United States
Environmental Protection
Agency
Great Lakes National Program Office
77 West Jackson Boulevard
Chicago, Illinois 60604
EPA-905-B02-001-C
December 2002
A Guidance Manual to Support
the Assessment of
Contaminated Sediments in
Freshwater Ecosystems
Volume III - Interpretation of the Results of Sediment
Quality Investigations
                      by:
                 Donald D. MacDonald
            MacDonald Environmental Sciences Ltd.
              #24 - 4800 Island Highway North
              Nanaimo, British Columbia V9T 1W6

                 Christopher G. Ingersoll
              United States Geological Survey
                 4200 New Haven Road
                Columbia, Missouri 65201

                  Under Contract To:
              Sustainable Fisheries Foundation
                 120 Avenue A - Suite D
               Snohomish, Washington 98290

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     A Guidance Manual to Support the
  Assessment of Contaminated Sediments
           in Freshwater Ecosystems

     Volume III - Interpretation of the Results of
           Sediment Quality Investigations
                        Submitted to:

                       Scott Cieniawski
            United States Environmental Protection Agency
                Great Lakes National Program Office
                 77 West Jackson Boulevard (G-17J)
                     Chicago, Illinois 60604
                 Prepared - December 2002 - by:

          Christopher G. Ingersoll1 and Donald D. MacDonald2

United States Geological Survey      2MacDonald Environmental Sciences Ltd.
4200 New Haven Road                    #24 - 4800 Island Highway North
Columbia, Missouri 65201               Nanaimo, British Columbia V9T 1W6
                      Under Contract to:
                 Sustainable Fisheries Foundation
                     120 Avenue A, Suite D
                  Snohomish, Washington 98290

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                                                                            DISCLAIMER - i
Disclaimer
       This publication was developed by the Sustainable Fisheries Foundation under USEPA Grant
       Number GL995632-01.  The contents, views, and opinions expressed in this document are
       those of the authors and do not necessarily reflect the policies or positions of the USEPA,
       the United States Government, or other organizations named in this report. Additionally, the
       mention of trade names for products or software does not constitute their endorsement.
      GUIDANCE MANUAL TO SUPPORT THE ASSESSMENT OF CONTAMINATED SEDIMENTS IN FRESHWATER ECOSYSTEMS-VOLUME III

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                                                                     TABLE OF CONTENTS - ii
Table  of Contents


       Disclaimer	i
       Table of Contents	  ii
       List of Tables  	v
       List of Figures	  vii
       Executive Summary	viii
       List of Acronyms 	  xii
       Glossary of Terms 	  xvii
       Acknowledgments 	xxiii


       Chapter 1.    Introduction                                                     1
              1.0    Background  	1

       Chapter 2.    Assessment of Whole-Sediment and Pore-Water Chemistry	4
             2.0    Introduction  	4
             2.1    Selection of Metrics and Targets for Sediment Chemistry 	4
             2.2    Availability of Standard Methods 	9
             2.3    Advantages and Disadvantages of Sediment Chemistry Data	10
             2.4    Evaluation of Data Quality  	12
             2.5    Methodological Uncertainty	13
                    2.5.1  Uncertainty Associated with Sediment Chemistry 	14
                    2.5.2  Uncertainties Associated with Uses  of Sediment Quality
                          Guidelines 	16
             2.6    Interpretation of Data	20
             2.7    Recommendations 	23

       Chapter 3.    Whole-Sediment and Pore-Water Toxicity Testing  	26
             3.0    Introduction  	26
             3.1    Selection of Metrics and Targets for Sediment Toxicity	26
             3.2    Availability of Standard Methods 	30
             3.3    Advantages and Disadvantages 	34
             3.4    Evaluation of Data Quality  	35
             3.5    Methodological Uncertainty	37
             3.6    Interpretation of Data	40
             3.7    Recommendations 	42
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                                                                TABLE OF CONTENTS - Hi
 Chapter 4.   Benthic Invertebrate Community Assessment  	45
       4.0    Introduction  	45
       4.1    Selection  of  Metrics and Targets  for  Benthic  Invertebrates
              Community Structure	45
       4.2    Availability of Standard Methods  	47
       4.3    Advantages and Disadvantages 	48
       4.4    Evaluation of Data Quality  	50
       4.5    Methodological Uncertainty	52
       4.6    Interpretation of Data	54
       4.7    Recommendations 	56

 Chapter 5.   Bioaccumulation Assessment 	59
       5.0    Introduction  	59
       5.1    Selection of Metrics and Targets for Bioaccumulation Assessment .... 59
       5.2    Availability of Standard Methods  	62
       5.3    Advantages and Disadvantages 	65
       5.4    Evaluation of Data Quality  	67
       5.5    Methodological Uncertainty	68
       5.6    Interpretation of Data	71
       5.7    Recommendations 	75

 Chapter 6.   Fish Health and Fish Community Assessments                     78
       6.0    Introduction  	78
       6.1    Selecting Metrics and  Targets in Fisheries Assessments	78
       6.2    Availability of Standard Methods  	81
       6.3    Advantages and Disadvantages 	82
       6.4    Evaluation of Data Quality  	83
       6.5    Methodological Uncertainty	84
       6.6    Interpretation of Data	85
       6.7    Recommendations 	86

 Chapter 7.   Integration  of Information on Multiple Indicators of Sediment
              Quality Conditions                                               88
       7.0    Introduction  	88
       7.1    Integration of Information on Multiple Indicators of Sediment Quality
              Conditions 	89
              7.1.1   Integration of Information  on  Multiple  Indicators  for
                     Assessing Impacts  on Sediment-Dwelling  Organisms and
                     Other Receptors	91
              7.1.2   Integration of Information on Multiple Indicators of Sediment
                     Quality in the Assessment of Impacts on Wildlife	96
              7.1.3   Integration of Information on Multiple Indicators of Sediment
                     Quality in the Assessment of Impacts on Human Health  	98
       7.2    Summary 	99

 Chapter 8.   References                                                      100

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                                                              TABLE OF CONTENTS - iv
 Appendix 1.  Recommended Uses of Sediment Quality Guidelines	172
       Al.O   Introduction  	172
       Al.l   Monitoring Program Design  	172
       A1.2   Interpretation of Sediment Chemistry Data	173
       A1.3   Support for Analysis of Dredged Material Disposal Options  	177
       A1.4   Ecological Risk Assessment  	178
       A1.5   Development of Sediment Quality Remediation Objectives	180

 Appendix!.  Methods for Determining Background Levels  of Sediment-
              Associated Contaminants  	182
       A2.0   Introduction  	182
       A2.1   Reference Sediment Approach	183
       A2.2   Reference Element Approach  	184

 Appendix 3.  Approaches to the Development of Numerical Sediment Quality
              Guidelines	186
       A3.0   Introduction  	186
       A3.1   Screening Level Concentration Approach	187
       A3.2   Effects Range Approach 	188
       A3.3   Effects Level Approach	189
       A3.4   Apparent Effects Threshold Approach  	190
       A3.5   Equilibrium Partitioning Approach	191
       A3.6   Logistic Regression Modeling Approach	192
       A3.7   Consensus Approach	194
       A3.8   Tissue Residue Approach  	195

 Appendix 4.  Criteria for Evaluating Candidate Data Sets                      198
       A4.0   Introduction  	198
       A4.1   Criteria for Evaluating Whole  Sediment, Pore Water, and Tissue
              Chemistry	199
       A4.2   Criteria for Evaluating Biological Effects Data	200
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                                                                      TABLE OF CONTENTS - v
List  of Tables
       Table 1       Sediment   quality   guidelines  that  reflect   threshold effect
                    concentrations (TECs; i.e., below which harmful effects are unlikely
                    to be observed; from MacDonald et al. 2000b)	122

       Table 2       Sediment quality guidelines that reflect probable effect concentrations
                    (PECs; i.e., above which harmful effects are likely to be observed;
                    from MacDonald et al. 2000b)	124

       Table 3       Advantages and disadvantages of whole-sediment and pore-water
                    chemistry (Ingersoll et al. 1997)  	126

       Table 4       Uncertainty  associated  with sediment  chemistry measurements
                    (Ingersoll et al. 1997)	127

       Table 5       Uncertainty associated with sediment quality guidelines (Ingersoll et
                    al. 1997)	128

       Table 6       Summary of potential targets for pore-water chemistry	129

       Table 7       Rating of selection criteria for freshwater sediment toxicity testing
                    organisms (ASTM 2001a; USEPA 2000a)  	132

       Table 8       Summary  of standard methods  for conducting whole-sediment
                    toxicity or  sediment  bioaccumulation  tests  with  freshwater
                    invertebrates	133

       Table 9       Advantages and disadvantages of laboratory sediment toxicity tests
                    (ASTM 2001a; USEPA 2000a)	134

       Table 10     Test conditions for conducting a 28- to 42-day sediment toxicity test
                    with Hyalella azteca (ASTM 200la; USEPA 2000a)	135

       Table 11     Test acceptability requirements for a 42-day sediment  toxicity test
                    with Hyalella azteca (ASTM 200la; USEPA 2000a)	137

       Table 12     Uncertainty associated with sediment phases used in laboratory
                    toxicity tests (Ingersoll et al. 1997)	139

       Table 13     Uncertainty associated with endpoints measured in laboratory toxicity
                    tests with sediment (Ingersoll et al. 1997)	140

       Table 14     Uncertainty  associated  with benthic  community assessments
                    (Ingersoll et al. 1997)	141

       Table 15     Advantages and disadvantages of benthic invertebrate community
                    structure data 	142

       Table 16     Selection  criteria for sediment  bioaccumulation test organisms
                    (ASTM 2001d; USEPA 2000a)	143

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                                                                TABLE OF CONTENTS - vi
 Table 17     Advantages and disadvantages of tissue chemistry data 	144

 Table 18     Recommended test  conditions for conducting a 28-day sediment
              bioaccumulation test with Lumbriculus variegatus (ASTM 200Id;
              USEPA 2000a)	145

 Table 19     Test   acceptability  requirements   for   a   28-day sediment
              bioaccumulation test with the oligochaete, Lumbriculus variegatus
              (ASTM 2001d; USEPA 2000a)	147

 Table 20     Uncertainty associated with bioaccumulation assessments (Ingersoll
              etal. 1997)	149

 Table 21     Methods for evaluating the effects of exposure to COPCs in fish
              (from Schmitt et al.  2000)	150

 Table 22     Methodological  uncertainty  associated with fish health and fish
              community assessments	152

 Table 23     Contingency table for assessing impacts of contaminated sediments
              on aquatic life based on three  separate indicators of sediment quality
              (sediment quality triad adapted from Chapman 1992 and Canfield et
              al. 1996)	153

 Table 24     Contingency table for assessing impacts of contaminated sediments
              on aquatic life based  on four  separate  indicators  of sediment
              quality	154

 Table 25     Contingency table for assessing impacts of contaminated sediments
              on aquatic life based on two separate indicators of sediment quality .  . 158

 Table 26     Contingency table for assessing impacts of contaminated sediments
              on wildlife based on three separate indicators of sediment quality .... 159

 Table 27     Contingency table for assessing impacts of contaminated sediments
              on human health based on  two separate indicators of sediment
              quality	160
 Table Al.l   Incidence of toxicity predicted in laboratory toxicity tests using mean
              probably effect concentration-quotients (PEC-Qs; USEPA 2000b) .
203
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                                                                      TABLE OF CONTENTS - vii
List of Figures
       Figure 1      Recommended procedure for assessing sediment chemistry data	162

       Figure 2      Relationship between mean PEC quotients and the incidence of
                    toxicity in freshwater toxicity tests (USEPA 2000b)	163

       Figure 3      Recommended procedure for assessing sediment toxicity data	164

       Figure 4      Recommended procedure for assessing benthic invertebrate or fish
                    community structure  	165

       Figure 5      Recommended procedure for assessing tissue chemistry data	166

       Figure 6      Recommended procedure for evaluating fish health data 	167

       Figure 7      The relationship between the mean PEC quotient and the response of
                    Hyalella  azteca  in the 10-day tests  (as percent survival)  or  the
                    response in the Microtox® solid-phase sediment toxicity test (as the
                    EC50 expressed as a toxicity reference index).  Sediment samples
                    were collected from the Grand Calumet River and Indiana Harbor
                    Canal located in northwestern Indiana (Ingersoll et al. 2002)	168

       Figure 8      The relationship between the molar concentration of simultaneously
                    extracted metals to acid volatile sulfide (SEM-AVS) and toxic units
                    of metals in the sediment  samples.  Toxicity of  samples  was
                    determined using 10-day whole-sediment tests with Hyalella azteca
                    (Ingersoll et al. 2002)	169

       Figure 9      Tri-axial  graphs  of sediment  quality triad data (Canfield et al.
                    1994)  	170
       Figure A2.1.  Metal/aluminum regression lines with the 95% prediction limits
                    (from Carvalho and Schropp 2001)	205
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                                                                     EXECUTIVE SUMMARY - viii
Executive Summary
       Traditionally, concerns relative  to the management of aquatic resources in freshwater
       ecosystems have focused primarily on water quality.   As  such, early  aquatic resource
       management efforts were often directed at assuring the potability of  surface water or
       groundwater sources. Subsequently, the scope of these management initiatives expanded to
       include protection  of instream (i.e.,  fish and aquatic life), agricultural, industrial,  and
       recreational  water  uses.  While initiatives undertaken  in  the  past twenty years have
       unquestionably improved water quality conditions, a growing body of evidence indicates that
       management efforts directed solely at the attainment of surface water quality criteria may not
       provide an adequate basis for protecting the designated uses of aquatic ecosystems.

       In recent years, concerns relative to the health and vitality of aquatic ecosystems have begun
       to reemerge in North America. One of the principal reasons for this is that many toxic and
       bioaccumulative chemicals [such as  metals, polycyclic aromatic hydrocarbons (PAHs),
       polychlorinated biphenyls (PCBs), chlorophenols, organochlorine pesticides (OC pesticides),
       and polybrominated diphenyl ethers]; which are found in only trace amounts in water, can
       accumulate to elevated levels in sediments.  Some of these pollutants, such as OC pesticides
       and PCBs,  were released into the environment long  ago.   The use of many of these
       substances has been banned in North America for more than 30 years; nevertheless, these
       chemicals continue to persist in the environment. Other contaminants enter our waters every
       day from industrial and municipal discharges, urban and agricultural runoff, and atmospheric
       deposition from remote sources. Due to their physical and chemical properties, many of
       these substances tend to accumulate in sediments.  In addition to providing sinks for many
       chemicals, sediments can also  serve as potential sources of pollutants to the water column
       when conditions change in the  receiving water system (e.g., during periods of anoxia, after
       severe storms).

       Information  from  a variety of sources indicates that sediments in aquatic ecosystems
       throughout North America are  contaminated by a wide range of toxic and bioaccumulative
       substances, including metals, PAHs, PCBs, OC pesticides, a variety of semi-volatile organic
       chemicals (SVOCs), and polychlorinated  dibenzo-p-dioxins and furans (PCDDs  and
       PCDFs).  For example, contaminated sediments pose a major risk to the beneficial uses of
       aquatic ecosystems throughout the Great Lakes basin, including the 43  areas of concern
       (AOCs)  identified by the International  Joint  Commission.    The imposition of fish
       consumption advisories has adversely affected commercial, sport, and food fisheries in many
       areas.  In addition, degradation of the benthic community and other factors have adversely

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                                                                EXECUTIVE SUMMARY - ix
 affected fish and wildlife populations.  Furthermore, fish in many of these areas often have
 higher  levels  of tumors  and  other  abnormalities than  fish  from  reference  areas.
 Contaminated sediments have also threatened the viability of many commercial ports through
 the imposition of restrictions on dredging of navigational channels and disposal of dredged
 materials.  Overall, contaminated sediments have been linked to 11 of the 14 beneficial use
 impairments that have been documented at the Great Lakes AOCs. Such use impairments
 have also been observed elsewhere in Canada and the United States.

 In response to concerns raised regarding contaminated sediments, responsible authorities
 throughout North America have launched programs to support the assessment, management,
 and remediation of contaminated sediments.   The information generated under these
 programs provide important guidance for designing and implementing investigations at sites
 with contaminated sediments.  In  addition, guidance has been developed under various
 sediment-related programs to support the collection and interpretation of sediment quality
 data.  While such guidance has unquestionably  advanced the field of sediment quality
 assessments, the users of the individual guidance documents have expressed a need to
 consolidate this information into an integrated ecosystem-based framework for assessing and
 managing sediment quality in freshwater ecosystems (i.e., as specified under the Great Lakes
 Water Quality Agreement).  Practitioners in this field have also indicated the need for
 additional guidance on the applications of the various tools  that  support sediment quality
 assessments.  Furthermore, the need for additional  guidance  on the design of sediment
 quality monitoring programs and  on the  interpretation of the  resultant  data  has been
 identified.

 This guidance manual, which comprises a three-volume series and was developed for the
 United States Environmental Protection Agency, British Columbia Ministry of Water, Land
 and Air Protection, and Florida Department of Environmental Protection, is not intended to
 supplantthe existing guidance on sediment quality assessment. Rather, this guidance manual
 is intended to further support the design and implementation of assessments of sediment
 quality conditions by:

    •  Presenting an ecosystem-based  framework for assessing  and  managing
       contaminated sediments (Volume I);

    •  Describing the  recommended  procedures for designing  and implementing
       sediment quality investigations (Volume II); and,

    •  Describing the recommended procedures for interpreting the results of sediment
       quality investigations (Volume III).

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                                                                EXECUTIVE SUMMARY - x
 The first volume of the guidance manual, An Ecosystem-Based Framework for Assessing
 andManaging Contaminated Sediments in the Freshwater Ecosystems, describes the five
 step process that is recommended to support the assessment and management of sediment
 quality conditions (i.e., relative to sediment-dwelling organisms, aquatic-dependent wildlife,
 and human health).  Importantly, the document provides an overview of the framework for
 ecosystem-based sediment quality assessment and management (Chapter 2). In addition, the
 recommended procedures for identifying sediment quality issues and concerns and compiling
 the existing knowledge base are  described (Chapter 3).  Furthermore, the recommended
 procedures for establishing ecosystem goals, ecosystem health objectives, and sediment
 management objectives are presented (Chapter 4). Finally, methods for selecting ecosystem
 health indicators, metrics, and targets for assessing contaminated sediments are described
 (Chapter 5).  Together, this guidance is intended to support planning activities related to
 contaminated  sediment assessments, such that the resultant data  are likely to support
 sediment management decisions at the site under investigation. More detailed information
 on these and  other topics related to the assessment and management of contaminated
 sediments can be found in the publications that are listed in the Bibliography of Relevant
 Publications (Appendix 2).

 The second volume  of the series,  Design and Implementation  of Sediment Quality
 Investigations, describes the  recommended procedures  for designing and implementing
 sediment quality assessment programs. More specifically, Volume II provides an overview
 of the recommended framework for assessing and managing sediment quality conditions is
 presented in this document (Chapter 2). In addition, Volume II describes the recommended
 procedures for conducting preliminary and detailed site investigations to assess sediment
 quality conditions (Chapters 3 and 4). Furthermore, the factors that need to be considered
 in the development of sampling and analysis plans for assessing contaminated sediments are
 described (Chapter 5).  Supplemental  guidance  on the  design of sediment  sampling
 programs,  on  the evaluation of sediment quality  data,  and  on  the management  of
 contaminated sediment is provided in the Appendices to Volume II. The appendices of this
 document also describe the types and objectives of sediment quality assessments that are
 commonly conducted in freshwater ecosystems.

 The third volume in the series, Interpretation of the Results of Sediment Quality
 Investigations, describes the four types of information that are commonly used to assess
 contaminated  sediments, including sediment and pore-water chemistry  data (Chapter 2),
 sediment toxicity data (Chapter 3), benthic invertebrate community structure data (Chapter
 4), and bioaccumulation data (Chapter 5).  Some  of the other tools that can be used to
 support assessments of sediment quality conditions are also briefly described (e.g., fish

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                                                                  EXECUTIVE SUMMARY - xi
 health assessments; Chapter 6).  The information compiled on each of the tools includes:
 descriptions of its applications, advantages, and limitations; discussions on the availability
 of standard methods, the evaluation of data quality, methodological uncertainty, and the
 interpretation of associated data; and, recommendations to guide the use of each of these
 individual indicators of sediment quality conditions. Furthermore, guidance is provided on
 the interpretation of data on multiple indicators of sediment quality conditions (Chapter 7).
 Together, the information provided in the three-volume series is intended to further support
 the design and implementation of focused sediment quality assessment programs.
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                                                                     LIST OF ACRONYMS - xii
List of Acronyms
      0,
       0
      ng
      |imol/g
      AET
      AETA
      Al
      ANOVA
      AOC
      APHA
      ARCS Program
      ASTM
      AVS
      BCE
      BCWMA
      BEST
      BSAF
      CA
      CAC
      CCME
      CCREM
      CDF
      CEPA
      CERCLA

      CERCLIS

      CI
      CLP
      COC
      COPC
      CRLD
      CSO
      CSR
      CWA
      -d
      DDT
      DDTs

      DELT
      DL
percent
microgram
micrograms per kilogram
micrograms per liter
micromoles per gram
apparent effects threshold
Apparent Effects Threshold Approach
aluminum
analysis of variance
Area of Concern
American Public Health Association
Assessment and Remediation of Contaminated Sediments Program
American Society for Testing and Materials
acid volatile sulfides
British Columbia Environment
British Columbia Waste Management Act
biomonitoring of environmental status and trends
biota-sediment bioaccumulation factor
Consensus Approach
Citizens Advisory Committee
Canadian Council of Ministers of the Environment
Canadian Council of Resource and Environment Ministers
confined disposal facility
Canadian Environmental Protection Act
Comprehensive Environmental Response, Compensation, and Liability
Act
Comprehensive Environmental Response, Compensation, and Liability
Information System
confidence interval
Contract Laboratory Program
contaminant of concern
chemical of potential concern
contract required detection limit
combined sewer overflow
Contaminated Sites Regulation
Clean Water Act
-days
di chl orodipheny 1-tri chl oroethane
/\p'-DDT, o,/y-DDT,/\p'-DDE, o,//-DDE,/\p'-DDD, 0.//-DDD, and any
metabolite or degradation product
deformities, fin erosion, lesions, and tumors
detection limit
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                                                                 LIST OF ACRONYMS - xiii
 DM             dredged material
 DO             dissolved oxygen
 DOE            Department of the Environment
 DOT             Department of the Interior
 DQO            data quality objective
 DSI             detailed site investigation
 DW             dry weight
 EC             Environment Canada
 EC50            median effective concentration affecting 50 percent of the test organisms
 EEC            European Economic Community
 ELA            Effects Level Approach
 EMAP          Environmental Monitoring and Assessment Program
 EPT             Ephemeroptera,   Plecoptera,  Trichoptera  (i.e.,  mayflies,  stoneflies,
                 caddisflies)
 EqPA           Equilibrium Partitioning Approach
 ERL            effects range low
 ERM            effects range median
 EROD          ethoxyresorufm-0-deethylase
 ESB             equilibrium partitioning-derived sediment benchmarks
 FCV            final chronic values
 FD             factual determinations
 FIFRA          Federal Insecticide, Rodenticide and Fungicide Act
 gamma-BHC     gamma-hexachlorocyclohexane (lindane)
 GFAA          graphite furnace atomic absorption
 GIS             geographic information system
 -h              - hours
 H2S             hydrogen sulfide
 HC             Health Canada
 HC1             hydrochloric acid
 IB I             index of biotic integrity
 IC50             median inhibition concentration affecting 50 percent of test organisms
 ICP             inductively coupled plasma-atomic emission spectrometry
 ID              insufficient data
 IDEM           Indiana Department of Environmental Management
 IJC             International Joint Commission
 IWB            index of well-being
 Koc             organic carbon partition coefficients
 Kow             octanol-water partition coefficients
 Kp             sediment/water partition coefficients
 LC50            median lethal concentration affecting 50 percent of the  test organism
 LCS/LCSDs     laboratory control sample/laboratory control  sample duplicates
 Li              lithium
 LMP            lakewide management plan
 LOD            limit of detection
 LOEC           lowest observed effect concentration
 LRMA          Logistic Regression Modeling Approach

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                                                                LIST OF ACRONYMS - xiv
 mean PEC-Q
 MESL
 MET
 mg/kg
 mg/L
 mlBI
 -min
 mm
 MPRSA
 MS/MSDs
 MSD
 n
 NAWQA
 NEPA
 NG
 NH3
 NH4+
 NOAA
 NOEC
 NPDES
 NPL
 NPO
 NR
 NRDAR
 NSQS
 NSTP
 NT
 NYSDEC
 OC
 OC pesticides
 OECD
 OEPA
 OERR
 OPA
 OPTTS
 OSW
 OW
 PAET
 PAHs
 PARCC
 PCBs
 PCDDs
 PCDFs
 PCS
 PEC
 PEC-Q
mean probable effect concentration quotient
MacDonald Environmental Sciences Ltd.
minimal effect threshold
milligrams per kilogram
milligrams per liter
macroinvertebrate index of biotic integrity
- minutes
millimeter
Marine Protection, Research, and Sanctuaries Act
matrix spike/matrix spike duplicates
minimum significant difference
number of samples
National Water Quality Assessment
National Environmental Policy Act
no guideline available
unionized ammonia
ionized ammonia
National Oceanic and Atmospheric Administration
no observed effect concentration
National Pollutant Discharge and Elimination System
National Priorities List
nonpolar organics
not reported
natural resource damage assessment and restoration
National Sediment Quality Survey
National Status and Trends Program
not toxic
New York State Department of Environmental Conservation
organic carbon
organochlorine pesticides
Organization of Economic Cooperation and Development
Ohio Environmental Protection Agency
Office of Emergency and Remedial Response
Oil Pollution Act
Office of Prevention, Pesticides, and Toxic Substances
Office of Solid Waste
The Office of Water
probable apparent effects threshold
polycyclic aromatic hydrocarbons
precision, accuracy, representativeness, completeness, and comparability
polychlorinated biphenyls
polychlorinated dibenzo-^-dioxins
polychlorinated dibenzofurans
permit compliance system
probable effect concentration (consensus-based)
probable effect concentration quotient
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                                                                 LIST OF ACRONYMS - xv
 PEL           probable effect level
 PEL-HA28     probable effect level for Hyalella azteca; 28-day test
 PQL           protection quantification limit
 PRGs          preliminary remedial goals
 PSDDA        Puget Sound Dredged Disposal Analysis
 PSEP          Puget Sound Estuary Program
 PSI            preliminary site investigation
 QA/QC         quality assurance/quality control
 QAPP          quality assurance project plan
 QHEI          qualitative habitat evaluation index
 RAP           remedial action plan
 RCRA         Resource Conservation and Recovery Act
 REF           reference sediment
 RPD           relative percent difference
 RRH           rapidly rendered harmless
 RSD           relative standard deviation
 SAB           Science Advisory Board
 SAG           Science Advisory Group
 SAP           sampling and analysis plan
 SEC           sediment effect concentration
 SEL           severe effect level
 SEM           simultaneously extracted metals
 SEM - AVS     simultaneously extracted metal minus acid volatile sulfides
 SET AC         Society of Environmental Toxicology and Chemistry
 SLCA          Screening Level Concentration Approach
 SMS           sediment management standards
 SOD           sediment oxygen demand
 SPMD         semipermeable membrane device
 SQAL          sediment quality advisory levels
 SQC           sediment quality criteria
 SQG           sediment quality guideline
 SQRO          sediment quality remediation objectives
 SQS           sediment quality standard
 SSLC          species  screening level concentration
 SSZ           sediment sampling zone
 STP           sewage treatment plant
 SVOC          semi-volatile organic chemical
 T              toxic
 TEC           threshold effect concentration
 TEL           threshold effect level
 TEL-HA28     threshold effect level for Hyalella azteca; 28 day test
 TET           toxic effect threshold
 TIE            toxicity identification evaluation
 TMDL         total maximum daily load
 TOC           total organic carbon
 tPAH          total polycyclic aromatic hydrocarbons

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                                                                 LIST OF ACRONYMS - xvi
 TRA
 TRG
 TRY
 TSCA
 USAGE
 USDOI
 USEPA
 USFWS
 USGS
 VOC
 WDOE
 WMA
 WQC
 WQS
 WW
Tissue Residue Approach
tissue residue guideline
toxicity reference values
Toxic Substances Control Act
United States Army Corps of Engineers
United States Department of the Interior
United States Environmental Protection Agency
United States Fish and Wildlife Service
United States Geological Survey
volatile organic compound
Washington Department of Ecology
Waste Management Act
water quality  criteria
water quality  standards
wet weight
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                                                                       GLOSSARY OF TERMS - xvii
Glossary of Terms
      Acute toxicity-The response of an organism to short-term exposure to a chemical substance.
          Lethality is the response that is most commonly measured in acute toxicity tests.

      Acute toxicity threshold- The concentration of a substance above which adverse effects are
          likely to be observed in short-term toxicity tests.

      Altered benthic invertebrate community - An assemblage of benthic invertebrates that has
          characteristics (i.e., mffil score, abundance of EPT taxa) that are outside the normal
          range that has been observed at uncontaminated reference sites.

      Aquatic  ecosystem - All the living and nonliving material interacting within an aquatic
          system (e.g., pond, lake, river, ocean).

      Aquatic  invertebrates  - Animals without backbones that utilize habitats in freshwater,
          estuaries, or marine systems.

      Aquatic organisms - The species that utilize habitats within aquatic ecosystems (e.g., aquatic
          plants, invertebrates, fish, amphibians and reptiles).

      Benthic invertebrate community - The assemblage of various species of sediment-dwelling
          organisms that are found within an aquatic ecosystem.

      Bioaccumulation - The net accumulation of a substance by an organism as a result of uptake
          from all environmental sources.

      Bioaccumulation-based sediment quality guidelines (SQGs) - Sediment quality guidelines
          that are established to protect fish, aquatic-dependent wildlife, and human health against
          effects that are  associated  with  the bioaccumulation  of contaminants in sediment-
          dwelling organisms and subsequent food web transfer.

      Bioaccumulative substances - The chemicals that tend to accumulate in the tissues of aquatic
          and terrestrial organisms.

      Bioavailability - Degree to which a chemical can be absorbed by and/or interact with an
          organism.

      Bioconcentration - The accumulation of a chemical in the tissues of an organism as a result
          of direct exposure to the surrounding medium (e.g., water; i.e., it does not include food
          web transfer).

      Biomagnification - The accumulation of a chemical in the tissues of an organism as a result
          of food web transfer.

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                                                                 GLOSSARY OF TERMS - xviii
 Chemical  benchmark - Guidelines for water  or  sediment quality  which  define the
    concentration of contaminants that are associated with low or high probabilities of
    observing harmful biological effects, depending on the narrative intent.

 Chemical of potential concern - A substance that has the potential to adversely affect surface
    water or biological resources.

 Chronic toxicity - The response of an organism to long-term exposure to a chemical
    substance. Among others, the responses that are often measured in chronic toxicity tests
    include lethality, decreased growth, and impaired reproduction.

 Chronic toxicity threshold- The concentration of a substance above which adverse effects
    are likely to be observed in long-term toxicity tests.

 Congener  - A member of a group of chemicals with similar chemical structures  (e.g.,
    PCDDs generally refers to a group of 75 congeners that consist of two benzene rings
    connected to each other by two oxygen bridges).

 Consensus-based probable effect concentrations  (PECs) - The PECs that were developed
    from published sediment quality guidelines and identify contaminant concentrations
    above which adverse biological effects are likely to occur.

 Consensus-based threshold effect concentrations (TECs) - The TECs that were developed
    from published sediment quality guidelines and identify contaminant concentrations
    below which adverse biological effects are unlikely to occur.

 Contaminants of concern (COC) - The substances that occur in environmental media at
    levels that pose a risk to ecological receptors or human health.

 Contaminated sediment - Sediment that contains chemical  substances at concentrations that
    could potentially harm sediment-dwelling organisms, wildlife, or human health.

 Conventional variables - A number of variables that are commonly measured in water
    and/or sediment quality  assessments,  including water hardness,  conductivity, total
    organic carbon  (TOC), sediment oxygen demand (SOD), unionized ammonia (NH3),
    temperature, dissolved oxygen (DO), pH, alkalinity

 Core sampler - A  device that is used to collect both surficial and sub-surface sediment
    samples by driving a hollow corer into the sediments.

 Degradation - A breakdown of a molecule into smaller molecules or atoms.

 DELT abnormalities - A number of variables that are measured  to  assess fish health,
    including deformities, fin erosion, lesions, and tumors.
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                                                                  GLOSSARY OF TERMS - xix
 Diagenesis - The sum of the physical and chemical changes that take place in sediments
    after its initial deposition (before they become consolidated into rocks, excluding all
    metamorphic changes).

 Discharge - Discharge of oil as defined in Section 31 l(a)(2) o f the Clean Water Act, and
    includes, but is not limited to, any  spilling, leaking, pumping, pouring, emitting,
    emptying, or dumping of oil.

 Ecosystem - All  the living (e.g.,  plants, animals, and humans) and nonliving  (rocks,
    sediments, soil, water, and air) material interacting within a specified location in time and
    space.

 Ecosystem-based management - An approach that integrates the management of natural
    landscapes,  ecological processes, physical and biological components, and  human
    activities to maintain or enhance the integrity of an ecosystem.  This approach places
    equal emphasis on concerns related to the environment, the economy, and the community
    (also called the ecosystem approach).

 Ecosystem goals - Are broad management goals which describe the long-term vision that has
    been established for the ecosystem.

 Ecosystem metrics - Identify quantifiable attributes of the indicators and defines acceptable
    ranges, or targets, for these variables.

 Ecosystem objectives - Are developed for the various components of the ecosystem to clarify
    the scope and intent of the ecosystem goals.  These objectives  should include target
    schedules for being achieved.

 Endpoint - A measured response of a receptor to a stressor. An endpoint can be measured
    in a toxicity test or in a field survey.

 Epibenthic organisms - The organisms that live on the surface of sediments.

 Exposure - Co-occurrence of or contact between a stressor (e.g., chemical substance) and an
    ecological component (e.g., aquatic organism).

 Grab (Dredge)  samplers - A device that is used to collect surficial sediments through a
    scooping mechanism (e.g.  petite ponar dredge).

 Hazardous substance - Hazardous substance as defined in Section 101(14) of CERCLA.

 Index of biotic  integrity (IBI) - A parameter that is used to evaluate the  status  of fish
    communities.  The IBI integrates information  on species composition (i.e., total number
    of species, types of species, percent sensitive species, and percent tolerant species), on
    trophic composition (i.e., percent omnivores,  percent insectivores, and percent pioneer
    species), and on fish condition.

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                                                                   GLOSSARY OF TERMS - xx
 Infaunal organisms - The organisms that live in sediments.

 Injury - A measurable adverse change, either long or short-term, in the chemical or physical
    quality or the viability of a natural resource resulting either directly or indirectly from
    exposure to a discharge of oil or release of a hazardous substance, or exposure to a
    product of reactions  resulting from the discharge to  oil or release  of a hazardous
    substance.  As used in this part, injury encompasses the phrases "injury", "destruction",
    and "loss".  Injury definitions applicable to specific resources are provided in Section
    11.62 of this part (this definition is from the Department of the Interior Natural Resource
    Damage Assessment Regulations).

 Macroinvertebrate index of biotic  integrity  (mlBI) - The mffil  was used  to provide
    information on the overall structure of benthic invertebrate communities.  The scoring
    criteria for this metric includes such variables as number of taxa, percent dominant taxa,
    relative abundance of EPT taxa,  and abundance of chironomids.

 Mean probable effect concentration-quotient (PEC-Q) - A measure of the overall level of
    chemical contamination in a sediment, which is calculated by averaging the individual
    quotients for select chemicals of interest.

 Natural resources - Land, fish,  wildlife, biota, air,  water, ground  water, drinking water
    supplies,  and other such  resources belonging  to, managed by, held in  trust  by,
    appertaining to, or otherwise controlled  by the federal government (including the
    resources of the fishery conservation  zone established by the Magnuson Fishery
    Conservation and Management Act of 1976), State or local government, or any foreign
    government and Indian tribe.  These natural resource have been categorized into the
    following five groups: surface water resources, ground water resources, air resources,
    geologic resources, and biological resources.

 Natural resources damage  assessment and restoration  - The  process of collecting,
    compiling,  and  analyzing  information,  statistics,   or   data  through  prescribed
    methodologies to determine damages for injuries to natural resources as set forth in this
    part.

 Neoplastic - Refers to abnormal new growth.

 Oil- Oil as defined in Section 31 l(a)(l) of the Clean Water Act, of any kind or in any form,
    including, but not limited to, petroleum, fuel oil,  sludge, oil refuse, and oil mixed with
    wastes other that dredged spoil.

 Piscivorus wildlife species - The wildlife species that consume fish as part of all of their
    diets (e.g., herons, kingfishers, otter, osprey, and  mink).

 Population - An aggregate of individual of a species within a specified location in time and
    space.
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                                                                 GLOSSARY OF TERMS - xxi
 Pore water - The water that occupies the spaces between sediment particles.

 Probable effect concentration (PEC) - Concentration of a chemical in sediment above which
    adverse biological effects are likely to occur.

 Probable effect concentration-quotient (PEC-Q) - A PEC-Q is a measure of the level of
    chemical contamination in sediment relative to a sediment quality guideline,  and is
    calculated by dividing the measured concentration of a substance in a sediment sample
    by the corresponding PEC.

 Receptor - A plant or animal that may be exposed to a stressor.

 Release - A release of a hazardous substance as defined in Section 101(22) of CERCLA.

 Sediment - Paniculate material that usually lies below water.

 Sediment-associated contaminants - Contaminants that  are present in sediments, including
    whole sediments or pore water.

 Sediment chemistry data - Information on the concentrations  of chemical substances in
    whole sediments or pore water.

 Sediment-dwelling organisms - The organisms that live in, on, or near bottom sediments,
    including both epibenthic and infaunal species.

 Sediment injury - The presence of conditions that have injured or are sufficient to injure
    sediment-dwelling organisms, wildlife, or human health.

 Sediment quality guideline  - Chemical  benchmark  that is intended to  define  the
    concentration of sediment-associated contaminants that is associated with a high or a low
    probability  of observing  harmful  biological  effects  or unacceptable  levels of
    bioaccumulation, depending on its purpose and narrative intent.

 Sediment quality targets - Chemical or biological benchmarks for assessing the status of
    each metric.

 Simultaneously extracted metals (SEM) - Divalent metals - commonly cadmium, copper,
    lead,  mercury,  nickel, and zinc  - that  form  less soluble sulfides than does iron or
    manganese and are solubilized during the acidification step (0.5m HC1 for 1 hour) used
    in the determination of acid volatile sulfides in sediments.

 Stressor - Physical, chemical, or biological entities that can  induce  adverse effects on
    ecological receptors or human health.
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                                                                 GLOSSARY OF TERMS - xxii
 Surface water resources - The waters of North America, including the sediments suspended
    in water or lying on the bank, bed, or shoreline and sediments in or transported through
    coastal and marine areas. This term does not include ground water or water or sediments
    in ponds, lakes, or reservoirs designed  for waste  treatment  under the Resource
    Conservation and Recovery Act of 1976 (RCRA), 42 U.S.C. 6901-6987 or the Clean
    Water Act, and applicable regulations.

 Threshold effect concentration (TEC) - Concentration of a chemical in sediment below
    which adverse biological effects are unlikely to occur.

 Tissue - A group of cells, along with the associated intercellular substances, which perform
    the same function within a multicellular organism.

 Tissue  residue guideline  (TRG)  - Chemical  benchmark that is  intended  to define the
    concentration of a substance in the tissues offish or invertebrates that will protect fish-
    eating wildlife  against effects that are associated with dietary exposure to hazardous
    substances.

 Trophic level - A portion of the food web at which groups of animals have similar feeding
    strategies.

 Trustee - Any Federal natural resources management agency designated in the National
    Contingency Plan  and any State  agency  designated by the Governor of  each State,
    pursuant to Section 107(f)(2)(B) of CERCLA, that may prosecute claims for damages
    under Section 107(f) or 11 l(b) of CERCLA; or any Indian tribe, that may  commence an
    action under Section 126(d) of CERCLA.

 Wildlife - The fish, reptiles, amphibians, birds, and mammals that are associated with aquatic
    ecosystems.

 Whole sediment - Sediment and associated pore water.
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                                                                        ACKNOWLEDGMENTS - xxiii
Acknowledgments
       The authors would like to acknowledge the efforts of a number of individuals who contributed to the
       preparation of 'A Guidance Manual to Support the Assessment of Contaminated Sediments in
       Freshwater Ecosystems'. First, we would like to thank the members of the Science Advisory Group
       on Sediment Quality Assessment for their insight and guidance on the need for and elements of this
       Guidance Manual.  We  would also like to thank the instructors of the various short courses on
       sediment quality assessment for providing access to  instructional  materials that provided a
       conceptual basis for many of the sections included in the Guidance Manual. Furthermore, we would
       like to express our sincerest appreciation to the members of the project Steering Committee for
       providing oversight and excellent review comments on previous drafts of this report. The Steering
       Committee consisted of the following individuals:

                          Tom Balduf (Ohio Environmental Protection Agency)
                      Walter Berry (United States Environmental Protection Agency)
                   Kelly Burch (Pennsylvania Department of Environmental Protection)
                     Scott Cieniawski (United States Environmental Protection Agency)
                     Demaree Collier (United States Environmental Protection Agency)
                           Judy Crane (Minnesota Pollution Control Agency)
                     William Creal (Michigan Department of Environmental Quality)
                     Bonnie Eleder (United States Environmental Protection Agency)
               Frank  Estabrooks  (New York State Department of Environmental Conservation)
                          John  Estenik (Ohio Environmental Protection Agency)
                      Jay Field (National Oceanic and Atmospheric Administration)
                      Scott Ireland (United States Environmental Protection Agency)
                      Roger Jones (Michigan Department of Environmental Quality)
                    Peter Landrum (National Oceanic and Atmospheric Administration)
                      Lee Liebenstein (Wisconsin Department of Natural Resources)
              Mike Macfarlane (British Columbia Ministry of Water, Land and Air Protection)
                           Jan  Miller  (United States Army Corps of Engineers)
                          T.J.  Miller (United States Fish and Wildlife Service)
                      Dave Mount (United States Environmental Protection Agency)
                  Gail Sloane (Florida Department of Environmental Protection Agency)
                       Eric Stern (United States Environmental Protection Agency)
                     Marc Tuchman (United States Environmental Protection Agency)
               Karen Woodfield  (New York State Department of Environmental Conservation)

       Finally, timely review comments on the final draft of the Guidance Manual were provided by Scott
       Cieniawski, Demaree Collier, Marc Tuchman, Scott Ireland, Bonnie Eleder, Jay Field, Judy Crane,
       and Mike Macfarlane. Development of this Guidance Manual was supported in part by the United
       States Environmental Protection Agency's Great Lakes National Program Office through the grant
       "Development of a Guidance Manual for Sediment Assessment", Grant Number GL995632-01,
       awarded to the  Sustainable Fisheries Foundation. Additional funding to support the preparation of
       this report was provided by the Florida Department of Environmental Protection and the British
       Columbia Ministry of Water, Land and Air Protection. This report has been reviewed in accordance
       with United States Environmental Protection Agency, United States Geological Survey,  and
       Sustainable Fisheries Foundation policies.
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                                                                    INTRODUCTION - PAGE 1
Chapter 1.    Introduction
1.0  Background
      In response to concerns that have been raised regarding contaminated sediments, a number
      of programs have been established or expanded to support the assessment and management
      of contaminated sediments in the United States and Canada (Appendix 1 of Volume III). The
      information generated under these programs provides important guidance for designing and
      implementing investigations at sites  with contaminated sediments (see USEPA 1994;
      MacDonald 1994a; 1994b; Reynoldson et al. 2000; Ingersoll et al. 1997; USEPA and
      USAGE  1998a; ASTM 2001a; USEPA 2000a; Krantzberg et al. 2001).  While these
      guidance documents have unquestionably advanced the field of sediment quality assessment,
      the users of these individual guidance documents have expressed a need to consolidate this
      information into  an integrated ecosystem-based framework for assessing and managing
      sediment quality in freshwater ecosystems.

