&EPA
           United States
           Environmental Protection
           Agency
                Office of
                Solid Waste and
                Emergency Response
9200.6-303(95-1)
EPA/540/R-95/036//
PB95-921199
May 1995
           Superfund
Health Effects Assessment
Summary Tables

FY-1995 Annual

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                                            9200.6-303(95-1)
                                           EPA 540/R-95-036
                                               PB95-921199
                                                  May 1995
    HEALTH EFFECTS ASSESSMENT

          SUMMARY TABLES


            FY-1995 Annual
        U S Environmental Protection Agency
        Region 5, Library (PL-12J)
        77 West Jackson Boulevard, IZtn Moor
        Chicago, IL  60604-3590
    Office of Research and Development
Office of Emergency and Remedial Response
   U.S. Environmental Protection Agency
         Washington, DC 20460

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                                   DISCLAIMER
      This report has been prepared by the U.S. Environmental Protection Agency. The
information contained herein has been taken from final documents prepared by the Office of
Health and Environmental Assessment (hereafter referred to as the National Center for
Environmental Assessment) for the Office of Solid Waste and Emergency Response and the
Office of Water, Washington, DC and the Office of Air Quality Planning and Standards,
Research Triangle Park, NC. These documents were reviewed in accordance with Agency
policy and approved for publication.  Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.

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                                   INTRODUCTION

       This document is the FY95 Annual Update of the Health Effects Assessment Summary
 Tables (HEAST) prepared by EPA's National Center for Environmental Assessment, Cincinnati,
 OH (NCEA-CIN) for use at both Superfund and RCRA sites. It completely replaces all former
 editions and supplements of the HEAST.
       This version of the HEAST will be updated by a November 1995 Supplement. The
 supplement will supercede the information in this document, the May 1995 HEAST Annual
 Update.  Therefore, if the supplement is available it should be checked whenever this document
 is consulted.  The supplement, however, will not be produced to stand alone and will not
 contain the User's Guides or Appendix that are available in the annual update. Thus, the user
 should refer to the May 1995 HEAST Annual Update for this information.
       The HEAST is a comprehensive listing consisting almost entirely of PROVISIONAL
 RISK ASSESSMENT INFORMATION relative to oral and inhalation routes for chemicals of
 interest to Superfund, the Resource Conservation and Recovery Act (RCRA), and the EPA in
 general.  These entries in the HEAST are limited to chemicals that have undergone review and
 have the  concurrence of individual Agency Program Offices,  and each is supported by an
 Agency reference. This risk assessment information has not, however, had enough review to
 be recognized as high quality, Agency-wide consensus information.
       The Integrated Risk Information System (IRIS) is the Agency's official repository of
Agency-wide consensus chronic human health risk information. IRIS evaluations are
conducted by the Agency's Work Group Review process, i.e., they have been examined by
either the Reference Dose/Reference Concentration (RfD/RfC) Work Group or the Carcinogen
Risk Assessment Verification Endeavor (CRAVE) Work Group.  These Agency Work Groups
conduct a process that leads to internal Agency scientific consensus regarding risk assessment

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information on a chemical. This information is recorded on IRIS, is considered to be "Work

Group Verified," and does not appear on the HEAST. Thus, provisional risk assessment             fl

information on the HEAST is subject to possible review and revision by these Agency Work

Groups.

       There are two exceptions to the above discussion.  The HEAST also contains

information on chemicals that are a part of the National Ambient Air Quality Standards

(NAAQS) or the Drinking Water Criteria Document (DWCD) series.  In each of these cases, the

chemicals are subject to extensive scientific peer review processes of extremely high quality.
CHEMICAL STATUS DEFINITIONS

       Chemicals reviewed by the Agency Work Groups are classified according to their status

as either "verified," "not verifiable," or "under review."  The toxicity values (other than NAAQS or

DWCD values) listed on the HEAST are considered to be "provisional." The Agency has no

official definitions for these terms, but the HEAST user may interpret them as follows:

       Provisional: A toxicity value or a cancer value is "provisional" if the value has
       had some form of Agency review, but it does not appear on the IRIS system.
       These values are generated in several ways. Often they are determined in the
       course of developing an Agency document on a chemical or on a class of
       chemicals. Some have been generated through the Work Group process, but
       have not yet been input to the IRIS system. At the time each value was derived,
       all available information on the chemical was evaluated, the value was calculated
       using the most current methodology, and a consensus was reached on the value
       by Agency scientists.

       Brackets are placed around the names of toxicity and carcinogenicity values on
       the HEAST to distinguish these "provisional" values from information on IRIS.
       The following names are  affected:  RfD to [RfD], RfC to [RfC], slope factor to
       [slope factor], EPA group to [EPA Group] and  unit risk to [unit risk].

       These "provisional" values are found on the HEAST.  They do not appear
       on IRIS.

       Verified: A toxicity value or a cancer value is "Work Group Verified" if all
       available information on the value has been examined by an Agency Work
       Group, the value has been calculated using current Work Group methodology, a
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       unanimous consensus has been reached on the value by the Work Group, and
       the value appears on IRIS.

       Some numbers that have achieved unanimous concensus by the Work Group
       may appear on the HEAST for a short time until they are loaded onto IRIS, at
       which time they are termed, "verified." During the interim, they are considered to
       be "provisional" values that are still "under review" by the Work Group.

       These "verified" numbers only appear on IRIS. They do not appear on the
       HEAST.

       Not verifiable: A toxicity value is "not verifiable" if an Agency Work Group has
       considered all available data on a chemical and has unanimously determined
       that data are inadequate to generate a value that would be suitable for inclusion
       on IRIS. No toxicity value is calculated; no toxicity value is available for IRIS or
       the HEAST.

       This "not verifiable" status is noted on IRIS, and is sometimes found on
       the HEAST, with a pointer to the IRIS system.

       Under Review: A toxicity value is "under review" if an Agency Work Group is in
       the process of considering all available data on a chemical.  All Work Group
       chemicals will have this status until the toxicity value is placed on the IRIS
       system. Toxicity values that have been withdrawn from IRIS by a Work Group
       for further review will have this status.

       This "under review" status may be indicated on IRIS or on the HEAST.
       During this time, "provisional" toxicity values may appear on the HEAST.
       In all cases, the status of a chemical may change as new data become available, and

the assessment is revisited.



CAUTION

       It is imperative for each user of the HEAST to recognize that the values listed in the

toxicity tables and the cancer table are generally considered to be PROVISIONAL RISK

ASSESSMENT INFORMATION. The user is referred to IRIS for "Work Group Verified" values.

It is also important to remember that the numbers  in these tables alone tell very little about the

adverse effects of a chemical or the quality of evidence on which risk assessment information is

based. Original assessment documents must be consulted by users of the HEAST in order to
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fully appreciate the strengths and limitations of a specific data base. Original source
documents will allow for the most complete characterization of potential toxicity associated with
the range of exposure pathways generally evaluated at Superfund and RCRA sites.  The
Reference Tables point the user to these sources.

CONTRIBUTORS
       Chemicals commonly found at RCRA sites as identified by the Office of Solid Waste's
(OSW) Technical Assessment Branch are included in the HEAST.  The Office of Radiation
Programs has provided data on radionuclide carcinogenicity for Table 4.  Finally, the Office of
Air Quality Planning and Standards (OAQPS) has provided information on chemicals for which
Air Quality Criteria Documents and National Ambient Air Quality Standards have been
developed.

 CHEMICALS LISTED
       Most  of the chemicals included on the toxicity tables and carcinogenicity table are those
 for which at least one of the following EPA documents has been written: Health Effects Assess-
 ment Document (HEA), Health and Environmental Effects Profile (HEEP), Health and
 Environmental Effects Document (HEED), Health Assessment Document (HAD), Air Quality
 Criteria Document (AQCD), Drinking Water Criteria Document (DWCD). A description of each
 is provided in Appendix A, Section I. In a few cases, the values are supported by other written
 material, such as Work Group meeting notes or Carcinogen Assessment Group (CAG) Profiles.
 Radionuclide slope factor values are calculated by the EPA's Office of Radiation Programs.
        The names of criteria pollutants that are regulated as National Ambient Air Quality
 Standards (NAAQS) under the Clean Air Act are listed in the main body of the HEAST, but the
 actual criteria are included as Section V of Appendix A: Technical Information. The NAAQS
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 were not included in the tables in order to distinguish them from the reference concentration

 ([RfC]) values. The NAAQS and [RfCJs represent different levels of review and different

 methods of calculation and thus, must be interpreted and used differently.



 HIERARCHY OF SOURCES

       It is recognized that at any point in time there may be multiple old and new Agency

 documents or data bases that present different values on a specific chemical.  For chemicals

 other than those represented by the NAAQS or DWCDs, the following hierarchy of sources is

 recommended in evaluating chemical toxicity for Superfund sites:
       1.    The Agency's Integrated Risk Information System (IRIS) and cited
            references. Changes are made in this data base on a monthly basis, but
            there may be data gaps. Call RISK INFORMATION HOTLINE at
            (513)569-7254 for further information.

       2.    The Health Effects Assessment Summary Tables (HEAST) and cited
            references.

       3.    Consultation with the Superfund Health Risk Technical Support Center
            (TSC) at (513)569-7300.

       4.    Do not consult either the toxicity tables (Appendix A) in the Superfund
            Public Health Evaluation Manual (SPHEM, U.S. EPA, 1986) or the
            September 1988 Public Health Risk Evaluation Data Base (PHRED) as
            these sources are likely to contain numerous values that have since
            become out-of-date.
QUESTIONS

Chemical Toxicity and Carcinogenicity

       Regional EPA Superfund Staff may direct questions regarding the contents of the

chemical toxicity and carcinogenicity tables on the HEAST (e.g., chemicals not covered,

chemicals with pending [RfD]s) to EPA's Superfund Health Risk Technical Support Center
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(TSC) in Cincinnati, OH at (513)569-7300.  Questions from other users must be submitted to

the TSC in writing and must contain the following information:


      •   Superfund site name, site location and twelve-digit site number;

      •   Name and phone number of the site Remedial Project Manager (RPM) or
          Regional Risk Assessor/Toxicologist;

      •   Detailed description of the risk assessment related question.


      Please send requests via mail or FAX to:

        Superfund Health Risk Technical Support Center
        US EPA
        26 W. ML King Dr.
        National Center for Environmental Assessment
        MS 117
        Cincinnati, OH 45268
        FAX#: (513)569-7159


RCRA Chemicals

      Questions about RCRA chemicals may be addressed by calling the Office of Solid

Waste at (202)260-4761.

Radionuclide Carcinogenicity

      Questions concerning radionuclide carcinogenicity should first be addressed by

contacting the appropriate Regional Radiation Program Manager. A listing of these managers

and several contacts in the Office of Radiation Programs can be found in Exhibit 2 of the User's

Guide - Radionuclide Carcinogenicity.



REFERENCES

      Most cited Agency references (e.g., HEAs, HEEPs, HEEDs), are (or will soon be)

available through the National Technical Information Service (NTIS), 5285 Port Royal Road,
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 Springfield, VA 22161 [(703)487-4650].  Carcinogen Assessment Group (GAG) Profiles cited in

 Table 3 are available through the RCRA docket

 (202)260-9327.

       Drinking water documents are available by calling the Drinking Water Docket at

 (202)260-3027.



 ORDERING INFORMATION

       Limited copies of the HEAST are available for EPA Superfund staff, State Superfund

 programs and other Federal agencies working on Superfund sites, and EPA contractors

 working for the EPA Superfund program. Users in these groups can call Syracuse Research

 Corporation (202)479-0881 to be put on the mailing list.

       EPA's Office of Solid Waste (OSW) requests that their users (i.e., OSW staff,

 contractors, State solid waste programs) call the Health Assessment Section (202)260-4761 to

 obtain copies of the HEAST. Regional OSW staff are reminded that copies are sent to all EPA

 Regional libraries.

       Users of the HEAST in EPA's Office of Air and Radiation and State air programs should

 call Kelly Rimer of EPA's Office of Air Quality Planning and Standards at (919)541-2962.

       All other users must purchase the document from:

        National Technical Information Service (NTIS)
        5285 Port Royal Road
        Springfield, VA  22161
        (703)487-4650


       For ordering information, call the NTIS Subscriptions Department at (703)487-4630.

 NTIS normally ships 4th  class United States mail. When ordering the 1995 Health Effects

Assessment Summary Table annual update from NTIS refer to the following order number:

                   PB95-921199: FY95 Annual HEAST update
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STRUCTURE OF THE HEAST

      The HEAST Introduction contains explanatory material relative to the quality of

information on the HEAST, its sources, and its availability. This is followed by a listing of

changes since the last HEAST was published and then by User's Guides for both Chemical

Toxicity and Carcinogenicity, and Radionuclide Carcinogenicity.  The values on the HEAST are

presented in a series of five tables that contain toxicity information and three tables of

references. The information contained in each table and their designations are as follows:
      HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
      CARCINOGENICITY)
      Table 1 lists subchronic and chronic non-cancer toxicity values that were
      calculated using the current methodology practiced by the RfD/RfC Work Group.

      HEAST TABLE 1 REFERENCES: SUBCHRONIC AND CHRONIC TOXICITY (OTHER
      THAN CARCINOGENICITY)
      The references for Table 1 are numerically coded to associate each toxicity
      value clearly with its corresponding reference.
      HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC
      TOXICITY (OTHER THAN CARCINOGENICITY)
      Table 2 lists subchronic and chronic non-cancer toxicity values that are found in
      Agency documents, but were calculated by alternative methods that are not
      currently practiced by the RfD/RfC Work Group. These values are considered to
      be adequate provisional values for risk assessment purposes at Superfund and
      RCRA sites, but are subject to being reviewed by the RfD/RfC Work Group and
      revised when necessary to reflect current work group practices.

      HEAST TABLE 2 REFERENCES:  ALTERNATE METHODS - SUBCHRONIC AND
      CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
      The references for Table 2 are numerically coded to associate each toxicity
      value clearly with its corresponding reference.

      HEAST TABLE 3: CARCINOGENICITY
      Table 3 lists Carcinogenicity values that were calculated using the current
      methodology of the CRAVE Work Group.

      HEAST TABLE 3 REFERENCES:  CARCINOGENICITY
      The references for Table 3 are numerically coded to associate each toxicity
      value clearly with its corresponding reference.
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      HEAST TABLE 4: RADIONUCLIDE CARCINOGENICITY - SLOPE FACTORS
      (In Units of Picocuries)
      Table 4 lists ingestion, inhalation and external exposure carcinogenicity slope
      factors for radionuclides in units of picocuries and a factor to convert into the
      International System (SI) activity units of becquerels (Bq).
      Following the tables, a Technical Appendix (Appendix A) is available, containing the

following sections:


      I.   Data Sources and Selection Criteria Used in HEAST

      II.  Dose Conversions on HEAST

      III.  Chemical Name and Chemical Abstracts Service
            Registry Number Cross Reference

      IV.  Effect Level Definitions

      V.  National Ambient Air Quality Standards (NAAQS)
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                 WHAT'S NEW IN THE FY95 ANNUAL HEAST

GENERAL CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY

    The changes in this version of the HEAST reflect changes in IRIS through May 1,

1995. It is also current with RfD/RfC and CRAVE Work Group activities through May 1,

1995.
CHEMICAL-SPECIFIC CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY
A.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 1: SUBCHRONIC AND
    CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

Aroclor1254 011097-69-1
An indicator was added to show that the chronic oral RfD is now on IRIS.  The chronic
oral RfD is adopted as the subchronic oral [RfD].

Endosulfan  000115-29-7
An indicator was added to show that the chronic oral RfD is now on IRIS.

Mercuric Chloride 007487-94-7
This is a new entry to the table with a comment indicating that the chronic oral RfD was
adopted as the subchronic oral [RfD].

Mercury. Inorganic 007439-97-6
The HEAST entry is changed to Mercury. Elemental and a comment indicating that the
chronic [RfC] is under review.

Methvlmercurv 022967-92-6
A critical oral dose entry is indicated with a change in target and critical effect. The
subchronic [RfD] is also changed from 3E-4 to 1E-4. A comment is added to indicate
that a benchmark dose approach was used to derive the RfD.

Metribuzin 021087-64-9
The subchronic oral [RfD] was removed because the chronic oral RfD upon which it is
based in under review by the RfD/RfC Work Group.

Nickel (Metallic) 007440-02-0
The HEAST entry is changed to Nickel. Soluble Salts. "Various" is used for CAS
registry number since there is none for salts. A comment was added to indicate that
the chronic oral [RfD] was derived from the nickel moiety of the administered nickel
chloride salt.
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 B.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 2: ALTERNATE
     METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
     CARCINOGENICITY)

 Nitrobenzene 000098-95-3

 A typographical error was discovered in earlier issues of HEAST Table 2.  The
 subchronic [RfC] comment should read 6E-3 mg/kg/day, and  has been corrected
 accordingly.

 C.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3: CARCINOGENICITY

 Dichlorobenzene. 1.4-000106-46-7
 Carcinogenicity value in HEAST Table 3 is changed to reflect 1987 FR (July 8)
 52:25690-25717.

 Mercuric Chloride 007487-94-7
 An indicator was added to show that the EPA Group Classification is available on IRIS.

 Mercury. Elemental 007439-97-6
 An indicator was added to show that the EPA Group Classification is available on IRIS.

 Methvlmercury 0022967-92-6
 An indicator was added to show that the EPA Group Classification is available on IRIS.

 Nitrobenzene 000098-95-3
 The EPA Group Classification under review by the CRAVE Work Group was added to
 Table 3.

 D.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE: RADIONUCLIDE
    CARCINOGENICITY - SLOPE FACTORS

 CHEMICAL SPECIFIC CHANGES MADE IN THE JULY 1994 SUPPLEMENT NO.  1
 AND THE NOVEMBER 1994 SUPPLEMENT NO. 2 TO THE MARCH 1994 HEAST
 ANNUAL UPDATE

 The following changes were made in the July 1994 and November 1994 supplemental

 editions of the March 1994 HEAST Annual Update and represent changes that have

 occurred between the publication of the March 1994 HEAST Annual  Update and this

document, the May 1995 HEAST Annual Update. Because some HEAST users may

have been unaware of the publication of these supplements, the following information


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will indicate additional changes in toxicity information that should be noted. [Note:

These changes have been incorporated into the May 1995 Annual Update.]
A.  CHEMICAL-SPECIFIC CHANGES IN THE JULY 1994 AND NOVEMBER 1994
SUPPLEMENTS ON HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)

Acetone cvanohvdrin / (2-Methvllactonitrile) QQOQ75-86-5
The chronic oral [RfD] now under review by the RfD/RfC Work Group was added to
Table 1. The chronic oral [RfD] was modified to derive the subchronic oral [RfD]. The
synonym used by the RfD/RfC Work Group in its latest review is now included in
HEAST.

Acrolein 000107-02-8
The subchronic [RfD] and [RfC] Risk Assessment Issue Papers for this compound were
not reexamined by ECAO this year and the comment to contact the Superfund Health
Risk Technical Support Center was removed from HEAST.  No further change to the
table.

Acrvlic acid 000079-10-7
The chronic oral RfD has been replaced on IRIS.  The chronic oral RfD on IRIS was
adopted as the subchronic oral [RfD].

Anthracene 000120-12-7
A comment was added to indicate that the chronic inhalation [RfC] is considered not
verifiable (08/04/94) by the RfD/RfC Work Group.

Aroclor1248 012672-29-6
An indicator was added to show that a comment is now on  IRIS that the chronic oral
RfD is considered not verifiable by the RfD/RfC (07/20/93) Work Group.

Aroclor1254 012672-29-6
The chronic oral [RfD] under review by the RfD/RfC Work Group was added to the
table. The chronic oral [RfD] was modified to derive the subchronic oral [RfD].

Benzofatenthracene QQOQ56-55-3
A comment was added to indicate that the chronic inhalation [RfC]  is considered not
verifiable (08/04/94) by the RfD/RfC Work Group.
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J
Caprolactam  QQQ1Q5-60-2
An indicator was added to show that a comment is now on IRIS that the chronic
inhalation RfC is considered not verifiable (08/03/94) by the RfD/RfC Work Group.

Carbon disulfide 000075-15-Q
No change to the table.  Reference to the 1989 RfD/RfC Work Group was added.

Chlordane 000057-74-9
The subchronic [RfC] Risk Assessment Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST.  No further change to the table.

Dacthal 001861-32-1
The chronic oral RfD has been  replaced on IRIS. The chronic oral RfD on IRIS was
adopted as the subchronic oral [RfD].

Dibromoethane. 1.2- 000106-93-4
The subchronic inhalation [RfC] was modified to be consistent with the chronic
inhalation [RfC].

Dichlorobenzene. 1.2- 000095-50-1
The subchronic [RfD] Risk Assessment Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST.  No further change to the table.

Dichloroethane. 1.2- 000107-06-2
The subchronic [RfD] and [RfC] Risk Assessment Issue Papers for this compound were
not reexamined by NCEA this year.  The comment to contact the Superfund Health Risk
Technical Support  Center was the only  information on Table 1, therefore the compound
was removed from Table  1.

Dimethylphthalate  000131-11-3
The chronic oral [RfD] has been removed. A comment was added to show that the
chronic oral [RfD] is considered not verifiable by the RfD/RfC (02/16/94) Work Group.

Fluoranthene  000206-44-0
A comment was added to indicate that the chronic inhalation [RfC] is considered not
verifiable (08/04/93) by the RfD/RfC Work Group.

Hexachlorobenzene  000118-74-1
The subchronic [RfD] Risk Assessment  Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST. No further change to the table.
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Hexachlorobutadiene 000087-68-3
The subchronic [RfC] Risk Assessment Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST.  No further change to the table.

Methylenediphenvl isocyanate. 4.4- / (Diphenylmethanediisocyanate) 000101-68-8
An indicator was added to show that the chronic inhalation RfC is now on IRIS. The
chronic inhalation RfC on IRIS was adopted as the subchronic inhalation [RfC].

Nitric oxide 010102-43-9
The chronic oral RfD for this compound has been permanently withdrawn (09/01/94)
from IRIS.

Nitrogen dioxide  010102-44-0
The chronic oral RfD for this compound has been permanently withdrawn (09/01/94)
from IRIS. The subchronic oral [RfD] was removed from HEAST.

Phenanthrene 000085-01-8
A comment was added to indicate that the chronic  inhalation [RfC] is considered  not
verifiable (08/04/94) by the RfD/RfC Work Group.

Pyrene OOP 129-00-0
A comment was added to indicate that the chronic  inhalation [RfC] is considered  not
verifiable (08/04/94) by the RfD/RfC Work Group.

Styrene 000100-42-5
The subchronic [RfD] Risk Assessment Issue Paper for this compound was not
reexamined by NCEA this year and the comment to contact the Superfund Health Risk
Technical Support Center was removed from HEAST.  No further change to the table.

Trichloroethane. 1.1.1- QQQ071-55-6
A comment pertaining to  the subchronic [RfC] was added to the table.


B.  CHEMICAL-SPECIFIC CHANGES IN THE JULY 1994 AND NOVEMBER 1994
SUPPLEMENTS ON HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC
AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

    No changes were made to HEAST Table 2.
ft
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 C.  CHEMICAL-SPECIFIC CHANGES IN THE JULY 1994 AND NOVEMBER 1994
     SUPPLEMENTS ON HEAST TABLE 3: CARCINOGENICITY

 Bis(2-chloroisopropyh ether 039638-32-9
 Removed from Table 3. Compound tested was Technical bis(2-chloro-1-methylethyl)
 ether containing 70% bis(2-chloro-1-methylethyl) ether and 30% bis(2-
 chloroisopropyl) ether.  [Slope factor], [unit risk], and [EPA Group] classification were
 only derived for bis(2-chloro-1-methylethyl) ether.

 Bis(2-chloro-1 -methvlethyh  ether 000108-06-1
 Replaced on Table 3. Compound tested was Technical bis(2-chloro-1-methy(ethyl)
 ether containing 70% bis(2-chloro-1-methylethyl) ether and 30% bis(2-
 chloroisopropyl) ether.  [Slope factor], [unit risk], and [EPA Group] classification were
 only derived for bis(2-chloro-1-methylethyl) ether.

 Dimethvlhvdrazine. 1.2- 000540-73-8
 The general comment, "Contact the Superfund Health Risk Technical Support Center"
 has been removed from the table.

 Vinvl  chloride 000075-01-4
 No change in values. The General Comment was changed to reflect additional review
 by the CRAVE Work Group.

 D. CHEMICAL-SPECIFIC CHANGES IN THE JULY 1994 AND NOVEMBER 1994
 SUPPLEMENTS ON HEAST TABLE 4: RADIONUCLIDE CARCINOGENICITY -
 SLOPE FACTORS

    EPA's Office of Radiation and Indoor Air (ORIA) has recently revised its

 methodology for estimating radiogenic cancer risks and for deriving radionuclide slope

 factors1.  Specifically, ORIA  has:

 /  revised its  risk models for potential cancer sites based on current epidemiological
    data on radiogenic cancers in  humans and on recent recommendations of the
    National Academy of Sciences (NAS) Biological Effects of Ionizing Radiation
   1 Radionuclide ingestion and inhalation slope factors are central estimates in a linear model of the age-
averaged, lifetime attributable radiation cancer incidence (fatal and nonfatal cancer) risk per unit of activity
inhaled or ingested, expressed as risk per picocurie (pCi).  External exposure slope factors are central estimates
of lifetime attributable radiation cancer incidence risk for each year of exposure to external radiation from
photon-emitting radionuclides distributed uniformly in a thick layer of soU, and are expressed as risk/yr per
pCi/g soil.


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    (BEIR) Committee2, the International Commission on Radiological Protection
    (ICRP)3, and the U.S. Nuclear Regulatory Commission (NRC)4; (EPA's previous
    radiogenic cancer risk models were based primarily upon MAS BEIR III Committee
    recommendations.)

/   incorporated a dose and dose rate effectiveness factor (DDREF) of 2 for low-LET
    radiation for all cancer sites except breast (DDREF=1) whenever the total dose is
    below 20 rad (0.2 Gy) or the dose rate is below 10 mrad/min (0.1 mGy/min); (In
    EPA's previous methodology, a value of DDREF=1 was assumed for low-LET
    radiation for all cancer sites. For high-LET alpha radiation, EPA has retained the
    value of DDREF=1.)

/   revised the relative biological effectiveness (RBE) for alpha particles to RBE=20 for
    all cancer sites except breast (RBE=10) and leukemia (RBE=1); (In the previous
    methodology, EPA assumed a value of RBE=8 all cancer sites with the exception
    of leukemia (RBE=1.117).)

/   taken survival data and vital statistics from the U.S. Decennial Life Tables for
     1979-1981; (Previously, EPA used life table data for the 1970 decennial U.S.
    population  in the calculation of radionuclide slope factors.)

/    revised its method for integrating vital statistics and risk models for reference
     populations;

/    re-evaluated and revised (as appropriate) the radiation dose estimates used to
     derive the slope factors;

/    increased the Agency's estimate of the lifetime fatal cancer risk associated  with
     uniform, whole-body irradiation of the U.S. population from low-LET radiation at
     low doses and dose rates by approximately 24% from 392 to 509 per 106 person-
     rad (392 to 509 per 10" person-Gy); and

/    increased the Agency's cancer morbidity  risk estimate from 623 to 761 per  106
     person-rad (623 to 761 per 104 person-Gy).
    2 National Academy of Sciences (1990). Health Effects of Exposure to Low Levels of Ionizing Radiation.
BEIR V. Committee on the Biological Effects of Ionizing Radiations, National Research Council, Washington,
D.C.

    3 International Commission on Radiological Protection (1991), 1990 Recommendations of the International
Commission on Radiological Protection. ICRP Publication 60, Pergamon Press, New York, NY.

    4 U.S. Nuclear Regulatory Commission (1991, 1993), Health Effects Models for Nuclear Power Plant
Accident Consequence Analysis. NUREG/CR-4214. Addenda documenting the scientific basis for radiogenic
risk models published in 1991 (for low-LET radiation) and 1993 (for alpha radiation). See EPA 402-R-93-076
for discussion of these models.

                                        -16-

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     As a result of these changes in risk assessment methodology, assumptions, and



 calculations, ORIA has also rederived its lifetime excess cancer incidence slope factors



 for all radionuclides listed in previous HEAST updates and for a few new radionuclides



 added to this update. The HEAST User's Guide on Radionuclide Carcinogenicity



 provides an overview of ORIA's revised methodology for deriving radionuclide slope



 factors, and interested users are directed to Estimating Radiogenic Cancer Risks (EPA



 402-R-93-076) for a more detailed discussion of ORIA's approach and assumptions.








     For simplicity and to minimize the possibility of confusion and errors, this HEAST



 update includes a single table—Table 4—of radionuclide slope factors in customary



 activity units of picocuries (pCi) only, consistent with the reporting format for



 radionuclide slope factors in EPA's Integrated Risk Information  System (IRIS) data



 base.  Previous HEAST updates presented radionuclide slope factors in both



 customary units and the International System (SI) units of becquerels  (Bq) in Tables 4A



 and 4B, respectively.








     Similar to the former HEAST Tables 4A and 4B, the new Table 4  provides



 reference toxicity  information for each radionuclide, including a Chemical Abstract



 Service Reference Number (CASRN), radioactive half-life, lung  clearance classification



and gastrointestinal (Gl) absorption factor (where appropriate). It should be noted that



the Gl absorption  factors, lung classifications and radioactive half-lives are provided in



HEAST Table 4 for reference only and should not be used to correct, modify, or in any



way adjust radionuclide slope factors or intake assumptions in risk calculations.




                                     -17-

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    Inhalation, ingestion and external exposure slope factors for radionuclides marked

with the suffix "+D" in Table 4 include the added risks from associated radioactive

decay chain products with half-lives less than or equal to six months, assuming

equilibrium with the principal or parent radionuclide in the. environment. (Note that slope

factors for all radionuclides always account for associated decay products created

within the body after intake.)



    In summary, key features of this HEAST update for radionuclides are:

«a- All radionuclide ingestion, inhalation and external exposure cancer slope
   factors have been updated to incorporate EPA's revised methodology for
   estimating radiogenic cancer risk.

KT Table 4 presents radionuclide slope factors in customary activity units of
   picocuries (pCi) only, consistent with EPA's IRIS data base format for
   radionuclides.

us" Additional slope factors are now provided for the following six radionuclide
   decay chains:
   Ag-108m+D, Ce-144+D, Cm-243+D, Pu-241+D,  Pu-244+D, and Sb-125+D.
                                      -18-

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                     USER'S GUIDE: CHEMICAL TOXICITY








   The HEAST summarizes provisional toxicity and cancer values as well as values



developed for the NAAQS and DWCD chemicals. The provisional status of the toxicity



and cancer values is indicated by placing brackets around the title of the value. These



include provisional reference concentrations ([RfC]) and provisional reference doses



([RfD]) for toxicity from subchronic and chronic inhalation and oral exposure (Tables 1



and 2) and provisional slope factors ([slope factor]), provisional cancer classifications



([EPA Group]) and provisional unit risk values ([unit risk]) for carcinogenicity, based on



lifetime inhalation and oral exposure (Table 3).  Brackets should be included with the



acronym whenever a user quotes the value in an assessment document, and the



provisional nature of the value should be noted. A more complete discussion of how



Superfund develops and considers the toxicity assessment in hazardous waste sites is



presented in Chapter 7 of Risk Assessment Guidance for Superfund Volume 1: Human



Health Evaluation Manual, Part A, EPA/540/1-89/002.



   The references listed for each chemical in the Reference Tables for Tables 1, 2 and



3 represent the study or studies that are the basis for the [RfC], [RfD], [slope factor],



[EPA Group], or [unit risk], as well as the EPA reference that is the source of the



Agency analysis or risk assessment information. In  some cases, additional EPA



documents are also listed as a source of information on the chemical. Work Group



verified values found on IRIS are not found on the HEAST,  but are indicated in the



tables by the word "IRIS" in place of the number.
                                     -19-

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TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINO-
           GENICITY)
      The [RfC] or [RfD] is a provisional estimate (with uncertainty spanning perhaps

an order of magnitude) of the daily exposure to the human population (including

sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects

during a portion of the lifetime, in the case of a subchronic [RfC] or [RfD], or during a

lifetime, in the case of a chronic [RfC] or [RfD]. The [RfC] and [RfD] values are listed in

Tables 1 and 2 in columns with the headings "Subchronic" and "Chronic". The critical

dose or concentration level is usually a No-Observed-Adverse-Effect Level (NOAEL) or

a Lowest-Observed-Adverse-Effect Level (LOAEL) (See Appendix A, Section IV: Effect

Level Definitions, for more information).  The [RfC] or [RfD] is derived by dividing the

NOAEL or LOAEL by an uncertainty factor (UF) times a modifying factor (MF):


                        [RfC] or lRfD]=NOAEL °r LOAEL
                                         UF x MF


In Tables 1 and 2, the information  listed is the following:

Chemical                =  Chemical Name/CASRN
Level                   =  Effect Level
Dose                   =  Administered Dose or Concentration
Route                   =  Route of Administration
Species                 =  Tested Species
Experiment Length       =  Length of Exposure
Target                  =  Target Organ(s) Affected at Critical Level
Critical Effect            =  Effect(s) Observed at Critical Level
Subchronic [RfC]         =  Subchronic Inhalation [Reference  Concentration]
UF                     =  Uncertainty Factor for the Subchronic Inhalation
                           [Reference Concentration]
Subchronic [RfD]         =  Subchronic Oral [Reference Dose]
UF                     =  Uncertainty Factor for the Subchronic Oral [Reference
                           Dose]
Chronic [RfC]            =  Chronic Inhalation [Reference Concentration]


                                     -20-

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UF                     =   Uncertainty Factor for the Chronic Inhalation [Reference
                           Concentration]
Chronic [RfD]            =   Chronic Oral [Reference Dose]
UF                     =   Uncertainty Factor for the Chronic Oral [Reference
                           Dose]
Reference               =   Reference Identification Number for All Toxicity Values
                           on the Same Line.
An example of this information is shown in Figure 1, HEAST Table 1:

Chemical               =   GLYCIDALDEHYDE/000765-34-4
Level                  =   NOAEL
Dose                  =   10 PPM
Route                  =   INHALATION: INTERMITTENT
Species                =   RAT
Experiment Length       =   12 WEEKS
Target                 =   WHOLE BODY, BLOOD, KIDNEY
Critical Effect            =   DECREASED WEIGHT GAIN, HEMATOPOIETIC
                           EFFECTS
Subchronic [RfC]        =   1E-2 mg/cu.m
UF                     =   300
Subchronic [RfD]        =   4E-3 mg/kg/day
UF                     =   300
Chronic [RfC]            =   1E-3 mg/cu.m
UF                     =   3000
Chronic [RfD]            =   IRIS
UF                     =   IRIS
Reference              =   005968

Notice that a Chronic RfD for Glycidaldehyde is available on IRIS, so it is not listed
here. Also notice that there are footnotes for this chemical that indicate a route-to-route
extrapolation was performed and that there is information available on Table 3:
Carcinogenicity.
      Also given in Figure 1 is an example of the References for Table 1 for the same

chemical. The reference is identified by the chemical name (Glycidaldehyde), the

CASRN (00765-34-4), and the reference number that links it with the toxicity values

(005968).
                                   -21-

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                                                                    FIGURE  1
                                      Example  Data  and  References  for Chemical  Toxicity
CHEMICAL
LEVEL     ROUTE
                         HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN  CARCINOGEN I CITY)        January 1992
SEECJES
EXPERIMENT LENGTH TARGET
    CRITICAL EFFECT
       Subchronic            Chronic
   [RfC]       [RfD]     [RfC]      [RfD]      REFERENCE
   (mq/cu in) (ma/kg/dav) InaZcu ml  (mo/kq/dav)
UF         UF       UF        UF
GLYCIDALDEHYDE
NOAEL    10 PPM
        INHALATION:
        INTERMITTENT
  000765-34-4
 RAT
 12 WEEKS   WHOLE BODY
           BLOOD
           KIDNEY
                     1E-2
     4E-3
                                        1E-3
                          IRIS
                                                             005968
DECREASED WEIGHT GAIN
HEMATOPOIETIC EFFECTS
EFFECTS
300
                                   300
                   3000
        SUBCHRONIC [RfD]  COMMENT-  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION  FACTOR OF 0.5.
        CHRONIC [RfD] COMMENT-  BASED ON ROUTE TO ROUTE EXTRAPOLAriON USING AN ABSORPTION FACTOR OF 0.5.
    ,    GENERAL COMMENT:  ALSO SEE TABLE 3: CARCINOGENICITY.
    Ni
    TO
                                   REFERENCES FOR  HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                         (OTHER  THAN CARCINOGENICITY)
                                                                                                            January 1992
                   CH. RJ
               2:  23-30.
                                          R LIMA AND GS LOQUVAM. 1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH ENVIRON HEALTH.
               US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE : OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT. National  Center for Environmental Assessment.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE.  WASHINGTON. DC.

-------
      The uncertainty factor used in calculating the [RfC] or [RfD] reflects scientific



judgment regarding the various types of data used to estimate [RfC] or [RfD] values.



An uncertainty factor of 10 is usually used to account for variation in human sensitivity



among populations. An additional 10-fold factor is usually used to account for each of



the uncertainties assumed when extrapolating from animal data to humans, when



extrapolating from a LOAEL to a NOAEL, and when extrapolating from subchronic to



chronic exposure.  In order to reflect professional assessment of the uncertainties of the



study and the data base not explicitly addressed by the above uncertainty factors (e.g.,



completeness of the overall data base), an additional uncertainty factor or modifying



factor ranging from greater than 0 to less than or equal to 10 is applied.  The default



value for this modifying factor is 1.



      For chemicals for which a chronic [RfC] or [RfD] is presented in Tables 1 and 2,



a subchronic [RfC] or [RfD] is usually derived, if not previously derived in the Agency



documents that originally addressed the chemical.  Subchronic toxicity values are not



evaluated by the RfD/RfC Work Group.  The subchronic [RfC] or [RfD] is derived in



either of two ways: 1)  If an uncertainty factor was used to account for extrapolation



from subchronic to chronic exposure in the derivation of the chronic [RfC] or [RfD], then,



the subchronic [RfC] or [RfD] is derived from the same benchmark concentration or



dose without applying the uncertainty factor for subchronic to chronic exposure extrapo-



lation.  2) If the chronic [RfC] or [RfD] was derived without use of an uncertainty factor



for extrapolating from subchronic to chronic exposure (e.g., if chronic data were



available), then, the chronic [RfC] or [RfD] is adopted as the subchronic [RfC] or [RfD].
                                      -23-

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      Tables 1 and 2 list the uncertainty factor and modifying factor, multiplied



together, to form a single factor under the heading "Uncertainty Factor."  For example,



the uncertainty factor of 3000 listed for the chronic inhalation [RfC] for Glycidaldehyde



reflects an uncertainty factor of 1000 (10 for human sensitivity, 10 for extrapolation from



animal to human, and 10 for extrapolation from subchronic to chronic) and a modifying



factor of 3 (for an inadequate data base); the uncertainty factor of 500 listed for the



subchronic oral [RfD] for cyanide reflects an uncertainty factor  of 100 (10 for human



sensitivity, and 10 for extrapolation from animal to human) and a modifying factor of 5



(to account for tolerance to cyanide when ingested by food rather than administration



by gavage or by drinking water).



      [RfC] and [RfD] values are specific for the route of exposure for which they are



listed on Tables 1 and 2.  In the few instances where an [RfD]  or [RfC] has been



determined from another exposure route, route-to-route extrapolation is indicated by a




footnote.



      The current methodology for the derivation of inhalation RfCs is detailed in the



document, "Interim Methods for Development of Inhalation Reference Doses" (U.S.



EPA, 1990,  EPA/600/8-88/066F, NTIS PB90-145723).  These  methods are different



from those used for oral RfDs because of (1) the dynamics of the respiratory system



and its diversity across species, and (2) differences in the physicochemical properties of



contaminants  (such as the size and shape of a particle or whether the contaminant is



an aerosol or a gas). Parameters such as deposition, clearance mechanisms and the



physicochemical properties of the inhaled agent are considered in the determination of



the effective dose delivered to the target organ.




                                      -24-

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      An RfC value calculated using this interim methodology is generally reported as


a concentration in air (mg/m3), although it may be converted to a corresponding inhaled


dose (mg/kg/day) by dividing by 70 kg (an assumed human body weight), multiplying by


20 m3/day (an assumed human inhalation rate), and adjusting by an appropriate


absorption factor. This conversion, however, may often be technically incorrect, and


the appropriateness of doing this must be evaluated on a case-by-case basis. It is


recommended that HEAST users that plan to use this technique read a further


discussion of the difficulties inherent in this dose conversion that can be found in


Appendix A, Section II: Dose Conversions On HEAST.


      Inhalation [RfC] values reported in HEAs and early HEEDs that were finalized


pfior to the implementation of the interim methods were calculated using methods


similar in concept to those used for oral [RfDJs. These values are reported both as a


concentration in air (in mg/m3 for continuous, 24 hours/day exposure) under the column


[RfC], and as a corresponding inhaled dose (in mg/kg/day) in the footnotes called,


Chronic (Subchronic) [RfC] Comment.  These chemicals are listed in Table 2: Alternate


Methods - Subchronic and Chronic Toxicity (Other Than Carcinogenicity).


      [RfD] values for oral exposure are reported as mg/kg/day. An oral [RfD] value


can be converted to a corresponding concentration in drinking water, assuming human


body weight of 70 kg and water consumption of 2 L/day, as follows:



                     ..  .    .     oral [RfD] (in  mg/kg/day) x 70 kg
                  mglL in water = 	'	—	^—-——	-
                                            2 L/day



      The [RfC] or [RfD] is used as a reference point for gauging the potential effects


of other exposures.  Usually, exposures that are less than the [RfC] or [RfD] are not



                                      -25-

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likely to be associated with health risks. As the frequency of exposures exceeding the

[RfC] or [RfD] increases and as the size of the excess increases, the probability

increases that adverse health effects may be observed in a human population.

Nonetheless, a clear distinction that would categorize all  exposures below the [RfC] or

[RfD] as "acceptable" (risk-free) and all exposures in excess of the [RfC] or [RfD] as

"unacceptable" (causing adverse effects) cannot be made. In addition, [RfC] and [RfD]

values, and particularly those with limitations in the quality or quantity of supporting

data, are subject to change as additional information becomes available.

      When [RfC] or [RfD] values are listed  in Tables 1 or 2 for chemicals that are

carcinogens, a footnote will refer to Table 3 if additional information concerning

carcinogenicity is available in that table. [RfC] and [RfD]  values that have been derived

for carcinogens are based on noncancer endpoints only and should not be assumed to

be protective against carcinogenicity.


TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
           (OTHER THAN CARCINOGENICITY)

      Chemicals are listed in Table 2 when the [RfD] or [RfC] was derived from

alternative methods that are not currently practiced by the RfD/RfC Work Group. The

table consists primarily of inhalation [RfC] values determined from methodology that

does not follow the interim inhalation methods adopted by the Agency, and [RfC] or

[RfD] values based on route-to-route extrapolation with inadequate pharmacokinetic

and toxicity data. A footnote is added to each chemical to provide a short explanation

of the specific methodology used in calculating these provisional toxicity values.  Most

of these toxicity values were formerly listed in Table 1. In some instances, the chemical


                                     -26-

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 may be listed in both Tables 1 and 2 if the chemical has more than one toxictty value.

 Table 2 follows the same format as Table 1 (refer to Figure 1).



 TABLES:  CARCINOGENICITY

      In assessing the carcinogenic potential of a chemical, the Human Health

 Assessment Group (HHAG) of EPA classifies the chemical into one of the following

 groups, according to the weight of evidence from epidemiologic and animal studies:
     Group A -    Human Carcinogen (sufficient evidence of carcino-
                 genicity in humans)

     Group B -    Probable Human Carcinogen (B1 - limited evidence of
                 carcinogenicity in humans; B2 - sufficient evidence of
                 carcinogenicity in animals with inadequate or lack of
                 evidence in humans)

     Group C -    Possible Human Carcinogen (limited evidence of
                 carcinogenicity in animals and inadequate or lack of
                 human data)

     Group D -    Not Classifiable as to Human Carcinogenicity
                 (inadequate or no evidence)

     Group E -    Evidence of Noncarcinogenicity for Humans (no
                 evidence of carcinogenicity in adequate studies).
These classifications are shown under [EPA Group] on Table 3.

    Quantitative carcinogenic risk assessments are performed for chemicals in Groups

A and B, and on a case-by-case basis for chemicals in Group C.  Cancer [slope factors]

(formerly called cancer potency factors in the Superfund Public Health Evaluation

Manual) are estimated through the use of mathematical extrapolation models, most

commonly the linearized multistage model, for estimating the largest possible linear


                                    -27-

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slope (within the 95% confidence limit) at low extrapolated doses that is consistent with

the data. The [slope factor] or risk is characterized as an upper-bound estimate, i.e.,

the true risk to humans, while not identifiable, is not likely to exceed the upper-bound

estimate and in fact may be lower.

     Quantitative carcinogenic estimates listed in Table 3 include the following:

     [slope factor] = risk per unit dose = risk per mg/kg/day

     [unit risk] for inhalation exposure = risk per concentration unit in air
     = risk per ug/m3

     [unit risk] for oral exposure = risk per concentration unit in water =
     risk per ug/L


[Unit risk] estimates for inhalation and oral exposure can be calculated by dividing the

appropriate [slope factor] by 70 kg and multiplying by the inhalation rate (20 m3/day) or

the water consumption rate (2 L/day), respectively, for risk associated with unit

concentration in air or water.  Hence,

risk per ug/m3 (air) = (risk per mg/kg/day) x  1  x20 m3/dayx 103 (mg/ug)
                                       70kg

risk per ug/L (water) = (risk per mg/kg/day) x 1  x2 L/day x 10'3 (mg/ug)
                                         70kg


Quantitative estimates of carcinogenic risk are listed under [Unit Risk] or [Slope Factor]

in Table 3. Information on the study and data set used for estimation of the [slope

factor] is given  in the other columns of Table 3.

     In Table 3, the information listed is the following:

Chemical                        =  Chemical  Name/CASRN
Route                           =  Route of Administration
Species                         =  Tested Species


                                       -28-

-------
 Experiment Length               = Length of Exposure
 Target                          = Target Organ(s) Affected at Critical Level
 Cancer                         = Tumors Observed at Critical Level (Not
                                  Specified if More Than One Type of Tumor)
 [EPA Group]                     = EPA Classification by Weight of Evidence
 Oral [Slope Factor]               = Risk Per Unit Dose
 Inhalation [Slope Factor]          = Risk Per Unit Dose
 Oral [Unit Risk]                   = Risk Per Concentration Unit in Water
 Inhalation [Unit Risk]              = Risk Per Concentration Unit in Air
 Reference                      = Reference Identification Number for All Toxicity
                                  Values on the Same Line.
An example of this information is shown in Figure 2, HEAST Table 3:

Chemical                        =  DIMETHYLHYDRAZINE, 1,2-7000077-78-1
Route                          =  ORAL: DRINKING WATER
Species                         =  MOUSE
Experiment Length                =  LIFETIME
Target                          =  CARDIOVASCULAR SYSTEM
Cancer                         =  TUMORS
[EPA Group]                     =  B2
Oral [Slope Factor]                =  3.7E+1 (MG/KG/DAY)-1
Inhalation [Slope Factor]           =  3.7E+1 (MG/KG/DAY)-1
Oral [Unit Risk]                   =  1.1E-3 (UG/L)-1
Inhalation [Unit Risk]              =  1.1E-2 (UG/CU M)-1
Reference                       =  009993

Notice that the inhalation values for 1,2-Dimethylhydrazine was extrapolated from the
oral data.
    Also given in Figure 2 is an example of the References for Table 3 for the same

chemical.  The reference is identified by the chemical name (Dimethylhydrazine, 1,2-),

the CASRN (000077-78-1), and the reference number that links it with the toxicity

values (009993).

    Quantitative carcinogenic estimates are specific for the route of exposure for which

they are listed on Table 3.  Footnotes are used to indicate those instances in which the

values for inhalation or oral exposure are based on extrapolation from another route of

                                    -29-

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                                                                        FIGURE  2
                                               Example  Data  and References  for  Carcinogenicity
                                                         HEAST TABLE  3:  CARCINOGENICITY
                  EXPERIMEHT LENGTH
CHEMICAL ROUTE          SPECIES     TARGET               CANCER
DIMETHYLHYDRAZINE.1,2-      000077-78-1
        ORAL: DRINKING  LIFETIME
        WATER
                       MOUSE      CARDIOVASCULAR       TUMORS
                                  SYSTEM
        Inhalation [Slope] Conment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            [SLOPE FACTOR]
  [EPA     ORAL     INHALATION
GROUP]  (rag/kg/day)'(mg/kg/day)'
  B2
3.7E+1
3.7E+1
                                                                    January 1992
                         [UNIT RISK]
                        ORAL  INHALATION   REFERENCE
                        (ug/L) •' (ug/cu m)l
1.1E-3
LIE-2  009993
                                               REFERENCES FOR  HEAST TABLE 3:   CARCINOGENICITY
                                                                    January  1992
DIMETHYLHYDRAZINE,  1.2-                 000077-78-1
        009993 TOTH B AND  K PATEL.  1982. CARCINOGENICITY DOSE-RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF  1.2-DIMETHYLHYDRAZINE
               DI-HYDROCHLORIDE IN  MICE. I  LIGHT AND TRANSMISSION ELECTRON MICROSCOPIC STUDY OF COLONOIC NEOPLASMS.  AM. J. OF PATH.
               84:69-86.

               US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE)  WORK GROUP.
         IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254.  FTS 684-7254.

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exposure.  The route-to-route conversion required to present inhalation [slope factors]

in the units of mg/kg/day is considered by the CRAVE Work Group to be technically

incorrect. It is recommended that HEAST users who plan to use this information read a

further discussion of the difficulties inherent in this dose conversion which can be found

in Appendix A, Section II: Dose Conversions On HEAST.

    To estimate risk-specific concentrations in air from the [unit risk] in  air as presented

in Table 3, the specified level of risk is divided by the [unit risk] for air.  Hence, the air

concentration (in ug/m3) corresponding to an upper-bound increased lifetime cancer risk

of 1x10'5 is calculated as follows:
                        pg/m3 in air =
                                      [unit risk] in

    To estimate risk-specific concentrations in drinking water from the oral [slope factor]

values presented in Table 3, the specified level of risk is multiplied by 70 kg and divided

by the [slope factor] times 2 L/day.  Hence, the water concentration corresponding to an

upper-bound increased lifetime cancer risk of 1x10'5 is calculated as follows:
               mg/L in water = _ ^W  x 70 kg _
                              [slope factor] in (mglkglday)'^ x 2 L/day
                                      -31-

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          USER'S GUIDE:  RADIONUCLIDE CARCINOGENICITY



Introduction

    EPA classifies all radionuclides as Group A carcinogens. HEAST Table 4 lists

ingestion, inhalation and external exposure cancer slope factors for radionuclides in

units of picocuries (pCi).5 Ingestion and inhalation slope factors are central estimates in

a linear model of the age-averaged, lifetime attributable radiation cancer incidence

(fatal and nonfatal cancer) risk per unit of activity inhaled or ingested, expressed as

risk/pCi. External exposure slope factors are central estimates of lifetime attributable

radiation cancer incidence risk for each year of exposure to external radiation from

photon-emitting radionuclides distributed uniformly in a thick layer of soil, and are

expressed as risk/yr per pCi/gram soil. When combined with site-specific media

concentration data and appropriate exposure assumptions6, slope factors can be used

to estimate lifetime cancer risks to members of the general population due to

radionuclide exposures.
   5 Slope factors are reported in Table 4 in the customary units of picocuries (1 pCi - 10~12 curies (Ci) -
3.7xlO"2 nuclear transformations per second) for consistency with the system used for radionuclides in the IRIS
database. If required, slope factors hi Table 4 can be converted into the International System (SI) units of
becquerels (1 Bq = 1 nuclear transformation per second) by dividing each inhalation, ingestion, or external
exposure value by 27.03. Users can calculate cancer risks using slope factors expressed in either customary units
or SI units with equivalent results, provided that they also use air, water and soil concentration values in the
same system of units.

   6 Agency standardized default exposure scenarios and assumptions for use in baseline risk assessment
are provided in EPA (1991), Risk Assessment Guidance for Superfund, Vol. I,  Human Health Evaluation
Manual, Supplemental Guidance: "Standard Default Exposure Factors" (Interim Final),  Office of Emergency and
Remedial Response, OSWER Directive 9285.6-03. [NTIS order number:  PB 91-921314.]

                                          -32-

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 Intended Users and Applications

    HEAST users include individuals from the EPA, other Federal agencies, States and

 contractors who are responsible for the identification, characterization and remediation

 of sites contaminated with radioactive materials.  Radionuclide slope factors are

 calculated by EPA's Office of Radiation and Indoor Air (ORIA) to assist HEAST users

 with risk-related evaluations and decision-making at various stages of the remediation

 process.  During site assessment, for example, slope factors are used in EPA's Hazard

 Ranking  System (HRS) to assign toxicity factor values to radionuclides to calculate site

 scores. During the remedial investigation and feasibility study (RI/FS), slope factors are

 used to determine baseline site risk, to develop preliminary remediation goals, and to

 evaluate cleanup alternatives. For further examples on the application of radionuclide

 slope factors in risk evaluations, users are referred  to the following EPA documents:
      •     Hazard Ranking System (HRS), Federal Register (55 FR 515320),
            December 1990.

      •     Risk Assessment Guidance for Superfund; Volume I - Human Health
            Evaluation Manual (RAGS/HHEM), Part A, Baseline Risk Assessment
            (EPA/540/1-89/002).

      •     RAGS/HHEM Part B, Development of Risk-Based  Preliminary
            Remediation Goals (OSWER Directive 9285.7-01 B).  [NTIS order number:
            PB 92-963333.]

      •     RAGS/HHEM Part C, Risk Evaluation of Remedial Alternatives (OSWER
            Directive 9285.7-01 C). [NTIS order number: PB 92-963334.]


      Copies of RAGS/HHEM Parts A, B and C are available to the public from the

National Technical Information Service (NTIS) at (703) 487-4650.  Copies are  available

to EPA staff by calling the Superfund Documents Center at (703) 603-8917.
                                     -33-

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Radiation Effects
      Ionizing radiation has been shown to be a carcinogen, a mutagen, and a
teratogen.  Radiation can induce cancers in nearly any tissue or organ in both humans
and animals, and the probability of cancer induction increases with increasing radiation
dose. Cancer induction is a delayed response that has been documented extensively
in epidemiological studies of Japanese atomic bomb survivors, underground uranium
miners, radium dial painters, and patients subject to a variety of  radiation treatments.
Laboratory animal research and mammalian tissue culture studies have provided
additional, collaborative data.

      Mutagenic effects of radiation have been demonstrated primarily in animal and
tissue culture studies; limited data from studies of A-bomb survivors indicate that
humans may be as sensitive or less sensitive than animals to radiogenic mutagenicity.
Data are also available from both human and animal studies on the teratogenic effects
of radiation. These data show that the fetus is most sensitive to radiation injury during
the early stages of organ development (between 8 and 15 weeks for the human fetus).
Resultant radiation-induced malformations depend on which cells are most actively
differentiating at the time of exposure.

      EPA classifies all radionuclides  as Group A carcinogens, based on their property
of emitting ionizing radiation and on the extensive weight of evidence provided by
epidemiological studies of radiogenic cancers in humans. At Superfund radiation sites,
EPA generally evaluates potential human health risks based on the radiotoxicity, i.e.,
adverse health effects caused by ionizing radiation, rather than on the  chemical toxicity,
of each radionuclide present.  These evaluations consider the carcinogenic effects of
radionuclides only.  In most cases, cancer risks are limiting, exceeding both mutagenic
and teratogenic risks.
                                       -34-

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  Derivation of Radionuclide Slope Factors
        EPA's Office of Radiation and Indoor Air (ORIA) calculates radionuclide slope
  factor values using health effects data and dose and risk models from a number of
  national and international scientific advisory commissions and organizations, including
  the National Academy of Sciences (NAS), the National Council on Radiation Protection
  and Measurements (NCRP), the United Nations Scientific Committee on the Effects of
 Atomic Radiation (UNSCEAR), and the International Commission on Radiological
  Protection (ICRP).  A detailed discussion of ORIA's approach and assumptions is
 provided in Estimating Radiogenic Cancer Risks (EPA 402-R-93-076).

        Radionuclide slope factors are calculated for each radionuclide individually,
 based on its unique chemical, metabolic and radioactive properties. The calculation
 uses dose estimates from EPA's computer code RADRISK7, vital statistics from the
 L/.S. Decennial Life Tables for 1979-1981 (described in EPA 402-R-93-076), and
 cancer risk estimates based largely on the results of the NAS BEIR V report8, ICRP
 Publication 609, and U.S. Nuclear Regulatory Commission (NRC) analyses.10 Ingestion
 and inhalation slope factors for radionuclides account for:

       •     the amount of radionuclide transported into the bloodstream  from  either
              the gastrointestinal  (Gl) tract following ingestion, or from the  lungs
              following inhalation;
       •     the ingrowth and decay of radioactive progeny produced
              within the body subsequent to intake;
   7 Dunning, D.E. Jr., Leggett, R.W., and Yalcinatas, M.G. (1980). "A Combined Methodology for Estimating
Dose Rates and Health Effects from Exposure to Radioactive Pollutants," ORNL/TM-7105.
BFTR vatrDal A«ademy ,? Rd?CeS V???' Health Effects of Exposure to I,ow levels of
PfelK v» Committee on the Biological Effects of Ionizing Radiations, National Research Council, Washington,

   'International Commission on Radiological Protection (1991), 1990 Recommendations of the
Commission on Radiological Protection. ICRP Publication 60, Pergamon Press, New York, NY.
   m U.S^ Nuclear Regulatory Commission (1991, 1993), Health Effects Models for Nuclear Power Plant
Accent Consequence Analysis, NUREG/CR-4214.  Addenda documenting the scientific basis for radiogenic
risk models published in 1991 (for low-LET radiation) and 1993 (for alpha radiation).  See EPA 402-R-93-076
for discussion of these models.

                                        -35-

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      •      the distribution and retention of each radionuclide (and its associated
             progeny, if appropriate) in body tissues and organs;
      •      the radiation dose delivered to body tissues and organs from the
             radionuclide (and its associated progeny, if appropriate); and
      •      the sex, age, and organ-specific risk factors over the lifetime of exposure.

      The slope factors are the average risk per unit intake or exposure for an
individual in a stationary population with vital statistics (mortality rates) of the United
States in 1980. (The expected lifetime for an individual in this population is about 74
years.)  Consequently, radionuclide ingestion and inhalation slope factors are DQJ
expressed as a function of body weight and time, and do QOJ require corrections for Gl
absorption or lung transfer efficiencies.
  NOTE:  The GI absorption values (fj, ICEP lung classifications (D, W, Y) and radioactive half-
  Uves are provided in HEAST Table 4 for reference only and should not be used to correct,
  modify, or in any way adjust radionuclide slope factors or intake assumptions in risk calculations.
       External slope factors provide cancer risk estimates per unit exposure to a
uniform radionuclide concentration in soil.  These factors, which account for photon
energy flux attenuation and buildup in soil, are calculated for each radionuclide using
volume and surface dose factors derived using the computer code DFSOIL11

       Because of the radiation risk models employed for both internal and external
exposures, slope factors for radionuclides  are characterized as central estimates in a
linear model of the age-averaged lifetime total radiation cancer incidence risk per unit
intake or exposure.
    11 Sjoreen, A.L., Kocher, D.C., Kfflough, G.G. and Miller C.W. (1984). "MLSOIL and DFSOIL - Computer
Codes to Estimate Effective Ground Surface Concentrations for Dose Computations," Oak Ridge National
Laboratory, Oak Ridge, TN, ORNL-5974.
                                        -36-

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 About the Information Provided in Table 4
       Table 4 lists ingestion, inhalation and external exposure slope factors of principal
 radionuclides, and provides key parameter values used in the derivation of slope factor
 values. Radionuclides are presented alphabetically by element and atomic weight.

       Selected  radionuclides and radioactive decay chain products are designated in
 HEAST Table 4 with the suffix "+D" (e.g., U-238+D,  Ra-226+D, Cs-137+D) to indicate
 that cancer risk estimates for these radionuclides include the contributions from their
 short-lived decay products, assuming equal activity concentrations (i.e., secular
 equilibrium) with the principal or parent nuclide in the environment.12  Decay chains are
 identified  in Exhibit 1.

       In most cases, site-specific analytical data should be used to establish the actual
 degree of equilibrium between each parent radionuclide and its decay products in each
 media sampled. However, in the  absence of empirical data, the "+D" values for
 radionuclides should be used unless  there are compelling reasons not to.  For example,
 the external slope factors for Cs-137  and  Cs-137+D are 0.0 and 2x10"6 (risk per year
 per pCi/gram), respectively. The value for Cs-137+D is higher because it includes the
 risk contribution from cesium's short-lived gamma-emitting decay product Ba-137m
 (half-life, 25.5 minutes) which, under  most environmental conditions, will be in secular
 equilibrium with Cs-137.

       Note that there may be circumstances, such as long disposal times or
 technologically enhanced concentrations of naturally occurring radionuclides, that may
 necessitate the combination of the risks of a parent radionuclide and its decay products
 over several contiguous subchains. For example, Ra-226 soil analyses at a site might
 show that all radium decay products are present in secular equilibrium down to stable
 Pb-206 (See Exhibit 1). In this case, Ra-226 risk calculations should be based on the
   12 There is one exception to the assumption of secular equilibrium. For the inhalation slope factor for Rn-
222+D reported in HEAST Table 4, ORIA assumes a 50% equilibrium value for radon decay products (Po-218,
Pb-214, Bi-214 and Po-214) in air.

                                       -37-

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ingestion, inhalation and external exposure slope factors for the Ra-226+D subchain,
plus the ingestion, inhalation and external exposure factors for the Pb-210+D subchain.
For actual sites, users should consult with a health physicist or  radiochemist (1) to
evaluate the site-specific analytical data to determine the degree of equilibrium between
parent radionuclides and decay members of contiguous decay chains and (2) to assist
in the combination of appropriate slope factor values.  For health physics and
radioanalytical support,  HEAST users may contact EPA's Regional Radiation Program
Managers, ORIA's National Air and Radiation Laboratory (NAREL) in Montgomery,
Alabama, ORIA's Las Vegas Laboratory (ORIA-LV) in Las Vegas, Nevada, or the ORIA
contact at EPA headquarters in Washington, D.C., listed in Exhibit 2.

      A Chemical Abstract System Reference Number (CASRN) is assigned to each
radionuclide for identification and reporting accuracy during risk assessments, and
radioactive half-lives are provided for reference.

      The designations "D", "W", and "Y" presented in Table 4 under the heading
"ICRP Lung  Class" in the tables refer to the lung clearance times for inhaled particulate
radionuclides, expressed as days (D), weeks (W), or years (Y), as recommended by the
International Commission on  Radiological Protection (ICRP). Gaseous radionuclides,
e.g., Rn-222, are designated  with an asterisk ("*"). "Gl Absorption Factors, f/' are the
fractional amounts of each radionuclide that may be absorbed from the gastrointestinal
(Gl) tract into blood following an oral intake. The ICRP lung clearance classifications
and Gl absorption factors provided in Table 4 are the default values that EPA used to
calculate radionuclide slope factors for inhalation and ingestion exposures, respectively.
These factors are provided for reference only (see the Note Box).

Where to Address Questions About Radionuclide Slope Factors:
      EPA continuously reviews the scientific literature on radiation effects to ensure
that the Agency's risk assessment methodologies are consistent with current models
                                      -38-

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and assumptions. As risk methodologies are refined, EPA will revise and update the
slope factors in Table 4.

      HEAST users with questions about radionuclide slope factor values and their use
in radiation risk assessments should contact Michael Boyd of the Remedial Guidance
Section of the Radiation Assessment Branch of ORIA at (202) 233-9395. Written
requests for assistance can be sent by fax to (202) 233-9650.
                                    -39-

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Exhibit 1.  Radionuclide Decay Chains Considered Explicitly in HEAST Table 4*
Principal Radionuclide*
Nuclide
Ac-227+D
Ag-108m+D
Ag-llOm+D
Am-243+D
Ce-144+D
Cs-137+D
Np-237+D
Pb-210+D
Pu-241+D
Pu-244+D
Ra-226+D
Ra-228+D
Ru-106+D
Sb-125+D
Sr-90+D
Half-life
(yr)
22
127
0.7
7.4 x 103
0.8
30
2.1 x 10*
22
14
8.3 x 107
1.6 x 103
8
1
3
29
Associated Decay Chain*
[Th-227 (98.6%, 19 d)]
Fr-223 (1.4%, 22 min)
Ra-223 (11 d)
Rn-219 (4 s)
Pc-215 (2 ms)
Pb-211 (36 min)
Bi-211 (2 min)
[Tl-207 (99.7%, 5 min)
Po-211 (0.3%, 0.5s)]
_d
Ag-108 (9%, 2 min)
Ag-1 10(1%, 25s)
Np-239 (2 d)
[Pr-144 (9%, 17 min)
Pr-144m (2%, 7 min)]
Ba-137m (95%, 3 min)
Pa-233 (27 d)
Bi-210 (5 d)
Po-210 (138 d)
[Am-241 (~100%, 432 y)
U-237 (7 d)]e
U-240 (~100%, 14 h)
Np-240
Rn-222 (4 d)
Po-218 (3 min)
Pb-214 ("100%, 27 min)
Bi-214 (20 min)
Po-214 (~100%, 1 min)
Ac-228 (6 h)
Rh-106 (30 s)
Te-125m (23%, 58 d)
Y-90 (64 h)
Terminal Nuclide or
Radionuclide0
Nuclide
Pb-207
Pd-108 (91%)
[Cd-108 (98%)
Pd-108 (2%)]
Cd-110(99%)
[Cd- 110 (99.7%)
Pd- 110 (0.3%)
Pu-239
Nd-144
Ba-137
U-233
Pb-206
Np-237
Pu-240
Pb-210
Th-228
Pd-106
Te-125
Zr-90
Half-life
(yr)
*
*
*
*
*
*
*
2.4 x 104
*
*
' 1.6 x 105
*
2.1 x 106
6.5 x 103
22
2
*
*
*
                                  -40-

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                                     Exhibit  1  (Continued)
Principal Radionuclide"
Nuclide
Th-228+D
Th-229+D
U-235+D
U-238+D
Half-life
(yr)
2
7.3 x 103
7.0 x 108
4.5 x 109
Associated Decay Chaink
Ra-224 (4 d)
Rn-220 (56 s)
Po-216 (0.2 s)
Pb-212 11 h)
Bi-212 (61 min)
[Po-212 (64%, 0.3 us)
Tl-208 (36%, 3 min)]
Ra-225 (15 d)
Ac-225 (10 d)
Fr-221 (5 min)
At-217(32ms)
Bi-213 (46 min)
[Po-213 (98%, 4 MS)
Tl-209 (2%, 2 min)]
Pd-209 (3 h)
Th-231 (26 h)
Th-234 (24 d)
[Pa-234m (99.8%, 1 min)
Pa-234 (0.2%, 7 h)]
Terminal Nuclide or
Radionuclide'
Nuclide
Pb-208
Bi-209
Pa-231
U-234
Half-life
(yr)
*
*
3.4 x 10*
2.4 x 105
   Radionuclides with half-lives greater than six months. "+D" designates principal radionuclides with
   associated decay chains.
   The chain of decay products of a principal radionuclide extending to (but not including) the next principal
   radionuclide or a stable radionuclide. Half-lives are given in parentheses. Branches are indicated by
   square brackets with branching ratios in parentheses.
   The principal radionuclide or stable nuclide that terminates an associated decay chain.  Stable nuclides are
   indicated by an asterisk (*) in place of a half-life.
   A hyphen indicates that there are no associated decay products.
   The branching decay for Pu-241 and Cm-243 involves multiple principal radionuclides and associated
   radionuclides.
*  Table adapted from:  C. Yu, et al. (1994), "Manual for Implementing Residual Radioactive Materials
   Guidelines Using RESRAD, Version 5.0," Argonne National Laboratory.
                                              -41-

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                          Exhibit 2. EPA Radiation Program Staff
TomD'Avanzo                                                               (617)565-4502
Radiation Program Manager, Region 1
U.S. Environmental Protection Agency
John F. Kennedy Federal Building/ATR
One Congress Street
Boston, MA  02203

Paul A. Giardina                                                              (212) 264-4110
Radiation Program Manager, Region 2
U.S. Environmental Protection Agency/lOOSA
26 Federal Plaza
New York, NY 10278

Lewis Felleisen                                                               (215) 597-8326
Radiation Program Manager, Region 3
Special Program Section (3ATI 2)
U.S. Environmental Protection Agency
841 Chestnut Street
Philadelphia, PA 19107

Paul Wagner                                                                 (404) 347-3907
Radiation Program Manager, Region 4
U.S. Environmental Protection Agency
345 Courtland Street, NE
Atlanta, GA 30365

JackBarnette                                                                (312)886-6175
Radiation Program Manager, Region 5
U.S. Environmental Protection Agency
77 West Jackson Boulevard/ATI 8J
Chicago, IL 60604-3507

Donna Ascenzi                                                               (214) 655-7224
Radiation Program Manger, Region 6
U.S. Environmental Protection Agency
Air Enforcement Branch (6T-E)
1445 Ross Avenue
Dallas, TX 75202-2733

Robert Dye                                                                  (913)551-7605
Radiation Program Manager, Region 7
U.S. Environmental Protection Agency
726 Minnesota Avenue/ARTXARBR
Kansas City, KS 66101
                                           -42-

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                                   Exhibit 2 (Continued)
Milton W. Lammering                                                          (303) 293-1440
Radiation Program Manager, Region 8
(8HWM-RP)
U.S. Environmental Protection Agency
Suite 500
999 18th Street
Denver, CO 80202-2405

Michael S. Bandrowski                                                         (415) 744-1048
Radiation Program Manager, Region 9
(Al-1)
U.S. Environmental Protection Agency
75 Hawthorne Street
San Francisco, CA 94105

Jerry Leitch                                                                   (206) 442-7660
Radiation Program Manager, Region 10
(AT-082)
U.S. Environmental Protection Agency
1200 Sixth Avenue
Seattle, WA 98101

Samuel T. Windham, Director                                                   (205) 270-3402
Office of Radiation and Indoor Air
National Air and Radiation Environmental Laboratory (NAREL)
U.S. Environmental Protection Agency
540 South Morris Avenue
Montgomery, AL 36115-2601

Jed Harrison, Director                                                          (702) 798-2476
Office of Radiation and Indoor Air
Las Vegas Laboratory
EPA Facilities
P.O. Box 98516
Las Vegas, NV 89193-8516

Michael Boyd                                                                 (202) 233-9395
Office of Radiation and Indoor Air (6603 J)
U.S. Environmental Protection Agency
401 M Street, SW
Washington, DC 20460
                                           -43-

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                                                                      I^TOE
CHEMICAL  DOSE
LEVEL     ROUTE
GLYCIDALDEHYDE
NOAEL    10 PPM
        INHALATION:
        INTERMITTENT
                                      Example  Data  and  References  for  Chemical  Toxicity
                         HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
SPECIES
EXPERIMENT LENGTH TARGET
  000765-34-4
 RAT
 12 WEEKS    WHOLE BODY
           BLOOD
           KIDNEY
    CRITICAL EFFECT
       Subchronic            Chronic
   [RfC]       [RfD]     [RfC]      [RfD]      REFERENCE
   (ma/cu M) (inq/lcQ/dav) (na/ai •)  (jM/ka/dav)
UF         UF       UF        UF
                     1E-2       4E-3      1E-3       IRIS
DECREASED WEIGHT GAIN       300       300        3000
HEMATOPOIETIC EFFECTS
EFFECTS
                                    005968
        SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
        CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
        GENERAL COMMENT:  ALSO SEE TABLE 3: CARCINOGENICITY.
                                                                                                            January 1992
                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER  THAN CARCINOGENICITY)
                                                                                                            January 1992
GLYCIDALDEHYDE              000765-34-4
        005968  HINE CH.  RJ GUZMAN. MK DUNLAP. R LIMA AND GS LOQUVAM.  1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH ENVIRON HEALTH
               2: 23-30.

               US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT. National Center for Environmental Assessment. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE. WASHINGTON. DC.

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                                                                         FIGURE  2
                                                Example  Data and References  for  Carcinogenicity
                                                         HEAST TABLE  3:  CARCINOGENICITY
                  EXPERIMENT LENGTH
CHEMICAL ROUTE          SPECIES     TARGET               CANCER
DIMETHYLHYDRAZINE.1.2-      000077-78-1
        ORAL: DRINKING  LIFETIME
        WATER
                       MOUSE      CARDIOVASCULAR       TUMORS
                                  SYSTEM
        Inhalation [Slope] Coument:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            [SLOPE FACTOR]
  [EPA     ORAL     INHALATION
GROUP]  (mg/kg/day) '(ing/kg/day)'
 B2
3.7E+1
3.7E+1
                                                                    January 1992
                          [UNIT RISK]
                        ORAL  INHALATION   REFERENCE
                        (ug/L)'1 (ug/cu •)•'
1.1E-3
1.1E-2  009993
                                               REFERENCES  FOR HEAST TABLE 3:   CARCINOGENICITY
                                                                    January  1992
DIMETHYLHYDRAZINE.  1.2-                 000077-78-1
        009993  TOTH B AND K PATEL.  1982. CARCINOGENICITY DOSE-RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF 1.2-DIMETHYLHYDRAZINE
               DI-HYDROCHLORIDE IN  MICE. I. LIGHT AND TRANSMISSION  ELECTRON MICROSCOPIC STUDY OF COLONOIC NEOPLASMS. AM. J. OF PATH.
               84:69-86.

               US EPA.  1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
        IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513)  569-7254.  FTS 684-7254.

