Contents
INTRODUCTION 1
I. PESTICIDE REREGISTRATION 2
A. Reregistration Process Background 2
B. Current Status of Reregistration 3
II. REREGISTRATION PROGRESS 4
A. REDs Completed This Quarter 4
B. RED Candidates for Fiscal Year 1995 12
C. Suspended Chemical Cases 12
D. Data Submitted for Reregistration 13
III. REGISTRATION PROGRESS 16
A. Registration - An Overview 16
IV. OTHER MEASURES OF PROGRESS 18
A. Minor Uses 18
B. Product Reregistration Status 21
V. SPECIAL REVIEW DECISIONS 22
VI. CALENDAR OF EVENTS (FY 1995) 24
Appendix A. Cumulative Summary of Reregistration Actions 25
Appendix B. Cumulative Summary of Registration Actions 30
Appendix C. Other Sources of Information 34
-------
-------
INTRODUCTION
The Pesticide Reregistration Progress Report is
produced by the Special Review and Reregistra-
tion Division (SRRD), Office of Pesticide Pro-
grams (OPP), U.S. Environmental Protection
Agency (EPA), to provide information on
progress towards pesticide reregistration as
mandated under the 1988 amendments to the
Federal Insecticide, Fungicide, and Rodenticide
Act (FIFRA). Progress is reported both for the
current quarter of the fiscal year ' and cumula-
tively.
This issue of the Progress Report describes the
status of reregistration through the second
quarter fiscal year 1995 (FY 95). Ninety-seven
REDs have been completed since 1991 repre-
senting 143 chemicals/active ingredients (AIs),
3,874 products and 795 tolerances. Approxi-
mately 641 products have completed the process
and have been reregistered. Please see Appendix
A for a more detailed cumulative summary.
The Pesticide Reregistration Progress Report
has added a new feature with this edition. In
order to better reflect program-wide accomplish-
ments and the efforts being made toward rein-
vention and realignment, we are including re-
ports on "new" pesticide registrations — those
pesticide AIs initially registered from November
1984 to the present. Under FIFRA '88, these
pesticides are not subject to reregistration be-
cause their supporting data bases are assumed to
be substantially complete. We include these new
AIs to illustrate EPA's progress in registering
new pesticides as well as reregistering older
ones. See Appendix B for the cumulative list. In
future editions of the Progress Report, we will
further expand our reporting on Registration
activities and milestones.
Another change is that OPP will publish this
expanded Pesticide Progress Report only twice a
year, at the close of the second quarter (April)
and year's end (October). Our move to a bi-
annual publication is intended to improve effi-
ciency and the timeliness of the Progress Report.
1 The fiscal year runs from October through September, and is divided into four quarters: the
first quarter consists of October, November, December; the second quarter consists of Janu
ary, February, March; the third quarter consists of April, May, June; and the fourth quarter
consists of July, August, September.
-------
I. PESTICIDE REREGISTRATION
A. Reregistration Process Background
EPA is required by law to reregister existing
pesticides that originally were registered years
ago when the standards for government approval
were less stringent than they are today. This
comprehensive reevaluation of pesticide safety is
critical to protecting human health and the
environment. In 1988, Congress amended the
Federal Insecticide, Fungicide, and Rodenticide
Act (FIFRA) to strengthen and accelerate EPA's
reregistration program. The nine-year reregistra-
tion scheme mandated by "FIFRA '88" applies to
each registered pesticide product containing an
active ingredient initially registered before
November 1, 1984.
In 1988, approximately 600 groups of related
pesticide active ingredients, or "cases," repre-
senting 1,150 active ingredients in 45,000 formu-
lated products, required reevaluation. As FIFRA
'88 directed, EPA divided these 600 cases into
four lists: List A, B, C and D.
List A - List A consisted of the 194 chemical
cases (or 350 individual active ingredients) for
which EPA had issued Registration Standards
prior to the effective date of FIFRA '88. Most
pesticides with food-related uses are on List A.
List B, C and D - The remaining pesticides were
divided into three lists based upon their potential
for exposure and other factors, with List B being
of highest concern and D of least. Some of the
classification criteria included potential for
residues of concern in food or drinking water,
significance of outstanding data requirements,
potential for worker exposure, Special Review or
restricted use status, and unintended adverse
effects to animals and plants.
FIFRA '88 established mandatory reregistration
timeframes and duties. The five phases of the
reregistration process are:
Phase 1: Listing of Active Ingredients - EPA
published Lists A, B, C, and D within 10 months
of FIFRA '88 and asked registrants of these
pesticides whether they intended to seek reregis-
tration.
Phase 2: Declaration of Intent and Identification
of Studies - Registrants were required to notify
EPA whether or not they intended to reregister
their products; to identify and commit to provid-
ing necessary new studies; and to pay the first
installment of the reregistration fee. During this
phase, EPA issued guidance to registrants for
preparing their Phase 2 and Phase 3 responses.
Phase 2 activities were completed in 1990.
Phase 3: Summarization of Studies - Registrants
were required to submit summaries and refor-
matted acceptable studies, "flag" studies indicat-
ing adverse effects, re-commit to satisfying all
applicable data requirements, and pay the final
installment of the reregistration fee. Phase 3
ended in October 1990.
Phase 4: EPA Review and Data Call-in's - In
Phase 4, EPA reviewed all Phase 2 and 3 submis-
sions and required registrants to meet any unful-
filled data requirements within four years. Phase
4 was completed in 1994.
Phase 5: Reregistration Decisions - In this
phase, EPA reviews all the studies that have been
submitted for a chemical case, and decides
whether or not to reregister products containing
the active ingredients in that case, A pesticide
will be considered eligible for reregistration if its
data base is substantially complete, and if it does
not cause unreasonable adverse effects to people
or the environment when it is used according to
product label directions and restrictions.
-------
B. Current Status of Reregistration
Figure 1 shows the status of supported chemi-
cal cases in Lists A, B, C, D, and all lists com-
bined, through the end of the second quarter
1995. Each column shows the total number of
supported chemical cases currently on each list.
Also shown are the numbers and percentages of
those cases that have REDs completed, and cases
that are in the category of Awaiting Data/Data in
Review. Of the total of 612 cases2 (representing
1,138 AI's) that were eligible for reregistration in
1988, 405 (representing 590 AI's) still are sup-
ported while 207 are not supported by their
registrants. A list of REDs completed appears in
Appendix A, Cumulative Summary of Reregis-
tration Actions.
Figure 1
Current Status of Reregistration - Supported Chemical Cases - Second Quarter FY 95
COMPLETED REDS AND SUPPORTED
CHEMICAL CASES
LIST
A
LIST
B
Reregistration Eligibility
Decisions (REDs)
24%
LIST
C
25%
LIST
D
ALL
LISTS
20
34
49%
97
24% A
115
76%
97 J93*! 6. I75%b 35
308 I 76%
Supported: Awaiting
Data/Data in Review
(Toall04)
(Total 81)
(Total 69)
(Total 405)
Note: These numbers change frequently as the reregistration process continues. Percentage discrepancies may
result from rounding.
2 This number was originally 611 cases, which became 612 when two active ingredients were
separated to become individual cases.
-------
II. REREGISTRATION PROGRESS
A. REDs Completed This Quarter
This section summarizes RED production
during the second quarter of fiscal year 1995,
and summarizes the information in the individual
REDs.
In reviewing pesticides for reregistration, EPA
gathers a substantially complete set of data on
each chemical case, examines related health and
environmental effects, and attempts to mitigate
effects of concern. This evaluation and risk
management process is complete when EPA is
satisfied that the pesticide(s), used in accordance
with approved labeling, will not pose unreason-
able risks to human health or the environment.
When some or all uses of a pesticide are deter-
mined to be eligible for reregistration (or when
another regulatory conclusion has been reached),
EPA issues a Reregistration Eligibility Decision
(RED), usually embodied in a RED document.
About 14 months later, once certain product-
specific data and revised labeling are submitted
and approved, EPA begins reregistering single-
active ingredient products containing the pesti-
cides included in these REDs. Products that
contain active ingredients in addition to these
will not be reregistered until all of their active
ingredients are eligible for reregistration.
FY 95 REDs Production
Figure 2 shows the number of REDs scheduled
to be completed by quarter during fiscal year
1995, and the number actually completed
through the second quarter. Seven REDs were
completed in the second quarter, covering a total
of 14 chemicals and 238 products. The target
for the fiscal year is 40 REDs. A cumulative
total of 97 REDs have been completed to date.
For further information, see Appendix A, Cumu-
lative Summary of Reregistration Actions.