      This guidance manual, which comprises a three-volume series and was  developed for the
      United States Environmental Protection Agency, British Columbia Ministry of Water, Land
      and Air Protection, and Florida Department of Environmental Protection, is not intended to
      supplant the existing guidance documents on sediment quality assessment (e.g., USEPA
      1994; Reynoldson et al. 2000; USEPA and USAGE 1998a; USEPA 2000a; ASTM 200la;
      Krantzberg et al. 2001).  Rather, this  guidance manual is intended to further support the
      design and implementation of assessments of sediment quality conditions by:

         •   Presenting an  ecosystem-based  framework  for  assessing  and  managing
             contaminated sediments (Volume I);

         •   Describing the  recommended  procedures  for  designing and  implementing
             sediment quality investigations (Volume II); and,

         •   Describing the recommended procedures for interpreting the results of sediment
             quality investigations (Volume III).
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                                                                INTRODUCTION - PAGE 2
 The first volume of the guidance manual, An Ecosystem-Based Framework for Assessing
 andManaging Contaminated Sediments in Freshwater Ecosystems, describes the five step
 process that is recommended to support the assessment and management of sediment quality
 conditions (i.e., relative to sediment-dwelling organisms, aquatic-dependent wildlife, and
 human health).  Importantly, the document provides an overview of the framework for
 ecosystem-based  sediment  quality assessment and  management  (Chapter  2).   The
 recommended procedures for identifying sediment quality issues and concerns and compiling
 the existing knowledge  base are described (Chapter 3).  Furthermore, the recommended
 procedures for establishing ecosystem goals, ecosystem health objectives,  and sediment
 management objectives are presented (Chapter 4). Finally, methods for selecting ecosystem
 health indicators, metrics, and targets for assessing contaminated  sediments are described
 (Chapter 5).  Together, this guidance is intended to support planning activities related to
 contaminated sediment  assessments, such that the resultant data are likely to support
 sediment management decisions at the site under investigation. More detailed information
 on these and other topics related to the assessment and  management of contaminated
 sediments can be found  in the publications that are listed in the Bibliography of Relevant
 Publications  (Appendix  2 in Volume I).

 The second  volume of the series, Design and Implementation of Sediment Quality
 Investigations., describes the recommended procedures  for designing and implementing
 sediment quality assessment programs. More specifically, an overview of the recommended
 framework for assessing and managing sediment quality conditions is presented in this
 document (Chapter 2). In addition, Volume II describes  the recommended procedures for
 conducting preliminary and detailed site investigations to assess sediment quality conditions
 (Chapters 3 and 4). Furthermore, the factors that need to be considered in the development
 of sampling and analysis plans for assessing contaminated sediments are described (Chapter
 5). Supplemental guidance on the design of sediment sampling programs, on the evaluation
 of sediment quality data, and on the management of contaminated sediment is provided in
 the Appendices to Volume n.  The appendices of this document also describe the types and
 objectives  of sediment quality assessments that are commonly conducted in freshwater
 ecosystems.
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                                                                  INTRODUCTION - PAGE 3
 The third volume in the series,  Interpretation of the Results of Sediment  Quality
 Investigations,  describes the four types of indicators  that are commonly used to assess
 contaminated sediments, including sediment and pore-water chemistry data (Chapter 2),
 sediment toxicity data (Chapter 3), benthic invertebrate community structure data (Chapter
 4), and bioaccumulation data (Chapter 5). Some of the other indicators that can be used to
 support assessments of sediment  quality conditions are also  described (e.g.,  fish health
 assessments; Chapter 6).  The information compiled on each of the indicators includes:
 descriptions of its applications, advantages, and limitations; discussions on the  availability
 of standard methods, the evaluation of data quality, methodological uncertainty,  and the
 interpretation of associated  data;  and, recommendations to guide its use.  Furthermore,
 guidance is provided on the interpretation of data on multiple indicators of sediment quality
 conditions (Chapter 7).  Together, the information provided in the three-volume  series is
 intended to further  support the design and implementation of focused sediment quality
 assessment programs.
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                                    ASSESSMENT OF WHOLE-SEDIMENT AND PORE-WATER CHEMISTRY - PAGE 4
Chapter 2.    Assessment of Whole-Sediment  and Pore-
                   Water Chemistry


2.0  Introduction

      Sediment chemistry data represent a fundamental element of sediment quality assessments
      that are focused on  evaluation of the  effects of toxic and bioaccumulative substances.
      Therefore, sediment chemistry is routinely selected as one of the key ecosystem health
      indicators in most sediment quality investigations (see Volume I for information on the
      selection of the ecosystem health indicators).  To be effective, however, metrics and
      associated targets must be selected that are relevant to the site under investigation (i.e.,
      relative to the management objectives established; see Chapters 4 and 5 of Volume I).  In
      general, the metrics that are selected for evaluating sediment chemistry typically include the
      concentrations of the chemicals of potential concern (COPCs) that have been identified for
      the site.  Sediment quality targets are usually identified  by selecting sediment quality
      guidelines (SQGs) that apply to the receptors of concern and desired level of protection at
      the site. This chapter is intended to provide guidance on the selection of metrics and targets
      for sediment chemistry that will provide the information needed to effectively assess
      sediment quality conditions at contaminated sites.  A description of the recommended uses
      of SQGs is provided in Appendix 1 of Volume III.
2.1  Selection of Metrics and Targets for Sediment Chemistry

      Several types of information can be used to support the selection of appropriate metrics for
      sediment chemistry.  First, current and historic land and water use activities in the vicinity
      of the  site should be determined (see Volume II for more information).  Historical data
      should include information on the nature and location of industrial developments (and
      associated management practices that could lead to releases of chemical substances) and
      municipal infrastructure (combined sewer overflows, sewage treatment plants), on the nature

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                                ASSESSMENT OF WHOLE-SEDIMENT AND PORE-WATER CHEMISTRY - PAGES
 and location of any spills that have occurred, and on the nature and general location of non-
 point pollution sources. In addition, information on the location, composition, and volumes
 of storm water and effluent discharges is useful for identifying the chemicals that have been
 or may have been released into surface waters near the site. Evaluation of the environmental
 fate of these chemicals provides a basis for identifying the substances that are likely to
 partition into sediments. Finally, existing sediment chemistry data should be assembled and
 used to identify the chemicals that have been measured at elevated levels (i.e., compared to
 SQGs) in surficial (i.e., top 10 cm) and deeper sediments. Together, this information can be
 used to develop a list of COPCs for the site. This list of COPCs can then be used to establish
 the primary metrics for sediment chemistry at the site.  Additional metrics, such as total
 organic carbon (TOC), grain size, acid  volatile sulfides (AVS),  ammonia, and hydrogen
 sulfide should also be included to support interpretation of the resultant data for the primary
 metrics.   The final list of chemical  analytes  to be measured is also influenced by the
 equipment, technology, facilities, and funds that are available for the project (see Chapter 3
 of Volume I for more information on the identification of COPCs).

 The chemicals  that are typically  analyzed in whole-sediment samples  collected near
 urbanized and industrial  areas include trace  metals,  polycyclic aromatic  hydrocarbons
 (PAHs), polychlorinated biphenyls (PCBs), and several other organic constituents [e.g.,
 polychlorinated dibenzo-p-dioxins and  polychlorinated dibenzofurans (PCDDs/PCDFs);
 chlorophenols, and phthalates].  In areas that may be affected by inputs from  agricultural
 activities,  it may be appropriate  to measure  the concentrations of pesticides [such as
 organochlorines (OCs), carbamates, and organophosphates] in sediment samples. Chemical
 concentrations are generally  reported on a dry weight basis, based on the results of total
 extraction of sediment samples.  However, several other measures of sediment chemistry
 have also been utilized in various assessments. For example, the concentrations of non-ionic
 organic contaminants may be normalized to TOC concentrations in sediment (Swartz et al.
 1987; Di Toro et al.  1991).  In addition, AVS-normalization procedures may be used to
 interpret data on the levels of simultaneously extracted metals (SEMs; Di Toro et al.  1992;
 Ankley et al.  1996).  Furthermore, chemical concentrations can be normalized to percent
 fines.  These normalization procedures are intended to better define the bioavailable fraction
 of the substance under consideration.

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                                ASSESSMENT OF WHOLE-SEDIMENT AND PORE-WATER CHEMISTRY - PAGE 6
 Pore water is the water that occupies the spaces between sediment particles. Pore water can
 be isolated from the sediment matrix  to  conduct toxicity testing or  to  measure the
 concentrations of chemical substances.  ASTM (200la) and USEPA (2000a)  describe
 procedures  for  isolating pore water from  whole-sediment  samples.  Evaluation of the
 concentrations of COPCs in pore water is important because sediment-dwelling organisms
 are directly exposed to the substances that occur in this sediment phase. For this reason, pore
 water assessments can provide useful information on the potential effects  of sediment-
 associated contaminants, particularly on infaunal  species (i.e., those species that utilize
 habitats within  the sediment matrix).  Importantly, the toxicity of sediments to aquatic
 organisms has been correlated to the concentrations of COPCs in pore water (Di Toro et al.
 1991; Ankley et al. 1996).  COPCs in pore water also represent hazards to water column
 species because these substances can be transported into overlying waters through chemical
 partitioning, diffusion, bioturbation, or  resuspension processes.  However, data on the
 concentrations of chemicals in pore water may not fully represent the total exposure of
 sediment-dwelling  organisms  to  sediment-associated  contaminants,   particularly  for
 compounds with higher octanol-water partition coefficients (Kows) that bind strongly to
 organic carbon in the sediment (Harkey et al. 1994). For this reason, pore-water chemistry
 alone should not be used to evaluate total exposure to  sediment-associated COPCs.

 Selection of appropriate metrics for pore-water chemistry should be done  in a manner that
 is consistent with the process used to select the metrics for whole-sediment chemistry.  In
 addition to the substances that are expected to partition into sediments (due to their physical-
 chemical properties), it may be appropriate to include additional COPCs that are likely to
 partition primarily into water.  It is necessary  to include a number of variables (e.g., pH,
 water temperature, water hardness, dissolved oxygen) that will provide ancillary information
 for interpreting the data on the primary chemical metrics.

 Sediment chemistry data provide information that is  directly relevant for determining if
 sediments within an assessment area are contaminated with toxic and/or bioaccumulative
 substances.  However, information on the concentrations of contaminants in whole sediments
 (i.e., the metrics for sediment chemistry) does not, by itself, provide a basis for determining
 if the ecosystem goals and objectives are being achieved.  For this reason, it is necessary to
 establish sediment quality targets for sediment chemistry that define the levels of each metric
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 (i.e., the COPCs and mixtures of COPCs) that are likely to support the designated uses of the
 aquatic ecosystem (i.e., the benthic  invertebrate  community).   These targets can be
 established by selecting appropriate SQGs for each COPC at the site.  Such SQGs can be
 derived using information on contemporary background levels and/or on the concentrations
 associated with a pre-selected probability of observing adverse biological effects (e.g., Field
 et al. 2002; Appendices 2 and 3 of Volume III).

 Effects-based SQGs represent the a tool that can be used to help establish sediment quality
 targets that correspond to the specific management goals that have been established for the
 site under consideration. A variety of numerical SQGs have been developed to support
 sediment quality assessments in North America (Tables 1 and 2; Appendix 3 of Volume HI).
 The approaches selected by individual jurisdictions depend on the receptors that are to be
 considered (e.g., sediment-dwelling organisms, wildlife, or humans), the degree of protection
 that is to be afforded, the geographic area to which the values are intended to apply (e.g., site-
 specific, regional, or national), and their intended uses (e.g., screening tools, remediation
 objectives, identifying toxic and not toxic samples, bioaccumulation  assessment). While
 such SQGs can be used in many applications, USEPA generally advocates their use primarily
 in screening level assessments of sediment quality conditions (B. Eleder. United  States
 Environmental Protection Agency. Chicago, Illinois. Personal communication).

 Guidelines for assessing sediment quality relative to the potential for adverse effects on
 sediment-dwelling organisms in freshwater systems have been derived using a combination
 of theoretical and empirical approaches, primarily including the equilibrium partitioning
 approach [(EqPA) which is used to develop equilibrium  partitioning-derived sediment
 benchmarks (ESBs); Di Toro et al. 1991; NYSDEC 1999; USEPA 1997], screening level
 concentration approach (SLCA; Persaud etal. 1993), effects range approach (ERA; Long and
 Morgan 1991; USEPA 1996), effects level approach (EL A; Smhhetal. 1996; USEPA 1996),
 the apparent effects threshold approach (AETA; Cubbage etal. 1997),  the consensus-based
 approach (Swartz 1999; MacDonald et al. 2000a; 2000b; 2002a; 2002b; USEPA 2000b;
 Ingersoll et al. 2001; 2002), and the logistic regression modeling approach (LRM; Field et
 al. 1999; 2000). Application of these methods has resulted in the derivation of numerical
 SQGs for many COPCs in freshwater sediments (Tables 1 and 2; Appendix 3 of Volume HI).

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 In addition to causing direct effects on aquatic biota (Chapters 3 and 4 of Volume HI),
 sediment-associated COPCs can accumulate in the tissues of sediment-dwelling organisms
 (Chapter 5 of Volume III). Because many benthic and epibenthic species represent important
 components of the food web, such contaminants can be transferred to higher trophic levels
 in the food web.  In this way, contaminated sediments represent a potential hazard to the
 wildlife species that consume aquatic organisms.  As such, sediment chemistry represents
 an important ecosystem health indicator with respect to the potential for effects on aquatic-
 dependent wildlife species.

 The concentrations of bioaccumulative substances in sediments represent the primary metrics
 for assessing sediment chemistry relative to aquatic-dependent wildlife (Chapter 5 of Volume
 III). In general, the target analytes in whole sediments should be selected based on historic
 information on water and land uses in the vicinity of the site under investigation, as well as
 a review of existing sediment and tissue chemistry data.  The bioaccumulative substances
 that are commonly measured in whole-sediment samples collected in the vicinity of urban,
 industrial, and agricultural areas include certain PAHs, PCBs, OC pesticides, chlorophenols,
 certain trace metals (e.g., mercury), and PCDDs/PCDFs (ASTM 2001a; USEPA 2000a).

 Residue-based SQGs provide practical tools for establishing targets for sediment chemistry
 relative to the potential for bioaccumulation (Cook et al. 1992; Appendix 3 of Volume HI).
 Residue-based SQGs define the maximum concentrations of individual chemicals or classes
 of chemicals in sediments that are predicted to result in tolerable levels of those substances
 in the tissues of aquatic organisms (i.e., below the levels associated with adverse effects in
 piscivorus wildlife). The first step in the development of residue-based SQGs involves the
 derivation or selection of an appropriate tissue residue guideline (TRG) for the substance or
 substances under consideration (e.g., the New York  State Department of Environmental
 Conservation fish flesh criteria for piscivorus wildlife; Newell et al. 1987). Subsequently,
 relationships between concentrations of COPCs in sediments and COPC residues in aquatic
 biota needs to be established.  In general, the necessary biota-sediment accumulation factors
 (BSAFs) are determined from field studies, based on the results of bioaccumulation tests,
 and/or estimated using various modeling approaches. The SQGs are then derived by dividing
 the  TRG by the  BSAF  (Cook et al. 1992; NYSDEC  1999). Because  it is difficult to
 accurately predict relationships between sediment chemistry  and  the concentrations of
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      COPCs in the tissues of aquatic organisms, potential risks of piscivorus wildlife identified
      using the SQGs should be confirmed using site-specific tissue residue data and appropriate
      TRGs.

      Contaminated sediment represents a significant environmental concern with respect to the
      protection of human health. Humans can be directly exposed to contaminated sediments
      through primary contact recreation, including swimming and wading in affected waterbodies.
      In addition, indirect exposures to sediment-associated contaminants can occur when human
      consume fish,  shellfish,  or wildlife  tissues that  have become contaminated  due  to
      bioaccumulation in the food web (Crane 1996). Therefore, sediment chemistry represents
      an important ecosystem health indicator for assessing the potential effects of COPCs on
      human health.  The bioaccumulation-based SQGs for the protection of human health that
      were developed by New York State Department of Environmental Conservation (NYSDEC
      1999) and Washington State Department of Health  (1995;  1996) provide  a basis for
      establishing sediment quality targets relative to the protection of human health.
2.2  Availability of Standard Methods
       Standard methods have been developed to support the characterization of whole-sediment
       or pore-water samples for most major COPCs (i.e., by American Society for Testing and
       Materials (ASTM), United States Environmental Protection Agency (USEPA), Organization
       for Economic Cooperation and Development, Environment Canada; Appendix 4 of Volume
       III).  In addition, methods used to develop and evaluate SQGs have been described in the
       peer-reviewed literature (Appendix 3 of Volume III).
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2.3   Advantages and Disadvantages of Sediment Chemistry Data

       One of the principal strengths of using sediment chemistry data for whole sediments in
       assessing the potential effects on sediment-dwelling organisms is that it provides direct
       information on the presence  and concentrations  of COPCs in  sediments (Table 3).  In
       addition, standard methods have been established for determining the concentrations of many
       analytes in whole-sediment samples. Because measurements of sediment chemistry can be
       both  accurate and precise,  they provide a reliable basis for discriminating  between
       contaminated  and uncontaminated  sites.  Furthermore, analytical  methods have  been
       developed that may provide information on the potential bioavailability of certain substances
       (e.g., SEM minus AVS and organic carbon normalization of non-ionic organic compounds).
       Importantly, reliable SQGs have been developed for many COPCs, which provide a basis of
       interpreting sediment chemistry data relative to the potential for effects on sediment-dwelling
       organisms.

       One of the main limitations of sediment chemistry data is that, by itself, it can not provide
       a basis for assessing the potential effects of contaminated sediments. The utility of these data
       may also be limited by the suite of analytes and detection limits selected for determination.
       For example, important chemicals may be missed if the available land and water use data are
       not collected and appropriately interpreted (e.g., PCDDs /PCDFs should be measured in the
       vicinity of pulp mills, pesticides should be measured near agricultural areas). In some cases,
       the utility of these data is also limited by the inappropriate use of analytical methods (i.e.,
       which do not support achievement of target detection limits) or by  inadequate quality
       assurance practices (i.e., such that evaluating the reliability of the data is not possible).

       One of the strengths of pore-water chemistry data is that it provides information on the levels
       of COPCs in this important exposure medium (Table 3). As such, pore-water chemistry data
       facilitates the identification of the substances that are causing or substantially contributing
       to  any adverse biological effects that are observed.  As is the  case for whole-sediment
       chemistry, standard methods have been established for determining the concentrations of
       many COPCs in pore water. Importantly, measurements of the concentrations of COPCs in
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 pore water provide direct information on the sediment-associated contaminant fraction that
 is likely to be most available to sediment-dwelling organisms.

 Pore-water chemistry data also have a number of limitations that restrict their application in
 sediment quality assessments. First, pore-water chemistry data cannot be used alone to
 evaluate the potential for effects on sediment-dwelling organisms (i.e., companion tools are
 needed to link contaminant concentrations to the effects on various receptors). Second, the
 procedures that are used to obtain pore water from whole sediments have the potential to
 alter pore-water chemistry.  Third, obtaining sufficient volumes of pore water to support
 analysis of a full suite of chemical analytes (or toxicity testing) is often difficult, particularly
 when low detection limits are required to assess risks associated with exposures of sediment-
 dwelling organisms to organic contaminants. Pore-water chemistry can also vary temporally
 (e.g., seasonally).  Finally, the utility of these data can be difficult to evaluate due to use of
 inappropriate methods  or inadequate quality assurance practices (ASTM  200la; USEPA
 2000a).  Measuring water  quality characteristics of the pore water to  assist  in the
 interpretation of these  data is important (i.e., hardness,  alkalinity, pH, dissolved organic
 carbon).

 Interpretation of sediment chemistry data relative to the potential for effects on wildlife
 species is complicated by differences in BSAFs and food web transfer rates among sites. As
 such, predictions of COPC accumulation rates from sediment to biota should generally be
 validated using appropriate field  and/or laboratory procedures.   Residue-based SQGs
 represent important tools for conducting sediment quality assessments for  several reasons.
 First and foremost, residue-based SQGs explicitly consider the potential for bioaccumulation
 and effects on higher trophic levels. In addition, the residue-based SQGs provide a basis for
 interpreting sediment chemistry data in terms of the potential for adverse effects on wildlife.
 Such  assessments  should  be  supported  by  direct  measurements of  contaminant
 concentrations in  the tissues of aquatic organisms and wildlife species to assure that the
 actual risks to ecological receptors are appropriately evaluated (Chapter 5 of Volume III).

 One of the disadvantages of utilizing sediment quality as  an indicator of effects on wildlife
 is that TRGs for the protection of wildlife have not been developed for many COPCs (Newell

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       et al. 1987; Cook et al. 1992). Therefore, SQGs for such COPCs must be developed before
       effects on aquatic-dependent wildlife can be assessed using sediment chemistry data.

       When considered in conjunction with food web models, sediment chemistry data can be used
       to predict the concentrations of COPCs in fish, shellfish, and wildlife tissues; hence, it is
       possible to  evaluate  various  human  health exposure  scenarios  associated  with  the
       consumption of contaminated tissues.  The availability of standard analytical methods,
       procedures for assessing data  quality  (i.e., accuracy, precision, detection  limits), and
       procedures for evaluating the bioavailability of sediment-associated COPCs make sediment
       chemistry a reliable indicator of sediment quality conditions.

       In spite of the advantages noted above, interpretation of sediment chemistry data relative to
       the potential for  effects on human health poses a challenge for several reasons.  First,
       sediment chemistry data, alone, cannot be used to evaluate the potential for effects on human
       health. Interpretation of such data relative to human health necessarily requires effects-based
       SQGs. Relative to direct contact recreation, derivation of such  guidelines necessitates the
       development of exposure scenarios that are relevant to the site under investigation (i.e., in
       addition to  appropriate  toxicological data).   Second,  estimation  of the  levels  of
       bioaccumulative substances in the tissues offish, shellfish, or wildlife necessitates the use
       of bioaccumulation models, which may or may not be directly applicable to the ecosystem
       under study. Furthermore, the actual exposures of humans to contaminated tissues can be
       reduced through the imposition offish consumption advisories. Therefore, effects on human
       health that are predicted based on sediment chemistry data may not actually be observed in
       the field.
2.4   Evaluation of Data Quality

       The use of performance-based methods has been recommended for sediment toxicity testing
       (ASTM 200la; USEPA 2000a).  Performance-based methods provide investigators with a
       higher degree of confidence that project data quality objectives (DQOs) will be met. This

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       approach is also highly relevant for guiding the generation of sediment chemistry data. In
       this context, performance standards should be established for data accuracy, data precision,
       and analyte detection limits. Guidance on the establishment of DQOs and evaluation of data
       quality is provided in Appendix 3 of Volume n. Importantly, target detection limits should
       be established at concentrations lower than  the selected sediment quality target (i.e., below
       a selected SQG). Appendix 4 of Volume III outlines criteria that should be considered when
       evaluating the quality of chemistry data used in an assessment of sediment quality. A quality
       assurance project plan (QAPP) should be developed to describe the experimental design and
       sampling procedures for sediment collection and chemical analyses.
2.5   Methodological Uncertainty
       A review of uncertainty associated with endpoints commonly used in sediment ecological
       risk assessments and approaches for addressing these sources of uncertainty was provided
       by Ingersoll et al. (1997) and Wenning and Ingersoll  (2002).  Endpoints included in this
       evaluation included:  toxicity tests (both the fraction tested and the endpoints selected);
       benthic invertebrate assessments; bioaccumulation assessments; sediment chemistry; and,
       sediment chemistry and SQGs. A series of criteria were established by Ingersoll etal. (1997)
       to  support consistent assessments  of the uncertainty  associated with  each of these
       measurement endpoints. These evaluation criteria included: precision; ecological relevance;
       causality; sensitivity; interferences;  standardization; discrimination; bioavailability; and,
       field validation.

       The results of these evaluations are presented in Table 4 for sediment chemistry and in Table
       5 for SQGs. Uncertainty associated with lack of knowledge is indicated with an asterisk in
       these  tables to  differentiate it  from  systematic uncertainty,  which  can be rectified
       (methodologically) or quantified (sampling decisions and design).
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 2.5.1    Uncertainty Associated with Sediment Chemistry

 The uncertainty  associated with the following measures of sediment chemistry were
 evaluated by Ingersoll et al. (1997; Table 4):

    •  Bulk sediment analysis using total extraction of sediments;

    •  Normalization  of non-ionic organic contaminants to  TOC concentration of
       sediment;
    •  Metal speciation as derived by AVS or by evaluating other partitioning phases;

    •  Concentration of contaminants in pore-water samples;

    •  Concentrations of contaminants in elutriate samples; and,

    •  Concentrations of reference elements (which are regional reference levels to
       which contaminant concentrations are compared).


 The evaluation performed by Ingersoll et al. (1997) addresses the uncertainty associated with
 the use of sediment chemistry alone in sediment assessments. A lower level  of uncertainty
 would be assigned to several of the chemistry measures if these endpoints were used in
 combination with other endpoints (e.g., toxicity tests, benthic community assessments).

 Precision was defined by Ingersoll et al. (1997) in terms of the robustness of the analytical
 method. That is, procedures that generate similar concentrations in repeated analyses of the
 same samples were considered to have a lower level of uncertainty than those that generate
 variable results.  The lowest level of uncertainty was assigned to bulk sediment, TOC-
 normalization,  SEM-AVS  (i.e.,  on a  molar basis), elutriate, and  reference  element
 measurements because a high level of precision can be attained using existing analytical
 methods. Pore-water chemistry and procedures intended to determine the form of a COPC
 present in a sample (speciation procedures) were assigned a higher level of uncertainty,
 primarily resulting from the lack of routine methods used in these analyses.  Ecological
 relevance was evaluated in terms of linkages to receptors that are to be protected.  In this

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 respect, bulk sediment chemistry, elutriates, and reference element measurements were rated
 low since these approaches are not based on measures of bioavailability or are not direct
 measures of ecological relevance.  Total organic carbon normalization, SEM-AVS, metal
 speciation, and pore-water measures were rated as having a moderate level of uncertainty
 since these measures are based on the principle of evaluating the bioavailable fraction of a
 chemical in sediment.

 Determination of causality (i.e., correctly identifying stressors) was evaluated in terms of the
 ability of various indicators to determine specific linkages to a COPC, to COPC mixtures,
 or to sources of COPCs.  Low uncertainty was assigned to all of the measures of sediment
 chemistry, except those which determined chemical concentrations in sediment elutriates.
 Preparation of elutriates alters  the sediment sample, increasing the uncertainty in the
 sediment contaminant concentration.  Although pore-water concentrations provide more
 direct linkages to bulk sediment chemistry, the procedures used to isolate pore water may
 also introduce considerable uncertainty.  Bulk sediment chemistry and reference element-
 based procedures were considered to provide useful measures for evaluating COPC sources,
 particularly for certain classes of organics (e.g., PAHs) and for metals. In contrast, elutriate
 chemistry provides limited information regarding the chemical composition of sediments in
 situ or COPC sources.

 Sensitivity is important because there is a need to reliably identify sediments with high,
 moderate, and low concentrations of COPCs (i.e., as compared to SQGs). Most analytical
 methods  for determining  chemical concentrations  in  sediments  are  very sensitive.
 Interferences are  considered to be factors  which  impair accurate  determination  or
 interpretation  of the concentrations  of COPCs  in sediment samples.  In most cases,
 interferences are related  to sample matrix problems and are analyte specific in any of the
 categories listed in Table 4.  Interpretation interferences include particle size variability and
 anomalously high concentrations of natural  sediment  components which equilibrate with
 high concentrations  of COPCs.

 Standard methods have been developed for virtually all of the analytical procedures outlined
 in Table 4 (e.g., bulk sediment chemistry, pore-water chemistry, TOC). However, there are
 still few methods available which can effectively speciate metals and metalloids in oxidized
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 sediments or can be used to measure non-priority pollutants. Analytical methods are very
 good discriminators (i.e., establish a gradient) among samples. However, the interpretational
 uncertainties described above for bulk sediments add substantial uncertainties relative to the
 discrimination of contamination using this method.  Although whole-sediment COPC
 concentrations do not explicitly intend to quantify the bioavailable fraction, they have been
 shown to be predictive of biological responses (Ingersoll etal. 2001; 2002). The TOC- and
 AVS-normalization procedures are intended to reduce the level of uncertainty about the
 bioavailability of non-ionic organics and metals, respectively; however, these procedures
 have not been shown to increase predictive ability for mixtures of COPCs in field-collected
 sediments beyond that which has been achieved using dry-weight whole-sediment chemistry
 data (Long etal. 1998a; Field etal. 1999; 2002; USEPA2000b). Elutriate preparation tends
 to alter bioavailability in unpredictable ways and, therefore, increases uncertainty.

 Field validation was interpreted by Ingersoll et al. (1997) in terms of the accuracy of the
 method.  That is,  the uncertainty about the extent to which measurements of sediment
 chemistry reflect actual field concentrations of contaminants was evaluated. Bulk sediment
 chemistry and reference element concentrations have low uncertainty  with respect to
 accuracy because these methods have well-established quality assurance and quality control
 procedures. A number of uncertainties are associated with the analysis of inorganics (i.e.,
 AVS or metal speciation)  and with elutriates (e.g., alterations of the sediments which
 organisms are exposed to  in situ, resulting from sample collection, storage, laboratory
 treatment or other methodological procedures).
 2.5.2    Uncertainties Associated with Uses of Sediment Quality
           Guidelines

 In their evaluation of uncertainty, Ingersoll et al. (1997) grouped SQGs into seven categories
 (Table 5):

    •  Equilibrium partitioning-derived sediment benchmarks (ESBs);
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    •  Effects range low (ERLs) and effects range median (ERMs; threshold  and
       probable effect levels (TELs and PELs) were considered to be functionally
       similar to the ERLs and ERMs);

    •  Apparent effects thresholds (AETs);

    •  Screening level concentrations (SLCs);

    •  Simultaneously extracted metals minus acid volatile sulfide (SEM-AVS);

    •  Toxic units models; and,

    •  Residue-based SQGs (Appendix 3 of Volume III).


 Consensus-based SQGs or LRM-based SQGs had not been developed or evaluated at the
 time that the Ingersoll et al. (1997) study was conducted (Swartz 1999; MacDonald et al.
 2000a; 2000b; 2002a; 2002b; USEPA2000a; Ingersoll etal. 2001; 2002; Field et al. 1999;
 2002).

 Precision was evaluated by Ingersoll et al. (1997) as a measure of the applicability of the
 SQGs across geographic areas. In terms of precision, the lowest level of uncertainty was
 assigned to the ESBs because of the extensive toxicology database on which they were
 derived. Higher uncertainty was assigned to AETs and SLCs because of the site-specificity
 associated with their derivation. A moderate level of uncertainty was also assigned to the
 SEM-AVS based guidelines because of the micro-spatial distribution of AVS. Ecological
 relevance was evaluated in terms of its linkage to the receptors that are to be protected.
 Guidelines which directly consider mixtures were assigned a relatively low level of
 uncertainty (ESB mixture models, SEM-AVS guidelines, and the ERL/ERM guidelines
 derived using data from the field which included contaminant mixtures). Individual ESB
 values do not consider the effects of mixtures of COPCs and,  hence, were assigned a
 moderate  level  of uncertainty.   Similarly, AETs  were assigned  a moderate level of
 uncertainty because of their inherent potential for incorrectly identifying toxic samples as not
 toxic (i.e., false negatives).  The SLCs reflect the lower bound  of ecologically relevant
 sediment concentrations (i.e., background concentrations), but may not necessarily define
 actual effect concentrations (i.e., false positives; non-toxic samples identified  as toxic).
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 Although the TRGs with which the residue-based SQGs were derived are considered to be
 highly ecologically relevant, more uncertainty is associated with the models which are used
 to determine the BSAFs.

 The  SEM-AVS and ESB mixture models were assigned  low uncertainty  relative to
 establishing causality because these guidelines are directly derived from experimental
 determinations of effects of specific chemicals.  In contrast, ERLs and ERMs, AETs, and
 SLCs were assigned higher levels of uncertainty because these  guidelines  are  derived
 primarily from field observations in which cause and effect relationships were equivocal (i.e.,
 the sediments contained mixtures of contaminants and, hence, determining the identity of the
 causative agents directly is difficult).  Sensitivity was evaluated relative to estimating
 relatively low contaminant concentrations (i.e., minimize false negatives while allowing for
 a higher probability of false  positives).  Optimizing sensitivity (e.g., minimize false
 negatives) needs to be balanced with ecological relevance (e.g., minimize both false positives
 and false negatives).  Low uncertainty with respect to sensitivity was assigned to the ERLs
 and SLCs because they tend to be the lowest SQGs.  Most of the other  SQGs were
 considered to have a higher level of uncertainty because they are generally higher values
 (e.g., ESBs, ERMs, and SEM-AVS).  The AETs were assigned a high level of uncertainty
 with respect to sensitivity since they only increase with the addition of new data,  making
 them particularly prone to false negatives.  In contrast, the residue-based  SQGs were
 considered to have a lower level of uncertainty because the TRGs upon which they are based
 are based on the results of chronic toxicity tests on sensitive species.

 Interferences are considered to be related to biotic or abiotic factors that could influence the
 SQGs derivation beyond the direct effects of specific contaminants. Because the SLCs are
 based entirely on benthic community data, they were considered to have the highest level of
 uncertainty.   In contrast,  residue-based guidelines are derived  from direct  analytical
 determination and are not subject to the same types of interferences.  Uncertainty in the
 degree of standardization was evaluated on the basis of peer review.  Approaches for
 determination of ESBs, ERLs and ERMs, and SEM-AVS have been published in the peer-
 reviewed literature and, hence, were assigned a low degree of uncertainty.  In contrast, the
 ESB mixture models (in the early stages of development with sediments), TRGs, and AETs

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 had not been widely peer reviewed in the literature at the time of the evaluation by Ingersoll
 etal. (1997).

 SQGs were considered to be discriminatory if they could be used to correctly classify toxic
 and non-toxic samples.  The ESBs and the ERLs and ERMs have been demonstrated to
 provide accurate tools for correctly predicting toxic and non-toxic responses in the field. In
 contrast, the SLCs have a poor ability to discriminate the range of adverse effects that could
 occur. Sediment samples with contaminant concentrations that exceed the AETs have a high
 probability of being toxic. However, the AETs may not reliably discriminate samples with
 lower levels of contamination with respect to their potential for adverse biological effects
 (i.e., false negatives). The factors that are considered to influence bioavailability are directly
 considered in the derivation of the ESBs, SLCs, SEM-AVS, and residue-based guidelines.
 Although other guidelines (i.e., ERLs and ERMs, AETs) are largely based on dry-weight
 concentrations,  it  is possible to refine the  approaches  to explicitly  consider other
 normalization procedures.

 Field validation was evaluated by Ingersoll etal. (1997) as an assessment of the predictability
 of the SQGs using a number of independent data sets (i.e., not used to derive the SQGs).
 Ingersoll et al. (1997) concluded that all of the SQGs listed in Table 5 were not adequately
 field validated.   Subsequent  to this  analysis by Ingersoll et al. (1997), there have been
 numerous publications that have demonstrated the predictive ability of co-occurrence-based
 SQGs, such as ERLs and ERMs (e.g., Long etal.  1998b; Field ef al. 1999; 2002; MacDonald
 et al.  2000a; 2000b; 2002c;  USEPA 2000b; Ingersoll et al.  2001; 2002; Wenning and
 Ingersoll 2002).

 In summary, Ingersoll etal. (1997) concluded that there is sufficient certainty associated with
 SQGs to recommend their use in assessments of sediment quality.  In particular, ESBs, ERLs
 and ERMs, SEM-AVS, and residue-based SQGs generally have less uncertainty in their
 present applications than other guidelines. Although ESB mixture models were generally
 considered to have somewhat higher levels of uncertainty compared to approaches derived
 using field-collected sediment, they address the critically important issue of the interaction
 of COPCs in complex mixtures. Importantly, a number or recent publications confirm that
 approaches that evaluate mixtures in sediment are  essential  for correctly predicting the
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       presence and absence of sediment toxicity (MacDonald etal. 2000a; 2000b; Ingersoll etal.
       2001;  2002; USEPA  2000a; Wenning  and Ingersoll 2002).   Toxi city identification
       evaluations (TIEs) and spiked-sediment exposures were recommended by Ingersoll et al.
       (1997) to help better establish cause and effect relationships between sediment chemistry and
       toxi city.
2.6   Interpretation of Data
       Sediment chemistry data alone do not provide an adequate basis for assessing the hazards
       posed by sediment-associated  contaminants  to aquatic organisms  or other  receptors.
       Interpretive tools are also required to determine if sediment-associated contaminants are
       present at concentrations which could, potentially, impair the aquatic organism, aquatic-
       dependent wildlife, and/or human health.  In this respect, the SQGs used in an assessment
       of sediment contamination need to provide a scientifically-defensible basis for evaluating the
       potential effects of sediment-associated COPCs on aquatic organisms, wildlife, and/or human
       health.  Once the sediment chemistry data have been assembled, the quality and sufficiency
       of the data needs to be determined using explicitly defined evaluation criteria, such as those
       outlined in Appendix 4 of Volume ILL If the sediment chemistry data do not meet the quality
       needed for the assessment, repeating certain components of the sampling program may be
       necessary.

       The assessment of sediment chemistry data consists of three main steps (Figure 1). First, the
       measured concentrations of COPCs at the sampling stations should be compared to regional
       background levels to determine if they are elevated relative to the background conditions
       (Appendix 2 of Volume HI). Next, the concentrations of sediment-associated COPCs should
       be compared to applicable SQGs for the protection of aquatic life. Finally, the levels of
       contaminants in  sediments  should be  compared to  the bioaccumulation-based SQGs,
       including those for the protection of  wildlife and the protection of human health.
       Problematic levels of contamination are indicated when sediment-associated COPCs are
       present at concentrations above one or more of the various SQGs and  are present above

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 background levels. However, the results of the sediment chemistry assessment should not
 be viewed in isolation. Instead, these results should be evaluated in conjunction with data
 on the other indicators of sediment quality conditions measured within the assessment area
 to support the sediment quality  assessment (e.g., ecological  and/or human health risk
 assessment).

 A variety of approaches have been used to determine if sediments exceed SQGs.  For
 example, the number and/or magnitude of exceedances of individual SQGs has been used
 to classify sediment samples as toxic or non-toxic (i.e., MacDonald et al.  1996; USEPA
 1996).  Alternatively, procedures have been recently described for calculating combined
 effects of mixtures in sediment. Crane et al. (2000; 2002), USEPA (2000b), and Ingersoll
 etal. (2001) described the relationship between mean probable effect concentration quotients
 (PEC-Qs) and the toxicity of whole sediments to amphipods and midges in short- and long-
 term exposure tests (see Appendix 3 of Volume III for a description of how PEC-Qs are
 calculated). Field et al.  (1999; 2002) described a new procedure for evaluating matching
 marine sediment chemistry and toxicity data using logistic regression models. These models
 can  be used  to estimate the probability of observing an effect based on  measured
 concentrations of COPCs. Mixture models based on equilibrium partitioning have also been
 developed for assessing the toxicity of non-ionic organic compounds (Swartz et al. 1995; Di
 Toro and McGrath 2000) or metals (Ankley et al.  1996) in sediment.

 The principal metrics for pore-water chemistry are concentrations of contaminants in water.
 Targets for each of these metrics can be established from a variety of benchmarks for
 assessing water chemistry that have been published in the scientific literature. For example,
 numerical water quality criteria (WQC), such as those promulgated by the USEPA (1999),
 and site-specific water quality standards  provide relevant tools to  assessing pore-water
 quality conditions (MacDonald et al. 2002c).  Such WQC  are considered to be relevant for
 assessing pore-water quality because Di  Toro et al. (1991) reported that benthic organisms
 tend to show similar chemical sensitivities as water  column  organisms.  Alternatively,
 toxicity thresholds for pore water can be established using data available in the toxicological
 literature (i.e., median lethal  concentrations or median effective concentrations; LC50s or
 EC50s) for receptors of concern at the site under consideration (Table 6).  Such toxicity
 thresholds identify the concentrations of contaminants in water that are likely to cause acute
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 and chronic toxicity to aquatic plants, amphipods and other aquatic invertebrates, and fish.
 USEPA (2000a) reported toxicity thresholds from 10-day water-only toxicity tests with the
 amphipodHyalellaazteca, the midge Chironomus tentans, and the oligochaQteLumbriculus
 variegatus, for a number of COPCs at contaminated sites.

