Health Effects Assessment Summary Tables Annual 1995


&EPA
           United States
           Environmental Protection
           Agency
                Office of
                Solid Waste and
                Emergency Response
9200.6-303(95-1)
EPA/540/R-95/036//
PB95-921199
May 1995
           Superfund
Health Effects Assessment
Summary Tables

FY-1995 Annual

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                                            9200.6-303(95-1)
                                           EPA 540/R-95-036
                                               PB95-921199
                                                  May 1995
    HEALTH EFFECTS ASSESSMENT

          SUMMARY TABLES


            FY-1995 Annual
        U S Environmental Protection Agency
        Region 5, Library (PL-12J)
        77 West Jackson Boulevard, IZtn Moor
        Chicago, IL  60604-3590
    Office of Research and Development
Office of Emergency and Remedial Response
   U.S. Environmental Protection Agency
         Washington, DC 20460

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                                   DISCLAIMER
      This report has been prepared by the U.S. Environmental Protection Agency. The
information contained herein has been taken from final documents prepared by the Office of
Health and Environmental Assessment (hereafter referred to as the National Center for
Environmental Assessment) for the Office of Solid Waste and Emergency Response and the
Office of Water, Washington, DC and the Office of Air Quality Planning and Standards,
Research Triangle Park, NC. These documents were reviewed in accordance with Agency
policy and approved for publication.  Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.

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INTRODUCTION

This document is the FY95 Annual Update of the Health Effects Assessment Summary
Tables (HEAST) prepared by EPA's National Center for Environmental Assessment, Cincinnati,
OH (NCEA-CIN) for use at both Superfund and RCRA sites. It completely replaces all former
editions and supplements of the HEAST.
This version of the HEAST will be updated by a November 1995 Supplement. The
supplement will supercede the information in this document, the May 1995 HEAST Annual
Update. Therefore, if the supplement is available it should be checked whenever this document
is consulted. The supplement, however, will not be produced to stand alone and will not
contain the User's Guides or Appendix that are available in the annual update. Thus, the user
should refer to the May 1995 HEAST Annual Update for this information.
The HEAST is a comprehensive listing consisting almost entirely of PROVISIONAL
RISK ASSESSMENT INFORMATION relative to oral and inhalation routes for chemicals of
interest to Superfund, the Resource Conservation and Recovery Act (RCRA), and the EPA in
general. These entries in the HEAST are limited to chemicals that have undergone review and
have the concurrence of individual Agency Program Offices, and each is supported by an
Agency reference. This risk assessment information has not, however, had enough review to
be recognized as high quality, Agency-wide consensus information.
The Integrated Risk Information System (IRIS) is the Agency's official repository of
Agency-wide consensus chronic human health risk information. IRIS evaluations are
conducted by the Agency's Work Group Review process, i.e., they have been examined by
either the Reference Dose/Reference Concentration (RfD/RfC) Work Group or the Carcinogen
Risk Assessment Verification Endeavor (CRAVE) Work Group. These Agency Work Groups
conduct a process that leads to internal Agency scientific consensus regarding risk assessment

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information on a chemical. This information is recorded on IRIS, is considered to be "Work

Group Verified," and does not appear on the HEAST. Thus, provisional risk assessment fl

information on the HEAST is subject to possible review and revision by these Agency Work

Groups.

There are two exceptions to the above discussion. The HEAST also contains

information on chemicals that are a part of the National Ambient Air Quality Standards

(NAAQS) or the Drinking Water Criteria Document (DWCD) series. In each of these cases, the

chemicals are subject to extensive scientific peer review processes of extremely high quality.
CHEMICAL STATUS DEFINITIONS

Chemicals reviewed by the Agency Work Groups are classified according to their status

as either "verified," "not verifiable," or "under review." The toxicity values (other than NAAQS or

DWCD values) listed on the HEAST are considered to be "provisional." The Agency has no

official definitions for these terms, but the HEAST user may interpret them as follows:

Provisional: A toxicity value or a cancer value is "provisional" if the value has
had some form of Agency review, but it does not appear on the IRIS system.
These values are generated in several ways. Often they are determined in the
course of developing an Agency document on a chemical or on a class of
chemicals. Some have been generated through the Work Group process, but
have not yet been input to the IRIS system. At the time each value was derived,
all available information on the chemical was evaluated, the value was calculated
using the most current methodology, and a consensus was reached on the value
by Agency scientists.

Brackets are placed around the names of toxicity and carcinogenicity values on
the HEAST to distinguish these "provisional" values from information on IRIS.
The following names are affected: RfD to [RfD], RfC to [RfC], slope factor to
[slope factor], EPA group to [EPA Group] and unit risk to [unit risk].

These "provisional" values are found on the HEAST. They do not appear
on IRIS.

Verified: A toxicity value or a cancer value is "Work Group Verified" if all
available information on the value has been examined by an Agency Work
Group, the value has been calculated using current Work Group methodology, a
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unanimous consensus has been reached on the value by the Work Group, and
the value appears on IRIS.

Some numbers that have achieved unanimous concensus by the Work Group
may appear on the HEAST for a short time until they are loaded onto IRIS, at
which time they are termed, "verified." During the interim, they are considered to
be "provisional" values that are still "under review" by the Work Group.

These "verified" numbers only appear on IRIS. They do not appear on the
HEAST.

Not verifiable: A toxicity value is "not verifiable" if an Agency Work Group has
considered all available data on a chemical and has unanimously determined
that data are inadequate to generate a value that would be suitable for inclusion
on IRIS. No toxicity value is calculated; no toxicity value is available for IRIS or
the HEAST.

This "not verifiable" status is noted on IRIS, and is sometimes found on
the HEAST, with a pointer to the IRIS system.

Under Review: A toxicity value is "under review" if an Agency Work Group is in
the process of considering all available data on a chemical. All Work Group
chemicals will have this status until the toxicity value is placed on the IRIS
system. Toxicity values that have been withdrawn from IRIS by a Work Group
for further review will have this status.

This "under review" status may be indicated on IRIS or on the HEAST.
During this time, "provisional" toxicity values may appear on the HEAST.
In all cases, the status of a chemical may change as new data become available, and

the assessment is revisited.

CAUTION

It is imperative for each user of the HEAST to recognize that the values listed in the

toxicity tables and the cancer table are generally considered to be PROVISIONAL RISK

ASSESSMENT INFORMATION. The user is referred to IRIS for "Work Group Verified" values.

It is also important to remember that the numbers in these tables alone tell very little about the

adverse effects of a chemical or the quality of evidence on which risk assessment information is

based. Original assessment documents must be consulted by users of the HEAST in order to
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fully appreciate the strengths and limitations of a specific data base. Original source
documents will allow for the most complete characterization of potential toxicity associated with
the range of exposure pathways generally evaluated at Superfund and RCRA sites. The
Reference Tables point the user to these sources.

CONTRIBUTORS
Chemicals commonly found at RCRA sites as identified by the Office of Solid Waste's
(OSW) Technical Assessment Branch are included in the HEAST. The Office of Radiation
Programs has provided data on radionuclide carcinogenicity for Table 4. Finally, the Office of
Air Quality Planning and Standards (OAQPS) has provided information on chemicals for which
Air Quality Criteria Documents and National Ambient Air Quality Standards have been
developed.

CHEMICALS LISTED
Most of the chemicals included on the toxicity tables and carcinogenicity table are those
for which at least one of the following EPA documents has been written: Health Effects Assess-
ment Document (HEA), Health and Environmental Effects Profile (HEEP), Health and
Environmental Effects Document (HEED), Health Assessment Document (HAD), Air Quality
Criteria Document (AQCD), Drinking Water Criteria Document (DWCD). A description of each
is provided in Appendix A, Section I. In a few cases, the values are supported by other written
material, such as Work Group meeting notes or Carcinogen Assessment Group (CAG) Profiles.
Radionuclide slope factor values are calculated by the EPA's Office of Radiation Programs.
The names of criteria pollutants that are regulated as National Ambient Air Quality
Standards (NAAQS) under the Clean Air Act are listed in the main body of the HEAST, but the
actual criteria are included as Section V of Appendix A: Technical Information. The NAAQS
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were not included in the tables in order to distinguish them from the reference concentration

([RfC]) values. The NAAQS and [RfCJs represent different levels of review and different

methods of calculation and thus, must be interpreted and used differently.

HIERARCHY OF SOURCES

It is recognized that at any point in time there may be multiple old and new Agency

documents or data bases that present different values on a specific chemical. For chemicals

other than those represented by the NAAQS or DWCDs, the following hierarchy of sources is

recommended in evaluating chemical toxicity for Superfund sites:
1. The Agency's Integrated Risk Information System (IRIS) and cited
references. Changes are made in this data base on a monthly basis, but
there may be data gaps. Call RISK INFORMATION HOTLINE at
(513)569-7254 for further information.

2. The Health Effects Assessment Summary Tables (HEAST) and cited
references.

3. Consultation with the Superfund Health Risk Technical Support Center
(TSC) at (513)569-7300.

4. Do not consult either the toxicity tables (Appendix A) in the Superfund
Public Health Evaluation Manual (SPHEM, U.S. EPA, 1986) or the
September 1988 Public Health Risk Evaluation Data Base (PHRED) as
these sources are likely to contain numerous values that have since
become out-of-date.
QUESTIONS

Chemical Toxicity and Carcinogenicity

Regional EPA Superfund Staff may direct questions regarding the contents of the

chemical toxicity and carcinogenicity tables on the HEAST (e.g., chemicals not covered,

chemicals with pending [RfD]s) to EPA's Superfund Health Risk Technical Support Center
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(TSC) in Cincinnati, OH at (513)569-7300.  Questions from other users must be submitted to

the TSC in writing and must contain the following information:


      •   Superfund site name, site location and twelve-digit site number;

      •   Name and phone number of the site Remedial Project Manager (RPM) or
          Regional Risk Assessor/Toxicologist;

      •   Detailed description of the risk assessment related question.


      Please send requests via mail or FAX to:

        Superfund Health Risk Technical Support Center
        US EPA
        26 W. ML King Dr.
        National Center for Environmental Assessment
        MS 117
        Cincinnati, OH 45268
        FAX#: (513)569-7159


RCRA Chemicals

      Questions about RCRA chemicals may be addressed by calling the Office of Solid

Waste at (202)260-4761.

Radionuclide Carcinogenicity

      Questions concerning radionuclide carcinogenicity should first be addressed by

contacting the appropriate Regional Radiation Program Manager. A listing of these managers

and several contacts in the Office of Radiation Programs can be found in Exhibit 2 of the User's

Guide - Radionuclide Carcinogenicity.



REFERENCES

      Most cited Agency references (e.g., HEAs, HEEPs, HEEDs), are (or will soon be)

available through the National Technical Information Service (NTIS), 5285 Port Royal Road,
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 Springfield, VA 22161 [(703)487-4650].  Carcinogen Assessment Group (GAG) Profiles cited in

 Table 3 are available through the RCRA docket

 (202)260-9327.

       Drinking water documents are available by calling the Drinking Water Docket at

 (202)260-3027.



 ORDERING INFORMATION

       Limited copies of the HEAST are available for EPA Superfund staff, State Superfund

 programs and other Federal agencies working on Superfund sites, and EPA contractors

 working for the EPA Superfund program. Users in these groups can call Syracuse Research

 Corporation (202)479-0881 to be put on the mailing list.

       EPA's Office of Solid Waste (OSW) requests that their users (i.e., OSW staff,

 contractors, State solid waste programs) call the Health Assessment Section (202)260-4761 to

 obtain copies of the HEAST. Regional OSW staff are reminded that copies are sent to all EPA

 Regional libraries.

       Users of the HEAST in EPA's Office of Air and Radiation and State air programs should

 call Kelly Rimer of EPA's Office of Air Quality Planning and Standards at (919)541-2962.

       All other users must purchase the document from:

        National Technical Information Service (NTIS)
        5285 Port Royal Road
        Springfield, VA  22161
        (703)487-4650


       For ordering information, call the NTIS Subscriptions Department at (703)487-4630.

 NTIS normally ships 4th  class United States mail. When ordering the 1995 Health Effects

Assessment Summary Table annual update from NTIS refer to the following order number:

                   PB95-921199: FY95 Annual HEAST update
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STRUCTURE OF THE HEAST

      The HEAST Introduction contains explanatory material relative to the quality of

information on the HEAST, its sources, and its availability. This is followed by a listing of

changes since the last HEAST was published and then by User's Guides for both Chemical

Toxicity and Carcinogenicity, and Radionuclide Carcinogenicity.  The values on the HEAST are

presented in a series of five tables that contain toxicity information and three tables of

references. The information contained in each table and their designations are as follows:
      HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
      CARCINOGENICITY)
      Table 1 lists subchronic and chronic non-cancer toxicity values that were
      calculated using the current methodology practiced by the RfD/RfC Work Group.

      HEAST TABLE 1 REFERENCES: SUBCHRONIC AND CHRONIC TOXICITY (OTHER
      THAN CARCINOGENICITY)
      The references for Table 1 are numerically coded to associate each toxicity
      value clearly with its corresponding reference.
      HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC
      TOXICITY (OTHER THAN CARCINOGENICITY)
      Table 2 lists subchronic and chronic non-cancer toxicity values that are found in
      Agency documents, but were calculated by alternative methods that are not
      currently practiced by the RfD/RfC Work Group. These values are considered to
      be adequate provisional values for risk assessment purposes at Superfund and
      RCRA sites, but are subject to being reviewed by the RfD/RfC Work Group and
      revised when necessary to reflect current work group practices.

      HEAST TABLE 2 REFERENCES:  ALTERNATE METHODS - SUBCHRONIC AND
      CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
      The references for Table 2 are numerically coded to associate each toxicity
      value clearly with its corresponding reference.

      HEAST TABLE 3: CARCINOGENICITY
      Table 3 lists Carcinogenicity values that were calculated using the current
      methodology of the CRAVE Work Group.

      HEAST TABLE 3 REFERENCES:  CARCINOGENICITY
      The references for Table 3 are numerically coded to associate each toxicity
      value clearly with its corresponding reference.
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      HEAST TABLE 4: RADIONUCLIDE CARCINOGENICITY - SLOPE FACTORS
      (In Units of Picocuries)
      Table 4 lists ingestion, inhalation and external exposure carcinogenicity slope
      factors for radionuclides in units of picocuries and a factor to convert into the
      International System (SI) activity units of becquerels (Bq).
      Following the tables, a Technical Appendix (Appendix A) is available, containing the

following sections:


      I.   Data Sources and Selection Criteria Used in HEAST

      II.  Dose Conversions on HEAST

      III.  Chemical Name and Chemical Abstracts Service
            Registry Number Cross Reference

      IV.  Effect Level Definitions

      V.  National Ambient Air Quality Standards (NAAQS)
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                 WHAT'S NEW IN THE FY95 ANNUAL HEAST

GENERAL CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY

    The changes in this version of the HEAST reflect changes in IRIS through May 1,

1995. It is also current with RfD/RfC and CRAVE Work Group activities through May 1,

1995.
CHEMICAL-SPECIFIC CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY
A.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 1: SUBCHRONIC AND
    CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

Aroclor1254 011097-69-1
An indicator was added to show that the chronic oral RfD is now on IRIS.  The chronic
oral RfD is adopted as the subchronic oral [RfD].

Endosulfan  000115-29-7
An indicator was added to show that the chronic oral RfD is now on IRIS.

Mercuric Chloride 007487-94-7
This is a new entry to the table with a comment indicating that the chronic oral RfD was
adopted as the subchronic oral [RfD].

Mercury. Inorganic 007439-97-6
The HEAST entry is changed to Mercury. Elemental and a comment indicating that the
chronic [RfC] is under review.

Methvlmercurv 022967-92-6
A critical oral dose entry is indicated with a change in target and critical effect. The
subchronic [RfD] is also changed from 3E-4 to 1E-4. A comment is added to indicate
that a benchmark dose approach was used to derive the RfD.

Metribuzin 021087-64-9
The subchronic oral [RfD] was removed because the chronic oral RfD upon which it is
based in under review by the RfD/RfC Work Group.

Nickel (Metallic) 007440-02-0
The HEAST entry is changed to Nickel. Soluble Salts. "Various" is used for CAS
registry number since there is none for salts. A comment was added to indicate that
the chronic oral [RfD] was derived from the nickel moiety of the administered nickel
chloride salt.
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 B.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 2: ALTERNATE
     METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
     CARCINOGENICITY)

 Nitrobenzene 000098-95-3

 A typographical error was discovered in earlier issues of HEAST Table 2.  The
 subchronic [RfC] comment should read 6E-3 mg/kg/day, and  has been corrected
 accordingly.

 C.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3: CARCINOGENICITY

 Dichlorobenzene. 1.4-000106-46-7
 Carcinogenicity value in HEAST Table 3 is changed to reflect 1987 FR (July 8)
 52:25690-25717.

 Mercuric Chloride 007487-94-7
 An indicator was added to show that the EPA Group Classification is available on IRIS.

 Mercury. Elemental 007439-97-6
 An indicator was added to show that the EPA Group Classification is available on IRIS.

 Methvlmercury 0022967-92-6
 An indicator was added to show that the EPA Group Classification is available on IRIS.

 Nitrobenzene 000098-95-3
 The EPA Group Classification under review by the CRAVE Work Group was added to
 Table 3.

 D.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE: RADIONUCLIDE
    CARCINOGENICITY - SLOPE FACTORS

 CHEMICAL SPECIFIC CHANGES MADE IN THE JULY 1994 SUPPLEMENT NO.  1
 AND THE NOVEMBER 1994 SUPPLEMENT NO. 2 TO THE MARCH 1994 HEAST
 ANNUAL UPDATE

 The following changes were made in the July 1994 and November 1994 supplemental

 editions of the March 1994 HEAST Annual Update and represent changes that have

 occurred between the publication of the March 1994 HEAST Annual  Update and this

document, the May 1995 HEAST Annual Update. Because some HEAST users may

have been unaware of the publication of these supplements, the following information


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will indicate additional changes in toxicity information that should be noted. [Note:

These changes have been incorporated into the May 1995 Annual Update.]
A.  CHEMICAL-SPECIFIC CHANGES IN THE JULY 1994 AND NOVEMBER 1994
SUPPLEMENTS ON HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)

Acetone cvanohvdrin / (2-Methvllactonitrile) QQOQ75-86-5
The chronic oral [RfD] now under review by the RfD/RfC Work Group was added to
Table 1. The chronic oral [RfD] was modified to derive the subchronic oral [RfD]. The
synonym used by the RfD/RfC Work Group in its latest review is now included in
HEAST.

Acrolein 000107-02-8
The subchronic [RfD] and [RfC] Risk Assessment Issue Papers for this compound were
not reexamined by ECAO this year and the comment to contact the Superfund Health
Risk Technical Support Center was removed from HEAST.  No further change to the
table.

Acrvlic acid 000079-10-7
The chronic oral RfD has been replaced on IRIS.  The chronic oral RfD on IRIS was
adopted as the subchronic oral [RfD].

Anthracene 000120-12-7
A comment was added to indicate that the chronic inhalation [RfC] is considered not
verifiable (08/04/94) by the RfD/RfC Work Group.

Aroclor1248 012672-29-6
An indicator was added to show that a comment is now on  IRIS that the chronic oral
RfD is considered not verifiable by the RfD/RfC (07/20/93) Work Group.

Aroclor1254 012672-29-6
The chronic oral [RfD] under review by the RfD/RfC Work Group was added to the
table. The chronic oral [RfD] was modified to derive the subchronic oral [RfD].

Benzofatenthracene QQOQ56-55-3
A comment was added to indicate that the chronic inhalation [RfC]  is considered not
verifiable (08/04/94) by the RfD/RfC Work Group.
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J
Caprolactam  QQQ1Q5-60-2
An indicator was added to show that a comment is now on IRIS that the chronic
inhalation RfC is considered not verifiable (08/03/94) by the RfD/RfC Work Group.

Carbon disulfide 000075-15-Q
No change to the table.  Reference to the 1989 RfD/RfC Work Group was added.

Chlordane 000057-74-9
The subchronic [RfC] Risk Assessment Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST.  No further change to the table.

Dacthal 001861-32-1
The chronic oral RfD has been  replaced on IRIS. The chronic oral RfD on IRIS was
adopted as the subchronic oral [RfD].

Dibromoethane. 1.2- 000106-93-4
The subchronic inhalation [RfC] was modified to be consistent with the chronic
inhalation [RfC].

Dichlorobenzene. 1.2- 000095-50-1
The subchronic [RfD] Risk Assessment Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST.  No further change to the table.

Dichloroethane. 1.2- 000107-06-2
The subchronic [RfD] and [RfC] Risk Assessment Issue Papers for this compound were
not reexamined by NCEA this year.  The comment to contact the Superfund Health Risk
Technical Support  Center was the only  information on Table 1, therefore the compound
was removed from Table  1.

Dimethylphthalate  000131-11-3
The chronic oral [RfD] has been removed. A comment was added to show that the
chronic oral [RfD] is considered not verifiable by the RfD/RfC (02/16/94) Work Group.

Fluoranthene  000206-44-0
A comment was added to indicate that the chronic inhalation [RfC] is considered not
verifiable (08/04/93) by the RfD/RfC Work Group.

Hexachlorobenzene  000118-74-1
The subchronic [RfD] Risk Assessment  Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST. No further change to the table.
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Hexachlorobutadiene 000087-68-3
The subchronic [RfC] Risk Assessment Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST.  No further change to the table.

Methylenediphenvl isocyanate. 4.4- / (Diphenylmethanediisocyanate) 000101-68-8
An indicator was added to show that the chronic inhalation RfC is now on IRIS. The
chronic inhalation RfC on IRIS was adopted as the subchronic inhalation [RfC].

Nitric oxide 010102-43-9
The chronic oral RfD for this compound has been permanently withdrawn (09/01/94)
from IRIS.

Nitrogen dioxide  010102-44-0
The chronic oral RfD for this compound has been permanently withdrawn (09/01/94)
from IRIS. The subchronic oral [RfD] was removed from HEAST.

Phenanthrene 000085-01-8
A comment was added to indicate that the chronic  inhalation [RfC] is considered  not
verifiable (08/04/94) by the RfD/RfC Work Group.

Pyrene OOP 129-00-0
A comment was added to indicate that the chronic  inhalation [RfC] is considered  not
verifiable (08/04/94) by the RfD/RfC Work Group.

Styrene 000100-42-5
The subchronic [RfD] Risk Assessment Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST.  No further change to the table.

Trichloroethane. 1.1.1- QQQ071-55-6
A comment pertaining to  the subchronic [RfC] was added to the table.


B.  CHEMICAL-SPECIFIC CHANGES IN THE JULY 1994 AND NOVEMBER 1994
SUPPLEMENTS ON HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC
AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

    No changes were made to HEAST Table 2.
ft
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 C.  CHEMICAL-SPECIFIC CHANGES IN THE JULY 1994 AND NOVEMBER 1994
     SUPPLEMENTS ON HEAST TABLE 3: CARCINOGENICITY

 Bis(2-chloroisopropyh ether 039638-32-9
 Removed from Table 3. Compound tested was Technical bis(2-chloro-1-methylethyl)
 ether containing 70% bis(2-chloro-1-methylethyl) ether and 30% bis(2-
 chloroisopropyl) ether.  [Slope factor], [unit risk], and [EPA Group] classification were
 only derived for bis(2-chloro-1-methylethyl) ether.

 Bis(2-chloro-1 -methvlethyh  ether 000108-06-1
 Replaced on Table 3. Compound tested was Technical bis(2-chloro-1-methy(ethyl)
 ether containing 70% bis(2-chloro-1-methylethyl) ether and 30% bis(2-
 chloroisopropyl) ether.  [Slope factor], [unit risk], and [EPA Group] classification were
 only derived for bis(2-chloro-1-methylethyl) ether.

 Dimethvlhvdrazine. 1.2- 000540-73-8
 The general comment, "Contact the Superfund Health Risk Technical Support Center"
 has been removed from the table.

 Vinvl  chloride 000075-01-4
 No change in values. The General Comment was changed to reflect additional review
 by the CRAVE Work Group.

 D. CHEMICAL-SPECIFIC CHANGES IN THE JULY 1994 AND NOVEMBER 1994
 SUPPLEMENTS ON HEAST TABLE 4: RADIONUCLIDE CARCINOGENICITY -
 SLOPE FACTORS

    EPA's Office of Radiation and Indoor Air (ORIA) has recently revised its

 methodology for estimating radiogenic cancer risks and for deriving radionuclide slope

 factors1.  Specifically, ORIA  has:

 /  revised its  risk models for potential cancer sites based on current epidemiological
    data on radiogenic cancers in  humans and on recent recommendations of the
    National Academy of Sciences (NAS) Biological Effects of Ionizing Radiation
   1 Radionuclide ingestion and inhalation slope factors are central estimates in a linear model of the age-
averaged, lifetime attributable radiation cancer incidence (fatal and nonfatal cancer) risk per unit of activity
inhaled or ingested, expressed as risk per picocurie (pCi).  External exposure slope factors are central estimates
of lifetime attributable radiation cancer incidence risk for each year of exposure to external radiation from
photon-emitting radionuclides distributed uniformly in a thick layer of soU, and are expressed as risk/yr per
pCi/g soil.


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    (BEIR) Committee2, the International Commission on Radiological Protection
    (ICRP)3, and the U.S. Nuclear Regulatory Commission (NRC)4; (EPA's previous
    radiogenic cancer risk models were based primarily upon MAS BEIR III Committee
    recommendations.)

/   incorporated a dose and dose rate effectiveness factor (DDREF) of 2 for low-LET
    radiation for all cancer sites except breast (DDREF=1) whenever the total dose is
    below 20 rad (0.2 Gy) or the dose rate is below 10 mrad/min (0.1 mGy/min); (In
    EPA's previous methodology, a value of DDREF=1 was assumed for low-LET
    radiation for all cancer sites. For high-LET alpha radiation, EPA has retained the
    value of DDREF=1.)

/   revised the relative biological effectiveness (RBE) for alpha particles to RBE=20 for
    all cancer sites except breast (RBE=10) and leukemia (RBE=1); (In the previous
    methodology, EPA assumed a value of RBE=8 all cancer sites with the exception
    of leukemia (RBE=1.117).)

/   taken survival data and vital statistics from the U.S. Decennial Life Tables for
     1979-1981; (Previously, EPA used life table data for the 1970 decennial U.S.
    population  in the calculation of radionuclide slope factors.)

/    revised its method for integrating vital statistics and risk models for reference
     populations;

/    re-evaluated and revised (as appropriate) the radiation dose estimates used to
     derive the slope factors;

/    increased the Agency's estimate of the lifetime fatal cancer risk associated  with
     uniform, whole-body irradiation of the U.S. population from low-LET radiation at
     low doses and dose rates by approximately 24% from 392 to 509 per 106 person-
     rad (392 to 509 per 10" person-Gy); and

/    increased the Agency's cancer morbidity  risk estimate from 623 to 761 per  106
     person-rad (623 to 761 per 104 person-Gy).
    2 National Academy of Sciences (1990). Health Effects of Exposure to Low Levels of Ionizing Radiation.
BEIR V. Committee on the Biological Effects of Ionizing Radiations, National Research Council, Washington,
D.C.

    3 International Commission on Radiological Protection (1991), 1990 Recommendations of the International
Commission on Radiological Protection. ICRP Publication 60, Pergamon Press, New York, NY.

    4 U.S. Nuclear Regulatory Commission (1991, 1993), Health Effects Models for Nuclear Power Plant
Accident Consequence Analysis. NUREG/CR-4214. Addenda documenting the scientific basis for radiogenic
risk models published in 1991 (for low-LET radiation) and 1993 (for alpha radiation). See EPA 402-R-93-076
for discussion of these models.

                                        -16-

-------
     As a result of these changes in risk assessment methodology, assumptions, and



 calculations, ORIA has also rederived its lifetime excess cancer incidence slope factors



 for all radionuclides listed in previous HEAST updates and for a few new radionuclides



 added to this update. The HEAST User's Guide on Radionuclide Carcinogenicity



 provides an overview of ORIA's revised methodology for deriving radionuclide slope



 factors, and interested users are directed to Estimating Radiogenic Cancer Risks (EPA



 402-R-93-076) for a more detailed discussion of ORIA's approach and assumptions.








     For simplicity and to minimize the possibility of confusion and errors, this HEAST



 update includes a single table—Table 4—of radionuclide slope factors in customary



 activity units of picocuries (pCi) only, consistent with the reporting format for



 radionuclide slope factors in EPA's Integrated Risk Information  System (IRIS) data



 base.  Previous HEAST updates presented radionuclide slope factors in both



 customary units and the International System (SI) units of becquerels  (Bq) in Tables 4A



 and 4B, respectively.








     Similar to the former HEAST Tables 4A and 4B, the new Table 4  provides



 reference toxicity  information for each radionuclide, including a Chemical Abstract



 Service Reference Number (CASRN), radioactive half-life, lung  clearance classification



and gastrointestinal (Gl) absorption factor (where appropriate). It should be noted that



the Gl absorption  factors, lung classifications and radioactive half-lives are provided in



HEAST Table 4 for reference only and should not be used to correct, modify, or in any



way adjust radionuclide slope factors or intake assumptions in risk calculations.




                                     -17-

-------
    Inhalation, ingestion and external exposure slope factors for radionuclides marked

with the suffix "+D" in Table 4 include the added risks from associated radioactive

decay chain products with half-lives less than or equal to six months, assuming

equilibrium with the principal or parent radionuclide in the. environment. (Note that slope

factors for all radionuclides always account for associated decay products created

within the body after intake.)



    In summary, key features of this HEAST update for radionuclides are:

«a- All radionuclide ingestion, inhalation and external exposure cancer slope
   factors have been updated to incorporate EPA's revised methodology for
   estimating radiogenic cancer risk.

KT Table 4 presents radionuclide slope factors in customary activity units of
   picocuries (pCi) only, consistent with EPA's IRIS data base format for
   radionuclides.

us" Additional slope factors are now provided for the following six radionuclide
   decay chains:
   Ag-108m+D, Ce-144+D, Cm-243+D, Pu-241+D,  Pu-244+D, and Sb-125+D.
                                      -18-

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                     USER'S GUIDE: CHEMICAL TOXICITY








   The HEAST summarizes provisional toxicity and cancer values as well as values



developed for the NAAQS and DWCD chemicals. The provisional status of the toxicity



and cancer values is indicated by placing brackets around the title of the value. These



include provisional reference concentrations ([RfC]) and provisional reference doses



([RfD]) for toxicity from subchronic and chronic inhalation and oral exposure (Tables 1



and 2) and provisional slope factors ([slope factor]), provisional cancer classifications



([EPA Group]) and provisional unit risk values ([unit risk]) for carcinogenicity, based on



lifetime inhalation and oral exposure (Table 3).  Brackets should be included with the



acronym whenever a user quotes the value in an assessment document, and the



provisional nature of the value should be noted. A more complete discussion of how



Superfund develops and considers the toxicity assessment in hazardous waste sites is



presented in Chapter 7 of Risk Assessment Guidance for Superfund Volume 1: Human



Health Evaluation Manual, Part A, EPA/540/1-89/002.



   The references listed for each chemical in the Reference Tables for Tables 1, 2 and



3 represent the study or studies that are the basis for the [RfC], [RfD], [slope factor],



[EPA Group], or [unit risk], as well as the EPA reference that is the source of the



Agency analysis or risk assessment information. In  some cases, additional EPA



documents are also listed as a source of information on the chemical. Work Group



verified values found on IRIS are not found on the HEAST,  but are indicated in the



tables by the word "IRIS" in place of the number.
                                     -19-

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TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINO-
           GENICITY)
      The [RfC] or [RfD] is a provisional estimate (with uncertainty spanning perhaps

an order of magnitude) of the daily exposure to the human population (including

sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects

during a portion of the lifetime, in the case of a subchronic [RfC] or [RfD], or during a

lifetime, in the case of a chronic [RfC] or [RfD]. The [RfC] and [RfD] values are listed in

Tables 1 and 2 in columns with the headings "Subchronic" and "Chronic". The critical

dose or concentration level is usually a No-Observed-Adverse-Effect Level (NOAEL) or

a Lowest-Observed-Adverse-Effect Level (LOAEL) (See Appendix A, Section IV: Effect

Level Definitions, for more information).  The [RfC] or [RfD] is derived by dividing the

NOAEL or LOAEL by an uncertainty factor (UF) times a modifying factor (MF):


                        [RfC] or lRfD]=NOAEL °r LOAEL
                                         UF x MF


In Tables 1 and 2, the information  listed is the following:

Chemical                =  Chemical Name/CASRN
Level                   =  Effect Level
Dose                   =  Administered Dose or Concentration
Route                   =  Route of Administration
Species                 =  Tested Species
Experiment Length       =  Length of Exposure
Target                  =  Target Organ(s) Affected at Critical Level
Critical Effect            =  Effect(s) Observed at Critical Level
Subchronic [RfC]         =  Subchronic Inhalation [Reference  Concentration]
UF                     =  Uncertainty Factor for the Subchronic Inhalation
                           [Reference Concentration]
Subchronic [RfD]         =  Subchronic Oral [Reference Dose]
UF                     =  Uncertainty Factor for the Subchronic Oral [Reference
                           Dose]
Chronic [RfC]            =  Chronic Inhalation [Reference Concentration]


                                     -20-

-------
UF                     =   Uncertainty Factor for the Chronic Inhalation [Reference
                           Concentration]
Chronic [RfD]            =   Chronic Oral [Reference Dose]
UF                     =   Uncertainty Factor for the Chronic Oral [Reference
                           Dose]
Reference               =   Reference Identification Number for All Toxicity Values
                           on the Same Line.
An example of this information is shown in Figure 1, HEAST Table 1:

Chemical               =   GLYCIDALDEHYDE/000765-34-4
Level                  =   NOAEL
Dose                  =   10 PPM
Route                  =   INHALATION: INTERMITTENT
Species                =   RAT
Experiment Length       =   12 WEEKS
Target                 =   WHOLE BODY, BLOOD, KIDNEY
Critical Effect            =   DECREASED WEIGHT GAIN, HEMATOPOIETIC
                           EFFECTS
Subchronic [RfC]        =   1E-2 mg/cu.m
UF                     =   300
Subchronic [RfD]        =   4E-3 mg/kg/day
UF                     =   300
Chronic [RfC]            =   1E-3 mg/cu.m
UF                     =   3000
Chronic [RfD]            =   IRIS
UF                     =   IRIS
Reference              =   005968

Notice that a Chronic RfD for Glycidaldehyde is available on IRIS, so it is not listed
here. Also notice that there are footnotes for this chemical that indicate a route-to-route
extrapolation was performed and that there is information available on Table 3:
Carcinogenicity.
      Also given in Figure 1 is an example of the References for Table 1 for the same

chemical. The reference is identified by the chemical name (Glycidaldehyde), the

CASRN (00765-34-4), and the reference number that links it with the toxicity values

(005968).
                                   -21-

-------
FIGURE 1
Example Data and References for Chemical Toxicity
CHEMICAL
LEVEL ROUTE
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN I CITY) January 1992
SEECJES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu in) (ma/kg/dav) InaZcu ml (mo/kq/dav)
UF UF UF UF
GLYCIDALDEHYDE
NOAEL 10 PPM
INHALATION:
INTERMITTENT
000765-34-4
RAT
12 WEEKS WHOLE BODY
BLOOD
KIDNEY
1E-2
4E-3
1E-3
IRIS
005968
DECREASED WEIGHT GAIN
HEMATOPOIETIC EFFECTS
EFFECTS
300
300
3000
SUBCHRONIC [RfD] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLAriON USING AN ABSORPTION FACTOR OF 0.5.
, GENERAL COMMENT: ALSO SEE TABLE 3: CARCINOGENICITY.
Ni
TO
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
CH. RJ
2: 23-30.
R LIMA AND GS LOQUVAM. 1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH ENVIRON HEALTH.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE : OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. National Center for Environmental Assessment. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC.

-------
      The uncertainty factor used in calculating the [RfC] or [RfD] reflects scientific



judgment regarding the various types of data used to estimate [RfC] or [RfD] values.



An uncertainty factor of 10 is usually used to account for variation in human sensitivity



among populations. An additional 10-fold factor is usually used to account for each of



the uncertainties assumed when extrapolating from animal data to humans, when



extrapolating from a LOAEL to a NOAEL, and when extrapolating from subchronic to



chronic exposure.  In order to reflect professional assessment of the uncertainties of the



study and the data base not explicitly addressed by the above uncertainty factors (e.g.,



completeness of the overall data base), an additional uncertainty factor or modifying



factor ranging from greater than 0 to less than or equal to 10 is applied.  The default



value for this modifying factor is 1.



      For chemicals for which a chronic [RfC] or [RfD] is presented in Tables 1 and 2,



a subchronic [RfC] or [RfD] is usually derived, if not previously derived in the Agency



documents that originally addressed the chemical.  Subchronic toxicity values are not



evaluated by the RfD/RfC Work Group.  The subchronic [RfC] or [RfD] is derived in



either of two ways: 1)  If an uncertainty factor was used to account for extrapolation



from subchronic to chronic exposure in the derivation of the chronic [RfC] or [RfD], then,



the subchronic [RfC] or [RfD] is derived from the same benchmark concentration or



dose without applying the uncertainty factor for subchronic to chronic exposure extrapo-



lation.  2) If the chronic [RfC] or [RfD] was derived without use of an uncertainty factor



for extrapolating from subchronic to chronic exposure (e.g., if chronic data were



available), then, the chronic [RfC] or [RfD] is adopted as the subchronic [RfC] or [RfD].
                                      -23-

-------
      Tables 1 and 2 list the uncertainty factor and modifying factor, multiplied



together, to form a single factor under the heading "Uncertainty Factor."  For example,



the uncertainty factor of 3000 listed for the chronic inhalation [RfC] for Glycidaldehyde



reflects an uncertainty factor of 1000 (10 for human sensitivity, 10 for extrapolation from



animal to human, and 10 for extrapolation from subchronic to chronic) and a modifying



factor of 3 (for an inadequate data base); the uncertainty factor of 500 listed for the



subchronic oral [RfD] for cyanide reflects an uncertainty factor  of 100 (10 for human



sensitivity, and 10 for extrapolation from animal to human) and a modifying factor of 5



(to account for tolerance to cyanide when ingested by food rather than administration



by gavage or by drinking water).



      [RfC] and [RfD] values are specific for the route of exposure for which they are



listed on Tables 1 and 2.  In the few instances where an [RfD]  or [RfC] has been



determined from another exposure route, route-to-route extrapolation is indicated by a




footnote.



      The current methodology for the derivation of inhalation RfCs is detailed in the



document, "Interim Methods for Development of Inhalation Reference Doses" (U.S.



EPA, 1990,  EPA/600/8-88/066F, NTIS PB90-145723).  These  methods are different



from those used for oral RfDs because of (1) the dynamics of the respiratory system



and its diversity across species, and (2) differences in the physicochemical properties of



contaminants  (such as the size and shape of a particle or whether the contaminant is



an aerosol or a gas). Parameters such as deposition, clearance mechanisms and the



physicochemical properties of the inhaled agent are considered in the determination of



the effective dose delivered to the target organ.




                                      -24-

-------
      An RfC value calculated using this interim methodology is generally reported as


a concentration in air (mg/m3), although it may be converted to a corresponding inhaled


dose (mg/kg/day) by dividing by 70 kg (an assumed human body weight), multiplying by


20 m3/day (an assumed human inhalation rate), and adjusting by an appropriate


absorption factor. This conversion, however, may often be technically incorrect, and


the appropriateness of doing this must be evaluated on a case-by-case basis. It is


recommended that HEAST users that plan to use this technique read a further


discussion of the difficulties inherent in this dose conversion that can be found in


Appendix A, Section II: Dose Conversions On HEAST.


      Inhalation [RfC] values reported in HEAs and early HEEDs that were finalized


pfior to the implementation of the interim methods were calculated using methods


similar in concept to those used for oral [RfDJs. These values are reported both as a


concentration in air (in mg/m3 for continuous, 24 hours/day exposure) under the column


[RfC], and as a corresponding inhaled dose (in mg/kg/day) in the footnotes called,


Chronic (Subchronic) [RfC] Comment.  These chemicals are listed in Table 2: Alternate


Methods - Subchronic and Chronic Toxicity (Other Than Carcinogenicity).


      [RfD] values for oral exposure are reported as mg/kg/day. An oral [RfD] value


can be converted to a corresponding concentration in drinking water, assuming human


body weight of 70 kg and water consumption of 2 L/day, as follows:



                     ..  .    .     oral [RfD] (in  mg/kg/day) x 70 kg
                  mglL in water = 	'	—	^—-——	-
                                            2 L/day



      The [RfC] or [RfD] is used as a reference point for gauging the potential effects


of other exposures.  Usually, exposures that are less than the [RfC] or [RfD] are not



                                      -25-

-------
likely to be associated with health risks. As the frequency of exposures exceeding the

[RfC] or [RfD] increases and as the size of the excess increases, the probability

increases that adverse health effects may be observed in a human population.

Nonetheless, a clear distinction that would categorize all  exposures below the [RfC] or

[RfD] as "acceptable" (risk-free) and all exposures in excess of the [RfC] or [RfD] as

"unacceptable" (causing adverse effects) cannot be made. In addition, [RfC] and [RfD]

values, and particularly those with limitations in the quality or quantity of supporting

data, are subject to change as additional information becomes available.

      When [RfC] or [RfD] values are listed  in Tables 1 or 2 for chemicals that are

carcinogens, a footnote will refer to Table 3 if additional information concerning

carcinogenicity is available in that table. [RfC] and [RfD]  values that have been derived

for carcinogens are based on noncancer endpoints only and should not be assumed to

be protective against carcinogenicity.


TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
           (OTHER THAN CARCINOGENICITY)

      Chemicals are listed in Table 2 when the [RfD] or [RfC] was derived from

alternative methods that are not currently practiced by the RfD/RfC Work Group. The

table consists primarily of inhalation [RfC] values determined from methodology that

does not follow the interim inhalation methods adopted by the Agency, and [RfC] or

[RfD] values based on route-to-route extrapolation with inadequate pharmacokinetic

and toxicity data. A footnote is added to each chemical to provide a short explanation

of the specific methodology used in calculating these provisional toxicity values.  Most

of these toxicity values were formerly listed in Table 1. In some instances, the chemical


                                     -26-

-------
 may be listed in both Tables 1 and 2 if the chemical has more than one toxictty value.

 Table 2 follows the same format as Table 1 (refer to Figure 1).



 TABLES:  CARCINOGENICITY

      In assessing the carcinogenic potential of a chemical, the Human Health

 Assessment Group (HHAG) of EPA classifies the chemical into one of the following

 groups, according to the weight of evidence from epidemiologic and animal studies:
     Group A -    Human Carcinogen (sufficient evidence of carcino-
                 genicity in humans)

     Group B -    Probable Human Carcinogen (B1 - limited evidence of
                 carcinogenicity in humans; B2 - sufficient evidence of
                 carcinogenicity in animals with inadequate or lack of
                 evidence in humans)

     Group C -    Possible Human Carcinogen (limited evidence of
                 carcinogenicity in animals and inadequate or lack of
                 human data)

     Group D -    Not Classifiable as to Human Carcinogenicity
                 (inadequate or no evidence)

     Group E -    Evidence of Noncarcinogenicity for Humans (no
                 evidence of carcinogenicity in adequate studies).
These classifications are shown under [EPA Group] on Table 3.

    Quantitative carcinogenic risk assessments are performed for chemicals in Groups

A and B, and on a case-by-case basis for chemicals in Group C.  Cancer [slope factors]

(formerly called cancer potency factors in the Superfund Public Health Evaluation

Manual) are estimated through the use of mathematical extrapolation models, most

commonly the linearized multistage model, for estimating the largest possible linear


                                    -27-

-------
slope (within the 95% confidence limit) at low extrapolated doses that is consistent with

the data. The [slope factor] or risk is characterized as an upper-bound estimate, i.e.,

the true risk to humans, while not identifiable, is not likely to exceed the upper-bound

estimate and in fact may be lower.

     Quantitative carcinogenic estimates listed in Table 3 include the following:

     [slope factor] = risk per unit dose = risk per mg/kg/day

     [unit risk] for inhalation exposure = risk per concentration unit in air
     = risk per ug/m3

     [unit risk] for oral exposure = risk per concentration unit in water =
     risk per ug/L


[Unit risk] estimates for inhalation and oral exposure can be calculated by dividing the

appropriate [slope factor] by 70 kg and multiplying by the inhalation rate (20 m3/day) or

the water consumption rate (2 L/day), respectively, for risk associated with unit

concentration in air or water.  Hence,

risk per ug/m3 (air) = (risk per mg/kg/day) x  1  x20 m3/dayx 103 (mg/ug)
                                       70kg

risk per ug/L (water) = (risk per mg/kg/day) x 1  x2 L/day x 10'3 (mg/ug)
                                         70kg


Quantitative estimates of carcinogenic risk are listed under [Unit Risk] or [Slope Factor]

in Table 3. Information on the study and data set used for estimation of the [slope

factor] is given  in the other columns of Table 3.

     In Table 3, the information listed is the following:

Chemical                        =  Chemical  Name/CASRN
Route                           =  Route of Administration
Species                         =  Tested Species


                                       -28-

-------
 Experiment Length               = Length of Exposure
 Target                          = Target Organ(s) Affected at Critical Level
 Cancer                         = Tumors Observed at Critical Level (Not
                                  Specified if More Than One Type of Tumor)
 [EPA Group]                     = EPA Classification by Weight of Evidence
 Oral [Slope Factor]               = Risk Per Unit Dose
 Inhalation [Slope Factor]          = Risk Per Unit Dose
 Oral [Unit Risk]                   = Risk Per Concentration Unit in Water
 Inhalation [Unit Risk]              = Risk Per Concentration Unit in Air
 Reference                      = Reference Identification Number for All Toxicity
                                  Values on the Same Line.
An example of this information is shown in Figure 2, HEAST Table 3:

Chemical                        =  DIMETHYLHYDRAZINE, 1,2-7000077-78-1
Route                          =  ORAL: DRINKING WATER
Species                         =  MOUSE
Experiment Length                =  LIFETIME
Target                          =  CARDIOVASCULAR SYSTEM
Cancer                         =  TUMORS
[EPA Group]                     =  B2
Oral [Slope Factor]                =  3.7E+1 (MG/KG/DAY)-1
Inhalation [Slope Factor]           =  3.7E+1 (MG/KG/DAY)-1
Oral [Unit Risk]                   =  1.1E-3 (UG/L)-1
Inhalation [Unit Risk]              =  1.1E-2 (UG/CU M)-1
Reference                       =  009993

Notice that the inhalation values for 1,2-Dimethylhydrazine was extrapolated from the
oral data.
    Also given in Figure 2 is an example of the References for Table 3 for the same

chemical.  The reference is identified by the chemical name (Dimethylhydrazine, 1,2-),

the CASRN (000077-78-1), and the reference number that links it with the toxicity

values (009993).

    Quantitative carcinogenic estimates are specific for the route of exposure for which

they are listed on Table 3.  Footnotes are used to indicate those instances in which the

values for inhalation or oral exposure are based on extrapolation from another route of

                                    -29-

-------
                                                                        FIGURE  2
                                               Example  Data  and References  for  Carcinogenicity
                                                         HEAST TABLE  3:  CARCINOGENICITY
                  EXPERIMEHT LENGTH
CHEMICAL ROUTE          SPECIES     TARGET               CANCER
DIMETHYLHYDRAZINE.1,2-      000077-78-1
        ORAL: DRINKING  LIFETIME
        WATER
                       MOUSE      CARDIOVASCULAR       TUMORS
                                  SYSTEM
        Inhalation [Slope] Conment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            [SLOPE FACTOR]
  [EPA     ORAL     INHALATION
GROUP]  (rag/kg/day)'(mg/kg/day)'
  B2
3.7E+1
3.7E+1
                                                                    January 1992
                         [UNIT RISK]
                        ORAL  INHALATION   REFERENCE
                        (ug/L) •' (ug/cu m)l
1.1E-3
LIE-2  009993
                                               REFERENCES FOR  HEAST TABLE 3:   CARCINOGENICITY
                                                                    January  1992
DIMETHYLHYDRAZINE,  1.2-                 000077-78-1
        009993 TOTH B AND  K PATEL.  1982. CARCINOGENICITY DOSE-RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF  1.2-DIMETHYLHYDRAZINE
               DI-HYDROCHLORIDE IN  MICE. I  LIGHT AND TRANSMISSION ELECTRON MICROSCOPIC STUDY OF COLONOIC NEOPLASMS.  AM. J. OF PATH.
               84:69-86.

               US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE)  WORK GROUP.
         IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254.  FTS 684-7254.

-------
exposure.  The route-to-route conversion required to present inhalation [slope factors]

in the units of mg/kg/day is considered by the CRAVE Work Group to be technically

incorrect. It is recommended that HEAST users who plan to use this information read a

further discussion of the difficulties inherent in this dose conversion which can be found

in Appendix A, Section II: Dose Conversions On HEAST.

    To estimate risk-specific concentrations in air from the [unit risk] in  air as presented

in Table 3, the specified level of risk is divided by the [unit risk] for air.  Hence, the air

concentration (in ug/m3) corresponding to an upper-bound increased lifetime cancer risk

of 1x10'5 is calculated as follows:
                        pg/m3 in air =
                                      [unit risk] in

    To estimate risk-specific concentrations in drinking water from the oral [slope factor]

values presented in Table 3, the specified level of risk is multiplied by 70 kg and divided

by the [slope factor] times 2 L/day.  Hence, the water concentration corresponding to an

upper-bound increased lifetime cancer risk of 1x10'5 is calculated as follows:
               mg/L in water = _ ^W  x 70 kg _
                              [slope factor] in (mglkglday)'^ x 2 L/day
                                      -31-

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          USER'S GUIDE:  RADIONUCLIDE CARCINOGENICITY



Introduction

    EPA classifies all radionuclides as Group A carcinogens. HEAST Table 4 lists

ingestion, inhalation and external exposure cancer slope factors for radionuclides in

units of picocuries (pCi).5 Ingestion and inhalation slope factors are central estimates in

a linear model of the age-averaged, lifetime attributable radiation cancer incidence

(fatal and nonfatal cancer) risk per unit of activity inhaled or ingested, expressed as

risk/pCi. External exposure slope factors are central estimates of lifetime attributable

radiation cancer incidence risk for each year of exposure to external radiation from

photon-emitting radionuclides distributed uniformly in a thick layer of soil, and are

expressed as risk/yr per pCi/gram soil. When combined with site-specific media

concentration data and appropriate exposure assumptions6, slope factors can be used

to estimate lifetime cancer risks to members of the general population due to

radionuclide exposures.
   5 Slope factors are reported in Table 4 in the customary units of picocuries (1 pCi - 10~12 curies (Ci) -
3.7xlO"2 nuclear transformations per second) for consistency with the system used for radionuclides in the IRIS
database. If required, slope factors hi Table 4 can be converted into the International System (SI) units of
becquerels (1 Bq = 1 nuclear transformation per second) by dividing each inhalation, ingestion, or external
exposure value by 27.03. Users can calculate cancer risks using slope factors expressed in either customary units
or SI units with equivalent results, provided that they also use air, water and soil concentration values in the
same system of units.

   6 Agency standardized default exposure scenarios and assumptions for use in baseline risk assessment
are provided in EPA (1991), Risk Assessment Guidance for Superfund, Vol. I,  Human Health Evaluation
Manual, Supplemental Guidance: "Standard Default Exposure Factors" (Interim Final),  Office of Emergency and
Remedial Response, OSWER Directive 9285.6-03. [NTIS order number:  PB 91-921314.]

                                          -32-

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 Intended Users and Applications

    HEAST users include individuals from the EPA, other Federal agencies, States and

 contractors who are responsible for the identification, characterization and remediation

 of sites contaminated with radioactive materials.  Radionuclide slope factors are

 calculated by EPA's Office of Radiation and Indoor Air (ORIA) to assist HEAST users

 with risk-related evaluations and decision-making at various stages of the remediation

 process.  During site assessment, for example, slope factors are used in EPA's Hazard

 Ranking  System (HRS) to assign toxicity factor values to radionuclides to calculate site

 scores. During the remedial investigation and feasibility study (RI/FS), slope factors are

 used to determine baseline site risk, to develop preliminary remediation goals, and to

 evaluate cleanup alternatives. For further examples on the application of radionuclide

 slope factors in risk evaluations, users are referred  to the following EPA documents:
      •     Hazard Ranking System (HRS), Federal Register (55 FR 515320),
            December 1990.

      •     Risk Assessment Guidance for Superfund; Volume I - Human Health
            Evaluation Manual (RAGS/HHEM), Part A, Baseline Risk Assessment
            (EPA/540/1-89/002).

      •     RAGS/HHEM Part B, Development of Risk-Based  Preliminary
            Remediation Goals (OSWER Directive 9285.7-01 B).  [NTIS order number:
            PB 92-963333.]

      •     RAGS/HHEM Part C, Risk Evaluation of Remedial Alternatives (OSWER
            Directive 9285.7-01 C). [NTIS order number: PB 92-963334.]


      Copies of RAGS/HHEM Parts A, B and C are available to the public from the

National Technical Information Service (NTIS) at (703) 487-4650.  Copies are  available

to EPA staff by calling the Superfund Documents Center at (703) 603-8917.
                                     -33-

-------
Radiation Effects
Ionizing radiation has been shown to be a carcinogen, a mutagen, and a
teratogen. Radiation can induce cancers in nearly any tissue or organ in both humans
and animals, and the probability of cancer induction increases with increasing radiation
dose. Cancer induction is a delayed response that has been documented extensively
in epidemiological studies of Japanese atomic bomb survivors, underground uranium
miners, radium dial painters, and patients subject to a variety of radiation treatments.
Laboratory animal research and mammalian tissue culture studies have provided
additional, collaborative data.

Mutagenic effects of radiation have been demonstrated primarily in animal and
tissue culture studies; limited data from studies of A-bomb survivors indicate that
humans may be as sensitive or less sensitive than animals to radiogenic mutagenicity.
Data are also available from both human and animal studies on the teratogenic effects
of radiation. These data show that the fetus is most sensitive to radiation injury during
the early stages of organ development (between 8 and 15 weeks for the human fetus).
Resultant radiation-induced malformations depend on which cells are most actively
differentiating at the time of exposure.

EPA classifies all radionuclides as Group A carcinogens, based on their property
of emitting ionizing radiation and on the extensive weight of evidence provided by
epidemiological studies of radiogenic cancers in humans. At Superfund radiation sites,
EPA generally evaluates potential human health risks based on the radiotoxicity, i.e.,
adverse health effects caused by ionizing radiation, rather than on the chemical toxicity,
of each radionuclide present. These evaluations consider the carcinogenic effects of
radionuclides only. In most cases, cancer risks are limiting, exceeding both mutagenic
and teratogenic risks.
-34-

-------
Derivation of Radionuclide Slope Factors
EPA's Office of Radiation and Indoor Air (ORIA) calculates radionuclide slope
factor values using health effects data and dose and risk models from a number of
national and international scientific advisory commissions and organizations, including
the National Academy of Sciences (NAS), the National Council on Radiation Protection
and Measurements (NCRP), the United Nations Scientific Committee on the Effects of
Atomic Radiation (UNSCEAR), and the International Commission on Radiological
Protection (ICRP). A detailed discussion of ORIA's approach and assumptions is
provided in Estimating Radiogenic Cancer Risks (EPA 402-R-93-076).

Radionuclide slope factors are calculated for each radionuclide individually,
based on its unique chemical, metabolic and radioactive properties. The calculation
uses dose estimates from EPA's computer code RADRISK7, vital statistics from the
L/.S. Decennial Life Tables for 1979-1981 (described in EPA 402-R-93-076), and
cancer risk estimates based largely on the results of the NAS BEIR V report8, ICRP
Publication 609, and U.S. Nuclear Regulatory Commission (NRC) analyses.10 Ingestion
and inhalation slope factors for radionuclides account for:

• the amount of radionuclide transported into the bloodstream from either
the gastrointestinal (Gl) tract following ingestion, or from the lungs
following inhalation;
• the ingrowth and decay of radioactive progeny produced
within the body subsequent to intake;
7 Dunning, D.E. Jr., Leggett, R.W., and Yalcinatas, M.G. (1980). "A Combined Methodology for Estimating
Dose Rates and Health Effects from Exposure to Radioactive Pollutants," ORNL/TM-7105.
BFTR vatrDal A«ademy ,? Rd?CeS V???' Health Effects of Exposure to I,ow levels of
PfelK v» Committee on the Biological Effects of Ionizing Radiations, National Research Council, Washington,

'International Commission on Radiological Protection (1991), 1990 Recommendations of the
Commission on Radiological Protection. ICRP Publication 60, Pergamon Press, New York, NY.
m U.S^ Nuclear Regulatory Commission (1991, 1993), Health Effects Models for Nuclear Power Plant
Accent Consequence Analysis, NUREG/CR-4214. Addenda documenting the scientific basis for radiogenic
risk models published in 1991 (for low-LET radiation) and 1993 (for alpha radiation). See EPA 402-R-93-076
for discussion of these models.

-35-

-------
      •      the distribution and retention of each radionuclide (and its associated
             progeny, if appropriate) in body tissues and organs;
      •      the radiation dose delivered to body tissues and organs from the
             radionuclide (and its associated progeny, if appropriate); and
      •      the sex, age, and organ-specific risk factors over the lifetime of exposure.

      The slope factors are the average risk per unit intake or exposure for an
individual in a stationary population with vital statistics (mortality rates) of the United
States in 1980. (The expected lifetime for an individual in this population is about 74
years.)  Consequently, radionuclide ingestion and inhalation slope factors are DQJ
expressed as a function of body weight and time, and do QOJ require corrections for Gl
absorption or lung transfer efficiencies.
  NOTE:  The GI absorption values (fj, ICEP lung classifications (D, W, Y) and radioactive half-
  Uves are provided in HEAST Table 4 for reference only and should not be used to correct,
  modify, or in any way adjust radionuclide slope factors or intake assumptions in risk calculations.
       External slope factors provide cancer risk estimates per unit exposure to a
uniform radionuclide concentration in soil.  These factors, which account for photon
energy flux attenuation and buildup in soil, are calculated for each radionuclide using
volume and surface dose factors derived using the computer code DFSOIL11

       Because of the radiation risk models employed for both internal and external
exposures, slope factors for radionuclides  are characterized as central estimates in a
linear model of the age-averaged lifetime total radiation cancer incidence risk per unit
intake or exposure.
    11 Sjoreen, A.L., Kocher, D.C., Kfflough, G.G. and Miller C.W. (1984). "MLSOIL and DFSOIL - Computer
Codes to Estimate Effective Ground Surface Concentrations for Dose Computations," Oak Ridge National
Laboratory, Oak Ridge, TN, ORNL-5974.
                                        -36-

-------
 About the Information Provided in Table 4
       Table 4 lists ingestion, inhalation and external exposure slope factors of principal
 radionuclides, and provides key parameter values used in the derivation of slope factor
 values. Radionuclides are presented alphabetically by element and atomic weight.

       Selected  radionuclides and radioactive decay chain products are designated in
 HEAST Table 4 with the suffix "+D" (e.g., U-238+D,  Ra-226+D, Cs-137+D) to indicate
 that cancer risk estimates for these radionuclides include the contributions from their
 short-lived decay products, assuming equal activity concentrations (i.e., secular
 equilibrium) with the principal or parent nuclide in the environment.12  Decay chains are
 identified  in Exhibit 1.

       In most cases, site-specific analytical data should be used to establish the actual
 degree of equilibrium between each parent radionuclide and its decay products in each
 media sampled. However, in the  absence of empirical data, the "+D" values for
 radionuclides should be used unless  there are compelling reasons not to.  For example,
 the external slope factors for Cs-137  and  Cs-137+D are 0.0 and 2x10"6 (risk per year
 per pCi/gram), respectively. The value for Cs-137+D is higher because it includes the
 risk contribution from cesium's short-lived gamma-emitting decay product Ba-137m
 (half-life, 25.5 minutes) which, under  most environmental conditions, will be in secular
 equilibrium with Cs-137.

       Note that there may be circumstances, such as long disposal times or
 technologically enhanced concentrations of naturally occurring radionuclides, that may
 necessitate the combination of the risks of a parent radionuclide and its decay products
 over several contiguous subchains. For example, Ra-226 soil analyses at a site might
 show that all radium decay products are present in secular equilibrium down to stable
 Pb-206 (See Exhibit 1). In this case, Ra-226 risk calculations should be based on the
   12 There is one exception to the assumption of secular equilibrium. For the inhalation slope factor for Rn-
222+D reported in HEAST Table 4, ORIA assumes a 50% equilibrium value for radon decay products (Po-218,
Pb-214, Bi-214 and Po-214) in air.

                                       -37-

-------
ingestion, inhalation and external exposure slope factors for the Ra-226+D subchain,
plus the ingestion, inhalation and external exposure factors for the Pb-210+D subchain.
For actual sites, users should consult with a health physicist or  radiochemist (1) to
evaluate the site-specific analytical data to determine the degree of equilibrium between
parent radionuclides and decay members of contiguous decay chains and (2) to assist
in the combination of appropriate slope factor values.  For health physics and
radioanalytical support,  HEAST users may contact EPA's Regional Radiation Program
Managers, ORIA's National Air and Radiation Laboratory (NAREL) in Montgomery,
Alabama, ORIA's Las Vegas Laboratory (ORIA-LV) in Las Vegas, Nevada, or the ORIA
contact at EPA headquarters in Washington, D.C., listed in Exhibit 2.

      A Chemical Abstract System Reference Number (CASRN) is assigned to each
radionuclide for identification and reporting accuracy during risk assessments, and
radioactive half-lives are provided for reference.

      The designations "D", "W", and "Y" presented in Table 4 under the heading
"ICRP Lung  Class" in the tables refer to the lung clearance times for inhaled particulate
radionuclides, expressed as days (D), weeks (W), or years (Y), as recommended by the
International Commission on  Radiological Protection (ICRP). Gaseous radionuclides,
e.g., Rn-222, are designated  with an asterisk ("*"). "Gl Absorption Factors, f/' are the
fractional amounts of each radionuclide that may be absorbed from the gastrointestinal
(Gl) tract into blood following an oral intake. The ICRP lung clearance classifications
and Gl absorption factors provided in Table 4 are the default values that EPA used to
calculate radionuclide slope factors for inhalation and ingestion exposures, respectively.
These factors are provided for reference only (see the Note Box).

Where to Address Questions About Radionuclide Slope Factors:
      EPA continuously reviews the scientific literature on radiation effects to ensure
that the Agency's risk assessment methodologies are consistent with current models
                                      -38-

-------
and assumptions. As risk methodologies are refined, EPA will revise and update the
slope factors in Table 4.

      HEAST users with questions about radionuclide slope factor values and their use
in radiation risk assessments should contact Michael Boyd of the Remedial Guidance
Section of the Radiation Assessment Branch of ORIA at (202) 233-9395. Written
requests for assistance can be sent by fax to (202) 233-9650.
                                    -39-

-------
Exhibit 1.  Radionuclide Decay Chains Considered Explicitly in HEAST Table 4*
Principal Radionuclide*
Nuclide
Ac-227+D
Ag-108m+D
Ag-llOm+D
Am-243+D
Ce-144+D
Cs-137+D
Np-237+D
Pb-210+D
Pu-241+D
Pu-244+D
Ra-226+D
Ra-228+D
Ru-106+D
Sb-125+D
Sr-90+D
Half-life
(yr)
22
127
0.7
7.4 x 103
0.8
30
2.1 x 10*
22
14
8.3 x 107
1.6 x 103
8
1
3
29
Associated Decay Chain*
[Th-227 (98.6%, 19 d)]
Fr-223 (1.4%, 22 min)
Ra-223 (11 d)
Rn-219 (4 s)
Pc-215 (2 ms)
Pb-211 (36 min)
Bi-211 (2 min)
[Tl-207 (99.7%, 5 min)
Po-211 (0.3%, 0.5s)]
_d
Ag-108 (9%, 2 min)
Ag-1 10(1%, 25s)
Np-239 (2 d)
[Pr-144 (9%, 17 min)
Pr-144m (2%, 7 min)]
Ba-137m (95%, 3 min)
Pa-233 (27 d)
Bi-210 (5 d)
Po-210 (138 d)
[Am-241 (~100%, 432 y)
U-237 (7 d)]e
U-240 (~100%, 14 h)
Np-240
Rn-222 (4 d)
Po-218 (3 min)
Pb-214 ("100%, 27 min)
Bi-214 (20 min)
Po-214 (~100%, 1 min)
Ac-228 (6 h)
Rh-106 (30 s)
Te-125m (23%, 58 d)
Y-90 (64 h)
Terminal Nuclide or
Radionuclide0
Nuclide
Pb-207
Pd-108 (91%)
[Cd-108 (98%)
Pd-108 (2%)]
Cd-110(99%)
[Cd- 110 (99.7%)
Pd- 110 (0.3%)
Pu-239
Nd-144
Ba-137
U-233
Pb-206
Np-237
Pu-240
Pb-210
Th-228
Pd-106
Te-125
Zr-90
Half-life
(yr)
*
*
*
*
*
*
*
2.4 x 104
*
*
' 1.6 x 105
*
2.1 x 106
6.5 x 103
22
2
*
*
*
                                  -40-

-------
                                     Exhibit  1  (Continued)
Principal Radionuclide"
Nuclide
Th-228+D
Th-229+D
U-235+D
U-238+D
Half-life
(yr)
2
7.3 x 103
7.0 x 108
4.5 x 109
Associated Decay Chaink
Ra-224 (4 d)
Rn-220 (56 s)
Po-216 (0.2 s)
Pb-212 11 h)
Bi-212 (61 min)
[Po-212 (64%, 0.3 us)
Tl-208 (36%, 3 min)]
Ra-225 (15 d)
Ac-225 (10 d)
Fr-221 (5 min)
At-217(32ms)
Bi-213 (46 min)
[Po-213 (98%, 4 MS)
Tl-209 (2%, 2 min)]
Pd-209 (3 h)
Th-231 (26 h)
Th-234 (24 d)
[Pa-234m (99.8%, 1 min)
Pa-234 (0.2%, 7 h)]
Terminal Nuclide or
Radionuclide'
Nuclide
Pb-208
Bi-209
Pa-231
U-234
Half-life
(yr)
*
*
3.4 x 10*
2.4 x 105
   Radionuclides with half-lives greater than six months. "+D" designates principal radionuclides with
   associated decay chains.
   The chain of decay products of a principal radionuclide extending to (but not including) the next principal
   radionuclide or a stable radionuclide. Half-lives are given in parentheses. Branches are indicated by
   square brackets with branching ratios in parentheses.
   The principal radionuclide or stable nuclide that terminates an associated decay chain.  Stable nuclides are
   indicated by an asterisk (*) in place of a half-life.
   A hyphen indicates that there are no associated decay products.
   The branching decay for Pu-241 and Cm-243 involves multiple principal radionuclides and associated
   radionuclides.
*  Table adapted from:  C. Yu, et al. (1994), "Manual for Implementing Residual Radioactive Materials
   Guidelines Using RESRAD, Version 5.0," Argonne National Laboratory.
                                              -41-

-------
Exhibit 2. EPA Radiation Program Staff
TomD'Avanzo (617)565-4502
Radiation Program Manager, Region 1
U.S. Environmental Protection Agency
John F. Kennedy Federal Building/ATR
One Congress Street
Boston, MA 02203

Paul A. Giardina (212) 264-4110
Radiation Program Manager, Region 2
U.S. Environmental Protection Agency/lOOSA
26 Federal Plaza
New York, NY 10278

Lewis Felleisen (215) 597-8326
Radiation Program Manager, Region 3
Special Program Section (3ATI 2)
U.S. Environmental Protection Agency
841 Chestnut Street
Philadelphia, PA 19107

Paul Wagner (404) 347-3907
Radiation Program Manager, Region 4
U.S. Environmental Protection Agency
345 Courtland Street, NE
Atlanta, GA 30365

JackBarnette (312)886-6175
Radiation Program Manager, Region 5
U.S. Environmental Protection Agency
77 West Jackson Boulevard/ATI 8J
Chicago, IL 60604-3507

Donna Ascenzi (214) 655-7224
Radiation Program Manger, Region 6
U.S. Environmental Protection Agency
Air Enforcement Branch (6T-E)
1445 Ross Avenue
Dallas, TX 75202-2733

Robert Dye (913)551-7605
Radiation Program Manager, Region 7
U.S. Environmental Protection Agency
726 Minnesota Avenue/ARTXARBR
Kansas City, KS 66101
-42-

-------
                                   Exhibit 2 (Continued)
Milton W. Lammering                                                          (303) 293-1440
Radiation Program Manager, Region 8
(8HWM-RP)
U.S. Environmental Protection Agency
Suite 500
999 18th Street
Denver, CO 80202-2405

Michael S. Bandrowski                                                         (415) 744-1048
Radiation Program Manager, Region 9
(Al-1)
U.S. Environmental Protection Agency
75 Hawthorne Street
San Francisco, CA 94105

Jerry Leitch                                                                   (206) 442-7660
Radiation Program Manager, Region 10
(AT-082)
U.S. Environmental Protection Agency
1200 Sixth Avenue
Seattle, WA 98101

Samuel T. Windham, Director                                                   (205) 270-3402
Office of Radiation and Indoor Air
National Air and Radiation Environmental Laboratory (NAREL)
U.S. Environmental Protection Agency
540 South Morris Avenue
Montgomery, AL 36115-2601

Jed Harrison, Director                                                          (702) 798-2476
Office of Radiation and Indoor Air
Las Vegas Laboratory
EPA Facilities
P.O. Box 98516
Las Vegas, NV 89193-8516

Michael Boyd                                                                 (202) 233-9395
Office of Radiation and Indoor Air (6603 J)
U.S. Environmental Protection Agency
401 M Street, SW
Washington, DC 20460
                                           -43-

-------
I^TOE
CHEMICAL DOSE
LEVEL ROUTE
GLYCIDALDEHYDE
NOAEL 10 PPM
INHALATION:
INTERMITTENT
Example Data and References for Chemical Toxicity
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SPECIES
EXPERIMENT LENGTH TARGET
000765-34-4
RAT
12 WEEKS WHOLE BODY
BLOOD
KIDNEY
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ma/cu M) (inq/lcQ/dav) (na/ai •) (jM/ka/dav)
UF UF UF UF
1E-2 4E-3 1E-3 IRIS
DECREASED WEIGHT GAIN 300 300 3000
HEMATOPOIETIC EFFECTS
EFFECTS
005968
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: ALSO SEE TABLE 3: CARCINOGENICITY.
January 1992
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
GLYCIDALDEHYDE 000765-34-4
005968 HINE CH. RJ GUZMAN. MK DUNLAP. R LIMA AND GS LOQUVAM. 1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH ENVIRON HEALTH
2: 23-30.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. National Center for Environmental Assessment. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC.

-------
                                                                         FIGURE  2
                                                Example  Data and References  for  Carcinogenicity
                                                         HEAST TABLE  3:  CARCINOGENICITY
                  EXPERIMENT LENGTH
CHEMICAL ROUTE          SPECIES     TARGET               CANCER
DIMETHYLHYDRAZINE.1.2-      000077-78-1
        ORAL: DRINKING  LIFETIME
        WATER
                       MOUSE      CARDIOVASCULAR       TUMORS
                                  SYSTEM
        Inhalation [Slope] Coument:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            [SLOPE FACTOR]
  [EPA     ORAL     INHALATION
GROUP]  (mg/kg/day) '(ing/kg/day)'
 B2
3.7E+1
3.7E+1
                                                                    January 1992
                          [UNIT RISK]
                        ORAL  INHALATION   REFERENCE
                        (ug/L)'1 (ug/cu •)•'
1.1E-3
1.1E-2  009993
                                               REFERENCES  FOR HEAST TABLE 3:   CARCINOGENICITY
                                                                    January  1992
DIMETHYLHYDRAZINE.  1.2-                 000077-78-1
        009993  TOTH B AND K PATEL.  1982. CARCINOGENICITY DOSE-RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF 1.2-DIMETHYLHYDRAZINE
               DI-HYDROCHLORIDE IN  MICE. I. LIGHT AND TRANSMISSION  ELECTRON MICROSCOPIC STUDY OF COLONOIC NEOPLASMS. AM. J. OF PATH.
               84:69-86.

               US EPA.  1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
        IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513)  569-7254.  FTS 684-7254.

-------
                                  HEAST  TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                             May 1995
 CHEMICAL     BQSI          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
 ACENAPHTHENE
     NOAEL 175 MG/KG/DAY        MOUSE
              ORAL: GAVAGE      90  DAYS
              TARGET

       000083-32-9

             LIVER
CRITICAL  EFFECT
                                                            HEPATOTOXICITY
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
(mg/cu m)  (mq/ka/dav)   (ma/cu m)  (mg/ka/dav)
   UF         UF          UF         UF
                                                                                                      6E-1
                                                                                                      300
                                                                                            IRIS
                                                                          010165
ACENAPTHYLENE                      000208-96-8
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                     005202
ACEPHATE
     LOAEL 2 PPM
             ORAL: DIET
       030560-19-1
RAT
13 WEEKS
                                            BRAIN
 DECREASED CHOLINESTERASE
 ACTIVITY
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      4E-3
                                                                                                      30
                                                                                            IRIS
                                           005833
ACETONE
     NOEL  100 MG/KG/DAY
             ORAL: GAVAGE
       000067-64-1
RAT
90 DAYS
LIVER
KIDNEY
KIDNEY
INCREASED WEIGHT
INCREASED WEIGHT
NEPHROTOXICITY
                                                                                                      1E+0
                                                                                                      100
                                                                                            IRIS
                                                                          005204
ACETONE  CYANOHYDRIN   / (2-METHYLLACTONITRILE)
     NOAEL 8.75 MG/CKG-DAY)     RAT
             ORAL: GAVAGE     90 DAYS      LIVER
                                     000075-86-5

                             INCREASED RELATIVE WEIGHT
                                                                                                     8E-3
                                                                                                     300
                                                                                            8E-4
                                                                                            3000
                                                                          005776
            SUBCHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE  2: ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfC]  COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS --  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-1

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL    DOSE           SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
              TARGET
CRITICAL EFFECT
          Subchronic
  [RfC]      [RfD]
(mQ/cu m)  (ma/kg/day)
   UF         UF
      Chronic
 [RfC]        [RfD]
(mo/cu in)  (ma/ka/dav)
   UF        UF
                                                                                                                                         REFERENCE
ACETONITRILE
     NOAEL 100 PPM
              INHALATION:
              INTERMITTENT
       000075-05-8
 MOUSE
92 DAYS       ERYTHROCYTES
              BLOOD
              LIVER
 DECREASED CELL  COUNT
 DECREASED HEMATOCRIT
 HEPATIC LESIONS
            6E-2
            300
                                                                 IRIS
                                            005210
             SUBCHRONIC [RfC] COMMENT-  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
             SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE  EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
             CHRONIC [RfC] COMMENT-  ALSO SEE HEAST TABLE 2: ALTERNATE  METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
             CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.  UNDER REVIEW. CURRENT NUMBER SUBJECT TO
                                     CHANGE.
ACETOPHENONE
     NOAEL 10.000 PPM
              ORAL: DIET
        000098-86-2
 RAT
17 WEEKS
 NONE OBSERVED
            1E+0
            300
                                                                  IRIS
             CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP.
                     005212


                     010874
 ACROLEIN                             000107-02-8
     NOAEL 15.6 MG/KG/DAY       RAT
              ORAL:  WATER      90 DAYS

             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                               2E-2
                                                                                               1000
                                                                                                                   IRIS
                                                                             010390
                                                                                                         010856
 IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                    1-2

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
 CHEMICAL     DQS£          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT
ACRYLAHIDE                          000079-06-1
     NOEL  0.2 MG/KG/DAY        RAT
              ORAL:  DRINKING    90 DAYS      NERVE            DAMAGE
              WATER

            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                      Subchronic          Chronic
                                                               [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                                             (IT»/CU m) (iro/kci/dav)   (ma/cu m)  (ma/kq/dav)
                                                               UF         UF           UF        UF
                                                                        2E-3
                                                                        100
                                                                IRIS       005835
                                                                                                                 IRIS
             CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (09/20/90) BY THE RfD/RfC WORK GROUP.
                                                                                                        010876
ACRYLIC ACID
     NOAEL 53 MG/KG/DAY
             ORAL: DRINKING
             WATER
       000079-10-7
 RAT
2 GENERATION  WHOLE BODY
                                           5E-1
                                           100
                                                DECREASED PUP WEIGHT


SUBCHRONIC [RfD] COMMENT:  THE CHRONIC  ORAL RfD ON IRIS WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                                              IRIS
005836
     LOAEL 5 PPM               MOUSE
              INHALATION:       13 WEEKS
              INTERMITTENT
             NASAL MUCOSA     LESIONS
                                3E-3
                                100
ACRYLONITRILE
     NOAEL 1 MG/CKG-DAY)        MOUSE
             ORAL: GAVAGE      60 DAYS
       000107-13-1

             TESTES
             TESTES
DECREASED SPERM COUNTS
SEMINIFEROUS  TUBULE
DEGENERATION
                                                                                                       1E-2
                                                                                                       100
                                                                                                      IRIS
                                                                                                                1E-3
                                                                                                                1000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD]  UNDER REVIEW BY THE RfD/RfC WORK  GROUP WAS MODIFIED TO ESTIMATE THE
                        SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY
010346
010939
ADIPONITRILE                        000111-69-3
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                        005157
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                    1-3

-------
                                  HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN  CARCIN06ENICITY)
                                                                                                               May 1995
CHEMICAL    DOSE           SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
                                                              [RfC]
                                          Subchronic
                                            [RfD]
                              Chronic
                        [RfC]       [RfD]
                                                                                                                                         REFERENCE
              TARGET
CRITICAL EFFECT
(mq/cu m)  (ma/kg/dav)   (ma/cu m) (mo/ka/dav)
                                                                                              UF
                                                                          UF
                                                          UF
                                     UF
ALACHLOR
     NOEL  1  MG/KG/DAY
             ORAL: CAPSULE
       015972-60-8
DOG
1  YEAR       BLOOD           ANEMIA
             SITES. MULTIPLE  HEMOSIDEROSIS
                                            1E-2
                                            100
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
ALDICARB
     NOAEL 0.01  MG/KG-DAY       HUMAN
             ORAL              ACUTE
       000116-06-3
             CENTRAL NERVOUS  SWEATING
             SYSTEM
                                            1E-3
                                            10
                                 IRIS
005837
                                                                                              IRIS
                                            010960
            SUBCHRONIC [RfD] COMMENT:. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
            GENERAL COMMENT:  CLINICAL SIGNS OF ACETYL CHOLINESTERASE  INHIBITION INCLUDING SWEATING. PINPOINT PUPILS. LEG WEAKNESS.  NAUSEA. DIARRHEA
                               AND OTHER EFFECTS WERE OBSERVED IN THE PRINCIPAL AND SUPPORTING STUDIES.
ALORIN                               000309-00-2
     LOAEL 0.025 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS      LIVER
                              LESIONS
                                            3E-5
                                            1000
                                  IRIS
                                                                                                         005159
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ALLIDOCHLOR                         000093-71-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                         005838
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                    1-4

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                            May 1995
 OEtlKAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 ALLYL ALCOHOL                      000107-18-6
     NOEL  50 PPM              RAT
             ORAL: DRINKING    15 WEEKS     LIVER
             WATER                         KIDNEY
                                              CRITICAL EFFECT
                             EFFECTS
                             EFFECTS
          Subchronic          Chronic
  [RfC]      [RfD]        [RfC]       [RfD]     REFERENCE
(HM/CU m)  (ma/ko/dav)   (ma/cu m) (ma/ko/dav)
   UF         UF          UF        UF
                                                                                        5E-2
                                                                                        100
                                IRIS
005839
 ALLYL  CHLORIDE
     NOAEL 17 MG/CU M
              INHALATION:
              INTERMITTENT
       000107-05-1
 RABBIT
5 MONTHS
                               NERVOUS  SYSTEM   NEUROTOXICITY


GENERAL COMMENT:  ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
                                                            1E-2
                                                            300
                      IRIS
010369
ALUMINUM                            007429-90-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                    005162
ALUMINUM PHOSPHIDE
     NOAEL 0.43 MG/KG/DAY       RAT
             ORAL: DIET       2 YEARS
       020859-73-8

             WHOLE BODY
             UNSPECIFIED
                                               ALTERED WEIGHT
                                               ALTERED CLINICAL PARAMETERS
                                                                                                     4E-4
                                                                                                     100
                                IRIS
010255
AHETRYN
     NOEL  10 MG/KG/DAY
             ORAL: GAVAGE
       000834-12-8
 RAT
13 WEEKS
                               LIVER
                                                           EFFECTS
AMINO-2-NAPHTHOL. 1-              002834-92-6
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                     9E-2
                                                                                                     100
                                                                                           IRIS
                                                                                                                       005841
                                                                                                                                    005842
AMINO-2-NAPHTOL HYDROCHLORIDE.  1-      001198-27-2
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                    005843
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                1-5

-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DQS1 SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfO]
(IHQ/CU in) (ma/ka/dav)
UF UF
Chronic
[RfC] [RfD]
(mq/cu m) (ma/kg/dav)
UF UF
REFERENCE
AMINOPHENOL. M-
NOAEL 1300 PPM
ORAL: DIET
000591-27-5
RAT
13 WEEKS WHOLE BODY
THYROID
ALTERED WEIGHT
ALTERED WEIGHT
7E-1
100
7E-2
1000
005844
AMINOPHENOL. 0- 000095-55-6
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005845
AMINOPHENOL. P- 000123-30-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005846
AMINOPYRIDINE. 4-
NOAEL 3 PPM
ORAL: DIET
AMMONIA
NOAEL 34 MG/L
ORAL: DRINKING
WATER
000504-24-5
RAT
90 DAYS LIVER
BRAIN
007664-41-7
HUMAN
SENSORY
INCREASED WEIGHT
INCREASED WEIGHT
TASTE THRESHOLD
2E-4
1000
34 MG/L
1
2E-5
10000
34 MG/L
1
SUBCHRONIC [RfD] COMMENT: GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD.
SAFE CONCENTRATION MAY BE HIGHER. BUT DATA ARE INADEQUATE TO ASSESS.
CHRONIC [RfD] COMMENT: GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD.
SAFE CONCENTRATION MAY BE HIGHER. BUT DATA ARE INADEQUATE TO ASSESS
NOAEL 6.4 MG/CU M
INHALATION:
INTERMITTENT
HUMAN
NASAL CAVITY
LUNGS
LUNGS
RHINITIS
PNEUMONIA
LESIONS
1E-1
30
IRIS
005847
005166
010392
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-6

-------
                                   HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGEN1CITY)
 CHEMICAL
 LEVEL
COSE          SPECIES
ROUTE    EXPERIMENT LENGTH
                                              TARGET
 ANILINE
      NOAEL 19 MG/CU M
               INHALATION:
               INTERMITTENT
                          000062-53-3
                   MOUSE
                  20-26 WEEKS   SPLEEN
                                RAT
                                20-26 WEEKS

                                GUINEA PIG
                                20-26 WEEKS
                               SPLEEN
                               SPLEEN
                CRITICAL EFFECT




                 PATHOLOGY


                 PATHOLOGY


                 PATHOLOGY
          Subchronic
  [RfC]      [RfD]
(mq/cu m)  (ina/ka/dav)
   UF          UF
                                                                                1E-2
                                                                                300
       Chronic
 [RfC]        [RfD]
(mq/cu  m)  (mg/ka/dav)
   UF        UF
                                                                                                  May 1995


                                                                                             REFERENCE
                      IRIS
                     010370
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
 ANTHRACENE
      NOEL  1000 MG/KG/OAY       MOUSE
              ORAL:  GAVAGE      90 DAYS
                         000120-12-7
                                                             NONE OBSERVED                              3E+0                  IRIS
                                                                                                        300

             CHRONIC [RfC] COMMENT:  THE CHRONIC  INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94)  BY  THE RfD/RfC WORK GROUP.
ANTIMONY PENTOXIDE
     LOAEL 0.46 MG/KG/DAY
              ORAL: DRINKING
              WATER
                         001314-60-9
                  RAT
                 LIFETIME
WHOLE BODY
BLOOD
                                               INCREASED MORTALITY
                                               ALTERED CHEMISTRIES
           5E-4
           1000
         5E-4
         1000
010166


010964




005174
             SUBCHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT
             CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO ANTIMONY  BY CORRECTING FOR DIFFERENCES IN  MOLECULAR WEIGHT.
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                     1-7

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                 May 1995
CHEMICAL
LEVEL
ROUTE
                          SPECIES
                     EXPERIMENT LENGTH
                                TARGET
CRITICAL EFFECT
          Subchronic
  [RfC]      [RfD]
(mg/cu m)  (ma/ka/dav)
   UF         UF
      Chronic
 [RfC]        [RfD]
(mo/cu m)  (ma/kq/dav)
   UF        UF
                                                                                                                                         REFERENCE
ANTIMONY  POTASSIUM  TARTRATE      000304-61-0
     LOAEL  0.91 MG/KG/DAY       RAT
             ORAL: DRINKING    LIFETIME      WHOLE BODY
             WATER                          BLOOD
                                                INCREASED MORTALITY
                                                ALTERED CHEMISTRIES
                                                                                                       9E-4
                                                                                                       1000
                                                                 9E-4
                                                                 1000
                                                                                                                           005234
            SUBCHRONIC [RfD] COMMENT-  CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
            CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY  TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ANTIMONY TETROXIDE
     LOAEL 0.44 MG/KG/DAY
             ORAL: DRINKING
             WATER
                          001332-81-6
                   RAT
                   LIFETIME
                                            WHOLE BODY
                                            BLOOD
  INCREASED MORTALITY
  ALTERED CHEMISTRIES
            4E-4
            1000
          4E-4
          1000
                                                                                                                                       005238
             SUBCHRONIC [RfD] COMMENT-   CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
             CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO ANTIMONY  BY CORRECTING FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
 ANTIMONY TRIOXIDE
     LOAEL 0.42 MG/KG/DAY
              ORAL:  DRINKING
              WATER
                          001309-64-4
                   RAT
                   LIFETIME
                                             WHOLE BODY
                                             BLOOD
  INCREASED MORTALITY
  ALTERED CHEMISTRIES
             4E-4
             1000
           4E-4
           1000
                                                                                                                                        005242
             SUBCHRONIC  [RfD] COMMENT-  CALCULATED BY ANALOGY TO ANTIMONY BY  CORRECTING FOR DIFFERENCES IN  MOLECULAR WEIGHT.
             CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
 ANTIMONY.  METALLIC
      LOAEL 0.35 MG SB/KG/DAY
              ORAL:  DRINKING
              WATER
                           007440-36-0
                    RAT
                   LIFETIME
                                             WHOLE BODY
                                             BLOOD
  INCREASED MORTALITY
  ALTERED CHEMISTRIES
             4E-4
             1000
                                                                                                                             IRIS
                                                                             005170
 IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RIS£ INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                   1-8

-------
                                   HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
 CHEMICAL     CQSI          SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
 ARAMITE
      NQAEL 100 PPM
              ORAL: DIET
      NOAEL 500  PPM
              ORAL:  DIET
       000140-57-8
 RAT
104 WEEKS     LIVER
 DOG
52 WEEKS
                                                            CRITICAL EFFECT
                                                             INCREASED WEIGHT
                                                               Subchronic          Chronic
                                                       [RfC]      [RfD]        [RfC]        [RfD]     REFERENCE
                                                      (mq/cu m) (mq/ka/dav)   (mg/cu m)  (ma/ka/dav)
                                                        UF         UF          UF         UF
                                             LIVER            DEGENERATION


             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                        1E-1
                                                                        100
 AROCLOR  1248                      012672-29-6

             CHRONIC RfD COMMENT:  THE CHRONIC ORAL RfD IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP
 AROCLOR 1254
      LOAEL 0.005 MG/KG/DAY
              ORAL:  CAPSULE     MONKEY
                               >5 YEARS
      011097-69-1

             IMMUNE SYSTEM    TOXICITY
                                                                       5E-5
                                                                       100
             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE  THE SUBCHRONIC ORAL [RfD].
ARSENIC.  INORGANIC
     NOAEL 0.009 MG/L
             ORAL
HUMAN
007440-38-2

      SKIN
      SKIN
                                                            KERATOSIS
                                                            HYPERPIGMENTATION
                                                                       3E-
                                                                       3
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                                             5E-2
                                                                                                                             100
                                                                                             IRIS
                                                                                                        005850
                                                                                                 005849
                                                                                                                                       010940
                                                                                      IRIS       010963
IRIS       010434
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                  1-9

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May  1995
CHEMICAL    CQSt          SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
             TARGET
ATRAZINE
     NOEL  3.5 MG/KG/DAY        RAT
             ORAL: DIET        2  YEARS
       001912-24-9

             WHOLE BODY
                                              CRITICAL EFFECT
                                               DECREASED WEIGHT GAIN
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]    REFERENCE
(ma/cu m)  (ma/ka/dav)   (ma/cu m) (ma/ka/dav)
   UF         UF           UF         UF
            3.5E-2
            100
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
BARIUM                               007440-39-3
     NOAEL 0.21 MG/KG/DAY        HUMAN
             ORAL: WATER       10 WEEKS
             CARDIOVASCULAR   INCREASED BLOOD PRESSURE
             SYSTEM
                                                                                          7E-2
                                                                                          3
                                                                                                               IRIS
                                            010855
                                                                                             IRIS
                                                                                                                          010348
             SUBCHRONIC [RfC] COMMENT-   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
             SUBCHRONIC [RfD] COMMENT-   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
             CHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
 BARIUH CYANIDE                      000542-62-1
             CHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/20/93)  BY THE RfD/RfC WORK GROUP.
                                                                                                        010941
 BENEFIN
      NOAEL 25 MG/KG/DAY
              ORAL:  DIET
       001861-40-1
DOG
1  YEAR
                                ERYTHROCYTE      DECREASED COUNT


SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
             3E-1
             100
                                                                                                                IRIS
                                             005852
 BENZAL CHLORIDE                    000098-87-3
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                        005853
 IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                  1-10

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                 May 1995
             DOSE          SPECIES
LEVEL        ROUTE    EXPERIMENT LENGTH       TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(ma/cu in)  (md/ka/dav)   (ma/cu m)  (mg/ka/dav)
   UF          UF           UF        UF
         BENZALDEHYDE                       000100-52-7
     NOEL  200 MG/KG/DAY        RAT
              ORAL: GAVAGE      13 WEEKS      KIDNEY          EFFECTS
                                            FORESTOMACH     LESIONS
                                           1E+0
                                           100
             SUBCHRONIC [RfD] CPMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].

