for safety in more than one
species. In these cases each species tested should be reported as a separate study, and bound
separately.
Extensive supplemental reports of pathology reviews, feed analyses, historical control
data, and the like are often associated with safety studies. Whenever possible these should be
submitted with primary reports of the study, and bound with the primary study as appendices.
When such supplemental reports are submitted independently of the primary report, take care
to fully identify the primary report to which they pertain.
Batteries of acute toxicity tests, performed on the same end use product and covered by
a single title page, may be bound together and reported as a single study.
b. Product Chemistry Studies. All product chemistry data within a submittal package
submitted in support of an end-use product produced from registered manufacturing-use
products should be bound as a single study under a single title page.
Product chemistry data submitted in support of a technical product, other
manufacturing-use product, an experimental use permit, an import tolerance petition, or an
end-use product produced from unregistered source ingredients, should be bound as a single
study for each Guideline series (61, 62, and 63) for conventional pesticides, or for the
equivalent subject range for biorational pesticides. The first of the three studies in a complete
product chemistry submittal for a biochemical pesticide would cover Guidelines 151-10,
151-11, and 151-12; the second would cover Guidelines 151-13, 151-15, and 151-16; the third
would cover Guideline 151-17. The first study for a microbial pesticide would cover
Guidelines 151-20, 151-21, and 151-22; the second would cover Guidelines 151-23 and
151-25; the third would cover Guideline 151-26.
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Note particularly that product chemistry studies are likely to contain Confidential
Business Information as defined in FIFRA §10(d)(l)(A), (B), or (C), and if so must be
handled as described in section D.3. of this notice.
c. Residue Chemistry Studies. Guidelines 171-4, 153-3, and 153-4 are extremely
broad in scope; studies addressing residue chemistry requirements must thus be defined at a
level below that of the Guideline code. The general principle, however, of limiting a study to
the report of a single investigation still applies fully. Data should be treated as a single study
and bound separately for each analytical method, each report of the nature of the residue in a
single crop or animal species, and for each report of the magnitude of residues resulting from
treatment of a single crop or from processing a single crop. When more than one commodity
is derived from a single crop (such as beet tops and beet roots) residue data on all such
commodities should be reported as a single study. When multiple field trials are associated
with a single crop, all such trials should be reported as a single study.
D. Organization of Each Study Volume
Each complete study must include all applicable elements in the list below, in the order
indicated. (Also see Page 17.) Several of these elements are further explained in the following
paragraphs. Entries in the column headed "example" cite the page number of this notice
where the element is illustrated.
Element
Study Title Page
Statement of Data
Confidentiality
Claims
Certification of Good
Laboratory Practice
Flagging statements
Body of Study
Study Appendices
Cover Sheet to Confi-
dential Attachment
When Required
Always
One of the two alternative
forms of this statement
is always required
If study reports laboratory
work subject to GLP require-
ments
For certain toxicology studies (When
flagging requirements are finalized.)
Always - with an English language
translation if required.
At submitter's option
If CBI is claimed under FIFRA
, (B),or(C)
Example
Page 12
Page 13
Page 16
CBI Attachment
Supplemental Statement
of Data Confidentiality
Claims
If CBI is claimed under FIFRA
(B),or©
Only if confidentiality is
claimed on a basis other than
FIFRA§10(d)(l)(A), (B), or (C)
Page 15
Page 14
D.I. Title Page
A title page is always required for each submitted study, published or unpublished.
The title page must always be freely releasable to requestors; DO NOT INCLUDE CBI ON
THE TITLE PAGE. An example of an acceptable title page is on page 12 of this notice.
The following information must appear on the title page:
185
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a. Study title. The study title should be as descriptive as possible It must clearly identify
the substance(s) tested and correspond to the name of the data requirement as it appears in the Guidelines.
b. Data requirement addressed. Include on the title page the Guideline number (s) of the
specific requirement (s) addressed by the study.
c. Author (s). Cite only individuals with primary intellectual responsibility for the content
of the study. Identify them plainly as authors, to distinguish them from the performing
laboratory, study sponsor, or other names that may also appear on the title page.
d. Study Date. The title page must include a single date for the study. If parts of the
study were performed at different times, use only the date of the latest element in the study.
e. Performing Laboratory Identification. If the study reports work done by one or more
laboratories, include on the title page the name and address of the performing laboratory or
laboratories, and the laboratory's internal project number (s) for the work. Clearly distinguish
the laboratory's project identifier from any other reference numbers provided by the study
sponsor or submitter.
f. Supplemental Submissions. If the study is a commentary on or supplement to another
previously submitted study, or if it responds to EPA questions raised with respect to an earlier
study, include on the title page elements a. through d. for the previously submitted study,
along with the EPA Master Record Identifier (MRID) or Accession number of the earlier
study if you know these numbers. (Supplements submitted in the same submittal package as
the primary study should be appended to and bound with the primary study. Do not include
supplements to more than one study under a single title page).
g. Facts of Publication. If the study is a reprint of a published document, identity on the
title page all relevant facts of publication, such as the journal title, volume, issue, inclusive
page numbers, and publication date.
D.2. Statements of Data Confidentiality Claims Under FIFRA §10(d)(l).
Each submitted study must be accompanied by one of the two alternative forms of the
statement of Data Confidentiality Claims specified in the proposed regulation in §158.33 (b)
and (c) (See Attachment 3). These statements apply only to claims of data confidentiality
based on FIFRA §10(d)(l)(A), (B), or (C). Use the appropriate alternative form of the
statement either to assert a claim of §10(d)(l) data confidentiality (§158.33(b)) or to waive
such a claim (§158.33(c)). In either case, the statement must be signed and dated, and must
include the typed name and title of the official who signs it. Do not make CBI claims with
respect to analytical methods associated with pet-itions for tolerances or emergency
exemptions (see NOTE Pg 13).
D.3. Confidential Attachment
If the claim is made that a study includes confidential business information as defined
by the criteria of FIFRA §10(D)(1)(A), (B), or (C) (as described in D.2. above) all such
information must be excised from the body of the study and confined to a separate
study-specific Confidential Attachment. Each passage of CBI so isolated must be identified by
a reference number cited within the body of the study at the point from which the passage was
excised (See Attachment 5).
The Confidential Attachment to a study must be identified by a cover sheet fully
identifying the parent study, and must be clearly marked "Confidential Attachment." An
appropriately annotated photocopy of the parent study title page may be used as this cover
sheet. Paginate the Confidential Attachment separately from the body of the study, beginning
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with page 1 of X on the title page. Each passage confined to the Confidential Attachment
must be associated with a specific cross reference to the page(s) in the main body of the study
on which it is cited, and with a reference to the applicable passage(s) of FIFRA §10(d)(l) on
which the confidentiality claim is based.
D.4. Supplemental Statement of Data Confidentiality Claims (See
Attachment 4)
If you wish to make a claim of confidentiality for any portion of a submitted study
other than described by FIFRA §10(d) (1)(A), (B), or (C), the following provisions apply:
- The specific information to which the claim applies must be clearly marked in the
body or the study as subject to a claim of confidentiality.
- A Supplemental Statement of Data Confidentiality Claims must be submitted,
identifying each passage claimed confidential and describing in detail the basis for the
claim. A list of the points to address in such a statement is included in Attachment 4
on Pg 14.
- The Supplemental Statement of Data Confidentiality Claims must be signed and dated
and must include the typed name and title of the official who signed it.
D.5. Good Laboratory Practice Compliance Statement
This statement is required if the study contains laboratory work subject to GLP
requirements specified in 40 CFR 160. Samples of these statements are shown in Attachment
6.
E. Reference to Previously Submitted Data
DO NOT RESUBMIT A STUDY THAT HAS PREVIOUSLY BEEN SUBMITTED
FOR ANOTHER PURPOSE unless EPA specifically requests it. A copy of the title page
plus the MRID number (if known) is sufficient to allow us to retrieve the study immediately
for review. This prevents duplicate entries in the Agency files, and saves you
the cost of sending more copies of the study. References to previously submitted studies
should not be included in the transmittal document, but should be incorporated into the
statemenTof the method of support for the application.
F. Physical Format Requirements
All elements in the data submittal package must be on uniform 8 1/2 by 11 inch white
paper, printed on one side only in black ink, with high contrast and good resolution. Bindings
for individual studies must be secure, but easily removable to permit disassembly for
microfilming. Check with EPA for special instructions before submitting data in any medium
other than paper, such as film or magnetic media.
Please be particularly attentive to the following points:
• Do not include frayed or torn pages.
• Do not include carbon copies, or copies in other than black ink.
• Make sure that photocopies are clear, complete, and fully readable.
• Do not include oversize computer printouts or fold-out pages.
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• Do not bind any documents with glue or binding tapes.
• Make sure that all pages of each study, including any attachments or
appendices, are present and in correct sequence.
Number of Copies Required - All submittal packages except those associated with a
Registration Standard or Special Review (See Part G below) must be provided In three
complete, identical copies. (The proposed regulations specified two copies; three are now
being required to expedite and reduce the cost of processing data into the OPP Pesticide
Document Management System and getting it into review.)
G. Special Requirements for Submitting Data to the Docket
Data submittal packages associated with a Registration Standard or Special Review
must be provided in four copies, from one of which all material claimed as CBI has been
excised. This fourth copy will become part of the public docket for the RS or SR case. If no
claims of confidentiality are made for the study, the fourth copy should be identical to the
other three. When portions of a study submitted in support or an RS or SR are claimed as
CBI, the first three copies will include the CBI material as provided in section D of this
notice. The following special preparation is required for the fourth copy.
• Remove the "Supplemental Statement of Data Confidentiality Claims".
• Remove the "Confidential Attachment".
• Excise from the body of the study any information you claim as confidential,
even if it does not fall within the scope of FIFRA §10(d)(l)(A), (B), or (C).
Do not close up or paraphrase text remaining after this excision.
Mark the fourth copy plainly on both its cover and its title page with the phi
"Public Docket Material - contains no information claimed as confidential".
ihrase
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V. For Further Information
For further information contact John Carley, Chief, Information Services Branch,
Program Management and Support Division, (703) 305-5240.
/S/
James W. Akerman
Acting Director,
Registration Division
Attachment 1. Sample Transmittal Document
Attachment 2. Sample Title Page for a Newly Submitted Study
Attachment 3. Statements of Data Confidentiality Claims
Attachment 4. Supplemental Statement of Data Confidentiality Claims
Attachment 5. Samples of Confidential Attachments
Attachment 6. Sample Good Laboratory Practice Statements
Attachment 7. Format Diagrams for Submittal Packages and Studies
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ATTACHMENT 1
ELEMENTS TO BE INCLUDED IN THE TRANSMITTAL DOCUMENT*
1. Name and address of submitter (or all joint submitters**)
+ Smith Chemical Corporation Jones Chemical Company
1234 West Smith Street -and- 5678 Wilson Blvd
Cincinnati, OH 98765 Covington, KY 56789
+ Smith Chemical Corp will act as sole agent for all submitters.
2. Regulatory action in support of which this package is submitted
Use the EPA identification number (e.g. 359-EUP-67) if you know it. Otherwise describe the
type of request (e.g. experimental use permit, data call-in - of xx-xx-xx date).
3. Transmittal date
4. List of submitted studies
Vol 1. Administrative materials - forms, previous corres-pondence with Project
Managers, and so forth.
Vol 2. Title of first study in the submittal (Guideline No.)
Vol n Title of nth study in the submittal (Guideline
No.)
* Applicants commonly provide this information in a tran-smittal letter. This
remains an acceptable practice so long as all four elements are included.
* Indicate which of the joint submitters is empowered to act on behalf of all joint
submitters in any matter concerning data compensation or subsequent use or
release of the data.
Company Official:
Name Signature
Company Name
Company Contact:
Name Phone
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ATTACHMENT 2
SAMPLE STUDY TITLE PAGE FOR A NEWLY SUBMITTED STUDY
Study Title
(Chemical name) - Magnitude of Residue on Corn
Data Requirement
Guideline 171-4
Author
John C. Davis
Study Completed On
Januarys, 1979
Performing Laboratory
ABC Agricultural Laboratories
940 West Bay Drive
Wilmington, CA 39897
Laboratory Project ID
ABC 47-79
Page 1 of X
(X is the total number of pages in the study)
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ATTACHMENT 3
STATEMENTS OF DATA CONFIDENTIALITY CLAIMS
1. No claim of confidentiality under FIFRA §10(d)(l)(A),(B), or (C).
STATEMENT OF NO DATA CONFIDENTIALITY CLAIMS
No claim of confidentiality is made for any information contained in this
study on the basis of its falling within the scope of FIFRA
6§10(d)(1)(A), (B), or (C).
Company
Company Agent: Typed Name Date:
Title Signature
2. Claim of confidentiality under FIFRA §10(d)(l)(A), (B), or (C).
Information claimed confidential on the basis of its falling within the
scope of FIFRA §10(d)(1)(A), (B), or (C) has been removed to a
confidential appendix, and is cited by cross-reference number in the body
of the study.
Company:
Company Agent: Typed Name Date:
Title Signature
STATEMENT OF DATA CONFIDENTIALITY CLAIMS
NOTE: Applicants for permanent or temporary tolerances should note that it is OPP policy
that no permanent tolerance, temporary tolerance, or request for an emergency exemption
incorporating an analytical method, can be approved unless the applicant waives all claims of
confidentiality for the analytical method. These analytical methods are published in the FDA
Pesticide Analytical Methods Manual, and therefore cannot be claimed as confidential. OPP
implements this policy by returning submitted analytical methods, for which confidentiality
claims have been made, to the submitter, to obtain the confidentiality waiver before they can
be processed.
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ATTACHMENT 4
SUPPLEMENTAL STATEMENT OF DATA CONFIDENTIALITY CLAIMS
For any portion of a submitted study that is not described by FIFRA §10(d)(l)(A), (B),
or (C), but for which you claim confidential treatment on another basis, the following
information must be included within a Supplemental Statement of Data Confidentiality Claims:
• Identify specifically by page and line number (s) each portion of the study for
which you claim confidentiality.
• Cite the reasons why the cited passage qualifies for confidential treatment.
• Indicate the length of time—until a specific date or event, or permanently—for
which the information should be treated as confidential.
• Identify the measures taken to guard against undesired disclosure of this
information.
• Describe the extent to which the information has been disclosed, and what
precautions have been taken in connection with those disclosures.
• Enclose copies of any pertinent determinations of confidentiality made by EPA,
other Federal agencies, of courts concerning this information.
• If you assert that disclosure of this information would be likely to result in
substantial harmful effects to you, describe those harmful effects and explain
why they should be viewed as substantial.
• If you assert that the information in voluntarily submitted, indicate whether you
believe disclosure of this information might tend to lessen the availability to
EPA of similar information in the future, and if so, how.
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ATTACHMENT 5
EXAMPLES OF SEVERAL CONFIDENTIAL ATTACHMENTS
Example 1. (Confidential word or phrase that has been deleted from the study)
CROSS REFERENCE NUMBER 1 This cross reference number is used in the study in place of the
following paragraph (s) at the indicated volume and page
references.
DELETED WORDS OR PHRASE: Ethylene Glycol
PAGE LINES REASON FOR THE DELETION FIFRA
REFERENCE
6 14 Identity of Inert Ingredient §10(d)(C)
28 25
100 19
Example 2. (Confidential paragraph(s) that have been deleted from the study)
CROSS REFERENCE NUMBER 5 This cross reference number is used in the study in place of the
following paragraph (s) at the indicated volume and page
references.
DELETED PARAGRAPH(S) :
( )
( Reproduce the deleted paragraph (s) here )
PAGE LINES REASON FOR THE DELETION FIFRA REFERENCE
20. 2-17 Description of the quality control process § 1 0 (d) ( 1) (C)
Example 3. (Confidential pages that have been deleted from the study)
CROSS REFERENCE NUMBER 7 This cross reference number is used in the study in place of the
following paragraph (s) at the indicated volume and page
references.
DELETED PAGES(S): are attached immediately behind this page
PAGES REASON FOR THE DELETION FIFRA REFERENCE
35-41. Description of product manufacturing process § 10 (d) (1) (A)
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ATTACHMENT 6.
