c/EPA
           United States
           Environmental Protection
           Agency
               Office of
               Solid Waste and
               Emergency Response
Publication 9200.6-303(94-2)
EPA540/R-94/059
PB94-921101
July 1994
           Superfund
Health Effects Assessment
Summary Tables FY 1994
           Supplement Number 1

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                                        9200.6-303 (94-2)
                                        EPA/540/R-94/059
                                             PB94-921101
                                                July 1994
         HEALTH EFFECTS  ASSESSMENT

               SUMMARY TABLES


         FY-1994  Supplement No.  1
          U.S. Environmental Protection Agency
          Region 5, Library (PL-12J)
          77 West Jackson Boulevard, 12th Floor
          Chicago,  IL 60604-3590
    Office of  Research and  Development
Office  of  Emergency  and Remedial  Response
   U.S.  Environmental Protection Agency
           Washington,  DC  20460

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                           DISCLAIMER
     This  report  has  been prepared  by  the  U.S.  Environmental
Protection Agency.  The information contained herein has been taken
from final documents  prepared  by the Office of Health and Environ-
mental Assessment  for the  Office of  Solid Waste and  Emergency
Response and the Office of  Water,  Washington, DC and the Office of
Air Quality  Planning and Standards,  Research Triangle  Park,  NC.
These documents were  reviewed  in accordance with Agency policy and
approved  for publication.   Mention of trade names  or commercial
products does not constitute endorsement or recommendation for use.
                                11

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    HEALTH EFFECTS ASSESSMENT SUMMARY TABLES
            FY-1994 SUPPLEMENT NO.  1
                  Prepared by:

                 Ida C. Miller
         Oak Ridge National Laboratory
              Oak Ridge,  Tennessee
      Interagency Agreement  No.  DW89935192
                 Prepared for:

  Environmental  Criteria  and Assessment  Office
      U.S.  Environmental  Protection Agency
        26  West  Martin Luther King  Drive
             Cincinnati,  OH  45268
Eletha Brady-Roberts, Technical Project Monitor
     Patricia A. Daunt, IRIS/HEAST Liaison
         Carol Haynes, Project Officer
                 July 30, 1994

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                        TABLE OF CONTENTS

                                                             Page


INTRODUCTION   	     1

WHAT'S NEW IN THE JULY 1994 SUPPLEMENT NO. 1	9

HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)  	    1-1

REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC
TOXICITY  (OTHER THAN CARCINOGENICITY)     	  Rl-1

HEAST TABLE 3:  CARCINOGENICITY	    3-1

REFERENCES FOR HEAST TABLE 3:  CARCINOGENICITY  	  R3-1
                               ill

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                           INTRODUCTION








     This document is the July 1994 Supplement No.  1 for the March



1994 Annual Update of the Health Effects Assessment Summary Tables



(HEAST)  prepared  by EPA's  Office of  Health  and Environmental



Assessment,   Environmental   Criteria   and  Assessment   Office,



Cincinnati,  OH  for  use  at  both  Superfund  and  RCRA  sites.



Supplement No. 1 updates  the information  in the March 1994 HEAST



Annual  Update.   When  using this  document,  please refer  to the



Annual  Update.  The  supplements  were  not  produced to stand alone



and do not contain  the User's Guides or Appendix  that are available



in the  Annual  Update.   Thus, the  user  is  strongly encouraged to



reference the March 1994 HEAST for this information.



     The  HEAST  is  a   comprehensive   listing  consisting  almost



entirely of PROVISIONAL HEALTH EFFECTS INFORMATION relative to oral



and inhalation routes for chemicals of interest to Superfund, the



Resource  Conservation  and Recovery  Act  (RCRA) ,  and the  EPA in



general.  These entries in the HEAST are limited to chemicals that



have undergone review and have the concurrence of individual Agency



Program Offices,  and each is  supported by  an  Agency reference.



This health effects information has not, however, had enough review



to  be   recognized  as  high  quality,   Agency-wide  consensus



information.