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                                  HEAST  TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                             May 1995
 CHEMICAL     BQSI          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
 ACENAPHTHENE
     NOAEL 175 MG/KG/DAY        MOUSE
              ORAL: GAVAGE      90  DAYS
              TARGET

       000083-32-9

             LIVER
CRITICAL  EFFECT
                                                            HEPATOTOXICITY
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
(mg/cu m)  (mq/ka/dav)   (ma/cu m)  (mg/ka/dav)
   UF         UF          UF         UF
                                                                                                      6E-1
                                                                                                      300
                                                                                            IRIS
                                                                          010165
ACENAPTHYLENE                      000208-96-8
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                     005202
ACEPHATE
     LOAEL 2 PPM
             ORAL: DIET
       030560-19-1
RAT
13 WEEKS
                                            BRAIN
 DECREASED CHOLINESTERASE
 ACTIVITY
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      4E-3
                                                                                                      30
                                                                                            IRIS
                                           005833
ACETONE
     NOEL  100 MG/KG/DAY
             ORAL: GAVAGE
       000067-64-1
RAT
90 DAYS
LIVER
KIDNEY
KIDNEY
INCREASED WEIGHT
INCREASED WEIGHT
NEPHROTOXICITY
                                                                                                      1E+0
                                                                                                      100
                                                                                            IRIS
                                                                          005204
ACETONE  CYANOHYDRIN   / (2-METHYLLACTONITRILE)
     NOAEL 8.75 MG/CKG-DAY)     RAT
             ORAL: GAVAGE     90 DAYS      LIVER
                                     000075-86-5

                             INCREASED RELATIVE WEIGHT
                                                                                                     8E-3
                                                                                                     300
                                                                                            8E-4
                                                                                            3000
                                                                          005776
            SUBCHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE  2: ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfC]  COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS --  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-1

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                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL    DOSE           SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
              TARGET
CRITICAL EFFECT
          Subchronic
  [RfC]      [RfD]
(mQ/cu m)  (ma/kg/day)
   UF         UF
      Chronic
 [RfC]        [RfD]
(mo/cu in)  (ma/ka/dav)
   UF        UF
                                                                                                                                         REFERENCE
ACETONITRILE
     NOAEL 100 PPM
              INHALATION:
              INTERMITTENT
       000075-05-8
 MOUSE
92 DAYS       ERYTHROCYTES
              BLOOD
              LIVER
 DECREASED CELL  COUNT
 DECREASED HEMATOCRIT
 HEPATIC LESIONS
            6E-2
            300
                                                                 IRIS
                                            005210
             SUBCHRONIC [RfC] COMMENT-  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
             SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE  EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
             CHRONIC [RfC] COMMENT-  ALSO SEE HEAST TABLE 2: ALTERNATE  METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
             CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.  UNDER REVIEW. CURRENT NUMBER SUBJECT TO
                                     CHANGE.
ACETOPHENONE
     NOAEL 10.000 PPM
              ORAL: DIET
        000098-86-2
 RAT
17 WEEKS
 NONE OBSERVED
            1E+0
            300
                                                                  IRIS
             CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP.
                     005212


                     010874
 ACROLEIN                             000107-02-8
     NOAEL 15.6 MG/KG/DAY       RAT
              ORAL:  WATER      90 DAYS

             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                               2E-2
                                                                                               1000
                                                                                                                   IRIS
                                                                             010390
                                                                                                         010856
 IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                    1-2

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
 CHEMICAL     DQS£          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT
ACRYLAHIDE                          000079-06-1
     NOEL  0.2 MG/KG/DAY        RAT
              ORAL:  DRINKING    90 DAYS      NERVE            DAMAGE
              WATER

            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                      Subchronic          Chronic
                                                               [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                                             (IT»/CU m) (iro/kci/dav)   (ma/cu m)  (ma/kq/dav)
                                                               UF         UF           UF        UF
                                                                        2E-3
                                                                        100
                                                                IRIS       005835
                                                                                                                 IRIS
             CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (09/20/90) BY THE RfD/RfC WORK GROUP.
                                                                                                        010876
ACRYLIC ACID
     NOAEL 53 MG/KG/DAY
             ORAL: DRINKING
             WATER
       000079-10-7
 RAT
2 GENERATION  WHOLE BODY
                                           5E-1
                                           100
                                                DECREASED PUP WEIGHT


SUBCHRONIC [RfD] COMMENT:  THE CHRONIC  ORAL RfD ON IRIS WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                                              IRIS
005836
     LOAEL 5 PPM               MOUSE
              INHALATION:       13 WEEKS
              INTERMITTENT
             NASAL MUCOSA     LESIONS
                                3E-3
                                100
ACRYLONITRILE
     NOAEL 1 MG/CKG-DAY)        MOUSE
             ORAL: GAVAGE      60 DAYS
       000107-13-1

             TESTES
             TESTES
DECREASED SPERM COUNTS
SEMINIFEROUS  TUBULE
DEGENERATION
                                                                                                       1E-2
                                                                                                       100
                                                                                                      IRIS
                                                                                                                1E-3
                                                                                                                1000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD]  UNDER REVIEW BY THE RfD/RfC WORK  GROUP WAS MODIFIED TO ESTIMATE THE
                        SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY
010346
010939
ADIPONITRILE                        000111-69-3
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                        005157
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                    1-3

-------
                                  HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN  CARCIN06ENICITY)
                                                                                                               May 1995
CHEMICAL    DOSE           SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
                                                              [RfC]
                                          Subchronic
                                            [RfD]
                              Chronic
                        [RfC]       [RfD]
                                                                                                                                         REFERENCE
              TARGET
CRITICAL EFFECT
(mq/cu m)  (ma/kg/dav)   (ma/cu m) (mo/ka/dav)
                                                                                              UF
                                                                          UF
                                                          UF
                                     UF
ALACHLOR
     NOEL  1  MG/KG/DAY
             ORAL: CAPSULE
       015972-60-8
DOG
1  YEAR       BLOOD           ANEMIA
             SITES. MULTIPLE  HEMOSIDEROSIS
                                            1E-2
                                            100
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
ALDICARB
     NOAEL 0.01  MG/KG-DAY       HUMAN
             ORAL              ACUTE
       000116-06-3
             CENTRAL NERVOUS  SWEATING
             SYSTEM
                                            1E-3
                                            10
                                 IRIS
005837
                                                                                              IRIS
                                            010960
            SUBCHRONIC [RfD] COMMENT:. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
            GENERAL COMMENT:  CLINICAL SIGNS OF ACETYL CHOLINESTERASE  INHIBITION INCLUDING SWEATING. PINPOINT PUPILS. LEG WEAKNESS.  NAUSEA. DIARRHEA
                               AND OTHER EFFECTS WERE OBSERVED IN THE PRINCIPAL AND SUPPORTING STUDIES.
ALORIN                               000309-00-2
     LOAEL 0.025 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS      LIVER
                              LESIONS
                                            3E-5
                                            1000
                                  IRIS
                                                                                                         005159
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ALLIDOCHLOR                         000093-71-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                         005838
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                    1-4

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                            May 1995
 OEtlKAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 ALLYL ALCOHOL                      000107-18-6
     NOEL  50 PPM              RAT
             ORAL: DRINKING    15 WEEKS     LIVER
             WATER                         KIDNEY
                                              CRITICAL EFFECT
                             EFFECTS
                             EFFECTS
          Subchronic          Chronic
  [RfC]      [RfD]        [RfC]       [RfD]     REFERENCE
(HM/CU m)  (ma/ko/dav)   (ma/cu m) (ma/ko/dav)
   UF         UF          UF        UF
                                                                                        5E-2
                                                                                        100
                                IRIS
005839
 ALLYL  CHLORIDE
     NOAEL 17 MG/CU M
              INHALATION:
              INTERMITTENT
       000107-05-1
 RABBIT
5 MONTHS
                               NERVOUS  SYSTEM   NEUROTOXICITY


GENERAL COMMENT:  ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
                                                            1E-2
                                                            300
                      IRIS
010369
ALUMINUM                            007429-90-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                    005162
ALUMINUM PHOSPHIDE
     NOAEL 0.43 MG/KG/DAY       RAT
             ORAL: DIET       2 YEARS
       020859-73-8

             WHOLE BODY
             UNSPECIFIED
                                               ALTERED WEIGHT
                                               ALTERED CLINICAL PARAMETERS
                                                                                                     4E-4
                                                                                                     100
                                IRIS
010255
AHETRYN
     NOEL  10 MG/KG/DAY
             ORAL: GAVAGE
       000834-12-8
 RAT
13 WEEKS
                               LIVER
                                                           EFFECTS
AMINO-2-NAPHTHOL. 1-              002834-92-6
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                     9E-2
                                                                                                     100
                                                                                           IRIS
                                                                                                                       005841
                                                                                                                                    005842
AMINO-2-NAPHTOL HYDROCHLORIDE.  1-      001198-27-2
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                    005843
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                1-5

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May  1995
CHEMICAL    DQS1           SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
              TARGET
CRITICAL EFFECT
          Subchronic
  [RfC]      [RfO]
(IHQ/CU in)  (ma/ka/dav)
   UF         UF
      Chronic
 [RfC]        [RfD]
(mq/cu m)  (ma/kg/dav)
   UF        UF
                                                                                                                                        REFERENCE
AMINOPHENOL. M-
     NOAEL 1300 PPM
             ORAL:  DIET
       000591-27-5
RAT
13 WEEKS      WHOLE BODY
             THYROID
 ALTERED WEIGHT
 ALTERED WEIGHT
            7E-1
            100
          7E-2
          1000
                                                                           005844
AMINOPHENOL.  0-                    000095-55-6
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                        005845
AMINOPHENOL.  P-                    000123-30-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                        005846
AMINOPYRIDINE. 4-
     NOAEL 3 PPM
             ORAL: DIET
AMMONIA
     NOAEL 34 MG/L
              ORAL: DRINKING
              WATER
        000504-24-5
RAT
90 DAYS LIVER
BRAIN
007664-41-7
HUMAN
SENSORY
INCREASED WEIGHT
INCREASED WEIGHT
TASTE THRESHOLD
2E-4
1000
34 MG/L
1
2E-5
10000
34 MG/L
1
             SUBCHRONIC [RfD] COMMENT:   GIVEN AS CONCENTRATION  IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD.
                              SAFE CONCENTRATION MAY BE HIGHER. BUT DATA ARE INADEQUATE  TO ASSESS.
             CHRONIC  [RfD] COMMENT:  GIVEN AS CONCENTRATION IN  DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD.
                              SAFE CONCENTRATION MAY BE HIGHER. BUT DATA ARE INADEQUATE  TO ASSESS
     NOAEL 6.4 MG/CU M
              INHALATION:
              INTERMITTENT
 HUMAN
              NASAL CAVITY
              LUNGS
              LUNGS
  RHINITIS
  PNEUMONIA
  LESIONS
  1E-1
  30
                                                                                   IRIS
                                                                                                        005847
                                                                                                        005166
                                                                            010392
 IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                   1-6

-------
                                   HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGEN1CITY)
 CHEMICAL
 LEVEL
COSE          SPECIES
ROUTE    EXPERIMENT LENGTH
                                              TARGET
 ANILINE
      NOAEL 19 MG/CU M
               INHALATION:
               INTERMITTENT
                          000062-53-3
                   MOUSE
                  20-26 WEEKS   SPLEEN
                                RAT
                                20-26 WEEKS

                                GUINEA PIG
                                20-26 WEEKS
                               SPLEEN
                               SPLEEN
                CRITICAL EFFECT




                 PATHOLOGY


                 PATHOLOGY


                 PATHOLOGY
          Subchronic
  [RfC]      [RfD]
(mq/cu m)  (ina/ka/dav)
   UF          UF
                                                                                1E-2
                                                                                300
       Chronic
 [RfC]        [RfD]
(mq/cu  m)  (mg/ka/dav)
   UF        UF
                                                                                                  May 1995


                                                                                             REFERENCE
                      IRIS
                     010370
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
 ANTHRACENE
      NOEL  1000 MG/KG/OAY       MOUSE
              ORAL:  GAVAGE      90 DAYS
                         000120-12-7
                                                             NONE OBSERVED                              3E+0                  IRIS
                                                                                                        300

             CHRONIC [RfC] COMMENT:  THE CHRONIC  INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94)  BY  THE RfD/RfC WORK GROUP.
ANTIMONY PENTOXIDE
     LOAEL 0.46 MG/KG/DAY
              ORAL: DRINKING
              WATER
                         001314-60-9
                  RAT
                 LIFETIME
WHOLE BODY
BLOOD
                                               INCREASED MORTALITY
                                               ALTERED CHEMISTRIES
           5E-4
           1000
         5E-4
         1000
010166


010964




005174
             SUBCHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT
             CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO ANTIMONY  BY CORRECTING FOR DIFFERENCES IN  MOLECULAR WEIGHT.
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                     1-7

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                 May 1995
CHEMICAL
LEVEL
ROUTE
                          SPECIES
                     EXPERIMENT LENGTH
                                TARGET
CRITICAL EFFECT
          Subchronic
  [RfC]      [RfD]
(mg/cu m)  (ma/ka/dav)
   UF         UF
      Chronic
 [RfC]        [RfD]
(mo/cu m)  (ma/kq/dav)
   UF        UF
                                                                                                                                         REFERENCE
ANTIMONY  POTASSIUM  TARTRATE      000304-61-0
     LOAEL  0.91 MG/KG/DAY       RAT
             ORAL: DRINKING    LIFETIME      WHOLE BODY
             WATER                          BLOOD
                                                INCREASED MORTALITY
                                                ALTERED CHEMISTRIES
                                                                                                       9E-4
                                                                                                       1000
                                                                 9E-4
                                                                 1000
                                                                                                                           005234
            SUBCHRONIC [RfD] COMMENT-  CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
            CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY  TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ANTIMONY TETROXIDE
     LOAEL 0.44 MG/KG/DAY
             ORAL: DRINKING
             WATER
                          001332-81-6
                   RAT
                   LIFETIME
                                            WHOLE BODY
                                            BLOOD
  INCREASED MORTALITY
  ALTERED CHEMISTRIES
            4E-4
            1000
          4E-4
          1000
                                                                                                                                       005238
             SUBCHRONIC [RfD] COMMENT-   CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
             CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO ANTIMONY  BY CORRECTING FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
 ANTIMONY TRIOXIDE
     LOAEL 0.42 MG/KG/DAY
              ORAL:  DRINKING
              WATER
                          001309-64-4
                   RAT
                   LIFETIME
                                             WHOLE BODY
                                             BLOOD
  INCREASED MORTALITY
  ALTERED CHEMISTRIES
             4E-4
             1000
           4E-4
           1000
                                                                                                                                        005242
             SUBCHRONIC  [RfD] COMMENT-  CALCULATED BY ANALOGY TO ANTIMONY BY  CORRECTING FOR DIFFERENCES IN  MOLECULAR WEIGHT.
             CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
 ANTIMONY.  METALLIC
      LOAEL 0.35 MG SB/KG/DAY
              ORAL:  DRINKING
              WATER
                           007440-36-0
                    RAT
                   LIFETIME
                                             WHOLE BODY
                                             BLOOD
  INCREASED MORTALITY
  ALTERED CHEMISTRIES
             4E-4
             1000
                                                                                                                             IRIS
                                                                             005170
 IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RIS£ INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                   1-8

-------
                                   HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
 CHEMICAL     CQSI          SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
 ARAMITE
      NQAEL 100 PPM
              ORAL: DIET
      NOAEL 500  PPM
              ORAL:  DIET
       000140-57-8
 RAT
104 WEEKS     LIVER
 DOG
52 WEEKS
                                                            CRITICAL EFFECT
                                                             INCREASED WEIGHT
                                                               Subchronic          Chronic
                                                       [RfC]      [RfD]        [RfC]        [RfD]     REFERENCE
                                                      (mq/cu m) (mq/ka/dav)   (mg/cu m)  (ma/ka/dav)
                                                        UF         UF          UF         UF
                                             LIVER            DEGENERATION


             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                        1E-1
                                                                        100
 AROCLOR  1248                      012672-29-6

             CHRONIC RfD COMMENT:  THE CHRONIC ORAL RfD IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP
 AROCLOR 1254
      LOAEL 0.005 MG/KG/DAY
              ORAL:  CAPSULE     MONKEY
                               >5 YEARS
      011097-69-1

             IMMUNE SYSTEM    TOXICITY
                                                                       5E-5
                                                                       100
             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE  THE SUBCHRONIC ORAL [RfD].
ARSENIC.  INORGANIC
     NOAEL 0.009 MG/L
             ORAL
HUMAN
007440-38-2

      SKIN
      SKIN
                                                            KERATOSIS
                                                            HYPERPIGMENTATION
                                                                       3E-
                                                                       3
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                                             5E-2
                                                                                                                             100
                                                                                             IRIS
                                                                                                        005850
                                                                                                 005849
                                                                                                                                       010940
                                                                                      IRIS       010963
IRIS       010434
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                  1-9

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May  1995
CHEMICAL    CQSt          SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
             TARGET
ATRAZINE
     NOEL  3.5 MG/KG/DAY        RAT
             ORAL: DIET        2  YEARS
       001912-24-9

             WHOLE BODY
                                              CRITICAL EFFECT
                                               DECREASED WEIGHT GAIN
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]    REFERENCE
(ma/cu m)  (ma/ka/dav)   (ma/cu m) (ma/ka/dav)
   UF         UF           UF         UF
            3.5E-2
            100
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
BARIUM                               007440-39-3
     NOAEL 0.21 MG/KG/DAY        HUMAN
             ORAL: WATER       10 WEEKS
             CARDIOVASCULAR   INCREASED BLOOD PRESSURE
             SYSTEM
                                                                                          7E-2
                                                                                          3
                                                                                                               IRIS
                                            010855
                                                                                             IRIS
                                                                                                                          010348
             SUBCHRONIC [RfC] COMMENT-   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
             SUBCHRONIC [RfD] COMMENT-   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
             CHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
 BARIUH CYANIDE                      000542-62-1
             CHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/20/93)  BY THE RfD/RfC WORK GROUP.
                                                                                                        010941
 BENEFIN
      NOAEL 25 MG/KG/DAY
              ORAL:  DIET
       001861-40-1
DOG
1  YEAR
                                ERYTHROCYTE      DECREASED COUNT


SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
             3E-1
             100
                                                                                                                IRIS
                                             005852
 BENZAL CHLORIDE                    000098-87-3
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                        005853
 IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                  1-10

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                 May 1995
             DOSE          SPECIES
LEVEL        ROUTE    EXPERIMENT LENGTH       TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(ma/cu in)  (md/ka/dav)   (ma/cu m)  (mg/ka/dav)
   UF          UF           UF        UF
         BENZALDEHYDE                       000100-52-7
     NOEL  200 MG/KG/DAY        RAT
              ORAL: GAVAGE      13 WEEKS      KIDNEY          EFFECTS
                                            FORESTOMACH     LESIONS
                                           1E+0
                                           100
             SUBCHRONIC [RfD] CPMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].

BENZALDEHYDE  CYANOHYDRIN         000532-28-5
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                 IRIS      005854
                                                                           005781
BENZENE                              000071-43-2
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUNO HEALTH RISK TECHNICAL  SUPPORT CENTER: (513)  569-7300
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
BENZENETHIOL  / (THIOPHENOL)       000108-98-5
     LOAEL 0.1 MG/(KG-DAY)      RAT
             ORAL: GAVAGE      90 DAYS       LIVER
 CENTRILOBULAR EOSINOPHILIC
 CHANGES
                                                                                                       1E-4
                                                                                                       1000
                                 1E-5
                                 10.000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] UNDER REVIEW BY THE  RfD/RfC WORKGROUP WAS MODIFIED TO ESTIMATE THE
                                SUBCHRONIC ORAL [RfD].
          010942
BENZIDINE     '                      000092-87-5
     LOAEL 2.7 MG/KG/DAY        MOUSE
             ORAL: DRINKING    33 MONTHS     BRAIN
             WATER                          LIVER
 CELLULAR CHANGES
 CELLULAR CHANGES
            3E-3
            1000
IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (03/28/91) BY THE  RfD/RfC WORK GROUP.
005830
                                                                           010877
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                     1-11

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
             TARGET
CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(IDQ/CLI m)  (ma/kq/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
BENZO[A]ANTHRACENE                 000056-55-3
            CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP.
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                       010965
BENZOIC  ACID
     NOAEL 312 MG/DAY
             ORAL: DIET
       000065-85-0
HUMAN
                             NONE OBSERVED
                                           4E+0
                                           1
                                                                                             IRIS
            SUBCHRONIC [RfD] COMMENT:  THE HUMAN DAILY  PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE  LEVEL. THE CHRONIC ORAL RfD
                              WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            CHRONIC [RfD] COMMENT:  THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL.


BENZO[B]FLUORANTHENE              000205-99-2
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513)  569-7300.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                           005260
BENZYL ALCOHOL
     LOAEL 286 MG/KG/DAY
             ORAL: GAVAGE
       000100-51-6
RAT
103 WEEKS     FORESTOMACH     EPITHELIAL HYPERPLASIA
                                                                 3E-1
                                                                 1000
                                            005855
     NOAEL 143 MG/KG/DAY         RAT
             ORAL: GAVAGE      13 WEEKS
             WHOLE BODY
 DECREASED WEIGHT
            1E+0
            100
                                                                                                       005856
 IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                  1-12

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)                  May 1995

                                                                                                    Subchronic           Chronic
CHEMICAL     DOSE.          SPECIES                                                           [RfC]      [RfD]       [RfC]       [RfD]    REFERENCE
LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL EFFECT                 (mo/cu m) (tng/kg/dav)   (ma/cu m) (mg/ka/dav)
                                                                                             UF         UF          UF        UF

BERYLLIUM                           007440-41-7
     NOAEL 0.54 MG/KG/DAY       RAT
             ORAL: DRINKING    LIFETIME                      NONE OBSERVED                              5E-3                 IRIS       005262
             WATER                                                                                    100

            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED  AS THE SUBCHRONIC ORAL  [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.


BIPHENYL.  1.1'                      000092-52-4
     NOAEL 50 MG/KG/DAY         RAT
             ORAL: DIET        700 DAYS      KIDNEY           DAMAGE                                    5E-2                 IRIS       005857
                                                                                                      1000

            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED  AS THE SUBCHRONIC ORAL  [RfD].
                                                                                                                 IRIS                  010878
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (09/20/90)  BY THE RfD/RfC  WORK GROUP.


BIS(2-CHLOROISOPROPYL) ETHER     039638-32-9
     NOAEL 35.8 MG/KG/DAY       MOUSE
             ORAL: DIET        2 YEARS       ERYTHROCYTES     DECREASED  HEMOGLOBIN                       4E-2                 IRIS       010257
                                                                                                      1000

            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

BIS(2-ETHYLHEXYL)  PHTHALATE /  (DEHP)     000117-81-7
                                                                                                                           IRIS       010859
            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE SUPERFUNO HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            SUBCHRONIC [RfD]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.                    1-13

-------
                                 HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC  TOXICITY (OTHER THAN CARCIN06ENICITY)
                                                                                                                                      May 1995
CHEMICAL    DOSE
LEVEL       ROUTE
                     SPECIES
                EXPERIMENT LENGTH
      TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(ma/cu m)  (ma/kg/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF         UF
BISPHENOL  A

     NOAEL 750 PPM
             ORAL
                          RAT
                         13 WEEKS
000080-05-7


      WHOLE BODY
 DECREASED WEIGHT
            6E-1
            100
                                                                                                                      IRIS
                     005268

                     005266
BORON TRIFLUORIDE
     NOAEL 6 MG/CU M
             INHALATION:
             INTERMITTENT
                                 007637-07-2
                          RAT
                         13 WEEKS
      KIDNEY
 NECROSIS
 7E-3
 300
7E-4
3000
                                                                                                010395
BORON. ELEMENTAL                   007440-42-8
     NOAEL 8.8 MG/KG/DAY        DOG
             ORAL: DIET       2 YEARS       TESTIS
                                                       LESIONS
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                               HUMAN
LOAEL 4.5 MG/CU M
        INHALATION:
        INTERMITTENT
                                            RESPIRATORY
                                            TRACT
                                            BRONCHUS
                      IRRITATION

                      BRONCHITIS
                                2E-2
                                100
                                                                9E-2
                                                                100
            SUBCHRONIC [RfC]  COMMENT:  THE SUBCHRONIC INHALATION [RfC]  IS SPECIFICALLY FOR ANHYDROUS BORAX.
            CHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC] IS SPECIFICALLY FOR ANHYDROUS BORAX.
                      2E-2
                      100
                                                                IRIS
                                           005272
                     005269
BROHINATED DIBENZO-P-DIOXINS
            GENERAL COMMENT:   DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                005858
BRONINATED DIBENZOFURANS
            GENERAL COMMENT:   DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                005859
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                           1-14

-------
                                  HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May  1995
 CHEMICAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT  LENGTH
              TARGET
CRITICAL EFFECT
 BROMOACETONE                       000598-31-2
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu m)  (ma/ka/dav)   (ITIQ/CU m)  (ma/kq/dav)
   UF         UF           UF        UF
                                                                                                                                      005860
 BROMOCHLOROETHANES
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                      005861
BROHODICHLOROHETHANE
     LOAEL 17.9 MG/KG/DAY
             ORAL: GAVAGE
       000075-27-4
MOUSE
102 WEEKS     KIDNEY
                                                            CYTOMEGALY
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BROMOETHENE  / (VINYL BROMIDE)    000593-60-2
     LOAEL 9.7 PPM             RAT
              INHALATION:       24 MONTHS
              INTERMITTENT
             LIVER
             LIVER
             LIVER
 HYPERTROPHY
 BASOPHILIC FOCI
 EOSINOPHILIC FOCI
 3E-3
 3000
                                                                        2E-2
                                                                        1000
            SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC  INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC]
            GENERAL COMMENT:   ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
BROMOFORM                           000075-25-2
     NOEL  17.9 MG/KG/DAY       RAT
             ORAL: GAVAGE      13 WEEKS      LIVER
                             EFFECTS
                                                                                                      2E-1
                                                                                                      100
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS
                                                                                                                            IRIS
                                                                                             IRIS
                                                                           005715
010929
                                                                           005722
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP.
                                                                                                       010961
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-15

-------
                                 HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER  THAN  CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DQSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (ma/ka/dav)   (mo/cu m)  (ma/kg/dav)
   UF          UF           UF        UF
BROHOHETHANE
       000074-83-9
            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            SUBCHRONIC [RfD]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
                                                                                                                 IRIS
                                                                                                                           IRIS
                                                                                                       010861
                                                                                                       010860
BROMOPHENYL PHENYL  ETHER.  4-     000101-55-3
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       005864
BROMOPHOS
     NOAEL 5 MG/KG/DAY
             ORAL: DIET
       002104-96-3
 RAT
3            BLOOD
GENERATIONS
             LIVER
 DECREASED CHOLINESTERASE
 ACTIVITY
 DECREASED CHOLINESTERASE
 ACTIVITY
            SUBCHRONIC [RfD] COMMENT:  BASED ON A REPRODUCTION STUDY.
            CHRONIC [RfD] COMMENT:   BASED ON A REPRODUCTION STUDY.
 BROMOXYNIL                          001689-84-5
     NOEL  5 MG/KG/DAY          RAT
              ORAL: DIET        2 YEARS
                              NONE OBSERVED
            5E-2
            100
                                            2E-2
                                            300
             SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
5E-3
1000
                                                                                             IRIS
                                                                           005865
                                                                           005866
 MS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                 1-16

-------
                                  HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                      May 1995
 CHEMICAL    fiQSl          SPECIES-
 LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET
                     CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu ro)  (ma/ka/dav)   (ma/cu m)  (mo/kQ/dav)
   UF         UF          UF         UF
 BROMOXYNIL OCTANOATE
      NOEL   7.3 MG/KG/DAY        RAT
              ORAL:  DIET       2 YEARS
001689-99-2
                                                            NONE OBSERVED


             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].


 BUSAN 77                            031512-74-0
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT-.


 BUSAN 90                            002491-38-5
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                2E-2
                                                                300
 BUTANOL. 1-
     NOAEL 125 MG/KG/DAY        RAT
             ORAL: GAVAGE      13 WEEKS
000071-36-3
      CENTRAL NERVOUS  HYPOACTIVITY
      SYSTEM
      CENTRAL NERVOUS  ATAXIA
      SYSTEM
                                                                                                      1E+0
                                                                                                      100
                                 IRIS       005867
                                                                                                005868
                                                                                                                                     005869
                                IRIS       005870
BUTYL BENZYL  PHTHALATE.  N-        000085-68-7
     NOAEL 159 MG/KG/DAY        RAT
             ORAL: DIET       26 WEEKS      LIVER
                      ALTERED WEIGHT
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      2E+0
                                                                                                      100
                                                                                     IRIS
                                           005616
IRK.  EPA-S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                               1-17

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                               May 1995
CHEMICAL     DQSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                              (ma/cu m)  (ma/ka/day)   (ma/cu m)  (ma/ka/dav)
                                 UF          UF           UF         UF
BUTYLATE                             002008-41-5
     NOEL  5 MG/KG/OAY          DOG
             ORAL: CAPSULE      12 MONTHS     LIVER            INCREASED RELATIVE WEIGHT


            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                          5E-2
                                          100
                                                               IRIS      005871
BUTYLCHLORIDE.  T-                  000507-20-0
            GENERAL COMMENT:   DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                          005810
BUTYROLACTONE.  GAMMA-             000096-48-0
            GENERAL COMMENT:   DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                          005872
CACODYLIC ACID                     000075-60-5
     NOEL  9.2 MG/KG/DAY        RAT
             ORAL: DIET        90 DAYS
NONE OBSERVED
3E-2
300
             SUBCHRONIC [RfD] COMMENT-  CALCULATED BY ANALOGY TO ARSENIC BY  CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
             CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
3E-3
3000
                                                                          005873
 CADMIUM                             007440-43-9
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                       IRIS
                       005280
 IRIS.  EPA-S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                     1-18

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)                  May 1995

                                                                                                     Subchronic           Chronic
CHEMICAL    DOSE           SPECIES                                                            [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
LEVEL       ROUTE     EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT                 (iro/cu m)  (ma/ka/dav)   (ma/cu m)  (ma/ka/day)
                                                                                              UF        UF           UF        UF

CALCIUM CYANIDE                    000592-01-8
     NOAEL  19.1 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS       WHOLE BODY       DECREASED WEIGHT                           4E-2                  IRIS       010258
                                            THYROID         EFFECTS                                    500
                                            NERVE           MYELIN DEGENERATION

            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
                              THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD]
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.


CAPROLACTAH                         000105-60-2
                                                                                                                            IRIS       005284
     NOAEL  50 MG/KG/DAY         RAT
             ORAL: DIET        90 DAYS       KIDNEY          EFFECTS                                    5E-1                             005282
                                                                                                       100

                                                                                                                  IRIS                  010966

CAPTAFOL                             002425-06-1
     LOAEL  2 MG/KG/DAY          DOG
             ORAL: CAPSULE     12 MONTHS     KIDNEY          EFFECTS                                    2E-3                  IRIS       005874
                                            BLADDER         EFFECTS                                    1000

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.                     1-19

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN  CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL     DOSE          SPECIES
LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
                      CRITICAL EFFECT
          Subchronic
  [RfC]      [RfD]
(IDQ/CU m)  (mg/kg/dav)
   UF         UF
      Chronic
 [RfC]        [RfD]     REFERENCE
(ma/cu m)  (ma/ka/dav)
   UF        UF
CAPTAN
     NOEL  12.5 MG/KG/DAY
             ORAL: DIET
RAT
000133-06-2

      WHOLE BODY
                             DECREASED WEIGHT
                                                                                                        1.3E-1
                                                                                                        100
                                 IRIS
             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
             CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED  NOT VERIFIABLE (05/27/92) BY THE RfD/RfC WORK GROUP.
             CHRONIC [RfD] COMMENT:  BASED ON A MULTI-GENERATION REPRODUCTION STUDY.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CARBARYL
     NOAEL 9.6 MG/KG/DAY        RAT
             ORAL: DIET        2 YEARS
       000063-25-2

             KIDNEY
             LIVER
                      TOXICITY
                      TOXICITY
            1E-1
            100
                                                                                                                             IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                                                                   IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (08/15/91) BY THE RfD/RfC WORK GROUP.
                                                                                                 005875
                     005876
                                                                                                        010882
CARBOFURAN
     NOEL  0.5 MG/KG/DAY         DOG
             ORAL: DIET        1 YEAR
       001563-66-2

             BLOOD
             TESTIS
             UTERUS
                      CHOLINESTERASE INHIBITION
                      EFFECTS
                      EFFECTS
            5E-3
            100
          IRIS
                                                                                                                                        005877
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS  THE SUBCHRONIC ORAL [RfD].
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-20

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
 CHEMICAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 CARBON DISULFIDE
     NOEL  11 MG/KG/DAY
              INHALATION:
              INTERMITTENT
        000075-15-0
 RABBIT
             FETUS
CRITICAL EFFECT
 TOXICITY
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfO]    REFERENCE
(mq/cu m)  (ma/ka/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
                                                                        1E-1
                                                                        100
                                                                 IRIS
             SUBCHRONIC [RfD] COMMENT:   THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
             CHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS DETERMINED FROM A TERATOLOGY STUDY WITH  EXPOSURES BEFORE AND DURING
                              THE ENTIRE GESTATION PERIOD.
     NOAEL 10 MG/CU M
              INHALATION:
              INTERMITTENT
 RAT
GESTATION    FETUS
 TOXICITY
                                                              1E-2
                                                              1000
                                                      1E-2
                                                      1000
             SUBCHRONIC [RfC] COMMENT:   THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
                                            010259
                                            010430
CARBON  MONOXIDE                    000630-05-0
            CHRONIC [RfC] COMMENT:   REFER TO APPENDIX A:  TECHNICAL  INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
                                                                                                        010493
CARBON  TETRACHLORIOE
       000056-23-5
CHLORAL
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER-  (513) 569-7300
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.   .
             LOAEL 15.7 MG/KG/DAY
             ORAL: DRINKING    90 DAYS
             WATER
       000075-87-6

              MOUSE
             LIVER
 EFFECTS
                                                                        2E-2
                                                                        1000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
                                                                                                                             IRIS
                                                                 IRIS
                                                                                                        010862
                                            005290
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                   1-21

-------
                                 HEAST TABLE 1:   SU8CHRONIC  AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                      May  1995
CHEMICAL     DQSE.          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH      TARGET
                     CRITICAL EFFECT
                                        Subchronic           Chronic
                                [RfC]     [RfD]       [RfC]       [RfD]     REFERENCE
                              (mg/cu m)  (inq/kq/dav)   (mo/cu m)  (mq/ka/day)
                                 UF         UF          UF        UF
CHLOROANE                            000057-74-9
     NOEL 0.055 MG/KG/DAY      RAT
             ORAL:  DIET        130 WEEKS     LIVER
                      HYPERTROPHY
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC  ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORINE  CYANIDE
     NOAEL  25.3 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS
000506-77-4

      WHOLE  BODY
      THYROID
      NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC  ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
CHLORO-1.3-BUTADIENE. 2-   /  (CHLOROPRENE)   000126-99-8
     NOAEL 32 PPM               RAT
              INHALATION        90  DAYS       OLFACTORY        DEGENERATION
                                            EPITHELIUM
                                                      7E-2
                                                      30
                                          6E-5
                                          1000
5E-2
500
                                                                                     IRIS      005296
                                                               IRIS
                                                     7E-3
                                                     300
010261
                                                                                                010515
            SUBCHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLORO-M-CRESOL. P-                000059-50-7
     NOAEL 200 MG/KG/DAY        RAT
             ORAL: GAVAGE      28 DAYS       WHOLE BODY
                      DECREASED WEIGHT GAIN
                                          2E+0
                                          100
                                                                                                005366
CHLOROACETALDEHYDE                 000107-20-0
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                005342
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                          1-22

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                              (im/cu m) (mg/ka/dav)   (ma/cu m)  (ma/ka/day)
                                 UF         UF          UF        UF
CHLOROACETIC ACID
     LOAEL  30 MG/KG
             ORAL:  GAVAGE
       000079-11-8
 RAT
13 WEEKS
HEART
MYOCARDITIS
2E-2
1000
2E-3
10000
                                                                                          005346
CHLOROANILINE.  2-                 000095-51-2
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      005347
CHLOROANILINE.  3-                 000108-42-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      005348
CHLOROANILINE.  4-
     LOAEL  12.5 MG/KG/DAY
             ORAL: DIET
       000106-47-8
 RAT
78 WEEKS
SPLEEN
PROLIFERATE  LESIONS
            SUBCHRONIC [RfD] COMMENT:  THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHLOROBENZENE
       000108-90-7
4E-3
3000
IRIS
                                                                                                                           IRIS
                                                                                          005349
                                                                                                       010863
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513)  569-7300.
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513)  569-7300.
            CHRONIC [RfC]  COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-23

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
                                               CRITICAL EFFECT
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]
(mq/cu m)  (mQ/kQ/day)   (mq/cu m) (mq/kq/day?
   UF         UF           UF        UF
                                                                                                               May 1995


                                                                                                          REFERENCE
CHLOROBENZILATE                    000510-15-6
     NOEL  5 MG/KG/DAY           RABBIT
             ORAL: GAVAGE      13 DAYS
                                                                                                       2E-2
                                                                                                       300
                                                                                              IRIS
                                GASTRO-          DECREASED STOOL QUANTITY
                                INTESTINAL  SYSTEM
                                WHOLE BODY       DECREASED FOOD CONSUMPTION
                                WHOLE BODY       DECREASED WEIGHT GAIN
                                NERVOUS  SYSTEM   HYPERIRRITABILITY

SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]. BASED ON A TERATOLOGY STUDY WITH
                   EXPOSURES DURING DAYS 7-19 OF GESTATION.
CHRONIC [RfD]  COMMENT:  BASED ON A TERATOLOGY STUDY WITH EXPOSURES DURING DAYS 7-19 OF GESTATION.

CHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP.
                                            010260
                                                                                                                                       010931
CHLOROBENZOIC  ACID.  P-
     NOAEL 26 MG/DAY
             ORAL: DIET
        000074-11-3
 RAT
5 MONTHS
                                                NONE OBSERVED
                                                                                                       2E+0
                                                                                                       100
                                                                                              2E-1
                                                                                              1000
                                                                                                                           005360
CHLOROBENZOTRIFLUORIDE.  4-       000098-56-6
     NOAEL 15 MG/KG/DAY         RAT
             ORAL: GAVAGE                   KIDNEY
                              TUBULAR DEGENERATION
                                                                                                       2E-1
                                                                                                       100
                                                                                                                2E-2
                                                                                                                1000
            SUBCHRONIC [RfD] COMMENT:  BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING.
                              DURING GESTATION, AND FOR 90  DAYS POST-WEANING.
            CHRONIC [RfD] COMMENT:  BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING.  DURING
                              GESTATION. AND FOR 90 DAYS POST-WEANING.
                                                                                                        005364
MS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                   1-24

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER  THAN  CARCINOGENICITY)
LEVEL
             BQSE          SPECIES
             ROUTE    EXPERIMENT LENGTH
                                            TARGET
CRITICAL EFFECT
 CHLOROBUTANE. 1-
      NQAEL 43 MG/KG/DAY
              ORAL: GAVAGE
                                     000109-69-3
                               RAT
                              103 WEEKS    WHOLE BODY       INCREASED MORTALITY
                                           CENTRAL NERVOUS   EFFECTS
                                           SYSTEM
                                           BLOOD            HEMATOLOGIC EFFECTS
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]
(ma/cu m)  (ma/ko/dav)   (IDQ/CU m)  (im/kg/dav)
   UF        UF           UF        UF
                                                                                                                                            May 1995


                                                                                                                                       REFERENCE
                                                                                                                            4E-1
                                                                                                                            100
                                                                           005808
     NOAEL 86 MG/KG/DAY         RAT
              ORAL: GAVAGE      13 WEEKS
                                           WHOLE BODY
                                           CENTRAL NERVOUS
                                           SYSTEM
                                           SPLEEN
 DECREASED WEIGHT GAIN
 EFFECTS

 HEMATOPOIESIS
                                                                                                       9E-1
                                                                                                       100
                                           005806
CHLOROBUTANE.  2-                   000078-86-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                      005809
CHLOROCYCLOPENTADIENE             041851-50-7
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                     005297
CHLOROFORM
     LOAEL 12.9 MG/KG/DAY
             ORAL: CAPSULE
                                     000067-66-3
                              DOG
                              7.5 YEARS     LIVER
                                                            LESIONS
                                                                                                       1E-2
                                                                                                       1000
                                                                                                                           IRIS       005372
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS  THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                1-25

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)                  May  1995

                                                                                                   Subchronic          Chronic
CHEMICAL     DOSE          SPECIES                                                          [RfC]     [RfO]       [RfC]       [RfD]     REFERENCE
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT                 (mq/cu m)  (mq/kq/dav)   (ma/cu m)  (ina/ka/dav)
                                                                                            UF        UF          UF        UF

CHLOROMETHANE /  (METHYL CHLORIDE)    000074-87-3
                                                                                                                                    010005
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUNO HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.


CHLORONITROBENZENE. H-            000121-73-3
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.                                                         005879


CHLORQPHENOL. 2-                  000095-57-8
     NOAEL  50 PPM               RAT
             ORAL-  DRINKING                 REPRODUCTION     REPRODUCTIVE  EFFECTS                       5E-2                 IRIS      010436
             WATER                                                                                   100

            SUBCHRONIC [RfD] COMMENT-  BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING. GESTATION AND WEANING.
            CHRONIC [RfD] COMMENT:  BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE  10 WEEKS PRIOR TO AND DURING MATING.  GESTATION AND WEANING.


CHLOROPHENOL. 3-                  000108-43-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT                                                          005309


CHLOROPHENOL. 4-                  000106-48-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT                                                          005310


CHLOROPROPANE.  2-                 000075-29-6
     NOAEL  91.4 MG/KG/DAY       RAT
             INHALATION:        4 WEEKS      LIVER           EFFECTS                         1E+0                  1E-1                  010444
             INTERMITTENT                                                                   100                  1000

CHLOROTOLUENE.  H-                 000108-41-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.                                                          005880
 IRIS. EP/CS INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK INFORMATION HOTLINE:  (513) 569-7254.                    1-26

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfO]     REFERENCE
                              (mg/cu m) (mg/ka/dav)   (rna/cu m)  (ma/ka/dav)
                                 UF         UF          UF        UF
CHLOROTOLUENE. 0-
     NOAEL 20 MG/KG/DAY
             ORAL:  GAVAGE
       000095-49-8
 RAT
103 DAYS
WHOLE BODY
DECREASED WEIGHT GAIN
2E-1
100
                                                                               IRIS
                                                                          010167
CHLOROTOLUENE.  P-                 000106-43-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       010200
CHLORPYRIFOS                       002921-88-2
     NOEL  0.03 MG/KG/DAY       HUMAN
             ORAL:  CAPSULE     20 DAYS OR    BLOOD
                              9 DAYS
                             DECREASED CHOLINESTERASE
                             ACTIVITY
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                          3E-3
                                                          10
                                                               IRIS       005881
CHLORPYRIFOS METHYL
     NOAEL  1 MG/KG/DAY
             ORAL:  DIET
       005598-13-0
 RAT
3            REPRODUCTION
GENERATIONS
                DECREASED FERTILITY
                                          1E-2
                                          100
                     1E-2       005882
                     100
                              RAT
                              2 YEARS
             LIVER
                EFFECTS
CHLOROTHALONIL                       001897-45-6
     NOEL  1.5 MG/KG/DAY        DOG
             ORAL:  DIET       2 YEARS      KIDNEY
                             EFFECTS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                           1.5E-2
                                                           100
                                                                IRIS       005883
IRIS,  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-27

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN  CARCINOGENICITY)
                                                                                                              May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT
                                                                      Subchronic          Chronic
                                                              [RfC]      [RfO]       [RfC]       [RfD]     REFERENCE
                                                            (mg/cu m) (mq/kq/dav)    (ma/cii m) (im/kg/day)
                                                               UF         UF          UF         UF
CHLORTHIOPHOS                      060238-56-4
     NOAEL 0.08 MG/KG/DAY       RAT
             ORAL: DIET        2  YEARS                       NONE OBSERVED


            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                        8E-4
                                                                        100
                                                                8E-4       005884
                                                                100
CHROMIUM(III)
     NOEL  5 %  (CR203)
             ORAL: DIET
       016065-83-1
 RAT
840 DAYS
NONE OBSERVED
lE-t-0
1000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            CHRONIC [RfC] COMMENT:   INHALATION ISSUES ARE  UNDER REVIEW BY THE RFD/RFC WORK GROUP.
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL  SUPPORT CENTER. (513) 569-7300.
CHROMIUM(VI)
     NOAEL 2.4 MG/KG/DAY
             ORAL: DRINKING
             WATER
       018540-29-9
 RAT
1 YEAR
NONE OBSERVED
2E-2
100
            CHRONIC [RfC] COMMENT:   INHALATION ISSUES ARE UNDER REVIEW BY THE RFD/RFC WORK GROUP.
            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL  SUPPORT CENTER: (513) 569-7300
IRIS
                                                                                                                                       005731
IRIS
                                                                                                        005522
CHRYSENE                             000218-01-9
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                        005885
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-28

-------
 CHEMICAL
 LEVEL
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                                May 1995
DOSE
ROUTE
     SPECIES
EXPERIMENT LENGTH
                                             TARGET
                                               CRITICAL EFFECT
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mq/cu m)  (ma/kq/dav)   (iro/cu m)  (im/kQ/dav)
   UF         UF           UF        UF
COPPER
     LQAEL 5.3 MG
              ORAL
                         007440-50-8
                   HUMAN
                  SINGLE  DOSE   GASTRO-
                                                             IRRITATION
                                                                                          1.3 MG/L
                                                                                                      1.3 MG/L   005374
                                            INTESTINAL SYSTEM
             SUBCHRONIC [RfD] COMMENT:  CURRENT DRINKING WATER STANDARD OF 1.3 MG/L.  DWCD  (1987) CONCLUDED TOXICITY  DATA WERE
                              INADEQUATE FOR CALCULATION OF AN RfD FOR COPPER.
             CHRONIC [RfD] COMMENT:   CURRENT DRINKING WATER STANDARD OF 1.3 MG/L.  DWCD  (1987) CONCLUDED TOXICITY DATA WERE
                              INADEQUATE FOR CALCULATION    OF AN RfO FOR COPPER.
COPPER  CYANIDE
     NOAEL 5 MG/KG/DAY
             ORAL: GAVAGE
                         000544-92-3
RAT
90 DAYS
LIVER
KIDNEY
WHOLE BODY
ORGANS
HISTOPATHOLOGY
HISTOPATHOLOGY
DECREASED WEIGHT
DECREASED WEIGHT
                                                                                                       5E-2
                                                                                                       100
                                                                                                               IRIS
                                                                                                                 010262
CRESOL.  M-   /  (3-METHYLPHENOL)
     NOAEL 50 MG/KG/DAY         RAT
             ORAL: GAVAGE      90  DAYS
                          000108-39-4

                               WHOLE BODY       DECREASED WEIGHT GAIN
                               NERVOUS SYSTEM   NEUROTOXICITY
                                                                                                       5E-1
                                                                                                       100
                                                                                                      IRIS
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                                  IRIS
            CHRONIC RfC COMMENT:   THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE RfD/RfC WORK GROUP.
                                            005380
                                                                                                                          010888
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                    1-29

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                         Subchronic           Chronic
                                 [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                               (mq/cu m)  (mQ/ka/dav)   (mg/cu  m)  (mq/kq/dav)
                                  UF         UF           UF        UF
CRESOL.  0-  /  (2-METHYLPHENOL)   000095-48-7
     NOAEL 50 MG/KG/DAY         RAT
             ORAL: GAVAGE      90 DAYS
              WHOLE BODY       DECREASED WEIGHT GAIN
              NERVOUS SYSTEM   NEUROTOXICITY
            GENERAL COMMENT:   ALSO SEE  HEAST TABLE 3:  CARCINOGENICITY.
                                                           5E-1
                                                           100
                                                                                                                             IRIS
                                                                                                                  IRIS
            CHRONIC RfC COMMENT:   THE  CHRONIC INHALATION RfC  IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE RfD/RfC WORK GROUP.
                                                                           005384
                                                                                                        010889
CRESOL.  P-  /  (4-METHYLPHENOL)   000106-44-5
     NOAEL 5 MG/(KG-DAY)        RABBIT
             ORAL: GAVAGE      GESTATION     CENTRAL NERVOUS  HYPOACTIVITY
                               DAYS  6-18     SYSTEM
                                            RESPIRATORY      DISTRESS
                                            SYSTEM
                                            WHOLE BODY      MATERNAL DEATH

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                        5E-3
                                                                        1000
                                                                                5E-3
                                                                                1000
                                                                           010516
                                                                                                                  IRIS
            CHRONIC RfC COMMENT:   THE  CHRONIC INHALATION  RfC  IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE RfD/RfC WORK GROUP.
                                                                                                        010890
CUMENE
     NOAEL 154 MG/KG/DAY
             ORAL: GAVAGE
     NOAEL 105.1 PPM
             INHALATION:
             INTERMITTENT
        000098-82-8
 RAT
194 DAYS
 RAT
4 WEEKS
KIDNEY
INCREASED WEIGHT
CENTRAL NERVOUS  INVOLVEMENT
SYSTEM
NOSE            IRRITATION
4E-1
300
                                                                                                                            IRIS
                                9E-2
                                1000
                                                                                   9E-3
                                                                                   10000
                                                                                                        005392
                                005908
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                   1-30

-------
                                  HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                              May 1995
LEVEL
             DOSE          SPECIES
             ROUTE    EXPERIMENT LENGTH
                                             TARGET
 CYANAZINE
     NOEL  0.625 MG/KG/DAY      DOG
              ORAL:  DIET       1 YEAR
                                      021725-46-2

                                            WHOLE BODY
                                            BLOOD
                                            BLOOD
CRITICAL EFFECT
 DECREASED WEIGHT
 INCREASED PLATELET COUNT
 ALTERED CLINICAL CHEMISTRY
 PARAMETERS
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mo/cu m)  (ma/kq/dav)   (ma/cu m) (mg/kg/dav)
   UF         UF           UF         UF
                                                                                                        2E-3
                                                                                                        300
                                 2E-3
                                 300
010411
             SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
             CHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS WITHDRAWN FROM IRIS  (07/01/92).  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE
             GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CYANIDE
     NOAEL 10.8 MG/KG/DAY
             ORAL: DIET
                                      000057-12-5
                               RAT
                              104 WEEKS     WHOLE  BODY
                                            THYROID
                                            NERVE
                                                             DECREASED WEIGHT
                                                             EFFECTS
                                                             MYELIN DEGENERATION
                                            2E-2
                                            500
                                 IRIS
005396
            SUBCHRONIC [RfD] COMMENT:   THE  CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  THE CASRN FOR CN- IS 000057-12-5: THE CASRN FOR HCN  IS 000074-90-8
CYANOGEN
     NOAEL 21.6 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS
                                      000460-19-5

                                            WHOLE BODY
                                            THYROID
                                            NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
                                                                                                        4E-2
                                                                                                        500
                                 IRIS
010263
            SUBCHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR  WEIGHT  THE CHRONIC ORAL RfD
                               WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                  1-31

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mo/cu m)  (ma/lca/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
CYANOGEN  BROMIDE
     NOAEL  44 MG/KG/OAY         RAT
             ORAL:  DIET       2 YEARS
       000506-68-3

             WHOLE BODY
             THYROID
             NERVE
 DECREASED WEIGHT
 EFFECTS
 MYELIN DEGENERATION
            9E-2
            500
                                                                IRIS
            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY  TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN  MOLECULAR WEIGHT.
                             THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
010264
CYCLOATE                             001134-23-2
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       005886
CYCLOHEXANOL                        000108-93-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       005887
CYCLOHEXYLANINE

     NOAEL 30 MG/KG/DAY
             ORAL: DIET
       000108-91-8

 RAT
90 DAYS      WHOLE BODY
             TESTIS
 DECREASED WEIGHT GAIN
 DECREASED WEIGHT
            3E-1
            100
                                                                 IRIS
005400

005398
CYCLOPENTADIENE
        000542-92-7
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                      010494
 MS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                  1-32

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                             May 1995
 LEVEL
                           SPECIES
            ROUTE     EXPERIMENT LENGTH
                                             TARGET
                             CRITICAL  EFFECT
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mq/cu m)  (ma/ka/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
DACTHAL
     NQAEL 1  MG/KG/DAY
             ORAL:  DIET
                                      001861-32-1
RAT
2 YEARS






LUNG
LIVER
KIDNEY
THYROID
THYROID
HORMONES

EFFECTS
EFFECTS
EFFECTS
EFFECTS
EFFECTS

                                                                                                       1E-2
                                                                                                       100
                                                                                                                            IRIS
OALAPON
     NOEL  8.45 MG/KG/DAY
             ORAL: DIET
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                                      000075-99-0

                                            KIDNEY           INCREASED RELATIVE WEIGHT
 RAT
2 YEARS
                                                                                                       3E-2
                                                                                                       300
                                                                                              IRIS
            SU8CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO DALAPON SODIUM BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
                              THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DDT
                                      000050-29-3
     NOEL  0.05 MG/KG/DAY       RAT
             ORAL: DIET        27 WEEKS
                                           LIVER
                              LESIONS
                                                                                                       5E-4
                                                                                                       100
                                                                                                                            IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
DECABROMODIPHENYL ETHER           001163-19-5
     NOEL  1  MG/KG/DAY          RAT
             ORAL: DIET        2 YEARS       LIVER
                                                            INCREASED WEIGHT
                                                                                                       1E-2
                                                                                                       100
                                                                                                                            IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                        005888
                                            005889
                                                                                                        005408
                                                                                                        005891
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                 1-33

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                                              May 1995
CHEMICAL
LEVEL
ROUTE
                          SPECIES
                     EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(ma/cu m)  (ma/kq/dav)   (IHQ/CU m)  (ma/ka/dav)
   UF         UF          UF         UF
DI-N-OCTYL  PHTHALATE
     LOAEL  175 MG/KG/DAY
             ORAL:  DIET
                         000117-84-0
                  RAT
                  7-12  MONTHS   KIDNEY
                               LIVER
                               LIVER
                               LIVER
                                                           INCREASED WEIGHT
                                                           INCREASED WEIGHT
                                                           INCREASED SGOT ACTIVITY
                                                           INCREASED SGPT ACTIVITY
                                                         2E-2
                                                         1000
                                                               2E-2
                                                               1000
                                           010275
DIAZINON
     NOAEL 0.09 MG/KG/DAY
            •ORAL:  DIET
                         000333-41-5
                   RAT
                  35-42 DAYS    BLOOD
                                                           DECREASED  CHOLINESTERASE
                                                           ACTIVITY
                                                         9E-4
                                                         100
                                                               9E-4
                                                               100
                                           005892
DIBENZOFURAN                       000132-64-9
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                        005409
DIBROMOBENZENE.  1.4-
     NOAEL  10 MG/KG/DAY
             ORAL:  GAVAGE
                         000106-37-6
                   RAT
                  45 OR 90
                  DAYS
                                           LIVER
                                           LIVER
                INCREASED RELATIVE WEIGHT
               ALTERED ENZYME ACTIVITIES
                                           1E-1
                                           100
                                 IRIS       005893
DIBROHOCHLOROHETHANE
     NOEL  21.4 MG/KG/DAY
             ORAL: GAVAGE
                         000124-48-1
                   RAT
                  13 WEEKS
                                           LIVER
               LESIONS
                                           2E-1
                                           100
                                 IRIS       005894
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3.  CARCINOGENICITY.
MS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                  1-34

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                            May 1995
 CHEMICAL     EQSE          SPECIFY
 LEVEL        ROUTE     EXPERIMENT LENGTH       TARGET
  DIBROMOETHANE. 1.2-               000106-93-4
       LOAEL 88 PPB              HUMAN
               INHALATION:                    SPERM
               INTERMITTENT
                                                           CRITICAL EFFECT
                                                            EFFECTS
                                                                                                     Subchromc          Chronic
                                                                                             [RfC]      [RfDJ       [RfC]       [RfD]     REFERENCE
                                                                                                     (inq/kQ/dav)   (mq/cu m) Imq/ka/dav)
                                                                                                        UF          UF         UF
                                                                                             UF
                                                                                           2E-3
                                                                                           100
                                                                                                                 2E-4
                                                                                                                 1000
                                                                                 £STIMTE TH£
 DIBUTYL  PHTHALATE
      NOAEL 125 MG/KG/DAY
              ORAL:  DIET
                               RAT
                              52 WEEKS
                                      000084-74-2
                                           WHOLE BODY      INCREASED MORTALITY
                                                                                                      1E+0
                                                                                                      100
            CHRONIC RfC COMMENT:  THE  CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE  (07/26/90) BY THE RfD/RfC
DICAHBA
     NOAEL 3 MG/KG/DAY
             ORAL:. GAVAGE
                                      001918-00-9
                               RABBIT
                              GESTATION    FETUS
                              DAYS 6-18    FETUS

                                           FETUS
                                           DAM
                                                           DECREASED WEIGHT
                                                           INCREASED POST-IMPLANTATION
                                                           LOSSES
                                                           INCREASED MORTALITY
                                                           DECREASED WEIGHT GAIN
3E-2
100
            SUBCHRONIC [RfO] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC  ORAL [RfD].


DICHLOROBENZENE.  1.2-             000095-50-1

                   COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC
                                                                                                                          IRIS
IRIS
                                010854
                                005622


                                010892
          010945
                                                                                                                                   o,o»«
   . a. -

                                                                                                                                             1-35

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
 CHEMICAL     DOSE           SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
(mg/cu m)  (ma/ka/day)   (ma/cu m)  (ma/kQ/dav)
   UF         UF           UF         UF
 DICHLOROBENZENE.  1.3-             000541-73-1

            CHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (06/23/92)  BY  THE RfD/RfC WORK GROUP.
                                                                                                       005414
 DICHLOROBENZENE.  1.4-
     NOAEL 75 MG/CU M
              INHALATION:
              INTERMITTENT
       000106-46-7
 RAT
MULTI-GENERA  LIVER
TION
 INCREASED WEIGHT  IN MALE         2.5E+0
 PARENTS                         30
                       IRIS
             SUBCHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION RfC WAS MODIFIED TO ESTIMATE THE SUBCHRONIC INHALATION [RfC].
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                           010840
 DICHLOROBUTENES
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                        005415
 DICHLOROOIFLUOROMETHANE

     NOAEL 90 MG/KG/DAY
              ORAL:  DIET
        000075-71-8
 DOG
90 DAYS
 NONE OBSERVED
            9E-1
            100
                                                                                             IRIS
                                                                           005498

                                                                           005496
             SUBCHRONIC  [RfC] COMMENT-  ALSO SEE HEAST TABLE  2: ALTERNATE METHODS --  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
             CHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                 1-36

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)                May 1995

 CHEMICAL     DOSE          SPFCTFS                                                               Subchronic         Chronic
 L«L       ROUTE    »«&„       T«ET        CRITICAL EFFKT               ,^.,  ,ja..,    "P.,  JMJ..,  "«E
                                                                                        UF        UF          UF        UF
 DICHLOROETHANE,  1.1-             000075-34-3
      NOEL  115 MG/KG/DAY       RAT

              i™*!      13"E£KS                     ™EoesERvED                            j»                 £j      ««
                      EESi              s                           THOOS"  S"BCHROI"C" CHM"C TOXICITV  (OTHER
                         r£S!:  A!^™SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER
                         LUMMtNT.  BASED ON ROUTE TO ROUTE EXTRAPOLATION
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.


 DICHLOROETHANE. 1.2-             000107-06-2

            S5SSS rolm r^ENT:  C°NTACT ™E SUPERFUND HEAL™ RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
            XoTrL£f?] COmENT:  C°NTACT ™E SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300'
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.


 DICHLOROETHYLENE.  1.1-           000075-35-4
     LOAEL 9 MG/KG/DAY          RAT
             ORALR DRINKING    2 YEARS       LIVER           LESIONS                                 9E.3                IRIS       005419
             MAItR                                                                               1000

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED  AS THE SUBCHRONIC ORAL [RfD]
            CHRONIC [RfD]  COMMENT:  UNDER REVIEW.  CURRENT NUMBER SUBJECT TO CHANGE
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                       1-37

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                               May 1995
CHEMICAL    pjfit          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic
  [RfC]      [RfD]
(M/CU m)  (ma/kQ/dav)
   UF        UF
      Chronic
 [RfC]        [RfD]     REFERENCE
(mQ/cu m)  (ina/ko/dav)
   UF        UF
DICHLOROETHYLENE. 1.2-  (MIXED ISOMERS)    000540-59-0
     LOAEL 50 PPM               RAT
             ORAL:  DRINKING    2 YEARS      LIVER           LESIONS
             WATER
                                                         9E-3
                                                         1000
                                                                9E-3
                                                                1000
                                                                                        .010509
            SUBCHRONIC [RfD] COMMENT:  VALUES DERIVED FOR 1.1-DICHLOROETHYLENE  WERE ADOPTED FOR 1.2-  DICHLOROETHYLENE MIXED  ISOMERS

            CHRONIC [RfD]  COMMENT:  VALUES DERJVED FOR 1.1-DICHLOROETHYLENE (000075-35-4) WERE ADOPTED  FOR 1.2-DICHLOROETHYLENE MIXED
                              ISOMERS BASED ON ANALOGY.
DICHLOROETHYLENE.  1.2-C-          000156-59-2
     NOAEL 32 MG/KG/DAY         RAT
             ORAL: GAVAGE      90 DAYS       BLOOD
                                            BLOOD
                DECREASED HEMATOCRIT
                DECREASED HEMOGLOBIN
                                           1E-1
                                           300
                                 1E-2
                                 3000
                                                                                         005420
            C41RONIC [RfD] COMMENT:  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
 DICHLOROETHYLENE.  1.2-T-          000156-60-5
     NOAEL 17 MG/KG/DAY         MOUSE
              ORAL: DRINKING    90 DAYS       BLOOD
              WATER
                INCREASED ALKALINE PHOSPHATASE
                                           2E-1
                                           100
                                                                               IRIS
                                                                           005895
 DICHLOROPHENOL. 2.3-              000576-24-9
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                         005315
 IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                1-38

-------
                                 HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                     May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
      TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]        [RfC]       [RfD]    REFERENCE
(mq/cu m)  (mg/kq/dav)   (fia/cu m) (ma/ka/dav)
   UF         UF          UF        UF
DICHLORQPHENOL.  2.4-
     NOEL  3 PPM                RAT
             ORAL:  DRINKING    2
             WATER            GENERATIONS
000120-83-2

      IMMUNE  SYSTEM
 ALTERED  IMMUNE FUNCTION
           3E-3
           100'
            SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            CHRONIC [RfD] COMMENT:  BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES BEFORE AND DURING GESTATION.
                             PARTURITION. AND WEANING OF PUPS.
IRIS
005314
DICHLOROPHENOL.  2.5-              000583-78-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                              005316
DICHLOROPHENOL.  2.6-              000087-65-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                              005317
DICHLOROPHENOL.  3.4-              000095-77-2
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                              005318
DICHLOROPHENOL.  3.5-              000591-35-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                              005319
DICHLOROPHENOXY ACETIC ACID.  2.4-    000094-75-7
     NOAEL  1 MG/KG/DAY          RAT
             ORAL: DIET        91 DAYS      BLOOD           TOXICITY
                                           LIVER           TOXICITY
                                           KIDNEY          TOXICITY

            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
                                                                1E-2
                                                                100
                                                                IRIS
                                           010265
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                         1-39

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                           May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH      TARGET
                            CRITICAL EFFECT
DICHLOROPHENOXY)  BUTYRIC ACID.  4-(2.4-  / (2.4-DB)     000094-82-6
     NOAEL 8 MG/KG/DAY         DOG
             ORAL: DIET        90 DAYS       CARDIOVASCULAR   HEMORRHAGE
                                           SYSTEM
                                           WHOLE BODY       INCREASED MORTALITY
                                                                                      Subchronic          Chronic
                                                                              [RfC]     [RfD]       [RfC]        [RfD]     REFERENCE
                                                                             (ma/cu m) (ma/ka/dav)   (ITO/CU m)  (ma/kQ/dav)
                                                                               UF         UF          UF         UF
                                                                      8E-2
                                                                      100
                                                                                                             IRIS       005890
DICHLOROPROPANE,  1.1-             000078-99-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
DICHLOROPROPANE.  1.2-
     NQAEL 69.3 MG/CU
             INHALATION:
             INTERMITTENT
       000078-87-5
 RAT
13  WEEKS
                               NASAL MUCOSA     HYPERPLASIA


GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1.3E-2
100
IRIS
                                                                                                     005897
005898
DICHLOROPROPANE.  1.3-             000142-28-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                     005899
DICHLOROPROPANE.  2.2-             000594-20-7
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                     005900
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                               1-40

-------
                                   HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY)
                                                                                                              May 1995
 CHEMICAL     J2QSE           SPECIES
 LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
 DICHLOROPROPENE.  1.3-  /  (TELONE  II)
      NOEL  3 MG/KG/DAY          RAT
              ORAL:  DIET        90 DAYS       ORGANS
      CRITICAL EFFECT


000542-75-6

       INCREASED WEIGHT
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
     NOAEL 5 PPM                MOUSE
              INHALATION:       2 YEARS
              INTERMITTENT
             NASAL MUCOSA     HYPERTROPHY
             NASAL MUCOSA     HYPERPLASIA
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]    REFERENCE
(mq/cu m)  (mg/kq/dav)   (mg/cu m)  (mQ/ka/dav)
   UF          UF           UF        UF
                                                                                                        3E-3
                                                                                                        1000
                                       2E-2
                                       30
             SUBCHRONIC [RfC] COMMENT:   THE  CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION  [RfC].
                      IRIS
                                                                                             IRIS
                                                                                  005901
010351
DICHLORPROP                         000120-36-5
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                       005896
DICYCLOPENTADIENE
     NOEL  32 MG/KG/DAY
             ORAL: DIET
       000077-73-6
RAT
                               GENERATIONS
                                                             NONE  OBSERVED
                                                                        3E-1
                                                                        100
                                                                       3E-2
                                                                       1000
                                                                                                                                       005425
            SUBCHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            SUBCHRONIC [RfD] COMMENT:  BASED ON A 3-GENERATION  REPRODUCTION STUDY.
            CHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfD] COMMENT:   BASED ON A 3-GENERATION REPRODUCTION STUDY.
DIELDRIN                             000060-57-1
     NOAEL  0.005 MG/KG/DAY      RAT
             ORAL: DIET        2  YEARS       LIVER
                             LESIONS
                                                                                                       5E-5
                                                                                                       100
                                                                                             IRIS
                                                                                 005429
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD  WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-41

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                           May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
             TARGET
CRITICAL EFFECT
         Subchronic          Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mg/cu m) (ma/kg/dav)  (mo/cu m) (mg/kg/davJ
   UF         UF          UF        UF
DIETHYL PHTHALATE
     NOAEL 750 MG/KG/DAY
             ORAL: DIET
       000084-66-2
RAT
16 WEEKS      WHOLE BODY
             ORGANS
 DECREASED GROWTH
 DECREASED WEIGHT
           8E+0
           100
IRIS
                                                                         005620
DIETHYL-P-NITROPHENYL  PHOSPHATE           000311-45-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                    005922
DIETHYLANILINE.  N.N-              000091-66-7
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                     005903
DIETHYLENE GLYCOL MONOBUTYL  ETHER     000112-34-5
     NOAEL  18 PPM               RAT
                                                           NONE OBSERVED
                                                            2E-1
                                                            100
                                                     2E-2
                                                     1000
                                                                                                                                   005482
            CHRONIC [RfC] COMMENT:   UNDER REVIEW.
DIETHYLENE GLYCOL MONOETHYL  ETHER    000111-90-0
     NOEL  200 MG/KG/DAY        RAT
             ORAL:  DRINKING                 KIDNEY           HISTOPATHOLOGY
             WATER

            CHRONIC [RfD] COMMENT:  BASED ON A 3-GENERATION REPRODUCTION STUDY.
     NOEL  500 MG/KG/DAY        RAT
             ORAL:  DIET       90 DAYS
             KIDNEY
             TESTIS
 IMPAIRED FUNCTION
 INCREASED WEIGHT
            5E+0
            100
                                                                                           2E+0
                                                                                           100
                                                                          005478
                                                                                                     005476
MS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                1-42

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu m)  (ma/kQ/dav)   (mg/cu m)  (ma/ka/dav)
   UF         UF           UF         UF
DIETHYLFORMAMIDE                   000617-84-5
     NOEL  0.546 MG/DAY. 5 DAYS/WEEK          RAT
             ORAL: GAVAGE      73 WEEKS
                             NONE OBSERVED
                                                                                                     1.1E-2
                                                                                                     100
                                                                               LIE-2     010437
                                                                               100
DIETHYLHYDRAZINE. 1.2-            001615-80-1
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.  ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
                                                                                                       005921
DIMETHOATE                          000060-51-5
     NOEL  0.05 MG/KG/DAY       RAT
             ORAL: DIET       2 YEARS      BRAIN
                             DECREASED CHOLINESTERASE
                             ACTIVITY
            SUBCHRONIC [RfD] COMMENT:   THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                          2E-4
                                                          300
                                 IRIS       005923
DIMETHYLANILINE.  N.N-
     LOAEL 22.32 MG/KG/DAY
             ORAL:  GAVAGE
       000121-69-7
MOUSE
13 WEEKS
SPLEEN
                                                            EFFECTS
            2E-2
            1000
                                                                                            IRIS       005924
DIMETHYLFORMAMIDE. N.N-          000068-12-2
     NOAEL 96 MG/KG/DAY         RAT
             ORAL:  DIET        119 DAYS      LIVER
     LOAEL  22 MG/CU M
             INHALATION:
             INTERMITTENT
HUMAN
                             EFFECTS
             LIVER           EFFECTS
             GASTRO          EFFECTS
             INTESTINAL SYSTEM
                                               3E-2
                                               300
                                                          1E+0
                                                          100
            SUBCHRONIC  [RfC] COMMENT:   THE CHRONIC INHALATION RFC WAS ADOPTED AS  THE SUBCHRONIC INHALATION [RFC].
                      IRIS
                                                                                                                           1E-1
                                                                                                                           1000
                                           005925
010352
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-43

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                [RfC]
                              (mg/cu m)
                                 UF
Subchronic
   [RfO]
dnq/kq/dav)
    UF
      Chronic
 [RfC]        [RfD]
(na/cu m)  (ma/kg/dav)
   UF         UF
                                                                                                                                      REFERENCE
DIMETHYLPHENOL.  2.3-              000526-75-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005926
DIMETHYLPHENOL.  2.4-              000105-67-9
     NOAEL  50 MG/KG/DAY         MOUSE
             ORAL:  GAVAGE      90 DAYS
             NERVOUS SYSTEM   EFFECTS
             BLOOD           ALTERATIONS
                                                          2E-1
                                                          300
                                                                                            IRIS
                                                                                         010266
DIMETHYLPHENOL.  2.5-              000095-87-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                      005928
DIMETHYLPHENOL.  2.6-
     NOEL  0.6 MG/KG/DAY
             ORAL
       000576-26-1
 RAT
8 MONTHS
WHOLE BODY
ORGANS.  MAJOR
INCREASED WEIGHT
LESIONS
  6E-3
  100
                                                                               IRIS
                                                                         005431
DIMETHYLPHENOL.  3.4-
     NOEL  1.4 MG/KG/DAY
             ORAL
       000095-65-8
 RAT
8 MONTHS
WHOLE BODY
ORGANS.  MAJOR
CARDIOVASCULAR
SYSTEM
DECREASED WEIGHT
LESIONS
ALTERED BLOOD PRESSURE
  1E-2
  100
                                                                               IRIS
                                                                         005437
DIMETHYLPHTHALATE                  000131-11-3
            CHRONIC RfD COMMENT-  THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (02/16/94) BY THE RfD/RfC WORK GROUP.
                                                                                                               IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC  IS CONSIDERED NOT VERIFIABLE (07/26/90) BY THE RfD/RfC WORK GROUP.
                                                                                                      010267
                                                                                                      010894
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                1-44

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
 CHEMICAL     QQSI          SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL EFFECT
                                                                     Subchronic          Chronic
                                                             [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                                           (mg/cu m) (mq/kq/dav)   (mq/cu m)  (mq/kq/dav)
                                                              UF         UF          UF        UF
 DIMETHYLTEREPHTHAUTE             000120-61-6
     LOAEL 125 MG/KG/DAY        RAT
              ORAL: DIET       103 WEEKS    KIDNEY           INFLAMMATION


            SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
                                                                       1E-1
                                                                       1000
                                                                               IRIS       005930
DIMETHYLUREA.  N.N-                 000598-94-7
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                   005931
DINITRO-0-CRESOL. 4.6-           000534-52-1
            CHRONIC [RfC]  COMMENT:  THE  CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE  (02/11/93) BY THE RfD/RfC WORK GROUP.        010470

DINITRO-P-CRESOL. 2.6-           000609-93-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT                                                         005934
DINITROBENZENE.  1.2-
     NOAEL  0.4 MG/KG/DAY
             ORAL:  DRINKING
             WATER
       000528-29-0
RAT
16 WEEKS
SPLEEN
                             INCREASED WEIGHT
            SUBCHRONIC  [RfD] COMMENT:   DERIVED BY ANALOGY TO 1.3-DINITROBENZENE
            CHRONIC [RfD] COMMENT:   DERIVED BY ANALOGY TO 1.3-DINITROBENZENE.
                                                                       4E-3
                                                                       100
                                                                               4E-4
                                                                               1000
010201
DINITROBENZENE.  1.3-
     NOAEL 0.4 MG/KG/DAY
             ORAL:  DRINKING
             WATER
RAT
       000099-65-0
             SPLEEN
                INCREASED WEIGHT
                                                                       1E-3
                                                                       100
                                                                               IRIS
010471
IRIS. EPA-S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                1-45

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL    DOSE          Sf£CJ£S
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL  EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
                              (IDQ/CU m)  (ma/ko/dav)   (ITM/CU m)  (mg/ka/dav)
                                 UF         UF          UF         UF
DINITROBENZENE.  1.4-
     NOAEL 0.4 MG/KG/OAY
             ORAL:  DRINKING
             WATER
       000100-25-4
RAT   -
16 WEEKS
SPLEEN
INCREASED WEIGHT
            SUBCHRONIC [RfD] COMMENT:  DERIVED BY ANALOGY TO 1.3-DINITROBENZENE.
            CHRONIC [RfD] COMMENT:  DERIVED BY ANALOGY TO 1.3-DINITROBENZENE.
4E-3
100
4E-4       010202
1000
DINITROPHENOL.  2.3-               000066-56-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005936
DINITROPHENOL.  2.4-
     LOAEL 2 MG/KG/DAY
             ORAL
 HUMAN
       000051-28-5
             EYE
                CATARACT
                                          2E-3
                                          1000
            SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
                                                                                            IRIS
                                                                                                                IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (06/13/91) BY THE RfD/RfC WORK GROUP.
                                                                                         010438
                                                                                                      010895
DINITROPHENOL.  2.5-               000329-71-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DINITROPHENOL.  2.6-               000573-56-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005937
                                                                                                     005938
DINITROPHENOL.  3.5-               000586-11-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005939
DINITROTOLUENE.  2.3-               000602-01-7
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005940
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-46

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
               TARGET
               CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfO]       [RfC]        [RfD]     REFERENCE
(ITO/CU m)  (ma/ka/dav)   (tna/cu m)  (ina/ka/dav)
   UF         UF           UF        UF
DINITROTOLUENE.  2.4-
     NOAEL  0.2 MG/KG/DAY        DOG
             ORAL:  GELATIN    UP TO 2
             CAPSULE          YEARS
        000121-14-2
              CENTRAL NERVOUS  NEUROTOXICITY
              SYSTEM
              ERYTHROCYTES    HEINZ BODIES
              BILIARY TRACT   HYPERPLASIA
                                                          2E-3
                                                          100
                                 IRIS
                                                                                                         005941
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD IS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                                 IRIS
                                                                                                         010896
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED  NOT VERIFIABLE (12/20/90)  BY THE RfD/RfC WORK GROUP.
DINITROTOLUENE.  2.5-
            GENERAL COMMENT:
        000619-15-8
DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                          005942
DINITROTOLUENE.  2.6-
     NOAEL 4 MG/KG/DAY
             ORAL:  DIET
        000606-20-2
  GOG
 13 WEEKS
WHOLE BODY      MORTALITY
CENTRAL NERVOUS  NEUROTOXICITY
SYSTEM
BLOOD
BLOOD
BILE DUCT
KIDNEY
                                                            HEINZ BODIES
                                                            METHEMOGLOBINEMIA
                                                            HYPERPLASIA
                                                            HISTOPATHOLOGY
            CHRONIC [RfD] COMMENT:  UNDER REVIEW.  CURRENT NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DINITROTOLUENE.  3.4-
            GENERAL COMMENT:
        000610-39-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
            IE-2
            300
1E-3
3000
005943
                                                                                          005944
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                    1-47

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                              (mg/cu m) (mg/kq/dav)   (mo/cu m) (mg/ka/dav)
                                 UF         UF          UF         UF
DINOSEB
     LOAEL 1 MG/KG/DAY
             ORAL:  DIET
       000088-85-7
 RAT
29 WEEKS
FETUS
DECREASED WEIGHT
1E-3
1000
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RFD WAS ADOPTED AS THE SUBCHRONIC ORAL [RFD].
            CHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RFD WAS DETERMINED FROM A 3-GENERATION REPRODUCTION STUDY.
DIPHENYLAHINE.  N.N-
     NOEL  2.5 MG/KG/DAY        DOG
             ORAL: DIET       2 YEARS
       000122-39-4

             WHOLE BODY
             LIVER
             KIDMEY
                DECREASED WEIGHT GAIN
                INCREASED WEIGHT
                INCREASED WEIGHT
                                          2.5E-2
                                          100
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS
                     IRIS
005945
          005946
DIRECT LIGHTFAST BLUE             004399-55-7
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                       005947
DISULFOTON
     LOAEL  0.04 MG/KG/DAY       RAT
             ORAL:  DIET       2 YEARS
       000298-04-4

             EYE
             BLOOD
                DEGENERATION
                CHOLINESTERASE  INHIBITION
                                          4E-5
                                          1000
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                     IRIS
          010412
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK. INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                  1-48

-------
                                  HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN  CARCINOGENICITY)                  May 1995

                                                                                                     Subchronic           Chronic
CHEMICAL    DOSE           SPECIES                                                            [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
LEVEL       ROUTE     EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT                 (ma/cu m)  (mg/kq/dav)   (ma/cu m) (ma/ka/day)
                                                                                              UF         UF          UF         UF

ENDOSULFAN                          000115-29-7
     NOAEL 15  PPM               RAT
             ORAL: DIET        2 YEARS       WHOLE BODY       DECREASED WEIGHT GAIN                      6E-3                 IRIS       010926
                                            KIDNEY          GLOMERULONEPHROSIS                         100
                                            BLOOD VESSEL     ANEURYSMS

     NOAEL 10  PPM               DOG
             ORAL: DIET        1 YEAR        WHOLE BODY       DECREASED WEIGHT GAIN                                                      010938

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHORNIC ORAL [RfD]  BASED ON CO-CRITICAL  RAT AND DOG
                                      STUDIES.

ENDOTHALL                           000145-73-3
     NOEL  2 MG/KG/DAY          DOG
             ORAL: DIET        2 YEARS       STOMACH         INCREASED WEIGHT                           2E-2                 IRIS       005948
                                            SMALL INTESTINE  INCREASED WEIGHT                           100

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].