SAMPLE GOOD LABORATORY PRACTICE STATEMENTS
Example 1.
This study meets the requirements for 40 CFR Part 160
Submitter
Sponsor
Example 2.
This study does not meet the requirements of 40 CFR Part 160, and
differs in the following ways:
1.
2.
3.
Submitter
Sponsor
Study Director_
Example 3.
The submitter of this study was neither the sponsor of this study nor
conducted it, and does not know whether it has been conducted in
accordance with 40 CFR Part 160.
Submitter
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ATTACHMENT 7.
FORMAT OF THE SUBMITTAL PACKAGE
Transmittal Document
Related Administrative Materials
(e.g. Method of Support Statement, etc.)
Other materials about the submittal
(e.g., summaries of groups of studies
to aid in their review).
Studies submitted as unique
to the format below.
FORMAT OF SUBMITTED STUDIES
• Study title page.
• Statement of Confidentiality Claims.
. GLP and flagging* statements - as appropriate.
Body of the study, with English
language translation if required.
Appendices to the study.
Title Page of the Confidential
Attachment.
Confidential Attachment.
:—":' _. *""} . Supplemental Statement
i..-(•-"'' j of Confidentiality Claims
• ' * When flagging requirements
are finalised.
Documents which must be submitted as
appropriate to meet established requirements.
Documents submitted at submitter's option.
LEGEND
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200
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PR Notice 91-2
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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, B.C. 20460
OFFICE OF
PREVENTION, PESTICIDES
AND TOXIC SUBSTANCES
PR NOTICE 91 -2
NOTICE TO MANUFACTURERS, PRODUCERS, FORMULATORS,
AND REGISTRANTS OF PESTICIDES
ATTENTION: Persons Responsible for Federal Registration of Pesticide Products.
SUBJECT: Accuracy of Stated Percentages for Ingredients
Statement
I. PURPOSE:
The purpose of this notice is to clarify the Office of Pesticide Program's policy with
respect to the statement of percentages in a pesticide's label's ingredient statement.
Specifically, the amount (percent by weight) of ingredient(s) specified in the ingredient
statement on the label must be stated as the nominal concentration of such ingredient(s), as that
term is defined in 40 CFR 158.153(i). Accordingly, the Agency has established the nominal
concentration as the only acceptable label claim for the amount of active ingredient in the
product.
II. BACKGROUND
For some time the Agency has accepted two different methods of identifying on the
label what percentage is claimed for the ingredient (s) contained in a pesticide. Some applicants
claimed a percentage which represented a level between the upper and the lower certified
limits. This was referred to as the nominal concentration. Other applicants claimed the lower
limit as the percentage of the ingredient(s) that would be expected to be present in their
product at the end or the product's shelf-life. Unfortunately, this led to a great deal of
confusion among the regulated industry, the regulators, and the consumers as to exactly how
much of a given ingredient was in a given product. The Agency has established the nominal
concentration as the only acceptable label claim for the amount of active ingredient in the
product.
Current regulations require that the percentage listed in the active ingredient statement
be as precise as possible reflecting good manufacturing practices 40 CFR 156.10(g)(5). The
certified limits required for each active ingredient are intended to encompass any such "good
manufacturing practice" variations 40 CFR 158.175(c)(3).
The upper and lower certified limits, which must be proposed in connection with a
product's registration, represent the amounts of an ingredient that may legally be present 40
CFR 158.1/5. The lower certified limit is used as the enforceable lower limit for the product
composition according to FIFRA section 12(a)(l)(C), while the nominal concentration
appearing on the label would be the routinely achieved concentration used for calculation of
dosages and dilutions.
The nominal concentration would in fact state the greatest degree of accuracy that is
warranted with respect to actual product composition because the nominal concentration would
be the amount of active ingredient typically found in the product.
It is important for registrants to note that certified limits for active ingredients are not
considered to be trade secret information under FIFRA section 10 (b). In this respect the
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certified limits will be routinely provided by EPA to States for enforcement purposes, since
the nominal concentration appearing on the label may not represent the enforceable
composition for purposes or section 12(a)(l)(C).
III. REQUIREMENTS
As described below under Unit V. " COMPLIANCE SCHEDULE," all currently
registered products as well as all applications for new registration must comply with this
Notice by specifying the nominal concentration expressed as a percentage by weight as the
label claim in the ingredient(s) statement and equivalence statements if applicable (e.g.,
elemental arsenic, metallic zinc, salt of an acid). In addition, the requirement for performing
sample analyses of five or more representative samples must be fulfilled. Copies of the raw
analytical data must be submitted with the nominal ingredient label claim. Further information
about the analysis requirement may be found in the 40 CFR 158.170. All products are
required to provide certified limits for each active, inert ingredient, impurities of toxicological
significance (i.e., upper limit(s) only) and on a case by case basis as specified by EPA. These
limits are to be set based on representative sampling and chemical analysis (i.e., quality
control) of the product.
The format of the ingredient statement must conform to 40 CFR 156-Labeling
Requirements For Pesticides and Devices.
After July 1, 1997, all pesticide ingredient Statements must be changed to
nominal concentration.
IV. PRODUCTS THAT REQUIRE EFFICACY DATA
All pesticides are required to be efficacious. Therefore, the certified lower limits may
not be lower then the minimum level to achieve efficacy. This is extremely important for
products which are intended to control pests which threaten the public health, e.g., certain
antimicrobial and rodenticide products. Refer to 40 CFR 153.640.
In those cases where efficacy limits have been established, the Agency will not accept
certified lower limits which are below that level for the shelf life of the product.
V. COMPLIANCE SCHEDULE
As described earlier, the purpose of this Notice is to make the registration process
more uniform and more manageable for both the agency and the regulated community. It is
the Agency's intention to implement the requirements of this notice as smoothly as possible so
as not to disrupt or delay the Agency's high priority programs, i.e., reregistration, new
chemical, or fast track (FIFRA section 3(c)(3)(B). Therefore, applicants/registrants are
expected to comply with the requirements of this Notice as follows:
(1) Beginning July 1, 1991, all new product registrations submitted to the Agency
are to comply with the requirements of this Notice.
(2) Registrants having products subject to reregistration under FIFRA section 4 (a)
are to comply with the requirements of this Notice when specific products are
called in by the Agency under Phase V of the Reregistration Program.
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(3) All other products/applications that are not subject to (1) and (2) above will
have until July 1, 1557, to comply with this Notice. Such applications should
note "Conversion to Nominal Concentrations on the application form. These
types Or amendments will not be handled as "Fast Track" applications but will
be handled as routine requests.
VI. FOR FURTHER INFORMATION
Contact Tyrone Aiken for information or questions concerning this notice on (703) 308-7031.
/s/
Anne E. Lindsay, Director
Registration Division (H-7505C)
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APPENDIX F. Combined Generic and Product Specific
Data Call-In
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I UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20460
OFFICE OF
PREVENTION. PESTICIDES
AND TOXIC SUBSTANCES
GENERIC AND PRODUCT SPECIFIC
DATA CALL-IN NOTICE
CERTIFIED MAIL
Dear Sir or Madam:
This Notice requires you and other registrants of pesticide products containing the
active ingredient identified in Attachment A of this Notice, the Data Call-In Chemical Status
Sheet, to submit certain data as noted herein to the U.S. Environmental Protection Agency
(EPA, the Agency). These data are necessary to maintain the continued registration of your
product(s) containing this active ingredient. Within 90 days after you receive this Notice you
must respond as set forth in Section III below. Your response must state:
1. How you will comply with the requirements set forth in this Notice and its
Attachments 1 through 7; or
2. Why you believe you are exempt from the requirements listed in this Notice and
in Attachment 3 (for both generic and product specific data), the Requirements
Status and Registrant's Response Form, (see section III-B); or
3. Why you believe EPA should not require your submission of data in the manner
specified by this Notice (see section III-D).
If you do not respond to this Notice, or if you do not satisfy EPA that you will comply
with its requirements or should be exempt or excused from doing so, then the registration of
your product(s) subject to this Notice will be subject to suspension. We have provided a list of
all of your products subject to this Notice in Attachment 2. All products are listed on both the
generic and product specific Data Call-in Response Forms. Also included is a list of all
registrants who were sent this Notice (Attachment 6).
The authority for this Notice is section 3(c)(2)(B) of the Federal Insecticide, Fungicide
and Rodenticide Act as amended (FIFRA), 7 U.S.C. section 136a(c)(2)(B). Collection of this
information is authorized under the Paperwork Reduction Act by OMB Approval No.
2070-0107 and 2070-0057 (expiration date 3-31-96).
This Notice is divided into six sections and seven Attachments. The Notice itself
contains information and instructions applicable to all Data Call-In Notices. The Attachments
contain specific chemical information and instructions. The six sections of the Notice are:
Section I - Why You are Receiving this Notice
Section II - Data Required by this Notice
Section III - Compliance with Requirements of this Notice
Section IV - Consequences of Failure to Comply with this Notice
Section V - Registrants' Obligation to Report Possible Unreasonable Adverse Effects
Section VI - Inquiries and Responses to this Notice
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The Attachments to this Notice are:
1 - Data Call-in Chemical Status Sheet
2 - Generic Data Caii-ln and Product Specific Data Call-in Response Forms with
Instructions
3 - Generic Data Call-In and Product Specific Data Call-In Requirements Status
and Registrant's Response Forms with Instructions
4 - EFA Batching or End-Use Products for Meeting Acute Toxicology Data
Requirements tor Keregistration
5 - FFA Acceptance Criteria
6 - List or Registrants Receiving This Notice
7 - Cost Share and Data Compensation Forms
SECTION I. WHY YOU ARE RECEIVING THIS NOTICE
The Agency has reviewed existing data for this active ingredient (s) and reevaluated the
data needed to support continued registration of the subject active ingredient(s). This
reevaluation identified additional data necessary to assess the health and safety of the continued
use of products containing this active ingredient(s). You have been sent this Notice because
you have product (s) containing the subject active ingredients.
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SECTION II. DATA REQUIRED BY THIS NOTICE
II-A. DATA REQUIRED
The data required by this Notice are specified in the Requirements Status and
Registrant's Response Forms: Attachment 3 (for both generic and product specific data
requirements). Depending on the results of the studies required in this Notice, additional
studies/testing may be required.
II-B. SCHEDULE FOR SUBMISSION OF DATA
You are required to submit the data or otherwise satisfy the data requirements specified
in the Requirements Status and Registrant's Response Forms (Attachment 3) within the
timeframes provided.
II-C. TESTING PROTOCOL
All studies required under this Notice must be conducted in accordance with test
standards outlined in the Pesticide Assessment Guidelines for those studies for which
guidelines have been established.
These EPA Guidelines are available from the National Technical Information Service
(NTIS), Attn: Order Desk, 5285 Port Royal Road, Springfield, Va 22161 (Telephone number:
703-487-4650).
Protocols approved by the Organization for Economic Cooperation and Development
(OECD) are also acceptable if the OECD recommended test standards conform to those
specified in the Pesticide Data Requirements regulation (40 CFR § 158.70). When using the
OECD protocols, they should be modified as appropriate so that the data generated by the
study will satisfy the requirements of 40 CFR § 158. Normally, the Agency will not extend
deadlines for complying with data requirements when the studies were not conducted in
accordance with acceptable standards. The OECD protocols are available from OECD, 2001 L
Street, N.W., Washington, D.C. 20036 (Telephone number 202-785-6323; Fax telephone
number 202-785-0350).
All new studies and proposed protocols submitted in response to this Data Call-In
Notice must be in accordance with Good Laboratory Practices [40 CFR Part 160].
II-D. REGISTRANTS RECEIVING PREVIOUS SECTION 3(c)(2)(B) NOTICES ISSUED
1JY THE AGENCY
Unless otherwise noted herein, this Data Call-in does not in any way supersede or
change the requirements of any previous Data Call-ln(s), or any other agreements entered into
with the Agency pertaining to such prior Notice. Registrants must comply with the
requirements of all Notices to avoid issuance of a Notice of Intent to Suspend their affected
products.
SECTION III. COMPLIANCE WITH REQUIREMENTS OF THIS NOTICE
You must use the correct forms and instructions when completing your response to this
Notice. The type of Data Call-In you must comply with (Generic or Product Specific) is
specified in item number 3 on the four Data Call-in forms (Attachments 2 and 3).
III-A. SCHEDULE FOR RESPONDING TO THE AGENCY
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The appropriate responses initially required by this Notice for generic and product
specific data must be submitted to the Agency within 90 days after your receipt of this Notice.
Failure to adequately respond to this Notice within 90 days of your receipt will be a basis for
issuing a Notice of Intent to Suspend (NOIS) affecting your products. This and other bases for
issuance of NOIS due to failure to comply with this Notice are presented in Section IV-A and
IV-B.
III-B. OPTIONS FOR RESPONDING TO THE AGENCY
1. Generic Data Requirements
The options for responding to this Notice for generic data requirements are: (a)
voluntary cancellation, (b) delete use(s), (c) claim generic data exemption, (d) agree to satisfy
the generic data requirements imposed by this Notice or (e) request a data waiver (s).
A discussion of how to respond if you choose the Voluntary Cancellation option, the
Delete Use(s) option or the Generic Data Exemption option is presented below. A discussion
of the various options available for satisfying the generic data requirements of this Notice is
contained in Section III-C. A discussion of options relating to requests for data waivers is
contained in Section III-D.
Two forms apply to generic data requirements, one or both of which must be used in
responding to the Agency, depending upon your response. These two forms are the
Data-Call-in Response Form, and the Requirements Status and Registrant's Response Form,
(contained in Attachments 2 and 3, respectively).
The Data Call-In Response Forms must be submitted as part of every response to this
Notice. The Requirements Status and Registrant's Response Forms also must be submitted if
you do not quality tor a Generic Data Exemption or are not requesting voluntary cancellation
of your registration^). Please note that the company's authorized representative is required to
sign the first page of both Data Call-In Response Forms and the Requirements Status and
Registrant's Response Forms (it this form is required) and initial any subsequent pages. The
forms contain separate detailed instructions on the response options. Do not alter the printed
material. If you have questions or need assistance in preparing your response, call or write the
contact person (s) identified in Attachment 1.
a. Voluntary Cancellation -
You may avoid the requirements of this Notice by requesting voluntary cancellation of
your product (s) containing the active ingredient that is the subject of this Notice. If you wish
to voluntarily cancel your product, you must submit completed Generic and Product Specific
Data Call-In Response Forms (Attachment 2), indicating your election of this option.
Voluntary cancellation is item number 5 on both Data Call-In Response Form(s). If you
choose this option, these are the only forms that you are required to complete.
If you chose to voluntarily cancel your product, further sale and distribution of your
product after the effective date of cancellation must be in accordance with the Existing Stocks
provisions of this Notice, which are contained in Section IV-C.
b. Use Deletion -
You may avoid the requirements of this Notice by eliminating the uses of your product
to which the requirements apply. If you wish to amend your registration to delete uses, you
must submit the Requirements Status and Registrant's Response Form (Attachment 3), a
completed application tor amendment, a copy of your proposed amended labeling, and all
other information required for processing the application. Use deletion is option number 7
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under item 9 in the instructions for the Requirements Status and Registrant's Response Forms.
You must also complete a Data Call-In Response Form by signing the certification, item
number 8. Application forms tor amending registrations may be obtained from the
Registration Support Branch, Registration Division, Office of Pesticide Programs, EPA, by
calling (703) ~~-~
If you choose to delete the use(s) subject to this Notice or uses subject to specific data
requirements, further sale, distribution, or use of your product after one year from the due
date of your 90 day response, is allowed only if the product bears an amended label.
c. Generic Data Exemption -
Under section 3(c)(2)(D) of FIFRA, an applicant for registration of a product is
exempt from the requirement to submit or cite generic data concerning an active ingredient if
the active ingredient in the product is derived exclusively from purchased, registered pesticide
products containing the active ingredient. EPA has concluded, as an exercise of its discretion,
that it normally will not suspend the registration of a product which would qualify and
continue to qualify for the generic data exemption in section 3(c)(2)(D) of FIFRA. To qualify,
all of the following requirements must be met:
(i). The active ingredient in your registered product must be present solely because of
incorporation of another registered product which contains the subject active ingredient
and is purchased from a source not connected with you;
(ii). Every registrant who is the ultimate source of the active ingredient in your
product subject to this DCI must be in compliance with the requirements of this Notice
and must remain in compliance; and
(iii). You must have provided to EPA an accurate and current " Confidential Statement
of Formula" for each of your products to which this Notice applies.