 Comparison of the concentration of a chemical in pore water to an LC50 or an EC50 for that
 chemical provides a means of determining if the concentration of that compound in the pore
 water was sufficient to cause direct toxicity to sediment-dwelling organisms (i.e., sufficient
 to cause sediment injury; Table 6). By dividing the pore-water concentrations of each COPC
 in each sample by  the reported LC50 concentration for that  compound, it is possible to
 calculate a value that can be used to evaluate the overall toxicity of the sample. This value
 also provides a basis for reporting COPC concentrations in terms of the number of toxic
 units.  The number of toxic units of each compound can be  summed to evaluate the
 combined toxic effect of chemicals with a similar mode of toxicity. Samples that contain >1
 toxic units are likely to be toxic to sediment-dwelling organisms. See Ankley et al. (1996)
 for a description of an approach that was used to evaluate toxic units of metals in pore-water
 samples.

 Interpretation of sediment chemistry data relative to wildlife or human health necessitates the
 development of sediment quality targets that can be used to evaluate  the extent to which
 these receptors are being protected. Such targets can be established by selecting appropriate
 SQGs for each bioaccumulative COPC at the site.  The bioaccumulation-based SQGs for the
 protection of wildlife or human  health that  were developed  by the  New York  State
 Department  of Environmental Conservation  (NYSDEC  1999) and Washington  State
 Department of Health (1995; 1996) provide a basis for establishing sediment quality targets
 relative to the protection of these receptors.
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2.7   Recommendations

       Sediment chemistry represents an essential  indicator of sediment  quality conditions in
       freshwater ecosystems. More specifically, sediment chemistry data are required to evaluate
       the  nature, magnitude, and  areal extent of sediment  contamination.  The following
       recommendations are offered to support the design and implementation of sediment quality
       assessments:

          •  The chemical analytes that are included in the  sediment quality assessment
             program should include the COPCs that are identified based on the preliminary
             site investigation and the variables that support interpretation of the resultant data
             on the COPCs;

          •  Evaluations  of the chemical composition  of  sediments  should  focus  on
             determining the total concentrations of COPCs, total organic carbon, and SEM-
             AVS in whole-sediment samples.  Analysis of other media types (e.g., pore
             water, elutriates)  may  also be conducted depending on the objectives of the
             investigation and the availability of resources;

             Qualitative descriptions of the sediment should include color, texture, and the
             presence of petroleum sheens, macrophytes, or animals. Monitoring the odor of
             sediment samples should be avoided due to the hazards associated with exposure
             to volatile chemicals;

          •  The benchmarks  (e.g.,  SQGs) that are to  be used in the sediment quality
             assessment should be identified in the data analysis plan, which is developed as
             part of the overall problem formulation process;

          •  Assuring the quality of sediment chemistry data is of fundamental importance to
             the integrity of the overall investigation.  For this reason, it is important to design
             and implement an effective QAPP for the program and include it as part of the
             sampling and analysis plan (SAP);

          •  The whole-sediment and pore-water chemistry data that are generated during an
             investigation of sediment quality conditions should be evaluated relative to the

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        project DQOs to determine which data are appropriate for use in the assessment
        (e.g., to determine if DQOs for accuracy, precision, and detection limits have
        been met);

        Numerical SQGs, such as consensus-based PECs and TECs (MacDonald et al.
        2000a; 2000b;  USEPA 2000b; Ingersoll et al. 2001; 2002; Macfarlane  and
        MacDonald 2002) represent effective tools for assessing the potential effects of
        contaminated sediments on sediment-dwelling organisms (Tables 1 and 2). The
        potential effects of contaminated sediments on aquatic-dependent wildlife  and
        human health can be evaluated using bioaccumulative-based SQGs, such as those
        that were derived by NYSDEC (1999);

        Toxicity thresholds for pore water provide useful tools for assessing the potential
        effects of contaminants on sediment-dwelling organisms (Table 6);

        Because contaminated   sediments  typically contain  mixtures  of COPCs,
        approaches that consider the influence of mixtures [such as those developed by
        Swartz et al. (1995); Field et al. (1999; 2002); MacDonald et al. (2000b);
        USEPA (2000b); Ingersoll et al. (2001; 2002)] should be used to evaluate the
        effects of contaminated sediment on sediment-dwelling organisms;

        Whenever possible, decisions  regarding the  management of  contaminated
        sediments should be made using a weight of evidence, which includes sediment
        chemistry  and  other  relevant data.   Nevertheless, the results  of numerous
        evaluations of the predictive ability  of SQGs indicate that sediment chemistry
        data can be used to accurately classify sediments as toxic or not toxic (i.e.,
        typically with >75% correct classification using the results of whole-sediment
        toxicity tests; Wenning and Ingersoll 2002).  Therefore, it is not unreasonable to
        make sediment management decisions using sediment chemistry data alone (i.e.,
        with SQGs) at sites where the costs  of further  investigations are likely to
        approach or exceed the costs of sediment remediation; and,

        At sites  where multiple indicators  of sediment quality conditions are to be
        applied, sampling strategies must be developed and implemented that facilitate
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        the collection of matching sediment chemistry and biological effects data (i.e.,
        by preparing split samples for toxicity, chemistry, and benthos evaluations).
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Chapter 3.    Whole-Sediment  and Pore-Water Toxicity
                   Testing

3.0  Introduction

      Laboratory sediment toxicity tests can provide rapid and highly relevant information on the
      potential toxicity of contaminated sediments to benthic organisms.  Acute (10- to 14-day
      exposures) and chronic (21- to 60-day exposures) toxicity tests have been developed to
      evaluate the biological significance of sediment contamination. Tests have been designed
      to assess the toxicity  of whole sediments (solid phase), suspended sediments, elutriates,
      sediment extracts, or  pore water.  The organisms that can be tested with these methods
      include microorganisms, algae, invertebrates, and fish. This chapter is intended to provide
      guidance on the selection of toxicity tests and interpretation of the associated results to
      support assessments of sediment quality conditions of contaminated sites.
3.1  Selection of Metrics and Targets for Sediment Toxicity

      The objective of a sediment toxicity test is to determine whether contaminated sediments are
      harmful to benthic organisms (ASTM 200la; USEPA 2000a). These tests can be used to
      measure the  interactive  toxic  effects of complex  chemical  mixtures in  sediment.
      Furthermore,  knowledge of specific pathways of interactions among sediments and test
      organisms is not necessary to conduct the tests.  Sediment tests can be used to: (1) determine
      the relationship between toxic effects and bioavailability; (2) investigate interactions among
      chemicals; (3) compare the sensitivities of different organisms; (4) determine spatial and
      temporal distribution of contamination; (5) evaluate hazards of dredged material; (6) measure
      toxicity as part of product licensing or safety testing; (7) rank areas for clean up; and, (8)
      estimate the effectiveness of remediation or management practices.
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 The  results of sediment  toxicity tests  can be used to assess the bioavailability  of
 contaminants in field-collected sediments. The responses of organisms exposed to field-
 collected sediments are often compared to the response of organisms exposed to a control
 and/or a reference sediment. The results of toxicity tests on sediments spiked with one or
 more chemicals can also be used to help establish cause and effect relationships between
 chemicals and biological responses. The results of toxicity tests with test materials spiked
 into sediments at different concentrations are often reported in terms of an LC50, a median
 inhibition concentration (IC50), a no observed effect concentration (NOEC), or a  lowest
 observed effect concentration (LOEC; ASTM 2001a; USEPA 2000a).

 The  choice of a test organism has a  major  influence on the relevance,  success, and
 interpretation of a test.  As no one organism is best suited for all applications, considering
 the intended uses of the resultant data is important in the selection of toxicity tests. The
 following criteria were considered in the selection of the methods and species that were to
 be described in ASTM (200la) and USEPA (2000a;  Table 7).  Ideally, a test organism
 should:

    •  Have  a  toxicological  database  demonstrating relative   sensitivity  and
       discrimination to a range of COPCs in sediment;

    •  Have a database for inter-laboratory comparisons  of procedures  (for example,
       round-robin studies);

    •  Be  in  contact  with sediment  (e.g., water column  vs.  sediment-dwelling
       organisms);

    •  Be readily available through culture or from field collection;

    •  Be easily maintained in the laboratory;

    •  Be easily identified;

    •  Be ecologically or economically important;

    •  Have a broad geographical distribution, be indigenous to the site being evaluated
       (either present or historical), or have a niche similar to organisms of concern at

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        the  site  (for example,  similar feeding guild  or behavior to the indigenous
        organisms);

    •   Be tolerant of a broad range of sediment physico-chemical characteristics (e.g.,
        grain size); and,

    •   Be compatible with selected exposure methods and endpoints.  The method
        should also  be  peer reviewed and confirmed with  responses with  natural
        populations of benthic organisms.


 Of these criteria, a database demonstrating relative sensitivity to contaminants, contact with
 sediment, ease of culture in the laboratory, inter-laboratory comparisons, tolerance of varying
 sediment physico-chemical characteristics,  and confirmation with responses  of natural
 benthos populations were the primary criteria used for selecting the amphipod Hyalella
 azteca and the midge Chironomus tentans for describing test methods, as outlined by ASTM
 (200la) and USEPA (2000a; Table 7).  Procedures for conducting  sediment tests with
 oligochaetes, mayflies, and other amphipods or midges are also outlined in ASTM (200la)
 and in Environment Canada (1997b). However, USEPA (2000a) chose to not develop
 methods for conducting sediment toxicity tests with these additional organisms because they
 did not meet all the required selection criteria listed in Table 7. For both of the selected
 species (Hyalella azteca and Chironomus  tentans),  survival is the principal endpoint
 measured in 10- to 14-day acute toxicity tests (although growth is also commonly measured),
 while survival,  growth,  emergence (midges only) and/or reproduction are the principal
 endpoints measured in longer-term exposures.

 USEPA (2000b) evaluated relative endpoint and organism sensitivity in a database developed
 from 92 published reports that included a total of 1657 field-collected samples with high-
 quality matching  sediment toxicity  and  chemistry data.  The  database  was comprised
 primarily of 10- to 14-day or 28- to 42-day toxicity tests with the amphipod Hyalella azteca
 (designated as the HA10 or HA28 tests) and 10- to 14-day toxicity tests with  the midges
 Chironomus tentans or  Chironomus  riparius (designated as the CS10 test).   Endpoints
 reported in  these tests were primarily survival or growth.  For each test and endpoint, the
 incidence of effects above and below various mean PEC quotients (mean quotients of 0.1,

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                                      WHOLE-SEDIMENT AND PORE-WATER TOXICITY TESTING - PAGE 29
 0.5, 1.0, and 5.0) was determined. In general, the incidence of sediment toxicity increased
 consistently and markedly with increasing levels of sediment contamination.  See Appendix
 3 of Volume III for additional information on the calculation of mean PEC quotients.

 A higher incidence of toxicity with increasing mean PEC-Q was observed in the HA28 test
 compared to the short-term HA10 or CS10 tests and may be due to the duration of the
 exposure or the sensitivity of the growth endpoint in the longer HA28 test. A 50% incidence
 of toxicity in the HA28 test corresponds to a mean PEC-Q of 0.63 when survival or growth
 were used to classify a sample as toxic Figure 2 (USEPA 2000b). By comparison, a 50%
 incidence of toxicity is expected at a mean PEC-Q of 3.2 when survival alone was used to
 classify a sample as toxic in the HA28 test.  In the CS10 test, a 50% incidence of toxicity is
 expected at a mean PEC-Q of 9.0 when survival alone was used to classify a sample as toxic,
 or at a mean PEC-Q of 3.5 when  survival or growth were used to classify a sample as toxic.
 In contrast, similar mean PEC-Qs resulted in a 50% incidence of toxicity in the HA10 test
 when survival alone (mean PEC-Q of 4.5) or when survival or growth (mean PEC-Q of 3.4)
 were used to classify a sample as toxic. The results of these analyses indicate that both the
 duration of the exposure and the endpoints measured can influence whether a sample is
 found to be toxic or not.  The longer-term tests in which growth and survival are measured
 tended to be more sensitive than shorter-term tests, with an acute to chronic ratio on the order
 of six indicated for Hyalella azteca.  Based on these analyses, if only one of these tests were
 performed,  it would be desirable to conduct chronic (i.e., 28- to 42-day) sediment toxicity
 tests with Hyalella azteca measuring survival and growth (as length) instead of 10- to 14-day
 tests with Hyalella azteca, Chironomus tentans, or Chironomus riparius.

 Relative species sensitivity frequently varies among chemicals; consequently, both ASTM
 (200la) and USEPA (2000a) recommend the use of a battery of tests to assess sediment
 quality, including organisms representing different trophic levels. However, testing multiple
 species with every sediment sample can be very costly. An alternate approach could be to
 perform a preliminary evaluation on  a limited number of samples from a site using a battery
 of tests (i.e., see procedures for various species outlined in ASTM 2001a). This preliminary
 evaluation could be used to  identify sensitive species or endpoints to include in a more
 comprehensive assessment at the site. The preliminary evaluation should include samples
 representing a gradient of contamination at the site of interest. This approach was taken by
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       Kemble etal. (1994) in an assessment of the toxicity of metal-contaminated sediments in the
       Clark Fork River in Montana. A battery of acute and chronic whole-sediment and pore-water
       tests were conducted with samples collected from this site. The results of this investigation
       indicated that a 28-day whole-sediment toxicity test with Hyalella azteca measuring survival
       and growth (as length) was the most sensitive metric across a gradient of metal-contaminated
       stations at the site. The results of chronic toxicity test with Hyalella azteca were also
       predictive of effects observed on benthic community structure at the site (Canfield et al.
       1994).  Therefore, Kemble et al.  (1994) recommended that future evaluations of sediment
       toxicity at the site should use chronic tests with Hyalella azteca rather than testing a suite of
       toxicity tests.
3.2   Availability of Standard Methods
       Whole-sediment toxicity tests are the most relevant for assessing the effects of contaminants
       that are associated with bottom sediments.  Standard methods have been developed for
       conducting whole-sediment toxicity tests with freshwater sediments by ASTM (200la),
       Environment Canada (1997a; 1997b), and USEPA (2000a). The Organization of Economic
       Cooperation and Development (OECD) is in the process of developing standard methods for
       chronic sediment toxicity testing with midges. These methods can be used to assess the
       acute or chronic toxicity of sediment-associated COPCs on the amphipod, Hyalella azteca,
       the midges, Chironomus tentans and Chironomus riparius, the mayfly, Hexagenia limbata,
       and several other species of amphipods, cladocerans, and oligochaetes (Table 8). Standard
       methods have been described for conducting chronic whole-sediment toxicity tests with the
       amphipod Hyalella azteca and the midge Chironomus tentans (ASTM 200la; USEPA
       2000a).  Endpoints measured in these chronic tests  include effects on survival,  growth,
       emergence (midge), and reproduction in 28- to 60-day exposures.

       The procedures outlined in these standard methods can be modified to assess toxicity to other
       benthic invertebrate species that occur in freshwater environments.  However, the results of
       tests, even those with the same species, using procedures different from those described in

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 the ASTM (200la) and USEPA (2000a) may not be comparable and using these different
 procedures may alter the bioavailability of sediment-associated COPCs.  Comparison of
 results obtained  using modified versions of these procedures  might provide useful
 information concerning new concepts and procedures for conducting sediment tests with
 aquatic organisms.  If tests are conducted with procedures different from those described in
 ASTM (200la)  or in USEPA  (2000a),  additional  tests  are  required  to  determine
 comparability of results (i.e., conducted on split sediment samples).

 Several endpoints  are suggested to measure potential effects of COPCs in sediment,
 including survival, growth, behavior, or reproduction; however, survival of test organisms
 in 10-day exposures is the endpoint most commonly reported. Such short-term exposures,
 which only measure effects on survival, can be used to evaluate the effects associated with
 exposure  to high levels of contamination in sediments, but may  not be as relevant for
 assessing sediments with moderate levels of contamination (ASTM 2001a; USEPA 2000a).
 Long-term toxicity testing methods recently described in ASTM (200la) and in USEPA
 (2000a) can be used to measure effects on reproduction, as well as long-term survival and
 growth.   Reproduction is a key variable influencing  the  long-term  sustainability  of
 populations and has  been shown to provide valuable and sensitive information in the
 assessment of sediment toxicity (ASTM 200la; USEPA 2000a). Furthermore, as concerns
 have emerged regarding the environmental significance of chemicals that can act directly or
 indirectly on reproductive endpoints (e.g., endocrine disrupting compounds), the  need for
 comprehensive reproductive toxicity tests has become increasingly apparent (SETAC 1999).
 Sub-lethal endpoints in sediment tests have also been shown to provide better estimates of
 responses of benthic communities to COPCs in the field (Hayward 2002).

 The decision regarding the selection of short-term  or long-term toxicity tests depends on the
 objectives of the assessment.  In some instances,  sufficient information may be gained by
 measuring growth  in  10-day tests  (i.e.,  for assessing highly  contaminated sediments).
 However, longer term tests are needed to evaluate the effects associated with exposure to
 moderately contaminated sediments. Likewise, long-term tests are needed to directly assess
 effects on reproduction. Nevertheless, measurement of growth in these toxicity tests may
 serve as an indirect estimate of reproductive effects of COPCs associated with sediments
 (ASTM 200la; USEPA 2000a).
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 Use of sub-lethal endpoints provides important information for assessing the ecological risks
 associated with exposure to contaminated sediments.  As such, numerous regulatory
 programs require the use of sub-lethal endpoints in various decision-making processes
 (USEPA 2000a), including:

    •  Monitoring for compliance with water quality criteria (and state water quality
       standards);

    •  National Pollution Discharge Elimination System (NPDES) effluent monitoring
       (including chemical-specific limits and sub-lethal endpoints in toxicity tests);

    •  Federal Insecticide, Rodenticide and Fungicide Act (FIFRA) and the Toxic
       Substances  Control Act (TSCA, tiered assessment includes several sub-lethal
       endpoints with fish and aquatic invertebrates);

    •  Superfund   (Comprehensive  Environmental Responses,  Compensation  and
       Liability Act; CERCLA);

    •  Organization of Economic Cooperation  and Development (OECD, sub-lethal
       toxicity testing with fish and invertebrates);

    •  European Economic Community (EEC, sub-lethal toxicity testing with fish and
       invertebrates); and,

    •  The Paris Commission (behavioral endpoints).


 ASTM (200la) and USEPA (2000a) outline methods for measuring effects on reproduction
 in 42-day tests with Hyalella azteca or 60-day tests with Chironomus tentans. The results
 of water-only studies in chronic exposures to DDD, fluoranthene, or cadmium indicate that
 measures of reproduction are often more  sensitive compared to  measures of survival or
 growth for  these species (Kemble et al. In preparation).  The  chronic  sediment toxicity
 methods with Hyalella azteca have been applied to evaluate a variety  of field collected
 sediments (e.g.,  Ingersoll et al. 2001; MacDonald et al. 2002c).  However, the methods for
 conducting  chronic sediment toxicity tests with Chironomus tentans have not been applied
 routinely to assess the toxicity of field-collected sediments.  Therefore,  additional studies

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                                      WHOLE-SEDIMENT AND PORE-WATER TOXICITY TESTING - PAGE 3 3
 need to be conducted with field-collected sediments before the chronic methods with
 Chironomus tentans for measuring reproductive endpoints are applied routinely to evaluate
 the toxicity of contaminated sediments.

 ASTM  (200la) and  USEPA  (2000a)  recommend additional  research and methods
 development with standard methods for conducting sediment toxicity tests to:

    •   Evaluate additional test organisms;

    •   Further evaluate the use of formulated sediment;

    •   Refine sediment dilution procedures;

    •   Refine sediment TIE procedures;

    •   Refine sediment spiking procedures;

    •   Develop in situ toxicity tests to assess sediment toxicity and bioaccumulation
        under field conditions;

    •   Evaluate relative sensitivities of endpoints measured in tests;

    •   Develop methods for new species;

    •   Evaluate relationships between toxicity and bioaccumulation; and,

    •   Produce additional data on confirmation of responses in laboratory tests with
        natural populations of benthic organisms.


 Some issues  that may be considered in  interpretation of test results are the subject of
 continuing research, including:  the influence of feeding on contaminant bioavailability;
 nutritional requirements of the test organisms; and, additional performance  criteria for
 organism health.

 In addition to whole-sediment toxicity tests, various procedures are available for assessing
 the potential for adverse effects on aquatic organisms due to the resuspension of sediments
 or partitioning of COPCs into pore water or into  the water column.  However, standard
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       methods have not been developed for such methods.  Perhaps the most frequently used of
       these is the bacterial luminescence test (Microtox; Schiewe etal. 1985; Burton and Stemmer
       1988; Johnson and Long 1998) or cladoceran tests (Burton et al. 1996). Tests using algae,
       invertebrates, and fish have also been adapted to assess the toxicity of the suspended and/or
       aqueous phases, including pore  water (ASTM 200Ib).  These exposures are typically
       conducted for 4 to 10 days, with survival measured as the primary endpoint. ASTM (200la)
       and USEPA (2000a) describe procedures for isolating and handling pore-water samples from
       whole-sediment samples.
3.3   Advantages and Disadvantages

       Toxicity tests with aquatic organisms have  a number of advantages that make  them
       particularly relevant for evaluating the effects of contaminated sediments on  aquatic
       organisms (Table  9;  ASTM 200la; USEPA 2000a).  First, they  provide quantitative
       information on sediment toxicity that provides a basis for discriminating between impacted
       and unimpacted sediment samples.  In addition, standard methods have been established to
       support the generation of reliable data and minimize the effects of the physical characteristics
       of the sediments.  The results of these tests are also ecologically- and socially-relevant
       because they commonly employ species which are familiar or important to area residents.
       Furthermore, studies conducted throughout freshwater environments in North America have
       demonstrated that aquatic organisms respond primarily to the COPCs in the sediments and
       pore water (i.e., not typically to physical factors or other variables; ASTM 2001a; USEPA
       2000a).  These characteristics make toxicity tests relevant for evaluating COPC-related
       impacts in freshwater systems. Moreover, techniques for identifying the chemicals that are
       causing toxicity are being refined (i.e., TIE), which further support the identification of
       contaminants of concern (COCs; i.e., the  substances that are causing or substantially
       contributing to sediment toxicity; USEPA 1991).

       Toxicity tests also have several disadvantages which influence their application in sediment
       quality assessments (Table 9). For example, many of the tests that are currently used involve

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                                            WHOLE-SEDIMENT AND PORE-WATER TOXICITY TESTING - PAGE 3 5
       short-term exposures (i.e., 10-day) and, hence, may not be sensitive enough to detect sub-
       lethal effects on sensitive species. In addition, field-collected sediments are manipulated
       before testing, which may affect their integrity and toxicity.  Similarly, certain sediment
       phases (e.g., organic extracts, elutriates) may be less relevant for evaluating the in situ effects
       of toxic substances in sediments. Tests with field-collected samples may not discriminate
       effects of individual chemicals.  Likewise, the ecological relevance of certain tests has not
       been fully established (e.g., Microtox; although it was not intended for this purpose but rather
       as an indicator of potential exposure). Importantly, certain test organisms may be more
       sensitive to certain classes of COPCs than others; therefore, it is desirable to use a suite of
       tests to cover the range of sensitivities exhibited by sediment-dwelling organisms in the field.
       See ASTM (200la) and  USEPA (2000a) for a more complete description of potential
       interferences associated with sediment toxicity tests.

       Toxicity tests with fish also have several limitations which influence their application in
       sediment quality assessments.  First,  methods for assessing the toxicity of contaminated
       sediments to fish have not been standardized. In addition, toxicity tests with fish may be less
       sensitive than  similar tests with freshwater invertebrates since fish derive more of their
       exposure to COPCs from the overlying water (as opposed to exposure to pore water or during
       the processing of contaminated sediments). Furthermore, most of the tests that are currently
       available involve short-term exposures (i.e., 4- to 10-day) and, hence, may not be sensitive
       enough to detect sub-lethal effects on sensitive fish species.  It is  also difficult to obtain
       sufficient sample  volumes to support testing with pore water.   Finally,  field-collected
       sediments are manipulated prior to testing, which may affect their toxicity.
3.4   Evaluation of Data Quality
       Use of performance-based methods have been recommended for use in sediment toxicity
       testing (ASTM 200la; USEPA 2000a). Performance-based methods permit the use of
       appropriate methods that meet pre-established performance standards.  For example, no
       single method is appropriate for culturing test organisms (ASTM 200la; USEPA 2000a).

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                                      WHOLE-SEDIMENT AND PORE-WATER TOXICITY TESTING - PAGE 36
 However, having healthy test organisms of known quality and age for testing is critical to the
 success of the toxicity test. The performance-based criteria described in these methods allow
 laboratories to optimize culture methods and minimize effects of test organism health on the
 reliability and comparability of test results.  A QAPP should be developed to address the
 experimental design and sampling procedures for the toxicity tests (Chapter 5 of Volume II).

 Performance-based procedures are also established in ASTM (200la), Environment Canada
 (1997a; 1997b), and USEPA(2000a) for establishing the acceptability of a toxicity test. For
 example, Table 10 from ASTM  (200la) and  USEPA (2000a)  outlines the method
 recommended for conducting chronic sediment toxicity tests with the amphipod Hyalella
 azteca, while Table 11  lists the test acceptability requirements for chronic sediment toxicity
 tests with Hyalella azteca.  The primary requirements for meeting test acceptability include
 the age of organisms at the start of the exposure, minimum survival and growth of organisms
 at the  end  of  the exposure  in the control sediment, maintenance  of water quality
 characteristics of the overlying water during the exposure, documentation of the  quality of
 the cultures used to obtain organisms for testing, maintenance of the exposure  system, and
 handling of sediments for testing (Table 11).  ASTM (2001a) and USEPA (2000a) have
 provided specific definitions for the use of the terms "must" and "should" relative to test
 acceptability. "Must" is used to express an absolute requirement, that is, to state  that a test
 has to be designed to satisfy the specified conditions, unless the purpose of the test requires
 a different design. "Must" is used only in connection with the factors that relate directly to
 the  acceptability of a  test.  "Should"  is  used to state that  the specified  condition is
 recommended and ought to be met if possible.  Although the violation of one "should" is
 rarely a serious matter, violation of several will  often render the  results  questionable.
 Additional Quality Assurance and  Quality Control procedures for conducting  sediment
 toxicity tests are outlined in ASTM (200la), Environment Canada (1997a; 1997b), and
 USEPA (2000a).
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3.5   Methodological Uncertainty
       A review of uncertainty associated with the endpoints commonly used in sediment ecological
       risk assessments and approaches for addressing these sources of uncertainty was described
       in Ingersoll et al. (1997).  The endpoints included in this evaluation included: toxicity tests
       (both the fraction tested and the endpoints selected); benthic invertebrate assessments;
       bioaccumulation assessments; sediment chemistry; and, sediment chemistry and SQGs. A
       series of criteria were established by Ingersoll etal. (1997) to support consistent assessments
       of the uncertainty associated with each measurement endpoint.  These evaluation criteria
       included:  precision;  ecological  relevance;  causality;   sensitivity;   interferences;
       standardization; discrimination; bioavailability; and, field validation (Tables 12 and 13).

       The results of these evaluations are presented in Tables 12 and 13.  Uncertainty associated
       with lack of knowledge is indicated with an asterisk in these tables to differentiate from
       systematic uncertainty which can be rectified (methodologically ) or quantified (sampling
       decisions and design). Uncertainty relative to laboratory toxicity tests was divided into two
       categories:   Uncertainties related to the phase tested; and, uncertainties related to the
       selection of endpoints measured in toxicity tests (Ingersoll etal. 1997). A diverse array of
       exposure phases have been used in sediment toxicity tests.  Six principal phases have been
       evaluated in toxicity tests (Table 12):

          •   Whole  sediment using benthic invertebrates;

          •   Whole  sediment using pelagic organisms;

          •   Organic extracts of whole sediment;

          •   Suspended solids

          •   Elutriates; and,

          •   Pore water isolated from whole  sediment.
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 Whole-sediment toxicity tests were developed  to evaluate the effects associated with
 exposure to in-place sediments.  Toxicity tests with pore-water samples isolated from
 sediment were developed for evaluating the potential in situ effects of contaminated sediment
 on aquatic organisms. Toxicity tests with organic extracts were developed to evaluate the
 effects of the maximum concentrations of organic contaminants associated with a sediment.
 Tests with  elutriate samples  and  suspended solids measure the potential  release of
 contaminants from sediment to the water column during disposal of dredged material or
 during sediment resuspension events.

 Each of the six phases considered in sediment toxicity tests was evaluated in Ingersoll et al.
 (1997).  The uncertainty associated with each phase is a function of inherent limitations of
 the test (e.g., testing of whole  sediments has greater ecological significance than organic
 extracts) and the stage of development of the response as a toxicological endpoint (e.g.,
 whole-sediment tests are much better developed than pore-water tests).   In Table  12,
 precision was evaluated in terms of the replicability the particular measurement. Ecological
 relevance was evaluated in  terms of its linkage to the receptors which are to be protected.
 Causality was evaluated relative to the ability of the measure to determine the factors that
 adversely affect organisms exposed to contaminated sediments. Sensitivity was evaluated
 relative to the ability of the measure to identify sediments that have the potential to affect
 sensitive species in aquatic ecosystems.   Interferences were evaluated related to biotic or
 abiotic factors which could influence the response of the measurement beyond the direct
 effects of specific contaminants. Standardization was evaluated in terms of the level of peer
 review and the  publication  of standard methods. Discrimination was evaluated based on
 whether or not a graded response could be identified. Bioavailability was evaluated relative
 to the ability of the measure to determine the fraction of contaminants in sediment that is
 readily available to organisms.  Finally, field validation was evaluated relative to the extent
 to which the measure has been used to predict responses of benthic communities in the field.

 Whole-sediment tests were  considered to provide the most realistic phase for assessing the
 response of test organisms to exposures to sediment-associated COPCs (Table 12). Because
 organic extracts may alter the bioavailability of sediment-associated contaminants, toxicity
 tests conducted using this phase were considered to have a relatively low level of relevance.
 Similarly,  elutriate and  suspended solids tests are conducted using  a phase which may
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                                       WHOLE-SEDIMENT AND PORE-WATER TOXICITY TESTING - PAGE 39
 artificially alter the availability of contaminants.  In order to establish cause and effect
 relationships, it is necessary to link the toxicity test to appropriate measures of sediment
 chemistry, mixture toxicity models, spiked-sediment tests, and/or TIE procedures designed
 to help identifying specific compounds or classes of compounds responsible for toxicity.
 Ingersoll etal. (1997) provides a more complete summary of information presented in Table
 12.

 Uncertainties related to the selection of endpoints measured in toxicity tests focused on seven
 principal classes of response endpoints that are often measured in toxicity tests, including:
 survival; growth; reproduction; behavior; life tables; development; and, biomarkers (Table
 13;  Ingersoll et al. 1997). The uncertainties associated with each of the endpoints are a
 function of their inherent limitations (e.g., reproduction has greater ecological significance
 than biomarkers) and the stage of development of the response as a toxicological endpoint
 (e.g., acute lethality tests are much better developed than chronic reproductive tests).

 The uncertainty  associated with survival is less than that of the other endpoints used in
 sediment toxicity tests (Table  13).  This is because mortality  is an extreme response with
 obvious biological consequences. Also, a substantial body of literature concerning survival
 in sediment toxicity tests has been generated to date.  Biomarkers have significant sources
 of uncertainty as sediment toxicological  endpoints, especially with respect to ecological
 relevance  and interferences by non-treatment factors. The continued development and
 application of more sensitive and ecologically relevant endpoints (e.g., chronic effects on
 growth and reproduction, life cycle tables) has the potential to produce superior measurement
 endpoints for use in assessment of contaminated sediments.

 Toxicity tests, alone,  are not  useful for  identifying  the COPCs that are responsible for
 observed responses. Even linkage of test results to the list of chemicals measured during an
 exposure assessment might not provide all of the information needed to identify the potential
 causes of toxicity for a number of reasons, including:

        Chemicals responsible for toxicity may not have been  measured;
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          •   The bioavailability of chemicals in either pore water or in whole sediment can be
              uncertain; and,

          •   Correlative techniques (i.e., comparison of responses to chemical concentrations)
              may be unable to deal with multiple contributions from complex mixtures.


       Toxicity identification evaluation methods provide a useful approach for assessing toxicity
       contributions in sediment phases where unmeasured contaminants may be responsible for
       toxicity or where there are questions regarding bioavailability or mixture toxicity models
       (Ingersoll et al. 1997). The TIE methods consist of toxicity-based fractionation schemes that
       are capable of identifying toxicity due either to single compounds or to broad classes of
       contaminants with similar properties.  Sediment TIEs have typically been conducted using
       pore water as  the test phase;  however, methods are being developed  for testing whole
       sediments.  Ingersoll et al. (1997) provides a more complete summary of the information
       presented in Table 13.
3.6   Interpretation of Data
       For toxicity tests, the endpoints that are measured represent the primary metrics that are
       considered. Several methods have been used to establish targets for sediment toxicity tests.
       Most commonly, the responses of test organisms (e.g., survival or growth) in test sediments
       are compared to responses in control or reference sediments using a variety of statistical
       procedures. Samples in which the observed response of the test organism is significantly
       different from the control are designated as toxic.  Similarly, the responses in test sediments
       can be compared to that in reference sediments, provided that the reference sediments are
       demonstrated to be appropriate (i.e., non-toxic, chemical concentrations below threshold
       effect-type SQGs;  ASTM 200la; Environment Canada  1997a;  1997b; USEPA 2000a;
       2000b).  For some toxicity tests (i.e., 10-day marine amphipod survival), power analyses
       have been used to identify minimum significant differences (MSD) from the control (i.e., the
       results of power analyses can be used to identify the response value that is highly likely

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 significantly different from the negative control, based on a specified alpha level; Thursby
 et al. 1997). Using this approach, test sediments are designated as toxic if the response of
 the test organism is significantly different from the control and the response rate exceeds the
 MSD from the control. Such MSDs have not been routinely applied for the freshwater
 toxicity tests that are commonly used in sediment quality assessments.  Dilution series are
 often tested with pore water, elutriate,  or organic extracts samples, with results typically
 reported as an LC50 (Carr et al. 1996).

 Laboratory testing of sediment toxicity is an  essential component of the sediment quality
 assessment process. At present, the nature and extent of available information on the effects
 of sediment-associated contaminants is such that there is often uncertainty associated with
 predictions of the biological significance of sediment-associated contaminants (i.e., most of
 the data available for field collected samples do not support the establishment of cause and
 effect relationships). Therefore, biological testing is required to provide reliable information
 regarding the toxicity of sediments (generally a suite of biological tests is desirable) and to
 confirm the results of the sediment chemistry  assessment.

 Further biological testing is required to support three distinct aspects of the sediment quality
 assessment process.  First, biological  testing may be required to assess  the toxicity of
 sediments at stations where the concentrations of one or more COPCs is elevated above
 SQGs (e.g., PECs).  Second, biological testing may be required to assess the toxicity of
 sediments that may contain unmeasured substances (i.e.,  based on  the results  of  the
 preliminary site investigation). Third, biological effects data may be required to assess the
 site-specific applicability  of the SQGs.  In this respect, additional biological testing is
 required when the forms of the COPCs that are present may be less biologically available
 than those at other sites (i.e., the data that were used to support predictive ability evaluation
 of SQGs; USEPA 2000b).

 The steps that should be used to assess sediment toxicity data are outlined in Figure 3.  Once
 the sediment toxicity data have been assembled, the quality of the data needs to be evaluated
 in relation to the proj ect DQOs (see Appendix 3 of Volume II). If the sediment toxicity data
 do not meet the quality needed for the assessment,  it may be necessary to repeat certain
 components of the sampling and/or toxicity testing program.
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       The assessment of sediment toxicity data consists of two main steps (Figure 3). First, the
       results of the toxicity tests should be compared to the negative control data to determine if
       the sediments are significantly toxic. Next, the toxicity test results should be compared to
       data from appropriately selected reference stations. In this case, a reference sediment should
       be considered to be acceptable if it has been well-characterized and satisfies the criteria for
       negative controls (i.e., reference sediments should not be contaminated and reference results
       should not be significantly  different from controls).   Sediments that are found to be
       significantly toxic relative to control and reference  sediments should be considered to be
       problematic.  The results of the sediment toxicity  assessment should be considered in
       conjunction with the results of the companion measures of other indicators of sediment
       quality,  including sediment chemistry,  benthic invertebrate community structure, and
       bioaccumulation, that are conducted at the site.  ASTM (2001 a) and USEP A (2000a) provide
       a description of procedures for conducting statistical analyses of data from toxicity tests.
3.7   Recommendations

       The results of sediment toxicity tests provide important information for assessing the effects
       of contaminated sediments and aquatic organisms, including sediment-dwelling invertebrate
       species and fish. Based on the preceding evaluation of the applications of sediments toxicity
       test, the following recommendations are offered:

          •   Sediment toxicity testing should be included as an integral  element of most
              sediment quality assessments;
          •   Because  in situ  communities  of benthic  invertebrates  are  exposed  to
              contaminated sediments for extended periods of time, chronic toxicity tests are
              the most relevant for assessing effects on aquatic organisms;
          •   Due to their higher level of standardization and unequivocal relevance,  whole-
              sediment toxicity  tests should be preferentially included in  sediment  quality
              assessments; toxicity tests  involving  other media types (e.g., pore water) or

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                                      WHOLE-SEDIMENT AND PORE-WATER TOXICITY TESTING - PAGE 43
        exposures (e.g., in situ toxicity tests) should be included as projects objectives
        and resources dictate;

    •   Although a wide variety of aquatic species may be tested, the amphipod, Hyalella
        azteca, and midge, Chironomus tentans, are the most highly recommended for
        most freshwater sediment quality assessments;

    •   Both lethal (i.e., survival) and sub-lethal (e.g., growth, reproduction, emergence)
        endpoints should be measured in sediment toxicity tests;

    •   Whenever possible, a suite of sediment toxicity tests should be used to assess
        sediment quality conditions;

    •   All sediments evaluated with toxicity tests should be characterized for at least:
        pH and ammonia of the pore water; and, organic carbon content (TOC), particle
        size distribution (percent sand,  silt, clay),  and percent water content of the
        sediment (ASTM 200la;  USEPA  2000a).  Other  analyses  conducted on
        sediments can include:  biological oxygen demand;  chemical oxygen demand;
        cation exchange capacity; redox potential; total inorganic carbon; total volatile
        solids; AVS; metals; synthetic organic compounds; oil and grease; petroleum
        hydrocarbons; and, interstitial water analyses (ASTM 200la; USEPA 2000a).
        The concentrations of other COPCs should also be measured, as identified on the
        PSI (Chapter 3 of Volume II);

    •   If direct comparisons are to be made, subsamples for toxicity testing should be
        collected from the same sample for analysis  of sediment physical and chemical
        characterizations;

    •   Qualitative  descriptions of the sediment should include color, texture, and the
        presence of petroleum sheens, macrophytes, or animals. Monitoring the odor of
        sediment samples should be avoided due to the hazards associated with exposure
        to volatile chemicals;

    •   Following the selection of the most appropriate toxicity tests  for the specific
        application, the test procedures and DQOs should be described in the project
        QAPP;

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        The procedures for interpreting the sediment toxicity data should be described in
        the data analysis plan that is developed as part of the overall problem formulation
        process;

        The first step in the data interpretation process should involve evaluation of test
        acceptability (i.e., by comparing the results to the DQOs that were established in
        the QAPP);

        The results of sediment toxicity tests should be compared to those obtained for
        the negative control to evaluate test acceptability and/or to those obtained for
        appropriate reference sediment to assess the effect of contaminated sediment;
        and,

        Methods  for testing caged  organisms on site (i.e.,  in  situ  toxicity tests) are
        currently being developed by a variety of investigators (Crane and Maltby 1991;
        Veerasingham and Crane 1992;  Seager et al. 1991;  1992; Maltby and Crane
        1994; Crane et al.  1995a; 1995b; 1996; 1999; 2000; Sarda and Burton 1995;
        Ireland etal.  1996; Chappie and Burton 1997; Ohenetal. 2001). These methods
        have been used to evaluate the acute toxicity of sediments in the field. However,
        additional methods development and standardization is needed before these
        methods are applied routinely to evaluate the toxicity of contaminated sediments.
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                                            BENTHIC INVERTEBRATE COMMUNITY ASSESSMENT - PAGE 45
Chapter 4.    Benthic Invertebrate Community Assessment
4.0  Introduction

      The  structure of benthic invertebrate communities represents an important indicator of
      sediment quality conditions.  Such assessments are based on comparisons of community
      structure metrics, such as species richness, diversity, and the abundance of key taxa at test
      stations and appropriate reference stations (i.e., stations with similar depth, flow, sediment
      grain size, and TOC) and provide a means of assessing the COPC-related effects associated
      with exposure to sediments in the assessment area (USEPA 1992a; 1992b; 1994). Numerous
      studies have documented changes in the composition of benthic invertebrate communities
      resulting from sediment contamination (i.e., Rosenberg and Wiens 1976; Hilsenhoff 1982;
      1987; Clements etal. 1992). However, many of these studies have examined the responses
      of benthic invertebrates in stony riffle areas of streams and rivers, and provide only limited
      information on the assessment of soft sediments (which typically accumulate elevated levels
      of contaminants; USEPA 1994). This chapter is intended to describe the existing procedures
      for assessing benthic invertebrate data as part of an overall assessment of sediment quality
      in depositional freshwater habitats.
4.1  Selection of Metrics and Targets for Benthic Invertebrates
      Community Structure

      Benthic communities are assemblages of organisms that live in or on the bottom sediment.
      In most benthic community assessments, the primary objective is to determine the identity,
      abundance, and distribution of the species that are present (USEPA 1992a; 1992b; 1994).
      Because most benthic macroinvertebrates are relatively sedentary and are closely associated
      with the sedimentary environment, they tend to be sensitive to both short-term and long-term
      changes in habitat, sediment, and water  quality  conditions (Davis and  Lathrop 1992).

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 Therefore, data on the distribution and abundance of these species provide important
 information on the health of the aquatic ecosystem. As such, benthic invertebrate community
 structure represents an important ecosystem health indicator.