ENDRIN                               000072-20-8
     NOEL  0.025 MG/KG/DAY      DOG
             ORAL: DIET        2 YEARS       CENTRAL NERVOUS  CONVULSIONS                                3E-4                 IRIS       005445
                                            SYSTEM                                                     100
                                            LIVER           LESIONS

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.                    1-49

-------
                                   HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
 Cjj£MJ£Ai    DOSE          SPECIES
 LEVEL       ROUTE     EXPERIMENT LENGTH
               TARGET
 EPICHLOROHYDRIN
      LOAEL  37.8 MG/CU M
              INHALATION:
              INTERMITTENT
        000106-89-8
 RAT
 136 WEEKS     KIDNEY
                                                            CRITICAL EFFECT
LESIONS
                                         Subchronic          Chronic
                                 [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
                               (TO/CU m)  (mg/kg/dav)   (mg/cu m)  (mg/kg/dav)
                                 UF         UF           UF         UF
                                                                        2E-3
                                                                        1000
                                                                2E-3       010440
                                                                1000
             SUBCHRONIC  [RfD] COMMENT:  BASED ON ROUTE-TO-ROUTE EXTRAPOLATION. THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD]
             CHRONIC [RfD] COMMENT:  WITHDRAWN FROM  IRIS (04/01/92)
             GENERAL COMMENT:  ALSO SEE HEAST TABLE  3: CARCINOGENICITY
     NOAEL 19 MG/CU M           RAT
              INHALATION:       90 DAYS      NASAL
              INTERMITTENT                   EPITHELIUM
                              LESIONS
                                                              1E-2
                                                              100
                                                     IRIS
                                                                          010492
 EPTC
     NOEL  2.5 MG/KG/DAY
              ORAL: DIET
        000759-94-4
 RAT
2            HEART
GENERATIONS
                                                             DEGENERATIVE CARDIOMYOPATHY
                                          2.5E-2
                                          100
             SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
             CHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RFD WAS DETERMINED FROM A 2-GENERATION REPRODUCTION STUDY.
                                                                                                                            IRIS
005959
ETHOPROP                            013194-48-4
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                      005951
ETHOXYETHANOL  ACETATE, 2-
       000111-15-9
                                                                                                                                      010507
            SUBCHRONIC [RfD]  COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS  --  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ETHOXYETHANOL ACRYLATE, 2-        000106-74-1
            GENERAL COMMENT:  DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                     005953
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE   (513) 569-7254.
                                                                                                                  1-50

-------
                                 HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
                                              CRITICAL EFFECT
ETHOXYETHANOL DODECANOATE.  2-    000106-13-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
          Subchronic          Chronic
  [RfC]      [RfD]        [RfC]       [RfD]    REFERENCE
(mq/cu m)  (na/ka/dav)   (mo/cii m) (ma/kg/dav)
   UF         UF          UF         UF
                                                                                                     005956
ETHOXYETHANOL PHOSPHATE. 2-      068554-00-7
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005955
ETHOXYETHANOL.  2-                 000110-80-5
     LQAEL  357 MG/KG/DAY        RAT
             ORAL: GAVAGE      103 WEEKS     WHOLE BODY
     NOEL   50 uL/KG/DAY         RAT
             ORAL:  GAVAGE      21 DAYS
                             DECREASED WEIGHT
                                                                       5E-1
                                                                       100
                               FETUS           SKELETAL MALFORMATIONS


SUBCHRONIC  [RfD] COMMENT:   BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS  1-21 OF GESTATION.
                                                                                                              4E-1
                                                                                                              1000
                                           005470
                                           005468
     NOAEL  380 MG/CU M          RABBIT
             INHALATION:       13 WEEKS
             INTERMITTENT
             BLOOD
                                               ALTERED HEMATOLOGY
 2E+0
 30
IRIS
010441
ETHOXYETHYL METHACRYLATE. 2-     002370-63-0
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005954
ETHYL ACETATE
     NOEL  900 MG/KG/DAY
             ORAL: GAVAGE
       000141-78-6
 RAT
90 DAYS      WHOLE BODY
             WHOLE BODY
                                               INCREASED MORTALITY
                                               DECREASED WEIGHT
            9E+0
            100
           IRIS
005957
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-51

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGEN1CITY)
                                                                                                              May  1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                              (mg/cu m) (mq/ka/dav)   (mq/cu m) (tng/kg/dav)
                                 UF         UF          UF         UF
ETHYL BENZENE
       000100-41-4
                                                                                                                 IRIS
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE  SUPERFUNO HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE  SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
ETHYL CHLORIDE
     NOAEL 1504 PPM
             INHALATION:
             INTERMITTENT
       000075-00-3
MOUSE
10 DAYS
FETUS
DEVELOPMENTAL TOXICITY
1E+1
300
            SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
            CHRONIC [RfC]  COMMENT:  BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
                                                                     IRIS
                                                                                                                            IRIS
                                                                                                       010867
                                                                                                       010866
                                                                          010371
ETHYL ETHER                         000060-29-7
     NOAEL 500 MG/KG/DAY        RAT
             ORAL: GAVAGE      90 DAYS       LIVER
                              EFFECTS
                                                          2E+0
                                                          300
                                                                                             IRIS
                                                                          010396
ETHYL METHACRYLATE                 000097-63-2
     NOEL  7.5 MG/KG/DAY        RAT
             ORAL: DRINKING    2 YEARS       KIDNEY
             WATER
                              INCREASED RELATIVE WEIGHT
                                                          9E-2
                                                          100
                                                               9E-2
                                                               100
                                          005961
            CHRONIC [RfD] COMMENT:  CALCULATED FROM METHYL METHACRYLATE DATA BY MULTIPLYING BY THE RATIO OF THE MOLECULAR WEIGHTS  (114.5/100.13).
ETHYL-0-XYLENE.  4-                 000934-80-5
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                        010472
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-52

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                               May 1995
 CHEMICAL     BQSt          SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(roa/cu m)  (ma/ka/dav)   (mg/cu m)  (ma/kQ/dav)

ETHYLANILINE. N-
GENERAL COMMENT:
ETHYLENE CYANOHYDRIN
NOEL 30 MG/KG/OAY
ORAL: DRINKING
WATER
ETHYLENE DIAHINE
NOAEL 22.6 MG/KG/OAY
ORAL: DIET

000103-69-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
000109-78-4
RAT
90 DAYS HEART DECREASED WEIGHT
BRAIN DECREASED WEIGHT
000107-15-3
RAT
3 MONTHS HEART DECREASED WEIGHT
BLOOD HEMATOLOGIC CHANGES
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE
ETHYLENE 6LYCOL
NOEL 200 MG/KG/DAY
ORAL: DIET
000107-21-1
RAT
FETUS FETOTOXICITY
UF UF UF UF

3E-1 3E-1
100 100
2E-1 2E-2
100 1000
IRIS
(12/18/90) BY THE RfD/RfC WORK GROUP.
IRIS
2E+0
100

005958
005780
005796
010898
005454
005452
            SUBCHRONIC [RfD] COMMENT:  BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
ETHYLENE  GLYCOL MONOBUTYL  ETHER      000111-76-2
     NOAEL  121 MG/CU M          RAT
             INHALATION:        13 WEEKS     BLOOD
             INTERMITTENT
               ALTERED HEMATOLOGY
                                2E-1
                                100
                      2E-2
                      1000
            CHRONIC [RfC] COMMENT:  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
010353
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE': (513) 569-7254.
                                                                                                    1-53

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                      May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET
                     CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]        [RfC]        [RfD]     REFERENCE
                               (mQ/cu m) (mo/kg/dav)   (na/cu m) (ma/kq/dav)
                                 UF         UF          UF         UF
ETHYLENE THIOUREA                  000096-45-7
     LOAEL 0.25 MG/KG/DAY       RAT
             ORAL:  DIET        24 MONTHS    THYROID
                      HYPERPLASIA
                                          8E-5
                                          3000
                     IRIS       010397
            SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

            CHRONIC [RfC] COMMENT:  THE CHRONIC  INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (08/12/92) BY THE  RfD/RfC WORK GROUP
                                                                                                010899
ETHYLTOLUENE. M-                    000620-14-4
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                               005963
ETHYLTOLUENE. 0-                    000611-14-3
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                               005962
ETHYLTOLUENE. P-                    000622-96-8
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                               005964
FLUORANTHENE
     NOAEL  125 MG/KG/DAY        MOUSE
             ORAL:  GAVAGE      90 DAYS
000206-44-0

      KIDNEY
      LIVER
      BLOOD
NEPHROPATHY
WEIGHT CHANGES
HEMATOLOGICAL CHANGES
4E-1
300
IRIS
            CHRONIC [RfC] COMMENT:  THE CHRONIC  INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP.
010168
                                                                                                010967
FLUORENE                             000086-73-7
     NOAEL 125 MG/KG/DAY        MOUSE
             ORAL:  GAVAGE      13 WEEKS      ERYTHROCYTES     DECREASED COUNTS
                                                                4E-1
                                                                300
                                                                IRIS
                                010169
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                          1-54

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                      May 1995
£HQ1I£A1     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
       TARGET
FLUORINE / (SOLUBLE  FLUORIDE)     007782-41-4
     NOAEL 0.06 MG/KG/DAY       HUMAN
             ORAL: DRINKING                 TOOTH
             WATER
CRITICAL EFFECT
                      FLUOROSIS
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(ma/cu m)  (mg/ka/dav)   (im/cu m)  (iro/kg/dav)
   UF        UF           UF         UF
                                           6E-2
                                           1
                                 IRIS
005965
FLURIDONE
     NOEL  200 PPM              RAT
             ORAL:  DIET       2 YEARS
059756-60-4

      KIDNEY
      TESTIS
      WHOLE BODY
      ORGANS
 GLOMERULONEPHRITIS
 ATROPHY
 DECREASED WEIGHT
 DECREASED WEIGHT
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
FOLPET
     NOEL  10 MG/KG/DAY         DOG
             ORAL: CAPSULE     1 YEAR
000133-07-3

      WHOLE BODY
      BLOOD
 ALTERED WEIGHT GAIN
 ALTERED CHEMISTRY
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
FORMALDEHYDE
     NOAEL  15 MG/KG/DAY         RAT
             ORAL:  WATER      2 YEARS
000050-00-0
      GASTRO-          LESIONS
      INTESTINAL TRACT
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      8E-2
                                                                                                      100
                                                                                                      1E-1
                                                                                                      100
                                                                                                      2E-1
                                                                                                      100
                                 IRIS
                                 IRIS
                                                                IRIS
005966
005967
                                           010398
FORMALDEHYDE CYANOHYDRIN          000107-16-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                               005782
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                          1-55

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                               May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT  LENGTH
              TARGET
                CRITICAL EFFECT
                                                               [RfC]
                                                         Subchronic
                                                            [RfD]
                                                            Chronic
                                                       [RfC]        [RfD]
                                            REFERENCE
                               (mg/cu m)  (mg/kg/dav)   (mg/cu m)  (mg/ka/dav)
                                  UF         UF           UF        UF
FORMIC ACID
     NOAEL 200 MG/KG/DAY
             ORAL: WATER
        000064-18-6
 RAT
MULTI-
GENERATION
WHOLE BODY
DECREASED GROWTH
           2E+0
           100
            CHRONIC [RfD] COMMENT:   BASED ON A MULTI-GENERATION  STUDY. WITHDRAWN FROM IRIS (12/01/90). UNDER REVIEW.
                             CURRENT NUMBER SUBJECT TO CHANGE.
                     2E+0
                     100
                     010268
FURAN
     NOAEL 1.4 MG/KG/DAY
             ORAL: GAVAGE
        000110-00-9
 MOUSE
13 WEEKS
LIVER
LESIONS
           1E-2
           100
                      IRIS
                     005462
FURFURAL
     LOAEL 7.9 MG/KG/DAY
             ORAL: GAVAGE
        000098-01-1
 RAT
13 WEEKS
LIVER
HEPATOTOXICITY
           3E-2
           300
                      IRIS
                     005466
            SUBCHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
            CHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
GLYCIDALDEHYDE
     NOAEL 29 MG/CU M
              INHALATION:
              INTERMITTENT
        000765-34-4
 RAT
12 WEEKS
WHOLE BODY
KIDNEY
DECREASED WEIGHT
EFFECTS
1E-2
300
4E-3
300
            SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE  EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5
            CHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION  FACTOR OF 0 5.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1E-3
3000
IRIS
005968
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                   1-56

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET
                             CRITICAL EFFECT
                                                        Subchronlc          Chronic
                                                 [RfC]      [RfD]        [RfC]       [RfD]     REFERENCE
                                               (mg/cii m) (mg/kg/dav)   (ma/cu m)  (iro/kg/day)
                                                 UF         UF          UF         UF
HEPTACHLOR                          000076-44-8
     NOEL  0.15 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS       LIVER
                              INCREASED WEIGHT
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY
HEPTACHLOR EPOXIDE                 001024-57-3
     LOAEL 0.0125 MG/KG/DAY     DOG
             ORAL:  DIET        60 WEEKS      LIVER
                              INCREASED RELATIVE WEIGHT
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                          5E-4
                                                          300
                                                           1.3E-5
                                                           1000
                                                               IRIS       005506
                                                                IRIS
                                010399
HEPTANE.  N-                         000142-82-5
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      005969
HEXABROMOBENZENE
     NOAEL 2 MG/KG/DAY
             ORAL: DIET
       000087-82-1
 RAT
12 WEEKS
LIVER
INDUCED CARBOXYLESTERASE
ACTIVITY
2E-2
100
                                                                                                                            IRIS
005970
HEXACHLOROBENZENE
       000118-74-1
                                                                                                                            IRIS
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED  NOT VERIFIABLE (11/15/90)  BY THE RfD/RfC WORK GROUP.

            SUBCHRONIC [RfC]  COMMENT:  CONTACT THE  SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
                                                                                                       010868
                                                                                                       010900
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                  1-57

-------
                                 HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
(mq/cii m)  (mg/kg/dav)   (ma/cu m)  (mg/kg/dav)
   UF         UF           UF         UF
HEXACHLOROBUTADIENE
     LOAEL 0.5 MG/KG/DAY
             ORAL:  DIET
       000087-68-3
MOUSE
13 WEEKS
RENAL TUBULES    REGENERATION
            CHRONIC  [RfD] COMMENT:  WITHDRAWN FROM IRIS (05/01/93). UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
            SUBCHRONIC [RfD] COMMENT:   CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
                                 2E-4       010927
                                 1000
HEXACHLOROCYCLOHEXANE.  DELTA-   000319-86-8
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      010495
HEXACHLOROCYCLOHEXANE.  EPSRON-     006108-10-7
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                      010496
HEXACHLOROCYCLOHEXANE.  GAMMA-   000058-89-9
     NOAEL 0.33 MG/KG/DAY       RAT
             ORAL:  DIET        12 WEEKS      LIVER
                                           KIDNEY
                             TOXICITY
                             TOXICITY
                                                          3E-3
                                                          100
                                 IRIS
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

            CHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION  [RfC] IS CONSIDERED NOT VERIFIABLE (05/27/92) BY THE RfD/RfC WORK GROUP.
005537
                                                                                                      010903
HEXACHLOROCYCLOPENTADIENE        000077-47-4
     NOAEL 7.1 MG/KG/DAY        RAT
             ORAL             13 WEEKS      FORESTOMACH     LESIONS
                                                                       7E-2
                                                                       100
                                                                               IRIS
     NOAEL 0.15 PPM             RAT
             INHALATION:       13 WEEKS
             INTERMITTENT
             NASAL CAVITY     SQUAMOUS METAPLASIA
                                               7E-4
                                               100
                      7E-5
                      1000
                                           005299
010445
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE  (513) 569-7254
                                                                                                                 1-58

-------
                                   HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                                 May  1995
              BQSI          SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL  EFFECT
 HEXACHLOROETHANE                   000067-72-1
      NOAEL 1  MG/KG/DAY          RAT
              ORAL: DIET       16 WEEKS      KIDNEY           DEGENERATION
                                                                                         Subchronic          Chronic
                                                                                 [RfC]      [RfO]       [RfC]        [RfD]     REFERENCE
                                                                               (mq/cu m)  Imq/kQ/dav)   (mq/cu m)
                                                                                  UF
UF
                                                                                                       1E-2
                                                                                                       100
                                                                                                         UF
                                                                                                                                UF
                                                                                                                IRIS       005518
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

             CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT  VERIFIABLE (11/05/92).  BY THE RfD/RfC WORK GROUP.
 HEXACHLOROPHENE
      LOAEL 0.75 MG/KG/DAY       DOG
              ORAL:  DIET        13 WEEKS
                          000070-30-4
                                NERVOUS SYSTEM   EFFECTS
                                                                                                       3E-3
                                                                                                       300
                                                                                                               IRIS
 HEXAMETHYLENE DIAMINE             000124-09-4
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
 HEXANE.  N-
     LOAEL 570 MG/KG/DAY
             ORAL
                          000110-54-3
     LOAEL 73 MG/CU M
              INHALATION:
              INTERMITTENT
                   RAT
                   HUMAN
                                            NERVOUS SYSTEM   NEUROPATHY
                                            TESTIS           ATROPHY
                               NERVOUS SYSTEM   NEUROTOXICITY


SUBCHRONIC  [RfC] COMMENT:   THE  CHRONIC INHALATION  RfC WAS ADOPTED AS THE  SUBCHRONIC INHALATION [RfC]


2E-1
300
6E-1
1000
IRIS

6E-2
10000


HEXANONE.  2-                        000591-78-6
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                          010904
                             005972
                                                                                                                                     005973
                                                                                                                          005974
                             010273
                                                                                                                                     005976
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                1-59

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH      TARGET
                             CRITICAL EFFECT
                                        Subchronic          Chronic
                                 [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                               (mg/cu m) (ma/kq/dav)   (ma/cu m)  (ma/kq/dav)
                                 UF         UF           UF         UF
HYDROGEN  SULFIDE
     NOAEL  3.1 MG/KG/DAY
             ORAL:  FOOD
       007783-06-4
 PIG
105 DAYS      GASTRO-         DISTURBANCE
             INTESTINAL SYSTEM
     NOAEL 42 MG/CU M           MOUSE
             INHALATION:       13 WEEKS      NASAL MUCOSA     INFLAMMATION
             INTERMITTENT
                                                             9E-3
                                                             100
                                          3E-2
                                          100
                                                     IRIS
                     IRIS       010269
                                010354
HYDROOJJINONE
     NOAEL 4.29 MG/KG/DAY
             ORAL
       000123-31-9
 HUMAN
3-5 MONTHS    BLOOD
HEMATOLOGICAL EFFECTS
4E-1
10
                                                                                                                 IRIS
4E-2
100
            CHRONIC RfC  COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (10/01/90) BY THE RfD/RfC WORK GROUP.
005526


010905
IRON                                 007439-89-6
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ISOBUTYL ALCOHOL
     NOEL  316 MG/KG/DAY        RAT
             ORAL:  GAVAGE      13 WEEKS
       000078-83-1
             NERVOUS SYSTEM  HYPQACTIVITY
             NERVOUS SYSTEM  ATAXIA
                                           3E+0
                                           100
                      IRIS
                                                                                                       005527
           005977
ISOPHORONE                          000078-59-1
     NOEL   150 MG/KG/DAY        DOG
             ORAL:  CAPSULE     90 DAYS       KIDNEY
                             LESIONS
                                           2E+0
                                           100
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                      IRIS
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/15/90) BY THE RfD/RfC WORK GROUP.
           005910
                                                                                                        010906
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE.  (513) 569-7254.
                                                                                                                  1-60

-------
LEVEL
ROUTE
                           fnr^,rr-
                           SPECIES
                      EXPERIMENT LENGTH
                                   HEAST  TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)



                                             TARGET         CRITICAL EFFECT
 ISOPROPALIN
      NOEL  15 MG/KG/DAY         RAT
              ORAL: DIET       90 DAYS
033820-53-0

      BLOOD
      ORGANS.
      UNSPECIFIED
                                                            HEMATOLIGICAL EFFECTS
                                                            ALTERED WEIGHTS
lUIHtK

[RfC]
(ma/cu n
UF
IHAN CARCINO
Subchronic
[RfD]
i) (ma/ka/dav)
UF
GENICITY)
Chronic
[RfC] [RfD]
(ma/cu m) (ma/ka/da1
UF UF
May 1995

REFERENCE
/>

                                                                                          1 5E-1
                                                                                          100
                                                                                                                             IRIS
                                                                                                                                       005978
 LACTONITRILE                        000078-97-7
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                      005783
LEAD                                 007439-92-1

            ruR™IC CRfC] COtt1ENT:   REFER T0 APPENDIX A:  TECHNICAL INFORMATION.  SECTION  V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
            CHRONIC [RfD] COMMENT:   REFER TO IRIS
            GENERAL COMMENT:  ALSO  SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                                                       010447
 LEAD ALKYLS
             CHRONIC  [RfC] COMMENT:  REFER TO APPENDIX A:  TECHNICAL  INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
             CHRONIC  [RfD] COMMENT:  REFER TO IRIS
             GENERAL  COMMENT:  DIMETHYLETHYL LEAD; METHYLTRIETHYL  LEAD; TETRABUTYL LEAD: TETRAETHYL LEAD  TETRAMETHYL LEAD-
                              TETRAPROPYL LEAD: TRIETHYL      LEAD:  TRIMETHYL LEAD: TRIMETHYLETHYL LEAD: TRIPROPYL LEAD
                                                                                                                                       010448
LINURON                              000330-55-2
     LOAEL  0.625 MG/KG/DAY      DOG
             ORAL: DIET       2 YEARS       BLOOD
                                                             HEMATOLOGICAL EFFECTS
                                                                                          2E-3
                                                                                          300
                                                                                                                            IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                                                       005990
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET
                            CRITICAL EFFECT
                                                        Subchronic          Chronic
                                                [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                              (mq/cu m)  (ma/ka/dav)   (mq/cu ml (ma/ka/dav)
                                                 UF         UF           UF        UF
MALATHION                            000121-75-5
     NOEL  0.23 MG/KG/DAY       HUMAN
             ORAL:  CAPSULE     47 DAYS      BLOOD
                             HEMATOLOGICAL EFFECTS
            SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            CHRONIC [RfC] COMMENT:  UNDER REVIEW.
HALE1C ANHYDRIDE                   000108-31-6
     NOAEL  10 MG/KG/DAY         RAT
             ORAL:  DIET       2 YEARS       KIDNEY
                             LESIONS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
MALEIC HYDRAZIDE
     LOAEL  500 MG/KG/DAY
             ORAL:  DIET
       000123-33-1
 RAT
28 MONTHS     KIDNEY
                ALTERED  FUNCTION
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                          2E-2
                                                          10
                                                          1E-1
                                                          100
                                          5E-1
                                          1000
                                                                                            IRIS       005991
                                                                                            IRIS
                                                                               IRIS
                                                                          005992
                                005993
HALONONITRILE
     LOAEL 0.21 MG/KG/DAY
             ORAL: GAVAGE
       000109-77-3
 RAT
120 DAYS
LIVER
SPLEEN
EFFECTS
EFFECTS
2E-4
1000
2E-5       005994
10000
NANCOZEB
     NOEL  2.9 MG/KG/DAY
             ORAL: DIET
       008018-01-7
 RAT
90 WEEKS
THYROID
GOITROGENIC  EFFECTS
3E-2
100
3E-2
100
                                                                                          005995
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                 1-62

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN  CARCINOGENICITY)
 CHEMICAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 MANEB                                012427-38-2
      NOEL  5 MG/KG/DAY          MONKEY
              ORAL:  DIET        6 MONTHS      THYROID
CRITICAL EFFECT
                              INCREASED WEIGHT
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]
(mq/cu m)  (mg/kq/dav)   (TO/CU m) (mq/kg/dav)
   UF         UF           UF         UF
                                                                                                               May 1995


                                                                                                           REFERENCE
                                                                                                        5E-2
                                                                                                        100
                                                                                              IRIS
                                                                            005996
 MANGANESE
     NOAEL 0.005 MG/KG/DAY      HUMAN
              ORAL: DRINKING    CHRONIC
              WATER
        007439-96-5
              CENTRAL NERVOUS  EFFECTS
              SYSTEM
                                            5E-3
                                            1
             SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL WATER RfD WAS ADOPTED AS THE SUBCHRONIC ORAL WATER [RfD]
                              SEE IRIS FOR SPECIFIC DIETARY INFORMATION.
     NOAEL 0.14 MG/KG/DAY       HUMAN
             ORAL: DIET        CHRONIC
             CENTRAL NERVOUS  EFFECTS
             SYSTEM
                                                                                                        1.4E-1
                                                                                                        1
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL FOOD RfD WAS ADOPTED AS THE SUBCHRONIC ORAL FOOD  [RfD]
                              SEE IRIS  FOR SPECIFIC DIETARY INFORMATION.

            SUBCHRONIC [RfC] COMMENT:   A SUBCHRONIC [RfC] HAS NOT BEEN DERIVED FOR MANGANESE.
                                 IRIS
010850
                                                                 IRIS
                                                                                    IRIS
                                            010851
                                                                            010959
HEPHOSFOLAN
     NOEL  0.09 MG/KG/DAY
             ORAL: DIET
       000950-10-7
 RAT
17 WEEKS
                                            LIVER
                                            KIDNEY
                                            BLOOD

                                            ERYTHROCYTES

                                            BRAIN
ALTERED WEIGHT
ALTERED WEIGHT
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
                                                                         9E-4
                                                                         100
                                 9E-5
                                 1000
005997
MS.  EPA-S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                   1-63

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
CHEMICAL    DOSE
LEVEL       ROUTE     EXPERIMENT LENGTH
                                            TARGET
MERCURIC  CHLORIDE
                               RAT
             ORAL: PARENTERAL
                                      007487-94-7
                                            KIDNEY
CRITICAL EFFECT
 AUTOIMMUNE  EFFECTS
                                                                                                     Subchronic           Chronic
                                                                                             [RfC]      [RfD]       [RfC]       [RfD]
                                                                                           (ma/cu m)  (ma/ko/dav)   (mq/cu m)  (mQ/ko/dav)
                                                                                  May 1995


                                                                             REFERENCE
                                                                                              UF
                                                                                                         UF
3E-4
 1000
                                                          UF
                                                                                                                                UF
                                                                                                                            IRIS
MERCURY.  ELEMENTAL
     NOAEL 0.009 MG/CU M
             INHALATION:
             SUBCHRONIC [RfD] COMMENT: THE CHRONIC  ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].

                                     007439-97-6
                               HUMAN
                                            NERVOUS  SYSTEM   NEUROTOXICITY
                                 3E-4
                                 30
            3E-4
            30
            CHRONIC [RfC] COMMENT:  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.

                                      000150-50-5
MERPHOS
     NOEL   0.1 MG/KG/DAY        HEN
             ORAL: CAPSULE     3  MONTHS
                                            NERVOUS SYSTEM  ATAXIA
                                            NERVOUS SYSTEM  DELAYED NEUROTOXICITY
                                            WHOLE BODY      DECREASED WEIGHT
                                            3E-4
                                            300
                                                                                                                             IRIS
             CHRONIC [RfC] COMMENT:   THE  CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP.
             SUBCHRONIC [RfD] CPMMENT:  THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
MERPHOS OXIDE                      000078-48-8
     NOEL  0.1 MG/KG/DAY        HEN
              ORAL: CAPSULE     3 MONTHS
                                            NERVOUS SYSTEM   ATAXIA
                                            NERVOUS SYSTEM   DELAYED NEUROTOXICITY
                                            WHOLE BODY      DECREASED WEIGHT
                                            3E-4
                                            300
                                                                                                                             IRIS
             CHRONIC  [RfC] COMMENT-  THE CHRONIC  INHALATION [RfC] IS  CONSIDERED NOT VERIFIABLE (06/25/92)  BY THE RfD/RfC WORK GROUP.
             SUBCHRONIC [RfO] CPMMENT:  THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL  [RfD].
                                                                                                                                      005800
                                                                                                                                       010270
                                 005998
                                                                                                                                       010907
                                 005999
                                                                                                                                        010908
 IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                  1-64

-------
                                   HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)                  May 1995

 PHFMirAi     IYKC           cornrc                                                                    Subchronic          Chronic
 InbflllAl.    ELSE.           SPECIES                                                            rRfc-i      rRfD-|       rRfC1        rRfm     RFFFRFNCT
 LEVEL       ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL EFFECT                 cLi.l  C/Sdav)   (la/cu .)  (JkSL
                                                                                               UF         UF           UF         UF

 METHACRYLONITRILE                  000126-98-7
      NOAEL  3.2  PPM              DOG
              INHALATION:       90 DAYS       LIVER            INCREASED SGOT                             l£-3                  IRIS       005812
              INTERMITTENT                   LIVER            INCREASED SGPT                             300
                                             CENTRAL NERVOUS  LOSS OF HINDLIMB MOTOR CONTROL
                                             SYSTEM
                                             BRAIN            LESIONS
             
-------
                                 HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                             May 1995
CHEMICAL    DQSI          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT
                                                                                                     Subchronic           Chronic
                                                                                             [RfC]      [RfD]       [RfC]       [RfO]     REFERENCE
                                                                                           (mg/cu m)  (ma/ka/dav)   (ma/cu m)  (ma/kq/dav)
                                                                                              UF          UF           UF        UF
METHOXYCHLOR                        000072-43-5
     NOEL  5.01 MG/KG/DAY       RABBIT
             ORAL: GAVAGE      13 DAYS       REPRODUCTION     LOSS OF LITTERS


            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                                                       5E-3
                                                                                                       1000
                                                                                                                  IRIS
                                                                                IRIS       010357
                                                                                                                                       010909
            CHRONIC RfC COMMENT:   THE CHRONIC INHALATION RfC  IS CONSIDERED NOT VERIFIABLE  (11/07/91) BY THE RfD/RfC WORK GROUP.


METHOXYETHANOL ACETATE.  2-       000110-49-6

            CHRONIC [RfO] COMMENT-  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            SUBCHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHOXYETHANOL. 2-
     NOAEL 93 MG/CU M
              INHALATION:
              INTERMITTENT
                                      000109-86-4
                                RABBIT
                               13 WEEKS
TESTICLE
EFFECTS
2E-1
100
                                                                      IRIS
                                                                           010372
            SUBCHRONIC [RfD] COMMENT-   ALSO SEE HEAST TABLE 2:   ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
            CHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
METHYL  ACETATE
     NOEL  1156 MG/KG/DAY       RAT
              ORAL: GAVAGE      90 DAYS
                                       000079-20-9

                                             LIVER
                                             LIVER
                 INCREASED ALKALINE PHOSPHATASE
                 INCREASED SGPT
                                           1E+1
                                           100
                                1E+0
                                1000
                                                                                           010002
             CHRONIC  [RfD] COMMENT:  CALCULATED FROM DATA OBTAINED WITH METHANOL BY MULTIPLYING BY THE  MOLECULAR WEIGHT RATIO (74.08/32.04).
 IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                  1-66

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                 May 1995
 CHEMICAL     J2QS£          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
 TARGET
                                                            CRITICAL EFFECT
                                                                                         Subchronic          Chronic
                                                                                 [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                                                               (ing/cu m)  dnq/ko/dav)   (mo/cu m)  (mo/kg/day)
                                                                                  UF          UF           UF        UF
 METHYL ACRYLATE                    0000%-33-3
                                                                                                                                       010498
             CHRONIC  [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
             GENERAL  COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)


 METHYL CHLOROCARBONATE            000079-22-1
             CHRONIC  [RfD] COMMENT:  WITHDRAWN FROM IRIS (05/01/89).
             GENERAL  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
 METHYL ETHYL KETONE               000078-93-3
     NOAEL 1711 MG/KG/DAY      RAT
             ORAL: DRINKING    MULTI-        FETUS
             WATER             GENERATION
                DECREASED BIRTH WEIGHT
                                                           2E+0
                                                           1000
                                                                                                                IRIS
                     010853
             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD]
             GENERAL COMMENT: MULTI-GENERATION DEVELOPMENTAL STUDY PERFORMED WHT THE SURROGATE 2-BUTANOL. A METABOLITE OF METHYL ETHYL KETONE.
     NOAEL 1010 PPM            MOUSE
              INHALATION:       10 DAYS
              INTERMITTENT
FETUS
                                                1E+0
                                                3000
                                                DECREASED BIRTH WEIGHT


SUBCHRONIC [RfC] COMMENT:  THE CHRONIC  INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
IRIS
010845
METHYL ETHYL  KETONE PEROXIDE     001338-23-4
            CHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD]  IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
                                                                                          010948
IRK.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                     1-67

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                  May  1995
CHEMICAL    DOSE           SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
                 TARGET
               CRITICAL EFFECT
                                         Subchronic
                                 [RfC]      [RfD]
                               (mq/cu m)  (mci/ka/dav)
                                  UF          UF
                  Chronic
            [RfC]        [RfD]
           (na/cu m) (ina/kq/dav)
              UF         UF
                                                                                                                                         REFERENCE
METHYL  ISOBUTYL KETONE
     NOAEL 250 MG/(KG-DAY)
         ORAL: GAVAGE
           000108-10-1
    RAT
    13 WEEKS
WHOLE BODY
LIVER

LIVER

KIDNEY

KIDNEY

KIDNEY
LETHARGY
INCREASED RELATIVE WEIGHT IN
FEMALES
INCREASED ABSOLUTE WEIGHT IN
FEMALES
INCREASED RELATIVE WEIGHT IN
FEMALES
INCREASED ABSOLUTE WEIGHT IN
FEMALES
INCREASED URINARY PROTEIN
LEVELS IN FEMALES
8E-1
300
8E-2       010949
3000
            SUBCHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE 2:   ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfD] COMMENT:   WITHDRAWN FROM IRIS (03/01/91).  UNDER REVIEW. CURRENT NUMBER SUBJECT  TO CHANGE.
METHYL  ISOCYANATE
           000624-83-9
                                                                                                                  IRIS
                                                                                                            010013
            CHRONIC RfC COMMENT:   THE CHRONIC  INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/18/90)  BY  THE RfD/RfC WORK GROUP.
METHYLMERCURY
     CRITICAL ORAL  DOSE
      0.001 MG/KG/DAY
           022967-92-6
HUMAN
                  DEVELOPMENTAL NEUROLOGICAL ABNORMALITIES
                  IN HUMAN INFANTS
                                                              1E-4
                                                        IRIS
                                   010970
                                                                                                        10
            SUBCHRONIC [RfD] COMMENT:   THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            CHRONIC [RfD] COMMENT:  A BENCHMARK DOSE APPROACH WAS USED  RATHER THAN A NOAEL/LOAEL TO DERIVE THE RfD.
IRIS.  EPA'S INTEGRATED RISK  INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                       1-68

-------
                                 HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                            May 1995
 CHEMICAL     BQSI          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
METHYL  METHACRYLATE
     NOEL  7.5 MG/KG/OAY
             ORAL: WATER
METHYL  PARATHION

     NOAEL 2.5 PPM
             ORAL:  DIET
       000030-62-6
 RAT
24 MONTHS     KIDNEY
 RAT
90 DAYS
                     CRITICAL EFFECT
                      INCREASED RELATIVE WEIGHT


000298-00-0


      ERYTHROCYTES     CHOLINESTERASE INHIBITION
          Subchronic          Chronic
  [RfC]      [RfD]        [RfC]       [RfD]    REFERENCE
(mq/cu m)  (mq/kq/dav)   (iro/cu m) (mQ/kq/dav)
   UF         UF          UF         UF
                                                                                                     8E-2
                                                                                                     100
                                                                                                     2E-3
                                                                                                     100
                                                                                           8E-2
                                                                                           100
                                                                                           IRIS
                                           010014



                                           010015

                                           010846
METHYL STYRENE  (MIXED ISOMERS)  025013-15-4

            CHRONIC [RfD] COMMENT:   UNDER REVIEW.  ALSO SEE HEAST TABLE  2: ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY
                             (OTHER THAN CARCINOGENICITY)
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                     ' 010500
METHYL STYRENE.  ALPHA
       000098-83-9
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                    010499
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID.  4-(2
     NOEL   12 MG/KG/DAY         RAT
             ORAL:  DIET
             ORAL: DIET
                        000094-81-5
13 WEEKS

DOG
13 WEEKS

LIVER
KIDNEY

LIVER
KIDNEY
EFFECTS
EFFECTS

EFFECTS
EFFECTS
                                                                                                     1E-1
                                                                                                     100
                                                                                           IRIS
                                                                                              010008
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                1-69

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                           May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
             TARGET
                     CRITICAL EFFECT
METHYL-4-CHLOROPHENOXY)  PROPIONIC ACID. 2-(2-       000093-65-2
     NOEL  3 MG/KG/DAY         RAT
             ORAL: DIET        90 DAYS       KIDNEY           ALTERED WEIGHT
                                       Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                              (mq/cu m) (ino/ka/dav)   (ma/cu m) (ma/ka/day)
                                UF         UF          UF        UF
                                                                      1E-2
                                                                      300
                                                                                    IRIS
                                                                        010009
METHYL-4-CHLOROPHENOXYACETIC   ACID.  2-    000094-74-6
     NOEL  0.15 MG/KG/DAY       DOG
             ORAL:  DIET        52 WEEKS      KIDNEY           EFFECTS
                                           LIVER            EFFECTS

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
                                                                      5E-4
                                                                      300
                                                                                    IRIS
                                                                         010007
METHYLCYCLOHEXANE
     NOAEL 287 MG/CU M
             INHALATION:
             INTERMITTENT
RAT
1  YEAR
000108-87-2

      KIDNEY
      KIDNEY
MINERALIZATION
PAPILLARY HYPERPLASIA
3E+0
100
3E+0
100
010431
HETHYLENE  BROMIDE
       000074-95-3
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                   010501
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                               1-70

-------
                                 HEAST  TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                               May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]       [RfO]    REFERENCE
(mq/cu m)  (ma/kg/dav)   (no/cu m) (ma/kg/dav)
   UF         UF          UF         UF
HETHYLENE  CHLORIDE  (DICHLOROHETHANE)
     NOAEL 5.85 MG/KG/DAY       RAT
             ORAL:  DRINKING    24 MONTHS     LIVER
             WATER
               000075-09-2

                TOXICITY
            SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
     NOAEL 694.8 MG/CU M       RAT
             INHALATION:       2  YEARS
             INTERMITTENT
LIVER
 TOXICITY
 3E+0
 100
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
METHYLENE-BIS(2-CHLOROANILINE).  4.4'-   000101-14-4
     LOAEL 7.3 MG/KG/DAY       DOG
             ORAL             9  YEARS       LIVER           EFFECTS
                                           BLADDER          EFFECTS
                                           6E-2
                                           100
                                                          7E-4
                                                          10000
3E+0
100
                                 IRIS
                                                                7E-4
                                                                10000
            CHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE 02/10/93) BY THE RfD/RfC WORK GROUP.
METHYLENEDIPHENYL ISOCYANATE.  4.4-   (DIPHENYLMETHANE DIISOCYANATE)     000101-68-8
     NOAEL 0.2 MG/CU M          RAT
             INHALATION:       24 MONTHS     NASAL CAVITY     LESIONS                   .     2E-5
             INTERMITTENT                                                                  300
                                                                     IRIS
            SUBCHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION RfC ON IRIS WAS ADOPTED AS THE SUBCHRONIC INHALATION  [RfC].
                     005553
005552
                                           010413
                                                                                                                                    010933
                                                                          010449
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                    1-71

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)                  May 1995

                                                                                                     Subchronic          Chronic
CHEMICAL    DQSI           SPECIES                                                           [RfC]      [RfO]        [RfC]        [RfD]     REFERENCE
LEVEL       ROUTE     EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT                  (mq/cu m) (mq/kQ/dav)   (rna/cu m)  (mg/kg/dav)
                                                                                              UF         UF           UF         UF

METOLACHLOR                         051218-45-2
     NOAEL 300  PPM              RAT
             ORAL:  DIET        2  YEARS      WHOLE BODY       DECREASED WEIGHT GAIN                       1.5E-1                1.5E-1     010950
                                                                                                        100                   100

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THC SUCHRONIC ORAL [RfD].


METRIBUZIN                          021087-64-9
     NOAEL 100  PPM              DOG
             ORAL:  DIET        2  YEARS      LIVER            EFFECTS                                                          IRIS       010928
                                            KIDNEY           EFFECTS
                                            WHOLE BODY       MORTALITY
                                            WHOLE BODY       DECREASED WEIGHT

            SUBCHRONIC [RfD] COMMENT:  THE SUBCHRONIC ORAL [RfD] WAS REMOVED BECAUSE THE CHRONIC ORAL RfD  UPON WHICH IT WAS BASED IS
                               UNDER  REVIEW BY THE RfD/RfC WORK GROUP.
            CHRONIC RfD COMMENT:   THE  CHRONIC ORAL RfD. WHILE STILL ON IRIS. IS BEING RECONSIDERED BY THE  RfD/RfC WORK GROUP.


HIREX                                002385-85-5
     NOAEL 0.07 MG/KG/DAY       RAT
             ORAL:  DIET        2  YEARS      LIVER            CYTOMEGALY                                  2E-4                  IRIS       010841
                                            LIVER            FATTY METAMORPHOSIS                         300
                                            LIVER            ANGIECTASIS
                                            THYROID          CYSTIC FOLLICLES

            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.                    1-72

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENJCITY)
                                                                                                                                            May 1995
 CHEMICAL     fiQSI          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH       TARGET
                                                           CRITICAL EFFECT
                                                              Subchronic          Chronic
                                                       [RfC]      [RfO]        [RfC]        [RfD]     REFERENCE
                                                     (mg/cu m) (na/ka/dav)   (mg/cu m)  (ma/ka/dav)
                                                       UF         UF          UF         UF
 MOLINATE                            002212-67-1
     NOEL  0.2 MG/KG/DAY       RAT
              ORAL: GAVAGE                   REPRODUCTIVE     TOXICITY
                                            SYSTEM

             SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
             CHRONIC [RfD] COMMENT:  BASED ON A REPRODUCTION STUDY.
                                                                                                      2E-3
                                                                                                      100
                                                                                      IRIS       010017
MOLYBDENUM
     LOAEL 0.14 MG/KG/DAY
             ORAL: WATER.
             DIET
                               HUMAN
007439-98-7

      URINE
      JOINTS
      BLOOD
                                                            INCREASED URIC ACID
                                                            PAIN. SWELLING
                                                            DECREASED COPPER LEVELS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RFD].

                                      010599-90-3
MONOCHLORAMINE
     NOAEL 9.5 MG/KG/OAY        RAT
             ORAL:  DRINKING    2 YEARS
             WATER
                                            WHOLE BODY
                                            LIVER
                                            KIDNEY
                      WEIGHT CHANGES
                      WEIGHT CHANGES
                      WEIGHT CHANGES
5E-3
30
1E-1
100
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].


NAPHTHALENE                         000091-20-3
            CHRONIC [RfD]  COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.
IRIS
IRIS
010489
010517
NAPHTHOQUINONE.  1.4-               000130-15-4
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT

NICKEL CYANIDE                      000557-19-7
            CHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK  GROUP.
                                                                                                                                     010020
                                                                                                                                     010953
MS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                1-73

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                              May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT  LENGTH
             TARGET
NICKEL.  SOLUBLE SALTS
     NOAEL 100 PPM             RAT
             ORAL: DIET        2  YEARS
       VARIOUS
             WHOLE BODY
             ORGANS. MAJOR
CRITICAL EFFECT
 DECREASED WEIGHT
 DECREASED WEIGHT
          Subchronic
  [RfC]      [RfD]
(mq/cu m)  (mq/ka/dav)
   UF         UF
            2E-2
            300
       Chronic
  [RfC]        [RfO]
 (mg/cu m)  (mg/kq/day)
    UF         UF
                                                                                                         REFERENCE
                                                                                                                             IRIS
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC  ORAL  [RfD]
            CHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD]  WAS DERIVED FROM NICKEL MOIETY OF ADMINISTERED NICKEL CHLORIDE.
                     005579
NICOTINONITRILE                    000100-54-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                       005584
NITRIC OXIDE
       010102-43-9
            CHRONIC [RfC] COMMENT:   REFER TO APPENDIX A:  TECHNICAL INFORMATION.  SECTION  V  ON NATIONAL AMBIENT AIR QUALITY  STANDARDS.
            CHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD  HAS BEEN PERMANENTLY WITHDRAWN  (09/01/94) FROM IRIS.
                                                                                                        010451
NITRITE
     NOEL  10 PPM
             ORAL: WATER
HUMAN
       014797-65-0
             BLOOD
 METHEMOGLOBINEMIA
                                                                                                       1E-1
                                                                                                       10
                                 IRIS
            SUBCHRONIC [RfD] COMMENT:  THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN
                              POPULATION  (INFANTS).  THE CHRONIC ORAL RfD WAS ADOPTED AS  THE SUBCHRONIC ORAL [RfD].
            CHRONIC [RfD] COMMENT:   THIS  VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM  THE MOST SENSITIVE HUMAN POPULATION  (INFANTS).
                     010021
NITROANILINE.  2-                   000088-74-4

            CHRONIC [RfD] COMMENT:   THE CHRONIC ORAL [RFD]  IS CONSIDERED NOT VERIFIABLE  (06/23/92) BY THE RFD/RFC WORK GROUP.
     LOAEL 9.8 MG/CU M          RAT
             INHALATION:        4  WEEKS
             INTERMITTENT
             BLOOD
 HEMATOLOGICAL EFFECTS
 2E-3
 1000
2E-4
10000
                                                                                                        010936
010935
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                  1-74

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
 CHEMICAL     fiQSI          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
               TARGET
                                                                                                                May 1995
                                                            CRITICAL EFFECT
                                                               Subchronic
                                                       [RfC]      [RfD]
                                                     (mq/cu m) (ma/kq/dav)
                                                        UF         UF
 NITROANILINE. N-                   000099-09-2
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                  Chronic
            [RfC]       [RfD]     REFERENCE
            (im/cu m) (ma/kQ/dav)
              UF         UF
                                                                                                                                      010400
 NITROANILINE. P-
             GENERAL COMMENT:

 NITROBENZENE
     LOAEL 25 MG/CU M
              INHALATION:
              INTERMITTENT
              INHALATION:
              INTERMITTENT
        000100-01-6
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
 MOUSE
 90 DAYS
000098-95-3

      BLOOD
      ADRENAL
      KIDNEY
      LIVER
 RAT
 90 DAYS
      BLOOD
      ADRENAL
      KIDNEY
      LIVER
                               HEMATOLOGICAL EFFECTS
                               LESIONS
                               LESIONS
                               LESIONS
                               HEMATOLOGICAL EFFECTS
                               LESIONS
                               LESIONS
                               LESIONS
5E-3
1000
IRIS
                                                                                                        010024
005589
            SUBCHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            CHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS SUBCHRONIC AND CHRONICTOXICITY (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfD] COMMENT:  THE ORAL RFD. WHILE STILL AVAILABLE ON IRIS. IS BEING RECONSIDERED BY THE RFD WORKGROUP  BASED ON ROUTE
                            TO ROUTE EXTRAPOLATION.
            GENERAL COMMENT:  ALSO  SEE HEAST TABLE 3: CARCINOGENICITY.
NITROFURANTOIN
     NOAEL 300 PPM
             ORAL: DIET
        000067-20-9
 MOUSE
 13 WEEKS
                                            TESTIS
                              DAMAGE
                                                                                                       7E-1
                                                                                                       100
                                                                                              7E-2
                                                                                              1000
                                                                                                 005593
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                    1-75

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
 CHEMICAL     EQSI          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
                CRITICAL EFFECT
                                         Subchronic          Chronic
                                 [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
                               (mg/cu m)  (mq/kq/dav)   (mq/cu m)  (mq/kq/dav)
                                  UF         UF           UF         UF
 NITROGEN DIOXIDE                   010102-44-0
             CHRONIC [RfO] COMMENT:   THE CHRONIC ORAL RfO HAS BEEN PERMANENTLY WITHDRAWN (09/01/94)  FROM IRIS
             CHRONIC [RfC] COMMENT:   REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY  STANDARDS.
                                                                                                       010402
                                                                                                       010912
 NITROGEN OXIDES
             CHRONIC [RfC] COMMENT:   REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
                                                                                                       010170
NITROHETHANE                        000075-52-5
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                     010026
NITROPHENOLS
            GENERAL COMMENT:   DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                     005594
NITROPROPANE.  2-
     LOAEL 78 MG/CU M
              INHALATION:
              INTERMITTENT
        000079-46-9
 RAT
22 MONTHS    LIVER
                LESIONS
                                                             2E-2
                                                             1000
                                                                     IRIS
            SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
                                                                          010374
NITROSODIPHENYLAMINE.  P-          000156-10-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                    010027
NITROTOLUENE.  M-
     LQAEL 200 MG/KG/DAY
             ORAL:  GAVAGE
       000099-08-1
 RAT
6 MONTHS
SPLEEN
LESIONS
                                                                                                      1E-1
                                                                                                      1000
            SUBCHRONIC [RfD] COMMENT:  BASED ON  DATA OBTAINED WITH 0-NITROTOLUENE.
            CHRONIC [RfD] COMMENT:  BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
                                                                                             1E-2
                                                                                             10000
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                          010029
                                                                                                                 1-76

-------
                                  HEAST  TABLE 1:   SUBCHRONIC  AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                            May 1995
 QW2L     DQSt          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 NITROTOLUENE.  0-                   000088-72-2
      LOAEL 200 MG/KG/DAY        RAT
              ORAL: GAVAGE      6 MONTHS      SPLEEN
CRITICAL EFFECT
                             LESIONS
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]       [RfD]    REFERENCE
(im/cu m)  (ma/ka/dav)   (mq/cu m) (mg/kg/dav)
   UF        OF          OF         UF
                                                                                                     1E-1
                                                                                                     1000
                                                                                            1E-2
                                                                                            10000
                                                                          010028
 NITROTOLUENE.  P-
     LOAEL 200 MG/KG/DAY
              ORAL: GAVAGE
 RAT
6 MONTHS
       000099-99-0
                                            SPLEEN
                             LESIONS
            SUBCHRONIC [RfD]  COMMENT:  BASED ON DATA OBTAINED WITH 0-NITROTOLUENE
            CHRONIC [RfD] COMMENT:  BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
                                                                                                     1E-1
                                                                                                     1000
                                                                                            1E-2       010030
                                                                                            10000
OCTABROMOOIPHENYL ETHER           032536-52-0
     NOAEL 2.5 MG/KG/DAY        RAT
             ORAL: GAVAGE     90 DAYS      LIVER


OCTAMETHYLPYROPHOSPHORAMIDE      000152-16-9
     NOAEL 0.02 MG/KG/OAY       HUMAN
             ORAL             AT LEAST 30   BLOOD
                              DAYS
                             HISTOLOGICAL CHANGES
                             DECREASED CHOLINESTERASE
                             ACTIVITY
                                          3E-2
                                          100
                                          2E-3
                                          10
                                                                                            IRIS
                                2E-3
                                10
                                           010032
010031
OSMIUM TETROXIDE                  020816-12-0
            CHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD]  IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
                                                                                                      010954
OZONE                               010028-15-6
            CHRONIC [RfC] COMMENT:   REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON  NATIONAL AMBIENT AIR QUALITY STANDARDS.
                                                                                                      010171
PARALOEHYDE                        000123-63-7
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                                    010033
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE.  (513) 569-7254.
                                                                                                                1-77

-------
                                 HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                            May 1995
CHEMICAL    DQSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH      TARGET         CRITICAL EFFECT
                                                                                                    Subchronic           Chronic
                                                                                            [RfC]     [RfO]       [RfC]       [RfD]     REFERENCE
                                                                                          (mq/cu Hi)  (mq/kq/dav)   (ma/cu m)  (ma/ka/dav)
                                                                                             UF         UF          UF        UF
PARATHION
     NOAEL 0.064 MG/KG/DAY
             ORAL
                                      000056-38-2
                               HUMAN
                                           CHOLINESTERASE   DECREASED CHOLINESTERASE
                                                            ACTIVITY
                                          6E-3
                                          10
            SUBCHRONIC [RfO] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                     6E-3
                     10
          005598
PARTICULATE MATTER
            CHRONIC [RfC]  COMMENT:  REFER TO APPENDIX A: TECHNICAL  INFORMATION. SECTION V  ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
                                                                                                                                     010034
PEBULATE
     NOEL  5 MG/KG/DAY
             ORAL:  DIET
                                      001114-71-2
                               RAT
                              SUBCHRONIC    BLOOD
INCREASED CLOTTING TIME
5E-2
100
5E-2
100
010036
PENDIMETHALIN                       040487-42-1
     NOEL  12.5 MG/KG/DAY       DOG
             ORAL:  CAPSULE     2 YEARS       LIVER
                                                            EFFECTS
                                          4E-2
                                          300
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                     IRIS
           010037
PENTABROMOOIPHENYL ETHER          032534-81-9
     NOAEL  1.8 MG/KG/DAY        RAT
             ORAL:  GAVAGE      90 DAYS       LIVER
                                                            ALTERED ENZYME ACTIVITIES
                                          2E-2
                                          100
                     IRIS
          010038
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                               1-78

-------
                                 HEAST  TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                            May  1995
CHEMICAL     CQSi          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
             TARGET
               CRITICAL EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]        [RfC]       [RfD]    REFERENCE
                              (mq/cu m)  (ma/ko/dav)   (n»/cu m) (na/kq/day)
                                 UF        UF          UF         UF
PENTACHLOROBENZENE
     LOAEL 8.3 MG/KG/DAY
             ORAL:  DIET
       000608-93-5
RAT
100 DAYS
LIVER
KIDNEY
TOXICITY
TOXICITY
8E-3
1000
IRIS
010039
PENTACHLOROCYCLOPENTAOIENE       025329-35-5
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                      005302
PENTACHLORONITROBENZENE          000082-68-8
     NOEL   0.75 MG/KG/DAY       DOG
             ORAL:  DIET        2 YEARS       LIVER
                             TOXICITY
            SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PENTACHLOROPHENOL                 000087-86-5
     NOEL  3 MG/KG/DAY          RAT
             ORAL:  GAVAGE      62 DAYS       FETUS
                             FETOTOXICITY
                                                          3E-3
                                                          300
                                                          3E-2
                                                          100
                                                               IRIS
                                                               IRIS
                               010040
                                005600
            SUBCHRONIC  [RfD] COMMENT:  BASED ON A TERATOLOGY STUDY WITH EXPOSURE 62 DAYS PRIOR TO MATING AND THROUGHOUT GESTATION AND LACTATION.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
PENTACHLOROPROPENE.  1.1.2.3.3.-      001600-37-9
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     010041
PENTANE. N-                         000109-66-0
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005603
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                1-79

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                May  1995
CHEMICAL
LEVEL
ROUTE
                          SPECIES
                      EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (mq/ka/dav)   (mg/cu m)  (ma/kg/dav)
   UF         UF           UF        UF
PHENANTHRENE                        000085-01-8
            GENERAL COMMENT:  DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
            CHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE  (08/04/94) BY THE RfD/RfC WORK GROUP.
                                                                                                                        005604
PHENOL
     NOAEL 60 MG/KG/DAY
             ORAL: GAVAGE
                   RAT
                         000108-95-2
                               FETUS
                                                            DECREASED WEIGHT
                                                          6E-1
                                                          100
                                                                IRIS
            SUBCHRONIC [RfD]  COMMENT:  BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.  THE ORAL
                             CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            CHRONIC [RfD]  COMMENT:  BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS  6-15 OF GESTATION.

                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (02/22/90) BY THE RfD/RfC  WORK GROUP
                                           005824
                                                                                                                         010913
PHENYLENEDIAHINE. M-               000108-45-2
     NOEL  6  MG/KG/DAY          RAT
             ORAL             90 DAYS       LIVER
                                               LESIONS
                                                                                                      6E-2
                                                                                                      100
                                                                               IRIS
                                                                           010044
PHENYLENEDIAMINE. 0-               000095-54-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                                         010042
PHENYLENEDIAMINE. P-
     NOAEL  18.7 MG/KG/DAY       RAT
            ORAL:  DIET         2 YEARS
                         000106-50-3
                               WHOLE BODY
                                                            EFFECTS
                                                                               1.9E-1
                                                                               100
                                                                           010043
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                   1-80

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                        May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL EFFECT
PHENYLMERCURIC ACETATE            000062-38-4
     NOAEL 0.0084 MG/KG/DAY     RAT
             ORAL: DIET        2  YEARS       KIDNEY           DAMAGE
                                                                                                Subchronic           Chronic
                                                                                        [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                                                                                      (mq/cu m)  (mq/ka/dav)   (mo/cu m) (mq/kq/dav)
                                                                                         UF         UF          UF         UF
                                                                                                  8E-5
                                                                                                  100
                                                                                              IRIS       010277
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC  ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].  CALCULATED  BY ANALOGY TO MERCURY BY CORRECTING
                               FOR DIFFERENCES  IN MOLECULAR WEIGHT.
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO MERCURY BY CORRECTING FOR DIFFERENCES IN  MOLECULAR WEIGHT.
PHORATE
     NOAEL 0.033 MG/KG/DAY      RAT
             ORAL: DIET        13 WEEKS
                                 000298-02-2
                                       CHOLINESTERASE    INHIBITION
                                                                        2E-4
                                                                        200
                                2E-4       010403
                                200
PHOSGENE
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
                                 000075-44-5
                                                                                                                  IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (10/01/90) BY THE RfD/RfC WORK GROUP.
                                                                                                                                  010045
PHOSPHINE                           007803-51-2
     NOEL  0.026 MG/KG/DAY      RAT
             ORAL: DIET       2 YEARS
                                                                                                  3E-4
                                                                                                  100
                                                                                              IRIS
            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]


                                            KIDNEY           RENAL EFFECTS
NOAEL 1.4 MG/CU M
         INHALATION:
         INTERMITTENT
 RAT
24 WKS
3E-4
1000
3E-5
10000
                                           010174
010173
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                             1-81

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
CRITICAL EFFECT
PHOSPHORUS. WHITE                  007723-14-0

            GENERAL COMMENT:  FORMERLY LISTED AS PHOSPHORUS (INORGANIC COMPOUNDS).
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (ma/ka/dav)   (ma/cu m)  (mQ/ka/dav)
   UF         UF           UF         UF
                                                                                             IRIS
                                                                           010452
PHOTOCHEMICAL  OXIDANTS
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       010172
PHTHALIC  ACID.  M-                  000121-91-5
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      010047
PHTHALIC  ACID.  0-                  000088-99-3
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PHTHALIC  ACID.  P-                  000100-21-0
     NOEL  142 MG/KG/DAY        RAT
             ORAL: DIET       2 YEARS      BLADDER
                             HYPERPLASIA
                                           1E+0
                                           100
                                 1E+0
                                 100
                                                                                                      010046
                                                                                                                                     010048
PHTHALIC  ANHYDRIDE
     LOAEL  1562 MG/KG/DAY
             ORAL:  DIET
       000085-44-9
MOUSE
104 WEEKS     LUNG
             KIDNEY
 HISTOPATHOLOGY
 HISTOPATHOLOGY
            SUBCHRONIC  [RfO] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
     LOAEL  0.1 MG/CU M          HUMAN
             INHALATION:       12 YEARS     NOSE
             INTERMITTENT                   LUNGS
                             RHINITIS
                             BRONCHITIS
                                1.2E-1
                                300
           2E+0
           1000
                      1.2E-1
                      300
            SUBCHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
                                                                                                                           IRIS
010049
010847
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-82

-------
                                  HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN  CARCINOGENICITY)
                                                                                                                                May 1995
CHEMICAL
LEVEL
ROUTE
                           SPECIES
                      EXPERIMENT LENGTH
POLYBROMINATED BIPHENYLS
     LOAEL 0.07 MG/KG/DAY       RAT
             ORAL: GAVAGE      25 WEEKS
                                            TARGET         CRITICAL EFFECT
                               LIVER            INCREASED WEIGHT
                               LIVER            LESIONS
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mq/cu m)  (mq/kq/dav)   (ma/cu m) (ma/kq/dav)
   UF         UF          UF         UF
                                                                                                       7E-5
                                                                                                       1000
                                                                                                                            7E-6
                                                                                                                            10000
                                            010050
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
POTASSIUM CYANIDE
     NOAEL 27 MG/KG/DAY         RAT
             ORAL: DIET        2  YEARS
                         000151-50-8

                               WHOLE BODY
                               THYROID
                               NERVE
                                                            DECREASED WEIGHT
                                                            EFFECTS
                                                            MYELIN DEGENERATION
                                                                                                       5E-2
                                                                                                       500
                                 IRIS
            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
                              THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
POTASSIUM SILVER CYANIDE
     NOAEL 82.7 MG/KG/DAY       RAT
             ORAL: DIET        2 YEARS
                         000506-61-6

                               WHOLE BODY
                               THYROID
                               NERVE
                                                            DECREASED WEIGHT
                                                            EFFECTS
                                                            MYELIN DEGENERATION
                                                                                                       2E-1
                                                                                                       500
                                 IRIS
            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
                              THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
010278
010279
PROFLURALIN
     NOEL  3  MG/KG/DAY
             ORAL: DIET
                         026399-36-0
                  RAT
                  SUBCHRONIC
                                                            NONE OBSERVED
                                                                                          6E-3
                                                                                          500
                                                                                                                            6E-3
                                                                                                                            500
                                            010051
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                     1-83

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                                      May  1995
 CHEMICAL    EQSE          SPECIES
 LEVEL       ROUTE    EXPERIMENT LENGTH       TARGET
 PRONAMIDE                           023950-58-5
      NOEL  7.5 MG/KG/DAY        DOG
              ORAL:  DIET        2 YEARS
                     CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (nn/ka/dav)   (mq/cu m)  (mq/kq/dav)
   UF         UF           UF         UF
                                                            NONE OBSERVED


             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC  ORAL [RfD]
 PROPACHLOR
     NOEL  13.3 MG/KG/DAY       RAT
              ORAL: DIET        90 DAYS
001918-16-7
      WHOLE BODY
                                                            DECREASED WEIGHT GAIN
 PROPAZINE                           000139-40-2
     NOEL  5 MG/KG/DAY          RAT
             ORAL: DIET        2  YEARS       WHOLE BODY       DECREASED WEIGHT GAIN


             SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].


 PROPIONITRILE                       000107-12-0
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT


 PROPYL ALCOHOL. N-                 000071-23-8
             GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                7.5E-2
                                                                100
                                                                                                      1.3E-1
                                                                                                      100
                                                               2E-2
                                                               300
                                 IRIS       010280
                                                                                     IRIS
                                           010175
                                IRIS       010052
                                                                                              010053
                                                                                                                                    005627
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                               1-84

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
 CHEMICAL     DOSE          SPECIES
 LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
 PROPYLENE  GLYCOL
      NOEL  50000 PPM
              ORAL:  DIET
      NOEL  6 *
              ORAL: DIET
        000057-55-6
 DOG
 2 YEARS
 RAT
20 WEEKS
                                            KIDNEY
                                                            CRITICAL EFFECT
          Subchromc          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (mg/kq/dav)   (mg/cu m)  (mq/kq/dayl
   UF          UF           UF        UF
                                            ERYTHROCYTES     DECREASED COUNT
                                            BLOOD           DECREASED HEMATOCRIT
                                            BLOOD           DECREASED HEMOGLOBIN
                                                                                             2E+1
                                                                                             100
                                                            LESIONS
                                                                                                      3E+1
                                                                                                      100
                                                                                                                 IRIS
             CHRONIC RfC COMMENT:   THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/25/91) BY THE RfD/RfC WORK GROUP.
                                           005631




                                           005629


                                           010914
 PROPYLENE GLYCOL  MONOETHYL ETHER     001569-02-4
     NOEL  680 MG/KG/DAY        RAT
              ORAL: DRINKING    30 DAYS       WHOLE BODY
              WATER
                              DECREASED WEIGHT GAIN
                                                                        7E+0
                                                                        100
                                 7E-1
                                 1000
                                                                                                                 IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/25/91) BY THE RfD/RfC WORK GROUP.
                     005488
                                                                                                                                      010915
PROPYLENE GLYCOL MONOMETHYL ETHER
     NOEL  947 MG/KG/DAY        RAT
             ORAL: GAVAGE     35 DAYS
     NOAEL 1000  PPM
             INHALATION:
             INTERMITTENT
             000107-98-2

             LIVER
             KIDNEY
                                                            HISTOPATHOLOGY
                                                            HISTOPATHOLOGY
RAT. RABBIT
13 WEEKS      CENTRAL  NERVOUS  EFFECTS
             SYSTEM
           7E+0
           100
           7E-1
           1000
 2E+1
 30
IRIS
005486
                     010276
IRK.  EPA-S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                1-85

-------
                                 HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                              May 1995
CHEMICAL    BEE.          SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH      TARGET         CRITICAL EFFECT
                                                                     Subchronic          Chronic
                                                              [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                                            (mg/cu m) (ma/ka/dav)   (ma/cu m)  (mg/kg/dav)
                                                               UF         UF           UF         UF
PROPYLENE OXIDE                    000075-56-9
     LOAEL 71  MG/CU M           RAT
              INHALATION:        2 YEARS       EPITHELIUM       UNSPECIFIED
              INTERMITTENT
                                                             3E-2
                                                             100
                                                     IRIS
            SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION  [RFC].
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                                                        010375
PYRENE                               000129-00-0
     NOAEL 75 MG/KG/DAY         MOUSE
             ORAL: GAVAGE      13 WKS        KIDNEY
                             EFFECTS
                                          3E-1
                                          300
                                                                                             IRIS
            CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94)  BY THE RfD/RfC WORK GROUP
                                010176
                                                                                                        010968
PYRIDINE
     NOAEL 1 MG/KG/DAY          RAT
             ORAL: GAVAGE      90 DAYS
       000110-86-1

             LIVER
             LIVER
INCREASED WEIGHT
INCREASED RELATIVE WEIGHT
1E-2
100
                                                                IRIS
010055
RDX /  (CYCLONITE)
     NOEL  0.3 MG/KG/DAY
             ORAL
       000121-82-4
 RAT
105 WEEKS     PROSTATE
             PROSTATE
INFLAMMATION
HEMOSIDEROSIS
3E-3
100
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                IRIS
010056
RONNEL                               000299-84-3
     NOAEL 5 MG/KG/DAY          RAT
             ORAL: DIET        2  YEARS       LIVER
                             EFFECTS
                                           5E-2
                                           100
                     5E-2
                     100
                                                                                                        010057
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                  1-86

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH      TARGET
                            CRITICAL EFFECT
                                                                                        Subchronic           Chronic
                                                                                [RfC]      [RfO]       [RfC]       [RfD]     REFERENCE
                                                                              (mg/cu m)  (ma/ko/day)   (ma/cu m)  (ma/kg/dav)
                                                                                 UF         UF          UF         UF
SELENIOUS ACID                     007783-00-8
     NOAEL 0.046 MG/KG/DAY      HUMAN
             ORAL: DIET                     WHOLE BODY       SELENOSIS.  CLINICAL


            SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
                                                                       5E-3
                                                                       3
                                                                                             IRIS      010504
SELENIUM
     NOAEL 0.853 MG/DAY
             ORAL: DIET
HUMAN
       007782-49-2
             WHOLE BODY
                                                SELENOSIS. CLINICAL
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
5E-3
3
                                                                                             IRIS
                                                                                                                          010404
SELENOUREA
     NOAEL 0.072 MG/KG/DAY
             ORAL: DIET
       000630-10-4
HUMAN
                                                                        5E-3
                                                                        15
                               WHOLE BODY       SELENOSIS


CHRONIC [RfD] COMMENT:  WITHDRAWN  FROM IRIS (05/01/91).  UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
                     5E-3
                     15
                                                                                                        010473
SILVER
     LOAEL 0.014 MG/KG/DAY
              IV
       007440-22-4
 HUMAN
2-9 YEARS     SKIN
                                                ARGYRIA
5E-3
3
             SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS  ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
             CHRONIC  [RfD] COMMENT:   BASED ON A TOTAL IV DOSE OF  1 GRAM.
                                                                                                                IRIS
                                010453
 IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                   1-87

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)                  May 1995

                                                                                                     Subchronic          Chronic
CHEMICAL     QQSI          SPECIES                                                           [RfC]      [RfD]        [RfC]        [RfD]     REFERENCE
LEVEL        ROUTE     EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT                 (ma/cu m) (mq/ka/dav)   (mo/cu m)  (ma/ka/dav)
                                                                                              UF         UF          UF         UF

SILVER  CYANIDE                     000506-64-9
     NOAEL 55.7 MG/KG/OAY        RAT
             ORAL: DIET        2 YEARS      WHOLE BODY      DECREASED WEIGHT                           1E-1                  IRIS       010283
                                            THYROID         EFFECTS                                    500
                                            NERVE           MYELIN DEGENERATION

             SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY  TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
                              THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
             CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY  TO  FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.


SIHAZINE                            000122-34-9
     NOAEL 0.52 MG/(KG-DAY)      RAT
             ORAL: DIET        2 YEARS      WHOLE BODY      DECREASED WEIGHT GAIN                      5E-3                  IRIS       010955
                                            BLOOD           HEMATOLOGICAL EFFECTS                      100

             SUBCHRONIC [RfD] COMMENT:  THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY


SODIUM  CYANIDE                     000143-33-9
     NOAEL 20.4 MG/KG/DAY        RAT
             ORAL: DIET                     CENTRAL NERVOUS  EFFECTS                                    4E-2                  IRIS       005640
                                            SYSTEM                                                     500

             SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY  TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
                              THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
             CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY  TO  FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.

SODIUM  DIETHYLDITHIOCARBAMATE    000148-18-5
     NOEL  30 MG/KG/DAY          RAT
             ORAL              90 DAYS      EYE             CATARACTS                                  3E-1                  IRIS       005644
                                            WHOLE BODY      DECREASED WEIGHT                           100

            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.



IRIS.  EPA'S INTEGRATED RISK  INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION  RISK  INFORMATION HOTLINE:  (513) 569-7254.                     1-88

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGEN1CITY)
                                                                                                              May 1995
 CHEMICAL     CQSI          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 SODIUM METAVANADATE               013718-26-8
     NQAEL 10 PPM               RAT
              ORAL:  DRINKING    3 MONTHS      KIDNEY
              WATER
                                                            CRITICAL EFFECT
                              IMPAIRED FUNCTION
                                                                                        Subchronic          Chronic
                                                                                [RfC]      [RfD]        [RfC]        [RfD]     REFERENCE
                                                                               (mq/cu m) (mg/kg/dav)   (mg/cu m)  (mg/kg/day)
                                                                                 UF         UF          UF         UF
                                                                        1E-2
                                                                        100
                                                                                                                1E-3
                                                                                                                1000
                     005735
 STRONTIUM.  STABLE
     NOAEL 190 MG/KG/DAY
              ORAL: DRINKING
              WATER
       007440-24-6
 RAT, YOUNG
20 DAYS       BONE
                                                RACHITIC CHANGES


SUBCHRONIC  [RfD] COMMENT:  THE  CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
                                                                        6E-1
                                                                        300
           IRIS
010842
STRYCHNINE                          000057-24-9
     LOAEL 2.5 MG/KG/DAY        RAT
              ORAL: GAVAGE      28 DAYS       UNSPECIFIED
                                            UNSPECIFIED
            GENERAL COMMENT:   THE  LOAEL IS ALSO THE  FEL.
STYRENE
       000100-42-5
     NOAEL 22 PPM
              INHALATION:
             OCCUPATIONAL
HUMAN
                             TOXICITY
                             HISTOPATHOLOGY
             CENTRAL           EFFECTS
             NERVOUS SYSTEM
                                                                               3E+0
                                                                               10
                                                                                          3E-3
                                                                                          1000
           IRIS
                                                                                                                            IRIS
IRIS
            CHRONIC [RfC] COMMENT:  THE MEAN DURATION OF EXPOSURE FOR 50 WORKERS WAS 8.6 YEARS  AIR EXPOSURE CONCENTRATIONS WERE
                              ESTIMATED FROM THE SUMMATION OF THE PRINCIPLE  URINARY METABOLITES OF STYRENE  MANDELIC ACID AND
                              PHENYLGLYOXYLIC ACID.  SEE IRIS FOR MORE INFORMATION.
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY
010285
010059

010511
SUCCINONITRILE-                     000110-61-2
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT


IRIS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                      005585
                                                                                                                  1-89

-------
                                 HEAST TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
               CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfO]       [RfC]        [RfD]
(rnq/cu m)  (mQ/ka/dav)   (ma/cu m)  (ma/ka/dav)
   UF         UF           UF        UF
SULFUR DIOXIDE                     007446-09-5
            CHRONIC [RfC] COMMENT:  REFER TO APPENDIX A: TECHNICAL  INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
      May 1995


  REFERENCE





010505
SULFUR OXIDES
            CHRONIC [RfC]  COMMENT:  REFER TO APPENDIX A: TECHNICAL  INFORMATION.  SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
                                                                                                       010035
SULFURIC  ACID
     NOAEL  0.066-0.098 MG/CU M  HUMAN
             INHALATION
        007664-93-9

             RESPIRATORY
             SYSTEM
                RESPIRATORY EFFECTS
            CHRONIC [RfC]  COMMENT:  REPORTED EFFECTS OCCURRED AT PORTAL OF ENTRY.  ESTIMATES OF MG/DAY REFERENCE  DOSES ARE
                              INAPPROPRIATE BECAUSE EFFECTS AT PORTAL OF ENTRY DEPEND ON  CONCENTRATION IN AIR. AN ACCEPTABLE
                              AIR CONCENTRATION OF 0.07 MG/CU M WAS ESTIMATED BY CARSON ET AL (1981) FROM AVAILABLE DATA.
                                                                                                                                      005647
TEMEPHOS                             003383-96-8
     NOAEL  200 PPM              RAT
             ORAL:  DIET       99 DAYS
                                                                       2E-1
                                                                       100
                                                                                                                           2E-2       010060
                                                                                                                           1000
TERBUFOS
     NOAEL  0.0025 MG/KG/DAY
             ORAL:  DIET
       013071-79-9
 DOG
6 MONTHS
CHOLINESTERASE   INHIBITION
            2.5E-5
            100
                                                                                                                           2.5E-5    010408
                                                                                                                           100
TEREPHTHALIC ACID                  000100-21-0
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                       010474
TETRACHLOROAZOXYBENZENE           021232-47-3
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      010064
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-90

-------
                                 HEAST TABLE  1:   SUBCHRONIC  AND CHRONIC  TOXICITY (OTHER THAN CARCINOGEN1CITY)
                                                                                              May  1995
CHEMICAL    CQ$t          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
TARGET
TETRACHLORQBENZENE.  1.2.4.5-     000095-94-3
     NOAEL 0.34 MG/KG/QAY       RAT
             ORAL:  DIET       13 WEEKS      KIDNEY
CRITICAL  EFFECT
               LESIONS
         Subchronic          Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mq/cu m) (ma/kQ/dav)   (irc/cu m) (mg/kg/dav)
   UF         UF          UF        UF
                                                                                                    3E-3
                                                                                                    100
                                                                             IRIS
                                                                         010286
TETRACHLOROCYCLOPENTADIENE       000695-77-2
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                  005303
TETRACHLOROETHANE. 1.1.1.2-      000630-20-6
     LOAEL 89.3 MG/KG/DAY       RAT
            ORAL:  GAVAGE       103 WEEKS     LIVER
                                           KIDNEY
               LESIONS
               LESIONS
                                          3E-2
                                          3000
            SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TETRACHLOROETHYLENE               000127-18-4
     NOAEL  14 MG/KG/DAY        MOUSE
             ORAL             6  WEEKS       LIVER
               HEPATOTOXICITY
                                                                                                    1E-1
                                                                                                    100
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                IRIS
010407
                                                                             IRIS
                                                                         005650
TETRACHLOROHYDRAZOBENZENE        071753-42-9
            GENERAL COMMENT:  DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                  010065
TETRACHLOROPHENOL.  2.3.4.5-      004901-51-3
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                  005324
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                  1-91

-------
                                 HEAST TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                               May  1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE-    EXPERIMENT LENGTH
 TARGET
CRITICAL EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]       [RfD]    REFERENCE
(mq/cu m)  (ma/ka/dav)   (ma/cu m) (ma/ka/dav)
   UF         UF          UF         UF
TETRACHLOROPHENOL. 2.3.4.6-      000058-90-2
     NOAEL  25 MG/KG/DAY         RAT
             ORAL:  GAVAGE      90 DAYS       LIVER
                                           LIVER
                INCREASED WEIGHT
                CENTRILOBULAR HYPERTROPHY
                                          3E-1
                                          100
                                IRIS
          005323
TETRACHLOROPHENOL. 2.3.5.6-      000935-95-5
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                        005325
TETRACHLOROPROPENE.  1.1.2.3-     010436-39-2
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                        010066
TETRACHLOROVINPHOS /  (STIROPHOS)
     NOEL  3.1 MG/KG/DAY        DOG
             ORAL:  DIET        2 YEARS
         000961-11-5
LIVER
KIDNEY
WHOLE BODY
 INCREASED WEIGHT
 INCREASED WEIGHT
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
           3E-2
           100
IRIS      010067
TETRAETHYL DITHIOPYROPHOSPHATE  003689-24-5
     NOEL  0.5 MG/KG/DAY        RAT
             ORAL:  DIET        3 MONTHS      ERYTHROCYTES

                                           BLOOD
                DECREASED CHOLINESTERASE
                ACTIVITY
                DECREASED CHOLINESTERASE
                ACTIVITY
                                          5E-3
                                          100
                                IRIS       010287
THALLIC OXIDE                      001314-32-5
            CHRONIC  [RfD] COMMENT-   THE CHRONIC ORAL [RfD]' IS CONSIDERED NOT VERIFIABLE (07/22/93)  BY THE RfD/RfC WORK GROUP.
                                                                                        010956
IRIS.  ERA'S INTEGRATED RISK  INFORMATION SYSTEM. IS UPDATED MONTHLY  FURTHER INFORMATION-  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                   1-92

-------
                                  HEAST  TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                       May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
       TARGET
CRITICAL EFFECT
          Subchromc
  [RfC]      [RfD]
(mg/cu m)  (mg/kg/dav)
   UF          UF
      Chronic
 [RfC]        [RfD]
(mg/cu m)  (mg/kg/dav)
   UF         UF
                                                                                                  REFERENCE
THALLIUM (I)  ACETATE
     NOAEL 0.26 MG/KG/DAY       RAT
             ORAL              90 DAYS
000563-68-8

      LIVER
      BLOOD
      HAIR
 INCREASED  SGOT
 INCREASED  SERUM LDH
 ALOPECIA
                                                                                                       9E-4
                                                                                                       300
                                 IRIS
            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO THALLIUM CD  SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE  BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I)  CARBONATE
     NOAEL 0.23  MG/KG/DAY       RAT
             ORAL              90 DAYS
006533-73-9

      LIVER
      BLOOD
      HAIR
 INCREASED  SGOT
 INCREASED  SERUM LDH
 ALOPECIA
            8E-4
            300
                                                                                                                            IRIS
            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO THALLIUM (I)  SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE  BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM  (I) CHLORIDE
     NOAEL  0.23 MG/KG/DAY       RAT
             ORAL              90 DAYS
007791-12-0

      LIVER
      BLOOD
      HAIR
 INCREASED SGOT
 INCREASED SERUM LDH
 ALOPECIA
            BE-4
            300
          IRIS
            SUBCHRONIC [RfD]  COMMENT:  CALCULATED BY ANALOGY TO THALLIUM (I)  SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE  BY CORRECTING FOR MOLECULAR WEIGHT  DIFFERENCES.
                    005664
                     005668
005672
THALLIUM.  INSOLUBLE  SALTS
            CHRONIC [RfD] COMMENT:  REFER TO IRIS  FOR OTHER THALLIUM SALTS.
                                                                                                 010458
IRIS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                           1-93

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                      May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
      TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu m)  (mq/kq/dav)   (mg/cu m)  (mq/kq/dav)
   UF         UF           UF         UF
THALLIUM  (I) NITRATE
     NOAEL  0.26 MG/KG/DAY       RAT
             ORAL             90 DAYS
010102-45-1

      LIVER
      BLOOD
      HAIR
 INCREASED SGOT
 INCREASED SERUM LDH
 ALOPECIA
            9E-4
            300
IRIS
005676
            SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY  TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
            CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO  THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM  SELENITE
012039-52-0
                                                                                                                                      010957
            CHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS  WITHDRAWN FROM IRIS (08/01/93)  THE CHRONIC ORAL  [RfD] IS
                             CONSIDERED NOT  VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
THALLIUM  (I) SULFATE
     NOAEL  0.25 MG/KG/DAY       RAT
             ORAL             90 DAYS
007446-18-6

      LIVER
      BLOOD
      HAIR
 INCREASED  SGOT
 INCREASED  SERUM LDH
 ALOPECIA
            8E-4
            300
IRIS
005682
THIOCYANOMETHYLTHIO)BENZOTHIAZOLE,  2-(
     NOEL  25 MG/KG/DAY         RAT
             ORAL: DIET       SUBCHRONIC     STOMACH
             021564-17-0

                      LESIONS
                                           3E-1
                                           100
                                 3E-2
                                 1000
           010068
            SUBCHRONIC [RfD] COMMENT:  BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
            CHRONIC [RfD]  COMMENT:  BASED ON CONFIDENTIAL BUSINESS  INFORMATION DATA
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                          1-94

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
LEVEL
             BQSI          SPECIES
             ROUTE    EXPERIMENT LENGTH
                                            TARGET
                CRITICAL EFFECT
 THIOFANOX
     NOAEL 0.025 MG/KG/DAY      DOG
              ORAL              8 DAYS
                                      013196-18-4
                                            CHOLINESTERASE   DECREASED CHOLINESTERASE
                                                            ACTIVITY
             SUBCHRONIC  [RfD] COMMENT:  BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
             CHRONIC  [RfD] COMMENT:  BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
          Subchronic           Chronic
  [RfC]      [RfD]       [RfC]       [RfD]
(mq/cu m)  (mQ/ka/dav)   (mo/cu m) (mq/kq/dav)
   UF         UF          UF         UF
                                                                                                                                             May 1995


                                                                                                                                         REFERENCE
                                                                                                        3E-4
                                                                                                        100
                                                                                 3E-4
                                                                                 100
                                            010069
THIRAM
     NOAEL 0.61 MG/KG/DAY
              ORAL
                                      000137-26-8
                               FERRET
                              24 WEEKS
                                            REPRODUCTION
                                                            IMPAIRED
                                                                                                        6E-3
                                                                                                        100
                                                                                                                             IRIS
                                                                                            010459

                                                                                            010070
TIN AND COMPOUNDS
     NOAEL 2000 PPM             RAT
             ORAL: DIET        2 YEARS
                                            LIVER
                                            KIDNEY
                                                             LESIONS
                                                             LESIONS
                                                           6E-1
                                                           100
                                 6E-1
                                 100
            SUBCHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT
            CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
005688
TOLUENE
     NOAEL 223 MG/KG/DAY
             ORAL: GAVAGE
                                     000108-88-3
                               RAT
                              13 WEEKS
LIVER
KIDNEY
                                                            ALTERED WEIGHT
                                                            ALTERED WEIGHT
                                                                                                       2E+0
                                                                                                       100
                                 IRIS
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER.  (513)  569-7300.
                                                                                                                  IRIS
010469
                                                                                                                                       010844
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                 1-95

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                             May 1995
CHEMICAL     DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (mQ/kq/dav)   (ma/cu m)  (mg/kg/dav)
   UF         UF           UF         UF
TOLUENE-2.5-DIAMINE
     NOAEL  56 MG/KG/DAY
             ORAL:  DIET
       000095-70-5
 RAT
78 WEEKS
            SUBCHRONIC  [RfD] COMMENT:   DETERMINED FROM DATA OBTAINED WITH THE  SULFATE SALT
            CHRONIC [RfD] COMMENT:  DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
TOLUENE-2.6-DIAMINE                000823-40-5
     NOAEL  16 MG/KG/DAY         RAT
             ORAL:  DIET        2 YEARS
            SUBCHRONIC [RfD] COMMENT:  DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE.
            CHRONIC [RfD] COMMENT:  DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE
                                           6E-1
                                           100
                                                                       2E-1
                                                                       100
                                 6E-1       010073
                                 100
                                                                2E-1
                                                                100
                                           010074
TOLUENEDIAMINE.  2.3-               002687-25-4
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      010071
TOLUENEDIAMINE.  3.4-               000496-72-0
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      010072
TOLUIDINE.  M-                       000108-44-1
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                      010075
TRIALLATE
     NOAEL  1.275 MG/KG/DAY
             ORAL:  DIET
       002303-17-5
 DOG
24 MONTHS     SPLEEN
             LIVER
 EFFECTS
 EFFECTS
            1.3E-2
            100
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
IRIS
010076
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                 1-96

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                                                     May 1995
 £tftll£AL     DOSE           SPECIES
 LEVEL        ROUTE     EXPERIMENT LENGTH
                                       TARGET
 TRIBROMOBENZENE.  1.2,4-
     NOAEL 5 MG/KG/DAY
             ORAL: DIET
                                 000615-54-3
                          RAT
                         45 OR 90
                         DAYS
                                            LIVER
                                            LIVER
                            CRITICAL  EFFECT
                             ALTERED WEIGHT
                             ENZYME INDUCTION
         Subchronic          Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(ma/cu m) (ma/kg/dav)   (mg/cu m) (mg/kg/dav)
   UF         UF          UF        UF
           5E-2
           100
 TRICHLORO-1.2.2-TRIFLUOROETHANE.  1.1.2-     000076-13-1


                                           WHOLE BODY      DECREASED WEIGHT


            SUBCHRONIC [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.2.
NOEL  2000 PPM
        INHALATION:
        INTERMITTENT
 RAT
24 MONTHS
                                                            3E+1
                                                            100
           3E+0
           100
TRICHLORO-2--HYDROXYDIPHENYLETHER.  2.2.41-      003380-34-5
     NOEL  500 MG/KG/DAY        RAT
             ORAL             4 WEEKS      WHOLE BODY      DECREASED WEIGHT
TRICHLOROBENZENE. 1.2.4-         000120-82-1
     NOAEL 100 PPM              RAT
             ORAL:  DRINKING                 ADRENAL
             WATER
                                                      INCREASED WEIGHT
                                                                                               4E+0
                                                                                               100
                                                                      1E-2
                                                                      1000
            SUBCHRONIC [RfD] COMMENT:   BASED ON A MULTIGENERATION REPRODUCTION STUDY.