Figure 2
REDs Scheduled and Completed by Quarter - FY 95
15 T
10
-G
I
5 -
10
ElUJREDs Completed (16)
-B— REDs Scheduled (40)
10
-B-
10
10
1st Quarter
2nd Quarter
3rd Quarter
4th Quarter
-------
2st Quarter RED Summaries
During the second quarter of fiscal year 1995,
EPA completed the REDs summarized below:
Aliphatic Alcohols - Aliphatic alcohols (case
4003) contains the active ingredients ethanol and
isopropanol. These chemicals are used as hard
surface treatment disinfectants, sanitizers, a
sterilant, virucides, fungicides, and mildewcides.
Ethanol also is used as a plant growth regulator
(ripener), and is used with quaternary ammonium
compounds in swimming pool v/ater systems.
Isopropanol also is used in combination with
other pesticide active ingredients to kill fleas,
ticks, and other household insects. Both ethanol
and isopropanol are well known substances and
have a wide range of human uses. All of their
pesticidal uses are eligible for reregistration.
Aliphatic alcohols are of low acute toxicity, and
no dietary exposure is expected from their use as
pesticides. Developmental or reproductive
effects are not expected to occur from the
potential dermal and inhalation exposures that
may result from registered pesticidal uses.
Significant exposure to the environment from
their use of pesticides is not anticipated. Ethanol
and isopropanol are practically non-toxic to all
species tested, and are used primarily indoors.
Exposure to terrestrial organisms would be
extremely minimal. For additional information,
please contact Leonard Ryan at 703-308-8067.
Amitraz - Amitraz or BAAM is an insecticide
and acaricide used primarily to control the pear
psylla on pear crops, and also to control white-
flies and mites on cotton and pear crops, ticks,
lice, and mange mites on beef and dairy cattle
and swine, and ticks on dogs. All uses are
eligible for reregistration provided that risk
mitigation measures outlined in the RED docu-
ment are implemented.
Amitraz is of relatively low acute toxicity but has
been demonstrated to cause cancer in mice and is
classified as a Group C "possible" human car-
cinogen. People may be exposed to residues in
pears and other foods. However, chronic expo-
sure in the diet is at a low level and is not a cause
for concern at this time.
EPA is concerned that amitraz has the potential
to cause reproductive, developmental, and
neurological toxicity risks to the general popula-
tion. Handlers applying amitraz to pear or-
chards, cotton fields, and livestock on a long-
term basis may be at risk for cancer effects. Both
handlers and reentry workers in pear orchards
and cotton fields also may be at risk for acute
neurotoxic effects. To reduce risks of cancer and
neurotoxicity to the general public and amitraz
handlers, EPA is requiring a number of risk
mitigation measures.
An amitraz degradate may pose an acute hazard
to birds since it is more acutely toxic and more
persistent in the environment than the parent.
Use of amitraz on cotton and pears may ad-
versely affect avian reproduction, aquatic inver-
tebrates, and endangered small animals.
The following risk mitigation measures com-
bined with generic worker protection labeling
should mitigate unacceptable neurotoxicity risks
to amitraz handlers:
• For the Pear Use:
Closed system mixing and loading;
Applications from within an enclosed cab;
and
Minimal (baseline) personal protective
equipment (PPE).
-------
• For Cotton Use:
Closed system mixing and loading;
Mechanical flagging; and
Minimal (baseline) PPE.
• For the Livestock Spray/Dip Use:
Minimal (baseline) PPE.
The following risk mitigation measures
combined with generic worker protection label-
ing should mitigate unacceptable neurotoxicity
and cancer risks to post-application workers:
• For the Pear Use:
Minimum of 35 days between applica-
tions; and
Restricted-entry interval of 28 days
(increased from 24 hours).
• For the Cotton Use:
Mechanical harvesting; and
Restricted-entry interval of 48 hours
(increased from 24 hours).
The following risk mitigation measures are
required to reduce exposure to birds and small
mammals:
• For the Pear Use:
Deletion of pre-bloom use; and
Limit use to two applications per season.
EPA has determined that amitraz is a valuable
tool to control pear psylla, whiteflies, and mites.
Considering the limited acreage involved in its
use on pears and cotton and the risk mitigation
measures required, amitraz1 risk potential is
reduced. For additional information, please
contact Mario Fiol at 703-308-8049.
4-ChIorophenoxyacetic Acid (4-CPA) - 4-CPA
(case 2115) is used in the food industry as a
plant growth regulator to restrict root growth
during seed germination of mung beans. 4-CPA
is applied to the water bath used to soak these
beans. Once they have soaked for several hours,
the beans are washed to remove surface residues
and then are germinated indoors for several days.
After sprouting, the hulls and roots are discarded,
and the remaining portion is packaged and sold
for human consumption. All uses of 4-CPA are
eligible for reregistration.
4-CPA generally is of low acute and
subchronic toxicity but is a severe eye irritant. It
also has been shown to be a developmental toxin
in rats. Although people may be exposed to very
low levels of 4-CPA in their diets, this exposure
does not pose risks of concern. Since both the
pesticide's toxicity and handlers' exposure levels
are low, 4-CPA also poses only minimal risks to
workers engaged in growing mung beans.
EPA waived most ecotoxicity data require-
ments for reregistration of the mung bean use of
4-CPA because this use is entirely indoors result-
ing in practically no exposure to non-target
organisms. 4-CPA, as typically used in growing
mung beans, is not likely to be released to the
environment in significant amounts in effluent.
Any exposure to fish, wildlife, or endangered
species would be regulated under the NPDES
permit program. Therefore, ecological risk is
minimal. For additional information, please
contact Tom Luminello at 703-308-8075.
Diquat Dibromide - Diquat dibromide (case
0288) is a non-selective contact herbicide,
algicide, desiccant, and defoliant. It is used to
control broadleaf and grassy weeds in non-crop
(including residential) and aquatic areas, and in
seed crops and potatoes. Its largest use is as a
desiccant on potato crops.
Diquat dibromide is of moderate acute
toxicity causing acute dermal toxicity and
primary eye irritation (Toxicity Category II). It
is classified as a Group E carcinogen indicating
that it poses no known cancer risk for humans.
-------
Diquat dibromide causes developmental and
reproductive toxicity at the highest dose levels
tested. Human incident data were considered in
evaluating diquat dibromide's risks.
Although people may be exposed to residues of
diquat dibromide through their diets, the chronic
dietary risk from such exposure is minimal. EPA
is concerned about worker exposure during
aerial spray operations, and is requiring use of
closed systems to mitigate potential risks. The
Agency also is concerned about post-application/
reentry exposure, and is imposing stringent
reentry restrictions and protective clothing
requirements for commercial uses, and limiting
residential use to spot treatments with label
directions warning users not to touch treated
plants until sprays have dried.
Birds feeding on diquat dibromide-contami-
nated food items may experience reproductive
problems. EPA is only moderately certain that
nonendangered mammals are not at acute risk
from diquat dibromide, which exceeds the
restricted use level of concern for all uses except
cantaloupes. The level of concern for endan-
gered species is exceeded for all use patterns.
Diquat dibromide is expected to pose only a
minimal risk to aquatic organisms from exposure
to runoff. Diquat dibromide does not cause
adverse effects to freshwater fish. Freshwater
invertebrates are not likely to be adversely
affected by its use in the short term, but their
reproductive success may be adversely effected.
Drift from aerial spraying is likely to result in
adverse effects to plants. The possibility of
risk to non-target aquatic and terrestrial plants
from aerial application from all sites is relatively
high.
Diquat dibromide poses only minimal risk to
non-target insects. However, levels of concern
have been exceeded for endangered species of
mammals and birds from all terrestrial use sites.
EPA is requiring the following risk mitigation
measures:
• Aquatic Risk Mitigation - To protect aquatic
organisms, EPA is requiring labeling that limits
application to one-third or one-half of the dense
weed areas in a water body, and prohibits subse-
quent applications for two weeks. The untreated
part of the water body will act as a refuge for
aquatic organisms and the two-week waiting
period allows time for oxygen levels to recover
before further applications are made.
• Spray Drift Risk Mitigation - Since the
possibility of risk to non-target aquatic and
terrestrial plants from aerial application is high,
EPA is requiring that a Spray Drift Advisory
which recommends best management practices to
minimize spray drift appear on labels of products
that can be applied aerially.
• Application and Post-Application Risk
Mitigation - To protect handlers during agricul-
tural use, EPA is requiring closed mixing/loading
of diquat dibromide liquid formulations for aerial
applications, in keeping with Worker Protection
Standard (WPS) provisions. EPA also is requir-
ing a 7-day interim Restricted Entry Interval
(REI) for all uses within the scope of the WPS,
as well as more stringent Personal Protective
Equipment (PPE) including protective eyewear
for early-entry workers.