BENZALDEHYDE  CYANOHYDRIN         000532-28-5
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                 IRIS      005854
                                                                           005781
BENZENE                              000071-43-2
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUNO HEALTH RISK TECHNICAL  SUPPORT CENTER: (513)  569-7300
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
BENZENETHIOL  / (THIOPHENOL)       000108-98-5
     LOAEL 0.1 MG/(KG-DAY)      RAT
             ORAL: GAVAGE      90 DAYS       LIVER
 CENTRILOBULAR EOSINOPHILIC
 CHANGES
                                                                                                       1E-4
                                                                                                       1000
                                 1E-5
                                 10.000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] UNDER REVIEW BY THE  RfD/RfC WORKGROUP WAS MODIFIED TO ESTIMATE THE
                                SUBCHRONIC ORAL [RfD].
          010942
BENZIDINE     '                      000092-87-5
     LOAEL 2.7 MG/KG/DAY        MOUSE
             ORAL: DRINKING    33 MONTHS     BRAIN
             WATER                          LIVER
 CELLULAR CHANGES
 CELLULAR CHANGES
            3E-3
            1000
IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (03/28/91) BY THE  RfD/RfC WORK GROUP.
005830
                                                                           010877
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                     1-11

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
             TARGET
CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(IDQ/CLI m)  (ma/kq/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
BENZO[A]ANTHRACENE                 000056-55-3
            CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP.
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                       010965
BENZOIC  ACID
     NOAEL 312 MG/DAY
             ORAL: DIET
       000065-85-0
HUMAN
                             NONE OBSERVED
                                           4E+0
                                           1
                                                                                             IRIS
            SUBCHRONIC [RfD] COMMENT:  THE HUMAN DAILY  PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE  LEVEL. THE CHRONIC ORAL RfD
                              WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            CHRONIC [RfD] COMMENT:  THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL.


BENZO[B]FLUORANTHENE              000205-99-2
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513)  569-7300.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                           005260
BENZYL ALCOHOL
     LOAEL 286 MG/KG/DAY
             ORAL: GAVAGE
       000100-51-6
RAT
103 WEEKS     FORESTOMACH     EPITHELIAL HYPERPLASIA
                                                                 3E-1
                                                                 1000
                                            005855
     NOAEL 143 MG/KG/DAY         RAT
             ORAL: GAVAGE      13 WEEKS
             WHOLE BODY
 DECREASED WEIGHT
            1E+0
            100
                                                                                                       005856
 IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                  1-12

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)                  May 1995

                                                                                                    Subchronic           Chronic
CHEMICAL     DOSE.          SPECIES                                                           [RfC]      [RfD]       [RfC]       [RfD]    REFERENCE
LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL EFFECT                 (mo/cu m) (tng/kg/dav)   (ma/cu m) (mg/ka/dav)
                                                                                             UF         UF          UF        UF

BERYLLIUM                           007440-41-7
     NOAEL 0.54 MG/KG/DAY       RAT
             ORAL: DRINKING    LIFETIME                      NONE OBSERVED                              5E-3                 IRIS       005262
             WATER                                                                                    100

            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED  AS THE SUBCHRONIC ORAL  [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.


BIPHENYL.  1.1'                      000092-52-4
     NOAEL 50 MG/KG/DAY         RAT
             ORAL: DIET        700 DAYS      KIDNEY           DAMAGE                                    5E-2                 IRIS       005857
                                                                                                      1000

            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED  AS THE SUBCHRONIC ORAL  [RfD].
                                                                                                                 IRIS                  010878
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (09/20/90)  BY THE RfD/RfC  WORK GROUP.


BIS(2-CHLOROISOPROPYL) ETHER     039638-32-9
     NOAEL 35.8 MG/KG/DAY       MOUSE
             ORAL: DIET        2 YEARS       ERYTHROCYTES     DECREASED  HEMOGLOBIN                       4E-2                 IRIS       010257
                                                                                                      1000

            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

BIS(2-ETHYLHEXYL)  PHTHALATE /  (DEHP)     000117-81-7
                                                                                                                           IRIS       010859
            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE SUPERFUNO HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            SUBCHRONIC [RfD]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.                    1-13

-------
                                 HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC  TOXICITY (OTHER THAN CARCIN06ENICITY)
                                                                                                                                      May 1995
CHEMICAL    DOSE
LEVEL       ROUTE
                     SPECIES
                EXPERIMENT LENGTH
      TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(ma/cu m)  (ma/kg/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF         UF
BISPHENOL  A

     NOAEL 750 PPM
             ORAL
                          RAT
                         13 WEEKS
000080-05-7


      WHOLE BODY
 DECREASED WEIGHT
            6E-1
            100
                                                                                                                      IRIS
                     005268

                     005266
BORON TRIFLUORIDE
     NOAEL 6 MG/CU M
             INHALATION:
             INTERMITTENT
                                 007637-07-2
                          RAT
                         13 WEEKS
      KIDNEY
 NECROSIS
 7E-3
 300
7E-4
3000
                                                                                                010395
BORON. ELEMENTAL                   007440-42-8
     NOAEL 8.8 MG/KG/DAY        DOG
             ORAL: DIET       2 YEARS       TESTIS
                                                       LESIONS
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                               HUMAN
LOAEL 4.5 MG/CU M
        INHALATION:
        INTERMITTENT
                                            RESPIRATORY
                                            TRACT
                                            BRONCHUS
                      IRRITATION

                      BRONCHITIS
                                2E-2
                                100
                                                                9E-2
                                                                100
            SUBCHRONIC [RfC]  COMMENT:  THE SUBCHRONIC INHALATION [RfC]  IS SPECIFICALLY FOR ANHYDROUS BORAX.
            CHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC] IS SPECIFICALLY FOR ANHYDROUS BORAX.
                      2E-2
                      100
                                                                IRIS
                                           005272
                     005269
BROHINATED DIBENZO-P-DIOXINS
            GENERAL COMMENT:   DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                005858
BRONINATED DIBENZOFURANS
            GENERAL COMMENT:   DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                005859
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                           1-14

-------
                                  HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May  1995
 CHEMICAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT  LENGTH
              TARGET
CRITICAL EFFECT
 BROMOACETONE                       000598-31-2
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu m)  (ma/ka/dav)   (ITIQ/CU m)  (ma/kq/dav)
   UF         UF           UF        UF
                                                                                                                                      005860
 BROMOCHLOROETHANES
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                      005861
BROHODICHLOROHETHANE
     LOAEL 17.9 MG/KG/DAY
             ORAL: GAVAGE
       000075-27-4
MOUSE
102 WEEKS     KIDNEY
                                                            CYTOMEGALY
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BROMOETHENE  / (VINYL BROMIDE)    000593-60-2
     LOAEL 9.7 PPM             RAT
              INHALATION:       24 MONTHS
              INTERMITTENT
             LIVER
             LIVER
             LIVER
 HYPERTROPHY
 BASOPHILIC FOCI
 EOSINOPHILIC FOCI
 3E-3
 3000
                                                                        2E-2
                                                                        1000
            SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC  INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC]
            GENERAL COMMENT:   ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
BROMOFORM                           000075-25-2
     NOEL  17.9 MG/KG/DAY       RAT
             ORAL: GAVAGE      13 WEEKS      LIVER
                             EFFECTS
                                                                                                      2E-1
                                                                                                      100
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS
                                                                                                                            IRIS
                                                                                             IRIS
                                                                           005715
010929
                                                                           005722
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP.
                                                                                                       010961
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-15

-------
                                 HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER  THAN  CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DQSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (ma/ka/dav)   (mo/cu m)  (ma/kg/dav)
   UF          UF           UF        UF
BROHOHETHANE
       000074-83-9
            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            SUBCHRONIC [RfD]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
                                                                                                                 IRIS
                                                                                                                           IRIS
                                                                                                       010861
                                                                                                       010860
BROMOPHENYL PHENYL  ETHER.  4-     000101-55-3
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       005864
BROMOPHOS
     NOAEL 5 MG/KG/DAY
             ORAL: DIET
       002104-96-3
 RAT
3            BLOOD
GENERATIONS
             LIVER
 DECREASED CHOLINESTERASE
 ACTIVITY
 DECREASED CHOLINESTERASE
 ACTIVITY
            SUBCHRONIC [RfD] COMMENT:  BASED ON A REPRODUCTION STUDY.
            CHRONIC [RfD] COMMENT:   BASED ON A REPRODUCTION STUDY.
 BROMOXYNIL                          001689-84-5
     NOEL  5 MG/KG/DAY          RAT
              ORAL: DIET        2 YEARS
                              NONE OBSERVED
            5E-2
            100
                                            2E-2
                                            300
             SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
5E-3
1000
                                                                                             IRIS
                                                                           005865
                                                                           005866
 MS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                 1-16

-------
                                  HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                      May 1995
 CHEMICAL    fiQSl          SPECIES-
 LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET
                     CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu ro)  (ma/ka/dav)   (ma/cu m)  (mo/kQ/dav)
   UF         UF          UF         UF
 BROMOXYNIL OCTANOATE
      NOEL   7.3 MG/KG/DAY        RAT
              ORAL:  DIET       2 YEARS
001689-99-2
                                                            NONE OBSERVED


             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].


 BUSAN 77                            031512-74-0
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT-.


 BUSAN 90                            002491-38-5
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                2E-2
                                                                300
 BUTANOL. 1-
     NOAEL 125 MG/KG/DAY        RAT
             ORAL: GAVAGE      13 WEEKS
000071-36-3
      CENTRAL NERVOUS  HYPOACTIVITY
      SYSTEM
      CENTRAL NERVOUS  ATAXIA
      SYSTEM
                                                                                                      1E+0
                                                                                                      100
                                 IRIS       005867
                                                                                                005868
                                                                                                                                     005869
                                IRIS       005870
BUTYL BENZYL  PHTHALATE.  N-        000085-68-7
     NOAEL 159 MG/KG/DAY        RAT
             ORAL: DIET       26 WEEKS      LIVER
                      ALTERED WEIGHT
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      2E+0
                                                                                                      100
                                                                                     IRIS
                                           005616
IRK.  EPA-S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                               1-17

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                               May 1995
CHEMICAL     DQSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                              (ma/cu m)  (ma/ka/day)   (ma/cu m)  (ma/ka/dav)
                                 UF          UF           UF         UF
BUTYLATE                             002008-41-5
     NOEL  5 MG/KG/OAY          DOG
             ORAL: CAPSULE      12 MONTHS     LIVER            INCREASED RELATIVE WEIGHT


            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                          5E-2
                                          100
                                                               IRIS      005871
BUTYLCHLORIDE.  T-                  000507-20-0
            GENERAL COMMENT:   DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                          005810
BUTYROLACTONE.  GAMMA-             000096-48-0
            GENERAL COMMENT:   DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                          005872
CACODYLIC ACID                     000075-60-5
     NOEL  9.2 MG/KG/DAY        RAT
             ORAL: DIET        90 DAYS
NONE OBSERVED
3E-2
300
             SUBCHRONIC [RfD] COMMENT-  CALCULATED BY ANALOGY TO ARSENIC BY  CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
             CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
3E-3
3000
                                                                          005873
 CADMIUM                             007440-43-9
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                       IRIS
                       005280
 IRIS.  EPA-S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                     1-18

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)                  May 1995

                                                                                                     Subchronic           Chronic
CHEMICAL    DOSE           SPECIES                                                            [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
LEVEL       ROUTE     EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT                 (iro/cu m)  (ma/ka/dav)   (ma/cu m)  (ma/ka/day)
                                                                                              UF        UF           UF        UF

CALCIUM CYANIDE                    000592-01-8
     NOAEL  19.1 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS       WHOLE BODY       DECREASED WEIGHT                           4E-2                  IRIS       010258
                                            THYROID         EFFECTS                                    500
                                            NERVE           MYELIN DEGENERATION

            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
                              THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD]
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.


CAPROLACTAH                         000105-60-2
                                                                                                                            IRIS       005284
     NOAEL  50 MG/KG/DAY         RAT
             ORAL: DIET        90 DAYS       KIDNEY          EFFECTS                                    5E-1                             005282
                                                                                                       100

                                                                                                                  IRIS                  010966

CAPTAFOL                             002425-06-1
     LOAEL  2 MG/KG/DAY          DOG
             ORAL: CAPSULE     12 MONTHS     KIDNEY          EFFECTS                                    2E-3                  IRIS       005874
                                            BLADDER         EFFECTS                                    1000

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.                     1-19

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN  CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL     DOSE          SPECIES
LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
                      CRITICAL EFFECT
          Subchronic
  [RfC]      [RfD]
(IDQ/CU m)  (mg/kg/dav)
   UF         UF
      Chronic
 [RfC]        [RfD]     REFERENCE
(ma/cu m)  (ma/ka/dav)
   UF        UF
CAPTAN
     NOEL  12.5 MG/KG/DAY
             ORAL: DIET
RAT
000133-06-2

      WHOLE BODY
                             DECREASED WEIGHT
                                                                                                        1.3E-1
                                                                                                        100
                                 IRIS
             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
             CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED  NOT VERIFIABLE (05/27/92) BY THE RfD/RfC WORK GROUP.
             CHRONIC [RfD] COMMENT:  BASED ON A MULTI-GENERATION REPRODUCTION STUDY.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CARBARYL
     NOAEL 9.6 MG/KG/DAY        RAT
             ORAL: DIET        2 YEARS
       000063-25-2

             KIDNEY
             LIVER
                      TOXICITY
                      TOXICITY
            1E-1
            100
                                                                                                                             IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                                                                   IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (08/15/91) BY THE RfD/RfC WORK GROUP.
                                                                                                 005875
                     005876
                                                                                                        010882
CARBOFURAN
     NOEL  0.5 MG/KG/DAY         DOG
             ORAL: DIET        1 YEAR
       001563-66-2

             BLOOD
             TESTIS
             UTERUS
                      CHOLINESTERASE INHIBITION
                      EFFECTS
                      EFFECTS
            5E-3
            100
          IRIS
                                                                                                                                        005877
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS  THE SUBCHRONIC ORAL [RfD].
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-20

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
 CHEMICAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 CARBON DISULFIDE
     NOEL  11 MG/KG/DAY
              INHALATION:
              INTERMITTENT
        000075-15-0
 RABBIT
             FETUS
CRITICAL EFFECT
 TOXICITY
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfO]    REFERENCE
(mq/cu m)  (ma/ka/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
                                                                        1E-1
                                                                        100
                                                                 IRIS
             SUBCHRONIC [RfD] COMMENT:   THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
             CHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS DETERMINED FROM A TERATOLOGY STUDY WITH  EXPOSURES BEFORE AND DURING
                              THE ENTIRE GESTATION PERIOD.
     NOAEL 10 MG/CU M
              INHALATION:
              INTERMITTENT
 RAT
GESTATION    FETUS
 TOXICITY
                                                              1E-2
                                                              1000
                                                      1E-2
                                                      1000
             SUBCHRONIC [RfC] COMMENT:   THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
                                            010259
                                            010430
CARBON  MONOXIDE                    000630-05-0
            CHRONIC [RfC] COMMENT:   REFER TO APPENDIX A:  TECHNICAL  INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
                                                                                                        010493
CARBON  TETRACHLORIOE
       000056-23-5
CHLORAL
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER-  (513) 569-7300
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.   .
             LOAEL 15.7 MG/KG/DAY
             ORAL: DRINKING    90 DAYS
             WATER
       000075-87-6

              MOUSE
             LIVER
 EFFECTS
                                                                        2E-2
                                                                        1000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
                                                                                                                             IRIS
                                                                 IRIS
                                                                                                        010862
                                            005290
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                   1-21

-------
                                 HEAST TABLE 1:   SU8CHRONIC  AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                      May  1995
CHEMICAL     DQSE.          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH      TARGET
                     CRITICAL EFFECT
                                        Subchronic           Chronic
                                [RfC]     [RfD]       [RfC]       [RfD]     REFERENCE
                              (mg/cu m)  (inq/kq/dav)   (mo/cu m)  (mq/ka/day)
                                 UF         UF          UF        UF
CHLOROANE                            000057-74-9
     NOEL 0.055 MG/KG/DAY      RAT
             ORAL:  DIET        130 WEEKS     LIVER
                      HYPERTROPHY
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC  ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORINE  CYANIDE
     NOAEL  25.3 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS
000506-77-4

      WHOLE  BODY
      THYROID
      NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC  ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
CHLORO-1.3-BUTADIENE. 2-   /  (CHLOROPRENE)   000126-99-8
     NOAEL 32 PPM               RAT
              INHALATION        90  DAYS       OLFACTORY        DEGENERATION
                                            EPITHELIUM
                                                      7E-2
                                                      30
                                          6E-5
                                          1000
5E-2
500
                                                                                     IRIS      005296
                                                               IRIS
                                                     7E-3
                                                     300
010261
                                                                                                010515
            SUBCHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLORO-M-CRESOL. P-                000059-50-7
     NOAEL 200 MG/KG/DAY        RAT
             ORAL: GAVAGE      28 DAYS       WHOLE BODY
                      DECREASED WEIGHT GAIN
                                          2E+0
                                          100
                                                                                                005366
CHLOROACETALDEHYDE                 000107-20-0
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                005342
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                          1-22

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                              (im/cu m) (mg/ka/dav)   (ma/cu m)  (ma/ka/day)
                                 UF         UF          UF        UF
CHLOROACETIC ACID
     LOAEL  30 MG/KG
             ORAL:  GAVAGE
       000079-11-8
 RAT
13 WEEKS
HEART
MYOCARDITIS
2E-2
1000
2E-3
10000
                                                                                          005346
CHLOROANILINE.  2-                 000095-51-2
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      005347
CHLOROANILINE.  3-                 000108-42-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      005348
CHLOROANILINE.  4-
     LOAEL  12.5 MG/KG/DAY
             ORAL: DIET
       000106-47-8
 RAT
78 WEEKS
SPLEEN
PROLIFERATE  LESIONS
            SUBCHRONIC [RfD] COMMENT:  THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHLOROBENZENE
       000108-90-7
4E-3
3000
IRIS
                                                                                                                           IRIS
                                                                                          005349
                                                                                                       010863
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513)  569-7300.
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513)  569-7300.
            CHRONIC [RfC]  COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-23

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
                                               CRITICAL EFFECT
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]
(mq/cu m)  (mQ/kQ/day)   (mq/cu m) (mq/kq/day?
   UF         UF           UF        UF
                                                                                                               May 1995


                                                                                                          REFERENCE
CHLOROBENZILATE                    000510-15-6
     NOEL  5 MG/KG/DAY           RABBIT
             ORAL: GAVAGE      13 DAYS
                                                                                                       2E-2
                                                                                                       300
                                                                                              IRIS
                                GASTRO-          DECREASED STOOL QUANTITY
                                INTESTINAL  SYSTEM
                                WHOLE BODY       DECREASED FOOD CONSUMPTION
                                WHOLE BODY       DECREASED WEIGHT GAIN
                                NERVOUS  SYSTEM   HYPERIRRITABILITY

SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]. BASED ON A TERATOLOGY STUDY WITH
                   EXPOSURES DURING DAYS 7-19 OF GESTATION.
CHRONIC [RfD]  COMMENT:  BASED ON A TERATOLOGY STUDY WITH EXPOSURES DURING DAYS 7-19 OF GESTATION.

CHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP.
                                            010260
                                                                                                                                       010931
CHLOROBENZOIC  ACID.  P-
     NOAEL 26 MG/DAY
             ORAL: DIET
        000074-11-3
 RAT
5 MONTHS
                                                NONE OBSERVED
                                                                                                       2E+0
                                                                                                       100
                                                                                              2E-1
                                                                                              1000
                                                                                                                           005360
CHLOROBENZOTRIFLUORIDE.  4-       000098-56-6
     NOAEL 15 MG/KG/DAY         RAT
             ORAL: GAVAGE                   KIDNEY
                              TUBULAR DEGENERATION
                                                                                                       2E-1
                                                                                                       100
                                                                                                                2E-2
                                                                                                                1000
            SUBCHRONIC [RfD] COMMENT:  BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING.
                              DURING GESTATION, AND FOR 90  DAYS POST-WEANING.
            CHRONIC [RfD] COMMENT:  BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING.  DURING
                              GESTATION. AND FOR 90 DAYS POST-WEANING.
                                                                                                        005364
MS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                   1-24

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER  THAN  CARCINOGENICITY)
LEVEL
             BQSE          SPECIES
             ROUTE    EXPERIMENT LENGTH
                                            TARGET
CRITICAL EFFECT
 CHLOROBUTANE. 1-
      NQAEL 43 MG/KG/DAY
              ORAL: GAVAGE
                                     000109-69-3
                               RAT
                              103 WEEKS    WHOLE BODY       INCREASED MORTALITY
                                           CENTRAL NERVOUS   EFFECTS
                                           SYSTEM
                                           BLOOD            HEMATOLOGIC EFFECTS
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]
(ma/cu m)  (ma/ko/dav)   (IDQ/CU m)  (im/kg/dav)
   UF        UF           UF        UF
                                                                                                                                            May 1995


                                                                                                                                       REFERENCE
                                                                                                                            4E-1
                                                                                                                            100
                                                                           005808
     NOAEL 86 MG/KG/DAY         RAT
              ORAL: GAVAGE      13 WEEKS
                                           WHOLE BODY
                                           CENTRAL NERVOUS
                                           SYSTEM
                                           SPLEEN
 DECREASED WEIGHT GAIN
 EFFECTS

 HEMATOPOIESIS
                                                                                                       9E-1
                                                                                                       100
                                           005806
CHLOROBUTANE.  2-                   000078-86-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                      005809
CHLOROCYCLOPENTADIENE             041851-50-7
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                     005297
CHLOROFORM
     LOAEL 12.9 MG/KG/DAY
             ORAL: CAPSULE
                                     000067-66-3
                              DOG
                              7.5 YEARS     LIVER
                                                            LESIONS
                                                                                                       1E-2
                                                                                                       1000
                                                                                                                           IRIS       005372
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS  THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                1-25

-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) May 1995

Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfO] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mq/cu m) (mq/kq/dav) (ma/cu m) (ina/ka/dav)
UF UF UF UF

CHLOROMETHANE / (METHYL CHLORIDE) 000074-87-3
010005
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUNO HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

CHLORONITROBENZENE. H- 000121-73-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005879

CHLORQPHENOL. 2- 000095-57-8
NOAEL 50 PPM RAT
ORAL- DRINKING REPRODUCTION REPRODUCTIVE EFFECTS 5E-2 IRIS 010436
WATER 100

SUBCHRONIC [RfD] COMMENT- BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING. GESTATION AND WEANING.
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING. GESTATION AND WEANING.

CHLOROPHENOL. 3- 000108-43-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005309

CHLOROPHENOL. 4- 000106-48-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005310

CHLOROPROPANE. 2- 000075-29-6
NOAEL 91.4 MG/KG/DAY RAT
INHALATION: 4 WEEKS LIVER EFFECTS 1E+0 1E-1 010444
INTERMITTENT 100 1000

CHLOROTOLUENE. H- 000108-41-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005880
IRIS. EP/CS INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 1-26

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfO]     REFERENCE
                              (mg/cu m) (mg/ka/dav)   (rna/cu m)  (ma/ka/dav)
                                 UF         UF          UF        UF
CHLOROTOLUENE. 0-
     NOAEL 20 MG/KG/DAY
             ORAL:  GAVAGE
       000095-49-8
 RAT
103 DAYS
WHOLE BODY
DECREASED WEIGHT GAIN
2E-1
100
                                                                               IRIS
                                                                          010167
CHLOROTOLUENE.  P-                 000106-43-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       010200
CHLORPYRIFOS                       002921-88-2
     NOEL  0.03 MG/KG/DAY       HUMAN
             ORAL:  CAPSULE     20 DAYS OR    BLOOD
                              9 DAYS
                             DECREASED CHOLINESTERASE
                             ACTIVITY
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                          3E-3
                                                          10
                                                               IRIS       005881
CHLORPYRIFOS METHYL
     NOAEL  1 MG/KG/DAY
             ORAL:  DIET
       005598-13-0
 RAT
3            REPRODUCTION
GENERATIONS
                DECREASED FERTILITY
                                          1E-2
                                          100
                     1E-2       005882
                     100
                              RAT
                              2 YEARS
             LIVER
                EFFECTS
CHLOROTHALONIL                       001897-45-6
     NOEL  1.5 MG/KG/DAY        DOG
             ORAL:  DIET       2 YEARS      KIDNEY
                             EFFECTS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                           1.5E-2
                                                           100
                                                                IRIS       005883
IRIS,  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-27

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN  CARCINOGENICITY)
                                                                                                              May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT
                                                                      Subchronic          Chronic
                                                              [RfC]      [RfO]       [RfC]       [RfD]     REFERENCE
                                                            (mg/cu m) (mq/kq/dav)    (ma/cii m) (im/kg/day)
                                                               UF         UF          UF         UF
CHLORTHIOPHOS                      060238-56-4
     NOAEL 0.08 MG/KG/DAY       RAT
             ORAL: DIET        2  YEARS                       NONE OBSERVED


            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                        8E-4
                                                                        100
                                                                8E-4       005884
                                                                100
CHROMIUM(III)
     NOEL  5 %  (CR203)
             ORAL: DIET
       016065-83-1
 RAT
840 DAYS
NONE OBSERVED
lE-t-0
1000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            CHRONIC [RfC] COMMENT:   INHALATION ISSUES ARE  UNDER REVIEW BY THE RFD/RFC WORK GROUP.
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL  SUPPORT CENTER. (513) 569-7300.
CHROMIUM(VI)
     NOAEL 2.4 MG/KG/DAY
             ORAL: DRINKING
             WATER
       018540-29-9
 RAT
1 YEAR
NONE OBSERVED
2E-2
100
            CHRONIC [RfC] COMMENT:   INHALATION ISSUES ARE UNDER REVIEW BY THE RFD/RFC WORK GROUP.
            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL  SUPPORT CENTER: (513) 569-7300
IRIS
                                                                                                                                       005731
IRIS
                                                                                                        005522
CHRYSENE                             000218-01-9
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                        005885
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-28

-------
 CHEMICAL
 LEVEL
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                                May 1995
DOSE
ROUTE
     SPECIES
EXPERIMENT LENGTH
                                             TARGET
                                               CRITICAL EFFECT
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mq/cu m)  (ma/kq/dav)   (iro/cu m)  (im/kQ/dav)
   UF         UF           UF        UF
COPPER
     LQAEL 5.3 MG
              ORAL
                         007440-50-8
                   HUMAN
                  SINGLE  DOSE   GASTRO-
                                                             IRRITATION
                                                                                          1.3 MG/L
                                                                                                      1.3 MG/L   005374
                                            INTESTINAL SYSTEM
             SUBCHRONIC [RfD] COMMENT:  CURRENT DRINKING WATER STANDARD OF 1.3 MG/L.  DWCD  (1987) CONCLUDED TOXICITY  DATA WERE
                              INADEQUATE FOR CALCULATION OF AN RfD FOR COPPER.
             CHRONIC [RfD] COMMENT:   CURRENT DRINKING WATER STANDARD OF 1.3 MG/L.  DWCD  (1987) CONCLUDED TOXICITY DATA WERE
                              INADEQUATE FOR CALCULATION    OF AN RfO FOR COPPER.
COPPER  CYANIDE
     NOAEL 5 MG/KG/DAY
             ORAL: GAVAGE
                         000544-92-3
RAT
90 DAYS
LIVER
KIDNEY
WHOLE BODY
ORGANS
HISTOPATHOLOGY
HISTOPATHOLOGY
DECREASED WEIGHT
DECREASED WEIGHT
                                                                                                       5E-2
                                                                                                       100
                                                                                                               IRIS
                                                                                                                 010262
CRESOL.  M-   /  (3-METHYLPHENOL)
     NOAEL 50 MG/KG/DAY         RAT
             ORAL: GAVAGE      90  DAYS
                          000108-39-4

                               WHOLE BODY       DECREASED WEIGHT GAIN
                               NERVOUS SYSTEM   NEUROTOXICITY
                                                                                                       5E-1
                                                                                                       100
                                                                                                      IRIS
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                                  IRIS
            CHRONIC RfC COMMENT:   THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE RfD/RfC WORK GROUP.
                                            005380
                                                                                                                          010888
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                    1-29

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                         Subchronic           Chronic
                                 [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                               (mq/cu m)  (mQ/ka/dav)   (mg/cu  m)  (mq/kq/dav)
                                  UF         UF           UF        UF
CRESOL.  0-  /  (2-METHYLPHENOL)   000095-48-7
     NOAEL 50 MG/KG/DAY         RAT
             ORAL: GAVAGE      90 DAYS
              WHOLE BODY       DECREASED WEIGHT GAIN
              NERVOUS SYSTEM   NEUROTOXICITY
            GENERAL COMMENT:   ALSO SEE  HEAST TABLE 3:  CARCINOGENICITY.
                                                           5E-1
                                                           100
                                                                                                                             IRIS
                                                                                                                  IRIS
            CHRONIC RfC COMMENT:   THE  CHRONIC INHALATION RfC  IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE RfD/RfC WORK GROUP.
                                                                           005384
                                                                                                        010889
CRESOL.  P-  /  (4-METHYLPHENOL)   000106-44-5
     NOAEL 5 MG/(KG-DAY)        RABBIT
             ORAL: GAVAGE      GESTATION     CENTRAL NERVOUS  HYPOACTIVITY
                               DAYS  6-18     SYSTEM
                                            RESPIRATORY      DISTRESS
                                            SYSTEM
                                            WHOLE BODY      MATERNAL DEATH

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                        5E-3
                                                                        1000
                                                                                5E-3
                                                                                1000
                                                                           010516
                                                                                                                  IRIS
            CHRONIC RfC COMMENT:   THE  CHRONIC INHALATION  RfC  IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE RfD/RfC WORK GROUP.
                                                                                                        010890
CUMENE
     NOAEL 154 MG/KG/DAY
             ORAL: GAVAGE
     NOAEL 105.1 PPM
             INHALATION:
             INTERMITTENT
        000098-82-8
 RAT
194 DAYS
 RAT
4 WEEKS
KIDNEY
INCREASED WEIGHT
CENTRAL NERVOUS  INVOLVEMENT
SYSTEM
NOSE            IRRITATION
4E-1
300
                                                                                                                            IRIS
                                9E-2
                                1000
                                                                                   9E-3
                                                                                   10000
                                                                                                        005392
                                005908
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                   1-30

-------
                                  HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                              May 1995
LEVEL
             DOSE          SPECIES
             ROUTE    EXPERIMENT LENGTH
                                             TARGET
 CYANAZINE
     NOEL  0.625 MG/KG/DAY      DOG
              ORAL:  DIET       1 YEAR
                                      021725-46-2

                                            WHOLE BODY
                                            BLOOD
                                            BLOOD
CRITICAL EFFECT
 DECREASED WEIGHT
 INCREASED PLATELET COUNT
 ALTERED CLINICAL CHEMISTRY
 PARAMETERS
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mo/cu m)  (ma/kq/dav)   (ma/cu m) (mg/kg/dav)
   UF         UF           UF         UF
                                                                                                        2E-3
                                                                                                        300
                                 2E-3
                                 300
010411
             SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
             CHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS WITHDRAWN FROM IRIS  (07/01/92).  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE
             GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CYANIDE
     NOAEL 10.8 MG/KG/DAY
             ORAL: DIET
                                      000057-12-5
                               RAT
                              104 WEEKS     WHOLE  BODY
                                            THYROID
                                            NERVE
                                                             DECREASED WEIGHT
                                                             EFFECTS
                                                             MYELIN DEGENERATION
                                            2E-2
                                            500
                                 IRIS
005396
            SUBCHRONIC [RfD] COMMENT:   THE  CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  THE CASRN FOR CN- IS 000057-12-5: THE CASRN FOR HCN  IS 000074-90-8
CYANOGEN
     NOAEL 21.6 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS
                                      000460-19-5

                                            WHOLE BODY
                                            THYROID
                                            NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
                                                                                                        4E-2
                                                                                                        500
                                 IRIS
010263
            SUBCHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR  WEIGHT  THE CHRONIC ORAL RfD
                               WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                  1-31

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mo/cu m)  (ma/lca/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
CYANOGEN  BROMIDE
     NOAEL  44 MG/KG/OAY         RAT
             ORAL:  DIET       2 YEARS
       000506-68-3

             WHOLE BODY
             THYROID
             NERVE
 DECREASED WEIGHT
 EFFECTS
 MYELIN DEGENERATION
            9E-2
            500
                                                                IRIS
            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY  TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN  MOLECULAR WEIGHT.
                             THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
010264
CYCLOATE                             001134-23-2
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       005886
CYCLOHEXANOL                        000108-93-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       005887
CYCLOHEXYLANINE

     NOAEL 30 MG/KG/DAY
             ORAL: DIET
       000108-91-8

 RAT
90 DAYS      WHOLE BODY
             TESTIS
 DECREASED WEIGHT GAIN
 DECREASED WEIGHT
            3E-1
            100
                                                                 IRIS
005400

005398
CYCLOPENTADIENE
        000542-92-7
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                      010494
 MS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                  1-32

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                             May 1995
 LEVEL
                           SPECIES
            ROUTE     EXPERIMENT LENGTH
                                             TARGET
                             CRITICAL  EFFECT
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mq/cu m)  (ma/ka/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
DACTHAL
     NQAEL 1  MG/KG/DAY
             ORAL:  DIET
                                      001861-32-1
RAT
2 YEARS






LUNG
LIVER
KIDNEY
THYROID
THYROID
HORMONES

EFFECTS
EFFECTS
EFFECTS
EFFECTS
EFFECTS

                                                                                                       1E-2
                                                                                                       100
                                                                                                                            IRIS
OALAPON
     NOEL  8.45 MG/KG/DAY
             ORAL: DIET
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                                      000075-99-0

                                            KIDNEY           INCREASED RELATIVE WEIGHT
 RAT
2 YEARS
                                                                                                       3E-2
                                                                                                       300
                                                                                              IRIS
            SU8CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO DALAPON SODIUM BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
                              THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DDT
                                      000050-29-3
     NOEL  0.05 MG/KG/DAY       RAT
             ORAL: DIET        27 WEEKS
                                           LIVER
                              LESIONS
                                                                                                       5E-4
                                                                                                       100
                                                                                                                            IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
DECABROMODIPHENYL ETHER           001163-19-5
     NOEL  1  MG/KG/DAY          RAT
             ORAL: DIET        2 YEARS       LIVER
                                                            INCREASED WEIGHT
                                                                                                       1E-2
                                                                                                       100
                                                                                                                            IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                        005888
                                            005889
                                                                                                        005408
                                                                                                        005891
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                 1-33

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                                              May 1995
CHEMICAL
LEVEL
ROUTE
                          SPECIES
                     EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(ma/cu m)  (ma/kq/dav)   (IHQ/CU m)  (ma/ka/dav)
   UF         UF          UF         UF
DI-N-OCTYL  PHTHALATE
     LOAEL  175 MG/KG/DAY
             ORAL:  DIET
                         000117-84-0
                  RAT
                  7-12  MONTHS   KIDNEY
                               LIVER
                               LIVER
                               LIVER
                                                           INCREASED WEIGHT
                                                           INCREASED WEIGHT
                                                           INCREASED SGOT ACTIVITY
                                                           INCREASED SGPT ACTIVITY
                                                         2E-2
                                                         1000
                                                               2E-2
                                                               1000
                                           010275
DIAZINON
     NOAEL 0.09 MG/KG/DAY
            •ORAL:  DIET
                         000333-41-5
                   RAT
                  35-42 DAYS    BLOOD
                                                           DECREASED  CHOLINESTERASE
                                                           ACTIVITY
                                                         9E-4
                                                         100
                                                               9E-4
                                                               100
                                           005892
DIBENZOFURAN                       000132-64-9
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                        005409
DIBROMOBENZENE.  1.4-
     NOAEL  10 MG/KG/DAY
             ORAL:  GAVAGE
                         000106-37-6
                   RAT
                  45 OR 90
                  DAYS
                                           LIVER
                                           LIVER
                INCREASED RELATIVE WEIGHT
               ALTERED ENZYME ACTIVITIES
                                           1E-1
                                           100
                                 IRIS       005893
DIBROHOCHLOROHETHANE
     NOEL  21.4 MG/KG/DAY
             ORAL: GAVAGE
                         000124-48-1
                   RAT
                  13 WEEKS
                                           LIVER
               LESIONS
                                           2E-1
                                           100
                                 IRIS       005894
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3.  CARCINOGENICITY.
MS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                  1-34

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                            May 1995
 CHEMICAL     EQSE          SPECIFY
 LEVEL        ROUTE     EXPERIMENT LENGTH       TARGET
  DIBROMOETHANE. 1.2-               000106-93-4
       LOAEL 88 PPB              HUMAN
               INHALATION:                    SPERM
               INTERMITTENT
                                                           CRITICAL EFFECT
                                                            EFFECTS
                                                                                                     Subchromc          Chronic
                                                                                             [RfC]      [RfDJ       [RfC]       [RfD]     REFERENCE
                                                                                                     (inq/kQ/dav)   (mq/cu m) Imq/ka/dav)
                                                                                                        UF          UF         UF
                                                                                             UF
                                                                                           2E-3
                                                                                           100
                                                                                                                 2E-4
                                                                                                                 1000
                                                                                 £STIMTE TH£
 DIBUTYL  PHTHALATE
      NOAEL 125 MG/KG/DAY
              ORAL:  DIET
                               RAT
                              52 WEEKS
                                      000084-74-2
                                           WHOLE BODY      INCREASED MORTALITY
                                                                                                      1E+0
                                                                                                      100
            CHRONIC RfC COMMENT:  THE  CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE  (07/26/90) BY THE RfD/RfC
DICAHBA
     NOAEL 3 MG/KG/DAY
             ORAL:. GAVAGE
                                      001918-00-9
                               RABBIT
                              GESTATION    FETUS
                              DAYS 6-18    FETUS

                                           FETUS
                                           DAM
                                                           DECREASED WEIGHT
                                                           INCREASED POST-IMPLANTATION
                                                           LOSSES
                                                           INCREASED MORTALITY
                                                           DECREASED WEIGHT GAIN
3E-2
100
            SUBCHRONIC [RfO] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC  ORAL [RfD].


DICHLOROBENZENE.  1.2-             000095-50-1

                   COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC
                                                                                                                          IRIS
IRIS
                                010854
                                005622


                                010892
          010945
                                                                                                                                   o,o»«
   . a. -

                                                                                                                                             1-35

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
 CHEMICAL     DOSE           SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
(mg/cu m)  (ma/ka/day)   (ma/cu m)  (ma/kQ/dav)
   UF         UF           UF         UF
 DICHLOROBENZENE.  1.3-             000541-73-1

            CHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (06/23/92)  BY  THE RfD/RfC WORK GROUP.
                                                                                                       005414
 DICHLOROBENZENE.  1.4-
     NOAEL 75 MG/CU M
              INHALATION:
              INTERMITTENT
       000106-46-7
 RAT
MULTI-GENERA  LIVER
TION
 INCREASED WEIGHT  IN MALE         2.5E+0
 PARENTS                         30
                       IRIS
             SUBCHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION RfC WAS MODIFIED TO ESTIMATE THE SUBCHRONIC INHALATION [RfC].
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                           010840
 DICHLOROBUTENES
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                        005415
 DICHLOROOIFLUOROMETHANE

     NOAEL 90 MG/KG/DAY
              ORAL:  DIET
        000075-71-8
 DOG
90 DAYS
 NONE OBSERVED
            9E-1
            100
                                                                                             IRIS
                                                                           005498

                                                                           005496
             SUBCHRONIC  [RfC] COMMENT-  ALSO SEE HEAST TABLE  2: ALTERNATE METHODS --  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
             CHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                 1-36

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)                May 1995

 CHEMICAL     DOSE          SPFCTFS                                                               Subchronic         Chronic
 L«L       ROUTE    »«&„       T«ET        CRITICAL EFFKT               ,^.,  ,ja..,    "P.,  JMJ..,  "«E
                                                                                        UF        UF          UF        UF
 DICHLOROETHANE,  1.1-             000075-34-3
      NOEL  115 MG/KG/DAY       RAT

              i™*!      13"E£KS                     ™EoesERvED                            j»                 £j      ««
                      EESi              s                           THOOS"  S"BCHROI"C" CHM"C TOXICITV  (OTHER
                         r£S!:  A!^™SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER
                         LUMMtNT.  BASED ON ROUTE TO ROUTE EXTRAPOLATION
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.


 DICHLOROETHANE. 1.2-             000107-06-2

            S5SSS rolm r^ENT:  C°NTACT ™E SUPERFUND HEAL™ RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
            XoTrL£f?] COmENT:  C°NTACT ™E SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300'
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.


 DICHLOROETHYLENE.  1.1-           000075-35-4
     LOAEL 9 MG/KG/DAY          RAT
             ORALR DRINKING    2 YEARS       LIVER           LESIONS                                 9E.3                IRIS       005419
             MAItR                                                                               1000

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED  AS THE SUBCHRONIC ORAL [RfD]
            CHRONIC [RfD]  COMMENT:  UNDER REVIEW.  CURRENT NUMBER SUBJECT TO CHANGE
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                       1-37

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                               May 1995
CHEMICAL    pjfit          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic
  [RfC]      [RfD]
(M/CU m)  (ma/kQ/dav)
   UF        UF
      Chronic
 [RfC]        [RfD]     REFERENCE
(mQ/cu m)  (ina/ko/dav)
   UF        UF
DICHLOROETHYLENE. 1.2-  (MIXED ISOMERS)    000540-59-0
     LOAEL 50 PPM               RAT
             ORAL:  DRINKING    2 YEARS      LIVER           LESIONS
             WATER
                                                         9E-3
                                                         1000
                                                                9E-3
                                                                1000
                                                                                        .010509
            SUBCHRONIC [RfD] COMMENT:  VALUES DERIVED FOR 1.1-DICHLOROETHYLENE  WERE ADOPTED FOR 1.2-  DICHLOROETHYLENE MIXED  ISOMERS

            CHRONIC [RfD]  COMMENT:  VALUES DERJVED FOR 1.1-DICHLOROETHYLENE (000075-35-4) WERE ADOPTED  FOR 1.2-DICHLOROETHYLENE MIXED
                              ISOMERS BASED ON ANALOGY.
DICHLOROETHYLENE.  1.2-C-          000156-59-2
     NOAEL 32 MG/KG/DAY         RAT
             ORAL: GAVAGE      90 DAYS       BLOOD
                                            BLOOD
                DECREASED HEMATOCRIT
                DECREASED HEMOGLOBIN
                                           1E-1
                                           300
                                 1E-2
                                 3000
                                                                                         005420
            C41RONIC [RfD] COMMENT:  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
 DICHLOROETHYLENE.  1.2-T-          000156-60-5
     NOAEL 17 MG/KG/DAY         MOUSE
              ORAL: DRINKING    90 DAYS       BLOOD
              WATER
                INCREASED ALKALINE PHOSPHATASE
                                           2E-1
                                           100
                                                                               IRIS
                                                                           005895
 DICHLOROPHENOL. 2.3-              000576-24-9
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                         005315
 IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                1-38

-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mg/kq/dav) (fia/cu m) (ma/ka/dav)
UF UF UF UF
DICHLORQPHENOL. 2.4-
NOEL 3 PPM RAT
ORAL: DRINKING 2
WATER GENERATIONS
000120-83-2

IMMUNE SYSTEM
ALTERED IMMUNE FUNCTION
3E-3
100'
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES BEFORE AND DURING GESTATION.
PARTURITION. AND WEANING OF PUPS.
IRIS
005314
DICHLOROPHENOL. 2.5- 000583-78-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005316
DICHLOROPHENOL. 2.6- 000087-65-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005317
DICHLOROPHENOL. 3.4- 000095-77-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005318
DICHLOROPHENOL. 3.5- 000591-35-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005319
DICHLOROPHENOXY ACETIC ACID. 2.4- 000094-75-7
NOAEL 1 MG/KG/DAY RAT
ORAL: DIET 91 DAYS BLOOD TOXICITY
LIVER TOXICITY
KIDNEY TOXICITY

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
1E-2
100
IRIS
010265
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-39

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                           May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH      TARGET
                            CRITICAL EFFECT
DICHLOROPHENOXY)  BUTYRIC ACID.  4-(2.4-  / (2.4-DB)     000094-82-6
     NOAEL 8 MG/KG/DAY         DOG
             ORAL: DIET        90 DAYS       CARDIOVASCULAR   HEMORRHAGE
                                           SYSTEM
                                           WHOLE BODY       INCREASED MORTALITY
                                                                                      Subchronic          Chronic
                                                                              [RfC]     [RfD]       [RfC]        [RfD]     REFERENCE
                                                                             (ma/cu m) (ma/ka/dav)   (ITO/CU m)  (ma/kQ/dav)
                                                                               UF         UF          UF         UF
                                                                      8E-2
                                                                      100
                                                                                                             IRIS       005890
DICHLOROPROPANE,  1.1-             000078-99-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
DICHLOROPROPANE.  1.2-
     NQAEL 69.3 MG/CU
             INHALATION:
             INTERMITTENT
       000078-87-5
 RAT
13  WEEKS
                               NASAL MUCOSA     HYPERPLASIA


GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1.3E-2
100
IRIS
                                                                                                     005897
005898
DICHLOROPROPANE.  1.3-             000142-28-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                     005899
DICHLOROPROPANE.  2.2-             000594-20-7
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                     005900
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                               1-40

-------
                                   HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY)
                                                                                                              May 1995
 CHEMICAL     J2QSE           SPECIES
 LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
 DICHLOROPROPENE.  1.3-  /  (TELONE  II)
      NOEL  3 MG/KG/DAY          RAT
              ORAL:  DIET        90 DAYS       ORGANS
      CRITICAL EFFECT


000542-75-6

       INCREASED WEIGHT
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
     NOAEL 5 PPM                MOUSE
              INHALATION:       2 YEARS
              INTERMITTENT
             NASAL MUCOSA     HYPERTROPHY
             NASAL MUCOSA     HYPERPLASIA
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]    REFERENCE
(mq/cu m)  (mg/kq/dav)   (mg/cu m)  (mQ/ka/dav)
   UF          UF           UF        UF
                                                                                                        3E-3
                                                                                                        1000
                                       2E-2
                                       30
             SUBCHRONIC [RfC] COMMENT:   THE  CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION  [RfC].
                      IRIS
                                                                                             IRIS
                                                                                  005901
010351
DICHLORPROP                         000120-36-5
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                       005896
DICYCLOPENTADIENE
     NOEL  32 MG/KG/DAY
             ORAL: DIET
       000077-73-6
RAT
                               GENERATIONS
                                                             NONE  OBSERVED
                                                                        3E-1
                                                                        100
                                                                       3E-2
                                                                       1000
                                                                                                                                       005425
            SUBCHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            SUBCHRONIC [RfD] COMMENT:  BASED ON A 3-GENERATION  REPRODUCTION STUDY.
            CHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfD] COMMENT:   BASED ON A 3-GENERATION REPRODUCTION STUDY.
DIELDRIN                             000060-57-1
     NOAEL  0.005 MG/KG/DAY      RAT
             ORAL: DIET        2  YEARS       LIVER
                             LESIONS
                                                                                                       5E-5
                                                                                                       100
                                                                                             IRIS
                                                                                 005429
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD  WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-41

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                           May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
             TARGET
CRITICAL EFFECT
         Subchronic          Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mg/cu m) (ma/kg/dav)  (mo/cu m) (mg/kg/davJ
   UF         UF          UF        UF
DIETHYL PHTHALATE
     NOAEL 750 MG/KG/DAY
             ORAL: DIET
       000084-66-2
RAT
16 WEEKS      WHOLE BODY
             ORGANS
 DECREASED GROWTH
 DECREASED WEIGHT
           8E+0
           100
IRIS
                                                                         005620
DIETHYL-P-NITROPHENYL  PHOSPHATE           000311-45-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                    005922
DIETHYLANILINE.  N.N-              000091-66-7
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                     005903
DIETHYLENE GLYCOL MONOBUTYL  ETHER     000112-34-5
     NOAEL  18 PPM               RAT
                                                           NONE OBSERVED
                                                            2E-1
                                                            100
                                                     2E-2
                                                     1000
                                                                                                                                   005482
            CHRONIC [RfC] COMMENT:   UNDER REVIEW.
DIETHYLENE GLYCOL MONOETHYL  ETHER    000111-90-0
     NOEL  200 MG/KG/DAY        RAT
             ORAL:  DRINKING                 KIDNEY           HISTOPATHOLOGY
             WATER

            CHRONIC [RfD] COMMENT:  BASED ON A 3-GENERATION REPRODUCTION STUDY.
     NOEL  500 MG/KG/DAY        RAT
             ORAL:  DIET       90 DAYS
             KIDNEY
             TESTIS
 IMPAIRED FUNCTION
 INCREASED WEIGHT
            5E+0
            100
                                                                                           2E+0
                                                                                           100
                                                                          005478
                                                                                                     005476
MS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                1-42

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu m)  (ma/kQ/dav)   (mg/cu m)  (ma/ka/dav)
   UF         UF           UF         UF
DIETHYLFORMAMIDE                   000617-84-5
     NOEL  0.546 MG/DAY. 5 DAYS/WEEK          RAT
             ORAL: GAVAGE      73 WEEKS
                             NONE OBSERVED
                                                                                                     1.1E-2
                                                                                                     100
                                                                               LIE-2     010437
                                                                               100
DIETHYLHYDRAZINE. 1.2-            001615-80-1
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.  ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
                                                                                                       005921
DIMETHOATE                          000060-51-5
     NOEL  0.05 MG/KG/DAY       RAT
             ORAL: DIET       2 YEARS      BRAIN
                             DECREASED CHOLINESTERASE
                             ACTIVITY
            SUBCHRONIC [RfD] COMMENT:   THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                          2E-4
                                                          300
                                 IRIS       005923
DIMETHYLANILINE.  N.N-
     LOAEL 22.32 MG/KG/DAY
             ORAL:  GAVAGE
       000121-69-7
MOUSE
13 WEEKS
SPLEEN
                                                            EFFECTS
            2E-2
            1000
                                                                                            IRIS       005924
DIMETHYLFORMAMIDE. N.N-          000068-12-2
     NOAEL 96 MG/KG/DAY         RAT
             ORAL:  DIET        119 DAYS      LIVER
     LOAEL  22 MG/CU M
             INHALATION:
             INTERMITTENT
HUMAN
                             EFFECTS
             LIVER           EFFECTS
             GASTRO          EFFECTS
             INTESTINAL SYSTEM
                                               3E-2
                                               300
                                                          1E+0
                                                          100
            SUBCHRONIC  [RfC] COMMENT:   THE CHRONIC INHALATION RFC WAS ADOPTED AS  THE SUBCHRONIC INHALATION [RFC].
                      IRIS
                                                                                                                           1E-1
                                                                                                                           1000
                                           005925
010352
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-43

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                [RfC]
                              (mg/cu m)
                                 UF
Subchronic
   [RfO]
dnq/kq/dav)
    UF
      Chronic
 [RfC]        [RfD]
(na/cu m)  (ma/kg/dav)
   UF         UF
                                                                                                                                      REFERENCE
DIMETHYLPHENOL.  2.3-              000526-75-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005926
DIMETHYLPHENOL.  2.4-              000105-67-9
     NOAEL  50 MG/KG/DAY         MOUSE
             ORAL:  GAVAGE      90 DAYS
             NERVOUS SYSTEM   EFFECTS
             BLOOD           ALTERATIONS
                                                          2E-1
                                                          300
                                                                                            IRIS
                                                                                         010266
DIMETHYLPHENOL.  2.5-              000095-87-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                      005928
DIMETHYLPHENOL.  2.6-
     NOEL  0.6 MG/KG/DAY
             ORAL
       000576-26-1
 RAT
8 MONTHS
WHOLE BODY
ORGANS.  MAJOR
INCREASED WEIGHT
LESIONS
  6E-3
  100
                                                                               IRIS
                                                                         005431
DIMETHYLPHENOL.  3.4-
     NOEL  1.4 MG/KG/DAY
             ORAL
       000095-65-8
 RAT
8 MONTHS
WHOLE BODY
ORGANS.  MAJOR
CARDIOVASCULAR
SYSTEM
DECREASED WEIGHT
LESIONS
ALTERED BLOOD PRESSURE
  1E-2
  100
                                                                               IRIS
                                                                         005437
DIMETHYLPHTHALATE                  000131-11-3
            CHRONIC RfD COMMENT-  THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (02/16/94) BY THE RfD/RfC WORK GROUP.
                                                                                                               IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC  IS CONSIDERED NOT VERIFIABLE (07/26/90) BY THE RfD/RfC WORK GROUP.
                                                                                                      010267
                                                                                                      010894
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                1-44

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
 CHEMICAL     QQSI          SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL EFFECT
                                                                     Subchronic          Chronic
                                                             [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                                           (mg/cu m) (mq/kq/dav)   (mq/cu m)  (mq/kq/dav)
                                                              UF         UF          UF        UF
 DIMETHYLTEREPHTHAUTE             000120-61-6
     LOAEL 125 MG/KG/DAY        RAT
              ORAL: DIET       103 WEEKS    KIDNEY           INFLAMMATION


            SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
                                                                       1E-1
                                                                       1000
                                                                               IRIS       005930
DIMETHYLUREA.  N.N-                 000598-94-7
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                   005931
DINITRO-0-CRESOL. 4.6-           000534-52-1
            CHRONIC [RfC]  COMMENT:  THE  CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE  (02/11/93) BY THE RfD/RfC WORK GROUP.        010470

DINITRO-P-CRESOL. 2.6-           000609-93-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT                                                         005934
DINITROBENZENE.  1.2-
     NOAEL  0.4 MG/KG/DAY
             ORAL:  DRINKING
             WATER
       000528-29-0
RAT
16 WEEKS
SPLEEN
                             INCREASED WEIGHT
            SUBCHRONIC  [RfD] COMMENT:   DERIVED BY ANALOGY TO 1.3-DINITROBENZENE
            CHRONIC [RfD] COMMENT:   DERIVED BY ANALOGY TO 1.3-DINITROBENZENE.
                                                                       4E-3
                                                                       100
                                                                               4E-4
                                                                               1000
010201
DINITROBENZENE.  1.3-
     NOAEL 0.4 MG/KG/DAY
             ORAL:  DRINKING
             WATER
RAT
       000099-65-0
             SPLEEN
                INCREASED WEIGHT
                                                                       1E-3
                                                                       100
                                                                               IRIS
010471
IRIS. EPA-S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                1-45

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL    DOSE          Sf£CJ£S
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL  EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
                              (IDQ/CU m)  (ma/ko/dav)   (ITM/CU m)  (mg/ka/dav)
                                 UF         UF          UF         UF
DINITROBENZENE.  1.4-
     NOAEL 0.4 MG/KG/OAY
             ORAL:  DRINKING
             WATER
       000100-25-4
RAT   -
16 WEEKS
SPLEEN
INCREASED WEIGHT
            SUBCHRONIC [RfD] COMMENT:  DERIVED BY ANALOGY TO 1.3-DINITROBENZENE.
            CHRONIC [RfD] COMMENT:  DERIVED BY ANALOGY TO 1.3-DINITROBENZENE.
4E-3
100
4E-4       010202
1000
DINITROPHENOL.  2.3-               000066-56-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005936
DINITROPHENOL.  2.4-
     LOAEL 2 MG/KG/DAY
             ORAL
 HUMAN
       000051-28-5
             EYE
                CATARACT
                                          2E-3
                                          1000
            SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
                                                                                            IRIS
                                                                                                                IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (06/13/91) BY THE RfD/RfC WORK GROUP.
                                                                                         010438
                                                                                                      010895
DINITROPHENOL.  2.5-               000329-71-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DINITROPHENOL.  2.6-               000573-56-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005937
                                                                                                     005938
DINITROPHENOL.  3.5-               000586-11-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005939
DINITROTOLUENE.  2.3-               000602-01-7
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005940
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-46

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
               TARGET
               CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfO]       [RfC]        [RfD]     REFERENCE
(ITO/CU m)  (ma/ka/dav)   (tna/cu m)  (ina/ka/dav)
   UF         UF           UF        UF
DINITROTOLUENE.  2.4-
     NOAEL  0.2 MG/KG/DAY        DOG
             ORAL:  GELATIN    UP TO 2
             CAPSULE          YEARS
        000121-14-2
              CENTRAL NERVOUS  NEUROTOXICITY
              SYSTEM
              ERYTHROCYTES    HEINZ BODIES
              BILIARY TRACT   HYPERPLASIA
                                                          2E-3
                                                          100
                                 IRIS
                                                                                                         005941
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD IS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                                 IRIS
                                                                                                         010896
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED  NOT VERIFIABLE (12/20/90)  BY THE RfD/RfC WORK GROUP.
DINITROTOLUENE.  2.5-
            GENERAL COMMENT:
        000619-15-8
DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                          005942
DINITROTOLUENE.  2.6-
     NOAEL 4 MG/KG/DAY
             ORAL:  DIET
        000606-20-2
  GOG
 13 WEEKS
WHOLE BODY      MORTALITY
CENTRAL NERVOUS  NEUROTOXICITY
SYSTEM
BLOOD
BLOOD
BILE DUCT
KIDNEY
                                                            HEINZ BODIES
                                                            METHEMOGLOBINEMIA
                                                            HYPERPLASIA
                                                            HISTOPATHOLOGY
            CHRONIC [RfD] COMMENT:  UNDER REVIEW.  CURRENT NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DINITROTOLUENE.  3.4-
            GENERAL COMMENT:
        000610-39-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
            IE-2
            300
1E-3
3000
005943
                                                                                          005944
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                    1-47

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                              (mg/cu m) (mg/kq/dav)   (mo/cu m) (mg/ka/dav)
                                 UF         UF          UF         UF
DINOSEB
     LOAEL 1 MG/KG/DAY
             ORAL:  DIET
       000088-85-7
 RAT
29 WEEKS
FETUS
DECREASED WEIGHT
1E-3
1000
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RFD WAS ADOPTED AS THE SUBCHRONIC ORAL [RFD].
            CHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RFD WAS DETERMINED FROM A 3-GENERATION REPRODUCTION STUDY.
DIPHENYLAHINE.  N.N-
     NOEL  2.5 MG/KG/DAY        DOG
             ORAL: DIET       2 YEARS
       000122-39-4

             WHOLE BODY
             LIVER
             KIDMEY
                DECREASED WEIGHT GAIN
                INCREASED WEIGHT
                INCREASED WEIGHT
                                          2.5E-2
                                          100
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS
                     IRIS
005945
          005946
DIRECT LIGHTFAST BLUE             004399-55-7
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                       005947
DISULFOTON
     LOAEL  0.04 MG/KG/DAY       RAT
             ORAL:  DIET       2 YEARS
       000298-04-4

             EYE
             BLOOD
                DEGENERATION
                CHOLINESTERASE  INHIBITION
                                          4E-5
                                          1000
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                     IRIS
          010412
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK. INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                  1-48

-------
                                  HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN  CARCINOGENICITY)                  May 1995

                                                                                                     Subchronic           Chronic
CHEMICAL    DOSE           SPECIES                                                            [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
LEVEL       ROUTE     EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT                 (ma/cu m)  (mg/kq/dav)   (ma/cu m) (ma/ka/day)
                                                                                              UF         UF          UF         UF

ENDOSULFAN                          000115-29-7
     NOAEL 15  PPM               RAT
             ORAL: DIET        2 YEARS       WHOLE BODY       DECREASED WEIGHT GAIN                      6E-3                 IRIS       010926
                                            KIDNEY          GLOMERULONEPHROSIS                         100
                                            BLOOD VESSEL     ANEURYSMS

     NOAEL 10  PPM               DOG
             ORAL: DIET        1 YEAR        WHOLE BODY       DECREASED WEIGHT GAIN                                                      010938

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHORNIC ORAL [RfD]  BASED ON CO-CRITICAL  RAT AND DOG
                                      STUDIES.

ENDOTHALL                           000145-73-3
     NOEL  2 MG/KG/DAY          DOG
             ORAL: DIET        2 YEARS       STOMACH         INCREASED WEIGHT                           2E-2                 IRIS       005948
                                            SMALL INTESTINE  INCREASED WEIGHT                           100

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].


ENDRIN                               000072-20-8
     NOEL  0.025 MG/KG/DAY      DOG
             ORAL: DIET        2 YEARS       CENTRAL NERVOUS  CONVULSIONS                                3E-4                 IRIS       005445
                                            SYSTEM                                                     100
                                            LIVER           LESIONS

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.                    1-49

-------
                                   HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
 Cjj£MJ£Ai    DOSE          SPECIES
 LEVEL       ROUTE     EXPERIMENT LENGTH
               TARGET
 EPICHLOROHYDRIN
      LOAEL  37.8 MG/CU M
              INHALATION:
              INTERMITTENT
        000106-89-8
 RAT
 136 WEEKS     KIDNEY
                                                            CRITICAL EFFECT
LESIONS
                                         Subchronic          Chronic
                                 [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
                               (TO/CU m)  (mg/kg/dav)   (mg/cu m)  (mg/kg/dav)
                                 UF         UF           UF         UF
                                                                        2E-3
                                                                        1000
                                                                2E-3       010440
                                                                1000
             SUBCHRONIC  [RfD] COMMENT:  BASED ON ROUTE-TO-ROUTE EXTRAPOLATION. THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD]
             CHRONIC [RfD] COMMENT:  WITHDRAWN FROM  IRIS (04/01/92)
             GENERAL COMMENT:  ALSO SEE HEAST TABLE  3: CARCINOGENICITY
     NOAEL 19 MG/CU M           RAT
              INHALATION:       90 DAYS      NASAL
              INTERMITTENT                   EPITHELIUM
                              LESIONS
                                                              1E-2
                                                              100
                                                     IRIS
                                                                          010492
 EPTC
     NOEL  2.5 MG/KG/DAY
              ORAL: DIET
        000759-94-4
 RAT
2            HEART
GENERATIONS
                                                             DEGENERATIVE CARDIOMYOPATHY
                                          2.5E-2
                                          100
             SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
             CHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RFD WAS DETERMINED FROM A 2-GENERATION REPRODUCTION STUDY.
                                                                                                                            IRIS
005959
ETHOPROP                            013194-48-4
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                      005951
ETHOXYETHANOL  ACETATE, 2-
       000111-15-9
                                                                                                                                      010507
            SUBCHRONIC [RfD]  COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS  --  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ETHOXYETHANOL ACRYLATE, 2-        000106-74-1
            GENERAL COMMENT:  DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                     005953
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE   (513) 569-7254.
                                                                                                                  1-50

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
                                              CRITICAL EFFECT
ETHOXYETHANOL DODECANOATE.  2-    000106-13-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
          Subchronic          Chronic
  [RfC]      [RfD]        [RfC]       [RfD]    REFERENCE
(mq/cu m)  (na/ka/dav)   (mo/cii m) (ma/kg/dav)
   UF         UF          UF         UF
                                                                                                     005956
ETHOXYETHANOL PHOSPHATE. 2-      068554-00-7
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005955
ETHOXYETHANOL.  2-                 000110-80-5
     LQAEL  357 MG/KG/DAY        RAT
             ORAL: GAVAGE      103 WEEKS     WHOLE BODY
     NOEL   50 uL/KG/DAY         RAT
             ORAL:  GAVAGE      21 DAYS
                             DECREASED WEIGHT
                                                                       5E-1
                                                                       100
                               FETUS           SKELETAL MALFORMATIONS


SUBCHRONIC  [RfD] COMMENT:   BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS  1-21 OF GESTATION.
                                                                                                              4E-1
                                                                                                              1000
                                           005470
                                           005468
     NOAEL  380 MG/CU M          RABBIT
             INHALATION:       13 WEEKS
             INTERMITTENT
             BLOOD
                                               ALTERED HEMATOLOGY
 2E+0
 30
IRIS
010441
ETHOXYETHYL METHACRYLATE. 2-     002370-63-0
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005954
ETHYL ACETATE
     NOEL  900 MG/KG/DAY
             ORAL: GAVAGE
       000141-78-6
 RAT
90 DAYS      WHOLE BODY
             WHOLE BODY
                                               INCREASED MORTALITY
                                               DECREASED WEIGHT
            9E+0
            100
           IRIS
005957
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-51

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGEN1CITY)
                                                                                                              May  1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                              (mg/cu m) (mq/ka/dav)   (mq/cu m) (tng/kg/dav)
                                 UF         UF          UF         UF
ETHYL BENZENE
       000100-41-4
                                                                                                                 IRIS
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE  SUPERFUNO HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE  SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
ETHYL CHLORIDE
     NOAEL 1504 PPM
             INHALATION:
             INTERMITTENT
       000075-00-3
MOUSE
10 DAYS
FETUS
DEVELOPMENTAL TOXICITY
1E+1
300
            SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
            CHRONIC [RfC]  COMMENT:  BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
                                                                     IRIS
                                                                                                                            IRIS
                                                                                                       010867
                                                                                                       010866
                                                                          010371
ETHYL ETHER                         000060-29-7
     NOAEL 500 MG/KG/DAY        RAT
             ORAL: GAVAGE      90 DAYS       LIVER
                              EFFECTS
                                                          2E+0
                                                          300
                                                                                             IRIS
                                                                          010396
ETHYL METHACRYLATE                 000097-63-2
     NOEL  7.5 MG/KG/DAY        RAT
             ORAL: DRINKING    2 YEARS       KIDNEY
             WATER
                              INCREASED RELATIVE WEIGHT
                                                          9E-2
                                                          100
                                                               9E-2
                                                               100
                                          005961
            CHRONIC [RfD] COMMENT:  CALCULATED FROM METHYL METHACRYLATE DATA BY MULTIPLYING BY THE RATIO OF THE MOLECULAR WEIGHTS  (114.5/100.13).
ETHYL-0-XYLENE.  4-                 000934-80-5
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                        010472
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-52

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                               May 1995
 CHEMICAL     BQSt          SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(roa/cu m)  (ma/ka/dav)   (mg/cu m)  (ma/kQ/dav)

ETHYLANILINE. N-
GENERAL COMMENT:
ETHYLENE CYANOHYDRIN
NOEL 30 MG/KG/OAY
ORAL: DRINKING
WATER
ETHYLENE DIAHINE
NOAEL 22.6 MG/KG/OAY
ORAL: DIET

000103-69-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
000109-78-4
RAT
90 DAYS HEART DECREASED WEIGHT
BRAIN DECREASED WEIGHT
000107-15-3
RAT
3 MONTHS HEART DECREASED WEIGHT
BLOOD HEMATOLOGIC CHANGES
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE
ETHYLENE 6LYCOL
NOEL 200 MG/KG/DAY
ORAL: DIET
000107-21-1
RAT
FETUS FETOTOXICITY
UF UF UF UF

3E-1 3E-1
100 100
2E-1 2E-2
100 1000
IRIS
(12/18/90) BY THE RfD/RfC WORK GROUP.
IRIS
2E+0
100

005958
005780
005796
010898
005454
005452
            SUBCHRONIC [RfD] COMMENT:  BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
ETHYLENE  GLYCOL MONOBUTYL  ETHER      000111-76-2
     NOAEL  121 MG/CU M          RAT
             INHALATION:        13 WEEKS     BLOOD
             INTERMITTENT
               ALTERED HEMATOLOGY
                                2E-1
                                100
                      2E-2
                      1000
            CHRONIC [RfC] COMMENT:  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
010353
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE': (513) 569-7254.
                                                                                                    1-53

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                      May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET
                     CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]        [RfC]        [RfD]     REFERENCE
                               (mQ/cu m) (mo/kg/dav)   (na/cu m) (ma/kq/dav)
                                 UF         UF          UF         UF
ETHYLENE THIOUREA                  000096-45-7
     LOAEL 0.25 MG/KG/DAY       RAT
             ORAL:  DIET        24 MONTHS    THYROID
                      HYPERPLASIA
                                          8E-5
                                          3000
                     IRIS       010397
            SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

            CHRONIC [RfC] COMMENT:  THE CHRONIC  INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (08/12/92) BY THE  RfD/RfC WORK GROUP
                                                                                                010899
ETHYLTOLUENE. M-                    000620-14-4
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                               005963
ETHYLTOLUENE. 0-                    000611-14-3
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                               005962
ETHYLTOLUENE. P-                    000622-96-8
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                               005964
FLUORANTHENE
     NOAEL  125 MG/KG/DAY        MOUSE
             ORAL:  GAVAGE      90 DAYS
000206-44-0

      KIDNEY
      LIVER
      BLOOD
NEPHROPATHY
WEIGHT CHANGES
HEMATOLOGICAL CHANGES
4E-1
300
IRIS
            CHRONIC [RfC] COMMENT:  THE CHRONIC  INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP.
010168
                                                                                                010967
FLUORENE                             000086-73-7
     NOAEL 125 MG/KG/DAY        MOUSE
             ORAL:  GAVAGE      13 WEEKS      ERYTHROCYTES     DECREASED COUNTS
                                                                4E-1
                                                                300
                                                                IRIS
                                010169
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                          1-54

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                      May 1995
£HQ1I£A1     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
       TARGET
FLUORINE / (SOLUBLE  FLUORIDE)     007782-41-4
     NOAEL 0.06 MG/KG/DAY       HUMAN
             ORAL: DRINKING                 TOOTH
             WATER
CRITICAL EFFECT
                      FLUOROSIS
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(ma/cu m)  (mg/ka/dav)   (im/cu m)  (iro/kg/dav)
   UF        UF           UF         UF
                                           6E-2
                                           1
                                 IRIS
005965
FLURIDONE
     NOEL  200 PPM              RAT
             ORAL:  DIET       2 YEARS
059756-60-4

      KIDNEY
      TESTIS
      WHOLE BODY
      ORGANS
 GLOMERULONEPHRITIS
 ATROPHY
 DECREASED WEIGHT
 DECREASED WEIGHT
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
FOLPET
     NOEL  10 MG/KG/DAY         DOG
             ORAL: CAPSULE     1 YEAR
000133-07-3

      WHOLE BODY
      BLOOD
 ALTERED WEIGHT GAIN
 ALTERED CHEMISTRY
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
FORMALDEHYDE
     NOAEL  15 MG/KG/DAY         RAT
             ORAL:  WATER      2 YEARS
000050-00-0
      GASTRO-          LESIONS
      INTESTINAL TRACT
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      8E-2
                                                                                                      100
                                                                                                      1E-1
                                                                                                      100
                                                                                                      2E-1
                                                                                                      100
                                 IRIS
                                 IRIS
                                                                IRIS
005966
005967
                                           010398
FORMALDEHYDE CYANOHYDRIN          000107-16-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                               005782
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                          1-55

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT  LENGTH
              TARGET
                CRITICAL EFFECT
                                                               [RfC]
                                                         Subchronic
                                                            [RfD]
                                                            Chronic
                                                       [RfC]        [RfD]
                                            REFERENCE
                               (mg/cu m)  (mg/kg/dav)   (mg/cu m)  (mg/ka/dav)
                                  UF         UF           UF        UF
FORMIC ACID
     NOAEL 200 MG/KG/DAY
             ORAL: WATER
        000064-18-6
 RAT
MULTI-
GENERATION
WHOLE BODY
DECREASED GROWTH
           2E+0
           100
            CHRONIC [RfD] COMMENT:   BASED ON A MULTI-GENERATION  STUDY. WITHDRAWN FROM IRIS (12/01/90). UNDER REVIEW.
                             CURRENT NUMBER SUBJECT TO CHANGE.
                     2E+0
                     100
                     010268
FURAN
     NOAEL 1.4 MG/KG/DAY
             ORAL: GAVAGE
        000110-00-9
 MOUSE
13 WEEKS
LIVER
LESIONS
           1E-2
           100
                      IRIS
                     005462
FURFURAL
     LOAEL 7.9 MG/KG/DAY
             ORAL: GAVAGE
        000098-01-1
 RAT
13 WEEKS
LIVER
HEPATOTOXICITY
           3E-2
           300
                      IRIS
                     005466
            SUBCHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
            CHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
GLYCIDALDEHYDE
     NOAEL 29 MG/CU M
              INHALATION:
              INTERMITTENT
        000765-34-4
 RAT
12 WEEKS
WHOLE BODY
KIDNEY
DECREASED WEIGHT
EFFECTS
1E-2
300
4E-3
300
            SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE  EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5
            CHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION  FACTOR OF 0 5.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1E-3
3000
IRIS
005968
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                   1-56

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET
                             CRITICAL EFFECT
                                                        Subchronlc          Chronic
                                                 [RfC]      [RfD]        [RfC]       [RfD]     REFERENCE
                                               (mg/cii m) (mg/kg/dav)   (ma/cu m)  (iro/kg/day)
                                                 UF         UF          UF         UF
HEPTACHLOR                          000076-44-8
     NOEL  0.15 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS       LIVER
                              INCREASED WEIGHT
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY
HEPTACHLOR EPOXIDE                 001024-57-3
     LOAEL 0.0125 MG/KG/DAY     DOG
             ORAL:  DIET        60 WEEKS      LIVER
                              INCREASED RELATIVE WEIGHT
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                          5E-4
                                                          300
                                                           1.3E-5
                                                           1000
                                                               IRIS       005506
                                                                IRIS
                                010399
HEPTANE.  N-                         000142-82-5
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      005969
HEXABROMOBENZENE
     NOAEL 2 MG/KG/DAY
             ORAL: DIET
       000087-82-1
 RAT
12 WEEKS
LIVER
INDUCED CARBOXYLESTERASE
ACTIVITY
2E-2
100
                                                                                                                            IRIS
005970
HEXACHLOROBENZENE
       000118-74-1
                                                                                                                            IRIS
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED  NOT VERIFIABLE (11/15/90)  BY THE RfD/RfC WORK GROUP.