     NOAEL  104 PPM

             INHALATION
                          RAT. RABBIT.
                          DOG. MONKEY
                         6 AND 26      LIVER
                         WEEKS
                                                           NON-ADVERSE WEIGHT CHANGES
                                                            2E+0
                                                            100
TRICHLOROCYCLOPENTADIENE         077323-84-3
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
3E+1
100
                     2E-1
                     1000
           IRIS
                                                                                                                    IRIS
                                IRIS
010077




010460

010376
                                                                                                                                   005492
                                                                                                                              010506
                                                                                                                                   010958
                                                                                                                                  005304
MS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                        1-97

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
              TARGET
               CRITICAL  EFFECT
                                        Subchronic          Chronic
                                [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                              (mq/cu m)  (mq/kg/dav)   (rog/cu m) (mg/kg/dav)
                                 UF         UF          UF         UF
TRICHLOROETHANE.  1.1.1-           000071-55-6
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER.  (513) 569-7300.
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER.  (513) 569-7300.
TRICHLOROETHANE.  1.1.2-
     NOAEL 3.9 MG/KG/DAY
             ORAL: DRINKING
             WATER
       000079-00-5
 MOUSE
90 DAYS
BLOOD
CLINICAL CHEMISTRY ALTERATIONS
4E-2
100
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS
005702
TRICHLOROFLUOROHETHANE
     LOAEL 1000 MG/KG/DAY
             ORAL
       000075-69-4
 RAT
6 WEEKS
WHOLE BODY
INCREASED MORTALITY
7E-1
1000
                                                                                                                          IRIS
                                                                                                      005502
          005500
            SUBCHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE  2: ALTERNATE METHODS  - SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
            CHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
TRICHLOROPHENOL.  2.3.4-           015950-66-0
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005330
TRICHLOROPHENOL.  2.3.5-           000933-78-8
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005331
TRICHLOROPHENOL.  2.3.6-           000933-75-5
            GENERAL  COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     005332
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                1-98

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                         May 1995
LEVEL
             QQ5I          SPECIES
             ROUTE     EXPERIMENT LENGTH
                                           TARGET
 TRICHLOROPHENOL. 2.4.5-
     NOEL  1000 PPM            RAT
             ORAL: DIET       98 DAYS
                                     000095-95-4

                                           LIVER
                                           KIDNEY
CRITICAL EFFECT
 HEPATOTOXICITY
 EFFECTS
         Subchronic          Chronic
  [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
(mq/cu m) (mo/kQ/dav)   (mq/cu tn) (mQ/ka/dav)
   UF         UF          UF        UF
                                                                                                     1E+0
                                                                                                     100
                                IRIS
                                                                                                               IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE  (04/24/91) BY THE RfD/RfC WORK GROUP.
005329
                                                                                                                                   010919
TRICHLOROPHENOL. 2.4.6-
                                     000088-06-2
                                                                                                               IRIS
            CHRONIC RfC COMMENT:  THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE  (04/24/91) BY  THE RfD/RfC WORK GROUP
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                                                   010461
TRICHLOROPHENOL. 3.4.5-          000609-19-8
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                                   005333
TRICHLOROPHENOXY) PROPIONIC ACID.  2(2.4.5-     000093-72-1
     NOEL  0.75 MG/KG/DAY       DOG
             ORAL: DIET       2 YEARS      LIVER           HISTOPATHOLOGY
            SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                                                    8E-3
                                                                                                    100
                                                                                                                         IRIS       010284
TRICHLOROPHENOXYACETIC ACID.  2.4.5-      000093-76-5
     NOEL  10 MG/KG/DAY         RAT
             ORAL:  DIET        90 DAYS
                                          KIDNEY
                                          LIVER
 WEIGHT EFFECTS
 WEIGHT EFFECTS
                                                                                                     1E-1
                                                                                                     100
TRICHLOROPROPANE.  1.1.1-         007789-89-1
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                IRIS       010178

                                           010179



                                          005705
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                             1-99

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
CHEMICAL
LEVEL
DOSE
ROUTE
                     EXPERIMENT LENGTH
TARGET
CRITICAL  EFFECT
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]
(mg/cu m)  (ma/ka/dav)   (mo/cu m)  (ma/ka/dav)
   UF         UF          UF         UF
                                                                                                                               May 1995


                                                                                                                          REFERENCE
TRICHLOROPROPANE. 1.1.2-          000598-77-6
     NOEL  100 MG/L             RAT
             ORAL:  DRINKING    13 WEEKS      LIVER            HISTOPATHOLOGY
             WATER                          KIDNEY           HISTOPATHOLOGY
                                            THYROID          HISTOPATHOLOGY
                                                                                         5E-2
                                                                                         300
                                                                                                                          IRIS
                                                                                                                        005708
TRICHLOROPROPANE. 1.2.2-          003175-23-3
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                                                        005706
TRICHLOROPROPANE. 1.2.3-          000096-18-4
     NOAEL 8 MG/KG/DAY          RAT
             ORAL              120 DAYS
                               WHOLE BODY
                               LIVER
                               KIDNEY
                               ERYTHROCYTES
                               BLOOD
                               BLOOD
                                                            TOXICITY
                                                            LESIONS
                                                            LESIONS
                                                            DECREASED COUNT
                                                            DECREASED HEMATOCRIT
                                                            DECREASED HEMOGLOBIN
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
TRICHLOROPROPENE.  1.2.3-          000096-19-5
     NOEL  18 MG/CU M           DOG
              INHALATION:        66 WEEKS      EYE
              INTERMITTENT
                                                IRRITATION
                                                         6E-2
                                                         100
                                                                                                              IRIS       005714
                                                                                                      5E-3
                                                                                                      100
                                                                              5E-3       010078
                                                                              100
            SUBCHRONIC [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
            CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                  1-100

-------
                                  HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN  CARCINOGENICITY)
                                                                                                             May 1995
 CHEMICAL     DOSE          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH
              TARGET
 TRICHLOROTOLUENE.  2.3.6-          002077-46-5
     LOAEL 0.5 PPM             RAT
              ORAL: DIET        28 DAYS       LIVER
                                            KIDNEY
                                            THYROID
                CRITICAL EFFECT
                              LESIONS
                              LESIONS
                              LESIONS
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu m)  (mq/ka/dav)   (mq/cu m)  (mq/ka/dav)
   UF         UF           UF         UF
                                                          5E-5
                                                          1000
                                           005335
TRICHLOROTOLUENE. ALPHA.2.6-
     LOAEL 0.5 PPM             RAT
             ORAL: DIET       28 DAYS
        002014-83-7

             LIVER
             KIDNEY
             THYROID
                                                            LESIONS
                                                            LESIONS
                                                            LESIONS
                                                          5E-5
                                                          1000
                                           005339
TRIFLURALIN
     NOEL  0.75 MG/KG/DAY
             ORAL: DIET
       001582-09-8
 DOG
12 MONTHS     LIVER
             BLOOD
                                                            INCREASED WEIGHT
                                                            METHEMOGLOBINEMIA
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                          7.5E-3
                                                          100
                                IRIS       010080
TRIMETHYLBENZENES
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                                                                    005727
TRINITROBENZENE.  1.3.5-
     NOAEL  0.51 MG/KG/DAY
             ORAL: WATER
       000099-35-4
 RAT
16 WEEKS
SPLEEN
                                                            INCREASED WEIGHT
            SUBCHRONIC  [RfD] COMMENT:   CALCULATED FROM DATA OBTAINED WITH 1.3-DINITROBENZENE
            CHRONIC [RfD] COMMENT:  CALCULATED FROM DATA OBTAINED WITH 1.3-DINITROBENZENE
                                                                       5E-4
                                                                       1000
                                                                                                                           IRIS       010081
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                1-101

-------
                                 HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                            May 1995
CHEMICAL     CQSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
             TARGET
CRITICAL  EFFECT
         Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mq/cu m) (mQ/ko/dav)   (mo/cu m) (ma/kg/dayl
   UF         UF          UF         UF
TRINITROPHENOLS
            GENERAL COMMENT:  DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                     010082
TRINITROPHENYLMETHYLNITRAMINE    000479-45-8
     LOAEL 125 MG/KG/DAY        RABBIT
             ORAL:  GAVAGE      9 MONTHS      LIVER
                                            KIDNEY
                                            SPLEEN
                             HISTOPATHOLOGICAL EFFECTS
                             HISTOPATHOLOGICAL EFFECTS
                             HISTOPATHOLOGICAL EFFECTS
                                           1E-1
                                           1000
                                 1E-2       010377
                                 10000
TRINITROTOLUENE. 2.4.6-
     LOAEL 0.5 MG/KG/DAY
             ORAL: GAVAGE
DOG
       000118-96-7
             LIVER
 EFFECTS
            5E-4
            1000
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.


URANIUM.  SOLUBLE SALTS
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL  SUPPORT CENTER.  (513)  569-7300.
                                                                                            IRIS
                                                                          010416
 VANADIUM
     NOAEL 5 PPM
             ORAL: DRINKING
             WATER
       007440-62-2
 RAT
LIFETIME
                                           7E-3
                                           100
                                 7E-3       005739
                                 100
 VANADIUM PENTOXIDE
     NOAEL 17.85 PPM
              ORAL: DIET
       001314-62-1
 RAT
LIFETIME
                                           9E-3
                                           100
                                 IRIS
             SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]


 IRIS. EPA'S INTEGRATED RISK  INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                           005743
                                                                                                                1-102

-------
                                 HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                      May 1995
CHEMICAL    DOSE          SPECIES
LEVEL       ROUTE    EXPERIMENT LENGTH
      TARGET
VANADIUM  SULFATE                   036907-42-3
     NOAEL  2.24 MG/KG/DAY       RAT
             ORAL: DRINKING    LIFETIME
             WATER
VERNAH /  (VERNOLATE)
     NOEL   1 MG/KG/DAY          RAT
             ORAL:  DIET
VINYL ACETATE
     NOAEL 100 MG/KG/DAY        RAT
             ORAL:   WATER     2 YEARS
001929-77-7

      WHOLE BODY


000108-05-4

      WHOLE BODY
      KIDNEY
     NOAEL  176 MG/CU M          MOUSE
             INHALATION:       104 WEEKS
             INTERMITTENT
CRITICAL  EFFECT
 DECREASED WEIGHT
 ALTERED WEIGHT
 ALTERED WEIGHT
      NASAL CAVITY     LESIONS
          Subchronic          Chronic
  [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
(mg/cu m)  (ina/kq/dav)   (im/cu m)  (ma/ka/dav)
                                                                                               005747
UF



2E-1
30
UF
2E-2
100
1E-2
100
1E+0
100

UF UF
2E-2
100
IRIS
1E+0
100
IRIS
            SUBCHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].


VINYL CHLORIDE                      000075-01-4
            SUBCHRONIC [RfC] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER  (513) 569-7300.
            SUBCHRONIC [RfD] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                           010083
                                           010417
                                                                           010418
VINYL-1-CYCLOHEXENE.  4-           000100-40-3
            GENERAL COMMENT:  DATA INADEQUATE  FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                               010084
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                         1-103

-------
                                  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
                                                                                                                                              May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH       TARGET
WARFARIN
     LOAEL  2 MG/DAY
             ORAL
                                      000081-81-2
                               HUMAN
                                                            CRITICAL EFFECT
                                                             INCREASED PROTHROMBIN TIME
                                                                                         Subchronic          Chronic
                                                                                 [RfC]      [RfD]       [RfC]        [RfD]     REFERENCE
                                                                               (mq/cu m) (ma/ka/dav)   (mg/cu m)  (mQ/ka/dav)
                                                                                  UF         UF          UF         UF
                                BLOOD


SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC  ORAL  [RfD].
3E-4
100
IRIS       010409
XYLENE.  M-
     NOAEL 250 MG/KG
             ORAL: GAVAGE
                                      000108-38-3
                               RAT
                               103 WEEKS     CENTRAL NERVOUS   HYPERACTIVITY
                                            SYSTEM
                                            WHOLE BODY       DECREASED WEIGHT
                                            WHOLE BODY
                                                                                                                2E+0
                                                                                                                100
            SUBCHRONIC [RfD] COMMENT:   CONTACT THE SUPERFUND HEALTH  RISK TECHNICAL SUPPORT CENTER.  (513) 569-7300.

            CHRONIC [RfC] COMMENT:   THE CHRONIC INHALATION [RfC]  IS  CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
                                005755
                                                                                                                                       010920
                                                                                                                             IRIS
XYLENE. MIXTURE                    001330-20-7

            SUBCHRONIC [RfD] COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300

            CHRONIC [RfC] COMMENT:   THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
                                                                                                                           010872

                                                                                                                           010921
XYLENE.  0-
     NOEL  250 MG/KG
             ORAL: GAVAGE
                                      000095-47-6
                               RAT
                               103 WEEKS     CENTRAL NERVOUS  HYPERACTIVITY
                                            SYSTEM
                                            WHOLE BODY       DECREASED WEIGHT
                                                                                                                 2E+0
                                                                                                                 100
            SUBCHRONIC [RfD] COMMENT:   CONTACT THE SUPERFUND HEALTH  RISK TECHNICAL SUPPORT CENTER.  (513) 569-7300.

            CHRONIC [RfC] COMMENT:   THE CHRONIC INHALATION [RfC]  IS  CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
                                005751
                                                                                                                                       010922
IRIS,  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                 1-104

-------
                                  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

                                                                                                     Subchronic
                                                                                                               May 1995
 CHEMICAL     CQSI          SPECIES
 LEVEL        ROUTE    EXPERIMENT LENGTH       TARGET         CRITICAL EFFECT
                                                                                          Chronic
                                                               [RfC]      [RfD]       [RfC]        [RfO]     REFERENCE
                                                             (mq/cu m)  (mq/kq/dav)   (mq/cu m)  (mq/kq/dav)
                                                               UF         UF           UF         UF
 XYLENE.  P-                           000106-42-3
             SUBCHRONIC  [RfD] COMMENT:   CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300.

             CHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE RfD/RfC WORK GROUP.
                                                                                                        010923
 ZINC  (METALLIC)
     LOAEL 1.0 MG/KG/DAY
              ORAL: DIET
              SUPPLEMENT
        007440-66-6
 HUMAN
10 WEEKS
                                BLOOD           DECREASED BLOOD ENZYME


CHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                        3E-1
                                                                        3
IRIS
010937
ZINC CYANIDE
     NOAEL 24.3 MG/KG/DAY        RAT
             ORAL: DIET        2 YEARS
       000557-21-1

             WHOLE BODY
             THYROID
             NERVE
                                                DECREASED WEIGHT
                                                EFFECTS
                                                MYELIN DEGENERATION
                                                                                                       5E-2
                                                                                                       500
IRIS
            SUBCHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING  FOR DIFFERENCES IN MOLECULAR WEIGHT
            CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
010289
ZINC PHOSPHIDE
     LOAEL 3.48 MG/KG/DAY
             ORAL: DIET
       001314-84-7
 RAT
13 WEEKS
                                WHOLE BODY
                                WHOLE BODY
                                                             DECREASED WEIGHT
                                                             DECREASED FOOD INTAKE
                                                                        3E-3
                                                                        1000
IRIS
010290
ZINEB                                012122-67-7
     LOAEL 25 MG/KG/DAY         RAT
             ORAL: DIET        2  YEARS       THYROID
                              HYPERPLASIA
                                                                                                       5E-2
                                                                                                       500
            SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
                                                                                              IRIS
                                                                                                                           010085
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254
                                                                                                                  1-105

-------
                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995


ACENAPHTHENE                                                000083-32-9
        010165  US EPA. 1989. MOUSE ORAL  SUBCHRONIC STUDY WITH ACENAPHTHENE. STUDY CONDUCTED BY HAZELTON LABORATORIES. INC..  FOR THE OFFICE OF SOLID
                WASTE. WASHINGTON.  DC.

                US EPA. 1989. RfD/RfC WORK GROUP.

ACENAPHTHYLENE                                               000208-96-8
        005202  US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACENAPHTHYLENE. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

ACEPHATE                                                     030560-19-1
        005833  CHEVRON CHEMICAL COMPANY. 1987. CONFIDENTIAL BUSINESS INFORMATION UNPUBLISHED DATA. MRID NO. 40504819

                US EPA. 1984. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR ACEPHATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA. 1989. RfD/RfC WORK GROUP.

ACETONE                                                      000067-64-1
        005204  US EPA. 1986. NINETY-DAY  GAVAGE STUDY IN ALBINO RATS USING ACETONE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR ACETONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                US EPA. 1986. RfD/RfC WORK GROUP.

ACETONE CYANOHYDRIN /  (METHYLLACTONITRILE)            000075-86-5
        005776  HAZELTON LABORATORIES AMERICA. 1988. SUBCHRONIC TOXICITY STUDY IN RATS WITH 2-METHYLLACTONITRILE. HLA STUDY NO. 2399-114. REPORT PREPARED
                FOR DYNAMAC CORPORATION.

                US EPA. 1994. RfD/RfC WORK GROUP.

ACETONITRILE                                                000075-05-8
        005210  NATIONAL TOXICOLOGY PROGRAM (NTP). 1983. 90-DAY SUBCHRONIC TOXICITY STUDIES OF ACETONITRILE IN RATS AND MICE.  REPORT TO NATIONAL
                TOXICOLOGY PROGRAM.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACETONITRILE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                US EPA. 1987. RfD/RfC WORK GROUP.


                                                                                                                                                 Rl-1

-------
                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN  CARCINOGENICITY)                                              May 1995


ACETOPHENONE                                                000098-86-2
        005212  HAGAN. EC. WH HANSEN. OG FITZHUGH.  ET AL  1967. FOOD FLAVORINGS AND COMPOUNDS OF RELATED STRUCTURE.  II. SUBACUTE AND CHRONIC TOXICITY.
                FOOD COSMET. TOXICOL. 5(2):  141-157

                US EPA. 1987. RfD/RfC WORK GROUP

        010874  US EPA. 1992. RfD/RfC WORK GROUP.

ACROLEIN                                                    000107-02-8
        010390  NEWELL GW. 1958. ACUTE AND SUBACUTE TOXICITY OF ACROLEIN.  STANFORD RESEARCH INSTITUTE.  SRI PROJECT NO. 5-868-2.

                NAS (NATIONAL ACADEMY OF SCIENCES).  1977. DRINKING WATER AND HUMAN HEALTH. WASHINGTON.  DC.

                US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACROLEIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

        010856  FERON VJ. A KRUYSSE. HP TIL.  AND HR IMMEL  1978  REPEATED  EXPOSURE TO ACROLEIN VAPOR: SUBACUTE STUDIES IN HAMSTERS. RATS AND RABBITS.
                TOXICOLOGY. 9: 47-57.

                US EPA. 1991. RfD/RfC WORK GROUP.

ACRYLAMIDE                                                  000079-06-1
        005835  BUREK JD. RR ALBEE. JE BEYER.  ET AL. 1980. SUBCHRONIC TOXICITY OF ACRYLAMIDE ADMINISTERED TO  RATS  IN THE DRINKING WATER FOLLOWED BY UP TO
                144 DAYS OF RECOVERY. J ENVIRON  PATHOL TOXICOL. 4: 157-182.

                US EPA  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACRYLAMIDE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                US EPA. 1988. RFD/RFC WORK GROUP.

        010876  US EPA. 1990. RfD/RfC WORK GROUP
                                                                                                                                                 R^2

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                                          REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC  AND  CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995


ACRYLIC  ACID                                               000079-10-7
        005836  BASF.   1993.  REPRODUCTION TOXICITY  STUDY WITH ACRYLIC ACID IN RATS:  CONTINUOUS  ADMINISTRATION  IN THE DRINKING WATER OVER 2 GENERATIONS
                 (1  LITTER  IN THE FIRST AND 1 LITTER  IN THE SECOND GENERATION).  PROJECT NO   71R0114/92011.  BASF AKTIENGELLSCHAFT.  DEPT.  OF TOXICOLOGY.
                 RHEIN.  FRG.

                 US  EPA.  1994. RfD/RfC WORK GROUP.

        010346  MILLER.  RR. JA AYERS. GC JERSEY AND  MJ MCKENNA.  1981. INHALATION TOXICITY OF ACRYLIC ACID.  FUND  APPL TOXICOL. 1(3):  271-277.

                 MILLER.  RR. JA AYERS. GC JERSEY  1979. ACRYLIC ACID 90-DAY VAPOR INHALATION STUDY WITH  RATS AND  MICE. FINAL REPORT I79RC-1024.  TOXICOLOGY
                 RESEARCH LABORATORY. HEALTH AND ENVIRONMENTAL SCIENCE. DOW CHEMICAL COMPANY. MIDLAND, MI.

                 US  EPA.  1990. RfD/RfC WORK GROUP.

ACRYLONITRILE                                              000107-13-1
        010939  TANDON  R.  DK SAXENA. SV CHANDRA.  PK  SETH. SP SRIVASTAVA. 1988. TESTICULAR EFFECTS OF ACRYLONITRILE IN MICE. TOXICOLOGY LETTERS.  42:
                 55-63.

                 BIODYNAMICS. 1980. A TWENTY-FOUR MONTH ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED TO SPARTAN RATS IN THE DRINKING
                 WATER.  VOL 1-2. PREPARED BY BIODYNAMICS.  INC  . DIVISION OF BIOLOGY AND SAFETY EVALUATION.  EAST MILLSTONE. NJ. FOR MONSANTO COMPANY.  ST.
                 LOUIS.  MO.

                 US  EPA.  1993. RfD/RfC WORK GROUP.
ADIPONITRILE                                               000111-69-3
        005157  US  EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ADIPONITRILE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

ALACHLOR                                                    015972-60-8
        005837  MONSANTO CO. 1984. MRID NO 00148923.  AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON.  DC. 20460.

                 US  EPA.  1992. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ALACHLOR. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE OF THE
                 OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH. FOR THE OFFICE OF  SOLID  WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US  EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALACHLOR. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US  EPA.  1991. RfD/RfC WORK GROUP
                                                                                                                                                   Rl-3

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                                           REFERENCES  FOR  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                              Nay 1995


ALDICARB                                                     000116-06-3
         010960   RHONE-POULENC AG COMPANY. 1992. MRID NO 423730-01.  HED DOC NO 010459. AVAILABLE FROM EPA.  WRITE TO FOI.  EPA. WASHINGTON. DC 20460.

                 UNION  CARBIDE CORP.  1971. R RAINES. JB DERNEHL. JB  BLOCK. SUPERVISING PHYSICIANS. INGESTION OF ALDICARB  BY HUMAN VOLUNTEERS' A CONTROLLED
                 STUDY  OF THE EFFECTS OF ALDICARB ON MAN.  ALO-03-77-2215. FEB 11. 1971. MRID NO 00101911.  HED DOC NO 010450. AVAILABLE FROM EPA. WRITE TO
                 FOI. EPA. WASHINGTON. DC 20460.

                 GOLDMAN LR. M SELLER. RJ JACKSON. 1990.  ALDICARB  FOOD POISONING IN CALIFORNIA.  1985-1988:  TOXICITY ESTIMATES FOR HUMANS. ARCH ENVIRON
                 HEALTH. 45(3):  141-147. HED DOC NO 010451.  010455.  010458. AVAILABLE FROM EPA.  WRITE TO FOI.  EPA.  WASHINGTON. DC 20460.

                 GOLDMAN. LR. DF SMITH. RR NEUTRA ET AL.  1990.  PESTICIDE FOOD POISONING FROM CONTAMINATED WATERMELONS IN  CALIFORNIA. 1985  ARCH ENVIRON
                 HEALTH. 45(4):  229-236.

                 HIRSCH GH. BT MORI. GB MORGAN. PR BENNET.  BC  WILLIAMS. 1987. REPORT OF ILLNESSES CAUSED BY ALDICARB-CONTAMINATED CUCUMBERS. FOOD
                 ADDITIVES AND CONTAMINANTS. 5(2): 155-60.  HED DOC NO 010455. 010458. AVAILABLE  FROM EPA.  WRITE TO FOI. EPA. WASHINGTON. DC 020460.

                 US  EPA. 1992. RfO/RfC WORK GROUP.

ALDRIN                                                        000309-00-2
         005159   FITZHUGH OG. AA NELSON AND ML QUAIFE.  1964. CHRONIC ORAL TOXICITY OF ALDRIN AND DIELDRIN IN RATS AND DOGS  FOOD COSMET TOXICOL  2'
                 551-562.

                 US  EPA. 1987. HEALTH EFFECTS ASSESSMENT  FOR ALDRIN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA
                 AND ASSESSMENT  OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US  EPA. 1985. RfD/RfC WORK GROUP.

ALLIDOCHLOR                                                  000093-71-0
         005838   US  EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLIDOCHLOR.  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

ALLYL ALCOHOL                                               000107-18-6
         005839   CARPANINI FMB.  IF GAUNT, J HARDY. ET AL   1978.  SHORT-TERM TOXICITY OF ALLYL ALCOHOL IN  RATS.  TOXICOLOGY.  9: 29-45.

                 US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL ALCOHOL.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

                 US  EPA. 1986. RfD/RfC WORK GROUP.
                                                                                                                                                   Rl-4

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995


ALLYL CHLORIDE                                             000107-05-1
        010369   BOQUIN. L. D SHUWEI.  Y AIRU. ET AL  1982.  STUDIES ON THE TOXICITY OF ALLYL CHLORIDE.  ECOTOXICOL ENVIRON SAP. 6: 19-27.

                 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL CHLORIDE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.  WASHINGTON. DC.

ALUMINUM                                                    007429-90-5
        005162   US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ALUMINUM. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

ALUMINUM PHOSPHIDE                                         020859-73-8
        010255   HACKENBURG U. 1972.  CHRONIC INGESTION BY RATS OF  STANDARD DIET TREATED WITH ALUMINUM PHOSPHIDE. TOXICOL APPL PHARMACOL.  23(1): 147-158.

                 US EPA. 1985. RfD/RfC WORK GROUP.

AMETRYN                                                      000834-12-8
        005841   CIBA-GEIGY CORPORATION.  1961. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO. 00034843. AVAILABLE FROM EPA.  WRITE TO FOI.
                 EPA. WASHINGTON. DC 20460.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMETRYN. PREPARED BY THE OFFICE  of HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US EPA. 1987. RfD/RfC WORK GROUP

AMINO-2-NAPHTHOL.  1-                                      002834-92-6
        005842   US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR l-AMINO-2-NAPHTOL AND l-AMINO-2-NAPHTOL HYDROCHLORIDE.  PREPARED  BY THE OFFICE
                 OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
                 EMERGENCY RESPONSE.  WASHINGTON, DC.

AMINO-2-NAPHTOL HYDROCHLORIDE.  1-                       001198-27-2
        005843   US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR l-AMINO-2-NAPHTOL AND l-AMINO-2-NAPHTOL HYDROCHLORIDE.  PREPARED  BY THE OFFICE  •
                 OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE.
                 WASHINGTON. DC.

AMINOPHENOL.  M-                                            000591-27-5
        005844   RE TA.  RF LOEHR. SC RODRIGUEZ. ET AL  1984  RESULTS OF TERATOGENICITY TESTING OF M-AMINOPHENOL IN SPRAGUE-DAWLEY RATS. FUND APPL TOXICOL.
                 4(1)  98-104.

                 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.  WASHINGTON. DC.


                                                                                                                                                  Rl-5

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                                           REFERENCES  FOR  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY

                                                               (OTHER  THAN CARCINOGENICITY)                                              May 1995



AMINOPHENOL.  0-                                             000095-55-6
         005845   US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.


AMINOPHENOL.  P-                                 .            000123-30-8
         005846   US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.


AMINOPYRIDINE. 4-                                           000504-24-5
         005847   KOHN  FE.  1968. FOUR-WEEK SUBACUTE ORAL TOXICITY OF  COMPOUND 1861 HYDROCHLORIDE --ALBINO RATS.  (UNPUBLISHED STUDY)  PREPARED BY INDUSTRIAL
                 BIOTEST  LABORATORIES. INC. UNDER 224-12   SUBMITTED  BY PHILLIPS PETROLEUM CO.. BARTLESVILLE. OK.  CDL: 229844-E.


                 US EPA.  1980.  4-AMINOPYRIDINE. AVITROL PESTICIDE REGISTRATION STANDARD.  PREPARED BY THE OFFICE OF  PESTICIDE PROGRAMS  US EPA  WASHINGTON
                 DC. NTIS  PB84-209907.


                 US EPA.  1989.  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR 4-AMINOPYRIDINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.


AMMONIA                                                      007664-41-7
         005166   CAMPBELL  CL. RK DAWES.  S DEOLALKAR AND MC MERRITT.  1958.  EFFECT OF CERTAIN  CHEMICALS IN WATER  ON THE FLAVOR OF BREWED COFFEE  FOOD RES
                 23: 575-579. CITED IN US EPA.  1981.                                                                                        '   """""•


                 WHO (WORLD HEALTH ORGANIZATION).  1986. ENVIRONMENTAL HEALTH CRITERIA.  54. AMMONIA.  WHO.  GENEVA.  SWITZERLAND.


                 US  EPA. 1981. AMBIENT WATER QUALITY CRITERION FOR THE PROTECTION OF HUMAN HEALTH:  AMMONIA. PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF WATER REGULATIONS  AND STANDARDS.
                 WASHINGTON. DC.


                 US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR AMMONIA. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON.  DC.


         010392   HOLNESS DL. JT PURDHAM  AND JR  NETHERCOTT. 1989.  ACUTE AND CHRONIC RESPIRATORY EFFECTS OF OCCUPATIONAL EXPOSURE TO AMMONIA   AMIND HYG
                 ASSOC J.  50: 646-650.


                 BRODERSON JR.  JR LINDSEY AND JE CRAWFORD. 1976.  THE ROLE  OF ENVIRONMENTAL AMMONIA  IN RESPIRATORY MYCOPLASMOSIS OF  RATS. AM  J PATHOL.  85:
                 J.lb~ UU .


                 US EPA. 1991.  RfD/RfC WORK GROUP.
                                                                                                                                                  Rl-6

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995



ANILINE                                                      000062-53-3
        010370  OBERST FW. E HACKLEY. C COMSTOCK   1956. CHRONIC TOXICITY OF ANILINE VAPOR (5PPM)  BY  INHALATION. ARCH INO HEALTH 13:379-384.

                US  EPA.  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANILINE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

                US  EPA.  1990. RfD/RfC WORK GROUP.

ANTHRACENE                                                  000120-12-7
        010166  US  EPA.  1989. SUBCHRONIC TOXICITY  IN MICE WITH ANTHRACENE. FINAL REPORT.  HAZELTON LABORATORIES AMERICA. INC. PREPARED FOR THE OFFICE  OF
                SOLID WASTE. WASHINGTON. DC.

                US  EPA.  1991. DRINKING WATER CRITERIA DOCUMENT FOR ANTHRACENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

                US  EPA.  1989. RfD/RfC WORK GROUP.

        010964  US  EPA.  1994. RfD/RfC WORK GROUP.

ANTIMONY PENTOXIDE                                        001314-60-9
        005174  SCHROEOER HA. M KITCHENER AND AP  NASON.  1970. ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD  IN RATS: LIFE-TIME STUDIES. J.  NUTR. 100: 59-66.

                US  EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.

ANTIMONY POTASSIUM TARTRATE                              000304-61-0
        005234  SCHROEDER HA. M MITCHENER AND AP  NASON.  1970. ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD  IN RATS: LIFE-TIME STUDIES. J.  NUTR. 100: 59-69.

                US  EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.
                                                                                                                                                   Rl-7

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                                           REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN  CARCINOGENICITY)                                              May 1995


ANTIMONY TETROXIDE                                        001332-81-6
         005238   SCHROEDER HA. M MITCHENER AND AP NASON. 1970. ZIRCONIUM.  NIOBIUM. ANTIMONY AND LEAD IN RATS:  LIFE-TIME STUDIES. J. NUTR.  100:  59-69.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMFNT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY M
                 US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND

                            ENVIRONMENTAL CRITERIA AMD «SESSHEMT OFFICE. CINCINNATI. OH FOR THE CFFlS OF SollD I^ASTE
                           . IX,.
ANTIMONY TRIOXIDE                                          001309-64-4
         005242   SCHROEDER HA. M MITCHENER AND AP NASON. 1970.  ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES.  J.  NUTR.  100: 59-69.

                 US EPA. 1987. HEALTH EFFECTS  ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY                                        '
                US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTS
                          :  rRONMENTAL CRITERIA m ASSESSMENT OFFICE- CINCINNATI-  w FOR ™E
ANTIMONY.  METALLIC                                         007440-36-0

        005170  SCHROEDER HA.  M MITCHENER AND AP NASON.  1970  ZIRCONIUM. NIOBIUM.  ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR. 100: 59-66.

                US EPA. 1987.  HEALTH EFFECTS ASSESSMENT  FOR ANTIMONY AND COMPOUNDS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY LND REM^IAlTsPmSE^fNGTS ™'
                US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTS

                          ;  ™m£mi CRITERIA m ASSESSMENT OFFICE'  CINCINNAT<- * FOR THE OFFICE

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995



ARAMITE                                                      000140-57-8
        005849  OSER BL. M OSER  1962.  2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE)  II.  CARCINOGENICITY. TOXICOL APPL PHARMACOL. 4:
                70-88.

                US EPA. 1989. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR ARAMITE. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON.  DC.

        005850  POPPER H. SS STERNBERG. BL OSER AND M OSER.  1960.  THE  CARCINOGENIC EFFECT OF ARAMITE IN  RATS. CANCER. 13(5): 1035-1046.

                OSER BL AND M OSER.  1962. 2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE).  CARCINOGENICITY. TOXICOL APPL PHARMACOL. 4:
                70-88.

                US EPA. 1989. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR ARAMITE. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON.  DC.

AROCLOR  1248                                            012672-29-6
        010940  US EPA. 1993. RfD/RfC WORK GROUP.

AROCLOR  1254                                            011097-69-1
        010963  US EPA.  1994   RfD/RfC WORK GROUP.

ARSENIC,  INORGANIC                                         007440-38-2
        010434  TSENG WP. 1977. EFFECTS AND DOSE-RESPONSE RELATIONSHIPS OF SKIN CANCER AND BLACKFOOT DISEASE WITH ARSENIC. ENVIRON. HEALTH PERSPECT. 19:
                109-119.

                TSENG. WP. HM CHU.  SW HOU. JM FONG. CS LIN.  S YEH.  1968. PREVALENCE OF SKIN CANCER IN AN ENDEMIC AREA OF CHRONIC ARSENICISM IN  TAIWAN. J.
                NATL. CANCER INST.  40:  453-463.

                US EPA. 1990. RfD/RfC WORK GROUP.

ATRAZINE                                                     001912-24-9
        010855  CIBA-GEIGY CORP. 1986.  MRID NO 00141874. 00157875.  00158930. 40629302. HED DOC NO 005940.  006937. AVAILABLE FROM EPA. WRITE TO  FOI.  EPA.
                WASHINGTON. DC 20460.

                CIBA-GEIGY CORP. AGRICULTURAL DIVISION. 1987. MRID NO  40431301. 41293801.HED DOC NO 006718.  006937. 007647. AVAILABLE FROM EPA.  WRITE TO
                FOI. EPA. WASHINGTON. DC  20460.

                US EPA. 1992. RfD/RfC WORK GROUP.
                                                                                                                                                  Rl-9

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                              (OTHER  THAN  CARCINOGENICITY)                                              May 1995


BARIUM                                                       007440-39-3
        010348  WONES. RG. BL STADLER.  LA FROHMAN   1990  LACK OF EFFECT  OF DRINKING WATER BARIUM ON CARDIOVASCULAR RISK  FACTOR. ENVIRON HEALTH PERSPECT.
                85: 1-13.

                BRENNIMAN. GR. PS LEVY  1984.  HIGH  BARIUM LEVELS IN PUBLIC DRINKING WATER AND ITS ASSOCIATION WITH ELEVATED BLOOD PRESSURE. IN: ADVANCES
                IN MODERN TOXICOLOGY IX.  EJ  CLALBRESE. ED  PRINCETON SCIENTIFIC PUBLICATIONS. PRINCETON. NJ.  P231-249

                US EPA.  1985  DRINKING WATER CRITERIA DOCUMENT FOR BARIUM.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF DRINKING WATER. WASHINGTON.  DC.  EXT REVIEW DRAFT. FINAL DRAFT (ON PUBLIC
                COMMENT). NTIS PB 86-118031/AS

                US EPA.  1990  RfD/RfC WORK GROUP

BARIUM CYANIDE                                              000542-62-1
        010941  US EPA.  1993. RfD/RfC WORK GROUP

BENEFIN                                                      001861-40-1
        005852  ELI LILLY AND CO  1972  CONFIDENTIAL BUSINESS INFORMATION,  UNPUBLISHED STUDY  MRID NO. 00037678.  AVAILABLE  FROM EPA. WRITE TO FOI.  EPA.
                WASHINGTON. DC 20460

                US EPA.  1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENEFIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA.  1985. RfD/RfC WORK GROUP.

BENZAL CHLORIDE                                            000098-87-3
        005853  US EPA   1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZAL CHLORIDE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.

BENZALDEHYDE                                                000100-52-7
        005854  KLUWE WM. CA MONTGOMERY.  HD GILES AND JD PREJEAU  1983.  ENCEPHALOPATHY IN RATS AND NEPHROPATHY IN RATS AND  MICE AFTER SUBCHRONIC ORAL
                EXPOSURE TO BENZALDEHYDE. FOOD CHEM TOXICOL  21(3): 245-250.

                US EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA.  1987. RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-10

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                                         REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER  THAN CARCINOGEN1CITY)                                              May 1995


BENZALDEHYDE CYANOHYDRIN                                 000532-28-5
        005781  US EPA.  1988.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR CYANOHYDRINS. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

BENZO[A]ANTHRACENE                                         000056-55-3
        010965  US EPA.  1994.  RfD/RfC WORK GROUP.

BENZENE                                                     000071-43-2
        010857  US EPA  1989.  RfD/RfC WORK GROUP.

BENZENETHIOL /  (THIOPHENOL)                              000108-98-5
        010942  AMERICAN BIOGENICS CORP. 1989.  NINETY-DAY GAVAGE STUDY IN ALBINO RATS USING THIOPHENOL.  PREPARED BY DYNAMAC CORP OF ROCKVILLE.  MD FOR THE
                US EPA OFFICE  OF SOLID WASTE.

                FAIRCHILD EJ AND HE STOKINGER  1958 TOXICOLOGIC STUDIES ON ORGANIC SULFUR COMPOUNDS.  1. ACUTE TOXICITY OF SOME ALIPHATIC AND AROMATIC
                THIOLS (MERCAPTANS). AM IND HYG ASSOC J  19: 171-189.

                US EPA.  1993.  RfD/RfC WORK GROUP.

BENZIDINE                                                  000092-87-5
        005830  LITTLEFIELD NA.  CJ NELSON AND CH FRITH. 1983  BENZIDINE  DIHYDROCHLORIDE- TOXICOLOGICAL ASSESSMENTS IN MICE DURING CHRONIC EXPOSURE.  J.
                TOXICOL. ENVIRON. HEALTH. 12: 671-685.

                US EPA.  1987.  RfD/RfC WORK GROUP.

        010877  US EPA.  1991.  RfD/RfC WORK GROUP.

BENZOIC ACID                                               000065-85-0
        005260  FDA (FOOD AND  DRUG ADMINISTRATION).  1973. EVALUATION OF  THE HEALTH ASPECTS OF BENZOIC ACID AND SODIUM BENZOATE AS FOOD  INGREDIENTS.  OHEW.
                WASHINGTON. DC.  REPORT NO. SCOGS-7 NTIS PB-223 837/6.  P.17.

                US EPA.  1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR BENZOIC ACID. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON,  DC.

                US EPA.  1987.  RfD/RfC WORK GROUP.
                                                                                                                                               Rl-11

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER  THAN  CARCINOGENICITY)                                              May 1995


BENZYL ALCOHOL                                             000100-51-6
        005855   NTP  (NATIONAL TOXICOLOGY PROGRAM).  1988  TOXICOLOGY AND  CARCINOGENESIS STUDIES OF BENZYL ALCOHOL  (CAS NO 100-51-6) IN F344/NRATS AND
                 B6C3F1 MICE (GAVAGE STUDIES)   NTP TECHNICAL REPORT. NTP  TR 343. P  1-161.

        005856   NTP  (NATIONAL TOXICOLOGY PROGRAM)   1988. TOXICOLOGY AND  CARCINOGENESIS STUDIES OF BENZYL ALCOHOL  (CAS NO 100-51-6) IN F344/NRATS AND
                 B6C3F1 MICE (GAVAGE STUDIES).  NTP TECHNICAL REPORT. NTP  TR 343. P  1-161.

                 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR BENZYL ALCOHOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

BERYLLIUH                                                   007440-41-7
        005262   SCHROEDER HA AND M MITCHNER.  1975   LIFE-TERM STUDIES IN  RATS:  EFFECTS OF ALUMINUM. BARIUM.  BERYLLIUM AND TUNGSTEN. J NUTR.  105:  421-427.

                 US EPA. 1991. DRINKING WATER  CRITERIA DOCUMENT FOR BERYLLIUM   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

                 US EPA. 1985. RfD/RfC WORK GROUP.

BIPHENYL,  1.1'                                             000092-52-4
        005857   AMBROSE AM. AN BOOTH. F DE EDS AND  AJ COS JR  1960  A TOXICOLOGICAL STUDY OF BIPHENYL.  A CITRUS FUNGISTAT. FOOD RES.  25:  328-336.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.1'-BIPHENYL  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA. 1985. RfD/RfC WORK GROUP.

        010878   US EPA. 1990. RfD/RfC WORK GROUP.

BIS(2-CHLOROISOPROPYL)  ETHER                            039638-32-9
        010257   MITSUMORI K. T USUI. K TAKAHASHI. AND Y SHIRASU. 1979. TWENTY-FOUR MONTH CHRONIC TOXICITY STUDIES OF DICHLORODIISOPROPYL  ETHER IN MICE
                 NIPPON NOYAKU GAKKAISHI. 4(3)- 323-335

                 US EPA. 1989. RfD/RfC WORK GROUP.
                                                                                                                                                Rl-12

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995



BIS(2-ETHYLHEXYL)  PHTHALATE   / (DEHP)                  000117-81-7
        010859  CARPENTER. CP.  CS WEIL AND HF SMYTH  1953  CHRONIC  ORAL TOXICITY OF DK2-ETHYLHEXYL)  PHTHALATE FOR RATS. GUINEA PIGS AND DOGS. ARCH IND
                HYG OCC MED.  8: 219-226.

                US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR  PHTHALIC ACID ESTERS.  PREPARED BY  THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
                OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

                US EPA. 1986. RfD/RfC WORK GROUP

BISPHENOL A                                                 000080-05-7
        005268  NTP (NATIONAL TOXICOLOGY PROGRAM)  1982.  CARCINOGENESIS BIOASSAY OF BISPHENOL A IN  F344 RATS AND B6C3F1 MICE (FEED STUDY)  NTP TECH REP
                SER. NO. 80-35 NTIS PB 84-1555308 P.  192.

                US EPA. 1988. RfD/RfC WORK GROUP.

        005266  NTP (NATIONAL TOXICOLOGY PROGRAM). 1982.  CARCINOGENESIS BIOASSAY OF BISPHENOL A IN  F344 RATS AND B6C3F1 MICE (FEED STUDY)  NTP TECH REP
                SER. NO. 80-35 NTIS PB 84-1555308 P  192

                US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BISPHENOL A.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

BORON TRIFLUORIDE                                          007637-07-2
        010395  RUSCH GM.  GM HOFFMAN. RF MCCONNELL ET AL.  1986.  INHALATION TOXICITY STUDIES WITH BORON TRIFLUORIDE. TOXICOL APPL PHARMACOL. 83: 69-78.

                US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BORON AND BORON COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON.  DC.
                                                                                                                                                Rl-13

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995



BORON. ELEMENTAL                                           007440-42-8
        005272  WEIR RJ. JR AND RS FISHER.  1972.  TOXICOLOGIC STUDIES ON BORAX AND BORIC ACID.  TOXICOL APPL  PHARMACOL. 23(3): 351-364.

                US EPA  1987  HEALTH EFFECTS ASSESSMENT FOR BORON AND COMPOUNDS.  PREPARED BY THE  OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA. 1989. RfD/RfC WORK GROUP.

                US EPA  1993  REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR  BORON. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR  THE OFFICE OF WATER. WASHINGTON. DC.

        005269  GARABRANT  DH. L BERNSTEIN.  JM PETERS ET AL. 1985. RESPIRATORY EFFECTS OF BORAX DUST.  BR J  IND MED. 42: 831-837.

                US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BORON AND BORON COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

BROMINATED DIBENZO-P-DIOXINS
        005858  US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE.  WASHINGTON. DC.

                US EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZOFURANS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

BROMINATED DIBENZOFURANS
        005859  US EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZOFURANS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE.  WASHINGTON. DC

BROMOACETONE                                                 000598-31-2
        005860  US EPA  1986  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOACETONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE. WASHINGTON. DC.
                                                                                                                                                  Rl-14

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN  CARCINOGENICITY)                                              Hay 1995


BROMOCHLOROETHANES
        005861   US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOCHLOROETHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

BROMODICHLOROMETHANE                                      000075-27-4
        005715   NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICITY AND CARCINOGENICITY STUDIES OF BROMODICHLOROMETHANE IN F344/N RATS AND B6C3F1 MICE
                 (GAVAGE STUDIES). NTP TECH REPORT. SER NO 321. NIH PUB NO 87-2537.

                 US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US  EPA. 1987. RfD/RfC WORK GROUP.

BROMOETHENE /  (VINYL BROMIDE)                            000593-60-2
        010929   BENYA TJ. WM BUSEY.  MA OORATO AND PE BERTEAU  1982.  INHALATION  CARCINOGENICITY BIOASSAY OF VINYL BROMIDE IN RATS. TOXICOL APPL PHARMACOL.
                 64(3): 367-379.

                 BUSEY WM. 1979. ONCOGENIC POTENTIAL OF VINYL BROMIDE DURING CHRONIC INHALATION EXPOSURE -- RATS: PATHOLOGY REPORT. EPA/OTS
                 8EHQ-0479-0281.

                 US  EPA. 1993. RfD/RfC WORK GROUP.

BROMOFORM                                                   000075-25-2
        005722   NTP (NATIONAL TOXICOLOGY PROGRAM)  1989  TOXICOLOGY AND CARCINOGENICITY STUDIES OF TRIBROMOMETHANE AND BROMOFORM  IN F344 RATS AND B6C3F1
                 MICE  (GAVAGE STUDIES).  NTP-350.

                 US  EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US  EPA. 1987. HEALTH AND ENVIRONMENTAL ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE  WASHINGTON.
                 DC.

                 US  EPA. 1987. RfD/RfC WORK GROUP.

        010961   US  EPA. 1993. RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-15

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                                          REFERENCES FOR HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)
                                                                                                                               May 1995
BROMOMETHANE
        010861
DANSE LH.  FL VAN VELSEN AND CA VAN DER HEIJDEN
PHARMACOL.  72-  262-271.
000074-83-9
 1984.  METHYL BROMIDE: CARCINOGENIC EFFECTS IN THE RAT FORESTOMACH.  TOXICOL APPL
                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR BROMOMETHANE. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC.

                US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL BROMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID HASTE AND  EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA.  1988. RfO/RfC WORK GROUP.

                US EPA.  1993. REVISED AND UPDATED  DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR BROMOMETHANE. PREPARED BY THE OFFICE OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR  THE OFFICE OF WATER. WASHINGTON. DC.

         010860  REUZEL.  PGJ. CF KUPER. HC DREEF-VAN  DER MEULEN. VMH HOLLANDERS. 1987. CHRONIC (29 MONTH) INHALATION TOXICITY AND CARCINOGENICITY STUDY OF
                METHYL BROMIDE IN RATS. REPORT NO  V86.469/221044. NETHERLANDS ORGANIZATION FOR APPLIED  SCIENTIFIC RESEARCH. DIVISION FOR NUTRITION AND
                FOOD RESEARCH. TNO. EPA/OTS DOCUMENT #86-8700001202.

                REUZEL.  PGJ. HC DREEF-VANDER MEULEN.  VMH HOLLANDERS. CF KUPER. VJ FERON.  CA VAN DER HEIJDEN.  1991. CHRONIC INHALATION TOXICITY AND
                CARCINOGENICITY STUDY OF METHYL BROMIDE IN WISTAR RATS. FOOD CHEM. TOXICOL. 29(1):  31-39.

                US EPA.  1991. RfD/RfC WORK GROUP.

BROMOPHENYL PHENYL  ETHER. 4-                             000101-55-3
         005864  US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-BROMOPHENYL  PHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

BROMOPHOS                                                   002104-96-3
         005865  LEUSCHNER F. A LEUSCHNER AND E POPPE 1967. CHRONISCHER REPROOUKTIONSVERSUCH UBER 3 GENERATIONEN AN WISTAR-RATTEN BEI FORTDAUERNER
                VERABREICHUNG VON BROMOPHOS. REPORT  CH BOEHRINGER SOHN. (UNPUBLISHED).

                US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOPHOS. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON. DC.
                                                                                                                                                  Rl-16

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                                          REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May  1995


BROMOXYNIL                                                  001689-84-5
         005866   UNION  CARBIDE AGRICULTURE PRODUCTS.  INC.  1982. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY  MRID NO  00096521  AVAILABLE FROM
                 EPA. WRITE TO FOI. EPA. WASHINGTON.  DC 20460

                 US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA.  1987. RfD/RfC WORK GROUP.

BROMOXYNIL OCTANOATE                                      001689-99-2
         005867   UNION  CARBIDE AGRICULTURE PRODUCTS.  INC.  1982. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY  MRID NO  00096521  AVAILABLE FROM
                 EPA. WRITE TO FOI. EPA. WASHINGTON.  DC 20460.

                 US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL OCTANOATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1987. RfD/RfC WORK GROUP.

BUSAN 77                                                        031512-74-0
         005868   US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 77.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

BUSAN 90                                                        002491-38-5
         005869   US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 90.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.'

BUTANOL.  1-                                                 000071-36-3
         005870   US EPA.  1986. BUTANOL:  RAT ORAL SUBCHRONIC TOXICITY STUDY.  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL-EFFECTS DOCUMENT FOR 1-BUTANOL.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA.  1986. RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-17

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN  CARCINOGENICITY)                                               May 1995



BUTYL BENZYL  PHTHALATE.  N-                               000085-68-7
        005616  NTP  (NATIONAL TOXICOLOGY PROGRAM)   1985  PROJECT NO 12307-02.  -03.  HAZELTON LABORATORIES AMERICA. INC.  UNPUBLISHED  STUDY.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC  ACID  ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON. DC.

                US EPA  1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS  (PAE)S. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF DRINKING WATER.  WASHINGTON. DC.

                US EPA  1989  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BUTYL BENZYL PHTHALATE. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

                US EPA. 1989. RfD/RfC WORK GROUP

BUTYLATE                                                    002008-41-5
        005871  STAUFFER CHEMICAL COMPANY. 1987. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO. 40289101. AVAILABLE FROM EPA. WRITE TO
                FOI.  EPA. WASHINGTON. DC 20460.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUTYLATE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA. 1989. RfD/RfC WORK GROUP.

BUTYLCHLORIDE.  T-                                          000507-20-0
        005810  US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

BUTYROLACTONE.  GAMMA-                                     000096-48-0
        005872  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUTYROLACTONE.  GAMMA. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

CACODYLIC ACID                                             000075-60-5
        005873  NEES PO.  1968. REPORT ON CACODYLIC ACID TOXICITY TO ANIMALS WISCONSIN ALUMNI RES FOUND. EPA PESTICIDE PETITION NO  OF 0911.

                US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CACODYLIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.


                                                                                                                                                  Rl-18

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                                           REFERENCES  FOR HEAST  TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995


CADMIUM                                                       007440-43-9
        005280   US EPA.  1985. DRINKING WATER CRITERIA DOCUMENT  ON CADMIUM. OFFICE OF DRINKING WATER.  WASHINGTON.  DC. FINAL DRAFT.

                 US EPA.  1980. AMBIENT WATER QUALITY  CRITERIA DOCUMENT FOR CADMIUM. PREPARED BY THE  OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER  REGULATIONS  AND STANDARDS. WASHINGTON.  DC.
                 EPA-440/5-80-025.

                 US EPA.  1988. RfD/RfC WORK GROUP.

CALCIUM  CYANIDE                                             000592-01-8
        010258   HOWARD JW AND RF HANZAL.  1955  CHRONIC TOXICITY FOR  RATS OF FOOD TREATED WITH HYDROGEN  CYANIDE. AGRIC FOOD CHEM. 3: 325-329.

                 PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND  RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS.  J
                 TOXICOL  ENVIRON HEALTH. 5: 579-592.

                 US EPA.  1985. RfD/RfC WORK GROUP.

CAPROLACTAM                                                  000105-60-2
        005284   SEROTA DG. AM HOBERMAN AND SC GAD. 1984. A THREE-GENERATION REPRODUCTION STUDY WITH CAPROLACTAM IN RATS. IN: PROCEEDINGS OF  A SYMPOSIUM
                 ON AN INDUSTRY APPROACH TO CHEMICAL  RISK ASSESSMENT: CAPROLACTAM AND RELATED COMPOUNDS  AS  A CASE  STUDY. INDUSTRY HEALTH FOUND ARLINGTON
                 VA.. P 191-204.

                 US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR CAPROLACTAM.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA.  1988. RfD/RfC WORK GROUP.

        005282   POWERS WJ. JR. JC PECKHAM. KM SIINO  AND SC GAD  1984. EFFECTS OF SUBCHRONIC DIETARY CAPROLACTAM ON RENAL FUNCTION. IN: PROCEEDINGS OF A
                 SYMPOSIUM ON AN INDUSTRY APPROACH TO CHEMICAL RISK ASSESSMENT: CAPROLACTAM AND RELATED  COMPOUNDS AS A CASE STUDY  INDUSTRY HEALTH FOUND
                 ARLINGTON. VA.

                 US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR CAPROLACTAM.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

        010966   US EPA.  1994. RfD/RfC WORK GROUP.
                                                                                                                                                  Rl-19

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                                           REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER  THAN CARCINOGENICITY)                                               May 1995


CAPTAFOL                                                     002425-06-1
         005874  ORTHO-CHEVRON CHEMICAL COMPANY. 1985. CONFIDENTIAL  BUSINESS INFORMATION. UNPUBLISHED STUDY ACCESSION  NO 260671  MRID NO  00149488
                 00155196.  AVAILABLE  FROM EPA. WRITE TO FOI.  EPA.  WASHINGTON. DC 20460.

                 US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAFOL. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.'

                 US EPA.  1987.  RFD/RFC WORK GROUP.

CAPTAN                                                        000133-06-2
         005875  CHEVRON  CHEMICAL  COMPANY. 1982. CONFIDENTIAL  BUSINESS INFORMATION. UNPUBLISHED STUDY.  MRID NO  00125293  AVAILABLE FROM EPA  WRITE TO
                 FOI.  EPA.  WASHINGTON. DC 20460.                                                                      '                   '

                 STAUFFER CHEMICAL COMPANY. 1982  CONFIDENTIAL  BUSINESS INFORMATION. UNPUBLISHED STUDY.  MRID NO  00120315  AVAILABLE FROM EPA  WRITE TO
                 FOI.  EPA.  WASHINGTON. DC 20460.                                                                       '                   '

                 US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAN. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US EPA.  1989.  RfD/RfC WORK GROUP

CARBARYL                                                     000063-25-2
         005876  CARPENTER  CP.  CW  WEIL.  PE POLIN.  ET AL  1961.  MAMMALIAN TOXICITY OF 1-NAPHTHYL-N-METHYLCARBAMATE (SEVIN INSECTICIDE).  J AGRIC  FOOD CHEM
                 9:  30-39.

                 US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBARYL.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.'

                 US EPA.  1985.  RfD/RfC WORK GROUP.

         010882  US EPA.  1991.  RfD/RfC WORK GROUP.

CARBOFURAN                                                   001563-66-2
         005877   FMC CORPORATION.  1983.  CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY.  ACCESSION NO 250740-250755 MRID NO 00129507  AVAILABLE
                 FROM  EPA. WRITE TO FOI.  EPA.  WASHINGTON. DC 20460.                                                    '         '           «wuuwi.t

                 US  EPA.  1984. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR CARBOFURAN.  PREPARED  BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.  '

                 US  EPA.  1987. RfD/RfC WORK GROUP.



                                                                                                                                                 Rl-20

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                                           REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                              May 1995


 CARBON DISULFIDE                                        000075-15-0
         010259  HARDIN BD.  GP BOND. MR SIKOR.  FD ANDREW. RP BELILES AND RW NIEMEIR.  1981. TESTING OF SELECTED WORKPLACE  CHEMICALS FOR TERATOGENIC
                 POTENTIAL.  SCAND J WORK ENVIRON  HEALTH   7CSUPPL 4): 66-75.

                 US EPA.  1985. RfD/RfC WORK GROUP.

         010430  TABACOVA S. LA HINKOVA. L BALABAEVA   1978  CARBON DISULFIDE TERATOGENICITY AND POSTNATAL EFFECTS IN  RATS. TOXICOL LETT.  2(3):  129-133.

                 TABACOVA S. B NIKIFOROV.  L BALABAEVA  1983  CARBON DISLUFIDE INTRAUTERINE SENSITIZATION. J APPL TOXICOL. 3(5): 233-239.

                 US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CARBON DISULFIDE. PREPARED BY THE  OFFICE  OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1989. RfD/RfC WORK GROUP.

CARBON  MONOXIDE                                            000630-05-0
         010493  REFER  TO APPENDIX A:  TECHNICAL INFORMATION. SECTION V  ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

CARBON  TETRACHLORIDE                                      000056-23-5
         010862  BRUCKNER. JV. WF MACKENZIE.  S MURALIDHARA.  ET AL.  1986.  ORAL TOXICITY OF CARBON TETRACHLORIDE-  ACUTE SUBACUTE AND SUBCHRONIC  STUDIES IN
                 RATS.  FUND APPL TOXICOL.  6(1): 16-34.

                 US EPA.  1985. RfD/RfC WORK GROUP

CHLORAL                                                     000075-87-6
         005290  SANDERS  VM. BM KAUFFMANN.  KL WHITE. JR  1982  TOXICOLOGY OF  CHLORAL HYDRATE IN THE MOUSE.  ENVIRON HEALTH PERSPECT.  44:  146-173.

                 US EPA.  1988.  HEALTH  AND  ENVIRONMENTAL EFFECTS DOCUMENT  FOR  CHLORAL. PREPARED BY THE  OFFICE OF  HEALTH AND ENVIRONMENTAL  ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE AND  EMERGENCY RESPONSE.  WASHINGTON. DC.'

                 US EPA.  1988.  RfD/RfC WORK GROUP

CHLORDANE                                                   000057-74-9
         005296   VELSICOL CHEMICAL CORP. 1983. ACC NO 252267.  MRID  NO.  00138591, 00144313.  AVAILABLE FROM EPA. WRITE TO FOI.  EPA,  WASHINGTON. DC 20460.

                 US  EPA.  1989.  RfD/RfC WORK GROUP.
                                                                                                                                                Rl-21

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                                          REFERENCES  FOR HEAST  TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995


CHLORINE  CYANIDE                                           000506-77-4
        010261  HOWARD JW AND RF HANZAL.  1955. CHRONIC TOXICITY FOR  RATS OF FOOD TREATED WITH  HYDROGEN CYANIDE.  AGRIC FOOD CHEM. 3: 325-329.

                PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND  RG THOMSON. 1979.  EFFECTS  OF  PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS.  J
                TOXICOL ENVIRON HEALTH  5- 579-592

                US EPA. 1985. RfD/RfC WORK GROUP

CHLORO-1.3-BUTADIENE. 2- /  (CHLOROPRENE)               000126-99-8
        010515  NTP (NATIONAL TOXICOLOGY PROGRAM)  1988  SUBCHRONIC  INHALATION TOXICITY STUDY  OF  CHLOROPRENE IN MICE AND RATS. CONDUCTED BY
                BATELLE PACIFIC NORTHWEST LABORATORY. HIGHLAND. WA

                US EPA. 1992. RfD/RfC WORK GROUP

CHLORO-M-CRESOL. P-                                       000059-50-7
        005366  MADSEN C. PH ANDERSEN. 0 MEYER AND G WURTZEN   1986   4-CHLORO-E-METHYLPHENOL: SALMONELLA/MAMMALIAN-MICROSOME MUTAGENICITY TEST AND
                SUBACUTE TOXICITY TEST IN RATS  BULL ENVIRON CONTAM  TOXICOL. 37(5): 651-654.

                US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR P-CHLORO-M-CRESOL   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.

CHLOROACETALDEHYDE                                        000107-20-0
        005342  US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROACETALOEHYDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.

CHLOROACETIC  ACID                                          000079-11-8
        005346  IRDC  (INTERNATIONAL RESEARCH AND  DEVELOPMENT CORPORATION). 1982. SUBCHRONIC ORAL  TOXICITY TEST WITH MONOCHLOROACETIC ACID IN RATS.
                NATIONAL TOXICOLOGY PROGRAM. BETHESDA. MD P 1-101.

                US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROACETIC ACID.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.

CHLOROANILINE.  2-                                          000095-51-2
        005347  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.



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                                           REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               Hay 1995



CHLOROANILINE. 3-                                          000108-42-9
         005348  US  EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.


CHLOROANILINE. 4-                                          000106-47-8
         005349  NCI  (NATIONAL CANCER INSTITUTE).  1979  BIOASSAY OF P-CHLOROANILINE FOR POSSIBLE CARCINOGENICITY  NCI CARC  TECH  REP  SER NO  189  NTIS
                 PB-295896.                                                                                                   '       •


                 US  EPA  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.

                 US  EPA.  1987. RfD/RfC WORK GROUP


CHLOROBENZENE                                              000108-90-7
         010863  MONSANTO COMPANY. 1967.  13-WEEK ORAL ADMINISTRATION--DOGS.  MONOCHLOROBENZENES. FINAL REPORT. PROJECT NO  241-105  FEBRUARY 24  PREPARED
                 BY  HAZELTON  LABORATORIES.


                 KNAPP. WK. WM BUSEY. AND W KUNDZINS 1971. SUBACUTE ORAL TOXICITY  OF MONOCHLOROBENZINE IN DOGS AND RATS  TOXICOL APPL PHARMACOL  19-  393
                 (ABSTRACT).


                 US  EPA.  1985. HEALTH ASSESSMENT DOCUMENT FOR CHLORINATED BENZENES.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. EPA  600/8-84-015F. NTIS PB85-150332.


                 US  EPA.  1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHOLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                 US  EPA.  1989. RfD/RfC WORK GROUP


CHLOROBENZILATE                                            000510-15-6
         010260   CIBA-GEIGY CORPORATION.  1984. MRID NO 00144691.  AVAILABLE FROM'EPA. WRITE TO FOI.  EPA.  WASHINGTON.  DC 20460.


                 US EPA.  1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CHLOROBENZILATE. PREPARED BY THE ENVIRONMENTAL  CRITERIA AND ASSESSMENT
                 OFFICE.  OFFICE OF HEATH AND ENVIRONMENTAL ASSESSMENT.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY  RESPONSE.

                 US EPA.  1989. RfD/RfC WORK GROUP

         010931   US EPA.  1993. RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-23

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                              May 1995



CHLOROBENZOIC ACID.  P-                                    000074-11-3
        005360   KIECKEBUSCH W. W GRIEM AND K LANG.  1960. THE TOLERABILITY OF P-CHLOROBENZOIC ACID. ARZNEIMI HEL-FORSCH.  10:  999-10001.

                 US EPA  1987  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR P-CHLOROBENZOIC ACID. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

CHLOROBENZOTRIFLUORIDE.  4-                               000098-56-6
        005364   HOOKER CHEMICAL CORP. 1981.  MODIFIED 90-DAY GAVAGE AND REPRODUCTION STUDY IN RATS PCBTF. CONDUCTED BY ELARS  BIORESEARCH LABORATORIES.
                 INC.  FORT COLLINS. CO. US EPA/OPTS PUBLIC FILES. MICROFICHE #OTS0508148.

                 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4-CHLOROBENZOTRIFLUORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

CHLOROBUTANE. 1-                                           000109-69-3
        005808   NTP  (NATIONAL TOXICOLOGY PROGRAM).  1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF N-BUTYL CHLORIDE IN F344/N RATS AND B6C3F1
                 MICE (GAVAGE STUDIES). CAS NO 109-69-3. NTP-TR-312. 198 P.

                 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

        005806   NTP  (NATIONAL TOXICOLOGY PROGRAM).  1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF N-BUTYL CHLORIDE IN F344/N RATS AND B6C3F1 MICE (GAVAGE
                 STUDIES). CAS NO  109-69-3. NTP-TR-312.  198 P.

                 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

CHLOROBUTANE. 2-                                           000078-86-4
         005809   US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

CHLOROCYCLOPENTADIENE                                     041851-50- 7
         005297   US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON. DC.



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                                           REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC  AND  CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)
                                                                                                                              Hay 1995
 CHLOROFORM                                                  000067-66-3
         005372  US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTIDIENES  PREPARED BY THE OFFICE  OF HEALTH AND
                 ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE.  WASHINGTON. DC.

 CHLOROMETHANE  (METHYL CHLORIDE)                          000074-87-3
         010005  US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL CHLORIDE.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASH!NGTON.  DC.

 CHLORONITROBENZENE.  M-                                    000121-73-3
         005879  US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITROBENZENES. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.                                                   ,
CHLOROPHENOL. 2-
         010436  EXON JH.  LD KOELLER.
                                              000095-57-8
                     1982.  EFFECTS OF TRANSPLACENTAL EXPOSURE TO CHLORINATED PHENOLS.  ENVIRON HEALTH PERSPECT. 46: 137-140.
CHLOROPHENOL,
        005309
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2.4-DICHLOROPHENOL.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
UL..


US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-CHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
WASHINGTON. DC.

US EPA. 1988. RfD/RfC WORK GROUP.


3-   .                                        000108-43-0
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
CHLOROPHENOL.  4-                                           000106-48-9
        005310   US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                                                                                                                                                 Rl-25

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               Hay 1995
                WASHINGTON. DC.
CHLOROPROPANE   2-                                          000075-29-6
        010444  GAGE JC. 1970. THE SUBACUTE INHALATION TOXICITY OF 109 INDUSTRIAL CHEMICALS. BR J IND MED.  27(1):  1-18.

                US EPA  1987  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2 -CHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

f HI OROTHALON I L                                               00 1897 - 45 - 6
        005883  DIAMOND SHAMROCK CHEMICAL COMPANY.  1970. CONFIDENTIAL BUSINESS  INFORMATION. UNPUBLISHED STUDY.  ACCESSION NO 111253. MRID NO.  00057702.
                00114034. AVAILABLE FROM EPA.  WRITE  TO FOI . EPA. WASHINGTON. DC 20460.

                US  EPA  1986. RfD/RfC WORK GROUP.

PHI OROTOI UENE  M -                                          000108 - 41 - 8
        005880   US  EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROTOLUENES .  PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.


PHI OROTOLUENE  0-                                          000095-49-8
         010167   GIBSON  WR   FO GOSSETT  GR KOENIG  F MARROQUIN.  1974. THE TOXICITY OF DAILY ORAL DOSES OF 0-CHLOROTOLUENE  IN THE RAT. TOXICOLOGY
         010167       ™WR                            SUBMITTED T0 TEST RULES DEVELOPMENT BRANCH. OFFICE OF TOXIC SUBSTANCES. US EPA. WASHINGTON.  DC.
                 US EPA.  1989.  RfD/RfC WORK GROUP.

 PHI OROTOI UENE   P-                                          000106-43-4
         010200  'US EPA  1985  HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR CHOROTOLUENES .  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.


 CHLORPYRIFOS                                                002921-88-2
         005881  DOW CHEMICAL COMPANY.  1972. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. ACCESSION NO 112118.

                 US EPA  1984  HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR CHLORPYRIFOS AND CHLOROPYRIFOS-METHYL. PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON,  DC.

                 US EPA. 1986. RfD/RfC  WORK GROUP.
                                                                                                                                                  Rl-26

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                                          REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                              Hay 1995


CHLORPYRIFOS METHYL                                       005598-13-0
         005882  US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORPYRIFOS AND  CHLORPYRIFOS-METHYL  PREPARED BY THE  OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON. DC.

CHLORTHIOPHOS                                              060238-56-4
         005884  WORTHING CR AND SB WALKER.  ED.  1983. THE PESTICIDE MANUAL. 7TH ED.  BRITISH CROP PROTECTION COUNCIL.  THE  LAVENHAM  PRESS LTD  SUFFOLK
                 ENGLAND. P 130.

                 US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORTHIOPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHROMIUM(III)                                              016065-83-1
         005731  IVANKOVIC S AND R PREUSSMAN.  1975  ABSENCE OF TOXIC AND CARCINOGENIC EFFECTS AFTER ADMINISTRATIONS OF HIGH DOSES  OF CHROMIC OXIDE PIGMENT
                 IN SUBACUTE AND LONG-TERM FEEDING  EXPERIMENTS IN RATS. FOOD COSMET  TOXICOL   13: 347-351.

                 US EPA.  1984. HEALTH EFFECTS  ASSESSMENT  FOR TRIVALENT CHROMIUM.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA.  1986. RfD/RfC WORK GROUP.

CHROMIUM(VI)                                               018540-29-9
         005522  MACKENZIE RD. RU BYERRUM.  CF  DECKER ET AL. 1958.  CHRONIC TOXICITY STUDIES. II. HEXAVALENT AND TRIVALENT  CHROMIUM  ADMINISTERED IN DRINKING
                 WATER TO RATS. AM MED ASSOC ARCH IND HEALTH  18  232-234.

                 US EPA.  1984. HEALTH EFFECTS  ASSESSMENT  FOR HEXAVALENT CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA.  1986. RfD/RfC WORK GROUP.

CHRYSENE                                                     000218-01-9
         005885  US EPA   1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHRYSENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.'

COPPER                                                       007440-50-8
         005374   US EPA.  1987. DRINKING WATER  CRITERIA DOCUMENT FOR COPPER.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF DRINKING WATER.  WASHINGTON.  DC.
                                                                                                                                                 Rl-27

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                                         REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995


COPPER CYANIDE                                             000544-92-3
        010262  US EPA.  1986.  90 DAY ORAL TOXICITY  STUDY OF COPPER CYANIDE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA.  1987.  RfD/RfC WORK GROUP.

CRESOL. M-  /  (3-METHYLPHENOL)                           000108-39-4
        005380  US EPA.  1986.  O.M.P-CRESOL.  90-DAY  ORAL SUBCHRONIC TOXICITY STUDIES IN RATS  OFFICE OF SOLID WASTE. WASHINGTON. DC.

                US EPA.  1987.  O.M.P-CRESOL.  90-DAY  ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS.  OFFICE OF SOLID WASTE.  WASHINGTON. DC.

                US EPA.  1987.  RfD/RfC WORK GROUP.

        010888  US EPA.  1991.  RfD/RfC WORK GROUP.

CRESOL. 0-  /  (2-METHYLPHENOL)                           000095-48-7
        005384  US EPA.  1986.  O.M.P-CRESOL.  90-DAY  ORAL SUBCHRONIC TOXICITY STUDIES IN RATS. OFFICE OF SOLID WASTE. WASHINGTON. DC.

                US EPA.  1987.  O.M.P-CRESOL.  90-DAY  ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS.  OFFICE OF SOLID WASTE.  WASHINGTON. DC.

                US EPA.  1987.  RfD/RfC WORK GROUP.

        010889  US EPA.  1991.  RfD/RfC WORK GROUP.

CRESOL. P-  /  (4-METHYLPHENOL)                           000106-44-5
        010516  CMA (CHEMICAL  MANUFACTURERS' ASSOCIATION).  1988. DEVELOPMENTAL TOXICITY EVALUATION OF 0-. M- OR P-CRESOL ADMINISTERED BY GAVAGE TO NEW
                ZEALAND WHITE  RABBITS. FINAL PROJECT REPORT 51-508. FICHE NO. OTS0517695.

                DEITZ D. AND LT MULLIGAN. 1988.  SUBCHRONIC TOXICITY OF P-CRESOL  IN SPRAGUE-DAWLEY RATS: MBA CHEMICAL NO 25.  PREPARED BY RESEARCH TRIANGLE
                INSTITUTE.  RESEARCH TRIANGLE PARK.  NC. PREPARED FOR EPA.  WASHINGTON. DC.

                US EPA.  1993.  RfD/RfC WORK GROUP.

        010890  US EPA.  1991.  RfD/RfC WORK GROUP.
                                                                                                                                               Rl-28

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                                           REFERENCES FOR HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC TOXICITY
                                                                (OTHER THAN CARCINOGENICITY)                                               Hay 1995


CUMENE                                                       000098-82-8,
         005392  WOLF MA. VK ROME,  DO MCCOLLISTER. RL HOLLINGSWORTH AND F OYEN. 1956.  TOXICOLOGICAL  STUDIES OF CERTAIN ALKYLATED BENZENE AND BENZENES AHA
                 ARCH IND HEALTH.  14:  387-398.

                 US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CUMENE.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA. 1987.  RfD/RfC WORK GROUP.

         005908  MONSANTO COMPANY.  1986. ONE MONTH STUDY OF CUMENE VAPOR ADMINISTERED TO MALE AND FEMALE SPRAGUE-DAWLEY RATS BY INHALATION  US EPA/OTS
                 PUBLIC FILES.  8D  SUBMISSION. MICROFICHE* OTS 0513229.

                 US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CUMENE.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

CYANAZINE                                                    021725-46-2
         010411  El DU PONT DE  NEMOURS AND COMPANY. INC. 1986. CONFIDENTIAL BUSINESS  INFORMATION.  UNPUBLISHED STUDY  MRID NO  40081901 AND 40229001
                 AVAILABLE FROM EPA.  WRITE TO FOI. EPA. WASHINGTON.  DC  20460.

                 US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYANAZINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE  OF SOLID WASTE. WASHINGTON. DC.

                 US EPA. 1992.  RfO/RfC WORK GROUP.

                 US EPA. 1993.  REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR CYANAZINE. PREPARED BY THE OFFICE OF HEALTH
                 AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON.  DC.

CYANIDE                                                      000057-12-5
         005396  HOWARD JW AND  RF HANZAL. 1955.  CHRONIC TOXICITY FOR RATS OF  FOOD TREATED WITH  HYDROGEN CYANIDE. J AGRIC FOOD CHEM. 3: 325-329.

                 US EPA. 1984.  HEALTH  EFFECTS ASSESSMENT FOR CYANIDE. PREPARED BY THE  OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR  THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA.  1991.  DRINKING WATER CRITERIA DOCUMENT FOR  CYANIDE.  PREPARED  BY  THE  OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR  THE OFFICE OF DRINKING WATER.  WASHINGTON. DC.

                 US EPA.  1985.  RfD/RfC WORK GROUP.
                                                                                                                                                   Rl-29

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                                          REFERENCES FOR  HEAST  TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              Hay 1995



CYANOGEN                                                     000460-19-5
        010263  HOWARD JW AND RF HANZAL.  1955. CHRONIC TOXICITY FOR  RATS OF FOOD TREATED WITH  HYDROGEN CYANIDE  AGRIC FOOD CHEM.  3:  325-329.

                US EPA. 1985. RfD/RfC WORK GROUP.

CYANOGEN  BROMIDE                                           000506-68-3
        010264  HOWARD JW AND RF HANZAL.  1955. CHRONIC TOXICITY FOR  RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM.  3:  325-329.

                US EPA. 1987. RfD/RfC WORK GROUP.

CYCLOATE                                                     001134-23-2
        005886  US EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOATE. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON,  DC.


CYCLOHEXANOL                                                000108-93-0
        005887  US EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOHEXANOL  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON.  OC.


CYCLOHEXYLAMINE                                            000108-91-8
         005400  GAUNT IF. J HARDY. P GRASSO. SD  GANGOLLI AND KR BUTTERWORTH   1976.  LONG-TERM TOXICITY OF CYCLOHEXYLAMINE HYDROCHLOR1DE IN THE RAT.  FOOD
                COSMET TOXICOL.  14(4): 255-268.

                US EPA 1987  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CYCLOHEXYLAMINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA"AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID  WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON.  DC.

                 US EPA. 1987. RfD/RfC WORK GROUP.

         005398  GAUNT IF. M  SHARRATT. PG GRASSO. AB LANSDOWN AND SD GANGOLLI   1974  SHORT-TERM TOXICITY OF CYCLOHEXYLAMINE  HCL IN THE RAT. FOOD COSMET
                TOXICOL.  12:  609-624.

                 US EPA  1987 HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR  THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.
                 WASHINGTON.  DC.
                                                                                                                                                  Rl-30

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGEN1CITY)                                              May 1995


CYCLOPENTADIENE                                            000542-92-7
         010494   DOW.  1987. UNPUBLISHED DATA. DOW CHEMICAL  USA. MIDLAND. MI.

                 US  EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE  AND DICYCLOPENTADIENE  PREPARED BY THE  OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON,  DC.

DACTHAL                                                     001861-32-1
         005888   ISK BIOTECH CORPORATION.  1993. MRID NO. 42731001.  42998401. HED DOC NO 010513  AVAILABLE FROM EPA  WRITE TO FOI  EPA  WASHINGTON  DC
                 20460.

                 US  EPA. 1994. RfD/RfC WORK GROUP.


DALAPON                                                     000075-99-0
         005889   PAYNTER OE. TW TUSING.  DD MCCOLLISTER AND VK ROWE.  1960. TOXICOLOGY OF DALAPON SODIUM (2 2-DICHLOROPROPIONIC ACID  SODIUM SALT)  J AGRIC
                 FOOD CHEM. 8: 47-51.

                 US  EPA. 1984. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR DALAPON. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US  EPA. 1988. RfD/RfC WORK GROUP.

DOT                                                          000050-29-3
         005408   LAUG.  EP.  AA NELSON.  OG FITZHUGH AND FM KUNZE.  1950. LIVER CELL ALTERATION AND DDT STORAGE IN THE FAT OF THE RAT INDUCED BY DIETARY
                 LEVELS OF 1-50 PPM DDT. J  PHARMACOL EXP THERAP. 98: 268-273.

                 US  EPA. 1985. RfD/RfC WORK GROUP.
                                                                                                                                                Rl-31

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995


DECABROHODIPHENYL ETHER                                  001163-19-5
        005891   KOCIBA RJ. LO FRAUSON. CG HUMISTON.  ET AL. 1975. RESULTS OF A TWO-YEAR DIETARY FEEDING STUDY WITH DECABROMODIPHENYL OXIDE  (DCDPO) IN
                 RATS. COMBUST TOXICOL. 2(4):  267-285.

                 MORRIS JM. JW EHRMANTRAUT. a GIBBONS. ET AL. 1975. TOXICOLOGY OF  OCTABROMOBIPHENYL AND OECABROMODIPHENYL OXIDE.  ENVIRON HEALTH PERSPECT.
                 11:153-161.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA. 1985. RfD/RfC WORK GROUP.

DI-N-OCTYL PHTHALATE                                      000117-84-0
        010275   PIEKACZ H. 1971. EFFECT OF DIOCTYL AND DIBUTYL PHTHALATES ON THE ORGANISM OF RATS AFTER ORAL ADMINISTRATION IN PROLONGED EXPERIMENT. II
                 SUBACUTE AND CHRONIC TOXICITY. ROCZ  PANSTW ZAKL HIG. 22(3):  295-307.