     The Integrated Risk Information System (IRIS)  is the Agency's



official repository of Agency-wide consensus chronic human health



risk information.  IRIS evaluations are conducted by the Agency's



Work Group Review process,  i.e.,  they have  been examined by either



the Reference Dose/Reference Concentration  (RfD/RfC) Work Group or



                               -1-

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the Carcinogen Risk Assessment Verification Endeavor (CRAVE)  Work

Group.  These Agency Work Groups conduct  a  process  that  leads to

internal  Agency scientific  consensus  regarding  health  effects

information on a chemical.   This information is recorded on IRIS,

is considered to be "Work Group Verified," and does  not appear on

the HEAST.   Thus,  provisional health effects  information  on the

HEAST is  subject to possible  review  and revision  by these Agency

Work Groups.

     There are two exceptions to the above discussion.   The HEAST

also  contains  information  on  chemicals that  are a part  of the

National  Ambient  Air Quality  Standards (NAAQS)  or  the  Drinking

Water Criteria Document  (DWCD)  series.  In  each of these cases, the

chemicals are subject to extensive scientific peer review processes

of extremely high quality.



CHEMICAL STATUS DEFINITIONS

     Chemicals reviewed by the Agency Work  Groups are  classified

according to their status as either "verified," "not verifiable,"

or "under review."  The toxicity values (other than NAAQS or DWCD

values)  listed  on  the  HEAST are considered to be "provisional."

The Agency has  no  official definitions for these terms,  but the

HEAST user may interpret them  as follows:


     Provisional:   A toxicity value or  a  cancer  value is
      "provisional" if the value has  had some form of Agency
     review,  but it does not appear on the  IRIS system.  These
     values  are  generated  in  several ways.   Often  they are
     determined in the course of developing an Agency document
     on a chemical or on a class of chemicals.  Some have been
     generated  through the Work Group process, but  have not
     yet  been input to the  IRIS system.    At the time each
     value was  derived,  all  available information on the
      chemical was  evaluated,  the value  was  calculated using

                                -2-

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the most current methodology, and a consensus was reached
on the value by  Agency scientists.

Brackets  are  placed  around  the names  of  toxicity and
carcinogenicity values on the HEAST to distinguish these
"provisional"  values from  information  on  IRIS.   The
following  names are  affected:   RfD  to  [RfD] ,  RfC to
 [RfC], slope factor to [slope factor], EPA  group to  [EPA
Group] and unit  risk  to  [unit risk].

These "provisional" values are found on  the HEAST.  They
do not appear on IRIS.

Verified:  A  toxicity value  or  a cancer value is "Work
Group Verified" if  all available information on the value
has been examined by an Agency Work Group,  the  value has
been calculated  using current Work Group methodology, a
unanimous consensus has  been reached on  the value by the
Work Group, and  the value appears on IRIS.

Some numbers  that  have  achieved unanimous consensus by
the Work Group may appear on the HEAST for a short time
until they are loaded onto IRIS, at which time they are
termed,  "verified."   During  the  interim,   they  are
considered to be  "provisional"  values  that  are  still
"under review" by the Work Group.

These "verified" numbers only appear on IRIS.   They do
not appear on the HEAST.

Not verifiable:  A toxicity value is  "not verifiable" if
an Agency Work Group has considered all available data on
a chemical and has unanimously determined that data are
inadequate to  generate a value that would be suitable for
inclusion on IRIS.  No toxicity value is calculated; no
toxicity value is available for IRIS or the HEAST.

This  "not verifiable" status is noted on  IRIS,  and is
sometimes found on the HEAST, with  a pointer  to the IRIS
system.

Under Review:   A toxicity value is "under review" if an
Agency Work Group  is  in  the  process of  considering all
available data on a chemical.  All Work Group  chemicals
will have this status until the  toxicity value  is placed
on the  IRIS   system.   Toxicity  values  that  have  been
withdrawn from IRIS by a Work Group for further review
will have this status.

This "under review" status may be indicated on IRIS or on
the HEAST.   During  this time,   "provisional"  toxicity
values may appear on the HEAST.
                          -3-

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     In all cases, the status of a  chemical may change as new data



become available, and the assessment is revisited.