            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE  SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
                                                                                                       010868
                                                                                                       010900
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-57

-------
                                 HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
(mq/cii m)  (mg/kg/dav)   (ma/cu m)  (mg/kg/dav)
   UF         UF           UF         UF
HEXACHLOROBUTADIENE
     LOAEL 0.5 MG/KG/DAY
             ORAL:  DIET
       000087-68-3
MOUSE
13 WEEKS
RENAL TUBULES    REGENERATION
            CHRONIC  [RfD] COMMENT:  WITHDRAWN FROM IRIS (05/01/93). UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
            SUBCHRONIC [RfD] COMMENT:   CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
                                 2E-4       010927
                                 1000
HEXACHLOROCYCLOHEXANE.  DELTA-   000319-86-8
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      010495
HEXACHLOROCYCLOHEXANE.  EPSRON-     006108-10-7
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      010496
HEXACHLOROCYCLOHEXANE.  GAMMA-   000058-89-9
     NOAEL 0.33 MG/KG/DAY       RAT
             ORAL:  DIET        12 WEEKS      LIVER
                                           KIDNEY
                             TOXICITY
                             TOXICITY
                                                          3E-3
                                                          100
                                 IRIS
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

            CHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION  [RfC] IS CONSIDERED NOT VERIFIABLE (05/27/92) BY THE RfD/RfC WORK GROUP.
005537
                                                                                                      010903
HEXACHLOROCYCLOPENTADIENE        000077-47-4
     NOAEL 7.1 MG/KG/DAY        RAT
             ORAL             13 WEEKS      FORESTOMACH     LESIONS
                                                                       7E-2
                                                                       100
                                                                               IRIS
     NOAEL 0.15 PPM             RAT
             INHALATION:       13 WEEKS
             INTERMITTENT
             NASAL CAVITY     SQUAMOUS METAPLASIA
                                               7E-4
                                               100
                      7E-5
                      1000
                                           005299
010445
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE  (513) 569-7254
                                                                                                                 1-58

-------
                                   HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                                 May  1995
              BQSI          SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL  EFFECT
 HEXACHLOROETHANE                   000067-72-1
      NOAEL 1  MG/KG/DAY          RAT
              ORAL: DIET       16 WEEKS      KIDNEY           DEGENERATION
                                                                                         Subchronic          Chronic
                                                                                 [RfC]      [RfO]       [RfC]        [RfD]     REFERENCE
                                                                               (mq/cu m)  Imq/kQ/dav)   (mq/cu m)
                                                                                  UF
UF
                                                                                                       1E-2
                                                                                                       100
                                                                                                         UF
                                                                                                                                UF
                                                                                                                IRIS       005518
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

             CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT  VERIFIABLE (11/05/92).  BY THE RfD/RfC WORK GROUP.
 HEXACHLOROPHENE
      LOAEL 0.75 MG/KG/DAY       DOG
              ORAL:  DIET        13 WEEKS
                          000070-30-4
                                NERVOUS SYSTEM   EFFECTS
                                                                                                       3E-3
                                                                                                       300
                                                                                                               IRIS
 HEXAMETHYLENE DIAMINE             000124-09-4
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
 HEXANE.  N-
     LOAEL 570 MG/KG/DAY
             ORAL
                          000110-54-3
     LOAEL 73 MG/CU M
              INHALATION:
              INTERMITTENT
                   RAT
                   HUMAN
                                            NERVOUS SYSTEM   NEUROPATHY
                                            TESTIS           ATROPHY
                               NERVOUS SYSTEM   NEUROTOXICITY


SUBCHRONIC  [RfC] COMMENT:   THE  CHRONIC INHALATION  RfC WAS ADOPTED AS THE  SUBCHRONIC INHALATION [RfC]


2E-1
300
6E-1
1000
IRIS

6E-2
10000


HEXANONE.  2-                        000591-78-6
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                          010904
                             005972
                                                                                                                                     005973
                                                                                                                          005974
                             010273
                                                                                                                                     005976
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                1-59

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH      TARGET
                             CRITICAL EFFECT
                                        Subchronic          Chronic
                                 [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                               (mg/cu m) (ma/kq/dav)   (ma/cu m)  (ma/kq/dav)
                                 UF         UF           UF         UF
HYDROGEN  SULFIDE
     NOAEL  3.1 MG/KG/DAY
             ORAL:  FOOD
       007783-06-4
 PIG
105 DAYS      GASTRO-         DISTURBANCE
             INTESTINAL SYSTEM
     NOAEL 42 MG/CU M           MOUSE
             INHALATION:       13 WEEKS      NASAL MUCOSA     INFLAMMATION
             INTERMITTENT
                                                             9E-3
                                                             100
                                          3E-2
                                          100
                                                     IRIS
                     IRIS       010269
                                010354
HYDROOJJINONE
     NOAEL 4.29 MG/KG/DAY
             ORAL
       000123-31-9
 HUMAN
3-5 MONTHS    BLOOD
HEMATOLOGICAL EFFECTS
4E-1
10
                                                                                                                 IRIS
4E-2
100
            CHRONIC RfC  COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (10/01/90) BY THE RfD/RfC WORK GROUP.
005526


010905
IRON                                 007439-89-6
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ISOBUTYL ALCOHOL
     NOEL  316 MG/KG/DAY        RAT
             ORAL:  GAVAGE      13 WEEKS
       000078-83-1
             NERVOUS SYSTEM  HYPQACTIVITY
             NERVOUS SYSTEM  ATAXIA
                                           3E+0
                                           100
                      IRIS
                                                                                                       005527
           005977
ISOPHORONE                          000078-59-1
     NOEL   150 MG/KG/DAY        DOG
             ORAL:  CAPSULE     90 DAYS       KIDNEY
                             LESIONS
                                           2E+0
                                           100
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                      IRIS
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/15/90) BY THE RfD/RfC WORK GROUP.
           005910
                                                                                                        010906
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE.  (513) 569-7254.
                                                                                                                  1-60

-------
LEVEL
ROUTE
                           fnr^,rr-
                           SPECIES
                      EXPERIMENT LENGTH
                                   HEAST  TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)



                                             TARGET         CRITICAL EFFECT
 ISOPROPALIN
      NOEL  15 MG/KG/DAY         RAT
              ORAL: DIET       90 DAYS
033820-53-0

      BLOOD
      ORGANS.
      UNSPECIFIED
                                                            HEMATOLIGICAL EFFECTS
                                                            ALTERED WEIGHTS
lUIHtK

[RfC]
(ma/cu n
UF
IHAN CARCINO
Subchronic
[RfD]
i) (ma/ka/dav)
UF
GENICITY)
Chronic
[RfC] [RfD]
(ma/cu m) (ma/ka/da1
UF UF
May 1995

REFERENCE
/>

                                                                                          1 5E-1
                                                                                          100
                                                                                                                             IRIS
                                                                                                                                       005978
 LACTONITRILE                        000078-97-7
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                      005783
LEAD                                 007439-92-1

            ruR™IC CRfC] COtt1ENT:   REFER T0 APPENDIX A:  TECHNICAL INFORMATION.  SECTION  V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
            CHRONIC [RfD] COMMENT:   REFER TO IRIS
            GENERAL COMMENT:  ALSO  SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                                                       010447
 LEAD ALKYLS
             CHRONIC  [RfC] COMMENT:  REFER TO APPENDIX A:  TECHNICAL  INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
             CHRONIC  [RfD] COMMENT:  REFER TO IRIS
             GENERAL  COMMENT:  DIMETHYLETHYL LEAD; METHYLTRIETHYL  LEAD; TETRABUTYL LEAD: TETRAETHYL LEAD  TETRAMETHYL LEAD-
                              TETRAPROPYL LEAD: TRIETHYL      LEAD:  TRIMETHYL LEAD: TRIMETHYLETHYL LEAD: TRIPROPYL LEAD
                                                                                                                                       010448
LINURON                              000330-55-2
     LOAEL  0.625 MG/KG/DAY      DOG
             ORAL: DIET       2 YEARS       BLOOD
                                                             HEMATOLOGICAL EFFECTS
                                                                                          2E-3
                                                                                          300
                                                                                                                            IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                                                       005990
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET
                            CRITICAL EFFECT
                                                        Subchronic          Chronic
                                                [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                              (mq/cu m)  (ma/ka/dav)   (mq/cu ml (ma/ka/dav)
                                                 UF         UF           UF        UF
MALATHION                            000121-75-5
     NOEL  0.23 MG/KG/DAY       HUMAN
             ORAL:  CAPSULE     47 DAYS      BLOOD
                             HEMATOLOGICAL EFFECTS
            SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            CHRONIC [RfC] COMMENT:  UNDER REVIEW.
HALE1C ANHYDRIDE                   000108-31-6
     NOAEL  10 MG/KG/DAY         RAT
             ORAL:  DIET       2 YEARS       KIDNEY
                             LESIONS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
MALEIC HYDRAZIDE
     LOAEL  500 MG/KG/DAY
             ORAL:  DIET
       000123-33-1
 RAT
28 MONTHS     KIDNEY
                ALTERED  FUNCTION
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                          2E-2
                                                          10
                                                          1E-1
                                                          100
                                          5E-1
                                          1000
                                                                                            IRIS       005991
                                                                                            IRIS
                                                                               IRIS
                                                                          005992
                                005993
HALONONITRILE
     LOAEL 0.21 MG/KG/DAY
             ORAL: GAVAGE
       000109-77-3
 RAT
120 DAYS
LIVER
SPLEEN
EFFECTS
EFFECTS
2E-4
1000
2E-5       005994
10000
NANCOZEB
     NOEL  2.9 MG/KG/DAY
             ORAL: DIET
       008018-01-7
 RAT
90 WEEKS
THYROID
GOITROGENIC  EFFECTS
3E-2
100
3E-2
100
                                                                                          005995
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-62

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN  CARCINOGENICITY)
 CHEMICAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 MANEB                                012427-38-2
      NOEL  5 MG/KG/DAY          MONKEY
              ORAL:  DIET        6 MONTHS      THYROID
CRITICAL EFFECT
                              INCREASED WEIGHT
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]
(mq/cu m)  (mg/kq/dav)   (TO/CU m) (mq/kg/dav)
   UF         UF           UF         UF
                                                                                                               May 1995


                                                                                                           REFERENCE
                                                                                                        5E-2
                                                                                                        100
                                                                                              IRIS
                                                                            005996
 MANGANESE
     NOAEL 0.005 MG/KG/DAY      HUMAN
              ORAL: DRINKING    CHRONIC
              WATER
        007439-96-5
              CENTRAL NERVOUS  EFFECTS
              SYSTEM
                                            5E-3
                                            1
             SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL WATER RfD WAS ADOPTED AS THE SUBCHRONIC ORAL WATER [RfD]
                              SEE IRIS FOR SPECIFIC DIETARY INFORMATION.
     NOAEL 0.14 MG/KG/DAY       HUMAN
             ORAL: DIET        CHRONIC
             CENTRAL NERVOUS  EFFECTS
             SYSTEM
                                                                                                        1.4E-1
                                                                                                        1
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL FOOD RfD WAS ADOPTED AS THE SUBCHRONIC ORAL FOOD  [RfD]
                              SEE IRIS  FOR SPECIFIC DIETARY INFORMATION.

            SUBCHRONIC [RfC] COMMENT:   A SUBCHRONIC [RfC] HAS NOT BEEN DERIVED FOR MANGANESE.
                                 IRIS
010850
                                                                 IRIS
                                                                                    IRIS
                                            010851
                                                                            010959
HEPHOSFOLAN
     NOEL  0.09 MG/KG/DAY
             ORAL: DIET
       000950-10-7
 RAT
17 WEEKS
                                            LIVER
                                            KIDNEY
                                            BLOOD

                                            ERYTHROCYTES

                                            BRAIN
ALTERED WEIGHT
ALTERED WEIGHT
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
                                                                         9E-4
                                                                         100
                                 9E-5
                                 1000
005997
MS.  EPA-S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                   1-63

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
CHEMICAL    DOSE
LEVEL       ROUTE     EXPERIMENT LENGTH
                                            TARGET
MERCURIC  CHLORIDE
                               RAT
             ORAL: PARENTERAL
                                      007487-94-7
                                            KIDNEY
CRITICAL EFFECT
 AUTOIMMUNE  EFFECTS
                                                                                                     Subchronic           Chronic
                                                                                             [RfC]      [RfD]       [RfC]       [RfD]
                                                                                           (ma/cu m)  (ma/ko/dav)   (mq/cu m)  (mQ/ko/dav)
                                                                                  May 1995


                                                                             REFERENCE
                                                                                              UF
                                                                                                         UF
3E-4
 1000
                                                          UF
                                                                                                                                UF
                                                                                                                            IRIS
MERCURY.  ELEMENTAL
     NOAEL 0.009 MG/CU M
             INHALATION:
             SUBCHRONIC [RfD] COMMENT: THE CHRONIC  ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].

                                     007439-97-6
                               HUMAN
                                            NERVOUS  SYSTEM   NEUROTOXICITY
                                 3E-4
                                 30
            3E-4
            30
            CHRONIC [RfC] COMMENT:  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.

                                      000150-50-5
MERPHOS
     NOEL   0.1 MG/KG/DAY        HEN
             ORAL: CAPSULE     3  MONTHS
                                            NERVOUS SYSTEM  ATAXIA
                                            NERVOUS SYSTEM  DELAYED NEUROTOXICITY
                                            WHOLE BODY      DECREASED WEIGHT
                                            3E-4
                                            300
                                                                                                                             IRIS
             CHRONIC [RfC] COMMENT:   THE  CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP.
             SUBCHRONIC [RfD] CPMMENT:  THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
MERPHOS OXIDE                      000078-48-8
     NOEL  0.1 MG/KG/DAY        HEN
              ORAL: CAPSULE     3 MONTHS
                                            NERVOUS SYSTEM   ATAXIA
                                            NERVOUS SYSTEM   DELAYED NEUROTOXICITY
                                            WHOLE BODY      DECREASED WEIGHT
                                            3E-4
                                            300
                                                                                                                             IRIS
             CHRONIC  [RfC] COMMENT-  THE CHRONIC  INHALATION [RfC] IS  CONSIDERED NOT VERIFIABLE (06/25/92)  BY THE RfD/RfC WORK GROUP.
             SUBCHRONIC [RfO] CPMMENT:  THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL  [RfD].
                                                                                                                                      005800
                                                                                                                                       010270
                                 005998
                                                                                                                                       010907
                                 005999
                                                                                                                                        010908
 IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                  1-64

-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) May 1995

PHFMirAi IYKC cornrc Subchronic Chronic
InbflllAl. ELSE. SPECIES rRfc-i rRfD-| rRfC1 rRfm RFFFRFNCT
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT cLi.l C/Sdav) (la/cu .) (JkSL
UF UF UF UF

METHACRYLONITRILE 000126-98-7
NOAEL 3.2 PPM DOG
INHALATION: 90 DAYS LIVER INCREASED SGOT l£-3 IRIS 005812
INTERMITTENT LIVER INCREASED SGPT 300
CENTRAL NERVOUS LOSS OF HINDLIMB MOTOR CONTROL
SYSTEM
BRAIN LESIONS

-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DQSI SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (ma/ka/dav) (ma/cu m) (ma/kq/dav)
UF UF UF UF
METHOXYCHLOR 000072-43-5
NOEL 5.01 MG/KG/DAY RABBIT
ORAL: GAVAGE 13 DAYS REPRODUCTION LOSS OF LITTERS

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
5E-3
1000
IRIS
IRIS 010357
010909
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/07/91) BY THE RfD/RfC WORK GROUP.

METHOXYETHANOL ACETATE. 2- 000110-49-6

CHRONIC [RfO] COMMENT- ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHOXYETHANOL. 2-
NOAEL 93 MG/CU M
INHALATION:
INTERMITTENT
000109-86-4
RABBIT
13 WEEKS
TESTICLE
EFFECTS
2E-1
100
IRIS
010372
SUBCHRONIC [RfD] COMMENT- ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
METHYL ACETATE
NOEL 1156 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000079-20-9

LIVER
LIVER
INCREASED ALKALINE PHOSPHATASE
INCREASED SGPT
1E+1
100
1E+0
1000
010002
CHRONIC [RfD] COMMENT: CALCULATED FROM DATA OBTAINED WITH METHANOL BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (74.08/32.04).
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-66
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL J2QS£ SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ing/cu m) dnq/ko/dav) (mo/cu m) (mo/kg/day)
UF UF UF UF
METHYL ACRYLATE 0000%-33-3
010498
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

METHYL CHLOROCARBONATE 000079-22-1
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (05/01/89).
GENERAL COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
METHYL ETHYL KETONE 000078-93-3
NOAEL 1711 MG/KG/DAY RAT
ORAL: DRINKING MULTI- FETUS
WATER GENERATION
DECREASED BIRTH WEIGHT
2E+0
1000
IRIS
010853
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT: MULTI-GENERATION DEVELOPMENTAL STUDY PERFORMED WHT THE SURROGATE 2-BUTANOL. A METABOLITE OF METHYL ETHYL KETONE.
NOAEL 1010 PPM MOUSE
INHALATION: 10 DAYS
INTERMITTENT
FETUS
1E+0
3000
DECREASED BIRTH WEIGHT

SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
IRIS
010845
METHYL ETHYL KETONE PEROXIDE 001338-23-4
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
010948
IRK. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-67
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(mq/cu m) (mci/ka/dav)
UF UF
Chronic
[RfC] [RfD]
(na/cu m) (ina/kq/dav)
UF UF
REFERENCE
METHYL ISOBUTYL KETONE
NOAEL 250 MG/(KG-DAY)
ORAL: GAVAGE
000108-10-1
RAT
13 WEEKS
WHOLE BODY
LIVER

LIVER

KIDNEY

KIDNEY
LETHARGY
INCREASED RELATIVE WEIGHT IN
FEMALES
INCREASED ABSOLUTE WEIGHT IN
FEMALES
INCREASED RELATIVE WEIGHT IN
FEMALES
INCREASED ABSOLUTE WEIGHT IN
FEMALES
INCREASED URINARY PROTEIN
LEVELS IN FEMALES
8E-1
300
8E-2 010949
3000
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (03/01/91). UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
METHYL ISOCYANATE
000624-83-9
IRIS
010013
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/18/90) BY THE RfD/RfC WORK GROUP.
METHYLMERCURY
CRITICAL ORAL DOSE
0.001 MG/KG/DAY
022967-92-6
HUMAN
DEVELOPMENTAL NEUROLOGICAL ABNORMALITIES
IN HUMAN INFANTS
1E-4
IRIS
010970
10
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: A BENCHMARK DOSE APPROACH WAS USED RATHER THAN A NOAEL/LOAEL TO DERIVE THE RfD.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-68
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL BQSI SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
METHYL METHACRYLATE
NOEL 7.5 MG/KG/OAY
ORAL: WATER
METHYL PARATHION

NOAEL 2.5 PPM
ORAL: DIET
000030-62-6
RAT
24 MONTHS KIDNEY
RAT
90 DAYS
CRITICAL EFFECT
INCREASED RELATIVE WEIGHT

000298-00-0

ERYTHROCYTES CHOLINESTERASE INHIBITION
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (iro/cu m) (mQ/kq/dav)
UF UF UF UF
8E-2
100
2E-3
100
8E-2
100
IRIS
010014

010015

010846
METHYL STYRENE (MIXED ISOMERS) 025013-15-4

CHRONIC [RfD] COMMENT: UNDER REVIEW. ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
' 010500
METHYL STYRENE. ALPHA
000098-83-9
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010499
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID. 4-(2
NOEL 12 MG/KG/DAY RAT
ORAL: DIET
ORAL: DIET
000094-81-5
13 WEEKS

DOG
13 WEEKS

LIVER
KIDNEY

LIVER
KIDNEY
EFFECTS
EFFECTS

EFFECTS
EFFECTS
1E-1
100
IRIS
010008
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-69
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
METHYL-4-CHLOROPHENOXY) PROPIONIC ACID. 2-(2- 000093-65-2
NOEL 3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS KIDNEY ALTERED WEIGHT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (ino/ka/dav) (ma/cu m) (ma/ka/day)
UF UF UF UF
1E-2
300
IRIS
010009
METHYL-4-CHLOROPHENOXYACETIC ACID. 2- 000094-74-6
NOEL 0.15 MG/KG/DAY DOG
ORAL: DIET 52 WEEKS KIDNEY EFFECTS
LIVER EFFECTS

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
5E-4
300
IRIS
010007
METHYLCYCLOHEXANE
NOAEL 287 MG/CU M
INHALATION:
INTERMITTENT
RAT
1 YEAR
000108-87-2

KIDNEY
KIDNEY
MINERALIZATION
PAPILLARY HYPERPLASIA
3E+0
100
3E+0
100
010431
HETHYLENE BROMIDE
000074-95-3
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010501
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-70
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mq/cu m) (ma/kg/dav) (no/cu m) (ma/kg/dav)
UF UF UF UF
HETHYLENE CHLORIDE (DICHLOROHETHANE)
NOAEL 5.85 MG/KG/DAY RAT
ORAL: DRINKING 24 MONTHS LIVER
WATER
000075-09-2

TOXICITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
NOAEL 694.8 MG/CU M RAT
INHALATION: 2 YEARS
INTERMITTENT
LIVER
TOXICITY
3E+0
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
METHYLENE-BIS(2-CHLOROANILINE). 4.4'- 000101-14-4
LOAEL 7.3 MG/KG/DAY DOG
ORAL 9 YEARS LIVER EFFECTS
BLADDER EFFECTS
6E-2
100
7E-4
10000
3E+0
100
IRIS
7E-4
10000
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE 02/10/93) BY THE RfD/RfC WORK GROUP.
METHYLENEDIPHENYL ISOCYANATE. 4.4- (DIPHENYLMETHANE DIISOCYANATE) 000101-68-8
NOAEL 0.2 MG/CU M RAT
INHALATION: 24 MONTHS NASAL CAVITY LESIONS . 2E-5
INTERMITTENT 300
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC ON IRIS WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
005553
005552
010413
010933
010449
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-71
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) May 1995

Subchronic Chronic
CHEMICAL DQSI SPECIES [RfC] [RfO] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mq/cu m) (mq/kQ/dav) (rna/cu m) (mg/kg/dav)
UF UF UF UF

METOLACHLOR 051218-45-2
NOAEL 300 PPM RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 1.5E-1 1.5E-1 010950
100 100

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THC SUCHRONIC ORAL [RfD].

METRIBUZIN 021087-64-9
NOAEL 100 PPM DOG
ORAL: DIET 2 YEARS LIVER EFFECTS IRIS 010928
KIDNEY EFFECTS
WHOLE BODY MORTALITY
WHOLE BODY DECREASED WEIGHT

SUBCHRONIC [RfD] COMMENT: THE SUBCHRONIC ORAL [RfD] WAS REMOVED BECAUSE THE CHRONIC ORAL RfD UPON WHICH IT WAS BASED IS
UNDER REVIEW BY THE RfD/RfC WORK GROUP.
CHRONIC RfD COMMENT: THE CHRONIC ORAL RfD. WHILE STILL ON IRIS. IS BEING RECONSIDERED BY THE RfD/RfC WORK GROUP.

HIREX 002385-85-5
NOAEL 0.07 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER CYTOMEGALY 2E-4 IRIS 010841
LIVER FATTY METAMORPHOSIS 300
LIVER ANGIECTASIS
THYROID CYSTIC FOLLICLES

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 1-72
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENJCITY)
May 1995
CHEMICAL fiQSI SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (na/ka/dav) (mg/cu m) (ma/ka/dav)
UF UF UF UF
MOLINATE 002212-67-1
NOEL 0.2 MG/KG/DAY RAT
ORAL: GAVAGE REPRODUCTIVE TOXICITY
SYSTEM

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY.
2E-3
100
IRIS 010017
MOLYBDENUM
LOAEL 0.14 MG/KG/DAY
ORAL: WATER.
DIET
HUMAN
007439-98-7

URINE
JOINTS
BLOOD
INCREASED URIC ACID
PAIN. SWELLING
DECREASED COPPER LEVELS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RFD].

010599-90-3
MONOCHLORAMINE
NOAEL 9.5 MG/KG/OAY RAT
ORAL: DRINKING 2 YEARS
WATER
WHOLE BODY
LIVER
KIDNEY
WEIGHT CHANGES
WEIGHT CHANGES
WEIGHT CHANGES
5E-3
30
1E-1
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

NAPHTHALENE 000091-20-3
CHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
IRIS
IRIS
010489
010517
NAPHTHOQUINONE. 1.4- 000130-15-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

NICKEL CYANIDE 000557-19-7
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP.
010020
010953
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-73
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
NICKEL. SOLUBLE SALTS
NOAEL 100 PPM RAT
ORAL: DIET 2 YEARS
VARIOUS
WHOLE BODY
ORGANS. MAJOR
CRITICAL EFFECT
DECREASED WEIGHT
DECREASED WEIGHT
Subchronic
[RfC] [RfD]
(mq/cu m) (mq/ka/dav)
UF UF
2E-2
300
Chronic
[RfC] [RfO]
(mg/cu m) (mg/kq/day)
UF UF
REFERENCE
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS DERIVED FROM NICKEL MOIETY OF ADMINISTERED NICKEL CHLORIDE.
005579
NICOTINONITRILE 000100-54-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005584
NITRIC OXIDE
010102-43-9
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD HAS BEEN PERMANENTLY WITHDRAWN (09/01/94) FROM IRIS.
010451
NITRITE
NOEL 10 PPM
ORAL: WATER
HUMAN
014797-65-0
BLOOD
METHEMOGLOBINEMIA
1E-1
10
IRIS
SUBCHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN
POPULATION (INFANTS). THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN POPULATION (INFANTS).
010021
NITROANILINE. 2- 000088-74-4

CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RFD] IS CONSIDERED NOT VERIFIABLE (06/23/92) BY THE RFD/RFC WORK GROUP.
LOAEL 9.8 MG/CU M RAT
INHALATION: 4 WEEKS
INTERMITTENT
BLOOD
HEMATOLOGICAL EFFECTS
2E-3
1000
2E-4
10000
010936
010935
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-74
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHEMICAL fiQSI SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
May 1995
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(mq/cu m) (ma/kq/dav)
UF UF
NITROANILINE. N- 000099-09-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
Chronic
[RfC] [RfD] REFERENCE
(im/cu m) (ma/kQ/dav)
UF UF
010400
NITROANILINE. P-
GENERAL COMMENT:

NITROBENZENE
LOAEL 25 MG/CU M
INHALATION:
INTERMITTENT
INHALATION:
INTERMITTENT
000100-01-6
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
MOUSE
90 DAYS
000098-95-3

BLOOD
ADRENAL
KIDNEY
LIVER
RAT
90 DAYS
BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
5E-3
1000
IRIS
010024
005589
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS SUBCHRONIC AND CHRONICTOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: THE ORAL RFD. WHILE STILL AVAILABLE ON IRIS. IS BEING RECONSIDERED BY THE RFD WORKGROUP BASED ON ROUTE
TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
NITROFURANTOIN
NOAEL 300 PPM
ORAL: DIET
000067-20-9
MOUSE
13 WEEKS
TESTIS
DAMAGE
7E-1
100
7E-2
1000
005593
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-75
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL EQSI SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mq/kq/dav) (mq/cu m) (mq/kq/dav)
UF UF UF UF
NITROGEN DIOXIDE 010102-44-0
CHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfO HAS BEEN PERMANENTLY WITHDRAWN (09/01/94) FROM IRIS
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
010402
010912
NITROGEN OXIDES
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
010170
NITROHETHANE 000075-52-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010026
NITROPHENOLS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005594
NITROPROPANE. 2-
LOAEL 78 MG/CU M
INHALATION:
INTERMITTENT
000079-46-9
RAT
22 MONTHS LIVER
LESIONS
2E-2
1000
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
010374
NITROSODIPHENYLAMINE. P- 000156-10-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010027
NITROTOLUENE. M-
LQAEL 200 MG/KG/DAY
ORAL: GAVAGE
000099-08-1
RAT
6 MONTHS
SPLEEN
LESIONS
1E-1
1000
SUBCHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
CHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
1E-2
10000
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
010029
1-76
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
QW2L DQSt SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
NITROTOLUENE. 0- 000088-72-2
LOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 6 MONTHS SPLEEN
CRITICAL EFFECT
LESIONS
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(im/cu m) (ma/ka/dav) (mq/cu m) (mg/kg/dav)
UF OF OF UF
1E-1
1000
1E-2
10000
010028
NITROTOLUENE. P-
LOAEL 200 MG/KG/DAY
ORAL: GAVAGE
RAT
6 MONTHS
000099-99-0
SPLEEN
LESIONS
SUBCHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH 0-NITROTOLUENE
CHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
1E-1
1000
1E-2 010030
10000
OCTABROMOOIPHENYL ETHER 032536-52-0
NOAEL 2.5 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER

OCTAMETHYLPYROPHOSPHORAMIDE 000152-16-9
NOAEL 0.02 MG/KG/OAY HUMAN
ORAL AT LEAST 30 BLOOD
DAYS
HISTOLOGICAL CHANGES
DECREASED CHOLINESTERASE
ACTIVITY
3E-2
100
2E-3
10
IRIS
2E-3
10
010032
010031
OSMIUM TETROXIDE 020816-12-0
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
010954
OZONE 010028-15-6
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
010171
PARALOEHYDE 000123-63-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
010033
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
1-77
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DQSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mq/cu Hi) (mq/kq/dav) (ma/cu m) (ma/ka/dav)
UF UF UF UF
PARATHION
NOAEL 0.064 MG/KG/DAY
ORAL
000056-38-2
HUMAN
CHOLINESTERASE DECREASED CHOLINESTERASE
ACTIVITY
6E-3
10
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
6E-3
10
005598
PARTICULATE MATTER
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
010034
PEBULATE
NOEL 5 MG/KG/DAY
ORAL: DIET
001114-71-2
RAT
SUBCHRONIC BLOOD
INCREASED CLOTTING TIME
5E-2
100
5E-2
100
010036
PENDIMETHALIN 040487-42-1
NOEL 12.5 MG/KG/DAY DOG
ORAL: CAPSULE 2 YEARS LIVER
EFFECTS
4E-2
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS
010037
PENTABROMOOIPHENYL ETHER 032534-81-9
NOAEL 1.8 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER
ALTERED ENZYME ACTIVITIES
2E-2
100
IRIS
010038
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-78
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL CQSi SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (ma/ko/dav) (n»/cu m) (na/kq/day)
UF UF UF UF
PENTACHLOROBENZENE
LOAEL 8.3 MG/KG/DAY
ORAL: DIET
000608-93-5
RAT
100 DAYS
LIVER
KIDNEY
TOXICITY
TOXICITY
8E-3
1000
IRIS
010039
PENTACHLOROCYCLOPENTAOIENE 025329-35-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005302
PENTACHLORONITROBENZENE 000082-68-8
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER
TOXICITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PENTACHLOROPHENOL 000087-86-5
NOEL 3 MG/KG/DAY RAT
ORAL: GAVAGE 62 DAYS FETUS
FETOTOXICITY
3E-3
300
3E-2
100
IRIS
IRIS
010040
005600
SUBCHRONIC [RfD] COMMENT: BASED ON A TERATOLOGY STUDY WITH EXPOSURE 62 DAYS PRIOR TO MATING AND THROUGHOUT GESTATION AND LACTATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PENTACHLOROPROPENE. 1.1.2.3.3.- 001600-37-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010041
PENTANE. N- 000109-66-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005603
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-79
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL
LEVEL
ROUTE
SPECIES
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mq/ka/dav) (mg/cu m) (ma/kg/dav)
UF UF UF UF
PHENANTHRENE 000085-01-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP.
005604
PHENOL
NOAEL 60 MG/KG/DAY
ORAL: GAVAGE
RAT
000108-95-2
FETUS
DECREASED WEIGHT
6E-1
100
IRIS
SUBCHRONIC [RfD] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION. THE ORAL
CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.

IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (02/22/90) BY THE RfD/RfC WORK GROUP
005824
010913
PHENYLENEDIAHINE. M- 000108-45-2
NOEL 6 MG/KG/DAY RAT
ORAL 90 DAYS LIVER
LESIONS
6E-2
100
IRIS
010044
PHENYLENEDIAMINE. 0- 000095-54-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
010042
PHENYLENEDIAMINE. P-
NOAEL 18.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000106-50-3
WHOLE BODY
EFFECTS
1.9E-1
100
010043
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-80
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
PHENYLMERCURIC ACETATE 000062-38-4
NOAEL 0.0084 MG/KG/DAY RAT
ORAL: DIET 2 YEARS KIDNEY DAMAGE
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/ka/dav) (mo/cu m) (mq/kq/dav)
UF UF UF UF
8E-5
100
IRIS 010277
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]. CALCULATED BY ANALOGY TO MERCURY BY CORRECTING
FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO MERCURY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
PHORATE
NOAEL 0.033 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS
000298-02-2
CHOLINESTERASE INHIBITION
2E-4
200
2E-4 010403
200
PHOSGENE
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000075-44-5
IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (10/01/90) BY THE RfD/RfC WORK GROUP.
010045
PHOSPHINE 007803-51-2
NOEL 0.026 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
3E-4
100
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]

KIDNEY RENAL EFFECTS
NOAEL 1.4 MG/CU M
INHALATION:
INTERMITTENT
RAT
24 WKS
3E-4
1000
3E-5
10000
010174
010173
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-81
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
PHOSPHORUS. WHITE 007723-14-0

GENERAL COMMENT: FORMERLY LISTED AS PHOSPHORUS (INORGANIC COMPOUNDS).
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (ma/ka/dav) (ma/cu m) (mQ/ka/dav)
UF UF UF UF
IRIS
010452
PHOTOCHEMICAL OXIDANTS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
010172
PHTHALIC ACID. M- 000121-91-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010047
PHTHALIC ACID. 0- 000088-99-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PHTHALIC ACID. P- 000100-21-0
NOEL 142 MG/KG/DAY RAT
ORAL: DIET 2 YEARS BLADDER
HYPERPLASIA
1E+0
100
1E+0
100
010046
010048
PHTHALIC ANHYDRIDE
LOAEL 1562 MG/KG/DAY
ORAL: DIET
000085-44-9
MOUSE
104 WEEKS LUNG
KIDNEY
HISTOPATHOLOGY
HISTOPATHOLOGY
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
LOAEL 0.1 MG/CU M HUMAN
INHALATION: 12 YEARS NOSE
INTERMITTENT LUNGS
RHINITIS
BRONCHITIS
1.2E-1
300
2E+0
1000
1.2E-1
300
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
IRIS
010049
010847
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-82
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL
LEVEL
ROUTE
SPECIES
EXPERIMENT LENGTH
POLYBROMINATED BIPHENYLS
LOAEL 0.07 MG/KG/DAY RAT
ORAL: GAVAGE 25 WEEKS
TARGET CRITICAL EFFECT
LIVER INCREASED WEIGHT
LIVER LESIONS
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (ma/cu m) (ma/kq/dav)
UF UF UF UF
7E-5
1000
7E-6
10000
010050
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
POTASSIUM CYANIDE
NOAEL 27 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000151-50-8

WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
5E-2
500
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
POTASSIUM SILVER CYANIDE
NOAEL 82.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000506-61-6

WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
2E-1
500
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
010278
010279
PROFLURALIN
NOEL 3 MG/KG/DAY
ORAL: DIET
026399-36-0
RAT
SUBCHRONIC
NONE OBSERVED
6E-3
500
6E-3
500
010051
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-83
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL EQSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
PRONAMIDE 023950-58-5
NOEL 7.5 MG/KG/DAY DOG
ORAL: DIET 2 YEARS
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (nn/ka/dav) (mq/cu m) (mq/kq/dav)
UF UF UF UF
NONE OBSERVED

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
PROPACHLOR
NOEL 13.3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS
001918-16-7
WHOLE BODY
DECREASED WEIGHT GAIN
PROPAZINE 000139-40-2
NOEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

PROPIONITRILE 000107-12-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

PROPYL ALCOHOL. N- 000071-23-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
7.5E-2
100
1.3E-1
100
2E-2
300
IRIS 010280
IRIS
010175
IRIS 010052
010053
005627
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-84
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
PROPYLENE GLYCOL
NOEL 50000 PPM
ORAL: DIET
NOEL 6 *
ORAL: DIET
000057-55-6
DOG
2 YEARS
RAT
20 WEEKS
KIDNEY
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kq/dav) (mg/cu m) (mq/kq/dayl
UF UF UF UF
ERYTHROCYTES DECREASED COUNT
BLOOD DECREASED HEMATOCRIT
BLOOD DECREASED HEMOGLOBIN
2E+1
100
LESIONS
3E+1
100
IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/25/91) BY THE RfD/RfC WORK GROUP.
005631

005629

010914
PROPYLENE GLYCOL MONOETHYL ETHER 001569-02-4
NOEL 680 MG/KG/DAY RAT
ORAL: DRINKING 30 DAYS WHOLE BODY
WATER
DECREASED WEIGHT GAIN
7E+0
100
7E-1
1000
IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/25/91) BY THE RfD/RfC WORK GROUP.
005488
010915
PROPYLENE GLYCOL MONOMETHYL ETHER
NOEL 947 MG/KG/DAY RAT
ORAL: GAVAGE 35 DAYS
NOAEL 1000 PPM
INHALATION:
INTERMITTENT
000107-98-2

LIVER
KIDNEY
HISTOPATHOLOGY
HISTOPATHOLOGY
RAT. RABBIT
13 WEEKS CENTRAL NERVOUS EFFECTS
SYSTEM
7E+0
100
7E-1
1000
2E+1
30
IRIS
005486
010276
IRK. EPA-S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-85
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL BEE. SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (ma/ka/dav) (ma/cu m) (mg/kg/dav)
UF UF UF UF
PROPYLENE OXIDE 000075-56-9
LOAEL 71 MG/CU M RAT
INHALATION: 2 YEARS EPITHELIUM UNSPECIFIED
INTERMITTENT
3E-2
100
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RFC].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
010375
PYRENE 000129-00-0
NOAEL 75 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WKS KIDNEY
EFFECTS
3E-1
300
IRIS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP
010176
010968
PYRIDINE
NOAEL 1 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000110-86-1

LIVER
LIVER
INCREASED WEIGHT
INCREASED RELATIVE WEIGHT
1E-2
100
IRIS
010055
RDX / (CYCLONITE)
NOEL 0.3 MG/KG/DAY
ORAL
000121-82-4
RAT
105 WEEKS PROSTATE
PROSTATE
INFLAMMATION
HEMOSIDEROSIS
3E-3
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS
010056
RONNEL 000299-84-3
NOAEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER
EFFECTS
5E-2
100
5E-2
100
010057
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-86
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (ma/ko/day) (ma/cu m) (ma/kg/dav)
UF UF UF UF
SELENIOUS ACID 007783-00-8
NOAEL 0.046 MG/KG/DAY HUMAN
ORAL: DIET WHOLE BODY SELENOSIS. CLINICAL

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
5E-3
3
IRIS 010504
SELENIUM
NOAEL 0.853 MG/DAY
ORAL: DIET
HUMAN
007782-49-2
WHOLE BODY
SELENOSIS. CLINICAL
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
5E-3
3
IRIS
010404
SELENOUREA
NOAEL 0.072 MG/KG/DAY
ORAL: DIET
000630-10-4
HUMAN
5E-3
15
WHOLE BODY SELENOSIS

CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (05/01/91). UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
5E-3
15
010473
SILVER
LOAEL 0.014 MG/KG/DAY
IV
007440-22-4
HUMAN
2-9 YEARS SKIN
ARGYRIA
5E-3
3
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A TOTAL IV DOSE OF 1 GRAM.
IRIS
010453
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-87
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) May 1995

Subchronic Chronic
CHEMICAL QQSI SPECIES [RfC] [RfD] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (ma/cu m) (mq/ka/dav) (mo/cu m) (ma/ka/dav)
UF UF UF UF

SILVER CYANIDE 000506-64-9
NOAEL 55.7 MG/KG/OAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 1E-1 IRIS 010283
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION

SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.

SIHAZINE 000122-34-9
NOAEL 0.52 MG/(KG-DAY) RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 5E-3 IRIS 010955
BLOOD HEMATOLOGICAL EFFECTS 100

SUBCHRONIC [RfD] COMMENT: THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY

SODIUM CYANIDE 000143-33-9
NOAEL 20.4 MG/KG/DAY RAT
ORAL: DIET CENTRAL NERVOUS EFFECTS 4E-2 IRIS 005640
SYSTEM 500

SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.

SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
NOEL 30 MG/KG/DAY RAT
ORAL 90 DAYS EYE CATARACTS 3E-1 IRIS 005644
WHOLE BODY DECREASED WEIGHT 100

GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254. 1-88
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
May 1995
CHEMICAL CQSI SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
SODIUM METAVANADATE 013718-26-8
NQAEL 10 PPM RAT
ORAL: DRINKING 3 MONTHS KIDNEY
WATER
CRITICAL EFFECT
IMPAIRED FUNCTION
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mg/kg/dav) (mg/cu m) (mg/kg/day)
UF UF UF UF
1E-2
100
1E-3
1000
005735
STRONTIUM. STABLE
NOAEL 190 MG/KG/DAY
ORAL: DRINKING
WATER
007440-24-6
RAT, YOUNG
20 DAYS BONE
RACHITIC CHANGES

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
6E-1
300
IRIS
010842
STRYCHNINE 000057-24-9
LOAEL 2.5 MG/KG/DAY RAT
ORAL: GAVAGE 28 DAYS UNSPECIFIED
UNSPECIFIED
GENERAL COMMENT: THE LOAEL IS ALSO THE FEL.
STYRENE
000100-42-5
NOAEL 22 PPM
INHALATION:
OCCUPATIONAL
HUMAN
TOXICITY
HISTOPATHOLOGY
CENTRAL EFFECTS
NERVOUS SYSTEM
3E+0
10
3E-3
1000
IRIS
IRIS
IRIS
CHRONIC [RfC] COMMENT: THE MEAN DURATION OF EXPOSURE FOR 50 WORKERS WAS 8.6 YEARS AIR EXPOSURE CONCENTRATIONS WERE
ESTIMATED FROM THE SUMMATION OF THE PRINCIPLE URINARY METABOLITES OF STYRENE MANDELIC ACID AND
PHENYLGLYOXYLIC ACID. SEE IRIS FOR MORE INFORMATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
010285
010059

010511
SUCCINONITRILE- 000110-61-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
005585
1-89
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD]
(rnq/cu m) (mQ/ka/dav) (ma/cu m) (ma/ka/dav)
UF UF UF UF
SULFUR DIOXIDE 007446-09-5
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
May 1995

REFERENCE

010505
SULFUR OXIDES
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
010035
SULFURIC ACID
NOAEL 0.066-0.098 MG/CU M HUMAN
INHALATION
007664-93-9

RESPIRATORY
SYSTEM
RESPIRATORY EFFECTS
CHRONIC [RfC] COMMENT: REPORTED EFFECTS OCCURRED AT PORTAL OF ENTRY. ESTIMATES OF MG/DAY REFERENCE DOSES ARE
INAPPROPRIATE BECAUSE EFFECTS AT PORTAL OF ENTRY DEPEND ON CONCENTRATION IN AIR. AN ACCEPTABLE
AIR CONCENTRATION OF 0.07 MG/CU M WAS ESTIMATED BY CARSON ET AL (1981) FROM AVAILABLE DATA.
005647
TEMEPHOS 003383-96-8
NOAEL 200 PPM RAT
ORAL: DIET 99 DAYS
2E-1
100
2E-2 010060
1000
TERBUFOS
NOAEL 0.0025 MG/KG/DAY
ORAL: DIET
013071-79-9
DOG
6 MONTHS
CHOLINESTERASE INHIBITION
2.5E-5
100
2.5E-5 010408
100
TEREPHTHALIC ACID 000100-21-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
010474
TETRACHLOROAZOXYBENZENE 021232-47-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010064
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-90
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
May 1995
CHEMICAL CQ$t SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
TETRACHLORQBENZENE. 1.2.4.5- 000095-94-3
NOAEL 0.34 MG/KG/QAY RAT
ORAL: DIET 13 WEEKS KIDNEY
CRITICAL EFFECT
LESIONS
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (ma/kQ/dav) (irc/cu m) (mg/kg/dav)
UF UF UF UF
3E-3
100
IRIS
010286
TETRACHLOROCYCLOPENTADIENE 000695-77-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005303
TETRACHLOROETHANE. 1.1.1.2- 000630-20-6
LOAEL 89.3 MG/KG/DAY RAT
ORAL: GAVAGE 103 WEEKS LIVER
KIDNEY
LESIONS
LESIONS
3E-2
3000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TETRACHLOROETHYLENE 000127-18-4
NOAEL 14 MG/KG/DAY MOUSE
ORAL 6 WEEKS LIVER
HEPATOTOXICITY
1E-1
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS
010407
IRIS
005650
TETRACHLOROHYDRAZOBENZENE 071753-42-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010065
TETRACHLOROPHENOL. 2.3.4.5- 004901-51-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005324
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-91
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE- EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (ma/ka/dav) (ma/cu m) (ma/ka/dav)
UF UF UF UF
TETRACHLOROPHENOL. 2.3.4.6- 000058-90-2
NOAEL 25 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER
LIVER
INCREASED WEIGHT
CENTRILOBULAR HYPERTROPHY
3E-1
100
IRIS
005323
TETRACHLOROPHENOL. 2.3.5.6- 000935-95-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005325
TETRACHLOROPROPENE. 1.1.2.3- 010436-39-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010066
TETRACHLOROVINPHOS / (STIROPHOS)
NOEL 3.1 MG/KG/DAY DOG
ORAL: DIET 2 YEARS
000961-11-5
LIVER
KIDNEY
WHOLE BODY
INCREASED WEIGHT
INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
3E-2
100
IRIS 010067
TETRAETHYL DITHIOPYROPHOSPHATE 003689-24-5
NOEL 0.5 MG/KG/DAY RAT
ORAL: DIET 3 MONTHS ERYTHROCYTES

BLOOD
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
5E-3
100
IRIS 010287
THALLIC OXIDE 001314-32-5
CHRONIC [RfD] COMMENT- THE CHRONIC ORAL [RfD]' IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
010956
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION- RISK INFORMATION HOTLINE: (513) 569-7254.
1-92
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfD]
(mg/cu m) (mg/kg/dav)
UF UF
Chronic
[RfC] [RfD]
(mg/cu m) (mg/kg/dav)
UF UF
REFERENCE
THALLIUM (I) ACETATE
NOAEL 0.26 MG/KG/DAY RAT
ORAL 90 DAYS
000563-68-8

LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
9E-4
300
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM CD SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I) CARBONATE
NOAEL 0.23 MG/KG/DAY RAT
ORAL 90 DAYS
006533-73-9

LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
8E-4
300
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I) CHLORIDE
NOAEL 0.23 MG/KG/DAY RAT
ORAL 90 DAYS
007791-12-0

LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
BE-4
300
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
005664
005668
005672
THALLIUM. INSOLUBLE SALTS
CHRONIC [RfD] COMMENT: REFER TO IRIS FOR OTHER THALLIUM SALTS.
010458
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-93
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (mg/cu m) (mq/kq/dav)
UF UF UF UF
THALLIUM (I) NITRATE
NOAEL 0.26 MG/KG/DAY RAT
ORAL 90 DAYS
010102-45-1

LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
9E-4
300
IRIS
005676
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM SELENITE
012039-52-0
010957
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS WITHDRAWN FROM IRIS (08/01/93) THE CHRONIC ORAL [RfD] IS
CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
THALLIUM (I) SULFATE
NOAEL 0.25 MG/KG/DAY RAT
ORAL 90 DAYS
007446-18-6

LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
8E-4
300
IRIS
005682
THIOCYANOMETHYLTHIO)BENZOTHIAZOLE, 2-(
NOEL 25 MG/KG/DAY RAT
ORAL: DIET SUBCHRONIC STOMACH
021564-17-0

LESIONS
3E-1
100
3E-2
1000
010068
SUBCHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
CHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-94
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
LEVEL
BQSI SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
THIOFANOX
NOAEL 0.025 MG/KG/DAY DOG
ORAL 8 DAYS
013196-18-4
CHOLINESTERASE DECREASED CHOLINESTERASE
ACTIVITY
SUBCHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
CHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mq/cu m) (mQ/ka/dav) (mo/cu m) (mq/kq/dav)
UF UF UF UF
May 1995

REFERENCE
3E-4
100
3E-4
100
010069
THIRAM
NOAEL 0.61 MG/KG/DAY
ORAL
000137-26-8
FERRET
24 WEEKS
REPRODUCTION
IMPAIRED
6E-3
100
IRIS
010459

010070
TIN AND COMPOUNDS
NOAEL 2000 PPM RAT
ORAL: DIET 2 YEARS
LIVER
KIDNEY
LESIONS
LESIONS
6E-1
100
6E-1
100
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
005688
TOLUENE
NOAEL 223 MG/KG/DAY
ORAL: GAVAGE
000108-88-3
RAT
13 WEEKS
LIVER
KIDNEY
ALTERED WEIGHT
ALTERED WEIGHT
2E+0
100
IRIS
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
IRIS
010469
010844
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-95
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mQ/kq/dav) (ma/cu m) (mg/kg/dav)
UF UF UF UF
TOLUENE-2.5-DIAMINE
NOAEL 56 MG/KG/DAY
ORAL: DIET
000095-70-5
RAT
78 WEEKS
SUBCHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT
CHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
TOLUENE-2.6-DIAMINE 000823-40-5
NOAEL 16 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
SUBCHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE.
CHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE
6E-1
100
2E-1
100
6E-1 010073
100
2E-1
100
010074
TOLUENEDIAMINE. 2.3- 002687-25-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010071
TOLUENEDIAMINE. 3.4- 000496-72-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010072
TOLUIDINE. M- 000108-44-1
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010075
TRIALLATE
NOAEL 1.275 MG/KG/DAY
ORAL: DIET
002303-17-5
DOG
24 MONTHS SPLEEN
LIVER
EFFECTS
EFFECTS
1.3E-2
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
IRIS
010076
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-96
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
£tftll£AL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
TRIBROMOBENZENE. 1.2,4-
NOAEL 5 MG/KG/DAY
ORAL: DIET
000615-54-3
RAT
45 OR 90
DAYS
LIVER
LIVER
CRITICAL EFFECT
ALTERED WEIGHT
ENZYME INDUCTION
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ma/cu m) (ma/kg/dav) (mg/cu m) (mg/kg/dav)
UF UF UF UF
5E-2
100
TRICHLORO-1.2.2-TRIFLUOROETHANE. 1.1.2- 000076-13-1

WHOLE BODY DECREASED WEIGHT

SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.2.
NOEL 2000 PPM
INHALATION:
INTERMITTENT
RAT
24 MONTHS
3E+1
100
3E+0
100
TRICHLORO-2--HYDROXYDIPHENYLETHER. 2.2.41- 003380-34-5
NOEL 500 MG/KG/DAY RAT
ORAL 4 WEEKS WHOLE BODY DECREASED WEIGHT
TRICHLOROBENZENE. 1.2.4- 000120-82-1
NOAEL 100 PPM RAT
ORAL: DRINKING ADRENAL
WATER
INCREASED WEIGHT
4E+0
100
1E-2
1000
SUBCHRONIC [RfD] COMMENT: BASED ON A MULTIGENERATION REPRODUCTION STUDY.

NOAEL 104 PPM

INHALATION
RAT. RABBIT.
DOG. MONKEY
6 AND 26 LIVER
WEEKS
NON-ADVERSE WEIGHT CHANGES
2E+0
100
TRICHLOROCYCLOPENTADIENE 077323-84-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
3E+1
100
2E-1
1000
IRIS
IRIS
IRIS
010077

010460

010376
005492
010506
010958
005304
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-97
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kg/dav) (rog/cu m) (mg/kg/dav)
UF UF UF UF
TRICHLOROETHANE. 1.1.1- 000071-55-6
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
TRICHLOROETHANE. 1.1.2-
NOAEL 3.9 MG/KG/DAY
ORAL: DRINKING
WATER
000079-00-5
MOUSE
90 DAYS
BLOOD
CLINICAL CHEMISTRY ALTERATIONS
4E-2
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS
005702
TRICHLOROFLUOROHETHANE
LOAEL 1000 MG/KG/DAY
ORAL
000075-69-4
RAT
6 WEEKS
WHOLE BODY
INCREASED MORTALITY
7E-1
1000
IRIS
005502
005500
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
TRICHLOROPHENOL. 2.3.4- 015950-66-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005330
TRICHLOROPHENOL. 2.3.5- 000933-78-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005331
TRICHLOROPHENOL. 2.3.6- 000933-75-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005332
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-98
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
LEVEL
QQ5I SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
TRICHLOROPHENOL. 2.4.5-
NOEL 1000 PPM RAT
ORAL: DIET 98 DAYS
000095-95-4

LIVER
KIDNEY
CRITICAL EFFECT
HEPATOTOXICITY
EFFECTS
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mo/kQ/dav) (mq/cu tn) (mQ/ka/dav)
UF UF UF UF
1E+0
100
IRIS
IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/24/91) BY THE RfD/RfC WORK GROUP.
005329
010919
TRICHLOROPHENOL. 2.4.6-
000088-06-2
IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/24/91) BY THE RfD/RfC WORK GROUP
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
010461
TRICHLOROPHENOL. 3.4.5- 000609-19-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005333
TRICHLOROPHENOXY) PROPIONIC ACID. 2(2.4.5- 000093-72-1
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER HISTOPATHOLOGY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
8E-3
100
IRIS 010284
TRICHLOROPHENOXYACETIC ACID. 2.4.5- 000093-76-5
NOEL 10 MG/KG/DAY RAT
ORAL: DIET 90 DAYS
KIDNEY
LIVER
WEIGHT EFFECTS
WEIGHT EFFECTS
1E-1
100
TRICHLOROPROPANE. 1.1.1- 007789-89-1
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
IRIS 010178

010179

005705
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-99
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
CHEMICAL
LEVEL
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (ma/ka/dav) (mo/cu m) (ma/ka/dav)
UF UF UF UF
May 1995

REFERENCE
TRICHLOROPROPANE. 1.1.2- 000598-77-6
NOEL 100 MG/L RAT
ORAL: DRINKING 13 WEEKS LIVER HISTOPATHOLOGY
WATER KIDNEY HISTOPATHOLOGY
THYROID HISTOPATHOLOGY
5E-2
300
IRIS
005708
TRICHLOROPROPANE. 1.2.2- 003175-23-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005706
TRICHLOROPROPANE. 1.2.3- 000096-18-4
NOAEL 8 MG/KG/DAY RAT
ORAL 120 DAYS
WHOLE BODY
LIVER
KIDNEY
ERYTHROCYTES
BLOOD
BLOOD
TOXICITY
LESIONS
LESIONS
DECREASED COUNT
DECREASED HEMATOCRIT
DECREASED HEMOGLOBIN
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TRICHLOROPROPENE. 1.2.3- 000096-19-5
NOEL 18 MG/CU M DOG
INHALATION: 66 WEEKS EYE
INTERMITTENT
IRRITATION
6E-2
100
IRIS 005714
5E-3
100
5E-3 010078
100
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-100
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
TRICHLOROTOLUENE. 2.3.6- 002077-46-5
LOAEL 0.5 PPM RAT
ORAL: DIET 28 DAYS LIVER
KIDNEY
THYROID
CRITICAL EFFECT
LESIONS
LESIONS
LESIONS
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/ka/dav) (mq/cu m) (mq/ka/dav)
UF UF UF UF
5E-5
1000
005335
TRICHLOROTOLUENE. ALPHA.2.6-
LOAEL 0.5 PPM RAT
ORAL: DIET 28 DAYS
002014-83-7

LIVER
KIDNEY
THYROID
LESIONS
LESIONS
LESIONS
5E-5
1000
005339
TRIFLURALIN
NOEL 0.75 MG/KG/DAY
ORAL: DIET
001582-09-8
DOG
12 MONTHS LIVER
BLOOD
INCREASED WEIGHT
METHEMOGLOBINEMIA
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
7.5E-3
100
IRIS 010080
TRIMETHYLBENZENES
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005727
TRINITROBENZENE. 1.3.5-
NOAEL 0.51 MG/KG/DAY
ORAL: WATER
000099-35-4
RAT
16 WEEKS
SPLEEN
INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: CALCULATED FROM DATA OBTAINED WITH 1.3-DINITROBENZENE
CHRONIC [RfD] COMMENT: CALCULATED FROM DATA OBTAINED WITH 1.3-DINITROBENZENE
5E-4
1000
IRIS 010081
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-101
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL CQSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mQ/ko/dav) (mo/cu m) (ma/kg/dayl
UF UF UF UF
TRINITROPHENOLS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010082
TRINITROPHENYLMETHYLNITRAMINE 000479-45-8
LOAEL 125 MG/KG/DAY RABBIT
ORAL: GAVAGE 9 MONTHS LIVER
KIDNEY
SPLEEN
HISTOPATHOLOGICAL EFFECTS
HISTOPATHOLOGICAL EFFECTS
HISTOPATHOLOGICAL EFFECTS
1E-1
1000
1E-2 010377
10000
TRINITROTOLUENE. 2.4.6-
LOAEL 0.5 MG/KG/DAY
ORAL: GAVAGE
DOG
000118-96-7
LIVER
EFFECTS
5E-4
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

URANIUM. SOLUBLE SALTS
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
IRIS
010416
VANADIUM
NOAEL 5 PPM
ORAL: DRINKING
WATER
007440-62-2
RAT
LIFETIME
7E-3
100
7E-3 005739
100
VANADIUM PENTOXIDE
NOAEL 17.85 PPM
ORAL: DIET
001314-62-1
RAT
LIFETIME
9E-3
100
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]

IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
005743
1-102
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
VANADIUM SULFATE 036907-42-3
NOAEL 2.24 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME
WATER
VERNAH / (VERNOLATE)
NOEL 1 MG/KG/DAY RAT
ORAL: DIET
VINYL ACETATE
NOAEL 100 MG/KG/DAY RAT
ORAL: WATER 2 YEARS
001929-77-7

WHOLE BODY

000108-05-4

WHOLE BODY
KIDNEY
NOAEL 176 MG/CU M MOUSE
INHALATION: 104 WEEKS
INTERMITTENT
CRITICAL EFFECT
DECREASED WEIGHT
ALTERED WEIGHT
ALTERED WEIGHT
NASAL CAVITY LESIONS
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (ina/kq/dav) (im/cu m) (ma/ka/dav)
005747
UF

2E-1
30
UF
2E-2
100
1E-2
100
1E+0
100

UF UF
2E-2
100
IRIS
1E+0
100
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].

VINYL CHLORIDE 000075-01-4
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300.
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
010083
010417
010418
VINYL-1-CYCLOHEXENE. 4- 000100-40-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010084
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-103
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
WARFARIN
LOAEL 2 MG/DAY
ORAL
000081-81-2
HUMAN
CRITICAL EFFECT
INCREASED PROTHROMBIN TIME
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (ma/ka/dav) (mg/cu m) (mQ/ka/dav)
UF UF UF UF
BLOOD

SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
3E-4
100
IRIS 010409
XYLENE. M-
NOAEL 250 MG/KG
ORAL: GAVAGE
000108-38-3
RAT
103 WEEKS CENTRAL NERVOUS HYPERACTIVITY
SYSTEM
WHOLE BODY DECREASED WEIGHT
WHOLE BODY
2E+0
100
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.

CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
005755
010920
IRIS
XYLENE. MIXTURE 001330-20-7

SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300

CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
010872

010921
XYLENE. 0-
NOEL 250 MG/KG
ORAL: GAVAGE
000095-47-6
RAT
103 WEEKS CENTRAL NERVOUS HYPERACTIVITY
SYSTEM
WHOLE BODY DECREASED WEIGHT
2E+0
100
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.

CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
005751
010922
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-104
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

Subchronic
May 1995
CHEMICAL CQSI SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mq/cu m) (mq/kq/dav) (mq/cu m) (mq/kq/dav)
UF UF UF UF
XYLENE. P- 000106-42-3
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.

CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
010923
ZINC (METALLIC)
LOAEL 1.0 MG/KG/DAY
ORAL: DIET
SUPPLEMENT
007440-66-6
HUMAN
10 WEEKS
BLOOD DECREASED BLOOD ENZYME

CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
3E-1
3
IRIS
010937
ZINC CYANIDE
NOAEL 24.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000557-21-1

WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
5E-2
500
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
010289
ZINC PHOSPHIDE
LOAEL 3.48 MG/KG/DAY
ORAL: DIET
001314-84-7
RAT
13 WEEKS
WHOLE BODY
WHOLE BODY
DECREASED WEIGHT
DECREASED FOOD INTAKE
3E-3
1000
IRIS
010290
ZINEB 012122-67-7
LOAEL 25 MG/KG/DAY RAT
ORAL: DIET 2 YEARS THYROID
HYPERPLASIA
5E-2
500
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS
010085
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254
1-105
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ACENAPHTHENE 000083-32-9
010165 US EPA. 1989. MOUSE ORAL SUBCHRONIC STUDY WITH ACENAPHTHENE. STUDY CONDUCTED BY HAZELTON LABORATORIES. INC.. FOR THE OFFICE OF SOLID
WASTE. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

ACENAPHTHYLENE 000208-96-8
005202 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACENAPHTHYLENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

ACEPHATE 030560-19-1
005833 CHEVRON CHEMICAL COMPANY. 1987. CONFIDENTIAL BUSINESS INFORMATION UNPUBLISHED DATA. MRID NO. 40504819

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACEPHATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

ACETONE 000067-64-1
005204 US EPA. 1986. NINETY-DAY GAVAGE STUDY IN ALBINO RATS USING ACETONE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR ACETONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

ACETONE CYANOHYDRIN / (METHYLLACTONITRILE) 000075-86-5
005776 HAZELTON LABORATORIES AMERICA. 1988. SUBCHRONIC TOXICITY STUDY IN RATS WITH 2-METHYLLACTONITRILE. HLA STUDY NO. 2399-114. REPORT PREPARED
FOR DYNAMAC CORPORATION.

US EPA. 1994. RfD/RfC WORK GROUP.

ACETONITRILE 000075-05-8
005210 NATIONAL TOXICOLOGY PROGRAM (NTP). 1983. 90-DAY SUBCHRONIC TOXICITY STUDIES OF ACETONITRILE IN RATS AND MICE. REPORT TO NATIONAL
TOXICOLOGY PROGRAM.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACETONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ACETOPHENONE 000098-86-2
005212 HAGAN. EC. WH HANSEN. OG FITZHUGH. ET AL 1967. FOOD FLAVORINGS AND COMPOUNDS OF RELATED STRUCTURE. II. SUBACUTE AND CHRONIC TOXICITY.
FOOD COSMET. TOXICOL. 5(2): 141-157

US EPA. 1987. RfD/RfC WORK GROUP

010874 US EPA. 1992. RfD/RfC WORK GROUP.

ACROLEIN 000107-02-8
010390 NEWELL GW. 1958. ACUTE AND SUBACUTE TOXICITY OF ACROLEIN. STANFORD RESEARCH INSTITUTE. SRI PROJECT NO. 5-868-2.

NAS (NATIONAL ACADEMY OF SCIENCES). 1977. DRINKING WATER AND HUMAN HEALTH. WASHINGTON. DC.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACROLEIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

010856 FERON VJ. A KRUYSSE. HP TIL. AND HR IMMEL 1978 REPEATED EXPOSURE TO ACROLEIN VAPOR: SUBACUTE STUDIES IN HAMSTERS. RATS AND RABBITS.
TOXICOLOGY. 9: 47-57.

US EPA. 1991. RfD/RfC WORK GROUP.

ACRYLAMIDE 000079-06-1
005835 BUREK JD. RR ALBEE. JE BEYER. ET AL. 1980. SUBCHRONIC TOXICITY OF ACRYLAMIDE ADMINISTERED TO RATS IN THE DRINKING WATER FOLLOWED BY UP TO
144 DAYS OF RECOVERY. J ENVIRON PATHOL TOXICOL. 4: 157-182.

US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACRYLAMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. RFD/RFC WORK GROUP.

010876 US EPA. 1990. RfD/RfC WORK GROUP
R^2
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ACRYLIC ACID 000079-10-7
005836 BASF. 1993. REPRODUCTION TOXICITY STUDY WITH ACRYLIC ACID IN RATS: CONTINUOUS ADMINISTRATION IN THE DRINKING WATER OVER 2 GENERATIONS
(1 LITTER IN THE FIRST AND 1 LITTER IN THE SECOND GENERATION). PROJECT NO 71R0114/92011. BASF AKTIENGELLSCHAFT. DEPT. OF TOXICOLOGY.
RHEIN. FRG.

US EPA. 1994. RfD/RfC WORK GROUP.

010346 MILLER. RR. JA AYERS. GC JERSEY AND MJ MCKENNA. 1981. INHALATION TOXICITY OF ACRYLIC ACID. FUND APPL TOXICOL. 1(3): 271-277.

MILLER. RR. JA AYERS. GC JERSEY 1979. ACRYLIC ACID 90-DAY VAPOR INHALATION STUDY WITH RATS AND MICE. FINAL REPORT I79RC-1024. TOXICOLOGY
RESEARCH LABORATORY. HEALTH AND ENVIRONMENTAL SCIENCE. DOW CHEMICAL COMPANY. MIDLAND, MI.

US EPA. 1990. RfD/RfC WORK GROUP.

ACRYLONITRILE 000107-13-1
010939 TANDON R. DK SAXENA. SV CHANDRA. PK SETH. SP SRIVASTAVA. 1988. TESTICULAR EFFECTS OF ACRYLONITRILE IN MICE. TOXICOLOGY LETTERS. 42:
55-63.

BIODYNAMICS. 1980. A TWENTY-FOUR MONTH ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED TO SPARTAN RATS IN THE DRINKING
WATER. VOL 1-2. PREPARED BY BIODYNAMICS. INC . DIVISION OF BIOLOGY AND SAFETY EVALUATION. EAST MILLSTONE. NJ. FOR MONSANTO COMPANY. ST.
LOUIS. MO.

US EPA. 1993. RfD/RfC WORK GROUP.
ADIPONITRILE 000111-69-3
005157 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ADIPONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ALACHLOR 015972-60-8
005837 MONSANTO CO. 1984. MRID NO 00148923. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC. 20460.

US EPA. 1992. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ALACHLOR. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE OF THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALACHLOR. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1991. RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Nay 1995

ALDICARB 000116-06-3
010960 RHONE-POULENC AG COMPANY. 1992. MRID NO 423730-01. HED DOC NO 010459. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

UNION CARBIDE CORP. 1971. R RAINES. JB DERNEHL. JB BLOCK. SUPERVISING PHYSICIANS. INGESTION OF ALDICARB BY HUMAN VOLUNTEERS' A CONTROLLED
STUDY OF THE EFFECTS OF ALDICARB ON MAN. ALO-03-77-2215. FEB 11. 1971. MRID NO 00101911. HED DOC NO 010450. AVAILABLE FROM EPA. WRITE TO
FOI. EPA. WASHINGTON. DC 20460.

GOLDMAN LR. M SELLER. RJ JACKSON. 1990. ALDICARB FOOD POISONING IN CALIFORNIA. 1985-1988: TOXICITY ESTIMATES FOR HUMANS. ARCH ENVIRON
HEALTH. 45(3): 141-147. HED DOC NO 010451. 010455. 010458. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

GOLDMAN. LR. DF SMITH. RR NEUTRA ET AL. 1990. PESTICIDE FOOD POISONING FROM CONTAMINATED WATERMELONS IN CALIFORNIA. 1985 ARCH ENVIRON
HEALTH. 45(4): 229-236.

HIRSCH GH. BT MORI. GB MORGAN. PR BENNET. BC WILLIAMS. 1987. REPORT OF ILLNESSES CAUSED BY ALDICARB-CONTAMINATED CUCUMBERS. FOOD
ADDITIVES AND CONTAMINANTS. 5(2): 155-60. HED DOC NO 010455. 010458. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 020460.

US EPA. 1992. RfO/RfC WORK GROUP.

ALDRIN 000309-00-2
005159 FITZHUGH OG. AA NELSON AND ML QUAIFE. 1964. CHRONIC ORAL TOXICITY OF ALDRIN AND DIELDRIN IN RATS AND DOGS FOOD COSMET TOXICOL 2'
551-562.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ALDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

ALLIDOCHLOR 000093-71-0
005838 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLIDOCHLOR. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ALLYL ALCOHOL 000107-18-6
005839 CARPANINI FMB. IF GAUNT, J HARDY. ET AL 1978. SHORT-TERM TOXICITY OF ALLYL ALCOHOL IN RATS. TOXICOLOGY. 9: 29-45.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL ALCOHOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ALLYL CHLORIDE 000107-05-1
010369 BOQUIN. L. D SHUWEI. Y AIRU. ET AL 1982. STUDIES ON THE TOXICITY OF ALLYL CHLORIDE. ECOTOXICOL ENVIRON SAP. 6: 19-27.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ALUMINUM 007429-90-5
005162 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ALUMINUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

ALUMINUM PHOSPHIDE 020859-73-8
010255 HACKENBURG U. 1972. CHRONIC INGESTION BY RATS OF STANDARD DIET TREATED WITH ALUMINUM PHOSPHIDE. TOXICOL APPL PHARMACOL. 23(1): 147-158.

US EPA. 1985. RfD/RfC WORK GROUP.

AMETRYN 000834-12-8
005841 CIBA-GEIGY CORPORATION. 1961. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO. 00034843. AVAILABLE FROM EPA. WRITE TO FOI.
EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMETRYN. PREPARED BY THE OFFICE of HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP

AMINO-2-NAPHTHOL. 1- 002834-92-6
005842 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR l-AMINO-2-NAPHTOL AND l-AMINO-2-NAPHTOL HYDROCHLORIDE. PREPARED BY THE OFFICE
OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON, DC.

AMINO-2-NAPHTOL HYDROCHLORIDE. 1- 001198-27-2
005843 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR l-AMINO-2-NAPHTOL AND l-AMINO-2-NAPHTOL HYDROCHLORIDE. PREPARED BY THE OFFICE •
OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE.
WASHINGTON. DC.

AMINOPHENOL. M- 000591-27-5
005844 RE TA. RF LOEHR. SC RODRIGUEZ. ET AL 1984 RESULTS OF TERATOGENICITY TESTING OF M-AMINOPHENOL IN SPRAGUE-DAWLEY RATS. FUND APPL TOXICOL.
4(1) 98-104.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY

(OTHER THAN CARCINOGENICITY) May 1995

AMINOPHENOL. 0- 000095-55-6
005845 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

AMINOPHENOL. P- . 000123-30-8
005846 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

AMINOPYRIDINE. 4- 000504-24-5
005847 KOHN FE. 1968. FOUR-WEEK SUBACUTE ORAL TOXICITY OF COMPOUND 1861 HYDROCHLORIDE --ALBINO RATS. (UNPUBLISHED STUDY) PREPARED BY INDUSTRIAL
BIOTEST LABORATORIES. INC. UNDER 224-12 SUBMITTED BY PHILLIPS PETROLEUM CO.. BARTLESVILLE. OK. CDL: 229844-E.

US EPA. 1980. 4-AMINOPYRIDINE. AVITROL PESTICIDE REGISTRATION STANDARD. PREPARED BY THE OFFICE OF PESTICIDE PROGRAMS US EPA WASHINGTON
DC. NTIS PB84-209907.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4-AMINOPYRIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

AMMONIA 007664-41-7
005166 CAMPBELL CL. RK DAWES. S DEOLALKAR AND MC MERRITT. 1958. EFFECT OF CERTAIN CHEMICALS IN WATER ON THE FLAVOR OF BREWED COFFEE FOOD RES
23: 575-579. CITED IN US EPA. 1981. ' """""•

WHO (WORLD HEALTH ORGANIZATION). 1986. ENVIRONMENTAL HEALTH CRITERIA. 54. AMMONIA. WHO. GENEVA. SWITZERLAND.

US EPA. 1981. AMBIENT WATER QUALITY CRITERION FOR THE PROTECTION OF HUMAN HEALTH: AMMONIA. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS.
WASHINGTON. DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR AMMONIA. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

010392 HOLNESS DL. JT PURDHAM AND JR NETHERCOTT. 1989. ACUTE AND CHRONIC RESPIRATORY EFFECTS OF OCCUPATIONAL EXPOSURE TO AMMONIA AMIND HYG
ASSOC J. 50: 646-650.

BRODERSON JR. JR LINDSEY AND JE CRAWFORD. 1976. THE ROLE OF ENVIRONMENTAL AMMONIA IN RESPIRATORY MYCOPLASMOSIS OF RATS. AM J PATHOL. 85:
J.lb~ UU .

US EPA. 1991. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ANILINE 000062-53-3
010370 OBERST FW. E HACKLEY. C COMSTOCK 1956. CHRONIC TOXICITY OF ANILINE VAPOR (5PPM) BY INHALATION. ARCH INO HEALTH 13:379-384.

US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.

ANTHRACENE 000120-12-7
010166 US EPA. 1989. SUBCHRONIC TOXICITY IN MICE WITH ANTHRACENE. FINAL REPORT. HAZELTON LABORATORIES AMERICA. INC. PREPARED FOR THE OFFICE OF
SOLID WASTE. WASHINGTON. DC.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR ANTHRACENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

010964 US EPA. 1994. RfD/RfC WORK GROUP.

ANTIMONY PENTOXIDE 001314-60-9
005174 SCHROEOER HA. M KITCHENER AND AP NASON. 1970. ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR. 100: 59-66.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

ANTIMONY POTASSIUM TARTRATE 000304-61-0
005234 SCHROEDER HA. M MITCHENER AND AP NASON. 1970. ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR. 100: 59-69.

ANTIMONY TETROXIDE 001332-81-6
005238 SCHROEDER HA. M MITCHENER AND AP NASON. 1970. ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR. 100: 59-69.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMFNT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY M
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND

ENVIRONMENTAL CRITERIA AMD «SESSHEMT OFFICE. CINCINNATI. OH FOR THE CFFlS OF SollD I^ASTE
. IX,.
ANTIMONY TRIOXIDE 001309-64-4
005242 SCHROEDER HA. M MITCHENER AND AP NASON. 1970. ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR. 100: 59-69.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY '
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTS
: rRONMENTAL CRITERIA m ASSESSMENT OFFICE- CINCINNATI- w FOR ™E
ANTIMONY. METALLIC 007440-36-0

005170 SCHROEDER HA. M MITCHENER AND AP NASON. 1970 ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR. 100: 59-66.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY LND REM^IAlTsPmSE^fNGTS ™'
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTS

; ™m£mi CRITERIA m ASSESSMENT OFFICE' CINCINNAT<- * FOR THE OFFICE
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ARAMITE 000140-57-8
005849 OSER BL. M OSER 1962. 2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE) II. CARCINOGENICITY. TOXICOL APPL PHARMACOL. 4:
70-88.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ARAMITE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

005850 POPPER H. SS STERNBERG. BL OSER AND M OSER. 1960. THE CARCINOGENIC EFFECT OF ARAMITE IN RATS. CANCER. 13(5): 1035-1046.

OSER BL AND M OSER. 1962. 2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE). CARCINOGENICITY. TOXICOL APPL PHARMACOL. 4:
70-88.

AROCLOR 1248 012672-29-6
010940 US EPA. 1993. RfD/RfC WORK GROUP.

AROCLOR 1254 011097-69-1
010963 US EPA. 1994 RfD/RfC WORK GROUP.

ARSENIC, INORGANIC 007440-38-2
010434 TSENG WP. 1977. EFFECTS AND DOSE-RESPONSE RELATIONSHIPS OF SKIN CANCER AND BLACKFOOT DISEASE WITH ARSENIC. ENVIRON. HEALTH PERSPECT. 19:
109-119.

TSENG. WP. HM CHU. SW HOU. JM FONG. CS LIN. S YEH. 1968. PREVALENCE OF SKIN CANCER IN AN ENDEMIC AREA OF CHRONIC ARSENICISM IN TAIWAN. J.
NATL. CANCER INST. 40: 453-463.

US EPA. 1990. RfD/RfC WORK GROUP.

ATRAZINE 001912-24-9
010855 CIBA-GEIGY CORP. 1986. MRID NO 00141874. 00157875. 00158930. 40629302. HED DOC NO 005940. 006937. AVAILABLE FROM EPA. WRITE TO FOI. EPA.
WASHINGTON. DC 20460.

CIBA-GEIGY CORP. AGRICULTURAL DIVISION. 1987. MRID NO 40431301. 41293801.HED DOC NO 006718. 006937. 007647. AVAILABLE FROM EPA. WRITE TO
FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1992. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

BARIUM 007440-39-3
010348 WONES. RG. BL STADLER. LA FROHMAN 1990 LACK OF EFFECT OF DRINKING WATER BARIUM ON CARDIOVASCULAR RISK FACTOR. ENVIRON HEALTH PERSPECT.
85: 1-13.

BRENNIMAN. GR. PS LEVY 1984. HIGH BARIUM LEVELS IN PUBLIC DRINKING WATER AND ITS ASSOCIATION WITH ELEVATED BLOOD PRESSURE. IN: ADVANCES
IN MODERN TOXICOLOGY IX. EJ CLALBRESE. ED PRINCETON SCIENTIFIC PUBLICATIONS. PRINCETON. NJ. P231-249

US EPA. 1985 DRINKING WATER CRITERIA DOCUMENT FOR BARIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC. EXT REVIEW DRAFT. FINAL DRAFT (ON PUBLIC
COMMENT). NTIS PB 86-118031/AS

US EPA. 1990 RfD/RfC WORK GROUP

BARIUM CYANIDE 000542-62-1
010941 US EPA. 1993. RfD/RfC WORK GROUP

BENEFIN 001861-40-1
005852 ELI LILLY AND CO 1972 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY MRID NO. 00037678. AVAILABLE FROM EPA. WRITE TO FOI. EPA.
WASHINGTON. DC 20460

US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENEFIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

BENZAL CHLORIDE 000098-87-3
005853 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZAL CHLORIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

BENZALDEHYDE 000100-52-7
005854 KLUWE WM. CA MONTGOMERY. HD GILES AND JD PREJEAU 1983. ENCEPHALOPATHY IN RATS AND NEPHROPATHY IN RATS AND MICE AFTER SUBCHRONIC ORAL
EXPOSURE TO BENZALDEHYDE. FOOD CHEM TOXICOL 21(3): 245-250.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

BENZALDEHYDE CYANOHYDRIN 000532-28-5
005781 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

BENZO[A]ANTHRACENE 000056-55-3
010965 US EPA. 1994. RfD/RfC WORK GROUP.

BENZENE 000071-43-2
010857 US EPA 1989. RfD/RfC WORK GROUP.

BENZENETHIOL / (THIOPHENOL) 000108-98-5
010942 AMERICAN BIOGENICS CORP. 1989. NINETY-DAY GAVAGE STUDY IN ALBINO RATS USING THIOPHENOL. PREPARED BY DYNAMAC CORP OF ROCKVILLE. MD FOR THE
US EPA OFFICE OF SOLID WASTE.

FAIRCHILD EJ AND HE STOKINGER 1958 TOXICOLOGIC STUDIES ON ORGANIC SULFUR COMPOUNDS. 1. ACUTE TOXICITY OF SOME ALIPHATIC AND AROMATIC
THIOLS (MERCAPTANS). AM IND HYG ASSOC J 19: 171-189.

US EPA. 1993. RfD/RfC WORK GROUP.

BENZIDINE 000092-87-5
005830 LITTLEFIELD NA. CJ NELSON AND CH FRITH. 1983 BENZIDINE DIHYDROCHLORIDE- TOXICOLOGICAL ASSESSMENTS IN MICE DURING CHRONIC EXPOSURE. J.
TOXICOL. ENVIRON. HEALTH. 12: 671-685.

US EPA. 1987. RfD/RfC WORK GROUP.

010877 US EPA. 1991. RfD/RfC WORK GROUP.

BENZOIC ACID 000065-85-0
005260 FDA (FOOD AND DRUG ADMINISTRATION). 1973. EVALUATION OF THE HEALTH ASPECTS OF BENZOIC ACID AND SODIUM BENZOATE AS FOOD INGREDIENTS. OHEW.
WASHINGTON. DC. REPORT NO. SCOGS-7 NTIS PB-223 837/6. P.17.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BENZOIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.

US EPA. 1987. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

BENZYL ALCOHOL 000100-51-6
005855 NTP (NATIONAL TOXICOLOGY PROGRAM). 1988 TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ALCOHOL (CAS NO 100-51-6) IN F344/NRATS AND
B6C3F1 MICE (GAVAGE STUDIES) NTP TECHNICAL REPORT. NTP TR 343. P 1-161.

005856 NTP (NATIONAL TOXICOLOGY PROGRAM) 1988. TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ALCOHOL (CAS NO 100-51-6) IN F344/NRATS AND
B6C3F1 MICE (GAVAGE STUDIES). NTP TECHNICAL REPORT. NTP TR 343. P 1-161.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BENZYL ALCOHOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

BERYLLIUH 007440-41-7
005262 SCHROEDER HA AND M MITCHNER. 1975 LIFE-TERM STUDIES IN RATS: EFFECTS OF ALUMINUM. BARIUM. BERYLLIUM AND TUNGSTEN. J NUTR. 105: 421-427.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR BERYLLIUM PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

BIPHENYL, 1.1' 000092-52-4
005857 AMBROSE AM. AN BOOTH. F DE EDS AND AJ COS JR 1960 A TOXICOLOGICAL STUDY OF BIPHENYL. A CITRUS FUNGISTAT. FOOD RES. 25: 328-336.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.1'-BIPHENYL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

010878 US EPA. 1990. RfD/RfC WORK GROUP.

BIS(2-CHLOROISOPROPYL) ETHER 039638-32-9
010257 MITSUMORI K. T USUI. K TAKAHASHI. AND Y SHIRASU. 1979. TWENTY-FOUR MONTH CHRONIC TOXICITY STUDIES OF DICHLORODIISOPROPYL ETHER IN MICE
NIPPON NOYAKU GAKKAISHI. 4(3)- 323-335

US EPA. 1989. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

BIS(2-ETHYLHEXYL) PHTHALATE / (DEHP) 000117-81-7
010859 CARPENTER. CP. CS WEIL AND HF SMYTH 1953 CHRONIC ORAL TOXICITY OF DK2-ETHYLHEXYL) PHTHALATE FOR RATS. GUINEA PIGS AND DOGS. ARCH IND
HYG OCC MED. 8: 219-226.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP

BISPHENOL A 000080-05-7
005268 NTP (NATIONAL TOXICOLOGY PROGRAM) 1982. CARCINOGENESIS BIOASSAY OF BISPHENOL A IN F344 RATS AND B6C3F1 MICE (FEED STUDY) NTP TECH REP
SER. NO. 80-35 NTIS PB 84-1555308 P. 192.

US EPA. 1988. RfD/RfC WORK GROUP.

005266 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF BISPHENOL A IN F344 RATS AND B6C3F1 MICE (FEED STUDY) NTP TECH REP
SER. NO. 80-35 NTIS PB 84-1555308 P 192

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BISPHENOL A. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

BORON TRIFLUORIDE 007637-07-2
010395 RUSCH GM. GM HOFFMAN. RF MCCONNELL ET AL. 1986. INHALATION TOXICITY STUDIES WITH BORON TRIFLUORIDE. TOXICOL APPL PHARMACOL. 83: 69-78.

US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BORON AND BORON COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

BORON. ELEMENTAL 007440-42-8
005272 WEIR RJ. JR AND RS FISHER. 1972. TOXICOLOGIC STUDIES ON BORAX AND BORIC ACID. TOXICOL APPL PHARMACOL. 23(3): 351-364.

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR BORON AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

US EPA 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR BORON. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

005269 GARABRANT DH. L BERNSTEIN. JM PETERS ET AL. 1985. RESPIRATORY EFFECTS OF BORAX DUST. BR J IND MED. 42: 831-837.

US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BORON AND BORON COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

BROMINATED DIBENZO-P-DIOXINS
005858 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZOFURANS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

BROMINATED DIBENZOFURANS
005859 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZOFURANS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC

BROMOACETONE 000598-31-2
005860 US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOACETONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

BROMOCHLOROETHANES
005861 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOCHLOROETHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

BROMODICHLOROMETHANE 000075-27-4
005715 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICITY AND CARCINOGENICITY STUDIES OF BROMODICHLOROMETHANE IN F344/N RATS AND B6C3F1 MICE
(GAVAGE STUDIES). NTP TECH REPORT. SER NO 321. NIH PUB NO 87-2537.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

BROMOETHENE / (VINYL BROMIDE) 000593-60-2
010929 BENYA TJ. WM BUSEY. MA OORATO AND PE BERTEAU 1982. INHALATION CARCINOGENICITY BIOASSAY OF VINYL BROMIDE IN RATS. TOXICOL APPL PHARMACOL.
64(3): 367-379.