To apply for the Generic Data Exemption you must submit a completed Data Call-in
Response Form, Attachment 2 and all supporting documentation. The Generic Data Exemption
is item number 6a on the Data Call-in Response Form. If you claim a generic data exemption
you are not required to complete the Requirements Status and Registrant's Response Form.
Generic Data Exemption cannot be selected as an option for responding to product specific
data requirements.
If you are granted a Generic Data Exemption, you rely on the efforts of other persons
to provide the Agency with the required data. If the registrant^) who have committed to
generate and submit the required data fail to take appropriate steps to meet requirements or are
no longer in compliance with this Data Call-In Notice, the Agency will consider that both they
and you are not compliance and will normally initiate proceedings to suspend the registrations
of both your and their product(s), unless you commit to submit and do submit the required
data within the specified time. In such cases the Agency generally will not grant a time
extension for submitting the data.
d. Satisfying the Generic Data Requirements of this Notice
There are various options available to satisfy the generic data requirements of this
Notice. These options are discussed in Section III-C.l. of this Notice and comprise options 1
through 6 of item 9 in the instructions for the Requirements Status and Registrant's Response
Form and item 6b on the Data Call-In Response Form. If you choose item 6b (agree to satisfy
the generic data requirements), you must submit the Data Call-In Response Form and the
Requirements Status and Registrant's Response Form as well as any other information/data
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pertaining to the option chosen to address the data requirement. Your response must be on the
Forms marked "GENERIC" in item number 3.
e. Request for Generic Data Waivers.
Waivers for generic data are discussed in Section III-D.l. of this Notice and are
covered by options 8 and 9 of item 9 in the instructions for the Requirements Status and
Registrant's Response Form. If you choose one of these options, you must submit both forms
as well as any other information/data pertaining to the option chosen to address the data
requirement.
2. Product Specific Data Requirements
The options for responding to this Notice for product specific data are: (a) voluntary
cancellation, (b) agree to satisfy the product specific data requirements imposed by this Notice
or (c) request a data waiver (s).
A discussion of how to respond if you choose the Voluntary Cancellation option is
presented below. A discussion of the various options available for satisfying the product
specific data requirements of this Notice is contained in Section III-C.2. A discussion of
options relating to requests for data waivers is contained in Section III-D.2.
Two forms apply to the product specific data requirements one or both of which must
be used in responding to the Agency, depending upon your response. These forms are the
Data-Call-in Response Form, and the Requirements Status and Registrant's Response Form,
for product specific data (contained in Attachments 2 and 3, respectively). 1 he Data CallTn
Response Form must be submitted as part of every response to this Notice. In addition, one
copy of the Requirements Status and Registrant's Response Form also must be submitted for
each product listed on the Data Caii-ln Response Form uniess the voluntary cancellation option
is selected. Please note that the company's authorized representative is required to sign the
first page of the Data Call-In Response Form and Requirements Status and Registrant s
Response Form (if this form is required) and initial any subsequent pages. The forms contain
separate detailed instructions on the response options. Do not alter the printed material. If you
have questions or need assistance in preparing your response, call or write the contact
person(s) identified in Attachment 1.
a. Voluntary Cancellation
You may avoid the requirements of this Notice by requesting voluntary cancellation of
your product (s) containing the active ingredient that is the subject of this Notice. If you wish
to voluntarily cancel your product, you must submit a completed Data Call-In Response Form,
indicating your election of this option. Voluntary cancellation is item number b on both the
Generic and Product Specific Data Call-in Response Forms. If you choose this
option, you must complete both Data Call-In response forms. These are the only forms that
you are required to complete.
If you choose to voluntarily cancel your product, further sale and distribution of your
product after the effective date of cancellation must be in accordance with the Existing Stocks
provisions of this Notice which are contained in Section IV-C.
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b. Satisfying the Product Specific Data Requirements of this Notice.
There are various options available to satisfy the product specific data requirements of
this Notice. These options are discussed in Section III-C.2. of this Notice and comprise
options 1 through 6 of item 9 in the instructions for the product specific Requirements Status
and Registrant's Response Form and item numbers 7a and 7b (agree to satisfy the product
specific data requirements tor an MUP or EUP as applicable) on the product specific Data
Call-in Response Form. Note that the options available for addressing product specific data
requirements differ slightly from those options for fulfilling generic data requirements.
Deletion of a use(s) and the low volume/minor use option are not valid options for fulfilling
product specific data requirements. It is important to ensure that you are using the correct
forms and instructions when completing your response to the Reregistration Eligibility
Decision document.
c. Request for Product Specific Data Waivers.
Waivers for product specific data are discussed in Section III-D.2. of this Notice and
are covered by option 7 of item 9 in the instructions for the Requirements Status and
Registrant's Response Form. If you choose this option, you must submit the Data Call-In
Response Form and the Requirements Status and Registrant's Response Form as well as any
other information/data pertaining to the option chosen to address the data requirement. Your
response must be on the forms marked "PRODUCT SPECIFIC" in item number 3.
III-C SATISFYING THE DATA REQUIREMENTS OF THIS NOTICE
1. Generic Data
If you acknowledge on the Generic Data Call-In Response Form that you agree to
satisfy the generic data requirements (i.e. you select item number 6b), then you must select
one of the six options on the Generic Requirements Status and Registrant's Response Form
related to data production for each data requirement. Your option selection should be entered
under item number 9, "Registrant Response." The six options related to data production are
the first six options discussed under item 9 in the instructions for completing the Requirements
Status and Registrant's Response Form. These six options are listed
immediately below with information in parentheses to guide you to additional instructions
provided in this Section. The options are:
(1) I will generate and submit data within the specified timeframe (Developing
Data)
(2) I have entered into an agreement with one or more registrants to develop data
jointly (Cost Sharing)
I have made offers to cost-share (Offers to Cost Share)
I am submitting an existing study that has not been submitted previously to the
Agency by anyone (Submitting an Existing Study)
(5) I am submitting or citing data to upgrade a study classified by EPA as partially
acceptable and upgradeable (Upgrading a Study)
(6) I am citing an existing study that EPA has classified as acceptable or an existing
study that has been submitted but not reviewed by the Agency (Citing an
-i-i.-i. Oj_1\ OJVO
Existing Study)
Option 1. Developing Data
If you choose to develop the required data it must be in conformance with Agency
deadlines and with other Agency requirements as referenced herein and in the attachments. All
data generated and submitted must comply with the Good Laboratory Practice (GLP) rule (40
CFR Part 160), be conducted according to the Pesticide Assessment Guidelines (PAG) and be
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in conformance with the requirements of PR Notice 86-5. In addition, certain studies require
Agency approval of test protocols in advance of study initiation. Those studies for which a
protocol must be submitted have been identified in the Requirements Status and Registrant's
Response Form and/or footnotes to the form. If you wish to use a protocol which differs from
the options discussed in Section II-C of this Notice, you must submit a detailed description of
the proposed protocol and your reason for wishing to use it. The Agency may choose to reject
a protocol not specified in Section II-C. If the Agency rejects your protocol you will be
notified in writing, however, you should be aware that rejection of a proposed protocol will
not be a basis for extending the deadline for submission of data.
A progress report must be submitted for each study within 90 days from the date you
are required to commit to generate or undertake some other means to address that study
requirement, such as making an offer to cost share or agreeing to share in the cost of
developing that study. This 90-day progress report must include the date the study was or will
be initiated and, for studies to be started within 12 months of commitment, the name and
address of the laboratory(ies) or individuals who are or will be conducting the study.
In addition, if the time frame for submission of a final report is more than 1 year,
interim reports must be submitted at 12 month intervals from the date you are required to
commit to generate or otherwise address the requirement for the study. In addition to the other
information specified in the preceding paragraph, at a minimum, a brief description of current
activity on and the status of the study must be included as well as a full
description of any problems encountered since the last progress report.
The time frames in the Requirements Status and Registrant's Response Form are the
time frames that the Agency is allowing for the submission of completed study reports or
protocols. The noted deadlines run from the date of the receipt of this Notice by the registrant.
If the data are not submitted by the deadline, each registrant is subject to receipt of a Notice of
Intent to Suspend the affected registration(s).
If you cannot submit the data/reports to the Agency in the time required by this Notice
and intend to seek additional time to meet the requirements(s), you must submit a request to
the Agency which includes: (1) a detailed description of the expected difficulty and (2) a
proposed schedule including alternative dates for meeting such requirements on a step-by-step
basis. You must explain any technical or laboratory difficulties and provide documentation
from the laboratory performing the testing. While EPA is considering your request, the
original deadline remains. The Agency will respond to your request in writing. If EPA does
not grant your request, the original deadline remains. Normally, extensions can be requested
only in cases of extraordinary testing problems beyond the expectation or control of the
registrant. Extensions will not be given in submitting the 90-day responses. Extensions will
not be considered if the request for extension is not made in a timely fashion; in no event shall
an extension request be considered if it is submitted at or after the lapse of the subject
deadline.
Option 2. Agreement to Share in Cost to Develop Data
If you choose to enter into an agreement to share in the cost of producing the required
data but will not be submitting the data yourself, you must provide the name of the registrant
who will be submitting the data. You must also provide EPA with documentary evidence that
an agreement has been formed. Such evidence may be your letter offering to join in an
agreement and the other registrant's acceptance of your offer, or a written statement by the
parties that an agreement exists. The agreement to produce the data need not specify all of the
terms of the final arrangement between the parties or the mechanism to resolve the terms.
Section 3(c)(2)(B) provides that if the parties cannot resolve the terms of the agreement they
may resolve their differences through binding arbitration.
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Option 3. Offer to Share in the Cost of Data Development
If you have made an offer to pay in an attempt to enter into an agreement or amend an
existing agreement to meet the requirements of this Notice and have been unsuccessful, you
may request EPA (by selecting this option) to exercise its discretion not to suspend your
registration(s), although you do not comply with the data submission requirements of this
Notice. EPA has determined that as a general policy, absent other relevant considerations, it
will not suspend the registration of a product of a registrant who has in good faith sought and
continues to seek to enter into a joint data development/cost sharing program, but the other
registrant^) developing the data has refused to accept the offer. To qualify for this option, you
must submit documentation to the Agency proving that you have made an offer to another
registrant (who has an obligation to submit data) to share in the burden of developing that
data. You must also submit to the Agency a completed EPA Form 8570-32, Certification of
Offer to Cost Share in the Development of Data, Attachment 7. In addition, you must
demonstrate that the other registrant to whom the offer was made has not accepted your offer
to enter into a cost-sharing agreement by including a copy of your offer and proof of the other
registrant's receipt of that offer (such as a certified mail receipt). Your offer must, in addition
to anything else, offer to share in the burden of producing the data upon terms to be agreed to
or, failing agreement, to be bound by binding arbitration as provided by FIFRA section
3(c)(2)(Bj(iii) and must not qualify this offer. The other registrant must also inform EPA of its
election of an option to develop and submit the data required by this Notice by submitting a
Data Call-In Response Form and a Requirements Status and Registrant's Response Form
committing to develop and submit the data required by this Notice.
In order for you to avoid suspension under this option, you may not withdraw your
offer to share in the burden of developing the data. In addition, the other registrant must fulfill
its commitment to develop and submit the data as required by this Notice. If the other
registrant fails to develop the data or for some other reason is subject to suspension, your
registration as well as that of the other registrant normally will be subject to initiation of
suspension proceedings, unless you commit to submit, and do submit, the required data in the
specified time frame. In such cases, the Agency generally will not grant a time extension for
submitting the data.
Option 4. Submitting an Existing Study
If you choose to submit an existing study in response to this Notice, you must
determine that the study satisfies the requirements imposed by this Notice. You may only
submit a study that has not been previously submitted to the Agency or previously cited by
anyone. Existing studies are studies which predate issuance of this Notice. Do not use this
option if you are submitting data to upgrade a study. (See Option 5).
You should be aware that if the Agency determines that the study is not acceptable, the
Agency will require you to comply with this Notice, normally without an extension of the
required date of submission. The Agency may determine at any time that a study is not valid
and needs to be repeated.
To meet the requirements of the DCI Notice for submitting an existing study, all of the
following three criteria must be clearly Met:
a. You must certify at the time that the existing study is submitted that the raw
data and specimens from the study are available for audit and review and you
must identify where they are available. This must be done in accordance with
the requirements of the Good Laboratory Practice (GLP) regulation, 40 CFR
Part 160. As stated in 40 CFR 160.3 'Raw data' means any laboratory
worksheets, records, memoranda, notes, or exact copies thereof, that are the
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result of original observations and activities of a study and are necessary for the
reconstruction and evaluation of the report of that study. In the event that exact
transcripts of raw data have been prepared (e.g., tapes which have been
transcribed verbatim, dated, and verified accurate by signature), the exact copy
or exact transcript may be substituted for the original source as raw data. 'Raw
data' may include photographs, microfilm or microfiche copies, computer
printouts, magnetic media, including dictated observations, and recorded data
from automated instruments." The term "specimens", according to 40 CFR
160.3, means "any material derived from a test system for examination or
analysis."
b. Health and safety studies completed after May 1984 also must also contain all
GLP-required quality assurance and quality control information, pursuant to the
requirements or 40 CFR Part 160. Registrants also must certify at the time of
submitting the existing study that such GLP information is available for post
May 1984 studies by including an appropriate statement on or attached to the
study signed by an authorized official or representative of the registrant.
c. You must certify that each study fulfills the acceptance criteria for the Guideline
relevant to the study provided in the FIFRA Accelerated Reregistration Phase 3
Technical Guidance and that the study has been conducted according to the
Pesticide Assessment Guidelines (PAG) or meets the purpose of the PAG (both
available from NTIS). A study not conducted according to the PAG may be
submitted to the Agency for consideration if the registrant believes that the
study clearly meets the purpose of the PAG. The registrant is referred to 40
CFR 158.70 which states the Agency's policy regarding acceptable protocols. If
you wish to submit the study, you must, in addition to certifying that the
purposes of the PAG are met by the study, clearly articulate the rationale why
you believe the study meets the purpose of the PAG, including copies of any
supporting information or data. It has been the Agency's experience that studies
completed prior to January 1970 rarely satisfied the purpose of the PAG and
that necessary raw data usually are not available for such studies.
If you submit an existing study, you must certify that the study meets all requirements
of the criteria outlined above.
If EPA has previously reviewed a protocol for a study you are submitting, you must
identify any action taken by the Agency on the protocol and must indicate, as part of your
certification, the manner in which all Agency comments, concerns, or issues were addressed
in the final protocol and study.
If you know of a study pertaining to any requirement in this Notice which does not
meet the criteria outlined above but does contain factual information regarding unreasonable
adverse effects, you must notify the Agency of such a study. If such study is in the Agency's
files, you need only cite it along with the notification. If not in the Agency's files, you must
submit a summary and copies as required by PR Notice 86-5.
Option 5. Upgrading a Study
If a study has been classified as partially acceptable and upgradeable, you may submit
data to upgrade that study. The Agency will review the data submitted and determine if the
requirement is satisfied. If the Agency decides the requirement is not satisfied, you may still
be required to submit new data normally without any time extension. Deficient, but
upgradeable studies will normally be classified as supplemental. However, it is important to
note that not all studies classified! as supplemental are upgradeable. If you have questions
regarding the classification of a study or whether a study may be upgraded, call or write the
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contact person listed in Attachment 1. If you submit data to upgrade an existing study you
must satisfy or supply information to correct all deficiencies in the study identified by EPA.
You must provide a clearly articulated rationale" of how the deficiencies have been remedied or
corrected and why the study should be rated as acceptable to EPA. Your submission must also
specify the MRID number (s) of the study which you are attempting to upgrade and must be in
conformance with PR Notice 86-5.
Do not submit additional data for the purpose of upgrading a study classified as
unacceptable and determined by the Agency as not capable of being upgraded.