 Assessments  of benthic  community  structure  have been used to  describe reference
 conditions, to establish baseline conditions, and to evaluate the effects of natural  and
 anthropogenic disturbances (Striplin et al. 1992). In terms of evaluating sediment quality,
 such assessments are focused on establishing relationships between various  community
 structure metrics (e.g., species richness, total abundance, relative abundance of various
 taxonomic groups, macroinvertebrate  index of  biotic integrity; mlBI) and measures of
 sediment quality (e.g., chemical concentrations, and organic content).  Data from benthic
 community assessments have the potential to provide relevant information for identifying
 impacted sites and, with appropriate supporting data, the factors that are contributing to any
 adverse effects that are observed (USEPA 1992a; 1992b; 1994).

 The International Joint Commission (IJC 1988) suggested that benthic community surveys
 should be the first assessment tool used to evaluate areas of the Great Lakes with suspected
 sediment contaminant problems. If no effects are demonstrated in an initial survey, IJC
 (1988) recommended no further assessment. However, the absence of benthic organisms in
 sediment does not necessarily indicate that contaminated sediment caused the observed
 response. Benthic invertebrate distributions may exhibit high spatial or temporal variability.
 Furthermore, short-term exposure to chemical (e.g., ammonia, dissolved oxygen) or physical
 (e.g., temperature, abrasion) factors can influence  benthic invertebrate distribution  and
 abundance, even in the absence of measurable levels of COPCs in sediment.  Therefore,
 information on distribution of benthic invertebrates alone is not always indicative of ambient
 sediment quality conditions and is certainly not  diagnostic of sediment contamination or
 sediment toxicity (USEPA 1992a; 1992b; 1994).

 One objective of a benthic invertebrate community assessment is to  determine whether
 sediment-associated COPCs may be contributing to  a change in the distribution of benthic
 organisms in the field. These assessments can be used to measure interactive toxic effects
 of complex chemical mixtures in sediment. Furthermore, knowledge of specific pathways

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                                               BENTHIC INVERTEBRATE COMMUNITY ASSESSMENT - PAGE 47
       of interactions among sediments and test organisms is not necessary to conduct assessments
       of the benthic community. Assessments of the benthic invertebrate community can be used
       to:

          •  Determine the relationship between toxic effects and bioavailability;

          •  Investigate interactions among chemicals;

             Compare the sensitivities of different organisms;

          •  Determine spatial and temporal distribution of contamination;

          •  Rank areas for clean up; and,

          •  Evaluate the effectiveness of remediation or management practices.


       The results of benthic community assessments can also be used to assess the bioavailability
       of COPCs in field-collected sediments. The response of organisms collected from test sites
       are often compared to the response of organisms collected from reference sites. Reynoldson
       etal. (1995;  1997) and MacDonald and Ingersoll (2000) describe procedures for assessing
       benthic invertebrate community structure of sediment quality conditions.
4.2   Availability of Standard Methods
       Standard methods for evaluating effects of sediments on benthic community characteristics
       have not been established by organizations such as the ASTM. This lack of standardization
       has resulted in the use of a wide variety of techniques to evaluate the effects of contaminated
       sediments on benthic invertebrate communities (Rosenberg andResh 1993; USEPA 1992a;
       1992b; 1994). These techniques can be classified into four general categories based on the
       level of organization that is considered (Ingersoll etal. 1997; Table 14), including:

          •   Individual (e.g., morphological changes, biomarkers);

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          •  Population (e.g., abundance of keystone species; population size structure);

          •  Community structure (e.g., benthic index, multivariate analyses); and,

             Community function (e.g., energy transfer, functional groups).

       All of the various measurement endpoints are evaluated based on departure from an expected
       or predicted  condition  (such  as observations  made at  appropriate reference  sites).
       Uncertainty in the application of these techniques stems from incomplete knowledge of the
       system (i.e., what represents normal conditions); systematic error in the method being used;
       and, the sampling scale that is selected (Ingersoll etal. 1997). One of the major limitations
       of these techniques is associated with the difficulty in relating the observed effect to specific
       environmental stressors (e.g., contaminants vs. low  dissolved oxygen levels).  For this
       reason, benthic invertebrate community structure has typically not been considered to be a
       central indicator of sediment quality conditions.  However, such assessments may be
       conducted to provide ancillary information for further interpreting the sediment chemistry
       and toxicity data that are collected. Contingency tables have been developed for interpreting
       the results of sediment quality assessments that include multiple lines of evidence, including
       benthic invertebrate assessments (Chapter 7 of Volume HI). USEPA(1992a; 1992b; 1994)
       and ASTM (200 Ic) provide summaries of various  procedures used to sample benthic
       invertebrates from  sediments (i.e., grab samplers, artificial substrate samplers, dip nets;
       preservation and sorting of samples).
4.3   Advantages  and Disadvantages
       Benthic invertebrate community assessments have a number of advantages that make them
       useful for evaluating the impacts of contaminated sediments on sediment-dwelling organisms
       (Tablel5;USEPA1992a; 1992b; 1994). First and foremost, the results of these assessments
       provide information that is directly relevant for evaluating benthic invertebrate community
       status (i.e., evaluating the  in  situ effects  of contaminated sediments on the benthic
       community). In addition, procedures for conducting such assessments have been established

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 that facilitate  unbiased random sampling, support broad  geographic coverage of the
 assessment area (including both contaminated and uncontaminated areas), and reduce
 variability in the results (i.e., by sampling under consistent hydrological  and physical
 sediment conditions).  Furthermore, the information generated is socially-relevant (i.e.,
 benthic species represent important food organisms for many sportfish species, such as
 walleye) and can be used to discriminate between sites that are degraded to various extents.
 The spatial and temporal distribution of benthic organisms may reflect the degree to which
 chemicals in sediments are bioavailable and toxic. Field surveys of invertebrates can provide
 an important component of sediment assessments for several reasons:

    •  Benthic invertebrates  are abundant, relatively sedentary, easy to collect, and
       ubiquitous across a broad array of sediment types;

    •  Benthic organisms complete all or most of their life  cycle in the aquatic
       environment, serving as continuous monitors of sediment quality; and,

    •  Assessment of indigenous populations may be useful for quantifying resource
       damage.


 The  usefulness  of  field  studies  with benthic  invertebrates  for  assessing  sediment
 contamination has been limited by several factors including:

    •  The composition of benthic communities has been difficult to relate to the
       concentrations of individual chemicals;

    •  Benthic invertebrates respond to a variety of biotic and abiotic factors, in addition
       to COPCs;

    •  Large numbers  of samples  are typically needed to address the high variance
       associated with distribution of benthos (USEPA  1992a; 1992b; 1994);

    •  Limited standardized methods for collecting and processing samples; and,

    •  Inconsistencies in taxonomic identification of organisms.
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       Of primary concern, the information on benthic community structure can not be used alone
       to evaluate the cause of any impacts that are observed. While such communities certainly
       respond to chemical contamination in the sediment, they are also affected by a wide range
       of physical factors that are not directly related to sediment quality (e.g., low dissolved oxygen
       levels, grain size differences, nutritional quality of substrates, and water depth).  In addition,
       benthic community composition exhibits  significant spatial,  short-term temporal,  and
       seasonal variability; therefore, interpretation of the data relative to COPC-related effects can
       be difficult.  Care needs to be exercised to collect representative samples to minimize
       problems with data interpretation due to natural  variation.  For example, collection of
       samples should not be made after floods  or other physical disturbances than may alter or
       remove benthic community assemblages (USEPA 1992a). The selection of reference sites
       can  also influence the results of benthic community assessments.  To complicate matters
       further, there is little agreement among benthic ecologists on which metrics are the most
       appropriate for evaluating the status of the community as a whole.  Therefore, it is difficult
       to determine  if information  on  individual  organisms  (e.g., morphological  changes,
       biomarkers), populations of organisms (e.g.,  abundance of indicator species, population size
       structure), community structure (e.g., species richness, community indices), or community
       function (e.g., energy processing, presence of functional groups) should be used as indicators
       of benthic community status (Ingersoll et  al. 1997).
4.4   Evaluation of Data Quality
       Performance-based methods have been recommended for determining the acceptability of
       sediment toxicity  tests  (Chapter 3  of Volume III;  ASTM 200la;  USEPA 2000a).
       Unfortunately, similar types of performance-based methods have not been established to
       determine the acceptability of benthic community data. Nevertheless, a QAPP should be
       developed to  address the experimental design and sampling  procedures for the benthic
       community assessment (Chapter 5 and Appendix 3  of Volume  II).   The first step in
       conducting an evaluation of benthic invertebrate communities is the development of an
       appropriate experimental design  (USEPA 1992a;  1992b;  1994).   An  inappropriate

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 experimental design can be a major source of error in the resulting data.  There are many
 factors to be considered when sampling contaminated sediments for benthic invertebrates
 that differ from the considerations required for sampling  sediments for toxicity testing
 (Chapter 3 of Volume III). Benthic communities are strongly influenced by abiotic factors
 in the absence of COPCs, and in some cases, the effects of COPCs can be masked by effects
 of abiotic factors.  Important abiotic characteristics (i.e., sediment grain size, TOC, nutrient
 content, water quality, current velocity, and depth) at the site needs to be evaluated so that
 potential confounding effects  of these characteristics can be accounted for when data are
 analyzed and interpreted.  This holds  true whether the intent of the project is to make
 comparisons between upstream and downstream areas, between different aquatic systems
 (different lakes or rivers), or between seasons.

 When assessing benthic invertebrates for changes in community structure, it is critical to
 select appropriate reference sites (USEPA  1994; see Appendix 3 of Volume II).  Ideally,
 reference sites should be unaffected or minimally affected by  anthropogenic influences
 (ASTM 200Ic).   In  addition  to  having  low concentrations of COPCs in sediment, the
 reference sites should also have physical and chemical characteristics of both water and
 sediment that are similar to the site under investigation to minimize the potential effects of
 these characteristics on benthic invertebrates.

 Several studies have evaluated the number of replicate samples required to provide adequate
 assessments of benthic invertebrates (see USEPA 1992a; 1992b; 1994 for a listing of these
 publications). USEPA (1994) recommends that a sufficient number of replicate samples
 should be collected to achieve an among-sample coefficient of variation of less than 50%.
 Preliminary sampling at the sites  of interest should be conducted to determine the number
 of replicates required to achieve this obj ective. Depending on the types of taxa collected, the
 methods used to collect samples may need to be modified to more effectively sample benthos
 at the sites of interest. The results of this preliminary study can also be used to determine the
 lowest practical level of taxonomic identification of the species at the sites of interest
 (USEPA 1992a). The datamay notbe normally distributed; therefore, transformation of data
 may need to be made to determine the appropriate number of replicates (USEPA 1992a). In
 addition, the variance may be different for the different endpoints evaluated (i.e., number of

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       taxa vs. number of individuals). Previous studies have often collected three to five replicates
       per sampling station (USEPA  1992b;  1994).   The decision to collect this number of
       replicates is often based on funding and personnel constraints that limit the processing of a
       large number of samples. Although the collection of a smaller number of replicates may not
       invalidate the benthic invertebrate data,  such data should be interpreted with caution if the
       sites of interest are heterogeneous. USEPA(1992a; 1992b; 1994) include citations of several
       publications that more throughly address design of benthic invertebrate assessments.
4.5   Methodological Uncertainty
       A review of uncertainly  associated with the endpoints commonly measured in benthic
       invertebrate community assessments of sediment quality and approaches for addressing these
       sources of uncertainty was described in Ingersoll et al. (1997).  A series of criteria were
       established by Ingersoll et al. (1997) to support consistent assessments of the uncertainty
       associated with each measurement endpoint.  These evaluation criteria included: precision;
       ecological relevance; causality; sensitivity; interferences; standardization;  discrimination;
       bioavailability; and, field validation.

       The results of the evaluations of uncertainty associated with benthic community assessments
       are presented in Table 14. Uncertainty associated with lack of knowledge is indicated with
       an asterisk in this table to differentiate from systematic uncertainty which can be rectified
       (methodologically ) or quantified (sampling decisions and design).  Benthic invertebrates
       assessment methods were classified by Ingersoll et al. (1997) at different organizational
       scales, from the individual  to the community level (Table 14). The types of endpoints
       included at these different organizational scales include:

          •   Individual (e.g., morphological changes, biomarkers);

          •   Population  (e.g.,  indicator or keystone species  abundance, population size
              structure and life history modifications);
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    •   Community structure (e.g., indices, metrics, multivariate approaches); and,

    •   Community function (e.g., functional groups, energy transfer, size spectra).


 Although community function was considered, there is little information on its use and
 application in sediment assessment. Therefore, the degree of uncertainty associated with its
 use is high because of lack of knowledge (Ingersoll etal. 1997).

 The primary purpose of benthic invertebrate measurement metrics is to identify departure of
 the endpoint from either an expected or predicted condition, given normal variability in both
 time and space. Furthermore, these metrics should relate such a departure to a directional
 stressor.  The precision of a benthic community assessment decreases as the scale of
 organization increases; thus, measurement of community metrics tends to be less precise than
 measurement of metrics relating to individual organisms.  However, the uncertainty of
 measurements at the community level can be quantified and reduced by appropriate design
 and effort. Ingersoll et al. (1997) recommended that pilot studies be conducted to identify
 cost-effective benthic community metrics in relation to study objectives and  available
 resources to reduce or quantify  the uncertainty associated with problems  of precision.
 Ecological relevance in Table 14 refers to the relationship between the measured endpoint
 and the benthic ecosystem.  Accordingly, direct measures of the populations of organisms
 present have a higher certainty of being related to ecosystem than measurements  at a finer
 organizational scale.

 Measurements of benthic invertebrates provide little information with which to identify the
 specific COPCs or  stressors  that are causing the  response.   Ingersoll et al.  (1997)
 recommended that additional research be  conducted,  using controlled dose-response
 experiments, to evaluate the use benthic invertebrate data for identifying the toxic effects of
 specific COPCs in  sediments (e.g., Hayward 2002). The response of benthic invertebrates
 may be sensitive to COPCs in sediment, but it is difficult to separate out effects due to
 interferences  such  as grain size, TOC, depth, and water quality  characteristics of the
 overlying water at  the site of interest. Additional standardization and field validation of
 methods used to assess and interpret benthic community data would improve the application

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       of these approaches in sediment assessments, particularly in soft-bottom substrates where
       COPCs in sediments are of primary concern.
4.6   Interpretation of Data
       A variety of metrics are directly relevant for assessing benthic invertebrate community
       structure (USEPA 1992a; 1992b; 1994; MacDonald and Ingersoll 2000). Domination of the
       benthic invertebrate community by pollution-tolerant species, such as worms (oligochaetes,
       particularly tubificid oligochaetes) and midges (chironomids), has been considered to be
       indicative of degraded conditions (i.e., for grab samples; MacDonald and Ingersoll 2000).
       The absence of more sensitive organisms, such as amphipods and EPT taxa (Ephemeroptera -
       mayflies, Plecoptera - stoneflies, and Tricoptera - caddisflies)  has also been considered to
       provide  strong  evidence  that benthic habitats and  associated communities  have been
       degraded, particularly in hard-bottom substrates, such as riffles (OEPA 1988a; 1988b; 1989).
       Additionally, mffil scores were used to determine if benthic macroinvertebrate communities
       had been degraded relative to  unimpacted sites (i.e.,  for artificial substrate  samples;
       MacDonald and Ingersoll  2000).  Information from studies on the colonization of benthic
       invertebrates on artificial  substrates and from  assessments of in situ benthic invertebrate
       community status can also be  used to assess benthic invertebrate community  structure
       (USEPA 1992a; 1992b; 1994).

       In general, sediment quality targets for the various metrics relating to benthic invertebrate
       community structure can be established by assembling relevant information from relatively
       uncontaminated reference sites. For example, Ohio Environmental Protection Agency has
       established  biocriteria applicable to the benthic community for a variety of ecoregions in the
       state using this reference site approach (OEPA 1988a; 1988b; 1989). Likewise, Simon et al.
       (2000) established a state-wide model for assessing benthic invertebrate community structure
       in Indiana using the mffil, which provides a basis for establishing sediment quality targets.
       In this respect, Reynoldson et al. (1995) recommended  that the normal range of benthic
       invertebrate community metrics be established using the 95% prediction limits;  sediment

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 quality targets could then be established as the upper and/or lower limits of the normal range
 for each metric (Reynoldson et al. 1997; Reynoldson and Day  1998;  Reynoldson and
 Rodriguez 1999).

 Benthic community assessments are required to support three distinct aspects of the sediment
 quality assessment process. First, benthic community assessments may be required to assess
 the effects of contaminated sediments at stations where the concentrations of one or more
 COPCs is elevated above threshold  SQGs (e.g.,  PECs).  Second, benthic community
 assessments may be required to assess the effect of sediments that could contain unmeasured
 substances. Third, benthic community assessment data may be required to assess the site-
 specific applicability of the SQGs. In this respect, additional data  on  sediment toxicity
 (Chapter 3 of Volume ID) and on benthic community assessments may be needed when the
 forms of the COPCs that are present may be less biologically available than those at other
 sites (i.e., the data used to support predictive ability evaluation of SQGs; USEPA 2000a).

 The steps that should be used to assess benthic invertebrate community status are outlined
 in Figure 4.  Once benthic community data  have been assembled, the quality of the data
 needs to be determined using criteria outlined in Section 4.4 of Volume III. If the benthic
 community data do not meet the quality needed  for the assessment, it may be necessary to
 repeat certain components of the sampling and analysis program. The assessment of benthic
 community data consists primarily of comparing the response of individual metrics (i.e.,
 number of taxa or an index) measured at test stations to those measured for appropriately
 selected reference stations (Figure 4). Test stations that are found to statistically differ from
 reference stations are classified as having a degraded community.  These comparisons may
 be based on ANOVA, multivariate, or nonparametric statistical analyses (USEPA 1992a;
 1992b; 1994).
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4.7   Recommendations

       The results of benthic invertebrate community assessments can provide useful information
       for evaluating the effects of contaminated sediments on sediment-dwelling organisms. Based
       on the preceding evaluation  of the applications of benthic invertebrate assessments, the
       following recommendations are offered:

          •  Historically, sediment chemistry andtoxicity data represent the primary elements
             of most  routine  sediment quality  assessments.   In  some  cases,  benthic
             invertebrate assessments have complemented these data by providing a basis for
             validating the results  of such evaluations;

             The metrics that provide information on the status of the benthic invertebrate
             community (e.g., abundance of sensitive and tolerant taxa, species diversity,
             species richness, mlBI) are the most relevant for assessing sediment quality
             conditions;

          •  USEPA (1994) recommended a tiered approach for assessing benthic invertebrate
             communities. The first tier should include a qualitative preliminary survey of
             each study area  to: (1) determine if community structure indicates alterations
             relative to reference conditions; (2) evaluate if there are differences in community
             structure across spatial gradients that may identify hot spots of contamination; (3)
             determine if taxa are represented by several orders of organisms or if the
             community is skewed toward a limited number of orders of organisms; and, (4)
             determine the number of replicate samples needed for the second tier of the
             assessment.  Results from this first-tier assessment can be used to identify the
             best methods for sampling organisms at the sites of interest.  The second tier
             should then include a  quantitative  survey that allows for a more robust statistical
             analyses of the various metrics chosen for the assessment;

          •  In order to interpret impacts on benthic invertebrates, it is critical to sample a
             number of reference stations that bracket the range in physical characteristics of
             the test stations. The physical characteristics that should be considered when


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                                          BENTHIC INVERTEBRATE COMMUNITY ASSESSMENT - PAGES?
        selecting a range of appropriate reference  stations  include  sediment TOC,
        sediment grain size, water depth, water current, and water quality at the station;

    •   Benthic invertebrate community assessments should be designed to collect an
        adequate number of replicate samples from both reference and test  sites to
        characterize within site variability;

        The procedures that are to be used to collect  samples and to identify and count
        invertebrates should be documented in the QAPP;

    •   ASTM (200la) and USEPA (2000a) recommend that all  sediments evaluated
        with toxicity tests should be characterized for at least:  pH and ammonia of the
        pore water; organic carbon content (TOC);  particle size distribution (percent
        sand, silt, clay); and, percent water content.  Other analyses on sediments can
        include: biological oxygen demand; chemical oxygen demand;  cation exchange
        capacity; oxidation reduction potential; Eh; total inorganic carbon; total volatile
        solids;  AVS; metals; synthetic organic compounds;  oil and grease; petroleum
        hydrocarbons;  and, interstitial water analyses (ASTM 200la; USEPA  2000a).
        These physical and chemical  characterizations of sediments are also relevant
        when collecting benthic community data at a site;

        Qualitative descriptions of the sediment may include color, texture, and presence
        of petroleum sheens, macrophytes, or animals. Monitoring the odor of sediment
        samples  should be avoided due to the hazards associated with exposure to
        volatile chemicals;

        The procedures for interpreting the results of the benthic invertebrate community
        assessments should be described in the data analysis plan that is developed as part
        of the overall problem formulation process;

        The first step in the data interpretation process should involve evaluation of data
        acceptability (i.e., based on the data quality obj ectives that were established in the
        QAPP);

    •   The results obtained for test sites should be compared with the results obtained
        for appropriately selected reference sites [i.e., uncontaminated sites which have

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        similar physical (e.g., grain size, water depth), and chemical (e.g. dissolved
        oxygen) characteristics as the test sites];

        Models have been developed for use in predicting expected distributions of
        benthic invertebrates  at  stations in  the  absence of sediment  contamination
        (Reynoldson et al. 1994). If these models are used, it is important to determine
        if the database used to develop the  models is representative of the physical
        characteristics of the test  stations being evaluated; and,

        Unlike the results  of assessments conducted using sediment chemistry data,
        benthic invertebrate assessments  alone  should  not be used to definitively
        determine sediment quality (USEPA 1992a).  Again, the results of benthic
        invertebrate assessments should be considered in conjunction with the results of
        the  companion  measures  of  sediment chemistry, sediment  toxicity,  and
        bioaccumulation that are conducted  at the assessment  area (see Chapter 7 of
        Volume III).
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Chapter 5.    Bioaccumulation Assessment


5.0  Introduction

      In aquatic ecosystems, many substances that occur at only trace levels in overlying water can
      accumulate to elevated levels in sediments. The same physical-chemical properties that
      cause these substances to accumulate in sediments (e.g., low aqueous solubilities, high Kow),
      make chemicals such as PCBs, OC pesticides, and mercury prone to bioaccumulation. The
      accumulation of such substances in the  tissues of  sediment-dwelling organisms and
      subsequent biomagnification in aquatic food webs can pose risks to a variety of ecological
      receptors, particularly those organisms that consume  aquatic species.  Bioaccumulation
      assessments are conducted to provide the information needed to assess the risks to aquatic-
      dependent wildlife and  human  health associated with exposure to bioaccumulative
      substances.  This chapter is intended to  describe  the procedures  for bioaccumulation
      assessments as part of integrated  assessments, which represent important components of
      integrated assessments of sediment quality conditions.
5.1  Selection of  Metrics  and  Targets  for  Bioaccumulation
      Assessment

      Contaminated sediments represent important sources of the substances that accumulate in
      aquatic food webs (Ingersoll et al. 1997). Because these contaminants can adversely affect
      aquatic-dependent wildlife species and/or human health,  tissue chemistry represents an
      important ecosystem health  indicator in sediment  quality assessments (ASTM 200Id;
      USEPA 2000a). In general, the concentrations of COPCs in the tissues of sediment-dwelling
      organisms represent the primary metrics for tissue chemistry. As wildlife species typically
      consume the entire prey  organism, whole body COPC levels are the most relevant for
      assessing risks to wildlife. In contrast, the levels of COPCs in edible tissue represents the
      most important metrics for human health assessments.  Assessments that are directed at

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 evaluating COPC residues in the tissues of benthic macroinvertebrates should focus on the
 bioaccumulative COPCs that are known or suspected to occur in sediments at the site under
 investigation.  Typically, the COPCs that are considered in such assessments include:
 metals, methyl mercury, PAHs, PCBs, OC pesticides, chlorophenols, and/or PCDDs/PCDFs.
 However, this list should be refined based on the land and water use activities that have been
 documented in the vicinity of the site.

 The selection  of species for  inclusion  in  assessments  of bioaccumulation  requires an
 understanding of the predator-prey relationships in the ecosystem under investigation. For
 example, the levels of COPCs in benthic macroinvertebrates are likely to be relevant when
 evaluating risks associated with dietary uptake  of COPCs by  bottom-feeding fish or
 sediment-probing birds.  Conversely, emergent insects may be the primary  focus of an
 investigation  if swallows represent the primary  receptor of concern. In cases where
 fish-eating birds and mammals represent the wildlife species of special concern, fish would
 be the primary species targeted in sampling and analytical programs. In this way, sampling
 programs can be tailored to answer the key risk questions that  are being posed by the
 investigators. Bioaccumulation is not an appropriate assessment approach for  COPCs that
 are rapidly metabolized or otherwise not accumulated in the tissues of the organism(s) being
 evaluated.

 Ingersoll et al. (1997) identified four general approaches for conducting bioaccumulation
 assessments, including:

    •  A laboratory approach, which involves exposing organisms to sediment under
       controlled conditions;

    •  A field approach which involves  collecting organisms from a study area;

    •  Assessment of food web transfer; and,

    •  Models to predict bioaccumulation processes.


 The following sections briefly describe each of these approaches.

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 In the laboratory approach, individuals of a single species are exposed under controlled
 laboratory conditions to sediments collected from the study area being assessed (ASTM
 200 Id; USEPA2000a).  After an established period of exposure, the tissues of the organisms
 are analyzed for the COPCs.  Bioaccumulation has occurred if the final concentration in
 tissues exceeds concentrations  that were present before the exposure was started.  This
 requires that individuals representative of initial conditions also be analyzed. This approach
 has been  routinely applied in the assessment of contaminated sediments (ASTM 200Id;
 USEPA 2000a).

 In the field approach, concentrations of COPCs in tissues are determined by collecting one
 or more  species  exposed to  sediments at the  study area being assessed.  In addition,
 organisms representing various trophic levels may be collected and analyzed to determine
 tissue residue levels. These concentrations are compared to those that have been measured
 in the tissues of organisms collected from appropriately selected reference area(s).  Two
 methods have been used to determine bioaccumulation in the field:

    •   Organisms resident at the area are collected in situ for analysis; or,

    •   Organisms are transplanted from another location (presumably with a history of
       little contaminant exposure) to the area of concern then re-collected, and tissues
       are analyzed after an established period of exposure.


 These approaches have not been used routinely in the assessment of contaminated sediments
 (ASTM 200Id).  In some cases, semipermeable membrane devices (SPMDs) are deployed
 in the field for specified time periods to simulate exposures of aquatic organisms to COPCs
 (Williamson et al. 2002).

 Models which describe bioaccumulation are relatively well developed for both organic and
 inorganic  contaminants (Thomann 1989; Luoma and Fisher 1997; ASTM  200Id).
 Toxicokinetic models have a long history,  as do  simpler models of bioaccumulation
 processes.  Site-specific models predict bioaccumulation on  the basis  of laboratory-
 determined characterization of biological processes in the species of interest and field-

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       determined chemical measurements at the area of concern.  Some uncertainties remain
       unresolved in most models and consensus does not exist about the appropriate model to
       apply for some (if not all) COPCs (Luoma and Fisher 1997).

       Equilibrium models are commonly employed in risk assessment of bioaccumulation and are
       available for both organic and inorganic COPCs (Di  Toro et al. 1991; Ankley et al.  1996).
       The models assume  that the  concentrations of COPCs  among  all compartments of the
       environment are controlled by thermodynamics and at least approach equilibrium conditions.
       If thermodynamic equilibrium exists and if one route of uptake is known or can be predicted,
       overall bioaccumulation is inferred. Recent applications use an extension of the equilibrium
       models,  termed kinetic or pathway models (ASTM 200Id).  These models incorporate
       geochemical principles and also address uncertainties in the assumptions of equilibrium.
       Kinetic models assume that routes of bioaccumulation are additive and must be determined
       independently.  Kinetic models and equilibrium models may yield similar results if COPC
       distributions and concentrations in an environment are at equilibrium (although not always),
       but can yield very different results where environmental compartments are not at equilibrium
       (e.g., if biological processes control concentrations, speciation,  or phase partitioning of
       COPCs;  Ingersoll et al. 1997).

       Tissue residue guidelines for the protection of piscivorus wildlife species and/or human
       health represent the principal targets that are used to interpret the results of bioaccumulation
       assessments. However, a variety or risk-based procedures have also been developed to
       evaluate the results of such assessments. These tools can also be used to back-calculate to
       the concentrations of COPCs in sediment that will  protect human health and  ecological
       receptors.
5.2   Availability of Standard Methods
       Standard methods have been developed for conducting whole-sediment bioaccumulation
       tests with a variety of test organisms, including the oligochaete Lumbriculus variegatus

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 (ASTM 200Id; USEPA 2000a) and the amphipod Diporeia spp. (ASTM 200Id).  The
 Organization for Economic Cooperation and Development (OECD) is in the process of
 developing standard methods  for  conducting sediment  bioaccumulation tests  with
 Lumbriculus variegatus. ASTM (2001 d) also describes procedures for conducting sediment
 bioaccumulation tests with midges (Chironomus tentans and Chironomus riparius) and the
 amphipod (Hyalella  azteca); however, Lumbriculus variegatus or  Diporeia spp. are
 recommended in ASTM (200Id) for routine bioaccumulation testing with sediments.

 The following  criteria, which are outlined in Table 16, were used to  select Lumbriculus
 variegatus for bioaccumulation method development (ASTM 200Id; USEPA 2000a):

    •   Ease of culture and handling;

    •   Known chemical exposure history;

    •   Adequate tissue mass for chemical analyses;

        Tolerance of a wide range of sediment physico-chemical characteristics;

    •   Low sensitivity to contaminants associated with sediment;

    •   Amenability to long-term exposures without feeding;

    •   Ability  to accurately reflect concentrations of contaminants in field-exposed
        organisms (i.e., exposure is realistic); and,

    •   Data is available confirming the response of laboratory  test  organisms with
        natural  benthic populations.


 Thus far, extensive inter-laboratory testing has not been conducted with Lumbriculus
 variegatus. Other  organisms that did not meet many of these selection criteria (i.e., as
 outlined in Table 16) included mollusks (valve closure), midges (short-life cycle), mayflies
 and Diporeia (difficult  to culture), amphipods (Hyalella azteca; small tissue mass, too
 sensitive), cladocerans, and fish (not in direct contact with sediment).
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 Sediments for bioaccumulation testing may be either collected from the field or spiked with
 a range of concentrations of one or more COPCs. Recommendations are provided in ASTM
 (200Id)  concerning  procedures  for meeting  differing  study objectives  in  sediment
 evaluations. These recommendations address the following: sediment physical and chemical
 measurements; test organism selection,  collection, and  maintenance;  construction and
 maintenance of exposure systems; sampling methods and test durations; models that may be
 used to predict bioaccumulation; and statistical design of tests and analysis of test data.

 The  procedures  outlined  in  these standard methods  can  be modified  to  assess
 bioaccumulation of contaminants in sediment by other benthic invertebrate species that occur
 in freshwater environments.  However, the results of tests, even those with the same species,
 using procedures different from those described in the ASTM (200Id) and USEPA (2000a)
 may not be comparable, as using different procedures may alter the bioavailability of COPCs.
 If tests are conducted with procedures different from those described in ASTM (200 Id) or
 in USEPA (2000a), additional tests are  required to determine comparability of results.
 Comparison of results obtained using modified versions of these procedures might provide
 useful information concerning new concepts and procedures for conducting sediment tests
 with aquatic organisms.

 The procedures described in these standard  methods are designed to generate quantitative
 estimates of steady-state tissue residue levels, which are commonly used in  ecological or
 human health risk assessments. Eighty percent of steady-state concentrations of sediment-
 associated COPCs is used as the general criterion for bioaccumulation tests.  Because the
 results from a single or few  species are often extrapolated to other species, the procedures
 are  designed to maximize exposure to sediment-associated COPCs so that residues in
 untested species are not systematically underestimated. A 28-day bioaccumulation test with
 sediment-ingesting invertebrates, which are provided with no  supplemental food, is
 recommended as the standard exposure scenario (ASTM 2001 d; USEPA 2000a). Procedures
 for  conducting long-term and kinetic tests  are  recommended for  use  when 80% of
 steady-state is unlikely to be obtained within  28 days or when more precise estimates of
 steady-state tissue residues are required (ASTM 200Id).  The procedures are adaptable to
 shorter exposures and different feeding types.  Exposures shorter than 28 days may be used

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       to identify which compounds are bioavailable (that is, bioaccumulation potential) or for
       testing species that do not live for 28 days in the sediment (for example, certain species of
       midge such as Chironomus tentans or Chironomus riparius).  Non-sediment-ingestors or
       species requiring supplementary food may be used if the objective is to determine uptake in
       these  particular species due  to their  importance in ecological  or human health risk
       assessments. However, the results obtained for such species should not be extrapolated to
       other species.
5.3   Advantages and Disadvantages
       The strengths of using tissue chemistry data for evaluating the effects of contaminated
       sediments on sediment-dwelling organisms are similar to those that were cited for sediment
       chemistry data  (Chapter  2 of Volume HI; Table  17).  These  advantages  include the
       availability of standard methods for quantifying contaminant concentrations in tissues, and
       of procedures for evaluating the accuracy and precision of the resultant data.  Importantly,
       tissue chemistry data can be used to reliably identify the substances that are accumulating in
       the tissues of sediment-dwelling  organisms and, as a result, causing or  substantially
       contributing to sediment  toxicity.  Standard methods have  also  been developed for
       conducting bioaccumulation tests in the laboratory with sediments (ASTM 200Id; USEPA
       2000a).

       There are a number of factors that can limit the applicability of tissue chemistry data in
       sediment quality assessments. First, generation of high quality tissue chemistry data often
       requires a substantial mass of tissue to support analyses for the various COPCs. Collection
       of sufficient numbers of organisms to support such analyses can be challenging, particularly
       in highly contaminated sediments which typically have depauperate benthic communities.
       In addition, interpretation of such data is dependent on the availability of benchmarks that
       link tissue residue levels to adverse effects in sediment-dwelling organisms.   The use of
       inappropriate  analytical methods  (i.e.,  with high reporting limits), the  presence of
       interferences, and inadequate quality assurance practices can limit the utility of the resultant

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 data. See ASTM (200 Id) and USEPA (2000a) for a more complete description of potential
 interferences associated with conducting sediment bioaccumulation tests in the laboratory.

 Tissue chemistry data provide important information for identifying the substances that are
 accumulating in biological tissues. However, these data cannot, by themselves, be used to
 assess risks or hazards to  sediment-dwelling  organisms.   Interpretation of these data
 necessitates the establishment of targets that define the levels of COPCs that are unlikely to
 adversely effect sediment-dwelling organisms.  Bioaccumulated substances may cause an
 adverse  effect on either the organism accumulating the material or  an organism  that
 consumes the contaminated tissue. While numerical TRGs are notyet available for assessing
 the direct effects of contaminant residues in benthic macroinvertebrates, Jarvinen and Ankley
 (1999) recently published  a database that links tissue residues  to effects  on aquatic
 organisms.  The United States Army Corps of Engineers has developed a similar database
 (Environmental Residue-Effects Database), which is available on the organization's website
 (http://www.wes.army.mil/el/ered/index.html).  The information that is  contained in these
 databases can be used to help identify toxicity thresholds (i.e., targets for tissue chemistry)
 for  the  various  COPCs at the  site under investigation.    Subsequent comparison of
 field-collected tissue residue data to the published toxicity thresholds provides a basis for
 determining if bioaccumulative substances are present in the tissues at levels that are likely
 to adversely affect sediment-dwelling organisms.

 The effects on aquatic-dependent wildlife associated with dietary exposure to tissue-borne
 contaminants are typically evaluated using numerical TRGs  or toxicity reference values
 (TRVs) for tissues. In both cases, the measured concentrations of COPCs in the tissues of
 aquatic organisms are compared to the levels that have been established to protect piscivorus
 wildlife (TRGs; Newell et al. 1987) and/or the levels that are associated with specific types
 of adverse effects (TRVs; Sample et al. 1996). The potential for adverse effects on human
 health associated with the consumption of contaminated fish and/or invertebrate tissues can
 be evaluated using the Action Levels that have been established by the Food and Drug
 Administration (USEPA  1989).   The availability  of such benchmarks  to support
 interpretation of the data represents an important advantage of the bioaccumulation approach.
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5.4   Evaluation of Data Quality
       The  use of  performance-based  methods  has been recommended  for  laboratory
       bioaccumulation testing (ASTM 2001 d; USEPA 2000a). Performance-based methods permit
       the use of methods that meet pre-established performance standards (Chapter 3 of Volume
       III). The experimental design and sampling procedures for the bioaccumulation analyses
       should be documented in the proj ect QAPP. Two primary issues related to quality of the data
       in bioaccumulation assessments include detection limits and replication.  Detection limits
       for tissue analyses selected for the assessment should depend on the objectives of the study
       and the benchmarks for assessing potential effects (Section 5.6  of Volume III).  ASTM
       (2001d) and USEPA (2000a) describe procedures for determining adequate tissue mass for
       the selected detection  limits and minimum detectable differences among treatments.  For
       example, ASTM (200Id) and USEPA (2000a) recommend a minimum of 1 g per replicate
       and preferably 5 g per  replicate in bioaccumulation tests with the oligochaete Lumbriculus
       variegatus; five replicates per treatment were also recommended. Methods for achieving low
       detection limits for a variety of organic and inorganic compounds can be found in Ankley et
       al.  (1992), Brunson et al.  (1998), ASTM  (2001 d)  and USEPA (2000a). Methods for
       achieving low detection limits for lipid analyses  in small tissue samples can be found in
       Gardner et al. (1985),  ASTM (2001d), and USEPA (2000a).

       The decision to depurate the gut contents of organisms before chemical analysis is dependent
       on the objective of the study. If the objective of the study is to determine the total dose of
       contaminants in prey organisms that could be transferred to a predator, then test organisms
       should not be depurated before analyses of body burden. However, if the objective of the
       study is  to determine a steady-state concentration of compounds in  an organism, then
       organisms are typically depurated. See ASTM (200Id) and USEPA (2000a) for a discussion
       of approaches that can be used to estimate the contribution of contaminants in the gut to the
       overall body burden of contaminants in an organism.

       Performance-based procedures have been established in ASTM (2001 d) and USEPA (2000a)
       for establishing the acceptability of a laboratory bioaccumulation test. For example, Table
       18 outlines a method for conducting 28-day sediment bioaccumulation exposures with the

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       oligochaeteLumbriculus variegatus, while Table 19 lists the test acceptability requirements
       for conducting this test (ASTM 200Id; USEPA 2000a).  The primary requirements for
       meeting test acceptability of organisms in this sediment exposure include behavior (i.e.,
       organisms should not avoid the sediment) and toxicity (survival of organism should not be
       reduced relative to the control sediment), maintenance of water quality characteristics of the
       overlying water during the exposure, documentation on the quality of the cultures used to
       obtain  organisms for testing (organisms at the  start  of the exposure  should have low
       concentrations of COPCs), maintenance of the exposure system, and handling of sediments
       for testing (Table  19).  Additional quality  assurance and quality control procedures for
       conducting sediment toxicity tests are outlined in ASTM (200Id) and USEPA (2000a).
5.5   Methodological Uncertainty
       In a review of uncertainty associated with endpoints commonly used in bioaccumulation
       assessments, Ingersoll et al. (1997) identified four general approaches for bioaccumulation
       assessments, including:

          •  A laboratory approach, which involves exposing organisms to sediment under
             controlled conditions;

          •  A field approach, which involves collecting organisms from a study area;

          •  Assessment of food web transfer; and,

          •  Models to predict bioaccumulation processes.


       Each of these approaches was evaluated in Ingersoll et al. (1997) in relation to following
       major sources  of  uncertainly:  precision, ecological  relevance, causality, sensitivity,
       interference, standardization, discrimination,bioavailability, and field validation (Table 20).
       Precision was evaluated in terms of the replicability the particular measurement.  Ecological
       relevance was evaluated in terms of its linkage to the receptors which are to be protected.

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 Causality was evaluated relative to the ability of the measure to determine the factors that
 adversely affect organisms exposed to contaminated sediments. Sensitivity was evaluated
 relative to the ability of the measure to identify sediments that have the potential to affect
 sensitive species in aquatic ecosystems. Interferences were evaluated related to biotic or
 abiotic factors which could influence the response of the measurement beyond the direct
 effects of specific contaminants.  Standardization was evaluated in terms of the level of peer
 review and publication of standard methods.  Discrimination was evaluated in terms of
 whether or not a graded response could be identified. Bioavailability was evaluated relative
 to the ability of the measure to determine the fraction of contaminants in  sediment readily
 available to organisms. Finally, field validation was established relative to how the measure
 has been used to predict responses of benthic communities in the field.

 Variability  is a  common problem in bioaccumulation studies and can lead to  imprecise
 estimates of exposure.  However, standard methods  for determining  bioaccumulation
 describe procedures  for avoiding extreme  sources of uncertainty (ASTM 200Id; USEPA
 2000a).    Laboratory  bioaccumulation  tests  are  potentially   the  most precise  of
 bioaccumulation approaches.  However, their precision is directly dependent upon biological
 factors, such as the selection of appropriate test organisms.  Number of individuals sampled,
 number of composites, life-stage, size of organisms, biases from analysis  of gut  content or
 surface  contamination  are examples of uncertainty associated with field approaches.
 Bioaccumulation models were ranked as imprecise because of the large  knowledge gaps
 which remain in identifying values for model parameters (Table 20).

 Ecological relevance includes both relevance to ecological change and relevance to human
 exposure pathways. A limitation to the bioaccumulation approach is its weak link to adverse
 ecological  effects.   Bioaccumulation does not mean an  adverse effect  is   occurring.
 Organisms  are capable of detoxifying, adapting to or otherwise surviving some dose of
 COPCs. Correlations between bioaccumulated COPCs and effects on sediment-dwelling
 organisms are also not as well  established  (Jarvinen and Ankley 1999).  Collection of
 organisms exposed in the field, food web bioaccumulation estimates, and empirical and site-
 specific  models provide direct  determination of contaminant concentrations  in aquatic
 resource (food) species and provide information for pathways of human exposure. Where

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 tissue concentrations are directly determined in the food organism, there is little uncertainty
 about relevance. The precise human exposure pathway is predicted with less certainty if
 analyses of a surrogate species are used to estimate human exposures from a variety of
 species in an environment.