                 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACID. ALKYL. ARYL. AND ALKYL/ARYL ESTERS.  PREPARED BY  THE OFFICE OF
                 HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE.
                 WASHINGTON. DC.

DIAZINON                                                     000333-41-5
        005892   DAVIES DB AND BJ HOLUB. 1979.  COMPARATIVE SUSCEPTIBILITY OF MALE AND FEMALE RATS TO DIETARY DIAZINON TOXICITY.  J NUTR. 109(6): XXVIII.

                 DAVIES DB AND BJ HOLUB. 1980.  COMPARATIVE SUBACUTE TOXICITY OF  DIETARY DIAZINON IN THE MALE AND FEMALE RAT.  TOXICOL APPL PHARMACOL
                 54(3): 359-367.

                 DAVIES DB AND BJ HOLUB. 1980.  TOXICOLOGICAL EVALUATION OF DIETARY  DIAZINON IN THE RAT. ARCH ENVIRON CONTAM TOXICOL. 9(6).  637-650.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIAZINON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.

DIBENZOFURAN                                                000132-64-9
        005409   US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DIBENZOFURAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON.  DC.
                                                                                                                                                 Rl-32

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                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995


DIBROHOBENZENE.  1.4-                                       000106-37-6
        005893  CARLSON GP AND RG TARDIFF. 1977. EFFECT OF 1.4-DIBROMOBENZENE AND 1.2.4-TRIBROMOBENZENE ON  XENOBIOTIC METABOLISM.  TOXICOL APPL  PHARMACOL.
                42(1): 189-196.

                US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR BROMOBENZENES.  PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                US EPA. 1986.  RfD/RfC WORK GROUP.

DIBROMOCHLOROMETHANE                                      000124-48-1
        005894  NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY  AND CARCINOGENESIS STUDIES OF CHLORODIBROMOMETHANE IN F344/N RATS AND B6C3F1  MICE
                (GAVAGE STUDIES). NTP TR282. NTIS PB86-166675.

                US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR BROMOCHLOROMETHANES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR DIBROMOCHLOROMETHANE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1987.  RfD/RfC WORK GROUP.

DIBRONOETHANE.  1.2-                                        000106-93-4
        010854  RATCLIFFE JM.  SM SCHRADER. K STEENLAND.  DE CLAPP.  T  TURNER AND RW HORNUNG. 1987. SEMEN QUALITY  IN PAPAYA WORKERS WITH LONG-TERM EXPOSURE
                TO ETHYLENE BROMIDE. BR J  IND MED. 44: 317-326.

                SCHRADER SM. TW TURNER AND JM RATCLIFFE. 1988.  THE EFFECTS OF ETHYLENE BROMIDE ON SEMEN QUALITY: A  COMPARISON OF SHORT-TERM AND CHRONIC
                EXPOSURE. REPROD TOXICOLOGY. 2:  191-198.

                US EPA. 1992.  RFD/RFC WORK GROUP.
                                                                                                                                                 Rl-33

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                                                              (OTHER  THAN CARCINOGEN I CITY)                                             ^ 1995


 DIBUTYL PHTHALATE                                        000084-74-2
         005622  SMITH  CC. 1953. TOXICITY OF BUTYL STEARATE. DIBUTYL SEBACATE. DIBUTYL PHTHALATE AND METHOXYETHYL OLEATE  ARCH HYG OCCUP MED  7  310-318

                 US EPA. 1990.  RfD/RfC WORK GROUP.

         010892   US EPA. 1990.  RfD/RfC WORK GROUP.

 DICAMBA                                                    001918-00-9
         010945
                CITED A5 VELSICOL CHEMICAL CORPORATION (1978)  IN U.S. EPA (1993). MRID 00028236. AVAILABLE FRo  EA WR    TO Si   E?A. LsS?S  DC
                US EPA.  1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC  EFFECTS FOR DICAMBA  PRFPARFn RY THF OFPTPF nr u«i TU
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  cST!« TO THE^ICE OF^ra  2sH?NGTON. Sc
                US EPA.  1988. RfD/RfC WORK GROUP.

DICHLOROBENZENE.  1.2-                                    000095-50-1
        010864  US EPA.  1989. RfD/RfC WORK GROUP.


DICHLOROBENZENE,  1.3-                                    000541-73-1
        005414  US EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR DICHLOROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE

                US EPA.  1992. RfD/RfC WORK GROUP.
                                                                                                                                            Rl-34

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995



DICHLOROBENZENE. 1.4-                                     000106-46-7
        010840  CHLOROBENZENE PRODUCERS ASSN. 1986. PARADICHLOROBENZENE: TWO-GENERATION REPRODUCTION STUDY IN  SPRAGUE-DAWLEY RATS. STUDY N086-81-90605.
                MRID NO 411088-1.  AVAILABLE FROM EPA. WRITE TO FOI.  EPA. WASHINGTON. DC 20460.

                NTP (NATIONAL TOXICOLOGY  PROGRAM). 1987. TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.4-DICHLOROBENZENE  IN F344/N RATS AND 86C3F1 MICE
                (GAVAGE STUDIES).  NTP TR  319. NIH PUBL NO 87-2575.

                US EPA. 1992. RfD/RfC WORK GROUP.

OICHLOROBUTENES
        005415  US EPA. 1987. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR DICHLOROBUTENES  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.

DICHLORODIFLUOROMETHANE                                  000075-71-8
        005498  SHERMAN H.  1974. LONG-TERM FEEDING STUDIES IN RATS AND DOGS WITH DICHLORODIFLUOROMETHANE (FREON 12 FOOD FREEZANT)  HASKELL LABORATORY
                REPORT NO 24-74. UNPUBLISHED. COURTESY DU PONT DE NEMOURS  CO.

                US EPA. 1987  HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC

                US EPA. 1985. RfD/RfC WORK GROUP.

        005496  CLAYTON WJ. JR. 1967. FLUOROCARBON TOXICITY AND BIOLOGICAL ACTION.  FLUORINE CHEM REV. 1(2). 197-252.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC

DICHLOROETHANE, 1.1-                                      000075-34-3
        005790  HOFMANN HT. H BIRNSTIEL AND P JOBST. 1971. ON THE INHALATION TOXICITY OF  1.1- AND  1.2-DICHLOROETHANE.  ARCH  TOXIKOL.  27:  248-265.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHANE   PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC.
                                                                                                                                                  Rl-35

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                                        REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                          (OTHER  THAN CARCINOGENICITY)                                          May 1995

 DICHLOROETHYLENE.  1.1-                                 000075-35-4
        005419                                                 '     ™ m oraaicnv STUOY IN ™ « SUBCHRONIC TOXICITY S™Y IN
                            »c     HEALTH EFFKTS A551155^7 FOR LI -DICHLOROETHYLENE (VINYLIDINE CHLORIDE). PREPARED BY THE OFFICE OF HEALTH AND
                           r     SMENT> ENVIRONMENTAL CRITERIA A"0 ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE
                         . DC.
                US EPA.  1989. RfD/RfC WORK GROUP.

 DICHLOROETHYLENE. 1.2-  (MIXED ISOMERS)               000540-59-0
        010509                                 T              "1^ " oraaicnY STUDY IN "ws m SUBCHRONIC  TOXICITY STUOY I
               US EPA.  1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.2-DICHLOROETHYLENE  (MIXED ISOMERS)  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE . WASH I NGTON . DC .
DICHLOKOETHYLBIE. 1.2-C-                              000156-59-2
        005420                                        """™ "^ " *KmaiK ^ amm ™"s-'-"«««™™ ••
               US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR 1.2-C-DICHLOROETHYLENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
               ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REM^IAiTsPONSE^HINGTON  ^

               US EPA. 1990.  RfD/RfC WORK GROUP.

DICHLOROETHYLENE.  1.2-T-                               000156-60-5
        005895  BARNES DW. MM  SANDERS.  KL SHITE JR. ET AL. 1985.  TOXICOLOGY OF TRANS- 1.2-DICHLOROETHYLENE IN THE MOUSE.  DRUG CHEM TOXICOL. 8: 373-392.

               US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR 1.2-T-DICHLOROETHYLENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
               ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE^ASHINGTON  DC

DICHLOROPHENOL.  2.3-                                    000576-24-9
        005315  US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE™
               WASH I NGTON ,  DC .
                                                                                                                                     Rl-36

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                                          REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995



DICHLOROPHENOL.  2.4-                                       000120-83-2
        005314  EXON JH.  AND LD KOLLER.  1985. TOXICITY OF 2-CHLOROPHENOL.2.4-OICHLOROPHENOL AND 2.4.6-TRICHLOROPHENOL.  IN: WATER CHLORINATION:  CHEM.
                ENVIRON IMPACT AND HEALTH  EFF. JOLLEY ET AL..  ED. VOL. 5.

                US EPA  1987  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2.4-DICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON.
                DC.

                US EPA. 1986. RfD/RfC  WORK GROUP.

DICHLOROPHENOL.  2.5-                                       000583-78-8
        005316  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

DICHLOROPHENOL.  2.6-                                       000087-65-0
        005317  US EPA. 1987  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1988. RfD/RfC  WORK GROUP.

DICHLOROPHENOL.  3.4-                                       000095-77-2
        005318  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

DICHLOROPHENOL.  3.5-                                       000591-35-5
        005319  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

DICHLOROPHENOXY ACETIC ACID.  2.4-                       000094-75-7
        010265  DOW CHEMICAL CO. 1983. ACC NO. 251473.

                US EPA. 1988. RfD/RfC  WORK GROUP.


                                                                                                                                                 Rl-37

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                                          REFERENCES FOR  HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995


DICHLOROPHENOXY) BUTYRIC ACID.  4-(2.4- /  (2.4-DB)     000094-82-6
        005890  RHOOIA INC. 1969.  CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRIO NO. 0092165  AVAILABLE  FROM EPA  WRITE TO FOI   EPA
                WASHINGTON, DC 20460.

                US EPA. 1984. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-DB.  PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DICHLOROPROPANE. 1.1-                                    000078-99-9
        005897  US EPA. 1985. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

DICHLOROPROPANE. 1.2-                                    000078-87-5
        005898  NITSCHKE KD. KA JOHNSON.  DL WACKERLE.  JE PHILLIPS. DA DITTENBER.  1988. PROPYLENE DICHLORIDE:  A 13 WEEK INHALATION TOXICITY  STUDY WITH
                RATS.  MICE AND RABBITS.  DOW CHEMICAL CO. MAMMALIAN AND ENVIRONMENTAL TOXICOLOGY RESEARCH LABORATORY. MIDLAND. MI.

                US EPA. 1985. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

                US EPA. 1991. RfD/RfC WORK GROUP.

DICHLOROPROPANE. 1.3-                                    000142-28-9
        005899  US EPA. 1985. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES  PREPARED BY THE  OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

DICHLOROPROPANE. 2.2-                                    000594-20-7
        005900  US EPA. 1985. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES  PREPARED BY THE  OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.
                                                                                                                                               Rl-38

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                                          REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGEN1CITY)                                               May 1995


DICHLOROPROPENE.  1.3-  / (TELONE  II)                    000542-75-6
         005901   DOW CHEMICAL CO. 1973. MRID NOS.  00067977.  0039684. AVAILABLE FROM EPA.  WRITE  TO FOI. EPA. WASHINGTON. DC 20460.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR 1.3-OICHLOROPROPENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA.  1987. RfD/RfC WORK GROUP.

                 US EPA.  1993. REVISED AND UPDATED DRINKING  WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR 1.3-DICHLOROPROPENE.  PREPARED BY  THE OFFICE OF
                 HEALTH AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON,
                 DC.

         010351   LOMAX. LG.  WT STOTT. KA JOHNSON.  ET AL.  1989. THE CHRONIC TOXICITY AND ONCOGENICITY OF INHALED TECHNICAL-GRADE 1.3-DICHLOROPROPENE IN
                 RATS AND MICE. FUND APPL TOXICOL.  10: 214.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR 1.3-DICHLOROPROPENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA.  1990. RfD/RfC WORK GROUP.

DICHLORPROP                                                 000120-36-5
         005896   US EPA.  1984. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR DICHLOROPROP. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DICYCLOPENTADIENE                                         000077-73-6
         005425   LITTON BIONETICS. INC. 1980.  MAMMALIAN  TOXICOLOGICAL EVALUATION OF DIMP AND DCPD.  (PHASE 2). LITTON BIONETICS. INC.. KENSINGTON.  MD
                 CONTRACT DAMB. 17-77-C-7003.  NTIS AD-A082685

                 US EPA.  1987. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE  PREPARED BY THE OFFICE OF HEALTH  AND
                 ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE.  WASHINGTON. DC.

DIELDRIN                                                    000060-57-1
         005429   WALKER AIT. DE STEVENSON. J ROBINSON. ET AL. 1969. THE TOXICOLOGY AND PHARMACODYNAMICS OF DIELDRIN (HEOD): TWO-YEAR ORAL EXPOSURE OF RATS
                 AND DOGS.  TOXICOL APPL PHARMACOL.  15: 345-373.

                 US EPA.  1987. RfD/RfC WORK GROUP.
                                                                                                                                                  Rl-39

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                                           REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                              May 1995


 DIETHYL PHTHALATE                                         000084-66-2
         005620  BROWN D.  KR BUTTERWORTH. IF GAUNT ET AL. 1978. SHORT-TERMORAL TOXICITY STUDY OF DIETHYL PHTHALATE  IN THE RAT  FOOD COSMET TOXICOL   16
                 415-422.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR SELECTED PHTHALIC ACID ESTERS. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL  ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND  REMEDIAL RESPONSE  WAS™ON  DC
                     rnrrn™       CRITERIA ^^ FOR PHTHALIC *W ESTERS (PAE)S  PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
                 OFFICE. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  CINCINNATI. OH. FOR THE OFFICE OF DRINKING WATER. WASHINGTON.  DC.

                 US  EPA. 1987. RfD/RfC WORK GROUP.

DIETHYL-P-NITROPHENYL  PHOSPHATE                         000311-45-5
         005922   US  EPAJ989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIETHYL-P-NITROPHENYL PHOSPHATE. PREPARED BY THE OFFICE OF HEALTH AND
                                       J-  ENVIRONMENTAL CRITERIA A*0 ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE  AND  EMERGENCY
                                    .  DC.
DIETHYLANILINE. N,N-                                      000091-66-7
         005903  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIETHYLANILINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WAjn 1 Nu I UN . DC .

DIETHYLENE 6LYCOL MONOBUTYL ETHER                       000112-34-5
         005482  US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE  WASHINGTO? DC  EPASw! To52

                US EPA. 1992. RfD/RfC WORK GROUP.

DIETHYLENE GLYCOL MONOETHYL ETHER                       000111-90-0
         005478  SMYTH HF.  CP CARPENTER AND CB SHAFFER.  1964. A 2-YEAR STUDY OF DIETHYLENE GLYCOL  MONOETHYL ETHER IN RATS  FOOD  COSMET TOXICOL  2-
                641-642.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAI
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONS^WASHINGm  DC  EP^!/! 86  052

        005476  HALL DE. FS LEE.  P AUSTIN AND FA FAIRWEATHER.  1966. SHORT-TERM FEEDING STUDY WITH DIETHYLENE GLYCOL MONOETHYL ETHER  IN RATS  FOOD  COSMET
                IOXICOL. 4: 263.

                US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON  DC !  EPA MO/lToK



                                                                                                                                                Rl-40

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995



DIETHYLFORHAMIDE                                           000617-84-5
        010437  ARGUS MF. JC ARCOS AND C HOCH-LIGETI. 1965. THE CARCINOGENIC ACTIVITY OF PROTEIN-DENATURING AGENTS: HEPATOCARCINOGENICITY OF DIOXANE. J.
                NATL CANCER INST.  35:  949-958.

                US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIETHYLFORMAMIDE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

DIETHYLHYDRAZINE.  1.2-                                    001615-80-1
        005921  US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2-DIETHYLHYDRAZINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

DIMETHOATE                                                  000060-51-5
        005923  AMERICAN CYANAMID COMPANY. 1986. MRID NO 00164177   AVAILABLE FROM EPA  WRITE TO FOI. EPA. WASHINGTON.  DC 20460.

                US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHOATE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA. 1988.  RfD/RfC  WORK GROUP.

DIMETHYLANILINE. N.N-                                     000121-69-7
        005924  ABOO K. M WOLFE  AND R  HILES. 1984. SUBCHRONIC TOXICITY OF N.N-DIMETHYLANILINE  TO F-344 RATS AND B6C3F1 MICE.  FED PROC  43(3). 1698

                US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.
                                                                                                                                                Rl-41

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC  AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995


DIMETHYLFORMAMIOE.  N.N-                                   000068-12-2
        005925  BECCI. PJ. KA VOSS.  WD JOHNSON. ET AL. 1983.  SUBCHRONIC FEEDING STUDY OF N.N-DIMETHYLFORMAMIDE IN RATS AND MICE.  J  AM  COLL TOXICOL. 2(6):
                371-378.

                US EPA  1986  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLFORMAMIDE.  PREPARED  BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH, FOR THE  OFFICE  OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

        010352  CIRLA. AM. G PISATI. E INVERNIZZI ET AL. 1984. EPIDEMIOLOGICAL STUDY ON WORKERS EXPOSED TO  LOW DIMETHYLFORMAMIDE CONCENTRATIONS. G ITAL
                MED LAV. 6: 149-156.

                CATENACCI. G. D GRAMPELLA.  R TERZI. ET AL  1984.  HEPATIC  FUNCTION IN SUBJECTS EXPOSED TO  ENVIRONMENTAL CONCENTRATIONS  OF  DMF LOWER THAN
                THE ACTUALLY PROPOSED TLV.  G ITAL MED LAV. 6: 157-158.

                US EPA. 1990. RfD/RfC WORK GROUP.

DIMETHYLPHENOL. 2.3-                                      000526-75-0
        005926  US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

DIMETHYLPHENOL. 2.4-                                      000105-67-9
        010266  US EPA. 1989. NINETY-DAY GAVAGE STUDY  IN ALBINO MICE USING 2.4-DIMETHYLPHENOL  STUDY 410-2831. PREPARED BY DYNAMAC  CORPORATION.
                ROCKVILLE. MD. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA  1986  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH, FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

                US EPA. 1990. RfD/RfC WORK GROUP.

DIMETHYLPHENOL. 2.5-                                      000095-87-4
        005928  US EPA  1986  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.
                                                                                                                                                 Rl-42

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER  THAN CARCINOGEN 1C ITY)                                              May  1995


 DIMETHYLPHENOL.  2,6-                                      000576-26-1
         005431  VELDRE IA AND HJ JANES. 1979.  TOXICOLOGICAL STUDIES OF SHALE OILS. SOME OF THEIR COMPONENTS AND COMMERCIAL PRODUCTS  ENVIRON HEALTH
                 PERSPECT.  30: 141-146.

                 "?*!!*;  1987' HEALTH EFFECTS ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

 DIMETHYLPHENOL.  3.4-                                      000095-65-8
         005437  VELDRE IA AND HJ JANES. 1979.  TOXICOLOGICAL STUDIES OF SHALE OILS. SOME OF THEIR COMPONENTS AND COMMERCIAL PRODUCTS  ENVIRON HEALTH
                 PERSPECT.  30: 141-146.
                 ™™.n.       EFFECTS ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC

                 US  EPA. 1986. RfD/RfC WORK GROUP.

DIMETHYLPHTHALATE                                          000131-11-3
         010267   US  EPA. 1994. RfD/RfC WORK GROUP.

         010894   US  EPA. 1990. RfD/RfC WORK GROUP.

DIMETHYLTEREPHTHALATE                                     000120-61-6
         005930   NCI (NATIONAL CANCER INSTITUTE). 1979.  BIOASSAY OF  DIMETHYL TEREPHTHALATE FOR POSSIBLE CARCINOGENIC ITY.  DHEW/PUB/NIH 79-1376
                 NCI-CG-TR121.

                 US  EPA. 1984. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR DIMETHYL AND METHYL  TEREPHTHALATE  PREPARED BY THE  OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE .  WASHINGTON .  DC .

DIMETHYLUREA.  N.N-                                         000598-94-7
         005931   US EPA. 1984.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR N.N-DIMETHYLUREA  PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON.  DC.

DINITRO-0-CRESOL. 4.6-                                    000534-52-1
        010470  US EPA. 1993.  RfD/RfC WORK GROUP.

                US EPA. 1986.  HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR DINITROCRESOLS   PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.



                                                                                                                                                Rl-43

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                                          REFERENCES  FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN  CARCINOGEN1CITY)                                              May 1995


DINITRO-P-CRESOL. 2.6-                                   000609-93-8
        005934  US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.6-DINITRO-P-CRESOL  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.

DINITROBENZENE.  1.2-                                      000528-29-0
        010201  CODY TE.  S WITHERUP. L HASTINGS.  K STEMMER AND RT CHRISTIAN.  1981.  1.3-DINITROBENZENE:  TOXIC EFFECT IN VIVO AND IN VITRO J TOXICOL
                ENVIRON HEALTH.  7(5): 829-847.

                US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROBENZENES (0-. M-.  P-).  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE.  WASHINGTON. DC.

DINITROBENZENE.  1.3-                                      000099-65-0
        010471  CODY TE.  S WITHERUP. L HASTINGS.  K STEMMER AND RT CHRISTIAN.  1981   1.3-DINITROBENZENE  TOXIC EFFECT IN VIVO AND IN VITRO. J TOXICOL
                ENVIRON HEALTH.  7(5): 829-847.

                US EPA. RfD/RfC  WORK GROUP.

DINITROBENZENE.  1.4-                                      000100-25-4
        010202  CODY TE.  S WITHERUP. L HASTINGS.  K STEMMER AND RT CHRISTIAN.  1981.  1.3-DINITROBENZENE:  TOXIC EFFECT IN VIVO AND IN VITRO. J TOXICOL
                ENVIRON HEALTH.  7(5): 829-847.

                US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROBENZENES (0-. M-.  P-).  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE.  WASHINGTON. DC.

DINITROPHENOL.  2.3-                                       000066-56-8
        005936  US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.
                                                                                                                                                Rl-44

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                                          REFERENCES  FOR HEAST  TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              Hay 1995


DINITROPHENOL.  2.4-                                        000051-28-5
        010438  HORNER WD. 1942.  DINITROPHENOL AND ITS RELATION TO FORMATION OF CATARACTS.  ARCH OPHTHALMOL. 27: 1097-1121.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR DINITROPHENOLS (SELECTED)  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
                DC.

                US EPA. 1991. RfD/RfC WORK GROUP.

        010895  US EPA. 1991. RfD/RfC WORK GROUP.

DINITROPHENOL.  2.5-                                        000329-71-5
        005937  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

DINITROPHENOL.  2.6-                                        000573-56-8
        005938  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR DINITROPHENOLS (SELECTED)  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

DINITROPHENOL.  3.5-                                        000586-11-8
        005939  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR DINITROPHENOLS (SELECTED)  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

DINITROTOLUENE.  2.3-                                       000602-01-7
        005940  US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR DINITROTOLUENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

DINITROTOLUENE.  2.4                                     000121-14-2
        005941  ELLIS HV.  CB HONG.  CC LEE. ET AL. 1985.  SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF 2.4-DINITROTOLUENE. PART I. BEAGLE DOGS  J AM COLLEGE
                TOXICOL.  4(4):  233-242.

                US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR DINITROTOLUENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA.  1991. RfD/RfC WORK GROUP.
                                                                                                                                                Rl-45

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                                          REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                              (OTHER THAN CARCINOGEN1CITY)                                              May 1995


DINITROTOLUENE.  2.4-                                      000121-14-2
        010896  US EPA. 1990.  RfC WORK GROUP.

DINITROTOLUENE.  2.5-                                      000619-15-8
        005942  US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON. DC.

DINITROTOLUENE.  2.6-                                      000606-20-2
        005943  LEE C-C ET AL.  1976.  MAMMALIAN TOXICITY OF MUNITIONS COMPOUNDS.  PHASE II:  EFFECTS OF MULTIPLE DOSES.  PART III: 2.6-DITINROTOLUENE.  US
                ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND. FORT DETRICK. MD.

                US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON. DC.

                US EPA. 1991.  RfD/RfC WORK GROUP.

DINITROTOLUENE.  3.4-                                      000610-39-9
        005944  US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON. DC.

DINOSEB                                                     000088-85-7
        005945  DOW CHEMICAL COMPANY. 1981. CONFIDENTIAL BUSINESS INFORMATION.  UNPUBLISHED STUDY  MRID NO 00152675.  AVAILABLE FROM EPA. WRITE TO FOI.
                EPA. WASHINGTON.  DC 20460.

                US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINOSEB. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON. DC

                US EPA. 1986.  RfD/RfC WORK GROUP.

DIPHENYLAMINE.  N.N-                                       000122-39-4
        005946  THOMAS JO. WE  RIBELIN. JR WOODWARD AND F DEEDS. 1967. THE CHRONIC TOXICITY OF DIPHENYLAMINE FOR DOGS  TOXICOL APPL PHARMACOL  11.
                184-194.

                US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIPHENYLAMINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1986.  RfD/RfC WORK GROUP.
                                                                                                                                                Rl-46

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                                           REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGEN1CITY)                                               May 1995


DIRECT  LIGHTFAST  BLUE                                     004399-55-7
         005947   US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT LIGHTFAST  BLUE. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                 ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                 WASHINGTON. DC.

DISULFOTON                                                  000298-04-4
         010412   MOBAY  CHEMICAL COMPANY. 1985.  MRID NO. AVAILABLE FROM EPA. WRITE TO FOI.  EPA.  WASHINGTON. DC 20460

                 US EPA.  1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DISULFOTON.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE,  WASHINGTON DC.

                 US EPA.  1986. RfD/RfC WORK GROUP.

ENDOSULFAN                                                  000115-29-7
         010926   HOECHST  CELANESE CORP. 1989.  ENDOSULFAN: 2-YEAR FEEDING/ONCOGENICITY STUDY IN  RATS  MRID NO. 40256502, 42099502.  HED  DOC  NO. 007937.
                 AVAILABLE FROM EPA. WRITE TO FOI.  EPA, WASHINGTON. DC 20460.

                 US EPA.  1993. RfD/RfC WORK GROUP.

         010938   HOECHST  CELANESE CORP. 1989.  ENDOSULFAN: 1-YEAR FEEDING STUDY IN DOGS. MRID. NO 41099501  HED NO. 007937. AVAILABLE FROM  EPA  WRITE TO
                 FOI. EPA. WASHINGTON, DC 20460.

                 US EPA.  1993. RfD/RfC WORK GROUP.

ENDOTHALL                                                   000145-73-3
         005948   PENNWALT AGCHEM. ND MRID NO 00101735. AVAILABLE FROM US EPA. WRITE TO FOI, EPA. WASHINGTON. DC 20460.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ENDOTHALL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

ENDRIN                                                       000072-20-8
         005445   VELSICOL CHEMICAL CORPORATION.  1969. MRID NO. 00030198. AVAILABLE  FROM EPA.  WRITE FOI. EPA, WASHINGTON. DC 20460.

                 US EPA.  1991. DRINKING WATER CRITERIA DOCUMENT FOR ENDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR ENDRIN. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL  CRITERIA
                 AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY  AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA.  1988. RfD/RfC WORK GROUP.


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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER  THAN CARCINOGENICITY)                                              May 1995


EPICHLOROHYDRIN                                            000106-89-8
        010440  LASKIN S. AR SELLAKUMAR.  M KUSCHNER. ET AL. 1980.  INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN  NON-INBRED SPRAGUE-DAWLEY RATS.  J NATL
                CANCER INST. 65(4): 751-757.

                US EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE  PARK. NC  EPA 600/8-83-032F.  NTIS PB85-132363.

                US EPA. 1991. RfD/RfC WORK GROUP.

        010492  QUAST JF. JW HENCK. BJ POSTMA.  DJ SCHUETZ AND MJ MCKENNA.1979. EPICHLOROHYDRIN - SUBCHRONIC STUDIES.  I. A 90-DAY INHALATION STUDY IN
                LABORATORY RODENTS. (FISCHER 344 RATS. SPRAGUE-DAWLEY RATS AND B6C3F1 MICE). DOW CHEMICAL USA.  MIDLAND. MI.

                US EPA. 1991. RfD/RfC WORK GROUP.

EPTC                                                         000759-94-4
        005959  PPG INDUSTRIES. INC. 1986. CONFIDENTIAL BUSINESS INFORMATION: UNPUBLISHED STUDY  ACCESSION NO.  263695. 262696. MRID NO. 00161597.
                AVAILABLE FROM EPA. WRITE FOI.  EPA. WASHINGTON. DC 20460.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPTC.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ETHOPROP                                                     013194-48-4
        005951  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHOPROP. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

ETHOXYETHANOL ACETATE.  2-                                000111-15-9
        010507  UNION CARBIDE. 1984. A TERATOGENIC  EVALUATION OF CELLOSOLVE ACETATE  IN FISHER 344 RATS AND NEW ZEALAND WHITE RABBITS FOLLOWING INHALATION
                EXPOSURE. BUSHY RUN RESEARCH CENTER. EXPORT. PA.  OCTOBER 1984. FYI-AX-1184-0360

                US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

ETHOXYETHANOL ACRYLATE.  2-                               000106-74-1
        005953  US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.
                                                                                                                                                 Rl-48

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER  THAN  CARCINOGENICITY)                                              May 1995



ETHOXYETHANOL DODECANOATE. 2-                            000106-13-8
         005956   US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL  ESTERS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

ETHOXYETHANOL PHOSPHATE.  2-                              068554-00-7
         005955   US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL  ESTERS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

ETHOXYETHANOL. 2-                                          000110-80-5
         005470   MELNICK  RL. 1984.  TOXICITIES  OF ETHYLENE GLYCOL AND ETHYLENE GLYCOL MONOETHYL ETHER IN FISCHER 344/N RATS AND B6C3F1 MICE. ENVIRON HEALTH
                 PERSPECT. 57: 147-155.

                 US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXY-ETHANOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

         005468   STENGER  EG. A LISLOTT.  D MUELLER ET AL. 1971. TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYL ETHER.  ARZNEIM-FORSCH. 21(6): 880-885.

                 US  EPA.  1984. HEALTH EFFECTS  ASSESSMENT FOR GLYCOL ETHERS.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC. EPA 540/1-86-052.

         010441   BARBEE SJ. JB TERRILL.  DJ DESOUSA AND CC CONAWAY. 1984.  SUBCHRONIC INHALATION TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYL ETHER IN THE RAT
                 AND RABBIT. ENVIRON  HEALTH PERSPECT. 57: 157-163.

                 US  EPA.  1984. HEALTH EFFECTS  ASSESSMENT FOR GLYCOL ETHERS.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC. EPA 540/1-86-052.

                 US  EPA.  1990. RfD/RfC WORK GROUP.

ETHOXYETHYL METHACRYLATE.  2-                             002370-63-0
         005954   US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL  ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.
                                                                                                                                                 Rl-49

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995



ETHYL ACETATE                                               000141-78-6
        005957  US EPA. 1986. RAT ORAL SUBCHRONIC  STUDY WITH ETHYL ACETATE.  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC

                US EPA  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL ACETATE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA. 1986. RfD/RfC WORK GROUP.

ETHYL BENZENE                                               000100-41-4
        010867  WOLF MA. VK ROWE. DO MCCOLLISTER.  RL HOLLINGSWORTH AND F OYEN.  1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND BENZENES. AMA
                ARCH IND HEALTH. 14: 387-398.  CITED IN US EPA. 1985.

                US EPA  1984  HEALTH EFFECTS ASSESSMENT FOR ETHYLBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND  REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA  1986  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYLBENZENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA. 1985. RfD/RfC WORK GROUP.

        010866  ANDREW  FD. RL BUSHCOHBOM. WC CANNON. ET AL.  1981. TERATOLOGIC ASSESSMENT OF ETHYLBENZENE AND 2-ETHOXYETHANOL. BATTELLE PACIFIC NORTHWEST
                LABORATORY. RICHLAND. WA. NTIS PB83-208074. P 108.

                HARDIN  BD. GP BOND. MR SIKOV.  ET AL.  1981. TESTING OF SELECTED WORKPLACE CHEMICALS FOR TERATOGENIC POTENTIAL. SCANDJ WORK ENVIRON HEALTH.
                7: 66-75.

                US EPA. 1990. RfD/RfC WORK GROUP.

ETHYL CHLORIDE                                              000075-00-3
        010371  SCORTICHINI BH.  KA JOHNSON. JJ MOMANY-PFRUENDER  ET AL  1986. ETHYL CHLORIDE:  INHALATION TERATOLOGY STUDY IN CF-1 MICE. DOW CHEMICAL CO.
                EPA  86-870002248.

                US EPA. 1990. RfD/RfC WORK GROUP.

ETHYL ETHER                                                 000060-29-7
        010396  AMERICAN  BIOGENICS CORP. 1986. 90-DAY GAVAGE STUDY  IN RATS  USING ETHYL ETHER   STATUS REPORT FOR ABC STUDY NO. 410-23433/18/86.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT  FOR  ETHYL ETHER. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH. OFFICE OF SOLID
                WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                US EPA. 1989. RfD/RfC WORK GROUP.

                                                                                                                                                  Rl-50

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER  THAN CARCINOGEN1CITY)                                              May 1995


ETHYL  METHACRYLATE                                        000097-63-2
         005961   BORZELLECA JF. PS LARSON.  GR HENNIGAR. ET AL. 1964.  STUDIES ON THE CHRONIC ORAL TOXICITY OF MONOMERIC ETHYL ACRYLATE AND METHYL
                 METHACRYLATE. TOXICOL APPL PHARMACOL. 6: 29-36.

                 US  EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL METHACRYLATE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

ETHYL-0-XYLENE.  4-                                        000934-80-5
         010472   US  EPA. 1984. HEALTH AND ENVIRONMENTAL PROFILE FOR METHYLETHYL BENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC.

ETHYLANILINE.  N-                                           000103-69-5
         005958   US  EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N-ETHYLANILINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON. DC.

ETHYLENE CYANOHYDRIN                                      000109-78-4
         005780   SAUERHOFF MW. WH BRAUN.  JC RAMSEY ET AL.  1976.  TOXICOLOGICAL EVALUATION AND PHARMACOKINETIC PROFILE OF B-HYDROXYPROPIONITRILE  IN RATS  J
                 TOXICOL. ENVIRON.  HEALTH.  2(1): 31-44.

                 US  EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON. DC.

ETHYLENE DIAMINE                                           000107-15-3
         005796   YANG RS. RH GARMAN.  RR MARONPOT. ET AL.  1983. ACUTE AND  SUBCHRONIC TOXICITY OF ETHYLENEDIAMINE  IN LABORATORY ANIMALS  APPL TOXICOL  3(6)-
                 512-520.

                 US  EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR ETHYLENEDIAMINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON.  DC.

         010898  US  EPA. 1990.  RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-51

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                                         REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                             (OTHER THAN CARCINOGENIC ITY)                                               "*y 1995
                      LR. RH GARMAN. MD WOOOSIDE  ET AL. 1986.       craiciTY AND ONCOGENICITY STUDIES OF ETHYLENE GLYCOL IN RATS AND MICE.  FUND APPL

                TOXICOL. 7: 547-565.

                US EPA.  1987. RfD/RfC WORK GROUP.

        005452  MARONPOT RR. JP ZELENAK. EV WEAVER AND  NJ SMITH  1983.  TERATCGENICITY  STUDY OF ETHYLENE GLYCOL IN RATS.  DRUG CHEM TOXICOL. 6(6): 579-594.

                US EPA  1987  HEALTH EFFECTS ASSESSMENT FOR ETHYLENE GLYCOL  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                SlTERiA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
                                     . RR MAROMPOT.  ET AL.  ^EDL MONOBUTYL  ETHER. ACUTE. 9-DAY AND 90-DAY VAPOR INHALATION STUDIES IN
                FISCHER 344 RATS.  TOXICOL APPL PHARMACOL. 68: 405-414.

                US EPA. 1991.  RfD/RfC WORK GROUP.

CTTJVI cur  TUTDIIPPA                                          000096-45-7
        010397  GRAHAM SL. KJ DAVIS.  WH  HANSEN AND CH GRAHAM.  1975. EFFECTS OF PROLONGED ETHYLENE THIOUREA  INGESTION ON THE THYROID OF THE RAT. FOOD
                COSMET TOXICOL.  13:  493-499.

                US EPA. 1991.  RfD/RfC WORK GROUP.

        010899  US EPA. 1992.  RfD/RfC WORK GROUP.

ETTLJVI rni iirur   M                                            000620-14-4
ETHYLTOLUtNt.  M-                      ENVIRONMENTAL EFFECTS PROFILE  FOR METHYL ETHYL BENZENE  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                A^SEsSMEN?  EN!SENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

CTUVI rni IICWF   n                                            000611-14-3
ETHYLTOLUtNt.  U-                      ENVIRONMENTAL EFFECTS PROFILE  FOR METHYL ETHYL BENZENE  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                JLS^BWwSfZ ™A AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.

                WASHINGTON. DC.

CTUVI TOI i IPMP   P                                            000622-96-8
         005964   US EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR METHYL ETHYL BENZENE  PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                                                  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON.  DC.
                                                                                                                                                 Rl-52

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                                           REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                              May 1995


 FLUORANTHENE                                               000206-44-0
         010168  US EPA.  1988.  13-WEEK MOUSE ORAL  SUBCHRONIC TOXICITY STUDY.  PREPARED  BY TOXICITY RESEARCH LABORATORIES.  LTD MUSKEGON  MI FOR THE OFFICE
                 OF SOLID WASTE, WASHINGTON. DC.

                 US EPA.  1989.  RfD/RfC WORK GROUP.

         010967  US EPA.  1994. RfD/RfC WORK GROUP.

 FLUORENE                                                    000086-73-7
         010169  US EPA.  1989. MOUSE ORAL SUBCHRONIC STUDY. PREPARED BY TOXICITY  RESEARCH LABORATORIES.  LTD.  MUSKEGON  MI  FOR THE OFFICE OF SOLID WASTE
                 WASHINGTON. DC.

                 US EPA.  1991. DRINKING WATER CRITERIA DOCUMENT FOR FLUORENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF DRINKING WATER. WASHINGTON.  DC.

                 US EPA.  1989. RfD/RfC WORK GROUP.

FLUORINE / (SOLUBLE FLUORIDE)                            007782-41-4
         005965   HODGE HC. 1950. THE CONCENTRATION OF FLUORIDES IN DRINKING WATER TO GIVE THE POINT OF MINIMUM CARIES WITH MAXIMUM SAFETY  J AM  DENT
                 ASSOC. 40: 436.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  FLUORIDE. PREPARED BY THE OFFICE  OF HEALTH AND  ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US  EPA. 1986. RfD/RfC WORK GROUP.

FLURIDONE                                                   059756-60-4
        005966   ELANCO PRODUCTS COMPANY.  DIVISION OF ELI  LILLY AND COMPANY.  1980. CONFIDENTIAL BUSINESS INFORMATION  UNPUBLISHED STUDY  ACCESSION NOS
                 070933. 070939. MRID NO.  00103251. 00103305. AVAILABLE FROM EPA. WRITE TO FOI. EPA,  WASHINGTON. DC 20460.

                 US EPA-. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FLURIDONE.  PREPARED BY THE OFFICE  OF HEALTH AND  ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE AND EMERGENCY RESPONSE.
                WASHINGTON,  DC.

                US EPA. 1988.  RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-53

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                             (OTHER THAN CARCINOGEN 1C ITY)                                             May 1995
 FOLPET                                                     000133-07-3
         005967  ™™       "                              UN™LISHEO STUOY  ACCESSIOI<
                 US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FOLPET.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID
                 US EPA. 1987.  RFD/RFC WORK GROUP.


 FORMALDEHYDE                                               000050-00-0
         010398   TIL HP. RA WOUTERSEN. VJ FERON ET AL  1989.  TWO-YEAR DRINKING WATER STUDY OF FORMALDEHYDE IN RATS.  FOOD CHEM TOXICOL.  27.  77-87.

                 US EPA. 1989.  DRAFT DRINKING WATER HEALTH ADVISORY FOR FORMALDEHYDE. OFFICE OF DRINKING WATER.  WASHINGTON. DC.

                 US EPA. 1990.  RfD/RfC WORK GROUP.


 FORMALDEHYDE CYANOHYDRIN                                 000107-16-4

         005782   US EPA. 1988.  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR CYANOHYDRINS.  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAI
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID
FORMIC ACID                                               000064-18-6
        010268  MALORNY G.  1969. ACUTE AND CHRONIC TOXICITY OF FORMIC ACID AND FORMATE.  Z ERNACHRUNGSWISS.  9:  332-339.

                US EPA.  1990. RfD/RfC WORK GROUP.

FURAN                                                      000110-00-9

        005462               SSS ™                     'ICI" Kmi " fam  (C5K02) '" ra MICE
                US EPA.  1987. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR FURAN.  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTS ASSFSSMFNT
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AN[ ) EMCY SS  JisS  DC.

                US EPA.  1986. RfD/RfC WORK GROUP.


FURFURAL                                                   000098-01-1
        005466   SRI  (SOUTHERN RESEARCH INSTITUTE).  1981. 90 DAY RAT REPORT. UNPUBLISHED STUDY PERFORMED  FOR NTP

                US EPA.  1987. RfD/RfC WORK GROUP.
                                                                                                                                            Rl-54

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC  AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              Hay 1995


 6LYCIDALDEHYDE                                             000765-34-4
         005968  MINE  CH. RJ GUZMAN. MK DUNLAP. R LIMA AND GS LOQUVAM.  1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH  ENVIRON HEALTH.  2:  23-30.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR GLYCIDALDEHYDE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1987. RfD/RfC WORK GROUP.

 HEPTACHLOR                                                  000076-44-8
         005506  VELSICOL CHEMICAL CORP.  1955. MRID NO 00062599. AVAILABLE FROM EPA.  WRITE TO FOI, EPA. WASHINGTON,  DC 20460.

                 US EPA.  1987. RfD/RfC WORK GROUP.

 HEPTACHLOR EPOXIDE                                        001024-57-3
         010399   DOW CHEMICAL CO.  1958. MRID NO 00061912.  AVAILABLE  FROM EPA. WRITE TO  FOI.  EPA. WASHINGTON.  DC 20460

                 US EPA.  1986. RfD/RfC WORK GROUP.

HEPTANE.  N-                                                 000142-82-5
         005969   US EPA. 1989. HEALTH  AND  ENVIRONMENTAL EFFECTS  DOCUMENT FOR N HEPTANE.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.  '

HEXABROMOBENZENE                                           000087-82-1
         005970  MENDOZA CE.  HM VIJAY.  JB  SHIELDS  AND GW LAVER   1977. EFFECTS OF  HEXABROMOBENZENE ON THE MALE RAT. TOXICOL APPL PHARMACOL  41. 127-130.

                US EPA. 1984.  HEALTH  AND  ENVIRONMENTAL EFFECTS  PROFILE FOR BROMOBENZENES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF SOLID WASTE.  WASHINGTON. DC.

                US EPA. 1985.  RfD/RfC WORK GROUP.
                                                                                                                                               Rl-55

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995

 HEXACHLOROBENZENE                                        000118-74- 1
         010868  ARNOLD     *-*™»       ET *• ™- LONG-TERM TOXICITY OF HEXACHLOROBENZENE IN THE RAT AND THE EFFECT OF DIETARY VITAMIN
                 US EPA.  1991. DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROBENZENE. PREPARED BY THE ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE
                 OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI.  OH FOR THE OFFICE OF WATER. WASHINGTON DC            ASSESSMENT OFFICE.

                 US EPA.  1988. RfD/RfC WORK GROUP.

         010900   US EPA.  1990. RfD/RfC WORK GROUP.

 HEXACHLOROBUTADIENE                                      000087-68-3
         010927   NTP (NATIONAL TOXICOLOGY PROGRAM).  1991. NTP REPORT ON THE  TOXICITY STUDIES  OF  HEXACHLORO-1.3-BUTADIENE IN B6C3F1 MICE  (FEED STUDIES).
                                                                                                              (HCBD) IN B6C3F1  MICE BY DIETARY

                                                                                              STUDY WI™  HEXACHLOROBUTADIENE  IN RATS. AM IND HYG
                US EPA. 1993.  RfD/RfC WORK GROUP.
HEXACHLOROCYCLOHEXANE.  DELTA-                           000319-86-8
        010495  US EPA.  1987.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMFNTAI
                              VIRONMENTAL CRITERIA AN° ASSESSMENT °FFICE' CINCINNATI' OH ™ THE OFFICE OF                                   ^
HEXACHLOROCYCLOHEXANE.  EPSILON-                         006108-10-7
        010496  US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR HEXACHLOROCYCLOHEXANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMFNTAI
                          ' ECNVIR°NMENTAL CRITERIA MD ASSESSMENT OFFICE' CINCINNATI. OH ™ THE OFFICE OF                                   ^
HEXACHLOROCYCLOHEXANE.  GAMMA-                           000058-89-9
        005537  ZOECON CORPORATION.  1983. MRID NO 00128356. AVAILABLE FROM EPA  WRITE TO FOI .  EPA. WASHINGTON.  DC 20460.
                US EPA.  1986. RfD/RfC WORK GROUP.

        010903  US EPA.  1992. RfD/RfC WORK GROUP.
                                                                                                                                             Rl-56

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                                           REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER  THAN  CARCINOGEN1CITY)                                               Hay 1995



 HEXACHLOROCYCLOPENTADIENE                                000077-47-4
         005299  AflDO. KM.  CA MONTGOMERY. MM KLUWE ET AL. 1984  TOXICITY  OF HEXACHLOROCYCLOPENTADIENE: SUBCHRONIC (13-WEEK) ADMINISTRATION BY GAVAGE TO
                 F344 RATS AND B6C3F1 MICE. J APPL TOXICOL.  4: 75-81.


                 US EPA.  1991.  DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROCYCLOPENTANE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
                 OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  CINCINNATI.  OH FOR THE OFFICE OF WATER. WASHINGTON.  DC.

                 US EPA.  1985.  RfD/RfC WORK GROUP.


         010445  ABDO. KM.  CA MONTGOMERY. J ROYCROFT.  HA RAGAN.  RA RENNE. WE GIDDINS. 1986  SUBCHRONIC (13-WEEK) OINHALATION TOXCICITY OF
                 HEXACHLOROCYCLOPENTADIENE (HCCPD) IN F344 RATS AND B6C3F1  MICE. ABSTRACT SUBMITTED TO THE SOCIETY OF TOXICOLOGY  FROM THE 1986 MEETING.

                 BATTELLE NORTHWEST LABORATORIES.  1984.  INHALATION CARCINOGENESIS BIOASSAY STUDY. SUBCHRONIC STUDY REPORT ON HEXACHLOROCYCLOPENTADIENE IN
                 RATS. SUBMITTED  TO THE NATIONAL TOXICOLOGY  PROGRAM.


                 US EPA.  1988.  HEALTH AND DNVIRONMENTAL  EFFECTS DOCUMENT  FOR HEXACHLOROCYCLOPENTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON.  DC.


                 US EPA.  1991.  DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROCYCLOPENTADIENE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
                 OFFICE.  CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.


HEXACHLOROETHANE                                            000067-72-1
         005518   GOR2INSKI. SJ. RJ NOLAN.  SB MCCOLLISTER.  ET AL. 1985. SUBCHRONIC ORAL TOXICITY.  TISSUE DISTRIBUTION AND  CLEARANCE OF HEXACHLOROETHANE IN
                 THE  RAT. DRUG  CHEM TOXICOL.  8(3):  155-169.


                 US EPA.  1989.  HEALTH AND ENVIRONMENTAL  EFFECTS  DOCUMENT FOR HEXACHLOROETHANE. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI. OH.  FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.
                 WASHINGTON.  DC.

                 US EPA.  1987. RfD/RfC WORK GROUP.

         010904   US EPA.  1992. RfD/RfC WORK GROUP.
                                                                                                                                                  Rl-57

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995


HEXACHLOROPHENE                                            000070-30-4
        005972  NATIONWIDE CHEMICAL CORPORATION. 1974. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 00055365. AVAILABLE FROM  EPA. WRITE
                TO FOI. EPA. WASHINGTON.  DC  20460.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROPHENE  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE. WASHINGTON.  DC.

                US EPA. 1988. RfD/RfC WORK GROUP.

HEXAMETHYLENE  DIAMINE                                     000124-09-4
        005973  US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXAMETHYLENEDIAMINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

HEXANE. N-                                                  000110-54-3
        005974  KRASAVAGE WJ. JL O'DONOGHUE. GD DIVINCENZO AND TERHAAR. 1980. RELATIVE NEUROTOXICITY OF  METHYL-N-BUTYL KETONE. N-HEXANE  AND THEIR
                METABOLITES. TOXICOL APPL PHARMACOL. 52(3): 433-441.

                US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N-HEXANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

        010273  SANAGI S. Y SEKI. K SUGIMOTO AND M HIRATA.  1980.  PERIPHERAL NERVOUS SYSTEM FUNCTIONS OF  WORKERS EXPOSED TO N-HEXANE AT A LOW LEVEL.  INT
                ARCH OCCUP ENVIRON HEALTH. 47: 69-79.

HEXANONE.  2-                                                000591-78-6
        005976  US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N-HEXANONE.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.
                                                                                                                                                 Rl-58

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                                           REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGEN1CITY)                                              May 1995


HYDROGEN SULFIDE                                           007783-06-4
         010269  WATTERAU H. W OECKERT AND UG KNAPE.  1964. TESTS FOR THE APPLICATION OF  DRIED GREEN FODDER WITH HIGH H2S  CONTENT  (EXPERIMENTS WITH POULTRY
                 AND  FATTENED PIGS). LETTIN FEEDS  TESTING CENTER AND FEEDING HALL.  FEEDS SCIENCE. FETTERUNG  5: 383-393.

                 US EPA.  1985. RfD/RfC WORK GROUP.

         010354  CUT.  1983. 90 DAY VAPOR INHALATION  TOXICITY STUDY OF HYDROGEN SULFIDE  IN B6C3F1 MICE. EPA OTS PUBLIC  FILES  FICHE N00000255-0  DOCUMENT
                 NO FYI-OTS-0883-0255.

                 US EPA.  1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HYDROGEN SULFIDE. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.
                 WAoHINGTON. DC.

                 US EPA.  1990. RfD/RfC WORK GROUP.

HYDROQUINONE                                               000123-31-9
         005526   CARLSON. AJ AND NR BREWER.  1953. TOXICITY STUDIES ON HYDROQUINONE   PROC SOC EXP BIOL MED.  84:  684-688

                 US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  HYDROQUINONE  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

         010905   US EPA.  1990. RfD/RfC WORK GROUP.

IRON                                                         007439-89-6
         005527   US EPA.  1984.  HEALTH EFFECTS ASSESSMENT FOR IRON.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. OFFICE OF EMERGENCY AND
                 KtMtDIAL RESPONSE.  WASHINGTON, DC.

ISOBUTYL ALCOHOL                                           000078-83-1
         005977   US EPA.  1986.  RAT ORAL  SUBCHRONIC TOXICITY  WITH ISOBUTYL ALCOHOL. OFFICE OF SOLID WASTE.  WASHINGTON. DC.

                US EPA. 1986.  HEALTH AND  ENVIRONMENTAL EFFECTS  PROFILE  FOR ISOBUTANOL.  PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF  SOLID WASTE.  WASHINGTON.  DC.

                US EPA. 1986.  RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-59

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                                          REFERENCES FOR HEAST  TABLE  1:   SUBCHRONIC  AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995


ISOPHORONE                                                   000078-59-1
        005910  NOR-AM AGRICULTURAL  PRODUCTS. INC. 1972.  MRID  NO  00123976. AVAILABLE FROM EPA.  WRITE TO  FOI. EPA. WASHINGTON.  DC 20460.

                NTP (NATIONAL TOXICOLOGY PROGRAM). 1986.  TOXICOLOGY  AND CARCINOGENESIS STUDIES OF  ISOPHORONE (CAS NO 78-59-1)  IN F344/N  RATS AND  B6C3F1
                MICE (GAVAGE STUDIES).  NTP TECH REPORT SER NO  291. NIH PUBL NO 86-2547.

                US EPA. 1993. REVISED AND UPDATED DRINKING WATER  QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR  ISOPHORONE. PREPARED BY THE OFFICE OF  HEALTH
                AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF WATER.  WASHINGTON. DC.

                US EPA. 1989. RfD/RfC WORK GROUP.

        010906  US EPA. 1990. RfD/RfC WORK GROUP.

ISOPROPALIN                                                 033820-53-0
        005978  ELI LILY CO. 1985. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOPROPALIN  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE. WASHINGTON. DC.

                US EPA. 1986. RfD/RfC WORK GROUP.

LACTONITRILE                                                000078-97-7
        005783  US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES.  PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.

LEAD                                                         007439-92-1
        010447  REFER TO IRIS.

LEAD ALKYLS
        010448  REFER TO IRIS.

LINURON                                                      000330-55-2
        005990  DU PONT DE NEMOURS AND  COMPANY. INC. 1962. CONFIDENTIAL BUSINESS INFORMATION,  UNPUBLISHED STUDY. MRID NO 00018374. AVAILABLE FROM EPA.
                WRITE TO FOI. EPA. WASHINGTON. DC 20460.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR LINURON. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE  AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                US EPA. 1986. RfD/RfC WORK GROUP.


                                                                                                                                                 Rl-60

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                                           REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               Hay 1995


MALATHION                                                    000121-75-5
         005991   MOELLER HC AND JA RIDER. 1962. PLASMA AND RED BLOOD CELL-CHOLINESTERASE ACTIVITY AS INDICATIONS OF THE THRESHOLD OF INCIPIENT TOXICITY OF
                 ETHYL-P-NITROPHENOL THIONEBENZENEPHOSPHORATE  (EPN)  AND MALATHION IN HUMAN BEINGS.  TOXICOL APPL PHARMACOL. 4: 123-130.

                 US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALATHION. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

                 US EPA.  1987. RfD/RfC WORK GROUP.

NALEIC  ANHYDRIDE                                           000108-31-6
         005992   JESSUP DC.  D ALDRIDGE. JL SCHARDEIN AND M BLAIR.  1982. THREE-GENERATION REPRODUCTION STUDY IN RATS (MODIFIED TO A2-GENERATION STUDY).
                 MALEIC ANHYDRIDE IR-79-358. INTERNATIONAL RESEARCH  AND DEVELOPMENT CORP. FOR MONSANTO CO..  ST. LOUIS.MO  UNPUBLISHED 8D SUBMISSION.
                 MICROFICHE NO OTS 0206655.  DOCUMENT ID 878214777

                 PREACHE M.  1983. CHRONIC DIETARY ADMINISTRATION OF  MALEIC ANHYDRIDE. VOL. 1  NARRATIVE.  FYI-OTS SUBMISSION 1283-0277. PREPARED BY ITT
                 RESEARCH INSTITUTE FOR CHEMICAL INDUSTRY INSTITUTE  OF TECHNOLOGY. RESEARCH TRIANGLE PARK.  NC.

                 US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALEIC ANHYDRIDE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1988. RfD/RfC WORK GROUP.

MALEIC  HYDRAZIDE                                           000123-33-1
         005993   UNIROYAL CHEMICAL CO.  1981. ACCESSION NO.  250523.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MALEIC ANHYDRIDE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1986. RfD/RfC WORK GROUP.

MALONONITRILE                                               000109-77-3
         005994   PANOV  I.  M ZLATEVA AND G ANTOV.  1972.  TOXICOLOGICAL  CHARACTERISTICS OF DICYANOMETHANE. CHRONIC EFFECTS IN WHITE RATS  KHIG
                 ZDRAVEOPAZVANE. 15(6): 553-562.

                 US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALONONITRILE, PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
                                                                                                                                                  Rl-61

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                                           REFERENCES  FOR HEAST  TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                              May  1995


HANCOZEB                                                     008018-01-7
        005995  US EPA  1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR MANCOZEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.

MANEB                                                         012427-38-2
        005996  MANEB DATA TASK FORCE. 1986. MRID NO 00161552.  (CITED  IN US EPA 1987.) AVAILABLE FROM EPA. WRITE TO FOI.  EPA.  WASHINGTON. DC 20460.

                ROHM AND HAAS CO.  1977. MRID NO 00129980.  (CITED  IN  US EPA 1987.) AVAILABLE FROM EPA  WRITE TO FOI.  EPA.  WASHINGTON. DC 20460.

                US EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR MANEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.

MANGANESE                                                    007439-96-5
        010850  KONDAKIS XG. N MAKRIS. M LEOTSINIDIS. M PRINOU  AND T PAPAPETROPOULOS  1989  POSSIBLE HEALTH EFFECTS OF HIGH MANGANESE  CONCENTRATION IN
                DRINKING WATER. ARCH ENVIRON HEALTH. 44: 175-178.

                US EPA  1993. DRINKING WATER CRITERIA DOCUMENT  FOR MANGANESE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

                US EPA. 1992. RfD/RfC WORK GROUP.

        010851  WHO  (WORLD HEALTH  ORGANIZATION). 1973. TRACE ELEMENTS  IN HUMAN NUTRITION: MANGANESE. REPORT OF A WHO EXPERT COMMITTEE  TECHNICAL REPORT
                SERVICE. 532. WHO. GENEVA. SWITZERLAND. PP 34-36.

                SCHROEDER HA. JJ BALASSA.  IH TIPTON. 1966. ESSENTIAL TRACE METALS  IN MAN: MANGANESE. A STUDY IN HOMEOSTASIS. J CHRON DIS   19.  545-571.

                NRC  (NATIONAL RESEARCH COUNCIL). 1989. RECOMMENDED DIETARY ALLOWANCES. 10TH ED. FOOD AND NUTRITION BOARD. NATIONAL RESEARCH COUNCIL.
                NATIONAL ACADEMY PRESS. WASHINGTON. DC. PP 230-235.

                US EPA. 1993. DRINKING WATER CRITERIA DOCUMENT  FOR MANGANESE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

                US EPA. 1992. RfD/RfC WORK GROUP.

        010959  ROELS HA. P  GHYSELEN. JP BUCHET. E CEULEMANS.  RR LAUWERYS. 1992. ASSESSMENT OF THE PERMISSIBLE EXPOSURE LEVEL TO MANGANESE  IN  WORKERS
                EXPOSED TO MANGANESE DIOXIDE DUST. BR J IND MED.  49: 25-34.

                ROELS H. R LAUWERYS. JP BUCHET  ET AL. 1987. EPIDEMIOLOGICAL  SURVEY  AMONG WORKERS  EXPOSED TO MANGANESE: EFFECTS ON LUNG, CENTRAL NERVOUS
                SYSTEM.'AND  SOME BIOLOGICAL  INDICES. AM j IND MED. ii:  307-327.

                US EPA. 1993. RfD/RfC WORK GROUP.

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                                           REFERENCES  FOR HEAST  TABLE  1:   SUBCHRONIC  AND  CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995



MEPHOSFOLAN                                                 000950-10-7
         005997   US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MEPHOSFOLAN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

MERCURIC CHLORIDE                                         007487-94-7
         005800   ANDRES.  P.  1984. IGA-AGG DISEASE IN THE  INTESTINE OF BROWN-NORWAY RATS INGESTING MERCURIC CHLORIDE  CLIN IMMUNOL IMMUNOPATHOL.  20:
                 488-494.

                 BERNAUDIN.  JF. E DRUET. P DRUET.  R MASSE.  1981. INHALATION OR INGESTION OF ORGANIC  OR  INORGANIC MERCURIALS PRODUCES AUTO-IMMUNE DISEASE
                 IN RATS. CLIN IMMUNOL IMMUNOPATHOL.  20:  129-135.

                 DRUET. P. E DRUET.  F POTDEVIN,  C SAPIN.  1978. IMMUNE TYPE GLOMERULONEPHRITIS INDUCED BY HG CL2 IN THE BROWN NORWAY RAT.  ANN IMMUNOL.
                 129C: 777-792.

                 US EPA.  1987. PEER REVIEW WORKSHOP ON MERCURY ISSUES. OCTOBER 26-27. 1987.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH.

                 US EPA.  1988. RfD/RfC WORK GROUP.

                 U.S.' EPA.   1995.  MERCURY STUDY REPORT TO  CONGRESS.  OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON. DC.  EXTERNAL REVIEW DRAFT.
                 EPA/600/P-94/002Ab.

MERCURY ELEMENTAL                                          007439-97-6
         010270   FAWER RF. V DERIBAUPIERRE.  MP GUILLEMIN  ET AL. 1983. MEASUREMENT OF HAND TREMOR INDUCED BY INDUSTRIAL EXPOSURE TO METALLIC  MERCURY.  J  IND
                 MED. 40: 204-208.

                 PIIKIVI L.  1989. CARDIOVASCULAR REFLEXES AND LONG-TERM EXPOSURE TO MERCURY  VAPOR INT ARCH OCCUP ENVIRON HEALTH. 61:  391-395.

                 PIIKIVI L AND H HANNINEN.  1989.  SUBJECTIVE SYMPTOMS AND PSYCHOLOGICAL PERFORMANCE OF CHLORINE-ALKALI WORKERS. SCANDJ WORK ENVIRON HEALTH.
                 15:  69-74.

                 PIIKIVI L AND V TOLONEN.  1989.  EEG FINDINGS IN CHLOR-ALKALI  WORKERS SUBJECTED  TO LONG-TERM EXPOSURE TO MERCURY VAPOR  BR J  IND  MED  46-
                 370-375.

                 US EPA. 1984. HEALTH EFFECTS  ASSESSMENT FOR MERCURY. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH.  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA. 1990. RfD/RfC WORK  GROUP.
                                                                                                                                                  Rl-63

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               Hay 1995



MERPHOS                                                      000150-50-5
        005998  ABOU-DONIA MB  DG GRAHAM PR TIMMONS AND BL REICHERT.  1980. LATE ACUTE. DELAYED NEUROTOXIC AND  CHOLINERGIC EFFECTS OF
                S.S.S-TRIBUTYLPHOSPHOROTRITHIOITE  (MERPHOS) IN HENS.  TOXICOL APPL PHARMACOL  53  439-457.

                US EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MERPHOS. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

                US EPA. 1987. RfD/RfC WORK GROUP.

        010907  US EPA. 1992. RfD/RfC WORK GROUP.

MERPHOS  OXIDE                                              000078-48-8
        005999  ABOU-DONIA MB  DG GRAHAM  KM ABDO AND  AA KOMEIL. 1979. DELAYED NEUROTOXIC. LATE ACUTE AND CHOLINERGIC  EFFECTS OF
                sTs-TRIBUTYLPHOSPHOROTRITHIOATE (DEF): SUBCHRONIC (90 DAYS)  ADMINISTRATION  IN HENS  TOXICOLOGY. 14:  229-243.

                US  EPA 1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MERPHOS  OXIDE   PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI.  OH FOR THE  OFFICE  OF SOLID WASTE. WASHINGTON.  DC.

                US  EPA. 1987. RfD/RfC WORK GROUP.

         010908   US  EPA.  1992. RfD/RfC WORK GROUP.

 MFTHAPRYIONTTRILE                                          000126-98-7
         005812   POZZANI.  DC.  CR KINKEAD AND JM KING. 1968. THE MAMMALIAN TOXICITY OF METHACRYLONITRILE.  AM IND HYG ASSOC J. 29(3):  202-210

                 US EPA  1987 HEALTH AND  ENVIRONMENTAL EFFECTS  DOCUMENT FOR SELECTED NITRILES.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT  ENvSMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH.  FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.

                 US EPA.  1987.  RfD/RfC WORK GROUP.

 METHANOL                                                    000067-56-1
         010271   US EPA.  1986.  RAT ORAL  SUBCHRONIC TOXICITY STUDY WITH METHANOL. OFFICE OF SOLID WASTE. WASHINGTON. DC.

                 US EPA.  1988.  RfD/RfC  WORK GROUP.
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                                          REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                              (OTHER THAN CARCINOGEN1CITY)                                              May 1995


METHOMYL                                                    016752-77-5
        005802  E.I. DU PONT OE NEMOURS AND COMPANY.  INC.  1968. MRID 0007091. 00009012  AVAILABLE FROM EPA.  WRITE TO FOI. EPA. WASHINGTON.  DC 20460.

                US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHOMYL. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH.

                US EPA. 1986. RFD/RFC WORK GROUP.

METHOXYCHLOR                                               000072-43-5
        010357  KINCAID ENTERPRISES. INC. 1989. MRID NO  0015992. AVAILABLE FROM EPA.  WRITE TO FOI. EPA. WASHINGTON.  DC 20460.

                US EPA. 1990. RfD/RfC WORK GROUP.

        010909  US EPA. 1991. RfD/RfC WORK GROUP.

METHOXYETHANOL  ACETATE.  2-                              000110-49-6
        010497  MILLER RR.  LL CALHOUN AND BL YANO. 1982.  ETHYLENE GLYCOL MONOMETHYL ETHER. 13-WEEK VAPOR INHALATION STUDY IN MALE RABBITS  REPORT
                PREPARED FOR THE CHEMICAL MANUFACTURERS  ASSOCIATION. MARCH 25. 1982.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXYETHANOL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

METHOXYETHANOL. 2-                                        000109-86-4
        010372  MILLER RR.  JA AYRES. JL YOUNG ET AL.  1983.  ETHYLENE GLYCOL MONOMETHYL ETHER  I  SUBCHRONIC VAPOR INHALATION STUDY WITH RATS AND RABBITS.
                FUND APPL TOXICOL.  3(1): 49-54.

                US EPA. 1990. RfD/RfC WORK GROUP.

METHYL ACETATE                                             000079-20-9
        010002  TOXICITY RESEARCH LABORATORY. 1986. RAT  ORAL SUBCHRONIC TOXICITY STUDY  WITH METHANOL  SPONSORED BY OFFICE OF SOLID WASTE. US EPA.
                WASHINGTON. DC.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
                                                                                                                                                 Rl-65

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                                          REFERENCES FOR  HEAST  TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGEN1CITY)                                              May 1995


METHYL ACRYLATE                                            000096-33-3
        010498  KLIMISCH HJ AND W REININGHAUS.  1984. CARCINOGENICITY OF ACRYLATES: LONG-TERM INHALATION STUDIES ON METHYL  ACRYLATE (MA) AND N-BUTYL
                ACRYLATE (BA) IN RATS.  TOXICOLOGIST. 4(1):  53.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR METHYL ACRYLATE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

METHYL ETHYL KETONE                                       000078-93-3
        010853  COX, GE. 1975. TOXICITY STUDIES IN RATS WITH  2-BUTANOL: INCLUDING GROWTH.  REPRODUCTION. AND TERATOGENIC OBSERVATIONS  FOOD AND DRUG
                RESEARCH LABORATORIES.  INC.  (91MR R 1673)

                US EPA. 1992. RfD/RfC WORK GROUP.

        010845  SCHWETZ BA. TJ MAST.  RJ WEIGEL. ET AL. 1991.  DEVELOPMENTAL TOXICITY OF INHALED METHYL ETHYL KETONE IN MICE.  FUND APPL TOXICOL. 16:
                742-748.

                MAST. TJ. JA DILL.  JJ EVANOFF. ET AL. 1989.  INHALATION DEVELOPMENTAL TOXICOLOGY STUDIES: TERATOLOGY STUDY  OF METHYLETHYL KETONE IN  MICE.
                FINAL REPORT. PREPARED BY PACIFIC NORTHWEST LABORATORY, BATELLE MEMORIAL INSTITUTE. FOR THE NATIONAL TOXICOLOGY PROGRAM. WASHINGTON.  DC.
                PNL-6833 UC-408.

                US EPA. 1991. RfD/RfC WORK GROUP.

METHYL ETHYL KETONE PEROXIDE                             001338-23-4
        010948  US EPA. 1993. RfD/RfC WORK GROUP.

METHYL ISOBUTYL KETONE                                    000108-10-1
        010949  MICROBIOLOGICAL ASSOCIATES.  1986. SUBCHRONIC  TOXICITY OF METHYL ISOBUTYL KETONE IN SPRAGUE-DAWLEY RATS.  PERFORMED FOR RESEARCH TRIANGLE
                INSTITUTE.  PO BOX 12194.  RESEARCH TRIANGLE  PARK. NC. 27709. FINAL REPORT  STUDY NO 522104

                US EPA. 1993. RfD/RfC WORK GROUP.

METHYL ISOCYANATE                                          000624-83-9
        010013  US EPA. 1986. HEALTH  AND ENVIRONMENTAL EFFECTS  PROFILE FOR METHYL ISOCYANATE  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1990. RfD/RfC WORK GROUP.
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                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995


METHYLMERCURY                                              022967-92-6
        010970  MARSH. O.O.. T.W. CLARKSON.  C.  COX  ET AL.   1987.  FETAL METHYLMERCURY POISONING:  RELATIONSHIP BETWEEN CONCENTRATION IN SINGLE STRANDS OF
                MATERNAL HAIR AND CHILD EFFECTS.  ARCH. NEUROL.  44: 1017-1022.

                SEAFOOD SAFETY.  1991.  COMMITTEE ON EVALUATION OF THE SAFETY OF FISHERY PRODUCTS. CHAPTER ON METHYLMERCURY: FDA RISK ASSESSMENT AND
                CURRENT REGULATIONS. NATIONAL ACADEMY PRESS. WASHINGTON. DC.  P. 196-221.

                U.S. EPA.   1980.  AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR MERCURY.  PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATION AND STANDARDS. WASHINGTON. DC.
                EPA/440/5-80/058.  NTIS PB 81-117699.

                U.S. EPA.  1995.  MERCURY STUDY REPORT TO CONGRESS.  OFFICE OF RESEARCH AND DEVELOPMENT.  WASHINGTON. DC.  EXTERNAL REVIEW DRAFT.
                EPA/600/P-94/002Ab.

                U.S. EPA.   1994.  RfD/RfC WORK GROUP.

METHYL METHACRYLATE                                       000080-62-6
        010014  BORZELLECA JF. PS LARSON. GR HENNIGAR. ET AL  1964. STUDIES ON THE CHRONIC ORAL TOXICITY OF  MONOMERIC  ETHYL ACRYLATE AND METHYL
                METHACRYLATE. TOXICOL APPL PHARMACOL. 6: 29-36.

                US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL METHACRYLATE  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF  SOLID WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.

METHYL PARATHION                                           000298-00-0
        010015  MONSANTO CO. 1983. ACCESSION NO 252501-252503. 253346. 253372-253374. MRID NO  000139023. 00143965. 00145507. AVAILABLE FROM  EPA  WRITE
                TO  FOI. EPA. WASHINGTON. DC 20460.

                US  EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL PARATHION  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF  SOLID WASTE. WASHINGTON. DC.

                US  EPA. 1986. RfD/RfC WORK GROUP.

        010846  DALY.  IW AND WE  RINEHART. 1980. A THREE-MONTH FEEDING STUDY OF METHYL PARATHION IN RATS. PROJECT 77-2054  MRID  NO.  74299  AVAILABLE FROM
                EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460.

                US  EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR METHYL PARATHION  PREPARED BY THE OFFICE  OF HEALTH  AND  ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF  SOLID WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.
                                                                                                                                                   Rl-67

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                                          REFERENCES FOR  HEAST TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              Nay 1995



STYRENE  (MIXED ISOMERS)                           025013-15-4
        010500   FINAL CHRONIC REPORT PERFORMED FOR THE NTP UNDER CONTRACT NO N01-ES-38042.

                 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR METHYL STYRENES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

METHYL-4-CHLOROPHENOXY)  BUTYRIC ACID. 4-(2-         000094-81-5
        010008   RHODIA. INC.  1970.  CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY.  MRID  NO 00116345. AVAILABLE FROM EPA. WRITE TO FOI  EPA
                 WASHINGTON. DC 20460.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR MCPA AND MCPB.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE. WASHINGTON.  DC.

                 US EPA. 1990. INTEGRATED RISK INFORMATION SYSTEM (IRIS). ONLINE. OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
                 AND ASSESSMENT OFFICE.  CINCINNATI. OH.

                •US EPA. 1987. RfD/RfC WORK GROUP.

METHYL-4-CHLOROPHENOXY)  PROPIONIC  ACID. 2-(2-          000093-65-2
        010009   BASF AKTIEGERELLSCHAFT.  1985. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY  MRID NO 00158359 AVAILABLE FROM EPA  WRITE TO FOI
                 EPA, WASHINGTON.  DC 20460.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR MCPP. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE. WASHINGTON.  DC.

                 US EPA. 1988. RfD/RfC WORK GROUP.

METHYL-4-CHLOROPHENOXYACETIC  ACID.  2-                  000094-74-6
        010007   INDUSTRY TASK FORCE ON MCPA  RESEARCH DATA.  1986. CONFIDENTIAL BUSINESS INFORMATION.  UNPUBLISHED STUDY. MRID NO 00164352  AVAILABLE FROM
                 EPA. WRITE TO FOI.  EPA.  WASHINGTON,  DC 20460.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR MCPA AND MCPB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE. WASHINGTON.  DC.

                 US EPA. 1988. RfD/RfC WORK GROUP.
                                                                                                                                                Rl-68

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                              (OTHER  THAN  CARCINOGEN1CITY)
                                                                                                                              Hay 1995
METHYLCYCLOHEXANE
        010431  KINKEAD ER. CC HAUN MG SCHNEIDER. ET AL.
                ANNOUNCEMENTS AND INDEX.  ISSUE 21. 29 P.
                                              000108-87-2
                                        1985.  CHRONIC INHALATION EXPOSURE OF EXPERIMENTAL ANIMALS TO METHYLCYCLOHEXANE.  GOVT REPORTS
                US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYLCYCLOHEXANE. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

METHYLENE BROMIDE                                          000074-95-3
        010501  KEYES DG. JW HENCK.  GC JERSEY. RJ KOCIBA. DJ SCHWETZ AND TO LANDRY   1982. METHYLENE BROMIDE: A 90-DAY REPEATED INHALATION TOXICITY STUDY
                IN RATS AND DOGS WITH A SUBSEQUENT TWO-YEAR HOLDING PERIOD FOR RATS. TOXICOLOGY RESEARCH LAB. HEALTH AND  ENVIRONMENTAL SCIENCES. DOW
                CHEMICAL CO.. MIDLAND. MI.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYLENE BROMIDE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

METHYLENE CHLORIDE  / (DICHLOROMETHANE)                000075-09-2
        005553  NATIONAL COFFEE ASSOCIATION.  1982. 24-MONTH CHRONIC TOXICITY AND ONCOGENICITY STUDY OF METHYLENE CHLORIDE IN RATS FINAL REPORT. PREPARED
                BY HAZLETON LABORATORIES AMERICA. INC..  VIENNA. VA. UNPUBLISHED

                US EPA. 1985. DRINKING WATER  CRITERIA DOCUMENT FOR METHYLENE CHLORIDE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.
        005552
US EPA.  1985.  RfD/RfC WORK GROUP.

NITSCHKE KD.  JD BUREK. TJ BELL. RJ KOCIBA.  LW RAMPEY AND MJ MCKENNA.
ONCOGENICITY  STUDY  IN RATS. FUND APPL TOXICOL.  10:  1-12.
1988.  METHYLENE  CHLORIDE: A 2-YEAR INHALATION TOXICITY AND
                US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR METHYLENE CHLORIDE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON.  DC.
METHYLENE-BIS(2-CHLOROANILINE). 4.41-                  000101-14-4
        010413  STULA EF. JR BARNES. H SHERMAN.  CF REINHARDY AND JA ZAPP.1977.
                (MOCA). J ENVIRON PATHOL TOXICOL. 1(1): 31-50.
                                                             URINARY BLADDER TUMORS IN DOGS FROM 4.41-METHYLENE-BIS(2-CHLOROANILINE)
                US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4.4'-METHYLENE-BIS(2-CHLOROANILINE). PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE. WASHINGTON DC.

        010933  US EPA. 1993. RfD/RfC WORK GROUP.
                                                                                                                                                  Rl-69

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                                           REFERENCES FOR HEAST  TABLE  1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGEN1CITY)
                                                                                                                                              Nay 1995
 METHYLENEDIPHENYL ISOCYANATE.  4.4-  / (DIPHENYLMETHANE  DIISOCYANATE)     000101-68-8
         010449  REUZEL PGJ  JHG ARTS. MHM  KUYPERS. ET AL.  1990. CHRONIC TOXICITY/CARCINOGENICITY  INHALATION STUDY OF POLYMERIC METHYLENEDIPHENYL
                 DIISOCYANATE AEROSOL IN RATS. FINAL REPORT. PREPARED BY CIVO INSTITUTE  FOR THE  INTERNATIONAL ISOCYAWE INSTITUTE.

                 REUZEL PGJ.  JHG ARTS. LG LOMAX. ET AL.  1998. CHRONIC INHALATION AND CARCINOGENICITY STUDY OF RESP1RABLE POLYMERIC METHYLENE DIPHENYL
                 DIISOCYANATE (POLYMERIC MOD AEROSOL IN RATS. FUND APPL TOXICOL.  22:  195-210                            "J-TntKiL ntmrLtNt UlHHtNYL

                 US EPA.  1993.  RfD/RfC WORK GROUP.

 METOLACHLOR                                                051218-45-2
         010950  TISDEL  M.  T  JACKSON. P MACWILLIAMS ET AL.  1983. TWO-YEAR CHRONIC  ORAL TOXICITY AND ONCOGENICITY STUDY WITH METOLACHLOR IN ALBINO RATS-
                 STUDY NO.  80030. FINAL REPORT.  (UNPUBLISHED STUDY RECEIVED MAY 24.  1983 UNDER 100-587  PREPARED BY HAZLETON RALTECH  INC   SUBMITTED BY
                 cS^f  IT" GREENSBOR0' NC:  CDL:250369-A. 250370.  250371. 250272. 259373. 259374.  259375.) REFERRED TO AS CIBA-GEIGY  1983 IN U S
                 EPA (1993).  MRID 00129377.  AVAILABLE FROM  EPA  WRITE TO FOI.  EPA. WASHINGTON. DC 20460.



                                                                                                                                                 N°-
                                                                               REFERRED T0 AS CIBA-GEIGY
1N
                                                                                                                       EPA (1993)  MR1D °0080897-
                 AUn  cuuiDnyycur.,  ,occccD "T™  °RINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METOLACHLOR. PREPARED BY THE OFFICE  OF  HEALTH
                 AND  ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF WATER. WASHINGTON.  DC.


METRIBUZIN                                                  021087-64-9
         010928   MOBAY CHEMICAL CORPORATION.  1974.  MRID 000061260.  AVAILABLE FROM EPA. WRITE TO FOI.  EPA.  WASHINGTON. DC 20460.

                 US EPA. 1986. RfD/RfC WORK GROUP.


                 US EPA. 1993. REVISED AND UPDATED  DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METRIBUZIN  PREPARED BY THE  OFFICE OF HEALTH
                 AND ENVIRONMENTAL EFFECTS. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH  FOR THE OFFICE OF WATER.  WASHINGTON  DC


MIREX                                                        002385-85-5
         010841   NTP (NATIONAL TOXICOLOGY PROGRAM).  1990.  TOXICOLOGY AND CARCINOGENESIS STUDIES OF MIREX  (CAS NO 2385-85-5) IN F344/N  RATS. (FEED
                 oIUUltoJ .  NIr IK t513.


                 US EPA.  1992. RFD/RFC WORK GROUP.
                                                                                                                                                Rl-70

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995



MOLINATE                                                    002212-67-1
        010017  STAUFFER CHEMICAL  COMPANY. 1981.  MRID NO  00079209. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON.  DC 20460.

                US EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MOLINATE.  PREPARED BY THE OFFICE OF HEALTH  AND  ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE. WASHINGTON. DC.

                US EPA. 1988. RfD/RfC WORK GROUP.