This option also should be used to cite data that has been previously submitted to
upgrade a study, but has not yet been reviewed by the Agency. You must provide the MRID
number of the data submission as well as the MRID nurriber of the study being upgraded.
The criteria for submitting an existing study, as specified in Option 4 above, apply to
all data submissions intended to upgrade studies. Additionally, your submission of data
intended to upgrade studies must be accompanied by a certification that you comply with each
of those criteria, as well as a certification regarding protocol compliance with Agency
requirements.
Option 6. Citing Existing Studies
If you choose to cite a study that has been previously submitted to EPA, that study
must have been previously classified by EPA as acceptable, or it must be a study which has
not yet been reviewed by the Agency. Acceptable toxicology studies generally will have been
classified as "core-guideline" or "core-minimum." For ecological effects studies, the
classification generally would be a rating of "core." For all other disciplines the classification
would be "acceptable." With respect to any studies for which you wish to select this option,
you must provide the MRID number of the study you are citing and, if the study has been
reviewed by the Agency, you must provide the Agency's classification of the study.
If you are citing a study of which you are not the original data submitter, you must
submit a completed copy of EPA Form 8570-31, Certification with Respect to Data
Compensation Requirements.
2. Product Specific Data
If you acknowledge on the product specific Data Call-in Response Form that you agree
to satisfy the product specific data requirements (i.e. you select option (a or Yb), then you
must select one of the six options on the Requirements Status and Registrant's Response Form
related to data production for each data requirement. Your option selection should be entered
under item number 9, "Registrant Response." The six options related to data production are
the first six options discussed under item 9 in the instructions for completing the Requirements
Status and Registrant's Response Form. These six options are listed immediately below with
information in parentheses to guide registrants to additional instructions provided in this
Section. The options are:
(1) I will generate and submit data within the specified time-frame (Developing
Data)
(2) I have entered into an agreement with one or more registrants to develop data
jointly (Cost Sharing)
I have made offers to cost-share (Offers to Cost Share)
I am submitting an existing study that has not been submitted previously to the
Agency by anyone (Submitting an Existing Study)
(5) I am submitting or citing data to upgrade a study classified by EPA as partially
acceptable and upgradeable (Upgrading a Study)
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(6) I am citing an existing study that EPA has classified as acceptable or an existing
study that has been
submitted but not reviewed by the Agency (Citing an Existing Study)
Option 1. Developing Data — The requirements for developing product specific data are the
same as those described for generic data (see Section III.C.I, Option 1) except that normally
no protocols or progress reports are required.
Option 2. Agree to Share in Cost to Develop Data — If you enter into an agreement to cost
share, the same requirements apply to product specific data as to generic data (see Section
III.C.I, Option 2). However, registrants may only choose this option for acute toxicity data
and certain efficacy data and only if EPA has indicated in the attached data tables that your
product and at least one other product are similar for purposes of depending on
the same data. If this is the case, data may be generated for just one of the products in the
group. The registration number of the product for which data will be submitted must be noted
in the agreement to cost share by the registrant selecting this option.
Option 3. Offer to Share in the Cost of Data Development —The same requirements for
generic data (Section lll.C.l., Option 3) apply to this option. This option only applies to acute
toxicity and certain efficacy data as described in option 2 above.
Option 4. Submitting an Existing Study — The same requirements described for generic data
(see Section lll.C.l" Option 4) apply to this option for product specific data.
Option 5. Upgrading a Study — The same requirements described for generic data (see Section
lll.C.l., Option b) apply to this option for product specific data.
Option 6. Citing Existing Studies — The same requirements described for generic data (see
Section lll.C.l" Option 6) apply to this option for product specific data.
Registrants who select one of the above 6 options must meet all of the requirements
described in the instructions for completing the Data Call-In Response Form and the
Requirements Status and Registrant's Response Form, and in the generic data requirements
section (lll.C.l.), as appropriate.
III-D REQUESTS FOR DATA WAIVERS
1. Generic Data
There are two types of data waiver responses to this Notice. The first is a request for a
low volume/minor use waiver and the second is a waiver request based on your belief that the
data requirement(s) are not appropriate for your product.
a. Low Volume/Minor Use Waiver
Option 8 under item 9 on the Requirements Status and Registrant's Response
Form. Section 3(c)(2)(A) of FIFRA requires EPA to consider the appropriateness of
requiring data for low volume, minor use pesticides. In implementing this provision,
EPA considers low volume pesticides to be only those active ingredients whose total
production volume for all pesticide registrants is small. In determining whether to grant a low
volume, minor use waiver, the Agency will consider the extent, pattern and volume of use, the
economic incentive to conduct the testing, the importance of the pesticide, and the exposure
and risk from use of the pesticide. If an active ingredient is used for both high volume and low
volume uses, a low volume exemption will not be approved. If all uses of an active ingredient
are low volume and the combined volumes for all uses are also low, then an exemption may be
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granted, depending on review of other information outlined below. An exemption will not be
granted if any registrant of the active ingredient elects to conduct the testing. Any registrant
receiving a low volume minor use waiver must remain within the sales figures in their forecast
supporting the waiver request in order to remain qualified for such waiver. If granted a
waiver, a registrant will be required, as a condition of the waiver, to submit annual sales
reports. The Agency will respond to requests for waivers in writing.
To apply for a low volume, minor use waiver, you must submit the following
information, as applicable to your product(s), as part of your 90-day response to this
Notice:
(i). Total company sales (pounds and dollars) of all registered product(s)
containing the active ingredient. If applicable to the active ingredient, include foreign
sales for those products that are not registered in this country but are applied to sugar
(cane or beet), coffee, bananas, cocoa, and other such crops. Present the above
information by year for each of the past five years.
(ii) Provide an estimate of the sales (pounds and dollars) of the active
ingredient for each major use site. Present the above information by year for each of
the past five years.
(iii) Total direct production cost of product (s) containing the active ingredient
by year for the past five years. Include information on raw material cost, direct labor
cost, advertising, sales and marketing, and any other significant costs listed separately.
(iv) Total indirect production cost (e.g. plant overhead, amortized plant and
equipment) charged to product (s) containing the active ingredient by year for the past
five years. Exclude all non-recurring costs that were directly related to the active
ingredient, such as costs of initial registration and any data development.
(v) A list of each data requirement for which you seek a waiver. Indicate the
type of waiver sought and the estimated cost to you (listed separately for each data
requirement and associated test) of conducting the testing needed to fulfill each of these
data requirements.
(vi) A list of each data requirement for which you are not seeking any waiver
and the estimated cost to you (listed separately for each data requirement and associated
test) of conducting the testing needed to fulfill each of these data requirements.
(vii) For each of the next ten years, a year-by-year forecast of company sales
(pounds and dollars) of the active ingredient, direct production costs of product (s)
containing the active ingredient (following the parameters in item 2 above), indirect
production costs of product(s) containing the active ingredient (following the
parameters in item 3 above), and costs of data development pertaining to the active
ingredient.
(viii) A description of the importance and unique benefits of the active
ingredient to users. Discuss the use patterns and the effectiveness of the active
ingredient relative to registered alternative chemicals and non-chemical control
strategies. Focus on benefits unique to the active ingredient, providing information that
is as quantitative as possible. If you do not have quantitative data upon which to base
your estimates, then present the reasoning used to derive your estimates. To assist the
Agency in determining the degree of importance of the active ingredient in terms of its
benefits, you should provide information on any of the following factors, as applicable
to your product(s): (a) documentation of the usefulness of the active ingredient in
Integrated Pest Management, (b) description of the beneficial impacts on the
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environment of use of the active ingredient, as opposed to its registered alternatives,
(c) information on the breakdown of the active ingredient after use and on its
persistence in the environment, and (d) description of its usefulness against a pest(s) of
public health significance.
Failure to submit sufficient information for the Agency to make a determination
regarding a request for a low volume/minor use waiver will result in denial of the
request for a waiver.
b. Request for Waiver of Data
Option 9, under Item 9, on the Requirements Status and Registrant's Response
Form. This option may be used if you believe that a particular data requirement should
not apply because the requirement is inappropriate. You must submit a rationale
explaining why you believe the data requirements should not apply. You also must
submit the current label(s) of your product(s) and, if a current copy of your
Confidential Statement of Formula is not already on file you must submit a current
copy.
You will be informed of the Agency's decision in writing. If the Agency
determines that the data requirements of this Notice are not appropriate to your
product(s), you will not be required to supply the data pursuant to section 3(c)(2)(B). If
EPA determines that the data are required for your product(s) you must choose a ~~
method of meeting the requirements of this Notice within the time frame provided by
this Notice. Within 30 days of your receipt of the Agency's written decision, you must
submit a revised Requirements Status and Registrant s Response Form indicating the
option chosen.
2. Product Specific Data
If you request a waiver for product specific data because you believe it is
inappropriate, you must attach a complete justification for the request including
technical reasons, data and references to relevant EPA regulations, guidelines or
policies. (Note: any supplemental data must be submitted in the format required by PR
Notice 86-5). This will be the only opportunity to state the reasons or provide
information in support of your request. If the Agency approves your waiver request,
you will not be required to supply the data pursuant to section 3(c)(2)(B) of FIFRA. If
the Agency denies your waiver request, you must choose an option for meeting the data
requirements of this Notice within 30 days of the receipt of the Agency's decision.
You must indicate and submit the option chosen on the product specific Requirements
Status and Registrant's Response Form. Product specific data requirements for product
chemistry, acute toxicity and efficacy (where appropriate) are required for all products
and the Agency would grant a waiver only under extraordinary circumstances. You
should also be aware that submitting a waiver request will not automatically extend the
due date for the study in question. Waiver requests submitted~without adequate
supporting rationale will be denied and the original due date will remain in force.
SECTION IV. CONSEQUENCES OF FAILURE TO COMPLY WITH THIS
JMUTICE
IV-A NOTICE OF INTENT TO SUSPEND
The Agency may issue a Notice of Intent to Suspend products subject to this Notice due
to failure by a registrant to comply with the requirements of this Data Call-In Notice, pursuant
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to FIFRA section 3 (c) (2) (B). Events which may be the basis for issuance of a Notice of Intent
to Suspend include, but are not limited to, the following:
1. Failure to respond as required by this Notice within 90 days of your receipt of
this Notice.
2. Failure to submit on the required schedule an acceptable proposed or final
protocol when such is required to be submitted to the Agency for review.
3. Failure to submit on the required schedule an adequate progress report on a
study as required by this Notice.
4. Failure to submit on the required schedule acceptable data as required by this
Notice.
5. Failure to take a required action or submit adequate information pertaining to
any option chosen to address the data requirements (e.g., any required action or
information pertaining to submission or citation of existing studies or offers,
arrangements, or arbitration on the sharing of costs or the formation of Task
Forces, failure to comply with the terms of an agreement or arbitration
concerning joint data development or failure to comply with any terms of a data
waiver).
6. Failure to submit supportable certifications as to the conditions of submitted
studies, as required by Section III-C of this Notice.
7. Withdrawal of an offer to share in the cost of developing required data.
8. Failure of the registrant to whom you have tendered an offer to share in the cost
of developing data and provided proof of the registrant's receipt of such offer
or failure of a registrant on whom you rely for a generic data exemption either
to:
i. Inform EPA of intent to develop and submit the data required by this Notice
on a Data Call-In Response Form and a Requirements Status and Reqistrant's
Response Form.
ii. Fulfill the commitment to develop and submit the data as required by this
Notice; or
iii. Otherwise take appropriate steps to meet the requirements stated in this
Notice,
unless you commit to submit and do submit the required data in the specified
time frame.
9. Failure to take any required or appropriate steps, not mentioned above, at any
time following the issuance of this Notice.
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IV-B. BASIS FOR DETERMINATION THAT SUBMITTED STUDY IS
UNACCEPTABLE
The Agency may determine that a study (even if submitted within the required time) is
unacceptable and constitutes a basis for issuance of a Notice of Intent to Suspend. The grounds
for suspension include, but are not limited to, failure to meet any of the following:
1) EPA requirements specified in the Data Call-In Notice or other documents
incorporated by reference (including, as applicable, EPA Pesticide Assessment
Guidelines, Data Reporting Guidelines, and GeneTox Health Effects Test Guidelines)
regarding the design, conduct, and reporting of required studies. Such requirements
include, but are not limited to, those relating to test material, test procedures, selection
of species, number of animals, sex and distribution of animals, dose and effect levels to
be tested or attained, duration of test, and, as applicable, Good Laboratory Practices.
2) EPA requirements regarding the submission of protocols, including the
incorporation of any changes required by the Agency following review.
3) EPA requirements regarding the reporting of data, including the manner of
reporting, the completeness of results, and the adequacy of any required supporting (or
raw) data, including, but not limited to, requirements referenced or included in this
Notice or contained in PR 86-5. All studies must be submitted in the form of a final
report; a preliminary report will not be considered to fulfill the submission
requirement.
IV-C EXISTING STOCKS OF SUSPENDED OR CANCELLED PRODUCTS
EPA has statutory authority to permit continued sale, distribution and use of existing
stocks of a pesticide product which has been suspended or cancelled if doing so would be
consistent with the purposes of the Act.
The Agency has determined that such disposition by registrants of existing stocks for a
suspended registration when a section 3 (c) (2) (B) data request is outstanding generally would
not be consistent with the Act's purposes. Accordingly, the Agency anticipates granting
registrants permission to sell, distribute, or use existing stocks of suspended product(s) only in
exceptional circumstances. If you believe such disposition of existing stocks of your product (s)
which may be suspended for failure to comply with this Notice should be permitted, you have
the burden of clearly demonstrating to EPA that granting such permission would be consistent
with the Act. You also must explain why an "existing stocks" provision is necessary, including
a statement of the quantity of existing stocks and your estimate of the time required for their
sale, distribution, and use. Unless you meet this burden, the Agency will not consider any
request pertaining to the continued sale, distribution, or use of your existing stocks after
suspension.
If you request a voluntary cancellation of your product(s) as a response to this Notice
and your product is in full compliance with all Agency requirements, you will have, under
most circumstances, one year from the date your 90 day response to this Notice is due, to sell,
distribute, or use existing stocks. Normally, the Agency will allow persons other than the
registrant such as independent distributors, retailers and end users to sell, distribute or use
such existing stocks until the stocks are exhausted. Any sale, distribution or use of stocks of
voluntarily cancelled products containing an active ingredient for which the Agency has
particular risk concerns will be determined on a case-by-case basis.
Requests for voluntary cancellation received after the 90 day response period required
by this Notice will not result in the agency granting any additional time to sell, distribute, or
use existing stocks beyond a year from the date the 90 day response was due, unless you
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demonstrate to the Agency that you are in full compliance with all Agency requirements,
including the requirements of this Notice. For example, if you decide to voluntarily cancel
your registration six months before a 3-year study is scheduled to be submitted, all progress
reports and other information necessary to establish that you have been conducting the study in
an acceptable and good faith manner must have been submitted to the Agency, before EPA
will consider granting an existing stocks provision.
SECTION V. REGISTRANTS' OBLIGATION TO REPORT POSSIBLE UNREASONABLE
ADVERSE EFFECTS
Registrants are reminded that FIFRA section 6 (a) (2) states that if at any time after a
pesticide is registered a registrant has additional factual information regarding unreasonable
adverse effects on the environment by the pesticide, the registrant shall submit the information
to the Agency. Registrants must notify the Agency of any factual information they have, from
whatever source, including but not limited to interim or preliminary results of studies,
regarding unreasonable adverse effects on man or the environment. This requirement
continues as long as the products are registered by the Agency.
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SECTION VI. INQUIRIES AND RESPONSES TO THIS NOTICE
If you have any questions regarding the requirements and procedures established by
this Notice, call the contact person(sj listed in Attachment 1, the Data Call-In Chemical Status
Sheet.
All responses to this Notice must include completed Data Call-in Response Forms
(Attachment 2|and completed Requirements Status and Registrant's Response Forms
(Attachment 3), for both (generic and product specific data) and any other documents required
by this Notice, and should be submitted to the contact person(s) identified in Attachment 1. If
the voluntary cancellation or generic data exemption option is chosen, only the Generic and
Product Specific Data Call-In Response Forms need be submitted.