 Causality describes the linkage between the source of the COPCs, exposure pathways, and
 the measured biological effect.  Bioaccumulation  data alone cannot provide information
 about whether the source of exposure was overlying water or sediment, and cannot be used
 alone to  evaluate  effects  of contaminants on aquatic  organisms.    Nevertheless,
 bioaccumulation data provide the  strongest endpoints for drawing  linkages to COPCs
 because it involves direct determinations of the concentrations of those substances in tissues.
 Bioaccumulation is  a sensitive response because it measures exposure of an organism to
 relevant COPCs. However, bioaccumulation is not appropriate for determining exposures
 to ammonia or certain metals, which are not bioaccumulated before exerting toxic effects.
 In addition, model results will be fraught with uncertainty about sensitivity until widely
 accepted input parameter values are established (Table 20).

 Interferences can add uncertainties to bioaccumulation studies. Sediment characteristics are
 an important source of uncertainty in laboratory bioaccumulation studies because collection,
 transport, and deployment can change sediment characteristics from conditions in the field.
 It is possible that variability over small spatial scales interferes with or adds  uncertainty to
 discrimination between  areas on larger scales.  Use of standard methods for field and
 laboratory bioaccumulation assessments can reduce uncertainty (ASTM 200Id;  USEPA
 2000a).

 The ability of bioaccumulation to discriminate contamination gradients with low uncertainty
 is one of its advantages.  Inherently, bioaccumulation is a highly quantitative approach for
 discriminating the risk of exposure to COPCs from a sediment. Bioaccumulation directly
 measures bioavailability in both laboratory  and field studies. Some qualitative uncertainty
 in  bioavailability (if it is defined  as COPCs  assimilated into tissues)  can occur in
 determination of whole-tissue concentrations. Undigested gut content can be analyzed as
 part of the tissue burden and cause systematic uncertainties (upward bias) in estimates of

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       bioavailability if COPC concentrations in food are high compared to tissues (and if food
       mass in the gut is sufficiently great).  COPCs in gut content and on animal surfaces will be
       consumed by predators, so there is not a widespread consensus about the necessity of purging
       all undigested COPCs from the gut of organisms.  Some studies, especially with small
       organisms, have successfully related bioaccumulation obtained in the laboratory with field-
       collected sediments to residue concentrations observed in synoptically collected organisms
       from the field (Ankley et al. 1992; Brunson et al. 1998;  Ingersoll et al. 2003).

       In summary, the principal use of bioaccumulation is to estimate the exposure or dose which
       organisms encounter in  a sediment  (Ingersoll et al. 1997).   Bioaccumulation  is not an
       appropriate assessment approach for COPCs which are rapidly metabolized or, for other
       reasons, are not accumulated in the tissues of the organism(s) being evaluated.  Another
       limitation of the  bioaccumulation  endpoint is its weak  link to  ecological effects.
       Bioaccumulation does not mean  an  adverse  effect is  occurring.    The relevance of
       bioaccumulation stems mainly from its value in characterizing exposures and understanding
       the dose that an organism experiences.  This can be especially valuable information if used
       to expand understanding of bioavailability or if exposures are complex in space or time (as
       is often the case) at the site of interest. Bioaccumulation can be a highly variable endpoint,
       but if established methods are followed and sample size is adequate, variability, imprecision,
       and insensitivity can be controlled.
5.6   Interpretation of Data

       Interpretation of tissue chemistry data relative to the potential for adverse effects on aquatic-
       dependent wildlife necessitates the establishment of targets that define tolerable levels of
       COPCs in the tissues of aquatic organisms. More specifically, such data may be compared
       to TRGs to determine if COPCs have accumulated in the tissues of aquatic organisms to such
       an extent that adverse effects on piscivorus wildlife species are likely to occur. Such TRGs
       for the protection of piscivorus wildlife have been developed  by the New York State
       Department of Environmental Conservation (Newell et al.  1987). Toxicity thresholds for

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 wildlife species have also been established to support interpretation of field and laboratory
 data (Sample et al.  1996).

 The consumption of contaminated tissues represents the most important route of human
 exposure to bioaccumulative COPCs at sites  with  contaminated  sediments.  Fish
 consumption advisories are frequently established  as  a  result of bioaccumulation  of
 sediment-associated contaminants by fish (Beltman and Lipton 1998). USEPA has published
 guidance on the use of chemical contaminant data in the development offish consumption
 advisories (USEPA 2000d).  For this reason, tissue chemistry represents an important
 ecosystem health indicator for assessing effects  on  human health.   Application of this
 ecosystem health indicator necessitates the identification  of appropriate metrics that can be
 used to evaluate the status of this indicator. A list of target analytes for biological tissues can
 be developed from the preliminary list of COPCs for the  site (i.e., that is established using
 background  information on the  site) by identifying the  substances that are likely  to
 accumulate in  biological tissues (e.g., mercury, certain  PAHs,  PCBs,  organochlorine
 pesticides, PCDDs).

 Evaluation of the actual hazards posed by bioaccumulative substances requires information
 on the levels of contaminants that are present in fish and shellfish tissues, on the weekly
 consumption of contaminated tissues by various sectors of the population, and on the toxicity
 of each COPC  to mammalian receptors. Alternatively, TRGs can be used, in conjunction
 with tissue residue data,  to  determine if existing  concentrations of bioaccumulative
 substances pose a potential hazard to human consumers.

 Interpretation of tissue chemistry data relative to the potential for adverse effects on human
 health necessitates the establishment of targets that define tolerable levels of COPCs in the
 tissues of aquatic organisms.  In this context, numerical TRGs provide a basis for assessing
 sediment injury relative to human health. The Action Levels that have been established by
 the U.S. Food and Drug Administration (USEPA 1989) provide benchmarks for assessing
 the quality  of  fish  tissues.  Additionally, the presence  of fish or wildlife  consumption
 advisories provides direct evidence that the beneficial uses of the aquatic ecosystem have
 been compromised  (i.e., the target for fish consumption advisories would be zero).

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 Information on levels of contaminants in aquatic biota and on bioaccumulation supports
 determination of the significance of COPC levels in sediments relative to the direct toxic
 effects on these organisms or relative to protection of human health and the health of wildlife
 that consume these aquatic organisms.  Equilibrium-partitioning models and kinetic models
 can also predict the accumulation of both organic and inorganic COPCs from sediment by
 aquatic organisms (ASTM 200Id).

 Interpretation of tissue residue data is challenging for a number of reasons.  While many
 aquatic organisms are sedentary (i.e.,  infaunal invertebrate species), others can be highly
 migratory (i.e., fish). For migratory species, it can be very difficult to establish where the
 exposure to bioaccumulative COPCs actually  occurred. In addition, the concentrations of
 tissue-associated COPCs can vary depending on the trophic status, reproductive status, age,
 tissue sampled, and lipid content of the species under consideration, to name a few of the
 most important factors. Therefore, it is difficult to fully characterize the risks to wildlife and
 human health that are associated with the accumulation of COPCs in the food web.

 Sediment characteristics, such as TOC, can have a major influence on the bioavailability of
 nonpolar compounds and increase the among-site variation in bioaccumulation (ASTM
 2001d).  Calculation of BSAFs can reduce this variability. Biota-sediment accumulation
 factors  are  calculated  as  the  ratio  of lipid-normalized  tissue residue  to  organic
 carbon-normalized  sediment COPC  concentration  at  steady state,  with  units  of
 g-carbon/g-lipid.  Normalizing tissue  residues to tissue lipid concentrations reduces the
 variability in chemical  concentrations  among individuals of the same species  and between
 species.     These  normalization  procedures  can  be  used  to  develop  a  simple
 thermodynamic-based  bioaccumulation model for chemical uptake from sediment.  The
 fundamental assumptions of this thermodynamic model are that the tissue concentration is
 controlled by the physical partitioning of the compound between sediment carbon and tissue
 lipids and that the organism and the environment approach thermodynamic equilibrium. The
 method assumes that lipids in different organisms and TOC in different sediments partition
 chemicals in similar manners. The key input  parameter in the model is the BSAF, which
 predicts the lipid-normalized tissue residue  when multiplied by the TOC-normalized
 sediment chemical concentration.

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 In theory, BSAFs should not vary with sediment type or among species.  Based on the
 relationship between organic carbon partition coefficients (Koc) and lipid-normalized
 concentrations in tissue, the maximum BSAF for neutral organic compounds has been
 calculated to be about 1.7 (ASTM 2001d). Measured BSAFs would be lower than this
 maximum if metabolism of the compound by the organism is rapid or the organism fails to
 reach steady-state body burdens due to limited exposure durations or kinetic limitations to
 accumulation  (for example, steric hindrances to uptake and slow desorption from sediment
 particulates to  interstitial  water).   Measured  BSAFs  could  exceed  the calculated
 thermodynamic maximum if there is active uptake of the chemical  in the gut or if there is an
 increase in the gut fugacity of the chemical, driving the chemical from the gut into the body.
 The chemical fugacity in the gut could increase as the volume of food decreases during
 digestion or as a result of a reduction in lipids.

 The steps that should be used to assess tissue chemistry data are outlined in Figure 5.  Once
 tissue chemistry data have been assembled, the quality of the data needs to be determined
 using criteria  outlined in Section  5.4 of Volume III  and in ASTM (2001d) and USEPA
 (2000a). If the tissue chemistry data do not meet the quality needed for the assessment, it
 may be necessary to repeat certain components of the sampling program.

 The measured concentrations of COPCs in biological tissues should be compared to regional
 background levels to determine if tissues contain elevated levels of COPCs (Figure 5).
 ASTM (200Id) and USEPA (2000a) provide  a description of procedures for conducting
 statistical analyses of data from bioaccumulation assessments.   Comparison of tissue
 chemistry data  to  published  toxicity  thresholds provides a basis  for determining  if
 bioaccumulative substances are present in the tissues of aquatic organisms at levels that are
 likely to be toxic to sediment-dwelling organisms or fish (e.g., Jarvinen and Ankley 1999).
 In addition, these data may be compared to numerical TRGs to determine if COPCs have
 accumulated in the tissues of aquatic organisms to such an extent that adverse effects on
 piscivorus wildlife species are likely to occur (Figure 5). Such TRGs for the protection of
 piscivorus wildlife  have been  developed by the New York State Department of
 Environmental Conservation (Newell et al. 1987). TRGs have also been developed for the
 protection of human health (USEPA 1989).  The results of tissue residue chemistry should

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       also be considered in conjunction with measures of sediment chemistry, sediment toxicity,
       and community status of benthic invertebrates and fish at the assessment area (Chapter 7 of
       Volume III).
5.7   Recommendations

       The results of bioaccumulation assessments provide essential information for evaluating the
       uptake of bioaccumulative substances from contaminated sediments by sediment-dwelling
       and other aquatic organisms.  In turn, this information provides a basis for evaluating the
       potential effects of bioaccumulative substances on aquatic-dependent wildlife and human
       health. The following recommendations are offered to support the design and interpretation
       of bioaccumulation assessments:

          •   Bioaccumulation  assessments should be included as an integral element of
             freshwater sediment quality assessments that are conducted at sites that are
             known or suspected to contain bioaccumulative substances;

          •   The uptake of bioaccumulative substances from freshwater sediments should be
             evaluated using the results of 28-day bioaccumulation tests with the oligochaete,
             Lumbriculus  variegatus (i.e., to support the determination of BSAFs and the
             prediction of levels in higher tropic level organisms).  It is recommended that 28-
             day toxicity tests with the oligochaete Lumbriculus variegatus be conducted
             following procedures outlined in ASTM (200Id) and USEPA  (2000a) and in
             Tables 18 and 19;

             The concentrations of bioaccumulative COPCs in test organisms exposed to
             control  sediments should be determined  at the beginning and end  of the
             bioaccumulation test to support interpretation of the results of tests conducted
             using site sediments;
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        The  physical and chemical  characteristics of sediments  that  are  used in
        bioaccumulation tests should be determined, in accordance with the guidance
        provided in ASTM (200Id) and USEPA (2000a);

        The  concentrations  of bioaccumulative  COPCs should  be  determined in
        sediment-dwelling organisms that are obtained from field-collected sediments to
        validate the results of laboratory bioaccumulation tests and to  evaluate the
        potential for adverse effects on invertebrate-eating wildlife species (e.g., fish,
        sediment-probing birds);

        The  concentrations of bioaccumulative substances in the tissues  of aquatic
        organisms (fish  and shellfish) from the  site under  investigation  should be
        determined to evaluate the potential for adverse effects on aquatic-dependent
        wildlife and human health;

        A conceptual model of the site, including COPCs, potential exposure pathways,
        and receptors at risk, should be developed to guide the selection of species for
        bioaccumulation testing and tissue residue analysis;
        Following the selection of the most appropriate bioaccumulation test(s) for the
        specific application, the test procedures and DQOs should be described in the
        project QAPP;

        The procedures for interpreting the results of the bioaccumulation tests and the
        tissue residue data for field-collected samples should be described in the data
        analysis plan that is developed as part of the overall problem formulation process;

        The first step in the data interpretation process should involve evaluation of test
        and data acceptability (i.e., by comparing the results to the  DQOs that were
        established in the QAPP);

        The results of bioaccumulation tests should be compared to those obtained at the
        beginning  of the test and/or those obtained for control sediments to evaluate the
        uptake of bioaccumulative COPCs;
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    •   The results  of bioaccumulation tests  and the measured concentrations  of
        bioaccumulative COPCs in aquatic organisms may be compared to toxicity
        reference values (TRVs) and/or TRGs to evaluate the potential for effects on
        aquatic-dependent wildlife and/or human health; and,

    •   Applications of exposure models and dose-response relationships provides a
        basis for refining the effects assessments that are conducted using the tissue
        residue data in conjunction with TRVs and TRGs.


 The bioaccumulation  of sediment-associated contaminants can  best be  determined by
 conducting laboratory bioaccumulation tests with sediments collected from the area of
 interest. Minimum physical and chemical characterization of sediment samples used in these
 bioaccumulation tests are  outlined in Section 3.7 of Volume III dealing with sediment
 toxicity testing (see also ASTM 200Id and USEPA 2000a).  In addition to laboratory
 bioaccumulation testing, it is also useful to collect organisms inhabiting sediments at the area
 of interest to determine the potential for food chain transfer of contaminants to upper trophic
 levels.  It is critical to use analytical methods that have been previously demonstrated to meet
 the desired detection limits for tissue residues and lipids. It is also important to establish a
 minimum tissue mass per replicate needed for all of the required analyses before conducting
 an assessment  of bioaccumulation  with  either  field-collected  or laboratory-exposed
 organisms.
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                                            FISH HEALTH AND FISH COMMUNITY ASSESSMENTS - PAGE 78
Chapter 6.    Fish     Health     and     Fish  Community
                   Assessments
6.0  Introduction

      Contaminated sediments have been demonstrated to be toxic to sediment-dwelling organisms
      and fish (MacDonald and Ingersoll 2000). More specifically, exposure to contaminated
      sediments can result in decreased survival, reduced growth, or impaired reproduction in
      benthic invertebrates and/or fish.  Additionally, certain COPCs in the sediments are taken
      up by organisms through bioaccumulation (Chapter 5 of Volume III). As a result, benthic
      organisms, fish, birds, and mammals can be adversely affected by contaminated sediments.
      This chapter describes procedures for assessing potential impacts of contaminated sediment
      on fish health and on the composition offish communities.
6.1  Selecting Metrics and Targets in Fisheries Assessments

      Data on fish health provides important information for determining if fish have been
      adversely affected by exposure to contaminated sediments. Fish health represents a relevant
      indicator of sediment quality conditions because fish that are exposed to contaminated
      sediment can exhibit impaired health. Health can be defined as the capacity of an organism
      to withstand stress (Schmitt et al. 2000).  Hence, the more stressed (i.e., less healthy) an
      organism is, the less capacity it has to  withstand further stress (Bayne et al.  1985).
      Assessments offish health are intended to integrate the overall responses of an organism to
      environmental stresses, including exposure to toxic and bioaccumulative substances (Schmitt
      etal. 2000). Fish health represents a relevant indicator of sediment quality conditions as fish
      that are exposed to contaminated sediments can exhibit a variety of responses, some of which
      provide evidence of exposure to COPCs and others which indicate that such exposures are
      adversely affecting the organism.

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 Investigators in the fish health field have utilized a number of metrics to assess exposure to
 toxic and bioaccumulative substances. For example, tissue chemistry data have been used
 extensively to quantify exposures to bioaccumulative substances, such  as PCBs, PAHs,
 PCDDs/PCDFs, and OC pesticides (Table 21).  In addition, a number of metrics, such as
 ethoxyresorufin-O-deethylase (EROD) activity in liver (responsive to PCBs, PAHs, and
 PCDDs/PCDFs), H4IIE assay  results  in whole fish  (responsive to PCBs, PAHs,  and
 PCDDs/PCDFs), sex steroid (estradiol and testosterone) levels in plasma (responsive to
 endocrine modulating substances), metallothein levels in liver and kidneys  (response to
 metals), vitellogenin in plasma  (response to endocrine modulating compounds),  and
 macrophage aggregate analyses of spleen, kidney, and liver (responsive to PAHs and metals)
 have been used as evidence of exposure to various classes of contaminants (McCarthy and
 Shugart 1990; Schmitt et al.  2000; Table 21).  While these metrics provide information on
 exposures to toxic and bioaccumulative substances, they do not provide direct information
 on the effects that are associated with such exposures.  Therefore, more direct measures of
 the effects of exposures to COPCs on fish heath are also needed in assessments of sediment
 quality conditions.

 There are a number of metrics that can be used to provide information on the overall health
 of fish that have been exposed to elemental  and  organic chemicals.  For  example,
 histopathological examination offish liver, gills, gonads, spleen, and kidney has been used
 to determine the frequency of lesions and tumors in fish (Malins et al. 1985; Goyette et al.
 1988; Payne et al. 1988). Somatic indices, such as the relative mass of gonads, spleen, and
 liver, have also been used as a measure of overall organism health (Grady et al. 1992).
 Furthermore, necropsy-based fish health assessments, which include visual examination of
 all tissues for external and internal abnormalities (e.g., deformities, fin erosion, lesions,
 tumors, parasites), can also be used to evaluate organism health(Nenere^ al. 1995; Antcliffe
 et al. 1997;  Schmitt  et al.  2000). These types of information on fish  health status are
 important because impaired fish health can lead to increased rates offish mortality and result
 in associated effects on fish populations.

 Establishment of targets for fish health depends on the determination of normal conditions
 for the  fish  species that reside in the geographic area under consideration. In some areas

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 (e.g., Indiana, Ohio), the incidence of deformities, fin erosion, lesions and tumors (i.e., DELT
 abnormalities) in fish have been determined for uncontaminated reference sites (Sobiech et
 al. 1994).  As such, statistical  comparisons can be made of the  metric scores that are
 measured at the contaminated site and the reference areas.  In this way, it is possible to
 determine if fish health has been adversely affected at the site under investigation.

 Exposure to toxic and bioaccumulative chemicals can adversely affect fish in several ways.
 First, exposure to COPCs can cause behavioral abnormalities, increased incidence of disease,
 decreased fish health, impaired reproduction, and elevated levels of mortality. In addition,
 the presence of sediment-associated contaminants can impact the benthic invertebrate
 community and, thereby, reduce the abundance of preferred fish food organisms. As such,
 affected aquatic habitats may support only reduced populations offish.

 A variety of metrics can be used to assess the status of fish communities in freshwater
 ecosystems. Such metrics provide information on species composition (i.e., total number of
 species, types of species, percent sensitive species, and percent tolerant species), on trophic
 composition (i.e., percent omnivores, percent insectivores, and percent pioneer species), and
 on fish health (Karr and Chu 1997; 1999).  Other metrics that have been used in various
 investigations include, species richness,  total abundance, percent alien taxa, and trophic
 status (Karr and Chu 1999). Integration of these metrics into multimetric indices,  such as
 the Index of Biotic Integrity (IBI) and the Index of Weil-Being (IWB), provides a basis for
 evaluating the overall status of the fish community, rather than individual attributes of the
 community (Yoder and Rankin 1995; Karr and Chu 1999). In many areas, IBI and/or IWB
 scores have been determined for appropriately selected reference sites within the ecoregion
 under consideration (e.g., Indiana - Sobiech etal. 1994; Ohio - OEPA 1988a; 1988b; 1989;
 Florida - Griffith et al. 1994). In this way, the status of the fish community at a contaminated
 site can be compared with the community that would normally occur in areas with similar
 physical  habitats,  in the absence of chemical contamination.  MacDonald and Ingersoll
 (2000) and MacDonald etal. (2002b) applied this approach to identify areas with the Indiana
 Harbor area of concern that had  degraded fish communities.
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6.2   Availability of Standard Methods
       Standard methods for collecting and processing offish samples have not been established
       by organizations such as the ASTM.  Nevertheless, USEPA (2000d) has developed guidance
       on the collection and analysis offish tissues. However, guidance has recently been published
       for evaluating fish health as part of the USGS biomonitoring of environmental status and
       trends (BEST) program (Schmitt et al. 2000).  The BEST program has been designed to
       document temporal and  spatial trends in fish health through the use of chemical and
       biological monitoring methods.  Fish are normally selected for  sampling based on:

          •   A high potential for exposure and response to COPCs;

          •   Having a territory that overlaps the area being monitored; and,

          •   Being large and abundant enough to permit sampling.


       Methods are outlined in the BEST protocols for measuring  several metrics,  including
       histopathology, EROD activity, lysozyme activity, macrophage aggregate analysis, H4IIE
       bioassay, vitellogenin, sex steroids, chemical analyses of whole fish,  somatic indices, stable
       nitrogen isotopes, and necropsy-based fish health examination.  See Table 21 for a brief
       description of each of these metrics.  A general measure of overall organism health can be
       evaluated using metrics such as histopathology, lysozyme activity, or necropsy for internal
       or external abnormalities. Metrics such as H4IIE and EROD can be used to determine if fish
       have  been  exposed to  specific  classes  of  compounds,  such  as  PCBs,  PAHs,  or
       PCDDs/PCDFs.
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6.3   Advantages and Disadvantages
       Evaluation  of fish health offers a number of advantages relative to the assessment of
       sediment quality conditions. First, fish are often keystone species in aquatic ecosystems (i.e.,
       species that influence the structure and/or function of the ecosystem as a whole); therefore,
       data on fish health can provide relevant information for assessing the health of the ecosystem
       as a whole.  In addition, human uses of aquatic ecosystems are often dependent on the
       availability and quality of sport and food fish.  As impaired fish health can adversely affect
       such uses, fish health data can be used to assess the maintenance and restoration of the
       designated water uses. Importantly, certain COPCs that do not bioaccumulate to elevated
       levels in fish tissues can adversely affect their health (e.g., PAHs).  Therefore, fish health
       assessments can provide relevant data for evaluating the effects of such COPCs (Malins et
       al.  1985; Payne etal 1988).

       While fish health assessments can be highly relevant in evaluations of sediment quality
       conditions, there are several limitations that influence their applicability. First, assessments
       offish health typically involve destructive sampling of substantial numbers offish to support
       statistical comparisons between contaminated sites and reference areas, potentially impacting
       the populations of affected  species. In addition, fish health can be affected by exposure to
       water-borne chemicals  or habitat gradients, in addition to sediment-associated COPCs.
       Therefore, adverse effects cannot necessarily be attributed to contaminated sediments.
       Furthermore, fish can be migratory species that reside within the site under consideration for
       variable and unknown time periods.  Hence, it is difficult to fully determine the duration of
       exposure to contaminated sediments.

       Many of the advantages that were cited for fish health assessments are also relevant to fish
       community assessments. That is, as keystone species in aquatic ecosystems, information on
       fish community status can provide valuable information on the health of the ecosystem as
       a whole. Additionally, changes in the composition of the fish community or the abundance
       of  certain  fish species  have  the potential to adversely affect the designated uses of a
       waterbody.  Importantly, unlike fish health assessments, fish community assessments do not
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                                               FISH HEALTH AND FISH COMMUNITY ASSESSMENTS - PAGE 83
       necessarily require destructive sampling and, hence, can be conducted without significantly
       adversely affecting fish populations.

       In spite of the advantages noted above,  fish community assessments have a number of
       limitations that can influence their applicability in sediment quality investigations. First and
       foremost, fish communities can be affected by a variety of natural (e.g., flooding, drought)
       and anthropogenic (e.g., habitat alterations,  fishing pressure, water-borne contamination,
       sediment-associated contamination) stressors. Additionally, fish are often not always in
       direct contact with sediment; as such, it is challenging to determine the cause or causes of
       changes in the composition of the fish community. Furthermore, fish tend to be migratory
       species and, as such, the composition offish communities can change on seasonal bases in
       response to natural factors, such as food supply, temperature  changes, and reproductive
       status.  Finally, the applicability offish health and fish community data can be limited due
       to difficulties associated with obtaining sufficient samples to support statistical analysis of
       the data.
6.4   Evaluation of Data Quality
       Performance-based methods have been recommended for determining the acceptability of
       sediment chemistry (Chapter 2 of Volume III)  or sediment toxicity tests (Chapter 3 of
       Volume HI).  Unfortunately, performance-based methods have not been established to
       determine the acceptability of fish health data or fish community data.  The first step in
       conducting an evaluation of fish communities is the development of an appropriate
       experimental design. An inappropriate experimental design can be a major source of error
       in the resulting data. There are many factors to be considered when sampling fish that differ
       from the considerations required for sampling sediments (Chapter 2 of Volume III).  Fish
       communities can be influenced by abiotic factors in the absence of COPCs, and in some
       cases, the effects of COPCs can be masked by effects due to these abiotic factors (Sobiech
       etal. 1994). Important abiotic characteristics (i.e., water quality, current velocity and depth,
       shade cover) at the site need to be  evaluated so that potential confounding effects of these

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       characteristics can be accounted for when data is analyzed and interpreted. This holds true
       whether the intent of the project is to make comparisons between upstream and downstream
       areas, between different aquatic systems (different lakes or rivers), or between seasons.

       When assessing fish communities, it is critical to select appropriate reference sites. Ideally,
       reference sites should be unaffected or minimally affected by anthropogenic influences
       (ASTM 200la; Appendix 3 of Volume II). In addition to having low concentrations of
       COPCs in sediment, the  reference  sites  should  also  have  physical  and  chemical
       characteristics of both water and sediment that are similar to the study site to minimize the
       potential effects of these characteristics on fish communities. See Appendix 3 of Volume
       n for additional discussion of reference sites. The methods that are to be used in fish health
       and/or fish community assessments should be documented in the project QAPP.
6.5   Methodological Uncertainty

       A review of uncertainty associated with endpoints measured in fish health or fish community
       assessments of sediment quality was not addressed in Ingersoll et al. (1997). Nevertheless
       the  same criteria that were established  by Ingersoll et al. (1997) can be used in  this
       assessment to estimate uncertainty associated  with measures of fish health and  fish
       community structure in the assessment of sediment quality (Table 22) including: precision;
       ecological relevance; causality; sensitivity; interferences; standardization; discrimination;
       bioavailability; and, field validation.

       The primary purpose offish health or fish community metrics are to identify departure of the
       endpoint from either  an expected or predicted condition, given natural  variability in both
       time and space.  Furthermore, these metrics should relate such a departure to a directional
       stressor.  The precision of a fish community assessment was rated as moderate given
       movement offish within the area of interest and the lack of direct contact with sediment by
       many fish species. In contrast, fish health metrics were rated as relatively precise assuming
       that consistent methods are used to perform these evaluations. Ecological relevance in Table

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       22 refers to the relation of the measured endpoint to the fish community at the area of
       interest. Accordingly, direct measures of the fish health or fish communities have a high
       certainty of being related to ecosystem responses at the area of interest.  However, some of
       the fish health endpoints provide an indication only of exposure and not necessarily of an
       effect.

       Measurements offish community structure provide limited information on specific COPCs
       or stressors causing the response. The response offish may be to either COPCs in sediment
       or physical factors that interfere with interpretations of sediment quality, such as substrate,
       shade, flow, and water quality characteristics of the overlying water at the area of interest.
       In contrast, fish health metrics can be used to identify specific chemical stressors that may
       be causing adverse responses to organisms  (e.g., EROD  activity,  lysozyme activity,
       macrophage aggregate analysis, H4IIE bioassay, vitellogenin, sex steroids). Neither fish
       health nor fish community metrics have been standardized through such organizations as
       ASTM; however,  detailed methods have been described for  conducting these measures
       (OEPA 1988a; 1988b; 1989; Schmittefor/. 2000; USGS 2000).  Methodological uncertainty
       relative to discrimination and bioavailability were  both  rated  relatively high for fish
       community assessment given the difficulty in linking effects observed on fish to a specific
       location with contaminated sediments (Table 22). Because certain metrics used in fish health
       assessments respond to a specific class or classes of COPCs, the uncertainty associated with
       discrimination and bioavailability was considered to be lower. Both fish health and fish
       community metrics have been extensively field validated, but these assessments have not
       been routinely used to assess sediment quality.
6.6   Interpretation of Data
       The steps that should be used to assess fish health data are outlined in Figure 6.  Once fish
       health data have been assembled, the quality of the data needs to be determined using criteria
       outlined in Section 6.4 of Volume IE. If these data do not meet the quality needed for the
       assessment, it may be necessary to repeat certain components of the sampling program.

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       Establishment of targets for fish health depends on determining normal conditions for the
       fish species that reside in the geographic area under consideration. For example, background
       conditions in terms of the incidence of DELT abnormalities in fish have been determined for
       areas in Indiana and Ohio (Sobiech et al. 1994).  As such, fish health at test stations within
       these areas can be compared to the target for a geographic area being considered (Figure 6).
       If the incidence of adverse effects associated with fish health is not different from the
       geographic target, then fish health is unlikely to be adversely affected at the test station.
       However, if the incidence in abnormalities is higher than the geographic target, test stations
       are classified as having a degraded fish health.

       As is the case for fish health, establishment of targets for the fish community necessitate
       determination of normal conditions for uncontaminated sites within the same ecoregion as
       the site under investigation. In Ohio, for example, data collected throughout the state have
       been used to generate IBI and IWB scores that denote exceptional, good, fair, poor, and very
       poor fish  communities at  three types of sites, including wading sites, boat sites, and
       headwater sites (OEPA 1988a; 1988b; 1989).  Similarly, Indiana has calibrated the IBI for
       use in several ecoregions, thereby making it applicable for use in a number of areas within
       the state.  In the absence of such benchmarks, normal conditions may be determined by
       selecting and sampling one or more reference sites that have similar habitat characteristics,
       but are unaffected by chemical contamination.  The results offish health assessments should
       be considered in conjunction with measures  of fish  community  structure and results of
       companion assessments of sediment chemistry, sediment toxicity, and bioaccumulation that
       are conducted at the assessment area (see Chapter 7 of Volume III).
6.7   Recommendations

       Fish  health and  fish community assessments provide useful  ancillary  information for
       evaluating exposure to,  and the effects of,  sediment-associated COPCs  in freshwater
       ecosystems.   Based  on the forgoing  evaluation of fish  health  and fish  community
       assessments, the following recommendations are offered:

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                                          FISH HEALTH AND FISH COMMUNITY ASSESSMENTS - PAGES?
        Fish health assessments can be used to assess exposure offish to certain classes
        of COPCs,  including  metals,   PAHs,  PCBs,   OC  pesticides,  and/or
        PCDDs/PCDFs;

        The metrics that provide the most direct information on exposure offish to toxic
        and bioaccumulative COPCs include EROD, H4IIE,  vitellogenin, and  sex
        steroids;

        The metrics that provide the most direct information on the health of exposed fish
        include histopathology, lysozyme activity, somatic indices, and necropsy-based
        fish health assessments;

        The procedures that are to be used to assess fish health and fish community status
        should be documented in the QAPP;

        The procedures for interpreting the results of fish health and fish community
        assessments should be described in the data analysis plan that is developed as part
        of the overall problem formulation;

        The first step in the data interpretation process should involve evaluation of data
        acceptability (i.e., based on the DQOs that were established in the QAPP; and,

        The results obtained for test sites should be compared with the results obtained
        for appropriate reference sites [i.e., uncontaminated sites which have  similar
        physical (e.g., grain size, water depth) and chemical (e.g., dissolved oxygen)
        characteristics as the test sites].
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                                  INTEGRATION OF INFORMATION ON MULTIPLE INDICATORS OF SOCs - PAGE 88
Chapter 7.    Integration   of   Information   on  Multiple
                   Indicators of Sediment Quality Conditions
7.0  Introduction

      Sediment quality assessments are typically conducted to determine if sediments have become
      contaminated as a result of land or water use activities.  When such contamination is
      indicated,  the results of sediment quality assessments need to provide the information
      required to evaluate the nature, severity, and areal extent of sediment contamination. In turn,
      this  information can be used to identify actual and probable use impairments at the
      assessment area. The purpose of this chapter is to describe procedures for interpreting the
      data that are generated for assessing effects on sediment-dwelling organisms, on aquatic
      dependent wildlife, or on human health (Chapter 5 of Volume I). Procedures for evaluating
      the quality of the data generated for specific indicators, such as sediment chemistry or
      sediment toxicity, are outlined in Chapters 2 to 6 of Volume HI.  Procedures for determining
      if specific targets for each of these individual indicators have been exceeded are also
      described in these earlier chapters.  Importantly, approaches for integrating data that are
      generated from multiple lines of evidence, including sediment chemistry, sediment toxicity,
      bioaccumulation, or responses of organisms in the field, are  described in the following
      sections.  A series of contingency tables (Tables 23 to 24) are presented which can be used
      to interpret impacts on aquatic life, wildlife,  or human health using  a weight-of evidence
      approach.
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7.1   Integration  of  Information  on  Multiple  Indicators  of
       Sediment Quality Conditions

       While individual indicators of sediment quality each have an inherent level of uncertainty
       associated with their application, the uncertainty associated with an overall assessment of
       sediment contamination can be reduced by integrating information  from each of these
       individual indicators.  For example, sediment chemistry, sediment toxicity, and benthic
       community data can be used together in a sediment quality triad assessment to establish a
       weight-of-evidence linking contaminated sediments to adverse effects on sediment-dwelling
       organisms (Table 23). The integration of multiple tools using a weight-of-evidence approach
       has the potential to substantially reduce  uncertainty associated with  risk assessments of
       contaminated sediment and, thereby, improve management decisions (Long and Chapman
       1985;  Chapman 1992; Canfield et al. 1996; Ingersoll et al. 1997; Wenning and Ingersoll
       2002).

       The first step in the evaluation of sediment quality data should be to determine if individual
       indicators exceed the established targets.  For example, the following questions should be
       addressed:

          •   Do the concentrations of COPCs in sediments exceed applicable SQGs (Figure
             1)?

          •   Are sediments toxic relative to control and/or reference treatments (Figure 3)?

          •   Are  communities of invertebrates  or fish  in the field  degraded relative to
             reference conditions (Figure 4 or 6)?

          •   Do the concentrations of COPCs in tissues exceed TRGs (Figure 5)?

          •   Is the health offish compromised relative to reference conditions (Figure 6)?


       The answers to these questions will help to establish if metrics associated with each of these
       individual indicators are adversely affected at the test stations relative to  the reference

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                              INTEGRATION OF INFORMATION ON MULTIPLE INDICATORS OF SOCs - PAGE 90
 stations.  However, it is also important to determine the relationships among individual
 indicators measured at the assessment area.  These relationships can be  evaluated most
 directly by using scatter plots of the data to determine if there is correspondence between
 pairs of indicators and associated metrics measured on splits of individual samples collected
 from stations in the assessment area (e.g., sediment toxicity vs.  sediment chemistry).
 Alternatively, the scatter plots can be used to evaluate broader trends across geographic
 reaches within the assessment area (e.g., fish community status or fish health vs. sediment
 chemistry). Comparisons offish community status or tissue chemistry offish are often made
 across multiple stations sampled for sediment chemistry to account for the movements offish
 within the assessment area.

 Statistical regression analyses can be used to determine if there are significant relationships
 between pairs of indicators and associated metrics.  For example, Figure  7 illustrates the
 relationship between sediment chemistry (as a function of mean PEC-Qs) and sediment
 toxicity (as a function of toxicity to Hyalella azteca in 10-day sediment tests).  Similarly,
 relationships between metrics for a particular indicator can also be evaluated using scatter
 plots. Figure 8 illustrates the relationship between two metrics for sediment chemistry: SEM
 normalized to AVS (i.e., SEM-AVS) and toxic units of metals measured in pore water from
 these same samples.  The  results  of these types of analyses can be used to establish
 concordance among various indicators (i.e., high chemistry and toxic, low chemistry and not
 toxic).  Additionally, these analyses can help to establish the rate of false positives (i.e., high
 chemistry and not toxic) or false negatives (i.e., low chemistry and toxic) among various
 indicators.

 The following sections describe procedures for  using contingency tables in an  expanded
 version of the sediment quality triad approach to incorporates measures of bioaccumulation
 with the traditional  measures  of  sediment  quality (MacDonald  1998).  Specifically,
 integration of data from sediment chemistry, sediment toxicity, community status, and/or
 tissue chemistry provides important information  for assessing sediment quality conditions.
 The contingency tables presented in Tables 23 to 24 provide a means of interpreting the data
 generated from multiple indicators of sediment quality using a weight-of-evidence approach.
 The results of these analyses can be used to estimate the likelihood of impacts of sediment

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 contamination on aquatic life  (sediment-dwelling organisms), wildlife  (vertebrates), or
 human health.
 7.1.1    Integration of Information on Multiple Indicators for
           Assessing Impacts on Sediment-Dwelling Organisms and
           Other Receptors

 Historically, the sediment quality triad is the approach that has been used most frequently to
 evaluate the concordance between measures of sediment chemistry, sediment toxicity, and
 benthic  community  structure in the assessment of impacts of on  sediment-dwelling
 organisms.  The continency table presented in Table 23 presents eight possible outcomes
 based on the correspondence among these three indicators of sediment quality. Alternatively,
 broader assessments of sediment quality conditions can be conducted by also considering the
 potential for bioaccumulation.  There are 16 possible outcomes when four individual
 indicators of sediment quality are evaluated (sediment chemistry, sediment toxicity, benthic
 community surveys and tissue chemistry; Table 24) providing a basis for assessing effects
 on sediment-dwelling organisms, aquatic-dependent wildlife,  and/or  human health.
 Frequently, there may only be two indicators of sediment quality reported for a particular site
 assessment (i.e., chemistry and toxicity), which would result in a contingency table with four
 possible outcomes (Table 25).

 In each of these contingency tables, a "+" or "-" within in a column and row designates that
 the indicator for a particular sample (or station) is classified as being adversely affected "+"
 or not"-" relative to the established target.  Multiple metrics can be used in classifying an
 individual indicator as impacted or not impacted.  For example, multiple sediment toxicity
 tests  or multiple measures of sediment chemistry may be reported for splits of the same
 sample collected from a station.  MacDonald and Ingersoll (2000) and MacDonald et al.
 (2002a; 2002b) classified a sample as toxic if one or more of the tests on a sample exceeded
 the target for toxicity relative to control or  reference sediments.  Similarly, a sample was
 designated as impacted if one or more measures of sediment chemistry exceeded established

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 targets for selected SQGs. Alternatively, Canfield etal. (1994; 1996) described a procedure
 for ranking multiple metrics for a particular indicator to designate a sample (or station) as
 impacted.  Menzie et al. (1996) and MacDonald et al.  (2002c) describe procedures for
 assigning weighting factors when ranking multiple metrics in an ecological risk assessment.
 Carr et al. (2000) described a procedure for using principal component analyses to classify
 indicators of sediment quality as impacted relative to reference conditions.

 Concordance among the various indicators of sediment quality measured on the same sample
 generates a high level of confidence that the sample is being correctly classified as impacted
 or not impacted.  For example, if each of the four indicators of sediment quality were
 designated as adversely affected (line 1 in Table 24), it would be highly likely that the station
 is impacted due to contaminant-induced degradation in the field resulting in direct toxicity
 and bioaccumulation. Similarly, if all of the indicators except for bioaccumulati on indicated
 that a station is impacted (line 9 in Table 24), it is highly likely that the station is being
 adversely affected by the toxic substances present in contaminated sediments.  In this case,
 however, bioaccumulative substances are probably not  contributing to use impairment.
 Alternatively, if each of these four indicators of sediment quality were designated as not
 adversely affected (line 10 in Table 24), it would be highly unlikely that the station is being
 impacted. There may be stations where the individual indicators are not in concordance. For
 example, there may be no indication of effects based on sediment chemistry, toxicity, or
 benthic community structure,  but bioaccumulation is occurring, based on exceedances of
 tissue chemistry targets (line 2 in Table 24). In this instance, it is unlikely that COPCs would
 be directly toxic to organisms at the station. However, adverse effects on aquatic-dependent
 wildlife and/or human health could be occurring.

 There may be instances where sediment toxicity, benthic community structure,  or tissue
 chemistry identify a station as impacted, but sediment chemistry is not elevated (i.e., lines
 4, 7, or 15 in Table 24). In these instances, the  station may be impacted as a  result of
 unmeasured substances contributing to the toxicity. In other instances, there may be impacts
 identified with sediment chemistry and toxicity, but community structure is not impacted
 (i.e., lines 6 or 14 in Table 24).  This situation may be the result of spatial variability of
 COPCs in the field that is not identified with composited samples used to measure chemistry

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 and toxicity. Impacts on benthos in the field without corresponding impacts identified with
 sediment chemistry or toxicity may also result from spatial  (or temporal) variability of
 contaminants in the field (i.e., lines 5 and 13 in Table 24). However, effects on organisms
 in the field also may reflect differences in habitat or other physical factors (i.e., low dissolved
 oxygen) rather than reflecting responses to COPCs (line  13 in Table 24). The presence of
 elevated levels of bioaccumulative COPCs in tissues indicates the potential for adverse
 effects on aquatic-dependent wildlife and/or human health.