MOLYBDENUM                                                 007439-98-7
        010489  KOLVAL'SKIY VV  GA YAROVAYA AND DM SHMAVONYAN. 1961. CHANGES OF PURINE METABOLISM  IN MAN AND ANIMALS UNDER CONDITIONS OF MOLYBDENUM
                BIOGEOCHEMICAL PROVINCES. ZH OBSHCH BIOL. 22: 179-191. (IN RUSSIAN. TRANSLATION)

                US EPA. 1991. RfD/RfC WORK GROUP.

MONOCHLORAMINE                                             010599-90-3
        010517  NTP  (NATIONAL TOXICOLOGY  PROGRAM). 1990.  NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORINATED AND
                CHLORAMINATED WATER IN  F344/N RATS AND B6C3F1 MICE  (DRINKING WATER STUDIES).  NTP  TR 392. NATIONAL INSTITUTES OF HEALTH.

                US EPA 1992  DRINKING  WATER CRITERIA DOCUMENT  FOR  CHLORAMINES. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE HEALTH AND ECOLOGICAL CRITERIA DIVISION. OFFICE OF  SCIENCE AND
                TECHNOLOGY. OFFICE OF WATER. WASHINGTON.  DC.

                US EPA. 1992. RfD/RfC WORK GROUP.

NAPHTHOQUINONE. 1.4-                                      000130-15-4
        010020  US EPA 1986  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  1.4-NAPHTHOQUINONE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                 US EPA. 1991. RfD/RfC WORK GROUP.

NICKEL CYANIDE                                             000557-19-7
        010953   US EPA. 1993. RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-71

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                                          REFERENCES  FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN  CARCINOGEN1CITY)                                              May 1995



NICKEL. SOLUBLE SALTS                                    VARIOUS
        005579  AMBROSE.  AM.  DS  LARSON. JR BORZELLECA AND GR HENNIGAR.  JR.  1976. LONG-TERM TOXICOLOGIC ASSESSMENT OF NICKEL IN RATS AND DOGS. J GOOD SCI
                TECHNOL.  13:  181-187.

                US EPA.  1991.  DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR NICKEL. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
                OFFICE.  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

                US EPA.  1991.  RfD/RfC WORK GROUP.


NICOTINONITRILE                                           000100-54-9
        005584  US EPA.  1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE  CINCINNATI
                OH. OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON.  DC.

NITRIC OXIDE                                               010102-43-9
        010451  REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

                US EPA. 1994.  RfD/RfC WORK GROUP.

NITRITE                                                     014797-65-0
        010021  WALTON G.  1951.  SURVEY OF LITERATURE RELATING TO INFANT METHEMOGLOBINEMIA DUE TO NITRATE-CONTAMINATED WATER  AM J PUB HEALTH  41-
                986-996.

                US EPA.  1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITRITE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA.  1992.  RfD/RfC WORK GROUP.
                                                                                                                                               Rl-72

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)
                                                                                                                      May 1995
NITROANILINE.  2-
        010936   US EPA.
                                      000088-74-4
1992.  RfO/RfC WORK GROUP.
        010935  BIO/DYNAMICS  1983.  PROJECT NO. (BD-82-270).  A FOUR WEEK  INHALATION STUDY OF ORTHO-NITROANILINE IN MALE RATS. FINAL REPORT. SUBMITTED TO
                OR. .RASHMI NAIR.  MONSANTO CO.. AUGUST 16. 1983.  EPA 87821478. #OTS0206486  P  1A-17. 32-42.  46-48.  55-58. 62-67.

                US EPA. 1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR NITROANILINE (0-. M-. P-). PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA  1991  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-NITROANILINE  PREPARED BY THE OFFICE OF  HEALTH AND  ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.

NITROANILINE.  M-                                           000099-09-2
        010400  US EPA  1991  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 3-NITROANILINE  PREPARED BY THE OFFICE OF  HEALTH AND  ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.

NITROANILINE.  P-                                           000100-01-6
        010024  US EPA. 1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROANILINE  (0-. M-. P-)  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

NITROBENZENE                                                000098-95-3
        005589  CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1984. NINETY-DAY INHALATION STUDY OF NITROBENZENE IN F-344 RATS.  CD  RATS AND  B6C3F1
                MICE WITH COVER LETTER DATED 6/24/84 AND EPA RESPONSE DATED 8/06/84.  UNPUBLISHED STUDY  FYI-OTS-0784-0333 AND COMPUTER PRINT-OUT OF
                PATHOLOGY FINDING.

                US EPA  1987  HEALTH EFFECTS ASSESSMENT  FOR NITROBENZENE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND  REMEDIAL RESPONSE. WASHINGTON.  DC.

                US EPA. 1985. RfD/RfC WORK GROUP.

NITROFURANTOIN                                             000067-20-9
        005593  SRI  (SOUTHERN RESEARCH INSTITUTE).  1980. SUBCHRONIC TOXICITY REPORT ON  NITROFURANTOIN  (C55196)  IN  FISCHER-344 RATS AND B6C3F1 MICE.
                TRACOR JIT CO. INC. ROCKVILLE. MD.  CONTRACT NOS  N01-CP-43350 AND 78-65-106002  US EPA
                                                     s
                US  EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITROFURANS.  PREPARED  BY THE  OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.
                                                                                                                                                  Rl-73

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER  THAN CARCINOGEN1CITY)                                              May 1995



NITROGEN DIOXIDE                                           010102-44-0
         010402   US EPA.  1994. RfD/RfC WORK GROUP.

         010912   REFER TO APPENDIX A: TECHNICAL  INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

NITROGEN OXIDES
         010170   US EPA.  1982. AIR QUALITY CRITERIA FOR OXIDES OF  NITROGEN. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  RESEARCH TRIANGLE PARK  NC   EPA
                 600/8-82-026F. NTIS PB83-163337.

NITROMETHANE                                                000075-52-5
         010026   US EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE. WASHINGTON.  DC.

NITROPHENOLS
         005594   US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR NITROPHENOLS. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC.

NITROPROPANE.  2-                                           000079-46-9
         010374   ANGUS CHEMICAL CO.  1985.  FINAL  REPORT  CHRONIC INHALATION EXPOSURE TO RATS TO VAPORS OF  2-NITROPROPANE AT 100 PPM  PREPARED BY  COULSTON
                 INTERNATIONAL CORP FOR ANGUS CHEMICAL CO  OTS NO  204292.  DOC NO 8EHQ-0985-0170  FICHE NO 0200504.

                 ANGUS CHEMICAL CO.  1985.  CHRONIC INHALATION OF 200 PPM OF2-NITROPROPANE IN RATS  PREPARED BY COULSTON INTERNATIONAL CORP (MAY  1978) FOR
                 ANGUS CHEMICAL CO.  OTS NO 204292. DOC NO 8EHQ-0985-0170.  FICHE NO 0200504

                 GRIFFIN  TB. F COULSTON AND AA STEIN. 1980. CHRONIC INHALATION EXPOSURE OF RATS TO VAPORS OF 2-NITROPROPANE AT 25 PPM  ECOTOXICOL ENVIRON
                 SAF.  4(3): 267-281.

                 GRIFFIN  TB. AA STEIN.  F COULSTON. 1981.  HISTOLOGICAL  STUDY OF TISSUES AND ORGANS FROM RATS  EXPOSED TO VAPORS OF 2-NITROPROPANE  AT 25 PPM
                 ECOTOXOCOL ENVIRON SAF.  5(2): 194-201.

                 US EPA   1990. RfD/RfC WORK GROUP.


NITROSODIPHENYLAMINE. P-                                  000156-10-5
        010027   US EPA   1986. HEALTH AND  ENVIRONMENTAL  EFFECTS PROFILE FOR NITROSAMINES  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE  AND EMERGENCY RESPONSE.  WASHINGTON.  DC.
                                                                                                                                                Rl-74

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                                          REFERENCES  FOR  HEAST  TABLE  1:   SUBCHRONIC  AND  CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGEN1CITY)                                               May 1995


NITROTOLUENE.  M-                                           000099-08-1
        010029   CISS M. N HUYEN.  H DUTERTRE. N PHU-LICH AND R TRUHAUT. 1980. TOXICOLOGICAL STUDY OF NITROTOLUENES  LONG-TERM TOXICITY   DAKAR MEDICAL. 25.
                 293-302.

                 US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROTOLUENES (0-.  M-.  P-)   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

NITROTOLUENE.  0-                                           000088-72-2
        010028   CISS M. N HUYEN.  H DUTERTRE. N PHU-LICH AND R TRUHAUT. 1980. TOXICOLOGICAL STUDY OF NITROTOLUENES. LONG-TERM TOXICITY.  DAKAR MEDICAL. 25:
                 293-302.

                 US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROTOLUENES (0-.  M-.  P-)   PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

NITROTOLUENE.  P-                                           000099-99-0
        010030   CISS M. N HUYEN.  H DUTERTRE. N PHU-LICH AND R TRUHAUT. 1980. TOXICOLOGICAL STUDY OF NITROTOLUENES: LONG-TERM TOXICITY  DAKAR MEDICAL. 25:
                 293-302.

                 US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROTOLUENES (0-.  M-. P-)   PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

OCTABROMODIPHENYL  ETHER                                  032536-52-0
        010032   CARLSON GP. 1980. INDUCTION OF XENOBIOTIC METABOLISM IN  RATS BY  BROMINATED DIPHENYL ETHERS  ADMINISTERED FOR 90  DAYS. TOXICOL LETT  6:
                 207-212.

                 US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE. WASHINGTON. DC

                 US EPA. 1986.  RfD/RfC WORK GROUP.

OCTAMETHYLPYROPHOSPHORAMIDE                             000152-16-9
        010031   RIDER  JA. HC MOELLER, EJ PULETTI AND JI SWADER. 1969. TOXICITY OF PARATHION. SYSTOX. OCTAMETHYLPYROPHOSPHORAMINE AND METHYL PARATHION IN
                 MAN. TOXICOL APPL PHARMACOL.  14(3): 603-611.

                 US EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  OCTAMETHYLPYROPHOSPHORAMIDE  PREPARED  BY THE  OFFICE OF  HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID  WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON. DC.


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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN  CARCINOGENICITY)                                              Nay 1995


OSMIUM TETROXIDE                                           020816-12-0
         010954  US EPA.  1993. RfD/RfC WORK GROUP.

OZONE                                                        010028-15-6
         010171  US EPA.  1986. AIR QUALITY CRITERIA FOR OZONE AND OTHER PHOTOCHEMICAL OXIDANTS  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  RESEARCH
                 TRIANGLE PARK. NC. EPA 600/8-84-020F. NTIS PB87-142949.

PARALDEHYDE                                                 000123-63-7
         010033  US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  PARALDEHYDE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

PARATHION                                                   000056-38-2
         005598  US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR PARATHION.  PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON.  DC.

PARTICULATE  MATTER
         010034  US EPA.  1987. AIR QUALITY CRITERIA FOR PARTICULATE MATTER AND SULFUR OXIDES  OFFICE OF HEALTH AND'ENVIRONMENTAL ASSESSMENT  RESEARCH
                 TRIANGLE PARK, NC. EPA 600/8-82-029F.NTIS PB84-156777.

PEBULATE                                                    001114-71-2
         010036  US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  PEBULATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

PENDIMETHALIN  '                                            040487-42-1
         010037  AMERICAN CYANAMID COMPANY. 1979. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 0058657  AVAILABLE  FROM EPA  WRITE TO FOI
                 EPA. WASHINGTON.  DC 20460.                                                                          '                  '

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR  PENDIMETHALIN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.

                 US EPA. 1987. RfD/RfC WORK GROUP.

PENTABROMODIPHENYL  ETHER                                 032534-81-9
         010038   CARLSON GP.  1980.  INDUCTION OF XENOBIOTIC  METABOLISM IN RATS BY BROMINATED DIPHENYL  ETHERS ADMINISTERED FOR  90 DAYS  TOXICOL LETT  6-
                 207-212.

                 US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS PREPARED BY  THE OFFICE  OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE.  WASHINGTON. DC.

                US EPA. 1986.  RfD/RfC WORK GROUP.


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                                          REFERENCES FOR HEAST  TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995


PENTACHLOROBENZENE                                         000608-93-5
        010039  LINGER R. T SCOTTI  J  GOLDSTEIN AND K MCELROY.  1980.  ACUTE AND SUBCHRONIC TOXICITY OF PENTACHLOROBENZENE.  J ENVIRON  PATHOL TOXICOL.
                4(5-6): 183-196.

                US EPA. 1989. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PENTACHLOROBENZENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1985. RfD/RfC WORK GROUP.

PENTACHLOROCYCLOPENTADIENE                               025329-35-5
        005302  US EPA. 1988. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE. WASHINGTON. DC.

PENTACHLORONITROBENZENE                                   000082-68-8
        010040  OLIN CORPORATION.  1968. MRID NO. 000114201.  AVAILABLE  FROM EPA. WRITE TO FOI.  EPA. WASHINGTON. DC 20460.

                US EPA. 1986. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR PENTACHLORONITROBENZENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI.  OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1987. RfD/RfC WORK GROUP.

PENTACHLOROPHENOL                                          000087-86-5
        005600  SCHWETZ. BA.  JF QUAST. PA KEELER ET AL. 1978.  RESULTS  OF TWO-YEAR TOXICITY AND REPRODUCTION STUDIES ON PENTACHLOROPHENOL  IN  RATS.  IN:
                PENTACHLOROPHENOL:  CHEMISTRY. PHARMACOLOGY AND ENVIRONMENTAL TOXICOLOGY. KR RAO. ED   PLENUM PRESS. NEW YORK. P301.  CITED  IN  US  EPA. 1985.

                US EPA. 1986. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR  PENTACHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI.  OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1984. HEALTH  EFFECTS ASSESSMENT FOR PENTACHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON,  DC

                US EPA. 1985. RfD/RfC WORK GROUP.

PENTACHLOROPROPENE,  1.1.2.3.3.-                         001600-37-9
        010041  US EPA. 1983. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR  CHLOROPROPENES. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.


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                                                               (OTHER THAN CARCINOGENICITY)                                              May 1995



 PENTANE. N-                                                 000109-66-0
         005603  US EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR N-PENTANE. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE   CINCINNATI  OH  OFFICE OF EMERGENCY
                 AND REMEDIAL RESPONSE. WASHINGTON.  DC.


 PHENANTHRENE                                               000085-01-8
         005604  US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENANTHRENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA.  1994. RfD/RfC WORK GROUP.


 PHENOL                                                       000108-95-2
         005824  NTP (NATIONAL TOXICOLOGY PROGRAM).  1983. TERATOLOGIC EVALUATION  OF  PHENOL IN CD RATS  REPORT PREPARED BY THE RESEARCH TRIANGLE INSTITUTE
                 RESEARCH TRIANGLE PARK. NC. NTIS PB83-247726. GOVT REP ANNOUNCE  INDEX  83(25). 6247

                 US EPA.  1989. UPDATED HEALTH EFFECTS  ASSESSMENT FOR PHENOL.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH.  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

                 US EPA.  1989. RfD/RfC WORK GROUP.

         010913  US EPA.  1990. RfD/RfC WORK GROUP.


 PHENYLENEDIAHINE.  M-                                      000108-45-2
         010044  HOFER H  AND R HRUBY. 1982.  NINETY-DAY TOXICITY STUDY WITH  M-PHENYLENEDIAMINE ON RATS  OESTERR FORSCHUNGS ZENT SEIBERSDORF (BER ) OEFZS
                 BER. NO. 4155.  P 50.


                 US EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0-  M-   P-)   PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON.  DC.

                 US EPA.  1986. RfD/RfC WORK GROUP.


PHENYLENEDIAMINE. 0-                                      000095-54-5
         010042   US EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0-.  M-.  P-)   PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON.  DC.


PHENYLENEDIAMINE. P-                                      000106-50-3
         010043   US  EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0-   M-   P-)   PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON.  DC.



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                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995


PHENYLMERCURIC ACETATE                                    000062-38-4
         010277   FITZHUGH  OG. AA NELSON. EP LAUG AND IM KUNZE.  1950. CHRONIC ORAL TOXICITIES OF MERCURIC PHENYL AND MERCURIC SALTS.  ARCH  IND  HYG OCCUP
                 MED.  2: 433-442.

                 US  EPA. 1986. RfD/RfC WORK GROUP.

PHORATE                                                      000298-02-2
         010403   TUSING TW.  1956. 13-WEEK SUBACUTE  THIMET FEEDING STUDY IN MALE AND FEMALE RATS.  UNPUBLISHED REPORT OF THE AMERICAN  CYANAMID  CO  INITIAL
                 SCIENTIFIC AND MINI-ECONOMIC REVIEW OF PHORATE  (THIMET).  OFFICE OF PESTICIDE PROGRAMS. US EPA. WASHINGTON. DC.

                 US  EPA. 1985. SUMMARY OF ACCEPTABLE DAILY INTAKES (ADIS)  FOR ORAL EXPOSURE  PREPARED BY ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE.
                 CINCINNATI. OH. INTERNAL REVIEW DRAFT. MAY, 1985. ECAO-CIN-432.

                 NAS (NATIONAL ACADEMY OF SCIENCES).  1977.  DRINKING WATER AND HEALTH.  SAFE DRINKING WATER COMMITTEE. NATIONAL RESEARCH COUNCIL  NAS.
                 WASHINGTON. DC. P 613-620.

PHOSGENE                                                      000075-44-5
         010045   US  EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR PHOSGENE.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE. WASHINGTON. DC.

                 US  EPA. 1990. RfD/RfC WORK GROUP.

PHOSPHINE                                                    007803-51-2
         010174   HACKENBERG. J. 1972.  CHRONIC INGESTION BY RATS  OF STANDARD DIET TREATED WITH ALUMINUM PHOSPHIDE. TOXICOL APPL PHARMACOL   23: 147-158.

                 US  EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR PHOSPHINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US  EPA. 1985. RfD/RfC WORK GROUP.

         010173   KLIMMER. OR. 1969.  CONTRIBUTION TO THE STUDY OF ACTION OF PHOSPHINE (PH3)  ON  THE QUESTION OF SO-CALLED CHRONIC PHOSPHINE POISONING  ARCH
                 TOXICOL. 24: 164-187.

                 US  EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR PHOSPHINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC
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                                                              (OTHER THAN CARCINOGEN1CITY)                                              May 1995


PHOSPHORUS. WHITE                                          007723-14-0
        010452  CONDRAY JR. 1985.  ELEMENTAL YELLOW PHOSPHORUS ONE-GENERATION REPRODUCTION STUDY  IN RATS. IR-82-215 MRID  NO  401-189  MONSANTO CO  ST
                LOUIS. MO. AVAILABLE FROM EPA. WRITE TO FOI.  EPA. WASHINGTON. DC 20460

                US EPA. 1990.  RfD/RfC WORK GROUP.

PHOTOCHEMICAL OXIDANTS
        010172  US EPA. 1986.  AIR  QUALITY CRITERIA FOR OZONE  AND OTHER PHOTOCHEMICAL OXIDANTS  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  RESEARCH
                TRIANGLE PARK. NC.  EPA 600/8-84-020F. NTIS PB87-142949.

PHTHALIC  ACID.  M-                                          000121-91-5
        010047  US EPA. 1986.  HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACIDS. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC

PHTHALIC  ACID.  0-                                          000088-99-3
        010046  US EPA. 1986.  HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACIDS. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

PHTHALIC  ACID.  P-                                          000100-21-0
        010048  CUT (CHEMICAL INDUSTRY INSTITUTE OF TECHNOLOGY). 1982. A NINETY-DAY STUDY OF  TEREPHTHALIC ACID-INDUCED  UROLITHIASIS AND REPRODUCTIVE
                PERFORMANCE IN WISTAR AND CD RATS. CUT.  RESEARCH TRIANGLE PARK.  NC

                GROSS. J.  1974.  THE  EFFECTS OF PROLONGED FEEDING OF TEREPHTHALIC ACID (TPA) TO RATS  PROJECT FG-IS-175   AGRICULTURAL RESEARCH SERVICE  US
                DEPARTMENT OF  AGRICULTURE. WASHINGTON.  DC.

                US EPA. 1986.  HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACIDS  (0-.  M-. P-).  PREPARED BY THE  OFFICE OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE.  WASHINGTON.  DC.
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                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995



PHTHALIC  ANHYDRIDE                                         000085-44-9
        010049  NCI (NATIONAL CANCER INSTITUTE). 1979.  BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY  NCI  CARCINOGENESIS  TECH REP SER NO.
                159. NTIS PB293594.

                US EPA. 1988. RfD/RfC WORK GROUP.

        010847  NIELSEN. J. H WELINDER.  A SCHUTZ AND S SKERFVING  1988  SPECIFIC  SERUM ANTIBODIES AGAINST  PHTHALIC ANHYDRIDE IN OCCUPATIONALLY  EXPOSED
                SUBJECTS. J ALLERGY CLIN IMMUNOL. 82: 126-33

                US EPA  1992  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  PHTHALIC ANHYDRIDE  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

POlYBROMINATED BIPHENYLS
        010050  NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. CARCINOGENESIS STUDIES  OF POLYBROMINATED BIPHENYL  MIXTURE  IN F344/N RATS AND B6C3F1  MICE  (GAVAGE
                STUDIES). FIREMASTER FF-1.  CASE  NO 67774-32-7  NTP.  RESEARCH TRIANGLE PARK. NC.

                US EPA  1989  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  POLYBROMINATED BIPHENYLS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

POTASSIUM CYANIDE                                          000151-50-8
        010278  HOWARD  JW AND RF HANZAL. 1955.  CHRONIC TOXICITY FOR RATS OF  FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.

                 PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON.  1979. EFFECTS OF PROLONGED CYANIDE  AND THIOCYANATE  FEEDING IN RATS.  J
                TOXICOL ENVIRON HEALTH.  5.  579-592.

                 US  EPA.  1985. RfD/RfC WORK GROUP.

POTASSIUM SILVER CYANIDE                                 000506-61-6
        010279   HOWARD  JW AND RF HANZAL. 1955.  CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH  HYDROGEN CYANIDE. AGRIC  FOOD  CHEM. 3. 325-329

                 PHILBRICK  DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON.  1979  EFFECTS  OF PROLONGED CYANIDE AND THIOCYANATE  FEEDING IN RATS.  J
                 TOXICOL ENVIRON HEALTH.  5:  579-592

                 US  EPA.  1985. RfD/RfC WORK GROUP.

PROFLURALIN                                                  026399-36-0
        010051   US  EPA  1984 HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR PROFLURALIN  PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.


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                                                              (OTHER THAN  CARCINOGENICITY)                                              May 1995


PRONAHIDE                                                  023950-58-5
        010280  ROHM & HAAS.  CO.  1970. ACC NOS 000967.  004417.

                US EPA. 1986.  RfD/RfC WORK GROUP.

PROPACHLOR                                                 001918-16-7
        010175  MONSANTO COMPANY.  1964. CONFIDENTIAL BUSINESS INFORMATION UNPUBLISHED STUDY  MRID NO 0093270. AVAILABLE FROM EPA  WRITE TO FOI  EPA
                WASHINGTON. DC 20460.

                US EPA. 1984.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR PROPACHLOR  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA. 1986.  RfD/RfC WORK GROUP.

PROPAZINE                                                  000139-40-2
        010052  GEIGY COMPANY.  1980. CONFIDENTIAL  BUSINESS INFORMATION. UNPUBLISHED STUDY  ACCESSION NO 243353.

                US EPA. 1987.  RfD/RfC WORK GROUP.


PROPIONITRILE                                              000107-12-0
        010053  US EPA. 1985.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR PROPIONITRILE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

PROPYL ALCOHOL.  N-                                        000071-23-8
        005627  US EPA. 1987.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR N-PROPYL ALCOHOL  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.
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                                                              (OTHER THAN CARCINOGEN1CITY)                                               May 1995


PROPYLENE GLYCOL                                           000057-55-6
        005631  GAUNT. IF. RMB CARPANINI.  P GRASSO AND ABG LANSDOWN.  1972. LONG-TERM TOXICITY OF PROPYLENE  GLYCOL  IN RATS  FOOD COSMET TOXICOL  10.
                151-162.

                US EPA. 1987  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PROPYLENE GLYCOL  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.


        005629  GUERRANT. NB.  GP WHITLOCK. ML WOLFF AND RA DUTCHER.  1947.RESPONSE OF RATS TO DIETS  CONTAINING VARYING AMOUNTS OF GLYCEROL AND PROPYLENE
                GLYCOL. BULL NATL FORMULARY COMM  15: 204-229. CITED IN  INFORMATICS. INC. 1973

                US EPA. 1987  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PROPYLENE GLYCOL  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

        010914  US EPA. 1991.  RfD/RfC WORK GROUP.

PROPYLENE GLYCOL MONOETHYL ETHER                        001569-02-4
        005488  SMYTH. HF. JR AND CP CARPENTER. 1948. FURTHER EXPERIENCE WITH THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY. J IND  HYG
                TOXICOL.  30: 63-68.

                US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON. DC.

        010915  US EPA. 1991.  RfD/RfC WORK GROUP.
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                                           REFERENCES  FOR HEAST  TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGEN1CITY)                                               May 1995



PROPYLENE GLYCOL  MONOMETHYL ETHER                       000107-98-2
         005486   ROME.  VK. DO MCCOLLISTER. HC SPENCER ET  AL.  1954. TOXICOLOGY OF MONO-. DI-.  AND TRI-PROPYLENE  GLYCOL METHYL ETHERS ARCH IND HYG OCCUR
                 MED. 9:  509-525.

                 US EPA.  1984. HEALTH EFFECTS ASSESSMENT  FOR  GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC  EPA 540/1-86-052.

                 US EPA.  1991. RfD/RfC WORK GROUP.

         010276   LANDRY TO. TS GUNSHOW AND BL YANO.  1983.  PROPYLENE GLYCOL MONOMETHYL ETHER.  A 13-WEEK INHALATION STUDY  IN RATS AND RABBITS  FUND APPL
                 TOXICOL. 3: 627-630.

                 MILLER RR. EA HERMAN. JT YOUNG ET AL.  1984.  ETHYLENE GLYCOL MONOMETHYL ETHER  METABOLISM.  DISPOSITION. AND SUBCHRONIC INHALATION TOXICITY
                 STUDIES. ENVIRON HEALTH PERSPECT.  57:  233-239.

                 US EPA.  1984  HEALTH EFFECTS ASSESSMENT  FOR  GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE, CINCINNATI.  OH. FOR THE OFFICE OF EMERGENCY  AND REMEDIAL  RESPONSE. WASHINGTON. DC. EPA 540/1-86-052.

PROPYLENE OXIDE                                             000075-56-9
         010375   KUPER  CF. PGJ REUZEL, VJ FERON. ET AL. 1988  CHRONIC INHALATION TOXICITY AND CARCINOGENICITY OF PROPYLENE OXIDE IN WISTAR RATS  FOOD CHEM
                 TOXICOL. 26(2): 159-167.

                 US EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR PROPYLENE OXIDE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1990. RfD/RfC WORK GROUP.

PYRENE                                                        000129-00-0
         010176   US EPA.  1989. MOUSE ORAL SUBCHRONIC TOXICITY STUDY OF PYRENE. STUDY CONDUCTED BY TOXICITY  RESEARCH LABORATORIES  MUSKEGON  3MI FOR  THE
                 OFFICE OF SOLID WASTE.  WASHINGTON,  DC.

                 US EPA.  1984. HEALTH EFFECTS ASSESSMENT  FOR  PYRENE. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
                 AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA.  1991. DRINKING WATER CRITERIA  DOCUMENT  FOR PYRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF DRINKING WATER.  WASHINGTON. DC.

                 US EPA.  1989. RfD/RfC WORK GROUP.

         010968  US EPA. 1994.  RfD/RfC WORK GROUP.


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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               Hay 1995


PYRIDINE                                                    000110-86-1
        010055   US EPA. 1986. PYRIDINE.  90-DAY  SUBCHRONIC ORAL TOXICITY IN RATS.  SPONSORED BY OFFICE OF SOLID WASTE.  WASHINGTON.  DC.

                 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PYRIDINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE. WASHINGTON.  DC.

                 US EPA. 1987. RfD/RfC WORK GROUP.

RDX / (CYCLONITE)                                          000121-82-4
        010056   LEVINE BS. EM FUREDI. VS RAE. DE GORDON AND DM LISH. 1984. DETERMINATION  OF THE CHRONIC MAMMALIAN TOXICOLOGICAL EFFECTS  OF RDX:
                 TWENTY-FOUR MONTH CHRONIC TOXICITY/CARCINOGENICITY STUDY OF HEXAHYDRO-1.3.5-TRINITRO-1.3.5-TRIAZINE (RDX) IN THE FISCHER 344  RAT. NTIS
                 AD-A160774. VOL 1. 347 P.

                 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR RDX (CYCLONITE). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA. 1988. RfD/RfC WORK GROUP.

RONNEL                                                       000299-84-3
        010057   MCCOLLISTER DO. F OYEN AND VK ROWE. 1959. TOXICOLOGICAL STUDIES OF 0.0-DIMETHYL-0-(2.4.5-TRICHLOROPHENYL)PHOSPHOTHIOATE  (RONNEL)  IN
                 LABORATORY ANIMALS. J AGRIC FOOD CHEM. 7: 689.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR RONNEL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  "OH FOR THE  OFFICE OF SOLID WASTE. WASHINGTON.  DC.

SELENIOUS ACID                                             007783-00-8
        010504   YANG G. S YIN. L ZHOU. ET AL. 1989. STUDIES OF SAFE MAXIMAL DAILY DIETARY SE-INTAKE IN A SELENIFEROUS AREA IN CHINA. II. RELATION BETWEEN
                 SE-INTAKE AND THE MANIFESTATION OF CLINICAL SIGNS AND CERTAIN BIOCHEMICAL ALTERATIONS IN BLOOD AND URINE. J TRACE ELEM.  ELECTROLYTES
                 HEALTH DIS. 3: 123-130.

                 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELENIUM  AND  COMPOUNDS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON
                 DC.

                 US EPA. 1991. RfD/RfC WORK GROUP.
                                                                                                                                                  Rl-85

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER  THAN  CARCINOGENICITY)                                              May 1995


SELENIUM                                                    007782-49-2
        010404  YANG G. S YIN. L ZHOU.  ET AL.  1989. STUDIES OF SAFE MAXIMAL DAILY  DIETARY SE-INTAKE IN A SELENIFEROUS AREA  IN CHINA. II  RELATION BETWEEN
                SE-INTAKE AND THE MANIFESTATION OF CLINICAL SIGNS AND CERTAIN  BIOCHEMICAL ALTERATIONS IN BLOOD AND URINE  J TRACE ELEM ELECTROLYTES
                HEALTH DIS. 3: 123-130.

                US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR SELENIUM AND COMPOUNDS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1991. RfD/RfC WORK GROUP.

SELENOUREA                                                  000630-10-4
        010473  YANG C. S WANG. R ZHOU.  AND S  SUN. 1983. ENDEMIC SELENIUM INTOXICATION OF HUMANS IN CHINA  AM J CLIN NUTR.  37: 872-888.

SILVER                                                       007440-22-4
        010453  GAUL LE AND AN STAUD. 1935.  CLINICAL SPECTROSCOPY.  SEVENTY CASES OF GENERALIZED ARGYRIA FOLLOWING ORGANIC AND COLLOIDAL SILVER
                MEDICATION. J AM MED ASSOC  104:  1387-1390.

                BLUMBERG H AND TN CAREY.  1934. ARGYREMIA: DETECTION OF UNSUSPECTED AND OBSCURE ARGYRIA BY THE  SPECTROGRAPHIC DEMONSTRATION OF HIGH BLOOD
                SILVER. J AM MED ASSOC.  103  1521-1524.

                EAST BW. K BODDY. ED WILLIAMS. D  MACINTYRE AND ALC MCLAY.1980.  SILVER RETENTION, TOTAL BODY SILVER AND TISSUE SILVER CONCENTRATIONS IN
                ARGYRIA ASSOCIATED WITH EXPOSURE  TO AN ANTI-SMOKING REMEDY CONTAINING SILVER ACETATE  CLIN EXP DERMATOL. 5: 305-311.

SILVER CYANIDE                                              000506-64-9
        010283  HOWARD JW AND RF HANZAL  1955  CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE  AGRIC FOOD CHEM  3: 325-329

                PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON 1979  EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS  J
                TOXICOL ENVIRON HEALTH.  5: 579-592.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR SODIUM CYANIDE. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  OFFICE OF
                EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON. DC

                US EPA. 1985. RfD/RfC WORK GROUP.

SIMAZINE                                                    000122-34-9
        010955  CIBA-GEIGY CORP.  1988.  MRID NO 40614405, HED DOCUMENT NO 007240. 007449  AVAILABLE FROM EPA  WRITE TO FOI. EPA. WASHINGTON. DC 20460.

                US EPA. 1991. RfD/RfC WORK GROUP.
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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER  THAN CARCINOGENICITY)                                              Hay 1995


SODIUM  CYANIDE                                             000143-33-9
         005640   HOWARD. JW AND RF HANZAL.  1955. CHRONIC TOXICITY  FOR RATS  OF FOOD TREATED WITH HYDROGEN CYANIDE.  J AGRIC  FOOD CHEM. 3. 325-329 CITED IN
                 US  EPA. 1985.

                 US  EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR SODIUM CYANIDE. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  OFFICE OF
                 EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC.

                 US  EPA. 1985. INTEGRATED RISK  INFORMATION SYSTEM  (IRIS): REFERENCE DOSE (RFD) FOR ORAL EXPOSURE FOR  SODIUM CYANIDE. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH.

                 US  EPA. 1985. RfO/RfC WORK GROUP.

SODIUM  DIETHYLDITHIOCARBAMATE                           000148-18-5
         005644   SUNDERMAN. FW. OE PAYNTER AND  RB GEORGE. 1967.  THE EFFECTS OF THE PROTRACTED ADMINISTRATION OF THE CHELATING AGENT. SODIUM
                 DIETHYLDITHIOCARBAMATE (DITHIOCARB). AM J MED SCI. 254:  46-56.

                 US  EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR SODIUM DIETHYLOITHIOCARBAMATE.  PREPARED  BY  THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON.  DC.

                 US  EPA. 1985. RfD/RfC WORK GROUP.

SODIUM  METAVANADATE                                       013718-26-8
         005735   DOMINGO. JL. JL LLOBET,  JM TOMAS AND J CORBELLA.  1985. SHORT-TERM TOXICITY STUDIES OF VANADIUM IN RATS  J APPL TOXICOL. 5(6): 418-421.

                 US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF  HEALTH AND  ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

STRONTIUM.  STABLE                                          007440-24-6
         010842   STOREY E. 1961.  STRONTIUM 'RICKETS1 BONE CALCIUM  AND STRONTIUM CHANGES. AUSTRAL ANN MED. 10:  2132-222.

                 SKORYNA SC.  1981.  EFFECTS  OF ORAL SUPPLEMENTATION WITH STABLE STRONTIUM. CAN MED ASSOC J.  125: 703-712.

                 MARIE PJ. MT GARBA. M HOTT AND L MIRAVET. 1985. EFFECT OF  LOW DOSES OF STABLE STRONTIUM ON BONE METABOLISM  IN RATS. MINER ELECTROLYTE
                 METAB. 11: 5-13.

                 US  EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR STABLE STRONTIUM. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.

                 US  EPA. 1992. RfD/RfC WORK GROUP.


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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER  THAN  CARCINOGEN1CITY)                                              May 1995


STRYCHNINE                                                  000057-24-9
        010285  SEIOL I AND G ZBINDEN.  1982.  SUBCHRONIC ORAL TOXICITY OF STRYCHNINE IN RATS  ARCH TOXICOL.  51(3):  267-271.

                US EPA. 1985. RfD/RfC WORK GROUP.

STYRENE                                                      000100-42-5
        010059  QUAST JF. CG HUMISTON.  RT KALNINS. ET AL. 1979.  RESULTS  OF A TOXICITY STUDY OF MONOMERIC STYRENE ADMINISTERED TO BEAGLE DOGS BY ORAL
                INTUBATION FOR 19 MONTHS.  TOXICOLOGY RESEARCH LABORATORY.  HEALTH AND ENVIRONMENTAL SCIENCES. DOW CHEMICAL CO . MIDLAND. MI.  FINAL REPORT.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STYRENE. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE.  WASHINGTON. DC

                US EPA  1985. RfD/RfC WORK GROUP

        010511  MUTTI A. A MAZZUCCHI. P RUSTICHELLI. G FRIZERI.  G ARFINI.  I FRANCHINI. 1984  EXPOSURE EFFECT AND EXPOSURE RESPONSE  THE RELATIONSHIP
                BETWEEN OCCUPATIONAL EXPOSURE TO STYRENE AND NEUROPSYCHOLOGICAL FUNCTION  AMER J IND MED  5: 275-286.

                US EPA. 1992. RfD/RfC WORK GROUP.

SUCCINONITRILE                                              000110-61-2
        005585  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR SELECTED NITRILES  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

SULFUR DIOXIDE                                              007446-09-5
        010505  REFER TO APPENDIX A: TECHNICAL  INFORMATION.  SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

SULFUR OXIDES
        010035  US EPA. 1987. AIR QUALITY CRITERIA FOR PARTICULATE MATTER AND  SULFUR OXIDES  OFFICE OF HEALTH  AND  ENVIRONMENTAL ASSESSMENT.  RESEARCH
                TRIANGLE PARK. NC. EPA 600/8-82-029F.NTIS PB84-156777.

SULFURIC  ACID                                               007664-93-9
        005647  CARSON. BL. BL HERNDON.  HV ELLIS III. ET AL. 1981.  SULFURIC ACID HEALTH EFFECTS  PREPARED UNDER CONTRACT 68-03-2928 BY MIDWEST  RESEARCH
                INSTITUTE. KANSAS CITY.  MO. PREPARED FOR EMISSION CONTROL TECHNOLOGY DIVISION.  OFFICE OF MOBILE SOURCE AIR POLLUTION CONTROL US EPA. ANN
                ARBOR. MI. EPA 460/3-81-025.  NTIS PB82-113135

                US EPA. 1984. HEALTH EFFECTS  ASSESSMENT FOR SULFURIC ACID. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH.  OFFICE OF
                EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC.

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                                          REFERENCES  FOR HEAST  TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995


TEMEPHOS                                                    003383-96-8
         010060  GAINES TB. RD KIMBROUGH AND ER LAW.  JR.  1967.  TOXICOLOGY OF ABATE IN LABORATORY ANIMALS  ARCH ENVIRON  HEALTH. 14: 283-288

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEMEPHOS. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE. WASHINGTON.  DC.

TERBUFOS                                                    013071-79-9
         010408  MORGAREIDGE K. S SISTNER. M DANIELS ET AL.  1973. FINAL REPORT: SIX-MONTH FEEDING STUDY IN DOGS ON AC-92.100. LABORATORY NO. 1193.
                FEBRUARY 14. UNPUBLISHED STUDY. FOOD AND DRUG  LABORATORIES.  INC. MRID NO  41139  AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON,  DC
                20460.

                US EPA. 1987. HEALTH ASSESSMENT DOCUMENT FOR TERBUFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

TEREPHTHALIC  ACID                                          000100-21-0
         010474  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEREPHTHALIC ACID PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE.  WASHINGTON. DC

TETRACHLOROAZOXYBENZENE                                   021232-47-3
         010064  US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB. TCAOB AND TCHB  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

TETRACHLOROBENZENE.  1.2.4.5-                             000095-94-3
         010286  CHU I. DC VILLENEUVE.  VE VALLI AND VE SECOURS.  1984. TOXICITY OF 1.2.3.4-. 1.2.3.5- AND 1.2.4,5-TETRACHLOROBENZENE IN THE RAT: RESULTS OF
                A 90-DAY FEEDING STUDY. DRUG CHEM TOXICOL.  7:  113-127.

                US EPA. 1985. RfD/RfC WORK GROUP.

TETRACHLOROCYCLOPENTADIENE                               000695- 77-2
         005303  US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES  PREPARED BY  THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY
                RESPONSE. WASHINGTON.  DC.
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                                         REFERENCES FOR  HEAST  TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                             (OTHER THAN CARCINOGENICITY)                                              May 1995



TETRACHLOROETHANE. 1.1.1.2-                              000630-20-6
        010407  NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. CARCINOGENESIS STUDIES OF 1.1.1.2-TETRACHLOROETHANE IN  F344/N RATS AND B6C3F1MICE.  NTP.
                WASHINGTON.  DC.

                US EPA.  1987. RfD/RfC WORK GROUP.

                US EPA.  1993. REVISED AND UPDATED  DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR TETRACHLOROETHANE. 1.1.1.2-.  PREPARED  BY THE
                OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF WATER.
                WASHINGTON.  DC.

TETRACHLOROETHYLENE                                       000127-18-4
        005650  BUBEN. JA AND EJ O'FLAHERTY.  1985. DELINEATION OF THE  ROLE OF METABOLISM IN THE HEPATOXICITY OF  TRICHLOROETHYLENE AND PERCHLOROETHYLENE:
                A DOSE-EFFECT STUDY. TOXICOL APPL  PHARMACOL.  78:  105-122.

                US EPA.  1987. RfD/RfC WORK GROUP.

TETRACHLOROHYDRAZOBENZENE                                071753 -42-9
        010065  US EPA  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB. TCAOB AND TCHB.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.

TETRACHLOROPHENOL. 2.3.4.5-                              004901-51-3
        005324  US EPA  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON
                DC.

TETRACHLOROPHENOL. 2.3.4.6-                              000058-90-2
        005323  US EPA.  1986. 2.3.4.6-TETRACHLOROPHENOL. 90-DAY SUBCHRONIC ORAL TOXICITY STUDY  IN RATS  OFFICE OF SOLID WASTE. WASHINGTON.  DC.

TETRACHLOROPHENOL, 2.3.5.6-                              000935-95-5
        005325  US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON
                DC.

                US EPA.  1987. RfD/RfC WORK GROUP.

TETRACHLOROPROPENE.  1.1.2.3-                            010436-39-2
        010066  US EPA.  1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF  SOLID WASTE. WASHINGTON. DC.



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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER  THAN CARCINOGENICITY)                                              May 1995


TETRACHLOROVINPHOS  / (STIROPHOS)                        000961-11-5
        010067  SHELL CHEMICAL COMPANY. 1968.  CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY   ACCESSION NO 115684

                US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.

                US EPA. 1986.  RfD/RfC WORK GROUP.

TETRAETHYL DITHIOPYROPHOSPHATE                          003689-24-5
        010287  KIMMERLE G AND OR KLIMMER. 1974.  ACUTE AND SUBCHRONIC TOXICITY  OF  SULFOTEP  ARCH TOXICOL  33(1): 1-16.

                US EPA. 1988.  RfD/RfC WORK GROUP.

THALLIC  OXIDE                                              001314-32-5
        010956  US EPA. 1993.  RfD/RfC WORK GROUP.

THALLIUM (I) ACETATE                                     000563-68-8
        005664  US EPA. 1986.  SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT  ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH OFFICE OF SOLID  WASTE AND  EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA. 1988.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND  COMPOUNDS  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1988.  RfD/RfC WORK GROUP.

THALLIUM (I) CARBONATE                                    006533-73-9
        005668  US EPA. 1986.  SUBCHRONIC  (90 DAY) TOXICITY  OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT  ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA 1988  HEALTH AND ENVIRONMENTAL  EFFECTS  DOCUMENT FOR THALLIUM AND  COMPOUNDS  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1988.  RfD/RfC WORK GROUP.
                                                                                                                                                Rl-91

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                                           REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN  CARCINOGENICITY)
                                                                                                                      Hay 1995
THALLIUM (I)  CHLORIDE                                     007791-12-0
         005672   US EPA.  1986. SUBCHRONIC (90 DAY)  TOXICITY OF THALLIUM (I)  SULFATE  (CA NO  7446-18-6) IN SPRAGUE-DAWLEY RATS
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.
                                                                                                   FINAL REPORT.  ENVIRONMENTAL
                 US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1988. RfD/RfC WORK GROUP.

THALLIUM (I)  NITRATE                                      010102-45-1
         005676   US EPA.  1986. SUBCHRONIC (90 DAY)  TOXICITY OF THALLIUM (I) SULFATE  (CA NO  7446-18-6) IN SPRAGUE-DAWLEY RATS  FINAL REPORT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1988. RfD/RfC WORK GROUP.

THALLIUM (I)  SULFATE                                      007446-18-6
         005682   US EPA.  1986. SUBCHRONIC (90 DAY)  TOXICITY OF THALLIUM (I) SULFATE  (CA NO  7446-18-6) IN SPRAGUE-DAWLEY RATS  FINAL REPORT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA.  1988. RfD/RfC WORK GROUP.

THALLIUM (IN  SOLUBLE SALTS)
         010458   US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.
THALLIUM  SELENITE
        010957  US EPA.
                                      012039-52-0
1993.  RfD/RfC WORK GROUP.
                                                                                                                                                 Rl-92

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995


THIOCYANOMETHYLTHIOBENZOTHIAZOLE.  2-(                 021564-17-0
        010068  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR TCMTB. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE.  WASHINGTON. DC.

THIOFANOX                                                   013196-18-4
        010069  US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THIOFANOX. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

THIRAM                                                       000137-26-8
        010459  E.I. DU PONT DE NEMOURS AND COMPANY, INC. 1954. MRID NO.  0045162. AVAILABLE FROM EPA.  WRITE  TO FOI.  EPA. WASHINGTON. DC 20460.

                US EPA. 1987. RfD/RfC WORK GROUP.

        010070  HORNSHAW TC. RJ AULERICH AND  RK RINGER. 1987. TOXICITY  OF THIRAM  (TETRAMETHYLTHINORAM DISULFIDE) TO  MINK AND EUROPEAN FERRETS.  BULL
                ENVIRON CONTAM TOXICOL. 38(4): 618-626.

                US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THIRAM. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

TIN AND  COMPOUNDS
        005688  NTP (NATIONAL TOXICOLOGY PROGRAM).  1982. CARCINOGENESIS BIOASSAY OF STANNOUS CHLORIDE (CAS NO 7772-99-8)  IN F344/N RATS AND B6C3F1/N MICE
                (FEED STUDY). NCI/NTP TECH REP SER  NO 231. ALSO PUBL AS DHHS  (NIH) PUBL  ISS NIH 82-1787 AND NTIS  PB  82-242-553.

                US EPA. 1986. SUBCHRONIC (90  DAY) TOXICITY OF THALLIUM  (I) SULFATE (CAS  NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS.  FINAL REPORT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI.  OH. OFFICE OF  SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON. DC.

                US EPA. 1987. HEALTH EFFECTS  ASSESSMENT FOR TIN. ENVIRONMENTAL  CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI, OH.  OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE. WASHINGTON. DC.
                                                                                                                                                  Rl-93

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995


TOLUENE                                                      000108-88-3
        010469  NTP  (NATIONAL TOXICOLOGY PROGRAM). 1989  TOXICOLOGY AND CARCINOGENESIS STUDIES OF TOLUENE  IN F344 RATS AND B6C3F1 MICE  TECHNICAL REPORT
                SERIES NO 371.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR TOLUENE.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA. 1990. RfD/RfC WORK GROUP.

        010844  FOO  S. J JEYARATHAM AND D KOH.  1990. CHRONIC NEUROBEHAVIORAL EFFECTS OF TOLUENE  BR J IND  MED  47(7). 480-484.

                NTP  (NATIONAL TOXICOLOGY PROGRAM). 1990. TOXICOLOGY AND CARCINOGENESIS STUDIES OF TOLUENE  IN F344/N RATS AND B6C3F1  MICE (INHALATION
                STUDIES). NTP TR 371. 253 P.

                US EPA. 1991. RfD/RfC WORK GROUP.

TOLUENE-2.5-DIAMINE                                       000095-70-5
        010073  NCI  (NATIONAL CANCER INSTITUTE).  1978. BIOASSAY OF TOLUENE-2.5-DIAMINE SULFATE FOR POSSIBLE CARCINOGENICITY  NCI CARCINOGENESIS  TECH REP
                SER  NO 126.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC

TOLUENE-2.6-DIAMINE                                       000823-40-5
        010074  NCI  (NATIONAL CANCER INSTITUTE).  1980. BIOASSAY OF 2.6-TOLUENEDIAMINE DIHYDROCHLORIDE FOR  POSSIBLE CARCINOGENICITY.  NCI  CARCINOGENESIS
                TECH REP SER NO 200.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.

TOLUENEDIAMINE.  2.3-                                       002687-25-4
        010071  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC

TOLUENEDIAMINE.  3.4-                                       000496-72-0
        010072  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC
                                                                                                                                                 Rl-94

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                                          REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN  CARCINOGEN1CITY)                                              Hay  1995


TOLUIDINE. M-                                              000108-44-1
        010075  US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIDINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

TRIALLATE                                                  002303-17-5
        010076  MONSANTO COMPANY.  1979. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY  ACCESSION NO 242057

                US EPA. 1986.  RfD/RfC WORK GROUP.

TRIBROMOBENZENE.  1.2.4-                                  000615-54-3
        010077  CARLSON GP AND RG  TARDIFF. 1977.  EFFECT  OF  1.4-DIBROMODIBENZENE AND  1.2.4-TRIBROMOBENZENE ON XENOBIOTIC METABOLISM.  TOXICOL  APPL
                PHARMACOL. 42: 189-196.

                US EPA. 1984.  HEALFH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE.  WASHINGTON. DC.

                US EPA. 1986.  RfD/RfC WORK GROUP.

TRICHLORO-1.2.2-TRIFLUOROETHANE,  1.1.2-               000076-13-1
        010460  INBUS HR AND C ATKINS. 1972. PHYSICAL EXAMINATION OF WORKERS EXPOSED TO TRICHLOROTRIFLUOROETHANE. ARCH ENVIRON HEALTH  24(4):  257-261.

        010376  TRACHIMOWICZ HJ. GM RUSCH. T CHIU.  ET AL. 1988. CHRONIC INHALATION TOXICITY/CARCINOGENICITY STUDY  IN RATS EXPOSED TO FLUOROCARBON 113
                (FC-113).  FUND APPL TOXICOL. 11(1).  68-75.

                US EPA. 1990.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.1.2-TRICHLORO-1.2,2-TRIFLUOROETHANE. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE. WASHINGTON. DC.

TRICHLORO-2'-HYDROXYDIPHENYLETHER. 2.2.4'-            003380-34-5
        005492  LYMAN. FL AND  T FURIA. 1969. TOXICOLOGY  OF  2.4.4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER  IND MED.  38: 45-52.

                US EPA. 1987  HEALTH EFFECTS AND ENVIRONMENTAL DOCUMENT FOR HALOETHERS. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH.
                OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.
                                                                                                                                                Rl-95

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                                        REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                           (OTHER THAN CARCINOGEN 1C ITY)
                                                                                                                                      May 1995
 TRICHLOROBENZENE.  1.2.4-                                000120-82-1
         010506  ROBINSON. KS.  RJ KAVLOCK.  N CHERNOFF AND E GRAY.  1981. MULTIGENERATION STUDY OF TRICHLOROBENZENE  IN RATS.  J. TOXICOL.  ENVIRON. HEALTH. 8:
                             5S5
        010958
                                                                       ^
                                                                               °F
                                                                                                       IN THE RAT. RABBIT AND BEAGLE DOG.  DRUG


                                                                                             M°NKEYS T° 1.2.4-TRICHLOROBENZENE  ARCHIVES OF


                                       mi)VEiiErS'  VE VALLL 1988' TRICHLOROBENZENES: RESULTS * A THIRTEEN WEEK FEEDING STUDY IN THE RAT.  DRUG

               US EPA.  1993. RfD/RfC WORK GROUP.

TRICHLOROCYCLOPENTADIENE                               077323-84-3
        005304  US EPA.  1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES  PREPARED RY THF

                                       E"VIMME"TAL CRITERIA A"° ASS£SS"ENT OFFICE-        ™           "
TRICHLORO£1HAN£. 1.1.2-

        0057(12
                                     - *"
                                                          000079-00-5
                                                                       1965  TOXICOLOGY OF '-1-2 T«1CHLO«OETH«IE  M THE HOUSE. MUG CHE« TOXICOL.

               US EPA. 1990.  RfD/RfC WORK GROUP.
                                                                                                   STa™S * "IC£ ExroSED T0
                                                                                                                                       Rl-96

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                                         REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN  CARCINOGEN1CITY)                                              May 1995


TRICHLOROFLUOROMETHANE                                   000075-69-4
        005502  NCI (NATIONAL CANCER INSTITUTE).  1978. BIOASSAY OF TRICHLOROFLUOROMETHANE  FOR POSSIBLE CARCINOGEN1CITY. NCI CARCINOGENESIS TECH REP  SER
                NO 106. ALSO PUBL AS DHEW (NIH) 78-1356.

                US EPA  1987  HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES.  PREPARED  BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC

                US EPA. 1985. RfD/RfC WORK GROUP.

        005500  NCI (NATIONAL CANCER INSTITUTE).  1978. BIOASSAY OF TRICHLOROFLUOROMETHANE  FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP  SER
                NO 106. ALSO PUBL AS DHEW (NIH) 78-1356.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH.
                OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

TRICHLOROPHENOL. 2.3.4-                                   015950-66-0
        005330  US EPA  1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT  FOR CHLORINATED PHENOLS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

TRICHLOROPHENOL. 2.3.5-                                   000933-78-8
        005331  US EPA  1987  HEALTH AND ENVIRONMENTAL  EFFECTS  DOCUMENT  FOR CHLORINATED PHENOLS   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

TRICHLOROPHENOL. 2.3.6-                                   000933-75-5
        005332  US EPA  1987  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT  FOR CHLORINATED PHENOLS   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.
                                                                                                                                                 Rl-97

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                                          REFERENCES FOR  HEAST TABLE 1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGEN1CITY)                                              May 1995


TRICHLOROPHENOL.  2.4.5-                                   000095-95-4
         005329  MCCOLLISTER. DO. DT LOCKWOOD AND VK ROME.  1961  TOXICOLOGIC INFORMATION ON 2,4.5-TRICHLOROPHENOL.  TOXICOL APPL PHARMACOL. 3.  63-70.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 2.4.5-TRICHLOROPHENOL.  PREPARED  BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR CHLORINATED PHENOLS  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

                US EPA. 1985. RfO/RfC WORK GROUP.

         010919  US EPA. 1991. RfD/RfC WORK GROUP.

TRICHLOROPHENOL.  2.4.6-                                   000088-06-2
         010461  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR CHLORINATED PHENOLS  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

                US EPA. 1991. RfD/RfC WORK GROUP.

TRICHLOROPHENOL.  3.4.5-                                   000609-19-8
         005333  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR CHLORINATED PHENOLS  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENT
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

TRICHLOROPHENOXY) PROPIONIC ACID.  2(2.4.5-             000093-72-1
         010284  GEHRING PJ AND JE BETSO.  1978.  PHENOXY ACIDS: EFFECTS AND FATE IN MAMMALS  IN: CHLORINATED PHENOXY  ACIDS AND THEIR DIOXINS VOL 27  C
                RAMEL ED.  ECOL BULL.  STOCKHOLM. P.  122-133.

                MULLISON WR.  1966.  SOME  TOXICOLOGICAL ASPECTS OF SILVEX.  IN:  PROC 19TH ANN MEET SOUTHERN WEED CONFERENCE. JACKSONVILLE.  FL. P. 420-435.

                US EPA. 1988.  RfD/RfC WORK GROUP.
                                                                                                                                               Rl-98

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                                          REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN  CARCINOGEN1CITY)                                              May 1995


TRICHLOROPHENOXYACETIC ACID. 2.4.5-                    000093-76-5
        010178  KOCIBA. RS.  OG KEYES. RW LISOWE.  ET AL.  1979. RESULTS OF 2-YEAR CHRONIC TOXICITY AND ONCOGENICITY  STUDY OF RATS INGESTING DIETS
                CONTAINING 2.4.5-T.  FOOD COSMET TOXICOL.  17: 205 -222.

                SMITH FA. FJ MURRAY. JA JOHN. ET AL. 1981. THREE-GENERATION REPRODUCTION  STUDY OF RATS INGESTING 2,4.5-TRICHLOROPHENOXYACETIC ACID  IN THE
                DIET. TOXICO RES LAB.. DOW CHEMICAL. MIDLAND. MI

                US EPA  1989  HEALTH EFFECTS ASSESSMENT FOR  2 4 5-TRICHLOROPHENOXY ACETIC ACID  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
                DC.

                US EPA. 1988. RfD/RfC WORK GROUP.

        010179  GEHRING. PJ. AND JE  BETSO. 1978. PHENOXY ACIDS. EFFECTS AND FATE IN MAMMALS  ECO  BULL  27  122-123

                US EPA  1989  HEALTH EFFECTS ASSESSMENT FOR  2.4.5-TRICHLOROPHENOXY ACETIC ACID  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
                DC.

TRICHLOROPROPANE.  1.1.1-                                 007789-89-1
        005705  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT  FOR TRICHLOROPROPANES   ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.
                OH. OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE. WASHINGTON.  DC.

TRICHLOROPROPANE.  1.1.2-                                 000598-77-6
        005708  VILLANEUVE. DC. I CHU.  VE  SECOURS.  MG COTIE. GL PLAA  AND VE VALLI. 1985.  RESULTS  OF  A 90-DAY TOXICITY STUDY ON 1.2.3- AND
                1.1.2-TRICHLOROPROPANE  ADMINISTERED VIA THE  DRINKING  WATER. SCI TOTAL ENVIRON   47, 421-426

                US EPA.  1987. RfD/RfC WORK GROUP.

TRICHLOROPROPANE.  1.2.2-                                 003175-23-3
        005706  US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES   ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.
                OH. OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.  WASHINGTON.  DC.
                                                                                                                                                 Rl-99

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                                          REFERENCES FOR  HEAST TABLE  1:   SUBCHRONIC  AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              Nay 1995


TRICHLOROPROPANE.  1.2.3-                                  000096-18-4
        005714  NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. FINAL  REPORT 120-DAY TOXICITY GAVAGE  STUDY OF 1 2 3-TRICHLOROPROPANE  IN FISCHER 344 RATS
                PERFORMED BY HAZELTON LABORATORIES.

                US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR TRICHLOROPROPANES.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI
                OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA. 1986.  RfD/RfC WORK GROUP.

TRICHLOROPROPENE.  1.2.3-                                  000096-19-5
        010078  MCKENNA MJ. JF QUAST AND GA STEVENS. 1978.  RESULTS  OF A90-DAY INHALATION TOXICITY STUDY OF 1.2.3-TRICHLOROPROPENE IN LABORATORY ANIMALS
                TOXICOL APPL PHARMACOL.  45: 249.

                US EPA. 1983.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR CHLOROPROPENES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE. WASHINGTON.  DC.

TRICHLOROTOLUENE.  2,3.6-                                  002077-46-5
        005335  CHU I. SY SHEN. DC VILLENEUVE. VE SECOURS AND VE VALLI. 1984. TOXICITY OF TRICHLOROTOLUENE ISOMERS:  A 28-DAY FEEDING STUDY IN THE RAT  J
                ENVIRON SCI HEALTH PART  B PESTIC FOOD CONTAM  AGRIC  WASTES. 19(2): 183-192.

                US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR CHLORINATED TOLUENES. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
                CINCINNATI. OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC

TRICHLOROTOLUENE.  ALPHA.2.6-                             002014-83-7
        005339  CHU I. SY SHEN. DC VILLENEUVE. VE SECOURS AND VE VALLI. 1984. TOXICITY OF TRICHLOROTOLUENE ISOMERS:  A 28-DAY FEEDING STUDY IN THE RAT  J
                ENVIRON SCI HEALTH PART  B PESTIC FOOD CONTAM  AGRIC  WASTES. 19(2): 183-192.

                US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR CHLORINATED TOLUENES. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
                CINCINNATI. OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.
                                                                                                                                               Rl-100

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                                          REFERENCES FOR HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                              May 1995



TRIFLURALIN                                                 001582-09-8
        010080  HOECHST AKTIENGESELLSCHAFT.  1984. CONFIDENTIAL BUSINESS  INFORMATION. UNPUBLISHED STUDY.  MRID NO 00151908. AVAILABLE FROM EPA.  WRITE  TO
                FOI, EPA. WASHINGTON.  DC 20460.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN. PREPARED BY THE  OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE.  WASHINGTON. DC.

                US EPA. 1989. RfO/RfC WORK GROUP.

                US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF  TOXICOLOG1C EFFECTS FOR TRIFLURALIN. PREPARED BY THE OFFICE OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

TRIMETHYLBENZENES
        005727  US EPA. 1987. HEALTH AND ENVIRONMENTAL ASSESSMENT FOR TRIMETHYLBENZENES. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENT ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

TRINITROBENZENE. 1.3.5-                                   000099-35-4
        010081  CODY TE. S WITHERUP. L HASTINGS. K STEMMER AND RT CHUSTION  1981.  1.3-DINITROBENZENE  TOXIC EFFECTS IN VITRO.  J TOXICOL ENVIRON HEALTH.
                7: 829-847.

                US EPA 1989  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3.5-TRINITROBENZENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND  EMERGENCY  RESPONSE.
                WASHINGTON. DC.

                US EPA. 1988. RfD/RfC WORK GROUP.

TRINITROPHENOLS
        010082  US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRINITROPHENOLS   PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE. WASHINGTON.  DC

TRINITROPHENYLMETHYLNITRAMINE                           000479-45-8
        010377  FATI S. E DANIELE.  1965. HISTOPATHOLOGICAL  CHANGES  IN EXPERIMENTAL CHRONIC  TETRYL POISONING   FOLIA MED. 48(4): 260-276.

                US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRINITROPHENYLMETHYLNITRAMINE  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY
                RESPONSE. WASHINGTON. DC.
                                                                                                                                                 Rl-101

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                                           REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC  TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                              May 1995


TRINITROTOLUENE.  2.4.6-                                  000118-96-7
         010416  US 000 (DEPARTMENT OF DEFENSE).  1983. AD-A157-002. DEFENSE TECHNICAL  CENTER. CAMERON STATION. ALEXANDRIA. VA

                 US EPA.  1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2.4.6-TRINITROTOLUENE  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE  WASHINGTON
                 DC.

                 US EPA.  1988. RfD/RfC WORK GROUP.

VANADIUM                                                    007440-62-2
         005739  SCHROEDER.  HA. M MITCHENER AND AP  NASON. 1970. ZIRCONIUM.  NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR.  100:  59-69.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

VANADIUM PENTOXIDE                                        001314-62-1
         005743  STOKINGER.  HE. WD WAGNER.  JT MOUNTAIN ET AL. 1953. UNPUBLISHED  RESULTS. DIV OCCUR HEALTH.  CINCINNATI. OH. CITED IN STOKINGER.  1981.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC

                 US EPA.  1986. RfD/RfC WORK GROUP.

VANADIUM SULFATE                                           036907-42-3
         005747   SCHROEDER. HA. M MITCHENER AND AP  NASON. 1970  ZIRCONIUM.  NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR  100:  59-69.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI.  OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

VERNAM  / (VERNOLATE)                                      001929-77-7
         010083   STAUFFER CHEMICAL COMPANY.  1983. CONFIDENTIAL BUSINESS  INFORMATION. UNPUBLISHED STUDY  ACCESSION  NOS 249703-249704.

                 US EPA. 1983.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR VERNOLATE  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.

                 US EPA. 1986.  RfD/RfC WORK GROUP.
                                                                                                                                                Rl-102

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                                          REFERENCES FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER  THAN  CARCINOGENICITY)                                               May 1995



VINYL ACETATE                                               000108-05-4
        010417  SHAW DC. 1988. VINYL ACETATE:  104-WEEK ORAL (DRINKING WATER) COMBINED CHRONIC TOXICITY AND CARCINOGENICITY STUDY IN THE RAT  FOLLOWING IN
                VITRO EXPOSURE. VOLUME I.  HAZELETON LABORATORIES. UK. REPORT NO.  5531-5/16   EPA DOC  NO  86-0000265. FICHE NO OTS0514156.

                US EPA  1989  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR VINYL ACETATE   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON  DC.

        010418  OWEN  PE  1988. VINYL ACETATE-  104 WEEK INHALATION COMBINED CHRONIC TOXICITY AND  CARCINOGENICITY STUDY IN THE RAT AND MOUSE  REPORT
                PREPARED BY HAZELTON LABORATORIES EUROPE. LTD.. HARROGATE. ENGLAND FOR THE  SOCIETY OF THE PLASTICS  INDUSTRY. INC..  NEW YORK. REPORT  NO.
                5547-51/15. NOVEMBER. 1988.

                BEEMS.  RB. 1988. REPORT NO V88-133: HISTOPATHOLOGY OF THE RESPIRATORY TRACT OF MICE USED  IN A 104-WEEK INHALATION STUDY (OWEN. 1988) WITH
                VINYL ACETATE. (TNO-CIVO INSTITUTES. APRIL. 1988).

                DREEF.  VAN DER MEULEN. HC. 1988. REPORT NO  V88. 033/270836: HISTOPATHOLOGY OF THE RESPIRATORY TRACT OF RATS USED IN A 104 WEEK
                INHALATION STUDY (OWEN. 1988)  WITH VINYL ACETATE: REVISED VERSION (TNO-CIVO INSTITUTES. OCTOBER. 1988).

                US EPA. 1990. RfD/RfC WORK GROUP.

VINYL-1-CYCLOHEXENE. 4-                                    000100-40-3
        010084  US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR 4-VINYL-1-CYCLOHEXENE   PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

WARFARIN                                                     000081-81-2
        010409  HUFF. BB. ED. 1985. PHYSICIANS DESK REFERENCE,  39TH  ED. MEDICAL ECONOMICS CO .  INC..  ORADELL. NJ.

                US EPA. 1986. RfD/RfC WORK GROUP.

XYLENE.  M-                                                   000108-38-3
        005755  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1986. NTP  TECHNICAL REPORT ON THE TOXICOLOGY  AND  CARCINOGENESIS  OF  XYLENES  (MIXED)  (60 2IM-XYLENE.
                13.61 P-XYLENE. 17.0% ETHYLBENZENE AND 9.IX 0-XYLENE) (CAS  NO. 1330-20-7)  IN F344/N  RATS  AND B6C3F1 MICE  (GAVAGE STUDIES)  US DHHS.  PHS.
                NIH. NTP. RESEARCH TRIANGLE PARK. NC. NTP TR  327. NIH PUBL  NO 86-2583.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  XYLENES  (0-. M-. P-)   ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.
                CINCINNATI. OH. OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON. DC

        010920  US EPA. 1991. RfD/RfC WORK GROUP.
                                                                                                                                                  Rl-103

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                                           REFERENCES  FOR HEAST TABLE  1:   SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER THAN CARCINOGENICITY)                                               May 1995


 XYLENE.  MIXTURE                                            001330-20-7
         010872  NTP (NATIONAL TOXICOLOGY PROGRAM).  1986. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS OF XYLENES  (MIXED) (60 2SM-XYLENE
                 13.6%  P-XYLENE. 17.OX ETHYLBENZENE  AND 9.IX 0-XYLENE) (CAS NO.  1330-20-7)  IN F344/N RATS AND B6C3F1 MICE  (GAVAGE STUDIES)  US DHHS  PHS
                 NIH. NTP. RESEARCH TRIANGLE PARK. NC. NTP TR 327. NIH PUBL NO 86-2583.

                 US  EPA.  1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR XYLENES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH. FOR THE OFFICE  OF  EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON. DC.

                 US  EPA.  1987. RfD WORK GROUP.

         010921   US  EPA.  1991. RfD/RfC WORK GROUP.

 XYLENE.  0-                                                  000095-47-6
         005751   NTP (NATIONAL TOXICOLOGY PROGRAM).  1986. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS OF XYLENES  (MIXED) (60 2% M-XYLENE
                 13.61  P-XYLENE. 17.OX ETHYLBENZENE  AND 9.1X 0-XYLENE)  (CAS NO.  1330-20-7)  IN F344/N RATS AND B6C3F1 MICE  (GAVAGE STUDIES)  US DHHS  PHS
                 NIH. NTP. RESEARCH TRIANGLE PARK. NC. NTP TR 327. NIH PUBL NO 86-2583.

                 US  EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR XYLENES (0-. M-. P-)  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
                 CINCINNATI. OH. OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

        010922   US  EPA.  1991. RfD/RfC WORK GROUP.

XYLENE.  P-                                                  000106-42-3
        010923   US EPA.  1991. RfD/RfC WORK GROUP.

ZINC (METALLIC)                                            007440-66-6
        010937   YADRICK. MF. MA KENNEY AND EA WINTERFELDT.  1989.  IRON.  COPPER AND ZINC STATUS.  RESPONSE  TO SUPPLEMENTATION WITH ZINC OR ZINC AND IRON IN
                ADULT FEMALES.  AM J CLIN NUTR. 49:  145-150.

                US EPA. 1991.  RfD/RfC WORK GROUP.

ZINC CYANIDE                                                000557-21-1
        010289  HOWARD JW AND RF HANZAL.  1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM.  3:  325-329

                PHILBRICK DJ.  JB HOPKINS.  DC HILL. JC ALEXANDER AND RG THOMSON.  1979.  EFFECTS OF  PROLONGED CYANIDE AND THIOCYANATE  FEEDING  IN  RATS J
                TOXICOL ENVIRON HEALTH.  5:  579-592.

                US EPA. 1985.  RfD/RfC WORK GROUP.
                                                                                                                                                Rl-104

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                                         REFERENCES FOR  HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                             (OTHER THAN CARCINOGENICITY)                                              May  1995


ZINC PHOSPHIDE                                             001314-84-7
        010290  BAI KM.  MK KRISHNAKUMARI.  JP  RAMESH. T SHIVANANDAPPA AND SK MAJUNDER.  1980  SHORT-TERM TOXICITY  STUDY OF ZINC PHOSPHIDE IN ALBINO RATS.
                INDIAN J EXPTL BIOL. 18: 854-857.

                US EPA.  1986. RfD/RfC WORK GROUP.

ZINEB                                                       012122-67-7
        010085  BLACKWELL-SMITH RJ JR. JK FINNEGAN. PS LARSON.  ET AL.  1953. TOXICOLOGIC STUDIES ON ZINC AND DISODIUM ETHYLENE BISDITHIOCARBAMATES  J
                PHARMACOL EXP THER. 109: 159-166.

                US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ZINEB.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.