BUSEY WM. 1979. ONCOGENIC POTENTIAL OF VINYL BROMIDE DURING CHRONIC INHALATION EXPOSURE -- RATS: PATHOLOGY REPORT. EPA/OTS
8EHQ-0479-0281.

US EPA. 1993. RfD/RfC WORK GROUP.

BROMOFORM 000075-25-2
005722 NTP (NATIONAL TOXICOLOGY PROGRAM) 1989 TOXICOLOGY AND CARCINOGENICITY STUDIES OF TRIBROMOMETHANE AND BROMOFORM IN F344 RATS AND B6C3F1
MICE (GAVAGE STUDIES). NTP-350.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. HEALTH AND ENVIRONMENTAL ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE WASHINGTON.
DC.

US EPA. 1987. RfD/RfC WORK GROUP.

010961 US EPA. 1993. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
May 1995
BROMOMETHANE
010861
DANSE LH. FL VAN VELSEN AND CA VAN DER HEIJDEN
PHARMACOL. 72- 262-271.
000074-83-9
1984. METHYL BROMIDE: CARCINOGENIC EFFECTS IN THE RAT FORESTOMACH. TOXICOL APPL
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR BROMOMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL BROMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID HASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. RfO/RfC WORK GROUP.

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR BROMOMETHANE. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

010860 REUZEL. PGJ. CF KUPER. HC DREEF-VAN DER MEULEN. VMH HOLLANDERS. 1987. CHRONIC (29 MONTH) INHALATION TOXICITY AND CARCINOGENICITY STUDY OF
METHYL BROMIDE IN RATS. REPORT NO V86.469/221044. NETHERLANDS ORGANIZATION FOR APPLIED SCIENTIFIC RESEARCH. DIVISION FOR NUTRITION AND
FOOD RESEARCH. TNO. EPA/OTS DOCUMENT #86-8700001202.

REUZEL. PGJ. HC DREEF-VANDER MEULEN. VMH HOLLANDERS. CF KUPER. VJ FERON. CA VAN DER HEIJDEN. 1991. CHRONIC INHALATION TOXICITY AND
CARCINOGENICITY STUDY OF METHYL BROMIDE IN WISTAR RATS. FOOD CHEM. TOXICOL. 29(1): 31-39.

US EPA. 1991. RfD/RfC WORK GROUP.

BROMOPHENYL PHENYL ETHER. 4- 000101-55-3
005864 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-BROMOPHENYL PHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

BROMOPHOS 002104-96-3
005865 LEUSCHNER F. A LEUSCHNER AND E POPPE 1967. CHRONISCHER REPROOUKTIONSVERSUCH UBER 3 GENERATIONEN AN WISTAR-RATTEN BEI FORTDAUERNER
VERABREICHUNG VON BROMOPHOS. REPORT CH BOEHRINGER SOHN. (UNPUBLISHED).

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

BROMOXYNIL 001689-84-5
005866 UNION CARBIDE AGRICULTURE PRODUCTS. INC. 1982. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY MRID NO 00096521 AVAILABLE FROM
EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

BROMOXYNIL OCTANOATE 001689-99-2
005867 UNION CARBIDE AGRICULTURE PRODUCTS. INC. 1982. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY MRID NO 00096521 AVAILABLE FROM
EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL OCTANOATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

BUSAN 77 031512-74-0
005868 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 77. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

BUSAN 90 002491-38-5
005869 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 90. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.'

BUTANOL. 1- 000071-36-3
005870 US EPA. 1986. BUTANOL: RAT ORAL SUBCHRONIC TOXICITY STUDY. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. HEALTH AND ENVIRONMENTAL-EFFECTS DOCUMENT FOR 1-BUTANOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

BUTYL BENZYL PHTHALATE. N- 000085-68-7
005616 NTP (NATIONAL TOXICOLOGY PROGRAM) 1985 PROJECT NO 12307-02. -03. HAZELTON LABORATORIES AMERICA. INC. UNPUBLISHED STUDY.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC.

US EPA 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS (PAE)S. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BUTYL BENZYL PHTHALATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP

BUTYLATE 002008-41-5
005871 STAUFFER CHEMICAL COMPANY. 1987. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO. 40289101. AVAILABLE FROM EPA. WRITE TO
FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUTYLATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

BUTYLCHLORIDE. T- 000507-20-0
005810 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

BUTYROLACTONE. GAMMA- 000096-48-0
005872 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUTYROLACTONE. GAMMA. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CACODYLIC ACID 000075-60-5
005873 NEES PO. 1968. REPORT ON CACODYLIC ACID TOXICITY TO ANIMALS WISCONSIN ALUMNI RES FOUND. EPA PESTICIDE PETITION NO OF 0911.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CACODYLIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

CADMIUM 007440-43-9
005280 US EPA. 1985. DRINKING WATER CRITERIA DOCUMENT ON CADMIUM. OFFICE OF DRINKING WATER. WASHINGTON. DC. FINAL DRAFT.

US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CADMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON. DC.
EPA-440/5-80-025.

US EPA. 1988. RfD/RfC WORK GROUP.

CALCIUM CYANIDE 000592-01-8
010258 HOWARD JW AND RF HANZAL. 1955 CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.

PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS. J
TOXICOL ENVIRON HEALTH. 5: 579-592.

US EPA. 1985. RfD/RfC WORK GROUP.

CAPROLACTAM 000105-60-2
005284 SEROTA DG. AM HOBERMAN AND SC GAD. 1984. A THREE-GENERATION REPRODUCTION STUDY WITH CAPROLACTAM IN RATS. IN: PROCEEDINGS OF A SYMPOSIUM
ON AN INDUSTRY APPROACH TO CHEMICAL RISK ASSESSMENT: CAPROLACTAM AND RELATED COMPOUNDS AS A CASE STUDY. INDUSTRY HEALTH FOUND ARLINGTON
VA.. P 191-204.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CAPROLACTAM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

005282 POWERS WJ. JR. JC PECKHAM. KM SIINO AND SC GAD 1984. EFFECTS OF SUBCHRONIC DIETARY CAPROLACTAM ON RENAL FUNCTION. IN: PROCEEDINGS OF A
SYMPOSIUM ON AN INDUSTRY APPROACH TO CHEMICAL RISK ASSESSMENT: CAPROLACTAM AND RELATED COMPOUNDS AS A CASE STUDY INDUSTRY HEALTH FOUND
ARLINGTON. VA.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CAPROLACTAM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

010966 US EPA. 1994. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

CAPTAFOL 002425-06-1
005874 ORTHO-CHEVRON CHEMICAL COMPANY. 1985. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY ACCESSION NO 260671 MRID NO 00149488
00155196. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAFOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.'

US EPA. 1987. RFD/RFC WORK GROUP.

CAPTAN 000133-06-2
005875 CHEVRON CHEMICAL COMPANY. 1982. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 00125293 AVAILABLE FROM EPA WRITE TO
FOI. EPA. WASHINGTON. DC 20460. ' '

STAUFFER CHEMICAL COMPANY. 1982 CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 00120315 AVAILABLE FROM EPA WRITE TO
FOI. EPA. WASHINGTON. DC 20460. ' '

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP

CARBARYL 000063-25-2
005876 CARPENTER CP. CW WEIL. PE POLIN. ET AL 1961. MAMMALIAN TOXICITY OF 1-NAPHTHYL-N-METHYLCARBAMATE (SEVIN INSECTICIDE). J AGRIC FOOD CHEM
9: 30-39.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBARYL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.'

US EPA. 1985. RfD/RfC WORK GROUP.

010882 US EPA. 1991. RfD/RfC WORK GROUP.

CARBOFURAN 001563-66-2
005877 FMC CORPORATION. 1983. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. ACCESSION NO 250740-250755 MRID NO 00129507 AVAILABLE
FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460. ' ' «wuuwi.t

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBOFURAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC. '

US EPA. 1987. RfD/RfC WORK GROUP.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

CARBON DISULFIDE 000075-15-0
010259 HARDIN BD. GP BOND. MR SIKOR. FD ANDREW. RP BELILES AND RW NIEMEIR. 1981. TESTING OF SELECTED WORKPLACE CHEMICALS FOR TERATOGENIC
POTENTIAL. SCAND J WORK ENVIRON HEALTH 7CSUPPL 4): 66-75.

US EPA. 1985. RfD/RfC WORK GROUP.

010430 TABACOVA S. LA HINKOVA. L BALABAEVA 1978 CARBON DISULFIDE TERATOGENICITY AND POSTNATAL EFFECTS IN RATS. TOXICOL LETT. 2(3): 129-133.

TABACOVA S. B NIKIFOROV. L BALABAEVA 1983 CARBON DISLUFIDE INTRAUTERINE SENSITIZATION. J APPL TOXICOL. 3(5): 233-239.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBON DISULFIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

CARBON MONOXIDE 000630-05-0
010493 REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

CARBON TETRACHLORIDE 000056-23-5
010862 BRUCKNER. JV. WF MACKENZIE. S MURALIDHARA. ET AL. 1986. ORAL TOXICITY OF CARBON TETRACHLORIDE- ACUTE SUBACUTE AND SUBCHRONIC STUDIES IN
RATS. FUND APPL TOXICOL. 6(1): 16-34.

US EPA. 1985. RfD/RfC WORK GROUP

CHLORAL 000075-87-6
005290 SANDERS VM. BM KAUFFMANN. KL WHITE. JR 1982 TOXICOLOGY OF CHLORAL HYDRATE IN THE MOUSE. ENVIRON HEALTH PERSPECT. 44: 146-173.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORAL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.'

US EPA. 1988. RfD/RfC WORK GROUP

CHLORDANE 000057-74-9
005296 VELSICOL CHEMICAL CORP. 1983. ACC NO 252267. MRID NO. 00138591, 00144313. AVAILABLE FROM EPA. WRITE TO FOI. EPA, WASHINGTON. DC 20460.

US EPA. 1989. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

CHLORINE CYANIDE 000506-77-4
010261 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.

PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS. J
TOXICOL ENVIRON HEALTH 5- 579-592

US EPA. 1985. RfD/RfC WORK GROUP

CHLORO-1.3-BUTADIENE. 2- / (CHLOROPRENE) 000126-99-8
010515 NTP (NATIONAL TOXICOLOGY PROGRAM) 1988 SUBCHRONIC INHALATION TOXICITY STUDY OF CHLOROPRENE IN MICE AND RATS. CONDUCTED BY
BATELLE PACIFIC NORTHWEST LABORATORY. HIGHLAND. WA

US EPA. 1992. RfD/RfC WORK GROUP

CHLORO-M-CRESOL. P- 000059-50-7
005366 MADSEN C. PH ANDERSEN. 0 MEYER AND G WURTZEN 1986 4-CHLORO-E-METHYLPHENOL: SALMONELLA/MAMMALIAN-MICROSOME MUTAGENICITY TEST AND
SUBACUTE TOXICITY TEST IN RATS BULL ENVIRON CONTAM TOXICOL. 37(5): 651-654.

US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR P-CHLORO-M-CRESOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CHLOROACETALDEHYDE 000107-20-0
005342 US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROACETALOEHYDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CHLOROACETIC ACID 000079-11-8
005346 IRDC (INTERNATIONAL RESEARCH AND DEVELOPMENT CORPORATION). 1982. SUBCHRONIC ORAL TOXICITY TEST WITH MONOCHLOROACETIC ACID IN RATS.
NATIONAL TOXICOLOGY PROGRAM. BETHESDA. MD P 1-101.

US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROACETIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CHLOROANILINE. 2- 000095-51-2
005347 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

CHLOROANILINE. 3- 000108-42-9
005348 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

CHLOROANILINE. 4- 000106-47-8
005349 NCI (NATIONAL CANCER INSTITUTE). 1979 BIOASSAY OF P-CHLOROANILINE FOR POSSIBLE CARCINOGENICITY NCI CARC TECH REP SER NO 189 NTIS
PB-295896. ' •

US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP

CHLOROBENZENE 000108-90-7
010863 MONSANTO COMPANY. 1967. 13-WEEK ORAL ADMINISTRATION--DOGS. MONOCHLOROBENZENES. FINAL REPORT. PROJECT NO 241-105 FEBRUARY 24 PREPARED
BY HAZELTON LABORATORIES.

KNAPP. WK. WM BUSEY. AND W KUNDZINS 1971. SUBACUTE ORAL TOXICITY OF MONOCHLOROBENZINE IN DOGS AND RATS TOXICOL APPL PHARMACOL 19- 393
(ABSTRACT).

US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR CHLORINATED BENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. EPA 600/8-84-015F. NTIS PB85-150332.

US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHOLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP

CHLOROBENZILATE 000510-15-6
010260 CIBA-GEIGY CORPORATION. 1984. MRID NO 00144691. AVAILABLE FROM'EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROBENZILATE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE. OFFICE OF HEATH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.

US EPA. 1989. RfD/RfC WORK GROUP

010931 US EPA. 1993. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

CHLOROBENZOIC ACID. P- 000074-11-3
005360 KIECKEBUSCH W. W GRIEM AND K LANG. 1960. THE TOLERABILITY OF P-CHLOROBENZOIC ACID. ARZNEIMI HEL-FORSCH. 10: 999-10001.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR P-CHLOROBENZOIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CHLOROBENZOTRIFLUORIDE. 4- 000098-56-6
005364 HOOKER CHEMICAL CORP. 1981. MODIFIED 90-DAY GAVAGE AND REPRODUCTION STUDY IN RATS PCBTF. CONDUCTED BY ELARS BIORESEARCH LABORATORIES.
INC. FORT COLLINS. CO. US EPA/OPTS PUBLIC FILES. MICROFICHE #OTS0508148.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4-CHLOROBENZOTRIFLUORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CHLOROBUTANE. 1- 000109-69-3
005808 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF N-BUTYL CHLORIDE IN F344/N RATS AND B6C3F1
MICE (GAVAGE STUDIES). CAS NO 109-69-3. NTP-TR-312. 198 P.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

005806 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF N-BUTYL CHLORIDE IN F344/N RATS AND B6C3F1 MICE (GAVAGE
STUDIES). CAS NO 109-69-3. NTP-TR-312. 198 P.

CHLOROBUTANE. 2- 000078-86-4
005809 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CHLOROCYCLOPENTADIENE 041851-50- 7
005297 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

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(OTHER THAN CARCINOGENICITY)
Hay 1995
CHLOROFORM 000067-66-3
005372 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTIDIENES PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

CHLOROMETHANE (METHYL CHLORIDE) 000074-87-3
010005 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASH!NGTON. DC.

CHLORONITROBENZENE. M- 000121-73-3
005879 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC. ,
CHLOROPHENOL. 2-
010436 EXON JH. LD KOELLER.
000095-57-8
1982. EFFECTS OF TRANSPLACENTAL EXPOSURE TO CHLORINATED PHENOLS. ENVIRON HEALTH PERSPECT. 46: 137-140.
CHLOROPHENOL,
005309
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2.4-DICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
UL..

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-CHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

3- . 000108-43-0
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
CHLOROPHENOL. 4- 000106-48-9
005310 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
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(OTHER THAN CARCINOGENICITY) Hay 1995
WASHINGTON. DC.
CHLOROPROPANE 2- 000075-29-6
010444 GAGE JC. 1970. THE SUBACUTE INHALATION TOXICITY OF 109 INDUSTRIAL CHEMICALS. BR J IND MED. 27(1): 1-18.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2 -CHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

f HI OROTHALON I L 00 1897 - 45 - 6
005883 DIAMOND SHAMROCK CHEMICAL COMPANY. 1970. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. ACCESSION NO 111253. MRID NO. 00057702.
00114034. AVAILABLE FROM EPA. WRITE TO FOI . EPA. WASHINGTON. DC 20460.

US EPA 1986. RfD/RfC WORK GROUP.

PHI OROTOI UENE M - 000108 - 41 - 8
005880 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROTOLUENES . PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

PHI OROTOLUENE 0- 000095-49-8
010167 GIBSON WR FO GOSSETT GR KOENIG F MARROQUIN. 1974. THE TOXICITY OF DAILY ORAL DOSES OF 0-CHLOROTOLUENE IN THE RAT. TOXICOLOGY
010167 ™WR SUBMITTED T0 TEST RULES DEVELOPMENT BRANCH. OFFICE OF TOXIC SUBSTANCES. US EPA. WASHINGTON. DC.
US EPA. 1989. RfD/RfC WORK GROUP.

PHI OROTOI UENE P- 000106-43-4
010200 'US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHOROTOLUENES . PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHLORPYRIFOS 002921-88-2
005881 DOW CHEMICAL COMPANY. 1972. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. ACCESSION NO 112118.

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORPYRIFOS AND CHLOROPYRIFOS-METHYL. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC.

US EPA. 1986. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

CHLORPYRIFOS METHYL 005598-13-0
005882 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORPYRIFOS AND CHLORPYRIFOS-METHYL PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

CHLORTHIOPHOS 060238-56-4
005884 WORTHING CR AND SB WALKER. ED. 1983. THE PESTICIDE MANUAL. 7TH ED. BRITISH CROP PROTECTION COUNCIL. THE LAVENHAM PRESS LTD SUFFOLK
ENGLAND. P 130.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORTHIOPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHROMIUM(III) 016065-83-1
005731 IVANKOVIC S AND R PREUSSMAN. 1975 ABSENCE OF TOXIC AND CARCINOGENIC EFFECTS AFTER ADMINISTRATIONS OF HIGH DOSES OF CHROMIC OXIDE PIGMENT
IN SUBACUTE AND LONG-TERM FEEDING EXPERIMENTS IN RATS. FOOD COSMET TOXICOL 13: 347-351.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR TRIVALENT CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

CHROMIUM(VI) 018540-29-9
005522 MACKENZIE RD. RU BYERRUM. CF DECKER ET AL. 1958. CHRONIC TOXICITY STUDIES. II. HEXAVALENT AND TRIVALENT CHROMIUM ADMINISTERED IN DRINKING
WATER TO RATS. AM MED ASSOC ARCH IND HEALTH 18 232-234.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXAVALENT CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

CHRYSENE 000218-01-9
005885 US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHRYSENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.'

COPPER 007440-50-8
005374 US EPA. 1987. DRINKING WATER CRITERIA DOCUMENT FOR COPPER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

COPPER CYANIDE 000544-92-3
010262 US EPA. 1986. 90 DAY ORAL TOXICITY STUDY OF COPPER CYANIDE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

CRESOL. M- / (3-METHYLPHENOL) 000108-39-4
005380 US EPA. 1986. O.M.P-CRESOL. 90-DAY ORAL SUBCHRONIC TOXICITY STUDIES IN RATS OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. O.M.P-CRESOL. 90-DAY ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS. OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

010888 US EPA. 1991. RfD/RfC WORK GROUP.

CRESOL. 0- / (2-METHYLPHENOL) 000095-48-7
005384 US EPA. 1986. O.M.P-CRESOL. 90-DAY ORAL SUBCHRONIC TOXICITY STUDIES IN RATS. OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. O.M.P-CRESOL. 90-DAY ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS. OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

010889 US EPA. 1991. RfD/RfC WORK GROUP.

CRESOL. P- / (4-METHYLPHENOL) 000106-44-5
010516 CMA (CHEMICAL MANUFACTURERS' ASSOCIATION). 1988. DEVELOPMENTAL TOXICITY EVALUATION OF 0-. M- OR P-CRESOL ADMINISTERED BY GAVAGE TO NEW
ZEALAND WHITE RABBITS. FINAL PROJECT REPORT 51-508. FICHE NO. OTS0517695.

DEITZ D. AND LT MULLIGAN. 1988. SUBCHRONIC TOXICITY OF P-CRESOL IN SPRAGUE-DAWLEY RATS: MBA CHEMICAL NO 25. PREPARED BY RESEARCH TRIANGLE
INSTITUTE. RESEARCH TRIANGLE PARK. NC. PREPARED FOR EPA. WASHINGTON. DC.

US EPA. 1993. RfD/RfC WORK GROUP.

010890 US EPA. 1991. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

CUMENE 000098-82-8,
005392 WOLF MA. VK ROME, DO MCCOLLISTER. RL HOLLINGSWORTH AND F OYEN. 1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND BENZENES AHA
ARCH IND HEALTH. 14: 387-398.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CUMENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

005908 MONSANTO COMPANY. 1986. ONE MONTH STUDY OF CUMENE VAPOR ADMINISTERED TO MALE AND FEMALE SPRAGUE-DAWLEY RATS BY INHALATION US EPA/OTS
PUBLIC FILES. 8D SUBMISSION. MICROFICHE* OTS 0513229.

CYANAZINE 021725-46-2
010411 El DU PONT DE NEMOURS AND COMPANY. INC. 1986. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY MRID NO 40081901 AND 40229001
AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYANAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1992. RfO/RfC WORK GROUP.

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR CYANAZINE. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

CYANIDE 000057-12-5
005396 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. J AGRIC FOOD CHEM. 3: 325-329.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR CYANIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR CYANIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

CYANOGEN 000460-19-5
010263 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE AGRIC FOOD CHEM. 3: 325-329.

US EPA. 1985. RfD/RfC WORK GROUP.

CYANOGEN BROMIDE 000506-68-3
010264 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.

US EPA. 1987. RfD/RfC WORK GROUP.

CYCLOATE 001134-23-2
005886 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.

CYCLOHEXANOL 000108-93-0
005887 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOHEXANOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. OC.

CYCLOHEXYLAMINE 000108-91-8
005400 GAUNT IF. J HARDY. P GRASSO. SD GANGOLLI AND KR BUTTERWORTH 1976. LONG-TERM TOXICITY OF CYCLOHEXYLAMINE HYDROCHLOR1DE IN THE RAT. FOOD
COSMET TOXICOL. 14(4): 255-268.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA"AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

005398 GAUNT IF. M SHARRATT. PG GRASSO. AB LANSDOWN AND SD GANGOLLI 1974 SHORT-TERM TOXICITY OF CYCLOHEXYLAMINE HCL IN THE RAT. FOOD COSMET
TOXICOL. 12: 609-624.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

CYCLOPENTADIENE 000542-92-7
010494 DOW. 1987. UNPUBLISHED DATA. DOW CHEMICAL USA. MIDLAND. MI.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC.

DACTHAL 001861-32-1
005888 ISK BIOTECH CORPORATION. 1993. MRID NO. 42731001. 42998401. HED DOC NO 010513 AVAILABLE FROM EPA WRITE TO FOI EPA WASHINGTON DC
20460.

US EPA. 1994. RfD/RfC WORK GROUP.

DALAPON 000075-99-0
005889 PAYNTER OE. TW TUSING. DD MCCOLLISTER AND VK ROWE. 1960. TOXICOLOGY OF DALAPON SODIUM (2 2-DICHLOROPROPIONIC ACID SODIUM SALT) J AGRIC
FOOD CHEM. 8: 47-51.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DALAPON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

DOT 000050-29-3
005408 LAUG. EP. AA NELSON. OG FITZHUGH AND FM KUNZE. 1950. LIVER CELL ALTERATION AND DDT STORAGE IN THE FAT OF THE RAT INDUCED BY DIETARY
LEVELS OF 1-50 PPM DDT. J PHARMACOL EXP THERAP. 98: 268-273.

US EPA. 1985. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DECABROHODIPHENYL ETHER 001163-19-5
005891 KOCIBA RJ. LO FRAUSON. CG HUMISTON. ET AL. 1975. RESULTS OF A TWO-YEAR DIETARY FEEDING STUDY WITH DECABROMODIPHENYL OXIDE (DCDPO) IN
RATS. COMBUST TOXICOL. 2(4): 267-285.

MORRIS JM. JW EHRMANTRAUT. a GIBBONS. ET AL. 1975. TOXICOLOGY OF OCTABROMOBIPHENYL AND OECABROMODIPHENYL OXIDE. ENVIRON HEALTH PERSPECT.
11:153-161.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

DI-N-OCTYL PHTHALATE 000117-84-0
010275 PIEKACZ H. 1971. EFFECT OF DIOCTYL AND DIBUTYL PHTHALATES ON THE ORGANISM OF RATS AFTER ORAL ADMINISTRATION IN PROLONGED EXPERIMENT. II
SUBACUTE AND CHRONIC TOXICITY. ROCZ PANSTW ZAKL HIG. 22(3): 295-307.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACID. ALKYL. ARYL. AND ALKYL/ARYL ESTERS. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE.
WASHINGTON. DC.

DIAZINON 000333-41-5
005892 DAVIES DB AND BJ HOLUB. 1979. COMPARATIVE SUSCEPTIBILITY OF MALE AND FEMALE RATS TO DIETARY DIAZINON TOXICITY. J NUTR. 109(6): XXVIII.

DAVIES DB AND BJ HOLUB. 1980. COMPARATIVE SUBACUTE TOXICITY OF DIETARY DIAZINON IN THE MALE AND FEMALE RAT. TOXICOL APPL PHARMACOL
54(3): 359-367.

DAVIES DB AND BJ HOLUB. 1980. TOXICOLOGICAL EVALUATION OF DIETARY DIAZINON IN THE RAT. ARCH ENVIRON CONTAM TOXICOL. 9(6). 637-650.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIAZINON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

DIBENZOFURAN 000132-64-9
005409 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DIBENZOFURAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DIBROHOBENZENE. 1.4- 000106-37-6
005893 CARLSON GP AND RG TARDIFF. 1977. EFFECT OF 1.4-DIBROMOBENZENE AND 1.2.4-TRIBROMOBENZENE ON XENOBIOTIC METABOLISM. TOXICOL APPL PHARMACOL.
42(1): 189-196.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

DIBROMOCHLOROMETHANE 000124-48-1
005894 NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORODIBROMOMETHANE IN F344/N RATS AND B6C3F1 MICE
(GAVAGE STUDIES). NTP TR282. NTIS PB86-166675.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOCHLOROMETHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIBROMOCHLOROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

DIBRONOETHANE. 1.2- 000106-93-4
010854 RATCLIFFE JM. SM SCHRADER. K STEENLAND. DE CLAPP. T TURNER AND RW HORNUNG. 1987. SEMEN QUALITY IN PAPAYA WORKERS WITH LONG-TERM EXPOSURE
TO ETHYLENE BROMIDE. BR J IND MED. 44: 317-326.

SCHRADER SM. TW TURNER AND JM RATCLIFFE. 1988. THE EFFECTS OF ETHYLENE BROMIDE ON SEMEN QUALITY: A COMPARISON OF SHORT-TERM AND CHRONIC
EXPOSURE. REPROD TOXICOLOGY. 2: 191-198.

US EPA. 1992. RFD/RFC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN I CITY) ^ 1995

DIBUTYL PHTHALATE 000084-74-2
005622 SMITH CC. 1953. TOXICITY OF BUTYL STEARATE. DIBUTYL SEBACATE. DIBUTYL PHTHALATE AND METHOXYETHYL OLEATE ARCH HYG OCCUP MED 7 310-318

US EPA. 1990. RfD/RfC WORK GROUP.

010892 US EPA. 1990. RfD/RfC WORK GROUP.

DICAMBA 001918-00-9
010945
CITED A5 VELSICOL CHEMICAL CORPORATION (1978) IN U.S. EPA (1993). MRID 00028236. AVAILABLE FRo EA WR TO Si E?A. LsS?S DC
US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR DICAMBA PRFPARFn RY THF OFPTPF nr u«i TU
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. cST!« TO THE^ICE OF^ra 2sH?NGTON. Sc
US EPA. 1988. RfD/RfC WORK GROUP.

DICHLOROBENZENE. 1.2- 000095-50-1
010864 US EPA. 1989. RfD/RfC WORK GROUP.

DICHLOROBENZENE, 1.3- 000541-73-1
005414 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DICHLOROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE

US EPA. 1992. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DICHLOROBENZENE. 1.4- 000106-46-7
010840 CHLOROBENZENE PRODUCERS ASSN. 1986. PARADICHLOROBENZENE: TWO-GENERATION REPRODUCTION STUDY IN SPRAGUE-DAWLEY RATS. STUDY N086-81-90605.
MRID NO 411088-1. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

NTP (NATIONAL TOXICOLOGY PROGRAM). 1987. TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.4-DICHLOROBENZENE IN F344/N RATS AND 86C3F1 MICE
(GAVAGE STUDIES). NTP TR 319. NIH PUBL NO 87-2575.

US EPA. 1992. RfD/RfC WORK GROUP.

OICHLOROBUTENES
005415 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DICHLOROBUTENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DICHLORODIFLUOROMETHANE 000075-71-8
005498 SHERMAN H. 1974. LONG-TERM FEEDING STUDIES IN RATS AND DOGS WITH DICHLORODIFLUOROMETHANE (FREON 12 FOOD FREEZANT) HASKELL LABORATORY
REPORT NO 24-74. UNPUBLISHED. COURTESY DU PONT DE NEMOURS CO.

US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

US EPA. 1985. RfD/RfC WORK GROUP.

005496 CLAYTON WJ. JR. 1967. FLUOROCARBON TOXICITY AND BIOLOGICAL ACTION. FLUORINE CHEM REV. 1(2). 197-252.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

DICHLOROETHANE, 1.1- 000075-34-3
005790 HOFMANN HT. H BIRNSTIEL AND P JOBST. 1971. ON THE INHALATION TOXICITY OF 1.1- AND 1.2-DICHLOROETHANE. ARCH TOXIKOL. 27: 248-265.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DICHLOROETHYLENE. 1.1- 000075-35-4
005419 ' ™ m oraaicnv STUOY IN ™ « SUBCHRONIC TOXICITY S™Y IN
»c HEALTH EFFKTS A551155^7 FOR LI -DICHLOROETHYLENE (VINYLIDINE CHLORIDE). PREPARED BY THE OFFICE OF HEALTH AND
r SMENT> ENVIRONMENTAL CRITERIA A"0 ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE
. DC.
US EPA. 1989. RfD/RfC WORK GROUP.

DICHLOROETHYLENE. 1.2- (MIXED ISOMERS) 000540-59-0
010509 T "1^ " oraaicnY STUDY IN "ws m SUBCHRONIC TOXICITY STUOY I
US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.2-DICHLOROETHYLENE (MIXED ISOMERS) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE . WASH I NGTON . DC .
DICHLOKOETHYLBIE. 1.2-C- 000156-59-2
005420 """™ "^ " *KmaiK ^ amm ™"s-'-"«««™™ ••
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1.2-C-DICHLOROETHYLENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REM^IAiTsPONSE^HINGTON ^

US EPA. 1990. RfD/RfC WORK GROUP.

DICHLOROETHYLENE. 1.2-T- 000156-60-5
005895 BARNES DW. MM SANDERS. KL SHITE JR. ET AL. 1985. TOXICOLOGY OF TRANS- 1.2-DICHLOROETHYLENE IN THE MOUSE. DRUG CHEM TOXICOL. 8: 373-392.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1.2-T-DICHLOROETHYLENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE^ASHINGTON DC

DICHLOROPHENOL. 2.3- 000576-24-9
005315 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE™
WASH I NGTON , DC .
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DICHLOROPHENOL. 2.4- 000120-83-2
005314 EXON JH. AND LD KOLLER. 1985. TOXICITY OF 2-CHLOROPHENOL.2.4-OICHLOROPHENOL AND 2.4.6-TRICHLOROPHENOL. IN: WATER CHLORINATION: CHEM.
ENVIRON IMPACT AND HEALTH EFF. JOLLEY ET AL.. ED. VOL. 5.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2.4-DICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
DC.

US EPA. 1986. RfD/RfC WORK GROUP.

DICHLOROPHENOL. 2.5- 000583-78-8
005316 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DICHLOROPHENOL. 2.6- 000087-65-0
005317 US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

DICHLOROPHENOL. 3.4- 000095-77-2
005318 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DICHLOROPHENOL. 3.5- 000591-35-5
005319 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DICHLOROPHENOXY ACETIC ACID. 2.4- 000094-75-7
010265 DOW CHEMICAL CO. 1983. ACC NO. 251473.

US EPA. 1988. RfD/RfC WORK GROUP.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DICHLOROPHENOXY) BUTYRIC ACID. 4-(2.4- / (2.4-DB) 000094-82-6
005890 RHOOIA INC. 1969. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRIO NO. 0092165 AVAILABLE FROM EPA WRITE TO FOI EPA
WASHINGTON, DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-DB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DICHLOROPROPANE. 1.1- 000078-99-9
005897 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

DICHLOROPROPANE. 1.2- 000078-87-5
005898 NITSCHKE KD. KA JOHNSON. DL WACKERLE. JE PHILLIPS. DA DITTENBER. 1988. PROPYLENE DICHLORIDE: A 13 WEEK INHALATION TOXICITY STUDY WITH
RATS. MICE AND RABBITS. DOW CHEMICAL CO. MAMMALIAN AND ENVIRONMENTAL TOXICOLOGY RESEARCH LABORATORY. MIDLAND. MI.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1991. RfD/RfC WORK GROUP.

DICHLOROPROPANE. 1.3- 000142-28-9
005899 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

DICHLOROPROPANE. 2.2- 000594-20-7
005900 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

DICHLOROPROPENE. 1.3- / (TELONE II) 000542-75-6
005901 DOW CHEMICAL CO. 1973. MRID NOS. 00067977. 0039684. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3-OICHLOROPROPENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR 1.3-DICHLOROPROPENE. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON,
DC.

010351 LOMAX. LG. WT STOTT. KA JOHNSON. ET AL. 1989. THE CHRONIC TOXICITY AND ONCOGENICITY OF INHALED TECHNICAL-GRADE 1.3-DICHLOROPROPENE IN
RATS AND MICE. FUND APPL TOXICOL. 10: 214.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3-DICHLOROPROPENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.

DICHLORPROP 000120-36-5
005896 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROP. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DICYCLOPENTADIENE 000077-73-6
005425 LITTON BIONETICS. INC. 1980. MAMMALIAN TOXICOLOGICAL EVALUATION OF DIMP AND DCPD. (PHASE 2). LITTON BIONETICS. INC.. KENSINGTON. MD
CONTRACT DAMB. 17-77-C-7003. NTIS AD-A082685

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

DIELDRIN 000060-57-1
005429 WALKER AIT. DE STEVENSON. J ROBINSON. ET AL. 1969. THE TOXICOLOGY AND PHARMACODYNAMICS OF DIELDRIN (HEOD): TWO-YEAR ORAL EXPOSURE OF RATS
AND DOGS. TOXICOL APPL PHARMACOL. 15: 345-373.

US EPA. 1987. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DIETHYL PHTHALATE 000084-66-2
005620 BROWN D. KR BUTTERWORTH. IF GAUNT ET AL. 1978. SHORT-TERMORAL TOXICITY STUDY OF DIETHYL PHTHALATE IN THE RAT FOOD COSMET TOXICOL 16
415-422.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE WAS™ON DC
rnrrn™ CRITERIA ^^ FOR PHTHALIC *W ESTERS (PAE)S PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH. FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

DIETHYL-P-NITROPHENYL PHOSPHATE 000311-45-5
005922 US EPAJ989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIETHYL-P-NITROPHENYL PHOSPHATE. PREPARED BY THE OFFICE OF HEALTH AND
J- ENVIRONMENTAL CRITERIA A*0 ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
. DC.
DIETHYLANILINE. N,N- 000091-66-7
005903 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIETHYLANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WAjn 1 Nu I UN . DC .

DIETHYLENE 6LYCOL MONOBUTYL ETHER 000112-34-5
005482 US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE WASHINGTO? DC EPASw! To52

US EPA. 1992. RfD/RfC WORK GROUP.

DIETHYLENE GLYCOL MONOETHYL ETHER 000111-90-0
005478 SMYTH HF. CP CARPENTER AND CB SHAFFER. 1964. A 2-YEAR STUDY OF DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS FOOD COSMET TOXICOL 2-
641-642.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAI
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONS^WASHINGm DC EP^!/! 86 052

005476 HALL DE. FS LEE. P AUSTIN AND FA FAIRWEATHER. 1966. SHORT-TERM FEEDING STUDY WITH DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS FOOD COSMET
IOXICOL. 4: 263.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC ! EPA MO/lToK

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DIETHYLFORHAMIDE 000617-84-5
010437 ARGUS MF. JC ARCOS AND C HOCH-LIGETI. 1965. THE CARCINOGENIC ACTIVITY OF PROTEIN-DENATURING AGENTS: HEPATOCARCINOGENICITY OF DIOXANE. J.
NATL CANCER INST. 35: 949-958.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIETHYLFORMAMIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DIETHYLHYDRAZINE. 1.2- 001615-80-1
005921 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2-DIETHYLHYDRAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DIMETHOATE 000060-51-5
005923 AMERICAN CYANAMID COMPANY. 1986. MRID NO 00164177 AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHOATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

DIMETHYLANILINE. N.N- 000121-69-7
005924 ABOO K. M WOLFE AND R HILES. 1984. SUBCHRONIC TOXICITY OF N.N-DIMETHYLANILINE TO F-344 RATS AND B6C3F1 MICE. FED PROC 43(3). 1698

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DIMETHYLFORMAMIOE. N.N- 000068-12-2
005925 BECCI. PJ. KA VOSS. WD JOHNSON. ET AL. 1983. SUBCHRONIC FEEDING STUDY OF N.N-DIMETHYLFORMAMIDE IN RATS AND MICE. J AM COLL TOXICOL. 2(6):
371-378.

US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLFORMAMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH, FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

010352 CIRLA. AM. G PISATI. E INVERNIZZI ET AL. 1984. EPIDEMIOLOGICAL STUDY ON WORKERS EXPOSED TO LOW DIMETHYLFORMAMIDE CONCENTRATIONS. G ITAL
MED LAV. 6: 149-156.

CATENACCI. G. D GRAMPELLA. R TERZI. ET AL 1984. HEPATIC FUNCTION IN SUBJECTS EXPOSED TO ENVIRONMENTAL CONCENTRATIONS OF DMF LOWER THAN
THE ACTUALLY PROPOSED TLV. G ITAL MED LAV. 6: 157-158.

US EPA. 1990. RfD/RfC WORK GROUP.

DIMETHYLPHENOL. 2.3- 000526-75-0
005926 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DIMETHYLPHENOL. 2.4- 000105-67-9
010266 US EPA. 1989. NINETY-DAY GAVAGE STUDY IN ALBINO MICE USING 2.4-DIMETHYLPHENOL STUDY 410-2831. PREPARED BY DYNAMAC CORPORATION.
ROCKVILLE. MD. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH, FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.

DIMETHYLPHENOL. 2.5- 000095-87-4
005928 US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN 1C ITY) May 1995

DIMETHYLPHENOL. 2,6- 000576-26-1
005431 VELDRE IA AND HJ JANES. 1979. TOXICOLOGICAL STUDIES OF SHALE OILS. SOME OF THEIR COMPONENTS AND COMMERCIAL PRODUCTS ENVIRON HEALTH
PERSPECT. 30: 141-146.

"?*!!*; 1987' HEALTH EFFECTS ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

DIMETHYLPHENOL. 3.4- 000095-65-8
005437 VELDRE IA AND HJ JANES. 1979. TOXICOLOGICAL STUDIES OF SHALE OILS. SOME OF THEIR COMPONENTS AND COMMERCIAL PRODUCTS ENVIRON HEALTH
PERSPECT. 30: 141-146.
™™.n. EFFECTS ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

US EPA. 1986. RfD/RfC WORK GROUP.

DIMETHYLPHTHALATE 000131-11-3
010267 US EPA. 1994. RfD/RfC WORK GROUP.

010894 US EPA. 1990. RfD/RfC WORK GROUP.

DIMETHYLTEREPHTHALATE 000120-61-6
005930 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF DIMETHYL TEREPHTHALATE FOR POSSIBLE CARCINOGENIC ITY. DHEW/PUB/NIH 79-1376
NCI-CG-TR121.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYL AND METHYL TEREPHTHALATE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE . WASHINGTON . DC .

DIMETHYLUREA. N.N- 000598-94-7
005931 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLUREA PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

DINITRO-0-CRESOL. 4.6- 000534-52-1
010470 US EPA. 1993. RfD/RfC WORK GROUP.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROCRESOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

DINITRO-P-CRESOL. 2.6- 000609-93-8
005934 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.6-DINITRO-P-CRESOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DINITROBENZENE. 1.2- 000528-29-0
010201 CODY TE. S WITHERUP. L HASTINGS. K STEMMER AND RT CHRISTIAN. 1981. 1.3-DINITROBENZENE: TOXIC EFFECT IN VIVO AND IN VITRO J TOXICOL
ENVIRON HEALTH. 7(5): 829-847.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROBENZENES (0-. M-. P-). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

DINITROBENZENE. 1.3- 000099-65-0
010471 CODY TE. S WITHERUP. L HASTINGS. K STEMMER AND RT CHRISTIAN. 1981 1.3-DINITROBENZENE TOXIC EFFECT IN VIVO AND IN VITRO. J TOXICOL
ENVIRON HEALTH. 7(5): 829-847.

US EPA. RfD/RfC WORK GROUP.

DINITROBENZENE. 1.4- 000100-25-4
010202 CODY TE. S WITHERUP. L HASTINGS. K STEMMER AND RT CHRISTIAN. 1981. 1.3-DINITROBENZENE: TOXIC EFFECT IN VIVO AND IN VITRO. J TOXICOL
ENVIRON HEALTH. 7(5): 829-847.

DINITROPHENOL. 2.3- 000066-56-8
005936 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

DINITROPHENOL. 2.4- 000051-28-5
010438 HORNER WD. 1942. DINITROPHENOL AND ITS RELATION TO FORMATION OF CATARACTS. ARCH OPHTHALMOL. 27: 1097-1121.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.

US EPA. 1991. RfD/RfC WORK GROUP.

010895 US EPA. 1991. RfD/RfC WORK GROUP.

DINITROPHENOL. 2.5- 000329-71-5
005937 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DINITROPHENOL. 2.6- 000573-56-8
005938 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

DINITROPHENOL. 3.5- 000586-11-8
005939 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DINITROTOLUENE. 2.3- 000602-01-7
005940 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DINITROTOLUENE. 2.4 000121-14-2
005941 ELLIS HV. CB HONG. CC LEE. ET AL. 1985. SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF 2.4-DINITROTOLUENE. PART I. BEAGLE DOGS J AM COLLEGE
TOXICOL. 4(4): 233-242.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1991. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

DINITROTOLUENE. 2.4- 000121-14-2
010896 US EPA. 1990. RfC WORK GROUP.

DINITROTOLUENE. 2.5- 000619-15-8
005942 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DINITROTOLUENE. 2.6- 000606-20-2
005943 LEE C-C ET AL. 1976. MAMMALIAN TOXICITY OF MUNITIONS COMPOUNDS. PHASE II: EFFECTS OF MULTIPLE DOSES. PART III: 2.6-DITINROTOLUENE. US
ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND. FORT DETRICK. MD.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1991. RfD/RfC WORK GROUP.

DINITROTOLUENE. 3.4- 000610-39-9
005944 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DINOSEB 000088-85-7
005945 DOW CHEMICAL COMPANY. 1981. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY MRID NO 00152675. AVAILABLE FROM EPA. WRITE TO FOI.
EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINOSEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

US EPA. 1986. RfD/RfC WORK GROUP.

DIPHENYLAMINE. N.N- 000122-39-4
005946 THOMAS JO. WE RIBELIN. JR WOODWARD AND F DEEDS. 1967. THE CHRONIC TOXICITY OF DIPHENYLAMINE FOR DOGS TOXICOL APPL PHARMACOL 11.
184-194.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIPHENYLAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

DIRECT LIGHTFAST BLUE 004399-55-7
005947 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT LIGHTFAST BLUE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DISULFOTON 000298-04-4
010412 MOBAY CHEMICAL COMPANY. 1985. MRID NO. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DISULFOTON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON DC.

US EPA. 1986. RfD/RfC WORK GROUP.

ENDOSULFAN 000115-29-7
010926 HOECHST CELANESE CORP. 1989. ENDOSULFAN: 2-YEAR FEEDING/ONCOGENICITY STUDY IN RATS MRID NO. 40256502, 42099502. HED DOC NO. 007937.
AVAILABLE FROM EPA. WRITE TO FOI. EPA, WASHINGTON. DC 20460.

US EPA. 1993. RfD/RfC WORK GROUP.

010938 HOECHST CELANESE CORP. 1989. ENDOSULFAN: 1-YEAR FEEDING STUDY IN DOGS. MRID. NO 41099501 HED NO. 007937. AVAILABLE FROM EPA WRITE TO
FOI. EPA. WASHINGTON, DC 20460.

US EPA. 1993. RfD/RfC WORK GROUP.

ENDOTHALL 000145-73-3
005948 PENNWALT AGCHEM. ND MRID NO 00101735. AVAILABLE FROM US EPA. WRITE TO FOI, EPA. WASHINGTON. DC 20460.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ENDOTHALL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ENDRIN 000072-20-8
005445 VELSICOL CHEMICAL CORPORATION. 1969. MRID NO. 00030198. AVAILABLE FROM EPA. WRITE FOI. EPA, WASHINGTON. DC 20460.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR ENDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ENDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

EPICHLOROHYDRIN 000106-89-8
010440 LASKIN S. AR SELLAKUMAR. M KUSCHNER. ET AL. 1980. INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN NON-INBRED SPRAGUE-DAWLEY RATS. J NATL
CANCER INST. 65(4): 751-757.

US EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC EPA 600/8-83-032F. NTIS PB85-132363.

US EPA. 1991. RfD/RfC WORK GROUP.

010492 QUAST JF. JW HENCK. BJ POSTMA. DJ SCHUETZ AND MJ MCKENNA.1979. EPICHLOROHYDRIN - SUBCHRONIC STUDIES. I. A 90-DAY INHALATION STUDY IN
LABORATORY RODENTS. (FISCHER 344 RATS. SPRAGUE-DAWLEY RATS AND B6C3F1 MICE). DOW CHEMICAL USA. MIDLAND. MI.

US EPA. 1991. RfD/RfC WORK GROUP.

EPTC 000759-94-4
005959 PPG INDUSTRIES. INC. 1986. CONFIDENTIAL BUSINESS INFORMATION: UNPUBLISHED STUDY ACCESSION NO. 263695. 262696. MRID NO. 00161597.
AVAILABLE FROM EPA. WRITE FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPTC. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ETHOPROP 013194-48-4
005951 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHOPROP. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ETHOXYETHANOL ACETATE. 2- 000111-15-9
010507 UNION CARBIDE. 1984. A TERATOGENIC EVALUATION OF CELLOSOLVE ACETATE IN FISHER 344 RATS AND NEW ZEALAND WHITE RABBITS FOLLOWING INHALATION
EXPOSURE. BUSHY RUN RESEARCH CENTER. EXPORT. PA. OCTOBER 1984. FYI-AX-1184-0360

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

ETHOXYETHANOL ACRYLATE. 2- 000106-74-1
005953 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ETHOXYETHANOL DODECANOATE. 2- 000106-13-8
005956 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

ETHOXYETHANOL PHOSPHATE. 2- 068554-00-7
005955 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

ETHOXYETHANOL. 2- 000110-80-5
005470 MELNICK RL. 1984. TOXICITIES OF ETHYLENE GLYCOL AND ETHYLENE GLYCOL MONOETHYL ETHER IN FISCHER 344/N RATS AND B6C3F1 MICE. ENVIRON HEALTH
PERSPECT. 57: 147-155.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXY-ETHANOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

005468 STENGER EG. A LISLOTT. D MUELLER ET AL. 1971. TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYL ETHER. ARZNEIM-FORSCH. 21(6): 880-885.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC. EPA 540/1-86-052.

010441 BARBEE SJ. JB TERRILL. DJ DESOUSA AND CC CONAWAY. 1984. SUBCHRONIC INHALATION TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYL ETHER IN THE RAT
AND RABBIT. ENVIRON HEALTH PERSPECT. 57: 157-163.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC. EPA 540/1-86-052.

US EPA. 1990. RfD/RfC WORK GROUP.

ETHOXYETHYL METHACRYLATE. 2- 002370-63-0
005954 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ETHYL ACETATE 000141-78-6
005957 US EPA. 1986. RAT ORAL SUBCHRONIC STUDY WITH ETHYL ACETATE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

ETHYL BENZENE 000100-41-4
010867 WOLF MA. VK ROWE. DO MCCOLLISTER. RL HOLLINGSWORTH AND F OYEN. 1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND BENZENES. AMA
ARCH IND HEALTH. 14: 387-398. CITED IN US EPA. 1985.

US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR ETHYLBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYLBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

010866 ANDREW FD. RL BUSHCOHBOM. WC CANNON. ET AL. 1981. TERATOLOGIC ASSESSMENT OF ETHYLBENZENE AND 2-ETHOXYETHANOL. BATTELLE PACIFIC NORTHWEST
LABORATORY. RICHLAND. WA. NTIS PB83-208074. P 108.

HARDIN BD. GP BOND. MR SIKOV. ET AL. 1981. TESTING OF SELECTED WORKPLACE CHEMICALS FOR TERATOGENIC POTENTIAL. SCANDJ WORK ENVIRON HEALTH.
7: 66-75.

US EPA. 1990. RfD/RfC WORK GROUP.

ETHYL CHLORIDE 000075-00-3
010371 SCORTICHINI BH. KA JOHNSON. JJ MOMANY-PFRUENDER ET AL 1986. ETHYL CHLORIDE: INHALATION TERATOLOGY STUDY IN CF-1 MICE. DOW CHEMICAL CO.
EPA 86-870002248.

US EPA. 1990. RfD/RfC WORK GROUP.

ETHYL ETHER 000060-29-7
010396 AMERICAN BIOGENICS CORP. 1986. 90-DAY GAVAGE STUDY IN RATS USING ETHYL ETHER STATUS REPORT FOR ABC STUDY NO. 410-23433/18/86.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYL ETHER. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. OFFICE OF SOLID
WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

ETHYL METHACRYLATE 000097-63-2
005961 BORZELLECA JF. PS LARSON. GR HENNIGAR. ET AL. 1964. STUDIES ON THE CHRONIC ORAL TOXICITY OF MONOMERIC ETHYL ACRYLATE AND METHYL
METHACRYLATE. TOXICOL APPL PHARMACOL. 6: 29-36.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL METHACRYLATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

ETHYL-0-XYLENE. 4- 000934-80-5
010472 US EPA. 1984. HEALTH AND ENVIRONMENTAL PROFILE FOR METHYLETHYL BENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC.

ETHYLANILINE. N- 000103-69-5
005958 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N-ETHYLANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ETHYLENE CYANOHYDRIN 000109-78-4
005780 SAUERHOFF MW. WH BRAUN. JC RAMSEY ET AL. 1976. TOXICOLOGICAL EVALUATION AND PHARMACOKINETIC PROFILE OF B-HYDROXYPROPIONITRILE IN RATS J
TOXICOL. ENVIRON. HEALTH. 2(1): 31-44.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ETHYLENE DIAMINE 000107-15-3
005796 YANG RS. RH GARMAN. RR MARONPOT. ET AL. 1983. ACUTE AND SUBCHRONIC TOXICITY OF ETHYLENEDIAMINE IN LABORATORY ANIMALS APPL TOXICOL 3(6)-
512-520.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ETHYLENEDIAMINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

010898 US EPA. 1990. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENIC ITY) "*y 1995
LR. RH GARMAN. MD WOOOSIDE ET AL. 1986. craiciTY AND ONCOGENICITY STUDIES OF ETHYLENE GLYCOL IN RATS AND MICE. FUND APPL

TOXICOL. 7: 547-565.

US EPA. 1987. RfD/RfC WORK GROUP.

005452 MARONPOT RR. JP ZELENAK. EV WEAVER AND NJ SMITH 1983. TERATCGENICITY STUDY OF ETHYLENE GLYCOL IN RATS. DRUG CHEM TOXICOL. 6(6): 579-594.

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR ETHYLENE GLYCOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
SlTERiA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
. RR MAROMPOT. ET AL. ^EDL MONOBUTYL ETHER. ACUTE. 9-DAY AND 90-DAY VAPOR INHALATION STUDIES IN
FISCHER 344 RATS. TOXICOL APPL PHARMACOL. 68: 405-414.

US EPA. 1991. RfD/RfC WORK GROUP.

CTTJVI cur TUTDIIPPA 000096-45-7
010397 GRAHAM SL. KJ DAVIS. WH HANSEN AND CH GRAHAM. 1975. EFFECTS OF PROLONGED ETHYLENE THIOUREA INGESTION ON THE THYROID OF THE RAT. FOOD
COSMET TOXICOL. 13: 493-499.

US EPA. 1991. RfD/RfC WORK GROUP.

010899 US EPA. 1992. RfD/RfC WORK GROUP.

ETTLJVI rni iirur M 000620-14-4
ETHYLTOLUtNt. M- ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ETHYL BENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
A^SEsSMEN? EN!SENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CTUVI rni IICWF n 000611-14-3
ETHYLTOLUtNt. U- ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ETHYL BENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
JLS^BWwSfZ ™A AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.

WASHINGTON. DC.

CTUVI TOI i IPMP P 000622-96-8
005964 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ETHYL BENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

FLUORANTHENE 000206-44-0
010168 US EPA. 1988. 13-WEEK MOUSE ORAL SUBCHRONIC TOXICITY STUDY. PREPARED BY TOXICITY RESEARCH LABORATORIES. LTD MUSKEGON MI FOR THE OFFICE
OF SOLID WASTE, WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

010967 US EPA. 1994. RfD/RfC WORK GROUP.

FLUORENE 000086-73-7
010169 US EPA. 1989. MOUSE ORAL SUBCHRONIC STUDY. PREPARED BY TOXICITY RESEARCH LABORATORIES. LTD. MUSKEGON MI FOR THE OFFICE OF SOLID WASTE
WASHINGTON. DC.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR FLUORENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

FLUORINE / (SOLUBLE FLUORIDE) 007782-41-4
005965 HODGE HC. 1950. THE CONCENTRATION OF FLUORIDES IN DRINKING WATER TO GIVE THE POINT OF MINIMUM CARIES WITH MAXIMUM SAFETY J AM DENT
ASSOC. 40: 436.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR FLUORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

FLURIDONE 059756-60-4
005966 ELANCO PRODUCTS COMPANY. DIVISION OF ELI LILLY AND COMPANY. 1980. CONFIDENTIAL BUSINESS INFORMATION UNPUBLISHED STUDY ACCESSION NOS
070933. 070939. MRID NO. 00103251. 00103305. AVAILABLE FROM EPA. WRITE TO FOI. EPA, WASHINGTON. DC 20460.

US EPA-. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FLURIDONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE AND EMERGENCY RESPONSE.
WASHINGTON, DC.

US EPA. 1988. RfD/RfC WORK GROUP.
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(OTHER THAN CARCINOGEN 1C ITY) May 1995
FOLPET 000133-07-3
005967 ™™ " UN™LISHEO STUOY ACCESSIOI<
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FOLPET. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID
US EPA. 1987. RFD/RFC WORK GROUP.

FORMALDEHYDE 000050-00-0
010398 TIL HP. RA WOUTERSEN. VJ FERON ET AL 1989. TWO-YEAR DRINKING WATER STUDY OF FORMALDEHYDE IN RATS. FOOD CHEM TOXICOL. 27. 77-87.

US EPA. 1989. DRAFT DRINKING WATER HEALTH ADVISORY FOR FORMALDEHYDE. OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.

FORMALDEHYDE CYANOHYDRIN 000107-16-4

005782 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAI
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID
FORMIC ACID 000064-18-6
010268 MALORNY G. 1969. ACUTE AND CHRONIC TOXICITY OF FORMIC ACID AND FORMATE. Z ERNACHRUNGSWISS. 9: 332-339.

US EPA. 1990. RfD/RfC WORK GROUP.

FURAN 000110-00-9

005462 SSS ™ 'ICI" Kmi " fam (C5K02) '" ra MICE
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR FURAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTS ASSFSSMFNT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AN[ ) EMCY SS JisS DC.

US EPA. 1986. RfD/RfC WORK GROUP.

FURFURAL 000098-01-1
005466 SRI (SOUTHERN RESEARCH INSTITUTE). 1981. 90 DAY RAT REPORT. UNPUBLISHED STUDY PERFORMED FOR NTP

US EPA. 1987. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

6LYCIDALDEHYDE 000765-34-4
005968 MINE CH. RJ GUZMAN. MK DUNLAP. R LIMA AND GS LOQUVAM. 1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH ENVIRON HEALTH. 2: 23-30.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

HEPTACHLOR 000076-44-8
005506 VELSICOL CHEMICAL CORP. 1955. MRID NO 00062599. AVAILABLE FROM EPA. WRITE TO FOI, EPA. WASHINGTON, DC 20460.

US EPA. 1987. RfD/RfC WORK GROUP.

HEPTACHLOR EPOXIDE 001024-57-3
010399 DOW CHEMICAL CO. 1958. MRID NO 00061912. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460

US EPA. 1986. RfD/RfC WORK GROUP.

HEPTANE. N- 000142-82-5
005969 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N HEPTANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC. '

HEXABROMOBENZENE 000087-82-1
005970 MENDOZA CE. HM VIJAY. JB SHIELDS AND GW LAVER 1977. EFFECTS OF HEXABROMOBENZENE ON THE MALE RAT. TOXICOL APPL PHARMACOL 41. 127-130.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

HEXACHLOROBENZENE 000118-74- 1
010868 ARNOLD *-*™» ET *• ™- LONG-TERM TOXICITY OF HEXACHLOROBENZENE IN THE RAT AND THE EFFECT OF DIETARY VITAMIN
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROBENZENE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON DC ASSESSMENT OFFICE.

US EPA. 1988. RfD/RfC WORK GROUP.

010900 US EPA. 1990. RfD/RfC WORK GROUP.

HEXACHLOROBUTADIENE 000087-68-3
010927 NTP (NATIONAL TOXICOLOGY PROGRAM). 1991. NTP REPORT ON THE TOXICITY STUDIES OF HEXACHLORO-1.3-BUTADIENE IN B6C3F1 MICE (FEED STUDIES).
(HCBD) IN B6C3F1 MICE BY DIETARY

STUDY WI™ HEXACHLOROBUTADIENE IN RATS. AM IND HYG
US EPA. 1993. RfD/RfC WORK GROUP.
HEXACHLOROCYCLOHEXANE. DELTA- 000319-86-8
010495 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMFNTAI
VIRONMENTAL CRITERIA AN° ASSESSMENT °FFICE' CINCINNATI' OH ™ THE OFFICE OF ^
HEXACHLOROCYCLOHEXANE. EPSILON- 006108-10-7
010496 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMFNTAI
' ECNVIR°NMENTAL CRITERIA MD ASSESSMENT OFFICE' CINCINNATI. OH ™ THE OFFICE OF ^
HEXACHLOROCYCLOHEXANE. GAMMA- 000058-89-9
005537 ZOECON CORPORATION. 1983. MRID NO 00128356. AVAILABLE FROM EPA WRITE TO FOI . EPA. WASHINGTON. DC 20460.
US EPA. 1986. RfD/RfC WORK GROUP.

010903 US EPA. 1992. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) Hay 1995

HEXACHLOROCYCLOPENTADIENE 000077-47-4
005299 AflDO. KM. CA MONTGOMERY. MM KLUWE ET AL. 1984 TOXICITY OF HEXACHLOROCYCLOPENTADIENE: SUBCHRONIC (13-WEEK) ADMINISTRATION BY GAVAGE TO
F344 RATS AND B6C3F1 MICE. J APPL TOXICOL. 4: 75-81.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROCYCLOPENTANE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

010445 ABDO. KM. CA MONTGOMERY. J ROYCROFT. HA RAGAN. RA RENNE. WE GIDDINS. 1986 SUBCHRONIC (13-WEEK) OINHALATION TOXCICITY OF
HEXACHLOROCYCLOPENTADIENE (HCCPD) IN F344 RATS AND B6C3F1 MICE. ABSTRACT SUBMITTED TO THE SOCIETY OF TOXICOLOGY FROM THE 1986 MEETING.

BATTELLE NORTHWEST LABORATORIES. 1984. INHALATION CARCINOGENESIS BIOASSAY STUDY. SUBCHRONIC STUDY REPORT ON HEXACHLOROCYCLOPENTADIENE IN
RATS. SUBMITTED TO THE NATIONAL TOXICOLOGY PROGRAM.

US EPA. 1988. HEALTH AND DNVIRONMENTAL EFFECTS DOCUMENT FOR HEXACHLOROCYCLOPENTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROCYCLOPENTADIENE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

HEXACHLOROETHANE 000067-72-1
005518 GOR2INSKI. SJ. RJ NOLAN. SB MCCOLLISTER. ET AL. 1985. SUBCHRONIC ORAL TOXICITY. TISSUE DISTRIBUTION AND CLEARANCE OF HEXACHLOROETHANE IN
THE RAT. DRUG CHEM TOXICOL. 8(3): 155-169.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HEXACHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

010904 US EPA. 1992. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

HEXACHLOROPHENE 000070-30-4
005972 NATIONWIDE CHEMICAL CORPORATION. 1974. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 00055365. AVAILABLE FROM EPA. WRITE
TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROPHENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

HEXAMETHYLENE DIAMINE 000124-09-4
005973 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXAMETHYLENEDIAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

HEXANE. N- 000110-54-3
005974 KRASAVAGE WJ. JL O'DONOGHUE. GD DIVINCENZO AND TERHAAR. 1980. RELATIVE NEUROTOXICITY OF METHYL-N-BUTYL KETONE. N-HEXANE AND THEIR
METABOLITES. TOXICOL APPL PHARMACOL. 52(3): 433-441.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N-HEXANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

010273 SANAGI S. Y SEKI. K SUGIMOTO AND M HIRATA. 1980. PERIPHERAL NERVOUS SYSTEM FUNCTIONS OF WORKERS EXPOSED TO N-HEXANE AT A LOW LEVEL. INT
ARCH OCCUP ENVIRON HEALTH. 47: 69-79.

HEXANONE. 2- 000591-78-6
005976 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N-HEXANONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

HYDROGEN SULFIDE 007783-06-4
010269 WATTERAU H. W OECKERT AND UG KNAPE. 1964. TESTS FOR THE APPLICATION OF DRIED GREEN FODDER WITH HIGH H2S CONTENT (EXPERIMENTS WITH POULTRY
AND FATTENED PIGS). LETTIN FEEDS TESTING CENTER AND FEEDING HALL. FEEDS SCIENCE. FETTERUNG 5: 383-393.

US EPA. 1985. RfD/RfC WORK GROUP.

010354 CUT. 1983. 90 DAY VAPOR INHALATION TOXICITY STUDY OF HYDROGEN SULFIDE IN B6C3F1 MICE. EPA OTS PUBLIC FILES FICHE N00000255-0 DOCUMENT
NO FYI-OTS-0883-0255.

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HYDROGEN SULFIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WAoHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.

HYDROQUINONE 000123-31-9
005526 CARLSON. AJ AND NR BREWER. 1953. TOXICITY STUDIES ON HYDROQUINONE PROC SOC EXP BIOL MED. 84: 684-688

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HYDROQUINONE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

010905 US EPA. 1990. RfD/RfC WORK GROUP.

IRON 007439-89-6
005527 US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR IRON. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. OFFICE OF EMERGENCY AND
KtMtDIAL RESPONSE. WASHINGTON, DC.

ISOBUTYL ALCOHOL 000078-83-1
005977 US EPA. 1986. RAT ORAL SUBCHRONIC TOXICITY WITH ISOBUTYL ALCOHOL. OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOBUTANOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ISOPHORONE 000078-59-1
005910 NOR-AM AGRICULTURAL PRODUCTS. INC. 1972. MRID NO 00123976. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF ISOPHORONE (CAS NO 78-59-1) IN F344/N RATS AND B6C3F1
MICE (GAVAGE STUDIES). NTP TECH REPORT SER NO 291. NIH PUBL NO 86-2547.

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR ISOPHORONE. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

010906 US EPA. 1990. RfD/RfC WORK GROUP.

ISOPROPALIN 033820-53-0
005978 ELI LILY CO. 1985. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOPROPALIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

LACTONITRILE 000078-97-7
005783 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

LEAD 007439-92-1
010447 REFER TO IRIS.

LEAD ALKYLS
010448 REFER TO IRIS.

LINURON 000330-55-2
005990 DU PONT DE NEMOURS AND COMPANY. INC. 1962. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO 00018374. AVAILABLE FROM EPA.
WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR LINURON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

MALATHION 000121-75-5
005991 MOELLER HC AND JA RIDER. 1962. PLASMA AND RED BLOOD CELL-CHOLINESTERASE ACTIVITY AS INDICATIONS OF THE THRESHOLD OF INCIPIENT TOXICITY OF
ETHYL-P-NITROPHENOL THIONEBENZENEPHOSPHORATE (EPN) AND MALATHION IN HUMAN BEINGS. TOXICOL APPL PHARMACOL. 4: 123-130.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALATHION. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

NALEIC ANHYDRIDE 000108-31-6
005992 JESSUP DC. D ALDRIDGE. JL SCHARDEIN AND M BLAIR. 1982. THREE-GENERATION REPRODUCTION STUDY IN RATS (MODIFIED TO A2-GENERATION STUDY).
MALEIC ANHYDRIDE IR-79-358. INTERNATIONAL RESEARCH AND DEVELOPMENT CORP. FOR MONSANTO CO.. ST. LOUIS.MO UNPUBLISHED 8D SUBMISSION.
MICROFICHE NO OTS 0206655. DOCUMENT ID 878214777

PREACHE M. 1983. CHRONIC DIETARY ADMINISTRATION OF MALEIC ANHYDRIDE. VOL. 1 NARRATIVE. FYI-OTS SUBMISSION 1283-0277. PREPARED BY ITT
RESEARCH INSTITUTE FOR CHEMICAL INDUSTRY INSTITUTE OF TECHNOLOGY. RESEARCH TRIANGLE PARK. NC.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALEIC ANHYDRIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

MALEIC HYDRAZIDE 000123-33-1
005993 UNIROYAL CHEMICAL CO. 1981. ACCESSION NO. 250523.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MALEIC ANHYDRIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

MALONONITRILE 000109-77-3
005994 PANOV I. M ZLATEVA AND G ANTOV. 1972. TOXICOLOGICAL CHARACTERISTICS OF DICYANOMETHANE. CHRONIC EFFECTS IN WHITE RATS KHIG
ZDRAVEOPAZVANE. 15(6): 553-562.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALONONITRILE, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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(OTHER THAN CARCINOGENICITY) May 1995

HANCOZEB 008018-01-7
005995 US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MANCOZEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

MANEB 012427-38-2
005996 MANEB DATA TASK FORCE. 1986. MRID NO 00161552. (CITED IN US EPA 1987.) AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

ROHM AND HAAS CO. 1977. MRID NO 00129980. (CITED IN US EPA 1987.) AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MANEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

MANGANESE 007439-96-5
010850 KONDAKIS XG. N MAKRIS. M LEOTSINIDIS. M PRINOU AND T PAPAPETROPOULOS 1989 POSSIBLE HEALTH EFFECTS OF HIGH MANGANESE CONCENTRATION IN
DRINKING WATER. ARCH ENVIRON HEALTH. 44: 175-178.

US EPA 1993. DRINKING WATER CRITERIA DOCUMENT FOR MANGANESE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

US EPA. 1992. RfD/RfC WORK GROUP.

010851 WHO (WORLD HEALTH ORGANIZATION). 1973. TRACE ELEMENTS IN HUMAN NUTRITION: MANGANESE. REPORT OF A WHO EXPERT COMMITTEE TECHNICAL REPORT
SERVICE. 532. WHO. GENEVA. SWITZERLAND. PP 34-36.

SCHROEDER HA. JJ BALASSA. IH TIPTON. 1966. ESSENTIAL TRACE METALS IN MAN: MANGANESE. A STUDY IN HOMEOSTASIS. J CHRON DIS 19. 545-571.

NRC (NATIONAL RESEARCH COUNCIL). 1989. RECOMMENDED DIETARY ALLOWANCES. 10TH ED. FOOD AND NUTRITION BOARD. NATIONAL RESEARCH COUNCIL.
NATIONAL ACADEMY PRESS. WASHINGTON. DC. PP 230-235.

US EPA. 1993. DRINKING WATER CRITERIA DOCUMENT FOR MANGANESE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

US EPA. 1992. RfD/RfC WORK GROUP.

010959 ROELS HA. P GHYSELEN. JP BUCHET. E CEULEMANS. RR LAUWERYS. 1992. ASSESSMENT OF THE PERMISSIBLE EXPOSURE LEVEL TO MANGANESE IN WORKERS
EXPOSED TO MANGANESE DIOXIDE DUST. BR J IND MED. 49: 25-34.

ROELS H. R LAUWERYS. JP BUCHET ET AL. 1987. EPIDEMIOLOGICAL SURVEY AMONG WORKERS EXPOSED TO MANGANESE: EFFECTS ON LUNG, CENTRAL NERVOUS
SYSTEM.'AND SOME BIOLOGICAL INDICES. AM j IND MED. ii: 307-327.

US EPA. 1993. RfD/RfC WORK GROUP.

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(OTHER THAN CARCINOGENICITY) May 1995

MEPHOSFOLAN 000950-10-7
005997 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MEPHOSFOLAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

MERCURIC CHLORIDE 007487-94-7
005800 ANDRES. P. 1984. IGA-AGG DISEASE IN THE INTESTINE OF BROWN-NORWAY RATS INGESTING MERCURIC CHLORIDE CLIN IMMUNOL IMMUNOPATHOL. 20:
488-494.

BERNAUDIN. JF. E DRUET. P DRUET. R MASSE. 1981. INHALATION OR INGESTION OF ORGANIC OR INORGANIC MERCURIALS PRODUCES AUTO-IMMUNE DISEASE
IN RATS. CLIN IMMUNOL IMMUNOPATHOL. 20: 129-135.

DRUET. P. E DRUET. F POTDEVIN, C SAPIN. 1978. IMMUNE TYPE GLOMERULONEPHRITIS INDUCED BY HG CL2 IN THE BROWN NORWAY RAT. ANN IMMUNOL.
129C: 777-792.

US EPA. 1987. PEER REVIEW WORKSHOP ON MERCURY ISSUES. OCTOBER 26-27. 1987. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH.

US EPA. 1988. RfD/RfC WORK GROUP.

U.S.' EPA. 1995. MERCURY STUDY REPORT TO CONGRESS. OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON. DC. EXTERNAL REVIEW DRAFT.
EPA/600/P-94/002Ab.

MERCURY ELEMENTAL 007439-97-6
010270 FAWER RF. V DERIBAUPIERRE. MP GUILLEMIN ET AL. 1983. MEASUREMENT OF HAND TREMOR INDUCED BY INDUSTRIAL EXPOSURE TO METALLIC MERCURY. J IND
MED. 40: 204-208.

PIIKIVI L. 1989. CARDIOVASCULAR REFLEXES AND LONG-TERM EXPOSURE TO MERCURY VAPOR INT ARCH OCCUP ENVIRON HEALTH. 61: 391-395.

PIIKIVI L AND H HANNINEN. 1989. SUBJECTIVE SYMPTOMS AND PSYCHOLOGICAL PERFORMANCE OF CHLORINE-ALKALI WORKERS. SCANDJ WORK ENVIRON HEALTH.
15: 69-74.

PIIKIVI L AND V TOLONEN. 1989. EEG FINDINGS IN CHLOR-ALKALI WORKERS SUBJECTED TO LONG-TERM EXPOSURE TO MERCURY VAPOR BR J IND MED 46-
370-375.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR MERCURY. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.
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(OTHER THAN CARCINOGENICITY) Hay 1995

MERPHOS 000150-50-5
005998 ABOU-DONIA MB DG GRAHAM PR TIMMONS AND BL REICHERT. 1980. LATE ACUTE. DELAYED NEUROTOXIC AND CHOLINERGIC EFFECTS OF
S.S.S-TRIBUTYLPHOSPHOROTRITHIOITE (MERPHOS) IN HENS. TOXICOL APPL PHARMACOL 53 439-457.

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MERPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

010907 US EPA. 1992. RfD/RfC WORK GROUP.

MERPHOS OXIDE 000078-48-8
005999 ABOU-DONIA MB DG GRAHAM KM ABDO AND AA KOMEIL. 1979. DELAYED NEUROTOXIC. LATE ACUTE AND CHOLINERGIC EFFECTS OF
sTs-TRIBUTYLPHOSPHOROTRITHIOATE (DEF): SUBCHRONIC (90 DAYS) ADMINISTRATION IN HENS TOXICOLOGY. 14: 229-243.

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MERPHOS OXIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

010908 US EPA. 1992. RfD/RfC WORK GROUP.

MFTHAPRYIONTTRILE 000126-98-7
005812 POZZANI. DC. CR KINKEAD AND JM KING. 1968. THE MAMMALIAN TOXICITY OF METHACRYLONITRILE. AM IND HYG ASSOC J. 29(3): 202-210

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT ENvSMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.

US EPA. 1987. RfD/RfC WORK GROUP.

METHANOL 000067-56-1
010271 US EPA. 1986. RAT ORAL SUBCHRONIC TOXICITY STUDY WITH METHANOL. OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

METHOMYL 016752-77-5
005802 E.I. DU PONT OE NEMOURS AND COMPANY. INC. 1968. MRID 0007091. 00009012 AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHOMYL. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH.

US EPA. 1986. RFD/RFC WORK GROUP.

METHOXYCHLOR 000072-43-5
010357 KINCAID ENTERPRISES. INC. 1989. MRID NO 0015992. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1990. RfD/RfC WORK GROUP.

010909 US EPA. 1991. RfD/RfC WORK GROUP.

METHOXYETHANOL ACETATE. 2- 000110-49-6
010497 MILLER RR. LL CALHOUN AND BL YANO. 1982. ETHYLENE GLYCOL MONOMETHYL ETHER. 13-WEEK VAPOR INHALATION STUDY IN MALE RABBITS REPORT
PREPARED FOR THE CHEMICAL MANUFACTURERS ASSOCIATION. MARCH 25. 1982.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXYETHANOL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

METHOXYETHANOL. 2- 000109-86-4
010372 MILLER RR. JA AYRES. JL YOUNG ET AL. 1983. ETHYLENE GLYCOL MONOMETHYL ETHER I SUBCHRONIC VAPOR INHALATION STUDY WITH RATS AND RABBITS.
FUND APPL TOXICOL. 3(1): 49-54.

US EPA. 1990. RfD/RfC WORK GROUP.

METHYL ACETATE 000079-20-9
010002 TOXICITY RESEARCH LABORATORY. 1986. RAT ORAL SUBCHRONIC TOXICITY STUDY WITH METHANOL SPONSORED BY OFFICE OF SOLID WASTE. US EPA.
WASHINGTON. DC.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

METHYL ACRYLATE 000096-33-3
010498 KLIMISCH HJ AND W REININGHAUS. 1984. CARCINOGENICITY OF ACRYLATES: LONG-TERM INHALATION STUDIES ON METHYL ACRYLATE (MA) AND N-BUTYL
ACRYLATE (BA) IN RATS. TOXICOLOGIST. 4(1): 53.

METHYL ETHYL KETONE 000078-93-3
010853 COX, GE. 1975. TOXICITY STUDIES IN RATS WITH 2-BUTANOL: INCLUDING GROWTH. REPRODUCTION. AND TERATOGENIC OBSERVATIONS FOOD AND DRUG
RESEARCH LABORATORIES. INC. (91MR R 1673)

US EPA. 1992. RfD/RfC WORK GROUP.

010845 SCHWETZ BA. TJ MAST. RJ WEIGEL. ET AL. 1991. DEVELOPMENTAL TOXICITY OF INHALED METHYL ETHYL KETONE IN MICE. FUND APPL TOXICOL. 16:
742-748.

MAST. TJ. JA DILL. JJ EVANOFF. ET AL. 1989. INHALATION DEVELOPMENTAL TOXICOLOGY STUDIES: TERATOLOGY STUDY OF METHYLETHYL KETONE IN MICE.
FINAL REPORT. PREPARED BY PACIFIC NORTHWEST LABORATORY, BATELLE MEMORIAL INSTITUTE. FOR THE NATIONAL TOXICOLOGY PROGRAM. WASHINGTON. DC.
PNL-6833 UC-408.

US EPA. 1991. RfD/RfC WORK GROUP.

METHYL ETHYL KETONE PEROXIDE 001338-23-4
010948 US EPA. 1993. RfD/RfC WORK GROUP.

METHYL ISOBUTYL KETONE 000108-10-1
010949 MICROBIOLOGICAL ASSOCIATES. 1986. SUBCHRONIC TOXICITY OF METHYL ISOBUTYL KETONE IN SPRAGUE-DAWLEY RATS. PERFORMED FOR RESEARCH TRIANGLE
INSTITUTE. PO BOX 12194. RESEARCH TRIANGLE PARK. NC. 27709. FINAL REPORT STUDY NO 522104

US EPA. 1993. RfD/RfC WORK GROUP.

METHYL ISOCYANATE 000624-83-9
010013 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ISOCYANATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

METHYLMERCURY 022967-92-6
010970 MARSH. O.O.. T.W. CLARKSON. C. COX ET AL. 1987. FETAL METHYLMERCURY POISONING: RELATIONSHIP BETWEEN CONCENTRATION IN SINGLE STRANDS OF
MATERNAL HAIR AND CHILD EFFECTS. ARCH. NEUROL. 44: 1017-1022.

SEAFOOD SAFETY. 1991. COMMITTEE ON EVALUATION OF THE SAFETY OF FISHERY PRODUCTS. CHAPTER ON METHYLMERCURY: FDA RISK ASSESSMENT AND
CURRENT REGULATIONS. NATIONAL ACADEMY PRESS. WASHINGTON. DC. P. 196-221.

U.S. EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR MERCURY. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATION AND STANDARDS. WASHINGTON. DC.
EPA/440/5-80/058. NTIS PB 81-117699.

U.S. EPA. 1995. MERCURY STUDY REPORT TO CONGRESS. OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON. DC. EXTERNAL REVIEW DRAFT.
EPA/600/P-94/002Ab.

U.S. EPA. 1994. RfD/RfC WORK GROUP.

METHYL METHACRYLATE 000080-62-6
010014 BORZELLECA JF. PS LARSON. GR HENNIGAR. ET AL 1964. STUDIES ON THE CHRONIC ORAL TOXICITY OF MONOMERIC ETHYL ACRYLATE AND METHYL
METHACRYLATE. TOXICOL APPL PHARMACOL. 6: 29-36.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL METHACRYLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

METHYL PARATHION 000298-00-0
010015 MONSANTO CO. 1983. ACCESSION NO 252501-252503. 253346. 253372-253374. MRID NO 000139023. 00143965. 00145507. AVAILABLE FROM EPA WRITE
TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL PARATHION PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

010846 DALY. IW AND WE RINEHART. 1980. A THREE-MONTH FEEDING STUDY OF METHYL PARATHION IN RATS. PROJECT 77-2054 MRID NO. 74299 AVAILABLE FROM
EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYL PARATHION PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Nay 1995

STYRENE (MIXED ISOMERS) 025013-15-4
010500 FINAL CHRONIC REPORT PERFORMED FOR THE NTP UNDER CONTRACT NO N01-ES-38042.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYL STYRENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

METHYL-4-CHLOROPHENOXY) BUTYRIC ACID. 4-(2- 000094-81-5
010008 RHODIA. INC. 1970. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 00116345. AVAILABLE FROM EPA. WRITE TO FOI EPA
WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MCPA AND MCPB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1990. INTEGRATED RISK INFORMATION SYSTEM (IRIS). ONLINE. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI. OH.

•US EPA. 1987. RfD/RfC WORK GROUP.

METHYL-4-CHLOROPHENOXY) PROPIONIC ACID. 2-(2- 000093-65-2
010009 BASF AKTIEGERELLSCHAFT. 1985. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY MRID NO 00158359 AVAILABLE FROM EPA WRITE TO FOI
EPA, WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MCPP. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

METHYL-4-CHLOROPHENOXYACETIC ACID. 2- 000094-74-6
010007 INDUSTRY TASK FORCE ON MCPA RESEARCH DATA. 1986. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 00164352 AVAILABLE FROM
EPA. WRITE TO FOI. EPA. WASHINGTON, DC 20460.

US EPA. 1988. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY)
Hay 1995
METHYLCYCLOHEXANE
010431 KINKEAD ER. CC HAUN MG SCHNEIDER. ET AL.
ANNOUNCEMENTS AND INDEX. ISSUE 21. 29 P.
000108-87-2
1985. CHRONIC INHALATION EXPOSURE OF EXPERIMENTAL ANIMALS TO METHYLCYCLOHEXANE. GOVT REPORTS
US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYLCYCLOHEXANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

METHYLENE BROMIDE 000074-95-3
010501 KEYES DG. JW HENCK. GC JERSEY. RJ KOCIBA. DJ SCHWETZ AND TO LANDRY 1982. METHYLENE BROMIDE: A 90-DAY REPEATED INHALATION TOXICITY STUDY
IN RATS AND DOGS WITH A SUBSEQUENT TWO-YEAR HOLDING PERIOD FOR RATS. TOXICOLOGY RESEARCH LAB. HEALTH AND ENVIRONMENTAL SCIENCES. DOW
CHEMICAL CO.. MIDLAND. MI.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYLENE BROMIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

METHYLENE CHLORIDE / (DICHLOROMETHANE) 000075-09-2
005553 NATIONAL COFFEE ASSOCIATION. 1982. 24-MONTH CHRONIC TOXICITY AND ONCOGENICITY STUDY OF METHYLENE CHLORIDE IN RATS FINAL REPORT. PREPARED
BY HAZLETON LABORATORIES AMERICA. INC.. VIENNA. VA. UNPUBLISHED

US EPA. 1985. DRINKING WATER CRITERIA DOCUMENT FOR METHYLENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.
005552
US EPA. 1985. RfD/RfC WORK GROUP.

NITSCHKE KD. JD BUREK. TJ BELL. RJ KOCIBA. LW RAMPEY AND MJ MCKENNA.
ONCOGENICITY STUDY IN RATS. FUND APPL TOXICOL. 10: 1-12.
1988. METHYLENE CHLORIDE: A 2-YEAR INHALATION TOXICITY AND
US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR METHYLENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
METHYLENE-BIS(2-CHLOROANILINE). 4.41- 000101-14-4
010413 STULA EF. JR BARNES. H SHERMAN. CF REINHARDY AND JA ZAPP.1977.
(MOCA). J ENVIRON PATHOL TOXICOL. 1(1): 31-50.
URINARY BLADDER TUMORS IN DOGS FROM 4.41-METHYLENE-BIS(2-CHLOROANILINE)
US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4.4'-METHYLENE-BIS(2-CHLOROANILINE). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON DC.