 Sediment may not be toxic in laboratory tests, but there may be elevated levels of COPCs,
 bioaccumulation, or evidence of altered benthic community structure (lines 3, 8, and 16 in
 Table 24). In these instances, the toxicity tests may not be sensitive enough to detect toxicity
 in the laboratory or chemicals in the sediment may not be directly toxic to organisms in the
 field.  Sediment may also have elevated  levels of COPCs without any other indication of
 sediment impacts (line 11 in Table 24).  In these instances, there may be COPCs that are not
 bioavailable in the sediments. Alternatively, the target SQGs may be too low. For example,
 if the targets for sediment chemistry were based on exceedances of threshold-type SQGs [i.e.,
 effects range-lows (ERLs) or threshold effect levels (TELs)], then there may be a high rate
 of false positives (SQG exceeded and non-toxic sample). Finally, there may be instances
 where sediments are identified as toxic in laboratory tests without any other indication of
 sediment contamination (line 12 in Table 24). In these instances, there may be unmeasured
 chemicals contributing to the toxicity.  Alternatively, the sediment toxicity test may be
 responding to an abiotic characteristic of the sediments that is  out of the tolerance range of
 the test organism (i.e., TOC influencing the growth of midges; ASTM 2001a).

 The simplest contingency table, where only two indicators of sediment quality have been
 measured at the sampling stations, is presented in Table 25.  In this example, sediment
 chemistry and  sediment toxicity are being compared and there  are only four possible
 outcomes.  A station could be identified as impacted or not impacted due  to toxicity and
 chemistry exceeding the established targets (lines 1 and 2 in Table 25). Elevated chemistry
 with no toxicity may be classified as a false positive (line 3 in Table 25). In this instance,
 the target thresholds for sediment chemistry may be set too low. Alternatively, the toxicity
 test may not have been sensitive enough to detect the elevated chemicals in the sample. A

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                              INTEGRATION OF INFORMATION ON MULTIPLE INDICATORS OF SOCs - PAGE 94
 sample identified as toxic without elevated chemistry would be classified as a false negative
 (line 4 in Table 25). Perhaps the toxicity test was responding to abiotic characteristics of the
 sediment (i.e., TOC  or ammonia).  Alternatively, there may be unmeasured chemicals
 contributing to the toxicity.  Clearly, the use of only two indicators can limit the overall
 interpretation sediment quality at a the  assessment  area.  Ideally, sediment chemistry,
 sediment toxicity, benthic community structure, and tissue chemistry, would be measured at
 all stations to provide a more robust evaluation of sediment quality (Table 24).

 Contingency tables are useful  for determining concordance among various indicators of
 sediment quality. Canfield et al. (1998) used a the contingency table similar to Table 23 to
 determine the percentage of stations in an assessment area classified in each of the eight
 possible outcomes.   A second approach for evaluating concordance  among individual
 indicators  of sediment quality would be to plot the data on a map (Figure 9).  Data for
 individual indicators in these  tri-axial  graphs  were arithmetically scored proportionally
 between 1  and 100 (i.e., 1 is indicative of the lowest concentration, least toxic, or most robust
 benthic community observed and 100 is the most impacted; Canfield et al. 1994). More than
 one metric can be used for a particular indicator by scoring each individual variable,
 summing these scores across the individual metrics, and re-scoring the sum of the combined
 scores between 1 and 100. The  results of these analyses can then be plotted on tri-axial
 graphs when three indicators are being evaluated (Figure 9). Alternatively, these plots could
 include multiple axes if additional indicators are being evaluated (i.e., quad-axial graphs for
 the contingency table presented in Table 24). These plots are useful for evaluating general
 trends among stations at the assessment area.  However, symmetry among the individual
 indicators  in these plots does not always represent concordance among the indicators. There
 may be instances where a relatively low score for sediment chemistry or toxicity is identified
 as impacted relative to the target, whereas a higher score for benthic community would be
 needed to identify a station as impacted relative to the corresponding target (Canfield et al.
 1996).

 Carr et al.  (2000) presented an alternative procedure for plotting the results of a sediment
 quality triad investigation  on a map of the study area.  Color-coded pie  diagrams for each
 station were subdivided into three sections and each section was used to classify chemistry,

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                              INTEGRATION OF INFORMATION ON MULTIPLE INDICATORS OF SOCs - PAGE 95
 toxicity, or benthic community as indicating high (green), medium (yellow), or low (red)
 sediment quality. A similar approach was used by MacDonald et al. (2002c) to assess risks
 to aquatic receptors associated with exposure to COPCs.

 An example application of the sediment quality triad assessment of sediment quality was
 presented in a series of papers by Canfield et al. (1994; 1996;  1998).  Sediment toxicity,
 chemistry, and  benthic community structure  were measured  at  stations located in the
 following areas:

    •   Three Great Lakes AOCs (Buffalo River, NY; Indiana Harbor, IN; Saginaw
        River, MI);

        The upper Mississippi River; and,

    •   The Clark Fork River located in Montana.


 The results of the benthic invertebrate community assessments were compared to the
 sediment chemistry and toxicity data for each site. Good concordance was evident between
 measures of laboratory toxicity (28-day sediment exposures with Hyalella azteca, which
 measured effects on survival, growth, and sexual maturation), sediment contamination, and
 benthic invertebrate community composition in highly contaminated samples. However, in
 moderately contaminated samples, less concordance was observed between the composition
 of the benthic community and either laboratory toxicity test results or sediment contaminant
 concentrations.  Laboratory sediment toxicity  tests which measured sub-lethal endpoints
 better identified chemical contamination in sediments compared to many of the commonly
 used measures of benthic invertebrate community composition.  One explanation for this is
 that the benthic  community attributes may reflect other factors,  such as habitat alterations,
 in addition to responding to COPCs. Canfield et al. (1994; 1996; 1998) concluded that there
 is a need to better evaluate non-contaminant factors (i.e., TOC,  grain size, water depth,
 habitat alteration) in order to better interpret the response of benthic invertebrates to sediment
 contamination.
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 Geographic information systems (GIS) provide another alternative for interpreting sediment
 quality data.  Using this approach, the matching sediment chemistry, sediment toxicity, and
 benthic invertebrate structure data are georeferenced in a relational database.  Subsequent
 overlay mapping of the information on the three or more types of indicators facilitates
 identification of the areas that have various degrees  of concordance among the indicators.
 In this way, it is possible to rank the relative priority of the various reaches in the study area.
 For example, the reaches in which the majority of sediment  samples exhibit  elevated
 chemistry, significant toxicity, and degraded benthos  would be considered the highest
 priority for developing and implementing sediment restoration options.  In contrast, those
 reaches in which a high proportion of samples are relatively uncontaminated, non-toxic, and
 have normal benthos  would be the highest  priority  for ongoing protection.   Other
 management actions (e.g., further investigation) may be needed in the reaches with one or
 two indicators showing that the sediments have been degraded.   This type of ranking
 approach can also be applied to non-matching data that have been collected over a number
 of years.
 7.1.2    Integration  of Information on  Multiple Indicators of
           Sediment  Quality  in  the  Assessment  of  Impacts  on
           Wildlife

 In addition to effects on sediment-dwelling organisms, contaminated sediments have the
 potential to adversely affect a variety of aquatic-dependent wildlife (i.e., vertebrate) species,
 including fish, amphibians, reptiles, birds, and mammals. MacDonald and Ingersoll (2000)
 and MacDonald et al. (2002b)evaluated a total of five indicators for determining the potential
 effects of contaminated sediments on wildlife, including sediment toxicity to fish, fish health,
 fish community status, sediment chemistry, and tissue chemistry. For most assessments of
 the effects of contaminated sediments on wildlife species, measures of sediment chemistry,
 fish community status, and tissue chemistry are the primary indicators evaluated, as sediment
 toxicity tests with fish and fish health assessments are not routinely reported in assessments
 of sediment quality conditions.  Effects on other wildlife species, such as amphibians,

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 reptiles, birds, and mammals, can be evaluated relative to either sediment chemistry (i.e., by
 applying bioaccumulation-based SQGs) or fish tissue chemistry (i.e., by applying TRGs for
 consumption by piscivorus wildlife).  The biggest challenge relative to the evaluation of
 effects of contaminated sediments on fish populations is the mobility of fish within the
 assessment area.   As  such,  it is difficult to  directly link elevated concentrations of
 contaminants in sediment to effects on fish.  Nevertheless, general patterns of sediment
 contamination within a groups of stations and fish populations samples from the same
 geographic area can be used to link contaminated sediments to adverse affects on  fish
 (Chapter 6 of Volume III).

 The continency table presented in Table 26 presents the eight  possible  outcomes for
 interpreting the correspondence among measures of sediment chemistry, fish community
 status, and tissue chemistry relative to the potential for impacts of contaminated sediment on
 wildlife. Note that if laboratory toxicity tests with fish were conducted with sediments from
 a station, a contingency table similar to  Table 23  could be used to evaluate relationships
 between sediment toxicity, sediment chemistry, and fish community status. Similarly, if fish
 health was evaluated, a contingency table similar to Table 26 could be used (i.e., substitution
 offish community status with fish health).

 If each of the three indicators listed in Table 26 are positive (i.e.,  bioaccumulation-based
 SQGs are  exceeded, fish community status is  impaired, and TRGs are exceeded; line  1 in
 Table 26), it is likely that wildlife are being impacted as a result of sediment contamination
 in the portion of the assessment area being evaluated.  Alternatively, if all  three of these
 indicators are not positive (line 2 in Table 26), it is unlikely that wildlife in the assessment
 area have not been  impacted (assuming that  these three  indicators are  representative
 surrogates for all wildlife inhabiting the portion of the assessment area being evaluated).
 Again, these comparisons offish community status (or fish health) and tissue chemistry are
 often made across multiple stations sampled for sediment chemistry, to account for the fact
 that fish migrate among stations. Impacts may be identified on fish community status and/or
 tissue chemistry without an indication of elevated  sediment chemistry (lines 4, 5, and  7 in
 Table 26).  In these instances, effects on wildlife are probably not due to  sediment
 contamination within the stations being evaluated  (tissue residues maybe due to exposure

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                             INTEGRATION OF INFORMATION ON MULTIPLE INDICATORS OF SOCs - PAGE 98
 from other sites or other media types). Alternatively, there may be elevated chemistry
 without noticeable impacts on fish community status or tissue chemistry (line 3 in Table 26).
 In this instance, it may be that fish are not in direct contact with the sediments or the
 sediment-dwelling organisms from the stations being sampled.  Finally, impacts may be
 identified with sediment chemistry and either fish community status or tissue chemistry (lines
 6 and 8 in Table 26). In these instances, impacts on sediment quality on wildlife are likely
 resulting either through direct toxic effects (line  6) or through exceedances of TRGs for
 piscivorus wildlife (line 8).
 7.1.3    Integration of Information  on Multiple Indicators of
           Sediment  Quality in  the  Assessment  of Impacts  on
           Human Health

 Humans may be exposed to sediment-associated contaminants via several routes of exposure
 including direct  contact with sediment (i.e., wading), through ingestion of surface water
 contaminated by sediments, or through consumption of shellfish, fish, and/or other wildlife
 species exposed to contaminated  sediments (Chapter 6 of Volume  III).  Crane (1996)
 described procedures for evaluating potential human health effects associated with direct
 contact with contaminated sediment, through ingestion of water contaminated by sediment,
 and through the consumption of contaminated fish.  The contingency table in Table 27
 addresses the  assessment of potential dietary impacts on human health associated with
 contaminated sediments, as  evaluated based on exceedances of sediment chemistry targets
 (bioaccumulation-based SQGs for human health) or exceedances of tissue chemistry targets
 (TRGs or fish consumption  advisories for human health).

 In instances where sediment chemistry and tissue chemistry are elevated in the assessment
 area (line 1 in Table 27), it is likely that sediment contamination has the potential to impact
 human health. Additionally, when sediment chemistry is elevated in the assessment area
 above bioaccumulation-based SQGs for humans but tissue chemistry targets are not exceeded
 (line 3 in Table 27), it is possible that there are impacts on human health.  In this instance,

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                                    INTEGRATION OF INFORMATION ON MULTIPLE INDICATORS OF SOCs - PAGE 99
       there may be wildlife in the assessment area exposed to the contaminated sediment that were
       not sampled for tissue chemistry.  Tissue chemistry may be elevated without substantial
       elevation in sediment chemistry (line 4 in Table 27).  In this instance, impacts on human
       health are possible, but organisms may not be exposed to sediments from the sampling
       stations.
7.2   Summary
       Contaminated sediments have the potential to adversely affect sediment -dwelling organisms,
       wildlife, and/or human health. Whenever practical, multiple lines of evidence (i.e., data on
       multiple indicators of sediment quality conditions) should be used to assess the quality of
       freshwater sediments. Procedures for determining if individual lines of evidence indicate
       that the beneficial uses of freshwater sediments are being impaired are described in Chapters
       2 to 6 of Volume in. The contingency tables presented in this chapter provide a basis for
       integrating the information on multiple indicators of sediment quality conditions and, in so
       doing, supporting informed decisions regarding the management of contaminated sediments.

       Importantly, the weight-of-evidence generated should be proportional to the weight of the
       decision in the management of contaminated sediments. At small and uncomplicated sites,
       the costs associated with detailed site investigations are likely to exceed the costs associated
       with the removal and disposal of contaminated sediments. In these cases, SQGs represent
       cost-effective tools for establishing clean-up targets and developing remedial action plans
       (Wenning and Ingersoll 2002).  At larger, more complicated sites, it is prudent to conduct
       further investigations when preliminary screening indicate that contaminated sediments are
       present.  In such cases,  the application of toxicity testing,  benthic  macroinvertebrate
       community assessments, and other tools provide a means of confirming the severity and
       extent of degraded sediment quality conditions (Wenning and Ingersoll 2002). Application
       of TIE procedures and/or sediment spiking studies provides a basis of confirming the identity
       of the substances that are causing or substantially-contributing to sediment toxicity (Ingersoll
       etal. 1997).

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                                                                     REFERENCES - PAGE 100
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Tables

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Table 1.  Sediment quality guidelines that reflect threshold effect concentrations (TECs; i.e., below which harmful effects are
         unlikely to be observed; from MacDonald et al.  2000b).
Threshold Effect Concentrations
Substance
Metals (in mg/kg DW)
Arsenic
Cadmium
Chromium
Copper
Lead
Mercury
Nickel
Zinc
TEL

5.9
0.596
37.3
35.7
35
0.174
18
123
Poly cyclic Aromatic Hydrocarbons (PAHs; in
Anthracene
Fluorene
Naphthalene
Phenanthrene
Benz [a] anthracene
Benzo(a)pyrene
Chrysene
Dibenz [a,h] anthracene
Fluoranthene
Pyrene
Total PAHs
NG
NG
NG
41.9
31.7
31.9
57.1
NG
111
53
NG
LEL

6
0.6
26
16
31
0.2
16
120
fig/kg DW)
220
190
NG
560
320
370
340
60
750
490
4000
MET

7
0.9
55
28
42
0.2
35
150

NG
NG
400
400
400
500
600
NG
600
700
NG
ERL

33
5
80
70
35
0.15
30
120

85
35
340
225
230
400
400
60
600
350
4000
TEL-HA28

11
0.58
36
28
37
NG
20
98

10
10
15
19
16
32
27
10
31
44
260
SQAL Consensus-Based TEC

NG
NG
NG
NG
NG
NG
NG
NG

NG
540
470
1800
NG
NG
NG
NG
6200
NG
NG

9.79
0.99
43.4
31.6
35.8
0.18
22.7
121

57.2
77.4
176
204
108
150
166
33.0
423
195
1610
                                                                                                                        Page 122

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Table 1. Sediment quality guidelines that reflect threshold effect concentrations (TECs; i.e., below which harmful effects are
           unlikely to be observed; from MacDonald et al.  2000b).
Threshold Effect Concentrations
Substance
TEL
LEL
MET
ERL
TEL-HA28
SQAL Consensus-Based TEC
Polychlorinated Biphenyls (PCBs; in [ig/kg DW)
Total PCBs
Organochlorine Pesticides (in
Chlordane
Dieldrin
Sum ODD
Sum DDE
Sum DDT
Total DDTs
Endrin
Heptachlor epoxide
Lindane (gamma-BHC)
34.1
fig/kg DW)
4.5
2.85
3.54
1.42
NG
7
2.67
0.6
0.94
70

7
2
8
5
8
7
3
5
3
200

7
2
10
7
9
NG
8
5
3
50

0.5
0.02
2
2
1
3
0.02
NG
NG
32

NG
NG
NG
NG
NG
NG
NG
NG
NG
NG

NG
110
NG
NG
NG
NG
42
NG
3.7
59.8

3.24
1.90
4.88
3.16
4.16
5.28
2.22
2.47
2.37
TEC = Threshold effect concentration (from MacDonald et al. 2000a).
TEL = Threshold effect level; dry weight (Smith et al. 1996).
LEL = Lowest effect level, dry weight (Persaud et al. 1993).
MET = Minimal effect threshold; dry weight (EC & MENVIQ 1992).
ERL = Effects range low; dry weight (Long and Morgan 1991).
TEL-HA28 = Threshold effect level forHyalella azteca; 28 day test; dry weight (USEPA 1996).
SQAL = Sediment quality advisory levels; dry weight at 1% OC (USEPA 1997).
NG = No guideline;  DW = dry weight.
                                                                                                                                              Page 123

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Table 2. Sediment quality guidelines that reflect probable effect concentrations (PECs; i.e., above which harmful effects are
         likely to be observed; from MacDonald et al.  2000b).
Probable Effect Concentrations
Substance
Metals (in mg/kg DW)
Arsenic
Cadmium
Chromium
Copper
Lead
Mercury
Nickel
Zinc
PEL

17
3.53
90
197
91.3
0.486
36
315
SEL

33
10
110
110
250
2
75
820
TET

17
3
100
86
170
1
61
540
ERM

85
9
145
390
110
1.3
50
270
PEL-HA28 Consensus-Based PEC

48
3.2
120
100
82
NG
33
540

33.0
4.98
111
149
128
1.06
48.6
459
Poly cyclic Aromatic Hydrocarbons (PAHs; in [ig/kg DW)
Anthracene
Fluorene
Naphthalene
Phenanthrene
Benz [a] anthracene
Benzo(a)pyrene
Chrysene
Fluoranthene
Pyrene
Total PAHs
Polych lorin ated Biph enyls
Total PCBs
NG
NG
NG
515
385
782
862
2355
875
NG
(PCBs; in fig/kg DW)
277
3700
1600
NG
9500
14800
14400
4600
10200
8500
100000

5300
NG
NG
600
800
500
700
800
2000
1000
NG

1000
960
640
2100
1380
1600
2500
2800
3600
2200
35000

400
170
150
140
410
280
320
410
320
490
3400

240
845
536
561
1170
1050
1450
1290
2230
1520
22800

676
                                                                                                                      Page 124

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Table 2. Sediment quality guidelines that reflect probable effect concentrations (PECs; i.e., above which harmful effects are
           likely to be observed; from MacDonald et al. 2000b).
Probable Effect Concentrations
Substance
PEL
SEL
TET
ERM
PEL-HA28 Consensus-Based PEC
Organochlorine Pesticides (in [ig/kg DW)
Chlordane
Dieldrin
Sum ODD
Sum DDE
Sum DDT
Total DDTs
Endrin
Heptachlor Epoxide
Lindane (gamma-BHC)
8.9
6.67
8.51
6.75
NG
4450
62.4
2.74
1.38
60
910
60
190
710
120
1300
50
10
30
300
60
50
50
NG
500
30
9
6
8
20
15
7
350
45
NG
NG
NG
NG
NG
NG
NG
NG
NG
NG
NG
17.6
61.8
28.0
31.3
62.9
572
207
16.0
4.99
PECs = probable effect concentrations (from MacDonald et al. 2000a)
PEL = Probable effect level; dry weight (Smith et al.  1996).
SEL = Severe effect level, dry weight (Persaud et al.  1993).
TET = Toxic effect threshold; dry weight (EC & MENVIQ 1992).
ERM = Effects range median; dry weight (Long and Morgan 1991).
PEL-HA28 = Probable effect level forHyalella azteca; 28-day test; dry weight (USEPA 1996a).
NG = No guideline; DW = dry weight.
                                                                                                                                             Page 125

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Table 3. Advantages and disadvantages of whole sediment and pore water chemistry (Ingersoll et al 1997).
Advantages
Disadvantages
* Provides direct information for determining the presence/absence
  ofCOPCs.

* Standard methods are available for most COPCs.

* Procedures are available for evaluating the reliability of the data
  (i.e., accuracy and precision).

* Methods for assessing the bioavailability of COPCs are available.

* Benchmarks (i.e., SQGs) are available for many COPCs for
  evaluating the potential for biological effects.
* Can not be used to evaluate effects on ecological receptors directly.

* Effective interpretation of the data is dependent on selecting the
  appropriate suite of analytes.

* The use of inappropriate methods (e.g., with high detection limits)
  can limit the utility of the resultant data.

* For pore water, it is challenging to obtain sufficient sample volumes
  to support the desired chemical analysis.

* Pore water extraction methods can alter pore water chemistry.
                                                                                                                                     Page 126

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Table 4. Uncertainty associated with sediment chemistry measurements (Ingersoll et al. 1997).

Precision
Ecological relevance
Causality: Contaminant
Causality: Source
Sensitivity
Interference
Standardization
Discrimination
Bioavailability
Field validation3
Bulk Sediment
1
3
1
2*
1*
2*
1*
1
2*
1
Total Organic
Carbon
Normalization
1
2
1
2
1*
2*
1*
1
1
2
SEM
minus AVS
1
2
1
2
1*
2*
1*
1
1*
2*
Metal
Speciation
(non AVS)
2*
2
1
2
1*
2*
3*
2*
2*
2*
Pore water
2*
2
2
2
1*
2*
2*
1
2*
3
Elutriate
1
3
3
3
1*
2*
2*
1
3
3
Reference
Element
1
3
1
1
1*
2*
1*
1
2
1
Ranking Code: 1 = low uncertainty (good); 3 = high (bad); * = lack of knowledge.
3 Not related to field sampling.
                                                                                                                                  Page 127

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Table 5. Uncertainty associated with sediment quality guidelines (Ingersoll et al  1997).

Precision
Ecological relevance
Causality
Sensitivity
Interference
Standardization
Discrimination6
Bioavailability
Field validation
ESBs1
1
2*
1
2
2
1
1
1
2*
ERL and ERM AET
2*
1
3*a
lc/2
2*
1
1
2*e
2*
3
2
3
3
2
2
3
2*e
2*
SLC SEM-AVS
3
3
3
1
3
2
3
1
3*
2*
1
1
2*
2*
1
2
1
2*
Toxic Unit
Models
3*
1
1*
2
2
3
2
2*
2
Residue-Based
SQG
2
2*b
2
1
1
1
1
1*
2*
Ranking Code: 1 = low uncertainty (good); 3 = high (bad); * = lack of knowledge.
3 with TU; b few compounds, based on consumption effects; ° ERL; d interferences resulting from community responses and mixture effects;e with normalization.
 ESB = Equilibrium Partitioning-derived Sediment Benchmarks (formerly known as Sediment Quality Criteria in Ingersoll et al.  1997).
                                                                                                                                           Page 128

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Table 6.  Summary of potential targets for pore-water chemistry.
Analyte
Metals
Aluminum
Arsenic
Cadmium
Chromium
Chromium (III)
Chromium (VI)
Copper
Lead
Mercury
Nickel

Silver
Zinc
WQ Criteria
Acute Chronic


340 (ig/L 150 (ig/L
4.3 (ig/L 2.2 (ig/L

570 (ig/L 74 (ig/L
16 (ig/L 11 (ig/L
13 ng/L 9 ng/L
65 (ig/L 2.5 (ig/L
1.4jig/L 0.77 ng/L
470 (ig/L 52 (ig/L

3.4 (ig/L
120 ng/L 120 ng/L
LC50for ^ r Invertebrates
ivctei ence ivetei ence Keterence
Hyalella azteca Acute Chronic


USEPA 1999
USEPA 1999 2.94 ng/L USEPA 1994 3.6 6 0.17 6 Outridgee^a/. 1994
15 2 2.5 2 CCREM 1987
USEPA 1999
USEPA 1999
USEPA 1999 35 ng/L USEPA 1994 20 ! 81 Spear and Pierce 1979
USEPA 1999 < 16 ng/L USEPA 1994 124 7 1 7 USGS 1998
USEPA 1999
USEPA 1999 780(ig/L USEPA 1994 102 5 15 2 EC and HC 1994;
CCREM 1987
USEPA 1999
USEPA 1999 73 ng/L USEPA 1994 51 7 10 7 USGS 1998
Polycyclic Aromatic Hydrocarbons (PAHs)
Acenaphthene
Acenaphthylene
Anthracene
Fluorene
2-Methylnaphthalene
Naphthalene
Phenanthrene
Benz(a)anthracene
















                                                                                                                        Page 129

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Table 6. Summary of potential targets for pore-water chemistry.
Analyte
                              WQ Criteria
                            Acute
Chronic
            Reference
   LC50for
Hyalella azteca
Reference
 Invertebrates
Acute   Chronic
Reference
PAHs (cont.)
  Dibenz(a,h)anthracene
  Benzo(a)pyrene
  Chrysene
  Fluoranthene
  Pyrene
  Total PAHs
Poly 'chlorinated Biphenyls (PCBs)
Aroclor 1016
Aroclor 1221
Aroclor 1232
Aroclor 1242
Aroclor 1248
Aroclor 1254
Aroclor 1260
Total PCBs
Pesticides
Chlordane
Dieldrin
sum ODD
sum DDE
sum DDT
Total DDT
Endrin
Heptachlor
0.014 ng/L USEPA 1999
0.014 ng/L USEPA 1999
0.014 ng/L USEPA 1999
0.014 ng/L USEPA 1999
0.014 ng/L USEPA 1999
0.014 ng/L USEPA 1999
0.014 ng/L USEPA 1999
0.014 ng/L USEPA 1999

2.4 (ig/L 0.0043 (ig/L USEPA 1999
0.24 ng/L 0.056 ng/L USEPA 1999


l.ljig/L 0.001 ng/L USEPA 1999
l.ljig/L 0.001 ng/L USEPA 1999
0.086 ng/L 0.036 ng/L USEPA 1999
0.52 (ig/L 0.0038 (ig/L USEPA 1999
                                                                                                                            Page 130

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Table 6. Summary of potential targets for pore-water chemistry.
                              WQ Criteria                           LC50 for                       Invertebrates
Analyte                 	   Reference                      Reference    	      Reference
                            Acute      Chronic                   Hyaletta azteca                   Acute   Chronic

Pesticides (cont.)
  Heptachlor epoxide        0.52 ng/L    0.0038 ng/L USEPA 1999
  Lindane (gamma-BHC)     0.95 ng/L               USEPA 1999

Others
  Phenol
  Ammonia (total)                           *      USEPA 1999

Temperature and pH dependent
                                                                                                                           Page 131

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Table 7. Rating of selection criteria for freshwater sediment toxicity testing organisms (ASTM 2001a; USEPA 2000a).
                                                                                                                       Daphnia spp.
   .   .                   Hyalella   Diporeia  Chironomus   Chironomus  Lumbriculus  Tubifex  Hexagenia                 and
                           azteca      spp.      tentans       riparius      variegatus    tubifex     spp.     Molluscs  Ceriodaphnia
                                                                                                                            spp.
Relative sensitivity toxicity
database
Round-robin studies
conducted
Contact with sediment + +
Laboratory culture +
Taxonomic identification + +/-
Ecological importance + +
Geographical distribution + +/-
Sediment physicochemical
tolerance
Response confirmed with
benthos populations
Peer reviewed + +
Endpoints monitored S,G,M S,B,A
Overall Assessment 10+ 5+
+ - +
+ . -----
+ + + + + + -
+ + + + - - +
+/- +/- + + + + +
+ + + + + + +
+ + ++ + + +/-
+/- + + + - + NA
+
+ + ++ + -+/-
S,G,E S,G,E B,S S,R S,G B S,G,R
8+ 7+ 9+ 8+ 5+ 5+ 4+
"+" or "-" rating indicates a positive or negative attribute;  NA = not applicable.
S - survival; G = growth; M = maturation; E = emergence; B = bioaccumulation; R = reproduction.
                                                                                                                             Page 132

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Table 8.  Summary of standard methods for conducting whole-sediment toxicity or sediment bioaccumulation tests with freshwater
          invertebrates.
Species
Hyalella azteca
Hyalella azteca
Diporeia spp.
Chironomus tentans
Chironomus tentans a
Chironomus riparius
Chironomus riparius a
Daphnia magna or
Ceriodaphnia dubia
Hexagenia spp.
Tubifex tubifex
Lumbriculus variegatus a
Common Duration of _ . _, , .
_ , , ^ Primary Endpomts
Name Exposure (days)
Amphipod
Amphipod
Amphipods
Midge
Midge
Midge
Midge
Cladocerans
Mayflies
Oligochaete
Oligochaete
10 to 14
28 to 42
28
10 to 14
20 to 60
10 to 14
30
7
21
28
28
Survival and growth
Survival, growth, and reproduction
Survival and bioaccumulation
Survival, emergence, and
growth
Survival, growth, emergence,
and reproduction
Survival and growth
Survival, growth, and emergence
Survival and reproduction
Survival and growth
Survival and reproduction
Bioaccumulation
Matching Chemistry
Standard Method b
and Toxicity Data
ASTM (200 Ib); Environment
Canada (1997a); USEPA (2000b)
ASTM (200 Ib); USEPA (2000b)
ASTM (200 Ib)
ASTM (200 Ib); Environment
Canada (1997b); USEPA (2000b)
ASTM (200 Ib); USEPA (2000b)
Environment Canada (1997b)
ASTM (200 Ib)
ASTM (200 Ib)
ASTM (200 Ib)
ASTM (200 Ib)
ASTM (200 Id); USEPA (2000b)
673 and 670
165 and 160
Not reported
556 and 557
Not reported
76 and 81
Not reported
8
112
Not reported
Not reported
3OECD is currently developing standard methods for conducting sediment tests with these species (tests with Chironomusyoshimatsui are also being developed).
bNumber of samples with matching sediment chemistry and toxicity in a national database described in USEPA (2000b).
                                                                                                                                      Page 133

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Table 9. Advantages and disadvantages of laboratory sediment toxicity tests (ASTM 2001a; USEPA 2000a).
Advantages
Disadvantages
  Measure bioavailable fraction of contaminant(s).

  Provide a direct measure of benthic effects, assuming no field
  adaptation or amelioration of effects.

  Limited special equipment is required.
  Methods are rapid and inexpensive.

  Legal and scientific precedence exist for use; ASTM standard guides
  are available.
  Measure unique information relative to chemical analyses or benthic
  community analyses.

  Tests with spiked chemicals provide data on cause-effect relationships.

  Sediment-toxicity tests can be applied to all COPCs.


  Tests applied to field samples reflect cumulative effects of
  contaminants and contaminant interactions.

  Toxicity tests are amenable to confirmation with natural benthos
  populations.
*  Sediment collection, handling, and storage can alter sediment toxicity.

*  Spiked sediment may not be representative of field-contaminated sediment.


*  Natural geochemical characteristics of sediment may affect the response of
   test organisms.

*  Indigenous animals may be present in field-collected sediments.

*  Route of exposure may be uncertain and data generated in sediment toxicity
   tests may be difficult to interpret if factors controlling the bioavailability of
   contaminants in sediment are  unknown.

*  Tests applied to field samples may not discriminate effects of individual
   chemicals.

*  Few comparisons have been made of methods or species.

*  Only a few chronic methods for measuring sublethal effects have been
   developed or extensively evaluated.

*  Laboratory tests have inherent limitations in predicting ecological effects.


*  Tests do not directly address human health effects.
                                                                                                                                     Page 134

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Table 10.  Test conditions for conducting 28- to 42-day sediment toxicity test with Hyalella azteca (ASTM 2001a; USEPA 2000a).
Parameter
Conditions
Test type

Temperature

Light quality

Illuminance

Photoperiod

Test chamber

Sediment volume

Overlying water volume


Renewal of overlying water

Age of organisms

Number of organisms/chamber

Number of replicate
chambers/treatment
Whole-sediment toxicity test with renewal of overlying water.

23 ± 1°C.

Wide-spectrum fluorescent lights.

About 100 to 1000 lux.

16L:8D.

300-mL high-form lipless beaker.

100 Ml.

175 mL in the sediment exposure from Day 0 to Day 28 (175 to 275 mL in the water-only exposure from Day 28
to Day 42).

2 volume additions/d; continuous or intermittent (e.g., one volume addition every 12 h).

7- to 8-d old at the start of the test.

10

12 (4 for 28-day survival and growth and 8 for 35- and 42-day survival, growth, and reproduction). Reproduction is
more variable than growth or survival; hence, more replicates might be needed to establish statistical differences among
treatments.
                                                                                                                                 Page 135

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Table 10.  Test conditions for conducting 28- to 42-day sediment toxicity test with Hyalella azteca (ASTM 2001a; USEPA 2000a).
Parameter
Conditions
Feeding

Aeration

Overlying water

Test chamber cleaning

Overlying water quality
Test duration

Endpoints


Test acceptability
YCT food, fed 1.0 mL (1800 mg/L stock) daily to each test chamber.

None, unless dissolved oxygen in overlying water drops below 2.5 mg/L.

Culture water, well water, surface water or site water.  Use of reconstituted water is not recommended.

If screens become clogged during a test; gently brush the outside of the screen.

Hardness, alkalinity, conductivity, and ammonia at the beginning and end of a sediment exposure (Day 0 and 28).
Temperature daily.  Conductivity weekly. Dissolved oxygen (DO) and pH three times/week.  Concentrations of DO
should be measured more often if DO drops more than 1 mg/L since the previous measurement.

42 days.

28-day survival and growth; 35- and 42-day survival, growth, reproduction, and number of adult males and females on
Day 42.

Minimum mean control survival of 80% on Day 28. Additional performance-based criteria specifications are outlined
in Table 11 and in round-robin.
                                                                                                                                  Page 136

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Table 11. Test acceptability requirements for a 42-day sediment toxicity test with Hyaletta azteca (ASTM 2001a; USEPA 2000a).
It is recommended for conducting the 42-day test
with Hyalella azteca that the following
performance criteria be met:
Performance-based criteria for culturing Hyalella
azteca include the following:
* Age of Hyalella azteca  at the start of the test should be 7- to 8-day old. Starting a test with
  substantially younger or older organisms may compromise the reproductive  endpoint.

* Average survival of Hyalella azteca in the control sediment on Day 28 should be greater than or
  equal to 80%.

* Laboratories participating in round-robin testing (ASTM 200la; USEPA 2000a) reported after 28-
  day sediment exposures in a control sediment (West Bearskin), survival >80% for >88% of the
  laboratories; length >3.2 mm/individual for >71% of the laboratories;  and dry weight >0.15
  mg/individual for 66% of the laboratories. Reproduction from Day 28 to Day 42 was >2
  young/female for 71% of the laboratories participating in the round-robin testing. Reproduction
  was more variable within and among laboratories; hence, more replicates might be needed to
  establish statistical differences among treatments with this endpoint.

* Hardness, alkalinity, and ammonia in the overlying water typically should not vary by more than
  50% during the sediment exposure, and dissolved oxygen should be maintained above 2.5 mg/L
  in the overlying water.

* It may be desirable for laboratories to periodically perform 96-hour water-only reference-toxicity
  tests to assess the sensitivity of culture organisms. Data from these reference toxicity tests could
  be used to assess genetic strain or life-stage sensitivity of test organisms to select chemicals.

* Laboratories should track parental survival in the cultures and record this information using
  control charts if known-age cultures are maintained. Records should also be  kept on the frequency
  of restarting cultures and the age of brood organisms.

* Laboratories should record the following water-quality characteristics of the cultures at least
  quarterly: pH, hardness, alkalinity, and ammonia. Dissolved oxygen in the cultures should be
  measured weekly. Temperature in the cultures should be recorded daily. If static cultures are
  used, it may be desirable to measure water quality more frequently.
                                                                                                                                      Page 137

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Table 11. Test acceptability requirements for a 42-day sediment toxicity test with Hyaletta azteca (ASTM 2001a; USEPA 2000a).
Performance-based criteria (cont.)
Additional requirements:
* Laboratories should characterize and monitor background contamination and nutrient quality of
  food if problems are observed in culturing or testing organisms.

* Physiological measurements such as lipid content might provide useful information regarding the
  health of the cultures.

* All organisms in a test must be from the same source.

* Storage of sediments collected from the field should follow guidance outlined in ASTM (2000a)
  and in USEPA (2000a).

* All test chambers (and compartments) should be identical and should contain the same amount
  of sediment and overlying water.

* Negative-control sediment and appropriate solvent controls must be included in a test. The
  concentration  of solvent used must not adversely affect test organisms.

* Test organisms must be cultured and tested at 23°C (±1 °C).

* The mean of the daily test temperature must be within ± 1°C of 23°C. The instantaneous
  temperature must always be within ±3°C of 23°C.

* Natural physico-chemical characteristics of test sediment collected from the field should be
  within the tolerance limits of the test organisms.
                                                                                                                                   Page 138

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Table 12.  Uncertainty associated with sediment phases used in laboratory toxicity tests (Ingersoll et al  1997).

Precision
Ecological relevance
Causality: Link
Causality: Source
Sensitivity
Interference
Standardization
Discrimination
Bioavailability
Field validation
Whole Sediment:
Benthos
1
1
3
1
1
2*
1
1*
1*
1*
Whole Sediment:
Pelagic
1
2
3
2
2
2
2
1*
1*
2*
Organic
Extracts
1
3
3
3*
3
3
3
1*
3
3
Suspended
Solids
3
2
3
3
3
3
3
1*
1*
3*
Elutriates
1
3
3
3
3
3
1
1*
3
3
Pore Water
1
2
3
2
2
2*
2
1*
1*
3*
Ranking Code: 1 = low uncertainty (good); 3 = high (bad); * = lack of knowledge.
                                                                                                                                  Page 139

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Table 13. Uncertainty associated with endpoints measured in laboratory toxicity tests with sediment (Ingersoll et al  1997).

Precision
Ecological relevance
Causality: Link
Causality: Source
Sensitivity
Interference
Standardization
Discrimination
Bioavailability
Field validation
Survival
1
1
3
1
1
1*
1
2
1
1
Growth
1*
2*
3
2*
2
2*
2
1
1
2*
Reproduction
2*
1*
3
2*
1
3*
2
1
1
2*
Behavior
1*
2*
3
2*
2
2*
1
2
1
1
Life Tables
3*
1*
3
3*
2*
3*
3
2*
1
3*
Development
1
2*
3
1
2
2*
2*
1
1
2
Biomarkers
3*
3*
2
2
1*
3
3
2*
1
3
Ranking Code: 1 = low uncertainty (good); 3 = high (bad); * = lack of knowledge.
                                                                                                                                Page 140

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Table 14.  Uncertainty associated with benthic community assessments (Ingersoll et al. 1997).

Precision
Ecological relevance
Causality: Contamination
Causality: Source
Sensitivity
Interference
Standardization
Discrimination
Bioavailability
Field validation
Individual
1
3
2*
2*
1*
2*
3*
2
2*
3*
Population
1
2
2*
3*
1
3*
1
1
NA
1
Structure
2
1
2*
3*
2
3*
1
1
NA
1
Function
3*
3*
3*
3*
3*
3*
3*
3*
3*
3*
Ranking Code: 1 = low uncertainty (good); 3 = high (bad); * = lack of knowledge.
NA = not applicable.
                                                                                                                                   Page 141

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Table 15.  Advantages and disadvantages of benthic invertebrate community structure data.
Advantages
Disadvantages
  Provides information that is directly relevant for assessing the status of   *  The distribution and abundance of benthic invertebrates can be influenced
  the benthic community.                                                by non-contaminant related factors (e.g., TOC, grain size).
  Procedures are available to facilitate defensible sampling program
  design.
* Large numbers of samples are needed to address the inherent variability of
  benthic community metrics.
  Resultant data are socially- and ecologically-relevant.

  Limited special equipment is required to support assessments.
* Standard methods for collecting and processing samples are not
  available.
                                                                     *  Identification of organisms to species can be difficult.

                                                                     *  Benthic community data can not be used alone to determine the cause of
                                                                       any effects that are observed.

                                                                     *  There is little agreement on which metrics are the most relevant for use in
                                                                       benthic community assessments.
                                                                                                                                     Page 142

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Table 16. Selection criteria for sediment bioaccumulation test organisms (ASTM 2001d; USEPA 2000a).
Criterion
                                            Lumbnculus
                                             vanegatus
Molluscs   Midges   Mayflies  Amphipods  Cladocerans   Fish
Laboratory culture

Known chemical exposure

Adequate tissue mass

Low sensitivity to contaminants

Feeding not required during testing

Realistic exposure

Sediment physico-chemical tolerance

Response confirmed with benthic populations
                                                                           +/-
"+" or "-" rating indicates a positive or negative attribute.
NA = not applicable; ? = unknown.
                                                   NA
                                                                                                                          NA
Overall assessment
7+
3+ 3+ 3+ 5+
2+
4+
                                                                                                                               Page 143

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Table 17.  Advantages and disadvantages of tissue chemistry data.
Advantages
Disadvantages
* Provides direct information for determining the presence/absence of
  COPCs in tissues.

* Standard methods are available for most COPCs.

* Procedures are available for evaluating the reliability of the data (i.e.,
  accuracy and precision).

* Benchmarks (i.e., TRGs) are available for many COPCs for evaluating
  the potential for biological effects.

* Can be used to identify the COPCs that are causing or substantially
  contributing to adverse effects.
  Can not be used to evaluate effects on ecological receptors directly.

  Generation of high quality data can require substantial sample volumes,
  which is difficult to obtain for small organisms or for areas that have
  depauperate  benthic communities.

  Effective interpretation of the data is dependent on the availability of
  appropriate benchmarks.

  The use of inappropriate methods (e.g., with high detection limits) can
  limit the utility of the resultant data.

  Interferences with the analysis of specific analytes can influence the utility
  of the data (i.e., by resulting in high detection limits).
                                                                                                                                       Page 144

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Table 18. Recommended test conditions for conducting a 28-day sediment bioaccumulation test with Lumbriculus variegatus
          (ASTM 2001d; USEPA 2000a).
Parameter
                                       Conditions
Test type

Temperature

Light quality

Illuminance

Photoperiod

Test chamber

Sediment volume

Overlying water volume

Renewal of overlying water

Age of test organisms

Loading of organisms in chamber
Number of replicate
chambers/treatment
Whole-sediment bioaccumulation test with renewal of overlying water.
23°C.
Wide-spectrum fluorescent lights.
About 100 to lOOOlx.
16L:8D.

