Toxic Release Inventory: List of Toxic Chemicals within Warfarin Category


&EPA
                  United Slates
                  Environmental Protection
                  Agency
                  Office of Pollution
                  Prevention and Toxics
                  Washington, DC 20460
November 1994
EPA 745-B-94-004
TOXICS RELEASE  INVENTORY
List of Toxic Chemicals within Warfarin Category
      Section 313 of EPCRA requires certain facilities manufacturing, processing, or
otherwise using listed toxic chemicals to report their environmental releases of such
chemicals annually.  Beginning with the 1991 reporting year, such facilities also must report
pollution prevention and recycling data for such chemicals, pursuant to section 6607 of the
Pollution Prevention Act, 42 U.S.C. 13106. When enacted, section 313 established an initial
list of toxic chemicals that was comprised of more than 300 chemicals and 20 chemical
categories. Section 313(d) authorizes EPA to add chemicals to or delete chemicals from the
list, and sets forth criteria for these actions.
                                  CONTENTS
      Section 1.    Introduction	2
      Section 2.    CAS Number List of Chemicals within the Warfarin Category . . 4
      Section 3.    CAS Number List of Mixtures Within the Warfarin Category  . . 5

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Section 1. Introduction
On November 30, 1993 EPA added 21 chemicals and 2 categories to the list of toxic
chemicals under section 313 of the Emergency Planning and Community Right-to-Know Act
of 1986 (EPCRA) (58 FR 63500). These additions are described at 40 CFR 372.65, and are
effective January 1, 1994 for reports due July 1995. Two chemical categories
(ethylenebisdithiocarbamic acid (EBDC), salts and esters; warfarin and salts) are included in
these additions. At the time of the addition, EPA indicated that the Agency would work with
the public and the regulated community to develop, as appropriate, interpretations and
guidance the Agency determines are necessary to facilitate accurate reporting for these
categories. This document constitutes such guidance for warfarin and salts.

EPCRA section 313 requires threshold determinations for chemical categories to be
based on the total of all chemicals in the category manufactured, processed, or otherwise
used. For example, a facility that manufactures three members of a chemical category would
count the total amount of all three chemicals manufactured towards the manufacturing
threshold for that category. When filing reports for chemical categories, the releases are
determined in the same manner as the thresholds. One report is filed for the category and all
releases are reported on this form.

The warfarin salts category is subject to the one percent de minimis concentration.
Thus, mixtures that contain members of these categories in excess of the de minimis should
be factored into threshold and release determinations.

Any compound which has a warfarin salt component is reportable. EPA is providing
the following list of CAS numbers and chemical names to aid the regulated community in
determining whether they need to report the Warfarin category. However, this list is not
exhaustive. If a facility is manufacturing, processing, or using a chemical which has a
warfarin salt component, they must report to TRI, even if this chemical does not appear on
the following list.

Who Must Report

A plant, factory, or other facility is subject to the provisions of Section 313, if it
meets all three of the following criteria:

• It conducts manufacturing operations (is include in Standard Industrial
Classification (SIC) codes 2 through 39); and

• It has 10 or more full-time employees (or the equivalent 20,000 hours per
year); and

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              It manufacturers, imports, processes, or otherwise uses any of the toxic
              chemicals listed on the EPCRA Section 313 list in amounts greater than the
              "threshold" quantities specified below.
Thresholds
       Thresholds are specified amounts of toxic chemicals used during the calendar year
that trigger reporting requirements.

       If you manufacture or import any of the listed toxic chemicals, the threshold quantity
will be:

       •      25,000 pounds per toxic chemical or category over the calendar year.

       If you process any of the listed toxic chemicals, the threshold quantity will be:

       •      25,000 pounds per toxic chemical or category over the calendar year.

       If you otherwise use any of the listed toxic chemicals (without incorporating it into
any product or producing it at the facility), the threshold quantity is:

       •      10,000 pounds per toxic chemical or category over the calendar year.