For occupational uses that are not within the
scope of the WPS (primarily the turf use), EPA is
establishing a 4-day entry restriction for workers.
EPA is retaining the 24-hour swimming prohi-
bition on diquat dibromide products with aquatic
uses. Swimmers are prohibited from swimming
in treated water for 24 hours.
To protect home users, EPA is establishing an
entry restriction for spot treatment applications
(label directions warning people and pets not to
-------
touch treated plants until sprays have dried), and
is prohibiting broadcast applications at residen-
tial sites.
For additional information, please contact
Kylie Rothwell at 703-308-8055.
DOWICIL®CTAC - Dowicil®CTAC (case
3069) is used as a microbicide/microbistat for
secondary oil injection water-water treatment
and as a preservative for industrial adhesives and
coatings; in resin/latex/polymer emulsions;
metalworking cutting fluids; oil recovery drilling
muds/packer fluids; latex (in-can) paints; spe-
cialty industrial products; textiles/textile fibers/
cordage; and wet-end additives/industrial pro-
cessing chemicals. The case Dowicil®CTAC
contains the two active ingredients Dowicil®75
and Dowicil®150. All uses are eligible for
reregistration.
Dowicil®CTAC has no food or feed uses, so
dietary risk is not expected. The chemical
causes moderate acute dermal toxicity. To
protect applicators' skin during open pouring of
end-use products, EPA is requiring use of chemi-
cal resistant gloves. Dowacil®CTAC has the
potential to release formaldehyde under certain
conditions. However, minimal risk is expected in
residential settings. Occupational risks are low
due to the chemical's use pattern and because
OSHA monitors exposure to formaldehyde for
industrial uses. No human health risk of concern
therefore is expected.
Both Dowicil®75 and Dowicil®150 are
slightly toxic to birds, fish, aquatic invertebrates,
and terrestrial animals. The chronic level of
concern (LOG) for aquatic species is exceeded in
both typical and high exposure scenarios for
wet-end additives/industrial processing chemicals
and oil recovery drilling muds/packer fluids. The
acute LOG is exceeded in high exposure sce-
narios for all five use patterns examined. Endan-
gered aquatic species also are at risk under both
typical and high exposure scenarios. However,
Agency calculations likely overestimate the
actual concentrations which would be found in
the environment and effluent discharge levels are
governed by NPDES permits. For additional
information, please contact Ron Kendall at 703-
308-8068.
FENITROTHION - Fenitrothion is an organo-
phosphate insecticide and acaricide used for
commercial greenhouse and outdoor use on
ornamentals, including trees, to control a variety
of insects and mites. It also is marketed in two
new bait products used to control ants and
roaches in and around homes, stores, restaurants,
warehouses, and other sites. Two mosquito
control products used in other countries (but not
in the U.S.) to prevent malaria are being volun-
tarily cancelled by the registrant. No food or
feed uses are registered, however a food additive
regulation is established for residues in or on
wheat gluten imported from Australia.
The high-pressure handwand treatment of
ornamentals and two bait formulations of
fenithrothion are eligible for reregistration. The
Agency is deferring a decision on two other
application methods; low-pressure handwand and
knapsack/backpack spray equipment.
Fenitrothion is of moderate to high acute
toxicity, is a cholinesterase inhibitor, and presents
a potential acute health hazard. Fenitrothion has
been classified as non-carcinogenic to humans
("Group E"). Dietary exposure to fenitrothion
residues in wheat gluten is extremely low and
dietary risk is minimal.
There is uncertainty in the risk posed to
fenitrothion handlers, particularly mixers/loaders/
applicators. EPA is deferring a regulatory
decision for fenitrothion products applied using
low-pressure handwands and knapsack/backpack
-------
sprayers until chemical-specific worker exposure
studies, due within one year, are submitted.
Thus, for ornamentals, high pressure handwand
treatment is the only application method eligible
for reregistration at this time.
High acute risk is expected for birds consum-
ing grass and insects, and high chronic risk to
seed-, insect-, and grass-eating birds will occur,
following single as well as multiple applications
of fenitrothion at current full usage rates. Risk
quotients for mammals and estuarine/marine
organisms are exceeded. High acute risk to
freshwater invertebrates is expected from a
single application of fenitrothion. Honey bees
exposed to this pesticide may be adversely
effected. To reduce these risks, the registrant
has proposed numerous label modifications for
the three products used on ornamentals (see
below).
Endangered species levels of concern are
exceeded for acute effects to aquatic inverte-
brates and in some instances to birds and wild
mammals, as well as for chronic effects to birds
and aquatic invertebrates. Use limitations may
be required in the future when the Endangered
Species Protection Program goes into effect.
To lessen the acute toxicity risks of
fenitrothion, the following risk mitigation
measures are required:
• All fenitrothion products labeled for outdoor
use must be classified as restricted use pesti-
cides.
• Use of fenitrothion on Christmas tree planta-
tions, on shade trees other than those in nurser-
ies, and basal bark (drench) treatment are being
voluntarily deleted from product labels by the
registrant. These uses pose the greatest poten-
tial for exposure to non-target species.
• For the remaining ornamental uses, the regis-
trant has proposed significant label revisions to
reduce ecological risk, including:
• Reduce application rate to 0.3125
Ibs./acre;
• Reduce maximum number of applica-
tions to three per year;
• Increase minimum interval between
applications to one month;
• Remove broadcast application from the
label, limiting use to spot treatment only.
• Due to concerns about the high acute toxicity
of fenitrothion, EPA is establishing baseline
personal protective equipment (PPE) require-
ments for handlers of all end-use products, and is
establishing early-entry PPE requirements includ-
ing dermal protection PPE and protective
eyewear.
• Due to concerns about the post-application
exposure of agricultural workers, EPA is increas-
ing the interim Restricted Entry Interval (REI)
from 24 to 48 hours for all uses within the scope
of the WPS. This REI is further increased to 72
hours when fenitrothion products are used out-
doors in areas where the average rainfall is less
than 25 inches per year. The REI will be reas-
sessed upon receipt and review of the chemical
specific exposure data required in the RED.
For additional information, please contact
Dennis McNeilly at 703-308-8066.
PICLORAM - Reregistration case 0096 contains
picloram acid and its three derivatives,
triisopropanolamine picloram (TIPA-salt),
isooctyl/ethylhexyl picloram (IOE), and potas-
sium picloram (K-salt), referred to collectively as
"picloram". All uses of products containing
picloram acid and its derivatives are eligible for
reregistration, conditional upon implementation
of the mitigation measures specified in the RED
document.
-------
Picloram is a systemic herbicide used to con-
trol deeply rooted herbaceous weeds and woody
plants in rights-of-way, forestry, rangelands,
pastures, and small grain crops. It is applied in
the greatest amounts to pasture and rangeland.
Picloram products have no household or residen-
tial uses. All picloram products are classified as
Restricted Use pesticides based on hazard to
nontarget plants, and may be applied only by or
under the direct supervision of certified applica-
tors.
Picloram generally is of moderate to low acute
toxicity but causes inhalation toxicity (Toxicity
Category II). It is classified as a "Group E"
chemical—one showing evidence of non-carcino-
genicity for humans. However, it contains the
impurity HCB which is classified as a "B2"
probable human carcinogen. In addition, piclo-
ram IOE is structurally similar to DEHP, which
has been found to cause cancer in rodents. EPA
considered this information in assessing
picloram's risks.
People may be exposed to residues of picloram
through their diets since a number of food and
animal feed crop uses are registered. However,
dietary exposure and risk are extremely low.
Risks to picloram handlers (mixers/loaders/
applicators) are considered minimal, and worst-
case cancer risks to workers are not unaccept-
able (in the 10'5 to 10'7 range). To minimize risks
to handlers, EPA is requiring use of minimal,
baseline PPE (chemical-resistant gloves). To
minimize potential reentry exposure risks, EPA is
establishing restrictions on entry to treated areas.
The principal environmental risks of picloram
relate to contamination of surface and ground
water, and damage to nontarget terrestrial plants
including crops adjacent to areas of application
via runoff or drift. Nontarget plants adjacent to
areas of application may be exposed to concen-
trations of picloram many times the levels that
have been associated with toxic effects. In
addition, EPA has concerns related to endan-
gered terrestrial mammals and endangered
aquatic animals.