4 to 6-L aquaria with stainless steel screens or glass standpipes.

1 L or more depending on TOC.

1 L or more depending on TOC.

2 volume additions/day; continuous or intermittent (for example, one volume addition every 12 h).

Adults.

Ratio of TOC in sediment to organism dry weight should be no less than about 50:1; minimum of 1
g/replicate;  preferably 5 g/replicate.

Depends on the objective of the test. Five replicates are recommended for routine testing.
                                                                                                                               Page 145

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Table 18. Recommended test conditions for conducting a 28-day sediment bioaccumulation test with Lumbriculus variegatus
          (ASTM 2001d; USEPA 2000a).
Parameter
                                        Conditions
Feeding

Aeration

Overlying water

Test chamber cleaning

Overlying water quality


Test duration

Endpoint

Test acceptability
None.

None, unless dissolved oxygen in overlying water drops below 2.5 mg/L.

Culture water, well water, surface water, site water, or reconstituted water.

If screens become clogged during the test, gently brush the outside of the screen.

Hardness, alkalinity, conductivity, pH, and ammonia at the beginning and end of a test temperature and
dissolved oxygen daily.

28 days.

Bioaccumulation.

Performance-based criteria specifications outlined in Table  19.
                                                                                                                                Page 146

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Table 19. Test acceptability requirements for a 28-day sediment bioaccumulation test with the oligochaete, Lumbriculus variegatus
           (ASTM 2001d; USEPA 2000a).
It is recommended for conducting a 28-day  * Numbers of Lumbriculus variegatus in a 4-day toxicity screening test should not be reduced
test with Lumbriculus variegatus  that the     significantly in the test sediment relative to the control sediment.
following performance criteria are met:
                                        * Test organisms should burrow into test sediment. Avoidance of the test sediment by Lumbriculus
                                          variegatus may decrease bioaccumulation.

                                        * The hardness, alkalinity, pH, and ammonia of overlying water within a treatment typically should not
                                          vary by more than 50 % during the test and dissolved oxygen should be maintained above 2.5 mg/L in
Performance-based criteria for culturing
Lumbriculus variegatus include the
following:
 the overlying water.

* It may be desirable for laboratories to perform periodically 96-hour water-only reference toxicity tests
 to assess the sensitivity of culture organisms. Data from these reference toxicity tests could be used to
 assess genetic strain or life-stage sensitivity of test organisms to select chemicals.

* Laboratories should monitor the frequency with which the population is doubling in the culture (the
 number of organisms) and record this information using control charts (the doubling rate would need to
 be estimated on a subset of animals from a mass culture). Records also should  be kept on the frequency
 of restarting cultures. If static cultures are used, it may be desirable to measure water quality more
 frequently.

* Food used to culture organisms should be analyzed before the start of a test for compounds to be
 evaluated in the bioaccumulation test.

* Laboratories should record the following water quality characteristics of the cultures at least quarterly
 and the day before the start of a sediment test: pH, hardness, alkalinity, and ammonia.  Dissolved oxygen
 in the cultures should be measured weekly. Temperatures of the cultures should be recorded daily.

* Laboratories should characterize and monitor the background contamination and nutrient quality of food
 if problems are observed in culturing or testing organisms.
                                                                                                                                      Page 147

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Table 19.  Test acceptability requirements for a 28-day sediment bioaccumulation test with the oligochaete, Lumbriculus variegatus
           (ASTM 2001d; USEPA 2000a).
Performance-based criteria (cont.)
Additional requirements:
* Physiological measurements such as lipid content might provide useful information regarding the health
  of the  cultures.

* All organisms in a test must be from the same source.

* Storage of sediment collected from the field should follow guidance outlined in ASTM (2001).

* All test chambers (and compartments) should be identical and should contain the same amount of
  sediment and overlying water.

* Negative-control sediment or appropriate solvent controls, must be included in a test. The concentration
  of solvent used must not affect test organisms adversely.

* Culture and test temperatures must be the same. Acclimation of test organisms to the test water is not
  required.

* The daily mean test temperature must be within ±1°C of the desired temperature. The instantaneous
  temperature must always be within ±3°C of the desired temperature.

* Natural physicochemical characteristics of test sediment collected from the field should be within the
  tolerance limits of the test organisms.
                                                                                                                                  Page 148

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Table 20.  Uncertainty associated with bioaccumulation assessments (Ingersoll et al  1997).

Precision
Ecological relevance: Protection of ecology
Ecological relevance: Protection of human health
Causality: Source identification
Causality: Sensitivity (detection limit)
Interferences
Standardization
Discrimination
Bioavailability
Field validation
Laboratory
1
3
1
1
1
2
1
1
1
2*
Field
2
3
1
3
2
2*
1
1
1
1
Food Web
3
3
1
3
3*
NA
2
1
1
2*
Models
3
3
1
1
3*
NA
2
1
1
2*
Ranking Code: 1 = low uncertainty (good); 3 = high (bad); * = lack of knowledge.
NA = not applicable.
                                                                                                                                   Page 149

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Table 21.  Methods for evaluating the effects of exposure to COPCs in fish (from Schmitt et al. 2000).
Method
Description
                                                                    Tissue(s)
                                                                    Examined
                                                         Sensitivity
Reference
Histopathology
Microscopic examination for the
presence of lesions; can provide early
indication of chemical exposure
                                                                    Liver, gill, gonads,   Overall organism health   Hintonetal.  1992;Hinton
                                                                    spleen, and kidney   and contaminants        1993; Goodbred et al.  1997
Ethoxyresorufin-0 -deethylase
(EROD) activity

Lysozyme activity
Enzyme induction by planar            Liver
hydrocarbons

A disease resistance factor that          Blood plasma
can be suppressed in the presence
of contaminants
                                                                                         PCBs, PAHs, dioxins,
                                                                                         and furans
                                                                                PohlandFouts 1980;
                                                                                Kennedy and Jones 1994
                                                                                         Overall organism health  Blazer et al. 1994a
Macrophage aggregate analysis
Macrophages are important in the
immune system, serving as a first line
of defense for the organism
and as an antigen processing cell
                                                                    Spleen, hemopoetic   Multiple contaminants    Blazer et al. 1994a;
                                                                    kidney, and liver     including PAHs and      Blazer et al. 1997
                                                                                        metals
H4IIE bioassay
A screening tool to determine the        Whole fish
presence of certain classes of           (composites)
planar halogenated compounds
                                                                                        PCBs, dioxins, furans,    Tillittetal.  1991
                                                                                        and PAHs
Vitellogenin
Sex Steroids (estradiol and
testosterone)
                               A precursor of egg yolk, normally       Blood plasma
                               synthesized in the liver of female fish

                               Determine reproductive health and       Blood plasma
                               status
                                                         Endocrine modulating
                                                         compounds

                                                         Endocrine modulating
                                                         compounds
                                                                                Folmaretal.  1996
                                                                                Guilleteetal.  1994;
                                                                                Goodbred et al. 1997
                                                                                                                                   Page 150

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Table 21.  Methods for evaluating the effects of exposure to COPCs in fish (from Schmitt et al. 2000).
Method
Chemical analyses
Somatic indices
Stable N isotopes (14N and 15N)
Description
Organochlorine chemical residues
and elemental contaminants
The relative mass of some organs
is often indicative of chemical exposure
The ratio of (15N to 14N) (d15N)
increases with trophic position and
Tissue(s)
Examined
Whole fish
(composites)
Gonads, spleen,
liver
Whole fish
(composites)
Sensitivity
Specific analytes
Overall organism health
Trophic position,
nitrogen sources
Reference
Schmitt et al.
Grady et al.
Grady et al.

1999
1992
1996
Necropsy-based fish health
assessment
sewage pollution

Visual assessment of external/internal
anomalies (e.g., lesions, parasites,
tumors), which may indicate
contaminant-related stress
All
Overall organism health  Goede 1988; 1996; Adams
                       1990; Adams et al. 1993
                                                                                                                                 Page 151

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Table 22.  Methodological uncertainty associated with fish health and fish community assessments.
                                                  Fish Health                     Fish Community
Precision
Ecological relevance
Causality
Sensitivity
Interference
Standardization
Discrimination
Bioavailability
Field validation
1
2
1
2
3
2
1
1
2
2
1
3
2
3
2
3
3
2
Ranking Code: 1 = low uncertainty (good); 3 = high (bad).
                                                                                                                             Page 152

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Table 23.  Contingency table for assessing impacts of contaminated sediments on aquatic life based on three separate indicators of

           sediment quality (sediment quality triad adapted from Chapman 1992 and Canfield et al  1996).





 Possible   Sediment  Toxicity    Benthic                                        _    .,,  _   ,  .
 _.          ,_,           _      „.        .                                        Possible Conclusions
 Outcome Chemistry   Test    Community





     1          +          +          +      Impact highly likely: Contaminant-induced degradation of sediment-dwelling organisms evident.



     2          -          -          -      Impact highly unlikely: Contaminant-induced degradation of sediment dwelling organisms not evident.



     3          +          -          -      Impact unlikely: Contaminants unavailable to sediment-dwelling organisms.



     4          -          +          -      Impacts possible: Unmeasured contaminants or conditions exist that have the potential to cause degradation.



     5          -          -          +      Impacts unlikely: No degradation of sediment-dwelling organisms in the field apparent relative to sediment

                                             contamination; physical factors may be influencing benthic community.



     6          +          +          -      Impact likely: Toxic chemicals probably stressing the system.



     7          -          +          +      Impact likely: Unmeasured toxic chemicals are probably contributing to the toxicity.



     8          +          -          +      Impact likely: Sediment-dwelling organisms degraded by toxic chemicals, but toxicity tests not sensitive to

                                             chemicals present.





 + = Indicator classified as affected; as determined based on comparison to the established target.

 - = Indicator not classified as affected; as determined based on comparison to the established target.
                                                                                                                                    Page 153

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Table 24.  Contingency table for assessing impacts of contaminated sediments on aquatic life based on four separate indicators of
           sediment quality.


 Possible   Sediment  Toxicity   Benthic     Tissue                                   _,   .,,  „,    ,   .
 „  ,        „,    . ,      „  ,    „         .,   „,    .  ,                                    Possible Conclusions
 Outcome Chemistry   Test   Community Chemistry


     1          +         +          +           +      Contaminant-induced impacts on sediment-dwelling organisms and higher trophic levels are
                                                          likely to be observed; elevated levels of sediment-associated contaminants are likely
                                                          contributing to sediment toxicity and benthic community impairment; and, bioaccumulation of
                                                          sediment-associated contaminants has the potential to adversely affect aquatic-dependent
                                                          wildlife and/or human health.

     2          -          -          -            +      Contaminant-induced impacts on higher trophic levels are likely to be observed; adverse effects
                                                          on sediment-dwelling organisms are unlikely to be observed; and, bioaccumulation of sediment-
                                                          associated contaminants has the potential to adversely affect aquatic-dependent wildlife and/or
                                                          human health.

     3          +         -          -            +      Contaminant-induced impacts on higher trophic levels are likely to be observed; the
                                                          bioavailability of sediment-associated contaminants is likely to be limited; and,
                                                          bioaccumulation of sediment-associated contaminants has the potential to adversely affect
                                                          aquatic-dependent wildlife and/or human health.

     4          -          +          -            +      Contaminant-induced impacts on higher trophic levels are likely to be observed; unmeasured
                                                          factors (e.g., physical factors or contaminants) are likely to be contributing to sediment
                                                          toxicity; and, bioaccumulation of sediment-associated contaminants has the potential to
                                                          adversely affect aquatic-dependent wildlife and/or human health.

     5          -          -          +           +      Contaminant-induced impacts on sediment-dwelling organisms and higher trophic levels are
                                                          likely to be observed; adverse effects on sediment-dwelling organisms are likely due to
                                                          physical factors and/or unmeasured chemicals are stressing benthos and toxicity tests are not
                                                          sensitive enough to detect effects; and, bioaccumulation of sediment-associated contaminants
                                                          has the potential to adversely affect aquatic-dependent wildlife and/or human health.


                                                                                                                                      Page 154

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Table 24.  Contingency table for assessing impacts of contaminated sediments on aquatic life based on four separate indicators of
           sediment quality.


 Possible   Sediment  Toxicity    Benthic      Tissue                                   _,   .,,  „,   ,  .
 „  ,       „,    . ,      „  ,    „        .,   „,    .  ,                                   Possible Conclusions
 Outcome Chemistry   Test   Community Chemistry


     6          +         +          -            +     Contaminant-induced impacts on sediment-dwelling organisms and higher trophic levels are
                                                         likely to be observed; high variability in the benthic community metrics may be masking
                                                         contaminant-related effects; and, bioaccumulation of sediment-associated contaminants has the
                                                         potential to adversely affect aquatic-dependent wildlife and/or human health.

     7          -          +          +            +     Contaminant-induced impacts on sediment-dwelling organisms and higher trophic levels are
                                                         likely to be observed; unmeasured contaminants are likely contributing to sediment toxicity and
                                                         benthic impairment; and, bioaccumulation of sediment-associated contaminants has the
                                                         potential to adversely affect aquatic-dependent wildlife and/or human health.

     8          +         -          +            +     Contaminant-induced impacts on sediment-dwelling organisms and higher trophic levels are
                                                         likely to be observed; toxicity tests are not sensitive enough to detect adverse effects; and,
                                                         bioaccumulation of sediment-associated contaminants has the potential to adversely affect
                                                         aquatic-dependent wildlife and/or human health.

     9          +         +          +            -      Contaminant-induced impacts on sediment-dwelling organisms are likely to be observed;
                                                         elevated levels of sediment-associated contaminants are likely contributing to sediment toxicity
                                                         and benthic community impairment; and, bioaccumulation of sediment-associated contaminants
                                                         is unlikely to be adversely affect aquatic-dependent wildlife and/or human health.

    10          -          -          -            -      Contaminant-induced impacts are unlikely to be observed; sediment-associated contaminants
                                                         are unlikely to adversely affect sediment-dwelling organisms; and, bioaccumulation of sediment-
                                                         associated contaminants is unlikely to adversely affect aquatic-dependent wildlife and/or human
                                                         health.
                                                                                                                                     Page 155

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Table 24.  Contingency table for assessing impacts of contaminated sediments on aquatic life based on four separate indicators of
           sediment quality.


 Possible   Sediment  Toxicity    Benthic      Tissue                                   _,   .,,  „,    ,   .
 „  ,       „,    . ,      „  ,    „        .,   „,    .  ,                                   Possible Conclusions
 Outcome Chemistry   Test   Community Chemistry


    11          +         -          -            -      Contaminant-induced impacts are unlikely to be observed; the bioavailability of sediment-
                                                         associated contaminants is likely to be limited; and, bioaccumulation of sediment-associated
                                                         contaminants is unlikely to adversely affect aquatic-dependent wildlife and/or human health.

    12          -          +          -            -      Contaminant-induced impacts are unlikely to be observed, based on the COPCs that were
                                                         evaluated; Unmeasured factors (e.g., physical factors or contaminants) are likely to be
                                                         contributing to sediment toxicity; and, bioaccumulation of sediment-associated contaminants is
                                                         unlikely to adversely affect aquatic-dependent wildlife and/or human health.

    13          -          -          +            -      Contaminant-induced impacts on sediment-dwelling organisms are unlikely to be observed,
                                                         based on the COPCs that were evaluated; adverse effects on sediment-dwelling  organisms are
                                                         likely due to physical factors and/or unmeasured chemicals are stressing benthos and toxicity
                                                         tests are not sensitive enough to detect effects; and, bioaccumulation of sediment-associated
                                                         contaminants is unlikely to adversely affect aquatic-dependent wildlife and/or human health.

    14          +         +          -            -      Contaminant-induced impacts on sediment-dwelling organisms are likely to be observed; high
                                                         variability in the benthic community metrics may be masking contaminant-related effects; and,
                                                         bioaccumulation of sediment-associated contaminants is unlikely to adversely affect aquatic-
                                                         dependent wildlife and/or human health.

    15          -          +          +            -      Contaminant-induced impacts on sediment-dwelling organisms are likely to be observed, based
                                                         on the COPCs that were evaluated; unmeasured contaminants are likely contributing to
                                                         sediment toxicity and benthic impairment; and, bioaccumulation of sediment-associated
                                                         contaminants is unlikely to adversely affect aquatic-dependent wildlife and/or human health.
                                                                                                                                     Page 156

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Table 24.  Contingency table for assessing impacts of contaminated sediments on aquatic life based on four separate indicators of
           sediment quality.


 Possible   Sediment  Toxicity    Benthic      Tissue                                   _,   .,,   „,    ,   .
 „  ,       „,    . ,      „  ,   „        .,   „,   . ,                                    Possible Conclusions
 Outcome Chemistry   Test   Community  Chemistry


    16          +         -           +            -      Contaminant-induced impacts on sediment-dwelling organisms are likely to be observed;
                                                         toxicity tests are not sensitive enough to detect adverse effects; and, bioaccumulation of
                                                         sediment-associated contaminants is unlikely to adversely affect aquatic-dependent wildlife
                                                         and/or human health.

 + = Indicator classified as affected; as determined based on comparison to the established target.
 - = Indicator not classified as affected; as determined based on comparison to the established target.
                                                                                                                                    Page 157

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Table 25.  Contingency table for assessing impacts of contaminated sediments on aquatic life based on two separate indicators of
           sediment quality.
 Possible     Sediment      Sediment
 Outcome   Chemistry     Toxicity
                                           Possible Conclusions
     1

     2

     3
+       Impact likely: Contaminant-induced degradation of sediment-dwelling organisms evident.

        Impact unlikely: Contaminant-induced degradation of sediment-dwelling organisms not evident.

        Impact unlikely: Chemicals not readily available to sediment-dwelling organisms, sediment quality
        target set too low, or toxicity test not sensitive enough.

+       Impact likely: Observed effects likely due to unmeasured contaminants or physical factors.
+ = Indicator classified as affected; as determined based on comparison to the established target.
- = Indicator not classified as affected; as determined based on comparison to the established target.
                                                                                                                                   Page 158

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Table 26.  Contingency table for assessing impacts of contaminated sediments on wildlife based on three separate indicators of
           sediment quality.


 Possible   Sediment     Fish       Tissue                                  _,   .,,  „,    ,   .
                                           .                                    Possible Conclusions
 Outcome Chemistry  Community  Chemistry


     1          +           +           +     Impact likely: Contaminant-induced effects  on wildlife in the field and bioaccumulation
                                                evident.

     2          -            -           -      Impact unlikely: Contaminant-induced effects on wildlife in the field not evident; limited
                                                bioaccumulation.

     3          +           -           -      Impact unlikely: Contaminants unavailable to wildlife in the field.

     4          -            +           -      Impact unlikely: Effects on wildlife in the field probably not due to sediment contamination;
                                                limited bioaccumulation.

     5          -            -           +     Impact unlikely: No degradation of wildlife in the field apparent relative to sediment
                                                contamination; tissue residues due to exposure from other media and/or sites.

                                                Impact likely: Contaminant induced effects on wildlife in the field; bioaccumulative
                                                substances not contributing to effects.

     7          -            +           +     Impact unlikely: Effects on wildlife in the field probably not due to contaminated sediment;
                                                bioaccumulation may be occurring due to exposure at other sites.

     8          +           -           +     Impact likely: Contaminants not toxic to wildlife, but bioaccumulation is occurring.


 + = Indicator classified as affected; as determined based on comparison to the established target.
 - = Indicator not classified as affected; as determined based on comparison to the established target.
                                                                                                                                     Page 159

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Table 27.  Contingency table for assessing impacts of contaminated sediments on human health based on two separate indicators of
           sediment quality.


 Possible   Sediment    Tissue                                              _    .,,   _    ,   .
 _.          ,_,    .     ,_,                                                     Possible Conclusions
 Outcome Chemistry Chemistry


     1          +          +      Impact likely: Elevated sediment chemistry and tissue residues resulting in potential adverse dietary affects on human
                                   health.

     2          -           -      Impact unlikely: Sediment chemistry and tissue residues low, with limited potential of adverse dietary affects on human
                                   health.

     3          +          -      Impact possible: Sediment chemistry elevated to level that may result in potential adverse dietary affects on human
                                   health, but organisms sampled for tissue chemistry may not be exposed to sediments at the site or contaminants are not
                                   readily available.

     4          -           +      Impact possible: Elevated tissue residues resulting in potential adverse dietary affects on human health, but organisms
                                   are probably not exposed to sediments at the site.


 + = Indicator classified as affected; as determined based on comparison to the established target.
 - = Indicator not classified as affected; as determined based on comparison to the established target.
                                                                                                                                     Page 160

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Figures

-------
Figure 1. Recommended procedure for assessing sediment chemistry data.
           Assemble Sediment Chemistry
                      Data
         Evaluate Sediment Chemistry Data
          Using Data Quality Objectives in
         Quality Assurance Project Plan (see
                  Appendix 8.1)
                              DQOs met
           Compare Sediment Chemistry
            Data to Background Levels
                              >BKGD
           Compare Sediment Chemistry
             Data to Sediment Qualtiy
                   Guidelines
                           >SQGs
          Sediments Contain Elevated and
          Potentially Hazardous Levels of
                  Contaminants
           Consider Sediment Chemistry
             Data with Data on Other
           Indicators (see Section 7.1 of
                  Volume III)
 DQOs Not
   Met
             Repeat Necessary Components of
               Sampling and Analysis Plan
                                          
-------
Figure 2.  Relationship between mean PEC quotients and the incidence of toxicity in
           freshwater toxicity tests (USEPA 2000b).
         (A) 10-to 14-d Hyalella azteca

               100 -i
               80 H
               60 H

           •5
            g  40 -]
            c
            0)
               20 H
                0 -
                                                                 Survival or growth
                                                             —v--Survival only
                 0.01
                               0.1
                                                          10
                                                                        100
         (B) 28- to 42-d Hyalella azteca
               100 -i
                 0.01
          (C) 10- to 14-d Chironomus spp.

              100 -i
                                                          10
                                                                        100
            o
               80 H
               60 H
            ai  40 -
            c
            0)
            i  20-


                0 -
                                                         r2=0.56
                                                                  1^=0.76
                 0.01
                               0.1            1             10

                                 Geometric mean of mean PEC-Q
                                                                        100
                                                                                          Page 163

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Figure 3. Recommended procedure for assessing sediment toxicity data.
        Assemble Sediment Toxicity Data
     Evaluate Sediment Toxicity Data Using
       Data Quality Objectives in Quality
     Assurance Project Plan (see Chapter 6
                  Volume II)
 DQOs
Not Met
Repeat Necessary Components of
   Sampling and Analysis Plan
                         DQOs Met
       Compare Sediment Toxicity Data to
               Negative Control
                                              Not
                                             Toxic
            Sediments Unlikely Not Signifigantly
                           Toxic
                         Toxic
       Compare Sediment Toxicity Data to
              Reference Station(s)a
                                             Not
                                            Toxic
               Sediments Unlikely to be Toxic
               Relative to Reference Conditions
                         Toxic
        Sediments are Toxic to Sediment-
              Dwelling Organisms
        Consider Sediment Toxicity Data
                with Other Data
         (see Section 7.1 of Volume III)
Comparison to reference sites is only appropriate if reference sites have been well charactized and satisfy criteria for
negative controls (i.e., response in reference sediments should not be significantly different from that in negative
controls).
                                                                                       Page 164

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Figure 4. Recommended procedure for assessing benthic invertebrate or fish
          community structure.
             Assemble Data on Community
                      Structure
           Evaluate Data Using Data Quality
            Objectives in Quality Assurance
                     Project Plan
                                               DQOs
                                              Not Met
    Repeat Necessary
Components of Sampling
        Program
                           DQOs
                            Met
              Compare Data to Reference
                      Station(s)3
                                               Not
                                             Different
Community Unlikely to be
        Degraded
                           Different
           Degraded Community Evident in
              Sediments from Test Station
            Consider Community Structure
          Data with Data on Other Indicators
             (see Section 7.1 of Volume III)
Comparison to reference sites is only appropriate if reference sites have been well charactized and satisfy
criteria for negative controls (i.e., response in reference sediments should not be significantly different
from that in negative controls).
                                                                                         Page 165

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Figure 5.  Recommended procedure for assessing tissue chemistry data.
         Assemble Tissue Chemistry Data
       Evaluate Tissue Chemistry Data Using
        Data Quality Objectives in Quality
       Assurance Project Plan (see Chapter 6
                   Volume II)
 DOOs
Not Met
Repeat Necessary Components of
      Sampling Program
                         Met
        Compare Tissue Chemistry Data to
        Contemporary Background Levels
                                           BKGD
        Compare Tissue Chemistry Data to
            Tissue Residue Guidelines
                                           TRGs
           Tissues Contain Elevated and
        Hazardous Levels of Contaminants
       Consider Tissue Chemistry Data with
       Data on Other Indicators (see Section
                7.1 of Volume III)
                                                                                  Page 166

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Figure 6.  Recommended procedure for evaluating fish health data.
            Assemble Fish Health Data
         Evaluate Fish Helath Data Using
        Data Quality Objectives in Quality
             Assurance Project Plan
 DQOs
Not Met
           Repeat Necessary Components of
                  Sampling Program
                         DQOs
                          Met
           Compare Fish Health Data to
             Reference Data from the
                Assessment Area
   Not
 Different
  Fish Health Unlikely to be
Adversely Affected Relative to
 Reference Conditions at the
      Assessment Area
                         Different
        Fish Health Likely to Be Adversely
          Affected Relative to Reference
        Conditions at the Assessment Area
          Consider Fish Health Data with
           Data on Other Indicators (see
             Section 7.1 of Volume III)
                                                                                        Page 167

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Figure 7.   The relationship between the mean PEC quotient and the response ofHyalella

           azteca in the 10-day tests (as percent survival) or the response in the Microtox®

           solid-phase sediment toxicity test (as the EC50 expressed as a toxicity reference

           index). Sediment samples were collected from the Grand Calumet River and

           Indiana Harbor Canal located in northwestern Indiana (Ingersoll et al  2002).
       ra

       'E
       3
       5

       fi
       CO
       •2
       "35

       I
       I
       •S
       0)
       o
       c
       SJ
       •2
       SJ
       I
       s
       o
           100
30


25


20


^5


10


 5


 0
                                    o   o
                                                      t2 = 0.75
                                                      P< 0.001
                                          y=a/(1+exp(-(x-x0)/b))
                    0.1
                                       10
                           100
      r2 = 0.43
      P= 0.03
                                             y=y0+ax°
° O  CD
                    0.1
                         1              10

                     Mean PEC quotient
                           100
                                                                                Page 168

-------
Figure 8. The relationship between the molar concentration of simultaneously extracted metals to acid volatile
         sulfide (SEM-AVS) and toxic units of metals in the sediment samples. Toxicity of samples was
         determined using 10-day whole-sediment tests with Hyalella azteca (Ingersoll et al.  2002).




C/)
.2
"CD
E
M—
O
c/)
'c
^

X
o
1—
1




1f\f\f\
000 -


100 -


10 -

.



0.1 -

0.01 -
Onm
.UU I
-1(



• Toxic to amphipods
O Non-toxic to amphipods



•

0 • ^
o o ° o 0 °F
0 * o 0« *

• •
o *
o •
/ /
III II S / I
30 -120 -80 -40 0 40 80 400 480
SEM-AVS (umole/g)
                                                                                                                   Page 169

-------
Figure 9. Tri-axial graphs of sediment quality triad data (Canfield et al.  1994; C = chemistry, T = toxicity,

         and B = benthic community; see Section 7.1 of Volume II for description of metrics).
             Milltown
             Reservoir
                   O       20      4O
                        kilometers

                   "  Sampling Stations
                                                                     Warm Springs Ponds
                                                                                                               Page 170

-------
Appendices

-------
                                             APPENDIX 1 -RECOMMENDED UsEsopSQGs - PAGE 172
Appendix 1.  Recommended  Uses  of  Sediment Quality
                   Guidelines
A 1.0 Introduction
      Selection of the most appropriate SQGs for specific applications can be a daunting task for
      sediment assessors.  This task is particularly challenging because  limited guidance is
      currently available on the recommended uses of the various SQGs (Wenning and Ingersoll
      2002).  The following sections provide information on the recommended uses of SQGs in
      the assessment and management of contaminated sediments. Some of the recommended uses
      of SQGs at contaminated sites include:

         •   Designing monitoring programs;

         •   Interpreting sediment chemistry data;

         •   Support for analysis of dredged material disposal options;

         •   Assessing the risks to biotic receptors associated with contaminated sediments;
             and,

         •   Developing site-specific sediment quality remediation objectives.


      Each of these uses of SQGs are discussed in the following sections of this appendix.
A 1.1 Monitoring Program Design
      Monitoring is an integral component of environmental surveillance programs. While such
      programs may be undertaken for a number of reasons (e.g., trend assessment, impact
      assessment, compliance), limitations on available resources dictate that they should be
      conducted in an effective and efficient manner. For this reason, it is important that sediment

      GUIDANCE MANUAL TO SUPPORT THE ASSESSMENT OF CONTAMINATED SEDIMENTS IN FRESHWATER ECOSYSTEMS-VOLUME III

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                                                 APPENDIX 1 -RECOMMENDED UsEsopSQGs - PAGE 173
       quality monitoring programs be well focused and provide the type of information that is
       necessary to manage contaminated sediments.

       Sediment quality guidelines contribute to the design of environmental monitoring programs
       in several  ways. First, comparison of existing sediment chemistry data with the SQGs
       provides a systematic basis for identifying high priority areas for implementing monitoring
       activities.  Second, when used in conjunction with existing sediment chemistry data, the
       SQGs may be utilized to identify chemicals of potential concern (COPCs) within an area of
       concern. By considering the potential sources of these COPCs, it may be possible to further
       identify priority sites for investigation. The SQGs can also assist in monitoring program
       design by establishing target detection limits for each substance [e.g., threshold effect
       concentrations (TECs) in MacDonald et al.  2000b].  Determination of the detection limits
       that need to be achieved by analytical laboratories (i.e., to facilitate subsequent interpretation
       of resultant sediment chemistry data) should help to avoid the difficulties that can result from
       the use of standard, yet inappropriate, analytical methods (e.g., use  of USEPA contract
       laboratory procedures; CLP methods resulting potentially in high detection limits).
A 1.2 Interpretation of Sediment Chemistry Data
       Over the past decade, sediment chemistry data have been collected at a wide range of sites
       for many purposes (Wenning and Ingersoll 2002).  While these data can be used directly to
       assess the status and trends in environmental quality conditions, they do not, by themselves,
       provide a basis for determining if the measured concentrations of contaminants represent
       significant hazards to aquatic organisms.  Sediment quality guidelines provide practical
       assessment tools or "targets" against which the biological significance of sediment chemistry
       data can be assessed.  In this context, SQGs may be used as screening tools to identify areas
       and contaminants  of concern (COCs;  i.e., the substances that are likely to cause or
       subsequently contribute to adverse biological effects) on site-specific, regional, or national
       bases.
      GUIDANCE MANUAL TO SUPPORT THE ASSESSMENT OF CONTAMINATED SEDIMENTS IN FRESHWATER ECOSYSTEMS-VOLUME III

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                                           APPENDIX 1 -RECOMMENDED UsEsopSQGs - PAGE 174
 The numerical SQGs can be used to identify,  rank, and prioritize COCs in freshwater,
 estuarine, and marine sediments.  In this application, the concentration of each substance in
 each sediment sample is compared to the corresponding SQG. Those substances that occur
 at concentrations below threshold effect-type SQGs (i.e., TECs - MacDonald etal. 2000b;
 TELs - Smith et al. 1996; ERLs - USEPA 1996; LELs - Persaud et al. 1993; ESBs - USEPA
 1997;  Appendix 3 of Volume III) should be considered to be of relatively  low priority.
 Those substances that occur at concentrations above the threshold effect-type SQGs but
 below the probable effect-type SQGs (i.e., PECs - MacDonald et al. 2000b; PELs - Smith
 etal. 1996; ERMs - USEPA 1996; SELs - Persaud etal. 1993; Appendix  3 of Volume IE)
 should be considered  to be of moderate concern,  while  those that are  present at
 concentrations in excess of the probable effect-type SQGs should be considered to be of
 relatively high concern.  The relative priority that should be assigned to each  chemical can
 be determined by  evaluating the magnitude and frequency of exceedance of the SQGs.
 Chemicals that frequently exceed the probable effect-type SQGs and/or those that exceed the
 probable effect-type SQGs by large margins should be viewed as the contaminants of greatest
 concern (Long and MacDonald 1998; MacDonald etal. 2000a; 2000b; 2002a; 2002b; 2002c;
 USEPA2000b; Ingersoll etal. 2001; 2002).

 In conducting such assessments, it is important to remember that certain chemicals can be
 present in relatively unavailable forms (such as slag, paint chips, tar). Therefore, there is not
 a 100% certainty that samples with chemical concentrations in excess of the probable effect-
 type concentrations will actually be toxic to sediment-dwelling organisms. Therefore, SQGs
 should be applied with caution in areas with atypical sediment characteristics. Additionally,
 the reliability of the SQGs should also be considered when identifying  COCs, with the
 greatest weight assigned to those  SQGs which have been shown to be highly or moderately
 reliable (USEPA 1996; 2000b; MacDonald etal. 2000a; 2000b).

 The degree of confidence that can be placed in determinations of COCs can be increased by
 collecting ancillary sediment quality information. Specifically, data on regional background
 concentrations of sediment-associated contaminants can be used to identify substances of
 relatively low concern with respect to anthropogenic activities (i.e., those substances that
 occur at or below background levels; Appendix 2 of Volume HI). Data from toxicity tests
 can also be used to support the identification of COCs.  In particular, matching sediment
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 chemistry and toxicity data provides a basis  for evaluating the degree of concordance
 between the concentrations of specific contaminants and measured adverse effects (USEPA
 2000b; MacDonald et al. 2002c).   The  degree of concordance between chemical
 concentrations and sediment toxicity can be  evaluated using correlation analyses and
 regression plots (Carr et al.  1996).   Those  substances that are present  at elevated
 concentrations (i.e., as indicated by exceedances of the probable effect-type SQGs) in toxic
 samples should be identified as the contaminants of highest concern (Long and MacDonald
 1998; MacDonald et al. 2000b). Those chemicals that are not positively correlated with the
 results of the toxicity tests should be viewed as relatively lower priority (MacDonald et al.
 2002c).

 The numerical SQGs can also be used to identify sites of potential concern with respect to
 the potential for observing adverse biological effects (Landrum 1995).  In this application,
 the concentrations of sediment-associated COPCs should be compared to the corresponding
 SQGs.   Sediments in  which none of the measured chemical concentrations exceed the
 threshold effect-type SQGs should be considered to have the lowest potential for adversely
 affecting sediment-dwelling organisms and could be considered as reference areas (Long and
 Wilson 1997). However, the potential for unmeasured substances to be present at levels of
 toxicological concern can not be dismissed without detailed information on land and water
 uses within the water body and/or the results of toxicity tests. Those sediments which have
 concentrations of one  of more  COPCs between the threshold  effect-type SQGs and the
 probable effect-type SQGs should be considered to be of moderate priority, while those with
 COPC concentrations in excess of one or more  of the probable effect-type SQGs should be
 considered to be of relatively high concern.  Once again, the magnitude and frequency of
 exceedances of the probable effect-type SQGs provide a basis for assigned relative priority
 to areas of concern with respect to contaminated sediments.

 While previous guidance has cautioned against using the SQGs as stand alone decision tools,
 the results of recent evaluations of reliability and predictive ability substantially increase the
 level of confidence that can be placed in the  SQGs.  For example, a large  database of
 matching sediment chemistry and toxicity data has been compiled to support an evaluation
 of the predictive ability of the consensus-based SQGs (USEPA 2000b). The results of this
 evaluation demonstrated that these consensus-based  SQGs provide an accurate basis for
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 classifying sediment samples as toxic or non-toxic, based on bulk sediment chemistry data
 alone. In this evaluation, mean PEC quotients (PEC-Qs; which provides a measure of overall
 sediment chemistry relative to the PECs; (USEPA 2000b; Ingersoll et al. 2001) were
 calculated and used as the primary measure of sediment chemistry.  The results of this
 assessment demonstrated that the incidence of toxicity increased consistently and markedly
 with increasing mean PEC-Qs (Table Al. 1).

 Importantly,  analysis of the underlying data supported the determination of relationships
 between mean PEC-Qs and the incidence of toxicity, such that the probability of observing
 toxicity in any sediment sample can be predicted based on the measured concentrations of
 trace metals, PAHs, and PCBs. Using these relationships, it was determined that a 50%
 probability of observing acute  and chronic toxicity to the amphipods,  Hyalella azteca,
 occurred at mean PEC-Qs of 3.4 and 0.63, respectively (Figure 2).  Therefore, the probable
 effect-type SQGs can also be used directly to support certain sediment management
 decisions, at relatively small sites, where the costs of further investigations could approach
 the costs of implementing the remedial measures.  More costly decisions should be made
 using multiple lines of evidence to assess sediment quality conditions, however (Wenning
 and Ingersoll 2002).

 Importantly,  numerical  SQGs provide consistent tools for evaluating spatial patterns in
 chemical contamination.  More specifically, the SQGs can be used to compare and rank
 sediment quality conditions among basins, waterways, or regions (Long and MacDonald
 1998). If a stratified random sampling design is used in the monitoring program, then the
 SQGs provide a basis for calculating the spatial extent of potentially toxic sediments.  In the
 areas of concern,  further investigations would typically be  implemented  to  identify
 contaminant  sources, assess the areal extent and severity of sediment toxicity, evaluate the
 potential for bioaccumulation, and/or determine the need for source control measures or other
 remedial measures. The SQGs in combination with sediment chemistry data (Chapter 2 of
 Volume III),  sediment toxicity tests (Chapter 3 of Volume HI), benthic invertebrate surveys
 (Chapter 4 of Volume III), bioaccumulation assessments (Chapter 5 of Volume HI), and fish
 health and fish community assessments (Chapter 6 of Volume ID)  can  also be used to
 evaluate the success of regulatory actions that are implemented at the site.

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A 1.3 Support for Analysis of Dredged Material Disposal Options

       In many waterways, navigational dredging is required to maintain and enhance deep-water
       harbors and shipping channels.  However, questions about the most appropriate means of
       disposing such dredged materials invariably arise during the planning and implementation
       of such dredging programs. In the United States, decisions regarding the disposal of dredged
       materials in freshwater ecosystems are guided by the tiered evaluation process described in
       the Inland Testing Manual (USEPA and USAGE 1998b).  Similar guidance has been
       developed in Canada to assist those involved in navigational dredging and other dredging
       programs (Porebski 1999).  As the Canadian system relies, to a large extent, on SQGs, it
       provides useful information on the potential applications of numerical SQGs in dredged
       material assessments.

       In Canada, a tiered testing approach has been established to inform decisions regarding the
       disposal of dredged materials.  Using this  approach, sediments are considered to be
       acceptable for open water disposal  (for suitable materials in compliance with permit
       conditions)  or beneficial use (e.g., fill, beach nourishment) if the concentrations of all
       measured COPCs are below screening levels (i.e., threshold effect-type SQGs; TELs). In
       contrast, sediments are considered to have a high potential for adverse biological effects
       when the concentrations of one or more COPCs exceed rejection levels (i.e., probable effect-
       type SQGs; PELs). Such sediments are considered to be unsuitable for open water disposal
       or for beneficial use (L. Porebski.   Environment Canada.  Ottawa, Ontario.  Personal
       communication).

       This tiered approach recognizes that there is a higher level of uncertainty when contaminant
       COPCs fall between the two guideline levels (i.e., screening and rejection levels). For this
       reason, sediments with intermediate concentrations of COPCs  should undergo biological
       testing to evaluate their suitability for open water disposal.  The biological testing includes
       a suite of toxicity tests.  The applicability of this type of tiered approach is supported by the
       results of several studies which show that there is a high probability of correctly classifying
       sediment samples as toxic and not toxic using the SQGs (MacDonald et al. 1996; Long et
       al.  1998a; 1998b; MacDonald et al. 2000a; 2000b; USEPA 2000b; Ingersoll et al. 2001).

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A 1.4  Ecological Risk Assessment
       Risk assessment is the process of determining the likelihood that adverse effects will occur
       to ecological receptors in association with exposure to environmental contamination or other
       hazards.  Ecological  risk assessment is an evolving process that is designed to  provide
       science-based guidance for managing environmental quality, particularly at contaminated
       sites. Until recently, appropriate scientific information was not available for assessing the
       ecological risks that were associated with contaminated sediments.  However, a panel of
       environmental chemists and toxicologists recently concluded that there is sufficient certainty
       associated with SQGs to recommend their use in ecological risk assessments (Ingersoll et al.
       1997; Wenning and Ingersoll 2002).

       The SQGs contribute directly to several stages of the ecological risk assessment process,
       including problem formulation, effects assessment, and risk characterization (MacDonald
       et al. 2002c). During problem formulation, background information  and Phase I sampling
       data are used to identify the problem and define the issues that need to be addressed at sites
       with contaminated sediments (Chapman et al. 1997).  At the problem formulation stage,
       SQGs can be used in conjunction with existing sediment chemistry data to identify  the
       chemicals and areas of potential concern with respect to sediment contamination (Long and
       MacDonald  1998).  In turn, this information can be used to scope out the nature and extent
       of the problem and to identify probable sources of sediment contamination at the  site. In
       addition, the SQGs provide a consistent basis for identifying appropriate reference areas that
       can be  used in subsequent assessments of the  site with contaminated sediments (Menzie
       1997).  Furthermore, the data underlying the SQGs provide a scientific basis for identifying
       appropriate  assessment endpoints  (i.e., receptors  and function to be  protected) and
       measurement endpoints (i.e., metrics for the assessment endpoints) that can be  used at
       subsequent stages of the assessment (MacDonald et al. 2002c).

       Numerical SQGs also represent effective tools that can be used to  assess the effects of
       sediment-associated COPCs (i.e., during the effects assessment of an  ecological risk
       assessment). The goal of the  effects assessment is to provide information on the toxicity or
       other effects that are likely to occur in response to exposure to contaminated sediments. In
       this application, the SQGs provide an effective basis for classifying sediments as toxic or not
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 toxic when used in conjunction with sediment chemistry data (MacDonald et al.  1996;
 USEPA 1996; MacDonald et al. 2000b; USEPA 2000b; Ingersoll et al. 2001; 2002). The
 applicability of the SQGs in effects assessments is increased when used in conjunction with
 other tools that facilitate  determinations of background concentrations of contaminants,
 sediment toxicity,  bioaccumulation, and effects on in situ benthic macroinvertebrates
 (Chapman etal. 1997; Chapter 7 of Volume HI). Matching sediment chemistry and toxicity
 from the site under investigation can be used to evaluate the predictive ability of the SQGs
 (MacDonald etal. 2002c).