The Office of Compliance (OC) of the Office of Enforcement and Compliance
Assurance (OECA), EPA, will be monitoring the data being generated in response to this
Notice.
Sincerely yours,
Lois Rossi, Division Director
Special Review and Reregistration Division
Attachments
The Attachments to this Notice are:
1 - Data Call-In Chemical Status Sheet
2 - Generic Data Caii-ln and Product Specific Data Call-In Response Forms with
Instructions
3 - Generic Data Call-In and Product Specific Data Call-In Requirements Status
and Registrant's Response Forms with Instructions
4 - EPA Batching of End-Use Products for Meeting Acute Toxicology Data
Requirements for Reregistration
5 - EPA Acceptance Criteria
6 - List of Registrants Receiving This Notice
7 - Confidential Statement of Formula, Cost Share and Data Compensation Forms
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Attachment 1. Chemical Status Sheets
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DIQUAT DIBROMIDE DATA CALL-IN CHEMICAL STATUS SHEET
INTRODUCTION
You have been sent this Generic Data Call-In Notice because you have product(s)
containing Diquat Dibromide.
This Generic Data Call-In Chemical Status Sheet, contains an overview of data
required by this notice, and point or contact tor inquiries pertaining to the reregistration of
Diquat Dibromide. This attachment is to be used in conjunction with (1) the Generic Data
Call-in Notice, (2) the Generic Data Call-In Response Form (Attachment 2), (3) the
Requirements Status and Registrant's Form (Attachment 2), (4) a list of registrants receiving
this DCI (Attachment 4), (5) the EPA Acceptance Criteria (Attachment 5), and (6) the Cost
Share and Data Compensation Forms in replying to this Diquat Dibromide Generic Data Call
In (Attachment F). Instructions and guidance accompany each form.
DATA REQUIRED BY THIS NOTICE
The additional data requirements needed to complete the generic database for Diquat
Dibromide are contained in the Requirements Status and Registrant's Response, Attachment C.
The Agency has concluded that additional product chemistry data on Diquat Dibromide are
needed. These data are needed to fully complete the reregistration of all eligible Diquat
Dibromide products.
INQUIRIES AND RESPONSES TO THIS NOTICE
If you have any questions regarding the generic data requirements and procedures
established by this Notice, please contact Kylie Rothwell at (703) 308-8055.
All responses to this Notice for the generic data requirements should be submitted to:
Kylie Rothwell, Chemical Review Manager
Special Review and Registration Division (H7508W)
Office of Pesticide Programs
U.S. Environmental Protection Agency
Washington, D.C. 20460
RE: Diquat Dibromide
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DIQUAT DIBROMIDE DATA CALL-IN CHEMICAL STATUS SHEET
INTRODUCTION
You have been sent this Product Specific Data Call-In Notice because you have
product(s) containing Diquat Dibromide.
This Product Specific Data Call-In Chemical Status Sheet contains an overview of data
required by this notice, and point of contact tor inquiries pertaining to the reregistration of
Diquat Dibromide. This attachment is to be used in conjunction with (1) the Product Specific
Data Call-In Notice, (2) the Product Specific Data Call-in Response Form (Attachment 2), (3)
the Requirements Status and Registrant's Form (Attachment 3), (4) EPA's Grouping of End-
Use Products for Meeting Acute Toxicology Data Requirement (Attachment 4), (5) the EPA
Acceptance Criteria (Attachment 5), (6) a list of registrants receiving this DCI (Attachment 6)
and (7) the Cost Share and Data Compensation Forms in replying to this Diquat Dibromide
Product Specific Data Call-In (Attachment 7). Instructions and guidance accompany each
form.
DATA REQUIRED BY THIS NOTICE
The additional data requirements needed to complete the database for Diquat
Dibromide are contained in the Requirements Status and Registrant's Response, Attachment 3.
The Agency has concluded that additional data on Diquat Dibromide are needed for specific
products. These data are required to be submitted to the Agency within the time frame listed.
These data are needed to fully complete the reregistration of all eligible Diquat Dibromide
products.
INQUIRIES AND RESPONSES TO THIS NOTICE
If you have any questions regarding the generic database of Diquat Dibromide, please
contact Kylie Rothwell at (703) 308-8055.
If you have any questions regarding the product specific data requirements and
procedures established by this Notice, please contact Frank Rubis at (703) 308-8184.
All responses to this Notice for the Product Specific data requirements should be
submitted to:
Frank Rubis
Chemical Review Manager Team 81
Product Reregistration Branch
Special Review and Reregistration Branch 7508W
Office of Pesticide Programs
U.S. Environmental Protection Agency
Washington, D.C. 20460
RE: Diquat Dibromide
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Attachment 2. Combined Generic and Product Specific
Data Call-In Response Forms (Form A inserts) Plus
Instructions
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Instructions For Completing The "Data Call-in Response Forms" For The Generic And
Product Specific Data Call-In
INTRODUCTION
These instructions apply to the Generic and Product Specific "Data Call-in Response Forms"
and are to be used by registrants to respond to generic and product specific Data Call-ins as
part of EPA's Reregistration Program under the Federal Insecticide, Fungicide, and
Rodenticide Act. The type of data call-in (generic or product specific) is indicated in item
number 3 ("Date and Type of DCI") on each form. BOTH "Data Call-In Response" forms
must be completed.
Although the form is the same for both generic and product specific data, instructions for
completing these forms are different. Please read these instructions carefully before filling out
the forms.
EPA has developed these forms individually for each registrant, and has preprinted these
forms with a number of items. DO NOT use these forms for any other active ingredient.
Items 1 through 4 have been preprinted on the form. Items 5 through 7 must be completed by
the registrant as appropriate. Items 8 through 11 must be completed by the registrant before
submitting a response to the Agency.
The public reporting burden for this collection of information is estimated to average 15
minutes per response, including time for reviewing instructions, searching existing data
sources, gathering and maintaining the data needed, and completing and reviewing the
collection of information. Send comments regarding the burden estimate or any other aspect of
this collection of information, including suggestions for reducing this burden, to Chief,
Information Policy Branch, Mail Code 213o, U.S. Environmental Protection Agency, 401 M
St., S.W., Washington, D.C. 20460; and to the Office of Management and Budget,
Paperwork Reduction Project 2070-0107, Washington, D.C. 20503.
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INSTRUCTIONS FOR COMPLETING THE DATA CALL-IN RESPONSE FORMS
Generic and Product Specific Data Call-In
Item l.ON BOTH FORMS: This item identifies your company name, number and address.
Item 2.ON BOTH FORMS: This item identifies the case number, case name, EPA chemical
number and chemical name.
Item 3.ON BOTH FORMS: This item identifies the type of Data Call-in. The date of
issuance is date stamped.
Item 4.ON BOTH FORMS: This item identifies the EPA product registrations relevant to
the data call-in. Please note that you are also responsible for informing the Agency of your
response regarding any product that you believe may be covered by this Data Call-In but that
is not listed by the Agency in Item 4. You must bring any such apparent omission to the
Agency's attention within the period required for submission of this response form.
Item 5.ON BOTH FORMS: Check this item for each product registration you wish to cancel
voluntarily. If a registration number is listed for a product for which you previously requested
voluntary cancellation, indicate in Item 5 the date of that request. Since this Data Call-In
requires both generic and product specific data, you must complete item 5 on both Data Call-
in response forms. You do not need to complete any item on the Requirements Status and
Registrant's Response Forms.
Item 6a.ON THE GENERIC DATA FORM: Check this Item if the Data Call-in is for
generic data as indicated in Item 3 and you are eligible for a Generic Data Exemption for the
chemical listed in Item 2 and used in the subject product. By electing this exemption, you
agree to the terms and conditions of a Generic Data Exemption as explained in the Data
Call-in Notice.
If you are eligible for or claim a Generic Data Exemption, enter the EPA registration Number
of each registered source of that active ingredient that you use in your product.
Typically, if you purchase an EPA-registered product from one or more other producers
(who, with respect to the incorporated product, are in compliance with this and any other
outstanding Data Call-In Notice), and
INSTRUCTIONS FOR COMPLETING THE DATA CALL-IN RESPONSE FORMS
Generic and Product Specific Data Caii-ln
incorporate that product into all your products, you may complete this item for all products
listed on this form. If, however, you produce the active ingredient yourself, or use any
unregistered product (regardless of the fact that some of your sources are registered), you may
not claim a Generic Data Exemption and you may not select this item.
Item 6b.ON THE GENERIC DATA FORM: Check this Item if the Data Call-in is for
generic data as indicated in Item 3 and if you are agreeing to satisfy the generic data
requirements of this Data Call-In. Attach the Requirements Status and Registrant's Response
Form that indicates how you will satisfy those requirements.
NOTE: Item 6a and 6b are not applicable for Product Specific Data.
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Item 7a.ON THE PRODUCT SPECIFIC DATA FORM: For each manufacturing use
product (MUP) for which you wish to maintain registration, you must agree to satisfy the data
requirements by responding "yes."
Item Tb.For each end use product (EUP) for which you wish to maintain registration, you
must agree to satisfy the data requirements by responding "yes."
FOR BOTH MUP and EUP products
You should also respond "yes" to this item (7a for MUP's and 7b for EUP's) if your product
is identical to another product and you qualify for a data exemption. You must provide the
EPA registration numbers of your source (s); do not complete the Requirements Status and
Registrant's Response form. Examples of such products include repackaged products and
Special Local Needs (Section 24c) products which are identical to federally registered
products.
If you are requesting a data waiver, answer "yes" here; in addition, on the "Requirements
Status and Registrant's Response" form under Item 9, you must respond with option 7 (Waiver
Request) for each study for which you are requesting a waiver.
NOTE: Item 7 a and 7b are not applicable for Generic Data.
INSTRUCTIONS FOR COMPLETING THE DATA CALL-IN RESPONSE FORMS
Generic and Product Specific Data Caii-ln
Item 8.ON BOTH FORMS: This certification statement must be signed by an authorized
representative of your company and the person signing must include his/her title. Additional
pages used in your response must be initialled and dated in the space provided for the
certification.
Item 9.ON BOTH FORMS: Enter the date of signature.
Item 10.ON BOTH FORMS: Enter the name of the person EPA should contact with
questions regarding your response.
Item 11.ON BOTH FORMS: Enter the phone number of your company contact.
Note: You may provide additional information that does not fit on this form in a signed letter that accompanies your response. For example, you
may wish to report that your product has already been transferred to another company or that you have already voluntarily cancelled this
product. For these cases, please supply all relevant details so that EPA can ensure that its records are correct.
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Attachment 3. Generic and Product Specific Requirement
Status and Registrant's Response Forms (Form B inserts)
and Instructions
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Instructions For Completing The
"Requirements Status and Registrant's Response Forms"
For The Generic and Product Specific Data Call-In
INTRODUCTION
These instructions apply to the Generic and Product Specific "Requirements Status and
Registrant's Response Forms" and are to be used by registrants to respond to generic and
product specific Data Call-in's as part of EPA's reregistration program under the Federal
Insecticide, Fungicide, and Rodenticide Act. The type of Data Call-in (generic or product
specific) is indicated in item number 3 ("Date and Type of DCI") on each form. Both
"Requirements Status and Registrant's Response" forms must be completed.
Although the form is the same for both product specific and generic data, instructions
for completing the forms differ slightly. Specifically, options for satisfying product specific
data requirements do not include (1) deletion of uses or (2) request for a low volume/minor
use waiver. Please read these instructions carefully before filling out the forms.
EPA has developed these forms individually for each registrant, and has preprinted
these forms to include certain information unique to this chemical. DO NOT use these forms
for any other active ingredient.
Items 1 through 8 have been preprinted on the form. Item 9 must be completed by the
registrant as appropriate. Items 10 through 13 must be completed by the registrant before
submitting a response to the Agency.
The public reporting burden for this collection of information is estimated to average
30 minutes per response, including time for reviewing instructions, searching existing data
sources, gathering and maintaining the data needed, and completing and reviewing the
collection of information. Send comments regarding the burden estimate or any other aspect of
this collection of information, including suggestions for reducing this burden, to Chief,
Information Policy Branch, Mail Code 213TH U.S. Environmental Protection Agency, 401 M
St., S.W., Washington, D.C. 20460; and to the Office of Management and Budget,
Paperwork Reduction Project 2070-0107, Washington, D.C. 20503.
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INSTRUCTIONS FOR COMPLETING THE "REQUIREMENTS STATUS AND
REGISTRANT'S RESPONSE FORMS"
Generic and Product Specific Data Call-in
Item 1. ON BOTH FORMS: This item identifies your company name, number and
address.
Item 2. ON THE GENERIC DATA FORM: This item identifies the case number,
case name, EPA chemical number and chemical name.
ON THE PRODUCT SPECIFIC DATA FORM: This item identifies the
case number, case name, and the EPA Registration Number of the product for
which the Agency is requesting product specific data.
Item 3. ON THE GENERIC DATA FORM: This item identifies the type of Data
Call-In. The date of issuance is date stamped.
ON THE PRODUCT SPECIFIC DATA FORM: This item identifies the type
of Data Call-In. The date of issuance is also date stamped. Note the unique
identifier number (ID#) assigned by the Agency. This ID number must be used
in the transmittal document for any data submissions in response to this Data
Call-In Notice.
Item 4. ON BOTH FORMS: This item identifies the guideline reference number of
studies required. These guidelines, in addition to the requirements specified in
the Data Call-in Notice, govern the conduct of the required studies. Note that
series 61 and 62 in product chemistry are now listed under 40 CFR 158.155
through 158.180, Subpart c.
Item 5. ON BOTH FORMS: This item identifies the study title associated with the
guideline reference number and whether protocols and 1, 2, or 3-year progress
reports are required to be submitted in connection with the study. As noted in
Section III of the Data Call-In Notice, 90-day progress reports are required for
all studies.
If an asterisk appears in Item 5, EPA has attached information relevant to this
guideline reference number to the Requirements Status and Registrant's
Response Form.
INSTRUCTIONS FOR COMPLETING THE "REQUIREMENTS STATUS AND
REGISTRANT'S RESPONSE HJRMS"
Generic and Product Specific Data Caii-ln
Item 6. ON BOTH FORMS: This item identifies the code associated with the use
pattern of the pesticide. In the case of efficacy data (product specific
requirement), the required study only pertains to products which have the use
sites and/or pests indicated. A brief description of each code follows:
A Terrestrial food
B Terrestrial feed
C Terrestrial non-food
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Item 7.
Item 8.
D Aquatic food
E Aquatic non-food outdoor
F Aquatic non-food industrial
G Aquatic non-food residential
H Greenhouse food
I Greenhouse non-food crop
J Forestry
K Residential
L Indoor food
M Indoor non-food
N Indoor medical
0 Indoor residential
ON BOTH FORMS: This item identifies the code assigned to the substance
that must be used for testing. A brief description of each code follows:
EUP
MP
MP/TGAI
PAI
PAI/M
PAI/PAIRA
PAIRA
PAIRA/M
PAIRA/PM
TEP
TEP %
TEP/MET
TEP/PAI/M
TGAI
TGAI/PAI
TGAI/PAIRA
TGAI/TEP
MET
IMP
DEGR
End-Use Product
Manufacturing-Use Product
Manufacturing-Use Product and Technical Grade Active
Ingredient
Pure Active Ingredient
Pure Active Ingredient and Metabolites
Pure Active Indredient or Pute Active
Ingredient Radiolabelled
Pure Active Ingredient Radiolabelled
Pure Active Ingredient Radiolabelled and Metabolites
Pure Active Ingredient Radiolabelled and Plant
Metabolites
Typical End-Use Product
Typical End-Use Product, Percent Active Ingredient
Specified
Typical End-Use Product and Metabolites
Typical End-Use Product or Pure Active Ingredient and
Metabolites
Technical Grade Active Ingredient
Technical Grade Active Ingredient or Pure Active
Ingredient
Technical Grade Active Ingredient or Pure Active
Ingredient Radiolabelled
Technical Grade Active Ingredient or Typical End-Use
Product
Metabolites
Impurities
Degradates
See: guideline comment
This item completed by the Agency identifies the time frame allowed for
submission of the study or protocol identified in item 5.