To lessen these risks, EPA is requiring the
following risk mitigation measures and pro-
grams:
Application Modifications
• EPA is lowering application rates and impos-
ing limits on the number and frequency of appli-
cations for all use patterns —
• The broadcast rate for range and
pasture use and the spot treatment rate
will be lowered.
• The forestry use rate and frequency
will be lowered.
• The rights-of-way use rate will be
lowered.
• Picloram will remain classified for Restricted
Use and may be identified as a candidate for
State Management Plans.
• EPA is requiring spray drift mitigation lan-
guage including an Aerial Drift Reduction Advi-
sory, as well as ground water, surface water, and
phytotoxicity advisory language on all picloram
product labeling.
Monitoring and Other Programs
• The registrant has committed to conducting a
state ground water monitoring/surveillance plan.
The results will determine whether additional
data are required or appropriate regulatory
action is necessary.
• The registrant has committed to provide
support to the Heritage programs in six states
10
-------
with the highest use of picloram. These pro-
grams map and monitor sensitive habitat in 48
states, to help protect endangered species.
Registrant Stewardship
• The registrant, DowElanco, has instituted a
strict product distribution system which includes
a mandatory training program for all picloram
distributors.
Endangered Species Protection Program
• EPA will address picloram's risks to endan-
gered plants, mammals, and aquatic species
through the Endangered Species Protection
Program, when it goes into effect.
For additional information, please contact
Venus Eagle at 703-308-8045.
11
-------
B. RED Candidates for Fiscal Year 1995
Table 1 shows the RED candidates for fiscal
year 1995. It is likely that for some of these
chemicals, REDs will be postponed until the next
Table 1
RED Candidates for FY 95
fiscal year. It is also possible that some new
chemicals may be added. The target for fiscal
year 1995 is a total of 40 REDs.
List A
Alachlor Copper Compounds II Diquat Dibromide** Linuron*
Amitraz** Copper Sulfate Ethephon* Metolachlor*
Asulam Coumaphos Ethion Nabam
Bromacil DCPA Fenamiphos Naled
Captan Diflubenzuron Fenitrothion** Picloram**
Chlorpropham
ListB
Bis(trichloromethyl)sulfone
Ethalfluralin*
ListC
Fosamine Ammonium* Starlicide
O-Benzyl-P-Chlorophenol Terbuthylazine*
Alkylimida Zolines Dowicil 100**
Ancymidol Fluoroacetic Acid
Bromohydroxyacetophenone (BHAP)* Methyl Nonyl Ketone
Chlorhexidine Derivatives Propamocarb
Dimethoxane
ListD
Agrobacter Radiobacter
Aliphatic Alcohols**
Benzocaine*
Prometryn
Sodium Omadine
Terbufos
Trichlorfon
Trifluralin
4-CPA and Salts**
Cytokinin
Gibberellic Acid
Polybutene*
*REDs were completed for these chemical cases during the first quarter of FY 95.
**REDs were completed for these chemical cases during the second quarter of FY 95.
C. Suspended Chemical Cases
EPA may issue a Notice of Intent to Suspend
(NOITS) a pesticide product based on a finding
that the registrant has failed to submit data under
the requirement(s) of a FIFRA section 3(c)(2)(B)
or a 4(d)(6) Data Call-In (DCI). Events that
may result in the issuance of a NOITS include
failing to provide adequate responses or data on
time during the reregistration process or the
Special Review process.
Suspension is an Agency action which affects
the legal status of a pesticide product registra-
tion. After a suspension becomes final and
effective, the pesticide registrant subject to
suspension may not legally distribute, sell, use,
offer for sale, hold for sale, ship, or deliver to
any person the product(s) subject to the suspen-
sion. The product registration, however, remains
in existence.
Suspension of the registration of each product
will become final unless, within 30 days of
receipt, one of the following actions is taken by
the registrant: 1) compliance with the Agency's
requirements is shown, 2) the registration is
withdrawn, or the use which triggered the re-
quirements is withdrawn, or 3) a hearing with
EPA is requested.
EPA's Office of Enforcement and Compliance
Assurance (OECA), formerly the Office of
Compliance Monitoring (OCM), has initiated
812 NOITS actions for non-compliance with
FIFRA resulting in 140 product suspensions
from November 1989 to March 1995. In other
cases, various outcomes resulted; for example,
suspensions did not occur because data were
submitted after the NOITS's were issued, or the
matters were settled resulting in data submission.
12
-------
D. Data Submitted for Reregistration
While EPA has formally evaluated the risks of
only 97 chemical cases or 152 active ingredients
for which REDs have been completed, the
Agency actually has obtained a substantial
amount of information on the remaining chemi-
cals.
Figure 3 shows the total number of studies
received, reviewed, and awaiting review by
discipline for List A chemicals. The studies were
submitted in response to the Registration Stan-
dards issued prior to FIFRA '88, as well as
subsequent Data Call-In Notices.
Figures 4, 5, and 6 show the total number of
studies received, reviewed, and awaiting review
so far for List B, C, and D chemicals respectively
in response to Data Call-Ins under FIFRA '88.
Figure 7 shows the cumulative totals of studies
received, reviewed, and awaiting review for all
lists by discipline and combined totals.
Figures
List A - Total Studies Received, Reviewed, and Awaiting Review as of Second Quarter FY 95
CO)
C
2,777
• Number of Studies Received
H Number of Studies Reviewed
E Number of Studies Awaiting Review
1,792
Residue
Chemistry
Environmental
Fate
Re-Entry Non-
Dietary
Tox Non-Cort*
Tox Cort*
1,461
Ecological
Effects
**TOX (CORT): Chronic Feeding, Carcinogenicity (Oncogenicity), Reproduction, and Developmental Toxicity
(Teratology).
* TOX (Non-CORT): These studies measure toxicity of pesticides in other than CORT studies.
13
-------
Figure 4
List B - Total Studies Received, Reviewed, and Awaiting Review as of Second Quarter FY 95
I
1
1
I
I
•i
3,
• Number of Studies Received
H Number of Studies Reviewed
E3 Number of Studies Awaiting Review
2,005
1,649
,086
Residue
Chemistry
Environmental
Fate
Re-Entry Non-
Dietary
Tox Non-Cort*
Tox Cort*
Ecological
Effects
Figures
List C - Total Studies Received, Reviewed, and Awaiting Review as of Second Quarter FY 95
I
I
1
'
*e
o>
I
I
• Number of Studies Received
• Number of Studies Reviewed
E3 Number of Studies Awaiting Review
1,052
129
Residue
Chemistry
Environmental
Fate
Re-Entry Non-
Dietary
Tox Non-Cort*
Tox Cort*
676
Ecological
Effects
**TOX (CORT): Chronic Feeding, Carcinogenicity (Oncogeniciry), Reproduction, and Developmental Toxicity
(Teratology).
* TOX (Non-CORT): These studies measure toxicity of pesticides in other than CORT studies.
14
-------
Figure 6
List D - Total Studies Received, Reviewed, and Awaiting Review as of Second Quarter FY 95
IP
•-S
I
•o
1
f
• Number of Studies Received
B Number of Studies Reviewed
E3 Number of Studies Awaiting Review
107
000
Residue
Chemistry
Environmental
Fate
Re-Entry Non-
Dietary
613
Tox Non-Cort
Tox Cort
309
160
Ecological
Effects
Figure 7
Lists A, B, C, D - Cumulative Studies Received, Reviewed, and Awaiting Review as of Second Quarter FY 95
ENumber of Studies Received
• Number of Studies Reviewed
EINumber of Studies Awaiting Review
20,116
12,422
4,486
Rtddut Ch.mlitry Ea
Ecoloilcil Efftcti All Dliclpll»
**TOX (CORT): Chronic Feeding, Carcinogenicity (Oncogenicity), Reproduction, and Developmental Toxicity
(Teratology).
* TOX (Non-CORT): These studies measure toxicity of pesticides in other than CORT studies.
15
-------
III. REGISTRATION PROGRESS
A. Registration - An Overview
The Federal Insecticide, Fungicide, and Roden-
ticide Act (FIFRA) requires that before any
person in any state or foreign country can sell or
distribute any pesticide in the United States, they
must obtain a registration or license from the
U. S. Environmental Protection Agency. The
term "pesticide", as defined in FIFRA section
2(u), means any substance or mixture of sub-
stances intended for preventing, destroying,
repelling, or mitigating any pest, and any sub-
stance or mixture of substances intended for use
as a plant regulator, defoliant, or desiccant. The
Registration Division in EPA's Office of Pesticide
Programs registers or licenses pesticide products
for distribution and sale under the provisions of
sections 3, 5, 18 and 24(c) of FIFRA. FIFRA
section 3 addresses the registration of pesticides;
section 5 covers experimental use permits for
pesticides; section 18 covers the exemption of
any Federal or State agency from FIFRA to sell
and distribute pesticides under emergency condi-
tions; section 24(c) allows the states to provide
additional uses of federally registered pesticides
within the states as state registrations.