CAUTION




     It is imperative for each user of the HEAST to recognize that



the values listed in the toxicity tables and the cancer table are



generally considered to be PROVISIONAL HEALTH EFFECTS INFORMATION.



The user is referred to IRIS  for "Work Group Verified" values.  It



is also  important to remember  that the numbers  in  these  tables



alone tell very little about the adverse effects of a chemical or



the quality  of evidence  on  which  health effects  information is



based.   Original  assessment documents must be consulted by users of



the HEAST in order  to  fully  appreciate  the  strengths and limita-



tions of  a  specific data base.   Original source  documents  will



allow for the most complete characterization of potential toxicity



associated with the  range of  exposure pathways generally evaluated



at Superfund and RCRA sites.   The Reference  Tables point the user



to these sources.








CONTRIBUTORS



     Chemicals commonly  found at RCRA sites as  identified  by the



Office  of  Solid  Waste's (OSW)   Technical Assessment Branch are



included  in  the  HEAST.   The  Office of  Radiation  Programs has



provided data on radionuclide carcinogenicity for  Tables 4A and 4B



of the  HEAST.   Finally,  the Office of  Air Quality  Planning and



Standards (OAQPS) has provided information on chemicals for which



Air Quality  Criteria Documents and National Ambient Air Quality



Standards have been developed.



                               -4-

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CHEMICALS LISTED



     Most of  the chemicals  included  on the  toxicity  tables and



carcinogenicity  table  are those  for  which  at  least one  of the



following EPA documents has been written:  Health Effects Assess-



ment  Document  (HEA),  Health  and  Environmental  Effects  Profile



(KEEP),  Health  and  Environmental  Effects Document (HEED),  Health



Assessment Document  (HAD) , Air Quality Criteria Document  (AQCD) ,



Drinking Water Criteria Document (DWCD).  A description of each  is



provided in Appendix A, Section I.   In a  few  cases, the values are



supported by  other  written material,  such as Work  Group meeting



notes or Carcinogen Assessment Group (CAG)  Profiles.  Radionuclide



slope factor values  are calculated by the EPA's Office of Radiation



Programs.



     The  names  of   criteria  pollutants  that  are  regulated   as



National Ambient Air Quality  Standards (NAAQS)  mder the Clean Air



Act  are  listed  in  the main  body  of the  HEAST,  but  the  actual



criteria  are  included as Section V of  Appendix  A:  Technical



Information.  The NAAQS were not included in the  tables in order  to



distinguish them from the reference concentration ([RfC])  values.



The  NAAQS  and  [RfC]s  represent different  levels of  review and



different methods of calculation and thus,  must be interpreted and



used differently.








HIERARCHY OF SOURCES



     It   is  recognized that  at any point  in time  there  may   be



multiple old and new Agency  documents or data bases that present



different values on a specific chemical.  For chemicals other than



those represented by the NAAQS or DWCDs,  the following hierarchy  of



                               -5-

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sources  is  recommended  in  evaluating  chemical  toxicity  for

Superfund sites:


     1.  The  Agency's  Integrated Risk  Information  System
         (IRIS) and  cited references.   Changes  are  made in
         this data base on a monthly basis, but there may be
         data  gaps.   Call  the  RISK INFORMATION  HOTLINE at
         (513)569-7254 for further information.

     2.  The Health Effects Assessment Summary Tables  (HEAST)
         and cited references.

     3.  Consultation with  the  Superfund Health  Risk Tech-
         nical Support Center (TSC) at (513)569-7300.

     4.  Do not consult either the toxicity tables (Appendix
         A) in the Superfund Public Health Evaluation Manual
         (SPHEM, U.S. EPA, 1986)  or the September 1988 Public
         Health Risk Evaluation  Data Base  (PHRED)  as these
         sources are  likely  to contain  numerous values that
         have since become out-of-date.
QUESTIONS