                US EPA.  1986. RfD/RfC WORK GROUP.
                                                                                                                                              Rl-105

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                                       HEAST TABLE 2:
                           ALTERNATE METHODS - SUBCHRONIC  AND  CHRONIC TOXICITY
                                (OTHER THAN CARCINOGENICITY)
                                                                                                                                               May 1995
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT  LENGTH
              TARGET
                CRITICAL EFFECT
ACETONE  CYANOHYDRIN
     NOEL  4.0 MG/KG/DAY
              INHALATION:
              INTERMITTENT
       000075-86-5
 RAT
14 WEEKS
CENTRAL NERVOUS
SYSTEM
EFFECTS
                                         Subchronic
                                 [RfC]      [RfD]
                               (mg/cu m) (mg/ko/dav)
                                  UF         UF
1E-1
100
                             Chronic
                        [RfC]     [RfD]
                      (mg/cu m) (mq/kq/dav)
                         UF         UF
                                                                                                           REFERENCE
1E-2
1000
010432
            SUBCHRONIC [RfC] COMMENT:   4E-2 MG/KG/DAY (SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST)  AN ERROR IN THE UNCERTAINTY  FACTOR THAT WAS
                               REPORTED IN HEED (1988)  WAS CORRECTED.
            CHRONIC [RfC] COMMENT:   4E-2 MG/KG/DAY (SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST)
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE  INTERIM
                               INHALATION METHODOLOGY USED BY  THE  RfD/RfC WORK GROUP  ALSO SEE TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
ACETONITRILE
     NOAEL 100 PPM
              INHALATION:
              INTERMITTENT
       000075-05-8
 MOUSE
92 DAYS
LIVER
INCREASED RELATIVE WEIGHT
5E-1
300
5E-2
3000
005208
            SUBCHRONIC [RfC] COMMENT:   1E-1 MG/KG/DAY (SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST)
            CHRONIC [RfC] COMMENT:   1E-2 MG/KG/DAY. (SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST)  UNDER REVIEW. CURRENT NUMBER SUBJECT  TO  CHANGE.
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE  INTERIM
                                INHALATION METHODOLOGY USED BY THE  RfD/RfC WORK GROUP.  ALSO SEE TABLE 1-  SUBCHRONIC AND  CHRONIC TOXICITY.
BARIUM
     NOEL  0.8 MG/CU M
              INHALATION:
              INTERMITTENT
       007440-39-3
 RAT
4 MONTHS
FETUS
FETOTOXICITY
5E-3
100
5E-4
1000
005249
            SUBCHRONIC [RfC] COMMENT:   1E-3 MG/KG/DAY (SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST)  BASED ON A REPRODUCTION STUDY.
            CHRONIC [RfC] COMMENT:   1E-4 MG/KG/DAY (SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST). BASED ON A REPRODUCTION STUDY.
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE  INTERIM
                                INHALATION METHODOLOGY USED BY  THE  RfD/RfC WORK GROUP.   ALSO SEE TABLE 1.  SUBCHRONIC AND  CHRONIC TOXICITY
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                     2-1

-------
                                       HEAST TABLE 2:
                                             ALTERNATE METHODS  -  SUBCHRONIC AND CHRONIC TOXICITY
                                                  (OTHER  THAN  CARCINOGEN1CITY)
                                                                                                                                              Hay 19%
CHEMICAL
LEVEL
ROUTE
                           SPECIES
                      EXPERIMENT LENGTH
TARGET
                                               CRITICAL  EFFECT
          Subchromc
  [RfC]      [RfO]
(mq/cu m)  (mg/ka/dav)
   UF         UF
      Chronic
  [RfC]      [RfD]
(ma/cu m)  (mg/ka/dav)
   UF        UF
                                                                                                                            REFERENCE
CHLORO-1.3-BUTADIENE /
     NOAEL 10 PPM
              INHALATION:
              INTERMITTENT
               (CHLOROPRENE)
                   RAT
                  2 YEARS
                                            HAIR
                                            WHOLE BODY
           000126-99-8

               ALOPECIA
               DECREASED WEIGHT GAIN
                                                                                          2E-2
                                                                                          100
                                 2E-2
                                 100
                     005878
            SUBCHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION ASSUMING AN  INHALATION ABSORPTION FACTOR OF  0.5.
            CHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE  EXTRAPOLATION ASSUMING AN INHALATION ABSORPTION FACTOR OF 0.5.
            GENERAL COMMENT:  SEE ALSO HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLOROBENZENE
     LOAEL 75 PPM
              INHALATION:
              INTERMITTENT
                          000108-90-7
                   RAT
                  120 DAYS
                                            LIVER
                                            KIDNEY
               EFFECTS
               EFFECTS
                                                                                                     2E-2
                                                                                                     10000
                                            005353
            CHRONIC [RfC] COMMENT:   5E-3 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS  ON HEAST). UNDER REVIEW.  CURRENT  NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:   THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE  DERIVED FROM METHODOLOGY THAT IS  NOT CURRENT WITH THE INTERIM
                                INHALATION METHODOLOGY  USED BY THE RfD/RfC WORK  GROUP.  ALSO SEE TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY.
CYCLOPENTADIENE
     NOEL  87.3 MG/KG/DAY
             INHALATION:
             INTERMITTENT
                         000542-92-7
                   RAT
                  194 DAYS
                                            LIVER
                                            KIDNEY
               LESIONS
               LESIONS
 3E+0
 100
                                                                                                                          005401
            SUBCHRONIC [RfC]  COMMENT:  9E-1 MG/KG/DAY  (SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST).
            GENERAL COMMENT:   THE  SUBCHRONIC INHALATION [RfC] VALUE WAS DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM INHALATION
                               METHODOLOGY USED BY THE RfD/RfC WORK GROUP.
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                     2-2

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                                       HEAST TABLE 2:
CHEH1CAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
                           ALTERNATE METHODS  -  SUBCHRONIC AND CHRONIC TOXICITY
                               (OTHER THAN  CARCINOGEN1CITY)
                                                                                                                                              Hay 1995
               CRITICAL EFFECT
                                         Subchronic
                                 [RfC]      [RfD]
                               (mg/cu m)  (mq/kg/day)
                                  UF         UF
                            Chronic
                        [RfC]      [RfD]
                      (niq/cu m)  (ma/ko/dav)
                         UF         UF
                                                                                                          REFERENCE
DICHLOROBENZENE. 1.2-
     NOEL  49 PPM               RAT
              INHALATION:        UP TO 7
              INTERMITTENT      MONTHS
       000095-50-1
             WHOLE BODY
                DECREASED WEIGHT GAIN
                                2E+0
                                100
                     2E-1
                     1000
                     005412
            CHRONIC [RfC] COMMENT:  4E-2 MG/KG/DAY  (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
            GENERAL COMMENT:   THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM  METHODOLOGY THAT IS NOT CURRENT WITH THE  INTERIM
                               INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.   ALSO  SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
DICHLORODIFLUOROMETHANE
     LOAEL 482.3  MG/KG/DAY
             INHALATION:
             INTERMITTENT
       000075-71-8
 GUINEA PIG
6 WEEKS       LIVER
                LESIONS
                                2E+0
                                1000
                     2E-1
                     10000
                     005497
            SUBCHRONIC [RfC] COMMENT:  5E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
            CHRONIC [RfC] COMMENT:   5E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE  INTERIM
                                INHALATION METHODOLOGY  USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
DICHLOROETHANE. 1.1-
     NOEL  138 MG/KG/DAY
              INHALATION:
              INTERMITTENT
        000075-34-3
 CAT
13 WEEKS
KIDNEY
DAMAGE
5E+0
100
5E-1
1000
005789
            SUBCHRONIC [RfC] COMMENT:   1E+0 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
            CHRONIC [RfC] COMMENT:   1E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT  IS NOT CURRENT WITH THE INTERIM
                                INHALATION METHODOLOGY  USED BY THE RfD/RfC WORK GROUP  ALSO SEE  HEAST TABLE 1: CHRONIC AND SUBCHRONIC TOXICITY AND
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION.  RISK  INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                    2-3

-------
                                       HEAST TABLE 2:
CHEMICAL    DQSi           SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
              TARGET
                           ALTERNATE METHODS  - SUBCHRONIC AND CHRONIC TOXICITY
                                (OTHER THAN CARCINOGENICITY)
                                                                                                                                               May 1995
               CRITICAL EFFECT
                                         Subchronic
                                 [RfC]      [RfD]
                               (mg/cu m)  (mg/ka/dav)
                                  UF         UF
                             Chronic
                        [RfC]     [RfD]
                      (mq/cu m) (mg/kg/day)
                         UF         UF
                                                                                                           REFERENCE
DICYCLOPENTADIENE
     LOAEL 1 PPM
             INHALATION:
             INTERMITTENT
        000077-73-6
 RAT
90 DAYS
LIVER
DYSFUNCTION
2E-3
1000
2E-4
10000
005424
            SUBCHRONIC [RfC] COMMENT:   6E-4 MG/KG/DAY (SEE APPENDIX  A-II. DOSE CONVERSIONS ON HEAST).
            CHRONIC [RfC] COMMENT:   6E-5 MG/KG/DAY (SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST).
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION  [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT  IS  NOT CURRENT WITH THE INTERIM
                                INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.   ALSO SEE  TABLE  1. SUBCHRONIC AND CHRONIC TOXICITY
ETHOXYETHANOL  ACETATE.  2-        000111-15-9
     NOEL  30.1 MG/KG/DAY        RAT
             INHALATION:       DAY 6-18  OF   FETUS
             INTERMITTENT      GESTATION
                              DECREASED OSSIFICATION
                                                           3E-1
                                                           100
                                                                 3E-1
                                                                 100
                                           005952
            SUBCHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION. THE SUBCHRONIC ORAL [RfD]WAS BASED ON A REPRODUCTION STUDY WITH
                                EXPOSURES DURING DAYS 6-18 OF  GESTATION.
            CHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE  EXTRAPOLATION. THE CHRONIC ORAL [RfD] WAS BASED ON A REPRODUCTION STUDY WITH EXPOSURES
                                DURING DAYS 6-18 OF GESTATION.
            GENERAL COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL  [RfD] VALUES. ALSO SEE
                                TABLE
                                1: SUBCHRONIC AND CHRONIC TOXICITY  VALUES.
FURFURAL
     NOAEL  20  PPM
              INHALATION:
              INTERMITTENT
        000098-01-1
 HAMSTER
13 WEEKS
NASAL CAVITY
OLFACTORY DEGENERATION
5E-1
100
5E-2
1000
005465
            SUBCHRONIC [RfC] COMMENT:   1E-1 MG/KG/DAY (SEE APPENDIX  A-ll. DOSE CONVERSIONS ON HEAST)
            CHRONIC [RfC] COMMENT:   1E-2 MG/KG/DAY (SEE APPENDIX  A-ll.  DOSE CONVERSIONS ON HEAST)
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION  [RfC] VALUES WERE DERIVED FROM METHODOLOGY  THAT  IS NOT CURRENT WITH THE INTERIM
                                INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP  ALSO SEE  TABLE  1  SUBCHRONIC AND CHRONIC TOXICITY
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK  INFORMATION HOTLINE- (513) 569-7254
                                                                                                                     2-4

-------
                                       HEAST TABLE 2:   ALTERNATE METHODS  -  SUBCHRONIC AND CHRONIC TOXICITY
                                                               (OTHER  THAN  CARCINOGEN1CITY)
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT  LENGTH
              TARGET
                                                                                                               May 1995
                      CRITICAL EFFECT
                                         Subchronic           Chronic
                                 [RfC]      [RfD]        [RfC]     [RfD]      REFERENCE
                               (mg/cu m)  (ma/ka/dav)   (mg/cu m)  (ma/kq/dav)
                                  UF          UF           UF        UF
METHACRYLONITRILE
     NOEL  3.2 PPM
              INHALATION:
              INTERMITTENT
 DOG
90 DAYS
000126-98-7

      LIVER
      LIVER
INCREASED  SCOT
INCREASED  SGPT
7E-3
300
7E-4
3000
005811
            SUBCHRONIC [RfC] COMMENT:   2E-3 MG/KG/DAY (SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST)  THESE  VALUES DIFFER FROM THOSE IN THE 1987
                               HEED.
            CHRONIC [RfC] COMMENT:   2E-4 MG/KG/OAY (SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST)  THESE VALUES DIFFER FROM THOSE IN THE 1987
                               HEED.
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT  IS NOT CURRENT WITH THE INTERIM
                               INHALATION METHODOLOGY USED BY THE  RfD/RfC WORK GROUP  ALSO SEE  TABLE  1.  SUBCHRONIC AND CHRONIC TOXICITY.
METHOXYETHANOL ACETATE.  2-       000110-49-6
     NOAEL 10 PPM               RABBIT
              INHALATION:       13 WEEKS      TESTIS
              INTERMITTENT
                              DEGENERATION
                                                                 2E-2
                                                                 100
                                                                2E-3
                                                                1000
                                           010001
            SUBCHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION  USING AN ABSORPTION FACTOR OF 0.5.  CALCULATED FROM DATA OBTAINED WITH
                               METHOXYETHANOL CONVERTED BY  MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118  13/76.09)
            CHRONIC [RfD] COMMENT:   BASED  ON ROUTE TO ROUTE EXTRAPOLATION  USING AN ABSORPTION FACTOR OF 0 5.  CALCULATED FROM DATA OBTAINED WITH
                               METHOXYETHANOL CONVERTED BY  MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118  13/76.09).
            GENERAL COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR  THE  ORAL  [RfD] VALUES.
METHOXYETHANOL. 2-
     NOAEL 31  MG/CU M
              INHALATION:
              INTERMITTENT
        000109-86-4
 RABBIT
13 WEEKS
      TESTICLE
EFFECTS
           1E-2
           100
           1E-3       010910
           1000
            SUBCHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            CHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            GENERAL COMMENT:  ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
IRIS.  EPA'S INTEGRATED RISK  INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION.  RISK INFORMATION HOTLINE. (513) 569-7254.
                                                                                                                     2-5

-------
                                       HEAST TABLE 2:
                           ALTERNATE  METHODS -  SUBCHRONIC  AND CHRONIC TOXICITY
                               (OTHER THAN CARCINOGENICITY)
                                                                                                                                             Hay 1995
CHEMICAL    DQSE          SPECIES
LEVEL       ROUTE     EXPERIMENT LENGTH
              TARGET
                     CRITICAL EFFECT
                                        Subchronic
                                [RfC]      [RfD]
                              (mq/cu m) {ma/kg/day)
                                 UF         UF
                            Chronic
                        [RfC]      [RfO]
                      (IHQ/CU m)  (mg/kg/dav)
                        UF         UF
                                                                                                                                         REFERENCE
METHYL ACRYLATE
     NOEL   15 PPM
             INHALATION:
             INTERMITTENT
       000096-33-3
 RAT
2 YEARS
                      NONE OBSERVED
                                          3E-2
                                          100
                                3E-2
                                100
                                                                                                 010003
            SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            CHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE  EXTRAPOLATION.
            GENERAL COMMENT-  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL  [RfD] VALUES.
METHYL  ISOBUTYL KETONE
     NOEL  50 PPM
              INHALATION:
              INTERMITTENT
 RAT
90 DAYS
000108-10-1

      LIVER
      KIDNEY
INCREASED WEIGHT
EFFECTS
8E-1
100
8E-2
1000
                                                                          005562
            SUBCHRONIC [RfC] COMMENT:   2E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSION ON HEAST).
            CHRONIC [RfC] COMMENT:   2E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSION ON HEAST).
            GENERAL COMMENT-  THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                                INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO  SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY.
 IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                    2-6

-------
                                        HEAST TABLE  2:
                                                          ALTERNATE METHODS  -  SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGEN1CITY)
                                                                                                                                               Hay 1995
LEVEL
             BQSI          SPECIES
             ROUTE    EXPERIMENT LENGTH
                                             TARGET
                CRITICAL  EFFECT
METHYL STYRENE  (MIXED ISOMERS)   025013-15-4
     LOAEL 5.6 HG/KG/DAY        MOUSE
              INHALATION:       103 WEEKS
              INTERMITTENT
                                            NASAL CAVITY     LESIONS
                                         Subchronic
                                 [RfC]      [RfD]
                               (mg/cu m)  (iiH/kQ/day)
                                  UF         UF
                                                                                                       6E-3
                                                                                                       1000
       Chronic
  [RfC]     [RfD]
(mq/cu m)  (mo/ka/dav)
   UF        UF
                                                                                                                                         REFERENCE
                                                                                 6E-3
                                                                                 1000
                                                                           005567
             SUBCHRONIC  [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0 5.
             CHRONIC  [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0 5
             GENERAL  COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE  ORAL  [RfD] VALUES
     LOAEL 11.2 MG/KG/DAY       MOUSE
              INHALATION:       103 WEEKS
              INTERMITTENT
                                            NASAL CAVITY
                 LESIONS
                                                                                             4E-2
                                                                                             1000
                                                                      4E-2
                                                                      1000
                                                                           005566
             SUBCHRONIC [RfC] COMMENT:   1E-2  MG/KG/DAY (SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST)
             CHRONIC [RfC] COMMENT:   1E-2 MG/KG/DAY (SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST)
             GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT IS  NOT CURRENT WITH THE INTERIM
                                INHALATION METHODOLOGY USED BY THE  RfD/RfC WORK GROUP
METHYL  STYRENE. ALPHA
     NOEL  970 MG/CU  M
              INHALATION:
              INTERMITTENT
                                      000098-83-9
                               RAT
                              197 DAYS
LIVER
KIDNEY
INCREASED WEIGHT
INCREASED WEIGHT
                                                                                                       7E-1
                                                                                                       100
          7E-2
          1000
010016
            SUBCHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION  USING AN ABSORPTION FACTOR OF 0 5
            CHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION  USING AN ABSORPTION FACTOR OF 0 5
            GENERAL COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE  ORAL  [RfD] VALUES
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                   2-7

-------
                                       HEAST TABLE 2:
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
                           ALTERNATE METHODS  -  SUBCHRONIC AND CHRONIC TOXICITY
                                (OTHER  THAN  CARCINOGENICITY)
                     CRITICAL EFFECT
                                         Subchronlc
                                 [RfC]      [RfD]
                               (mg/cu m)  (mq/ka/dav)
                                  UF         UF
                                                                                                                                              Hay 1995
                            Chronic
                        [RfC]      [RfD]
                      (IHQ/CU m)  (ma/kg/dav)
                         UF        UF
                                                                                                          REFERENCE
METHYLENE BROMIDE
     NOAEL 11  MG/KG/DAY
              INHALATION:
              INTERMITTENT
        000074-95-3
 RAT
90 DAYS
      BLOOD
INCREASED  CARBOXYHEMOGLOBIN
           1E-1
           100
           1E-2
           1000
010011
            SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE  EXTRAPOLATION. INCLUDING AN ABSORPTION FACTOR OF 0 5.
            CHRONIC [RfD] COMMENT:   BASED ON ROUTE TO ROUTE  EXTRAPOLATION. INCLUDING AN ABSORPTION FACTOR OF 0.5.
            GENERAL COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE  EXTRAPOLATION FOR THE ORAL [RfD]  VALUES.
NITROBENZENE
     LOAEL 25 MG/CU M
              INHALATION:
              INTERMITTENT
 MOUSE
90 DAYS
000098-95-3

      BLOOD
      ADRENAL
      KIDNEY
      LIVER
HEMATOLOGICAL  EFFECTS
LESIONS
LESIONS
LESIONS
2E-2
1000
2E-3
10000
010518
             INHALATION:
             INTERMITTENT
 RAT
90 DAYS
      BLOOD
      ADRENAL
      KIDNEY
      LIVER
HEMATOLOGICAL  EFFECTS
LESIONS
LESIONS
LESIONS
            SUBCHRONIC [RfC] COMMENT:  6E-3 MG/KG/DAY (SEE  APPENDIX A-II. DOSE CONVERSIONS ON  HEAST)
            CHRONIC [RfC] COMMENT:   6E-4 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED  FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                                INHALATION METHODOLOGY  USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY.


TRICHLOROBENZENE.  1.2.4-          000120-82-1
             GENERAL COMMENT:   INFORMATION REMOVED FROM THIS  TABLE. SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
MS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                    2-8

-------
                                       HEAST TABLE 2:
CHEMICAL     DOSE           SPECIES
LEVEL        ROUTE     EXPERIMENT LENGTH
              TARGET
                           ALTERNATE  METHODS - SUBCHRONIC AND CHRONIC  TOXICITY
                               (OTHER THAN CARCINOGENICITY)
                                                                                                                                            May 1995
                     CRITICAL EFFECT
                                        Subchromc
                                [RfC]      [RfO]
                              (mq/cu m) (mg/kq/day)
                                 UF         UF
       Chronic
   [RfC]     [RfO]      REFERENCE
 (mg/cu m)  (mq/kq/dav)
   UF         UF
TRICHLOROFLUOROMETHANE
     LOAEL 1940 MG/KG/DAY
             INHALATION:
             CONTINUOUS
 DOG
90 DAYS
000075-69-4

      KIDNEY
      LUNG
INCREASED BUN
INFLAMMATION
                                                             7E+0
                                                             1000
7E-1
10000
005501
            SUBCHRONIC [RfC] COMMENT:  2E+0 MG/KG/DAY  (SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST).
            CHRONIC [RfC] COMMENT:  2E-1 MG/KG/DAY  (SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST)
            GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC  INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                               INHALATION METHODOLOGY USED BY THE  RfD/RfC I£BK GROUP  ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY
IRIS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE-  (513) 569-7254.
                                                                                                                   2-9

-------
                             REFERENCES FOR HEAST TABLE 2:   ALTERNATE METHODS  --  SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995

ACETONE  CYANOHYDRIN                                       000075-86-5
        010432  BLANK TL AND DC THAKE. 1984. THREE-MONTH INHALATION TOXICITY OF ACETONE CYANOHYDRIN  IN MALE AND FEMALE SPRAGUE-DAWLEY RATS. MONSANTO
                REPORT NOP. MSL-4423. TSCA 8(D) SUBMISSION 878216397 (OTS 0510325).

                US EPA.  1988.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

ACETONITRILE                                               000075-05-8
        005208  COATE WB. 1983. 90-DAY SUBCHRONIC TOXICITY STUDY OF ACETONITRILE IN B6C3F1 MICE  FINAL REPORT (REVISED).

                US EPA.  1987.  HEALTH EFFECTS ASSESSMENT FOR ACETONITRILE.PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND  REMEDIAL RESPONSE. WASHINGTON.  DC.

BARIUM                                                      007440-39-3
        005249  TARASENKO M. 0 PROMIN AND A SILAYEV.  1977. BARIUM COMPOUNDS AS INDUSTRIAL POISONS (AN EXPERIMENTAL STUDY).  J HYG EPIDEM MICROBIOL
                IMMUNOL. 21: 361.

                US EPA.  1984.  HEALTH EFFECTS ASSESSMENT FOR BARIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL  CRITERIA
                AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC.

CHLORO-1.3-BUTADIENE /  (CHLOROPRENE)                   000126-99-8
        005878  DU PONT DE NEMOURS AND COMPANY. INC.  1985. 2-YEAR  INHALATION CARCINOGENICITY  STUDY OF CHLOROPRENE  IN RATS. El DU PONT DE NEMOURS  AND CO..
                INC.. WILMINGTON.  DE.

                US EPA.  1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-CHLORO-1.3-BUTADIENE   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

CHLOROBENZENE                                              000108-90-7
        005353  DILLEY.  JV. 1977.  TOXIC EVALUATION OF INHALED CHLOROBENZENE. NIOSH. OHEW. CINCINNATI. OH. CONTRACT 210-76-0126. CITED IN US EPA.  1985.

                US EPA.  1989.  UPDATED HEALTH EFFECTS ASSESSMENT  FOR CHLOROBENZENE. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

CYCLOPENTADIENE                                           000542-92-7
        005401  DOW. 1987. UNPUBLISHED DATA. DOW CHEMICAL. USA.  MIDLAND, MI.

                US EPA.  1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE. WASHINGTON. DC.


                                                                                                                                                  R2-1

-------
                             REFERENCES  FOR HEAST TABLE 2:   ALTERNATE METHODS  --  SUBCHRONIC AND CHRONIC TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995


DICHLOROBENZENE.  1.2-                                      000095-50-1
        005412  HOLLINGSWORTH RL.  VK ROME.  F OYEN. TR TORKELSON AND EM ADAMS. 1958.  TOXICITY  OF  0-DICHLOROBENZENE  AM MED ASSOC ARCH  IND HEALTH.  17(1):
                180-187.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DICHLOROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

DICHLORODIFLUOROMETHANE                                   000075-71-8
        005497  PRENDERGAST JA.  RA JONES. LJ JENKINS AND J SIEGAL.  1967. EFFECTS ON EXPERIMENTAL ANIMALS OF LONG-TERM INHALATION OF TRICHLOROETHYLENE.
                CARBON TETRACHLORIDE.  1.1.1-TRICHLOROETHANE.  DICHLORODIFLUOROMETHANE AND 1,1-DICHLOROETHYLENE  TOXICOL APPL PHARMACOL  10:  270-289

                US EPA  1987  HEALTH EFFECTS ASSESSMENT FOR FULLY  HALOGENATED METHANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

DICHLOROETHANE.  1.1-                                       000075-34-3
        005789  HOFMANN HT. H BIRNSTIEL AND P JOBST  1971. ON THE  INHALATION TOXICITY OF 1,1- AND 1.2-OICHLOROETHANE. ARCH TOXIKOL 27.  248-265.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHANE  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

DICYCLOPENTADIENE                                          000077-73-6
        005424  DODD DE.  LC LONGO AND DL EISLER.  1982  DICYCLOPENTADIENE VAPOR NINETY-DAY INHALATION  STUDY ON  RATS AND MICE  BUSHY RUN RESEARCH CENTER.
                EXPORT. PA. TSCA 8E SUBMISSION BY EXXON CHEM AMER  DOC  ID 88-8300464. ODD DOC  ID 8EHQ-0283-0364.MICROFICHE NO  OTS 204864

                US EPA  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CYCLOPENTADIENE AND DICYCLOPENTADIENE  PREPARED BY THE OFFICE OF  HEALTH  AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE.  WASHINGTON.  DC.

ETHOXYETHANOL ACETATE.  2-                                 000111-15-9
        005952  UNION CARBIDE.  1984. A TERATOGENIC EVALUATION OF CELLOSOLVE  ACETATE IN FISHER 344 RATS AND NEW ZEALAND WHITE RABBITS  FOLLOWING  INHALATION
                EXPOSURE.  BUSHY RUN RESEARCH CENTER, EXPORT. PA. OCTOBER 1984  FYI-AX-1184-0360

                US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  2- ETHOXYETHANOL  ESTERS   PREPARED  BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE.  WASHINGTON.  DC.
                                                                                                                                                  R2-2

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                              REFERENCES  FOR HEAST TABLE 2:   ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC  TOXICITY
                                                              (OTHER THAN CARCINOGENICITY)                                               May 1995


FURFURAL                                                    000098-01-1
        005465  FERON VJ. A KRUYSSE AND  HC  DREEF VANDER MEULEN.  1979. REPEATED EXPOSURE TO FURFURAL  VAPOR: 13 WEEK STUDY IN SYRIAN GOLDEN HAMSTERS.
                ZENTRASE. BAKTEVIOL PAVASITEN KD INFECTION SKV  HYG ABT 1 ORIG REIHE B. 168(5-6)   442-451

                US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR  FURFURAL. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.DC.

METHACRYLONITRILE                                          000126-98-7
        005811  POZZANI. UC. CR KINKEAD  AND JM KING. 1968. THE  MAMMALIAN TOXICITY OF METHACRYLONITRILE AM IND HYG ASSOC J. 29(3): 202-210.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR  SELECTED NITRILES,  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

METHOXYETHANOL  ACETATE.  2-                               000110-49-6
        010001  MILLER RR. LL CALHOUN AND BL YANO. 1982.  ETHYLENE  GLYCOL MONOMETHYL ETHER  13-WEEK VAPOR  INHALATION STUDY  IN MALE RABBITS  REPORT
                PREPARED FOR THE CHEMICAL MANUFACTURERS ASSOCIATION. MARCH 25. 1982

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR 2- METHOXYETHANOL ACETATE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

METHOXYETHANOL. 2-                                         000109-86-4
        010910  MILLER RR. LL CALHOUN. BL YANO. 1982. ETHYLENE  GLYCOL MONOETHYL ETHER  13 WEEK VAPOR INHALATION STUDY IN MALE RABBITS. REPORT PREPARED
                FOR THE CMA MARCH 25.  1982.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR 2-METHOXYETHANOL  PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

METHYL ACRYLATE                                            000096-33-3
        010003  KLIMISCH HJ AND W REININGHAUS. 1984. CARCINOGENICITY OF ACRYLATES: LONG-TERM INHALATION STUDIES ON METHYL ACRYLATE (MA) AND N-BUTYL
                ACRYLATE (BA) IN RATS. TOXICOLOGIST. 4(1): 53.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR METHYL ACRYLATE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.
                                                                                                                                                  R2-3

-------
                             REFERENCES FOR  HEAST  TABLE  2:   ALTERNATE METHODS --  SUBCHRONIC AND  CHRONIC TOXICITY
                                                              (OTHER  THAN  CARCINOGENIC ITY)                                               "•> 1995




                             CORP. 1983. NINETY-DAY  INHALATION^^S  AND MICE  SPONSORED BY CMA  US EPA/OTS PUBLIC FILES  0750507469.

                                    FFFFCTS ASSESSMENT FOR METHYL ETHYL KETONE.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                                                                      . OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON.  DC.
                                      INSTITUTE).  1984.  STUDY OF WllON CARCINOGEN 1C ITY  (BIOASSAY) OF VINYL TOLUENE IN B6C3F1 MICE.
                US EPA  1987  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR METHYL STYRENES  PREPARED BY THE OFFICE °F HEALTH AND
                ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY  RESPONSE. WASHINGTON. DC.

        005566  FINAL CHRONIC  REPORT PERFORMED FOR THE NTP UNDER CONTRACT NO N01-ES-38042
                WASHINGTON. DC.

UCTUVI  CTVDFMF   Al PHA                                     000098-83-9
        010016  WOLF MA ™ VK ROWE. DO MCCOLLISTER. ET AL. 1956  TOXICOLOGICAL  STUDIES OF CERTAIN ALKYLATED BENZENES AND BENZENE. ARCH  IND
                HEALTH. 14: 387-398.

                IIS FPA  1987  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR ALPHA-  METHYL STYRENE  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRC^S A^SSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON. DC

UCTUVI cur RDOMTnr                                          000074-95-3
        010011  KEYES  DG   JW HENCK  GC JERSEY  RJ KOCIBA  DJ SCHWETZ AND TD LANDRY.  1982   METHYLENE BROMIDE: A 90-DAY REPEATED INHALATION
                SKIT? STUDY IN RAT! ; i DOGS WITH A  SUBSEQUENT TWO-YEAR HOLDING PERIOD  FOR RATS  TOXICOLOGY RESEARCH LAB.  HEALTH AND
                ENVIRONMENTAL SCIENCES. DOW CHEMICAL CO.. MIDLAND. MI.

                IK FPA 19R7   HFAITH AND ENVIRONMENTAL EFFECTS  PROFILE FOR METHYLENE  BROMIDE   PREPARED  BY THE OFFICE OF HEALTH
                m E™ENTA! ^SSES^MEN! ^EN™ENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY  RESPONSE. WASHINGTON. DC.
                                                                                                                                                   R2-4

-------
                             REFERENCES FOR  HEAST  TABLE  2:  ALTERNATE METHODS  -- SUBCHRONIC AND CHRONIC TOXICITY
                                                             (OTHER THAN CARCINOGENICITY)                                              May 19S5


NITROBENZENE                                               000098-95-3
        010518  CUT (CHEMICAL  INDUSTRY INSTITUTE OF TOXICOLOGY). 1984. NINETY- DAY INHALATION  STUDY OF NITROBENZENE IN F-344 RATS.CD RATS
                AND B6C3F1 MICE WITH COVER LETTER DATED 6/24/84 AND EPA RESPONSE DATED 8/06/84. UNPUBLISHED STUDY  FYI-OTS-0784-0333 AND
                COMPUTER PRINT-OUT OF PATHOLOGY  FINDING.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR NITROBENZENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF  EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON.
                DC.

TRICHLOROFLUOROHETHANE                                   000075-69-4
        005501  JENKINS. LJ. RA JONES. RA COON AND J SIEGAL. 1970. REPEATED AND CONTINUOUS EXPOSURES OF LABORATORY ANIMALS TO
                TRICHLOROFLUORMETHANE. TOXICOL APPL PHARMACOL.  16. 133-142.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.
                WASHINGTON. DC.
                                                                                                                                                R2-5

-------
                                                            HEAST  TABLE  3:   CARCINOGENICITY
CHEMICAL     ROUTE

ACEPHATE
             EXPERIMENT LENGTH
                 SPECIES
          TARGET

030560-19-1
CANCER
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)-'
                                                                              IRIS      IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                         Hay 1995

    [UNIT RISK]
 ORAL        INHALATION    REFERENCE
 (ug/L)'     (ug/cu m)-l
                                                                                                         IRIS
                                                                                                     010086
ACROLEIN
                          000107-02-8
                                                                              IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
                                                                                                                               005001
ACRYLAMIDE
                          000079-06-1
            ORAL- DRINKING
            WATER
                 2 YEARS
                 RAT
                                        IRIS
                      IRIS
                      4 5E+0
                                               MAMMARY
                                               THYROID
                                               UTERUS
                                               ORAL CAVITY
                                               CENTRAL NERVOUS
                                               SYSTEM
                                                     TUMORS
                                                     TUMORS
                                                     TUMORS
                                                     TUMORS
                                                     TUMORS
            INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
IRIS
IRIS
010087
ACRYLONITRILE
                          000107-13-1
                                                                              IRIS
                                                                            IRIS
                                                                               IRIS
                                                                         005004
            INHALATION:
            OCCUPATIONAL
                                                                  IRIS
                                                                2 4E-1
                HUMAN              LUNG               TUMORS

INHALATION  [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
                                                                                                                   IRIS
                                                                         005003
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                               3-1

-------
                                                             HEAST TABLE 3:   CARCINOGENICITY
                                                                                                                                  Hay 1995
CHEMICAL
ROUTE
EXPERIMENT LENGTH
    SPECIES
TARGET
CANCER
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
   [UNIT RISK]
ORAL        INHALATION   REFERENCE
(ug/L)'1     (ug/cu m)-l
ALACHLOR
ALDRIN
                          015972-60-8
 ORAL:  DIET     MULTIPLE SITES     TUMORS                         B2        8E-2
 ORAL [SLOPE]  COMMENT:  UNDER REVIEW.  NUMBER SUBJECT TO CHANGE.
 GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
            ORAL: DIET
                          000309-00-2

                MOUSE              LIVER
                                                     IRIS
                                        IRIS
                                    1 7E+1
                                                                  CARCINOMA
                                                                                                                      2.3E-6
                                     IRIS      IRIS
                                                                                                                   010180
                      005006
             INHALATION [SLOPE] COMMENT:   SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
             INHALATION [UNIT RISK] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)


ALLYL CHLORIDE                     000107-05-1
                                                                              IRIS                                                          010181
             GENERAL COMMENT:  FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT  SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC ASSESSMENT OF THIS
                         COMPOUND.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
ANILINE                              000062-53-3
                                                                               IRIS      IRIS
             GENERAL COMMENT:   ALSO SEE  HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
                                                                                                         IRIS
                                                                                                                   010088
ARAMITE
            ORAL: DIET
                 104 WKS
                 RAT
                          000140-57-8
                                               LIVER
                                                     IRIS
                                        IRIS
                                    2 5E-2
                                         TUMORS
                                     IRIS
         IRIS
010206
            INHALATION [SLOPE] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:   ALSO SEE  HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                3-2

-------
                                                            HEAST  TABLE  3:  CARCINOGENICITY
CHEMICAL     ROUTE

ARSENIC,  INORGANIC
             EXPERIMENT LENGTH
                 SPECIES
             INHALATION:
             OCCUPATIONAL
                 HUMAN
          TARGET

007440-38-2
         RESPIRATORY
         SYSTEM
 CANCER
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
                                                                  IRIS
                                                                5.0E+1
TUMORS
         INHALATION [SLOPE] COMMENT:   SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
ASBESTOS
                          001332-21-4
                                                                              IRIS
                                                                              IRIS
                        May 1995

   [UNIT RISK]
ORAL        INHALATION    REFERENCE
(ug/L) l     (ug/cu m)-l
                                                                                                                     IRIS
                                                             IRIS
                                                           010925

                                                           005007
                                                                                                                   IRIS
                                                                                                     005010
                                                                                                     005919
ATRAZINE
                          001912-24-9
            ORAL: DIET
                2 YEARS
                RAT
                                               MAMMARY GLAND
                                               MAMMARY GLAND
                                               MAMMARY GLAND
                                               MAMMARY GLAND
                           ADENOMA
                           FIBROADENOMA
                           ADENOCARCINOMA
                           CARCINOSARCOMA
                                                                                        2 22E-1
            ORAL [SLOPE] COMMENT:   UNDER REVIEU.  NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                               6.3E-6
                                                                          010380
AZOBENZENE                          000103-33-3
            ORAL: DIET       2 YEARS
                             RAT
                                                                  IRIS
                                                  IRIS
                                     1.1E-1
                                  ABDOMINAL CAVITY   SARCOMA

INHALATION  [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
                                     IRIS
         IRIS
010089
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                               3-3

-------
                                                           HEAST TABLE 3:   CARCINOGENICITY
                                                                                                                  May 1995
CHEMICAL     ROUTE
EXPERIMENT LENGTH
    SPECIES
          TARGET
BENZENE
            INHALATION:
            OCCUPATIONAL
    HUMAN
000071-43-2

         BLOOD
 CANCER
LEUKEMIA
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day)-'(mg/kg/day) '
                                                    IRIS      IRIS
                                    2 9E-2
            ORAL [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            INHALATION  [SLOPE] COMMENT:   SEE APPENDIX A-II. DOSE CONVERSIONS  ON HEAST.
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN  CARCINOGENICITY)
   [UNIT RISK]
ORAL        INHALATION   REFERENCE
(ug/L)'1     (ug/cu m)-l
                                    IRIS      IRIS
                     005011
BENZIDINE                           000092-87-5
                                                                             IRIS      IRIS          IRIS
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                          IRIS      IRIS
                                                                                                   005014
BENZOTRICHLORIDE

BENZO[A]ANTHRACENE
             000098-07-7

             000056-55-3
                                       IRIS

                                       IRIS
                      IRIS
                                    IRIS
                     010092

                     010182
BENZO[A]PYRENE.
             000050-32-8
                                                                             IRIS      IRIS
                                                                                          IRIS
                                                                                                   010508
BENZO[B]FLUORANTHENE
             000205-99-2
                                                                             IRIS
            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN  CARCINOGENICITY).
                                                                                                                010183
BENZO[K]FLUORANTHENE               000207-08-9
                                                                             IRIS                                                        010090
            GENERAL  COMMENT:  FOR RCRA ACTIVITIES ONLY.  CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC ASSESSMENT OF THIS
                        COMPOUND.
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                               3-4

-------
CHEMICAL    ROUTE

BENZYL CHLORIDE
                                                            HEAST  TABLE  3:  CARCINOGENICITY
             EXPERIMENT LENGTH
                 SPECIES            TARGET

                         000100-44-7
CANCER
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
                                                                             IRIS
                                                                           IRIS
                        Hay 1995

   [UNIT RISK]
ORAL        INHALATION    REFERENCE
(ug/L)'     (ug/cu m)-l
                                                  IRIS
                                                           010093
BERYLLIUM                           007440-41-7
                                                                             IRIS      IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
            INHALATION:
            OCCUPATIONAL
                                                                 IRIS
                                    8.4E+0
                HUMAN             LUNG              TUMORS

INHALATION  [SLOPE] COMMENT:   SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST.
                                                                                                       IRIS
                                              IRIS
                                                                        005018
                     005017
BIS(2-CHLOROETHYL) ETHER          000111-44-4
            ORAL            560 DAYS
                            MOUSE             LIVER
                                                                 IRIS      IRIS
                                    1.1E+0
                                     IRIS      IRIS
                                                    TUMORS

INHALATION  [SLOPE] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
BIS(2-CHLORO-1-METHYLETHYL) ETHER     000108-06-1
            ORAL: GAVAGE    2 YEARS
                            MOUSE             LIVER
                                              LUNG
                                                                          7E-2
                                    3  5E-2
                                     2E-6      1E-5
                                                    TUMORS
                                                    TUMORS
                     005076
                     005079
            INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION (50% RESPIRATORY  ABSORPTION)  SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  COMPOUND TESTED CONTAINED 70* BIS(2-CHLORO-1-METHYLETHYL)£THER AND 30* BIS(2-CHLOROISOPROPYL)ETHER. ALSO SEE HEAST TABLE  1:
                         SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
BIS(2-ETHYLHEXYL) PHTHALATE /  (DEHP)      000117-81-7
                                                                             IRIS      IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
                                                                                                        IRIS
                                                                        005120
IRIS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                             3-5

-------
                                                            HEAST TABLE 3:   CARCINOGENICITY
                                                                                                                    Nay 1995
CHEMICAL    ROUTE
EXPERIMENT LENGTH
    SPECIES            TARGET
BIS(CHLOROMETHYL) ETHER           000542-88-1
            INHALATION:      10-100  DAYS
            INTERMITTENT     RAT               RESPIRATORY
                                               SYSTEM
                                                                  CANCER
                                        TUMORS
                                                                               [SLOPE FACTOR]
                                                                  [EPA      ORAL         INHALATION
                                                                  GROUP] (mg/kg/day) Hmg/kg/day)'1
                                                     IRIS
                                                                          IRIS
                                                                             2.2E+2
            ORAL [SLOPE] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.



BROMODICHLOROMETHANE              000075-27-4
                                                                              IRIS      IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
BROMOETHENE  / (VINYL BROMIDE)   000593-60-2
             INHALATION:      2 YEARS
             INTERMITTENT     RAT               LIVER
                                                     B2
                                                                              1 1E-1
                                         TUMORS
             INHALATION [SLOPE] COMMENT:   SEE APPENDIX A-II:  DOSE  CONVERSIONS ON HEAST.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
 BROHOFORH
              000075-25-2
             ORAL: GAVAGE
    2 YEARS
    RAT
                                                                 IRIS
                                  INTESTINE.  LARGE   ADENOMATOUS POLYP
                                                    ADENOCARCINOMA
                                                                                        IRIS
                                                                              3  9E-3
                                                                                                                        [UNIT RISK]
                                                                                                                     ORAL        INHALATION    REFERENCE
                                                                                                                     (ug/L)'     (ug/cum)-l
                                                                                            IRIS
                                                                                                                 IRIS
                                                                                                                  005077
                                                                                            IRIS
                                                                                                      3.2E-5
                                                                                                                  005148
                                                                                                                              010094
                                                                                                                     IRIS
                                                                                                      IRIS
                                                                                                                                           005150
             INHALATION  [SLOPE] COMMENT-  BASED ON  ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
 BUTADIENE.  1.3-
             INHALATION:
             INTERMITTENT
                                                      IRIS
                          000106-99-0

                MOUSE             MULTIPLE SITES     TUMORS

INHALATION  [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
1 8E+0
                                                                                                      IRIS
                                     010477
 IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                           3-6

-------
CHEMICAL    ROUTE

BUTYL BENZYL PHTHALATE. N-
EXPERIMENT  LENGTH
    SPECIES
          TARGET

000085-68-7
CADMIUM
HEAST TABLE 3:   CARCINOGENICITY

                                [SLOPE  FACTOR]
                    [EPA      ORAL         INHALATION
      CANCER        GROUP]  (mg/kg/day) '(mg/kg/day)'
                                                                              IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
             007440-43-9
                                                                              IRIS
                                                     May 1995

                                 [UNIT RISK]
                              ORAL         INHALATION    REFERENCE
                              (ug/L)'      (ug/cu m)-l
                                                                                                                                           005122
            ORAL [SLOPE] COMMENT:  THERE IS INADEQUATE EVIDENCE FOR THE CARCINOGENICITY OF THIS COMPOUND BY THE ORAL ROUTE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
                                                                                                      IRIS
                                                                                                     005019
CAPTAFOL
CAPTAN
             002425-06-1
            ORAL: DIET
                                                               8  6E-3
                             MOUSE
                      LYMPHATIC  SYSTEM   LYMPHOSARCOMA
            ORAL [SLOPE] COMMENT:  UNDER REVIEW.  NUMBER  SUBJECT TO CHANGE.
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
             000133-06-2
                                                                              B2
                                                               3.5E-3
            ORAL [SLOPE] COMMENT:  UNDER REVIEW.  NUMBER  SUBJECT TO CHANGE.
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CARBAZOLE
            ORAL: DIET
    96 WEEKS
    MOUSE
             000086-74-8
                                               LIVER
                                        B2
                            2E-2
                           TUMORS
                                                                               2 4E-7
                                                                               1 OE-7
                             5.7E-7
                                                                                                                  010095
                                                                               010184
                                     010096
CARBON TETRACHLORIDE
            ORAL: DIET
             000056-23-5
                      LIVER
                           TUMORS
                  IRIS
IRIS
5.3E-2
IRIS
            INHALATION [SLOPE]  COMMENT:  SEE APPENDIX  A-II: DOSE CONVERSIONS ON HEAST
            INHALATION [UNIT RISK] COMMENT:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION.  INCORPORATES AN ABSORPTION FACTOR OF 0.4
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
IRIS
005022
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513)  569-7254.
                                                                                                                                  3-7

-------
                                                            HEAST TABLE 3:   CARCINOGENICITY
                                                                                                                    May 1995
CHEMICAL    ROUTE
EXPERIMENT  LENGTH
    SPECIES
          TARGET
CANCER
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP]  (mg/kg/day) '(mg/kg/day)'1
   [UNIT RISK]
ORAL        INHALATION
(ug/L)"'     (ug/cu m)-l
                                                                                                                                              REFERENCE
CHLORANIL
            ORAL: DIET
    82 WEEKS
    MOUSE
000118-75-2

         LIVER
         LUNG
                                                                 TUMORS
                                                                 TUMORS
                                                                                       4 03E-1
                                                  1 2E-5
                                                           010097
CHLORDANE
            ORAL: DIET
             000057-74-9

    MOUSE              LIVER
                                       IRIS
                                                                                       IRIS
                                    1 3E+0
                                     IRIS
                                                                 CARCINOMA
            INHALATION [SLOPE]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II:  DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLORO-2-METHYLANILINE HYDROCHLORIDE.  4-
            ORAL:'DIET       18 MONTHS
                                 003165-93-3
                                                    B2
                                                 4.6E-1
                                                  1 3E-5
                             MOUSE
CHLORO-2-METHYLANILINE. 4-
            ORAL: DIET      18 MONTHS
                            MOUSE
                      CARDIOVASCULAR     HEMANGIOMA
                      SYSTEM
                      CARDIOVASCULAR     HEMANGIOSARCOMA
                      SYSTEM

             000095-69-2
                                                    82
                                                 5 8E-1
                                                  1 6E-5
                      CARDIOVASCULAR     HEMANGIOMA
                      SYSTEM
                      CARDIOVASCULAR     HEMANGIOSARCOMA
                                               SYSTEM

            ORAL [SLOPE]  COMMENT:  BASED ON VASCULAR TUMORS IN MICE TREATED WITH 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE
         IRIS
005024
                                                                                                                                          010419
                                                           010098
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                3-8

-------
                                                            HEAST  TABLE  3:   CARCINOGENICITY                                            May 1995

                                                                                            [SLOPE FACTOR]               [UNIT RISK]
                         EXPERIMENT LENGTH                                       [EPA      ORAL          INHALATION     ORAL        INHALATION   REFERENCE
CHEMICAL    ROUTE            SPECIES            TARGET            CANCER        GROUP] (mg/kg/day) '(mg/kg/day) '       (ug/L)'1     (ug/cu m)-l

CHLOROBENZILATE                    000510-15-6
            ORAL: GAVAGE.    82 WEEKS                                          B2        2 7E-1         2 7E-1         7 8E-6    7.8E-5       010848
            DIET  '           MOUSE             LIVER              HEPATOMA

             INHALATION [SLOPE] COMMENT:  ABSORBANCE BY THE INHALATION  ROUTE WAS ASSUMED TO EQUAL ORAL ABSORPTION  SINCE THERE WERE NO
                       PHARMACOKINETIC DATA TO THE CONTRARY.  SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
             INHALATION [UNIT RISK] COMMENT:  ABSORBANCE BY THE INHALATION ROUTE WAS ASSUMED TO EQUAL ORAL ABSORPTION  SINCE THERE WERE NO
                       PHARMACOKINETIC DATA TO THE CONTRARY.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).


CHLOROFORM                          000067-66-3
                                                                              IRIS      IRIS                          IRIS                   005036

            ORAL: GAVAGE     78 WEEKS                                          IRIS                     8 1E-2                   IRIS         005035
                             MOUSE             LIVER              CARCINOMA

             INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II. DOSE CONVERSIONS ON  HEAST
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY).


CHLOROMETHANE                      000074-87-3
            INHALATION:      24 MONTHS                                         C         1 3E-2         6 3E-3         3  7E-7     1  8E-6       005038
            INTERMITTENT     MOUSE             KIDNEY             TUMORS


         ORAL [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENCIITY)

CHLOROMETHYL METHYL ETHER        000107-30-2
                                                                               IRIS                                                          005081
            GENERAL COMMENT:  FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT  SECTION (202) 260-4761 FOR RCRA APPROVED
                       NUMERIC ASSESSMENT OF THIS COMPOUND.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION  RISK INFORMATION HOTLINE-  (513) 569-7254.                             3-9

-------
                                                            HEAST TABLE 3:   CARCINOGENICITY
                                                                                                                Hay 1995
                         EXPERIMENT LENGTH
CHEMICAL     ROUTE             SPECIES
CHLORONITROBENZENE.  0-
            ORAL: DIET       18 MONTHS
                             MOUSE
                   TARGET

          000088-73-3

                  LIVER
                            CANCER
                           TUMORS
                           [SLOPE  FACTOR]
               [EPA      ORAL         INHALATION
               GROUP]  (ing/kg/day) '(ing/kg/day)'
                                        B2        2.5E-2
   [UNIT RISK]
ORAL        INHALATION
(ug/L)'     (ug/cu m)-l
                                                                                                                  REFERENCE
                                                   7.1E-7
                     010099
CHLORONITROBENZENE.  P-
            ORAL: DIET
          000100-00-5
18 MONTHS
MOUSE
                                               CARDIOVASCULAR
                                               SYSTEM
                           TUMORS
                                        B2
                                                                                        1.8E-2
                                                   5.1E-7
                                                                                                    010100
CHLOROTHALONIL
            ORAL: DIET
          001897-45-6
27-32 MONTHS
RAT               KIDNEY
                                                                 TUMOR
                                        B2
                                                                                       1.1E-2
            ORAL [SLOPE] COMMENT:   UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
CHROMIUH(VI)
            INHALATION:
            OCCUPATIONAL
HUMAN
018540-29-9

         LUNG
                                                 IRIS
                                     4.1E+1
TUMORS
            INHALATION [SLOPE]  COMMENT:  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
                                                   3.1E-7
         IRIS
                                                                                                    010384
005091
CHRYSENE
         000218-01-9
                                                                              IRIS
            GENERAL COMMENT:   FOR  RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761  FOR RCRA APPROVED NUMERIC
                       ASSESSMENT  OF THIS COMPOUND.  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                                          010185
IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                            3-10

-------
                                                           HEAST  TABLE  3:  CARCINOGENICITY
CHEMICAL     ROUTE
EXPERIMENT LENGTH
    SPECIES
COKE OVEN  EMISSIONS
            INHALATION:
            OCCUPATIONAL     HUMAN
          TARGET

008007-45-2

         LUNG
                                                                 CANCER
                                       TUMORS
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP]  (mg/kg/day) Hmg/kg/day)'1
                                                    IRIS
                                                                           2.2E+0
            INHALATION  [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
            GENERAL COMMENT:  FORMERLY  LISTED UNDER COAL TARS.
                                                                                                     Hay 1995

                                                                                 [UNIT RISK]
                                                                              ORAL       INHALATION   REFERENCE
                                                                              (ug/L)'     (ug/cu m)-l
                                                                                                   IRIS
                                                          005039
CREOSOTE.  COAL  TAR
             008001-58-9
                                                                             IRIS
                                                                                                                                        005042
CRESOL.  M- /  (3-METHYLPHENOL)   000108-39-4
                                                                             IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                                                                        010187
CRESOL.  0- /  (2-METHYLPHENOL)    000095-48-7
                                                                             IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                        010186
CRESOL.  P- /  (4-METHYLPHENOL)    000106-44-5
                                                                             IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
 CROTONALDEHYDE                     000123-73-9
            ORAL: DRINKING   113 WKS
            WATER            RAT                LIVER
                                                     IRIS
                                                 1 9E+0
                                        TUMOR
             ORAL [SLOPE] COMMENT:  UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
                                                                                           5.4E-5
                                                                                                                                         010188
                                                                                                                010190
 IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                       3-11

-------
                                                            HEAST TABLE 3:   CARCINOGENICITY
                                                                                                                                             Nay 1995
 CHEMICAL     ROUTE

 CYANAZINE
EXPERIMENT LENGTH
    SPECIES
             ORAL: DIET
    2 YEARS
    RAT
          TARGET

021725-46-2

         MAMMARY GLAND
                                         CANCER
                                                                 ADENOMA/
                                                                 CARCINOMA.
                                                                 COMBINED
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-'
                                                                                       8.4E-1
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
   [UNIT RISK]
ORAL        INHALATION    REFERENCE
(ug/L)-1     (ug/cumM
                                                                                                                    2.4E-5
                                                           010944
ODD
             000072-54-8
                                                                              IRIS
                                                              IRIS
                                                                              IRIS
                                                                                                                                          010291
DDE
             000072-55-9
                                                                              IRIS      IRIS
                                                                                           IRIS
                                                                                                                                          010292
DDT
            ORAL: DIET
             000050-29-3

   MOUSE, RAT         LIVER
                                                                              IRIS      IRIS
                                                               3 4E-1
                                                                 TUMORS
                                     IRIS      IRIS
            INHALATION [SLOPE]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                          005044
DECABROMODIPHENYL ETHER
             001163-19-5
                                                                              IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                                          010102
DIALLATE
             002303-16-4
            ORAL
   19 MONTHS
   MOUSE
                                                                             B2
                                                 6  1E-2
                                               LIVER
                                                                                                                    1 7E-6
                          TUMORS
                                                                                                    010103
IRIS,  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION  RISK INFORMATION HOTLINE:  (513) 569-7254
                                                                                                                                                         3-12

-------
                                                            HEAST TABLE 3:   CARCINOGEN1CITY
                                                                                                                                             Hay 1995
CHEMICAL    ROUTE

DIBENZO[A.H]ANTHRACENE
                         EXPERIMENT LENGTH
                             SPECIES             TARGET
                                             [SLOPE FACTOR]               [UNIT RISK]
                                 [EPA       ORAL          INHALATION     ORAL        INHALATION    REFERENCE
                   CANCER        GROUP] (mg/kg/day) '(mg/kg/day)'       (ug/L)'1     (ug/cu m)-l
                                      000053-70-3
                                                                              IRIS                                                         010191
            GENERAL COMMENT:   FOR RCRA ACTIVITIES  ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761  FOR RCRA APPROVED
                       NUMERIC ASSESSMENT OF THIS  COMPOUND.
DIBROMO-3-CHLOROPROPANE,  1.2     000096-12-8
            ORAL: DIET                                                        B2        1 4E+0                       4E-5                  010484
                                               STOMACH            TUMORS
                                               KIDNEY             TUMORS
                                               LIVER             TUMORS

            [EPA GROUP] COMMENT:  UNDER REVIEW.  CLASSIFICATION SUBJECT TO CHANGE.
            INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
             INHALATION:
             INTERMITTENT
                                                                              B2
                                                                                                      2 4E-3
                                                                                                                              6.9E-7
                             RAT. MOUSE
NASAL CAVITY
TUMORS
                                                                                                                                           010519
DIBROHOCHLOROMETHANE              000124-48-1
                                                                              IRIS      IRIS                          IRIS
            GENERAL COMMENT:  FORMERLY LISTED AS CHLORODIBROMOMETHANE. ALSO SEE HEAST TABLE  1. SUBCHRONIC AND CHRONIC TOXICITY
                       (OTHER THAN CARCINOGENICITY).
                                                                                                                                           010891
DIBROMOETHANE.  1.2-               000106-93-4

            GENERAL COMMENT:  FORMERLY LISTED UNDER ETHYLENE DIBROMIDE
                                                                              IRIS
                                         IRIS
                                                                                                                     IRIS
                                                                                            005818
             INHALATION:
             INTERMITTENT
                             88-103 WEEKS
                             RAT
                                                                              IRIS
                                                                                                      7 6E-1
                                                                                                                               IRIS
NASAL CAVITY
TUMORS
             INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
                                                                                                                                           005071
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                          3-13

-------
                                                            HEAST TABLE 3:   CARCINOGENICITY
                                                                                                                   Nay 1995
CHEMICAL    ROUTE
EXPERIMENT LENGTH
    SPECIES
DICHLORO-2-BUTENE.  1.4-
            INHALATION:      90 DAYS
            INTERMITTENT     RAT
          TARGET             CANCER

000764-41-0

         NASAL PASSAGES     TUMORS
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'
                                                    82
                      9.3E+0
            INHALATION [SLOPE]  COMMENT:  SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  FORMERLY LISTED UNDER DICHLOROBUTENES
DICHLOROBENZENE. 1.4-             000106-46-7
            ORAL: GAVAGE     103 WEEKS
                             MOUSE              LIVER
                                                              2.4E-2
                                        TUMORS
            ORAL [SLOPE] COMMENT:  UNDER REVIEW.  NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
     [UNIT RISK]
  ORAL        INHALATION    REFERENCE
  (ug/L)'1     (ug/cu m)-l
          2.6E-3
             005053
                                                                              6.8E-7
                                                           005050
DICHLOROBENZIDINE.  3.3'-
             000091-94-1
                                                                             IRIS
                                                              IRIS
                                                                              IRIS
                                                           005815
DICHLOROETHANE.  1.1-
             000075-34-3
                                                                             IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
                                                                                                                 005055
DICHLOROETHANE.  1.2-
            ORAL: GAVAGE
             000107-06-2
    78 WEEKS
    RAT
                                                                            IRIS
                                                IRIS
                     9.1E-2
                                               CIRCULATORY
                                               SYSTEM
                           SARCOMA
IRIS
IRIS
005058
            INHALATION [SLOPE] COMMENT:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                               3-14

-------
                                                            HEAST TABLE 3:   CARCINOGENICITY                                            May 1995

                                                                                            [SLOPE  FACTOR]                [UNIT RISK]
                         EXPERIMENT LENGTH                                       [EPA       ORAL         INHALATION      ORAL        INHALATION    REFERENCE
CHEMICAL    ROUTE            SPECIES            TARGET            CANCER        GROUP]  (mg/kg/day) Hmg/kg/day)'        (ug/L) '     (ug/cu m)-l

DICHLOROETHYLENE.  1.1-            000075-35-4
                                                                              IRIS       IRIS                          IRIS                   005060

            INHALATION       12 MONTHS                                         IRIS                     1 2E+0                  IRIS         005059
                             MOUSE              KIDNEY             ADENOCARCINOMA

            INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

DICHLOROPROPANE. 1.2-             000078-87-5
            ORAL: GAVAGE                                                      B2        6.8E-2                        1.9E-6                 005062
                             MOUSE              LIVER              TUMORS

            ORAL [SLOPE] COMMENT:  UNDER REVIEW.  NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS. EPA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UP047FO MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE.  (513) 569-7254.                            3-15

-------
                                                             HEAST TABLE 3:   CARCINOGEN1CITY
                                                                                                                  Nay 1995
                         EXPERIMENT LENGTH
CHEMICAL    ROUTE

DICHLOROPROPENE.  1.3
            ORAL: GAVAGE
DIELDRIN
            ORAL: GAVAGE
SPECIES
/ (TELONE II)
104 WEEKS
MOUSE





104 WEEKS
RAT
TARGET
000542-75-6

BLADDER
RESPIRATORY
SYSTEM

FORESTOMACH


LIVER
CANCER


CARCINOMA
ALVEOLAR/
BRONCHIOLAR
ADENOMA
PAPILLOMA/
CARCINOMA

NEOPLASTIC
GRI

IRIS








NODULE/CARCINOMA


FORESTOMACH

PAPILLOMA/
CARCINOMA


                                                                [SLOPE FACTOR]
                                                    [EPA      ORAL         INHALATION
                                                    GROUP]  (mg/kg/day) '(mg/kg/day)-1
                                                            1 8E-1
            ORAL [SLOPE] COMMENT:  THE [SLOPE]  IS THE GEOMETRIC MEAN OF SLOPE FACTORS OF COMBINED TUMORS  LISTED.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
             INHALATION:
             INTERMITTENT
2 YEARS
MOUSE
                               IRIS
                                                                                                        1.3E-1
LUNG
ADENOMA
             INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
            ORAL: DIET
          000060-57-1

MOUSE              LIVER
                               IRIS
                       IRIS
1.6E+1
                                                                  CARCINOMA
             INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
             INHALATION [UNIT RISK] COMMENT:   BASED ON ROUTE-TO-ROUTE EXTRAPOLATION.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                           [UNIT RISK]
                                                                       ORAL        INHALATION    REFERENCE
                                                                       (ug/L)'     (ug/cu m)-l
                                                                      5E-6
                                                                           010946
                                                                                                   3.7E-5
                                                                           010104
IRIS
                                                                                                                                IRIS
005816
IRIS,  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
                                                                                                                               3-16

-------
                                                          HEAST TABLE 3:   CARCINOGENICITY
 CHEMICAL    ROUTE

 DIETHYLSTILBESTROL
            ORAL:  DIET
EXPERIMENT LENGTH
    SPECIES            TARGET            CANCER

             000056-53-1

   MOUSE             MAMMARY GLAND      CARCINOMA
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP]  (mg/kg/day) '(mg/kg/day)'
                                                                                     4  7E+3
                        Hay 1995

    [UNIT RISK]
 ORAL       INHALATION    REFERENCE
 (ug/L)'1    (ug/cu m)-l
                                    1.3E-1
                     010485
DIMETHOXYBENZIDINE. 3.3'-        000119-90-4
            ORAL:  DIET      LIFETIME
                            HAMSTER           FORESTOMACH
                                                   82
                                       PAPILLOMA
        1.4E-2
4E-7
010106
DIMETHYLANILINE  HYDROCHLORIDE.  2.4-    021436-96-4
            ORAL: DIET       18 MONTHS
                            MOUSE             LUNG
                                       TUMORS
                                                            5.8E-1
                                    1.7E-5
                      010108
DIMETHYLANILINE.  2.4-             000095-68-1
            ORAL:  DIET       18 MONTHS
                            MOUSE             LUNG
                                       TUMORS
                                                            7 5E-1
                                    2.1E-5
                      010107
DIMETHYLBENZIDINE.  3.31-          000119-93-7
            ORAL: GAVAGE     30  DAYS
                            RAT              MAMMARY
                                      TUMORS
                                                   B2
       9 2E+0
2.6E-4
                                                                                                              010109
DIMETHYLBENZ[A]ANTHRACENE. 7.12-      000057-97-6

            GENERAL COMMENT:   FOR RCRA ACTIVITIES ONLY.  CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED
                      NUMERIC ASSESSMENT OF THIS COMPOUND.
                                                                                                              010297
DIMETHYLHYDRAZINE.  1.1-           000057-14-7
            GENERAL COMMENT:   NO EPA GROUP CLASSIFICATION WAS PROVIDED IN THE REFERENCE DOCUMENT. THEREFORE THIS COMPOUND WAS
                      REMOVED FROM TABLE 3.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                            3-17

-------
                                                           HEAST  TABLE  3:  CARCINOGEN1CITY
                                                                                                                              Nay 1995
CHEMICAL     ROUTE

DIMETHYLHYDRAZINE.  1.2-


DIMETHYLSULFATE
            EXPERIMENT LENGTH
                SPECIES
          TARGET

000540-73-8


000077-78-1
CANCER
            [SLOPE  FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(nig/kg/day)'
                                                                B2
                                                                            IRIS
   [UNIT RISK]
ORAL        INHALATION   REFERENCE
(ug/L)'     (ug/cu m)-l
                                                                       010962
                                                                                                                            010112
DINITROTOLUENE.  2.4-              000121-14-2
                                                                            IRIS      IRIS                         IRIS
            GENERAL COMMENT:  LISTED AS  "DINITROTOLUENE MIXTURE. 2.4-72.6-" ON IRIS. ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC
                      TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                            005066
DINITROTOLUENE.  2.6-              000606-20-2
                                                                            IRIS      IRIS                         IRIS
            GENERAL COMMENT:  LISTED AS  "DINITROTOLUENE MIXTURE. 2.4-/2.6-" ON IRIS. ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC
                      TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                            005068
DIOXANE.  1.4-
                         000123-91-1
                                                                            IRIS
                                                                          IRIS
                                                                             IRIS
                                                                       010298
DIPHENYLHYDRAZINE. 1.2-          000122-66-7
            ORAL:  DIET       2 YEARS
                            RAT               LIVER
                                                                IRIS      IRIS
                                                               8.0E-1
                                                  IRIS      IRIS
                                                    TUMORS

INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
                                                          005070
DIRECT BLACK 38
            ORAL:  DIET
                         001937-37-7
                93 DAYS
                RAT
                                                 8 6E+0
                                                                                                      2.4E-4
                                              LIVER             TUMORS

            ORAL [SLOPE] COMMENT:  UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
                                                                       010113
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                          3-18

-------
                                                            HEAST TABLE 3:   CARCINOGEN1CITY
CHEMICAL     ROUTE
EXPERIMENT  LENGTH
    SPECIES
                                                                  CANCER
DIRECT  BLUE  6
            ORAL: DIET
DIRECT  BROWN  95
            ORAL: DIET
                                    TARGET

                          002602-46-2

                                  LIVER              TUMORS

ORAL [SLOPE]  COMMENT:  UNDER REVIEW.  NUMBER SUBJECT TO CHANGE.

                          016071-86-6

                                  LIVER              TUMORS

 ORAL [SLOPE] COMMENT:  UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
    91  DAYS
    RAT
    91 DAYS
    RAT
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
G'ROUP] (mg/kg/day) '(mg/kg/day)'1
                                                                                       8.1E+0
                                                                                       9.3E+0
                        May 1995

   [UNIT RISK]
ORAL        INHALATION    REFERENCE
(ug/L)•'     (ug/cu m)-l
                                     2.3E-4
                                     2.6E-4
                     010114
                     010115
DIRECT SKY BLUE 6B
             002610-05-1
                                                                              82
            [EPA GROUP] COMMENT:   BASED ON THE FACT THAT 3.3-DIMETHOXYBENZIDINE.  A KNOWN EPA GROUP B2 CARCINOGEN.  IS A METABOLITE
                           OF DIRECT SKY BLUE 6B.
EPICHLOROHYDRIN
            INHALATION:
            INTERMITTENT
             000106-89-8
   30 DAYS.
   OBSERVED LIFETIME
   RAT                NASAL CAVITY
                                                                 IRIS

                                                                 IRIS
                                                                                        IRIS
                                                                                           IRIS
                      4 2E-3
         IRIS
                                                                 TUMORS
            INHALATION [SLOPE]  COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
                                                                                                                 010116
010198

010117
ETHYL ACRYLATE
            ORAL: GAVAGE
             000140-88-5
   104 WEEKS
   RAT
                                                                              B2
                                                                           4.8E-2
                                               FORESTOMACH
                                     1.4E-6
                                                     TUMORS
                                                                                                                                           010118
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                3-19

-------
                                                            HEAST TABLE  3:   CARCINOGENICITY
                                                                                                                                 Hay 1995
CHEMICAL    ROUTE

ETHYLENE  OXIDE
            ORAL: GAVAGE
             EXPERIMENT LENGTH
                 SPECIES
 TARGET
                           [SLOPE FACTOR]
               [EPA       ORAL          INHALATION
 CANCER        GROUP]  (mg/kg/day) Hmg/kg/day)'
                          000075-21-8
                LIFETIME. TWICE WEEKLY
                RAT                STOMACH
                                                                 TUMORS

            ORAL [SLOPE] COMMENT:   UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
            INHALATION:
            INTERMITTENT
                2 YEARS
                RAT
BLOOD
BRAIN
LEUKEMIA
GLIOMA
                               Bl         1 02E+0
                               Bl                      3.5E-1
ETHYLENE  THIOUREA
            ORAL: GAVAGE
INHALATION  [UNIT RISK] COMMENT:  UNDER REVIEW. NUMBER SUBJECT TO CHANGE.

                          000096-45-7
                2 YEARS
                MOUSE
                                               LIVER
                               B2
                  ADENOMA/
                  CARCINOMA, COMBINED
                       1.1E-1
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
    [UNIT RISK]
 ORAL        INHALATION    REFERENCE
 (ug/L)'1     (ug/cu m)-l
                                                    2.9E-5
                                                             1E-4
3.4E-6
                      010421
                      010422
010947
FOLPET                               000133-07-3
                                                                              IRIS      IRIS
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
                                                                                                         IRIS
                                                                                            010120
FORMALDEHYDE
            INHALATION
                          000050-00-0
                24 MONTHS
                RAT
                               IRIS
                                     4 5E-2
                                               NASAL CAVITY
                  TUMORS
            INHALATION [SLOPE]  COMMENT:  SEE APPENDIX A-II:  DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
          IRIS
010121
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE.  (513) 569-7254.
                                                                                                                                              3-20

-------
                                                            HEAST TABLE  3:  CARCINOGEN1CITY
CHEMICAL     ROUTE
EXPERIMENT  LENGTH
    SPECIES
FURAZOLIDONE
            ORAL: DIET
    45 WEEKS
    RAT
                                                                  CANCER
                                    TARGET

                          000067-45-8

                                   MAMMARY            TUMORS

GENERAL COMMENT:   FORMERLY LISTED UNDER  NITROFURANS
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'
                                                                              B2        3 8E+0
                         Hay 1995

    [UNIT RISK]
 ORAL        INHALATION    REFERENCE
 (ug/L) '     (ug/cu m)-l
                                     1E-4
                      005106
FURIUM
             000531-82-8
            ORAL: DIET
    28 WEEKS
    MOUSE
                                               BLOOD

            GENERAL COMMENT:  FORMERLY LISTED UNDER NITROFURANS
                                                     LEUKEMIA
                                                                              B2
                                                                           5 OE+1
                                     1.4E-3
                      005108
6LYCIDALDEHYDE
             000765-34-4
                                                                              IRIS
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY).
HEPTACHLOR
            ORAL: DIET
             000076-44-8

   MOUSE              LIVER
                                                                              IRIS
                                                                           IRIS
                      4 5E+0
                                                                 CARCINOMA
IRIS
            INHALATION [SLOPE] COMMENT:  BASED ON ROUTE  TO  ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:   ALSO  SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
HEPTACHLOR EPOXIDE
            ORAL: DIET
             001024-57-3
   18-24 MONTHS
   MOUSE              LIVER
                                                                              IRIS
                                                                           IRIS
                      9 1E+0
IRIS
                                                                 CARCINOMA
            INHALATION [SLOPE]  COMMENT:  BASED ON ROUTE  TO  ROUTE EXTRAPOLATION.  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
IRIS
                                                                                                                  010122
005820
010424
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION- RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                 3-21

-------
                                                           HEAST TABLE 3:   CARCINOGEN1CITY
                                                                                                                                           Hay 1995
CHEMICAL     ROUTE

HEXACHLOROBENZENE
            ORAL: DIET
                        EXPERIMENT LENGTH
                            SPECIES
                            RAT
          TARGET

000118-74-1

         LIVER
                                                                 CANCER
                                                                TUMORS
            [SLOPE FACTOR]                [UNIT RISK]
[EPA      ORAL         INHALATION      ORAL        INHALATION   REFERENCE
GROUP] (mg/kg/day) '(mg/kg/day) '        (ug/L) >     (ug/cu m)-l
                                                                            IRIS
        IRIS
                                                                                                    1 6E+0
                                     IRIS
            INHALATION  [SLOPE] COMMENT-   BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
IRIS
                                                                                                                                         010365
HEXACHLOROBUTAOIENE                000087-68-3
            ORAL:  DIET      22-24 MONTHS
                            RAT               KIDNEY
                                                                            IRIS      IRIS
                                                               7 8E-2
                                                                                                                   IRIS
                                                                TUMORS
            INHALATION [SLOPE] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE  APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
HEXACHLOROCYCLOHEXANE.  ALPHA-    000319-84-6
            ORAL: DIET      24 WEEKS
                            MOUSE             LIVER
                                                                             IRIS
                                                 IRIS
                                                                                                    6.3E+0
                                                                              IRIS
                                                                TUMORS

            INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST.
HEXACHLOROCYCLOHEXANE. BETA-      000319-85-7
            ORAL: DIET       110 WEEKS
                             MOUSE              LIVER
                                                                             IRIS
                                                 IRIS
                                                                                                     1 8E+0
                                                                              IRIS
                                                                TUMORS

            INHALATION [SLOPE] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST
                                                                                       IRIS
                                                                                                                             IRIS
                                               IRIS
                                                                                                                                         005088
                                                           010123
                                                                                                                                         010124
HEXACHLOROCYCLOHEXANE. DELTA-    000319-86-8
                                                                             IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
                                                                                                                                          010125
                                                                             IRIS
HEXACHLOROCYCLOHEXANE.  EPSILON-    006108-10-7

            GENERAL  COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)

IRIS.  ERA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER  INFORMATION- RISK INFORMATION HOTLINE  (513) 569-7254.
                                                                                                                                          010126
                                                                                                                                                        3-22

-------
                                                            HEAST TABLE 3:   CARCINOGENICITY
 CHEMICAL     ROUTE
             EXPERIMENT LENGTH
                 SPECIES
                                                TARGET
CANCER
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(ing/kg/day)'1
                                                                                                                                 May 1995
    [UNIT RISK]
 ORAL        INHALATION
 (ug/L) '     (ug/cu m)-l
                                                                                                                                              REFERENCE
 HEXACHLOROCYCLOHEXANE,  GAMMA-    000058-89-9
             ORAL: DIET       110 WEEKS
                             MOUSE             LIVER
                                                                 B2-C
                     1 3E+0
                                                     TUMORS
             ORAL [SLOPE] COMMENT:   UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                     3.7E-5
                      005098
HEXACHLOROCYCLOHEXANE-TECHNICAL  000608-73-1
            ORAL: DIET       6-20 MONTHS
                             MOUSE             LIVER
                                                                  IRIS      IRIS
                                    1.8E+0
                                     IRIS       IRIS
                                                     TUMORS

INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST.
                      010127
HEXACHLOROETHANE                   000067-72-1
            ORAL: GAVAGE     78 WEEKS
                             MOUSE              LIVER
                                                                  IRIS
                     IRIS
                      1 4E-2
IRIS
                                                     CARCINOMA
             INHALATION [SLOPE]  COMMENT:  BASED ON ROUTE  TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II. DOSE CONVERSIONS  ON  HEAST.
            GENERAL COMMENT:  ALSO  SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
HYDRAZINE
                          000302-01-2
            INHALATION:      1  YEAR
            INTERMITTENT     RAT
                                                                  IRIS

                                                                  IRIS
                                                                                        IRIS
                                                  IRIS
                                    1  7E+1
                                  NASAL CAVITY       TUMORS

INHALATION  [SLOPE] COMMENT:   SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
IRIS
                                               IRIS
005090
                      010129

                      010128
IRIS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                             3-23

-------
CHEMICAL     ROUTE

HYDRAZINE SULFATE
EXPERIMENT LENGTH
    SPECIES            TARGET

             010034-93-2
                                                           HEAST TABLE 3:   CARCINOGENICITY

                                                                                           [SLOPE FACTOR]
                                                                               [EPA      ORAL          INHALATION
                                                                 CANCER        GROUP]  (mg/kg/day) '(mg/kg/day)'1
            INHALATION:       1 YEAR
            INTERMITTENT     RAT
                                                                             IRIS      IRIS

                                                                             IRIS
                                                                            1 7E+1
                      NASAL  CAVITY       TUMORS
             INHALATION [SLOPE]  COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
            GENERAL COMMENT:  LISTED UNDER "HYDRAZINE" ON IRIS.
                        Hay 1995

   [UNIT RISK]
ORAL        INHALATION    REFERENCE
(ug/L)'     (ug/cu m)-l
                                                                                                                    IRIS
                                                                                                     IRIS
                                                                                                                 010131

                                                                                                                 010130
 INDENO[1.2.3-CD]PYRENE
             000193-39-5
                                                                             IRIS
                                                                                                                 010192
 ISOPHORONE                          000078-59-1

            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                 005094
 LEAD
                                      007439-92-1
                                                                              IRIS
             GENERAL  COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
                                                                                                                                          005096
 LINURON
              000330-55-2
                                                                              IRIS
             GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
                                                                                                                                          010383
 MERCURIC  CHLORIDE
               007487-94-7
                                                                                IRIS
             GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                                              010971
 IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                                         3-24

-------
                                                           HEAST TABLE 3:   CARCINOGEN1CITY                                           May 1995

                                                                                          [SLOPE FACTOR]               [UNIT RISK]
                         EXPERIMENT LENGTH                                     [EPA      ORAL         INHALATION     ORAL        INHALATION    REFERENCE
 CHEMICAL     ROUTE            SPECIES            TARGET            CANCER       GROUP] (mg/kg/day) '(mg/kg/day)'1       (ug/L)'1     (ug/cu m)-l

 MERCURY.  ELEMENTAL                 007439-97-6
                                                                              IRIS                                                          010973
             GENERAL COMMENT: ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN ICITY).

 METHOXY-5-NITROANILINE. 2-        000099-59-2
             ORAL: DIET      104 WEEKS                                       B2        4 6E-2                       1 3E-6                010132
                            RAT               SKIN               CARCINOMA


 METHYLHYDRAZINE                    000060-34-4
             GENERAL COMMENT:  NO EPA GROUP CLASSIFICATION WAS PROVIDED IN  THE REFERENCE DOCUMENT. THEREFORE THIS  COMPOUND WAS REMOVED FROM TABLE 3.


 METHYL-5-NITROANILINE.  2-         000099-55-8
             ORAL: DIET      98 WEEKS                                        C         3.3E-2                       9 4E-7                010140
                            MOUSE             LIVER             CARCINOMA


 METHYLANILINE  HYDROCHLORIDE.  2-    000636-21-5
            ORAL: DIET      93 WEEKS                                        B2        1.8E-1                       5 1E-6                010134
                            RAT               SKIN               FIBROMA


 METHYLANILINE.  2-                  000095-53-4
            ORAL: DIET      93 WEEKS                                         B2        2.4E-1                       6 9E-6                010133
                            RAT               SKIN               FIBROMA

            GENERAL COMMENT:  THE 1984 HEEP CALLED THIS COMPOUND 0-TOLUIDINE. THE 1987 HEEP CALLED IT 2-METHYLANILINE.


METHYLCHOLANTHRACENE. 3-           000056-49-5
                                                                                                                                        010299
            GENERAL COMMENT:  FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR  RCRA APPROVED
                      NUMERIC ASSESSMENT OF THIS COMPOUND



IRIS. EPA'S INTEGRATED RISK  INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.                           3-25

-------
                                                          HEAST TABLE 3:   CARCINOGENICITY                                            Hay 1995

                                                                                         [SLOPE FACTOR]               [UNIT RISK]
                        FXPFRIMENT  LENGTH                                      [EPA      ORAL         INHALATION     ORAL        INHALATION    REFERENCE
CHEMICAL     ROUTE            SPECIES            TARGET            CANCER        GROUP] (mg/kg/day) "(mg/kg/day)'       (ug/L)'1     (ug/cu m)-l


METHYLENE  CHLORIDE / (DICHLOROMETHANE)       000075-09-2
                                                                            IRIS      IRIS                         IRIS                  005100
                                                                            IRIS                                            IRIS        005904

            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)



METHYLENE-BIS(BENZENEAMINE). 4.4-  /  (4.4'-METHYLENEDIANILINE)         000101-77-9
            GENERAL COMMENT:  NO EPA GROUP CLASSIFICATION WAS PROVIDED  IN THE REFERENCE DOCUMENT.  THEREFORE THIS COMPOUND  WAS REMOVED FROM TABLE  3.


METHYLENE-BISC2-CHLOROANILINE). 4.41-  000101-14-4
            ORAL-  DIET       2 YEARS                                         B2       1.3E-1         1.3E-1         3.7E-6    3.7E-5      010425
                            RAT               LUNG             TUMORS

            INHALATION  [SLOPE] COMMENT:   SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST  BASED ON ROUTE TO ROUTE EXTRAPOLATION.

METHYLENE-BIS(N.N'-DIMETHYL)ANILINE.  4.41-  000101-61-1
                                                                            IRIS     IRIS                         IRIS                  010137
            GENERAL COMMENT:  ALSO SEE  HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).


METHYLMERCURY                      0022967-92-6
                                                                              IRIS                                                          010972
            GENERAL  COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).


METOLACHLOR                        051218-45-2
                                                                            IRIS                                                       010951


                                     002385-85-5
            ORAL: DIET      2 YEARS                                         B2
                            RAT               LIVER             ADENOMA
                                              LIVER             CARCINOMA

            [EPA GROUP] COMMENT:  UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)




 IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.                           3-26

-------
                                                             HEAST TABLE 3:   CARCINOGENICITY                                             Hay 1995

                                                                                             [SLOPE  FACTOR]                [UNIT RISK]
                          EXPERIMENT LENGTH                                       [EPA      ORAL         INHALATION      ORAL         INHALATION    REFERENCE
 CHEMICAL     ROUTE            SPECIES             TARGET             CANCER        GROUP]  (mg/kg/day) '(mg/kg/day)'        (ug/L)'      (ug/cu m)-l

 NIAGARA BLUE 48                    002429-74-5
                                                                               B2                                                           010141

             [EPA GROUP]  COMMENT:  BASED ON THE FACT  THAT 3.3-DIMETHOXYBENZIDINE.  A KNOWN  EPA GROUP B2 CARCINOGEN  IS  A
                       METABOLITE OF NIAGARA BLUE 4B.


 NICKEL REFINERY DUST
             INHALATION:                                                        IRIS                     8.4E-1                  IRIS         005103
             OCCUPATIONAL    HUMAN             RESPIRATORY        TUMORS
                                               SYSTEM

             INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON  HEAST.
             GENERAL COMMENT:  FORMERLY LISTED AS  NICKEL. ALSO SEE HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (UNDER NICKEL. SOLUBLE SALTS).

 NICKEL SUBSULFIDE                   012035-72-2
             INHALATION:                                                        IRIS                     l 7E+0                  IRIS         005768
             OCCUPATIONAL    HUMAN             RESPIRATORY        TUMORS
                                               SYSTEM

             INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II. DOSE CONVERSIONS ON  HEAST.
             GENERAL COMMENT:  FORMERLY LISTED AS  NICKEL. ALSO SEE HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (UNDER NICKEL).
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE: (513) 569-7254.                             3-27

-------
                                                            HEAST  TABLE  3:  CARCINOGENICITY
                                                                                                                                Hay 1995
                         EXPERIMENT LENGTH
CHEMICAL    ROUTE

NITROBENZENE
            INHALATION
            INHALATION
SPECIES

2 YEAR
MICE



2 YEAR
RAT




TARGET
000098-95-3

LUNG
LUNG
THYROID
MAMMARY

LIVER
LIVER
KIDNEY
KIDNEY
UTERUS
CANCER GROUI

B2
ADENOMA
CARCINOMA
ADENOMA
ADENOCARCINOMA

ADENOMA
CARCINOMA
ADENOMA
ADENOCARCINOMA
ENDIOMETRIAL POLYPS
                                                                               [SLOPE FACTOR]
                                                                   [EPA       ORAL         INHALATION
                                                                   GROUP] (mg/kg/dayr'dng/kg/day)-'
                                                       [UNIT RISK]
                                                    ORAL        INHALATION   REFERENCE
                                                    (ug/L)'1     (ug/cu m)-l
                                                                                                                             010969
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY.
NITROFURAZONE
            ORAL: DIET
                46 WEEKS
                RAT
                          000059-87-0
                                               MAMMARY
            B2
TUMORS
                                                                           1 5E+0
4.3E-5
                                                                                                                             005110
NITROPROPANE.  2-                   000079-46-9
            INHALATION:       22 MONTHS
            INTERMITTENT     RAT                LIVER
                                                                 B2
                                                    TUMORS

INHALATION  [SLOPE] COMMENT:   SEE APPENDIX A-II:  DOSE  CONVERSIONS ON HEAST.
NITROSO-DI-N-BUTYLAMINE.  N-      000924-16-3
            ORAL: DRINKING   LIFETIME
            WATER            MOUSE              BLADDER
                                               ESOPHAGUS
                                                                 IRIS      IRIS
                                                     TUMORS
                                                     TUMORS
                                    9 4E+0
                                     5 4E+0
          2  7E-3
IRIS
IRIS
            INHALATION [SLOPE]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST.
                                                                                                                             010142
                                                                                                                             010143
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                            3-28

-------
                                                           HEAST TABLE 3:   CARCINOGENICITY
CHEMICAL     ROUTE
             EXPERIMENT LENGTH
                 SPECIES
TARGET
                                                                                                                               May 1995
                                                                 CANCER
            [SLOPE  FACTOR]
[EPA      ORAL         INHALATION
GROUP]  (mg/kg/day) '(mg/kg/day)'
    [UNIT RISK]
 ORAL        INHALATION
 (ug/L)'      (ug/cu m)-l
                                                                                                                                            REFERENCE
NITROSO-DI-N-PROPYLAMINE.  N-     000621-64-7
                                                                             IRIS
                                                                          IRIS
                                                                   IRIS
                                                          010147
NITROSO-N-ETHYLUREA.  N-           000759-73-9
            ORAL: DRINKING   203 DAYS
            WATER            RAT               INTESTINE
                                                                B2
                                                    GASTROINTESTINAL
                                                    TUMORS
                                       1  4E+2
             [EPA GROUP] COMMENT:  UNDER REVIEW. CLASSIFICATION  SUBJECT TO CHANGE.
             GENERAL COMMENT:   FOR RCRA ACTIVITIES ONLY.  CONTACT THE HEALTH ASSESSMENT SECTION (202)  382-4761 FOR RCRA-APPROVED
                       NUMERIC ASSESSMENT FOR THIS COMPOUND.  UNDER REVIEW.
NITROSO-N-METHYLUREA.  N-          000684-93-5
            ORAL: GAVAGE     308 DAYS
                             GUINEA PIG        PANCREAS
                                                                B2
                                                    ADENOCARCINOMA
            [EPA GROUP] COMMENT:  UNDER REVIEW. CLASSIFICATION  SUBJECT TO CHANGE.
            GENERAL COMMENT:  THE CRAVE WORK GROUP (04/01/92) STATES THERE IS NO ACCEPTABLE QUANTITATION FOR NITROSO-N-METHYLUREA. N-
                                                          010426
                                                                                         010427
NITROSODIETHANOLAMINE. N-
                         001116-54-7
NITROSODIETHYLAMINE,  N-           000055-18-5
            ORAL: DRINKING   6 OR 12 MONTHS
            WATER           RAT               LIVER
                                                                             IRIS
                                                                 IRIS
                                                                          IRIS
                                       IRIS
                      1 5E+2
                                                                   IRIS
IRIS
IRIS
                                                    TUMORS

INHALATION [SLOPE]-COMMENT;  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.