The Registration Division is composed of three
product branches and one technical branch. The
product branches include the Antimicrobial
Program Branch, Fungicide-Herbicide Branch,
and Insecticide-Rodenticide Branch. The techni-
cal branch is the Registration Support Branch.
The Registration Division processes applications
submitted under FIFRA sections 3, 5, 18, and
24(c). The FIFRA section 3 registration process
starts when an application for registration of a
new chemical active ingredient pesticide product
is submitted to the Agency. Once it is received
and screened for completeness, the application is
forwarded to the appropriate product manage-
ment team for initial processing. If data accom-
pany the application and a technical review of
these data is needed, the data are sent to either
the technical branch within the Registration
Division or the Science Branches within the
Office of Pesticide Programs for review. After
all data have been reviewed and deemed accept-
able, the product management teams issue either
a conditional or an unconditional registration
notice or letter. This letter or notice is the
license which allows the sale or distribution of
the pesticide.
Under section 3, the Registration Division also
processes new use and "me-too" applications in
the same manner as new chemical active ingredi-
ent applications. The new use application is an
application for registration of a use or formula-
tion type that is not currently associated with any
registered product containing an active ingredi-
ent. New uses are defined as follows:
1. Any proposed use pattern (i.e., one that
would result in pesticide residues in food,
feed commodities) that would require the
establishment of a tolerance, an increase
in an established tolerance, or the exemp-
tion from the requirement of a tolerance,
or food additive regulation under section
408 or 409 of the Federal Food, Drug,
and Cosmetic Act.
2. Any aquatic, terrestrial, outdoor, or
forestry use pattern, if no product
16
-------
containing the active ingredient is cur-
rently registered for that use pattern.
3. Any additional use pattern that would
result in a significant increase in the level
of exposure, or a change in the route of
exposure of man or other organisms to
the active ingredient.
A "me-too" is an application for registration of
a pesticide product that is substantially similar or
identical in its uses, formulation, and active
ingredient(s) to products that are currently
registered.
Under section 5 of FIFRA, an individual may
apply for an experimental use permit (EUP) for a
pesticide. EUPs are issued under FIFRA section
5 to allow prospective registrants to generate
information or data necessary to register a
pesticide under section 3 of FIFRA. Pesticides
under experimental use permits may not be sold
or distributed other than through participants in
the approved experimental use program. They
may only be used at the application site of a
cooperator in the program, and only in accor-
dance with the terms and conditions of the EUP.
Under section 18 of FIFRA, states may apply
for specific exemptions or declare crisis exemp-
tions for emergency use of unregistered pesti-
cides or uses of pesticides. There are four types
of emergency exemptions. A specific exemp-
tion may be authorized in an emergency condi-
tion to avert a significant economic loss, or a
significant risk to endangered species, threatened
species, beneficial organisms, or the environ-
ment. A quarantine exemption may be autho-
rized in an emergency condition to control the
introduction or spread of any pest new to or not
theretofore known to be widely prevalent or
distributed within and throughout the United
States and its territories. A public exemption
may be authorized in an emergency condition to
control a pest that will cause a significant risk to
human health. A crisis exemption may be
utilized in an emergency condition when the time
from discovery of the emergency to the time
when the pesticide use is needed is insufficient to
allow for the authorization of a specific, quaran-
tine, or public health exemption.
Under section 24(c) of FIFRA, states may
issue registrations for additional uses of currently
registered pesticides if a special local need is
shown. Moreover, under this section of FIFRA,
a state is authorized to register new end-use
products or additional uses of federally regis-
tered pesticides if:
there exists a special local need for that
product use, and
• the use, if a food or feed use is covered
by an appropriate tolerance or has been
exempted from the requirement or a
tolerance, and
• registration for the same use has not
previously been denied, disapproved,
suspended, or cancelled by EPA, or
voluntarily cancelled by the registrant
because of health or environmental
concerns about an ingredient contained in
the product, unless EPA has reversed the
original action.
A list of active ingredients which have com-
pleted the registration process since 1984 ap-
pears in Appendix B.
17
-------
IV. OTHER MEASURES OF PROGRESS
A. Minor Uses
Table 2 provides information from the U.S.
Department of Agriculture, National Agricultural
Pesticide Impact Assessment Program
(NAPIAP). The Reregistration Notification
Network (RNN) provides information to inter-
ested parties on recent or impending pesticide
cancellations. The information here was first
published in the RNN, July 1994. For further
information on any of the following pesticides,
contact your NAPIAP State Liaison Representa-
tive or USDA at 301-504-8846.
Table 2
Proposed Use Cancellations or Tolerance Revocations - Second Quarter FY 95
Chemical
Products
Acephate
Triadimefon
Iprodione
Imazalil
Orthene
Bayleton
Rovral
Fungaflor
Affected Uses
EPA has proposed revocation of food additive regulations for
acephate, triadimefon, iprodione, and imazalil. Those food
additive tolerances affected are for FOOD HANDLING
ESTABLISHMENTS for acephate, milled fractions of BAR-
LEY and WHEAT (except flour) for triadimefon, dried
GINSENG and RAISINS for iprodione, and CITRUS oil for
imazalil. This action is being taken in response to the court-
ordered enforcement of the Delaney clause. The U.S. Court of
Appeals, Ninth Circuit has barred the establishment of food
additive regulations for pesticides which induce cancer, no
matter how infinitesimal the risk. EPA has determined that
acephate, triadimefon, imazalil, and iprodione all qualify as
animal carcinogens.
All Pesticides
Crop
Groupings
EPA has revised its crop groupings for pesticide tolerance
regulations. It has created new crop subgroups, expanded
existing crop groups, and revised representative crops in some
groups. EPA expects these revisions to promote greater use of
crop grouping for tolerance setting purposes and to facilitate
the availability of pesticides for minor crops. This rule became
final on 5/17/95.
All Pesticides
Summer Squash
EPA proposed to expand the interpretation of SUMMER
SQUASH to include CHAYOTE FRUIT when applying for
tolerances and exemptions of pesticide chemicals. This
proposed amendment is based, in part, on recommendations of
the Interregional Research Project No. 4 (IR-4).
Dichlorvos
DDVP
AMVAC Chemical Corporation, the sole technical registrant of
dichlorvos, is voluntarily deleting the following agricultural uses
from its technical and end-use labels. The deleted agricultural
uses of this insecticide are RANGELAND GRASSES, GREEN-
HOUSES, TOMATOES, TOBACCO, TOBACCO WARE-
HOUSES, various FOOD HANDLING ESTABLISHMENTS,
(Continued)
18
-------
Table 2, cont.
Proposed Use Cancellations or Tolerance Revocations - Second Quarter FY 95
Chemical
Products
Affected Uses
Dichlorvos
(Continuation)
DDVP
and all aerial applications. They will continue to support several
agricultural uses during reregistration. Some of the deleted uses
may be supported by other formulators. A final decision of the
deleted uses is unlikely to be made until after the PD 2/3 (pre-
liminary determination in Special Review) on this insecticide is
issued. Existing stocks of products with deleted uses may be
sold, distributed, and used until such stocks are exhausted.
Ethion
FMC Corporation, the basic registrant of ethion, has decided to
voluntarily delete all uses except those on citrus from their labels
and those of their reformulators. The final ethion uses (except
on citrus) produced by other registrants of reformulated products
are now being deleted. The final uses of ethion on BEANS,
EGGPLANT, PEANUTS, PEPPERS, PIMENTOS, PLUMS,
STRAWBERRIES, and TOMATOES will be deleted on 5/15/95.
The final uses of ethion on ARBORVITAE, ASH, BIRCH,
CATALPA, DOGWOOD, OAK, POPLAR, PRIVET,
TULIPTREE, and WILLOW will be deleted on 4/24/95. Other
uses of ethion are expected to be lost in the near future. FMC
Corporation has indicated that it will consider maintaining these
registrations if someone else is willing to develop the required
data. Dealers and users may distribute, sell, and use existing
stocks of ethion labeled with the deleted uses until such stocks
are depleted.
Ethoxyquin
Wrap Pack plans to voluntarily cancel their product, Apple
Wrap, which is the final use of ethoxyquin on APPLES. The
final cancellation of this product will occur, unless withdrawn,
on 04/24/95. Ethoxyquin, a fungicide, continues to be registered
on PEARS. Existing stocks of cancelled products already in the
hands of dealers and users may be distributed, sold, or used
legally until they are exhausted.
