United States
                   Environmental Protection
                   Agency	
                        Prevention, Pesticides
                        And Toxic Substances
                        (7508C)	
EPA738-F-99-010
September 1999
                    R.E.D.    FACTS
                    Bendiocarb
      Pesticide
Reregistration
     All pesticides sold or distributed in the United States must be registered by
EPA, based on scientific studies showing that they can be used without posing
unreasonable risks to people or the environment. Because of advances in scientific
knowledge, the law requires that pesticides which were  first  registered before
November 1, 1984, be reregistered to ensure that they meet today's more stringent
standards.
     In evaluating pesticides for reregistation, EPA obtains and reviews a complete
set of studies from pesticide producers, describing the human health and environmental
effects of each pesticide. To implement provisions of the Food Quality Protection Act
(FQPA) of 1996, EPA considers the special sensitivity of infants and children, as well
as aggregate exposure of the public to residues of the pesticide from all sources, and
the  cumulative effects of the pesticide and other compounds  with a common
mechanism of toxicity.  The Agency develops any mitigation measures or regulatory
controls needed to effectively reduce each pesticide's risks. EPA reregisters pesticides
that meet the safety standard of FQPA and can be used without posing unreasonable
risks to human health or the environment.
     This fact sheet serves as and explains EPA's Reregistration Eligibility Decision
(RED) for Bendiocarb (0409), which consists of a voluntary cancellation of this
pesticide. Bendiocarb was scheduled for a reregistration decision in 1999. However,
the  registrants supporting bendiocarb's registration have requested voluntary
cancellation. The public will have 30 days to comment on the voluntary cancellation
of bendiocarb when the notice of voluntary cancellation is published in the Federal
Register.  In addition, the registrants have been granted a 14 month existing stocks
provision for products used in or around the home and a 28 month existing stocks
provision for other products.
     The following information is based on the preliminary review of the existing
information on bendiocarb. As a result of the voluntary cancellation, a final review for
reregistation will not be completed.
    Use Profile        Bendiocarb is a carbamate insecticide used to control household pests,
                   ornamental plant pests, mosquitoes, and fire ants.  Bendiocarb is registered for a
                   variety of indoor (homes and commercial establishments), outdoor (ornamental plants,
                   lawns and golf courses) as well as greenhouse uses. Bendiocarb is manufactured into

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                      several forms: granular, wettable powder, dust, pellets, pressurized liquid, and pet
                      collars. Bendiocarb is applied by the following methods:  broadcast, band treatment,
                      foliar application, dusting, crack and crevice, premise treatment and mound drench.
    Reg UI atO ry        Bendiocarb was first registered for use in the United States in 1980. EPA issued
         History   a Registration Standard for Bendiocarb in October 1987 (PB540/RS-88-122).  A
                      March  1995 and October  1995 Data Call-In (DCI) required additional data for
                      Bendiocarb.  Currently, there are 48 bendiocarb products registered.
Human Health
  Assessment
Toxicity
      For oral exposure, bendiocarb is in Acute Toxicity Category I, the highest of
four categories for this effect. In addition, bendiocarb is in Acute Toxicity Category
II for dermal and inhalation routes of exposure, Acute Toxicity Category III for
primary dermal irritation and Acute Toxicity Category IV for primary eye irritation.
The existing studies with acute and subacute administration of bendiocarb indicate a
rapid onset of cholinesterase inhibition and accompanying symptoms.
      The subchronic and chronic toxicity studies demonstrate that bendiocarb inhibits
cholinesterease activity in whole blood, plasma,  and brain in rats, mice and dogs.
Bendiocarb does  not produce  delayed neurotoxicity in the hen.  Bendiocarb is
classified as a "Group E"  chemical, showing no evidence of carcinogenicity in
laboratory animals or in humans. Developmental and reproductive toxicity studies did
not show evidence of increased susceptibility of rat or rabbit fetuses following in utero
exposure or in offspring following pre- and/or post-natal exposure.  There was no
evidence of mutagenicity following in vivo  or  in vitro exposure to bendiocarb.
Metabolism studies conducted with rats, mice, hamsters, dogs and humans all indicate
that bendiocarb is rapidly absorbed following oral exposure, and the majority of the
administered dose is eliminated in the urine.
      For occupation and  residential short term dermal  exposure, the  endpoint
selected for risk assessment was whole blood cholinesterase inhibition at the lowest
observed adverse effect level (LOAEL) of 100 mg/kg/day in a 21-day dermal toxicity
study in rats; the short-term no observed adverse effect level (NOAEL) in this study
was 50 mg/kg/day. A NOAEL was not established for multiple exposures, therefore
an additional uncertainty factor of 3X was applied to both residential and occupational
intermediate term assessments. For occupational and residential inhalation exposure,
the  endpoint was whole blood cholinesterase inhibition at the LOAEL of 0.0013 mg/L
in a 90-day rat inhalation toxicity study; the NOAEL was 0.0018 mg/L.
      For the chronic dietary risk assessment, the endpoint selected was whole blood
cholinesterase inhibition at the LOAEL of 0.25 mg/kg/day in a special  14-day oral
toxicity  study in  rats; the NOAEL in this study was 0.125 mg/kg/day.  Thus the
reference dose (RfD) for the chronic dietary assessment is 0.00125 mg/kg/day. The

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only dietary exposure to bendiocarb may result from crack and crevice use in food
service establishments.  Bendiocarb has retained the 3-fold FQPA  safety  factor
because of data gaps for acute and subchronic neurotoxicity studies in rats. This factor
is applied to dietary and residential assessments.  The chronic population adjusted
dose (cPAD), which is the reference dose divided by the FQPA safety  factor,  is
0.0004 mg/kg/day