ON THE GENERIC DATA FORM: The time frame runs from the date of
your receipt of the Data Call-In notice.
ON THE PRODUCT SPECIFIC DATA FORM: The due date for
submission of product specific studies begins from the date stamped on the letter
transmitting the Reregistration Eligibility Decision document, and not from the
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date of receipt. However, your response to the Data Call-in itself is due 90
days from the date of receipt.
Item 9. ON BOTH FORMS: Enter the appropriate Response Code or Codes to show
how you intend to comply with each data requirement. Brief descriptions of
each code follow. The Data Call-In Notice contains a fuller description of each
of these options.
Option 1. ON BOTH FORMS: (Developing Data) I will conduct a new study and
submit it within the time frames specified in item 8 above. By indicating
that I have chosen this option, I certify that I will comply with all the
requirements pertaining to the conditions for submittal of this study as
outlined in the Data Call-In Notice and that I will provide the protocols
and progress reports required in item 5 above.
Option 2. ON BOTH FORMS: (Agreement to Cost Share) I have entered into an
agreement with one or more registrants to develop data jointly. By
indicating that I have chosen this option, I certify that I will comply with
all the requirements pertaining to sharing in the cost of developing data
as outlined in the Data Call-In Notice.
However, for Product Specific Data, I understand that this
option is available for acute toxicity or certain efficacy data ONLY if
the Agency indicates in an attachment to this notice that my product is
similar enough to another product to qualify for this option. I certify that
another party in the agreement is committing to submit or provide the
required data; if the required study is not submitted on time, my product
may be subject to suspension.
Option 3. ON BOTH FORMS: (Offer to Cost Share) I have made an offer to
enter into an agreement with one or more registrants to develop data
jointly. I am also submitting a completed "Certification of offer to Cost
Share in the Development of Data" form. I am submitting evidence that
I have made an offer to another registrant (who has an obligation to
submit data) to share in the cost of that data. I am including a copy of
my offer and proof of the other registrant's receipt of that offer. I am
identifying the party which is committing to submit or provide the
required data; if the required study is not submitted on time, my product
may be subject to suspension. I understand that other terms under Option
3 in the Data Call-In Notice apply as well.
However, for Product Specific Data, I understand that this
option is available only for acute toxicity or certain efficacy data and
only if the Agency indicates in an attachment to this Data Call-In Notice
that my product is similar enough to another product to qualify for this
option.
Option 4. ON BOTH FORMS: (Submitting Existing Data) I will submit an
existing study by the specified due date that has never before been
submitted to EPA. By indicating that I have chosen this option, I certify
that this study meets all the requirements pertaining to the conditions for
submittal of existing data outlined in the Data CalHn Notice and I have
attached the needea supporting information along with this response.
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Options. ON BOTH FORMS: (Upgrading a Study) I will submit by the
specified due date, or will cite data to upgrade a study that EPA has
classified as partially acceptable and potentially upgradeable. By
indicating that I have chosen this option, I certify that I have met all the
requirements pertaining to the conditions for submitting or citing
existing data to upgrade a study described in the Data Call-in Notice. I
am indicating on attached correspondence the Master Record
Identification Number (MRID) that EPA has assigned to the data that I
am citing as well as the MRID of the study I am attempting to upgrade.
Option 6. ON BOTH FORMS: (Citing a Study) I am citing an existing study
that has been previously classified by EPA as acceptable, core, core
minimum, or a study that has not yet been reviewed by the Agency. If
reviewed, I am providing the Agency's classification of the study.
However, for Product Specific Data, I am citing another
registrant's study. I understand that this option is available ONLY for
acute toxicity or certain efficacy data and ONLY if the cited study was
conducted on my product, an identical product or a product which the
Agency has "grouped" with one or more other products for purposes of
depending on the same data. I may also choose this option if I am citing
my own data. In either case, I will provide the MRID or Accession
number (s). If I cite another registrant's data, I will submit a completed
"Certification With Respect To Data Compensation Requirements"
form.
FOR THE GENERIC DATA FORM ONLY: The following three options
(Numbers 7,8, and U) are responses that apply only to the 'Requirements Status
and Registrant's Response Form" for generic data.
Option 7. (Deleting Uses) I am attaching an application for amendment to my
registration deleting the uses for which the data are required.
Option 8. (Low Volume/Minor Use Waiver Request) I have read the statements
concerning low volume-minor use data waivers in the Data Call-In
Notice and I request a low-volume minor use waiver of the data
requirement. I am attaching a detailed justification to support this waiver
request including, among other things, all information required to
support the request. I understand that, unless modified by the Agency in
writing, the data requirement as stated in the Notice governs.
Option 9. (Request for Waiver of Data) I have read the statements concerning data
waivers other than lowvolume minor-use data waivers in the Data
Call-In Notice and I request a waiver of the data requirement. I am
attaching a rationale explaining why I believe the data requirements do
not apply. I am also submitting a copy of my current labels. (You must
also submit a copy of your Confidential Statement of Formula if not
already on file with EPA). I understand that, unless modified by the
Agency in writing, the data requirement as stated in the Notice governs.
FOR PRODUCT SPECIFIC DATA: The following option (number 7) is a
response that applies to the "Requirements Status and Registrant's Response
Form" for product specific data.
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Option 7. (Waiver Request) I request a waiver for this study because it is
inappropriate tor my product. I am attaching a complete justification for
this request, including technical reasons, data and references to relevant
EPA regulations, guidelines or policies. [Note: any supplemental data
must be submitted in the format required by P.R. Notice 86-5]. I
understand that this is my only opportunity to state the reasons or
provide information in support of my request. If the Agency approves
my waiver request, I will not be required to supply the data pursuant to
Section 3(c) (2) (B) of FIFRA. If the Agency denies my waiver request,
I must choose a method of meeting the data requirements of this Notice
by the due date stated by this Notice. In this case, I must, within 30
days-of my receipt of the Agency's written decision, submit a revised
"Requirements Status" form specifying the option chosen. I also
understand that the deadline for submission of data as specified by the
original Data Call-In notice will not change.
Item 10. ON BOTH FORMS: This item must be signed by an authorized representative
of your company. The person signing must include his/her title, and must initial
and date all other pages of this form.
Item 11. ON BOTH FORMS: Enter the date of signature.
Item 12. ON BOTH FORMS: Enter the name of the person EPA should contact with
questions regarding your response.
Item 13. ON BOTH FORMS: Enter the phone number of your company contact.
NOTE: You may provide additional information that does not fit on this form in a signed letter that accompanies this your response. For example,
you may wish to report that your product has already been transferred to another company or that you have already voluntarily cancelled
244
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Attachment 4. EPA Batching of End-Use Products for
Meeting Data Requirements for Reregistration
245
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246
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EPA'S BATCHING OF DIQUAT DIBROMIDE END-USE PRODUCTS FOR MEETING
ACUTE TOXICITY DATA REQUIREMENTS FOR REREGISTRATION
In an effort to reduce the time, resources and number of animals needed to fulfill the acute
toxicity data requirements for reregistration of end-use products containing the active
ingredient diquat dibromide [6,7-dihydrodipyrido (l,2-a:2 ,1 -c) pyrazinediium dibromide],
the Agency has batched products which can be considered similar for purposes of acute
toxicity. Factors considered in the sorting process include each product's active and inert
ingredients (identity, percent composition and biological activity), type of formulation (e.g.,
emulsifiable concentrate, aerosol, wettable powder, granular, etc.), and labeling (e.g., signal
word, use classification, precautionary labeling, etc.). Note that the Agency is not describing
batched products as "substantially similar" since some products within a batch may not be
considered chemically similar or have identical use patterns.
Batching has been accomplished using the readily available information described above.
Frequently acute toxicity data on individual end-use products has been found to be incomplete.
Notwithstanding the batching process, the Agency reserves the right to require, at any time,
acute toxicity data for an individual end-use product should the need arise.
Registrants of end-use products within a batch may choose to cooperatively gener- ate,
submit or cite a single battery of six acute toxicological studies to represent all the products
within that batch. It is the registrants' option to participate in the process with all other
registrants, only some of the other registrants, or only their own products within a batch, or to
generate all the required acute toxicological studies for each of their own products. If a
registrant chooses to generate the data for a batch, he/she must use one of the products within
the batch as the test material. If a registrant chooses to rely upon previously submitted acute
toxicity data, he/she may do so provided that the data base is complete and valid by today's
standards (see acceptance criteria attached), the formul- ation tested is considered by EPA to
be similar for acute toxicity, and the formulation has not been significantly altered since
submission and acceptance of the acute toxicity data. Regardless of whether new data is
generated or existing data is cited, the registrant must clearly identify the material tested by its
EPA registration number. If more than one Confidential Statement Of Formula (CSF) exists
for a product registration, the registrant must indicate the formulation actually tested by
identifying the corresponding CSF.
In deciding how to meet the product specific data requirements, registrants must follow the
directions given in the Data Call-In Notice and its attachments appended to the RED. The DCI
Notice contains two response forms which are to be completed and submitted to the Agency
within 90 days of receipt. The first form, "Data Call-In Response," asks whether the
registrant will meet the data requirements for each product. The second form, "Requirements
Status and Registrant's Response," lists the product specific data required for each product,
including the standard six acute toxicity tests. A registrant who wishes to participate in a
batch must decide whether he/she will provide the data or depend on someone else to do so.
If a registrant supplies the data to support a batch of products, he/she must select one of the
following options: Developing Data (Option 1), Submitting an Existing Study (Option 4),
Upgrading an Existing Study (Option 5j or Citing an Existing Study (Option 6). If a registrant
depends on another's data, he/she must choose among: Cost Sharing (Option 2), Offers to
Cost Share (Option 3) or Citing an Existing Study (Option 6). If a registrant does not want to
participate in a batch, the choices are Options 1, 4, 5 or 6. However, a registrant should
know that choosing not to participate in a batch does not preclude other registrants in the batch
from citing his/her studies and offering to cost share (Option 3) those studies.
The following information (Table I) lists thirty five products (four batches) containing
diquat dibromide.
247
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Table T: Batched Products.
Batch No.
1.
2.
3.
4.
EPA Reg. No.
192-177
478-114
769-945
802-572
9404-75
10583-10
46515-14
46515-15
46515-16
192-178
802-582
1685-64
1769-174
2155-43
2155-63
2155-64
8123-37
10088-13
10088-35
10663-11
11515-29
37347-6
48211-23
8123-102
9250-16
10182-356
10182-377
10827-78
34704-589
10182-353
10182-354
10182-355
10182-375
10182-376
10182-378
% Diquat
dibromide
.23
.23
.23
.23
.23
.23
.09
.19
.23
1.84
1.84
2.36
1.85
1.85
1.85
1.85
1.85
1.85
1.85
1.85
1.85
1.85
1.85
4.35
4.35
4.35
4.35
4.35
4.35
36.4
37.45
35.3
35.3
35.3
37.45
Formulation Type
Ready-To-Use Solution (RTUS)
RTUS
RTUS
RTUS
RTUS
RTUS
RTUS
RTUS
RTUS
Emulsifiable Concentrate (EC)
RTUS
EC
EC
EC
EC
EC
EC
SC
SC
SC
SC
SC
SC
SC
SC
SC
SC
SC
SC
SC
Formulation Intermediate (FI)
FI
SC
FI
FI
Seven products (Table II) were either considered not to be similar for purposes of acute
toxicity or the Agency lacked sufficient information for decision making, and not placed in
any batch. Registrants of these products are responsible for meeting the acute toxicity data
requirements for each product.
248
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Table TT: Products Not Batched
EPA Reg.
Number
228-201
491-201
5080-4
5197-37
8959-9
9688-93
10583-22
% Diquat
dibromide plus other active
ingredient
.154 diquat dibromide
2.3 sodium chlorate
2.38 diquat dibromide
8.54 diquat dibromide
2. 16 diquat dibromide
8.53 diquat dibromide
2. 3 diquat dibromide
2.7 diquat dibromide
Formulation Type
RTUS
EC
SC
EC
SC
SC
SC
249
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250
-------
Attachment 5. EPA Acceptance Criteria
251
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252
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SUBDIVISION D
Guideline Study Title
Series 61 Product Identity and Composition
Series 62 Analysis and Certification of Product Ingredients
Series 63 Physical and Chemical Characteristics
253
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61 Product Identity and Composition
ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
1. Name of technical material tested (include product name and trade name, if appropriate).
2. Name, nominal concentration, and certified limits (upper and lower) for each active ingredient and each
intentionally-added inert ingredient.
3. Name and upper certified limit for each impurity or each group of impurities present at _>_ 0.1% by weight
and for certain lexicologically significant impurities (e.g., dioxins, nitrosamines) present at < 0.1%.
4. Purpose of each active ingredient and each intentionally-added inert.
5. Chemical name from Chemical Abstracts index of Nomenclature and Chemical Abstracts Service (CAS)
Registry Number for each active ingredient and, if available, for each intentionally-added inert.
6. Molecular, structural, and empirical formulas, molecular weight or weight range, and any company
assigned experimental or internal code numbers for each active ingredient.
7. Description of each beginning material in the manufacturing process.
EPA Registration Number if registered;
for other beginning materials, the following:
Name and address of manufacturer or supplier.
Brand name, trade name or commercial designation.
Technical specifications or data sheets by which manufacturer or supplier describes composition,
properties or toxicity.
8. Description of manufacturing process.
Statement of whether batch or continuous process.
Relative amounts of beginning materials and order in which they are added.
Description of equipment.
Description of physical conditions (temperature, pressure, humidity) controlled in each step and the
parameters that are maintained.
Statement of whether process involves intended chemical reactions.
Flow chart with chemical equations for each intended chemical reaction.
Duration of each step of process.
Description of purification procedures.
Description of measures taken to assure quality of final product.
9. Discussion of formation of impurities based on established chemical theory addressing (1) each impurity
which may be present at _>_ 0.1% or was found at _>_ 0.1% by product analyses and (2) certain
lexicologically significant impurities (see #3).
254
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62 Analysis and Certification of Product Ingredients
ACCEPTANCE CRITERIA
The following criteria apply to the technical grade of the active ingredient being reregistered. Use a table to present
the information in items 6, 7, and 8.
Does your study meet the following acceptance criteria?
1. Five or more representative samples (batches in case of batch process) analyzed for each active ingredient
and all impurities present at > ff. 1%.
2. Degree of accountability or closure _>^ ca 98%.
3. Analyses conducted for certain trace toxicTmpurities at lower than 0.1% (examples, nitrosamines in the case
of products containing dinitroanilines or containing secondary or tertiary amines/alkanolamines plus nitrites;
polyhalogenated dibenzodioxins and dibenzofurans). [Note that in the case of nitrosamines both fresh and
stored samples must be analyzed.].
4. Complete and detailed description of each step in analytical method used to analyze above samples.
5. Statement of precision and accuracy of analytical method used to analyze above samples.
6. Identities and quantities (including mean and standard deviation) provided for each analyzed ingredient.
7. Upper and lower certified limits proposed for each active ingredient and intentionally added inert along with
explanation of how the limits were determined.
8. Upper certified limit proposed for each impurity present at j>_ 0.1% and for certain lexicologically significant
impurities at < 0.1% along with explanation of how linnTdetermined.
9. Analytical methods to verify certified limits of each active ingredient and impurities (latter not required if
exempt from requirement of tolerance or if generally recognized as safe by FDA) are fully described.
10. Analytical methods (as discussed in #9) to verify certified limits validated as to their precision and accuracy.
255
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63 Physical and Chemical Characteristics
ACCEPTANCE CRITERIA
The following criteria apply to the technical grade of the active ingredient being reregistered.
Does your study meet the following acceptance criteria?
63-2 Color
Verbal description of coloration (or lack of it)
Any intentional coloration also reported in terms of Munsell color system
63-3 Physical State
Verbal description of physical state provided using terms such as "solid, granular, volatile liquid"
Based on visual inspection at about 20-25° C
63-4 Odor
Verbal description of odor (or lack of it) using terms such as "garlic-like, characteristic of aromatic
compounds"
Observed at room temperature
63-5 Melting Point
Reported in ° C
Any observed decomposition reported
63-6 Boiling Point
Reported in ° C
Pressure under which B.P. measured reported
Any observed decomposition reported
63-7 Density, Bulk Density, Specific Gravity
Measured at about 20-25° C
Density of technical grade active ingredient reported in g/ml or the specific gravity of liquids reported with
reference to water at 20° C. [Note: Bulk density of registered products may be reported in lbs/ft3 or
Ibs/gallon.]