Methomyl
Lannate
DuPont Agricultural Products has requested the deletion of all
fly bait uses from their methomyl technical label due to worker
exposure concerns. The proposed deletions cover indoor fly bait
uses on AGRICULTURAL PREMISES including ANIMAL
UNITS, FARM BUILDINGS, POULTRY HOUSES, FOOD
PROCESSING PLANTS, and GARBAGE AREAS. Unless
withdrawn by DuPont, these deletions will become final on 5/5/
95. DuPont methomyl technical is formulated by other regis-
trants into fly baits. Those product registrations are still active,
available, may be used, and will be produced as long as technical
products labeled with fly bait uses are in stock.
19
-------
Table 2, cont
Proposed Use Cancellations or Tolerance Revocations - Second Quarter FY 95
Chemical
Mevinphos
Oryzalin
Propargite
Products
Phosdrin
Surflan
Comite,
Omite
Affected Uses
EPA has extended the time frame for the sale and use of
existing stocks of mevinphos from 2/28/95 to 11/30/95.
Products in the hands of dealers and distributors are to be
relabeled to provide additional worker protections. The
mandatory relabeling will also prohibit use in greenhouses and
on grapes. All mevinphos products in the channels-of-trade,
including those in the hands of growers, will be subject to
recall. In addition, Amvac's and its supplemental registered
products will be eligible for reimbursement.
EPA has proposed the revocation of tolerances on the residues
of oryzalin on COTTONSEED, BARLEY GRAIN, WHEAT
GRAIN, SUCCULENT PEAS, POTATOES, and SOYBEANS.
Registered products containing this herbicide for these sites
were cancelled in October of 1989. Because EPA believes
sufficient time has elapsed for residues to dissipate and are
unaware of any of these uses on imported commodities, we
will not recommend action levels to replace the tolerances of
these proposed revocations. Tolerances remain for oryzalin at
0.05 ppm of ALMOND HULLS, AVOCADOS, CITRUS
FRUITS, FIGS, KIWIFRUITS, NUTS, OLIVES, PISTA-
CHIOS, POME FRUITS, POMEGRANATES, SMALL
FRUITS, and STONE FRUITS.
EPA has received a petition from Uniroyal Chemical Co. to
revoke the section 409 feed additive regulation established for
propargite on DRIED APPLE POMACE. Uniroyal requested
the revocation because they felt it is no longer necessary (EPA
has determined that dried apple pomace is not a significant
feed item). EPA issued a proposed rule to revoke the section
409 food tolerances for propargite because it had determined
that propargite induces cancer in animals. If this petition is
granted, propargite in dried apple pomace will be removed
from the list of pesticides that violate the Delaney clause.
20
-------
B. Product Reregistration Status
Figure 8 shows the status of products subject to
Reregistration Eligibility Decisions (REDs)
issued to date. Overall a total of 614 products
have been reregistered, 994 have been voluntarily
cancelled, 357 have been suspended, and 1,280
are pending. "Current Decisions" covers those
products for which EPA should have made a
decision to reregister as of October 3, 1994 3.
In this category, 614 products have been reregis-
tered, 17 registrations have been amended, 994
products have been voluntarily cancelled, and
357 product registrations have been suspended,
for a total of 2,009 products. "Future Decisions"
includes the 1,280 products for which the regis-
trants response or the Agency's product reregis-
tration decision is not yet due.
Figure 8
Product Reregistration Status of 3,289 Products for 73 REDs* as of April 6,1995
FUTURE DECISIONS
PENDING REGISTRANT RESPONSE OR
EPA DECISION (1280)
CURRENT DECISIONS
REREGISTERED (641)
CANCELLED (994)
SUSPENDED (357)
* As of 4/6/95, EPA has issued product specific data call-in's for 73 REDs
covering/including 3,289 products.
3 According to FIFRA, the Agency should reach a reregistration decision on each product 14
months after issuance of a RED, provided that the registrant(s) submit(s) acceptable data on
time.
21
-------
V. SPECIAL REVIEW DECISIONS
This section summarizes the significant regula-
tory decisions made on chemicals in the Special
Review process during the second quarter, fiscal
year 1995. The formal Special Review process
for chemicals which have met or exceeded risk
criteria of unreasonable adverse effects is set
forth in 40 CFR Part 154.
Special Review decisions represent major EPA
actions which may ultimately cancel, deny, or
reclassify the registration of pesticide products,
because uses of the products may cause unrea-
sonable adverse effects on human health or the
environment. In addition, Special Review
decisions may establish policy or guidelines on
which other environmental decisions relating to
pesticide registrations are based.
Figure 9, Special Review Decisions Scheduled
and Completed, shows that OPP completed one
special review decision the second quarter of FY
95. The target for FY 95 is a total often special
review decisions. For further information on
Special Review chemicals, please call (703)
308-8010.
Figure 9
Special Review Decisions Scheduled and Completed - FY 95
5 T
4 --
2 --
1 --
HH Special Reviews Completed —•— Special Review Decisions Scheduled
3
-B
1st Quarter
2nd Quarter
3rd Quarter
4th Quarter
2nd Quarter Special Review Decision Summaries
Granular Carbofuran - On March 1, 1995, warranted extending the use on corn or sorghum
EPA published a Notice of Final Decision to On rice however, the Agency determined that a
deny reinstatement of the corn and sorghum uses iimited extension of carboruran use was neces-
and to grant a conditional 2-year extension of the Sary due to a lack of suitable alternative controls
phase-out period for use on rice. The Agency A number of limitations and conditions were
found no justification in comments received that imposed on the extension of the use on rice
22
-------
including restrictions aimed at protecting endan- use on home lawns. The Outdoor Residential
gered species that may be found in rice growing Exposure DCI requires registrants to submit
areas. The Agency expects that some special exposure data for persons commercially mixing,
local need applications will be received for loading and applying pesticides to residential
additional use on sorghum; they will be evaluated grass, lawn and turf sites, and exposure data for
individually and granted on a case-by-case basis. non-professionals who may reenter such areas
after treatment. An Outdoor Residential Task
Outdoor Residential Exposure Data Call-in Force has been organized to develop part of the
Notice - On March 10, 1995, the Agency issued data requirements. The Agency has encouraged
a Data Call-In Notice to the technical registrants individual registrants to join the Task Force.
of 114 separate active ingredients registered for
23
-------
VI. CALENDAR OF EVENTS (FY 1995)
3nd Quarter FY 95
4rd Quarter FY 95
10 REDs are scheduled to be
completed.
10 REDs are scheduled to be
completed.
3 Special review decisions are
scheduled to be completed.
3 Special review decisions are
scheduled to be completed.
Final report from Spray Drift
Task Force is due.
24
-------
Appendix A. Cumulative Summary of Reregistration Actions
The following is a cumulative summary of the
reregistration actions completed to date. OPP
has completed REDs and summary fact sheets
for each of the pesticides (cases) listed below.
How to Obtain REDs and RED Fact Sheets:
Copies of the REDs and the fact sheets may be
obtained during the public comment period from
the Pesticide Docket, Public Response and
Program Resources Branch, Field Operations
Division (7506C), Office of Pesticide Programs,
U.S. Environmental Protection Agency, Wash-
ington, DC 20460 Tel: (703)305-5805.
Electronic copies of all RED fact sheets and of
REDs issued since June 1994 can be downloaded
from the Pesticide Special Review and Reregis-
CUMULATIVE RED TOTALS
Total REDs = 97
Total Chemicals/ATs Covered = 143
Total Products Covered = 3,874
Total Tolerances Reassessed = 795
tration Information System at 703-308-7224.
They are also available on the Internet on EPA's
gopher server, GOPHER.EPA.GOV, or using
FTP on FTP.EPA.GOV., or using WWW (World
Wide Web) on WWW.EPA.GOV.
RED documents issued since April 1994 are
available free of charge while supplies last from
the National Center for Environmental Publica-
tions and Information (NCEPI), P.O. Box 42419,
Cincinnati, OH 45242-0419, Tel: (513) 489-
8190, Fax: (513)489-8695.
After the comment period, RED documents are
available from the National Technical Service
(NTIS), Attention: Order Desk, 5285 Port
Royal Rd., Springfield, VA 22161, Tel: (703)
487-4650.