Dietary Exposure
      Bendiocarb is not registered for use on either food or feed crops.  The only
food-related  use  is the spot and crack and crevice treatment of food service
establishments. An acute dietary exposure assessment is  not required for pesticides
having only food  handling establishment tolerances. However,  a chronic dietary
exposure analysis was conducted. The Anticipated Residue Concentration (ARC) for
the overall U.S. population represents 3 % of the Population Adjusted Dose (PAD),
or amount believed not to cause adverse effects if consumed daily over  a 70-year
lifetime. The most highly exposed subgroup, non-nursing infants less than one year old,
has an ARC which represents 13 % of the PAD. This low fraction of the  allowable
PAD is considered to be an acceptable dietary risk.
      Using model estimates, the Agency has calculated drinking water levels of
concern (DWLOCs) for bendiocarb. The only estimated environmental concentrations
(EECs) of concern were for surface water which exceeded the acute DWLOCs for
the general population and  children.   The estimated peak  acute surface  water
concentrations for ground spray and granular application to turf range from 185 to 202
parts per billion (ppb), respectively.

Occupational and Residential Exposure
      Based on the use patterns of bendiocarb, occupational and residential exposures
could occur with the granular, wettable powder, dust, pellet, pressurized liquid and pet
collar formulations. A total of 43 exposure scenarios were evaluated to estimate
potential exposure and risk during mixing/loading, application and post- application
activities.
      Examples of how bendiocarb products could be  applied by a homeowner
include: on carpet, furniture, baseboards and floors for treatment of household pests;
and on outdoor ornamental plants and turf. The risk assessment showed exposure of
the homeowner through several scenarios such as mixing, loading,  or applying
bendiocarb liquid with a sprayer,  dust with a sprinkling can, and granular product with
a spreader or an aerosol product. Most of these scenarios indicated risks of concern
to the homeowner through both dermal and inhalation routes of exposure.  For post-
application exposure,  children are at risk from exposure to bendiocarb through
ingestion by incidental hand to mouth transfer, mostly from treated carpet,  furniture,
indoor surfaces, and outdoor lawns and as the result of touching treated surfaces and

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                       absorbing bendiocarb through their skin. Workers are exposed to bendiocarb through
                       mixing,  loading or applying products in homes and commercial buildings to treat
                       household pests, and through  application of bendiocarb products in greenhouses, on
                       turf, and on ornamental plants. Risk estimates for most of these scenarios show risks
                       of concern for workers.
 Environmental
    Assessment
Environmental Fate
      Laboratory studies indicate a high degree of mobility; however, field studies
indicate that parent bendiocarb generally degrades before leaching through the soil and
the maj or degradate, if detected, is present at low concentrations and remains in upper
soil layers.  Although parent bendiocarb is  sufficiently mobile,  screening models
indicate that bendiocarb is not likely to move through the soil to ground water.
      Bendiocarb can  be  expected to move to surface water through runoff.
Bendiocarb is not likely to accumulate in fish due to its moderate water solubility, and
rapid degradation in water.
                        Ecological Effects
                             The risk assessment for bendiocarb indicates a single broadcast application of
                        a product on turf could result in high acute risks to birds with levels of concern being
                        exceeded at the registered maximum application  rate.  Multiple applications  are
                        expected to result in repeated acute effects.  Due to the lack of data on avian
                        reproduction, chronic effects could not be assessed. The risk assessment indicates
                        acute risks  to mammals  when bendiocarb  is used  at the maximum registered
                        application rate.  Bendiocarb is highly toxic to bees.
                             The use of bendiocarb poses acute risks to freshwater fish; however, no chronic
                        risks to freshwater fish are posed by the use of bendiocarb. Bendiocarb use poses
                        both acute and chronic risks to freshwater invertebrates when applied at the registered
                        maximum rate. The risk assessment indicates acute risks to estuarine and marine
                        animals from the use of bendiocarb.  Due to the lack of data, chronic risks to estuarine
                        and marine animals were not calculated.
Additional Data
         Required
      There are several outstanding data requirements for bendiocarb. At a minimum,
acute and subchronic neurotoxicity  studies in rats, a dominant lethal study, several
residue chemistry studies, several ecotoxicity studies and an analysis of bendiocarb for
dioxin and dibenzofuran contaminants would be required if this chemical were to
continue with reregistration.

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Concl USJOn         The terms of the voluntary cancellation include:
                       Some products that are not currently marketed are immediately canceled, with
                        no existing stocks provisions;
                       The registrant can manufacture the technical product until June 30, 2000; a
                        production cap limits the amount that can be produced to 95,000 pounds per
                        calendar year; and
                        End use products used in or around the home canbe sold or distributed by the
                        registrant until October 31, 2000. All bendiocarb products will be canceled as
                        of December 31,2001.

   rOT lYlOTG         For more information about EPA's pesticide reregistration program or the
Information   pesticide bendiocarb,  please contact  Diane Isbell at the Special  Review and
                  Reregistration Division (7508C), OPP, US EPA, Washington, DC 20460; telephone
                  703-308-8154.
                        Electronic copies of this fact sheet and other REDs are available on the Internet.
                  Please see http://www.epa.gov/REDs.
                        For information about the health  effects of pesticides, or for assistance in
                  recognizing and managing pesticide poisoning symptoms, please contact the National
                  Pesticides Telecommunications Network (NPTN).  Call toll-free 1-800-858-7378,
                  between 9:30 am and 7:30 pm Eastern Standard Time, seven days a week. The
                  NPTN website is http://www.ace.orst.edu/info/nptn.

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