63-8 Solubility
Determined in distilled water and representative polar and non-polar solvents, including those used in
formulations and analytical methods for the pesticide
Measured at about 20-25° C
Reported in g/100 ml (other units like ppm acceptable if sparingly soluble)
63-9 Vapor Pressure
Measured at 25° C (or calculated by extrapolation from measurements made at higher temperature if
pressure too low to measure at 25° C)
Experimental procedure described
Reported in mm Hg (torr) or other conventional units
63-10 Dissociation Constant
Experimental method described
Temperature of measurement specified (preferably about
20-25 °C)
63-11 Octanol/water Partition Coefficient
Measured at about 20-25° C
Experimentally determined and description of procedure provided (preferred method-45 Fed. Register
Data supporting reported value provided
63-12 pH
Measured at about 20-25° C
Measured following dilution or dispersion in distilled water
63-13 Stability
Sensitivity to metal ions and metal determined
Stability at normal and elevated temperatures
Sensitivity to sunlight determined
256
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SUBDIVISION F
Guideline Study Tide
81-1 Acute Oral Toxicity in the Rat
81-2 Acute Dermal Toxicity in the Rat, Rabbit or Guinea Pig
81-3 Acute Inhalation Toxicity in the Rat
81-4 Primary Eye Irritation in the Rabbit
81-5 Primary Dermal Irritation Study
81-6 Dermal Sensitization in the Guinea Pig
257
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81-1 Acute Oral Toxicity in the Rat
ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
1. Identify material tested (technical, end-use product, etc).
2. At least 5 young adult rats/sex/group.
3.r Dosing, single oral may be administered over 24 hrs.
4.*^ Vehicle control if other than water.
5. Doses tested, sufficient to determine a toxicity category or a limit dose (5000 mg/kg).
6. Individual observations at least once a day.
7. Observation period to last at least 14 days, or until all test animals appear normal whichever is longer.
8. Individual daily observations.
9. Individual body weights.
10. Gross necropsy on all animals.
Criteria marked with an * are supplemental and may not be required for every study.
ental an
258
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81-2 Acute Dermal toxicity in the Rat, Rabbit or Guinea Pig
ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
1. Identify material tested (technical, end-use product, etc).
2. At least 5 animals/sex/group.
3.* Rats 200-300 gm, rabbits 2.0-3.0 kg or guinea pigs 350-450 gm.
4. Dosing, single dermal.
5. Dosing duration at least 24 hours.
6.^ Vehicle control, only if toxicity of vehicle is unknown.
7.~ Doses tested, sufficient to determine a toxicity category or a limit dose (2000 mg/kg).
8. Application site clipped or shaved at least 24 hours oefore dosing.
9. Application site at least 10% of body surface area.
10. Application site covered with a porous nonirritating cover to retain test material and to prevent
ingestion.
11. Individual observations at least once a day.
12. Observation period to last at least 14 days.
13. Individual body weights.
14. Gross necropsy on all animals.
Criteria marked with an * are supplemental and may not be required for every study.
-------
81-3 Acute Inhalation Toxicity in the Rat
ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
1. Identify material tested (technical, end-use product, etc).
2. Product is a gas, a solid which may produce a significant vapor hazard based on toxicity and expected use
or contains particles of inhalable size for man (aerodynamic diameter 15 pm or less).
3. At least 5 young adult rats/sex/group.
4. Dosing, at least 4 hours by inhalation.
5. Chamber air flow dynamic, at least 10 air changes/hour, at least 19% oxygen content.
6. Chamber temperature, 22° C (+_2°), relative humidity 40-60%.
7. Monitor rate of air flow.
8. Monitor actual concentrations of test material in breathing zone.
9. Monitor aerodynamic particle size for aerosols.
10. Doses tested, sufficient to determine a toxicity category or a limit dose (5 mg/L actual concentration of
respirable substance).
11. Individual observations at least once a day.
12. Observation period to last at least 14 days.
13. Individual body weights.
14. Gross necropsy on all animals.
260
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81-4 Primary Eye Irritation in the Rabbit
ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
1. Identify material tested (technical, end-use product, etc).
2. Study not required if material is corrosive, causes severe
dermal irritation or has a pH of < 2 or > 11.5.
3. 6 adult rabbits.
4. Dosing, instillation into the conjunctival sac of one eye
per animal.
5. Dose, 0.1 ml if a liquid; 0.1 ml or not more than 100 mg if a solid, paste or particulate substance.
6. Solid or granular test material ground to a fine dust.
7. Eyes not washed for at least 24 hours.
8. Eyes examined and graded for irritation before dosing and
at 1, 24, 48 and 72 hr, then daily until eyes are normal
or 21 days (whichever is shorter).
9.^ Individual daily observations.
Criteria marked with an * are supplemental and may not be required for every study.
-------
81-5 Primary Dermal Irritation Study
ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
1. Identify material tested (technical, end-use product, etc).
2. Study not required if material is corrosive or has a pH of < 2 or > 11.5.
3. 6 adult animals.
4. Dosing, single dermal.
5. Dosing duration 4 hours.
6. Application site shaved or clipped at least 24 hours prior to dosing.
7. Application site approximately 6 cm2.
8. Application site covered with a gauze patch held in place with nonirritating tape.
9. Material removed, washed with water, without trauma to application site.
10. Application site examined and graded for irritation at 1, 24, 48 and 72 hr, then daily until normal or 14 days
(whichever is shorter).
11.^ Individual daily observations.
Criteria marked with an * are supplemental and may not be required for every study.
262
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81-6 Dermal Sensitization in the Guinea Pig
ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?
1. Identify material tested (technical, end-use product, etc).
2. Study not required if material is corrosive or has a
pHof <2or >11.5.
3. One offhe following methods is utilized:
Freund's complete adjuvant test
Guinea pig maximization test
Split adjuvant technique
Buehler test
Open epicutaneous test
Mauer optimization test
Footpad technique in guinea pig.
4. Complete description of test.
5.^ Reference for test.
G.~ Test followed essentially as described in reference document.
7. Positive control included (may provide historical data conducted within the last 6 months).
Criteria marked with an * are supplemental and may not be required for every study.
263
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264
-------
Attachment 6. List of All Registrants Sent This Data Call-In (insert)
Notice
265
-------
266
-------
Attachment 7. Cost Share, Data Compensation Forms, Confidential
Statement of Formula Form and Instructions
267
-------
268
-------
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270
-------
Instructions for Completing the Confidential Statement of Formula
The Confidential Statement of Formula (CSF) Form 8570-4 must be used. Two legible, signed copies of the form are
required. Following are basic instructions:
a. All the blocks on the form must be filled in and answered completely.
b. If any block is not applicable, mark it N/A.
c. The CSF must be signed, dated and the telephone number of the responsible party must be provided.
d. All applicable information which is on the product specific data submission must also be reported on the
CSF.
e. All weights reported under item 7 must be in pounds per gallon for liquids and pounds per cubic feet
for solids.
f. Flashpoint must be in degrees Fahrenheit and flame extension in inches.
g. For all active ingredients, the EPA Registration Numbers for the currently registered source products
must be reported under column 12.
h. The Chemical Abstracts Service (CAS) Numbers for all actives and inerts and all common names for
the trade names must be reported.
i. For the active ingredients, the percent purity of the source products must be reported under column 10
and must be exactly the same as on the source product's label.
j. All the weights in columns 13.a. and 13.b. must be in pounds, kilograms, or grams. In no case will
volumes be accepted. Do not mix English and metric system units (i.e., pounds and kilograms).
k. All the items under column 13.b. must total 100 percent.
1. All items under columns 14.a. and 14.b. for the active ingredients must represent pure active form.
m. The upper and lower certified limits for ail active and inert ingredients must follow the 40 CFR 158.175
instructions. An explanation must be provided if the proposed limits are different than standard certified
limits.
n. When new CSFs are submitted and approved, all previously submitted CSFs become obsolete for that
specific formulation.
271
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272
-------
&EPA
United States Environmental Protection Agency
Washington, DC 20460
CERTIFICATION OF OFFER TO COST
SHARE IN THE DEVELOPMENT OF DATA
Form Approved
OMB No. 2070-0106
2070-0057
Approval Expires 3-31-96
Public reporting burden for this collection of information is estimated to average 15 minutes per response, including
time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and
completing and reviewing the collection of information. Send comments regarding the burden estimate or any other
aspect of this collection of information, including suggestions for reducing this burden, to Chief, Information Policy
Branch, PM-223, U.S. Environmental Protection Agency, 401 M St., S.W., Washington, DC 20460; and to the Office
of Management and Budget, Paperwork Reduction Project (2070-0106), Washington, DC 20503.
Please fill in blanks below.
Company Maine
Product Name
Company Number
EPA Reg. No.
I Certify that:
My company is willing to develop and submit the data required by EPA under the authority of the Federal
Insecticide, Fungicide and Rodenticide Act (FIFRA), if necessary. However, my company would prefer to
enter into an agreement with one or more registrants to develop jointly or share in the cost of developing
data.
My firm has offered in writing to enter into such an agreement. That offer was irrevocable and included an
offer to be bound by arbitration decision under section 3(c)(2)(B)(iii) of FIFRA if final agreement on all
terms could not be reached otherwise. This offer was made to the following firm(s) on the following
date(s):
Name of Firm(s)
Date of Offer
Certification:
I certify that I am duly authorized to represent the company named above, and that the statements that I have made on
this form and all attachments therein are true, accurate, and complete. I acknowledge that any knowingly false or
misleading statement may be punishable by fine or imprisonment or both under applicable law.
Signature of Company's Authorized Representative
Date
Name and Title (Please Type or Print)
EPA Form 8570-32 (5/91) Replaces EPA Form 8580, which is obsolete
273
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274
-------
United States Environmental Protection Agency
Washington, DC 20460
CERTIFICATION WITH RESPECT TO
DATA COMPENSATION REQUIREMENTS
Form Approved
OMB No. 2070-0107,
2070-0057
Approval Expires
3-31-96
Public reporting burden for this collection of information is estimated to average 15 minutes per response, including time for
reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the
collection of information. SencTcomments regarding the burden estimate or any other aspect of this collection of information,
including suggestions for reducing this burden to, Chief Information Policy Branch, PM-233, U.S. Environmental Protection
Agency, 401 M St., S.W., Washington, DC 20460; and to the Office of Management and Budget, Paperwork Reduction Project
(2070-0106), Washington, DC 20503.
Please fill in blanks below.
Company Name
Product Name
Company Number
EPA Reg. No.
I Certify that:
1. For each study cited in support of registration or reregistratiion under the Federal Insecticide, Fungicide and Rodentipide Act
(FIFRA) that is an exclusive use study, I am the original data submitter, or I have obtained the written permission of the original
data submitter to cite that study.
2. That for each study cited in support of registration or reregistration under FIFRA that is NOT an exclusive use study, I am the
original data submitter, or I have obtained the written permission of the original data submitter, or I have notified in writing the
company(ies) that submitted data I have cited and have offered to: (a) Pay cpmpensation for those data in accordance with sections
3(c)(1)(F) and 3(c)(2)(D) of FIFRA; and (b) Commence negotiation to determine which data are subject to the compensation
requirement of FlFRA and the amount of compensation due, if any. The companies I have notified are. (check one)
[ ] The companies who have submitted the studies listed on the back of this form or attached sheets, or indicated on the attached
"Requirements Status and Registrants' Response Form,"
3. That I have previously complied with section 3(c)(1)(F) of FIFRA for the studies I have cited in support of registration or
reregistration under FIFRA.
Signature
Date
Name and Title (Please Type or Print)
GENERAL OFFER TO PAY: I hereby offer and agree to pay compensation to other persons, wi
reregistration of my products, to the extent required by FIFRA section 3(c)(1)(F) and 3(c)(2)(D).
with regard to the registration or
Signature
Date
Name and Title (Please Type or Print)
EPA Form 8570-31 (4-96)
275
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276
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APPENDIX G. FACT SHEET
277
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278
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United States
Environmental Protection
Agency
Prevention, Pesticides
And Toxic Substances
(7508W)
EPA-738-F-95-015
July 1995
R.E.D. FACTS
Pesticide
Reregistration
Use Profile
Diquat Dibromide
All pesticides sold or distributed in the United States must be registered
by EPA, based on scientific studies showing that they can be used without
posing unreasonable risks to people or the environment. Because of advances
in scientific knowledge, the law requires that pesticides which were first
registered years ago be reregistered to ensure that they meet today's more
stringent standards.
In evaluating pesticides for reregi strati on, EPA obtains and reviews a
complete set of studies from pesticide producers, describing the human health
and environmental effects of each pesticide. The Agency imposes any
regulatory controls that are needed to effectively manage each pesticide's
risks. EPA then reregisters pesticides that can be used without posing
unreasonable risks to human health or the environment.
When a pesticide is eligible for reregi strati on, EPA announces this and
explains why in a Reregi strati on Eligibility Decision (RED) document. This
fact sheet summarizes the information in the RED document for reregi strati on
case 0288, diquat dibromide.
Diquat dibromide is a non-selective contact herbicide, algicide,
desiccant, and defoliant. As a herbicide/algicide, it is used to control
broadleaf and grassy weeds in non-crop (including residential) and aquatic
areas. As a desiccant/ defoliant, it is used in seed crops and potatoes. Its
largest use is as a desiccant on potato crops.
Diquat dibromide is formulated as a soluble concentrate and ready-to-
use liquid. As a herbicide, it is applied using a hand-held or mechanical
sprayer; as an algicide, it is injected below the water surface to control
submerged weeds. When used as a desiccant, it may be applied by aircraft or
ground equipment. Applications in crop areas are made five days to two
weeks before harvest.
Use practice limitations include...
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Regulatory
History
Human Health
Assessment
Diquat dibromide is the common name for 6,7-dihydrodipyrido (1,2-
a:2',l'-c) pyrazinediium dibromide. The manufacture of diquat dibromide
may result in the formation of ethylene dibromide (EDB) as a process
impurity. EDB is considered a carcinogen, and all pesticide uses have been
cancelled. EPA assessed the potential exposure risks of diquat dibromide and
concluded in June 1986 that the presence of EDB does not pose a significant
dietary risk, based on worst case assumptions. In addition, the registrant
certified an upper limit of 10 parts per billion for EDB in diquat dibromide,
and demonstrated that EDB does not persist and will slowly dissipate over
time in diquat dibromide.
EPA issued a Registration Standard for diquat dibromide in June 1986
(NTIS #PB87-105490). A 1991 Data Call-In required additional toxicology,
ecological effects, environmental fate, and residue chemistry data. Currently,
43 products containing the active ingredient diquat dibromide are registered
and marketed under the trade name Diquat.
Toxicity
In studies using laboratory animals, diquat dibromide has been shown
generally to be of moderate toxicity. It can cause slight to severe eye
irritation and has been placed in Toxicity Category II (the second highest of
four categories) for acute dermal and eye irritation effects. It is slightly
acutely toxic by the oral and inhalation routes and has been placed in Toxicity
Category III for these effects. Diquat dibromide causes slight dermal
irritation and has been placed in Toxicity Category IV for this effect. It is not
a skin sensitizer.
A supplemental subchronic dermal toxicity study using rabbits indicated
that diquat dibromide is toxic via repeated dermal exposure. A second dermal
study using rats resulted in high mortality, decreased food consumption and
weight gain, congestion in the lungs, liver and kidneys, and dermal irritation
at the application site. An inhalation study using rats resulted in increases in
lung weight, lung/body weight and lung/brain weight, lung lesions, and
mottling and reddening of the lungs in females; however, all effects except
the latter were reversible. A second inhalation study using rats showed no
effects on any of the parameters examined.
A chronic feeding/carcinogenicity study using rats resulted in eye
effects including lens opacity and severe cataracts. A feeding study using
beagle dogs showed some incidence of cataracts, and decreased adrenal and
epididymide weights in males.