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          Section 2.  CAS Number List of Chemicals that have CAS numbers
                            within the Warfarin Category
       EPA is providing the following list of CAS numbers and chemical names to aid the
regulated community in deterniining whether they need to report for the Warfarin category.
However, this list is not exhaustive. If a facility is manufacturing, processing, or using a
chemical which has a Warfarin component, they must report to TRI, even if this chemical
does not appear on the following list.
Listing by CAS Number of Each Individual Chemical within the Warfarin and Salts Category
Collective Index Name
Warfarin
2H-l-Benzopyran-2 -one, 4-hydroxy-3-(3 -oxo-1 -phenylbutyl)-, sodium salt
Coumarin, 3-(. alpha. -acetonylbenzyl)-4-tiydroxy-, calcium salt
Coumarin, 3-(. alpha. -acetonylbenzyl)-4-hydroxy-, magnesium salt
2H-l-Benzopyran-2-one,4-hydroxy-3-(3-oxo-l -phenylbutyl)-, potassium salt
2H-l-Benzopyran-2-one,4-hydroxy-3-(3-oxo-l -phenylbutyl)-, lithium salt
2H-l-benzopyran-2-one,4-hydroxy-3-(3 oxo-1 -phenylbutyl)-, sodium salt, (S)-
2H-lBenzopyran-2 -one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, sodium salt, (R)-
2H-l-Benzopyran-2 -one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, sodium salt, (. + -.)-
2H-l-Benzopyran-2 -one, 4-hydroxy-3-(3-oxo-l -phenylbutyl)-, thallium(l + ) salt
Common Name
N/A
Warfarin sodium salt
Warfarin calcium salt
Warfarin magnesium salt
Warfarin, potassium salt
Lithium warfarin
Sodium S-warfarin
Sodium R-warfarin
(. + -.)-Warfarin sodium
Warfarin, thallium salt
CAS
Number
81-81-2
129-06-6
2084-55-1
2084-56-2
2610-86-8
2784-36-3
5543-79-3
36508-91-5*
51821-81-9*
67523-25-5*
* - Indicates the mixtures under this category

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        Section 3.  CAS Number List of Mixtures Within the Warfarin Category
       EPA is providing the following list of CAS numbers and chemical names for mixtures
which contain Warfarin and its salts. This list will aid the regulated community in
determining whether they need to report for the  Warfarin category.   However, this list is not
exhaustive.  If a facility is manufacturing, processing, or using a mixture that contains
Warfarin or a Warfarin salt component,  they must report to TRI, even if this chemical does
not appear on the following list.  Threshold calculations for the Warfarin category should
account only for the percentage of the Warfarin  component contained in the mixture.
Mixtures Containing Warfarin and its Salts
Mixture Name
Benzenesulfonamide, 4-amino-N-2-quinoxalinyl-, mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyI)-2H-l-benzopyran-2-one
1,2,3-Propanetricarboxylicacid, 2-hydroxy-, sodium salt, mixt. with acetaldehyde, 2-butanone,
N,N-dimethylmethanamine, formaldehyde, . alpha. -hydro-. omega. -hydroxypoly(oxy-l ,2-ethanediyl),
4-hydroxy-3-(3-oxo-l-phenylbutyI)-2H- l-benzopyran-2-onesodium salt and
2,2',2"-nitrilotris[ethanol]
9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol,(3.beta.,5Z,7E,22E)-, mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
lH-Indene-l,3(2H)-dione,2-(2,2-dimethyl-l-oxopropyl)-,mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-, mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
Retinol, acetate, mixt. with 4-hydroxy-2-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-onel2
Antimycin A, mixt. with 4--hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
lH-Indole-3-acetic acid, l-(4-chloroben;r.oyl)-5-methoxy-2-methyl-,mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
2-Naphthaleneaceticacid, 6-methoxy-. alpha. -methyl-, (S)-, mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
2H-l,2-Benzothiazine-3-carboxamide,4 -hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide, mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
2H,5H-l,3-Oxazino[5,6-c][l,2]benzothiazine-2,4(3H)-dione^-methyl-3-(2-pyridinyl)-,6,6-dioxide)
mixt. with 4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
Benzoic acid, 2-(acetyloxy)-, mixt. with 4-hydroxy-3-(3 oxo-1-
phenylbutyl)-2H-l-benzopyran-2-one
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-,mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
Warfarin
Component
Warfarin
81-81-2
Warfarin
Sodium Salt
129-06-6
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Mixture CAS
Number
37341-99-4
39366-36-4
54842-06-7
58934-24-0
60177-49-3
63610-50-4
64782-63-4
136153-10-1
136153-11-2
136153-09-8
136153-12-3
136153-08-7
136153-13-4

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Mixtures Containing Warfarin and its Salts
Mixture Name
3,5-Pyrazolidinedione, 1 ,2-diphenyl-4-[2-(phenylsuIfinyl)ethyl]-,mixt. with
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
2H-l-Benzopyran-2-one,4-hydroxy-3-(3-oxo-l-phenylbutyl)-,mixt. with
5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
Warfarin
Component
Warfarin
81-81-2
Warfarin
81-81-2
Mixture CAS
Number
136153-14-5
136153-15-6

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