Chemical Toxicity and Carcinogenicity

     Regional EPA Superfund  Staff  may direct questions regarding

the contents of the chemical toxicity and carcinogenicity tables on

the HEAST  (e.g.,  chemicals  not  covered, chemicals  with  pending

[RfD]s) to  EPA's  Superfund Health Risk  Technical  Support Center

(TSC)   in Cincinnati,  OH at  (513)569-7300.   Questions from other

users must be submitted to the TSC  in writing and must contain the

following information:
     •  Superfund site name,  site location and twelve-digit
        site number;

     •  Name and  phone  number of  the  site Remedial Project
        Manager (RPM)  or  Regional  Risk Assessor/Toxicologist;

     •  Detailed description of the health effects information
        related question.
                               -6-

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     Please send requests via mail or FAX to:

      Superfund Health Risk Technical Support Center
      US EPA
      26 W. Martin Luther King Dr.
      Environmental Criteria and Assessment Office
      MS 117
      Cincinnati, OH  45268
      FAX#:   (513)569-7159
RCRA Chemicals

     Questions about RCRA chemicals may be addressed by calling the

Office of Solid Waste at  (202) 260-4761.

Radionuclide Carcinogenicity

     Questions concerning radionuclide carcinogenicity should first

be  addressed by  contacting  the  appropriate Regional  Radiation

Program Manager.  A listing of these managers and several contacts

in the Office of  Radiation Programs can be  found in Exhibit 2 of

the User's Guide  - Radionuclide Carcinogenicity.



REFERENCES

     Most cited Agency references (e.g., HEAs,  HEEPs, HEEDs),  are

(or  will  soon  be)   available through the  National  Technical

Information Service  (NTIS), 5285 Port Royal Road, Springfield, VA

22161 [(703)487-4650].  Carcinogen Assessment Group  (CAG) Profiles

cited  in  Table   3  are  available  through   the   RCRA  docket

(202)260-9327.

     Drinking water documents  are available by calling the Drinking

Water Docket at (202)260-3027.

ORDERING INFORMATION

     Limited copies  of  the HEAST are  available  for EPA Superfund

staff, State Superfund programs and other Federal agencies working


                               -7-

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on  Superfund sites.   Users  in  these  groups  can  call  Syracuse

Research Corporation (616)  375-2121 to be put on the mailing list.

     EPA's Office of Solid  Waste  (OSW)  requests  that their users

(i.e., OSW staff, contractors, State solid waste programs) call the

Health Assessment Section  (202) 260-4761 to  obtain copies of the

HEAST.  Regional OSW staff are reminded that copies are sent to all

EPA Regional libraries.

     Users of the HEAST  in  EPA's  Office of Air and Radiation and

State air programs should call Kelly Rimer of EPA's Office of Air

Quality Planning and Standards at  (919) 541-2962.

     All other users must purchase the document from:

      National Technical Information Service (NTIS)
      5285 Port Royal Road
      Springfield,  VA  22161
      (703) 487-4650


     Fc   ordering  information,   call   the   JTTIS  Subscriptions

Department at (703)  487-4630.  NTIS normally ships 4th class United

States  mail.    Therefore,  users  may  wish to  consult with  NTIS

concerning the use of an overnight delivery  service.  When ordering

the 1994 Health Effects Assessment Summary  Table annual update and

supplements from NTIS refer to the following order numbers:

                 PB94-921100: Annual HEAST Update and Supplements

                 PB94-921199: Annual HEAST update

                 PB94-921101: July 1994 Supplement No. 1

                 PB94-921102: November  1994 Supplement No. 2

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           WHAT'S  NEW IN THE  JULY  1994  SUPPLEMENT  NO.  1

GENERAL CHANGES -- CHEMICAL TOXICITY AND CARCINOGENICITY

     The changes in this version of the HEAST reflect changes in

IRIS through May 1, 1994.  It is also current with RfD/RfC and

CRAVE Work Group activities through May 1, 1994.


CHEMICAL-SPECIFIC CHANGES -- CHEMICAL TOXICITY AND
CARCINOGENICITY

A.   CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 1:  SUBCHRONIC AND
     CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)

Acrvlic acid  000079-10-7
The chronic oral RfD has been replaced on IRIS.  The chronic oral
RfD on IRIS was adopted as the subchronic oral  [RfD].