 The primary purpose of the risk characterization stage of an ecological risk assessment is to
 estimate the nature and extent of the ecological risks at a site with contaminated sediments
 and to evaluate the level of uncertainty associated with that estimate (Chapman et al. 1997).
 The SQGs are  particularly useful at this  stage of the process because they provide  a
 quantitative basis for evaluating the potential for observing adverse effects in contaminated
 sediments,  for  determining the  spatial  extent of unacceptable levels  of sediment
 contamination (i.e., sediments that exceed  prescribed limits of risk to sediment-dwelling
 organisms), and for estimating the uncertainty in the risk determinations (i.e., the potential
 for Type I and Type II errors).  Importantly, calculation of the frequency of exceedance of
 the probable effect-type SQGs  and mean SQG quotients for individual  sediment samples
 enables risk assessors to estimate the probability that contaminated sediments will be toxic
 to sediment-dwelling organisms (Long etal. 1998a; 1998b; Field etal.  1999; 2002; USEPA
 2000b; MacDonald et al. 2002a; 2002b; 2002c). These procedures facilitate determination
 of the cumulative effects  of COPCs arising from multiple sources (i.e., in addition to the
 contaminated site) and evaluation of the potential for  off-site  impacts when  appropriate
 sediment chemistry data are available. The uncertainty associated with the application of the
 guidelines at this stage of the ecological risk assessment can be effectively reduced by using
 the sediment chemistry data and SQGs in conjunction with other measurement endpoints,
 such as results of toxicity tests and benthic invertebrate community assessments. Uncertainty
 associated with establishing cause and effect relationships between SQGs  and observed
 toxicity can be reduced by conducting spiked-sediment exposures and TIE procedures on
 sediment samples (Ingersoll et al. 1997).
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A1.5 Development of Sediment Quality Remediation Objectives

       Sediment quality remediation objectives (SQROs) are  an essential component of the
       contaminated sediment remediation process because SQROs can help to establish target
       clean-up levels for a site, as outline in Crane etal. (2002). Sediment quality issues are rarely
       entirely the responsibility of one agency or one level of government. For this reason, it may
       be necessary to establish agreements between various levels of government to define their
       respective responsibilities with respect to the prevention, assessment, and remediation of
       sediment contamination. Multi-jurisdictional agreements may include accords on a number
       of issues; however, establishment of site-specific SQROs is particularly important because
       they provide a common yardstick against which the success of a range of sediment
       management initiatives can be measured (MacDonald and Macfarlane 1999; Ingersoll and
       MacDonald 1999; MacDonald and Ingersoll 2000).

       Crane et al.  (2002) suggests numerical SQGs could be used in several ways to support the
       derivation of SQROs (i.e., clean-up targets).  Specifically, SQGs are useful because they
       provide a means of establishing SQROs that fulfill the narrative use protection obj ectives for
       the site (i.e., sediment management objectives). For example, SQROs  could be set well
       below chronic effects thresholds if the site management goal is to provide a high level of
       protection for sediment-dwelling organisms (e.g., meanPEC-Q of 0.1; Ingersoll etal. 2001).
       Alternatively, the SQROs could be set at chronic effects thresholds if the goal is to provide
       a moderate level of protection (e.g., meanPEC-Q of 0.63; Ingersoll etal. 2001). The SQROs
       could be set at  acute effects thresholds if the immediate goal for the site is to reduce the
       potential for acute toxicity and permit natural recovery processes to further reduce risks to
       sediment-dwelling organisms (i.e., mean PEC-Q of 3.4; Ingersoll et al. 2001). In addition,
       the SQGs and associated evaluations of predictive ability provide information that may be
       used to evaluate the costs and benefits associated with various remediation options. Costs-
       benefit analyses can be further supported by the results of predictive ability analyses, which
       provide a means  of determining the probability of observing adverse effects at various
       concentrations of sediment-associated contaminants (Field et al.  1999; MacDonald et al.
       2000b; Ingersoll et al.  2001).  Lake-wide management plans, TMDLs, the potential for
       bioaccumulation, the possibility of phototoxicity occurring, and other factors should also be
       considered in the development of SQROs.
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 It is important to note that numerical SQGs should not be regarded as blanket values for
 regional sediment quality. Variations in environmental conditions among sites could affect
 sediment quality in different ways and, hence, necessitate the modification of the guidelines
 to reflect local conditions (Wenning and Ingersoll 2002).   MacDonald and Sobolewski
 (1993) provided interim guidance on the development of site-specific SQROs. In addition,
 the results of sediment quality triad investigations at the site under investigation can be used
 to evaluate the applicability of numerical SQGs and to refine these SQGs to make them more
 directly applicable to the site, if necessary. MacDonald and Ingersoll (2000) and MacDonald
 et al. (2002a; 2002b) provided detailed information on the design and implementation of
 triad investigations for assessing the predictive ability of SQGs (see also Chapter 7 of
 Volume III).

 Importantly, the weight-of-evidence generated should be proportional  to the weight of the
 decision in the management of contaminated sediments. At small and uncomplicated sites,
 the costs associated with detailed site investigations are likely to exceed the costs associated
 with the removal and disposal of contaminated sediments. In these cases, SQGs represent
 cost-effective tools for establishing clean-up targets and developing remedial action plans
 (Wenning and Ingersoll 2002).  It should be noted that USEPA does not advocate the use of
 SQGs to establish clean-up targets without first verifying their applicability to the site under
 investigation.   At larger,  more  complicated sites, it  is  prudent  to conduct further
 investigations when preliminary screening indicate that contaminated sediments are present.
 In such  cases, the  application of toxicity testing, benthic macroinvertebrate community
 assessments,  and other tools provide a means of confirming the severity and extent of
 degraded sediment quality conditions (Wenning and Ingersoll 2002).  Application of TIE
 procedures and/or sediment spiking studies provides a basis of confirming the identity of the
 substances that are causing or substantially-contributing to sediment toxicity (Ingersoll et al.
 1997). In this way, it might be possible to design remediation action plans (RAPs) that are
 most likely to achieve the desired outcomes at the site (i.e., restoration of beneficial uses).
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Appendix 2.  Methods for Determining Background Levels
                   of Sediment-Associated Contaminants
A2.0 Introduction

       Sediment chemistry data is essential for evaluating sediment quality conditions. However,
       interpretation of environmental data is  made difficult by the fact that the measured
       concentrations of sediment-associated contaminants can be elevated, even in the absence of
       point source contaminant releases.  In some cases, for example, the combination of ambient
       sediment mineralogy and grain size can result in elevated concentrations of certain metals
       (Schropp et al. 1990; Loring 1991).  In addition, the levels of PAHs and other petroleum
       hydrocarbons can be elevated in the vicinity of naturally-occurring of oil seeps (MacDonald
       1994c). Likewise, natural phenomena such as volcanoes and forest fires can release PCDDs
       and PCDFs into the atmosphere and, ultimately, result in the contamination of sediments
       (MacDonald  1993). Finally, anthropogenic activities (such as pesticide application or
       disposal of persistent organic substances) conducted in areas far-removed from the site under
       consideration can result in elevated levels of PCBs, organochlorine pesticides, and other
       substances in sediments (i.e., through long-range atmospheric transport and subsequent
       deposition in aquatic ecosystems (MacDonald 1995).  As such, information on contemporary
       background levels of contaminants in an area is  relevant for assessing sediment quality
       conditions and assessing and remedial options that may be proposed for a site.

       The  concentrations of trace metals in sediments  are  influenced by a variety of factors,
       including sediment mineralogy, grain size, organic content, and anthropogenic enrichment
       (Schropp and Windom 1988). This combination of factors results in metals levels that can
       vary over several orders of magnitude at uncontaminated sites  (Schropp et al. 1990).
       Therefore, it is important to consider the natural background levels of sediment-associated
       metals when conducting sediment quality assessments, particularly in regions that have rivers
       draining metal-rich geologic formations.
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       There are several procedures available for determining contemporary background levels of
       contaminants in sediments.  In general, these procedures can be grouped into two main
       categories, including:

          •  Reference sediment approach; and,

          •  Reference element approach.


       Overviews of these methods for determining contemporary background levels of sediment-
       associated contaminants are provided in the following sections of this appendix.
A2.1 Reference  Sediment Approach

       The reference sediment approach involves the determination of regional background levels
       of metals and/or organic contaminants in the area or region under consideration. Data on
       regional background levels  is important because it provides the information needed to
       establish contemporary levels of sediment-associated contaminants (i.e., which includes the
       contribution of chemicals that are associated with human activities, both regionally and at
       larger geographic scales).  One such procedure involves the collection and analysis of
       surficial sediments from a number of uncontaminated reference sites (i.e., locations that are
       not affected by known localized contaminant sources) to establish contemporary background
       concentrations of trace metals or other substances on a regional basis (Persaud et al. 1989).
       In this case, the  95% confidence interval  may be used to define the normal  range of
       contaminant concentrations  for the region (Reynoldson et al. 1995).   The upper limit of
       normal levels can be determined directly from this distribution (i.e., the upper 95%
       confidence limit;  Dunn 1989). Alternatively, the mean plus four standard deviations (i.e.,
       the upper 99% confidence limit) can be used to estimate the upper limit of contemporary
       background concentrations for the region (IDEM 1992; Adams 1995).

       The reference sediment approach can also be used to estimate historic concentrations of trace
       metals or organic contaminants on a site-specific  basis. In this case, sediment coring
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       procedures are used to obtain samples of site sediment from various depths. It is important
       to collect these cores from fine-grain sediments that have not been disturbed by physical
       mixing or bioturbation.  Chemical analysis of the sub-sections, in conjunction with
       radiometric dating methods (i.e., 137Cs, 210Pb, or 228Th dating; Valette-Silver 1993; Mudroch
       and Azcue 1995), provides information for determining how the concentrations of each
       substance have varied over time.  In this way, it is possible to establish the levels of trace
       metals that correspond to relevant dates in the development of the watershed (i.e., back to
       the  early 1800s).  It may  be difficult to  determine pre-industrial levels  of metals if
       sedimentation rates are high, however (Alexander 1993). Therefore, use of a large-scale
       regional data base  may help provide  metal concentrations  as a background reference.
       Statistical methods can be applied to the data that are generated from multiple cores to
       establish the normal range of background levels for the site under investigation (Reynoldson
       et al.  1995).  The upper limit of background can then be established directly from these
       summary statistics.
A2.2 Reference Element Approach
       The reference element approach was developed to provide a basis for assessing metal
       contamination in sediments (Loring 1991; Schropp and Windom 1988; Schropp etal. 1990;
       Schiff and Weisberg 1996). This procedure relies on normalization of metal concentrations
       to  a reference element.   Normalization of metal  concentrations to  concentrations of
       aluminum in estuarine sediments provided the most useful method of comparing metal levels
       on a regional basis in Florida estuaries. However, normalization using lithium, iron, or other
       reference elements has been used in other estuarine regions  (Loring  1991; Schiff and
       Weisberg 1996).  Recently, Carvalho and Schropp (2001) demonstrated that normalization
       of metal concentrations to the concentrations of aluminum also provides an effective basis
       for evaluating metal enrichment in freshwater sediments.

       Development of the metals interpretive tool is a relatively straight forward process. Briefly,
       data on sediment metal concentrations are collected from roughly 100 sites chosen for being
       remote from known or potential sources of metals contamination. Total metal concentrations
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 are determined in each of these samples. Simple linear regressions of the concentrations of
 each of seven metals to aluminum concentrations are performed on log-transformed data and
 95% prediction limits are calculated.  The regression lines and prediction limits are then
 plotted.  These plots then form the basis for interpreting data on the concentrations of metals
 in sediments, such that anthropogenic enrichment of metal levels would be suspected at sites
 with metals concentrations exceeding the upper 95% prediction limit (for one or  more
 substances). The application of this procedure using data from various estuarine areas (e.g.,
 Tampa  Bay, Schropp  et al. 1989; Louisiana, Pardue et al.  1992) has  supported the
 effectiveness and utility of this interpretive tool.  A comparable tool for assessing metal
 enrichment in freshwater sediments has been developed for the State of Florida (Figure A2-1;
 Carvalho and Schropp 2001).
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                            APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 186
Appendix 3. Approaches    to    the    Development of
                  Numerical Sediment Quality  Guidelines
A3.0 Introduction

      Numerical SQGs  (including ESBs, sediment quality objectives, and sediment quality
      standards) have been developed by various jurisdictions in North  America  for both
      freshwater and marine ecosystems. The SQGs that are currently being used  in North
      America have been developed using a variety of approaches, including both empirical and
      theoretical approaches.  Both empirical and theoretical approaches were considered to
      support the derivation numerical SQGs for the protection of sediment-dwelling organisms,
      including:

            Screening Level Concentration Approach (SLCA);

         •  Effects Range Approach (ERA);

         •  Effects Level Approach (ELA);

         •  Apparent Effects Threshold Approach (AETA);

         •  Equilibrium Partitioning Approach (EqPA);

         •  Logistic Regression Modeling Approach (LRMA); and,

            Consensus Approach (CA).


      The tissue residue approach represents the primary method for deriving numerical SQGs for
      the protection of wildlife and human health (i.e., for substances that bioaccumulate in the
      food web). The following sections of this report provide brief descriptions of each of these
      approaches.
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A3.1 Screening Level Concentration Approach

       The screening level concentration approach (SLCA) is a biological effects-based approach
       that is applicable to the development of SQGs for the protection of benthic organisms. This
       approach utilizes matching biological and  chemistry data collected in field surveys to
       calculate a screening level concentration (SLC; Neff et al. 1986). The SLC is an estimate
       of the highest concentration of a contaminant that  can be tolerated by  a pre-defined
       proportion of benthic infaunal species.

       The SLC is determined through the use of a database that contains information on the
       concentrations of specific contaminants in sediments and on the co-occurrence of benthic
       organisms in the same sediments. For each benthic organism for which adequate data are
       available,  a species screening level concentration  (SSLC) is calculated.   The SSLC is
       determined by plotting the frequency distribution of the contaminant concentrations over all
       of the sites at which the species  occurs (information from at least ten sites is required to
       calculate a SSLC).  The 90th percentile of this distribution is taken as the SSLC for the
       species being investigated.  The SSLCs for all of the species for which adequate data are
       available are then compiled as a frequency distribution to determine the concentration that
       can be  tolerated by a specific proportion of the species (i.e., the 5th  percentile of the
       distribution would provide an SLC that should be tolerated by 95% of the species).  This
       concentration is termed the screening level concentration of the contaminant.

       A number of jurisdictions have used  the SLCA to derive numerical SQGs.  In the St.
       Lawrence  River, two SQGs were developed for five groups of PCBs using the  SLCA,
       including a minimal effect threshold (MET) and a toxic effect threshold (TET; EC and
       MENVIQ  1992).  The MET was calculated as the 15th percentile of the SSLCs, while the
       TET was calculated as the 90th percentile of the SSLC distribution for each substance.
       Therefore, the MET and TET are considered to provide protection for 85% and 10% of the
       species represented in the database, respectively. Similarly, Environment Ontario developed
       a lowest effect level (LEL) and severe effect level (SEL) using this approach (Persaud et al.
       1993). Neff et al. (1986) also developed a screening level concentration (SLC) for tPCBs
       primarily using data from the Great Lakes.

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A3.2 Effects Range Approach
       The effects range approach (ERA) to the derivation of SQGs was developed to provide
       informal tools for assessing the potential for various contaminants tested in the National
       Status and Trends Program (NSTP) to be associated with adverse effects on sediment-
       dwelling organisms (Long and Morgan  1991).  As a first step, a database was compiled
       which contained information on the effects of sediment-associated contaminants, including
       data from spiked-sediment toxicity tests, matching sediment chemistry and biological effects
       data from field studies in the United States, and SQGs that were derived using various
       approaches. All of the information in the database was weighted equally, regardless of the
       method that was used to develop it. The objective of this initiative was to identify informal
       guidelines which could be used to evaluate sediment chemistry data collected nationwide
       under the NSTP.

       Candidate data sets from field studies were evaluated to determine their applicability for
       incorporation into the database.  This evaluation was designed to determine the overall
       applicability of the data set, the methods that were used, the end-points that were measured,
       and the degree of concordance between the chemical and biological data.  The data which
       met the evaluation criteria were incorporated into the database (Long and Morgan 1991;
       Long etal. 1995).

       The database that was compiled included several types of information from each  study.
       Individual entries consisted of the concentration of the contaminant, the location of the study,
       the species tested and endpoint measured, and an indication  of whether or not there was
       concordance between the observed effect and the concentrations of a specific chemical (i.e.,
       no effect, no or small gradient, no concordance, or a "hit", which indicated that an effect was
       measured in association with elevated  sediment chemistry).  Data from non-toxic or
       unaffected samples were assumed to represent background conditions. Data which showed
       no concordance between chemical and biological variables were included in the database,
       but were not used to calculate the SQGs. The data for which a biological effect was observed
       in association with elevated chemical concentrations (i.e., hits) were sorted in ascending
       order of concentration and the 10th and 50th percentile concentrations for each compound
       were determined.  The effects range-low (ERL; 10th percentile value) was considered to
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                               APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 189
       represent a lower threshold value, below which adverse effects on sensitive life stages and/or
       species occurred infrequently.  The effects range-median (ERM; 50th percentile value) was
       considered  to represent a  second threshold value, above which adverse effects were
       frequently observed.  These two parameters, ERL and ERM, were then used as informal
       SQGs (Long and Morgan 1991; Long et al. 1995). USEPA (1996) used a similar approach
       to derive ERLs  (15th percentile of the effects data  set) and ERMs (50th percentile of the
       effects data set) for assessing sediments from various freshwater locations.   Similarly,
       MacDonald (1997) applied the effects range approach to regionally-collected field data to
       derive site-specific sediment effect concentrations  for PCBs and DDTs in the Southern
       California Bight.
A3.3 Effects Level Approach

       The effects level approach (ELA) is closely related to the effects range approach described
       above. However, the ELA is supported by an expanded version of the database that was used
       to derive the effects levels (Long  and Morgan  1991).  The expanded  database contains
       matching sediment chemistry and biological effects data from spiked-sediment toxicity tests
       and from field studies conducted throughout North America (including both effects and no
       effects data). The expanded database also contains SQGs derived using various approaches.
       The information contained in the expanded database was evaluated and classified in the same
       manner that was used to compile the original NSTP database.

       In the ELA, the underlying information in the database was used to derive two types of
       SQGs, including threshold effect levels (TELs) and probable effect levels (PELs). The TEL,
       which is calculated as the geometric mean of the 15th percentile of the effects data set and the
       50th percentile of the no effects data set, represents the chemical concentration below which
       adverse effects occurred only infrequently. The PEL represents a second threshold value,
       above which adverse effects were frequently observed.  The PEL is calculated as the
       geometric mean of the 50th percentile of the effects data set and the 85th percentile of the no
       effects data set. These arithmetic procedures have been applied to the expanded database to
       derive numerical SQGs (i.e., TELs  and PELs) for Florida coastal waters  (MacDonald et al.
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                              APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 190
       1996), United States freshwater systems (USEPA  1996), and Canadian freshwater and
       marine systems (Smith etal 1996; CCME 1999).
A3.4 Apparent Effects Threshold Approach

      The apparent effects threshold approach (AETA) to the development of SQGs was developed
      for use in the Puget Sound area of Washington State (Tetra Tech Inc. 1986).  The AETA is
      based  on  empirically-defined  relationships between  measured  concentrations  of a
      contaminant in sediments and observed biological effects.  This approach is intended to
      define the concentration of a contaminant in sediment above which significant (p < 0.05)
      biological effects are observed.  These biological effects include, but are not limited to,
      toxicity to benthic and/or water column species (as measured using sediment toxicity tests),
      changes in the abundance of various benthic species, and changes in benthic community
      structure. In Puget Sound, for example, four AET values have been generated, including
      AETs for Microtox, oyster larvae, benthic community, and amphipods. The AET values are
      based on dry weight-normalized contaminant concentrations  for metals and  either  dry
      weight- or TOC-normalized concentrations for organic substances (Barrick et al.  1988;
      Washington Department of Ecology 1990). The state of Washington has used the various
      AET values to establish sediment quality standards and minimum clean-up levels for COCs
      in the state.

      Cubbage etal. (1997) refined this approach to support the development of probable AETs
      (PAETs) using matching sediment chemistry and toxicity data for freshwater sediments from
      the state of Washington. USEPA (1996) utilized a similar approach to develop freshwater
      AETs (termed no effect concentrations or NECs in that study) using data from various
      freshwater locations.
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                               APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 191
A3.5 Equilibrium Partitioning Approach
       The water-sediment equilibrium partitioning approach (EqPA) has been one of the most
       studied and evaluated approaches for developing SQGs (sometimes termed ESBs) for non-
       ionic organic chemicals and metals (Pavlou and Weston 1983; Bolton et al. 1985; Kadeg
       etal. 1986; Pavloul987; Di Toro era/. 1991; Ankley etal. 1996; Hansene^a/. 1996). This
       approach is based on the premise that the distribution of contaminants among different
       compartments in the sediment matrix (i.e., sediment solids and pore water) is predictable
       based on their physical and chemical properties, assuming that continuous equilibrium
       exchange between sediment and pore water occurs.  This approach has been supported by
       the results of spiked-sediment toxicity tests, which indicate that positive correlations exist
       between the biological effects observed and the concentrations of contaminants measured in
       the pore water (Di Toro et al. 1991; Ankley et al. 1996; Berry et al. 1996; Hansen et al.
       1996).  A primary strength of the EqPA approach is that the bioavailability of individual
       classes of compounds (i.e., metals or non-ionic organic compounds) can be addressed.

       In the EqPA, water quality criteria developed for the protection  of freshwater  or marine
       organisms are used to  support the SQGs derivation process. As such,  the water quality
       criteria formulated for the protection of water column species are assumed to be applicable
       to benthic organisms (Di Toro et al. 1991). The ESBs are calculated using the appropriate
       water quality criteria (usually the final chronic values, FCVs, or equivalent values; USEPA
       1997) in conjunction with the sediment/water partition coefficients  (Kp) for the specific
       contaminants [note that other effect concentrations (e.g., an LC50 for a particular  species of
       concern) can also be used in the calculation of ESBs].  The final  chronic value  is derived
       from the species mean chronic values that have been calculated from published toxicity data
       and is intended to protect 95% of aquatic species.  The calculation procedure for non-ionic
       organic contaminants is as follows:

                                       SQG = Kp • FCV
          where:
                    SQG  = Sediment quality guideline [in jig/kg of organic carbon (OC)];
                    Kp    = Partition coefficient for the chemical (in L/kg);  and,
                    FCV   = Final Chronic Value (in |ig/L).
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       The Kp is a function of the partition coefficient for sediment organic carbon (Koc) of the
       substance under consideration and the amount of organic carbon in the sediment under
       investigation (foc;  where Kp = Koc • foc; Di Toro et al.  1991).  The Koc  for non-ionic
       substances can be calculated from its Kow (Di Toro et al. 1991).  Procedures for evaluating
       the potential for sediment toxicity due to the presence of metals have also been developed
       (Ankley et al.  1996).   These procedures  rely on the determination of AVS and SEM
       concentrations.  Samples in which the molar concentrations of AVS equal  or exceed the
       molar concentrations of five divalent metals (Cd, Cu, Pb, Ni, Zn) are unlikely to be toxic due
       to metals.  In contrast, samples with SEM-AVS >1 could be toxic due to metals (Ankley et
       al. 1996). Based on the results of more recent analyses,  SEM-AVS >5 may be a better
       predictor of toxicity due to the presence of divalent cationic metals.
A3.6 Logistic Regression Modeling Approach
       In the logistic regression modeling approach (LRMA), numerical SQGs are derived from the
       results of field studies of sediment quality conditions in marine and estuarine habitats. The
       first step in this process involves the collection, evaluation, and compilations of matching
       sediment chemistry and toxicity data from a wide variety of sites in North America (Field et
       al. 1999; 2001). Next, the information that were compiled in the database were retrieved on
       a substance-by-substance basis, with the data from individual sediment samples sorted in
       order of ascending concentration.  For each sediment sample, the ascending data table was
       used to provide information on the concentration of contaminant under consideration (on
       either a dry weight- or organic carbon-normalized basis) and the toxicity test results (i.e.,
       toxic or not toxic) for each toxicity test  endpoint  (e.g.,  10-day survival  of marine
       amphipods).

       In the next step of the process, the data contained in the ascending data tables were screened
       to minimize the potential for including samples in which the selected contaminant did not
       contribute substantially to the observed toxicity. In this analysis, the chemical concentration
       in each toxic sample was compared to the mean concentration in the non-toxic samples from
       the same study and geographic area.  The toxic samples with concentrations of the selected
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                          APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 193
 contaminant that were less than or equal to the average concentration of that chemical in the
 non-toxic samples were not used to develop the models for each COPC (i.e., it was highly
 unlikely that the contaminant substantially contributed to sediment toxicity in such samples).

 In the final step of the analysis, the screened data were used to develop logistic regression
 models, which express  the  relationship between  the  concentration of  the  selected
 contaminant and the probability of observing toxicity.  In its simplest form, the logistic
 model can be described using the following equation:

                                _ eBO+Bl(x) -H n + gBO+Bl(x)\
    where:
                p    =   probability of observing a toxic effect;
                BO   =   intercept parameter;
                Bl   =   slope parameter; and,
                x    =   concentration or log  concentration of the chemical.

 Using databases consisting of the results of 10-day amphipod toxicity tests, Field et al.
 (1999; 2002) derived logistic regression models for several chemical substances to illustrate
 the methodology.  More specifically, these studies calculated T10, T20, T50, T80, or T90
 values for several metals, PAHs, and total PCBs.  These values represent  the  chemical
 concentrations that correspond to a 10%,  20%, 50%, 80%, or 90% probability of observing
 sediment toxicity. In addition to supporting the derivation of specific T-values, this method
 can be used to determine the concentration  of  a contaminant that corresponds to any
 probability of observing toxicity. Therefore, a sediment manager can identify  an acceptable
 probability of  observing sediment toxicity  at  a  site (e.g.,  25%) and  determine  the
 corresponding chemical concentrations (e.g., T25  value).  The calculated value can then be
 used as the SQG for the site. This procedure is currently being used to evaluate data as part
 of a second report to Congress on sediment quality (an update to USEPA 1997).
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                               APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 194
A3.7 Consensus Approach
       In the consensus approach (CA), consensus-based SQGs were derived from the existing
       SQGs that  have  been published for the protection of sediment-dwelling organisms
       (MacDonald et al. 2000a; 2000b). Derivation of numerical SQGs using the CA involved as
       four  stepped process.  In a  first step, the SQGs  that have been  derived by various
       investigators for assessing the quality of freshwater sediments were collected and collated.
       Next, the SQGs obtained from all sources were evaluated to determine their applicability to
       the derivation of consensus-based SQGs.  The  selection criteria that were applied  are
       intended to  evaluate the transparency of the derivation methods, the  degree to which  the
       SQGs are effects-based, and the uniqueness of the SQGs.

       The effects-based SQGs that meet these selection criteria were then grouped in MacDonald
       et al.  (2000a; 2000b) to facilitate the derivation of consensus-based SQGs (Swartz  1999).
       Specifically, the SQGs for the protection of sediment-dwelling organisms were grouped into
       two categories according to their original  narrative intent, including TECs  and probable
       effect concentrations  (PECs).   The TECs  were  intended to  identify  contaminant
       concentrations below which harmful effects on sediment-dwelling organisms were unlikely
       to be  observed. Examples of TEC-type SQGs include threshold effect levels (TELs; Smith
       et al.  1996; USEP A 1996), effect range low values (ERLs; Long and Morgan 1991; USEP A
       1996), lowest effect levels (LELs; Persaud etal.  1993), and chronic equilibrium partitioning
       thresholds (USEPA 1997).  The PECs were intended to identify contaminant concentrations
       above which harmful effects on sediment-dwelling organisms were likely to  be frequently
       or always observed (MacDonald et al. 1996; Swartz 1999).  Examples of PEC-type SQGs
       include probable effect levels (PELs; Smith etal. 1996; USEPA 1996), effect range median
       values (ERMs; Long and Morgan 1991; USEPA 1996); and severe effect levels (Persaud et
       al. 1993).

       Following classification of the published SQGs, consensus-based TECs were  calculated by
       determining the geometric mean of the SQGs that were included in this category. Likewise,
       consensus-based PECs were calculated by determining the geometric mean of the PEC-type
       values. The geometric mean, rather than the arithmetic mean, was calculated because it
       provided an  estimate of central tendency that was not unduly affected by outliers and because
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                               APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 195
       the distributions of the SQGs were not known.  Consensus-based TECs or PECs were
       calculated only if three of more published SQGs are available for a chemical substance or
       group of substances (MacDonald etal. 2000a; 2000b).

       The CA has been used to derive numerical SQGs for a variety of chemical substances and
       media types.  For example, Swartz (1999) derived consensus-based SQGs for PAHs in
       marine ecosystems.  More recently, MacDonald et al. (2000a) derived SQGs for total PCBs
       in freshwater and marine sediments.  Ingersoll and MacDonald (1999) and MacDonald et al.
       (2000a; 2000b) have also developed consensus-based SQGs for metals, PAHs, PCBs, and
       several pesticides in freshwater sediments. USEPA (2000b) and Ingersoll etal. (2001) used
       consensus-based SQGs to evaluate the incidence of toxicity in a national freshwater database.
       As the term implies, consensus-based SQGs are intended to reflect the agreement among the
       various SQGs by providing an estimate of their central tendency.  Consensus-based SQGs
       are,  therefore, considered to provided a unifying synthesis of the existing SQGs, reflect
       causal rather than correlative effects, and account for the effects of contaminant mixtures in
       sediment (Swartz 1999; Di Toro and McGrath 2000; MacDonald et al. 2000a; 2000b).
A3.8 Tissue Residue Approach
       The tissue residue approach (TRA; which is also known as the biota-water-sediment EqPA)
       is based on the fact that sediments represent important  sources of contaminants that
       bioaccumulate in the tissues of aquatic organisms and are transferred into aquatic food webs.
       For this reason, it is necessary to assure that the concentrations of sediment-associated
       contaminants remain below the levels that are associated with the accumulation of such
       contaminants to harmful levels in sediment-dwelling organisms and other elements of the
       food web.  Therefore, application of the TRA involves the establishment of safe sediment
       concentrations for individual chemicals or classes of chemicals by determining the chemical
       concentrations in sediments that are predicted to result in acceptable tissue residues (i.e., in
       fish and shellfish tissues that are consumed by piscivorus wildlife).
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                         APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 196
 Derivation of numerical SQGs using the TRA involves several steps. As a first step, the
 contaminants for which SQGs are to be derived are selected based on their potential to
 accumulate in aquatic food  webs.   Next,  numerical  TRGs are  identified  for these
 contaminants. Three types of TRGs may be used to derive the SQGs, including:

    •   Critical body burdens in  sediment-dwelling organisms,  which define  the
        threshold levels of tissue-associated contaminants relative to adverse effects on
        benthic species (e.g., Jarvinen and Ankley 1999);

    •   Tissue residue guidelines for the protection of aquatic-dependent wildlife, which
        define tolerable levels of contaminants in fish and aquatic invertebrates that are
        consumed by avian and mammalian receptors (e.g., Newell et al. 1987); and,

        Tissue residue guidelines for the  protection  of human health, which define
        tolerable levels of contaminants in fish and shellfish that  are consumed by
        humans (e.g., Federal Drug Administration Action Levels).


 Following the selection of TRGs, BSAFs are determined each of the substances of concern.
 Such BSAFs can be determined from the results of bioaccumulation assessments, from
 matching sediment chemistry and tissue residue data collected in the field, and/or from the
 results of bioaccumulation models.  Such BSAFs must be relevant to the species under
 consideration (i.e., laboratory-derived BSAFs for polychaetes should not be used directly to
 estimate BSAFs in fish).  Numerical SQGs are subsequently derived using the equation:

                                SQG=TRG-BSAF

 This approach has been used on several occasions to develop  SQGs for the protection of
 human health, most frequently for DDTs, mercury, and PCBs. In addition, SQGs for 2,3,7,8
 tetrachlorodibenzo-p-dioxin (T4CDD) have been established for Lake Ontario on the basis
 offish tissue residues (Endicott et al. 1989; Cook et al. 1989).  The applicability of this
 approach to the derivation of SQGs is supported by data which demonstrate that declines in
 DDT residues in fish and birds (since its use was banned) are strongly correlated with
 declining concentrations of this substance in surficial sediments in the Great Lakes and

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                          APPENDIX 3 -APPROACHES TO THE DEVELOPMENT OF NUMERICAL SQGs - PAGE 197
 Southern California Bight.  As such, this approach is a logical companion for the EqPA and
 the other approaches that were described previously. However, uncertainty in the selection
 of critical body burdens in sediment-dwelling organisms limits the applicability of this
 approach for deriving SQGs for the protection of benthic invertebrate species.
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                                    APPENDIX 4 - CRITERIA FOR EVALUATING CANDIDATE DATA SETS - PAGE 198
Appendix 4.  Criteria for Evaluating Candidate Data Sets
A4.0 Introduction

      In recent years, the Great Lakes National Program Office (USEP A), United States Geological
      Survey, National Oceanic and Administration, Minnesota Pollution Control Agency, Florida
      Department of Environmental Protection, British Columbia Ministry of Water, Air and Land
      Protection, MacDonald Environmental Sciences Ltd., and EVS Consultants have been
      developing a database of matching sediment chemistry and sediment toxicity data to support
      evaluations of the predictive ability of numerical  SQGs in the Great Lakes Basin and
      elsewhere in  North America (Field et al.  1999; USEPA 2000b; Crane et al. 2000).  In
      addition, various project-specific databases have been developed to facilitate access to and
      analysis of data sets  to support natural resource damage assessment and restoration and
      ecological risk assessments at sites with contaminated sediments (MacDonald and Ingersoll
      2000; Crane et al. 2000; MacDonald et al. 2001a; 2001b; Ingersoll et al. 2001).  The goal
      of these initiatives was to collect  and collate the highest quality data sets  for  assessing
      sediment quality conditions at contaminated sites and evaluating numerical SQGs.  To assure
      that the data used in these assessments met the associated DQOs, all of the candidate data
      sets were critically evaluated before inclusion in the database. However, the  screening
      process was also designed to be flexible to assure that professional judgement could also be
      used when necessary in the evaluation process.  In this way, it was possible to include as
      many data sets as possible and, subsequently, use them to the extent that the data quality and
      quantity dictate.

      The following criteria for evaluating candidate data sets were established in consultation with
      an ad hoc Science Advisory Group on Sediment Quality Assessment (which is comprised
      of representatives of federal, provincial, and state government agencies, consulting firms, and
      non-governmental  organizations  located throughout North America  and elsewhere
      worldwide). These criteria are reproduced here because they provide useful guidance on the
      evaluation of data that have been generated to support sediment quality assessments.  In


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                                   APPENDIX 4 - CRITERIA FOR EVALUATING CANDIDATE DATA SETS - PAGE 199
       addition, these criteria can be used to support the design of sediment sampling and analysis
       plans, and associated quality assurance project plans (see Volume II).
A4.1 Criteria for Evaluating Whole Sediment,  Pore Water, and
        Tissue Chemistry

      Data on the chemical composition of whole sediments, pore water, and biological tissues are
      of fundamental importance in assessments of sediment quality conditions.  For this reason,
      it is essential to ensure that high quality data are generated and used to support such sediment
      quality assessments.  In this respect, data from individual studies  are considered to be
      acceptable if:

          •  Samples  were  collected from any  sediment  horizon (samples representing
             surficial sediments are  most appropriate for assessing  effects on sediment-
             dwelling organisms and other receptors, while samples of sub-surface sediments
             are appropriate for assessing potential effects on sediment-dwelling organisms
             and other receptors, should these sediments become exposed; ASTM 200la;
             ASTM 200 le; USEPA 2000a);

          •  Appropriate procedures were used for collecting, handling, and storing sediments
             (e.g., ASTM 200le; 200Id; USEPA 2001) and samples of other media types;

             The concentrations of a variety of COPCs were measured in samples;

          •  Appropriate analytical methods were used to generate chemistry data.  The
             methods  that  are considered to be appropriate included USEPA  approved
             methods,  other standardized methods (e.g., ASTM methods, SW-846 methods),
             or methods that have been demonstrated to be equivalent or superior to standard
             methods;  and,

          •  Data quality objectives were  met. The criteria that are used to evaluate data
             quality included:

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                                    APPENDIX 4 - CRITERIA FOR EVALUATING CANDIDATE DATA SETS - PAGE 200
             (i)     the investigator indicated that DQOs had been met;
             (ii)    analytical  detection limits were reported and  lower than the  PECs
                    (however, detection limits < TEC are preferred);
             (iii)   accuracy and precision of the chemistry data were reported and within
                    acceptable ranges for the method;
             (iv)   sample contamination was not noted (i.e., analytes were not detected
                    at unacceptable concentrations in method blanks); and,
             (v)    the results of a detailed independent review indicated that the data
                    were acceptable and/or professional judgement indicated that the data
                    set was likely to be of sufficient quality to be used in the assessment
                    (i.e., in conjunction with  author  communications  and/or  other
                    investigations).
A4.2 Criteria for Evaluating Biological Effects Data

      Data on the effects of contaminated sediments on sediment-dwelling organisms and other
      aquatic species provide important information for evaluating the severity and extent of
      sediment contamination.  Data from individual studies are considered to be acceptable for
      this purpose if:

          •   Appropriate procedures were used for collecting, handling, and storing sediments
              (e.g., ASTM 2001c; USEPA 2000a; 2001); Sediments were not frozen before
              toxicity tests were initiated (ASTM 200la; 200le);
          •   The responses  in the negative control  and/or reference  groups were within
              accepted limits (i.e., ASTM 2001a;2001d;2001e;2001f;2001g;2001h; USEPA
              2000b);
          •   Adequate environmental conditions were maintained in the test chambers during
              toxicity testing  (i.e., ASTM 2001a; 2001e; USEPA 2000b);
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                               APPENDIX 4 - CRITERIA FOR EVALUATING CANDIDATE DATA SETS - PAGE 201
        The endpoint(s) measured were ecologically-relevant (i.e., likely to influence the
        organism's viability in the field) or indicative of ecologically-relevant endpoints;
        and,

    •   Appropriate procedures were used to conduct bioaccumulation tests (ASTM
        200 Id).

 Additional guidance is presented in USEPA (1994) and in Chapter 4 of Volume III for
 evaluating the quality of benthic community data generated as part of a sediment quality
 assessment.  These criteria include collection of replicate samples, resorting at least 10% of
 the samples, and independent checks of taxonomic identification of specimens.  Guidance
 is presented in USEPA (2000c) and in Schmitt et al. (2000) for evaluating the quality offish
 health and fish community data.
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Appendix
 Tables

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Table Al.l. Incidence of toxicity predicted in laboratory toxicity tests using mean probable effect concentration-quotients
            (PEC-Qs; USEPA 2000b).


                                                           Incidence of Toxicity (%) by Mean PEC-Q
Test Species/Duration                           <0.1              0.1 - <0.5             0.5 - <1.0             >1.0


Hyalella azteca, 10 to 14-day                       18%                 16%                 37%               54%

Hyalella azteca, 28 to 42-day                       10%                 13%                 56%               97%

Chironomus spp., 10 to 14-day                      20%                 17%                 43%               52%
                                                                                                                        Page 203

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Appendix
 Figures

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Figure A2.1. Metal/aluminum regression lines with the 95% prediction limits (from Carvalho and Schropp 2001).
        10 3	1      1000 3	
         1 :
       0.1 :
  .2   0.01 =
      0.001 :
     0.0001
          10
     1000 3
      100 =
       10 =
  3
      0.1 =
     0.01
         10
100           1000           10000
          Aluminum (ppm)
            •  Sample Data
                                                                      E
                                                                      Q_
                                                  100 :
                                                   10 :
                                                                           1 =
                                                                         0.1 =
                                                                         0.01
 100           1000          10000         100000        10
          Aluminum (ppm)
                                                  1000 3
                                                   100 :
                                                                      I
                                                                      N
                                                    1 :
                                                   0.1 :
                                                                         0.01
                                                                100000       10
                                                                    Regression Line
100           1000
          Aluminum (ppm)
        95 % Prediction Limits
10000
100           1000           10000         100000
          Aluminum (ppm)
100000
                                                                                                                                    Page 205

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Figure A2.1.  Metal/aluminum regression lines with the 95% prediction limits (from Carvalho and Schropp 2001).
    100 3	1        1000 a	
E
Q_
     10 =
      1 :
    0.1 =
   0.01 =
  0.001
       10
      10
E
Q.
Q_
     0.1
>
w   0.01
   0.001
  0.0001
        10
100
    1000
Aluminum (ppm)
10000
 100           1000
          Aluminum (ppm)
             •  Sample Data
                  10000
                                                    100;
                                                     10 :
                                                      1 =
                                                     0.1 =
           0.01
100000         10
                                                      1003
                                                                           10 =
                                                        1 :

                                                 I
                                                 E   0.1 i
                                                 ^
                                                 -o
                                                 8  0.01 J
                                                                         0.001 =
                        0.0001
              100000          10
                                                                   Regression Line
100
    1000
Aluminum (ppm)
10000
                             100           1000
                                       Aluminum (ppm)
                                   95 % Prediction Limits
                            10000
100000
                                100000
                                                                                                                                       Page 206

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Figure A2.1.  Metal/aluminum regression lines with the 95% prediction limits (from Carvalho and Schropp 2001).
   10000 3
    1000
     100
 I    10
 E
 o
 o     ,
     0.1 :
     0.01
        10
100
    1000
Aluminum (ppm)

1  Sample Data
10000
                       10000 3
                        1000 :
                        100 :
                                                                    Q_
                         10 1
                         0.1 1
                        0.01
100000
10
                                                              Regression Line
 100           1000
          Aluminum (ppm)

— 95 % Prediction Limits
10000
100000
                                                                                                                                 Page 207

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