DATA CALL-IN SUMMARY
Fiscal Year Number of DCIs Issued
FY 1990 27
FY 1991 159
FY 1992 97
FY 1993 93
FY 1994 77
FY 1995 1
Total 454
25
-------
FY 91 REDs Summary
RED Case Name List
1. Carbon and Carbon Dioxide D
2. Dried Blood D
3. Fosetyl-Al (Aliette) A
4. Heliothis zea (NPV) A
5. Methoprene A
6. Potassium Bromide A
7. Propionic Acid D
8. Silicon Dioxide/Silica Gel D
9. Sodium and Calcium Hypochlorites A
10. Sodium and Potassium Nitrates D
11. Sodium Diacetate D
12. Sulfur A
13. Warfarin A
Totals
Date
Signed
9/91
9/91
12/90
12/90
3/91
6/91
9/91
9/91
9/91
9/91
9/91
3/91
6/91
# Chemicals/ AIs
Covered
2
1
1
1
1
1
1
2
2
2
1
1
2
# Products*
Covered
9
3
2
1
63
2
14
75
770
6
2
332
76
Total
Tolerances
0
0
24
0
23
0
0
0
0
0
0
0
0
18
1,355
47
* The number of products listed reflects the number registered at the time the RED was completed. This number
is constantly changing.
26
-------
FY 92 REDs Summary
RED Case Name
14. Alkyl Amine Hydrochloride
15. Allium Sativum (Garlic)
16. Bone Oil
17. Capsaicin
18. Chlorinated Isocyanurates
19. Citric Acid
20. Ethylene
21. Heptachlor
22. Indole-3-Butyric Acid (IBA)
23. Nosema Locustae
24. Putrescent Whole Egg Solids
25. Soap Salts
26. Sodium Hydroxide
27. Streptomycin
28. Zinc Salts
FY 93 REDs Summary
RED Case Name
29. Biobor
30. Boric Acid
31.Butylate
32. Cedarwood Oil
33. Daminozide
34. Eugenol***
35. Glyphosate
36. Inorganic Halides
37. Iron Salts
38. Menthol
39. OBPA
40. Oxalic Acid
41. Oxytetracycline
42. PEP(phenylethyl Propionate)***
43. Silver
44. Sodium Lauryl Sulfate
45. Sulfuryl Fluoride
46. Thymol
47. Tris(hydroxymethyl)nitromethane
List
C
D
C
D
A
D
C
A
B
D
D
D
D
A
D
Totals
List
C
A
A
C
A
D
A
D
D
D
A
D
A
C
D
D
A
C
ne c
Date
Signed
8/92
6/92
**
6/92
9/92
6/92
9/92
3/92
8/92
9/92
6/92
9/92
9/92
9/92
8/92
Date
Signed
6/93
9/93
9/93
9/93
9/93
9/93
9/93
9/93
3/93
9/93
6/93
12/92
3/93
9/93
7/93
9/93
9/93
9/93
9/93
# Chemicals/ AIs
Covered
1
1
1
1
5
1
1
1
1
1
1
2
1
2
2
22
# Chemicals/ AIs
Covered
2
7
1
1
1
1
2
2
3
1
1
1
3
1
1
1
1
1
1
# Products*
Covered
3
4
2
8
741
3
8
2
31
6
6
25
9
26
7
881
# Products*
Covered
12
189
14
5
4
5
56
35
5
1
15
4
7
5
65
2
1
5
9
Total
Tolerances
0
0
N/A
0
0
0
0
0
0
0
1
0
0
14
0
15
Total
Tolerances
0
1
3
0
0
1
126
0
0
1
0
0
2
0
0
1
0
0
0
Totals
32
439
135
* The number of products listed reflects the number registered at the time the RED was completed. This number is
constantly changing.
** Voluntarily cancelled.
*** Exempted from regulation as a pesticide active ingredient under Section 25(b) of FIFRA.
27
-------
FY 94 REDs Summary
RED Case Name
48. Barium Metaborate
49. Bromine
50. Lithium Hypochlorite
51. Mineral Acids
52. Peroxy Compounds
53. Vegetable and Flower Oils
54. 2-[(Hydroxymethyl) Amino]
Ethanol or Ethanolamine
55. Hexadecadienol Acetates
56. Methiocarb
57. Periplanone B
58. Pronamide
59. Tebuthiuron
60. Maleic Hydrazide
61. N6-Benzyladenine
62. Bentazon
63. Chlorine
64. Chloromxylenol
65. Cosan 145 or Nuosept 145
66. Cresol
67. DBNPA
68. DCDIC
69. Difenzoquat
70. Fenbutatin-Oxide or Vendex
71. Hexazinone
72. Limonene
73. Mercaptobenzothiazole
74. Metalaxyl
75. Mevinphos**
76. Muscalure a(z)-a-Tricosene
77. OilofCitronella***
78. Oryzalin
79. Piperalin
80. Sodium Cyanide
Sl.Xylenol
List
A
D
C
D
D
D
C
D
A
B
A
A
A
B
A
D
C
C
D
C
C
A
A
A
C
B
A
A
D
C
A
C
C
D
Date
Signed
12/93
12/93
12/93
12/93
12/93
12/93
3/94
3/94
3/94
3/94
3/94
3/94
6/94
6/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
9/94
# Chemicals/ AIs
Covered
1
1
1
4
3
6****
2
2
1
1
1
1
2
1
2
1
1
1
1
1
1
1
1
# Products*
Covered
3
4
40
212
23
32
3
18
22
1
18
12
26
2
14
72
7
2
1
46
80
2
10
20
15
5
81
0
11
17
38
1
7
1
Total
Tolerances
0
1
0
0
0
0
0
0
0
0
46
15
4
0
45
0
0
0
0
0
0
22
44
11
0
0
95
0
0
0
20
0
0
0
Totals
48
846
303
* The number of products listed reflects the number registered at the time the RED was completed. This
number is constantly changing.
** Voluntarily cancelled.
*** Exempted from regulation as a pesticide active ingredient under Section 25(b) of FIFRA.
**** One A.I., "essential oils" will become 24 A.I.s after the RED is issued; many of these will eventually be
declared inert ingredients.
28
-------
FY 95 REDs Summary
RED Case Name
82. Benzocaine***
83. Bromohydroxyacetophenone (BHAP)
84. Ethalfluralin
85. Ethephon
86. Fosamine Ammonium
87. Linuron
88. Metolachlor
89. Polybutene
90. Terbuthylazine
91. Aliphatic Alcohols
92. Amitraz
93. 4 CPA & Salts
94. Diquat Dibromide
95. Dowicil 100
96. Fenitrothion
97. Picloram
List
D
) c
B
A
B
A
A
D
B
D
A
B
A
C
A
A
Date
Signed
12/94
12/94
12/94
12/94
12/94
12/94
12/94
12/94
12/94
3/95
3/95
3/95
3/95
3/95
3/95
3/95
# Chemicals/AIs
Covered
1
1
1
1
1
1
1
1
1
2
1
1
1
1
1
7
# Products*
Covered
1
3
6
20
1
27
47
6
4
140
8
2
77
2
8
1
Total
Tolerances
0
0
26
30
0
45
71
0
0
0
27
2
45
0
1
48
Totals
23
353
295
* The number of products listed reflects the number registered at the time the RED was completed. This
number is constantly changing.
*** Exempted from regulation as a pesticide active ingredient under Section 25(b) of FIFRA.
29
-------
Appendix B: Cumulative Summary of New Registrations Actions
The following is a cumulative summary of
"new" pesticide active ingredients initially
registered since November 1984. Under
1984 Registration Summary
Chemical Name
1. Arosurf
2. Bromo-nitropropane
3. Cholecalciferol
4. Cypermethrin
5. Fenarimol
6. Hydantoin
7. Hydroprene
8. Pirimiphos-Methyl
9. Triacontanol
FIFRA '88, such pesticides are not subject to
reregistration since their data bases are
substantially complete.