010933 US EPA. 1993. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY)
Nay 1995
METHYLENEDIPHENYL ISOCYANATE. 4.4- / (DIPHENYLMETHANE DIISOCYANATE) 000101-68-8
010449 REUZEL PGJ JHG ARTS. MHM KUYPERS. ET AL. 1990. CHRONIC TOXICITY/CARCINOGENICITY INHALATION STUDY OF POLYMERIC METHYLENEDIPHENYL
DIISOCYANATE AEROSOL IN RATS. FINAL REPORT. PREPARED BY CIVO INSTITUTE FOR THE INTERNATIONAL ISOCYAWE INSTITUTE.

REUZEL PGJ. JHG ARTS. LG LOMAX. ET AL. 1998. CHRONIC INHALATION AND CARCINOGENICITY STUDY OF RESP1RABLE POLYMERIC METHYLENE DIPHENYL
DIISOCYANATE (POLYMERIC MOD AEROSOL IN RATS. FUND APPL TOXICOL. 22: 195-210 "J-TntKiL ntmrLtNt UlHHtNYL

US EPA. 1993. RfD/RfC WORK GROUP.

METOLACHLOR 051218-45-2
010950 TISDEL M. T JACKSON. P MACWILLIAMS ET AL. 1983. TWO-YEAR CHRONIC ORAL TOXICITY AND ONCOGENICITY STUDY WITH METOLACHLOR IN ALBINO RATS-
STUDY NO. 80030. FINAL REPORT. (UNPUBLISHED STUDY RECEIVED MAY 24. 1983 UNDER 100-587 PREPARED BY HAZLETON RALTECH INC SUBMITTED BY
cS^f IT" GREENSBOR0' NC: CDL:250369-A. 250370. 250371. 250272. 259373. 259374. 259375.) REFERRED TO AS CIBA-GEIGY 1983 IN U S
EPA (1993). MRID 00129377. AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460.

N°-
REFERRED T0 AS CIBA-GEIGY
1N
EPA (1993) MR1D °0080897-
AUn cuuiDnyycur., ,occccD "T™ °RINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METOLACHLOR. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

METRIBUZIN 021087-64-9
010928 MOBAY CHEMICAL CORPORATION. 1974. MRID 000061260. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1986. RfD/RfC WORK GROUP.

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METRIBUZIN PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL EFFECTS. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON DC

MIREX 002385-85-5
010841 NTP (NATIONAL TOXICOLOGY PROGRAM). 1990. TOXICOLOGY AND CARCINOGENESIS STUDIES OF MIREX (CAS NO 2385-85-5) IN F344/N RATS. (FEED
oIUUltoJ . NIr IK t513.

US EPA. 1992. RFD/RFC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

MOLINATE 002212-67-1
010017 STAUFFER CHEMICAL COMPANY. 1981. MRID NO 00079209. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MOLINATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

MOLYBDENUM 007439-98-7
010489 KOLVAL'SKIY VV GA YAROVAYA AND DM SHMAVONYAN. 1961. CHANGES OF PURINE METABOLISM IN MAN AND ANIMALS UNDER CONDITIONS OF MOLYBDENUM
BIOGEOCHEMICAL PROVINCES. ZH OBSHCH BIOL. 22: 179-191. (IN RUSSIAN. TRANSLATION)

US EPA. 1991. RfD/RfC WORK GROUP.

MONOCHLORAMINE 010599-90-3
010517 NTP (NATIONAL TOXICOLOGY PROGRAM). 1990. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORINATED AND
CHLORAMINATED WATER IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NTP TR 392. NATIONAL INSTITUTES OF HEALTH.

US EPA 1992 DRINKING WATER CRITERIA DOCUMENT FOR CHLORAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE HEALTH AND ECOLOGICAL CRITERIA DIVISION. OFFICE OF SCIENCE AND
TECHNOLOGY. OFFICE OF WATER. WASHINGTON. DC.

US EPA. 1992. RfD/RfC WORK GROUP.

NAPHTHOQUINONE. 1.4- 000130-15-4
010020 US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.4-NAPHTHOQUINONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1991. RfD/RfC WORK GROUP.

NICKEL CYANIDE 000557-19-7
010953 US EPA. 1993. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

NICKEL. SOLUBLE SALTS VARIOUS
005579 AMBROSE. AM. DS LARSON. JR BORZELLECA AND GR HENNIGAR. JR. 1976. LONG-TERM TOXICOLOGIC ASSESSMENT OF NICKEL IN RATS AND DOGS. J GOOD SCI
TECHNOL. 13: 181-187.

US EPA. 1991. DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR NICKEL. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

US EPA. 1991. RfD/RfC WORK GROUP.

NICOTINONITRILE 000100-54-9
005584 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE CINCINNATI
OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

NITRIC OXIDE 010102-43-9
010451 REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

US EPA. 1994. RfD/RfC WORK GROUP.

NITRITE 014797-65-0
010021 WALTON G. 1951. SURVEY OF LITERATURE RELATING TO INFANT METHEMOGLOBINEMIA DUE TO NITRATE-CONTAMINATED WATER AM J PUB HEALTH 41-
986-996.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITRITE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1992. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
May 1995
NITROANILINE. 2-
010936 US EPA.
000088-74-4
1992. RfO/RfC WORK GROUP.
010935 BIO/DYNAMICS 1983. PROJECT NO. (BD-82-270). A FOUR WEEK INHALATION STUDY OF ORTHO-NITROANILINE IN MALE RATS. FINAL REPORT. SUBMITTED TO
OR. .RASHMI NAIR. MONSANTO CO.. AUGUST 16. 1983. EPA 87821478. #OTS0206486 P 1A-17. 32-42. 46-48. 55-58. 62-67.

US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROANILINE (0-. M-. P-). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA 1991 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-NITROANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

NITROANILINE. M- 000099-09-2
010400 US EPA 1991 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 3-NITROANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

NITROANILINE. P- 000100-01-6
010024 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROANILINE (0-. M-. P-) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

NITROBENZENE 000098-95-3
005589 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1984. NINETY-DAY INHALATION STUDY OF NITROBENZENE IN F-344 RATS. CD RATS AND B6C3F1
MICE WITH COVER LETTER DATED 6/24/84 AND EPA RESPONSE DATED 8/06/84. UNPUBLISHED STUDY FYI-OTS-0784-0333 AND COMPUTER PRINT-OUT OF
PATHOLOGY FINDING.

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR NITROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

NITROFURANTOIN 000067-20-9
005593 SRI (SOUTHERN RESEARCH INSTITUTE). 1980. SUBCHRONIC TOXICITY REPORT ON NITROFURANTOIN (C55196) IN FISCHER-344 RATS AND B6C3F1 MICE.
TRACOR JIT CO. INC. ROCKVILLE. MD. CONTRACT NOS N01-CP-43350 AND 78-65-106002 US EPA
s
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITROFURANS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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(OTHER THAN CARCINOGEN1CITY) May 1995

NITROGEN DIOXIDE 010102-44-0
010402 US EPA. 1994. RfD/RfC WORK GROUP.

010912 REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

NITROGEN OXIDES
010170 US EPA. 1982. AIR QUALITY CRITERIA FOR OXIDES OF NITROGEN. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT RESEARCH TRIANGLE PARK NC EPA
600/8-82-026F. NTIS PB83-163337.

NITROMETHANE 000075-52-5
010026 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

NITROPHENOLS
005594 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR NITROPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

NITROPROPANE. 2- 000079-46-9
010374 ANGUS CHEMICAL CO. 1985. FINAL REPORT CHRONIC INHALATION EXPOSURE TO RATS TO VAPORS OF 2-NITROPROPANE AT 100 PPM PREPARED BY COULSTON
INTERNATIONAL CORP FOR ANGUS CHEMICAL CO OTS NO 204292. DOC NO 8EHQ-0985-0170 FICHE NO 0200504.

ANGUS CHEMICAL CO. 1985. CHRONIC INHALATION OF 200 PPM OF2-NITROPROPANE IN RATS PREPARED BY COULSTON INTERNATIONAL CORP (MAY 1978) FOR
ANGUS CHEMICAL CO. OTS NO 204292. DOC NO 8EHQ-0985-0170. FICHE NO 0200504

GRIFFIN TB. F COULSTON AND AA STEIN. 1980. CHRONIC INHALATION EXPOSURE OF RATS TO VAPORS OF 2-NITROPROPANE AT 25 PPM ECOTOXICOL ENVIRON
SAF. 4(3): 267-281.

GRIFFIN TB. AA STEIN. F COULSTON. 1981. HISTOLOGICAL STUDY OF TISSUES AND ORGANS FROM RATS EXPOSED TO VAPORS OF 2-NITROPROPANE AT 25 PPM
ECOTOXOCOL ENVIRON SAF. 5(2): 194-201.

US EPA 1990. RfD/RfC WORK GROUP.

NITROSODIPHENYLAMINE. P- 000156-10-5
010027 US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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(OTHER THAN CARCINOGEN1CITY) May 1995

NITROTOLUENE. M- 000099-08-1
010029 CISS M. N HUYEN. H DUTERTRE. N PHU-LICH AND R TRUHAUT. 1980. TOXICOLOGICAL STUDY OF NITROTOLUENES LONG-TERM TOXICITY DAKAR MEDICAL. 25.
293-302.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROTOLUENES (0-. M-. P-) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

NITROTOLUENE. 0- 000088-72-2
010028 CISS M. N HUYEN. H DUTERTRE. N PHU-LICH AND R TRUHAUT. 1980. TOXICOLOGICAL STUDY OF NITROTOLUENES. LONG-TERM TOXICITY. DAKAR MEDICAL. 25:
293-302.

NITROTOLUENE. P- 000099-99-0
010030 CISS M. N HUYEN. H DUTERTRE. N PHU-LICH AND R TRUHAUT. 1980. TOXICOLOGICAL STUDY OF NITROTOLUENES: LONG-TERM TOXICITY DAKAR MEDICAL. 25:
293-302.

OCTABROMODIPHENYL ETHER 032536-52-0
010032 CARLSON GP. 1980. INDUCTION OF XENOBIOTIC METABOLISM IN RATS BY BROMINATED DIPHENYL ETHERS ADMINISTERED FOR 90 DAYS. TOXICOL LETT 6:
207-212.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC

US EPA. 1986. RfD/RfC WORK GROUP.

OCTAMETHYLPYROPHOSPHORAMIDE 000152-16-9
010031 RIDER JA. HC MOELLER, EJ PULETTI AND JI SWADER. 1969. TOXICITY OF PARATHION. SYSTOX. OCTAMETHYLPYROPHOSPHORAMINE AND METHYL PARATHION IN
MAN. TOXICOL APPL PHARMACOL. 14(3): 603-611.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR OCTAMETHYLPYROPHOSPHORAMIDE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

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(OTHER THAN CARCINOGENICITY) Nay 1995

OSMIUM TETROXIDE 020816-12-0
010954 US EPA. 1993. RfD/RfC WORK GROUP.

OZONE 010028-15-6
010171 US EPA. 1986. AIR QUALITY CRITERIA FOR OZONE AND OTHER PHOTOCHEMICAL OXIDANTS OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT RESEARCH
TRIANGLE PARK. NC. EPA 600/8-84-020F. NTIS PB87-142949.

PARALDEHYDE 000123-63-7
010033 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PARALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

PARATHION 000056-38-2
005598 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR PARATHION. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

PARTICULATE MATTER
010034 US EPA. 1987. AIR QUALITY CRITERIA FOR PARTICULATE MATTER AND SULFUR OXIDES OFFICE OF HEALTH AND'ENVIRONMENTAL ASSESSMENT RESEARCH
TRIANGLE PARK, NC. EPA 600/8-82-029F.NTIS PB84-156777.

PEBULATE 001114-71-2
010036 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PEBULATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

PENDIMETHALIN ' 040487-42-1
010037 AMERICAN CYANAMID COMPANY. 1979. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 0058657 AVAILABLE FROM EPA WRITE TO FOI
EPA. WASHINGTON. DC 20460. ' '

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PENDIMETHALIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

PENTABROMODIPHENYL ETHER 032534-81-9
010038 CARLSON GP. 1980. INDUCTION OF XENOBIOTIC METABOLISM IN RATS BY BROMINATED DIPHENYL ETHERS ADMINISTERED FOR 90 DAYS TOXICOL LETT 6-
207-212.

US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

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(OTHER THAN CARCINOGENICITY) May 1995

PENTACHLOROBENZENE 000608-93-5
010039 LINGER R. T SCOTTI J GOLDSTEIN AND K MCELROY. 1980. ACUTE AND SUBCHRONIC TOXICITY OF PENTACHLOROBENZENE. J ENVIRON PATHOL TOXICOL.
4(5-6): 183-196.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PENTACHLOROBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

PENTACHLOROCYCLOPENTADIENE 025329-35-5
005302 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

PENTACHLORONITROBENZENE 000082-68-8
010040 OLIN CORPORATION. 1968. MRID NO. 000114201. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PENTACHLORONITROBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

PENTACHLOROPHENOL 000087-86-5
005600 SCHWETZ. BA. JF QUAST. PA KEELER ET AL. 1978. RESULTS OF TWO-YEAR TOXICITY AND REPRODUCTION STUDIES ON PENTACHLOROPHENOL IN RATS. IN:
PENTACHLOROPHENOL: CHEMISTRY. PHARMACOLOGY AND ENVIRONMENTAL TOXICOLOGY. KR RAO. ED PLENUM PRESS. NEW YORK. P301. CITED IN US EPA. 1985.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PENTACHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR PENTACHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC

US EPA. 1985. RfD/RfC WORK GROUP.

PENTACHLOROPROPENE, 1.1.2.3.3.- 001600-37-9
010041 US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

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(OTHER THAN CARCINOGENICITY) May 1995

PENTANE. N- 000109-66-0
005603 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR N-PENTANE. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE CINCINNATI OH OFFICE OF EMERGENCY
AND REMEDIAL RESPONSE. WASHINGTON. DC.

PHENANTHRENE 000085-01-8
005604 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENANTHRENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1994. RfD/RfC WORK GROUP.

PHENOL 000108-95-2
005824 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. TERATOLOGIC EVALUATION OF PHENOL IN CD RATS REPORT PREPARED BY THE RESEARCH TRIANGLE INSTITUTE
RESEARCH TRIANGLE PARK. NC. NTIS PB83-247726. GOVT REP ANNOUNCE INDEX 83(25). 6247

US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR PHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

US EPA. 1989. RfD/RfC WORK GROUP.

010913 US EPA. 1990. RfD/RfC WORK GROUP.

PHENYLENEDIAHINE. M- 000108-45-2
010044 HOFER H AND R HRUBY. 1982. NINETY-DAY TOXICITY STUDY WITH M-PHENYLENEDIAMINE ON RATS OESTERR FORSCHUNGS ZENT SEIBERSDORF (BER ) OEFZS
BER. NO. 4155. P 50.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0- M- P-) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

PHENYLENEDIAMINE. 0- 000095-54-5
010042 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0-. M-. P-) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

PHENYLENEDIAMINE. P- 000106-50-3
010043 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0- M- P-) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

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(OTHER THAN CARCINOGENICITY) May 1995

PHENYLMERCURIC ACETATE 000062-38-4
010277 FITZHUGH OG. AA NELSON. EP LAUG AND IM KUNZE. 1950. CHRONIC ORAL TOXICITIES OF MERCURIC PHENYL AND MERCURIC SALTS. ARCH IND HYG OCCUP
MED. 2: 433-442.

US EPA. 1986. RfD/RfC WORK GROUP.

PHORATE 000298-02-2
010403 TUSING TW. 1956. 13-WEEK SUBACUTE THIMET FEEDING STUDY IN MALE AND FEMALE RATS. UNPUBLISHED REPORT OF THE AMERICAN CYANAMID CO INITIAL
SCIENTIFIC AND MINI-ECONOMIC REVIEW OF PHORATE (THIMET). OFFICE OF PESTICIDE PROGRAMS. US EPA. WASHINGTON. DC.

US EPA. 1985. SUMMARY OF ACCEPTABLE DAILY INTAKES (ADIS) FOR ORAL EXPOSURE PREPARED BY ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
CINCINNATI. OH. INTERNAL REVIEW DRAFT. MAY, 1985. ECAO-CIN-432.

NAS (NATIONAL ACADEMY OF SCIENCES). 1977. DRINKING WATER AND HEALTH. SAFE DRINKING WATER COMMITTEE. NATIONAL RESEARCH COUNCIL NAS.
WASHINGTON. DC. P 613-620.

PHOSGENE 000075-44-5
010045 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHOSGENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.

PHOSPHINE 007803-51-2
010174 HACKENBERG. J. 1972. CHRONIC INGESTION BY RATS OF STANDARD DIET TREATED WITH ALUMINUM PHOSPHIDE. TOXICOL APPL PHARMACOL 23: 147-158.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PHOSPHINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

010173 KLIMMER. OR. 1969. CONTRIBUTION TO THE STUDY OF ACTION OF PHOSPHINE (PH3) ON THE QUESTION OF SO-CALLED CHRONIC PHOSPHINE POISONING ARCH
TOXICOL. 24: 164-187.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PHOSPHINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
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(OTHER THAN CARCINOGEN1CITY) May 1995

PHOSPHORUS. WHITE 007723-14-0
010452 CONDRAY JR. 1985. ELEMENTAL YELLOW PHOSPHORUS ONE-GENERATION REPRODUCTION STUDY IN RATS. IR-82-215 MRID NO 401-189 MONSANTO CO ST
LOUIS. MO. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460

US EPA. 1990. RfD/RfC WORK GROUP.

PHOTOCHEMICAL OXIDANTS
010172 US EPA. 1986. AIR QUALITY CRITERIA FOR OZONE AND OTHER PHOTOCHEMICAL OXIDANTS OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT RESEARCH
TRIANGLE PARK. NC. EPA 600/8-84-020F. NTIS PB87-142949.

PHTHALIC ACID. M- 000121-91-5
010047 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACIDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

PHTHALIC ACID. 0- 000088-99-3
010046 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACIDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

PHTHALIC ACID. P- 000100-21-0
010048 CUT (CHEMICAL INDUSTRY INSTITUTE OF TECHNOLOGY). 1982. A NINETY-DAY STUDY OF TEREPHTHALIC ACID-INDUCED UROLITHIASIS AND REPRODUCTIVE
PERFORMANCE IN WISTAR AND CD RATS. CUT. RESEARCH TRIANGLE PARK. NC

GROSS. J. 1974. THE EFFECTS OF PROLONGED FEEDING OF TEREPHTHALIC ACID (TPA) TO RATS PROJECT FG-IS-175 AGRICULTURAL RESEARCH SERVICE US
DEPARTMENT OF AGRICULTURE. WASHINGTON. DC.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACIDS (0-. M-. P-). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
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PHTHALIC ANHYDRIDE 000085-44-9
010049 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO.
159. NTIS PB293594.

US EPA. 1988. RfD/RfC WORK GROUP.

010847 NIELSEN. J. H WELINDER. A SCHUTZ AND S SKERFVING 1988 SPECIFIC SERUM ANTIBODIES AGAINST PHTHALIC ANHYDRIDE IN OCCUPATIONALLY EXPOSED
SUBJECTS. J ALLERGY CLIN IMMUNOL. 82: 126-33

US EPA 1992 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PHTHALIC ANHYDRIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

POlYBROMINATED BIPHENYLS
010050 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. CARCINOGENESIS STUDIES OF POLYBROMINATED BIPHENYL MIXTURE IN F344/N RATS AND B6C3F1 MICE (GAVAGE
STUDIES). FIREMASTER FF-1. CASE NO 67774-32-7 NTP. RESEARCH TRIANGLE PARK. NC.

US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR POLYBROMINATED BIPHENYLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

POTASSIUM CYANIDE 000151-50-8
010278 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.

PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS. J
TOXICOL ENVIRON HEALTH. 5. 579-592.

US EPA. 1985. RfD/RfC WORK GROUP.

POTASSIUM SILVER CYANIDE 000506-61-6
010279 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3. 325-329

PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON. 1979 EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS. J
TOXICOL ENVIRON HEALTH. 5: 579-592

US EPA. 1985. RfD/RfC WORK GROUP.

PROFLURALIN 026399-36-0
010051 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROFLURALIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

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(OTHER THAN CARCINOGENICITY) May 1995

PRONAHIDE 023950-58-5
010280 ROHM & HAAS. CO. 1970. ACC NOS 000967. 004417.

US EPA. 1986. RfD/RfC WORK GROUP.

PROPACHLOR 001918-16-7
010175 MONSANTO COMPANY. 1964. CONFIDENTIAL BUSINESS INFORMATION UNPUBLISHED STUDY MRID NO 0093270. AVAILABLE FROM EPA WRITE TO FOI EPA
WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPACHLOR PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

PROPAZINE 000139-40-2
010052 GEIGY COMPANY. 1980. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY ACCESSION NO 243353.

US EPA. 1987. RfD/RfC WORK GROUP.

PROPIONITRILE 000107-12-0
010053 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPIONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

PROPYL ALCOHOL. N- 000071-23-8
005627 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N-PROPYL ALCOHOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.
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(OTHER THAN CARCINOGEN1CITY) May 1995

PROPYLENE GLYCOL 000057-55-6
005631 GAUNT. IF. RMB CARPANINI. P GRASSO AND ABG LANSDOWN. 1972. LONG-TERM TOXICITY OF PROPYLENE GLYCOL IN RATS FOOD COSMET TOXICOL 10.
151-162.

US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PROPYLENE GLYCOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

005629 GUERRANT. NB. GP WHITLOCK. ML WOLFF AND RA DUTCHER. 1947.RESPONSE OF RATS TO DIETS CONTAINING VARYING AMOUNTS OF GLYCEROL AND PROPYLENE
GLYCOL. BULL NATL FORMULARY COMM 15: 204-229. CITED IN INFORMATICS. INC. 1973

010914 US EPA. 1991. RfD/RfC WORK GROUP.

PROPYLENE GLYCOL MONOETHYL ETHER 001569-02-4
005488 SMYTH. HF. JR AND CP CARPENTER. 1948. FURTHER EXPERIENCE WITH THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY. J IND HYG
TOXICOL. 30: 63-68.

010915 US EPA. 1991. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

PROPYLENE GLYCOL MONOMETHYL ETHER 000107-98-2
005486 ROME. VK. DO MCCOLLISTER. HC SPENCER ET AL. 1954. TOXICOLOGY OF MONO-. DI-. AND TRI-PROPYLENE GLYCOL METHYL ETHERS ARCH IND HYG OCCUR
MED. 9: 509-525.

US EPA. 1991. RfD/RfC WORK GROUP.

010276 LANDRY TO. TS GUNSHOW AND BL YANO. 1983. PROPYLENE GLYCOL MONOMETHYL ETHER. A 13-WEEK INHALATION STUDY IN RATS AND RABBITS FUND APPL
TOXICOL. 3: 627-630.

MILLER RR. EA HERMAN. JT YOUNG ET AL. 1984. ETHYLENE GLYCOL MONOMETHYL ETHER METABOLISM. DISPOSITION. AND SUBCHRONIC INHALATION TOXICITY
STUDIES. ENVIRON HEALTH PERSPECT. 57: 233-239.

US EPA. 1984 HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC. EPA 540/1-86-052.

PROPYLENE OXIDE 000075-56-9
010375 KUPER CF. PGJ REUZEL, VJ FERON. ET AL. 1988 CHRONIC INHALATION TOXICITY AND CARCINOGENICITY OF PROPYLENE OXIDE IN WISTAR RATS FOOD CHEM
TOXICOL. 26(2): 159-167.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPYLENE OXIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.

PYRENE 000129-00-0
010176 US EPA. 1989. MOUSE ORAL SUBCHRONIC TOXICITY STUDY OF PYRENE. STUDY CONDUCTED BY TOXICITY RESEARCH LABORATORIES MUSKEGON 3MI FOR THE
OFFICE OF SOLID WASTE. WASHINGTON, DC.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR PYRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PYRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1989. RfD/RfC WORK GROUP.

010968 US EPA. 1994. RfD/RfC WORK GROUP.

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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Hay 1995

PYRIDINE 000110-86-1
010055 US EPA. 1986. PYRIDINE. 90-DAY SUBCHRONIC ORAL TOXICITY IN RATS. SPONSORED BY OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PYRIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

RDX / (CYCLONITE) 000121-82-4
010056 LEVINE BS. EM FUREDI. VS RAE. DE GORDON AND DM LISH. 1984. DETERMINATION OF THE CHRONIC MAMMALIAN TOXICOLOGICAL EFFECTS OF RDX:
TWENTY-FOUR MONTH CHRONIC TOXICITY/CARCINOGENICITY STUDY OF HEXAHYDRO-1.3.5-TRINITRO-1.3.5-TRIAZINE (RDX) IN THE FISCHER 344 RAT. NTIS
AD-A160774. VOL 1. 347 P.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR RDX (CYCLONITE). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

RONNEL 000299-84-3
010057 MCCOLLISTER DO. F OYEN AND VK ROWE. 1959. TOXICOLOGICAL STUDIES OF 0.0-DIMETHYL-0-(2.4.5-TRICHLOROPHENYL)PHOSPHOTHIOATE (RONNEL) IN
LABORATORY ANIMALS. J AGRIC FOOD CHEM. 7: 689.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR RONNEL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. "OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

SELENIOUS ACID 007783-00-8
010504 YANG G. S YIN. L ZHOU. ET AL. 1989. STUDIES OF SAFE MAXIMAL DAILY DIETARY SE-INTAKE IN A SELENIFEROUS AREA IN CHINA. II. RELATION BETWEEN
SE-INTAKE AND THE MANIFESTATION OF CLINICAL SIGNS AND CERTAIN BIOCHEMICAL ALTERATIONS IN BLOOD AND URINE. J TRACE ELEM. ELECTROLYTES
HEALTH DIS. 3: 123-130.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELENIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.

US EPA. 1991. RfD/RfC WORK GROUP.
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(OTHER THAN CARCINOGENICITY) May 1995

SELENIUM 007782-49-2
010404 YANG G. S YIN. L ZHOU. ET AL. 1989. STUDIES OF SAFE MAXIMAL DAILY DIETARY SE-INTAKE IN A SELENIFEROUS AREA IN CHINA. II RELATION BETWEEN
SE-INTAKE AND THE MANIFESTATION OF CLINICAL SIGNS AND CERTAIN BIOCHEMICAL ALTERATIONS IN BLOOD AND URINE J TRACE ELEM ELECTROLYTES
HEALTH DIS. 3: 123-130.

US EPA. 1991. RfD/RfC WORK GROUP.

SELENOUREA 000630-10-4
010473 YANG C. S WANG. R ZHOU. AND S SUN. 1983. ENDEMIC SELENIUM INTOXICATION OF HUMANS IN CHINA AM J CLIN NUTR. 37: 872-888.

SILVER 007440-22-4
010453 GAUL LE AND AN STAUD. 1935. CLINICAL SPECTROSCOPY. SEVENTY CASES OF GENERALIZED ARGYRIA FOLLOWING ORGANIC AND COLLOIDAL SILVER
MEDICATION. J AM MED ASSOC 104: 1387-1390.

BLUMBERG H AND TN CAREY. 1934. ARGYREMIA: DETECTION OF UNSUSPECTED AND OBSCURE ARGYRIA BY THE SPECTROGRAPHIC DEMONSTRATION OF HIGH BLOOD
SILVER. J AM MED ASSOC. 103 1521-1524.

EAST BW. K BODDY. ED WILLIAMS. D MACINTYRE AND ALC MCLAY.1980. SILVER RETENTION, TOTAL BODY SILVER AND TISSUE SILVER CONCENTRATIONS IN
ARGYRIA ASSOCIATED WITH EXPOSURE TO AN ANTI-SMOKING REMEDY CONTAINING SILVER ACETATE CLIN EXP DERMATOL. 5: 305-311.

SILVER CYANIDE 000506-64-9
010283 HOWARD JW AND RF HANZAL 1955 CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE AGRIC FOOD CHEM 3: 325-329

PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON 1979 EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS J
TOXICOL ENVIRON HEALTH. 5: 579-592.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR SODIUM CYANIDE. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF
EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

US EPA. 1985. RfD/RfC WORK GROUP.

SIMAZINE 000122-34-9
010955 CIBA-GEIGY CORP. 1988. MRID NO 40614405, HED DOCUMENT NO 007240. 007449 AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1991. RfD/RfC WORK GROUP.
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(OTHER THAN CARCINOGENICITY) Hay 1995

SODIUM CYANIDE 000143-33-9
005640 HOWARD. JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. J AGRIC FOOD CHEM. 3. 325-329 CITED IN
US EPA. 1985.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR SODIUM CYANIDE. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF
EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC.

US EPA. 1985. INTEGRATED RISK INFORMATION SYSTEM (IRIS): REFERENCE DOSE (RFD) FOR ORAL EXPOSURE FOR SODIUM CYANIDE. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH.

US EPA. 1985. RfO/RfC WORK GROUP.

SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
005644 SUNDERMAN. FW. OE PAYNTER AND RB GEORGE. 1967. THE EFFECTS OF THE PROTRACTED ADMINISTRATION OF THE CHELATING AGENT. SODIUM
DIETHYLDITHIOCARBAMATE (DITHIOCARB). AM J MED SCI. 254: 46-56.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SODIUM DIETHYLOITHIOCARBAMATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

US EPA. 1985. RfD/RfC WORK GROUP.

SODIUM METAVANADATE 013718-26-8
005735 DOMINGO. JL. JL LLOBET, JM TOMAS AND J CORBELLA. 1985. SHORT-TERM TOXICITY STUDIES OF VANADIUM IN RATS J APPL TOXICOL. 5(6): 418-421.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

STRONTIUM. STABLE 007440-24-6
010842 STOREY E. 1961. STRONTIUM 'RICKETS1 BONE CALCIUM AND STRONTIUM CHANGES. AUSTRAL ANN MED. 10: 2132-222.

SKORYNA SC. 1981. EFFECTS OF ORAL SUPPLEMENTATION WITH STABLE STRONTIUM. CAN MED ASSOC J. 125: 703-712.

MARIE PJ. MT GARBA. M HOTT AND L MIRAVET. 1985. EFFECT OF LOW DOSES OF STABLE STRONTIUM ON BONE METABOLISM IN RATS. MINER ELECTROLYTE
METAB. 11: 5-13.

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR STABLE STRONTIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1992. RfD/RfC WORK GROUP.

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(OTHER THAN CARCINOGEN1CITY) May 1995

STRYCHNINE 000057-24-9
010285 SEIOL I AND G ZBINDEN. 1982. SUBCHRONIC ORAL TOXICITY OF STRYCHNINE IN RATS ARCH TOXICOL. 51(3): 267-271.

US EPA. 1985. RfD/RfC WORK GROUP.

STYRENE 000100-42-5
010059 QUAST JF. CG HUMISTON. RT KALNINS. ET AL. 1979. RESULTS OF A TOXICITY STUDY OF MONOMERIC STYRENE ADMINISTERED TO BEAGLE DOGS BY ORAL
INTUBATION FOR 19 MONTHS. TOXICOLOGY RESEARCH LABORATORY. HEALTH AND ENVIRONMENTAL SCIENCES. DOW CHEMICAL CO . MIDLAND. MI. FINAL REPORT.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STYRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC

US EPA 1985. RfD/RfC WORK GROUP

010511 MUTTI A. A MAZZUCCHI. P RUSTICHELLI. G FRIZERI. G ARFINI. I FRANCHINI. 1984 EXPOSURE EFFECT AND EXPOSURE RESPONSE THE RELATIONSHIP
BETWEEN OCCUPATIONAL EXPOSURE TO STYRENE AND NEUROPSYCHOLOGICAL FUNCTION AMER J IND MED 5: 275-286.

US EPA. 1992. RfD/RfC WORK GROUP.

SUCCINONITRILE 000110-61-2
005585 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

SULFUR DIOXIDE 007446-09-5
010505 REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

SULFUR OXIDES
010035 US EPA. 1987. AIR QUALITY CRITERIA FOR PARTICULATE MATTER AND SULFUR OXIDES OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. RESEARCH
TRIANGLE PARK. NC. EPA 600/8-82-029F.NTIS PB84-156777.

SULFURIC ACID 007664-93-9
005647 CARSON. BL. BL HERNDON. HV ELLIS III. ET AL. 1981. SULFURIC ACID HEALTH EFFECTS PREPARED UNDER CONTRACT 68-03-2928 BY MIDWEST RESEARCH
INSTITUTE. KANSAS CITY. MO. PREPARED FOR EMISSION CONTROL TECHNOLOGY DIVISION. OFFICE OF MOBILE SOURCE AIR POLLUTION CONTROL US EPA. ANN
ARBOR. MI. EPA 460/3-81-025. NTIS PB82-113135

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR SULFURIC ACID. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. OFFICE OF
EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

TEMEPHOS 003383-96-8
010060 GAINES TB. RD KIMBROUGH AND ER LAW. JR. 1967. TOXICOLOGY OF ABATE IN LABORATORY ANIMALS ARCH ENVIRON HEALTH. 14: 283-288

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEMEPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

TERBUFOS 013071-79-9
010408 MORGAREIDGE K. S SISTNER. M DANIELS ET AL. 1973. FINAL REPORT: SIX-MONTH FEEDING STUDY IN DOGS ON AC-92.100. LABORATORY NO. 1193.
FEBRUARY 14. UNPUBLISHED STUDY. FOOD AND DRUG LABORATORIES. INC. MRID NO 41139 AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON, DC
20460.

US EPA. 1987. HEALTH ASSESSMENT DOCUMENT FOR TERBUFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

TEREPHTHALIC ACID 000100-21-0
010474 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEREPHTHALIC ACID PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC

TETRACHLOROAZOXYBENZENE 021232-47-3
010064 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB. TCAOB AND TCHB PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

TETRACHLOROBENZENE. 1.2.4.5- 000095-94-3
010286 CHU I. DC VILLENEUVE. VE VALLI AND VE SECOURS. 1984. TOXICITY OF 1.2.3.4-. 1.2.3.5- AND 1.2.4,5-TETRACHLOROBENZENE IN THE RAT: RESULTS OF
A 90-DAY FEEDING STUDY. DRUG CHEM TOXICOL. 7: 113-127.

US EPA. 1985. RfD/RfC WORK GROUP.

TETRACHLOROCYCLOPENTADIENE 000695- 77-2
005303 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
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(OTHER THAN CARCINOGENICITY) May 1995

TETRACHLOROETHANE. 1.1.1.2- 000630-20-6
010407 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. CARCINOGENESIS STUDIES OF 1.1.1.2-TETRACHLOROETHANE IN F344/N RATS AND B6C3F1MICE. NTP.
WASHINGTON. DC.

US EPA. 1987. RfD/RfC WORK GROUP.

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR TETRACHLOROETHANE. 1.1.1.2-. PREPARED BY THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER.
WASHINGTON. DC.

TETRACHLOROETHYLENE 000127-18-4
005650 BUBEN. JA AND EJ O'FLAHERTY. 1985. DELINEATION OF THE ROLE OF METABOLISM IN THE HEPATOXICITY OF TRICHLOROETHYLENE AND PERCHLOROETHYLENE:
A DOSE-EFFECT STUDY. TOXICOL APPL PHARMACOL. 78: 105-122.

US EPA. 1987. RfD/RfC WORK GROUP.

TETRACHLOROHYDRAZOBENZENE 071753 -42-9
010065 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB. TCAOB AND TCHB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

TETRACHLOROPHENOL. 2.3.4.5- 004901-51-3
005324 US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.

TETRACHLOROPHENOL. 2.3.4.6- 000058-90-2
005323 US EPA. 1986. 2.3.4.6-TETRACHLOROPHENOL. 90-DAY SUBCHRONIC ORAL TOXICITY STUDY IN RATS OFFICE OF SOLID WASTE. WASHINGTON. DC.

TETRACHLOROPHENOL, 2.3.5.6- 000935-95-5
005325 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.

US EPA. 1987. RfD/RfC WORK GROUP.

TETRACHLOROPROPENE. 1.1.2.3- 010436-39-2
010066 US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

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(OTHER THAN CARCINOGENICITY) May 1995

TETRACHLOROVINPHOS / (STIROPHOS) 000961-11-5
010067 SHELL CHEMICAL COMPANY. 1968. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY ACCESSION NO 115684

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

TETRAETHYL DITHIOPYROPHOSPHATE 003689-24-5
010287 KIMMERLE G AND OR KLIMMER. 1974. ACUTE AND SUBCHRONIC TOXICITY OF SULFOTEP ARCH TOXICOL 33(1): 1-16.

US EPA. 1988. RfD/RfC WORK GROUP.

THALLIC OXIDE 001314-32-5
010956 US EPA. 1993. RfD/RfC WORK GROUP.

THALLIUM (I) ACETATE 000563-68-8
005664 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

THALLIUM (I) CARBONATE 006533-73-9
005668 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
Hay 1995
THALLIUM (I) CHLORIDE 007791-12-0
005672 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
FINAL REPORT. ENVIRONMENTAL
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

THALLIUM (I) NITRATE 010102-45-1
005676 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS FINAL REPORT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

THALLIUM (I) SULFATE 007446-18-6
005682 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS FINAL REPORT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

THALLIUM (IN SOLUBLE SALTS)
010458 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.
THALLIUM SELENITE
010957 US EPA.
012039-52-0
1993. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

THIOCYANOMETHYLTHIOBENZOTHIAZOLE. 2-( 021564-17-0
010068 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCMTB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

THIOFANOX 013196-18-4
010069 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THIOFANOX. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

THIRAM 000137-26-8
010459 E.I. DU PONT DE NEMOURS AND COMPANY, INC. 1954. MRID NO. 0045162. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1987. RfD/RfC WORK GROUP.

010070 HORNSHAW TC. RJ AULERICH AND RK RINGER. 1987. TOXICITY OF THIRAM (TETRAMETHYLTHINORAM DISULFIDE) TO MINK AND EUROPEAN FERRETS. BULL
ENVIRON CONTAM TOXICOL. 38(4): 618-626.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THIRAM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

TIN AND COMPOUNDS
005688 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF STANNOUS CHLORIDE (CAS NO 7772-99-8) IN F344/N RATS AND B6C3F1/N MICE
(FEED STUDY). NCI/NTP TECH REP SER NO 231. ALSO PUBL AS DHHS (NIH) PUBL ISS NIH 82-1787 AND NTIS PB 82-242-553.

US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TIN. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH. OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

TOLUENE 000108-88-3
010469 NTP (NATIONAL TOXICOLOGY PROGRAM). 1989 TOXICOLOGY AND CARCINOGENESIS STUDIES OF TOLUENE IN F344 RATS AND B6C3F1 MICE TECHNICAL REPORT
SERIES NO 371.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR TOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1990. RfD/RfC WORK GROUP.

010844 FOO S. J JEYARATHAM AND D KOH. 1990. CHRONIC NEUROBEHAVIORAL EFFECTS OF TOLUENE BR J IND MED 47(7). 480-484.

NTP (NATIONAL TOXICOLOGY PROGRAM). 1990. TOXICOLOGY AND CARCINOGENESIS STUDIES OF TOLUENE IN F344/N RATS AND B6C3F1 MICE (INHALATION
STUDIES). NTP TR 371. 253 P.

US EPA. 1991. RfD/RfC WORK GROUP.

TOLUENE-2.5-DIAMINE 000095-70-5
010073 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF TOLUENE-2.5-DIAMINE SULFATE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP
SER NO 126.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC

TOLUENE-2.6-DIAMINE 000823-40-5
010074 NCI (NATIONAL CANCER INSTITUTE). 1980. BIOASSAY OF 2.6-TOLUENEDIAMINE DIHYDROCHLORIDE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS
TECH REP SER NO 200.

TOLUENEDIAMINE. 2.3- 002687-25-4
010071 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC

TOLUENEDIAMINE. 3.4- 000496-72-0
010072 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) Hay 1995

TOLUIDINE. M- 000108-44-1
010075 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIDINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

TRIALLATE 002303-17-5
010076 MONSANTO COMPANY. 1979. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY ACCESSION NO 242057

US EPA. 1986. RfD/RfC WORK GROUP.

TRIBROMOBENZENE. 1.2.4- 000615-54-3
010077 CARLSON GP AND RG TARDIFF. 1977. EFFECT OF 1.4-DIBROMODIBENZENE AND 1.2.4-TRIBROMOBENZENE ON XENOBIOTIC METABOLISM. TOXICOL APPL
PHARMACOL. 42: 189-196.

US EPA. 1984. HEALFH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

TRICHLORO-1.2.2-TRIFLUOROETHANE, 1.1.2- 000076-13-1
010460 INBUS HR AND C ATKINS. 1972. PHYSICAL EXAMINATION OF WORKERS EXPOSED TO TRICHLOROTRIFLUOROETHANE. ARCH ENVIRON HEALTH 24(4): 257-261.

010376 TRACHIMOWICZ HJ. GM RUSCH. T CHIU. ET AL. 1988. CHRONIC INHALATION TOXICITY/CARCINOGENICITY STUDY IN RATS EXPOSED TO FLUOROCARBON 113
(FC-113). FUND APPL TOXICOL. 11(1). 68-75.

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.1.2-TRICHLORO-1.2,2-TRIFLUOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

TRICHLORO-2'-HYDROXYDIPHENYLETHER. 2.2.4'- 003380-34-5
005492 LYMAN. FL AND T FURIA. 1969. TOXICOLOGY OF 2.4.4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER IND MED. 38: 45-52.

US EPA. 1987 HEALTH EFFECTS AND ENVIRONMENTAL DOCUMENT FOR HALOETHERS. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH.
OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN 1C ITY)
May 1995
TRICHLOROBENZENE. 1.2.4- 000120-82-1
010506 ROBINSON. KS. RJ KAVLOCK. N CHERNOFF AND E GRAY. 1981. MULTIGENERATION STUDY OF TRICHLOROBENZENE IN RATS. J. TOXICOL. ENVIRON. HEALTH. 8:
5S5
010958
^
°F
IN THE RAT. RABBIT AND BEAGLE DOG. DRUG

M°NKEYS T° 1.2.4-TRICHLOROBENZENE ARCHIVES OF

mi)VEiiErS' VE VALLL 1988' TRICHLOROBENZENES: RESULTS * A THIRTEEN WEEK FEEDING STUDY IN THE RAT. DRUG

US EPA. 1993. RfD/RfC WORK GROUP.

TRICHLOROCYCLOPENTADIENE 077323-84-3
005304 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES PREPARED RY THF

E"VIMME"TAL CRITERIA A"° ASS£SS"ENT OFFICE- ™ "
TRICHLORO£1HAN£. 1.1.2-

0057(12
- *"
000079-00-5
1965 TOXICOLOGY OF '-1-2 T«1CHLO«OETH«IE M THE HOUSE. MUG CHE« TOXICOL.

US EPA. 1990. RfD/RfC WORK GROUP.
STa™S * "IC£ ExroSED T0
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

TRICHLOROFLUOROMETHANE 000075-69-4
005502 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF TRICHLOROFLUOROMETHANE FOR POSSIBLE CARCINOGEN1CITY. NCI CARCINOGENESIS TECH REP SER
NO 106. ALSO PUBL AS DHEW (NIH) 78-1356.

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

US EPA. 1985. RfD/RfC WORK GROUP.

005500 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF TRICHLOROFLUOROMETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER
NO 106. ALSO PUBL AS DHEW (NIH) 78-1356.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH.
OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

TRICHLOROPHENOL. 2.3.4- 015950-66-0
005330 US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

TRICHLOROPHENOL. 2.3.5- 000933-78-8
005331 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

TRICHLOROPHENOL. 2.3.6- 000933-75-5
005332 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

TRICHLOROPHENOL. 2.4.5- 000095-95-4
005329 MCCOLLISTER. DO. DT LOCKWOOD AND VK ROME. 1961 TOXICOLOGIC INFORMATION ON 2,4.5-TRICHLOROPHENOL. TOXICOL APPL PHARMACOL. 3. 63-70.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 2.4.5-TRICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1985. RfO/RfC WORK GROUP.

010919 US EPA. 1991. RfD/RfC WORK GROUP.

TRICHLOROPHENOL. 2.4.6- 000088-06-2
010461 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1991. RfD/RfC WORK GROUP.

TRICHLOROPHENOL. 3.4.5- 000609-19-8
005333 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

TRICHLOROPHENOXY) PROPIONIC ACID. 2(2.4.5- 000093-72-1
010284 GEHRING PJ AND JE BETSO. 1978. PHENOXY ACIDS: EFFECTS AND FATE IN MAMMALS IN: CHLORINATED PHENOXY ACIDS AND THEIR DIOXINS VOL 27 C
RAMEL ED. ECOL BULL. STOCKHOLM. P. 122-133.

MULLISON WR. 1966. SOME TOXICOLOGICAL ASPECTS OF SILVEX. IN: PROC 19TH ANN MEET SOUTHERN WEED CONFERENCE. JACKSONVILLE. FL. P. 420-435.

US EPA. 1988. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) May 1995

TRICHLOROPHENOXYACETIC ACID. 2.4.5- 000093-76-5
010178 KOCIBA. RS. OG KEYES. RW LISOWE. ET AL. 1979. RESULTS OF 2-YEAR CHRONIC TOXICITY AND ONCOGENICITY STUDY OF RATS INGESTING DIETS
CONTAINING 2.4.5-T. FOOD COSMET TOXICOL. 17: 205 -222.

SMITH FA. FJ MURRAY. JA JOHN. ET AL. 1981. THREE-GENERATION REPRODUCTION STUDY OF RATS INGESTING 2,4.5-TRICHLOROPHENOXYACETIC ACID IN THE
DIET. TOXICO RES LAB.. DOW CHEMICAL. MIDLAND. MI

US EPA 1989 HEALTH EFFECTS ASSESSMENT FOR 2 4 5-TRICHLOROPHENOXY ACETIC ACID PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
DC.

US EPA. 1988. RfD/RfC WORK GROUP.

010179 GEHRING. PJ. AND JE BETSO. 1978. PHENOXY ACIDS. EFFECTS AND FATE IN MAMMALS ECO BULL 27 122-123

US EPA 1989 HEALTH EFFECTS ASSESSMENT FOR 2.4.5-TRICHLOROPHENOXY ACETIC ACID PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
DC.

TRICHLOROPROPANE. 1.1.1- 007789-89-1
005705 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.
OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

TRICHLOROPROPANE. 1.1.2- 000598-77-6
005708 VILLANEUVE. DC. I CHU. VE SECOURS. MG COTIE. GL PLAA AND VE VALLI. 1985. RESULTS OF A 90-DAY TOXICITY STUDY ON 1.2.3- AND
1.1.2-TRICHLOROPROPANE ADMINISTERED VIA THE DRINKING WATER. SCI TOTAL ENVIRON 47, 421-426

US EPA. 1987. RfD/RfC WORK GROUP.

TRICHLOROPROPANE. 1.2.2- 003175-23-3
005706 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.
OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) Nay 1995

TRICHLOROPROPANE. 1.2.3- 000096-18-4
005714 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. FINAL REPORT 120-DAY TOXICITY GAVAGE STUDY OF 1 2 3-TRICHLOROPROPANE IN FISCHER 344 RATS
PERFORMED BY HAZELTON LABORATORIES.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI
OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.

TRICHLOROPROPENE. 1.2.3- 000096-19-5
010078 MCKENNA MJ. JF QUAST AND GA STEVENS. 1978. RESULTS OF A90-DAY INHALATION TOXICITY STUDY OF 1.2.3-TRICHLOROPROPENE IN LABORATORY ANIMALS
TOXICOL APPL PHARMACOL. 45: 249.

US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

TRICHLOROTOLUENE. 2,3.6- 002077-46-5
005335 CHU I. SY SHEN. DC VILLENEUVE. VE SECOURS AND VE VALLI. 1984. TOXICITY OF TRICHLOROTOLUENE ISOMERS: A 28-DAY FEEDING STUDY IN THE RAT J
ENVIRON SCI HEALTH PART B PESTIC FOOD CONTAM AGRIC WASTES. 19(2): 183-192.

TRICHLOROTOLUENE. ALPHA.2.6- 002014-83-7
005339 CHU I. SY SHEN. DC VILLENEUVE. VE SECOURS AND VE VALLI. 1984. TOXICITY OF TRICHLOROTOLUENE ISOMERS: A 28-DAY FEEDING STUDY IN THE RAT J
ENVIRON SCI HEALTH PART B PESTIC FOOD CONTAM AGRIC WASTES. 19(2): 183-192.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED TOLUENES. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
CINCINNATI. OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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(OTHER THAN CARCINOGENICITY) May 1995

TRIFLURALIN 001582-09-8
010080 HOECHST AKTIENGESELLSCHAFT. 1984. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 00151908. AVAILABLE FROM EPA. WRITE TO
FOI, EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1989. RfO/RfC WORK GROUP.

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOG1C EFFECTS FOR TRIFLURALIN. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

TRIMETHYLBENZENES
005727 US EPA. 1987. HEALTH AND ENVIRONMENTAL ASSESSMENT FOR TRIMETHYLBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

TRINITROBENZENE. 1.3.5- 000099-35-4
010081 CODY TE. S WITHERUP. L HASTINGS. K STEMMER AND RT CHUSTION 1981. 1.3-DINITROBENZENE TOXIC EFFECTS IN VITRO. J TOXICOL ENVIRON HEALTH.
7: 829-847.

US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3.5-TRINITROBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.

TRINITROPHENOLS
010082 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRINITROPHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC

TRINITROPHENYLMETHYLNITRAMINE 000479-45-8
010377 FATI S. E DANIELE. 1965. HISTOPATHOLOGICAL CHANGES IN EXPERIMENTAL CHRONIC TETRYL POISONING FOLIA MED. 48(4): 260-276.

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRINITROPHENYLMETHYLNITRAMINE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
Rl-101
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

TRINITROTOLUENE. 2.4.6- 000118-96-7
010416 US 000 (DEPARTMENT OF DEFENSE). 1983. AD-A157-002. DEFENSE TECHNICAL CENTER. CAMERON STATION. ALEXANDRIA. VA

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2.4.6-TRINITROTOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE WASHINGTON
DC.

US EPA. 1988. RfD/RfC WORK GROUP.

VANADIUM 007440-62-2
005739 SCHROEDER. HA. M MITCHENER AND AP NASON. 1970. ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR. 100: 59-69.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

VANADIUM PENTOXIDE 001314-62-1
005743 STOKINGER. HE. WD WAGNER. JT MOUNTAIN ET AL. 1953. UNPUBLISHED RESULTS. DIV OCCUR HEALTH. CINCINNATI. OH. CITED IN STOKINGER. 1981.

US EPA. 1986. RfD/RfC WORK GROUP.

VANADIUM SULFATE 036907-42-3
005747 SCHROEDER. HA. M MITCHENER AND AP NASON. 1970 ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR 100: 59-69.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

VERNAM / (VERNOLATE) 001929-77-7
010083 STAUFFER CHEMICAL COMPANY. 1983. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY ACCESSION NOS 249703-249704.

US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR VERNOLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

VINYL ACETATE 000108-05-4
010417 SHAW DC. 1988. VINYL ACETATE: 104-WEEK ORAL (DRINKING WATER) COMBINED CHRONIC TOXICITY AND CARCINOGENICITY STUDY IN THE RAT FOLLOWING IN
VITRO EXPOSURE. VOLUME I. HAZELETON LABORATORIES. UK. REPORT NO. 5531-5/16 EPA DOC NO 86-0000265. FICHE NO OTS0514156.

US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR VINYL ACETATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC.

010418 OWEN PE 1988. VINYL ACETATE- 104 WEEK INHALATION COMBINED CHRONIC TOXICITY AND CARCINOGENICITY STUDY IN THE RAT AND MOUSE REPORT
PREPARED BY HAZELTON LABORATORIES EUROPE. LTD.. HARROGATE. ENGLAND FOR THE SOCIETY OF THE PLASTICS INDUSTRY. INC.. NEW YORK. REPORT NO.
5547-51/15. NOVEMBER. 1988.

BEEMS. RB. 1988. REPORT NO V88-133: HISTOPATHOLOGY OF THE RESPIRATORY TRACT OF MICE USED IN A 104-WEEK INHALATION STUDY (OWEN. 1988) WITH
VINYL ACETATE. (TNO-CIVO INSTITUTES. APRIL. 1988).

DREEF. VAN DER MEULEN. HC. 1988. REPORT NO V88. 033/270836: HISTOPATHOLOGY OF THE RESPIRATORY TRACT OF RATS USED IN A 104 WEEK
INHALATION STUDY (OWEN. 1988) WITH VINYL ACETATE: REVISED VERSION (TNO-CIVO INSTITUTES. OCTOBER. 1988).

US EPA. 1990. RfD/RfC WORK GROUP.

VINYL-1-CYCLOHEXENE. 4- 000100-40-3
010084 US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-VINYL-1-CYCLOHEXENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

WARFARIN 000081-81-2
010409 HUFF. BB. ED. 1985. PHYSICIANS DESK REFERENCE, 39TH ED. MEDICAL ECONOMICS CO . INC.. ORADELL. NJ.

US EPA. 1986. RfD/RfC WORK GROUP.

XYLENE. M- 000108-38-3
005755 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS OF XYLENES (MIXED) (60 2IM-XYLENE.
13.61 P-XYLENE. 17.0% ETHYLBENZENE AND 9.IX 0-XYLENE) (CAS NO. 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) US DHHS. PHS.
NIH. NTP. RESEARCH TRIANGLE PARK. NC. NTP TR 327. NIH PUBL NO 86-2583.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR XYLENES (0-. M-. P-) ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
CINCINNATI. OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

010920 US EPA. 1991. RfD/RfC WORK GROUP.
Rl-103
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

XYLENE. MIXTURE 001330-20-7
010872 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS OF XYLENES (MIXED) (60 2SM-XYLENE
13.6% P-XYLENE. 17.OX ETHYLBENZENE AND 9.IX 0-XYLENE) (CAS NO. 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) US DHHS PHS
NIH. NTP. RESEARCH TRIANGLE PARK. NC. NTP TR 327. NIH PUBL NO 86-2583.

US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR XYLENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1987. RfD WORK GROUP.

010921 US EPA. 1991. RfD/RfC WORK GROUP.

XYLENE. 0- 000095-47-6
005751 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS OF XYLENES (MIXED) (60 2% M-XYLENE
13.61 P-XYLENE. 17.OX ETHYLBENZENE AND 9.1X 0-XYLENE) (CAS NO. 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) US DHHS PHS
NIH. NTP. RESEARCH TRIANGLE PARK. NC. NTP TR 327. NIH PUBL NO 86-2583.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR XYLENES (0-. M-. P-) ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
CINCINNATI. OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

010922 US EPA. 1991. RfD/RfC WORK GROUP.

XYLENE. P- 000106-42-3
010923 US EPA. 1991. RfD/RfC WORK GROUP.

ZINC (METALLIC) 007440-66-6
010937 YADRICK. MF. MA KENNEY AND EA WINTERFELDT. 1989. IRON. COPPER AND ZINC STATUS. RESPONSE TO SUPPLEMENTATION WITH ZINC OR ZINC AND IRON IN
ADULT FEMALES. AM J CLIN NUTR. 49: 145-150.

US EPA. 1991. RfD/RfC WORK GROUP.

ZINC CYANIDE 000557-21-1
010289 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329

PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS J
TOXICOL ENVIRON HEALTH. 5: 579-592.

US EPA. 1985. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ZINC PHOSPHIDE 001314-84-7
010290 BAI KM. MK KRISHNAKUMARI. JP RAMESH. T SHIVANANDAPPA AND SK MAJUNDER. 1980 SHORT-TERM TOXICITY STUDY OF ZINC PHOSPHIDE IN ALBINO RATS.
INDIAN J EXPTL BIOL. 18: 854-857.

US EPA. 1986. RfD/RfC WORK GROUP.

ZINEB 012122-67-7
010085 BLACKWELL-SMITH RJ JR. JK FINNEGAN. PS LARSON. ET AL. 1953. TOXICOLOGIC STUDIES ON ZINC AND DISODIUM ETHYLENE BISDITHIOCARBAMATES J
PHARMACOL EXP THER. 109: 159-166.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ZINEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

US EPA. 1986. RfD/RfC WORK GROUP.
Rl-105
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HEAST TABLE 2:
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
May 1995
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
ACETONE CYANOHYDRIN
NOEL 4.0 MG/KG/DAY
INHALATION:
INTERMITTENT
000075-86-5
RAT
14 WEEKS
CENTRAL NERVOUS
SYSTEM
EFFECTS
Subchronic
[RfC] [RfD]
(mg/cu m) (mg/ko/dav)
UF UF
1E-1
100
Chronic
[RfC] [RfD]
(mg/cu m) (mq/kq/dav)
UF UF
REFERENCE
1E-2
1000
010432
SUBCHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST) AN ERROR IN THE UNCERTAINTY FACTOR THAT WAS
REPORTED IN HEED (1988) WAS CORRECTED.
CHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
ACETONITRILE
NOAEL 100 PPM
INHALATION:
INTERMITTENT
000075-05-8
MOUSE
92 DAYS
LIVER
INCREASED RELATIVE WEIGHT
5E-1
300
5E-2
3000
005208
SUBCHRONIC [RfC] COMMENT: 1E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT: 1E-2 MG/KG/DAY. (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST) UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY.
BARIUM
NOEL 0.8 MG/CU M
INHALATION:
INTERMITTENT
007440-39-3
RAT
4 MONTHS
FETUS
FETOTOXICITY
5E-3
100
5E-4
1000
005249
SUBCHRONIC [RfC] COMMENT: 1E-3 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST) BASED ON A REPRODUCTION STUDY.
CHRONIC [RfC] COMMENT: 1E-4 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST). BASED ON A REPRODUCTION STUDY.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
2-1
-------
HEAST TABLE 2:
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY)
Hay 19%
CHEMICAL
LEVEL
ROUTE
SPECIES
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfO]
(mq/cu m) (mg/ka/dav)
UF UF
Chronic
[RfC] [RfD]
(ma/cu m) (mg/ka/dav)
UF UF
REFERENCE
CHLORO-1.3-BUTADIENE /
NOAEL 10 PPM
INHALATION:
INTERMITTENT
(CHLOROPRENE)
RAT
2 YEARS
HAIR
WHOLE BODY
000126-99-8

ALOPECIA
DECREASED WEIGHT GAIN
2E-2
100
2E-2
100
005878
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION ASSUMING AN INHALATION ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION ASSUMING AN INHALATION ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: SEE ALSO HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLOROBENZENE
LOAEL 75 PPM
INHALATION:
INTERMITTENT
000108-90-7
RAT
120 DAYS
LIVER
KIDNEY
EFFECTS
EFFECTS
2E-2
10000
005353
CHRONIC [RfC] COMMENT: 5E-3 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST). UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
CYCLOPENTADIENE
NOEL 87.3 MG/KG/DAY
INHALATION:
INTERMITTENT
000542-92-7
RAT
194 DAYS
LIVER
KIDNEY
LESIONS
LESIONS
3E+0
100
005401
SUBCHRONIC [RfC] COMMENT: 9E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC INHALATION [RfC] VALUE WAS DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM INHALATION
METHODOLOGY USED BY THE RfD/RfC WORK GROUP.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
2-2
-------
HEAST TABLE 2:
CHEH1CAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY)
Hay 1995
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(mg/cu m) (mq/kg/day)
UF UF
Chronic
[RfC] [RfD]
(niq/cu m) (ma/ko/dav)
UF UF
REFERENCE
DICHLOROBENZENE. 1.2-
NOEL 49 PPM RAT
INHALATION: UP TO 7
INTERMITTENT MONTHS
000095-50-1
WHOLE BODY
DECREASED WEIGHT GAIN
2E+0
100
2E-1
1000
005412
CHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
DICHLORODIFLUOROMETHANE
LOAEL 482.3 MG/KG/DAY
INHALATION:
INTERMITTENT
000075-71-8
GUINEA PIG
6 WEEKS LIVER
LESIONS
2E+0
1000
2E-1
10000
005497
SUBCHRONIC [RfC] COMMENT: 5E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT: 5E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
DICHLOROETHANE. 1.1-
NOEL 138 MG/KG/DAY
INHALATION:
INTERMITTENT
000075-34-3
CAT
13 WEEKS
KIDNEY
DAMAGE
5E+0
100
5E-1
1000
005789
SUBCHRONIC [RfC] COMMENT: 1E+0 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT: 1E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP ALSO SEE HEAST TABLE 1: CHRONIC AND SUBCHRONIC TOXICITY AND
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
2-3
-------
HEAST TABLE 2:
CHEMICAL DQSi SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
May 1995
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(mg/cu m) (mg/ka/dav)
UF UF
Chronic
[RfC] [RfD]
(mq/cu m) (mg/kg/day)
UF UF
REFERENCE
DICYCLOPENTADIENE
LOAEL 1 PPM
INHALATION:
INTERMITTENT
000077-73-6
RAT
90 DAYS
LIVER
DYSFUNCTION
2E-3
1000
2E-4
10000
005424
SUBCHRONIC [RfC] COMMENT: 6E-4 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 6E-5 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY
ETHOXYETHANOL ACETATE. 2- 000111-15-9
NOEL 30.1 MG/KG/DAY RAT
INHALATION: DAY 6-18 OF FETUS
INTERMITTENT GESTATION
DECREASED OSSIFICATION
3E-1
100
3E-1
100
005952
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. THE SUBCHRONIC ORAL [RfD]WAS BASED ON A REPRODUCTION STUDY WITH
EXPOSURES DURING DAYS 6-18 OF GESTATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. THE CHRONIC ORAL [RfD] WAS BASED ON A REPRODUCTION STUDY WITH EXPOSURES
DURING DAYS 6-18 OF GESTATION.
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES. ALSO SEE
TABLE
1: SUBCHRONIC AND CHRONIC TOXICITY VALUES.
FURFURAL
NOAEL 20 PPM
INHALATION:
INTERMITTENT
000098-01-1
HAMSTER
13 WEEKS
NASAL CAVITY
OLFACTORY DEGENERATION
5E-1
100
5E-2
1000
005465
SUBCHRONIC [RfC] COMMENT: 1E-1 MG/KG/DAY (SEE APPENDIX A-ll. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT: 1E-2 MG/KG/DAY (SEE APPENDIX A-ll. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP ALSO SEE TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254
2-4
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY)
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
May 1995
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (ma/ka/dav) (mg/cu m) (ma/kq/dav)
UF UF UF UF
METHACRYLONITRILE
NOEL 3.2 PPM
INHALATION:
INTERMITTENT
DOG
90 DAYS
000126-98-7

LIVER
LIVER
INCREASED SCOT
INCREASED SGPT
7E-3
300
7E-4
3000
005811
SUBCHRONIC [RfC] COMMENT: 2E-3 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST) THESE VALUES DIFFER FROM THOSE IN THE 1987
HEED.
CHRONIC [RfC] COMMENT: 2E-4 MG/KG/OAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST) THESE VALUES DIFFER FROM THOSE IN THE 1987
HEED.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY.
METHOXYETHANOL ACETATE. 2- 000110-49-6
NOAEL 10 PPM RABBIT
INHALATION: 13 WEEKS TESTIS
INTERMITTENT
DEGENERATION
2E-2
100
2E-3
1000
010001
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5. CALCULATED FROM DATA OBTAINED WITH
METHOXYETHANOL CONVERTED BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118 13/76.09)
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5. CALCULATED FROM DATA OBTAINED WITH
METHOXYETHANOL CONVERTED BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118 13/76.09).
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
METHOXYETHANOL. 2-
NOAEL 31 MG/CU M
INHALATION:
INTERMITTENT
000109-86-4
RABBIT
13 WEEKS
TESTICLE
EFFECTS
1E-2
100
1E-3 010910
1000
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE. (513) 569-7254.
2-5
-------
HEAST TABLE 2:
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
Hay 1995
CHEMICAL DQSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(mq/cu m) {ma/kg/day)
UF UF
Chronic
[RfC] [RfO]
(IHQ/CU m) (mg/kg/dav)
UF UF
REFERENCE
METHYL ACRYLATE
NOEL 15 PPM
INHALATION:
INTERMITTENT
000096-33-3
RAT
2 YEARS
NONE OBSERVED
3E-2
100
3E-2
100
010003
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT- NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
METHYL ISOBUTYL KETONE
NOEL 50 PPM
INHALATION:
INTERMITTENT
RAT
90 DAYS
000108-10-1

LIVER
KIDNEY
INCREASED WEIGHT
EFFECTS
8E-1
100
8E-2
1000
005562
SUBCHRONIC [RfC] COMMENT: 2E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSION ON HEAST).
CHRONIC [RfC] COMMENT: 2E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSION ON HEAST).
GENERAL COMMENT- THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
2-6
-------
HEAST TABLE 2:
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY)
Hay 1995
LEVEL
BQSI SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
METHYL STYRENE (MIXED ISOMERS) 025013-15-4
LOAEL 5.6 HG/KG/DAY MOUSE
INHALATION: 103 WEEKS
INTERMITTENT
NASAL CAVITY LESIONS
Subchronic
[RfC] [RfD]
(mg/cu m) (iiH/kQ/day)
UF UF
6E-3
1000
Chronic
[RfC] [RfD]
(mq/cu m) (mo/ka/dav)
UF UF
REFERENCE
6E-3
1000
005567
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0 5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0 5
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES
LOAEL 11.2 MG/KG/DAY MOUSE
INHALATION: 103 WEEKS
INTERMITTENT
NASAL CAVITY
LESIONS
4E-2
1000
4E-2
1000
005566
SUBCHRONIC [RfC] COMMENT: 1E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT: 1E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP
METHYL STYRENE. ALPHA
NOEL 970 MG/CU M
INHALATION:
INTERMITTENT
000098-83-9
RAT
197 DAYS
LIVER
KIDNEY
INCREASED WEIGHT
INCREASED WEIGHT
7E-1
100
7E-2
1000
010016
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
2-7
-------
HEAST TABLE 2:
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
CRITICAL EFFECT
Subchronlc
[RfC] [RfD]
(mg/cu m) (mq/ka/dav)
UF UF
Hay 1995
Chronic
[RfC] [RfD]
(IHQ/CU m) (ma/kg/dav)
UF UF
REFERENCE
METHYLENE BROMIDE
NOAEL 11 MG/KG/DAY
INHALATION:
INTERMITTENT
000074-95-3
RAT
90 DAYS
BLOOD
INCREASED CARBOXYHEMOGLOBIN
1E-1
100
1E-2
1000
010011
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. INCLUDING AN ABSORPTION FACTOR OF 0 5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. INCLUDING AN ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
NITROBENZENE
LOAEL 25 MG/CU M
INHALATION:
INTERMITTENT
MOUSE
90 DAYS
000098-95-3

BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
2E-2
1000
2E-3
10000
010518
INHALATION:
INTERMITTENT
RAT
90 DAYS
BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
SUBCHRONIC [RfC] COMMENT: 6E-3 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT: 6E-4 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY.

TRICHLOROBENZENE. 1.2.4- 000120-82-1
GENERAL COMMENT: INFORMATION REMOVED FROM THIS TABLE. SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
MS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
2-8
-------
HEAST TABLE 2:
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
May 1995
CRITICAL EFFECT
Subchromc
[RfC] [RfO]
(mq/cu m) (mg/kq/day)
UF UF
Chronic
[RfC] [RfO] REFERENCE
(mg/cu m) (mq/kq/dav)
UF UF
TRICHLOROFLUOROMETHANE
LOAEL 1940 MG/KG/DAY
INHALATION:
CONTINUOUS
DOG
90 DAYS
000075-69-4

KIDNEY
LUNG
INCREASED BUN
INFLAMMATION
7E+0
1000
7E-1
10000
005501
SUBCHRONIC [RfC] COMMENT: 2E+0 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 2E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC I£BK GROUP ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
2-9
-------
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

ACETONE CYANOHYDRIN 000075-86-5
010432 BLANK TL AND DC THAKE. 1984. THREE-MONTH INHALATION TOXICITY OF ACETONE CYANOHYDRIN IN MALE AND FEMALE SPRAGUE-DAWLEY RATS. MONSANTO
REPORT NOP. MSL-4423. TSCA 8(D) SUBMISSION 878216397 (OTS 0510325).

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ACETONITRILE 000075-05-8
005208 COATE WB. 1983. 90-DAY SUBCHRONIC TOXICITY STUDY OF ACETONITRILE IN B6C3F1 MICE FINAL REPORT (REVISED).

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACETONITRILE.PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

BARIUM 007440-39-3
005249 TARASENKO M. 0 PROMIN AND A SILAYEV. 1977. BARIUM COMPOUNDS AS INDUSTRIAL POISONS (AN EXPERIMENTAL STUDY). J HYG EPIDEM MICROBIOL
IMMUNOL. 21: 361.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR BARIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

CHLORO-1.3-BUTADIENE / (CHLOROPRENE) 000126-99-8
005878 DU PONT DE NEMOURS AND COMPANY. INC. 1985. 2-YEAR INHALATION CARCINOGENICITY STUDY OF CHLOROPRENE IN RATS. El DU PONT DE NEMOURS AND CO..
INC.. WILMINGTON. DE.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-CHLORO-1.3-BUTADIENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CHLOROBENZENE 000108-90-7
005353 DILLEY. JV. 1977. TOXIC EVALUATION OF INHALED CHLOROBENZENE. NIOSH. OHEW. CINCINNATI. OH. CONTRACT 210-76-0126. CITED IN US EPA. 1985.

US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

CYCLOPENTADIENE 000542-92-7
005401 DOW. 1987. UNPUBLISHED DATA. DOW CHEMICAL. USA. MIDLAND, MI.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

R2-1
-------
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

DICHLOROBENZENE. 1.2- 000095-50-1
005412 HOLLINGSWORTH RL. VK ROME. F OYEN. TR TORKELSON AND EM ADAMS. 1958. TOXICITY OF 0-DICHLOROBENZENE AM MED ASSOC ARCH IND HEALTH. 17(1):
180-187.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DICHLOROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

DICHLORODIFLUOROMETHANE 000075-71-8
005497 PRENDERGAST JA. RA JONES. LJ JENKINS AND J SIEGAL. 1967. EFFECTS ON EXPERIMENTAL ANIMALS OF LONG-TERM INHALATION OF TRICHLOROETHYLENE.
CARBON TETRACHLORIDE. 1.1.1-TRICHLOROETHANE. DICHLORODIFLUOROMETHANE AND 1,1-DICHLOROETHYLENE TOXICOL APPL PHARMACOL 10: 270-289

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

DICHLOROETHANE. 1.1- 000075-34-3
005789 HOFMANN HT. H BIRNSTIEL AND P JOBST 1971. ON THE INHALATION TOXICITY OF 1,1- AND 1.2-OICHLOROETHANE. ARCH TOXIKOL 27. 248-265.

DICYCLOPENTADIENE 000077-73-6
005424 DODD DE. LC LONGO AND DL EISLER. 1982 DICYCLOPENTADIENE VAPOR NINETY-DAY INHALATION STUDY ON RATS AND MICE BUSHY RUN RESEARCH CENTER.
EXPORT. PA. TSCA 8E SUBMISSION BY EXXON CHEM AMER DOC ID 88-8300464. ODD DOC ID 8EHQ-0283-0364.MICROFICHE NO OTS 204864

US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

ETHOXYETHANOL ACETATE. 2- 000111-15-9
005952 UNION CARBIDE. 1984. A TERATOGENIC EVALUATION OF CELLOSOLVE ACETATE IN FISHER 344 RATS AND NEW ZEALAND WHITE RABBITS FOLLOWING INHALATION
EXPOSURE. BUSHY RUN RESEARCH CENTER, EXPORT. PA. OCTOBER 1984 FYI-AX-1184-0360

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
R2-2
-------
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 1995

FURFURAL 000098-01-1
005465 FERON VJ. A KRUYSSE AND HC DREEF VANDER MEULEN. 1979. REPEATED EXPOSURE TO FURFURAL VAPOR: 13 WEEK STUDY IN SYRIAN GOLDEN HAMSTERS.
ZENTRASE. BAKTEVIOL PAVASITEN KD INFECTION SKV HYG ABT 1 ORIG REIHE B. 168(5-6) 442-451

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR FURFURAL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.DC.

METHACRYLONITRILE 000126-98-7
005811 POZZANI. UC. CR KINKEAD AND JM KING. 1968. THE MAMMALIAN TOXICITY OF METHACRYLONITRILE AM IND HYG ASSOC J. 29(3): 202-210.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

METHOXYETHANOL ACETATE. 2- 000110-49-6
010001 MILLER RR. LL CALHOUN AND BL YANO. 1982. ETHYLENE GLYCOL MONOMETHYL ETHER 13-WEEK VAPOR INHALATION STUDY IN MALE RABBITS REPORT
PREPARED FOR THE CHEMICAL MANUFACTURERS ASSOCIATION. MARCH 25. 1982

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- METHOXYETHANOL ACETATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

METHOXYETHANOL. 2- 000109-86-4
010910 MILLER RR. LL CALHOUN. BL YANO. 1982. ETHYLENE GLYCOL MONOETHYL ETHER 13 WEEK VAPOR INHALATION STUDY IN MALE RABBITS. REPORT PREPARED
FOR THE CMA MARCH 25. 1982.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXYETHANOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

METHYL ACRYLATE 000096-33-3
010003 KLIMISCH HJ AND W REININGHAUS. 1984. CARCINOGENICITY OF ACRYLATES: LONG-TERM INHALATION STUDIES ON METHYL ACRYLATE (MA) AND N-BUTYL
ACRYLATE (BA) IN RATS. TOXICOLOGIST. 4(1): 53.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ACRYLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
R2-3
-------
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENIC ITY) "•> 1995

CORP. 1983. NINETY-DAY INHALATION^^S AND MICE SPONSORED BY CMA US EPA/OTS PUBLIC FILES 0750507469.

FFFFCTS ASSESSMENT FOR METHYL ETHYL KETONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
INSTITUTE). 1984. STUDY OF WllON CARCINOGEN 1C ITY (BIOASSAY) OF VINYL TOLUENE IN B6C3F1 MICE.
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYL STYRENES PREPARED BY THE OFFICE °F HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC.

005566 FINAL CHRONIC REPORT PERFORMED FOR THE NTP UNDER CONTRACT NO N01-ES-38042
WASHINGTON. DC.

UCTUVI CTVDFMF Al PHA 000098-83-9
010016 WOLF MA ™ VK ROWE. DO MCCOLLISTER. ET AL. 1956 TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENES AND BENZENE. ARCH IND
HEALTH. 14: 387-398.

IIS FPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALPHA- METHYL STYRENE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRC^S A^SSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON. DC

UCTUVI cur RDOMTnr 000074-95-3
010011 KEYES DG JW HENCK GC JERSEY RJ KOCIBA DJ SCHWETZ AND TD LANDRY. 1982 METHYLENE BROMIDE: A 90-DAY REPEATED INHALATION
SKIT? STUDY IN RAT! ; i DOGS WITH A SUBSEQUENT TWO-YEAR HOLDING PERIOD FOR RATS TOXICOLOGY RESEARCH LAB. HEALTH AND
ENVIRONMENTAL SCIENCES. DOW CHEMICAL CO.. MIDLAND. MI.

IK FPA 19R7 HFAITH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYLENE BROMIDE PREPARED BY THE OFFICE OF HEALTH
m E™ENTA! ^SSES^MEN! ^EN™ENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC.
R2-4
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REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) May 19S5

NITROBENZENE 000098-95-3
010518 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1984. NINETY- DAY INHALATION STUDY OF NITROBENZENE IN F-344 RATS.CD RATS
AND B6C3F1 MICE WITH COVER LETTER DATED 6/24/84 AND EPA RESPONSE DATED 8/06/84. UNPUBLISHED STUDY FYI-OTS-0784-0333 AND
COMPUTER PRINT-OUT OF PATHOLOGY FINDING.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR NITROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
DC.

TRICHLOROFLUOROHETHANE 000075-69-4
005501 JENKINS. LJ. RA JONES. RA COON AND J SIEGAL. 1970. REPEATED AND CONTINUOUS EXPOSURES OF LABORATORY ANIMALS TO
TRICHLOROFLUORMETHANE. TOXICOL APPL PHARMACOL. 16. 133-142.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.
WASHINGTON. DC.
R2-5
-------
HEAST TABLE 3: CARCINOGENICITY
CHEMICAL ROUTE

ACEPHATE
EXPERIMENT LENGTH
SPECIES
TARGET

030560-19-1
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)-'
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Hay 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)-l
IRIS
010086
ACROLEIN
000107-02-8
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005001
ACRYLAMIDE
000079-06-1
ORAL- DRINKING
WATER
2 YEARS
RAT
IRIS
IRIS
4 5E+0
MAMMARY
THYROID
UTERUS
ORAL CAVITY
CENTRAL NERVOUS
SYSTEM
TUMORS
TUMORS
TUMORS
TUMORS
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
IRIS
010087
ACRYLONITRILE
000107-13-1
IRIS
IRIS
IRIS
005004
INHALATION:
OCCUPATIONAL
IRIS
2 4E-1
HUMAN LUNG TUMORS

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
IRIS
005003
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-1
-------
HEAST TABLE 3: CARCINOGENICITY
Hay 1995
CHEMICAL
ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
ALACHLOR
ALDRIN
015972-60-8
ORAL: DIET MULTIPLE SITES TUMORS B2 8E-2
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ORAL: DIET
000309-00-2

MOUSE LIVER
IRIS
IRIS
1 7E+1
CARCINOMA
2.3E-6
IRIS IRIS
010180
005006
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
INHALATION [UNIT RISK] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

ALLYL CHLORIDE 000107-05-1
IRIS 010181
GENERAL COMMENT: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC ASSESSMENT OF THIS
COMPOUND.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ANILINE 000062-53-3
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
010088
ARAMITE
ORAL: DIET
104 WKS
RAT
000140-57-8
LIVER
IRIS
IRIS
2 5E-2
TUMORS
IRIS
IRIS
010206
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-2
-------
HEAST TABLE 3: CARCINOGENICITY
CHEMICAL ROUTE

ARSENIC, INORGANIC
EXPERIMENT LENGTH
SPECIES
INHALATION:
OCCUPATIONAL
HUMAN
TARGET

007440-38-2
RESPIRATORY
SYSTEM
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
IRIS
5.0E+1
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ASBESTOS
001332-21-4
IRIS
IRIS
May 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L) l (ug/cu m)-l
IRIS
IRIS
010925

005007
IRIS
005010
005919
ATRAZINE
001912-24-9
ORAL: DIET
2 YEARS
RAT
MAMMARY GLAND
MAMMARY GLAND
MAMMARY GLAND
MAMMARY GLAND
ADENOMA
FIBROADENOMA
ADENOCARCINOMA
CARCINOSARCOMA
2 22E-1
ORAL [SLOPE] COMMENT: UNDER REVIEU. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
6.3E-6
010380
AZOBENZENE 000103-33-3
ORAL: DIET 2 YEARS
RAT
IRIS
IRIS
1.1E-1
ABDOMINAL CAVITY SARCOMA

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
IRIS
IRIS
010089
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-3
-------
HEAST TABLE 3: CARCINOGENICITY
May 1995
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
BENZENE
INHALATION:
OCCUPATIONAL
HUMAN
000071-43-2

BLOOD
CANCER
LEUKEMIA
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(mg/kg/day) '
IRIS IRIS
2 9E-2
ORAL [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
IRIS IRIS
005011
BENZIDINE 000092-87-5
IRIS IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS IRIS
005014
BENZOTRICHLORIDE

BENZO[A]ANTHRACENE
000098-07-7

000056-55-3
IRIS

IRIS
IRIS
IRIS
010092

010182
BENZO[A]PYRENE.
000050-32-8
IRIS IRIS
IRIS
010508
BENZO[B]FLUORANTHENE
000205-99-2
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010183
BENZO[K]FLUORANTHENE 000207-08-9
IRIS 010090
GENERAL COMMENT: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC ASSESSMENT OF THIS
COMPOUND.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254.
3-4
-------
CHEMICAL ROUTE

BENZYL CHLORIDE
HEAST TABLE 3: CARCINOGENICITY
EXPERIMENT LENGTH
SPECIES TARGET

000100-44-7
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
IRIS
IRIS
Hay 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)-l
IRIS
010093
BERYLLIUM 007440-41-7
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
INHALATION:
OCCUPATIONAL
IRIS
8.4E+0
HUMAN LUNG TUMORS

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
IRIS
IRIS
005018
005017
BIS(2-CHLOROETHYL) ETHER 000111-44-4
ORAL 560 DAYS
MOUSE LIVER
IRIS IRIS
1.1E+0
IRIS IRIS
TUMORS

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
BIS(2-CHLORO-1-METHYLETHYL) ETHER 000108-06-1
ORAL: GAVAGE 2 YEARS
MOUSE LIVER
LUNG
7E-2
3 5E-2
2E-6 1E-5
TUMORS
TUMORS
005076
005079
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION (50% RESPIRATORY ABSORPTION) SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: COMPOUND TESTED CONTAINED 70* BIS(2-CHLORO-1-METHYLETHYL)£THER AND 30* BIS(2-CHLOROISOPROPYL)ETHER. ALSO SEE HEAST TABLE 1:
SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
BIS(2-ETHYLHEXYL) PHTHALATE / (DEHP) 000117-81-7
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
005120
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE: (513) 569-7254.
3-5
-------
HEAST TABLE 3: CARCINOGENICITY
Nay 1995
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
BIS(CHLOROMETHYL) ETHER 000542-88-1
INHALATION: 10-100 DAYS
INTERMITTENT RAT RESPIRATORY
SYSTEM
CANCER
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) Hmg/kg/day)'1
IRIS
IRIS
2.2E+2
ORAL [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.