Aroclor 1248   012672-29-6
An indicator was added to show that a comment is now on IRIS that
the chronic oral RfD is considered not verifiable by the RfD/RfC
(07/20/93)  Work Group.

Aroclor 1254  0111097-69-1
The chronic  [RfD]  under review by the RfD/RfC Work Group was
added to the table.  The subchronic  [RfD] was derived from the
chronic [RfD].

Carbon Disulfide  000075-15-0
No change  in the table.  Reference to the 1989 RfD/RfC Work Group
was added.

Dibromoethane.  1.2-    000106-93-4
The subchronic  [RfC] was modified to be consistent with the
chronic [RfC].

Dimethvlphthalate  000131-11-3
The chronic oral  [RfD] has been removed.  A comment was added to
show that  the chronic  oral  [RfD] is considered not verifiable by
the RfD/RfC  (02/16/94) Work Group.

Methylenediphenvl isocvanate, 4,4- /
(Diphenylmethanediisocyanate)  000101-68-8
An indicator was added to show that the chronic inhalation RfC  is
now on IRIS.  The chronic inhalation RfC on IRIS was adopted as
the subchronic inhalation  [RfC].
Trichloroethane. 1.1,1.-   000071-55-6
A comment pertaining to the subchronic  [RfC] was added to  the
table.
                                -9-

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B.   CHEMICAL-SPECIF1C CHANGES ON HEAST TABLE 2:  ALTERNATE
     METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
     CARCINOGENICITY)

     No changes were made to HEAST Table 2.


C.   CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3: CARCINOGENICITY

Bis(2-chloroisopropvl) ether  039638-32-9
Removed from Table 3.  Compound tested was Technical bis(2-chloro-
l-methylethyl) ether containing 70% bis(2-chloro-l-methylethyl)
ether and 30% bis(2-chloroisopropyl) ether.   [Slope factor],
[unit risk],  and [EPA Group] classification were only derived for
bis(2-chloro-l-methylethyl) ether.

Bis(2-chloro-l-methvlethvl) ether  000108-06-1
Replaced on Table 3. Compound tested was Technical bis(2-chloro-
l-methylethyl) ether containing 70% bis(2-chloro-l-methylethyl)
ether and 30% bis(2-chloroisopropyl) ether.   [Slope factor],
[unit risk],  and [EPA Group] classification were only derived for
bis(2-chloro-l-methylethyl) ether.

Dimethylhvdrazine.  1.2-  000540-73-8
The general comment, "Contact the Superfund Health Risk Technical
Support Center" has been removed from the table.


D.   CHEMICAL-SPECIFIC CHANGES ON HEAST TABLES 4A AND 4B:
     RADIONUCLIDE CARCINOGENICITY -- SLOPE FACTORS

     No new radionuclide slope factors were added to Tables 4A
and 4B, and none of the slope factors listed in the March 1994
HEAST Annual Update were changed.
                               -10-

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                                  HEAST  TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                          July 1994
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET
                                    000079-10-7
                                                          CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfDl       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (mg/kg/day)   (mg/cu m)  (mg/kg/day)
   UF          UF           UF        UF
ACRYLIC ACID
     NOAEL  53  MG/KG/DAY        RAT
             ORAL: DRINKING   2  GENERATION  WHOLE BODY       DECREASED PUP WEIGHT
             WATER
                                                                                                        5E-1
                                                                                                        100
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD ON  IRIS  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                                                                              IRIS
                                                                                                                                        005836
     LOAEL 5 PPM               MOUSE
             INHALATION:        13  WEEKS
             INTERMITTENT
                                            NASAL MUCOSA
                                                             LESIONS
    3E-3
    100
                                                                                                                   IRIS
                                                                                                                                        010346
AROCLOR 1248                     012672-29-6

            CHRONIC RfD COMMENT:   THE CHRONIC ORAL RfD IS CONSIDERED  NOT  VERIFIABLE  (07/20/93) BY THE RfD/RfC WORK GROUP.
                                                                                                                              IRIS
                                                                                                                                        010940
AROCLOR 1254