Another chronic feeding/cancer study using rats resulted in evidence of
bone tumors. The Agency's Health Effects Division Reference Dose/Peer
Review Committee evaluated the carcinogenic potential of diquat dibromide
in March 1994 and classified it as a Group E carcinogen —a chemical for
which there is evidence of non-carcinogenicity for humans—based on a lack of
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evidence in studies with two species, rat and mouse. In a study using mice,
diquat was not carcinogenic.
A supplemental developmental toxicity study using rats resulted in
maternal toxicity and developmental toxicity only at the highest dose level.
Another more recent study using rats resulted in effects at high dose levels
including decreases in fetal and litter weights, kidney effects, and incomplete
development of certain bones. In a supplementary study using rabbits,
decreased body weight gain in the high dose group was the only maternal
toxicity observed. A recent study using rabbits resulted in developmental
effects only in the high dose group, including liver effects and poor
ossification. A study using mice resulted in developmental toxicity only in
the high dose group, including decreased fetal body weight and increased
skeletal alterations.
A reproductive toxicity study using rats resulted in effects at the highest
dose level including decreased numbers of live pups per litter and decreased
body weight gain. Diquat dibromide was negative in four mutagenicity
studies and positive in two other studies. Metabolism studies indicate that it is
poorly absorbed from the gastrointestinal tract and primarily excreted in
urine. An acute neurotoxicity study using rats resulted in symptoms that may
not be due to direct neurotoxicity. In a subchronic neurotoxicity study, toxic
signs observed only in the high dose
group included cataracts and decreased body weight gain and food utilization.
Dietary Exposure
People may be exposed to residues of diquat dibromide through the diet.
Tolerances or maximum residue limits have been established for a variety of
crop and animal commodities (please see 40 CFR 180.226 (a) and (b)). A
food additive tolerance is established for residues in potable water (40 CFR
185.2500 (a) and (b)). Food and feed additive tolerances also are established
for residues in processed potatoes (including potato chips) (40 CFR 185.2500
(c)) and processed potato waste (40 CFR 186.2600).
The registrant has proposed revised tolerances for many commodities,
some at EPA's recommendation. A tolerance for sugarcane must be revoked
since this use is no longer registered. A tolerance for potable water also will
be revoked since it has been replaced with a Maximum Contaminant Level
Goal (MCLG) under the Safe Drinking Water Act. The U.S. tolerances for
eggs, poultry, meat, and offal may be raised to achieve harmonization with
Codex Maximum Residue Levels (MRLs). With these changes, diquat
dibromide tolerances are considered appropriate.
EPA has assessed the dietary risk posed by diquat dibromide
considering both published and proposed tolerances. The Anticipated Residue
Concentration (ARC) for the overall U.S. population and 22 subgroups
represents 31% of the Reference Dose (RfD), or amount believed not to cause
adverse effects if consumed daily over a 70-year lifetime. The most highly
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exposed subgroup, non-nursing infants less than one year old, has an ARC
which represents 49% of the RfD. Diquat dibromide's chronic dietary risk is
therefore considered minimal.
Occupational and Residential Exposure
Based on current use patterns, workers (mixers, loaders, applicators, and
other handlers) may be exposed to diquat dibromide during and after
application in agricultural and other settings. During large-scale applications,
the highest potential exposure and risks are to mixers and loaders using open
systems to support aerial applications (their dermal Margin of Exposure
(MOE) is 71, less than the 100-fold margin considered acceptable). Using
closed systems, their dermal MOE is 400. EPA therefore is requiring closed
mixing/loading of diquat dibromide for aerial applications.
For applicators participating in large-scale applications and for all
workers (including homeowners) participating in small-scale applications,
MOEs are greater than 100.
Post-application exposure to diquat dibromide residues on treated
foliage is a concern. For uses within the scope of the Worker Protection
Standard for Agricultural Pesticides (WPS), EPA is requiring a longer interim
Restricted Entry Interval (REI) and more stringent personal protective
equipment (PPE) than usual, to reduce potential exposure and risk (see Risk
Mitigation below).
For uses outside the scope of the WPS, post-application exposure risks
also are posed. For example, golf course workers who have substantial
physical contact with treated turf have a MOE of 13, 24 hours after
application. At four days post-application, the MOE rises to 105. Therefore,
a four-day reentry interval is being recommended for these workers. To
reduce the potential for post-application residential exposure, spot treatments
will be acceptable but broadcast treatments will be prohibited. Swimmers
may be exposed to diquat dibromide residues in treated lakes and ponds,
however their estimated MOE of 1,250 is acceptable.
Human Risk Assessment
Diquat dibromide is of moderate acute toxicity causing acute dermal
toxicity and primary eye irritation (Toxicity Category II). It is classified as a
Group E carcinogen, indicating that it poses no known cancer risk for
humans. Diquat dibromide causes developmental and reproductive toxicity at
the highest dose levels tested. Human incident data from California and other
sources were considered in evaluating diquat dibromide's risks.
Although people may be exposed to residues of diquat dibromide
through their diets, the chronic dietary risk from such exposure is minimal.
EPA is concerned about worker exposure to diquat dibromide during aerial
spray operations, and is requiring use of closed systems to mitigate potential
risks. The Agency also is concerned about post-application/reentry exposure
for uses both within and outside the scope of the WPS. EPA therefore is
imposing stringent reentry restrictions and protective clothing requirements
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for commercial uses, and is limiting residential use to spot treatments with
label directions warning these users not to touch treated plants until sprays
have dried.
Environmental
Assessment
Environmental Fate
Diquat dibromide's primary route of environmental dissipation is strong
adsorption to soil particles. Diquat does not hydrolyse or photodegrade and is
resistant to microbial degradation under aerobic and anaerobic conditions. No
major degradates have been isolated. When used as an aquatic herbicide,
diquat dibromide is removed from the water column by adsorption to soil
sediments, aquatic vegetation, and organic matter. Adsorbed diquat
dibromide is persistent and immobile, and is not expected to be a ground-
water contaminant.
Ecological Effects
Diquat dibromide is moderately toxic to birds in acute studies, and is
slightly to moderately toxic on a subacute dietary basis. It is practically non-
toxic to bees. In acute studies, diquat dibromide is slightly to moderately
toxic to both cold and warm water fish. In fish early life stage studies, it
ranges in toxicity from slightly to moderately toxic. It is slightly to highly
toxic to both aquatic invertebrates and estuarine species. Additional studies
are required to determine diquat dibromide's toxicity to nontarget aquatic and
terrestrial plants.
Ecological Effects Risk Assessment
High acute risk to birds is not expected from use of diquat dibromide.
However, the turf use exceeds EPA's level of concern for restricted use, and
for endangered bird species feeding on short grass. Regarding chronic effects,
birds feeding on diquat dibromide-contaminated food items may experience
reproductive problems.
Diquat dibromide will pose only a low overall risk to mammals.
Effects, if they occur, should not result in significant ecological damage.
However, the Agency is only moderately certain that nonendangered
mammals are not at acute risk from diquat dibromide, which exceeds the
restricted use level of concern for all uses except cantaloupes. The level of
concern for endangered species is exceeded for all use patterns. Chronic risks
to mammals are believed to be low.
Diquat dibromide may pose acute or chronic risk to aquatic organisms,
but the probability that exposure will occur is relatively low. It is therefore
expected to pose only a minimal risk to aquatic organisms from exposure to
runoff. Diquat dibromide does not cause adverse effects to freshwater fish.
Freshwater invertebrates are not likely to be adversely affected by its use in
the short term, but their reproductive success may be adversely effected.
Drift from aerial spraying of diquat dibromide is likely to result in
adverse effects to plants. The possibility of risk to non-target aquatic and
terrestrial plants from aerial application from all sites is relatively high.
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Risk Mitigation
Diquat dibromide poses only minimal risk to non-target insects.
However, levels of concern have been exceeded for endangered species of
mammals and birds from all terrestrial use sites.
EPA is requiring the following risk mitigation measures for diquat
dibromide:
Aquatic Risk Mitigation - To protect aquatic organisms, EPA is
requiring labeling that limits application of diquat dibromide to one-third or
one-half of the dense weed areas in a water body, and prohibits subsequent
applications for two weeks. The untreated part of the water body will act as a
refuge for aquatic organisms, and the two-week waiting period allows time
for oxygen levels to recover before further applications are made.
Spray Drift Risk Mitigation - Since the possibility of risk to non-
target aquatic and terrestrial plants from aerial application is high, EPA is
requiring that a Spray Drift Advisory which recommends best management
practices to minimize spray drift appear on labels of products that can be
applied aerially.
Application and Post-Application Risk Mitigation - To protect
handlers during agricultural use, EPA is requiring closed mixing/loading of
diquat dibromide liquid formulations for aerial applications, in keeping with
WPS provisions. EPA also is requiring a 7-day interim Restricted Entry
Interval (REI) for all uses within the scope of the WPS, as well as more
stringent Personal Protective Equipment (PPE) including protective eyewear
for early-entry workers.
For occupational uses that are not within the scope of the WPS
(primarily the turf use), EPA is establishing a 4-day entry restriction for
workers.
EPA is retaining the 24-hour swimming prohibition on diquat
dibromide products with aquatic uses. Swimmers are prohibited from
swimming in treated water for 24 hours.
To protect home users, EPA is establishing an entry restriction for spot
treatment applications (label directions warning people and pets not to touch
treated plants until sprays have dried), and is prohibiting broadcast
applications at residential sites.
Additional Data
Required
EPA is requiring the following additional generic data for diquat
dibromide to confirm its regulatory assessments and conclusions:
° Enforcement method for plant and animal commodities (independent
laboratory validation);
° Product chemistry.
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Product Labeling
Changes Required
Although not part of the target data base, the following studies also are
required:
o Terrestrial plant studies; vegetative vigor.
The Agency is requiring product-specific data including product
chemistry and acute toxicity studies, revised Confidential Statements of
Formula (CSFs), and revised labeling for reregi strati on.
All diquat dibromide end-use products must comply with EPA's current
pesticide product labeling requirements, and with the additional requirements
summarized below. Please see the RED document for a complete list of
labeling requirements.
Personal Protective Equipment (PPE) Requirements
For Occupational Use
The minimum, baseline PPE for all diquat dibromide WPS and
nonWPS occupational end-use products is:
"Applicators and other handlers must wear:
—Coveralls over long-sleeved shirt and long pants;
—Chemical-resistant gloves;
—Chemical-resistant footwear plus socks;
—Chemical-resistant headgear for overhead exposure;
—Chemical-resistant apron when cleaning equipment, mixing, or
loading;
—A dust/mist filtering respirator (MSHA/NIOSH approval number
prefix TC-21C).
The PPE that would normally be established based on the toxicity of the end-
use product must be compared to the minimum PPE specified above, and the
more protective PPE must be placed on the product labeling.
Entry Restrictions
For Occupational Use
A 7-day restricted entry interval (REI) is required for uses within the
scope of the WPS. The PPE required for early entry is:
—Coveralls over long-sleeved shirt and long pants;
—Chemical-resistant gloves;
—Chemical-resistant footwear plus socks;
—Chemical-resistant headgear for overhead exposures;
—Protective eyewear.
For products with non-WPS sites such as golf courses, parks, etc., the
following statement is required:
"For 4 days following applications to non-crop areas (other than aquatic
or residential sites), do not allow employees to have contact with the
treated plants, except for contact with their footwear."
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For Home Use
For spot treatments to residential sites, the following statement is
required:
"Do not allow people or pets to touch treated plants until the sprays
have dried."
Other Labeling Requirements
For Occupational Use
• Application Restrictions:
"Do not apply this product in a way that will contact workers or other
persons, either directly or through drift. Only protected handlers may
be in the area during application."
• Engineering Controls:
"Mixers and loaders supporting aerial applications are required to use
closed systems. The closed system must be used in a manner that meets
the requirements listed in the Worker Protection Standard (WPS) for
Agricultural Pesticides (40 CFR 170.240(d)(4)). When using the closed
system, the mixers' and loaders' PPE requirements may be reduced or
modified as specified in the WPS."
"When handlers use closed systems, enclosed cabs, or aircraft in a
manner that meets the requirements listed in the Worker Protection
Standard (WPS) for Agricultural Pesticides (40 CFR 170.240(d)(4-6)),
the handler PPE requirements may be reduced or modified as specified
in the WPS."
• User Safety Requirements:
"Follow manufacturer's instructions for cleaning/ maintaining PPE. If
no such instructions exist for washables, use detergent and hot water.
Keep and wash PPE separately from other laundry."
• User Safety Recommendations:
° "Users should wash hands before eating, drinking, chewing gum,
using tobacco, or using the toilet."
o "Users should remove clothing immediately if pesticide gets inside.
Then wash thoroughly and put on clean clothing."
° "Users should remove PPE immediately after handling this product.
Wash the outside of gloves before removing. As soon as possible, wash
thoroughly and change into clean clothing."
For Home Use
• Application Restrictions:
"Do not apply this product in a way that will contact any person or pet,
either directly or through drift. Only persons applying this product may
be in the area during application."
• User Safety Recommendations:
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Regulatory
Conclusion
For More
Information
o "Clothing and protective equipment exposed to this product should be
washed in detergent and hot water. Such items should be kept and
washed separately from other laundry."
° "Users should wash hands before eating, drinking, chewing gum,
using tobacco, or using the toilet."
° "Users should remove clothing immediately if pesticide gets inside.
Then wash thoroughly and put on clean clothing."
o "Users should remove PPE immediately after handling this product.
Wash the outside of gloves before removing. As soon as possible, wash
thoroughly and change into clean clothing."
Environmental Hazard -
For products intended for terrestrial nonfood sites, use this
precautionary statement:
"This pesticide is toxic to aquatic invertebrates. Do not apply directly
to water, or to areas where surface water is present or to intertidal areas
below the mean high water mark. Do not contaminate water when
disposing of equipment washwater or rinsate."
For products intended for outdoor residential sites, use this
precautionary statement:
"This pesticide is toxic to aquatic invertebrates. Do not apply directly
to water."
Spray Drift Label Advisory
See the diquat dibromide RED document for the complete text of this
Label Advisory, which must be placed on the labeling of each product that
can be applied aerially.
The use of currently registered products containing diquat dibromide in
accordance with approved labeling will not pose unreasonable risks or adverse
effects to humans or the environment. Therefore, all uses of these products
are eligible for reregi strati on.
Diquat dibromide products will be reregistered once the required
product specific data, revised Confidential Statements of Formula, and revised
labeling are received and accepted by EPA.
EPA is requesting public comments on the Reregi strati on Eligibility
Decision (RED) document for diquat dibromide during a 60-day time period,
as announced in a Notice of Availability published in the Federal Register.
To obtain a copy of the RED document or to submit written comments, please
contact the Pesticide Docket, Public Response and Program Resources
Branch, Field Operations Division (7506C), Office of Pesticide Programs
(OPP), US EPA, Washington, DC 20460, telephone 703-305-5805.
Electronic copies of the RED and this fact sheet can be downloaded
from the Pesticide Special Review and Reregi strati on Information System at
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703-308-7224. They also are available on the Internet on EPA's gopher
server, GOPHER.EPA.GOV, or using ftp on FTP.EPA.GOV, or using WWW
(World Wide Web) on WWW.EPA.GOV.
Printed copies of the RED and fact sheet can be obtained from EPA's
National Center for Environmental Publications and Information
(EPA/NCEPI), PO Box 42419, Cincinnati, OH 45242-0419, telephone 513-
489-8190, fax 513-489-8695.
Following the comment period, the diquat dibromide RED document
also will be available from the National Technical Information Service
(NTIS), 5285 Port Royal Road, Springfield, VA 22161, telephone 703-487-
4650.
For more information about EPA's pesticide reregi strati on program, the
diquat dibromide RED, or reregi strati on of individual products containing
diquat dibromide, please contact the Special Review and Reregi strati on
Division (7508W), OPP, US EPA, Washington, DC 20460, telephone 703-
308-8000.
For information about the health effects of pesticides, or for assistance
in recognizing and managing pesticide poisoning symptoms, please contact
the National Pesticides Telecommunications Network (NPTN). Call toll-free
1-800-858-7378, between 8:00 am and 8:00 pm Eastern Standard Time,
Monday through Friday.
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