BROMODICHLOROMETHANE 000075-27-4
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
BROMOETHENE / (VINYL BROMIDE) 000593-60-2
INHALATION: 2 YEARS
INTERMITTENT RAT LIVER
B2
1 1E-1
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
BROHOFORH
000075-25-2
ORAL: GAVAGE
2 YEARS
RAT
IRIS
INTESTINE. LARGE ADENOMATOUS POLYP
ADENOCARCINOMA
IRIS
3 9E-3
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cum)-l
IRIS
IRIS
005077
IRIS
3.2E-5
005148
010094
IRIS
IRIS
005150
INHALATION [SLOPE] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
BUTADIENE. 1.3-
INHALATION:
INTERMITTENT
IRIS
000106-99-0

MOUSE MULTIPLE SITES TUMORS

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
1 8E+0
IRIS
010477
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-6
-------
CHEMICAL ROUTE

BUTYL BENZYL PHTHALATE. N-
EXPERIMENT LENGTH
SPECIES
TARGET

000085-68-7
CADMIUM
HEAST TABLE 3: CARCINOGENICITY

[SLOPE FACTOR]
[EPA ORAL INHALATION
CANCER GROUP] (mg/kg/day) '(mg/kg/day)'
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
007440-43-9
IRIS
May 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)-l
005122
ORAL [SLOPE] COMMENT: THERE IS INADEQUATE EVIDENCE FOR THE CARCINOGENICITY OF THIS COMPOUND BY THE ORAL ROUTE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
005019
CAPTAFOL
CAPTAN
002425-06-1
ORAL: DIET
8 6E-3
MOUSE
LYMPHATIC SYSTEM LYMPHOSARCOMA
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000133-06-2
B2
3.5E-3
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CARBAZOLE
ORAL: DIET
96 WEEKS
MOUSE
000086-74-8
LIVER
B2
2E-2
TUMORS
2 4E-7
1 OE-7
5.7E-7
010095
010184
010096
CARBON TETRACHLORIDE
ORAL: DIET
000056-23-5
LIVER
TUMORS
IRIS
IRIS
5.3E-2
IRIS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST
INHALATION [UNIT RISK] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. INCORPORATES AN ABSORPTION FACTOR OF 0.4
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
005022
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-7
-------
HEAST TABLE 3: CARCINOGENICITY
May 1995
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
[UNIT RISK]
ORAL INHALATION
(ug/L)"' (ug/cu m)-l
REFERENCE
CHLORANIL
ORAL: DIET
82 WEEKS
MOUSE
000118-75-2

LIVER
LUNG
TUMORS
TUMORS
4 03E-1
1 2E-5
010097
CHLORDANE
ORAL: DIET
000057-74-9

MOUSE LIVER
IRIS
IRIS
1 3E+0
IRIS
CARCINOMA
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLORO-2-METHYLANILINE HYDROCHLORIDE. 4-
ORAL:'DIET 18 MONTHS
003165-93-3
B2
4.6E-1
1 3E-5
MOUSE
CHLORO-2-METHYLANILINE. 4-
ORAL: DIET 18 MONTHS
MOUSE
CARDIOVASCULAR HEMANGIOMA
SYSTEM
CARDIOVASCULAR HEMANGIOSARCOMA
SYSTEM

000095-69-2
82
5 8E-1
1 6E-5
CARDIOVASCULAR HEMANGIOMA
SYSTEM
CARDIOVASCULAR HEMANGIOSARCOMA
SYSTEM

ORAL [SLOPE] COMMENT: BASED ON VASCULAR TUMORS IN MICE TREATED WITH 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE
IRIS
005024
010419
010098
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
3-8
-------
HEAST TABLE 3: CARCINOGENICITY May 1995

[SLOPE FACTOR] [UNIT RISK]
EXPERIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/day) '(mg/kg/day) ' (ug/L)'1 (ug/cu m)-l

CHLOROBENZILATE 000510-15-6
ORAL: GAVAGE. 82 WEEKS B2 2 7E-1 2 7E-1 7 8E-6 7.8E-5 010848
DIET ' MOUSE LIVER HEPATOMA

INHALATION [SLOPE] COMMENT: ABSORBANCE BY THE INHALATION ROUTE WAS ASSUMED TO EQUAL ORAL ABSORPTION SINCE THERE WERE NO
PHARMACOKINETIC DATA TO THE CONTRARY. SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
INHALATION [UNIT RISK] COMMENT: ABSORBANCE BY THE INHALATION ROUTE WAS ASSUMED TO EQUAL ORAL ABSORPTION SINCE THERE WERE NO
PHARMACOKINETIC DATA TO THE CONTRARY.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

CHLOROFORM 000067-66-3
IRIS IRIS IRIS 005036

ORAL: GAVAGE 78 WEEKS IRIS 8 1E-2 IRIS 005035
MOUSE LIVER CARCINOMA

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

CHLOROMETHANE 000074-87-3
INHALATION: 24 MONTHS C 1 3E-2 6 3E-3 3 7E-7 1 8E-6 005038
INTERMITTENT MOUSE KIDNEY TUMORS

ORAL [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENCIITY)

CHLOROMETHYL METHYL ETHER 000107-30-2
IRIS 005081
GENERAL COMMENT: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED
NUMERIC ASSESSMENT OF THIS COMPOUND.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE- (513) 569-7254. 3-9
-------
HEAST TABLE 3: CARCINOGENICITY
Hay 1995
EXPERIMENT LENGTH
CHEMICAL ROUTE SPECIES
CHLORONITROBENZENE. 0-
ORAL: DIET 18 MONTHS
MOUSE
TARGET

000088-73-3

LIVER
CANCER
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (ing/kg/day) '(ing/kg/day)'
B2 2.5E-2
[UNIT RISK]
ORAL INHALATION
(ug/L)' (ug/cu m)-l
REFERENCE
7.1E-7
010099
CHLORONITROBENZENE. P-
ORAL: DIET
000100-00-5
18 MONTHS
MOUSE
CARDIOVASCULAR
SYSTEM
TUMORS
B2
1.8E-2
5.1E-7
010100
CHLOROTHALONIL
ORAL: DIET
001897-45-6
27-32 MONTHS
RAT KIDNEY
TUMOR
B2
1.1E-2
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHROMIUH(VI)
INHALATION:
OCCUPATIONAL
HUMAN
018540-29-9

LUNG
IRIS
4.1E+1
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
3.1E-7
IRIS
010384
005091
CHRYSENE
000218-01-9
IRIS
GENERAL COMMENT: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010185
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-10
-------
HEAST TABLE 3: CARCINOGENICITY
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
COKE OVEN EMISSIONS
INHALATION:
OCCUPATIONAL HUMAN
TARGET

008007-45-2

LUNG
CANCER
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) Hmg/kg/day)'1
IRIS
2.2E+0
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
GENERAL COMMENT: FORMERLY LISTED UNDER COAL TARS.
Hay 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)-l
IRIS
005039
CREOSOTE. COAL TAR
008001-58-9
IRIS
005042
CRESOL. M- / (3-METHYLPHENOL) 000108-39-4
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010187
CRESOL. 0- / (2-METHYLPHENOL) 000095-48-7
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010186
CRESOL. P- / (4-METHYLPHENOL) 000106-44-5
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CROTONALDEHYDE 000123-73-9
ORAL: DRINKING 113 WKS
WATER RAT LIVER
IRIS
1 9E+0
TUMOR
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
5.4E-5
010188
010190
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-11
-------
HEAST TABLE 3: CARCINOGENICITY
Nay 1995
CHEMICAL ROUTE

CYANAZINE
EXPERIMENT LENGTH
SPECIES
ORAL: DIET
2 YEARS
RAT
TARGET

021725-46-2

MAMMARY GLAND
CANCER
ADENOMA/
CARCINOMA.
COMBINED
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-'
8.4E-1
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cumM
2.4E-5
010944
ODD
000072-54-8
IRIS
IRIS
IRIS
010291
DDE
000072-55-9
IRIS IRIS
IRIS
010292
DDT
ORAL: DIET
000050-29-3

MOUSE, RAT LIVER
IRIS IRIS
3 4E-1
TUMORS
IRIS IRIS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
005044
DECABROMODIPHENYL ETHER
001163-19-5
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010102
DIALLATE
002303-16-4
ORAL
19 MONTHS
MOUSE
B2
6 1E-2
LIVER
1 7E-6
TUMORS
010103
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254
3-12
-------
HEAST TABLE 3: CARCINOGEN1CITY
Hay 1995
CHEMICAL ROUTE

DIBENZO[A.H]ANTHRACENE
EXPERIMENT LENGTH
SPECIES TARGET
[SLOPE FACTOR] [UNIT RISK]
[EPA ORAL INHALATION ORAL INHALATION REFERENCE
CANCER GROUP] (mg/kg/day) '(mg/kg/day)' (ug/L)'1 (ug/cu m)-l
000053-70-3
IRIS 010191
GENERAL COMMENT: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED
NUMERIC ASSESSMENT OF THIS COMPOUND.
DIBROMO-3-CHLOROPROPANE, 1.2 000096-12-8
ORAL: DIET B2 1 4E+0 4E-5 010484
STOMACH TUMORS
KIDNEY TUMORS
LIVER TUMORS

[EPA GROUP] COMMENT: UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
INHALATION:
INTERMITTENT
B2
2 4E-3
6.9E-7
RAT. MOUSE
NASAL CAVITY
TUMORS
010519
DIBROHOCHLOROMETHANE 000124-48-1
IRIS IRIS IRIS
GENERAL COMMENT: FORMERLY LISTED AS CHLORODIBROMOMETHANE. ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY).
010891
DIBROMOETHANE. 1.2- 000106-93-4

GENERAL COMMENT: FORMERLY LISTED UNDER ETHYLENE DIBROMIDE
IRIS
IRIS
IRIS
005818
INHALATION:
INTERMITTENT
88-103 WEEKS
RAT
IRIS
7 6E-1
IRIS
NASAL CAVITY
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005071
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-13
-------
HEAST TABLE 3: CARCINOGENICITY
Nay 1995
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
DICHLORO-2-BUTENE. 1.4-
INHALATION: 90 DAYS
INTERMITTENT RAT
TARGET CANCER

000764-41-0

NASAL PASSAGES TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'
82
9.3E+0
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: FORMERLY LISTED UNDER DICHLOROBUTENES
DICHLOROBENZENE. 1.4- 000106-46-7
ORAL: GAVAGE 103 WEEKS
MOUSE LIVER
2.4E-2
TUMORS
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
2.6E-3
005053
6.8E-7
005050
DICHLOROBENZIDINE. 3.3'-
000091-94-1
IRIS
IRIS
IRIS
005815
DICHLOROETHANE. 1.1-
000075-34-3
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005055
DICHLOROETHANE. 1.2-
ORAL: GAVAGE
000107-06-2
78 WEEKS
RAT
IRIS
IRIS
9.1E-2
CIRCULATORY
SYSTEM
SARCOMA
IRIS
IRIS
005058
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-14
-------
HEAST TABLE 3: CARCINOGENICITY May 1995

[SLOPE FACTOR] [UNIT RISK]
EXPERIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/day) Hmg/kg/day)' (ug/L) ' (ug/cu m)-l

DICHLOROETHYLENE. 1.1- 000075-35-4
IRIS IRIS IRIS 005060

INHALATION 12 MONTHS IRIS 1 2E+0 IRIS 005059
MOUSE KIDNEY ADENOCARCINOMA

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

DICHLOROPROPANE. 1.2- 000078-87-5
ORAL: GAVAGE B2 6.8E-2 1.9E-6 005062
MOUSE LIVER TUMORS

ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UP047FO MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254. 3-15
-------
HEAST TABLE 3: CARCINOGEN1CITY
Nay 1995
EXPERIMENT LENGTH
CHEMICAL ROUTE

DICHLOROPROPENE. 1.3
ORAL: GAVAGE
DIELDRIN
ORAL: GAVAGE
SPECIES
/ (TELONE II)
104 WEEKS
MOUSE

104 WEEKS
RAT
TARGET
000542-75-6

BLADDER
RESPIRATORY
SYSTEM

FORESTOMACH

LIVER
CANCER

CARCINOMA
ALVEOLAR/
BRONCHIOLAR
ADENOMA
PAPILLOMA/
CARCINOMA

NEOPLASTIC
GRI

IRIS

NODULE/CARCINOMA

FORESTOMACH

PAPILLOMA/
CARCINOMA

[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)-1
1 8E-1
ORAL [SLOPE] COMMENT: THE [SLOPE] IS THE GEOMETRIC MEAN OF SLOPE FACTORS OF COMBINED TUMORS LISTED.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
INHALATION:
INTERMITTENT
2 YEARS
MOUSE
IRIS
1.3E-1
LUNG
ADENOMA
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ORAL: DIET
000060-57-1

MOUSE LIVER
IRIS
IRIS
1.6E+1
CARCINOMA
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
INHALATION [UNIT RISK] COMMENT: BASED ON ROUTE-TO-ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)-l
5E-6
010946
3.7E-5
010104
IRIS
IRIS
005816
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
3-16
-------
HEAST TABLE 3: CARCINOGENICITY
CHEMICAL ROUTE

DIETHYLSTILBESTROL
ORAL: DIET
EXPERIMENT LENGTH
SPECIES TARGET CANCER

000056-53-1

MOUSE MAMMARY GLAND CARCINOMA
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'
4 7E+3
Hay 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
1.3E-1
010485
DIMETHOXYBENZIDINE. 3.3'- 000119-90-4
ORAL: DIET LIFETIME
HAMSTER FORESTOMACH
82
PAPILLOMA
1.4E-2
4E-7
010106
DIMETHYLANILINE HYDROCHLORIDE. 2.4- 021436-96-4
ORAL: DIET 18 MONTHS
MOUSE LUNG
TUMORS
5.8E-1
1.7E-5
010108
DIMETHYLANILINE. 2.4- 000095-68-1
ORAL: DIET 18 MONTHS
MOUSE LUNG
TUMORS
7 5E-1
2.1E-5
010107
DIMETHYLBENZIDINE. 3.31- 000119-93-7
ORAL: GAVAGE 30 DAYS
RAT MAMMARY
TUMORS
B2
9 2E+0
2.6E-4
010109
DIMETHYLBENZ[A]ANTHRACENE. 7.12- 000057-97-6

GENERAL COMMENT: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED
NUMERIC ASSESSMENT OF THIS COMPOUND.
010297
DIMETHYLHYDRAZINE. 1.1- 000057-14-7
GENERAL COMMENT: NO EPA GROUP CLASSIFICATION WAS PROVIDED IN THE REFERENCE DOCUMENT. THEREFORE THIS COMPOUND WAS
REMOVED FROM TABLE 3.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-17
-------
HEAST TABLE 3: CARCINOGEN1CITY
Nay 1995
CHEMICAL ROUTE

DIMETHYLHYDRAZINE. 1.2-

DIMETHYLSULFATE
EXPERIMENT LENGTH
SPECIES
TARGET

000540-73-8

000077-78-1
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(nig/kg/day)'
B2
IRIS
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)-l
010962
010112
DINITROTOLUENE. 2.4- 000121-14-2
IRIS IRIS IRIS
GENERAL COMMENT: LISTED AS "DINITROTOLUENE MIXTURE. 2.4-72.6-" ON IRIS. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY).
005066
DINITROTOLUENE. 2.6- 000606-20-2
IRIS IRIS IRIS
GENERAL COMMENT: LISTED AS "DINITROTOLUENE MIXTURE. 2.4-/2.6-" ON IRIS. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY).
005068
DIOXANE. 1.4-
000123-91-1
IRIS
IRIS
IRIS
010298
DIPHENYLHYDRAZINE. 1.2- 000122-66-7
ORAL: DIET 2 YEARS
RAT LIVER
IRIS IRIS
8.0E-1
IRIS IRIS
TUMORS

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
005070
DIRECT BLACK 38
ORAL: DIET
001937-37-7
93 DAYS
RAT
8 6E+0
2.4E-4
LIVER TUMORS

ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
010113
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-18
-------
HEAST TABLE 3: CARCINOGEN1CITY
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
CANCER
DIRECT BLUE 6
ORAL: DIET
DIRECT BROWN 95
ORAL: DIET
TARGET

002602-46-2

LIVER TUMORS

ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.

016071-86-6

LIVER TUMORS

ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
91 DAYS
RAT
91 DAYS
RAT
[SLOPE FACTOR]
[EPA ORAL INHALATION
G'ROUP] (mg/kg/day) '(mg/kg/day)'1
8.1E+0
9.3E+0
May 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)•' (ug/cu m)-l
2.3E-4
2.6E-4
010114
010115
DIRECT SKY BLUE 6B
002610-05-1
82
[EPA GROUP] COMMENT: BASED ON THE FACT THAT 3.3-DIMETHOXYBENZIDINE. A KNOWN EPA GROUP B2 CARCINOGEN. IS A METABOLITE
OF DIRECT SKY BLUE 6B.
EPICHLOROHYDRIN
INHALATION:
INTERMITTENT
000106-89-8
30 DAYS.
OBSERVED LIFETIME
RAT NASAL CAVITY
IRIS

IRIS
IRIS
IRIS
4 2E-3
IRIS
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010116
010198

010117
ETHYL ACRYLATE
ORAL: GAVAGE
000140-88-5
104 WEEKS
RAT
B2
4.8E-2
FORESTOMACH
1.4E-6
TUMORS
010118
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-19
-------
HEAST TABLE 3: CARCINOGENICITY
Hay 1995
CHEMICAL ROUTE

ETHYLENE OXIDE
ORAL: GAVAGE
EXPERIMENT LENGTH
SPECIES
TARGET
[SLOPE FACTOR]
[EPA ORAL INHALATION
CANCER GROUP] (mg/kg/day) Hmg/kg/day)'
000075-21-8
LIFETIME. TWICE WEEKLY
RAT STOMACH
TUMORS

ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
INHALATION:
INTERMITTENT
2 YEARS
RAT
BLOOD
BRAIN
LEUKEMIA
GLIOMA
Bl 1 02E+0
Bl 3.5E-1
ETHYLENE THIOUREA
ORAL: GAVAGE
INHALATION [UNIT RISK] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.

000096-45-7
2 YEARS
MOUSE
LIVER
B2
ADENOMA/
CARCINOMA, COMBINED
1.1E-1
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
2.9E-5
1E-4
3.4E-6
010421
010422
010947
FOLPET 000133-07-3
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
010120
FORMALDEHYDE
INHALATION
000050-00-0
24 MONTHS
RAT
IRIS
4 5E-2
NASAL CAVITY
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
010121
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
3-20
-------
HEAST TABLE 3: CARCINOGEN1CITY
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
FURAZOLIDONE
ORAL: DIET
45 WEEKS
RAT
CANCER
TARGET

000067-45-8

MAMMARY TUMORS

GENERAL COMMENT: FORMERLY LISTED UNDER NITROFURANS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'
B2 3 8E+0
Hay 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L) ' (ug/cu m)-l
1E-4
005106
FURIUM
000531-82-8
ORAL: DIET
28 WEEKS
MOUSE
BLOOD

GENERAL COMMENT: FORMERLY LISTED UNDER NITROFURANS
LEUKEMIA
B2
5 OE+1
1.4E-3
005108
6LYCIDALDEHYDE
000765-34-4
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
HEPTACHLOR
ORAL: DIET
000076-44-8

MOUSE LIVER
IRIS
IRIS
4 5E+0
CARCINOMA
IRIS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
HEPTACHLOR EPOXIDE
ORAL: DIET
001024-57-3
18-24 MONTHS
MOUSE LIVER
IRIS
IRIS
9 1E+0
IRIS
CARCINOMA
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
IRIS
010122
005820
010424
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE: (513) 569-7254.
3-21
-------
HEAST TABLE 3: CARCINOGEN1CITY
Hay 1995
CHEMICAL ROUTE

HEXACHLOROBENZENE
ORAL: DIET
EXPERIMENT LENGTH
SPECIES
RAT
TARGET

000118-74-1

LIVER
CANCER
TUMORS
[SLOPE FACTOR] [UNIT RISK]
[EPA ORAL INHALATION ORAL INHALATION REFERENCE
GROUP] (mg/kg/day) '(mg/kg/day) ' (ug/L) > (ug/cu m)-l
IRIS
IRIS
1 6E+0
IRIS
INHALATION [SLOPE] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
010365
HEXACHLOROBUTAOIENE 000087-68-3
ORAL: DIET 22-24 MONTHS
RAT KIDNEY
IRIS IRIS
7 8E-2
IRIS
TUMORS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
HEXACHLOROCYCLOHEXANE. ALPHA- 000319-84-6
ORAL: DIET 24 WEEKS
MOUSE LIVER
IRIS
IRIS
6.3E+0
IRIS
TUMORS

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
HEXACHLOROCYCLOHEXANE. BETA- 000319-85-7
ORAL: DIET 110 WEEKS
MOUSE LIVER
IRIS
IRIS
1 8E+0
IRIS
TUMORS

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
IRIS
IRIS
IRIS
005088
010123
010124
HEXACHLOROCYCLOHEXANE. DELTA- 000319-86-8
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010125
IRIS
HEXACHLOROCYCLOHEXANE. EPSILON- 006108-10-7

GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE (513) 569-7254.
010126
3-22
-------
HEAST TABLE 3: CARCINOGENICITY
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(ing/kg/day)'1
May 1995
[UNIT RISK]
ORAL INHALATION
(ug/L) ' (ug/cu m)-l
REFERENCE
HEXACHLOROCYCLOHEXANE, GAMMA- 000058-89-9
ORAL: DIET 110 WEEKS
MOUSE LIVER
B2-C
1 3E+0
TUMORS
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
3.7E-5
005098
HEXACHLOROCYCLOHEXANE-TECHNICAL 000608-73-1
ORAL: DIET 6-20 MONTHS
MOUSE LIVER
IRIS IRIS
1.8E+0
IRIS IRIS
TUMORS

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
010127
HEXACHLOROETHANE 000067-72-1
ORAL: GAVAGE 78 WEEKS
MOUSE LIVER
IRIS
IRIS
1 4E-2
IRIS
CARCINOMA
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
HYDRAZINE
000302-01-2
INHALATION: 1 YEAR
INTERMITTENT RAT
IRIS

IRIS
IRIS
IRIS
1 7E+1
NASAL CAVITY TUMORS

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
IRIS
IRIS
005090
010129

010128
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-23
-------
CHEMICAL ROUTE

HYDRAZINE SULFATE
EXPERIMENT LENGTH
SPECIES TARGET

010034-93-2
HEAST TABLE 3: CARCINOGENICITY

[SLOPE FACTOR]
[EPA ORAL INHALATION
CANCER GROUP] (mg/kg/day) '(mg/kg/day)'1
INHALATION: 1 YEAR
INTERMITTENT RAT
IRIS IRIS

IRIS
1 7E+1
NASAL CAVITY TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: LISTED UNDER "HYDRAZINE" ON IRIS.
Hay 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)-l
IRIS
IRIS
010131

010130
INDENO[1.2.3-CD]PYRENE
000193-39-5
IRIS
010192
ISOPHORONE 000078-59-1

GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005094
LEAD
007439-92-1
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005096
LINURON
000330-55-2
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010383
MERCURIC CHLORIDE
007487-94-7
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010971
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-24
-------
HEAST TABLE 3: CARCINOGEN1CITY May 1995

[SLOPE FACTOR] [UNIT RISK]
EXPERIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/day) '(mg/kg/day)'1 (ug/L)'1 (ug/cu m)-l

MERCURY. ELEMENTAL 007439-97-6
IRIS 010973
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN ICITY).

METHOXY-5-NITROANILINE. 2- 000099-59-2
ORAL: DIET 104 WEEKS B2 4 6E-2 1 3E-6 010132
RAT SKIN CARCINOMA

METHYLHYDRAZINE 000060-34-4
GENERAL COMMENT: NO EPA GROUP CLASSIFICATION WAS PROVIDED IN THE REFERENCE DOCUMENT. THEREFORE THIS COMPOUND WAS REMOVED FROM TABLE 3.

METHYL-5-NITROANILINE. 2- 000099-55-8
ORAL: DIET 98 WEEKS C 3.3E-2 9 4E-7 010140
MOUSE LIVER CARCINOMA

METHYLANILINE HYDROCHLORIDE. 2- 000636-21-5
ORAL: DIET 93 WEEKS B2 1.8E-1 5 1E-6 010134
RAT SKIN FIBROMA

METHYLANILINE. 2- 000095-53-4
ORAL: DIET 93 WEEKS B2 2.4E-1 6 9E-6 010133
RAT SKIN FIBROMA

GENERAL COMMENT: THE 1984 HEEP CALLED THIS COMPOUND 0-TOLUIDINE. THE 1987 HEEP CALLED IT 2-METHYLANILINE.

METHYLCHOLANTHRACENE. 3- 000056-49-5
010299
GENERAL COMMENT: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED
NUMERIC ASSESSMENT OF THIS COMPOUND

IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254. 3-25
-------
HEAST TABLE 3: CARCINOGENICITY Hay 1995

[SLOPE FACTOR] [UNIT RISK]
FXPFRIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/day) "(mg/kg/day)' (ug/L)'1 (ug/cu m)-l

METHYLENE CHLORIDE / (DICHLOROMETHANE) 000075-09-2
IRIS IRIS IRIS 005100
IRIS IRIS 005904

GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

METHYLENE-BIS(BENZENEAMINE). 4.4- / (4.4'-METHYLENEDIANILINE) 000101-77-9
GENERAL COMMENT: NO EPA GROUP CLASSIFICATION WAS PROVIDED IN THE REFERENCE DOCUMENT. THEREFORE THIS COMPOUND WAS REMOVED FROM TABLE 3.

METHYLENE-BISC2-CHLOROANILINE). 4.41- 000101-14-4
ORAL- DIET 2 YEARS B2 1.3E-1 1.3E-1 3.7E-6 3.7E-5 010425
RAT LUNG TUMORS

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST BASED ON ROUTE TO ROUTE EXTRAPOLATION.

METHYLENE-BIS(N.N'-DIMETHYL)ANILINE. 4.41- 000101-61-1
IRIS IRIS IRIS 010137
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

METHYLMERCURY 0022967-92-6
IRIS 010972
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

METOLACHLOR 051218-45-2
IRIS 010951

002385-85-5
ORAL: DIET 2 YEARS B2
RAT LIVER ADENOMA
LIVER CARCINOMA

[EPA GROUP] COMMENT: UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 3-26
-------
HEAST TABLE 3: CARCINOGENICITY Hay 1995

[SLOPE FACTOR] [UNIT RISK]
EXPERIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/day) '(mg/kg/day)' (ug/L)' (ug/cu m)-l

NIAGARA BLUE 48 002429-74-5
B2 010141

[EPA GROUP] COMMENT: BASED ON THE FACT THAT 3.3-DIMETHOXYBENZIDINE. A KNOWN EPA GROUP B2 CARCINOGEN IS A
METABOLITE OF NIAGARA BLUE 4B.

NICKEL REFINERY DUST
INHALATION: IRIS 8.4E-1 IRIS 005103
OCCUPATIONAL HUMAN RESPIRATORY TUMORS
SYSTEM

NICKEL SUBSULFIDE 012035-72-2
INHALATION: IRIS l 7E+0 IRIS 005768
OCCUPATIONAL HUMAN RESPIRATORY TUMORS
SYSTEM

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: FORMERLY LISTED AS NICKEL. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (UNDER NICKEL).
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 3-27
-------
HEAST TABLE 3: CARCINOGENICITY
Hay 1995
EXPERIMENT LENGTH
CHEMICAL ROUTE

NITROBENZENE
INHALATION
INHALATION
SPECIES

2 YEAR
MICE

2 YEAR
RAT

TARGET
000098-95-3

LUNG
LUNG
THYROID
MAMMARY

LIVER
LIVER
KIDNEY
KIDNEY
UTERUS
CANCER GROUI

B2
ADENOMA
CARCINOMA
ADENOMA
ADENOCARCINOMA

ADENOMA
CARCINOMA
ADENOMA
ADENOCARCINOMA
ENDIOMETRIAL POLYPS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-'
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
010969
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
NITROFURAZONE
ORAL: DIET
46 WEEKS
RAT
000059-87-0
MAMMARY
B2
TUMORS
1 5E+0
4.3E-5
005110
NITROPROPANE. 2- 000079-46-9
INHALATION: 22 MONTHS
INTERMITTENT RAT LIVER
B2
TUMORS

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
NITROSO-DI-N-BUTYLAMINE. N- 000924-16-3
ORAL: DRINKING LIFETIME
WATER MOUSE BLADDER
ESOPHAGUS
IRIS IRIS
TUMORS
TUMORS
9 4E+0
5 4E+0
2 7E-3
IRIS
IRIS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
010142
010143
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-28
-------
HEAST TABLE 3: CARCINOGENICITY
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
May 1995
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'
[UNIT RISK]
ORAL INHALATION
(ug/L)' (ug/cu m)-l
REFERENCE
NITROSO-DI-N-PROPYLAMINE. N- 000621-64-7
IRIS
IRIS
IRIS
010147
NITROSO-N-ETHYLUREA. N- 000759-73-9
ORAL: DRINKING 203 DAYS
WATER RAT INTESTINE
B2
GASTROINTESTINAL
TUMORS
1 4E+2
[EPA GROUP] COMMENT: UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
GENERAL COMMENT: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 382-4761 FOR RCRA-APPROVED
NUMERIC ASSESSMENT FOR THIS COMPOUND. UNDER REVIEW.
NITROSO-N-METHYLUREA. N- 000684-93-5
ORAL: GAVAGE 308 DAYS
GUINEA PIG PANCREAS
B2
ADENOCARCINOMA
[EPA GROUP] COMMENT: UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
GENERAL COMMENT: THE CRAVE WORK GROUP (04/01/92) STATES THERE IS NO ACCEPTABLE QUANTITATION FOR NITROSO-N-METHYLUREA. N-
010426
010427
NITROSODIETHANOLAMINE. N-
001116-54-7
NITROSODIETHYLAMINE, N- 000055-18-5
ORAL: DRINKING 6 OR 12 MONTHS
WATER RAT LIVER
IRIS
IRIS
IRIS
IRIS
1 5E+2
IRIS
IRIS
IRIS
TUMORS

INHALATION [SLOPE]-COMMENT; BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.

000062-75-9
NITROSODIMETHYLAMINE. N-
ORAL: DRINKING
WATER RAT LIVER TUMORS
IRIS
IRIS
5.1E+1
IRIS
IRIS
010144
010145
010146
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-29
-------
HEAST TABLE 3: CARCINOGEN1CITY
Hay 1995
CHEMICAL
EXPERIMENT LENGTH
SPECIES
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
ROUTE SPECIES TARGET CANCER

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
NITROSODIPHENYLAMINE. N-
000086-30-6
IRIS
IRIS
IRIS
005112
NITROSOMETHYLETHYLAMINE, N- 010595-95-6
IRIS IRIS
IRIS
010148
NITROSOMETHYLVINYLAMINE, N
INHALATION
RAT
ORAL: DRINKING
WATER
004549-40-0
82
UPPER RESPIRATORY CARCINOMAS
TRACT
UPPER DIGESTIVE CARCINOMAS
TRACT
010149
NITROSOPYRROLIDINE. N- 000930-55-2
ORAL: DIET LIFETIME
RAT LIVER
IRIS IRIS
TUMORS
2 1E+0
IRIS IRIS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
PARATHION
000056-38-2
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXIC1TY (OTHER THAN CARCINOGENICITY)
010300
005116
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
3-30
-------
HEAST TABLE 3: CARCINOGENICITY
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET CANCER

000087-84-3
PENTABROMO-6-CHLOROCYCLOHEXANE. 1.2.3.4.5-
ORAL: DIET 2 YEARS
RAT INTESTINE. LARGE TUMORS

ORAL [SLOPE] COMMENT: BASED ON RESULTS WITH THE ALPHA ISOMER.
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)-'
2.3E-2
May 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
6.6E-7
010150
PENTACHLORONITROBENZENE 000082-68-8
ORAL 72 WEEKS
MOUSE LIVER
TUMORS
2 6E-1
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
7.4E-6
010151
PENTACHLOROPHENOL 000087-86-5
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
010381
PHENYLENEDIAMINE. 0-
ORAL: DIET
548 DAYS
RAT
000095-54-5
LIVER
82
4.7E-2
TUMORS
ORAL [SLOPE] COMMENT: BASED ON LIVER TUMORS IN RATS TREATED WITH 0-PHENYLENEDIAMINE DIHYDROCHLORIDE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
1 3E-6
010152
PHENYLPHENOL. 2-
ORAL: DIET
000090-43-7
637 DAYS
RAT
1 94E-3
URINARY BLADDER TUMORS
5.5E-8
010153
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-31
-------
HEAST TABLE 3: CARCINOGEN1CITY
Hay 1995
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
POLYBROMINATED BIPHENYLS
ORAL: GAVAGE 25 WEEKS
RAT
TARGET
LIVER
LIVER
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) Hmg/kg/day)'
B2
CARCINOMA
NEOPLASTIC NODULE
8.9E+0
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
POLYCHLORINATED BIPHENYLS

PROPYLENE OXIDE
001336-36-3

000075-56-9
INHALATION:
INTERMITTENT
2 YEARS
MOUSE
IRIS

IRIS

IRIS
IRIS
IRIS
1 3E-2
NASAL CAVITY
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' " (ug/cu m)-l
2.5E-4
IRIS
IRIS
IRIS
010154
005118

010156

010155
QUINOLINE 000091-22-5
ORAL: DIET 20-40 WEEKS
RAT LIVER
1.2E+1
TUMORS
3.5E-4
010158
RDX / (CYCLONITE) 000121-82-4
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
010157
SELENIUM SULFIDE
007446-34-6
IRIS
ORAL [SLOPE] COMMENT: STUDY RESULTS WERE CONSIDERED INCONCLUSIVE FOR QUANTITATIVE RISK ASSESSMENT.
010194
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-32
-------
CHEMICAL

SIHAZINE
HEAST TABLE 3: CARCINOGEN1CITY
ROUTE
ORAL: DIET
EXPERIMENT LENGTH
SPECIES
2 YEARS
RAT
TARGET

000122-34-9

MAMMARY
CANCER
CARCINOMA
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day) >
1.2E-1
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
Hay 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
3.4E-6
010195
SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
ORAL: DIET 77 WEEKS
MOUSE LIVER
2 7E-1
TUMORS

GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
7.7E-6
005126
STYRENE 000100-42-5

GENERAL COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TCDD. 2.3.7.8-
ORAL: DIET
001746-01-6
720 DAYS

RAT
B2
1 5E+5
1.5E+5
RESPIRATORY
SYSTEM
LIVER
TUMORS

TUMORS
4.5E+0
3 3E-5
(PG/CU M)-l
010480
005128
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST
INHALATION [UNIT RISK] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE BASED ON ROUTE TO ROUTE EXTRAPOLATION.
AN ABSORPTION FACTOR OF 75* IS USED TO CALCULATE THE UNIT RISK FROM THE SLOPE FACTOR.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK. INFORMATION HOTLINE: (513) 569-7254.
3-33
-------
HEAST TABLE 3: CARCINOGENICITY
Hay 1995
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
[SLOPE FACTOR] [UNIT RISK]
[EPA ORAL INHALATION ORAL INHALATION REFERENCE
GROUP] (mg/kg/day) Hmg/kg/day)' (ug/L)' (ug/cu m)-l
TARGET CANCER

000630-20-6

LIVER TUMOR

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
TETRACHLOROETHANE. 1.1.1.2-
ORAL: GAVAGE 103 WEEKS
IRIS
IRIS
2.6E-2
IRIS
IRIS
010302
TETRACHLOROETHANE. 1.1.2.2- 000079-34-5
ORAL: GAVAGE 75 WEEKS
MOUSE LIVER
IRIS
IRIS
2 OE-1
IRIS
CARCINOMA

INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
IRIS
005130
TETRACHLOROETHYLENE
000127-18-4
GENERAL COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010482
TETRACHLOROTOLUENE. PARA. ALPHA. ALPHA. ALPHA-
ORAL: GAVAGE 17.5 WEEKS
MOUSE LUNG
005216-25-1
B2 2 OE+1
ADENOCARCINOMA
5.7E-4
005028
TETRACHLOROVINPHOS / (STIROFOS) 000961-11-5
ORAL: DIET 560 DAYS
MOUSE LIVER
TUMORS
2 4E-2
[EPA GROUP] COMMENT: UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TOLUENE-2.4-DIAMINE
ORAL: DIET
000095-80-7
84-103 WEEKS
RAT MAMMARY
B2
3 2E+0
TUMORS
6.9E-7
9.1E-5
010159
010160
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254.
3-34
-------
HEAST TABLE 3: CARCINOGENICITY
CHEMICAL ROUTE

TOLUIDINE. P-
ORAL: DIET
EXPERIMENT LENGTH
SPECIES
18 MONTHS
MOUSE
TARGET

000106-49-0

LIVER
CANCER
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) Hmg/kg/day)'1
1.9E-1
Nay 1995

[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)-l
5.4E-6
010162
TOXAPHENE
008001-35-2
ORAL: DIET
18 MONTHS
MOUSE
IRIS
LIVER
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
INHALATION [UNIT RISK] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
IRIS
1.1E+0
IRIS
IRIS
005134
TRICHLOROANILINE HYDROCHLORIDE. 2.4.6-
ORAL: DIET 18 MONTHS
MOUSE
033663-50-2
VASCULAR SYSTEM TUMORS
2.9E-2
8.2E-7
005142
TRICHLOROANILINE. 2.4.6- 000634-93-5
ORAL: DIET 18 MONTHS
MOUSE VASCULAR SYSTEM
TUMORS
3 4E-2
1E-6
010487
TRICHLOROETHANE. 1.1.2- 000079-00-5
ORAL: GAVAGE 78 WEEKS
MOUSE LIVER
IRIS
CARCINOMA
IRIS
5.7E-2
IRIS
IRIS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II; DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005144
TRICHLOROETHYLENE 000079-01-6

GENERAL COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300.
010483
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-35
-------
HEAST TABLE 3: CARCINOGENICITY
May 19%
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TRICHLOROPHENOL. 2.4.6-
ORAL: DIET 107 WEEKS
MOUSE
TARGET

000088-06-2

BLOOD
CANCER
LEUKEMIA
[SLOPE FACTOR] [UNIT RISK]
[EPA ORAL INHALATION ORAL INHALATION REFERENCE
GROUP] (mg/kg/dayr'dng/kg/day)-1 (ug/L) ' (ug/cu m)-l
IRIS
IRIS
1E-2
IRIS
IRIS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TRICHLOROPROPANE. 1,2.3-
ORAL: GAVAGE
RAT
000096-18-4

MULTIPLE SITES
B2 7E+0
TUMORS.
BENIGN/MALIGNANT.
COMBINED
[EPA GROUP] COMMENT: UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
2E-4
010428
010849
TRIFLURALIN 001582-09-8
IRIS IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010163
TRIMETHYL PHOSPHATE
ORAL: GAVAGE
000512-56-1
103 WEEKS
MOUSE
B2
3.7E-2
UTERUS
TUMORS
1.1E-6
010164
TRINITROTOLUENE. 2.4.6- 000118-96-7
IRIS IRIS
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
010476
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-36
-------
HEAST TABLE 3: CARCINOGEN1CITY May 1995

[SLOPE FACTOR] [UNIT RISK]
EXPERIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES > TARGET CANCER GROUP] (mg/kg/day) '(nig/kg/day)' (ug/L)'1 (ug/cu m)-l

VINYL CHLORIDE 000075-01-4
ORAL: DIET 1001 DAYS A 1.9E+0 5.4E-5 010368
RAT LUNG TUMORS
LIVER TUMORS

ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.

INHALATION: 1 YEAR A 3 OE-1 8.4E-5 010367
INTERMITTENT RAT LIVER TUMORS

INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
INHALATION [UNIT RISK] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE MOST RECENTLY REVIEWED QUANTITATIVE TOXICITY VALUES LISTED HERE APPEAR IN EPA DOCUMENTS PUBLISHED IN 1984 AND 1985. USE OF
THESE VALUES ON AN INTERIM BASIS WAS VALIDATED BY CRAVE (04/05/90) THE AGENCY IS AWARE THAT THESE VALUES DO NOT INCORPORATE CONSIDERABLE
INFORMATION THAT IS NOW AVAILABLE. THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT'S POSITION IS THAT THESE TOXICITY VALUES DO NOT
REFLECT STATE-OF-THE-ART SCIENCE FOR VINYL CHLORIDE. EPA NOW HAS INDIVIDUAL ANIMAL DATA. NOT AVAILABLE WHEN THE ORAL UNIT RISK WAS
CALCULATED. THAT MAY INFLUENCE THIS VALUE. ADDITIONAL INFORMATION THAT MAY BE FACTORED INTO A REVISED QUANTITATIVE TOXICITY VALUE
INCLUDES DATA ON INCREASED SENSITIVITY OBSERVED IN YOUNG ANIMALS AND DATA ON METABOLISM/PHARMACOKINETICS. A UNIT RISK FOR AIR THAT
CONSIDERS INFORMATION ON YOUNG AGE EXPOSURE INCREASES THE RISK (I.E . LOWERS THE RISK SPECIFIC DOSE) BY AT LEAST 3-FOLD. THE
CONSIDERATION OF METABOLISM PHARMACOKINETICS WILL FURTHER INCREASE THE RISK ONE UNPUBLISHED PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL
PREDICTION RESULTS IN A 100-FOLD INCREASED RISK.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254. 3-37
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

ACEPHATE 030560-19-1
010086 CHEVRON CHEMICAL COMPANY. 1982. MRIO NO 00105197. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACEPHATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

ACROLEIN 000107-02-8
005001 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACROLEIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC.

US EPA. 1992. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

ACRYLAHIDE 000079-06-1
010087 JOHNSON K. S GORZINSKI. KM BODNER. ET AL. 1986. CHRONIC TOXICITY AND ONCOGENICITY STUDY ON ACRYLAMIDE INCORPORATED IN THE DRINKING WATER
OF FISCHER 344 RATS. DOW CHEMICAL. USA. MIDLAND. MI.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACRYLAMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-1
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

ACRYLONITRILE 000107-13-1
005004 BIO/DYNAMICS. INC. 1980. A 24-MONTH ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED IN DRINKING WATER TO FISCHER 344
RATS. FINAL REPORT. VOL 1-4. PREPARED BY BIO/DYNAMICS. INC.. DIVISION OF BIOLOGY AND SAFETY EVALUATION EAST MILLSTONE NJ UNDER PROJECT
NO 77-1744 (BDN-77-27) FOR MONSANTO COMPANY. ST LOUIS. MO

BIO/DYNAMICS. INC. 1980. A 24-MONTH ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED TO SPARTAN RATS IN THE DRINKING
WATER. FINAL REPORT. VOL 1 AND 2. PREPARED BY BIO/DYNAMICS. INC.. DIVISION OF BIOLOGY AND SAFETY EVALUATION EAST MILLSTONE NJ UNDER
PROJECT NO 77-1745 FOR MONSANTO COMPANY. ST LOUIS. MO.

QUAST. JF. CE WADE. CG HUMISTON ET AL. 1980. A 2-YEAR TOXICITY AND ONCOGENICITY STUDY WITH ACRYLONITRILE INCORPORATED IN THE DRINKING
WATER OF RATS. PREPARED BY THE TOXICOLOGY RESEARCH LABORATORY. HEALTH AND ENVIRONMENTAL RESEARCH. DOW CHEMICAL USA MIDLAND MI FOR THE
CHEMICAL MANUFACTURERS ASSOCIATION. WASHINGTON. DC.

US EPA. 1983. HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

005003 O'BERG. M. 1980. EPIDEMIOLOGIC STUDY OF WORKERS EXPOSED TO ACRYLONITRILE. J OCCUP MED. 22: 245-252.

US EPA. 1983. HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-2
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY Hay 1995
ALACHLOR 015972-60-8
010180 STOUT. LO. ET AL. 1983. A CHRONIC STUDY OF ALACHLOR ADMINISTERED IN FEED TO LONG-EVANS RATS. EHL #800218. PROJECT NO. ML-80-186. REPORT
MSL-3282/3284. VOL. I AND II. UNPUBLISHED STUDY RECEIVED FEB. 28. 1984 UNDER U.S. EPA REG. NO. 524-316. PREPARED BY MONSANTO
ENVIRONMENTAL HEALTH LABORATORY (EHL). SUBMITTED BY MONSANTO CO.. WASHINGTON. DC. CDL.252496-7.

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALACHLOR. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA 1992 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ALACHLOR PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

ALDRIN 000309-00-2
005006 EPSTEIN. SS. 1975. THE CARCINOGENICITY OF DIELDRIN. PART I. SCI TOTAL ENVIRON. 4: 1-52

NCI (NATIONAL CANCER INSTITUTE). 1977. BIOASSAYS OF ALDRIN AND DIELDRIN FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO
21. NCI-C6-TR-66 DHEW PUBLICATION NO. (NIH) 78-821.

DAVIS. KJ. AND OG FITZHUGH. 1962. TUMORIGENIC POTENTIAL OF ALDRIN AND DIELDRIN FOR MICE. TOXICOL APPL PHARMACOL. 4: 187-189

DAVIS. KJ. 1965. PATHOLOGY REPORT ON MICE FOR ALDRIN. DIELDRIN. HEPTACHLOR. OR HEPTACHLOR EPOXIDE FOR TWO YEARS INT FOOD DRUG ADMIN.

US EPA. 1986. CARCINOGENICITY ASSESSMENT OF ALDRIN AND DIELDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

ALLYL CHLORIDE 000107-05-1
010181 US EPA 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.' OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-3
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REFERENCES FOR HEAST TABLE 3: CARCIMOGEN1CITY Hay 1995

ANILINE 000062-53-3
010088 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1982. 104-WEEK CHRONIC TOXICITY STUDY IN RATS: ANILINE HYDROCHLORIDE. FINAL REPORT.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

ARAMITE 000140-57-8
010206 OSER BL. AND M OSER. 1962. 2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE). II. CARCINOGENICITY. TOXICOL APPL PHARMACOL.
4: 70-88.

POPPER H. SS STEINBERG. BL OSER. AND M OSER. 1960. THE CARCINOGENIC EFFECT OF ARAMITE IN RATS. CANCER. 13(5): 1035-1046.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ARAMITE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-4
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
ARSENIC. INORGANIC 007440-38-2
005007 BROWN. CC AND KC CHU. 1983. APPROACHES TO EPIDEMIOLOGIC ANALYSIS OF PROSPECTIVE AND RETROSPECTIVE STUDIES: EXAMPLE OF LUNG CANCER AND
EXPOSURE TO ARSENIC. IN: RISK ASSESSMENT: PROC SIMS CONFERENCE ON ENVIRONMENTAL EPIDEMIOLOGY. JUNE 28-JULY 2. 1982. ALTA UT. SIAM
PUBLICATION.

BROWN. CC AND KC CHU. 1983. IMPLICATIONS OF THE MULTISTAGE THEORY OF CARCINOGENESIS APPLIED TO OCCUPATIONAL ARSENIC EXPOSURE J NAT
CANCER INST. 70: 455-463.

LEE-FELDSTEIN. A. 1983. ARSENIC AND RESPIRATORY CANCER IN MAN: FOLLOW-UP OF AN OCCUPATIONAL STUDY. IN: ARSENIC: INDUSTRIAL. BIOMEDICAL.
AND ENVIRONMENTAL PERSPECTIVES. W LEDERER AND R FENSTERHEIM. EDS. VAN NOSTRAND REINHOLD. NEW YORK.

BROWN. CC AND KC CHU. 1983. A NEW METHOD FOR THE ANALYSIS OF COHORT STUDIES. IMPLICATIONS OF THE MULTISTAGE THEORY OF CARCINOGENESIS
APPLIED TO OCCUPATIONAL ARSENIC EXPOSURE. ENVIRON HEALTH PERSP. 50: 293-308

HIGGINS. I. 1982. ARSENIC AND RESPIRATORY CANCER AMONG A SAMPLE OF ANACONDA SMELTER WORKERS. REPORT SUBMITTED TO THE OCCUPATIONAL SAFETY
HEALTH ADMINISTRATION IN THE COMMENTS OF THE KENNECOTT MINERALS ON THE INORGANIC ARSENIC RULE MAKING. EXHIBIT 203-5.

ENTERLINE. PE AND GM MARSH. 1982. CANCER AMONG WORKERS EXPOSED TO ARSENIC AND OTHER SUBSTANCES IN A COPPER SMELTER. AM J EPIDEMIOL. 116:
895-911.

US EPA 1984. HEALTH EFFECTS ASSESSMENT FOR ARSENIC. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON DC.

US EPA. 1980. HEALTH ASSESSMENT DOCUMENT FOR INORGANIC ARSENIC. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

010925 TSENG WP. 1977. EFFECTS AND DOSE RESPONSE RELATIONSHIPS OF SKIN CANCER AND BLACKFOOT DISEASE WITH ARSENIC. ENVIRON HEALTH PERSPECT. 19:
108-119.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-5
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY Hay 1995

ASBESTOS 001332-21-4
005010 NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHRYSOTILE ASBESTOS (CAS NO 1200-29-5) IN F344/N RATS
(FEED STUDIES). TECHNICAL REPORT SERIES NO 295.

US EPA. 1988. DRINKING WATER CRITERIA DOCUMENT FOR ASBESTOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON. DC.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

005919 US EPA. 1986. AIRBORNE ASBESTOS HEALTH ASSESSMENT UPDATE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE RESEARCH TRIANGLE
PARK. NC. EPA 600/8-84/003F.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

ATRAZINE 001912-24-9
010380 GIBA-GEIGY. 1986. TWO-YEAR FEEDING STUDY IN THE RAT. CONDUCTED BY AMERICAN BIOGENICS CORP. MRID NO 262714-262727 AVAILABLE FROM EPA
WRITE TO FOI, EPA. WASHINGTON. DC 20460.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ATRAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

AZOBENZENE 000103-33-3
010089 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF AZOBENZENE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECHNICAL REPORT SERIES
NO. 154. US DHEW PUBL NO. (NIH) 79-1710. P 112.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AZOBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-6
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY Hay 1995
BENZENE 000071-43-2
005011 WONG. 0. RW MORGAN AND MO WHORTON. 1983. COMMENTS ON THE NIOSH STUDY OF LEUKEMIA IN BENZENE WORKERS. TECHNICAL REPORT SUBMITTED TO GULF
CANADA. LTD. BY ENVIRONMENTAL HEALTH ASSOCIATES. AUGUST 31. CITED IN US EPA. 1985

OTT. MG. JC TOWNSEND. WA FISHBECK AND RA LANGNER. 1978. MORTALITY AMONG WORKERS OCCUPATIONALLY EXPOSED TO BENZENE. ARCH ENVIRON HEALTH.
33: 3-10.

RINSKY. RA. RJ YOUNG AND AB SMITH. 1981. LEUKEMIA IN BENZENE WORKERS. AM J IND MED 2: 217-245.

US EPA. 1987. MEMORANDUM FROM J. ORME HEB. CSD/ODW TO C. VOGT. JUNE. 1987. CRITERIA AND STANDARDS DIVISION. ODW.

US EPA 1985 INTERIM QUANTITATIVE CANCER UNIT RISK ESTIMATES DUE TO INHALATION OF BENZENE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC. OFFICE OF AIR QUALITY PLANNING AND STANDARDS. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BENZIDINE 000092-87-5
005014 ZAVON. MR. U HOEGG AND E BINGHAM. 1973. BENZIDINE EXPOSURE AS A CAUSE OF BLADDER TUMORS. ARCH ENVIRON HEALTH. 27: 1-73.

US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZIDINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR BENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON. DC.

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR BENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

BENZOTRICHLORIDE 000098-07-7
010092 FUKUDA K. H METSUSHITA AND K TAKEMOTO. 1978. CARCINOGENICITY OF BENZOTRICHLORIDE BY THE ORAL ROUTE OF ADMINISTRATION (J-4774). IN: PROC
52ND ANN MEET JAPANESE INDUSTRIAL HEALTH ASSOC. TSCA 8E SUBMISSION DOCUMENT NO 88-8000360. FICHE #204867. P 516-517.

US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZOTRICHLORIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

BENZO[A]ANTHRACENE 000056-55-3
010182 REFER TO IRIS.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BENZO[A]PYRENE 000050-32-8
010508 NEAL J. RH RIGDON. 1967. GASTRIC TUMORS IN MICE FED BENZO[A]PYRENE. A QUANTITATIVE STUDY TEX REP BIOL MED. 25: 553

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR POLYCYCLIC AROMATIC HYDROCARBONS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. FOR THE OFFICE OF WATER. WASHINGTON. DC.

BENZO[B]FLUORANTHENE 000205-99-2
010183 REFER TO IRIS.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

BENZO[K]FLUORANTHENE 000207-08-9
010090 REFER TO IRIS.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BENZYL CHLORIDE 000100-44-7
010093 LIJINSKI W. 1986. CHRONIC BIOASSAY OF BENZYL CHLORIDE IN F344 RATS AND (C57BL/6J X BALB/OF1 MICE. J NATL CANCER INST. 76. 1231-1236.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-8
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY Hay 1995
BERYLLIUM 007440-41-7
005018 SCHROEDER. HA AND M MITCHNER. 1975. LIFE-TIME STUDIES IN RATS: EFFECTS OF ALUMINUM. BARIUM. BERYLLIUM AND TUNGSTEN. J NUTR. 105: 421-427

US EPA. 1991. DRINKING MATER CRITERIA DOCUMENT FOR BERYLLIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

005017 WAGONER. JK. PF INFANTE AND DL BAYLISS. 1980. BERYLLIUM: AN ETIOLOGIC AGENT IN THE INDUCTION OF LUNG CANCER. NONNEOPLASTIC RESPIRATORY
DISEASE. AND HEART DISEASE AMONG INDUSTRIALLY EXPOSED WORKERS. ENVIRON RES 21: 15-34.

US EPA. 1987. HEALTH ASSESSMENT DOCUMENT FOR BERYLLIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

BIS(2-CHLOROETHYL) ETHER 000111-44-4
005076 INNES. JRM. BM ULLAND. MG VALERIO ET AL. 1969. BIOASSAY OF PESTICIDES AND INDUSTRIAL CHEMICALS FOR TUMORIGENICITY IN MICE: A PRELIMINARY
NOTE. J NATL CANCER INST. 42: 1101-1114.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR BIS(2-CHLOROETHYL)ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLOROALKYL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

BIS(2-CHLORO-1-METHYLETHYL) ETHER 000108-06-1
005079 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENIC BIOASSAY OF BIS(2-CHLORO-1-METHYLETHYL) ETHER (70*) CONTAINING
2-CHLORO-l-METHYLETHYL(2-CHLOROPROPYL) ETHER (30X) IN B6C3F1 MICE (GAVAGE STUDY). NCI CARCINOGEN TECH REP SER NO 239 105 P. ALSO PUBL AS
DHHS (NIH) 83-1795

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HALOETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
R3-9
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

BIS(2-ETHYLHEXYL) PHTHALATE / (DEHP) 000117-81-7
005120 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF DK2-ETHYLHEXYL) PHTHALATE (CAS NO 117-81-7) IN F344 RATS AND B6C3F1
MICE (FEED STUDY). NTP TECH REPORT SER NO 217. NIH/PUB-82-1773. NTP-80-37. NTIS PB82-184011.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACID ALKYL. ARYL AND ALKYL/ARYL ESTERS. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

BIS(CHLOROMETHYL) ETHER 000542-88-1
005077 KUSCHNER. M. S LASKIN. RT DREW. ET AL. 1975. INHALATION CARCINOGENICITY OF ALPHA HALO ETHERS: III LIFETIME AND LIMITED PERIOD INHALATION
STUDIES WITH BIS(CHLOROMETHYL) ETHER AT 0.1 PPM. ARCH ENVIRON HEALTH 30(2). 73-77

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BROMODICHLOROMETHANE • 000075-27-4
005148 NTP (NATIONAL TOXICOLOGY PROGRAM). 1987. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMODICHLOROMETHANE (CAS
NO 75-27-4) IN F344 RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP. RESEARCH TRIANGLE PARK. NC NTP TR 321. US DEPT OF HEALTH AND HUMAN
SERVICES. PUBLIC HEALTH SERVICE. NATIONAL INSTITUTE OF HEALTH.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE WASHINGTON DC
ECAO-CIN-H083.

US EPA 1992. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

BROMOETHENE / (VINYL BROMIDE) 000593-60-2
010094 BENYA TJ. WM BASEY. MA DORATO AND PE BERTEAU 1982 INHALATION CARCINOGENICITY BIOASSAY OF VINYL BROMIDE IN RATS TOXICOL APPL PHARMACOL
64: 367-379.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOETHENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
R3-10
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
BROMOFORM 000075-25-2
005150 NTP (NATIONAL TOXICOLOGY PROGRAM). 1988. TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIHALOMETHANE (BROMOFORM) (CAS
NO 75-25-2) IN F344 RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP-TR 350

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BUTADIENE. 1.3- 000106-99-0
010477 NTP (NATIONAL TOXICOLOGY PROGRAM). 1984. TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.3-BUTADIENE (CAS 106-99-0) IN B6C3F1 MICE (INHALATION
STUDIES).

US EPA. 1985. MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF 1.3-BUTADIENE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. WASHINGTON.
DC. EPA 600/8-85-004F. NTIS-PB86-12507.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3-BUTADIENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BUTYL BENZYL PHTHALATE. N- 000085-68-7
005122 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF BUTYLBENZYL PHTHALATE (CAS. NO 85-68-7) IN F344 RATS AND B6C3F1 MICE
(FEED STUDY). NTP TECH REP. NTIS PB83-118398. RESEARCH TRIANGLE PARK. NC

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS (PAE)S PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-11
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

CADMIUM 007440-43-9
005019 THUN. MJ. TM SCHNORR. AB SMITH AND WE HALPERIN. 1985. MORTALITY AMONG A COHORT OF US CADMIUM PRODUCTION WORKERS' AN UPDATE. J NATL CANCER
INST. 74(2): 325-333.

US EPA. 1985. UPDATED MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF CADMIUM. ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR CADMIUM.
(MAY 1981. EPA 600/8-81-023) EPA 600/8-83-025F.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

CAPTAFOL 002425-06-1
010095 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAFOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CAPTAN 000133-06-2
010184 NCI (NATIONAL CANCER INSTITUTE). 1977. BIOASSAY OF CAPTAN FOR POSSIBLE CARCfNOGENICITY CAS NO. 133-06-2. NTIS PB-273475

CHEVRON. 1982. UNPUBLISHED STUDY.

BIODYNAMICS. 1983. SUBMITTED CHEVRON CHEMICAL CORPORATION. UNPUBLISHED STUDY

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CARBAZOLE 000086-74-8
010096 TSUDA H. A HAZIWARA. M SHIBATA. M OHSIMA AND N ITO. 1982. CARCINOGENIC EFFECT OF CARBAZOLE IN THE LIVER OF (C57BL/6N X C3G/HEN)F1 MICE J
NATL CANCER INST. 69: 1383-1389.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBAZOLE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
R3-12
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

CARBON TETRACHLORIDE 000056-23-5
005022 DELIA PORTA. GB. B TERRACINI AND KP SHUBIK. 1961. INDUCTION WITH CARBON TETRACHLORIDE OF LIVER CELL CARCINOMAS IN HAMSTERS. J NATL CANCER
INST. 26: 855-863.

EDWARDS. J. WE HESTON AND HA DALTON. 1942. INDUCTION OF THE CARBON TETRACHLORIDE HEPATOMA IN STRAIN L MICE. J NATL CANCER INST. 3:
297-301.

NCI (NATIONAL CANCER INSTITUTE). 1976. REPORT ON CARCINOGENESIS BIOASSAY OF CHLOROFORM. NTIS PB264-018. NCI-CG-TR-3.

US EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR CARBON TETRACHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR CARBON TETRACHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

CHLORANIL 000118-75-2
010097 BRL (BIONETICS RESEARCH LABS. INC.). 1968. EVALUATION OF CARCINOGENIC. TERATOGENIC AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES AND
INDUSTRIAL CHEMICALS. VOLUME I: CARCINOGENIC STUDY. NTIS PB 223159.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORANIL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHLORDANE 000057-74-9
005024 VELSICOL. 1973. EIGHTEEN MONTH ORAL CARCINOGENIC STUDY IN MICE. DECEMBER 14, 1973 MRID NO 00067568. AVAILABLE FROM EPA WRITE TO FOI
EPA. WASHINGTON. DC 20460.

NCI (NATIONAL CANCER INSTITUTE). 1977. BIOASSAY OF CHLORDANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 8 ALSO
PUBL AS DHEW PUBL NO (NIH) 77-808.

US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLORDANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

US EPA. 1986. CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-13
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

CHLORO-2-METHYLANILINE HYDROCHLORIDE. 4- 003165-93-3
010419 WEISBURGER EK. AB RUSSFIELD. F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-CHLORO-2-METHYLANILINE AND 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE. PREPARED
BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF
SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHLORO-2-METHYLANILINE. 4- 000095-69-2
010098 WEISBURGER EK. AB RUSSFIELD. F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

CHLOROBENZILATE 000510-15-6
010848 BRL (BIONETICS RESEARCH LABORATORIES). 1968. EVALUATION OF CARCINOGENIC. TERATOGENIC AND MUTAGENIC ACTIVITIES OF SELECTED AND INDUSTRIAL
CHEMICALS. I. CARCINOGENIC STUDY. PREPARED FOR NATIONAL CANCER INSTITUTE. REPORT NO NCI DCCP-C6 1973-1-1. NTIS PB-223-157 P 17 27-31
35. 39. 56-57. 68.

US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROBENZILATE. PREPARED BY THE OFFICE OF HEATH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.
R3-14
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

CHLOROFORM 000067-66-3
005036 JORGENSON. TA. EF MEIERHENRY. CJ RUSHBROOK ET AL. 1985. CARCINOGEN1CITY OF CHLOROFORM IN DRINKING WATER TO MALE OSBORNE-MENDEL RATS AND
FEMALE B6C3F1 MICE. FUND APPL TOXICOL(USA). 5(4): 760-769.

US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

005035 NCI (NATIONAL CANCER INSTITUTE). 1976. REPORT ON CARCINOGENESIS BIOASSAY OF CHLOROFORM. NTIS PB264-018.

US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR CHLOROFORM. PREPARED BY THE OFFICE OF HEALTH AND BENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

CHLOROMETHANE 000074-87-3
005038 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1981. FINAL REPORT ON 24-MONTH INHALATION STUDY ON METHYL CHLORIDE PREPARED BY
BATTELLE-COLUMBUS LABORATORIES. COLUMBUS. OH DECEMBER 31.

NIOSH (NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH). 1984. CARCINOGENIC RISK ASSESSMENT FOR OCCUPATIONAL EXPOSURE TO
MONOHALOMETHANES. NTIS PB85-111623.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL CHLORIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR CHLOROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

CHLOROMETHYL METHYL ETHER 000107-30-2
005081 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HALOETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-15
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
CHLORONITROBENZENE. 0- 000088-73-3
010099 WEISBURGER EK. AB RUSSFIELD. F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

CHLORONITROBENZENE. P- 000100-00-5
010100 WEISBURGER EK. AB RUSSFIELD. F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

CHLOROTHALONIL 001897-45-6
010384 IRDC. 1985. TUMORIGENICITY STUDY IN RATS. CHLOROTHALONIL. 099-5TX-80-234-008.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROTHALONIL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHROMIUM(VI) 018540-29-9
005091 MANCUSO. TF. 1975. INTERNATIONAL CONFERENCE ON HEAVY METALS IN THE ENVIRONMENT. TORONTO. CANADA. OCT 27-31. CITED IN US EPA. 1984.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXAVALENT CHROMIUM. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE
OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA 1984. HEALTH ASSESSMENT DOCUMENT FOR CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE US ENVIRONMENTAL PROTECTION AGENCY. RESEARCH TRIANGLE PARK. NC

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CHRYSENE 000218-01-9
010185 REFER TO IRIS.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-16
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

COKE OVEN EMISSIONS 008007-45-2
005039 MAZUMOAR S. C REDMOND. W SOLLECITO AND N SUSSMAN 1975. AN EPIDEMIOLOG1CAL STUDY OF EXPOSURE TO COAL-TAR-PITCH VOLATILES AMONG COKE OVEN
WORKERS. APCAJ. 25(4): 382-389.

LAND. CE. 1976. PRESENTATION AT OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION HEARINGS ON COKE OVEN STANDARDS.

US EPA. 1984. CARCINOGEN ASSESSMENT OF COKE OVEN EMISSIONS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CARCINOGEN
ASSESSMENT GROUP. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CREOSOTE. COAL TAR 008001-58-9
005042 REFER TO IRIS.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

CRESOL, M- / (3-METHYLPHENOL) 000108-39-4
010187 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CRESOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

CRESOL. 0- / (2-METHYLPHENOL) 000095-48-7
010186 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CRESOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CRESOL. P- / (4-METHYLPHENOL) 000106-44-5
010188 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CRESOLS. PREPARED BY THE OFFICE OF HEALTH "AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)1WORK GROUP.
R3-17
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

CROTONALDEHYDE 000123-73-9
010190 CHUNG. FL. T TAMAKA. SS HECHT. 1986. INDUCTION OF LIVER TUMORS IN F344 RATS BY CROTONALDEHYOE CANCER RES. 46: 1285-1289.

US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CROTONALDEHYDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA 1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CYANAZINE 021725-46-2
010944 BOGDANFFY MS. 1990. COMBINED CHRONIC TOXICITY/ONCOGENICITY STUDY WITH CYANAZINE (INR-1957) 2-YEAR FEEDING STUDY IN RATS PREPARED BY E.I.
DU PONT DE NEMOURS AND CO.

US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

ODD 000072-54-8
010291 TOMATIS. L. V TURUSOV. RT CHARLES AND M BOICCHI. 1974. EFFECT OF LONG-TERM EXPOSURE TO l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHYLENE. TO
l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHANE. AND TO THE TWO CHEMICALS COMBINED ON CF-1 MICE. J NATL CANCER INST. 52(3)- 883-891

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DOE 000072-55-9
010292 TOMATIS L V TURUSOV. RT CHARLES AND M BOICCHI. 1974. EFFECT OF LONG-TERM EXPOSURE TO l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHYLENE. TO
l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHANE. AND TO THE TWO CHEMICALS COMBINED ON CF-1 MICE. J NATL CANCER INST. 52(3): 883-891

NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF DDT. TOE AND P.P'-DDE FOR POSSIBLE CARCINOGENICITY. NCI REPORT NO 131. DHEW PUBL NO
(NIH) 78-1386

ROSSI L. 0 BARBIERI. M SANGUINETI. JRP CABRAL. P BRUZZI AND L SANTI. 1983 CARCINOGENICITY STUDY WITH TECHNICAL-GRADE DDT AND DDE IN
HAMSTERS. CANCER RES. 43: 776-781.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-18
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN 1C ITY May 1995

DDT 000050-29-3
005044 US EPA. 1986. THE CARCINOGEN ASSESSMENT GROUP'S EVALUATION OF THE CARCINOGEN 1C ITY OF DICOFOL (KELTHANE) DDT DDE AND ODD (TDE)
PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC FOR THE HAZARD EVALUATION
DIVISION. OFFICE OF PESTICIDE PROGRAMS. OFFICE OF PESTICIDES AND TOXIC SUBSTANCES. WASHINGTON. DC

US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR DDT. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC. EPA 540/1-86-026.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

DECABROMODIPHENYL ETHER 001163-19-5
010102 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DECABROMODIPHENYL OXIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

DIALLATE 002303-16-4
010103 BRL (BIONETICS RESEARCH LABS. INC.). 1968. EVALUATION OF CARCINOGENIC. TERATOGENIC. AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES AND
INDUSTRIAL CHEMICALS. VOL 1. CARCINOGENIC STUDY. PREPARED FOR NATIONAL CANCER INSTITUTE. US DEPARTMENT OF COMMERCE. WASHINGTON. DC. NTIS
r D- ttviiby .
INNES. JRM. BM ULLAND, MG VALERIO. ET AL. 1969. BIOASSAY OF PESTICIDES AND INDUSTRIAL CHEMICALS FOR TUMORIGENICITY IN MICE A PRELIMINARY
NOTE. J NATL CANCER INST. 42: 1101-1114.

US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIALLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

DIBENZO[A.H]ANTHRACENE 000053-70-3
010191 REFER TO IRIS.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-19
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995
DIBROMO-3-CHLOROPROPANE. 1.2 000096-12-8
010519 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF 1.2-DIBROMO-3-CHLOROPROPANE (CAS NO 96-12-8) IN F344 RATS AND B6C3F1
MICE (INHALATION STUDY). NTP-TR-NO 81-21.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

010484 HAZELTON LABORATORIES. INC. 1977. 104 WEEK DIETARY STUDY IN RATS. 1.2-DIBROMO-3-CHLOROPROPANE (DBCP). FINAL REPORT. UNPUBLISHED REPORT
SUBMITTED TO DOW CHEMICAL CO.. MIDLAND. MI. OCTOBER 29. 1977.

US EPA. 1988. DRINKING WATER CRITERIA DOCUMENT FOR DIBROMOCHLOROPROPANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON DC. ECAO-CIN-410.

US EPA. 1988. ASSESSMENT OF THE CARCINOGENIC POTENTIAL OF 1.2-DIBROMO-3-CHLOROPROPANE (DBCP). PREPARED BY THE CARCINOGEN ASSESSMENT
GROUP. AVAILABLE THROUGH RCRA/SUPERFUND DOCKET

DIBROMOCHLOROMETHANE 000124-48-1
010891 NTP (NATIONAL TOXICOLOGY PROGRAM). 1985 TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORODIBROMOMETHANE (CAS NO 124-48-1) IN F/344/N RATS
AND B6C3F1 MICE. NTP TECH REP SER NO 282. DHHS NO NIH 85-2538.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

DIBROMOETHANE. 1.2- 000106-93-4
005071 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF 1.2-DIBROMOETHANE (ETHYLENE DIBROMIDE) (CAS NO 106-93-4) IN F344 RATS
AND B6C3F1 MICE (INHALATION STUDY). NTP TECH REP SER NO 210. NIH PUBL NO 82-1766

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

005818 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1.2-DIBROMOETHANE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS REPORT SERIES NO
86. PB-288-428.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE DIBROMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2-DIBROMOETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

R3-20
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY Nay 1995

DICHLORO-2-BUTENE. 1.4- 000764-41-0
005053 El DUPONT DE NEMOURS AND CO. 1986. LONG-TERM INHALATION STUDY WITH 1.4-DICHLOROBUTENE-2 (DCB) IN RATS FINAL REPORT OTS 8(E) FICHE
0509754.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DICHLOROBUTENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON, DC.

DICHLOROBENZENE. 1.4- 000106-46-7
005050 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.4-DICHLOROBENZENE IN F344/N RATS AND B6C3F1 MICE --
GALLEY DRAFT. US DHHS. PHS. NIH TECH REP SER NO 319.

CONTAMINANTS. 1987. FR (JULY 8). 52: 25690-25717.

DICHLOROBENZIDINE. 3.31- 000091-94-1
005815 STULA. EF. H SHERMAN. JA ZAPP. ET AL. 1975. EXPERIMENTAL NEOPLASIA IN RATS FROM ORAL ADMINISTRATION OF 3 3'-DICHLOROBENZIDINE
4.4'-METHYLENE-BIS(2-CHLOROANILINE) AND 4.4'-METHYLENE-BIS (2-METHYLANILINE) TOXICOL APPL PHARMACOL. 31: 159-175.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

DICHLOROETHANE. 1.1- 000075-34-3
005055 US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DICHLOROETHANE. 1.2- 000107-06-2
005058 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1.2-DICHLOROETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO
55. DHEW PUBL NO (NIH) 78-1361.

US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR 1.2-DICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
WASHINGTON. DC. EPA 600/8-84-006F.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-21
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

ntrm OROFTHYI FNF 1 1- 000075-35-4
005060 NTP' (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF VINYLIDENE CHLORIDE (CAS NO 75-35-4) IN F344 RATS AND B6C3F1 MICE
(GAVAGE STUDY). NTP TECH REP SER NO 228. DHHS NO NIH 82-1784.

US EPA 1985 HEALTH ASSESSMENT DOCUMENT FOR VINYLIDENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC

US EPA 1988 UPDATED HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHYLENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

005059 MALTONI C G LEFEMINE P CHIECO ET AL. 1985. EXPERIMENTAL RESEARCH ON VINYLIDENE CHLORIDE CARCINOGENESIS. IN: ARCHIVES OF RESEARCH ON
INDUSTRIAL'CARCINOGENESIS. VOL 3. c. MALTONI AND M MEHLMAN. ED. PRINCETON SCIENTIFIC PUBLISHERS. PRINCETON. NJ.

US EPA 1985 HEALTH ASSESSMENT DOCUMENT FOR VINYLIDENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

nrrm OROPRDPANF 1 2- 000078-87-5
005062 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. NTP TECHNICAL REPORT ON THE CARCINOGENESIS STUDIES OF l^^ICHLOROPROPANE WOPYLENE
DICHLORIDE). (CAS NO. 78-87-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP-82-092. NIH PUBL NO 84-2519. NTP TR 263 US DHHS.
PHS. NIH. AUGUST. 1986 DRAFT.

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR 1.2-DICHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
R3-22
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY Hay 1995

DICHLOROPROPENE. 1.3- / (TELONE II) 000542-75-6
010946 NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF TELONE II IN F344/N RATS AND B6C3F1 MICE US DEPT
HEALTH AND HUMAN SERVICES. TECH REPORT SER NO 269.

US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR 1.3-DICHLOROPROPENE PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI OH FOR THE OFFICE OF WATER WASHINGTON
DC.

010104 LOMAX LG. WT STOTT. KA JOHNSON. LL CALHOUN. BL YANO AND JF QUAST 1989 THE CHRONIC TOXICITY AND ONCOGENICITY OF INHALED TECHNICAL GRADE
1.3-DICHLOROPROPENE IN RATS AND MICE FUND APPL TOXICOL. 12: 418-431

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-23
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY Hay 1995

nmnoTM 000060-57-1
005816 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAYS OF ALDRIN AND DIELDRIN FOR POSSIBLE CARCINOGENICITY. NATIONAL CANCER INSTITUTE
CARCINOGEN TECH REP SER NO 22 NCI-CG-TR-22. ALSO PUBL AS DHEW PUBL NO (NIH) 78-882.

WALKER. AIT. E THORPE AND DE STEVENSON. 1972. THE TOXICOLOGY OF DIELDRIN (HEOD): I LONG-TERM ORAL TOXICITY STUDIES IN MICE FOOD COSMET
TOXICOL. 11: 415-432.

MEIERHENREY. EF. BH REUBER. ME GERSHWIN ET AL. 1983. DIELDRIN INDUCED MALLORY BODIES IN HEPATIC TUMORS OF MICE OF DIFFERENT STRAINS.
HEPATOLOGY. 3: 90-95.

TENNEKES, HA. AS WRIGHT. KM DIX AND JH KOEMAN. 1981. EFFECTS OF DIELDRIN. DIET AND BEDDING ON ENZYME FUNCTION AND TUMOR INCIDENCE IN
LIVERS OF MALE CF-1 MICE. CANCER RES. 41: 3615-3620

THORPE E AND AIT WALKER. 1973. THE TOXICOLOGY OF DIELDRIN (HEOD). II. COMPARATIVE LONG-TERM ORAL TOXICITY STUDIES IN MICE WITH DIELDRIN.
DDT. PHENOBARBITONE. BETA-BHC AND GAMMA-BHC FOOD COSMET TOXICOL. 11' 433-442

DAVIS. KJ. 1965. PATHOLOGY REPORT ON MICE FED ALDRIN. DIELDRIN. HEPTACHLOR OR HEPATOCHLOR EPOXIDE FOR TWO YEARS. INTERNAL FDA MEMORANDUM
TO OR! AJ LEHMAN. JULY 19.

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR DIELDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND 'ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DTETHYLSTILBESTROL 000056-53-1
010485 GASS. ET AL. 1964. CARCINOGENIC DOSE-RESPONSE CURVE TO ORAL DIETHYLSTILBESTEROL J NATL CANCER INST. 33: 971-977.

FPA 1988 EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIETHYLSTILBESTEROL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
^mim^oS^s^m OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.
niMFTHnXYRFN7TniNE 33'- 000119-90-4
010106 SELLAK'UMAR AR. R MONTESANO AND A SAFFIOTI. 1969. AROMATIC AMINES CARCINOGENICITY IN HAMSTERS. PROC AM ASSOC CANCER RES. 10: 78.
*
OSHA/NIOSH (OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION/NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH). 1980. HEALTH HAZARD.
ALERT BENZIDINE. 0-TOLIDINE AND 0-DIANISIDINE BASED DYES. DHHS (NIOSH) PUBL NO. 81-106

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 3.3'-DIMETHOXYBENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.

WASHINGTON. DC.

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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

DIHETHYLANILINE HYDROCHLORIDE. 2.4- 021436-96-4
010108 WEISBURGER EK. AB RUSSFIELD. F HOM8URGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-DIMETHYLANILINE AND 2.4-DIMETHYLANILINE HYDROCHLORIDE. PREPARED BY THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE. WASHINGTON. DC.

DIMETHYLANILINE. 2.4- 000095-68-1
010107 WEISBURGER EK. AB RUSSFIELD. F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

DIMETHYLBENZIDINE. 3.3'- 000119-93-7
010109 GRISWOLD DP JR. AE CASEY. EK WEISBURGER AND JH WEISBURGER. 1968. THE CARCINOGENICITY OF MULTIPLE INTRA-GASTRIC DOSES OF AROMATIC AND
HETEROCYCLIC NITRO OR AMINO DERIVATIVES IN YOUNG FEMALE SPRAGUE-DAWLEY RATS CANCER RES. 28(5): 924-933.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 3.3'-DIMETHYLBENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

DIMETHYLBENZ[A]ANTHRACENE. 7.12- 000057-97-6
010297 FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC ASSESSMENT OF THIS COMPOUND.

DIMETHYLHYDRAZINE. 1.2- 000540-73-8
010962 TOTH B AND K PATEL. 1982. CARCINOGENICITY DOSE RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF 1.2-DIMETHYL HYDRAZINE DIHYDROCHLORIDE IN
MICE. I. LIGHT AND TRANSMISSION ELECTRON MICROSCOPE STUDY OF COLONIC NEOPLASMS AM J PATH 84: 69-86

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2-DIMETHYLHYDRAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1989. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1.2-DIMETHYLHYDRAZINE PREPARED BY THE CARCINOGEN ASSESSMENT GROUP. OFFICE
OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND
REMEDIAL RESPONSE AND OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY Hay 1995
DIMETHYLSULFATE 000077-78-1
010112 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYL SULFATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DINITROTOLUENE. 2.4- 000121-14-2
005066 ELLIS. HV. SH HAGEUSEN. JR JODGSON ET AL. 1979. MAMMALIAN TOXICITY OF MUNITIONS COMPOUNDS. PHASE III EFFECTS OF LIFETIME EXPOSURE. PART
I. 2.4-DINITROTOLUENE. NTIS AD-A077692. 281 P.

US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR 2.4- AND 2.6-DINITROTOLUENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DINITROTOLUENE, 2.6- 000606-20-2
005068 ELLIS HV. SH HAGUESEN. JR JODGSON. ET AL. 1979. MAMMALIAN TOXICITY OF MUNITION COMPOUNDS. PHASE III. EFFECTS OF LIFETIME EXPOSURE. PART
I. 2.4-DiNITROTOLUENE. NTIS AD-A077692. 281 P.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DIOXANE. 1.4- 000123-91-1
010298 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1.4-DIOXANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 80. DHEW
PUBLICATION NO (NIH) PB-285-711.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-26
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

DIPHENYLHYDRAZINE. 1.2- 000122-66-7
005070 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF HYDRAZOBENZENE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO 92
DHEW PUBL NO (NIH) 78-1342.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 1.2-DIPHENYLHYDRAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.2-DIPHENYLHYDRAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR 1.2-DIPHENYLHYDRAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS WASHINGTON
DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DIRECT BLACK 38 001937-37-7
010113 NCI (NATIONAL CANCER INSTITUTE). 1978 13-WEEK SUBCHRONIC TOXICITY STUDIES ON DIRECT BLUE 6. DIRECT BLACK 38 AND DIRECT BROWN 95 DYES
NCI CARCINOGENESIS TECH REP SER NO. 108. P 127.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT BLACK 38 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

DIRECT BLUE 6 002602-46-2
010114 NCI (NATIONAL CANCER INSTITUTE). 1978. 13-WEEK SUBCHRONIC TOXICITY STUDIES OF DIRECT BLUE 6. DIRECT BLACK 38 AND DIRECT BROWN 95 DYES
NCI CARCINOGENESIS. TECH REP SER NO. 108. P 127.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT BLUE 6 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DIRECT BROWN 95 016071-86-6
010115 NCI (NATIONAL CANCER INSTITUTE). 1978. 13-WEEK SUBCHRONIC TOXICITY STUDIES OF DIRECT BLUE 6. DIRECT BLACK 38 AND DIRECT BROWN 95 DYES
NCI CARCINOGENESIS. TECH REP SER NO. 108. P 127 '

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT BROWN 95 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
DIRECT SKY BLUE 6B 002610-05-1
010116 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT SKY BLUE 6B. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

EPICHLOROHYDRIN 000106-89-8
010117 LASKIN S. AR SELLAKUMAR. M KUSCHNER. ET AL. 1980. INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN NON-INBRED SPRAGUE-DAWLEY RATS. J NATL
CANCER INST. 65(4): 751-757.

US EPA 1984 HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYORIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC EPA 600/8-83-032F. NTIS PB85-132363.

US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPICHLOROHYDRIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

010198 KONISHI. T. A KAWABATA. A DENDA. ET AL. 1980. FORESTOMACH TUMORS INDUCED BY ORALLY ADMINISTERED EPICHLOROHYDRIN IN MALE WISTAR RATS.
GANN. 71: 922-923.

US EPA 1984 HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC. EPA 600/8-83-032F. NTIS PB85-132363.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

ETHYL ACRYLATE 000140-88-5
010118 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 CARCINOGENESIS STUDIES OF ETHYL ACRYLATE IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES).

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL ACRYLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
R3-28
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

ETHYLENE OXIDE 000075-21-8
010421 DUNKELBERG H. 1982. CARCINOGENICITY OF ETHYLENE OXIDE AND 1.2-PROPYLENE OXIDE UPON INTRA-GASTRIC ADMINISTRATION TO RATS. BR J CANCER. 46:
924-933.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR OXIRANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

010422 SNELLINGS WM. CS WEIL AND RR MORONPOT. 1981. FINAL REPORT. ETHYLENE OXIDE. TWO YEAR INHALATION STUDY. SUBMITTED TO THE US ENVIRONMENTAL
PROTECTION AGENCY BY BUSHEY RUN RESEARCH CENTER. PITTSBURGH PA.

US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR ETHYLENE OXIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC. EPA 600/8-84-009F NTIS PB86-102597.

ETHYLENE THIOUREA 000096-45-7
010947 NTP (NATIONAL TOXICOLOGY PROGRAM). 1992. NTP TECHNICAL REPORT ON THE PERINATAL TOXICOLOGY AND CARCINOGENESIS STUDIES OF ETHYLENE THIOUREA
(CAS NO 96-45-7) IN F344/N RATS AND B6C3F1 MICE. (FEED STUDIES). NTP TR 388 US DEPT OF HEALTH AND HUMAN SERVICES. PUBLIC HEALTH SERVICE.
NATIONAL INSTITUTES OF HEALTH.