     LOAEL 0.005 MG/KG/DAY
                                    011097-69-1

                               MONKEY        IMMUNE SYSTEM    TOXICITY
              5E-5
              100
           2E-5       010963
           300
CARBON DISULFIDE
     NOEL  11 MG/KG/DAY
              INHALATION:
              INTERMITTENT
                                     000075-15-0
                               RABBIT
                                            FETUS
                                                             TOXICITY
               1E-1
               100
                                                                                                                              IRIS
                                                                                                                                        010259
            SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
            CHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS DETERMINED FROM A  TERATOLOGY STUDY WITH EXPOSURES BEFORE AND DURING THE ENTIRE  GESTATION
                               PERIOD.
     NOAEL 10 MG/CU M          RAT
              INHALATION:       GESTATION
              INTERMITTENT
                                             FETUS
                                                             TOXICITY
    1E-2
    1000
1E-2
1000
                                                                                                                                         010430
            SUBCHRONIC  [RfC] COMMENT:   THE  CHRONIC  INHALATION [RfC] WAS ADOPTED AS THE  SUBCHRONIC  INHALATION  [RfC].
 IRIS, ERA'S INTEGRATED RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK  INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                1-1

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                                  HEAST  TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)                March 1994

                                                                                                   Subchronic          Chronic
CHEMICAL    DOSE          SPECIES                                                          [RfC]       [RfD]        [RfC]        [RfD]     REFERENCE
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT                 (mg/cu m)  (mg/kg/day)   (mg/cu m) (mg/kg/dav)
                                                                                            UF        UF          UF         UF

DIBROMOETHANE,  1.2-               000106-93-4
     LOAEL 88  PPB               HUMAN
             INHALATION:                     SPERM            EFFECTS                         2E-3                  2E-4                  010854
             INTERMITTENT                                                                    100                   1000

            SUBCHRONIC  [RfC]  COMMENT:  THE CHRONIC  INHALATION [RfC] WAS MODIFIED TO ESTIMATE THE  SUBCHRONIC INHALATION  [RfC].
            CHRONIC [RfC]  COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  3:  CARCINOGENICITY.

DIMETHYLPHTHALATE                 000131-11-3
            CHRONIC RfD COMMENT:  THE CHRONIC ORAL  [RfD] IS CONSIDERED NOT VERIFIABLE  (02/16/94)  BY THE RfD/RfC WORK GROUP.                010267
                                                                                                                  IRIS                  010894
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE  (07/26/90) BY THE RfD/RfC WORK GROUP.


METHYLENEDIPHENYL ISOCYANATE, 4,4- / (DIPEHNYLMETHANE  DIISOCYANATE)     000101-68-8
     NOAEL 0.2 MG/CU M          RAT
             INHALATION:        24 MONTHS     NASAL  CAVITY     LESIONS                         2E-5                  IRIS                  010449
             INTERMITTENT                                                                    300

            SUBCHRONIC  [RfC]  COMMENT:  THE CHRONIC  INHALATION RfC ON IRIS WAS ADOPTED  AS THE SUBCHRONIC INHALATION  [RfC].


TRICHLOROETHANE,  1.1.1-          000071-55-6

            SUBCHRONIC  [RfD]  COMMENT:  CONTACT THE  SUPERFUND HEALTH RISK TECHNICAL  SUPPORT CENTER: (513) 569-7300.
            SUBCHRONIC  [RfC]  COMMENT:  CONTACT THE  SUPERFUND HEALTH RISK TECHNICAL  SUPPORT CENTER: (513) 569-7300.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.                 1-2

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                                          REFERENCES FOR HEAST  TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                             (OTHER THAN CARCINOGENICITY)                                             July 1994

ACRYLIC ACID                                          000079-10-7
        005836  BASF.   1993.   REPRODUCTION TOXICITY STUDY WITH ACRYLIC ACID IN RATS:  CONTINUOUS ADMINISTRATION IN THE  DRINKING WATER OVER 2
                GENERATIONS (1  LITTER  IN THE FIRST AND 1  LITTER  IN  THE SECOND GENERATION).  PROJECT NO.  71R0114/92011.   BASF AKTIENGELLSCHAFT, DEPT.
                OF TOXICOLOGY,  RHEIN,  FRG.