1985 Registration Summary
Chemical Name
10. Azadirachtin, Neem
11. Bifenthrin
12. Chlorpyrifos-Methyl
13. Cyromazine
14. Dodecandienoic Acid
15. Fenoxycarb
16. Linalool
17. Paclobutrazol
18. Potassium Cresylate
19. Propanoic Acid
20. Tralomethrin
1986 Registration Summary
1987 Registration Summary
Chemical Name
Chemical Name
21. (7S)-Hydroprene
22. Abamectin
23. Aldoxycarb
24. Chitosan
25. Chlorimuron-Ethyl
26. Dimethazone
27. Esfenvalerate
28. Fenridazon-Potassium
29. Fluridone
30. Imazaquin
31. Isomate-M
32. Metsulfuron-Methyl
33. Thifensulfuron-Methyl Pinnacle
34. Tridiphane
35. Bromine Chloride
36. Busan42
37. Clopyralid
38. Cyfluthrin
39. DMDH Hydantoin, MDM
40. Farnesol, Nerolidol
41. Fenoxaprop-Ethyl
42. Fomesafen
43. Imazapyr
44. Isazophos-methyl
45. Lactofen
46. Liquid Nitrogen
47. Mint Herbs, Rosemary Herbs, Tyme Herbs, Clove
48. S-Kinoprene
49. UreaSulfate
30
-------
1988 Registration Summary
1989 Registration Summary
Chemical Name
Chemical Name
50. Bacillus Thuringiensis tenebrionis
51. Bacillus Thuringiensis
52. Bromoxynil
53. Ground Sesame Stalks
54. Imazethabenz
55. Lactic Acid
56. Lambda-Cyhalothrin
57. Potassium Salts of Fatty Acids
58. Pseudomonas fluorescens
59. Quizalofop-Ethyl
60. (E)-9-Tricosene
61. B.T. Kurstaki
62. B.T. Kurstaki (EG 2348)
63. Bensulfuron Methyl Ester
64. Clofentezine
65. Clofentezine
66. Fenpropathrin
67. Flurprimidol
68. Hexythiazox
69. Imazethapyr
70. Isoxaben
71. Myclobutanil Systhane
72. Sulfluramid
73. Tefluthrin
74. Triadimenol
75. Tribenuron-Methyl
76. Trichoderma Harzianum ATTC
77. Triclopyr
1990 Registration Summary
1991 Registration Summary
Chemical Name
Chemical Name
78. 11 -Tetradeceny 1 Acetate
79. Gliocladium Virens G-21
80. Nicosulfuron (DPX-V9636)
81. Primisulfuron methyl
82. Primisulfuron-Methyl
83. Sulfosate
84. Trichoderma-Harzianum
85. 10 Dodecandien-1-ol
86. B.t. Var. Kurstaki encapsulated delta endotoxin
87. B.t. Var. Sandiego encapsulated delta endotoxin
88. B.t. EG2424
89. Bacillus Sphaericus
90. Cyphenothrin (BSI)
91. Dithiopyr
92. Fenoxaprop-Ethyl
93. Lagenidium Giganteum
94. Sodium Perborate monohydrate, acetylsalicyclid aci
95. Triflumizole
96. Uniconazole (Sumagit)
97. ZincBorate
31
-------
1992 Registration Summary
1993 Registration Summary
Chemical Name
Chemical Name
98. Bacillus Subtilis
99. Bacillus Thuringiensis Var. Aizawai Strain
100. Bacillus Thuringiensis Aizawai
101. Clethodim
102. Cyhalothrin
103. Oxadixyl
104. Phosphorous oxide
105. Prodiamine
106. Prodiamine
107. Pseudomonas Cepacia Type Wisconsin
108. Pseudomonas Syringae 742 RS
109. Pyridate
110. Quinclorac
111. Triasulfuron (Amber)
112. Zeta-Cypermethrin
113. 2-(Decylthio)Ethanamine hydrochloride
114. Alkyi Trimethyl ammonium chloride
115. Bacillus Thuringiensis Subsp
116. Cinnamomum
117. Cyproconazole
118. Dimethenamid
119. Flumetsulam
120. Flutolanil
121. Glufosinate-Ammonium
122. Hydrogen Cyanamide
123. Metarhizium Anisopliae Strain
124. Methyl2-Benzimidazolecarbamate
125. Oxazolidine
126. Puccinia cunaliculate lagerheim
127. S-Phenyl Indolbutanethiolate
128. Sodium Salts of Fatty Acids
129. Sodium Tetrathiocarbonate
130. Spodoptera Exigua NPV
131. Streptomyces Griseoviridis
132. Trinexapac-Ethyl
1994 Registration Summary
1995 Registration Summary
Chemical Name
133. Acetochlor
134. Castor Oil
135. Corn Gluten Meal
136. Deltamethrin
137. Difenuconazole
138. Duracide
139. Hexaflumuron
140. Imidacloprid
Chemical Name
141. Bacillus thuringiensis; Delta endotoxin
142. Bacillus thuringiensis
143. Beauveria bassiana
144. Beauveria bassiana
145. Candida oleophilia
146. Carbonic Acid/Monosodium Salt
147. Carbonic Acid
148. Decen-l-ol,acetate
149. Decen-1-ol
150. Diethyl Sulfide 1-Butanethiol
151. Difethialone
152. Dimethyl Napthalene Acetic Acid
153. Fenbuconazole
154. Isobardac
155. Methyl Anthranilate
156. MF-201
157. Permit
158. Prallethrin
159. Prosulmron
(Continued)
32
-------
1995 Registration Summary (Cont'd)
Chemical Name
160. Pseudomonas syringae
161. Pseudomonas syringae
162. Pyridaben
163. Resource
164. Rimsulfuron
165. Sodium 5-Nitroguaiacolate Tech
166. Tebufenozide
167. Thiazine
33
-------
Appendix C. Other Sources of Information
For documents or further information on reregistration issues related to this progress report, please
contact the following sources.
The following publications are available from:
National Center for Environmental Publications and Information (NCEPI)
P.O. Box 42419
Cincinnati, OH 45242-0419
Tel: (513)489-8190
Fax: (513)489-8695
1 Catalog of OPP Publications and Other Infor-
mation Media. March 1994
Publication Number: EPA 730-B-94-001
Lists titles and ordering information for many
types of documents published by the Office
of Pesticide Programs.
Pesticide Reregistration Pamphlet. May 1992
Publication Number: EPA 700-K92-004
Status of Pesticides in Reregistration and
Special Review (Rainbow Report! June 1994
Publication Number: EPA 738-R-94-003
Rejection Rate Analysis. Residue Chemistry
Chapter June 1992
Publication Number: EPA 738-R-92-001
Rejection Rate Analysis. Residue Chemistry
Guidance on Conducting Plant and Livestock
Metabolism Studies. July 1992
Publication Number: EPA 738-B-92-001
Rejection Rate Analysis. Residue Chemistry
Guidance for:
Storage Stability
Theoretical Concentration Factors
Raw Data Guidance. February 1993
Publication Number: EPA 737-R-93-001
Rejection Rate Analysis. Residue Chemistry/
Environmental Fate
Guidance for:
Conducting Rotational Crop Studies.
February 1993
Publication Number: EPA 738-B-93-001
Rejection Rate Analysis. Environmental Fate
Chapter. August 1993
Publication Number: EPA 738-R-93-010
• Rejection Rate Analysis. Toxicology Chapter.
July 1993
Publication Number: EPA 738-R-93-004
• Rejection Rate Analysis. Occupational and
Residential Exposure Chapter. August 1993
Publication Number: EPA 738-R-93-008
• Rejection Rate Analysis. Residue Chemistry
Guidance for:
Updated Livestock Feed Tables
Aspirated Grain Fractions
Calculating Livestock Dietary Exposure
Number and Location of Domestic Crop
Field Trials. June 1994
Publication Number: EPA 738-K-94-001
• Rejection Rate Analysis. Ecological Effects
Chapter. December 1994
Publication Number: EPA 738-R-94-035
• Pesticide Reregistration Rejection Rate Analy-
sis. Summary Chapter. February 1995
Publication Number: EPA 738-S-95-001
34
-------
Federal Register Publication of Lists A. B. C Status of Chemicals in Special Review.
andD May 1995
List A: FR 2/2/89, pages 7740-7750 For information contact: (703)308-8173
ListB: FR 5/25/89, pages 22706-22714
List C: FR 7/24/89, pages 30846-43396 National Pesticide Telecommunications
ListD: FR 10/24/89, pages 43388-43396 Network fNPTN)
For information contact: (703) 305-5805 For information about pesticide poisoning
symptoms and general information:
Tel: 1-800-858-7378; Fax: 806-743-3094
Comments
EPA welcomes your comments on this progress report and on activities related to pesticide registra-
tion and reregistration. Please address your comments to:
Attention: Ed Setren
Pesticide Reregistration Progress Report
Special Review and Reregistration Division (7508W)
United States Environmental Protection Agency
401 M Street, SW
Washington, DC 20460
For more copies of this report (Publication Number: EPA 738-R-95-020) or to be added to the
"SRRD MABELS" mailing list, please write or fax to the following address:
U.S. EPA,NCEPI
P.O. Box 42419
Cincinnati, OH 45242-0419
Telephone: (513)489-8190
Fax: (513)489-8695
35
-------
------- |