US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

FOLPET 000133-07-3
010120 CHEVRON CHEMICAL COMPANY. 1982. CHEVRON STUDY: LIFETIME ONCOGENICITY FEEDING STUDY OF PHOLTON TECHNICAL (SX-946 FOLPET) IN CD-I (ICR
DERIVED) MICE. AUGUST 24. SOCIAL STUDY NO. 1331.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FOLPET. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

FORMALDEHYDE 000050-00-0
010121 KERNS ET AL.. 1983. CARCINOGENICITY OF FORMALDEHYDE IN RATS AND MICE AFTER LONG-TERM INHALATION EXPOSURE. CANCER RES. 43(9): 4382-4392.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FORMALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
R3-29
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

FURAZOLIDONE 000067-45-8
005106 US OHEW. 1976. FUROZOLIOONE (NF-180): NOTICE OF OPPORTUNITY FOR HEARING ON PROPOSAL TO WITHDRAW APPROVAL OF CERTAIN NEW ANIMAL DRUG
APPLICATIONS. FEDERAL REGISTER. 41: 19907-19921.

US DHEW. 1976. FUROZOLIDONE. NIHYDRAZONE. FURALTADONE. NITROFURAZONE. WITHDRAWAL OF PROPOSALS AND NOTICE OF PROPOSED RULE MAKING. FEDERAL
REGISTER. 41: 34884-34921.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITROFURANS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

FURIUM 000531-82-8
005108 COHEN. SM. E ERTURK AND GT BRYAN. 1970. PRODUCTION OF LEUKEMIA AND STOMACH NEOPLASMS IN SWISS. RF. BALB/C AND C3H FEMALE MICE BY FEEDING
N-(4.5-NITRO-2-FURYL-2-THIAZOLYL)ACETAMIDE CANCER RES. 30(9): 2320-2325

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITROFURANS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

GLYCIDALDEHYDE 000765-34-4
010122 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR GLYCIDALDEHYDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-30
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

HEPTACHLOR 000076-44-8
005820 DAVIS K. 1965. PATHOLOGY REPORT ON MICE FED ALDRIN. DIELDRIN, HEPTACHLOR. AND HEPTACHLOR EPOXIDE FOR TWO YEARS. INTERNAL FDA MEMORANDUM
TO DR. AJ LEHMAN. JULY 19.

NCI (NATIONAL CANCER INSTITUTE). 1977. BIOASSAY OF HEPTACHLOR FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 9. DHEW NO
(NIH) 77-809.

EPSTEIN. SS. 1976. CARCINOGENICITY OF HEPTACHLOR AND CHLORDANE. SCI TOTAL ENVIRON 6. 103-154.

REUBER. MD. 1977. HISTOPATHOLOGY OF CARCINOMAS OF THE LIVER IN MICE INGESTING HEPTACHLOR OR HEPTACHLOR EPOXIDE. EXP CELL BIOL. 45:
147-157.

US EPA. 1986. CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR HEPTACHLOR. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

HEPTACHLOR EPOXIDE 001024-57-3
010424 DAVIS KJ. 1965. PATHOLOGY REPORT ON MICE FED ALDRIN. DIELDRIN. HEPTACHLOR AND HEPTACHLOR EPOXIDE FOR TWO YEARS INTERNAL FDA MEMORANDUM
TO DR. A.J. LEHMAN. JULY 19.

VELSICOL CHEMICAL CORPORATION. 1973. MRID NO. 00062678. AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

HEXACHLOROBENZENE 000118-74-1
010365 ERTURK £. RW LAMBRECHT. HA PETERS. DJ CRIPPS £T AL. 1986. ONCOGENICITY OF HEXACHLROBENZENE. IN: HEXACHLROBENZENE: PROC INT SYMP. CR
MORRIS AND JRP CABRAL. ED. IARC SCIENTIFIC PUBL NO. 77. OXFORD UNIVERSITY PRESS. OXFORD P 417-423.

US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER1. WASHINGTON. DC.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

HEXACHLOROBUTADIENE 000087-68-3
005088 KOCIBA. RJ. DG KEYS. GC JERSEY. ET AL. 1977. RESULTS OF A2-YEAR CHRONIC TOXICITY STUDY WITH HEXACHLOROBUTADIENE IN RATS. AM IND HYG ASSOC
J. 38: 589-602.

US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR HEXACHLOROBUTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS WASHINGTON
DC.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROBUTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

HEXACHLOROCYCLOHEXANE. ALPHA- 000319-84-6
010123 ITO N. H NAGASAKI. M ARIA. ET AL. 1973. HISTOLOGICAL AND ULTRASTRUCTURAL STUDIES ON THE HEPATOCARCINOGENICITY OF BENZENE HEXACHLORIDE IN
MICE. J NATL CANCER INST. 51: 817-826.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON, DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

HEXACHLOROCYCLOHEXANE. BETA 000319-85-7
010124 THORPE E AND AIT WALKER. 1973. TOXICOLOGY OF DIELDRIN (HEOD) II. COMPARATIVE LONG-TERM ORAL TOXICITY STUDIES IN MICE WITH DIELDRIN DDT
PHENOBARBITONE. BETA-HCH AND GAMMA-HCH. FOOD COSMET TOXICOL. 11: 433-442

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH'AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-32
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
HEXACHLOROCYCLOHEXANE. DELTA- 000319-86-8
010125 ITO N. H NAGASAKI. H AOE. ET AL. 1975. BRIEF COMMUNICATION: DEVELOPMENT OF HEPATOCELLULAR CARCINOMAS IN RATS TREATED WITH
BENZENEHEXACHLORIDE. J NATL CANCER INST. 54: 801-805.

ITO N. H NAGASAKI. M ARIA. ET AL. 1973. HISTOLOGICAL AND ULTRASTRUCTURAL STUDIES ON THE HEPATOCARCINOGENICITY OF BENZENE HEXACHLORIDE IN
MICE. J NATL CANCER INST. 51: 817-826.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE-OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

HEXACHLOROCYCLOHEXANE. EPSILON- 006108-10-7
010126 GOTO M. M HATTORI. T MIYAGAWA AND M ENOMOTO. 1972. ECOLOGICAL CHEMISTRY II HEPATOHA FORMATION IN MICE AFTER ADMINISTRATION OF HIGH
DOSES OF HEXACHLOROCYCLOHEXANE ISOMERS. CHEMOSPHERE. 1: 279-282.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

HEXACHLOROCYCLOHEXANE. GAMMA- 000058-89-9
005098 THORPE. E AND AIT WALKER. 1973. THE TOXICOLOGY OF DIELDRIN (HEOD). II. COMPARATIVE LONG-TERM ORAL TOXICITY STUDIES IN MICE WITH DIELDRIN.
DDT. PHENOBARBITONE. BETA-BHC AND GAMMA-BHC. FOOD COSMET TOXICOL. 11: 433-442

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.

US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR LINDANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

HEXACHLOROCYCLOHEXANE-TECHNICAL 000608-73-1
010127 MUNIR KM. CS SOMAN AND V SUMATI. 1983. HEXACHLOROCYCLOHEXANE-INDUCED TUMORIGENICITY IN MICE UNDER DIFFERENT EXPERIMENTAL CONDITIONS
TUMORIGENICITY. 69: 383-386.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

HEXACHLOROETHANE 000067-72-1
005090 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF HEXACHLOROETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 68
DHEW NO (NIH) 78-1318.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HEXACHLOROETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED ETHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS WASHINGTON
DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY Hay 1995

HYDRAZINE 000302-01-2
010129 BIANCIFIORI C. 1970. HEPATOMAS IN CBA/CB/SE MICE AND LIVER LESIONS IN GOLDEN HAMSTERS INDUCED BY HYDRAZINE SULFATE J NATL CANCER INST.
44: 943.

US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE AND HYDRAZINE SULFATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

010128 MACEWEN JD. EH VERNOT. CC HAUN. ER KINKEAD AND A HALL. III. 1981. CHRONIC INHALATION TOXICITY OF HYDRAZINE: ONCOGENIC EFFECTS. AIR FORCE
AEROSPACE MEDICAL RESEARCH LABORATORY. WRIGHT-PATTERSON AIR FORCE BASE. OH.

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE AND HYDRAZINE SULFATE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

HYDRAZINE SULFATE 010034-93-2
010131 BIANCIFIORI C. 1970. HEPATOMAS IN CBA/CB/SE MICE AND LIVER LESIONS IN GOLDEN HAMSTERS INDUCED BY HYDRAZINE SULFATE. J NATL CANCER INST.
44: 943.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

010130 MACEWEN JD. EH VERNOT. CC HAUN. ER KINKEAD AND A HALL. III. 1981. CHRONIC INHALATION TOXICITY OF HYDRAZINE: ONCOGENIC EFFECTS AIR FORCE
AEROSPACE MEDICAL RESEARCH LABORATORY. WRIGHT-PATTERSON AIR FORCE BASE. OH

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE AND HYDRAZINE SULFATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY Nay 1995

INDENO[1.2.3-CD]PYRENE 000193-39-5
010192 REFER TO IRIS.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

ISOPHORONE 000078-59-1
005094 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF ISOPHORONE (CAS NO 78-59-1) IN F344/N RATS AND B6C3F1
MICE (GAVAGE STUDIES). NTP TECH REP SER NO 291. DHHS (NIH)86-2547.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOPHORONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ISOPHORONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1992. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

LEAD 007439-92-1
005096 US EPA. 1989. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF LEAD AND LEAD COMPOUNDS. PREPARED BY THE CARCINOGEN ASSESSMENT GROUP OFFICE
OF HEALTH AND ENVIRONMENTAL ASSESSMENT. WASHINGTON DC FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON DC

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR LEAD. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

LINURON 000330-55-2
010383 REFER TO IRIS.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
MERCURIC CHLORIDE 007487-94-7
010971 NTP (NATIONAL TOXICOLOGY PROGRAM). 1993. TOXICOLOGY AND CARCINOGENESIS STUDIES OF MERCURIC CHLORIDE (CAS NO. 7487-94-7) IN F344 RATS
AND B3C3F1 MICE (GAVAGE STUDIES). NTP TECHNICAL REPORT SERIES NO 408. NATIONAL TOXICOLOGY PROGRAM. U.S. DEPARTMENT OF HEALTH AND HUMAN
SERVICES. PUBLIC HEALTH SERVICE. NATIONAL INSTITUTES OF HEALTH. RESEARCH TRIANGLE PARK, NC.

U.S. EPA. 1995. MERCURY STUDY REPORT TO CONGRESS. OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON. DC. EXTERNAL REVIEW DRAFT.
EPA/600/P-94/002Ab.

U.S. EPA. 1994. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

MERCURY. ELEMENTAL 007439-97-6
010973 CRAGLE. D.L.. D.R. HOLLIS. J.R. QUALTERS. W G. TANKERSLEY AND S A. FRY 1984 A MORTALITY STUDY OF MEN EXPOSED TO ELEMENTAL MERCURY.
J. OCCUP. MED. 26(11): 817-821.

U.S. EPA. 1995. MERCURY STUDY REPORT TO CONGRESS. OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON. DC. EXTERNAL REVIEW DRAFT.
EPA/600/P-94/OOAb.

U.S. EPA. 1994. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

METHOXY-5-NITROANILINE. 2- 000099-59-2
010132 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 5-NITRO-O-ANISIDINE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO.
127. 123 P.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXY-5-NITROANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

METHYL-5-NITROANILINE. 2- 000099-55-8
010140 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 5-NITRO-O-TOLUIDINE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGEN TECH REP SER NO. 107.
102 P.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYL-5-NITROANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

METHYLANILINE HYDROCHLORIDE. 2- 000636-21-5
010134 HECHT SS. A El-BOYOUMY. A RIVENSON AND E FIALA. 1982. COMPARATIVE CARCINOGENICITY OF 0-TOLUIDINE HYDROCHLORIDE AND 0-NITROSOTOLUENE IN
F-344 RATS. CANCER LETT. 16(1): 103-108.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYLANILINE AND 2-METHYLANILINE HYDROCHLORIDE PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC.

METHYLANILINE. 2- 000095-53-4
010133 HECHT SS. A EL-BOYOUMY. A RIVENSON AND E FIALA. 1982. COMPARATIVE CARCINOGENICITY OF 0-TOLUIDINE HYDROCHLORIDE AND 0-NITROTOLUENE IN
F-344 RATS. CANCER LETT. 16(1): 103-108.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIDINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

METHYLCHOLANTHRACENE. 3- 000056-49-5
010299 FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC ASSESSMENT OF THIS COMPOUND
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995
METHYLENE CHLORIDE / (DICHLOROMETHANE) 000075-09-2
005100 NCA (NATIONAL COFFEE ASSOCIATION). 1983. TWENTY-FOUR MONTH ONCOGENICITY STUDY OF METHYLENE CHLORIDE IN MICE. PREPARED BY HAZELTON
LABORATORIES. AMERICA INC. VIENNA. VA.

NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF DICHLOROMETHANE (METHYLENE CHLORIDE) (CAS NO 75-09-2)
IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES). NTP TECH REP SER NO 306. DHHS (NIH) 86-2562.

US EPA 1985 ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR DICHLOROMETHANE (METHYLENE CHLORIDE). UPDATED CARCINOGENICITY ASSESSMENT OF
DICHLOROMETHANE (METHYLENE CHLORIDE). OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

005904 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF DICHLOROMETHANE (METHYLENE CHLORIDE) (CAS NO 75-09-2)
IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES). NTP TECH REP SER NO 306. OHHS (NIH) 86-2562.

US EPA 1989 UPDATED HEALTH EFFECTS ASSESSMENT FOR METHYLENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

METHYLENE-BIS(2-CHLOROANILINE). 4.4'- 000101-14-4
010425 KOMMINENI C. DH GROTH. IJ FROCKT. RW VOELKER AND RP STANOVICK. 1979. DETERMINATION OF THE TUMORIGENIC POTENTIAL OF
METHYLENE-BIS-ORTHO-CHLOROANILINE. J ENVIRON PATH TOXICOL. 2(5): 149-171.

STULA EF H SHERMAN JP ZAPP JR AND JW CLAYTON. 1975. EXPERIMENTAL NEOPLASIA IN RAT FROM ORAL ADMINISTRATION OF 3.3-DICHLOROBENZIDINE.
4.4-METHYLENE-BIS(2-CHLOROANiLINE) AND 4.4-METHYLENE-BIS(2-METHYLANILINE) TOXICOL APPL PHARMACOL 31(1). 159-176.

US EPA 1990 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4.4-METHYLENE-BIS(2-CHLOROANILINE). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

METHYLENE-BIS(N.N'-DIMETHYL)ANILINE. 4.41- 000101-61-1
010137 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF 4.41-METHYLENE-BIS(N.N'-DIMETHYL)BENZENAMINE FOR POSSIBLE CARCINOGENICITY. NCI
CARCINOGEN. TECH REP SER NO. 186. CAS 101-61-1.

US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4.4'-METHYLENE-BIS(N.N1-DIMETHYDANILINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

R3-39
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

METHYLMERCURY 022%7-92-6
010972 TAMASHIRO. H.. M. ARAKAKI. H. AKAGI. M. FUTATSUKA AND L.H. ROHT. 1984. CAUSES OF DEATH IN MINAMATA DISEASE- ANALYSIS OF DEATH
CERTIFICATES.. INT. ARCH. OCCUP. ENVIRON. HEALTH. 54: 135-146.

U.S. EPA. 1995. MERCURY STUDY REPORT TO CONGRESS. OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON DC EXTERNAL REVIEW DRAFT
EPA/600/P-94/002Ab.

U.S. EPA. 1994 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

METOLACHLOR 051218-45-2
010951 US EPA. 1993. REVISED AND UPDATED DRINKING MATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METOLACHLOR PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

HIREX 002385-85-5
010952 NTP (NATIONAL TOXICOLOGY PROGRAM). 1990. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF MIREX (CAS NO 2385-85-5) IN
F344/N RATS. (FEED STUDIES). NTP TR 313. US DEPT OF HEALTH AND HUMAN SERVICES. PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH.

US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

NIAGARA BLUE 46 002429-74-5
010141 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NIAGARA BLUE 4B PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
R3-40
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
NICKEL REFINERY DUST
005103 CHOVIL. A. RB SUTHERLAND AND M HALLIDAY. 1981. RESPIRATORY CANCER IN A COHORT OF NICKEL SINTER PLANT WORKERS. BR J IND MED. 38. 327-333.

PETO. J. H CUCKLE. R DOOL. ET AL. 1984. RESPIRATORY CANCER MORTALITY OF WELSH NICKEL REFINERY WORKERS. IN: NICKEL IN THE HUMAN
ENVIRONMENT: PROCEEDINGS OF A JOINT SYMPOSIUM. MARCH. 1983. IARC SCIENTIFIC PUBL NO 53. IARC. LYON. FRANCE. P. 36-46.

ENTERLINE. PE AND GM MARSH. 1982. MORTALITY AMONG WORKERS IN A NICKEL REFINERY AND ALLOY MANUFACTURING PLANT IN WEST VIRGINIA J NAT
CANCER INST. 68: 925-933.

MAGNUS. K. A ANDERSEN AND A HOGETVEIT. 1982. CANCER OF RESPIRATORY ORGANS AMONG WORKERS AT A NICKEL REFINERY IN NORWAY INT J CANCER. 30:
681-685.

US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR NICKEL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NICKEL SUBSULFIDE 012035-72-2
005768 CHOVIL. A. RB SUTHERLAND AND M HALLIDAY. 1981. RESPIRATORY CANCER IN A COHORT OF NICKEL SINTER PLANT WORKERS. BR J IND MED. 38. 327-333

ENTERLINE. PE AND GM MARSH. 1982. MORTALITY AMONG WORKERS IN A NICKEL REFINERY AND ALLOY MANUFACTURING PLANT IN WEST VIRGINIA J NAT
CANCER INST. 68: 925-933.

MAGNUS. K. A ANDERSEN AND A HOGETVEIT. 1982. CANCER OF RESPIRATORY ORGANS AMONG WORKERS AT A NICKEL REFINERY IN NORWAY INT J CANCER. 30:
681-685.

US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR NICKEL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROBENZENE 000098-95-3
010969 CUT. 1993. CHRONIC INHALATION TOXICITY STUDY OF NITROBENZENE IN B6C3F1 MICE. FISHER 344 RATS. AND SPRAGUE-DAWLEY CD RATS. CUT. PO BOX
12137. RESEARCH TRIANGLE PARK. NC. 27709.

US EPA. 1994. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)

R3-41
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

NITROFURAZONE 000059-87-0
005110 ERTURK. E. JE MORRIS. SM COHEN. ET AL. 1970. TRANSPLANTABLE RAT MAMMARY TUMORS INDUCED BY 5-NITRO-2-FURALOEHYDE SEMICARBAZONE AND BY
FORMIC ACID 2-[4-(5-NITRO-2-FURYL)-2-THIAZOLYL]HYDRAZIDE. CANCER RES. 30(5). 1409-1412

NITROPROPANE. 2- 000079-46-9
010142 LEWIS TR. CE ULRICH AND WM BUSEY. 1979. SUBCHRONIC INHALATION TOXICITY OF NITROMETHANE AND 2-NITROPROPANE J ENVIRON PATHOL TOXICOL
2(5): 233-249.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-NITROPROPANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2-NITROPROPANE PREPARED BY THE CARCINOGEN ASSESSMENT GROUP OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. WASHINGTON DC. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON DC

NITROSO-DI-N-BUTYLAMINE. N- 000924-16-3
010143 BERTRAM JS AND AW CRAIG. 1970. INDUCTION OF BLADDER TUMORS IN MICE WITH DIBUTYLNITROSAMINES. BR. J CANCER. 24: 352-359

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSO-DI-N-PROPYLAMINE. N- 000621-64-7
010147 DRUCKREY H. 1967. QUANTITATIVE ASPECTS IN CHEMICAL CARCINOGENS. IN. POTENTIAL CARCINOGENIC HAZARDS FROM DRUGS UICC MONOGRAPH SERIES 7
SPRINGER-VERLAG. BERLIN. P 60-78.

DRUCKREY H. R PURESSMAN. S IVANKOVIC AND D SCHMAHL. 1967. ORGANOTROPIC CARCINOGENIC EFFECT OF 65 DIFFERENT N-NITROSO COMPOUNDS ON BD
RATS. Z KREBSFORSCH. 69: 103-201.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-42
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

NITROSO-N-ETHYLUREA. N- 000759-73-9
010426 BULAY. 0. SS MIRVISH. H GARCIA. AF PELFRENE. B GOLD AND M EAGAN 1979 CARCINOGENICITY TESTS OF SIX NITROSAMIDES AND NITROSOCYANAMIDE
ADMINISTERED ORALLY TO RATS. J NATL CANCER INST 62: 1523-1528.

US EPA. 1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSO-N-ETHYLUREA IN SUPPORT OF REPORTABLE QUANTITY ADJUSTMENTS
PURSUANT TO CERCLA SECTION 102. PREPARED BY THE CARCINOGEN ASSESSMENT GROUP. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. WASHINGTON.
DC FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSO-N-METHYLUREA. N- 000684-93-5
010427 REDDY. JK AND MS RAO. 1975. PANCREATIC ADENOCARCINOMA IN INBRED GUINEA PIGS INDUCED BY N-METHYL-N-NITROSOUREA. CANCER RES. 35: 2269-2277.

US EPA. 1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSO-N-METHYLUREA IN SUPPORT OF REPORTABLE QUANTITY ADJUSTMENTS
PURSUANT TO CERCLA SECTION 102. PREPARED BY THE CARCINOGEN ASSESSMENT GROUP. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. WASHINGTON.
DC FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

US EPA. 1992. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSOOIETHANOLAMINE. N- 001116-54-7
010144 LIJINSKY W AND RM KOVATCH. 1985. INDUCTION OF LIVER TUMORS IN RATS BY NITROSODIETHANOLAMINE AT LOW DOSES. CARCINOGENESIS 6 1679-1681.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSODIETHYLAMINE. N- 000055-18-5
010145 PETO R. R GRAY. P BRANTOM AND P GRASSO. 1984. NITROSAMINE CARCINOGENESIS IN 5120 RODENTS. CHRONIC ADMINISTRATION OF 16 DIFFERENT
CONCENTRATIONS OF NDEA. NDMA. NPYR AND NPIP IN THE WATER OF 4440 INBRED RATS. WITH PARALLEL STUDIES ON NDEA ALONE OF THE EFFECT OF AGE OF
STARTING (3. 6 OR 20 WEEKS) AND OF SPECIES (RATS. MICE OR HAMSTERS). IARC SCI PUBL 57. 627-665.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-43
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

NITROSODIMETHYLAMINE. N- 000062-75-9
010146 PETO R. R GRAY. P BRANTQM AND P GRASSO. 1984. NITROSAMINE CARCINOGENESIS IN 5120 RODENTS. CHRONIC ADMINISTRATION OF 16 DIFFERENT
CONCENTRATIONS OF NDEA. NDMA. NPYR AND NPIP IN THE WATER OF 4440 INBRED RATS. WITH PARALLEL STUDIES ON NDEA ALONE OF THE EFFECT OF AGE OF
STARTING (3. 6 OR 20 WEEKS) AND OF SPECIES (RATS. MICE OR HAMSTERS). IARC SCI PUBL 57. 627-665

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

NITROSODIPHENYLAMINE. N- 000086-30-6
005112 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF N-NITROSODIPHENYLAMINE (CAS NO 86-30-6) FOR POSSIBLE CARCINOGENICITY. NCI
CARCINOGENESIS TECH REP SER NO 164. NIH 79-1720. NTIS PB 298-275.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR N-NITROSODIPHENYLAMINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSOMETHYLETHYLAMINE. N- 010595-95-6
010148 DRUCKREY H. 1967. QUANTITATIVE ASPECTS IN CHEMICAL CARCINOGENS. IN: POTENTIAL CARCINOGENIC HAZARDS FROM DRUGS. UICC MONOGRAPH. SERIES 7.
SPRINGER-VERLAG. BERLIN. P 60-78.

DRUCKREY H. R PURESSMAN. S IVANKOVIC AND D SCHMAHL. 1967. ORGANOTROPIC CARCINOGENIC EFFECT OF 65 DIFFERENT N-NITROSO COMPOUNDS ON BD
RATS. Z KREBSFORSCH. 69: 103-201.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-44
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
NITROSOMETHYLVINYLAMINE. N 004549-40-0
010149 ORUCKREY H. 1967. QUANTITATIVE ASPECTS IN CHEMICAL CARCINOGENS. IN. POTENTIAL CARCINOGENIC HAZARDS FROM DRUGS. UICC MONOGRAPH. SERIES 7.
SPRINGER-VERLAG. BERLIN. P 60-78.

DRUCKREY H. R PURESSMAN. S IVANKOVIC AND 0 SCHMAHL. 1967. ORGANOTROPIC CARCINOGENIC EFFECT OF 65 DIFFERENT N-NITROSO COMPOUNDS ON BD
RATS. I KREBSFORSCH. 69: 103-201.

US EPA. 1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSOMETHYLVINYLAMINE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON DC.

NITROSOPYRROLIDINE. N- 000930-55-2
010300 PREUSSMAN R. D SCHMAHL AND G EISENBRAND. 1977 CARCINOGENICITY OF N-NITROSOPYRROLIDINE: DOSE-RESPONSE STUDY IN RATS. Z KREBSFORSCH. 90:
161-166.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

PARATHION 000056-38-2
005116 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR PARATHION. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

PENTABROMO-6-CHLOROCYCLOHEXANE. 1.2.3.4.5- 000087-84-3
010150 BLAIR EH. 1981. TSCA SEC 8(E) SUBMISSION 8E HQ-0381-0393. 88-8100295 BY DOW CHEMICAL CO OFFICE OF TOXIC SUBSTANCES. US EPA. WASHINGTON.
DC.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2.3.4.5-PENTABROMO-6-CHLOROCYCLOHEXANE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON. DC.
R3-45
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

PENTACHLORONITROBENZENE 000082-68-8
010151 INNES. JRM. BM ULLAND. MG VALERIA. ET AL. 1969. BIOASSAY OF PESTICIDES AND INDUSTRIAL CHEMICALS FOR TUMORIGENICITY IN MICE- A PRELIMINARY
NOTE. J NATL CANCER INST. 41: 1101-1114.

PENTACHLOROPHENOL 000087-86-5
010381 NTP (NATIONAL TOXICOLOGY PROGRAM). 1989. TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF PENTACHLOROPHENOL (CAS NO
87-86-5) IN B6C3F1 MICE (FEED STUDIES). NTP TECH REPORT NO 349. NIH PUBL NO 89-2804

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

PHENYLENEDIAMINE. 0- 000095-54-5
010152 WEISBURGER EK. AB RUSSFIELD AND F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR
LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2(2). 325-356.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 0-PHENYLENEDIAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

PHENYLPHENOL. 2- 000090-43-7
010153 HIRAGA K AND U FUJII. 1981. INDUCTION OF TUMOURS OF THE URINARY SYSTEM IN F344 RATS BY DIETARY ADMINISTRATION OF SODIUM 0-PHENYLPHENATE
FOOD COSMET TOXICOL. 19(3): 303-310.

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-PHENYLPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

POLYBROMINATED BIPHENYLS
010154 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. CARCINOGENESIS STUDIES OF POLYBROMINATED BIPHENYL MIXTURE IN F344/N RATS AND B6C3F1 MICE (GAVAGE
STUDIES). FIREMASTER FF-1. CASE NO 67774-32-7. NTP. RESEARCH TRIANGLE PARK. NC

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR POLYBROMINATED BIPHENYLS (PBBS) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
R3-46
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
POLYCHLORINATED BIPHENYLS 001336-36-3
005118 NORBACK. DH. AND RH WELTMAN. 1985. POLYCHLORINATED BIPHENYL INDUCTION OF HEPATOCELLULAR CARCINOMA IN THE SPRAGUE-DAWLEY RAT ENVIRON
HEALTH PERSPECT. 60: 97-105.

US EPA 1990 DRINKING WATER CRITERIA DOCUMENT FOR POLYCHLORINATED BIPHENYLS (PCBS) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

PROPYLENE OXIDE 000075-56-9
010156 DUNKELBERG H. 1982. CARCINOGENICITY OF ETHYLENE OXIDE AND 1.2-PROPYLENE OXIDE UPON INTRAGASTRIC ADMINISTRATION TO RATS BR J CANCER. 46.
924-933.

US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPYLENE OXIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

010155 NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF PROPYLENE OXIDE (CAS NO 75-56-9) IN F344/N RATS AND
B6C3F1 MICE (INHALATION STUDIES). NTP TECH REP SER NO. 267. NTP. RESEARCH TRIANGLE PARK. NC NIH PUB NO 85-2527.

RENNE RA. WE GIDDENS. GA BOORMAN. R KOVATCH. JE HASEMAN AND WJ CLARKE 1986 NASAL CAVITY NEOPLASIA IN F344/N RATS AND (C57BL/6XC3H)F1
MICE INHALING PROPYLENE OXIDE FOR UP TO TWO YEARS. J NATL CANCER INST 77. 573-582

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

QUINOLINE 000091-22-5
010158 HIRAO K. Y SHINOHARA. H TSUDA. ET AL. 1976. CARCINOGENIC ACTIVITY OF QUINOLINE ON RAT LIVER CANCER RES. 36. 329-335

US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR QUINOLINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
R3-47
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY
Nay 1995
RDX / (CYCLONITE) 000121-82-4
010157 LISH PM. BS LEVINE. EM FUREDI. EM SAGARTZ AND VS RAC. 1984. DETERMINATION OF THE CHRONIC MAMMALIAN TOXICOLOGICAL EFFECT OF RDX: TWENTY
FOUR MONTH CHRONIC TOXICITY/CARCINOGENICITY STUDY OF HEXAHYDRA-1.2.5-TRINITRO-1.3.5-TRIAZINE (RDX) IN THE B6C3F1 HYBRID MOUSE. PHASE VI.
VOL 1. ITT RESEARCH INSTITUTE. CHICAGO. IL. US ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND. CONTRACT NO. DAMD 17-79-C-9161. NTIS
AD-A181766.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

SELENIUM SULFIDE 007446-34-6
010194 NCI/NTP (NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM). 1980. BIOASSAY OF SELENIUM SULFIDE (GAVAGE) FOR POSSIBLE
CARCINOGENICITY. NCI TECHNICAL REPORT SERIES NO. 194. NTP NO. 80-17.

US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELENIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

SIMAZINE 000122-34-9
010195 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SIMAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

SODIUM DIETHYLblTHIOCARBAMATE 000148-18-5
005126 BRL (BIONETICS RESEARCH LABORATORIES). 1968 EVALUATION OF CARCINOGENIC TERATOGENIC AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES ON
INDUSTRIAL CHEMICALS. VOL. I. CARCINOGENIC STUDY. PREPARED FOR NATIONAL CANCER INSTITUTE US DEPT COMMERCE. NAT TECH INFO SERV.
WASHINGTON. DC NTIS PB223159.

US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SODIUM DIETHYLDITHIOCARBAMATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

STYRENE 000100-42-5
010480 CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
R3-48
-------
REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY May 1995

TCDD. 2.3.7.8- 001746-01-6
005128 KOCIBA. RJ. DG KEYES. JE BOWER ET AL. 1978. RESULTS OF A TWO-YEAR CHRONIC TOXICITY AND ONCOGENICITY STUDY OF
2.3.7.8-TETRACHLOROOIBENZO-P-DIOXIN IN RATS TOXICOL APPL PHARMACOL 46(2). 279-303

US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR POLYCHLORINATED DIBENZO-P-DIOXIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. EPA 600/8-84-014F NTIS PB86-122546

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 2.3.7.8-TCDD. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

TETRACHLOROETHANE. 1.1.1.2- 000630-20-6
010302 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. CARCINOGENESIS STUDIES OF l.i,1.2-TETRACHLOROETHANE (CAS NO 630-20-6) IN F344/N RATS AND B6C3F1
MICE (GAVAGE STUDIES). NTP-81-53. NIH PUBL NO 83-1793. NTP TECHNICAL REPORT SERIES NO 237. NTIS. SPRINGFIELD. VA.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR 1.1.1.2-TETRACHLOROETHANE PREPARED BY THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF WATER.
WASHINGTON. DC.

TETRACHLOROETHANE. 1.1.2.2- 000079-34-5
005130 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1.1.2.2-TETRACHLOROETHANE FOR POSSIBLE CARCINOGEN1C1TY. NCI CARCINOGENESIS TECH REP
SER NO 27. DHEW NO (NIH) 78-827.

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

TETRACHLOROETHYLENE 000127-18-4
010482 CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
R3-49
-------
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
TETRACHLOROTOLUENE. PARA. ALPHA. ALPHA. ALPHA- 005216-25-1
005028 FUKADA. KS. MATSASHITA AND K TAKEMOTO. 1979. CARCINOGENICITY OF P-CHLOROBENZOTRICHLORIDE PROC OF JAPAN ASSOC OF IND HEALTH P 330-331.

US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED CHLORINATED TOLUENES PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.

TETRACHLOROVINPHOS / (STIROFOS) 000961-11-5
010159 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF TETRACHLOROVINPHOS FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH REP SER NO. 33
NTIS PB278650.

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

TOLUENE-2.4-DIAMINE 000095-80-7
010160 NCI (NATIONAL CANCER INSTITUTE). 1979 BIOASSAY OF 2.4-DIAMINOTOLUENE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH REP SER NO. 162.

US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-TOLUENEDIAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

TOLUIDINE. P- 000106-49-0
010162 WEISBURGER EK. AB RUSSFIELD AND F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR
LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2(2). 325-356

US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIDINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

TOXAPHENE 008001-35-2
005134 LITTON BIONETICS. INC. 1978. CARCINOGENIC EVALUATION IN MICE: TOXAPHENE PREPARED BY LITTON BIONETICS. INC.. KENSINGTON. MD FOR HERCULES.
INC. WILMINGTON. DE. LBI PROJECT NO. 20602.

US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TOXAPHENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR TOXAPHENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

R3-50
-------
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995

TRICHLOROANILINE HYDROCHLORIDE. 2.4.6- 033663-50-2
005142 WEISBURGER. EL. AB RUSSFIELD. R HOMBURGER. ET AL 1978. TESTING OF 21 ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM TOXICITY
OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2- 325-356.

US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROANILINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

TRICHLOROANILINE. 2.4.6- 000634-93-5
010487 WEISBURGER. EL. AB RUSSFIELD. F HOMBURGER. ET AL. 1978. TESTING OF 21 ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG TERM TOXICITY
OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

TRICHLOROETHANE. 1.1.2- 000079-00-5
005144 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1.1.2-TRICHLOROETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO
74. DHEW NO NIH 78-1324.

US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1.1.2-TRICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC. '

US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

TRICHLOROETHYLENE 000079-01-6
010483 CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
R3-51
-------
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY
Hay 1995
TRICHLOROPHENOL. 2.4.6-
010428 NCI (NATIONAL CANCER INSTITUTE).
155. OHEW NO NIH 79-1711.
000088-06-2
1979. BIOASSAY OF 2.4.6-TRICHLOROPHENOL FOR POSSIBLE CARCINOGENICITY.
NCI CARCINOGENESIS TECH REP SER NO
US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
DC.

US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR 2.4.6-TRICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

TRICHLOROPROPANE. 1.2,3- 000096-18-4
010849 NTP (NATIONAL TOXICOLOGY PROGRAM). 1991. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.2.3-TRICHLOROPROPANE (CAS
NO 96-18-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). BOARD DRAFT NTP TR 384 NIH PUB NO 91-2839 US DEPT OF HEALTH AND HUMAN
SERVICES. PUBLIC HEALTH SERVICE. NIH. RESEARCH TRIANGLE PARK. NC.

US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

TRIFLURALIN 001582-09-8
010163 EMMERSON JL EC PIERCE JP MCGRATH. ET AL. 1980. THE CHRONIC TOXICITY OF COMPOUND 36352 (TRIFLURALIN) GIVEN AS A COMPOUND OF THE DIET TO
FISCHER 344 RATS FOR TWO YEARS. STUDIES R-87 AND R-97 (UNPUBLISHED STUDY RECEIVED SEPTEMBER 18. 1980 UNDER 1471-35. SUBMITTED BY ELANCO
PRODUCTS CO.. DIVISION OF ELI LILLY AND CO.. INDIANAPOLIS. IN).

US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-52
-------
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
TRIMETHYL PHOSPHATE 000512-56-1
010164 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF TRIMETHYLPHOSPHATE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH REP SER NO. 81.

US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIMETHYL PHOSPHATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

TRINITROTOLUENE. 2.4.6- 000118-96-7
010476 US DOD (DEPARTMENT OF DEFENSE). 1984. AD-A168637. DEFENSE TECHNICAL CENTER. CAMERON STATION. ALEXANDRIA. VA.

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2.4.6-TRINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.

US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-53
-------
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY May 1995
VINYL CHLORIDE 000075-01-4
010368 FERON. VJ. CFM HENORIKSEN. AJ SPEEK. ET AL. 1981. LIFESPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS. FOOD COSMET TOXICOL. 19(3):
317-333.

US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR VINYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

US EPA 1985 DRINKING WATER CRITERIA DOCUMENT FOR VINYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

010367 MALTONI C G LEFEMINE A CILIBERTI ET AL 1980 VINYL CHLORIDE CARCINOGENICITY BIOASSAYS (BT PROJECT) AS AN EXPERIMENTAL MODEL FOR RISK
IDENTIFICATION AND ASSESSMENT IN ENVIRONMENTAL AND OCCUPATIONAL CARCINOGENESIS EPIDEMIOL ANIM EPIDEMIOL HUM: CAS CHLORURE VINYLE
MONOMERE. (REUN CLUB CANCEROG CHIM). 20TH. MEETING DATE 1979. P. 11-112 PUBL ESSENT. PARIS. FRANCE.

MALTONI. C. G LEFEMINE. A CILIBERTI ET AL. 1981 CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE MONOMER. A MODEL OF RISK ASSESSMENT ON AN
EXPERIMENTAL BASIS. ENVIRON HEALTH PERSPECT 41: 329.

US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROETHENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

US EPA. 1994. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-54
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Table 4

Radionuclide Carcinogencity - Slope Factors
(In Units of Picocuries)

MAY 1995
NOTE: To convert radionuclide slope factors into the International System (SI)
activity units of becquerels (Bq), multiply each value in Table 4 by 3.70E-02.
-------
Table 4: Radionuclide Carcinogenicity -- Slope Factors3 MAY 1995
(In Units of Picocuriesb)
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Actinium (89)

Americium (95)

Antimony (51)

Argon (18)
Isotope'
Ac-225
Ac-227
Ac-227+D
Ac-228
Am-241
Am-242
Am-242m
Am-243
Am-243+D
Sb-122
Sb-124
Sb-125
Sb-125+D
Sb-126
Sb-126m
Sb-127
Sb-129
Ar-41
CASRN*
014265-85-1
014952-40-0
014952-40-0(^0)
014331-83-0
014596-10-2
013981-54-9
013981-54-9(m)
014993-75-0
014993-75-0(+D)
014374-79-9
014683-10-4
014234-35-6
014234-35-6(+D)
015756-32-8
015756-32-8(m)
013968-50-8
014331-88-5
014163-25-8
Radioactive
Hart-life*
1.00E+01
2.18E+01
2.18E+01
6.13E+00
4.32E+02
1.60E+01
1.52E+02
7.38E+03
7.38E+03
2.70E+00
6.02E+01
2.77E+00
2.77E+00
1.24E+01
1.90E+01
3.85E+00
4.40E+00
1.83E+00
D
Y
Y
H
Y
H
Y
Y
Y
D
D
Y
Y
D
M
D
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
W
W
W
*
Gl
Absorption
Factor (f,)s
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
—
Ingestion
(Risk/pCi)
1.42E-10
352E-10
6.26E-10
1 62E-12
3.28E-10
1 47E-12
2 92E-10
3 27E-10
3.31E-10
8.81E-12
1.07E-11
2.97E-12
354E-12
9.73E-12
7.28E-14
8.48E-12
1 86E-12
—
Inhalation
(Risk/pCi)
4.16E-09
7.08E-08
7.87E-08
3.27E-11
3.85E-08
1.04E-11
3.49E-08
3.82E-08
3.82E-08
5.46E-12
1.32E-11
5.20E-12
5.85E-12
8.41 E-1 2
6.43E-14
6.05E-12
8.60E-13
4.71E-16
External Exposure
(Risk/yr per pCI/g soil)
7.81 E-09
2.35E-11
5.97E-07
3.28E-06
4.59E-09
5 76E-09
8.76E-11
2.43E-08
2.66E-07
1.61E-06
7.35E-06
1.34E-06
1.34E-06
1 .03E-05
5.78E-06
2.40E-06
5.56E-06
—
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors2
(In Units of Picocuriesb)
MAY 1995
Element
(Atomic Number)
Astatine (85)
Barium (56)

Beryllium (4)
Bismuth (83)

Bromine (35)
Cadmium (20)

Isotope0
At-217
Ba-131
Ba-133
Ba-133m
Ba-137m
Ba-139
Ba-140
Be-7
Bi-206
Bi-207
Bi-210
Bi-211
Bt-212
Bi-213
Bi-214
Br-82
Cd-109
Cd-115
CASRN"
017239-90-6
014914-75-1
013981-41-4
013981-41-4(m)
013981-97-0(m)
014378-25-7
0147984)8-4
0139664)2-4
015776-19-9
013982-38-2
014331-79-4
015229-37-5
014913-494)
015776-20-2
014733-03-0
014686-69-2
014109-32-1
014336-68-6
Radioactive
Half-life*
3.23E-02
1.18E+01
1.05E+01
3.89E+01
2.55E+00
8.31 E+01
1.28E+01
5.34E+01
6.24E+00
3.34E+01
5.01 E+00
2.13E+00
6.06E+01
4.57E+01
1.99E+01
3.53E+01
4.64E+02
5.35E+01
S
D
Y
H
M
M
D
D
D
Y
D
M
M
M
M
H
D
H
ICRP
Lung
Class'
0
0
D
D
D
D
D
Y
W
W
W
W
W
W
W
D
Y
Y
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Gl
Absorption
Factor (f,)8
9.50E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
5.00E-03
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
9.50E-01
5.00E-02
5.00E-02
Ingestion
(Risk/pCi)
899E-18
1 70E-12
2 70E-12
2 76E-12
243E-15
3.04E-13
1 18E-11
8.64E-14
7.11E-12
5.05E-12
7.29E-12
1.82E-14
620E-13
440E-13
1.95E-13
1.42E-12
8.01E-12
7 29E-12
Inhalation
(Risk/pCi)
5.14E-16
4.79E-13
4.03E-12
5.60E-13
1.57E-15
1.53E-13
3.17E-12
1.78E-13
5.07E-12
9.42E-12
5.12E-11
1.74E-12
3.65E-11
3.09E-1 1
1.46E-11
7.86E-13
1.85E-11
4.93E-12
External Exposure
(Risk/yr per pCi/g soil)
8.71E-10
1 27E-06
9 15E-07
1 .OOE-07
221E-06
8.35E-08
6.00E-07
1.73E-07
1.20E-05
5.49E-06
O.OOE+0
1 48E-07
6.67E-07
4.62E-07
6 02E-06
101E-05
5.62E-10
7.02E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)

Calcium (20)

Carbon (6)

Cerium (58)

Cesium (55)

Isotope0
Cd-115m
Ca-45
Ca-47
C-11
C-14
C-15
Ce-141
Ce-143
Ce-144
Ce-144+D
Cs-131
Cs-134
Cs-134m
Cs-135
Cs-136
Cs-137
Cs-137+D
Cs-138
CASRN"
014336-68-6(m)
013966-05-7
001439-99-2
014333-33-6
014762-75-5
015929-23-4
013967-74-3
014119-19-8
014762-78-8
014762-78-8(+D)
014914-76-2
013967-70-9
013967-70-9(m)
015726-30-4
014234-29-8
010045-97-3
010045-97-3(+D)
015758-29-9
Radioactive
Half-life*
4.46E+01
1.63E+02
4.54E+00
2.05E+01
5.73E+03
2.45E+00
3.25E+01
3.30E+01
2.84E+02
2.84E+02
9.69E+00
2.06E+00
2.90E+00
2.30E+06
1.32E+01
3.02E+01
3.02E+01
3.22E+01
D
D
D
M
Y
S
D
H
D
D
D
Y
H
Y
D
Y
Y
M
ICRP
Lung
Class'
Y
W
W
D
*
D
Y
Y
Y
Y
D
D
O
D
D
D
D
D
Gl
Absorption
Factor (f,)g
5.00E-02
3.00E-01
3.00E-01
9.50E-01
1.00E+00
- 9.50E-01
3.00E-04
3.00E-04
3.00E-04
3.00E-04
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
Ingestion
(Risk/pCi)
1.42E-11
2.02E-12
6.66E-12
4.49E-14
1.03E-12
6 62E-16
391E-12
591E-12
2 96E-1 1
2 97E-1 1
1 80E-13
4 73E-1 1
4.54E-14
4.53E-12
7.74E-12
3.16E-11
316E-11
1.76E-13
Inhalation
(Risk/pCi)
1.70E-11
2.51E-12
5.22E-12
3.38E-14
6.99E-15
8.06E-16
4.32E-12
3.84E-12
1.08E-10
1.08E-10
1.06E-13
2.89E-1 1
3.10E-14
2.71E-12
4.65E-12
1.91E-11
1.91E-11
1.30E-13
External Exposure
(Risk/yr per pCi/g soil)
8.55E-08
388E-18
4.12E-06
3.61 E-06
OOOE+0
—
1.41E-07
7.32E-07
2.58E-08
1.56E-07
2.34E-09
5.88E-06
1.96E-08
O.OOE+0
8.13E-06
O.OOE+0
2.09E-06
9.45E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Chlorine (17)

Chromium (24)
Cobalt (27)

Copper (29)
Curium (96)

Dysprosium (66)

Isotope0
CI-36
CI-38
Cr-51
Co-57
Co-58
Co-58m
Co-60
Cu-64
Cm-242
Cm-243
Cm-243+D
Cm-244
Cm-245
Cm-246
Cm-247
Cm-248
Dy-165
Dy-166
CASRN"
013981-43-6
014158-34-0
014392-02-0
013981-50-5
01381-38-9
01381-38-9(m)
010198-40-0
013981-25-4
015510-73-3
015757-87-6
015757-87-6(+D)
013981-15-2
015621-76-8
015757-90-1
015758-32-4
015758-33-5
013967-64-1
015840-01-4
Radioactive
Half-life*
3.01 E+05
3.72E+01
2.77E+01
2.71 E+02
7.08E+01
9.15E+00
5.27E+00
1.27E+01
1.63E+02
2.85E+01
2.85E+01
1.81E+01
8.50E+03
4.75E+03
1.56E+07
3.39E+05
2.33E+00
8.16E+01
Y
M
D
D
D
H
Y
H
D
Y
Y
Y
Y
Y
Y
Y
H
H
ICRP
Lung
Class*
D
D
Y
Y
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)B
9.50E-01
9.50E-01
1.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
5.00E-01
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
3.00E-04
3.00E-04
Ingestion
(Risk/pCi)
2.23E-12
2 07E-13
1 38E-13
9.71E-13
282E-12
9.46E-14
1.89E-11
525E-13
383E-11
251E-10
2.52E-10
2.11E-10
3.35E-10
3.32E-10
309E-10
1 31E-09
3.26E-13
9.42E-12
Inhalation
(Risk/pCi)
1.30E-12
1.63E-13
1.74E-13
2.88E-12
5.17E-12
8.90E-14
6.88E-11
4.18E-13
3.16E-09
2.89E-08
2.90E-08
2.43E-08
3.92E-08
3.90E-08
3.58E-08
1.46E-07
2.24E-13
7.82E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
6.47E-06
1.02E-07
2.07E-07
3.73E-06
3.21E-11
976E-06
6.72E-07
2.34E-11
1.71E-07
1.72E-07
2.07E-11
5.51 E-08
1.81E-11
1.03E-06
1.47E-11
6.18E-08
2.72E-08
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors3
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Erbium (63)

Europium (63)

Fluorine (9)
Francium (87)

Gadolinium (64)

Gallium (31)

Germanium (32)
Gold (79)

Holmium (67)
Hydrogen (1)
Isotope'
Er-169
Er-171
Eu-152
Eu-154
Eu-155
Eu-156
F-18
Fr-221
Fr-223
Gd-153
Gd-159
Ga-67
Ga-72
Ge-71
Au-196
Au-198
Ho-166
H-3
CASRN"
015840-13-8
014391-45-8
014683-23-9
015585-10-1
014391-16-3
014280-35-4
013981-56-1
015756-41-9
015756-98-6
014276-65-4
014041-42-0
014119-09-6
013982-22-4
014374-81-3
014914-16-0
010043-49-0
013967-65-2
010028-17-8
Radioactive
Half-life*
9.40E+00
7.52E+00
1.36E+01
8.80E+00
4.96E+00
1.52E+01
1.10E+02
4.80E+00
2.18E+00
2.42E+02
1.86E+01
3.26E+00
1.41E+01
1.18E+01
6.18E+00
2.70E+00
2.68E+01
1.23E+01
D
H
Y
Y
Y
D
M
M
M
D
H
D
H
D
D
D
H
Y
ICRP
Lung
Class*
W
W
W
W
W
W
D
D
D
W
W
W
W
W
Y
Y
W
V
Gl
Absorption
Factor (f,)9
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1.00E-03
1.00E-03
9.50E-01
9.50E-01
9.50E-01
3.00E-04
3.00E-04
1.00E-03
1.00E-03
9.50E-01
1.00E-01
1.00E-01
3.00E-04
1.00E+00
IngesUon
(Risk/pCi)
2.12E-12
1 63E-12
5 73E-12
9 37E-12
1.65E-12
1.09E-11
1.09E-13
1.45E-13
4.46E-13
1.32E-12
2.60E-12
8.36E-13
4 77E-12
1.18E-14
130E-12
528E-12
7 57E-12
7.15E-14
Inhalation
(Risk/pCi)
1.51E-12
7.50E-13
7.91 E-11
9.15E-11
9.60E-12
9.26E-12
6.54E-14
8.02E-12
5.90E-13
3.20E-12
1.24E-12
5.14E-13
2.17E-12
5.84E-14
1.04E-12
3.64E-12
4.06E-12
9.59E-14
External Exposure
(Risk/yr per pCI/g soil)
6.52E-12
1.04E-06
4.08E-06
4.65E-06
6.08E-08
5.40E-06
3.50E-06
6.74E-08
4.17E-08
7.22E-08
9.59E-08
3.61 E-07
1.12E-05
1.56E-11
1.41E-06
1.37E-06
6.96E-08
O.OOE+0
(Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors8 MAY 1995
(In Units of Picocuries5)
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Indium (49)

Iodine (53)

Indium (77)

Isotope0
ln-1 13m
ln-114
ln-114m
ln-115
ln-115m
1-122
1-123
1-125
1-126
1-129
1-130
1-131
1-132
1-133
1-134
1-135
lr-190
lr-194
CASRN"
014885-78-0(m)
013981-55-0
013981-55-0(m)
014191-71-0
014191-71-0(m)
018287-75-7
015715-08-9
014158-31-7
014158-32-8
015046-84-1
014914-02-4
010043-66-0
014683-16-0
014834-67-4
014914-27-3
014834-68-5
014981-91-0
014158-35-1
Radioactive
Half-life*
1.66E+00
7.19E+01
4.95E+01
4.606+15
4.36E+00
3.62E+00
1.31E+01
6.01 E+01
1.29E+01
1.57E+07
1.24E+01
8.04E+00
2.30E+00
2.08E+01
5.26E+01
6.61 E+00
1.18E+01
1.92E+01
H
S
D
Y
H
M
H
D
D
Y
H
D
H
H
M
H
D
H
ICRP
Lung
Class'
W
W
W
W
W
D
D
D
D
D
D
D
D
D
D
D
Y
Y
Gl
Absorption
Factor (f,)8
2.00E-02
2.00E-02
2.00E-02
200E-02
2.00E-02
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
1.00E-02
1.00E-02
Ingestion
(Risk/pCi)
8 30E-14
4.53E-15
206E-11
349E-11
3.42E-13
2.16E-14
5.42E-13
2.58E-11
4.82E-11
1.84E-10
4.85E-12
362E-11
6.62E-13
106E-11
2.31E-13
2.27E-12
4 95E-12
7 OOE-12
Inhalation
(Risk/pCi)
5.77E-14
5.81E-15
2.53E-11
2.07E-10
1.75E-13
2.24E-14
2.94E-13
1.71E-11
3.15E-11
1.22E-10
2.61E-12
2.33E-11
3.52E-13
6.02E-12
1.38E-13
1.18E-12
4.49E-12
4.18E-12
External Exposure
(Risk/yr per pCi/g soil)
7.82E-07
1.13E-07
200E-07
O.OOE+0
4.29E-07
341E-06
2.52E-07
2.39E-09
1.49E-06
2.69E-09
7.93E-06
1.25E-06
8.75E-06
220E-06
1.02E-05
6.23E-06
4.65E-06
3.17E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Element
(Atomic Number)
Iron (26)

Krypton (36)

Lanthanum (57)
Lead (82)

Lutetium(71)
Isotope0
Fe-55
Fe-59
Kr-83m
Kr-85
Kr-85m
Kr-87
Kr-88
Kr-89
Kr-90
La-140
Pb-203
Pb-209
Pb-210
Pb-210+D
Pb-211
Pb-212
Pb-214
Lu-177
CASRN"
014681-59-5
014596-12-4
013965-98-5(m)
013983-27-2
013983-27-2(m)
014809-68-8
014995-61-0
016316-03-3
015741-13-6
013981-28-7
014687-25-3
014119-30-3
014255-04-0
014255-04-0(+D)
015816-77-0
015092-94-1
015067-28-4
014265-75-9
Radioactive
Half-life*
2.70E+00
4.46E+01
1.83E+00
1.07E+01
4.48E+00
7.63E+01
2.84E+00
3.16E+00
3.23E+01
4.02E+01
5.20E+01
3.25E+00
2.23E+01
2.23E+01
3.61 E+01
1.06E+01
2.68E+01
6.71 E+00
Y
D
H
Y
H
M
H
M
S
H
H
H
Y
Y
M
H
M
D
ICRP
Lung
Class'
W
w
*
*
*
*
*
*
*
w
D
D
D
D
D
D
D
Y
Gl
Absorption
Factor (f,)a
1.00E-01
1.00E-01
--
—
--
--
—
--
—
1.00E-03
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
3.00E-04
Lifetime Excess
Ingestion
(Risk/pCi)
351E-13
5 87E-12
—
—
—
—
—
—
—
9.46E-12
1.03E-12
2.09E-13
6.75E-10
1 01E-09
338E-13
180E-11
294E-13
2.95E-12
Slope Factor
Total Cancer Risk Per Unit Intake or Exposure
Inhalation
(Risk/pCi)
5.60E-13
7.08E-12
3.48E-17
2.87E-16
2.75E-16
1.20E-15
2.20E-15
1.61E-15
1.60E-15
5.10E-12
3 10E-13
6.85E-14
1.67E-09
3.86E-09
1.03E-11
3.85E-11
6.23E-12
2.20E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
4 63E-06
—
—
—
—
--
--
_
9.11E-06
6.40E-07
O.OOE+0
1.12E-10
1.45E-10
1.85E-07
3.00E-07
7.09E-07
7.22E-08
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Manganese (25)

Mercury (80)

Molybdenum (42)
Neodymium (60)

Neptunium (93)

Nickel (28)

lsotopec
Mn-52
Mn-54
Mn-56
Hg-197
Hg-203
Mo-99
Nd-147
Nd-149
Np-236
Np-237
Np-237+D
Np-238
Np-239
Np-240
Np-240m
Ni-59
Ni-63
Ni-65
CASRN"
014092-99-0
013966-31-9
014681-52-8
013981-51-6
013982-78-0
014119-15-4
014269-74-0
015749-81-2
015700-36-4
013994-20-2
013994-20-2(+D)
015766-25-3
013968-59-7
015690-84-3
015690-84-3(m)
014336-70-0
013981-37-8
014833-49-9
Radioactive
Half-life*
5.59E+00
3.13E+02
2.58E+00
6.41 E+01
4.66E+01
6.60E+01
1.10E+01
1.73E+00
1.15E+05
2.14E+06
2.14E+06
2.12E+00
2.36E+00
6.50E+01
7.40E+00
7.50E+04
1.00E+02
2.52E+00
D
D
H
H
D
H
D
H
Y
Y
Y
D
D
M
M
Y
Y
H
ICRP
Lung
Class'
W
W
W
W
W
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)fl
1.00E-01
1.00E-01
1.00E-01
2.00E-02
2.00E-02
8.00E-01
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
5.00E-02
5.00E-02
5.00E-02
Ingestion
(Risk/pCi)
601E-12
1.96E-12
8.57E-13
1.18E-12
2.64E-12
2.27E-12
5.88E-12
4.55E-13
9.31E-13
2.95E-10
3.00E-10
4.56E-12
427E-12
1 77E-13
242E-14
1.85E-13
5.50E-13
562E-13
Inhalation
(Risk/pCi)
4 40E-12
3.69E-12
5.21E-13
6.95E-13
3.03E-12
4.48E-12
4.84E-12
4.22E-13
3.87E-12
3.45E-08
3.45E-08
4.68E-12
2.41E-12
1.31E-13
2.83E-14
4.01E-13
1.01E-12
3.59E-13
External Exposure
(Risk/yr per pCI/g soil)
1.34E-05
3.26E-06
6.95E-06
5.47E-08
6.27E-07
5.46E-07
3.22E-07
1.08E-06
922E-08
7.56E-09
4.62E-07
1.95E-06
2.42E-07
365E-06
1 05E-06
O.OOE+0
O.OOE+0
2.14E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page ]
-------
Table 4: Radionuclide Carcinogenicity -- Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Niobium (41)

Osmium (76)

Palladium (46)

Phosphorus (15)

Platinum (78)
Isotope0
Nb-93m
Nb-94
Nb-95
Nb-95m
Nb-97
Nb-97m
Os-185
Os-191
Os-191m
Os-193
Pd-100
Pd-101
Pd-103
Pd-107
Pd-109
P-32
P-33
Pt-191
CASRN"
007440-03-1(m)
014681-63-1
013967-76-5
013967-76-5(m)
018496-04-3
018496-04-3(m)
015766-50-4
014119-24-5
014119-24-5(m)
016057-77-5
015690-69^1
015749-54-9
014967-68-1
017637-99-9
014981-64-7
014596-37-3
015749-66-3
015706-36-2
Radioactive
Half-life*
1.46E+01
2.03E+04
3.51 E+01
8.66E+01
7.21 E+01
6.00E+01
9.36E+01
1.54E+01
1.30E+01
3.00E+01
3.64E+00
8.48E+00
1.70E+01
6.50E+06
1.35E+01
1.43E+01
2.54E+01
2.71 E+00
Y
Y
D
H
M
S
D
0
H
H
D
H
D
Y
H
D
D
O
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
D
D
D
Gl
Absorption
Factor (f,)a
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
5.00E-03
5.00E-03
5.00E-03
5.00E-03
5.00E-03
8.00E-01
8.00E-01
1.00E-02
Ingestion
(Risk/pCi)
6.64E-13
691E-12
2.25E-12
3.06E-12
1.75E-13
327E-15
1.80E-12
3.04E-12
4 95E-13
4 36E-12
3 74E-12
3 74E-13
1.05E-12
2 09E-13
3.33E-12
611E-12
781E-13
1 50E-12
Inhalation
(Risk/pCi)
4.33E-12
8.20E-11
3.11E-12
2.25E-12
2.13E-13
3.34E-15
4.62E-12
2.70E-12
3.32E-13
2.68E-12
3.55E-12
2.29E-13
1.08E-12
1.46E-12
1.99E-12
2.93E-12
3.96E-13
4.13E-13
External Exposure
(Risk/yr per pCI/g soil)
3.64E-11
6.08E-06
2.94E-06
8.71 E-08
2.49E-06
2.78E-06
2.45E-06
8.74E-08
3.22E-09
1 .82E-07
_.
_
5.38E-10
O.OOE+0
2 43E-09
O.OOE+0
0 OOE+0
6.74E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
10
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors3
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Pt-193
Pt-193m
Pt-197
Pt-197m
Plutonium (94) Pu-236
Pu-238
Pu-239
Pu-240
Pu-241
Pu-241+D
Pu-242
Pu-243
Pu-244
Pu-244+D
Polonium (84) Po-210
Po-212
Po-213
Po-214
CASRN"
015735-70-3
015735-70-3(m)
015735-74-7
015735-74-7(m)
015411-92-4
013981-16-3
015117-48-3
014119-33-6
014119-32-5
014119-32-5(+D)
013982-10-0
015706-37-3
014119-34-7
014119-34-7(+D)
013981-52-7
015389-34-1
015756-57-7
01573W7-8
Radioactive
Half-life*
5.00E+01
4.33E+00
1.83E+01
9.44E+01
2.85E+00
8.78E+01
2.41 E+04
6.57E+03
1.44E+01
1.44E+01
3.76E+05
4.96E+00
8.26E+07
8.26E+07
1.38E+02
2.98E-07
4.20E-06
1.64E-04
Y
D
H
M
Y
Y
Y
Y
Y
Y
Y
H
Y
Y
D
S
S
S
ICRP
Lung
Class'
D
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
W
61
Absorption
Factor (f,)a
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-01
1.00E-01
1.00EX)1
1.00E-01
Ingestion
(Risk/pCi)
1.62E-13
2.51E-12
2.12E-12
325E-13
7.68E-11
295E-10
316E-10
3.15E-10
520E-12
333E-10
300E-10
369E-13
3.13E-10
3.19E-10
326E-10
4.51 E-23
670E-22
2.12E-20
Inhalation
(Risk/pCi)
7.89E-14
5.76E-13
4.54E-13
1.00E-13
1.34E-08
2.74E-08
2.78E-08
2.78E-08
281E-10
3.88E-08
264E-08
2.67E-13
2.67E-08
2.67E-08
214E-09
5.93E-21
7.80E-20
2.77E-18
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
7.44E-09
3.15E-08
1.65E-07
232E-11
1.94E-11
1.26E-11
1.87E-11
OOOE+0
4.59E-09
1.55E-11
1 89E-08
1.29E-11
3.65E-06
3.30E-11
O.OOE+0
1.18E-10
3.23E-10
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
11
-------
Table 4: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)

Potassium (19)

Praseodymium (59)

Promethium(61)

Protactinium (91)

Radium (88)
Isotope'
Po-215
Po-216
Po-218
K-40
K-42
Pr-142
Pr-143
Pr-144
Pr-144m
Pm-147
Pm-148
Pm-148m
Pm-149
Pa-231
Pa-233
Pa-234
Pa-234m
Ra-223
CASRNd
015706-52-2
015756-58-8
015422-24-9
013966-00-2
014378-21-3
014191-64-1
014981-79-4
014119-05-2
014119-05-2(m)
014380-75-7
014683-19-3
01 4683-1 9-3(m)
015765-31-8
014331-85-2
013981-14-1
015100-28-4
015100-28-4(m)
015623-45-7
Radioactive
Half-life*
1.78E-03
1.46E-01
3.05E+00
1.28E+09
1.24E+01
1.91E+01
1.36E+01
1.73E+01
7.20E+00
2.62E+00
5.37E+00
4.13E+01
5.31 E+01
3.73E+04
2.70E+01
6.70E+00
1.17E+00
1.14E+01
S
S
M
Y
H
H
D
M
M
Y
D
D
H
Y
D
H
M
D
ICRP
Lung
Class'
W
W
W
0
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
Gl
Absorption
Factor (f,)8
1.00E-01
1.00E-01
1.00E-01
9.50E-01
9.50E-01
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1.00E-03
1.00E-03
2.00E-01
Ingestion
(Risk/pCi)
499E-19
8 79E-17
5.08E-14
1.25E-11
1.29E-12
6 98E-12
6 60E-12
8.08E-14
3.23E-14
141E-12
1.44E-11
9.93E-12
5.52E-12
1.49E-10
469E-12
2.13E-12
4 77E-15
2.34E-10
Inhalation
(Risk/pCi)
4.48E-17
2.95E-15
369E-12
7.46E-12
7.56E-13
4.16E-12
5.60E-12
1.31E-13
5.61 E-14
7.49E-12
1.05E-11
2.95E-11
3.57E-12
2.42E-08
4.92E-12
1.30E-12
6.27E-15
3.60E-09
External Exposure
(Risk/yr per pCI/g soil)
511E-10
562E-11
O.OOE+0
6.11E-07
1.09E-06
2.34E-07
3.41E-14
1.33E-07
1 85E-09
6.35E-12
2.21 E-06
7.32E-06
3.65E-08
2 71E-08
4 54E-07
6.60E-06
4.05E-08
2.44E-07
(Table 4 continues on the following page: Refer to Endnotes on the last page.]
12
-------
Table 4: Radionuclide Carcinogenicity -- Slope Factors8 MAY 1995
(In Units of Picocuries5)
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0

Radon (86)

Rhodium (45)

Ra-224
Ra-225
Ra-226
Ra-226+D
Ra-228
Ra-228+D
Rn-219
Rn-220
Rn-222+D1
Rh-103m
Rh-105
Rh-105m
Rh-106
CASRN"
013233-32-4
013981-53-8
013982-63-3
013982-63-3(+D)
015262-20-1
01 5262-20-1 (+D)
014835-02-0
022481-48-7
014859-67-7(+D)
007440-16-6(m)
014913-89-4
014913-89-4(m)
014234-34-5
ICRP
Radioactive Lung
Half-life* Class'
3.62E+00
1.48E+01
1.60E+03
1.60E+03
5.75E+00
5.75E+00
3.96E+00
5.56E+01
3.82E+00
5.61 E+01
3.54E+01
4.50E+01
D
D
Y
Y
Y
Y
S
S
D
M
H
S
W
W
W
W
W
W
*
*
*
Y
Y
Y
Gl
Absorption
Factor (f,)°
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
—
--
—
5.00E-02
5.00E-02
5.00E-02
Ingestion
(Risk/pCi)
1 49E-10
1 57E-10
2.95E-10
2.96E-10
2.46E-10
2.48E-10
—
—
--
8.19E-15
1 93E-12
1 08E-15
Inhalation External Exposure
(Risk/pCI) (Risk/yr per pCi/g soil)
2.25E-09
2.38E-09
2.72E-09
2.75E-09
961E-10
9.94E-10
6.91E-14
1.92E-13
7.57E-12
1.28E-14
1.22E-12
9 25E-16
2.48E-08
1.71E-09
1.31E-08
6.74E-06
0 OOE+0
3 28E-06
1.72E-07
1.88E-09
—
5.85E-11
2 49E-07
2.27E-08
2.99E+01 S Y 5.00E-02 363E-15 4.62E-15 7.57E-07
1 To derive the inhalation slope factor for Rn-222+D, EPA's Office of Radiation and Indoor Air (OR1A) uses a slightly different risk model and set of
exposure assumptions, including an inhalation rate of 2.2E+04 L/day; 50% equilibrium for decay products; and a risk coefficient of 2.36E-4 cases per working
level month (WLM). A more detailed description of ORIA's radon risk assessment methodology is provided in the EPA CRAVE Summary Sheet, Inhaled Rn-
222 and its Short Half-Life Decay Products.
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
13
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Element
(Atomic Number)
Rubidium (37)

Ruthenium (44)

Samarium (62)

Scandium (21)

Selenium (34)
Silicon (14)
Isotope'
Rb-82
Rb-86
Rb-87
Rb-88
Rb-89
Ru-97
Ru-103
Ru-105
Ru-106
Ru-106+D
Sm-147
Sm-151
Sm-153
So46
Sc-47
Sc-48
Se-75
Si-31
CASRN"
014391-63-0
014932-53-7
013982-13-3
014928-36-0
014191-65-2
015758-35-7
013968-53-1
014331-95-4
013967-48-1
013967-48-1(4-0)
014392-33-7
015715-94-3
015766-00-4
013967-63-0
014391-96-9
014391-86-7
014265-71-5
014276-49-4
Radioactive
Half-life*
1.25E+00
1.87E+01
4.73e+10
1.78E+01
1.54E+01
2.90E+00
3.94E+01
4.44E+00
3.68E+02
3.68E+02
1.06e+11
9.00E+01
4.67E+01
8.38E+01
3.42E+00
4.37E+01
1.20E+02
1.57E+02
M
D
Y
M
M
O
D
H
0
O
Y
Y
H
D
D
H
D
M
ICRP
Lung
Class'
O
D
0
D
D
Y
Y
Y
Y
Y
W
W
W
Y
Y
Y
W
W
Gl
Absorption
Factor (f,)a
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
3.00E-04
3.00E-04
3.00E-04
1.00E-04
1.00E-04
1.00E-04
8.00E-01
1.00E-02
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.05E-14
7.12E-12
3.68E-12
1.46E-13
8.65E-14
588E-13
3.32E-12
1.15E-12
3.45E-11
3.45E-11
2.51E-11
4.60E-13
4.02E-12
5.73E-12
2 95E-12
665E-12
6.53E-12
5.04E-13
Inhalation
(Risk/pCi)
1.17E-14
4.21E-12
2.26E-12
1.36E-13
6.92E-14
4.09E-13
4.59E-12
8.02E-13
1.15E-10
1.15E-10
6.93E-09
4.63E-12
2.18E-12
1.31E-11
201E-12
4.20E-12
4.92E-12
3.29E-13
External Exposure
(Risk/yr per pCi/g soil)
3.89E-06
3.71 E-07
O.OOE+0
2.68E-06
8.47E-06
4.52E-07
1.70E-06
2.88E-06
O.OOE+0
7.57E-07
O.OOE+0
2.92E-13
4.65E-08
789E-06
2.50E-07
1.31E-05
889E-07
3.45E-09
Jabte 4 continues on the following page: Refer to Endnotes on the last page.]
14
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors3
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Silver (47)

Sodium (11)

Strontium (38)

Isotope0
Ag-105
Ag-108
Ag-108m
Ag-108m+D
Ag-109m
Ag-110
Ag-110m
Ag-111
Na-22
Na-24
Sr-82
Sr-85
Sr-85m
Sr-89
Sr-90
Sr-90+D
Sr-91
Sr-92
CASRN"
014928-14-4
014391-65-2
014391-65-2m
014391-65-2m(+D)
014378-38-2(m)
014391-76-5
014391-76-5(m)
157690-04-0
013966-32-0
013982-04-2
014809-50-8
013967-73-2
013967-73-2(m)
014158-27-1
010098-97-2
010098-97-2(+D)
014331-91-0
014928-29-1
Radioactive
Half-life*
4.13E+01
2.37E+00
1.27E+02
1.27E+02
3.96E+01
2.46E+01
2.50E+02
7.46E+00
2.60E+00
1.50E+01
2.50E+01
6.48E+01
6.77E+01
5.06E+01
2.86E+01
2.86E+01
9.50E+00
2.71E-KX)
D
M
Y
Y
S
S
D
D
Y
H
D
D
M
D
Y
Y
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
D
D
D
D
D
D
D
D
D
D
Gl
Absorption
Factor (f,)fl
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
9.50E-01
9.50E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
Ingestion
(Risk/pCi)
1.63E-12
6 94E-15
605E-12
6 05E-12
271E-16
244E-15
843E-12
6 83E-12
802E-12
1 38E-12
2 58E-1 1
1.40E-12
1.80E-14
1.03E-11
409E-11
5.59E-11
2 82E-12
2 03E-12
Inhalation
(Risk/pCi)
2.33E-12
9.43E-15
7.02E-11
7.02E-11
3.46E-16
3.16E-15
3.21 E-11
5.24E-12
4.88E-12
7.51E-13
8.87E-12
1.14E-12
7.13E-15
3.68E-12
5.94E-11
6.93E-1 1
7.79E-13
4.70E-13
External Exposure
(Risk/yr per pCi/g soil)
—
5.78E-08
561E-06
5.62E-06
1.16E-09
1.13E-07
1 05E-05
8.51 E-08
8.18E-06
1 .77E-05
9.00E-11
1.54E-06
5.24E-07
5.38E-10
O.OOE+0
O.OOE+0
2.67E-06
5.20E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
15
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Element
(Atomic Number)
Sulfur (16)
Tantalum (73)
Technetium (43)

Tellurium (52)

Isotope6
S-35
Ta-182
Tc-95
Tc-95m
Tc-96
Tc-96m
Tc-97
Tc-97m
Tc-99
Tc-99m
Te-125m
Te-127
Te-127m
Te-129
Te-129m
Te-131
Te-131m
Te-132
CASRN"
015117-53-0
013982-00-8
014809-56-4
014809-56-4(m)
014808-44-7
014808-44-7(m)
015759-35-0
015759-35-0(m)
014133-76-7
014133-76-7(m)
014390-73-9(m)
013981-49-2
013981-49-2(m)
014269-71-7
014269-71-7(m)
014683-12-6
014683-12-6(m)
014234-28-7
Radioactive
Half-life*
8.74E+01
1.15E+02
2.00E+01
6.10E+01
4.28E+00
5.15E+01
2.60E+06
8.90E+01
2.13E+05
6.02E+00
5.80E+01
9.35E+00
1.09E+02
6.96E+01
3.36E+01
2.50E+01
3.00E+01
7.82E+01
D
D
H
D
D
M
Y
D
Y
H
D
H
D
M
D
M
H
H
ICRP
Lung
Class'
O
Y
W
W
W
W
W
W
W
W
W
W
W
W
W
W
W
W
61
Absorption
Factor (f,)fl
8.00E-01
1.00E-03
8.00E-01
8.00E-01
8 OOE-01
8.00E-01
8.00E-01
8.00E-01
8.00E-01
8.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
4 16E-13
703E-12
6.81E-14
1 24E-12
2.28E-12
261E-14
1.58E-13
1.20E-12
1 40E-12
5.58E-14
251E-12
8.55E-13
601E-12
1 48E-13
1.17E-11
3.90E-13
881E-12
1 22E-1 1
Inhalation
(Risk/pCi)
1.85E-13
1.65E-11
3.38E-14
2.10E-12
1.94E-12
2.26E-14
3.44E-13
1.96E-12
2.89E-12
3.49E-14
2.85E-12
4.32E-13
1.31E-11
1.46E-13
1.33E-11
2.48E-13
8.40E-12
8.38E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
466E-06
2 72E-06
2.08E-06
9.36E-06
7 72E-08
2.49E-10
2.67E-10
6.19E-13
2.51 E-07
2.16E-09
1.62E-08
7.10E-10
1.46E-07
6.92E-08
1.35E-06
5.31 E-06
4.31E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
16
-------
Table 4: Radionuclide Carcinogenicity -- Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Terbium (65)

Thallium (81)

Thorium (90)

Thulium (69)

Tin (50)
Isotope'
Tb-158
Tb-160
TI-202
TI-204
TI-208
TI-209
Th-227
Th-228
Th-228+D
Th-229
Th-229+D
Th-230
Th-231
Th-232
Th-234
Tm-170
Tm-171
Sn-113
CASRN"
015759-55-4
013981-29-8
015720-57-7
013968-51-9
014913-50-9
015690-73-0
015623-47-9
014274-82-9
014274-82-9(+D)
015594-54-4
015594-54-4(+D)
014269-63-7
014932-40-2
007440-29-1
015065-10-8
013981-30-1
014333-45-0
013966-06-8
Radioactive
Half-life*
1.50E+02
7.23E+01
1.22E+01
3.78E+00
3.05E+00
2.20E+00
1.87E+01
1.91E+00
1.91E+00
7.34E+03
7.34E+03
7.70E+04
2.55E+01
1.41E+10
2.41 E+01
1.29E+02
1.92E+00
1.15E+02
Y
D
D
Y
M
M
D
Y
Y
Y
Y
Y
H
Y
D
D
Y
D
ICRP
Lung
Class'
W
W
O
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)B
3.00E-04
3.00E-04
9.50E-01
9.50E-01
9.50E-01
9.50E-01
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
300E-04
3.00E-04
2.00E-02
Ingestion
(Risk/pCi)
420E-12
7.62E-12
1.01E-12
1 97E-12
1.75E-14
1 40E-14
4 04E-1 1
629E-11
2.31E-10
5.65E-11
3.56E-10
375E-11
1.79E-12
328E-11
1 93E-1 1
7 50E-12
586E-13
3.72E-12
Inhalation
(Risk/pCi)
7.04E-1 1
1.14E-11
6.07E-13
1.15E-12
1.36E-14
1.12E-14
4.31 E-09
9.45E-08
9.68E-08
7.60E-08
8.26E-08
1.72E-08
1.10E-12
1.93E-08
1.90E-11
1.10E-11
1.84E-12
6.61 E-1 2
External Exposure
(Risk/yr per pCi/g soil)
—
4.03E-06
1 .42E-06
8 72E-10
1.45E-05
7.83E-06
1.74E-07
5.28E-10
9.94E-07
5.94E-08
5.99E-07
4.40E-11
2.09E-09
1.97E-11
350E-09
3.84E-09
3.15E-10
2.96E-09
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
17
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Table 4: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)

Tungsten (74)

Uranium (92)

Vanadium (23)
Isotope0
Sn-121
Sn-121m
Sn-125
Sn-126
W-181
W-185
W-187
U-232
U-233
U-234
U-235
U-235+D
U-236
U-237
U-238
U-238+D
U-240
V-48
CASRN"
014683-06-8
014683-06-8(m)
014683-08-0
015832-50-5
015749-46-9
014932-41-3
014983-48-3
014158-29-3
013968-55-3
013966-29-5
015117-96-1
01 511 7-96-1 (+D)
013982-70-2
014269-75-1
007440-61-1
007440-61 -1(+D)
015687-53-3
014331-97-6
Radioactive
Half-life*
2.71E-KM
5.55E+01
9.64E+00
1.00E+05
1.21E+02
7.51 E+01
2.38E+01
7.20E+01
1.59E+05
2.45E+05
7.04E+08
7.04E+08
2.34E+07
6.75E+00
4.47E+09
4.47E+09
1.41E+01
1.60E+01
H
Y
O
Y
0
D
H
Y
Y
Y
Y
Y
Y
O
Y
Y
H
0
ICRP
Lung
Class'
W
W
W
W
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
Gl
Absorption
Factor (f,)"
200E-02
2.00E-02
2.00E-02
2.00E-02
3.00E-O1
300E-01
3.00E-01
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
500E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
1.00E-02
Ingestion
(Risk/pCi)
122E-12
200E-12
1.68E-11
2.12E-11
2.72E-13
2.04E-12
246E-12
8.12E-11
4.48E-11
444E-11
452E-11
4.70E-11
421E-11
398E-12
427E-11
6.20E-11
547E-12
756E-12
Inhalation
(Risk/pCi)
613E-13
7.46E-12
1.19E-11
4.26E-11
8.02E-14
4.26E-13
529E-13
5.29E-08
1.41E-08
140E-08
1.30E-08
1.30E-08
1.32E-08
3.12E-12
1.24E-08
124E-08
3.35E-12
6.84E-12
External Exposure
(Risk/yr per pCi/g soil)

—
1.21E-06
332E-08
2.11E-08
5.03E-11
1.63E-06
3.42E-11
3.52E-11
2.14E-11
2.63E-07
2.65E-07
1.72E-11
1.37E-07
1.50E-11
525E-08
1.09E-10
1.12E-05
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
18
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Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Xenon (54)

Yttrium (39)

Zinc (30)
Isotope6
Xe-122
Xe-123
Xe-125
Xe-127
Xe-129m
Xe-131m
Xe-133
Xe-133m
Xe-135
Xe-135m
Xe-137
Xe-138
Y-90
Y-91
Y-91m
Y-92
Y-93
Zn-65
CASRN"
015151-09-4
015700-10-4
013994-18-8
013994-19-9
013965-99-6(m)
01 4683-1 1-5(m)
014932-42-4
014932-42-4(m)
014995-62-1
014995-62-1 (m)
014835-21-3
015751-81-2
010098-91-6
014234-24-3
014234-24-3(m)
015751-59-4
014981-70-5
013982-39-3
ICRP Gl
Radioactive Lung Absorption Ingestion
Half-life" Class' Factor (f,)fl (Risk/pCi)
2.01 E+01
2.14E+00
1.68E+01
3.64E+01
8.89E+00
1.18E+01
5.25E+00
2.19E+00
9.11E+00
1.54E+01
3.83E+00
1.41E+01
6.41 E+01
5.85E+01
4.97E+01
3.54E+00
1.01E+01
2.44E+02
H -
U • „. —
LJ *
D —
D — -
D —
D —
D —
LJ *
M -
M —
M — —
H Y 1.00E-04 1.50E-11
D Y 1.00E-04 1.35E-11
M Y 1.00E-04 3.69E-14
H Y 1.00E-04 1 95E-12
H Y 1.00E-04 574E-12
D Y 5.00E-01 993E-12
Inhalation
(Risk/pCi)
3.08E-15
8.92E-16
1.20E-15
4.09E-16
5.74E-16
4.13E-16
4.14E-16
5.12E-16
7.45E-16
1.88E-16
1.39E-15
2.06E-15
9.90E-12
1.85E-11
2.99E-14
1.61E-12
3.48E-12
9.98E-12
External Exposure
(Risk/yr per pCI/g soil)
—
—
—
—
—
—
—
—
—
—
—
—
O.OOE+0
1.41E-08
1 90E-06
9.80E-07
3.41E-07
2.27E-06
[Table 4 continues on the fottowing page: Refer to Endnotes on the last page.]
19
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Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
MAY 1995

Element
(Atomic Number)

Zirconium (40)

lsotopec
Zn-69
Zn-69m
Zr-93
Zr-95
Zr-97

CASRN"
013982-23-5
013982-23-5(m)
015751-77-6
013967-71-0
014928-30-4

Radioactive
Half-life*
5.56E+01
1.38E+01
1.53E+06
6.40E+01
1.69E-«-01

M
H
Y
D
H

ICRP
Lung
Class'
Y
Y
W
W
W
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Gl
Absorption
Factor (f,)8
5.00E-01
5.00E-01
2.00E-03
2.00E-03
2.00E-03

Ingestion
(Risk/pCi)
6.19E-14
1.52E-12
521E-13
3.92E-12
1.04E-11

Inhalation
(Risk/pCi)
1.04E-13
1.17E-12
5.26E-12
6.48E-12
4.73E-12

External Exposure
(Risk/yr per pCi/g soil)
2.03E-1 1
1.43E-06
O.OOE+0
2.81 E-06
6.85E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
20
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Table 4: Radionuclide Carcinogenicity -- Slope Factors3 MAY 1995
(In Units of Picocuriesb)
ENDNOTES:
EPA classifies all radionuclides as Group A (known human) carcinogens. Radionuclide slope factors are calculated by EPA's Office of Radiation and Indoor Air (ORIA)
to assist HEAST users with risk-related evaluations and decision-making at various stages of the remediation process. Ingestion and inhalation slope factors are central
estimates in a linear model of the age-averaged, lifetime attributable radiation cancer incidence (fatal and nonfatal cancer) risk per unit of activity inhaled or ingested, expressed
as risk/picocurie (pCi). External exposure slope factors are central estimates of the lifetime attributable radiation cancer incidence risk for each year of exposure to external
radiation from photon-emitting radionuclides distributed uniformly in a thick layer of soil, and are expressed as risk/yr per pCi/gram of soil. If required, slope factors in Table
4 can be converted into the International System (SI) units of becquerels (1 Bq = 1 nuclear transformation per second) by dividing each inhalation, ingestion, or external
exposure value by 27.03. Users can calculate cancer risks using slope factors expressed in either customary units or SI units with equivalent results, provided that they also
use air, water and soil concentration values in the same system of units. For a discussion on the derivation of radionuclide slope factors and guidance on their use, refer to
the User's Guide section on radionuclide carcinogenicity.