                US EPA.  1994.  RfD/RfC  WORK GROUP.

        010346  MILLER,  RR, JA AYERS,  GC JERSEY AND MJ MCKENNA.  1981.  INHALATION TOXICITY OF ACRYLIC ACID.  FUND APPL TOXICOL. 1(3): 271-277.

                MILLER,  RR, JA AYERS,  GC JERSEY. 1979. ACRYLIC ACID 90-DAY  VAPOR INHALATION STUDY WITH RATS AND MICE.  FINAL REPORT #79RC-1024.
                TOXICOLOGY RESEARCH  LABORATORY, HEALTH AND ENVIRONMENTAL SCIENCE, DOW CHEMICAL COMPANY, MIDLAND, MI.

                US EPA.  1990.  RfD/RfC  WORK GROUP.


AROCLOR 1248                                          012672-29-6
        010940  US EPA.  1993.  RfD/RfC  WORK GROUP.

AROCLOR 1254                                          011097-69-1
        010963  US EPA.   1994.  RfD/RfC WORK GROUP.

CARBON DISULFIDE                                      000075-15-0
        010259  HARDIN BD, GP  BOND,  MR SIKOR, FD ANDREW,  RP BELILES AND RW NIEMEIR.  1981. TESTING OF SELECTED WORKPLACE CHEMICALS  FOR TERATOGENIC
                POTENTIAL. SCAND  J WORK ENVIRON HEALTH. 7CSUPPL  4): 66-75.

                US EPA.  1985.  RfD/RfC  WORK GROUP.

        010430  TABACOVA S, LA HINKOVA, L BALABAEVA. 1978. CARBON DISULFIDE TERATOGENICITY AND POSTNATAL EFFECTS IN RATS. TOXICOL  LETT.  2(3):
                129-133.

                TABACOVA S, B  NIKIFOROV, L BALABAEVA. 1983. CARBON  DISLUFIDE  INTRAUTERINE SENSITIZATION. J  APPL TOXICOL. 3(5):  233-239.

                US EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE  FOR CARBON DISULFIDE. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE,
                WASHINGTON, DC.

                US EPA.  1989.  RfD/RfC  WORK GROUP.

DIBROMOETHANE, 1,2-                                  000106-93-4
        010854  RATCLIFFE JM,  SM  SCHRADER, K STEENLAND, DE CLAPP, T TURNER AND RW HORNUNG.  1987. SEMEN QUALITY  IN PAPAYA WORKERS WITH LONG-TERM
                EXPOSURE TO ETHYLENE BROMIDE. BR J IND MED. 44:  317-326.

                SCHRADER SM, TW TURNER AND JM RATCLIFFE.  1988.  THE  EFFECTS OF ETHYLENE BROMIDE ON SEMEN QUALITY: A COMPARISON OF SHORT-TERM AND
                CHRONIC EXPOSURE. REPROD TOXICOLOGY. 2: 191-198.

                US EPA.  1992.  RFD/RFC  WORK GROUP.
                                                                                                                                               R1-1

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                                         REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                            (OTHER THAN CARCINOGEN 1C ITY)
                                                                                                                                      Juiy 1994
DIMETHYLPHTHALATE
        010267  US EPA. 1994.  RfD/RfC WORK GROUP.

        010894  US EPA. 1990.  RfD/RfC WORK GROUP.
                                                      000131-11-3
METHYLENEDIPHENYL ISOCYANATE, 4,4-  / (DIPHENYLMETHANE  DIISOCYANATE)     000101-68-8
        010449  REUZEL PGJ, JHG ARTS, MHM KUYPERS,  ET AL. 1990. CHRONIC TOXICITY/CARCINOGENICITY INHALATION STUDY OF POLYMERIC METHYLENEDIPHENYL
               DIISOCYANATE AEROSOL  IN RATS. FINAL REPORT. PREPARED  BY CIVO  INSTITUTE FOR  THE  INTERNATIONAL ISOCYANATE INSTITUTE.