A curie (Ci), the customary unit of activity, is equal to 3.7 x 1010 nuclear transformations per second. 1 picocurie (pCi) = 1012 Ci.

For each radionuclide listed, slope factors correspond to the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that
the risks from associated short-lived radioactive decay products (i.e., those decay products with radioactive half-lives less than or equal to 6 months) are also included. Refer
to Exhibit 1 in the User's Guide section on radionuclide carcinogenicity for guidance on determining slope factors for partial or complete radioactive decay chains.

Chemical Abstract Service Reference Number (CASRN). For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each
chain member.

Radioactive half-life: S - Second, M = Minute, D = Day, Y = Year. For those radionuclides with decay products (+D), half-lives are listed for the parent radionuclide.

Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.

g Gastrointestinal (Gl) absorption factors are the fractional amounts of each radionuclide absorbed across the Gl tract into the bloodstream. Lung clearance classifications
and Gl absorption factors are provided for reference only. DggQt use these factors to adjust inhalation or ingestion slope factors. See the User's Guide for instructions.
21
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APPENDIX A: TECHNICAL INFORMATION

I. DATA SOURCES AND SELECTION CRITERIA USED IN HEAST

II. DOSE CONVERSIONS ON HEAST

III. CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY
NUMBER CROSS REFERENCE

IV. EFFECT LEVEL DEFINITIONS

V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
-------
APPENDIX A-l

I. DATA SOURCES AND SELECTION CRITERIA USED IN HEAST

A. Description of Sources and Documents Cited in HEAST

1. The Integrated Risk Information System (IRIS)

IRIS is an on-line data base developed by the EPA for compilation of risk
assessment and regulatory information on chemicals and physical agents. IRIS is the
primary communications mechanism for distribution of health hazard assessment
information derived by the various intra-Agency Work Groups. The primary intent of
IRIS is to provide guidance to EPA personnel in making risk management decisions.
An IRIS chemical file contains a Work Group verified summary of the available
information on hazard and dose-response assessment for noncarcinogenic and/or
carcinogenic effects for that chemical and is not an extensive toxicologic data base.
Risk assessment values placed on IRIS are considered Agency consensus and take
precedence over differing risk assessment values from other EPA sources. Each file
includes referenced citations and EPA contacts for obtaining further information on any
specific chemical or agent. The IRIS data base was made available to State and local
governments, as well as to the public, in April 1988.

* Questions concerning IRIS: Call RISK INFORMATION HOTLINE at (513) 569-7254

2. EPA Work Groups:

Risk assessment values for chemicals currently being considered by EPA Work
Groups, but not yet on IRIS, are included in HEAST. The EPA Reference
Dose/Reference Concentration (RfD/RfC) Work Group and the Carcinogen Risk
Assessment Verification Endeavor (CRAVE) Work Group validates Agency systemic
toxicity and carcinogen risk assessments, respectively. These Work Groups are also
responsible for resolving any conflicts regarding toxicity values developed by various
Program Offices. Work Group members represent many different EPA offices and are
scientists experienced in issues related to both the qualitative and quantitative risk
assessment of carcinogenic and toxic agents. Values verified by these Work Groups
have undergone extensive peer review and represent an Agency consensus. Verified
risk assessment values are entered into the IRIS data base monthly.

* Questions concerning RfD/RfC Work Group: Call Annie Jarabek NCEA-Research
Triangle Park (RTP) at (919) 541-4847
A-1
-------
* Questions concerning CRAVE Work Group: Call Jim Cogliano at (202) 260-3814
NCEA-Washington, DC
3. Office of Research and Development (ORD/National Center for
Environmental Assessment (NCEA) OSWER-OAQPS (Office of Solid Waste and
Emergency Response-Office of Air Quality Planning and Standards) Documents:

A listing of most ORD/NCEA OSWER-OAQPS documents can be found in the
Chemical Assessments and Related Activities (CARA) list (available through NTIS) or in
the CERI (Center for Environmental Research Information) Office of Research and
Development publications list. The CARA is produced by the National Center for
Environmental Assessment (NCEA). All OSWER-OAQPS documents are subject to a
minimum of internal EPA peer review or a maximum of EPA/Peer Review
Workshop/Science Advisory Board and public comments prior to finalization.

* Information on the availability of OSWER-OAQPS documents can be obtained from
the following sources:

All Documents:

Technical Information Staff
National Center for Environmental Assessment (RD-689)
U.S. Environmental Protection Agency
401 M Street, S.W.
Washington, D.C. 20460
(202) 260-7345

Published Documents:

Technology Transfer and Support Division, National Risk Management
Research Laboratoryt
Office of Research and Development
U.S. Environmental Protection Agency
26 W. Martin Luther King Drive
Cincinnati, OH 45268
(513)569-7562
fFormerly, Center for Environmental Research Information (CERI)

Documents Available Through RCRA/Superfund:

Hotline Number 1-800-424-9346
A-2
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Documents Available from NTIS:

National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
(703) 487-4650

Health Effects Assessments (HEAs): This document series was prepared by the
National Center for Environmental Assessment (NCEA-CIN) for the Office of
Emergency and Remedial Response (Superfund). HEAs are intended for use by the
OERR in evaluating risk for its preliminary assessment process at uncontrolled sites,
and for appraising clean-up alternatives in its remedial investigation/feasibility studies.
HEAs are brief, quantitatively oriented, preliminary assessment of relevant health
effects data. HEAs are subject to internal EPA review by staff within the Office of Health
and Environmental Assessment. Final drafts of HEAs become part of the RCRA and
Superfund dockets and are available through NTIS. This series has recently been
incorporated into the following HEED series.

Health and Environmental Effects Documents (HEEDs): This document series is
prepared by the National Center for Environmental Assessment (NCEA-CIN) for the
Office of Solid Waste and Emergency Response (OSWER). HEEDs are intended to
support listings under the Resource Conservation and Recovery Act (RCRA) as well as
to provide health-related limits and goals for emergency and remedial actions under the
Comprehensive Environmental Response, Compensation and Liability Act (CERCLA).
Within a HEED, both published literature and information within Agency Program
Offices are evaluated as they pertain to potential human health, aquatic life and
environmental effects of hazardous waste constituents. Quantitative estimates,
including reference doses for chronic and subchronic duration for both inhalation and
oral exposures, carcinogenic potency factors, unit risk estimates for air and drinking
water, and reportable quantities (RQs) based on chronic toxicity and carcinogenicity are
determined when sufficient data are available. HEEDs are subject to internal EPA
review by staff within the Office of Health and Environmental Assessment and the
Office of Pesticides and Toxic Substances. Final drafts of HEEDs become part of the
RCRA and Superfund public dockets and are available through NTIS.

Health and Environmental Effects Profiles (HEEPs): This document series was
prepared by the National Center for Environmental Assessment (NCEA-CIN) for the
Office of Solid Waste and Emergency Response (OSWER). HEEPs have been
superseded by HEEDs since mid-FY87. HEEPs are intended to support listings of
hazardous constituents of a wide range of waste streams under Section 3001 of the
Resource Conservation and Recovery Act (RCRA), as well as to provide health-related
limits for emergency actions under Section 010 of the Comprehensive Environmental
Response, Compensation and Liability Act (CERCLA). HEEPs are summaries of the

A-3
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literature concerning health hazards associated with environmental exposures to
chemicals or compounds and are very similar to HEEDs as described above. HEEPs
were subject to internal EPA review by staff within the Office of Health and
Environmental Assessment. HEEPS are part of the RCRA and CERCLA public
dockets. Final drafts are available through NTIS.

Air Quality Criteria Documents (AQCDs): This document series is prepared by the
National Center for Environmental Assessment (NCEA-RTP) for the Office of Air and
Radiation (OAR). AQCDs are intended to support National Ambient Air Quality
Standards (NAAQS) set under Sections 108-110 of the Clean Air Act. These
documents are evaluations of the available scientific literature on the potential health
effects of air pollutants. AQCDs are subject to internal EPA review by staff within the
Office of Health and Environmental Assessment and the Office of Air and Radiation.
Further review is conducted by the Science Advisory Board/Clean Air Scientific
Advisory Committee, and then, these documents are subject to peer review workshops
and public comments. The AQCDs are mandated by the Clean Air Act and are revised
at 5-year intervals. AQCDs become part of the OAR public docket and final drafts are
available through NTIS.

Health Assessment Documents (HADs): This document series is prepared by the
National Center for Environmental Assessment (NCEA-RTP and NCEA-CIN) for the
Office of Air and Radiation (OAR). HADs are intended for use by the Office of Air
Quality Planning and Standards (OAQPS) to determine possible listing of hazardous air
pollutants (HAP) under sections 111 and 112 of the Clean Air Act. These documents
are evaluations of the available scientific literature on the potential health effects of air
pollutants and serve as the scientific data base for establishing relationships between
exposure concentrations and potential health risks. HADs are subject to internal EPA
review by staff within the Office of Health and Environmental Assessment and the
Office of Air and Radiation. Further review is conducted by the Science Advisory
Board/Clean Air Scientific Advisory Committee, and then, these documents are subject
to peer review workshops and public comments. HADs become part of the OAR public
docket and final drafts are available through NTIS.

4. Miscellaneous Documents:

Drinking Water Criteria Documents (DWCDs): The National Center for Environmental
Assessment (NCEA-CIN) prepares a portion of this document series for the Office of
Water (OW). DWCDs are intended to assist the OW in deriving criteria standards for
chemicals in drinking water, as required under Section 412(b)(3)(A) of the Safe Drinking
Water Act, as amended in 1986. The DWCDs are comprehensive evaluations of
potential health effects, including mechanisms of toxicity, with specific emphasis on
data providing dose-response information. DWCDs contain Health Advisories (Has) for
1-day, 10-day and longer-term exposures and drinking water equivalent levels for

A-4
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lifetime exposures. DWCDs are subject to internal EPA review by staff within the Office
of Health and Environmental Assessment and the Office of Water. Selected documents
are reviewed by the Science Advisory Board and are subject to peer review workshops
and public comments. DWCDs become part of the Safe Drinking Water (SOW) public
docket and final drafts are available through NTIS.
B. Selection Criteria and Sources of HEAST Values

Chemicals with derived noncarcinogenic and/or carcinogen risk assessment values
that have had some level of peer review (i.e., those in peer reviewed EPA documents
or under review by EPA Work Groups) are included in HEAST; this does not include
many interim values (values not found in final EPA documents or not being considered
by Work Groups) derived for various purposes within Superfund and other Program
Offices. In updating the HEAST, the first source that is checked is the Integrated Risk
Information System (IRIS) for revised or newly added risk assessment values.
Secondly, the status of chemicals under discussion by the RfD/RfC and CRAVE Work
Groups is reviewed. The National Center for Environmental Assessment's Chemical
Assessments and Related Activities (CARA) list is also reviewed for new Office of
Water, Office of Air Quality Planning and Standards, and Office of Solid Waste and
Emergency Response risk assessment documents (HEEDs, HEEPs, HEAs, HADs,
AQCDs, DWCDs).

The HEAST also contains chemicals commonly found at RCRA (Resource
Conservation and Recovery Act) sites as identified by the Office of Solid Waste's
Technical Assessment Branch. Questions about RCRA chemicals may be addressed
by calling the Health Assessment Section (Office of Solid Waste) at (202) 260-4761.
Finally, the Office of Radiation Programs provides data on radionuclides for Table 4A
and 4B of the HEAST. Radionuclides included are those thought to be most commonly
encountered at Superfund sites. Questions concerning radionuclides carcinogenicity
should first be addressed by contacting the appropriate Regional Radiation Program
Manager. A listing of these managers and several contacts in the Office of Radiation
Programs can be found in Exhibit 2 of the User's Guide -Radionuclide Carcinogenicity.
A-5
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APPENDIX A-ll

II. DOSE CONVERSIONS ON HEAST

In January 1991, the decision was made to replace inhalation Reference Doses
(RfDi) for noncancer toxicity and inhalation slope factors for carcinogenicity, previously
available on the IRIS data base, with Reference Concentrations (RFC) and inhalation
unit risks, respectively. RfCs and unit risks are expressed in terms of concentration in
air (mg/m3), not in terms of "dose" (mg/kg-day) like the RfDs and the oral and inhalation
slope factors. This presents a problem for the Superfund program, since the current
Hazard Ranking System (MRS) and the Risk Assessment Guidance for superfund
(RAGS): Human Health Evaluation manual, Parts A and B were developed using
chronic daily intakes and health criteria expressed in units of mg/kg-day.

The decision to replace inhalation slope factors and RfDi values expressed in
mg/kg-day with unit risk and RfC values expressed in mg/m3 was based on two major
factors: 1) the workgroups felt that it was technically more accurate to base toxicity
values directly on measured air concentrations instead of making the metabolic
pharmacokinetic and/or surface area adjustments required to estimate an "internal
dose"; and 2) there are compounds that elicit route-of-entry effects (e.g., sensitizers
and irritants) where the toxic effect is to the respiratory system or exchange boundary
where a measure of "internal dose" might inappropriately imply effects to other organ
systems or effects from other exposure routes.

Superfund recognizes the importance of these issues and is actively working
with EPA's Office of Research and Development to evaluate the impact of these
changes on its program regulations and guidance. In the short term, however,
modification of program regulations and guidance is not a viable option. Therefore, the
chairs of the RfD/RfC and CRAVE Work Groups were consulted regarding Superfund's
need to make the conversion from a concentration in air to dose. There was agreement
that, in many cases, converting the air concentration data to a dose (in mg/kg-day) may
not add significant uncertainty to the Superfund risk assessment process, and therefore
may be a reasonable use of the data given appropriate circumstances and Superfund
program objectives. These Work Groups will continue to work with the Superfund
program to identify specific instances where it is not appropriate to make the conversion
from unit risk/RfC to inhalation slope factor/RfD due to the large uncertainty introduced
by the assumptions used in the conversion.

Generally, the Superfund Health Risk Technical Support Center will be
responsible for making all appropriate conversions and the values will be identified with
appropriate highlights or footnotes in the Health Effects Assessment Summary Tables
(HEAST). Therefore, HEAST users are strongly advised against making such
conversions themselves. However, it is a critical responsibility of the risk assessor to

A-7
-------
consult the original reports cited in the HEAST and to appropriately characterize or
caveat the resulting risk estimates derived from these values so that managers are fully
informed of their origin and related uncertainties.
A-8
-------
APPENDIX A-lll

III. CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE
REGISTRY NUMBER CROSS REFERENCE

This section lists chemicals and their respective Chemical Abstracts Service
Registry Number (CASRN) for cross referencing on the HEAST. Chemicals may be
searched either alphabetically by chemical name or numerically by the CASRN.
A-9
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME)
Nay 1995
ACENAPHTHENE 000083-32-9
ACENAPTHYLENE 000208-96-8
ACEPHATE 030560-19-1
ACETONE 000067-64-1
ACETONE CYANOHYDRIH 000075-86-5
ACETONITR1LE 000075-05-8
ACETOPHEMONE 000098-86-2
ACROLEIN 000107-02-8
ACRYLAMIDE 000079-06-1
ACRYLIC ACID 000079-10-7
ACRYLOMITRILE 000107-13-1
ADIPOMITRILE 000111-69-3
ALACHLOR 015972-60-8
ALDICARB 000116-06-3
ALDRIN 000309-00-2
ACLIDOCHLOR 000093-71-0
ALLYL ALCOHOL 000107-18-6
ALLYL CHLORIDE 000107-05-1
ALUMINUM 007429-90-5
ALUMINUM PHOSPHIDE 020859-73-8
AMETRYN 000834-12-8
AMINO-2-NAPHTHOL. 1- 002834-92-6
AMINO-2-NAPHTOL HYDROCHLORIDE. 1- 001198-27-2
AMINOPHENOL, M- 000591-27-5
AMINOPHENOL, 0- • 000095-55-6
AMINOPHENOL, P- 000123-30-8
AMINOPYRIDINE. 4- 000504-24-5
AMMONIA 007664-41-7
ANILINE 000062-53-3
ANTHRACENE 000120-12-7
ANTIMONY. METALLIC 007440-36-0
ANTIMONY PENTOXIDE 001314-60-9
ANTIMONY POTASSIUM TARTRATE 000304-61-0
ANTIMONY TETROXIDE 001332-81-6
ANTIMONY TR10XIDE 001309-64-4
ARAMITE 000140-57-8
AROCLOR 1248 012672-29-6
AROCLOR 1254 011097-69-1
ARSENIC. INORGANIC 007440-38-2
ASBESTOS 001332-21-4
ATRAZINE 001912-24-9
AZOBENZENE 000103-33-3
BARIUM 007440-39-3
BARIUM CYANIDE 000542-62-1
BENEFIN 001861-40-1
BENZAL CHLORIDE 000098-87-3
BENZALDEHYDE 000100-52-7
BENZALDEHYDE CYANOHYDRIN 000532-28-5
BENZENE 000071-43-2
BENZENETHIOL / (THIOPHENOL) 000108-98-5
BENZIDINE 000092-87-5
BENZOIC ACID 000065-85-0
BENZOTRICHLORIDE 000098-07-7
BENZOtA] ANTHRACENE 000056-55-3
BENZOCA1PYRENE 000050-32-8
BENZOW1FLUORANTHENE 000205-99-2
BENZOK1FLUORANTHENE 000207-08-9
BENZYL ALCOHOL 000100-51-6
BENZYL CHLORIDE 000100-44-7
BERYLLIUM 007440-41-7
BIPHENYL. 1.V 000092-52-4
BIS(2-CHLOROETHYL) ETHER 000111-44-4
BIS(2-CHLOROISOPROPYL) ETHER 039638-32-9
BIS(2-CHLORO-1-METHYLETHYL) ETHER 000108-06-1
BIS(2-ETHYLHEXYL) PHTHALATE
BIS(CHLOROMETHYL) ETHER
BISPHENOL A
BORON, ELEMENTAL
BORON TRIFLUORIDE
BROMIMATED DIBENZO-P-DIOXINS
BROMINATED DIBENZOFURANS
BROMOACETONE
BROMOCHLOROETHANES
BROMODICHLOROMETHANE
BROMOETHENE / (VINYL BROMIDE)
BROMOFORM
BROMOHETHANE
BROMOPHENYL PHENYL ETHER, 4-
BROMOPHOS
BROMOXYNIL
BROMOXYNIL OCTANOATE
BUSAN 77
BUSAN 90
BUTADIENE, 1.3-
BUTANOL. 1-
BUTYL BENZYL PHTHALATE. N-
BUTYLATE
BUTYLCHLORIDE, T-
BUTYROLACTONE. GAMMA-
CACODYLIC ACID
CADMIUM
CALCIUM CYANIDE
CAPROLACTAM
CAPTAFOL
CAPTAN
CARBARYL
(DEHP)000117-81-7
000542-88-1
000080-05-7
007440-42-8
007637-07-2
NO CASRN
NO CASRN
000598-31-2
NO CASRN
000075-27-4
000593-60-2
000075-25-2
000074-83-9
000101-55-3
002104-96-3
001689-84-5
001689-99-2
031512-74-0
002491-38-5
000106-99-0
000071-36-3
000085-68-7
002008-41-5
000507-20-0
000096-48-0
000075-60-5
007440-43-9
000592-01-8
000105-60-2
002425-06-1
000133-06-2
000063-25-2
CARBAZOLE
CARBOFURAN
CARBON DISULFIDE
CARBON MONOXIDE
CARBON TETRACHLORIDE
CHLORAL
CHLORANIL
CHLORDANE
CHLORINE CYANIDE
CHLORO-1.3-BUTADIENE.
000086-
001563-
000075-
000630-
000056-
000075
000118
000057
000506
2- / (CHLOROPRENE)
000126
CHLORO-2-METHYLANILINE, 4- 000095
CHLORO-2-METHYLANILINE HYDROCHLORIDE, 4-
003165
CHLORO-M-CRESOL, P-
CHLOROACETALDEHYDE
CHLOROACETIC ACID
CHLOROANILINE, 2-
CHLOROANILINE, 3-
CHLOROANILINE, 4-
CHLOROBENZENE
CHLOROBENZILATE
CHLOROBENZOIC ACID, P-
CHLOROBENZOTRIFLUORIDE, 4-
CHLOROBUTANE, 1-
CHLOROBUTANE, 2-
CHLOROCYCLOPENTADIENE
CHLOROFORM
CHLOROMETHANE / (METHYL CHLORIDE)
CHLOROHETHYL METHYL ETHER
CHLORONITROBENZENE, M-
0-
P-
74-8
66-2
15-0
05-0
23-5
87-6
75-2
•74-9
•77-4

-99-8
-69-2
CHLORONITROBENZENE,
CHLORONITROBENZENE,
CHLOROPHENOL, 2-
CHLOROPHENOL, 3-
CHLOROPHENOL, 4-
CHLOROPRENE
CHLOROPROPANE, 2-
CHLOROTHALONIL
CHLOROTOLUENE, M-
CHLOROTOLUENE, 0-
CHLOROTOLUENE, P-
CHLORPYRIFOS
CHLORPYRIFOS METHYL
CHLORTHIOPHOS
CHROMIUM(111)
CHROMIUM(VI)
CHRYSENE
000059
000107
000079
000095
000108
000106
000108
000510-
000074-
000098-
000109-
000078-
041851-
000067-
000074-
000107-
000121
000088
000100
000095
000108
000106
000126
000075
001897
000108
000095
000106
002921
005598
060238
016065
018540
000218
93-3
50-7
20-0
11-8
51-2
42-9
47-8
90-7
•15-6
•11-3
•56-6
•69-3
•86-4
-50-7
-66-3
-87-3
-30-2
-73-3
-73-3
-00-5
-57-8
43-0
48-9
99-8
29-6
45-6
•41-8
•49-8
•43-4
•88-2
•13-0
-56-4
-83-1
-29-9
-01-9
NAME/CASRN-1
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME) continued
Nay 1995
COKE OVEN EMISSIONS
COPPER
COPPER CYANIDE
CREOSOTE. COAL TAR
CRESOL, N- / (3-NETHYLPHENOL)
CRESOL, 0- / (2-HETHYLPHENOU
CRESOL, P- / (4-METHYLPHENOL)
CROTONALDEHYDE
CUMENE
CYANAZINE
CYANIDE
CYANOGEN
CYANOGEN BROMIDE
CYCLOATE
CYCLOHEXANOL
CYCLOHEXYLAMINE
CYCLONITE
CYCLOPENTADIENE
DACTHAL
DALAPON
2,4-DB
DDD
DDE
DDT
DECABROMODIPHENYL ETHER
DEHP
DI-N-OCTYL PHTHALATE
DIALLATE
DIAZINON
DIBENZOFURAN
DIBENZO[A,H]ANTHRACENE
DIBROMO-3-CHLOROPROPANE, 1.2
DIBROMOBENZENE, 1,4-
DIBROMOCHLOROMETHANE
DIBROMOETHANE, 1.2-
DIBUTYL PHTHALATE
DICAMBA
DICHLORO-2-BUTENE. 1.4-
DICHLOROBENZENE, 1.2-
DICHLOROBEN2ENE, 1,3-
DICHLOROBENZENE, 1.4-
DICHLOROBENZIDINE, 3.3'-
DICHLOROBUTENES
DICHLORODIFLUOROMETHANE
DICHLOROETHANE, 1,1-
DICHLOROETHMIE. 1.2-
DICHLOROETHYLENE. 1,1-
DICHLOROETHYLENE, 1.2- (NIXED
008007-45-2
007440-50-8
000544-92-3
008001-58-9
000108-39-4
000095-48-7
000106-44-5
000123-73-9
000098-82-8
021725-46-2
000057-12-5
000460-19-5
000506-68-3
001134-23-2
000108-93-0
000108-91-8
000121-82-4
000542-92-7
001861-32-1
000075-99-0
000094-82-6
000072-54-8
000072-55-9
000050-29-3
001163-19-5
000117-81-7
000117-84-0
002303-16-4
000333-41-5
000132-64-9
000053-70-3
000096-12-8
000106-37-6
000124-48-1
000106-93-4
000084-74-2
001918-00-9
000764-41-0
000095-50-1
000541-73-1
000106-46-7
000091-94-1
NOCASRN
000075-71-8
000075-34-3
000107-06-2
000075-35-4
ISONERS)
DICHLOROETHYLENE, 1,2-C-
DICHLOROETHYLENE. 1,2-T-
DICHLOROMETHANE
DICHLOROPHENOL, 2,3-
DICHLOROPHENOL, 2,4-
DICHLOROPHENOL, 2,5-
DICHLOROPHENOL, 2,6-
DICHLOROPHENOL. 3,4-
DICHLOROPHENOL, 3.5-
DICHLOROPHENOXY ACETIC ACID, 2.4-
DICHLOROPHENOXY) BUTYRIC ACID, 4-(2
(2.4-DB)
DICHLOROPROPANE, 1,1-
DICHLOROPROPANE, 1,2-
DICHLOROPROPANE, 1.3-
DICHLOROPROPANE, 2.2-
DICHLOROPROPENE, 1,3- / (TELONE II)
DICHLORPROP
DICYCLOPENTADIENE
DIELDRIN
DIETHYL-P-NITROPHENYL PHOSPHATE
DIETHYL PHTHALATE
DIETHYLAMI LINE, N.N-
DIETHYLENE GLYCOL MONOBUTYL ETHER
DIETHYLENE GLYCOL MONOETHYL ETHER
DIETHYLFORMAMIDE
DIETHYLHYDRAZINE, 1.2-
DIETHYLSTILBESTROL
DIMETHOATE
DIMETHOXYBENZIDINE, 3,3'-
DINETHYLANILINE, 2,4-
DIMETHYLANILINE HYDROCHLORIDE, 2.4-
DINETHYLANILINE, N.N-
DIMETHYLBENZIDINE. 3,3'-
DIMETHYLBENZ[A]ANTHRACENE, 7.12-
DINETHYLFORMAMIDE, N,N-
DIMETHYLHYDRAZINE, 1,1-
DIMETHYLHYDRAZINE. 1,2-
DIMETHYLPHENOL. 2,3-
DIMETHYLPHENOL, 2,4-
DIMETHYLPHENOL, 2,5-
DIMETHYLPHENOL, 2,6-
DIMETHYLPHENOL. 3,4-
DIMETHYLPHTHALATE
DIMETHYLSULFATE
DIMETHYLTEREPHTHALATE
DIMETHYLUREA, N.N-
000540-59-0 DINITRO-0-CRESOL, 4,6-
000156-59-2 DINITRO-P-CRESOL, 2,6-
000156-60-5 DINITROBENZENE. 1.2-
000075-09-2 DINITROBENZENE. 1.3-
000576-24-9 DINITROBENZENE, 1,4-
000120-83-2 DINITROPHENOL, 2,3-
000583-78-8 DINITROPHENOL, 2,4-
000087-65-0 DINITROPHENOL, 2,5-
000095-77-2 DINITROPHENOL, 2,6-
000591-35-5 DINITROPHENOL, 3,5-
000094-75-7 DINITROTOLUENE, 2,3-
,4- / DINITROTOLUENE, 2,4
000094-82-6 DINITROTOLUENE, 2,5-
000078-99-9 DINITROTOLUENE, 2,6-
000078-87-5 DINITROTOLUENE. 3,4-
000142-28-9 DINOSEB
000594-20-7 DIOXANE, 1,4-
000542-75-6 DIPHENYLAMINE, N,N-
000120-36-5 DIPHENYLHYDRAZINE, 1,2-
000077-73-6 DIPHENYLMETHANE DIISOCYANATE
000060-57-1 DIRECT BLACK 38
000311-45-5 DIRECT BLUE 6
000084-66-2 DIRECT BROUN 95
000091-66-7 DIRECT LIGHTFAST BLUE
000112-34-5 DIRECT SKY BLUE 6B
000111-90-0 DISULFOTON
000617-84-5 ENDOSULFAN
001615-80-1 ENDOTHALL
000056-53-1 ENDRIN
000060-51-5 EPICHLOROHYDRIN
000119-90-4 EPTC
000095-68-1 ETHOPROP
021436-96-4 ETHOXYETHANOL, 2-
000121-69-7 ETHOXYETHANOL ACETATE, 2-
000119-93-7 ETHOXYETHANOL ACRYLATE. 2-
000057-97-6 ETHOXYETHANOL DODECANOATE, 2-
000068-12-2 ETHOXYETHANOL PHOSPHATE, 2-
000057-14-7 ETHOXYETHYL METHACRYLATE, 2-
000540-73-8 ETHYL ACETATE
000526-75-0 ETHYL ACRYLATE
000105-67-9 ETHYL BENZENE
000095-87-4 ETHYL CHLORIDE
000576-26-1 ETHYL ETHER
000095-65-8 ETHYL METHACRYLATE
000131-11-3 ETHYL-0-XYLENE, 4-
000077-78-1 ETHYLANILINE. N-
000120-61-6 ETHYLENE CYANOHYDRIN
000598-94-7 ETHYLENE DIAMINE
000534
000609
000528
000099-
000100
000066
000051
000329
000573
000586
000602
000121
000619
000606
000610
000088
000123-
000122-
000122-
000101
001937
002602
016071
004399-
002610
000298
000115-
000145-
000072
000106-
000759-
013194-
000110-
000111-
000106
000106
068554
002370
000141-
000140-
000100-
000075-
000060-
000097
000934-
000103-
000109-
000107-
52-1
93-8
29-0
65-0
25-4
56-8
28-5
71-5
56-8
11-8
01-7
14-2
15-8
20-2
39-9
85-7
91-1
39-4
66-7
68-8
37-7
46-2
86-6
55-7
05-1
04-4
29-7
73-3
20-8
89-8
94-4
48-4
80-5
15-9
74-1
13-8
00-7
63-0
78-6
88-5
41-4
00-3
29-7
63-2
80-5
69-5
78-4
15-3
NAME/CASRN-2
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME) Continued
May 1995
ETHYLENE GLYCOL 000107-21-1
ETHYLEHE GLYCOL NONOBUTYL ETHER 000111-76-2
ETHYLENE OXIDE 000075-21-8
ETHYLEME THIOUREA 000096-45-7
ETHYLTOLUENE. M- 000620-14-4
ETHYLTOLUENE, 0- 000611-14-3
ETHYLTOLUENE, P- 000622-96-8
FLUORANTHENE 000206-44-0
FLUORENE 000086-73-7
FLUORINE / (SOLUBLE FLUORIDE) 007782-41-4
FLURIDONE 059756-60-4
FOLPET 000133-07-3
FORMALDEHYDE 000050-00-0
FORMALDEHYDE CYANOHYDRIN 000107-16-4
FORMIC ACID 000064-18-6
FURAN 000110-00-9
FURAZOLIDONE 000067-45-8
FURFURAL 000098-01-1
FURIUM 000531-82-8
GLYCIDALDEHYDE 000765-34-4
HEPTACHLOR 000076-44-8
HEPTACHLOR EPOXIDE 001024-57-3
HEPTANE, N- 000142-82-5
HEXABROMOBENZENE 000087-82-1
HEXACHLOROBENZENE 000118-74-1
HEXACHLOROBUTADIENE 000087-68-3
HEXACHLOROCYCLOHEXANE, ALPHA- 000319-84-6
HEXACHLOROCYCLOHEXANE, BETA- 000319-85-7
HEXACHLOROCYCLOHEXANE. DELTA- 000319-86-8
HEXACHLOROCYCLOHEXANE, EPSILON- 006108-10-7
HEXACHLOROCYCLOHEXANE, GAMMA- 000058-89-9
HEXACHLOROCYCLOHEXANE-TECHNICAL 000608-73-1
HEXACHLOROCYCLOPENTADIENE 000077-47-4
HEXACHLOROETHANE 000067-72-1
HEXACHLOROPHENE 000070-30-4
HEXAMETHYLENE DIAMINE 000124-09-4
HEXANE, N- 000110-54-3
HEXANONE, 2- 000591-78-6
HYDRAZINE 000302-01-2
HYDRAZINE SULFATE 010034-93-2
HYDROGEN SULFIDE 007783-06-4
HYDROQUINONE 000123-31-9
INDENOI1,2,3-CD]PYRENE 000193-39-5
IRON 007439-89-6
ISOBUTYL ALCOHOL 000078-83-1
ISOPHORONE 000078-59-1
ISOPROPALIN 033820-53-0
LACTONITRILE 000078-97-7
LEAD 007439-92-1
LEAD ALKYLS NO CASRN
LINURON 000330-55-2
MALATHION 000121-75-5
MALEIC ANHYDRIDE 000108-31-6
MALEIC HYDRAZIDE 000123-33-1
MALONONITRILE 000109-77-3
MANCOZEB 008018-01-7
MANEB 012427-38-2
MANGANESE 007439-96-5
MEPHOSFOLAN 000950-10-7
MERCURIC CHLORIDE 007487-94-7
MERCURY, ELEMENTAL 007439-97-6
MERPHOS 000150-50-5
MERPHOS OXIDE 000078-48-8
METHACRYLONITRILE 000126-98-7
METHANOL 000067-56-1
METHOMYL 016752-77-5
METHOXY-5-NITROANILINE, 2- 000099-59-2
METHOXYCHLOR 000072-43-5
METHOXYETHANOL, 2- 000109-86-4
METHOXYETHANOL ACETATE, 2- 000110-49-6
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2-
000094-81-5
METHYL-4-CHLOROPHENOXY) PROPIONIC ACID, 2-(2-
000093-65-2
METHYL-4-CHLOROPHENOXY ACETIC ACID, 2-
000094-74-6
METHYL-5-NITROANILINE, 2- 000099-55-8
METHYL ACETATE 000079-20-9
METHYL ACRYLATE 000096-33-3
METHYL CHLORIDE 000074-87-3
METHYL CHLOROCARBONATE 000079-22-1
METHYL ETHYL KETONE 000078-93-3
METHYL ETHYL KETONE PEROXIDE 001338-23-4
METHYL HYDRAZINE 000060-34-4
METHYL ISOBUTYL KETONE 000108-10-1
METHYL ISOCYANATE 000624-83-9
METHYL MERCURY 022967-92-6
METHYL METHACRYLATE 000080-62-6
METHYL PARATHION 000298-00-0
METHYL STYRENE (MIXED ISOMERS) 025013-15-4
METHYL STYRENE, ALPHA 000098-83-9
METHYLAN I LINE, 2- 000095-53-4
METHYLANILINE HYDROCHLORIDE, 2- 000636-21-5
METHYLCHOLANTHRACENE, 3- 000056-49-5
METHYLCYCLOHEXANE 000108-87-2
METHYLENE-BIS(2-CHLOROANILINE), 4,4'-
000101-14-4
HETHYLENE-BIS(N,N'-DIMETHYL)ANILINE, 4,4'-
000101-61-1
METHYLENE BROMIDE 000074-95-3
METHYLENE CHLORIDE / (DICHLOROMETHANE)
000075-09-2
METHYLENE-BIS(BENZENEAMINE), 4,4- /
(METHYLENE DIANILINE, 4,4-) 000101-77-9
METHYLENEDIPHENYL ISOCYANATE, 4,4- /
(DIPHENYLMETHANE DIISOCYANATE) 000101-68-8
2-METHYLLACTONITRILE
2-METHYLPHENOL
3-METHYLPHENOL
4-METHYLPHENOL
METOLACHLOR
METRIBUZIN
MI REX
MOLINATE
MOLYBDENUM
MONOCHLORAMINE
NAPHTHALENE
NAPHTHOQUINONE, 1,4-
NIAGARA BLUE 4B
NICKEL CYANIDE
NICKEL, REFINERY DUST
NICKEL, SOLUBLE SALTS
NICKEL SUBSULFIDE
NICOTINONITRILE
NITRIC OXIDE
NITRITE
NITROANILINE, 2-
NITROANILINE, M-
NITROANILINE, P-
NITROBENZENE
NITROFURANTOIN
NITROFURAZONE
NITROGEN DIOXIDE
NITROGEN OXIDES
NITROMETHANE
NITROPHENOLS
NITROPROPANE, 2-
NITROSO-DI-N-BUTYLAMINE, N-
NITROSO-DI-N-PROPYLAMINE, N-
NITROSO-N-ETHYLUREA, N-
NITROSO-N-METHYLUREA, N-
NITROSODIETHANOLAMINE. N-
NITROSODIETHYLAMINE, N-
NITROSODIMETHYLAMINE, N-
000075-86-5
000095-48-7
000108-39-4
000106-44-5
051218-45-2
021087-64-9
002385-85-5
002212-67-1
007439-98-7
010599-90-3
000091-20-3
000130-15-4
002429-74-5
000557-19-7
NO CASRN
Various
012035-72-2
000100-54-9
010102-43-9
014797-65-0
000088-74-4
000099-09-2
000100-01-6
000098-95-3
000067-20-9
000059-87-0
010102-44-0
NO CASRN
000075-52-5
NO CASRN
000079-46-9
000924-16-3
000621-64-7
000759-73-9
000684-93-5
001116-54-7
000055-18-5
000062-75-9

NAME/CASRN-3
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME) continued
NITROSODIPHENYLAMINE, P-
NITROSODIPHENYLAMINE, N-
NITROSOMETHYLETHYLANINE, N-
NITROSOHETHYLVINYLAMINE, N
NITROSOPYRROLIDIME, N-
NITROTOLUENE, M-
NITROTOLUENE, 0-
NITROTOLUEME, P-
OCTABROMOOIPHENYL ETHER
OCTAMETHYLPYROPHOSPHORAMIDE
OSMIUM TETROXIOE
OZONE
PARALDEHYDE
PARATHION
PART ICULATE MATTER
PEBULATE
PENDIMETHALIN
PENTABROMO-6-CHLOROCYCLOHEXANE.

PENTABROMODIPHENYL ETHER
PENTACHLOROBENZENE
PENTACHLOROCYCLOPENTAOIENE
PENTACHLOROMITROBENZENE
PENTACHLOROPHENOL
PENTACHLOROPROPENE, 1.1,2.3,3,-
PENTANE, N-
PHENANTHRENE
PHENOL
PHENYLENEDIAMINE. M-
PHEMYLENEDIAMINE, 0-
PHENYLENEDIAMINE, P-
PHENYLMERCURIC ACETATE
PHENYLPHENOL. 2-
PHORATE
PHOSGENE
PHOSPHINE
PHOSPHORUS, WHITE
PHOTOCHEMICAL OXIDANTS
PHTHALIC ACID, H-
PHTHALIC ACID, 0-
PHTHALIC ACID, P-
PHTHALIC ANHYDRIDE
POLYBROMINATED BIPHENYLS
POLYCHLORINATED BIPHENYLS
POTASSIUM CYANIDE
POTASSIUM SILVER CYANIDE
PROFLURALIN
PRONAMIDE
000156-10-5 PROPACHLOR 001918-16-7
000086-30-6 PROPAZINE 000139-40-2
010595-95-6 PROPIONITRILE 000107-12-0
004549-40-0 PROPYL ALCOHOL, N- 000071-23-8
000930-55-2 PROPYLENE GLYCOL 000057-55-6
000099-08-1 PROPYLENE GLYCOL MONOETHYL ETHER
000088-72-2 001569-02-4
000099-99-0 PROPYLENE GLYCOL MONOMETHYL ETHER
032536-52-0 000107-98-2
000152-16-9 PROPYLENE OXIDE 000075-56-9
020816-12-0 PYRENE 000129-00-0
010028-15-6 PYRIDINE 000110-86-1
000123-63-7 QUINCLINE 000091-22-5
000056-38-2 RDX / (CYCLONITE) 000121-82-4
NO CASRN RONNEL 000299-84-3
001114-71-2 SELENIOUS ACID 007783-00-8
040487-42-1 SELENIUM 007782-49-2
1,2,3,4,5- SELENIUM SULFIDE 007446-34-6
000087-84-3 SELENOUREA 000630-10-4
032534-81-9 SILVER 007440-22-4
000608-93-5 SILVER CYANIDE 000506-64-9
025329-35-5 SIMAZINE 000122-34-9
000082-68-8 SODIUM CYANIDE 000143-33-9
000087-86-5 SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
001600-37-9 SODIUM METAVANADATE 013718-26-8
000109-66-0 STIROPHOS 000961-11-5
000085-01-8 STRONTIUM, STABLE 007440-24-6
000108-95-2 STRYCHNINE 000057-24-9
000108-45-2 STYRENE 000100-42-5
000095-54-5 SUCCINONITR1LE 000110-61-2
000106-50-3 SULFUR DIOXIDE 007446-09-5
000062-38-4 SULFUR OXIDES NO CASRN
000090-43-7 SULFURIC ACID 007664-93-9
000298-02-2 TCDD. 2.3.7.8- 001746-01-6
000075-44-5 TELONE II 000542-75-6
007803-51-2 TEMEPHOS 003383-96-8
007723-14-0 TERBUFOS 013071-79-9
NO CASRN TEREPHTHALIC ACID 000100-21-0
000121-91-5 TETRACHLOROAZOXYBENZENE 021232-47-3
000088-99-3 TETRACHLOROBENZENE, 1,2,4,5- 000095-94-3
000100-21-0 TETRACHLOROCYCLOPENTADIENE 000695-77-2
000085-44-9 TETRACHLOROETHANE, 1.1,1,2- 000630-20-6
NO CASRN TETRACHLOROETHANE, 1,1,2,2- 000079-34-5
001336-36-3 TETRACHLOROETHYLENE 000127-18-4
000151-50-8 TETRACHLOROHYDRAZOBENZENE 071753-42-9
000506-61-6 TETRACHLOROPHENOL, 2,3,4,5- 004901-51-3
026399-36-0 TETRACHLOROPHENOL, 2,3.4,6- 000058-90-2
023950-58-5 TETRACHLOROPHENOL, 2,3,5,6- 000935-95-5
TETRACHLOROPROPENE, 1,1,2,3-
TETRACHLOROTOLUENE. PARA, ALPHA.

TETRACHLOROVINPHOS / (STIROPHOS)
TETRAETHYL DITHIOPYROPHOSPHATE
THALLIC OXIDE
THALLIUM (I) ACETATE
THALLIUM (I) CARBONATE
THALLIUM (I) CHLORIDE
THALLIUM, INSOLUBLE SALTS
May 1995

010436-39-2
ALPHA, ALPHA-
005216-25-1
000961-11-5
003689-24-5
001314-32-5
000563-68-8
006533-73-9
007791-12-0
NO CASRN
THALLIUM (I) NITRATE
THALLIUM SELENITE
THALLIUM (I) SULFATE
THIOCYANOMETHYLTHIO)BENZOTHIAZOLE,

THIOFANOX
THIOPHENOL
THIRAM
TIN AND COMPOUNDS
TOLUENE
TOLUENE-2.4-DIAMINE
TOLUENE-2,5-DIAHINE
TOLUENE-2.6-DIAMINE
TOLUENEDIAMINE, 2,3-
TOLUENEDIAMINE, 3,4-
TOLUIDINE, M-
TOLUIDINE, P-
TOXAPHENE
TRIALLATE
TRIBROMOBENZENE. 1,2,4-
TRICHLORO-1,2,2-TRIFLUOROETHANE, 1,

TRICHLORO-2'-HYDROXYDIPHENYLETHER,

TRICHLOROANILINE, 2,4,6-
TRICHLOROANILINE HYDROCHLORIDE, 2,4

TRICHLOROBENZENE, 1,2,4-
TRICHLOROCYCLOPENTADIENE
TRICHLOROETHANE, 1,1,1-
TRICHLOROETHANE, 1,1,2-
TRICHLOROETHYLENE
TRICHLOROFLUOROMETHANE
TRICHLOROPHENOL, 2,3,4-
TRICHLOROPHENOL, 2,3,5-
TRICHLOROPHENOL, 2,3,6-
TRICHLOROPHENOL, 2.4.5-
010102-45-1
012039-52-0
007446-18-6
2-(
021564-17-0
013196-18-4
000108-98-5
000137-26-8
NO CASRN
000108-88-3
000095-80-7
000095-70-5
000823-40-5
002687-25-4
000496-72-0
000108-44-1
000106-49-0
008001-35-2
002303-17-5
000615-54-3
1,2-
000076-13-1
2 2 4'-
003380-34-5
000634-93-5
,6-
033663-50-2
000120-82-1
077323-84-3
000071-55-6
000079-00-5
000079-01-6
000075-69-4
015950-66-0
000933-78-8
000933-75-5
000095-95-4
NAME/CASRN-4
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME) continued
Nay 1995
TRICHLOROPHENOL, 2,4,6- 000088-06-2
TRICHLOROPHENOL, 3.4,5- 000609-19-8
TRICHLOROPHENOXY) PROPION1C ACID, 2(2,4,5-
000093-72-1
TRICHLOROPHENOXY ACETIC ACID, 2,4,5-
000093-76-5
TRICHLOROPROPAME, 1.1.1- 007789-89-1
TRICHLOROPROPANE. 1,1,2- 000598-77-6
TRICHLOROPROPAME, 1,2,2- 003175-23-3
TRICHLOROPROPANE, 1,2,3- 000096-18-4
TRICHLOROPROPENE, 1,2,3- 000096-19-5
TRICHLOROTOLUENE, 2,3,6- 002077-46-5
TRICHLOROTOLUENE, ALPHA,2,6- 002014-83-7
TRIFLURALIN 001582-09-8
TRIMETHYL PHOSPHATE 000512-56-1
TRINETHYLBENZENES NO CASRN
TRINITROBENZENE, 1,3,5- 000099-35-4
TRINITROPHENOLS NO CASRN
TRINITROPHENYLMETHYLNITRAMINE 000479-45-8
TRINITROTOLUENE, 2,4,6- 000118-96-7
URANIUM, SOLUBLE SALTS NO CASRN
VANADIUM 007440-62-2
VANADIUM PENTOXIDE 001314-62-1
VANADIUM SULFATE 036907-42-3
VERNAM / (VERNOLATE) 001929-77-7
VERNOLATE 001929-77-7
VINYL-1-CYCLOHEXENE. 4- 000100-40-3
VINYL ACETATE 000108-05-4
VINYL BROMIDE 000593-60-2
VINYL CHLORIDE 000075-01-4
WARFARIN 000081-81-2
XYLENE, M- 000108-38-3
XYLENE, MIXTURE 001330-20-7
XYLENE, 0- 000095-47-6
XYLENE, P- 000106-42-3
ZINC (METALLIC) 007440-66-6
ZINC CYANIDE 000557-21-1
ZINC PHOSPHIDE 001314-84-7
ZIMEB 012122-67-7
NAME/CASRN-5
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER)
000050-00-0 FORMALDEHYDE 000074-11-3
000050-29-3 DDT 000074-83-9
000050-32-8 BENZODUPYRENE 000074-87-3
000051-28-5 DINITROPHENOL, 2,4- 000074-87-3
000053-70-3 DIBENZO[A,H]ANTHRACENE 000074-95-3
000055-18-5 NITROSODIETHYLAMINE, N- 000075-00-3
000056-23-5 CARBON TETRACHLORIDE 000075-01-4
000056-38-2 PARATHION 000075-05-8
000056-49-5 METHYLCHOLANTHRACENE. 3- 000075-09-2
000056-53-1 DIETHYLSTILBESTROL 000075-09-2
000056-55-3 BENZO [A]ANTHRACENE 000075-15-0
000057-12-5 CYANIDE 000075-21-8
000057-14-7 DIMETHYLHYDRAZINE, 1,1- 000075-25-2
000057-24-9 STRYCHNINE 000075-27-4
000057-55-6 PROPYLENE GLYCOL 000075-29-6
000057-74-9 CHLORDANE 000075-34-3
000057-97-6 DIMETHYLBENZ[A]ANTHRACENE, 7,12- 000075-35-4
000058-89-9 HEXACHLOROCYCLOHEXANE, GAMMA- 000075-44-5
000058-90-2 TETRACHLOROPHENOL, 2,3,4,6- 000075-52-5
000059-50-7 CHLORO-M-CRESOL, P- 000075-56-9
000059-87-0 NITROFURAZONE 000075-60-5
000060-29-7 ETHYL ETHER 000075-69-4
000060-34-4 METHYL HYDRAZINE 000075-71-8
000060-51-5 DIHETHOATE 000075-86-5
000060-57-1 DIELDRIN 000075-86-5
000062-38-4 PHENYLMERCURIC ACETATE 000075-87-6
000062-53-3 ANILINE 000075-99-0
000062-75-9 NITROSODIMETHYLAMINE, N- 000076-13-1
000063-25-2 CARBARYL TRICHLORO-
000064-18-6 FORMIC ACID 000076-44-8
000065-85-0 BENZOIC ACID 000077-47-4
000066-56-8 DINITROPHENOL, 2,3- 000077-73-6
000067-20-9 NITROFURANTOIN 000077-78-1
000067-45-8 FURAZOLIDONE 000078-48-8
000067-56-1 METHANOL 000078-59-1
000067-64-1 ACETONE 000078-83-1
000067-66-3 CHLOROFORM 000078-86-4
000067-72-1 HEXACHLOROETHANE 000078-87-5
000068-12-2 DIMETHYLFORMAMIDE, N,N- 000078-93-3
000070-30-4 HEXACHLOROPHENE 000078-97-7
000071-23-8 PROPYL ALCOHOL, N- 000078-99-9
000071-36-3 BUTANOL, 1- 000079-00-5
000071-43-2 BENZENE 000079-01-6
000071-55-6 TRICHLOROETHANE, 1,1,1- 000079-06-1
000072-20-8 ENDRIN 000079-10-7
000072-43-5 METHOXYCHLOR 000079-11-8
000072-54-8 ODD 000079-20-9
000072-55-9 DDE 000079-22-1
CHLOROBENZOIC ACID. P-
BRONOMETHANE
METHYL CHLORIDE
CHLOROMETHANE
METHYLENE BROMIDE
ETHYL CHLORIDE
VINYL CHLORIDE
ACETONITRILE
METHYLENE CHLORIDE
DICHLOROMETHANE
CARBON DISULFIDE
ETHYLENE OXIDE
BROMOFORM
BROMODICHLOROMETHANE
CHLOROPROPANE, 2-
DICHLOROETHANE, 1,1-
DICHLOROETHYLENE, 1,1-
PHOSGENE
NITROMETHANE
PROPYLENE OXIDE
CACODYLIC ACID
TRICHLOROFLUOROMETHANE
DICHLORODIFLUOROMETHANE
2-METHYLLACTONITRILE
ACETONE CYANOHYDRIN
CHLORAL
DALAPON

1,2,2-TRIFLUOROETHANE, 1,1,2-
HEPTACHLOR
HEXACHLOROCYCLOPENTADIENE
DICYCLOPENTADIENE
DIMETHYLSULFATE
MERPHOS OXIDE
ISOPHORONE
ISOBUTYL ALCOHOL
CHLOROBUTANE, 2-
DICHLOROPROPANE, 1,2-
METHYL ETHYL KETONE
LACTONITRILE
DICHLOROPROPANE, 1,1-
TRICHLOROETHANE, 1,1,2-
TRICHLOROETHYLENE
ACRYLAMIDE
ACRYLIC ACID
CHLOROACETIC ACID
METHYL ACETATE
METHYL CHLOROCARBONATE
000079-34-5
000079-46-9
000080-05-7
000080-62-6
000081-81-2
000082-68-8
000083-32-9
000084-66-2
000084-74-2
000085-01-8
000085-44-9
000085-68-7
000086-30-6
000086-73-7
000086-74-8
000087-65-0
000087-68-3
000087-82-1
May 1995

TETRACHLOROETHANE, 1,1,2,2-
NITROPROPANE, 2-
BISPHENOL A
METHYL METHACRYLATE
WARFARIN
PENTACHLORONITROBENZENE
ACENAPHTHENE
DIETHYL PHTHALATE
DIBUTYL PHTHALATE
PHENANTHRENE
PHTHALIC ANHYDRIDE
BUTYL BENZYL PHTHALATE. N-
NITROSODIPHENYLAMINE, N-
FLUORENE
CARBAZOLE
DICHLOROPHENOL, 2,6-
HEXACHLOROBUTADIENE
HEXABROHOBENZENE
000087-84-3
PENTABROMO-6-CHLOROCYCLOHEXANE. 1.2,3,4,5-
000087-86-5
000088-06-2
000088-72-2
000088-73-3
000088-74-4
000088-85-7
000088-99-3
000090-43-7
000091-20-3
000091-22-5
000091-66-7
000091-94-1
000092-52-4
000092-87-5
PENTACHLOROPHENOL
TRICHLOROPHENOL, 2,4,6-
NITROTOLUENE, 0-
CHLORONITROBENZENE, 0-
NITROANILINE, 2-
DINOSEB
PHTHALIC ACID, 0-
PHENYLPHENOL. 2-
NAPHTHALENE
QUINCLINE
DIETHYLANILINE, N,N-
DICHLOROBENZIDINE, 3,3'-
BIPHENYL, 1,1'
BENZIDINE
000093-65-2
METHYL-4-CHLOROPHENOXY) PROPION1C ACID, 2-<2-
000093-71-0 ALLIDOCHLOR
000093-72-1
TR1CHLOROPHENOXY) PROPION1C ACID, 2(2,4,5-
000093-76-5
TRICHLOROPHENOXY ACETIC ACID, 2,4,5-
000094-74-6
METHYL-4-CHLOROPHENOXY ACETIC ACID, 2-
000094-75-7 DICHLOROPHENOXY ACETIC ACID, 2,4-
000094-81-5
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2-
000094-82-6 2,4-DB
000094-82-6
CASRN/NAME-1
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER) continued
Hay 1995
OICHLOROPHENOXY) BUTYRIC ACID, 4-(2,4-
000095-47-6 XYLENE, 0-
000095-48-7 CRESOL, 0-
000095-48-7 2-METHYLPHENOL
000095-49-8 CHLOROTOLUENE, 0-
000095-50-1 OICHLOROBENZENE, 1,2-
000095-51-2 CHLOROANILINE, 2-
000095-53-4 METHYLANIL1NE, 2-
000095-54-5 PHENYLENEDIAMINE. 0-
000095-55-6 AMINOPHENOL, 0-
000095-57-8 CHLOROPHENOL, 2-
000095-65-8 OIMETHYLPHENOL, 3.4-
000095-68-1 DIMETHYLANILINE, 2.4-
000095-69-2 CHLORO-2-HETHYLANILINE, 4-
000095-70-5 TOLUENE-2.5-DIAMINE
000095-77-2 DICHLOROPHENOL, 3,4-
000095-80-7 TOLUENE-2.4-DIAMINE
000095-87-4 DIHETHYLPHENOL, 2,5-
000095-94-3 TETRACHLOROBENZENE, 1,2,4,5-
000095-95-4 TRICHLOROPHENOL, 2,4,5-
000096-12-8 OIBROMO-3-CHLOROPROPANE, 1,2
000096-18-4 TRICHLOROPROPANE, 1,2,3-
000096-19-5 TRICHLOROPROPENE, 1,2,3-
000096-33-3 METHYL ACRYLATE
000096-45-7 ETHYLENE THIOUREA
000096-48-0 BUTYROLACTONE, GAMMA-
000097-63-2 ETHYL METHACRYLATE
000098-01-1 FURFURAL
000098-07-7 BENZOTRICHLORIDE
000098-56-6 CHLOROBENZOTRIFLUORIDE, 4-
000098-82-8 CUMENE
000098-83-9 METHYL STYRENE, ALPHA
000098-86-2 ACETOPHENONE
000098-87-3 BENZAL CHLORIDE
000098-95-3 NITROBENZENE
000099-08-1 NITROTOLUENE, M-
000099-09-2 NITROANILINE. M-
000099-35-4 TRINITROBENZENE, 1.3,5-
000099-55-8 METHYL-5-NITROANILINE, 2-
000099-59-2 METHOXY-5-NITROANILINE, 2-
000099-65-0 DINITROBENZENE, 1.3-
000099-99-0 NITROTOLUENE, P-
000100-00-5 CHLORONITROBENZENE, P-
000100-01-6 NITROANILINE, P-
000100-21-0 PHTHALIC ACID, P-
000100-21-0 TEREPHTHALIC ACID
000100-25-4 DINITROBENZENE, 1,4-
000100-40-3 VINYL-1-CYCLOHEXENE, 4-
000100-41-4 ETHYL BENZENE
000100-42-5 STYRENE
000100-44-7 BENZYL CHLORIDE
000100-51-6 BENZYL ALCOHOL
000100-52-7 BENZALDEHYDE
000100-54-9 NICOT1NONITRILE
000101-14-4
METHYLENE-BIS(2-CHLOROANIL1NE), 4,4'-
000101-55-3 BROMOPHENYL PHENYL ETHER, 4-
000101-61-1
METHYLENE-BIS(N,N'-DIMETHYL)ANILINE, 4,4'-
000101-68-8 DIPHENYLMETHANE DIISOCYANATE
000101-68-8
METHYLENEDIPHENYL ISOCYANATE, 4,4-
000101-77-9 METHYLENE-BIS(BENZENEAMINE), 4.4-
000103-33-3 AZOBENZENE
000103-69-5 ETHYLANILINE, N-
000105-60-2 CAPROLACTAM
000105-67-9 DIMETHYLPHENOL, 2,4-
000106-13-8 ETHOXYETHANOL DODECANOATE, 2-
000106-37-6 DIBROMOBENZENE, 1,4-
000106-42-3 XYLENE, P-
000106-43-4 CHLOROTOLUENE, P-
000106-44-5 4-METHYLPHENOL
000106-44-5 CRESOL, P-
000106-46-7 DICHLOROBENZENE, 1,4-
000106-47-8 CHLOROANILINE, 4-
000106-48-9 CHLOROPHENOL, 4-
000106-49-0 TOLUIDINE, P-
000106-50-3 PHENYLENEDIAMINE, P-
000106-74-1 ETHOXYETHANOL ACRYLATE, 2-
000106-89-8 EPICHLOROHYORIN
000106-93-4 DIBROMOETHANE, 1,2-
000106-99-0 BUTADIENE, 1,3-
000107-02-8 ACROLEIN
000107-05-1 ALLYL CHLORIDE
000107-06-2 DICHLOROETHANE, 1,2-
000107-12-0 PROPIONITRILE
000107-13-1 ACRYLONITRILE
000107-15-3 ETHYLENE DIAMINE
000107-16-4 FORMALDEHYDE CYANOHYDRIN
000107-18-6 ALLYL ALCOHOL
000107-20-0 CHLOROACETALDEHYDE
000107-21-1 ETHYLENE GLYCOL
000107-30-2 CHLOROMETHYL METHYL ETHER
000107-98-2 PROPYLENE GLYCOL MONOMETHYL ETHER
000108-05-4 VINYL ACETATE
000108-10-1 METHYL ISOBUTYL KETONE
000108-31-6 MALE 1C ANHYDRIDE
000108-38-3 XYLENE, M-
000108-39-4 3-METHYLPHENOL
000108-39-4 CRESOL. M-
000108-41-8 CHLOROTOLUENE. M-
000108-42-9 CHLOROANILINE, 3-
000108-43-0 CHLOROPHENOL, 3-
000108-44-1 TOLUIDINE, M-
000108-45-2 PHENYLENEDIAMINE, H-
000108-87-2 METHYLCYCLOHEXANE
000108-88-3 TOLUENE
000108-90-7 CHLOROBENZENE
000108-91-8 CYCLOHEXYLAMINE
000108-93-0 CYCLOHEXANOL
CASRN/NAME-2
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER) continued
000108-95-2 PHENOL 000123-33-1
000108-98-5 THIOPHENOL 000123-63-7
000108-98-5 BENZENETHIOL 000123-73-9
000108-06-1 BIS(2-CHLORO-1-METHYLETHYL) ETHER 000123-91-1
000109-66-0 PENTANE, N- 000124-09-4
000109-69-3 CHLOROBUTANE, 1- 000124-48-1
000109-77-3 MALONONITRILE 000126-98-7
000109-78-4 ETHYLENE CYANOHYDRIN 000126-99-8
000109-86-4 METHOXYETHANOL, 2- 000126-99-8
000110-00-9 FURAN 000127-18-4
000110-49-6 METHOXYETHANOL ACETATE, 2- 000129-00-0
000110-54-3 HEXANE, N- 000130-15-4
000110-61-2 SUCC1NONITR1LE 000131-11-3
000110-80-5 ETHOXYETHAMOL, 2- 000132-64-9
000110-86-1 PYR1D1ME 000133-06-2
000111-15-9 ETHOXYETHANOL ACETATE, 2- 000133-07-3
000111-44-4 BIS(2-CHLOROETHYL) ETHER 000137-26-8
000111-69-3 ADIPONITRILE 000139-40-2
000111-76-2 ETHYLENE GLYCOL NONOBUTYL ETHER 000140-57-8
000111-90-0 DIETHYLENE GLYCOL HONOETHYL ETHER 000140-88-5
000112-34-5 OIETHYLENE GLYCOL NONOBUTYL ETHER 000141-78-6
000115-29-7 ENOOSULFAN 000142-28-9
000116-06-3 ALDICARB 000142-82-5
000117-81-7 BIS(2-ETHYLHEXYL) PHTHALATE 000143-33-9
000117-81-7 DEHP 000145-73-3
000117-84-0 DI-N-OCTYL PHTHALATE 000148-18-5
000118-74-1 HEXACHLOROBENZENE 000150-50-5
000118-75-2 CHLORANIL 000151-50-8
000118-96-7 TRINITROTOLUENE, 2,4,6- 000152-16-9
000119-90-4 DIMETHOXYBENZIDIME, 3,3'- 000156-10-5
000119-93-7 DIHETHYLBENZIDINE, 3,3'- 000156-59-2
000120-12-7 ANTHRACENE 000156-60-5
000120-36-5 DICHLORPROP 000193-39-5
000120-61-6 DIMETHYLTEREPHTHALATE 000205-99-2
000120-82-1 TRICHLOROBENZENE, 1,2,4- 000206-44-0
000120-83-2 DICHLOROPHENOL, 2,4- 000207-08-9
000121-14-2 OINITROTOLUENE, 2,4 000208-96-8
000121-69-7 DINETHYLANILINE, N,N- 000218-01-9
000121-73-3 CHLORONITROBENZENE, M- 000298-00-0
000121-75-5 HALATHION 000298-02-2
000121-82-4 CYCLONITE 000298-04-4
000121-82-4 RDX 000299-84-3
000121-91-5 PHTHALIC ACID, H- 000302-01-2
000122-34-9 SIHAZINE 000304-61-0
000122-39-4 D1PHENYLAMINE, N.N- 000309-00-2
000122-66-7 DIPHENYLHYORAZINE, 1,2- 000311-45-5
000123-30-8 AMINOPHENOL, P- 000319-84-6
000123-31-9 HYOROQUINONE 000319-85-7
MALE 1C HYDRAZIDE 000319-86-8
PARALOEHYDE 000329-71-5
CROTONALOEHYDE 000330-55-2
DIOXANE, 1.4- 000333-41-5
HEXAHETHYLENE DIAHINE 000460-19-5
DIBROMOCHLOROMETHANE 000479-45-8
METHACRYLONITRILE 000496-72-0
CHLORO-1,3-BUTADIENE, 2- 000504-24-5
CHLOROPRENE 000506-61-6
TETRACHLOROETHYLENE 000506-64-9
PYRENE 000506-68-3
NAPHTHOQUINONE, 1,4- 000506-77-4
OIMETHYLPHTHALATE 000507-20-0
OIBENZOFURAN 000510-15-6
CAPTAN 000512-56-1
FOLPET 000526-75-0
THIRAM 000528-29-0
PROPAZINE 000531-82-8
ARAHITE 000532-28-5
ETHYL ACRYLATE 000534-52-1
ETHYL ACETATE
OICHLOROPROPANE, 1,3- 000540-73-8
HEPTANE. N- 000541-73-1
SODIUM CYANIDE 000542-62-1
ENDOTHALL 000542-75-6
SODIUM DIETHYLDITHIOCARBAMATE 000542-75-6
MERPHOS 000542-88-1
POTASSIUM CYANIDE 000542-92-7
OCTAMETHYLPYROPHOSPHORAMIDE 000544-92-3
NITROSODIPHENYLAMINE, P- 000557-19-7
DICHLOROETHYLENE, 1,2-C- 000557-21-1
DICHLOROETHYLENE, 1,2-T- 000563-68-8
INDENOM.2.3-CD1PYRENE 000573-56-8
BENZOCB1FLUORANTHENE 000576-24-9
FLUORANTHENE 000576-26-1
BENZOCK1FLUORANTHENE 000583-78-8
ACENAPTHYLENE 000586-11-8
CHRYSENE 000591-27-5
METHYL PARATHION 000591-35-5
PHORATE 000591-78-6
DISULFOTON 000592-01-8
RONNEL 000593-60-2
HYDRAZINE 000593-60-2
ANTIMONY POTASSIUM TARTRATE 000594-20-7
ALDRIH 000598-31-2
DIETHYL-P-NITROPHENYL PHOSPHATE 000598-77-6
HEXACHLOROCYCLOHEXANE. ALPHA- 000598-94-7
HEXACHLOROCYCLOHEXANE, BETA- 000602-01-7
Nay 1995

HEXACHLOROCYCLOHEXANE, DELTA-
DINITROPHENOL, 2,5-
LINURON
DIAZINON
CYANOGEN
TRINITROPHENYLMETHYLNITRANINE
TOLUENEDIAMINE, 3,4-
AMINOPYRIDINE, 4-
POTASS1UM SILVER CYANIDE
SILVER CYANIDE
CYANOGEN BROMIDE
CHLORINE CYANIDE
BUTYLCHLORIOE, T-
CHLOROBENZILATE
TRIMETHYL PHOSPHATE
D1METHYLPHENOL, 2,3-
DINITROBENZENE, 1,2-
FURIUM
BENZALDEHYDE CYANOHYDRIN
DINITRO-0-CRESOL, 4.6-
000540-59BOCHLOROETHYLENE. 1,2- (NIXED ISONERS)
DIMETHYLHYDRAZINE, 1,2-
DICHLOROBENZENE. 1.3-
BAR1UM CYANIDE
TELONE II
DICHLOROPROPENE, 1,3-
BIS(CHLOROMETHYL) ETHER
CYCLOPENTAOIENE
COPPER CYANIDE
NICKEL CYANIDE
ZINC CYANIDE
THALLIUM (I) ACETATE
DINITROPHENOL, 2,6-
DICHLOROPHENOL, 2,3-
DIMETHYLPHENOL, 2,6-
DICHLOROPHENOL, 2,5-
DINITROPHENOL, 3,5-
AMINOPHENOL, N-
DICHLOROPHENOL, 3,5-
HEXANONE, 2-
CALCIUM CYANIDE
VINYL BROMIDE
BROMOETHENE
DICHLOROPROPANE, 2,2-
BROMOACETONE
TRICHLOROPROPANE, 1.1,2-
DIMETHYLUREA, N,N-
DINITROTOLUENE, 2,3-
CASRN/NAME-3
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER) continued
May 1995
000606-20-2 DINITROTOLUENE, 2,6-
000608-73-1 HEXACHLOROCYCLONEXANE-TECHNICAL
000608-93-5 PENTACNLOROBENZENE
000609-19-8 TRICHLOROPHENOL, 3,4.5-
000609-93-8 DINITRO-P-CRESOL. 2,6-
000610-39-9 DINITROTOLUENE. 3.4-
000611-14-3 ETHYLTOLUENE. 0-
000615-54-3 TRIBROHOBENZENE. 1.2.4-
000617-84-5 DIETHYLFORMAMIDE
000619-15-8 DINITROTOLUENE, 2.5-
000620-14-4 ETHYLTOLUENE, N-
000621-64-7 NITROSO-DI-N-PROPYLAMINE. N-
000622-96-8 ETHYLTOLUENE, P-
000624-83-9 METHYL ISOCYANATE
000630-05-0 CARBON MONOXIDE
000630-10-4 SELENOUREA
000630-20-6 TETRACHLOROETHANE, 1.1,1,2-
000634-93-5 TRICHLOROANILIHE. 2,4.6-
000636-21-5 METHYLANILINE HYDROCHLORIDE, 2-
000684-93-5 NITROSO-N-METHYLUREA. N-
000695-77-2 TETRACHLOROCYCLOPENTADIENE
000759-73-9 NITROSO-N-ETHYLUREA. N-
000759-94-4 EPTC
000764-41-0 DICHLORO-2-BUTENE, 1,4-
000765-34-4 GLYCIDALDEHYDE
000823-40-5 TOLUENE-2.6-DIANINE
000834-12-8 ANETRYH
000924-16-3 NITROSO-DI-N-BUTYLAMINE, N-
000930-55-2 NITROSOPYRROLIDINE, N-
000933-75-5 TRICHLOROPHENOL. 2.3,6-
000933-78-8 TRICHLOROPHENOL. 2,3,5-
000934-80-5 ETHYL-0-XYLEHE. 4-
000935-95-5 TETRACHLOROPHENOL. 2,3,5,6-
000950-10-7 MEPHOSFOLAN
000961-11-5 TETRACHLOROVINPHOS
000961-11-5 STIROPHOS
001024-57-3 HEPTACHLOR EPOXIDE
001114-71-2 PEBULATE
001116-54-7 NITROSODIETHANOLAMINE. N-
001134-23-2 CYCLOATE
001163-19-5 DECABROMODIPHENYL ETHER
001198-27-2 ANINO-2-NAPHTOL HYDROCHLORIDE, 1-
001309-64-4 ANTIMONY TRIOXIDE
001314-32-5 THALLIC OXIDE
001314-60-9 ANTIMONY PENTOXIDE
001314-62-1 VANADIUM PENTOXIDE
001314-84-7 ZINC PHOSPHIDE
001330-20-7 XYLEHE, MIXTURE
001332-21-4 ASBESTOS
001332-81-6 ANTIMONY TETROXIDE
001336-36-3 POLYCHLORINATEO BIPHENYLS
001338-23-4 METHYL ETHYL KETONE PEROXIDE
001563-66-2 CARBOFURAN
001569-02-4 PROPYLENE GLYCOL MONOETHYL ETHER
001582-09-8 TRI PLURAL IN
001600-37-9 PENTACHLOROPROPENE, 1.1,2,3,3.-
001615-80-1 DIETHYLHYDRAZINE. 1.2-
001689-84-5 001689-99-2BROMOXYN1L OCTANOATE
001746-01-6 TCDD, 2.3,7.8-
001861-32-1 DACTHAL
001861-40-1 BENEF1N
001897-45-6 CHLOROTHALONIL
001912-24-9 ATRAZINE
001918-00-9 DICAMBA
001918-16-7 PROPACHLOR
001929-77-7 VERNOLATE
001929-77-7 VERNAM
001937-37-7 DIRECT BLACK 38
002008-41-5 BUTYLATE
002014-83-7 TRICHLOROTOLUENE. ALPHA,2,6-
002077-46-5 TRICHLOROTOLUENE, 2.3,6-
002104-96-3 BROMOPHOS
002212-67-1 MOLINATE
002303-16-4 DIALLATE
002303-17-5 TR1ALLATE
002370-63-0 ETHOXYETHYL METHACRYLATE, 2-
002385-85-5 MIREX
002425-06-1 CAPTAFOL
002429-74-5 NIAGARA BLUE 4B
002491-38-5 BUSAN 90
002602-46-2 DIRECT BLUE 6
002610-05-1 DIRECT SKY BLUE 6B
002687-25-4 TOLUENEDIAMINE. 2,3-
002834-92-6 AMINO-2-NAPHTHOL, 1-
002921-88-2 CHLORPYR1FOS
003165-93-3
CHLORO-2-METHYLANILINE HYDROCHLORIDE, 4-
003175-23-3 TRICHLOROPROPANE, 1,2.2-
003380-34-5
TRICHLORO-2'-HYDROXYDIPHENYLETHER, 2,2,4'-
003383-96-8
003689-24-5
004399-55-7
004549-40-0
004901-51-3
005216-25-1
TEMEPHOS
TETRAETHYL DITHIOPYROPHOSPHATE
DIRECT L1GHTFAST BLUE
NITROSOMETHYLVINYLAM1NE, N
TETRACHLOROPHENOL, 2,3.4,5-
TETRACHLOROTOLUENE, PARA. ALPHA, ALPHA, ALPHA-
005598-13-0 CHLORPYRIFOS METHYL
006108-10-7 HEXACHLOROCYCLOHEXANE. EPSILON-
006533-73-9 THALLIUM (I) CARBONATE
007429-90-5 ALUMINUM
007439-89-6 IRON
007439-92-1 LEAD
007439-96-5 MANGANESE
007439-97-6 MERCURY, ELEMENTAL
007439-98-7 MOLYBDENUM
007440-22-4 SILVER
007440-24-6 STRONTIUM, STABLE
007440-36-0 ANTIMONY, METALLIC
007440-38-2 ARSENIC, INORGANIC
007440-39-3 BARIUM
007440-41-7 BERYLLIUM
007440-42-8 BORON, ELEMENTAL
007440-43-9 CADMIUM
007440-50-8 COPPER
007440-62-2 VANADIUM
007440-66-6 ZINC (METALLIC)
007446-09-5 SULFUR DIOXIDE
007446-18-6 THALLIUM (I) SULFATE
007446-34-6 SELENIUM SULFIDE
007487-94-7 MERCURIC CHLORIDE
007637-07-2 BORON TRIFLUORIDE
007664-41-7 AMMONIA
007664-93-9 SULFUR1C ACID
007723-14-0 PHOSPHORUS, WHITE
007782-41-4 FLUORINE / (SOLUBLE FLUORIDE)
007782-49-2 SELENIUM
007783-00-8 SELENIOUS ACID
007783-06-4 HYDROGEN SULFIDE
007789-89-1 TRICHLOROPROPANE, 1,1,1-
007791-12-0 THALLIUM (I) CHLORIDE
007803-51-2 PHOSPHINE
008001-35-2 TOXAPHENE
008001-58-9 CREOSOTE, COAL TAR
008007-45-2 COKE OVEN EMISSIONS
008018-01-7 MANCOZEB
010028-15-6 OZONE
010034-93-2 HYDRAZINE SULFATE
010102-43-9 NITRIC OXIDE
010102-44-0 NITROGEN DIOXIDE
010102-45-1 THALLIUM (I) NITRATE
010436-39-2 TETRACHLOROPROPENE, 1,1,2,3-
010595-95-6 NITROSOMETHYLETHYLAMINE, N-
010599-90-3 MONOCHLORAMINE
CASRN/NAME-4
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER) continued
Nay 1995
011097-69
012035-72
012039-52
012122-67
012427-38
012672-29
013071-79
013194-48
013196-18
013718-26
014797-65
015950-66
015972-60
016065-83
016071-86
016752-77
018540-29
020816-12
020859-73
021087-64
021232-47
021436-96
021564-17

021725-46
022967-92
023950-58
025013-15
025329-35
026399-36
030560-19
031512-74
032534-81
032536-52
033663-50

033820-53
036907-42
039638-32
040487-42
041851-50
051218-45
059756-60
060238-56
068554-00
071753-42
077323-84
VARIOUS
1 AROCLOR 1254 NO CASRN
2 NICKEL SUBSULFIDE NO CASRN
0 THALLIUM SELENITE NO CASRN
7 ZINEB NO CASRN
-2 NANEB NO CASRN
6 AROCLOR 1248 VARIOUS
9 TERBUFOS NO CASRN
4 ETHOPROP NO CASRN
-4 THIOFANOX NO CASRN
-8 SODIUM NETAVANADATE NO CASRN
-0 NITRITE NO CASRN
-0 TRICHLOROPHENOL, 2,3,4- NO CASRN
-8 ALACHLOR NO CASRN
-1 CHRONIUN(III) NO CASRN
i-6 DIRECT BROUN 95 NO CASRN
'-5 NETHONYL NO CASRN
-9 CHROMIUM(VI) NO CASRN
0 OSMIUM TETROXIDE
-8 ALUMINUM PHOSPHIDE
-9 METRIBUZIN
-3 TETRACHLOROAZOXYBENZENE
-4 DIMETHYLANILINE HYDROCHLORIDE, 2.4-
-0
THIOCYANOMETHYLTHIO)BENZOTHIAZOLE, 2-(
CYANAZINE
METHYL MERCURY
PRONAMIDE
METHYL STYRENE (MIXED ISGMERS)
PENTACHLOROCYCLOPENTADIENE
PROFLURALIN
ACEPHATE
BUSAN 77
PENTABROMODIPHENYL ETHER
OCTABROMODIPHENYL ETHER
-2
-6
-5
-4
-5
-0
-1
-0
-9
-0
-2
TRICHLOROANILINE HYDROCHLORIDE, 2.4,6-
-0 ISOPROPALIN
-3 VANADIUM SULFATE
-9 BIS(2-CHLOROISOPROPYL) ETHER
-1 PENDIMETHALIN
-7 CHLOROCYCLOPENTADIENE
-2 METOLACHLOR
-4 FLURIDONE
-4 CHLORTHIOPHOS
-7 ETHOXYETHANOL PHOSPHATE, 2-
-9 TETRACHLOROHYDRAZOBENZENE
-3 TRICHLOROCYCLOPENTADIENE
BROMIMATED DIBENZOFURANS
BROMINATED DIBENZO-P-DIOXINS
BROMOCHLOROETHANES
DICHLOROBUTENES
LEAD ALKYLS
NICKEL. REFINERY DUST
NICKEL. SOLUBLE SALTS
NITROGEN OXIDES
NITROPHENOLS
PARTICIPATE MATTER
PHOTOCHEMICAL OXIDANTS
POLYBROMINATED BIPHENYLS
SULFUR OXIDES
THALLIUM, INSOLUBLE SALTS
TIN AND COMPOUNDS
TRIMETHYLBENZENES
TRINITROPHENOLS
URANIUM, SOLUBLE SALTS
CASRN/NAME-5
-------
APPENDIX A-IV

IV. EFFECT LEVEL DEFINITIONS
Adverse effect. A biochemical change, functional impairment, or pathologic lesion that
either singly or in combination adversely affects the performance of the whole
organism, or reduces an organism's ability to respond to an additional environmental
challenge.

Frank-effect-level (FELV The exposure level at which there are statistically or
biologically significant increases in frequency or severity of severe effects between the
exposed population and its appropriate control group. These severe effects produce an
unmistakable adverse health effect (such as severe convulsions or death).

Lowest-observed-adverse-effect level (LOAEU. The lowest exposure level at which
there are statistically or biologically significant increases in frequency or severity of
adverse effects between the exposed population and its appropriate control group.

Lowest-observed-effect level (LOEL). The lowest exposure level at which there are
statistically or biologically significant increases in frequency or severity of any effects
between the exposed population and its appropriate control group. The effects that are
seen at this level may or may not be considered as adverse.

No-observed-adverse-effect level (NOAEL). An exposure level at which there are no
statistically or biologically significant increases in the frequency or severity of adverse
effects between the exposed population and its appropriate control; some effects may
be produced at this level, but they are not considered to be adverse.

No-Qbserved-effect level (NOELV An exposure level at which there are no statistically
or biologically significant increases in the frequency or severity of any effect between
the exposed population and its appropriate control.
Adapted from: U.S. EPA. 1991. Integrated Risk Information System (IRIS). Online.
National Center for Environmental Assessment, Cincinnati, OH.
A-21
-------
APPENDIX A-V

V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
The Clean Air Act requires that National Ambient Air Quality Standards (NAAQS)
be set and ultimately met for any air pollutant which, if present in air, may reasonably be
anticipated to endanger public health or welfare and whose presence in the air results
from numerous or diverse mobile and/or stationary sources. Since the primary NAAQS
and the inhalation RfC serve essentially the same function, and the primary NAAQS
have extensive data bases rigorously reviewed, the primary NAAQS with annual
averaging times should be used in lieu of an inhalation RfC, except for lead. In deriving
a risk assessment number for lead (Pb), the Integrated Exposure Uptake Biokinetics
(IEUBK) model should be used instead of the RfC. Primary standards are designed to
protect public health and secondary standards are designed to protect public welfare.
Each primary NAAQS has either one or two averaging times depending on the health
effects of the chemical. To date, six NAAQS have been established: Carbon Monoxide
(CO), Lead (Pb), Nitrogen Dioxide (NO2), Particuiate Matter, less than 10 Mm in size,
(PM10), Ozone (O3) and Sulfur Dioxide (SO2). A table of the most recent NAAQS is
provided as Table A-V-1.

The process of establishing and revising the NAAQS is detailed by Padgett and
Richmond (Journal of the Air Pollution Control Association, 33:13-16, 1983). The
primary NAAQS are solely health based and designed to protect the most sensitive
group of individuals (but not necessarily the most sensitive members of that group)
against adverse health effects. Thus, by definition, the NAAQS primary standards
define allowable pollutant concentrations which can be present in the atmosphere
without causing adverse effects, and essentially serve the same function as an
inhalation RfC in a risk assessment/risk management decision, except for lead. The
data bases supporting each of the NAAQS are extensive. More importantly, the
NAAQS are set by the USEPA Administrator as mandated by Congress after numerous
reviews and a public comment process.
A-23
-------
TABLE A-V-1
NATIONAL AMBIENT AIR QUALITY STANDARDS'
(as of December 2, 1991)
Pollutant
Carbon monoxide (CO)
Lead (Pb)
(and Lead compounds
Nitrogen dioxide (N02)
(Nitrogen oxide)
(Nitric oxide)
Particulate Matter
(PM10)
Ozone (O3)
Sulfur dioxide (SO2)
(Sulfur oxide)
Primary Standards"
9 ppm (10 mg/m3)
35 ppm (40 mg/m3)
1.5 Mg/m3
0.053 ppm
(100 Mg/m3)
50 pg/m3
150 Mg/m3
0.12 ppm
(235 Mg/m3)
0.03 ppm
(80 Mg/m3)
0.14 ppm
(365 Mg/m3)
—
Averaging
Time
8 hour0
1 hour0
Quarterly
Annual
Annual"
24 hours6
1 hourf
Annual
24 hours0
3 hours0
Secondary
Standards'1
None
Same as primary
Same as primary
Same as primary
Same as primary
» —
—
0.5 ppm
(1300M9/m3)
•Source: U.S. EPA 1991. Subchapter C - Air Programs. Part 50 -National Primary and
Secondary Ambient Air Quality Standards. Code of Federal Regulations 50: 693-697.
Revised 7/1/91.

"Primary standards are designed to protect public health; Secondary standards are designed to
protect public welfare.

°Not to be exceeded more than once per year.

''The standard is attained when the expected annual arithmetic mean concentration is less than
or equal to 50
The standard is attained when the expected number of days per calendar year with a 24-hour
average concentration above 150 Mg/m3 is equal to or less than 1.

The standard is attained when the expected number of days per calendar year with maximum
hourly average concentrations above 0.12 ppm is equal to or less than 1.
A-24
•U.S. GOVERNMENT PRINTING OFFICE: 1995-386-541/23016
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Library
Environmental
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