               REUZEL PGJ, JHG ARTS, LG LOMAX,  ET  AL. 1998. CHRONIC  INHALATION AND CARCINOGENICITY STUDY OF RESPIRABLE POLYMERIC METHYLENE DIPHENYL
               DIISOCYANATE (POLYMERIC MDI) AEROSOL IN RATS. FUND  APPL TOXICOL. 22: 195-210.

               US  EPA. 1993. RfD/RfC WORK GROUP.
                                                                                                                                          R1-2

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                                                           HEAST TABLE 3:  CARCINOGENICITY                                           July 1994

                                                                                          [SLOPE FACTOR]                [UNIT RISK]
                        EXPERIMENT LENGTH                                      [EPA      ORAL         INHALATION     ORAL        INHALATION    REFERENCE
CHEMICAL    ROUTE           SPECIES            TARGET             CANCER        GROUP]  (mg/kg/day)^(tng/kg/day)"1      (ug/L) '     (ug/cu m)-1

BIS(2-CHLORO-1-METHYLETHYL)  ETHER     000108-06-1
            ORAL: GAVAGE    2 YEARS                                           C         7E-2           3.5E-2        2E-6      1E-5         005079
                            MOUSE              LIVER              TUMORS
                                               LUNG              TUMORS

            INHALATION [SLOPE] COMMENT:  BASED ON ROUTE  TO  ROUTE EXTRAPOLATION (50% RESPIRATORY ABSORPTION).  SEE APPENDIX A-II: DOSE CONVERSIONS ON  HEAST.
            GENERAL COMMENT:  COMPOUND TESTED CONTAINED  70% BIS(2-CHLORO-1-METHYLETHYL)ETHER AND 30% BIS(2-CHLOROISOPROPYL)ETHER. ALSO SEE HEAST TABLE  1:
                        SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

DIMETHYLHYDRAZINE.  1,2-             000540-73-8
                                                                              B2                                                            010962
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED  MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE:  (513)  569-7254.                         3-1

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                                                   REFERENCES FOR  HEAST TABLE 3:   CARCINOGENICITY                                   July 1994


BIS(2-CHLORO-1-METHYLETHYL) ETHER                     000108-06-1
        005079  NTP (NATIONAL TOXICOLOGY  PROGRAM). 1982. CARCINOGENIC BIOASSAY OF BIS(2-CHLORO-1-METHYLETHYL)  ETHER  (70%) CONTAINING
                2-CHLORO-1-METHYLETHYL(2-CHLOROPROPYL) ETHER (30%) IN B6C3 1  MICE (GAVAGE STUDY).  NCI  CARCINOGEN  TECH  REP SER NO 239. 105 P. ALSO
                PUBL AS DHHS (NIH) 83-1795

                US EPA. 1987. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR HALOETHERS.  PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE  OF  SOLID  WASTE AND EMERGENCY RESPONSE,
                WASHINGTON,  DC.

DIMETHYLHYDRAZINE,  1.2-                                 000540-73-8
        010479  TOTH B AND K PATEL. 1982. CARCINOGENICITY DOSE RESPONSE STUDY BY CONTINUOUS ADMINISTRATION  OF  1,2-DIMETHYL HYDRAZINE DIHYDROCHLORIDE
                IN MICE. I.  LIGHT  AND TRANSMISSION ELECTRON MICROSCOPIC STUDY OF COLONIC NEOPLASMS.  AM J PATH. 84: 69-86.

                US EPA. 1984. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR 1,2-DIMETHYLHYDRAZINE.  PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE  OF  SOLID  WASTE AND EMERGENCY RESPONSE,
                WASHINGTON,  DC.

                US EPA. 1989. EVALUATION  OF  THE POTENTIAL CARCINOGENICITY OF  1,2-DIMETHYLHYDRAZINE.  PREPARED BY THE  CARCINOGEN ASSESSMENT GROUP,
                OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF
                EMERGENCY AND REMEDIAL RESPONSE AND  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
 • U.S. GOVERNMENT PRINTING OFFICE: 7994-386-547/03099
                                                                                                                                               R3-1

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