                         000062-75-9
NITROSODIMETHYLAMINE.  N-
            ORAL:  DRINKING
            WATER            RAT               LIVER             TUMORS
                                                                IRIS
                                       IRIS
                      5.1E+1
IRIS
IRIS
                                                          010144
010145
010146
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                           3-29

-------
                                                           HEAST TABLE 3:   CARCINOGEN1CITY
                                                                                                                  Hay 1995
CHEMICAL
EXPERIMENT LENGTH
    SPECIES
            [SLOPE  FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
ROUTE            SPECIES            TARGET            CANCER

INHALATION  [SLOPE] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS  ON HEAST.
                                                                                                                      [UNIT RISK]
                                                                                                                   ORAL        INHALATION    REFERENCE
                                                                                                                   (ug/L)'1     (ug/cu m)-l
NITROSODIPHENYLAMINE.  N-
             000086-30-6
                                                                            IRIS
                                                              IRIS
                                                                                                                   IRIS
                                                                                                                005112
NITROSOMETHYLETHYLAMINE, N-      010595-95-6
                                                                             IRIS      IRIS
                                                                                          IRIS
                                                                                                                                        010148
NITROSOMETHYLVINYLAMINE, N
            INHALATION
                            RAT
            ORAL:  DRINKING
            WATER
             004549-40-0
                                                    82
                      UPPER RESPIRATORY  CARCINOMAS
                      TRACT
                      UPPER DIGESTIVE    CARCINOMAS
                      TRACT
                                                                                                                010149
NITROSOPYRROLIDINE.  N-            000930-55-2
            ORAL:  DIET      LIFETIME
                            RAT               LIVER
                                                    IRIS      IRIS
                                        TUMORS
                      2 1E+0
                                                                                          IRIS      IRIS
            INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II.  DOSE CONVERSIONS ON HEAST.
PARATHION
             000056-38-2
                                                                             IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXIC1TY  (OTHER THAN CARCINOGENICITY)
                                                          010300
                                                                                                                                         005116
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK INFORMATION HOTLINE.  (513) 569-7254.
                                                                                                                               3-30

-------
                                                           HEAST TABLE 3:   CARCINOGENICITY
CHEMICAL    ROUTE
EXPERIMENT LENGTH
    SPECIES
TARGET            CANCER

      000087-84-3
PENTABROMO-6-CHLOROCYCLOHEXANE.  1.2.3.4.5-
            ORAL: DIET      2 YEARS
                            RAT               INTESTINE.  LARGE   TUMORS

            ORAL [SLOPE] COMMENT:  BASED ON RESULTS WITH THE ALPHA ISOMER.
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)-'
                                                             2.3E-2
                       May 1995

   [UNIT  RISK]
ORAL        INHALATION   REFERENCE
(ug/L)'1     (ug/cu m)-l
                                                                    6.6E-7
                                                          010150
PENTACHLORONITROBENZENE           000082-68-8
            ORAL            72 WEEKS
                            MOUSE             LIVER
                                       TUMORS
                                                             2 6E-1
            ORAL [SLOPE]  COMMENT:  UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
                                                                    7.4E-6
                                                          010151
PENTACHLOROPHENOL                  000087-86-5
                                                                             IRIS      IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
                                                                                          IRIS
                                                                                          010381
PHENYLENEDIAMINE. 0-
            ORAL:  DIET
    548 DAYS
    RAT
             000095-54-5
                                              LIVER
                                                                             82
                                       4.7E-2
                 TUMORS
            ORAL [SLOPE]  COMMENT:  BASED ON  LIVER TUMORS IN RATS  TREATED WITH 0-PHENYLENEDIAMINE DIHYDROCHLORIDE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC  AND CHRONIC TOXICITY.
                                    1 3E-6
                     010152
PHENYLPHENOL. 2-
            ORAL:  DIET
             000090-43-7
   637 DAYS
   RAT
                                                                                       1 94E-3
                                              URINARY BLADDER   TUMORS
                                                                    5.5E-8
                                                          010153
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER  INFORMATION: RISK INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                               3-31

-------
                                                           HEAST TABLE 3:   CARCINOGEN1CITY
                                                                                                                   Hay 1995
CHEMICAL     ROUTE
EXPERIMENT LENGTH
    SPECIES
POLYBROMINATED  BIPHENYLS
            ORAL:  GAVAGE     25 WEEKS
                            RAT
 TARGET
                      LIVER
                      LIVER
 CANCER
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) Hmg/kg/day)'
                              B2
                  CARCINOMA
                  NEOPLASTIC NODULE
                                                              8.9E+0
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
POLYCHLORINATED BIPHENYLS


PROPYLENE  OXIDE
             001336-36-3


             000075-56-9
            INHALATION:
            INTERMITTENT
    2 YEARS
    MOUSE
                               IRIS


                               IRIS

                               IRIS
                      IRIS
                                                                                       IRIS
                                                                                                     1 3E-2
NASAL CAVITY
TUMORS
            INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II.  DOSE  CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
   [UNIT RISK]
ORAL        INHALATION    REFERENCE
(ug/L)' "   (ug/cu m)-l
                                                   2.5E-4
                                     IRIS
                                                                                           IRIS
                                                                                                    IRIS
                                                                                           010154
                     005118


                     010156

                     010155
QUINOLINE                            000091-22-5
            ORAL:  DIET      20-40 WEEKS
                            RAT                LIVER
                                                              1.2E+1
                                        TUMORS
                                                                     3.5E-4
                                                                         010158
RDX / (CYCLONITE)                  000121-82-4
                                                                             IRIS      IRIS
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                           IRIS
                                                                                           010157
SELENIUM  SULFIDE
             007446-34-6
                                                                             IRIS
            ORAL [SLOPE]  COMMENT:  STUDY RESULTS WERE CONSIDERED INCONCLUSIVE FOR QUANTITATIVE RISK ASSESSMENT.
                                                                                                                 010194
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                               3-32

-------
CHEMICAL

SIHAZINE
                                                            HEAST  TABLE  3:   CARCINOGEN1CITY
ROUTE
            ORAL: DIET
EXPERIMENT LENGTH
    SPECIES
                 2 YEARS
                 RAT
          TARGET

000122-34-9

         MAMMARY
CANCER
                                                                  CARCINOMA
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) '(mg/kg/day) >
                                                               1.2E-1
            ORAL [SLOPE] COMMENT:   UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE  HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                        Hay 1995

   [UNIT RISK]
ORAL        INHALATION    REFERENCE
(ug/L)'1     (ug/cu m)-l
                                                   3.4E-6
                                                           010195
SODIUM DIETHYLDITHIOCARBAMATE   000148-18-5
            ORAL: DIET       77 WEEKS
                             MOUSE             LIVER
                                                                            2 7E-1
                                                     TUMORS

GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                            7.7E-6
                                                                                                     005126
STYRENE                              000100-42-5

            GENERAL COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
                       ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TCDD. 2.3.7.8-
            ORAL: DIET
                          001746-01-6
                 720  DAYS

                 RAT
                                                     B2
                                                  1  5E+5
                                    1.5E+5
                                               RESPIRATORY
                                               SYSTEM
                                               LIVER
                                        TUMORS

                                        TUMORS
                                     4.5E+0
         3 3E-5
         (PG/CU M)-l
                                                                                                                                010480
005128
            ORAL [SLOPE] COMMENT:   UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
            INHALATION [SLOPE] COMMENT:  SEE APPENDIX A-II:  DOSE CONVERSIONS ON HEAST
            INHALATION [UNIT RISK]  COMMENT:  UNDER REVIEW.  NUMBER SUBJECT TO CHANGE  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
                       AN ABSORPTION FACTOR OF 75* IS USED TO CALCULATE THE UNIT RISK FROM THE SLOPE FACTOR.
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK.  INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                               3-33

-------
                                              HEAST TABLE 3:   CARCINOGENICITY
                                                                                                                                          Hay 1995
CHEMICAL     ROUTE
            EXPERIMENT LENGTH
                SPECIES
              [SLOPE FACTOR]               [UNIT RISK]
  [EPA       ORAL         INHALATION      ORAL        INHALATION    REFERENCE
  GROUP] (mg/kg/day) Hmg/kg/day)'        (ug/L)'     (ug/cu m)-l
                                   TARGET            CANCER

                         000630-20-6

                                  LIVER             TUMOR

INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
TETRACHLOROETHANE. 1.1.1.2-
            ORAL:  GAVAGE     103 WEEKS
                                                                            IRIS
                                                                          IRIS
                       2.6E-2
                                                                                                                  IRIS
                                      IRIS
                                                                                                                            010302
TETRACHLOROETHANE. 1.1.2.2-      000079-34-5
            ORAL:  GAVAGE     75 WEEKS
                            MOUSE             LIVER
                                                                IRIS
         IRIS
              2 OE-1
                                                                                                      IRIS
                                                    CARCINOMA

INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
                                                                                                                IRIS
                                                            005130
TETRACHLOROETHYLENE
                         000127-18-4
            GENERAL COMMENT:  CONTACT THE  SUPERFUND HEALTH RISK TECHNICAL  SUPPORT CENTER:  (513) 569-7300
                      ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                                        010482
TETRACHLOROTOLUENE. PARA. ALPHA.  ALPHA.  ALPHA-
            ORAL:  GAVAGE     17.5 WEEKS
                            MOUSE             LUNG
                                                005216-25-1
                                                                B2        2  OE+1
                                                    ADENOCARCINOMA
                                      5.7E-4
                                                  005028
TETRACHLOROVINPHOS /  (STIROFOS)     000961-11-5
            ORAL:  DIET       560 DAYS
                            MOUSE             LIVER
                                                    TUMORS
                                                                          2 4E-2
            [EPA GROUP] COMMENT:  UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TOLUENE-2.4-DIAMINE
            ORAL:  DIET
                         000095-80-7
                84-103 WEEKS
                RAT               MAMMARY
B2
3 2E+0
                                                                TUMORS
                                      6.9E-7
                                                                                                      9.1E-5
                                                                                                                            010159
                                                            010160
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION  RISK INFORMATION HOTLINE: (513) 569-7254.
                                                                                                                                          3-34

-------
                                                           HEAST TABLE 3:   CARCINOGENICITY
CHEMICAL    ROUTE

TOLUIDINE.  P-
            ORAL: DIET
                         EXPERIMENT LENGTH
                             SPECIES
                            18 MONTHS
                            MOUSE
          TARGET

000106-49-0

         LIVER
CANCER
                                                                TUMORS
            [SLOPE FACTOR]
[EPA      ORAL         INHALATION
GROUP] (mg/kg/day) Hmg/kg/day)'1
                     1.9E-1
                        Nay 1995

    [UNIT RISK]
 ORAL        INHALATION   REFERENCE
 (ug/L)'     (ug/cu m)-l
                                    5.4E-6
                      010162
TOXAPHENE
                                     008001-35-2
            ORAL: DIET
                            18 MONTHS
                            MOUSE
                                       IRIS
                                              LIVER
                           TUMORS
            INHALATION [SLOPE] COMMENT:   SEE APPENDIX A-II. DOSE CONVERSIONS ON  HEAST.
            INHALATION [UNIT RISK] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
                     IRIS
                      1.1E+0
IRIS
IRIS
005134
TRICHLOROANILINE HYDROCHLORIDE. 2.4.6-
            ORAL:  DIET       18 MONTHS
                            MOUSE
                                                               033663-50-2
                                              VASCULAR SYSTEM    TUMORS
                                                                                      2.9E-2
                                                                             8.2E-7
                                                                        005142
TRICHLOROANILINE. 2.4.6-         000634-93-5
            ORAL: DIET       18 MONTHS
                            MOUSE             VASCULAR SYSTEM
                                                                TUMORS
                                                                                      3 4E-2
                                                                             1E-6
                                                                        010487
TRICHLOROETHANE.  1.1.2-          000079-00-5
            ORAL:  GAVAGE     78 WEEKS
                            MOUSE             LIVER
                                                                             IRIS
                                                                CARCINOMA
                                                 IRIS
                                    5.7E-2
                                     IRIS
          IRIS
            INHALATION  [SLOPE] COMMENT:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II; DOSE  CONVERSIONS ON HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
            005144
TRICHLOROETHYLENE                 000079-01-6

            GENERAL COMMENT:  CONTACT THE SUPERFUND HEALTH  RISK TECHNICAL SUPPORT CENTER  (513) 569-7300.
                                                                                                                                         010483
IRIS.  EPA'S  INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY.  FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                                        3-35

-------
                                                           HEAST TABLE  3:   CARCINOGENICITY
                                                                                                                   May 19%
CHEMICAL    ROUTE
EXPERIMENT LENGTH
    SPECIES
TRICHLOROPHENOL.  2.4.6-
            ORAL:  DIET       107 WEEKS
                             MOUSE
                                               TARGET

                                     000088-06-2

                                              BLOOD
                                                                 CANCER
                                        LEUKEMIA
            [SLOPE FACTOR]                [UNIT RISK]
[EPA      ORAL         INHALATION      ORAL        INHALATION   REFERENCE
GROUP] (mg/kg/dayr'dng/kg/day)-1        (ug/L) '     (ug/cu m)-l
                                                     IRIS
        IRIS
1E-2
                                                                                           IRIS
                                              IRIS
            INHALATION [SLOPE] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX  A-II. DOSE CONVERSIONS ON  HEAST.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY).
TRICHLOROPROPANE. 1,2.3-
            ORAL: GAVAGE
                             RAT
             000096-18-4

                      MULTIPLE SITES
                                                                             B2       7E+0
                                                                TUMORS.
                                                                BENIGN/MALIGNANT.
                                                                COMBINED
            [EPA GROUP] COMMENT:  UNDER REVIEW.  CLASSIFICATION SUBJECT TO CHANGE.
            GENERAL COMMENT:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
                                     2E-4
                                    010428
                                                                                                                                         010849
TRIFLURALIN                         001582-09-8
                                                                             IRIS      IRIS                         IRIS
            GENERAL COMMENT:   ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                 010163
TRIMETHYL PHOSPHATE
            ORAL: GAVAGE
             000512-56-1
    103 WEEKS
    MOUSE
                                                     B2
                                                                                       3.7E-2
                                               UTERUS
                                                                TUMORS
                                                                                           1.1E-6
                                                                                                                                          010164
TRINITROTOLUENE.  2.4.6-           000118-96-7
                                                                             IRIS      IRIS
            GENERAL  COMMENT-  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY).
                                                                                                                    IRIS
                                                                                                                 010476
 IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM.  IS UPDATED MONTHLY. FURTHER INFORMATION:  RISK  INFORMATION HOTLINE:  (513) 569-7254.
                                                                                                                                3-36

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                                                              HEAST TABLE 3:   CARCINOGEN1CITY                                              May 1995

                                                                                              [SLOPE FACTOR]                [UNIT  RISK]
                          EXPERIMENT LENGTH                                        [EPA      ORAL         INHALATION     ORAL         INHALATION    REFERENCE
CHEMICAL     ROUTE             SPECIES          >  TARGET             CANCER        GROUP] (mg/kg/day) '(nig/kg/day)'       (ug/L)'1     (ug/cu m)-l

VINYL CHLORIDE                      000075-01-4
             ORAL: DIET        1001 DAYS                                          A         1.9E+0                       5.4E-5                 010368
                              RAT                LUNG               TUMORS
                                                LIVER              TUMORS

             ORAL [SLOPE]  COMMENT:  UNDER REVIEW.  NUMBER SUBJECT TO CHANGE.


             INHALATION:       1 YEAR                                             A                        3  OE-1                    8.4E-5       010367
             INTERMITTENT      RAT                LIVER              TUMORS

             INHALATION  [SLOPE] COMMENT:  SEE APPENDIX A-II:  DOSE CONVERSIONS ON HEAST.
             INHALATION  [UNIT  RISK] COMMENT:  UNDER REVIEW.  NUMBER SUBJECT TO CHANGE.
             GENERAL COMMENT:  THE MOST RECENTLY REVIEWED QUANTITATIVE TOXICITY VALUES LISTED HERE APPEAR IN EPA DOCUMENTS  PUBLISHED IN 1984 AND 1985. USE OF
                          THESE VALUES ON AN INTERIM BASIS WAS VALIDATED BY CRAVE (04/05/90)  THE AGENCY IS  AWARE  THAT THESE VALUES DO NOT INCORPORATE CONSIDERABLE
                          INFORMATION THAT IS NOW AVAILABLE.  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT'S POSITION IS THAT THESE TOXICITY VALUES DO NOT
                          REFLECT STATE-OF-THE-ART SCIENCE FOR VINYL CHLORIDE.  EPA NOW HAS INDIVIDUAL  ANIMAL DATA.  NOT AVAILABLE WHEN THE  ORAL UNIT RISK WAS
                          CALCULATED. THAT MAY INFLUENCE THIS VALUE. ADDITIONAL INFORMATION THAT MAY BE FACTORED  INTO A REVISED QUANTITATIVE TOXICITY VALUE
                          INCLUDES DATA ON INCREASED SENSITIVITY OBSERVED  IN YOUNG ANIMALS AND DATA ON METABOLISM/PHARMACOKINETICS. A UNIT RISK FOR AIR THAT
                          CONSIDERS INFORMATION ON YOUNG AGE EXPOSURE INCREASES THE RISK (I.E .  LOWERS THE RISK SPECIFIC DOSE)  BY AT LEAST 3-FOLD.  THE
                          CONSIDERATION OF METABOLISM PHARMACOKINETICS WILL FURTHER INCREASE THE RISK   ONE UNPUBLISHED PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL
                          PREDICTION RESULTS IN A 100-FOLD INCREASED RISK.
IRIS.  ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.                             3-37

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                                                    REFERENCES FOR  HEAST TABLE 3:   CARCINOGENICITY                                    May 1995


ACEPHATE                                                     030560-19-1
        010086  CHEVRON CHEMICAL COMPANY.  1982. MRIO NO 00105197. AVAILABLE FROM EPA.  WRITE  TO  FOI. EPA. WASHINGTON. DC 20460.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACEPHATE.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE  OF  SOLID WASTE. WASHINGTON, DC.

                US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP.

ACROLEIN                                                     000107-02-8
        005001  US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACROLEIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE. WASHINGTON DC.

                US EPA. 1992. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP.

ACRYLAHIDE                                                  000079-06-1
        010087  JOHNSON K. S GORZINSKI. KM BODNER. ET AL.  1986. CHRONIC TOXICITY AND ONCOGENICITY STUDY ON ACRYLAMIDE  INCORPORATED IN THE DRINKING  WATER
                OF FISCHER 344 RATS. DOW CHEMICAL. USA. MIDLAND. MI.

                US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACRYLAMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF  SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP.
                                                                                                                                                   R3-1

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                                                     REFERENCES FOR HEAST TABLE  3:   CARCINOGEN1CITY                                    May 1995




ACRYLONITRILE                                               000107-13-1
         005004   BIO/DYNAMICS.  INC.  1980. A 24-MONTH  ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED IN DRINKING WATER TO FISCHER 344
                 RATS.  FINAL REPORT.  VOL 1-4.  PREPARED BY BIO/DYNAMICS. INC.. DIVISION OF BIOLOGY AND SAFETY EVALUATION  EAST MILLSTONE  NJ  UNDER PROJECT
                 NO 77-1744 (BDN-77-27)  FOR MONSANTO  COMPANY. ST LOUIS. MO

                 BIO/DYNAMICS.  INC.  1980. A 24-MONTH  ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED TO SPARTAN RATS IN THE DRINKING
                 WATER.  FINAL REPORT.  VOL 1 AND  2.  PREPARED BY BIO/DYNAMICS. INC..  DIVISION OF BIOLOGY AND SAFETY EVALUATION  EAST MILLSTONE  NJ  UNDER
                 PROJECT NO 77-1745  FOR  MONSANTO COMPANY. ST LOUIS. MO.

                 QUAST.  JF.  CE WADE.  CG  HUMISTON ET AL.  1980. A 2-YEAR TOXICITY AND ONCOGENICITY STUDY WITH ACRYLONITRILE INCORPORATED IN THE DRINKING
                 WATER  OF RATS.  PREPARED BY THE  TOXICOLOGY RESEARCH LABORATORY. HEALTH AND ENVIRONMENTAL RESEARCH.  DOW CHEMICAL USA  MIDLAND  MI FOR THE
                 CHEMICAL MANUFACTURERS  ASSOCIATION.  WASHINGTON. DC.

                 US EPA.  1983.  HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

                 US EPA.  1987.  HEALTH EFFECTS  ASSESSMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

                 US EPA.  1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

         005003   O'BERG.  M.  1980.  EPIDEMIOLOGIC  STUDY OF WORKERS EXPOSED TO ACRYLONITRILE.  J OCCUP MED.  22:  245-252.

                 US EPA.  1983.  HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

                 US EPA.  1987.  HEALTH EFFECTS  ASSESSMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.  WASHINGTON DC

                 US EPA.  1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                     R3-2

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                                                    REFERENCES FOR HEAST TABLE  3:   CARCINOGENICITY                                    Hay 1995
ALACHLOR                                                     015972-60-8
         010180   STOUT.  LO.  ET AL. 1983. A CHRONIC STUDY OF ALACHLOR ADMINISTERED  IN FEED TO LONG-EVANS RATS. EHL #800218. PROJECT NO.  ML-80-186.  REPORT
                 MSL-3282/3284. VOL.  I AND II. UNPUBLISHED STUDY RECEIVED FEB. 28.  1984 UNDER U.S. EPA REG. NO. 524-316. PREPARED BY MONSANTO
                 ENVIRONMENTAL HEALTH LABORATORY (EHL).  SUBMITTED BY MONSANTO CO..  WASHINGTON. DC. CDL.252496-7.

                 US EPA  1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR ALACHLOR.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR  THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA  1992 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  ALACHLOR  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR  THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA.  1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.

ALDRIN                                                        000309-00-2
         005006   EPSTEIN.  SS. 1975. THE CARCINOGENICITY OF DIELDRIN.  PART I.  SCI TOTAL ENVIRON. 4: 1-52

                 NCI (NATIONAL CANCER INSTITUTE). 1977. BIOASSAYS OF  ALDRIN AND  DIELDRIN  FOR POSSIBLE CARCINOGENICITY   NCI CARCINOGENESIS TECH REP SER NO
                 21. NCI-C6-TR-66 DHEW PUBLICATION NO. (NIH) 78-821.

                 DAVIS.  KJ.  AND OG FITZHUGH.  1962. TUMORIGENIC POTENTIAL OF ALDRIN AND DIELDRIN FOR  MICE.  TOXICOL APPL  PHARMACOL.  4: 187-189

                 DAVIS.  KJ.  1965.  PATHOLOGY REPORT ON MICE FOR ALDRIN. DIELDRIN. HEPTACHLOR. OR HEPTACHLOR EPOXIDE  FOR  TWO YEARS   INT FOOD DRUG ADMIN.

                 US EPA.  1986. CARCINOGENICITY ASSESSMENT OF ALDRIN AND DIELDRIN.  PREPARED BY  THE OFFICE  OF HEALTH  AND  ENVIRONMENTAL ASSESSMENT.
                 CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC

                 US EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP

ALLYL CHLORIDE                                              000107-05-1
         010181   US EPA  1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES  PREPARED BY  THE OFFICE  OF HEALTH  AND  ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.' OH FOR THE OFFICE  OF  SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP
                                                                                                                                                     R3-3

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCIMOGEN1CITY                                    Hay 1995



ANILINE                                                       000062-53-3
        010088   CUT  (CHEMICAL  INDUSTRY INSTITUTE OF TOXICOLOGY). 1982. 104-WEEK CHRONIC TOXICITY STUDY IN RATS:  ANILINE  HYDROCHLORIDE. FINAL REPORT.

                 US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ANILINE. PREPARED BY THE OFFICE OF  HEALTH AND  ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE. WASHINGTON. DC.

                 US  EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

ARAMITE                                                       000140-57-8
        010206   OSER  BL. AND M  OSER. 1962. 2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE).  II.  CARCINOGENICITY. TOXICOL APPL PHARMACOL.
                 4:  70-88.

                 POPPER H. SS STEINBERG. BL OSER. AND M OSER.  1960. THE CARCINOGENIC EFFECT OF ARAMITE IN RATS.  CANCER.  13(5):  1035-1046.

                 US  EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR ARAMITE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US  EPA.  1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                   R3-4

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                                                    REFERENCES  FOR  HEAST TABLE 3:   CARCINOGENICITY                                    May 1995
ARSENIC.  INORGANIC                                         007440-38-2
         005007   BROWN.  CC AND KC CHU.  1983. APPROACHES TO EPIDEMIOLOGIC ANALYSIS OF PROSPECTIVE AND RETROSPECTIVE STUDIES:  EXAMPLE OF LUNG CANCER AND
                 EXPOSURE TO ARSENIC.  IN: RISK ASSESSMENT: PROC SIMS CONFERENCE ON ENVIRONMENTAL EPIDEMIOLOGY.  JUNE 28-JULY  2.  1982. ALTA UT. SIAM
                 PUBLICATION.

                 BROWN.  CC AND KC CHU.  1983. IMPLICATIONS OF THE MULTISTAGE THEORY OF CARCINOGENESIS APPLIED TO OCCUPATIONAL ARSENIC EXPOSURE  J NAT
                 CANCER INST.  70: 455-463.

                 LEE-FELDSTEIN.  A.  1983. ARSENIC AND RESPIRATORY CANCER IN MAN: FOLLOW-UP OF AN OCCUPATIONAL STUDY. IN:  ARSENIC:  INDUSTRIAL. BIOMEDICAL.
                 AND ENVIRONMENTAL PERSPECTIVES. W LEDERER AND R FENSTERHEIM. EDS. VAN NOSTRAND REINHOLD.  NEW YORK.

                 BROWN.  CC AND KC CHU.  1983. A NEW METHOD FOR THE ANALYSIS OF COHORT STUDIES. IMPLICATIONS OF THE MULTISTAGE THEORY OF CARCINOGENESIS
                 APPLIED TO OCCUPATIONAL ARSENIC EXPOSURE. ENVIRON HEALTH PERSP. 50: 293-308

                 HIGGINS. I. 1982.  ARSENIC  AND RESPIRATORY CANCER AMONG A SAMPLE OF ANACONDA SMELTER WORKERS. REPORT SUBMITTED TO THE OCCUPATIONAL  SAFETY
                 HEALTH ADMINISTRATION IN THE COMMENTS OF THE KENNECOTT MINERALS ON THE INORGANIC ARSENIC RULE MAKING. EXHIBIT 203-5.

                 ENTERLINE. PE AND GM MARSH. 1982. CANCER AMONG WORKERS EXPOSED TO ARSENIC AND OTHER SUBSTANCES IN A COPPER SMELTER. AM  J  EPIDEMIOL.  116:
                 895-911.

                 US EPA  1984. HEALTH EFFECTS ASSESSMENT  FOR ARSENIC. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON DC.

                 US EPA. 1980. HEALTH ASSESSMENT DOCUMENT FOR  INORGANIC ARSENIC.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE  PARK. NC

                 US EPA. 1988. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.

         010925  TSENG WP.  1977. EFFECTS AND DOSE  RESPONSE RELATIONSHIPS OF  SKIN  CANCER AND BLACKFOOT DISEASE WITH ARSENIC. ENVIRON HEALTH PERSPECT.  19:
                 108-119.

                 US EPA. 1989. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.
                                                                                                                                                      R3-5

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                                                     REFERENCES FOR  HEAST TABLE 3:   CARCINOGEN1CITY                                    Hay 1995




ASBESTOS                                                     001332-21-4
         005010  NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY AND CARCINOGENESIS  STUDIES OF  CHRYSOTILE ASBESTOS (CAS NO 1200-29-5) IN F344/N RATS
                 (FEED STUDIES).  TECHNICAL REPORT SERIES NO 295.

                 US EPA.  1988.  DRINKING WATER CRITERIA DOCUMENT FOR ASBESTOS.  PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON. DC.

                 US EPA.  1988.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP.

         005919  US EPA.  1986.  AIRBORNE ASBESTOS HEALTH ASSESSMENT UPDATE.  PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE  RESEARCH TRIANGLE
                 PARK.  NC.  EPA 600/8-84/003F.

                 US EPA.  1988.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP

ATRAZINE                                                     001912-24-9
         010380  GIBA-GEIGY.  1986.  TWO-YEAR FEEDING STUDY IN THE RAT.  CONDUCTED BY AMERICAN BIOGENICS CORP. MRID NO 262714-262727  AVAILABLE FROM EPA
                 WRITE  TO FOI,  EPA.  WASHINGTON. DC 20460.

                 US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR ATRAZINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA.  1990.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP

AZOBENZENE                                                   000103-33-3
         010089  NCI  (NATIONAL  CANCER INSTITUTE). 1979.  BIOASSAY OF AZOBENZENE  FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECHNICAL REPORT SERIES
                 NO.  154. US  DHEW PUBL  NO.  (NIH) 79-1710. P 112.

                 US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR AZOBENZENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA.  1988.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP.
                                                                                                                                                    R3-6

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                                                    REFERENCES  FOR HEAST  TABLE 3:   CARCINOGEN1CITY                                    Hay 1995
BENZENE                                                       000071-43-2
        005011   WONG.  0.  RW MORGAN AND MO WHORTON.  1983.  COMMENTS ON THE  NIOSH STUDY OF LEUKEMIA  IN BENZENE WORKERS. TECHNICAL REPORT SUBMITTED TO GULF
                 CANADA.  LTD.  BY  ENVIRONMENTAL HEALTH ASSOCIATES.  AUGUST 31.  CITED IN US EPA.  1985

                 OTT. MG.  JC TOWNSEND. WA FISHBECK AND RA LANGNER. 1978. MORTALITY AMONG WORKERS OCCUPATIONALLY EXPOSED TO BENZENE. ARCH ENVIRON HEALTH.
                 33:  3-10.

                 RINSKY.  RA. RJ YOUNG AND AB SMITH.  1981.  LEUKEMIA IN BENZENE WORKERS. AM  J  IND MED  2: 217-245.

                 US EPA.  1987. MEMORANDUM FROM J. ORME HEB.  CSD/ODW TO C.  VOGT. JUNE. 1987.  CRITERIA AND STANDARDS DIVISION. ODW.

                 US EPA  1985   INTERIM QUANTITATIVE CANCER UNIT RISK ESTIMATES DUE TO INHALATION OF BENZENE  OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. CARCINOGEN ASSESSMENT GROUP.  WASHINGTON. DC.  OFFICE OF AIR QUALITY PLANNING AND STANDARDS. WASHINGTON. DC.

                 US EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BENZIDINE                                                    000092-87-5
        005014   ZAVON. MR. U  HOEGG AND E BINGHAM. 1973. BENZIDINE EXPOSURE AS A CAUSE OF  BLADDER  TUMORS.  ARCH  ENVIRON HEALTH. 27: 1-73.

                 US EPA  1986  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZIDINE  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA  1980  AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR BENZIDINE. PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER  REGULATIONS AND STANDARDS. WASHINGTON. DC.

                 US EPA  1987  HEALTH EFFECTS ASSESSMENT FOR BENZIDINE. PREPARED BY THE  OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                 CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA.  1986.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP

BENZOTRICHLORIDE                                           000098-07-7
        010092   FUKUDA K. H METSUSHITA AND K TAKEMOTO. 1978. CARCINOGENICITY OF BENZOTRICHLORIDE  BY  THE ORAL  ROUTE  OF ADMINISTRATION (J-4774).  IN:  PROC
                 52ND ANN MEET JAPANESE  INDUSTRIAL HEALTH ASSOC.  TSCA 8E SUBMISSION DOCUMENT NO 88-8000360.  FICHE #204867.  P  516-517.

                 US EPA  1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZOTRICHLORIDE  PREPARED BY  THE  OFFICE OF  HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA.  1989.  CARCINOGEN RISK ASSESSMENT VERIFICATION  ENDEAVOR (CRAVE)  WORK GROUP.


                                                                                                                                                     R3-7

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                                                   REFERENCES FOR HEAST TABLE 3:   CARCINOGEN1CITY                                   May 1995



BENZO[A]ANTHRACENE                                         000056-55-3
         010182  REFER TO IRIS.

                US EPA. 1990. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP.

BENZO[A]PYRENE                                              000050-32-8
         010508  NEAL J. RH RIGDON.  1967.  GASTRIC TUMORS IN MICE FED BENZO[A]PYRENE.  A QUANTITATIVE STUDY  TEX REP BIOL MED. 25: 553

                US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT  FOR POLYCYCLIC AROMATIC  HYDROCARBONS  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. FOR  THE OFFICE OF WATER.  WASHINGTON. DC.

                US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT  FOR POLYCYCLIC AROMATIC  HYDROCARBONS  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.

BENZO[B]FLUORANTHENE                                      000205-99-2
         010183  REFER TO IRIS.

                US EPA. 1990. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP

BENZO[K]FLUORANTHENE                                      000207-08-9
         010090  REFER TO IRIS.

                US EPA. 1990. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP.

BENZYL  CHLORIDE                                            000100-44-7
         010093  LIJINSKI W. 1986. CHRONIC BIOASSAY OF  BENZYL CHLORIDE IN F344 RATS AND  (C57BL/6J X BALB/OF1  MICE.  J  NATL CANCER INST. 76.  1231-1236.

                US EPA. 1986. HEALTH AND  ENVIRONMENTAL EFFECTS  PROFILE FOR BENZYL  CHLORIDE. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

                US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP
                                                                                                                                                 R3-8

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                    Hay 1995
BERYLLIUM                                                   007440-41-7
         005018   SCHROEDER. HA AND M MITCHNER.  1975.  LIFE-TIME STUDIES IN RATS: EFFECTS OF ALUMINUM.  BARIUM.  BERYLLIUM AND TUNGSTEN. J NUTR. 105: 421-427

                 US  EPA.  1991. DRINKING MATER CRITERIA DOCUMENT FOR BERYLLIUM. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER.  WASHINGTON. DC.

                 US  EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

         005017   WAGONER. JK. PF INFANTE AND DL BAYLISS.  1980. BERYLLIUM: AN ETIOLOGIC AGENT IN THE INDUCTION OF LUNG CANCER.  NONNEOPLASTIC RESPIRATORY
                 DISEASE. AND HEART DISEASE AMONG INDUSTRIALLY EXPOSED WORKERS. ENVIRON RES  21: 15-34.

                 US  EPA.  1987. HEALTH ASSESSMENT DOCUMENT FOR BERYLLIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  RESEARCH TRIANGLE PARK. NC.

                 US  EPA.  1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

BIS(2-CHLOROETHYL)  ETHER                                 000111-44-4
         005076   INNES. JRM. BM ULLAND. MG VALERIO ET AL.  1969. BIOASSAY OF PESTICIDES AND INDUSTRIAL CHEMICALS FOR  TUMORIGENICITY  IN MICE: A PRELIMINARY
                 NOTE. J  NATL CANCER INST. 42:  1101-1114.

                 US  EPA.  1987. HEALTH EFFECTS ASSESSMENT  FOR BIS(2-CHLOROETHYL)ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US  EPA.  1980. AMBIENT WATER QUALITY  CRITERIA DOCUMENT FOR CHLOROALKYL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS  AND STANDARDS. WASHINGTON.
                 DC.

                 US  EPA.  1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

BIS(2-CHLORO-1-METHYLETHYL)  ETHER                            000108-06-1
         005079   NTP (NATIONAL TOXICOLOGY PROGRAM). 1982.  CARCINOGENIC BIOASSAY OF BIS(2-CHLORO-1-METHYLETHYL) ETHER (70*) CONTAINING
                 2-CHLORO-l-METHYLETHYL(2-CHLOROPROPYL) ETHER (30X) IN B6C3F1 MICE (GAVAGE STUDY). NCI CARCINOGEN TECH REP SER NO 239   105  P. ALSO  PUBL AS
                 DHHS (NIH) 83-1795

                 US  EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HALOETHERS  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.
                                                                                                                                                    R3-9

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGEN1CITY                                    May 1995



BIS(2-ETHYLHEXYL)  PHTHALATE /  (DEHP)                    000117-81-7
         005120   NTP (NATIONAL TOXICOLOGY PROGRAM).  1982.  CARCINOGENESIS BIOASSAY OF DK2-ETHYLHEXYL)  PHTHALATE  (CAS NO 117-81-7) IN F344 RATS AND  B6C3F1
                 MICE  (FEED  STUDY). NTP TECH REPORT SER NO 217.  NIH/PUB-82-1773.  NTP-80-37.  NTIS PB82-184011.

                 US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR PHTHALIC ACID ALKYL.  ARYL  AND  ALKYL/ARYL ESTERS. PREPARED BY THE OFFICE OF
                 HEALTH AND  ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND
                 EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR  SELECTED PHTHALIC ACID ESTERS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID  WASTE AND  EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US EPA.  1991. DRINKING WATER CRITERIA DOCUMENT  FOR PHTHALIC ACID ESTERS  PREPARED BY  THE  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE
                 OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.

BIS(CHLOROMETHYL)  ETHER                                   000542-88-1
         005077   KUSCHNER. M. S LASKIN. RT DREW. ET AL.  1975.  INHALATION CARCINOGENICITY OF  ALPHA HALO ETHERS: III  LIFETIME AND LIMITED PERIOD INHALATION
                 STUDIES  WITH BIS(CHLOROMETHYL) ETHER  AT 0.1  PPM. ARCH ENVIRON HEALTH  30(2).  73-77

                 US EPA.  1988. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP.

BROMODICHLOROMETHANE                          •            000075-27-4
         005148   NTP (NATIONAL TOXICOLOGY PROGRAM).  1987.  NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMODICHLOROMETHANE (CAS
                 NO 75-27-4) IN F344 RATS AND B6C3F1 MICE  (GAVAGE STUDIES). NTP.  RESEARCH  TRIANGLE PARK. NC  NTP TR 321. US DEPT OF  HEALTH AND HUMAN
                 SERVICES. PUBLIC HEALTH SERVICE.  NATIONAL INSTITUTE OF HEALTH.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR  TRIHALOGENATED METHANES.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE   WASHINGTON  DC
                 ECAO-CIN-H083.

                 US EPA   1992. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP

BROMOETHENE /  (VINYL BROMIDE)                            000593-60-2
         010094   BENYA TJ. WM BASEY. MA DORATO AND PE  BERTEAU 1982  INHALATION CARCINOGENICITY BIOASSAY OF VINYL BROMIDE IN RATS TOXICOL APPL PHARMACOL
                 64: 367-379.

                 US EPA.  1984. HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR BROMOETHENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.
                                                                                                                                                  R3-10

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCINOGENICITY                                    May 1995
BROMOFORM                                                    000075-25-2
        005150  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1988. TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES  OF TRIHALOMETHANE (BROMOFORM) (CAS
                NO 75-25-2) IN F344 RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP-TR 350

                US EPA.  1989. HEALTH AND ENVIRONMENTAL  EFFECTS  DOCUMENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                US EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BUTADIENE. 1.3-                                             000106-99-0
        010477  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1984. TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.3-BUTADIENE (CAS 106-99-0)  IN  B6C3F1 MICE  (INHALATION
                STUDIES).

                US EPA.  1985. MUTAGENICITY AND CARCINOGENICITY  ASSESSMENT OF 1.3-BUTADIENE  OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT. WASHINGTON.
                DC.  EPA  600/8-85-004F. NTIS-PB86-12507.

                US EPA.  1989. HEALTH AND ENVIRONMENTAL  EFFECTS  DOCUMENT FOR  1.3-BUTADIENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC

                US EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

BUTYL BENZYL  PHTHALATE.  N-                                000085-68-7
        005122  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1982. CARCINOGENESIS BIOASSAY OF BUTYLBENZYL PHTHALATE (CAS. NO  85-68-7) IN F344  RATS AND  B6C3F1 MICE
                (FEED STUDY). NTP TECH REP. NTIS PB83-118398. RESEARCH TRIANGLE PARK. NC

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON  DC.

                US EPA.  1991. DRINKING WATER CRITERIA DOCUMENT  FOR  PHTHALIC ACID ESTERS (PAE)S  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF DRINKING WATER.  WASHINGTON.  DC.

                US EPA.  1987. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
                                                                                                                                                   R3-11

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                                                    REFERENCES  FOR HEAST TABLE  3:   CARCINOGENICITY                                   May 1995



CADMIUM                                                      007440-43-9
         005019   THUN.  MJ.  TM SCHNORR. AB SMITH AND WE HALPERIN.  1985. MORTALITY AMONG A COHORT OF US CADMIUM PRODUCTION  WORKERS' AN UPDATE. J NATL CANCER
                 INST.  74(2):  325-333.

                 US EPA.  1985.  UPDATED MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF CADMIUM. ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR CADMIUM.
                 (MAY 1981.  EPA 600/8-81-023) EPA 600/8-83-025F.

                 US EPA.  1986.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

CAPTAFOL                                                     002425-06-1
         010095   US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR CAPTAFOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CAPTAN                                                        000133-06-2
         010184   NCI (NATIONAL CANCER INSTITUTE). 1977. BIOASSAY OF CAPTAN FOR POSSIBLE CARCfNOGENICITY  CAS NO.  133-06-2. NTIS PB-273475

                 CHEVRON.  1982. UNPUBLISHED STUDY.

                 BIODYNAMICS.  1983. SUBMITTED CHEVRON CHEMICAL CORPORATION. UNPUBLISHED STUDY

                 US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR CAPTAN. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA.  1988.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CARBAZOLE                                                    000086-74-8
         010096   TSUDA  H. A HAZIWARA. M SHIBATA. M OHSIMA AND N  ITO.  1982. CARCINOGENIC EFFECT OF CARBAZOLE IN THE  LIVER  OF (C57BL/6N X C3G/HEN)F1 MICE  J
                 NATL CANCER INST. 69: 1383-1389.

                 US EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR CARBAZOLE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
                                                                                                                                                  R3-12

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                                                     REFERENCES  FOR  HEAST TABLE 3:   CARCINOGENICITY                                    May 1995




CARBON  TETRACHLORIDE                                       000056-23-5
         005022  DELIA PORTA.  GB.  B TERRACINI AND KP SHUBIK. 1961.  INDUCTION WITH CARBON TETRACHLORIDE OF LIVER CELL CARCINOMAS IN HAMSTERS.  J NATL CANCER
                 INST. 26:  855-863.

                 EDWARDS. J. WE HESTON AND HA DALTON. 1942. INDUCTION OF THE CARBON TETRACHLORIDE HEPATOMA  IN STRAIN L MICE. J NATL CANCER INST.  3:
                 297-301.

                 NCI  (NATIONAL CANCER INSTITUTE). 1976.  REPORT ON CARCINOGENESIS BIOASSAY  OF  CHLOROFORM. NTIS PB264-018. NCI-CG-TR-3.

                 US EPA.  1984.  HEALTH ASSESSMENT DOCUMENT FOR CARBON TETRACHLORIDE.  PREPARED  BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH.

                 US EPA.  1984.  HEALTH EFFECTS ASSESSMENT FOR CARBON TETRACHLORIDE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE  OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                 US EPA.  1986.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP

CHLORANIL                                                    000118-75-2
         010097  BRL  (BIONETICS RESEARCH LABS. INC.). 1968. EVALUATION OF CARCINOGENIC. TERATOGENIC AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES AND
                 INDUSTRIAL CHEMICALS. VOLUME I: CARCINOGENIC STUDY.  NTIS PB 223159.

                 US EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORANIL  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE  OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHLORDANE                                                    000057-74-9
         005024  VELSICOL.  1973. EIGHTEEN MONTH ORAL CARCINOGENIC STUDY IN MICE.  DECEMBER  14, 1973  MRID NO  00067568. AVAILABLE FROM EPA  WRITE TO FOI
                 EPA.  WASHINGTON.  DC 20460.

                 NCI  (NATIONAL CANCER INSTITUTE). 1977.  BIOASSAY OF CHLORDANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 8  ALSO
                 PUBL  AS DHEW  PUBL NO (NIH) 77-808.

                 US EPA. 1988.  UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLORDANE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE  OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC

                 US EPA. 1986.  CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE  PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL  ASSESSMENT. CARCINOGEN ASSESSMENT GROUP.  WASHINGTON.  DC.

                 US EPA. 1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP
                                                                                                                                                   R3-13

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                                                    REFERENCES FOR  HEAST TABLE 3:   CARCINOGEN1CITY                                    May  1995



CHLORO-2-METHYLANILINE  HYDROCHLORIDE.  4-              003165-93-3
         010419  WEISBURGER EK. AB RUSSFIELD.  F HOMBURGER. ET AL.  1978.  TESTING OF  TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
                TOXICITY OR CARCINOGENICITY.  J ENVIRON PATHOL TOXICOL.  2:  325-356.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-CHLORO-2-METHYLANILINE AND 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE. PREPARED
                BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF
                SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHLORO-2-METHYLANILINE.  4-                               000095-69-2
         010098  WEISBURGER EK. AB RUSSFIELD.  F HOMBURGER. ET AL.  1978.  TESTING OF  TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
                TOXICITY OR CARCINOGENICITY.  J ENVIRON PATHOL TOXICOL.  2:  325-356.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-CHLORO-2-METHYLANILINE AND 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE. PREPARED
                BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF
                SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

CHLOROBENZILATE                                            000510-15-6
         010848  BRL (BIONETICS RESEARCH LABORATORIES). 1968. EVALUATION OF CARCINOGENIC. TERATOGENIC AND MUTAGENIC ACTIVITIES OF SELECTED AND INDUSTRIAL
                CHEMICALS. I. CARCINOGENIC STUDY.  PREPARED FOR NATIONAL CANCER INSTITUTE. REPORT NO  NCI DCCP-C6 1973-1-1.  NTIS PB-223-157  P  17  27-31
                35. 39. 56-57. 68.

                US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROBENZILATE. PREPARED BY THE OFFICE OF HEATH  AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON.  DC.
                                                                                                                                                 R3-14

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                                                     REFERENCES FOR HEAST TABLE  3:  CARCINOGEN1CITY                                     May  1995



 CHLOROFORM                                                  000067-66-3
         005036  JORGENSON. TA. EF MEIERHENRY.  CJ  RUSHBROOK ET AL. 1985. CARCINOGEN1CITY OF CHLOROFORM IN DRINKING WATER TO MALE OSBORNE-MENDEL RATS AND
                 FEMALE B6C3F1 MICE.  FUND APPL  TOXICOL(USA). 5(4): 760-769.

                 US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROFORM.  PREPARED BY  THE OFFICE OF HEALTH  AND  ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA. 1987. CARCINOGEN RISK  ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP

         005035  NCI (NATIONAL CANCER INSTITUTE).  1976. REPORT ON CARCINOGENESIS BIOASSAY OF  CHLOROFORM.  NTIS PB264-018.

                 US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROFORM.  PREPARED BY  THE OFFICE OF HEALTH  AND  ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR CHLOROFORM.  PREPARED BY THE OFFICE OF  HEALTH AND  BENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

                 US EPA. 1987. CARCINOGEN RISK  ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP

CHLOROMETHANE                                               000074-87-3
         005038  CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY).  1981. FINAL REPORT ON 24-MONTH INHALATION  STUDY ON  METHYL CHLORIDE  PREPARED BY
                 BATTELLE-COLUMBUS  LABORATORIES. COLUMBUS.  OH DECEMBER 31.

                 NIOSH (NATIONAL INSTITUTE  FOR  OCCUPATIONAL SAFETY AND HEALTH).  1984.  CARCINOGENIC RISK ASSESSMENT FOR OCCUPATIONAL EXPOSURE TO
                 MONOHALOMETHANES.  NTIS PB85-111623.

                 US EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL CHLORIDE   PREPARED  BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE  OF SOLID  WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.

                 US EPA. 1987.  HEALTH EFFECTS ASSESSMENT FOR CHLOROMETHANE. PREPARED  BY THE OFFICE OF  HEALTH  AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE  OF  EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC

CHLOROMETHYL METHYL ETHER                                000107-30-2
         005081   US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  HALOETHERS  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR  THE OFFICE  OF  SOLID  WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

                 US EPA. 1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP
                                                                                                                                                   R3-15

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                                                    REFERENCES  FOR HEAST TABLE 3:   CARCINOGENICITY                                    May 1995
CHLORONITROBENZENE.  0-                                    000088-73-3
        010099  WEISBURGER EK. AB RUSSFIELD.  F HOMBURGER. ET AL. 1978.  TESTING OF TWENTY-ONE  ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES  FOR LONG-TERM
                TOXICITY OR CARCINOGENICITY.  J ENVIRON PATHOL TOXICOL.  2:  325-356.

                US EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

CHLORONITROBENZENE.  P-                                    000100-00-5
        010100  WEISBURGER EK. AB RUSSFIELD.  F HOMBURGER. ET AL. 1978.  TESTING OF TWENTY-ONE  ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES  FOR LONG-TERM
                TOXICITY OR CARCINOGENICITY.  J ENVIRON PATHOL TOXICOL.  2:  325-356.

                US EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

CHLOROTHALONIL                                             001897-45-6
        010384   IRDC. 1985. TUMORIGENICITY STUDY IN  RATS. CHLOROTHALONIL.  099-5TX-80-234-008.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROTHALONIL  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

CHROMIUM(VI)                                                018540-29-9
        005091  MANCUSO. TF.  1975. INTERNATIONAL CONFERENCE ON HEAVY METALS IN THE ENVIRONMENT. TORONTO. CANADA. OCT 27-31. CITED IN US EPA.  1984.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT  FOR HEXAVALENT CHROMIUM. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE
                OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA  1984. HEALTH ASSESSMENT DOCUMENT FOR CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE US ENVIRONMENTAL PROTECTION AGENCY. RESEARCH TRIANGLE PARK.  NC

                 US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CHRYSENE                                                     000218-01-9
        010185   REFER TO  IRIS.

                 US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                  R3-16

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                                                    REFERENCES  FOR HEAST  TABLE  3:  CARCINOGENICITY                                    May 1995



COKE OVEN EMISSIONS                                       008007-45-2
         005039   MAZUMOAR S. C REDMOND.  W SOLLECITO AND N SUSSMAN  1975.  AN  EPIDEMIOLOG1CAL STUDY OF EXPOSURE TO COAL-TAR-PITCH VOLATILES AMONG COKE OVEN
                 WORKERS. APCAJ. 25(4): 382-389.

                 LAND. CE. 1976. PRESENTATION AT OCCUPATIONAL SAFETY AND  HEALTH ADMINISTRATION HEARINGS ON COKE OVEN STANDARDS.

                 US  EPA. 1984. CARCINOGEN ASSESSMENT OF COKE OVEN EMISSIONS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  CARCINOGEN
                 ASSESSMENT GROUP. WASHINGTON. DC.

                 US  EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CREOSOTE. COAL TAR                                        008001-58-9
         005042   REFER TO IRIS.

                 US  EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

CRESOL,  M- /  (3-METHYLPHENOL)                            000108-39-4
         010187   US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CRESOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US  EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

CRESOL.  0- /  (2-METHYLPHENOL)                            000095-48-7
         010186   US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CRESOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US  EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CRESOL.  P- /  (4-METHYLPHENOL)                            000106-44-5
         010188   US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CRESOLS. PREPARED BY THE OFFICE OF HEALTH "AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US  EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)1WORK GROUP.
                                                                                                                                                 R3-17

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                    May 1995




CROTONALDEHYDE                                             000123-73-9
        010190   CHUNG. FL. T TAMAKA. SS HECHT.  1986.  INDUCTION OF LIVER TUMORS IN F344 RATS BY CROTONALDEHYOE   CANCER RES. 46: 1285-1289.

                 US  EPA   1989  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CROTONALDEHYDE  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US  EPA   1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

CYANAZINE                                                   021725-46-2
        010944   BOGDANFFY MS. 1990. COMBINED CHRONIC TOXICITY/ONCOGENICITY STUDY WITH CYANAZINE (INR-1957) 2-YEAR FEEDING STUDY IN RATS  PREPARED BY E.I.
                 DU  PONT  DE NEMOURS AND CO.

                 US  EPA.  1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

ODD                                                          000072-54-8
        010291   TOMATIS. L. V TURUSOV. RT CHARLES AND M BOICCHI.  1974. EFFECT OF LONG-TERM EXPOSURE TO l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHYLENE. TO
                 l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHANE.  AND  TO THE TWO CHEMICALS COMBINED ON CF-1 MICE.  J  NATL CANCER INST. 52(3)- 883-891

                 US  EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DOE                                                          000072-55-9
        010292   TOMATIS  L  V TURUSOV. RT CHARLES AND M BOICCHI.  1974. EFFECT OF LONG-TERM EXPOSURE TO l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHYLENE. TO
                 l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHANE.  AND  TO THE TWO CHEMICALS COMBINED ON CF-1 MICE.  J  NATL CANCER INST. 52(3): 883-891

                 NCI (NATIONAL CANCER  INSTITUTE). 1978. BIOASSAY  OF DDT. TOE AND P.P'-DDE FOR POSSIBLE CARCINOGENICITY. NCI REPORT NO 131. DHEW PUBL NO
                 (NIH) 78-1386

                 ROSSI L. 0 BARBIERI. M SANGUINETI. JRP CABRAL. P BRUZZI AND L SANTI. 1983  CARCINOGENICITY  STUDY WITH TECHNICAL-GRADE DDT AND DDE IN
                 HAMSTERS. CANCER  RES. 43: 776-781.

                 US  EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                   R3-18

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                                                     REFERENCES FOR HEAST TABLE 3:   CARCINOGEN 1C ITY                                    May 1995



 DDT                                                           000050-29-3
         005044  US EPA. 1986. THE CARCINOGEN  ASSESSMENT GROUP'S EVALUATION OF THE CARCINOGEN 1C ITY OF  DICOFOL (KELTHANE)  DDT  DDE  AND ODD (TDE)
                 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT  GROUP. WASHINGTON. DC  FOR THE HAZARD EVALUATION
                 DIVISION.  OFFICE OF PESTICIDE PROGRAMS. OFFICE OF PESTICIDES AND TOXIC  SUBSTANCES. WASHINGTON. DC

                 US EPA. 1988. UPDATED HEALTH  EFFECTS ASSESSMENT FOR DDT.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC. EPA 540/1-86-026.

                 US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP.

 DECABROMODIPHENYL ETHER                                   001163-19-5
         010102  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DECABROMODIPHENYL OXIDE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.

                 US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP.

DIALLATE                                                     002303-16-4
         010103  BRL (BIONETICS RESEARCH  LABS.  INC.). 1968.  EVALUATION OF CARCINOGENIC.  TERATOGENIC.  AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES AND
                 INDUSTRIAL CHEMICALS.  VOL  1. CARCINOGENIC STUDY.  PREPARED  FOR  NATIONAL  CANCER INSTITUTE.  US DEPARTMENT OF COMMERCE.  WASHINGTON. DC. NTIS
                 r D- ttviiby .
                 INNES.  JRM.  BM ULLAND, MG VALERIO.  ET AL.  1969.  BIOASSAY  OF  PESTICIDES AND INDUSTRIAL CHEMICALS FOR TUMORIGENICITY IN MICE  A  PRELIMINARY
                 NOTE. J NATL CANCER INST. 42: 1101-1114.

                 US EPA.  1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR DIALLATE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON.  DC.

DIBENZO[A.H]ANTHRACENE                                    000053-70-3
        010191   REFER TO IRIS.

                 US EPA.  1990. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP
                                                                                                                                                   R3-19

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCINOGEN1CITY                                     May 1995
DIBROMO-3-CHLOROPROPANE. 1.2                             000096-12-8
        010519  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1982.  CARCINOGENESIS BIOASSAY OF 1.2-DIBROMO-3-CHLOROPROPANE (CAS NO 96-12-8)  IN F344 RATS AND B6C3F1
                MICE  (INHALATION STUDY). NTP-TR-NO 81-21.

                US EPA. 1989. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

        010484  HAZELTON LABORATORIES.  INC. 1977.  104 WEEK  DIETARY STUDY  IN RATS. 1.2-DIBROMO-3-CHLOROPROPANE (DBCP).  FINAL  REPORT. UNPUBLISHED REPORT
                SUBMITTED TO DOW CHEMICAL CO.. MIDLAND. MI.  OCTOBER 29. 1977.

                US EPA. 1988. DRINKING WATER CRITERIA DOCUMENT  FOR DIBROMOCHLOROPROPANE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER.  WASHINGTON DC.  ECAO-CIN-410.

                US EPA. 1988. ASSESSMENT OF THE CARCINOGENIC POTENTIAL OF 1.2-DIBROMO-3-CHLOROPROPANE (DBCP). PREPARED BY THE CARCINOGEN ASSESSMENT
                GROUP. AVAILABLE THROUGH RCRA/SUPERFUND DOCKET

DIBROMOCHLOROMETHANE                                       000124-48-1
        010891  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1985  TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORODIBROMOMETHANE (CAS  NO 124-48-1) IN F/344/N RATS
                AND  B6C3F1 MICE. NTP TECH REP SER NO 282. DHHS  NO NIH 85-2538.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA. 1989. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

DIBROMOETHANE.  1.2-                                        000106-93-4
        005071  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1982.  CARCINOGENESIS BIOASSAY OF 1.2-DIBROMOETHANE (ETHYLENE DIBROMIDE) (CAS NO 106-93-4)  IN F344 RATS
                AND  B6C3F1 MICE (INHALATION STUDY). NTP TECH REP SER NO 210. NIH PUBL NO 82-1766

                US EPA. 1987. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

        005818  NCI  (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1.2-DIBROMOETHANE FOR POSSIBLE CARCINOGENICITY  NCI CARCINOGENESIS  REPORT  SERIES NO
                86.  PB-288-428.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE DIBROMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR 1.2-DIBROMOETHANE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE.  WASHINGTON. DC

                US EPA. 1987. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

                                                                                                                                                   R3-20

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                                                    REFERENCES  FOR  HEAST  TABLE  3:   CARCINOGENICITY                                    Nay 1995



DICHLORO-2-BUTENE. 1.4-                                   000764-41-0
         005053  El  DUPONT DE NEMOURS AND CO.  1986. LONG-TERM INHALATION STUDY  WITH 1.4-DICHLOROBUTENE-2 (DCB)  IN RATS  FINAL REPORT OTS 8(E) FICHE
                 0509754.

                 US  EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DICHLOROBUTENES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON, DC.

DICHLOROBENZENE.  1.4-                                     000106-46-7
         005050  NTP (NATIONAL TOXICOLOGY PROGRAM). 1986.  TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.4-DICHLOROBENZENE IN F344/N RATS AND B6C3F1 MICE  --
                 GALLEY DRAFT. US DHHS.  PHS. NIH TECH REP SER NO 319.

                 CONTAMINANTS. 1987.  FR  (JULY  8).  52: 25690-25717.

DICHLOROBENZIDINE.  3.31-                                  000091-94-1
         005815  STULA. EF. H SHERMAN. JA ZAPP. ET AL. 1975.  EXPERIMENTAL NEOPLASIA IN RATS FROM ORAL ADMINISTRATION OF 3 3'-DICHLOROBENZIDINE
                 4.4'-METHYLENE-BIS(2-CHLOROANILINE) AND 4.4'-METHYLENE-BIS (2-METHYLANILINE)  TOXICOL APPL PHARMACOL. 31: 159-175.

                 US  EPA. 1988.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

DICHLOROETHANE.  1.1-                                       000075-34-3
         005055  US  EPA. 1984.  HEALTH EFFECTS  ASSESSMENT FOR 1.1-DICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON.  DC.

                 US  EPA. 1989.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DICHLOROETHANE.  1.2-                                       000107-06-2
         005058   NCI (NATIONAL CANCER INSTITUTE). 1978.  BIOASSAY OF  1.2-DICHLOROETHANE FOR POSSIBLE  CARCINOGENICITY. NCI CARCINOGENESIS TECH  REP SER NO
                 55.  DHEW PUBL NO (NIH)  78-1361.

                 US  EPA. 1985.  HEALTH ASSESSMENT DOCUMENT  FOR 1.2-DICHLOROETHANE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 WASHINGTON.  DC.  EPA  600/8-84-006F.

                 US EPA. 1986.  CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                 R3-21

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                    May 1995



ntrm OROFTHYI FNF   1 1-                                    000075-35-4
        005060  NTP' (NATIONAL TOXICOLOGY PROGRAM).  1982.  CARCINOGENESIS BIOASSAY OF VINYLIDENE CHLORIDE (CAS NO 75-35-4)  IN  F344 RATS AND B6C3F1 MICE
                (GAVAGE STUDY). NTP TECH REP SER NO 228.  DHHS NO NIH  82-1784.

                US  EPA 1985  HEALTH ASSESSMENT DOCUMENT FOR VINYLIDENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC

                US  EPA 1988  UPDATED HEALTH EFFECTS ASSESSMENT  FOR  1.1-DICHLOROETHYLENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US  EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.

         005059  MALTONI   C  G LEFEMINE  P CHIECO ET AL. 1985. EXPERIMENTAL  RESEARCH ON VINYLIDENE CHLORIDE CARCINOGENESIS. IN: ARCHIVES OF  RESEARCH ON
                 INDUSTRIAL'CARCINOGENESIS. VOL 3. c. MALTONI AND M  MEHLMAN.  ED. PRINCETON SCIENTIFIC PUBLISHERS. PRINCETON. NJ.

                US  EPA 1985  HEALTH ASSESSMENT DOCUMENT FOR VINYLIDENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC

                US  EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP

 nrrm OROPRDPANF   1 2-                                     000078-87-5
         005062  NTP (NATIONAL  TOXICOLOGY PROGRAM).  1986. NTP TECHNICAL REPORT ON THE CARCINOGENESIS  STUDIES OF  l^^ICHLOROPROPANE WOPYLENE
                 DICHLORIDE).  (CAS NO. 78-87-5)  IN  F344/N RATS  AND B6C3F1  MICE (GAVAGE STUDIES).  NTP-82-092. NIH PUBL  NO 84-2519.  NTP TR 263  US DHHS.
                 PHS. NIH. AUGUST. 1986  DRAFT.

                 US EPA  1987   HEALTH EFFECTS ASSESSMENT FOR 1.2-DICHLOROPROPANE.  PREPARED BY  THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA  AND  ASSESSMENT  OFFICE.  CINCINNATI. OH. FOR THE OFFICE  OF  SOLID  WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
                                                                                                                                                    R3-22

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                    Hay 1995



DICHLOROPROPENE.  1.3-  / (TELONE  II)                    000542-75-6
        010946   NTP  (NATIONAL TOXICOLOGY PROGRAM).  1985. TOXICOLOGY AND CARCINOGENESIS  STUDIES OF TELONE  II  IN F344/N RATS AND B6C3F1 MICE  US DEPT
                 HEALTH AND  HUMAN SERVICES. TECH REPORT  SER NO 269.

                 US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP

                 US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS  FOR  1.3-DICHLOROPROPENE  PREPARED BY THE OFFICE OF
                 HEALTH AND  ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI  OH FOR THE OFFICE OF WATER  WASHINGTON
                 DC.

        010104   LOMAX LG. WT STOTT. KA JOHNSON.  LL  CALHOUN. BL YANO AND JF QUAST  1989   THE CHRONIC TOXICITY AND ONCOGENICITY OF INHALED TECHNICAL GRADE
                 1.3-DICHLOROPROPENE IN RATS AND MICE  FUND APPL TOXICOL. 12: 418-431

                 US EPA. 1989. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR 1.3-DICHLOROPROPENE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA  AND  ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE  OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP
                                                                                                                                                  R3-23

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCINOGENICITY                                    Hay 1995




nmnoTM                                                     000060-57-1
         005816   NCI  (NATIONAL CANCER  INSTITUTE). 1978.  BIOASSAYS OF ALDRIN AND DIELDRIN FOR POSSIBLE CARCINOGENICITY.  NATIONAL  CANCER  INSTITUTE
                 CARCINOGEN TECH REP SER NO 22 NCI-CG-TR-22.  ALSO PUBL  AS DHEW PUBL NO (NIH) 78-882.

                 WALKER. AIT. E THORPE AND DE STEVENSON. 1972.  THE TOXICOLOGY OF  DIELDRIN (HEOD): I  LONG-TERM ORAL TOXICITY STUDIES IN MICE  FOOD COSMET
                 TOXICOL.  11: 415-432.

                 MEIERHENREY. EF.  BH REUBER. ME GERSHWIN ET AL. 1983. DIELDRIN  INDUCED MALLORY BODIES IN HEPATIC TUMORS OF MICE  OF DIFFERENT  STRAINS.
                 HEPATOLOGY.  3: 90-95.

                 TENNEKES,  HA. AS  WRIGHT. KM DIX AND JH KOEMAN. 1981. EFFECTS OF  DIELDRIN. DIET AND BEDDING ON ENZYME FUNCTION AND TUMOR INCIDENCE IN
                 LIVERS OF MALE CF-1 MICE. CANCER RES. 41: 3615-3620

                 THORPE  E AND AIT WALKER. 1973. THE TOXICOLOGY OF DIELDRIN (HEOD).  II.  COMPARATIVE LONG-TERM ORAL TOXICITY STUDIES IN MICE WITH DIELDRIN.
                 DDT. PHENOBARBITONE.  BETA-BHC AND GAMMA-BHC  FOOD COSMET TOXICOL.  11' 433-442

                 DAVIS. KJ.  1965.  PATHOLOGY REPORT ON MICE FED ALDRIN. DIELDRIN.  HEPTACHLOR  OR HEPATOCHLOR EPOXIDE FOR TWO YEARS. INTERNAL FDA MEMORANDUM
                 TO OR! AJ LEHMAN. JULY 19.

                 US EPA  1987  HEALTH EFFECTS ASSESSMENT  FOR DIELDRIN. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND 'ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF EMERGENCY  AND  REMEDIAL  RESPONSE. WASHINGTON. DC.

                 US EPA. 1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP


 DTETHYLSTILBESTROL                                         000056-53-1
         010485  GASS. ET AL. 1964. CARCINOGENIC DOSE-RESPONSE  CURVE TO ORAL DIETHYLSTILBESTEROL  J NATL  CANCER  INST.  33: 971-977.

                    FPA  1988  EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIETHYLSTILBESTEROL  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                       ^mim^oS^s^m  OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE  AND EMERGENCY  RESPONSE. WASHINGTON
                 DC.
 niMFTHnXYRFN7TniNE  33'-                                 000119-90-4
         010106  SELLAK'UMAR AR. R MONTESANO AND A SAFFIOTI.  1969.  AROMATIC AMINES CARCINOGENICITY IN HAMSTERS.  PROC AM ASSOC CANCER  RES.  10: 78.
                                 *
                 OSHA/NIOSH (OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION/NATIONAL  INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH). 1980.  HEALTH HAZARD.
                 ALERT BENZIDINE. 0-TOLIDINE AND 0-DIANISIDINE BASED DYES. DHHS  (NIOSH) PUBL NO. 81-106

                 US  EPA   1987   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  3.3'-DIMETHOXYBENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.

                 WASHINGTON. DC.

                                                                                                                                                    R3-24

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                                                    REFERENCES FOR  HEAST TABLE 3:   CARCINOGEN1CITY                                   May 1995



DIHETHYLANILINE HYDROCHLORIDE. 2.4-                    021436-96-4
        010108  WEISBURGER EK. AB RUSSFIELD.  F HOM8URGER. ET AL. 1978.  TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR  DERIVATIVES FOR LONG-TERM
                TOXICITY OR CARCINOGENICITY.  J ENVIRON PATHOL TOXICOL.  2:  325-356.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-DIMETHYLANILINE AND 2.4-DIMETHYLANILINE HYDROCHLORIDE. PREPARED BY THE
                OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE
                AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

DIMETHYLANILINE. 2.4-                                     000095-68-1
        010107  WEISBURGER EK. AB RUSSFIELD.  F HOMBURGER. ET AL. 1978.  TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR  DERIVATIVES FOR LONG-TERM
                TOXICITY OR CARCINOGENICITY.  J ENVIRON PATHOL TOXICOL.  2:  325-356.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-DIMETHYLANILINE AND 2.4-DIMETHYLANILINE HYDROCHLORIDE. PREPARED BY THE
                OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE
                AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

DIMETHYLBENZIDINE.  3.3'-                                  000119-93-7
        010109  GRISWOLD DP JR. AE CASEY. EK WEISBURGER AND JH WEISBURGER. 1968.  THE CARCINOGENICITY OF MULTIPLE INTRA-GASTRIC DOSES  OF AROMATIC AND
                HETEROCYCLIC NITRO OR AMINO DERIVATIVES IN YOUNG FEMALE SPRAGUE-DAWLEY  RATS  CANCER RES. 28(5): 924-933.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 3.3'-DIMETHYLBENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

DIMETHYLBENZ[A]ANTHRACENE.  7.12-                        000057-97-6
        010297  FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC ASSESSMENT OF THIS COMPOUND.

DIMETHYLHYDRAZINE.  1.2-                                   000540-73-8
        010962  TOTH B AND K PATEL. 1982. CARCINOGENICITY DOSE RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF 1.2-DIMETHYL HYDRAZINE  DIHYDROCHLORIDE IN
                MICE. I. LIGHT AND TRANSMISSION ELECTRON MICROSCOPE STUDY OF COLONIC NEOPLASMS  AM J PATH  84: 69-86

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2-DIMETHYLHYDRAZINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

                US EPA. 1989. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1.2-DIMETHYLHYDRAZINE  PREPARED BY THE CARCINOGEN ASSESSMENT GROUP. OFFICE
                OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND
                REMEDIAL RESPONSE AND  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.



                                                                                                                                                  R3-25

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                                                    REFERENCES  FOR HEAST  TABLE 3:   CARCINOGENICITY                                    Hay 1995
DIMETHYLSULFATE                                            000077-78-1
        010112  US EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYL SULFATE  PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND  EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DINITROTOLUENE. 2.4-                                      000121-14-2
        005066  ELLIS.  HV. SH HAGEUSEN. JR JODGSON ET AL. 1979. MAMMALIAN TOXICITY OF MUNITIONS COMPOUNDS. PHASE III  EFFECTS OF LIFETIME EXPOSURE. PART
                I. 2.4-DINITROTOLUENE. NTIS AD-A077692. 281 P.

                US EPA  1987  HEALTH EFFECTS ASSESSMENT FOR 2.4- AND 2.6-DINITROTOLUENES.  PREPARED BY THE OFFICE OF  HEALTH  AND  ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DINITROTOLUENE, 2.6-                                      000606-20-2
        005068  ELLIS HV.  SH HAGUESEN. JR JODGSON. ET AL. 1979. MAMMALIAN TOXICITY OF MUNITION COMPOUNDS. PHASE III. EFFECTS OF LIFETIME EXPOSURE. PART
                I. 2.4-DiNITROTOLUENE. NTIS AD-A077692. 281 P.

                US EPA  1987  HEALTH EFFECTS ASSESSMENT FOR 2.4- AND 2.6-DINITROTOLUENES.  PREPARED BY THE OFFICE OF  HEALTH  AND  ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

DIOXANE.  1.4-                                               000123-91-1
        010298  NCI  (NATIONAL CANCER INSTITUTE).  1978. BIOASSAY OF 1.4-DIOXANE FOR  POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 80. DHEW
                PUBLICATION NO  (NIH) PB-285-711.

                US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
                                                                                                                                                  R3-26

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                                                     REFERENCES FOR  HEAST TABLE 3:   CARCINOGEN1CITY                                    May 1995



DIPHENYLHYDRAZINE.  1.2-                                   000122-66-7
         005070  NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF HYDRAZOBENZENE FOR POSSIBLE  CARCINOGENICITY  NCI CARCINOGENESIS TECH REP SER NO 92
                 DHEW PUBL NO (NIH)  78-1342.

                 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 1.2-DIPHENYLHYDRAZINE.  PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE  OF  EMERGENCY  AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                 US EPA. 1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.2-DIPHENYLHYDRAZINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.

                 US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR  1.2-DIPHENYLHYDRAZINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS  WASHINGTON
                 DC.

                 US EPA. 1986. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP

DIRECT  BLACK 38                                             001937-37-7
         010113  NCI (NATIONAL CANCER INSTITUTE). 1978  13-WEEK SUBCHRONIC  TOXICITY  STUDIES ON DIRECT BLUE 6. DIRECT BLACK 38 AND DIRECT BROWN 95 DYES
                 NCI CARCINOGENESIS  TECH REP SER NO. 108.  P 127.

                 US EPA. 1987. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE  FOR DIRECT BLACK 38   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.

DIRECT  BLUE  6                                               002602-46-2
         010114  NCI (NATIONAL CANCER INSTITUTE). 1978. 13-WEEK SUBCHRONIC  TOXICITY  STUDIES OF DIRECT BLUE 6. DIRECT BLACK 38  AND DIRECT BROWN 95 DYES
                 NCI CARCINOGENESIS.  TECH  REP SER NO.  108.  P 127.

                 US EPA.  1987. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE  FOR DIRECT BLUE  6  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE  OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

DIRECT  BROWN 95                                             016071-86-6
         010115  NCI (NATIONAL CANCER INSTITUTE). 1978. 13-WEEK SUBCHRONIC  TOXICITY  STUDIES OF DIRECT BLUE 6. DIRECT BLACK 38  AND DIRECT BROWN 95 DYES
                 NCI CARCINOGENESIS.  TECH  REP SER NO.  108.  P 127                                                             '

                 US  EPA.  1987.  HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE  FOR DIRECT BROWN 95   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH  FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.



                                                                                                                                                   R3-27

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCINOGENICITY                                    May 1995
DIRECT  SKY BLUE 6B                                         002610-05-1
         010116   US EPA   1987  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE  FOR DIRECT SKY BLUE 6B. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

EPICHLOROHYDRIN                                             000106-89-8
         010117   LASKIN  S. AR  SELLAKUMAR. M KUSCHNER.  ET AL.  1980.  INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN NON-INBRED SPRAGUE-DAWLEY  RATS. J NATL
                 CANCER  INST.  65(4): 751-757.

                 US EPA   1984  HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYORIN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  RESEARCH  TRIANGLE PARK. NC  EPA 600/8-83-032F. NTIS PB85-132363.

                 US EPA   1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR EPICHLOROHYDRIN  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA.  1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

         010198   KONISHI.  T. A KAWABATA. A DENDA. ET AL. 1980.  FORESTOMACH TUMORS  INDUCED BY ORALLY ADMINISTERED EPICHLOROHYDRIN IN MALE WISTAR  RATS.
                 GANN. 71: 922-923.

                 US EPA   1984  HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  RESEARCH TRIANGLE PARK. NC. EPA 600/8-83-032F. NTIS PB85-132363.

                 US EPA   1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  EPICHLOROHYDRIN  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA.  1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

ETHYL ACRYLATE                                              000140-88-5
         010118   NTP  (NATIONAL TOXICOLOGY PROGRAM). 1986  CARCINOGENESIS STUDIES OF  ETHYL ACRYLATE  IN F344/N RATS AND B6C3F1 MICE  (GAVAGE STUDIES).

                 US EPA   1987  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  ETHYL  ACRYLATE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR  THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.
                                                                                                                                                   R3-28

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                                                    REFERENCES  FOR  HEAST TABLE 3:   CARCINOGENICITY                                    May 1995



ETHYLENE OXIDE                                              000075-21-8
         010421  DUNKELBERG H.  1982.  CARCINOGENICITY OF ETHYLENE OXIDE AND 1.2-PROPYLENE OXIDE UPON  INTRA-GASTRIC ADMINISTRATION TO RATS.  BR J CANCER. 46:
                 924-933.

                 US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR OXIRANE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

         010422  SNELLINGS WM.  CS WEIL AND RR MORONPOT. 1981.  FINAL REPORT.  ETHYLENE  OXIDE. TWO YEAR INHALATION STUDY. SUBMITTED TO THE US ENVIRONMENTAL
                 PROTECTION AGENCY  BY BUSHEY RUN RESEARCH CENTER.  PITTSBURGH PA.

                 US EPA.  1985.  HEALTH ASSESSMENT DOCUMENT FOR ETHYLENE OXIDE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE  PARK.  NC.  EPA  600/8-84-009F  NTIS PB86-102597.

ETHYLENE THIOUREA                                          000096-45-7
         010947  NTP (NATIONAL  TOXICOLOGY PROGRAM). 1992. NTP TECHNICAL REPORT ON THE PERINATAL TOXICOLOGY AND CARCINOGENESIS STUDIES OF ETHYLENE  THIOUREA
                 (CAS NO  96-45-7) IN  F344/N RATS AND B6C3F1 MICE.  (FEED STUDIES).  NTP TR 388  US DEPT OF HEALTH AND HUMAN SERVICES. PUBLIC HEALTH  SERVICE.
                 NATIONAL  INSTITUTES  OF HEALTH.

                 US EPA.  1993.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

FOLPET                                                        000133-07-3
         010120  CHEVRON CHEMICAL COMPANY. 1982. CHEVRON STUDY:  LIFETIME ONCOGENICITY FEEDING STUDY OF PHOLTON TECHNICAL (SX-946  FOLPET)  IN CD-I  (ICR
                 DERIVED)  MICE. AUGUST 24. SOCIAL STUDY NO. 1331.

                 US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FOLPET. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA. 1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

FORMALDEHYDE                                                000050-00-0
         010121   KERNS ET  AL..  1983.  CARCINOGENICITY OF FORMALDEHYDE IN RATS AND  MICE AFTER LONG-TERM INHALATION EXPOSURE.  CANCER RES.  43(9):  4382-4392.

                 US EPA. 1988.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

                 US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FORMALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI.  OH.  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.
                                                                                                                                                   R3-29

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                                                    REFERENCES FOR HEAST TABLE  3:   CARCINOGENICITY                                    May 1995



FURAZOLIDONE                                                000067-45-8
        005106  US OHEW. 1976. FUROZOLIOONE (NF-180):  NOTICE OF OPPORTUNITY FOR HEARING ON PROPOSAL  TO WITHDRAW APPROVAL OF CERTAIN NEW ANIMAL DRUG
                APPLICATIONS. FEDERAL REGISTER.  41:  19907-19921.

                US DHEW. 1976. FUROZOLIDONE.  NIHYDRAZONE. FURALTADONE. NITROFURAZONE.  WITHDRAWAL OF  PROPOSALS AND NOTICE OF PROPOSED RULE MAKING.  FEDERAL
                REGISTER. 41: 34884-34921.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITROFURANS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

FURIUM                                                       000531-82-8
        005108  COHEN. SM. E ERTURK AND GT BRYAN.  1970.  PRODUCTION OF LEUKEMIA AND STOMACH NEOPLASMS IN SWISS. RF. BALB/C AND C3H FEMALE MICE BY FEEDING
                N-(4.5-NITRO-2-FURYL-2-THIAZOLYL)ACETAMIDE  CANCER RES. 30(9): 2320-2325

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITROFURANS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

GLYCIDALDEHYDE                                              000765-34-4
        010122  US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR GLYCIDALDEHYDE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                  R3-30

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                                                     REFERENCES  FOR  HEAST TABLE 3:   CARCINOGENICITY                                    May 1995



HEPTACHLOR                                                   000076-44-8
         005820  DAVIS K.  1965.  PATHOLOGY  REPORT ON MICE FED ALDRIN.  DIELDRIN,  HEPTACHLOR. AND  HEPTACHLOR EPOXIDE FOR TWO YEARS. INTERNAL FDA MEMORANDUM
                 TO DR.  AJ LEHMAN.  JULY  19.

                 NCI (NATIONAL CANCER  INSTITUTE). 1977. BIOASSAY OF HEPTACHLOR FOR POSSIBLE  CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 9.  DHEW NO
                 (NIH) 77-809.

                 EPSTEIN.  SS.  1976.  CARCINOGENICITY OF HEPTACHLOR AND CHLORDANE.  SCI  TOTAL ENVIRON  6.  103-154.

                 REUBER. MD.  1977.  HISTOPATHOLOGY OF CARCINOMAS OF THE LIVER IN MICE  INGESTING  HEPTACHLOR OR HEPTACHLOR EPOXIDE. EXP CELL BIOL.  45:
                 147-157.

                 US EPA.  1986. CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE  PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP.  WASHINGTON. DC.

                 US EPA.  1987. HEALTH  EFFECTS ASSESSMENT FOR HEPTACHLOR.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                 CRITERIA  AND  ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY  AND REMEDIAL RESPONSE, WASHINGTON.  DC.

                 US EPA. 1987. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

HEPTACHLOR EPOXIDE                                         001024-57-3
         010424  DAVIS KJ.  1965.  PATHOLOGY REPORT ON MICE FED ALDRIN.  DIELDRIN. HEPTACHLOR AND  HEPTACHLOR EPOXIDE FOR TWO YEARS  INTERNAL FDA MEMORANDUM
                 TO DR. A.J. LEHMAN. JULY  19.

                 VELSICOL  CHEMICAL  CORPORATION. 1973.  MRID NO.  00062678.  AVAILABLE FROM EPA  WRITE TO FOI. EPA. WASHINGTON. DC 20460.

                 US EPA. 1987. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

HEXACHLOROBENZENE                                          000118-74-1
         010365  ERTURK £.  RW  LAMBRECHT. HA PETERS.  DJ CRIPPS £T AL.  1986.  ONCOGENICITY OF HEXACHLROBENZENE. IN: HEXACHLROBENZENE:  PROC  INT SYMP.  CR
                 MORRIS AND JRP CABRAL.  ED. IARC SCIENTIFIC PUBL NO.  77.  OXFORD UNIVERSITY PRESS. OXFORD  P 417-423.

                 US EPA. 1991. DRINKING  WATER CRITERIA DOCUMENT FOR HEXACHLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF DRINKING WATER1. WASHINGTON. DC.

                 US EPA. 1984. HEALTH  EFFECTS ASSESSMENT FOR HEXACHLOROBENZENE. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI.  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                 US EPA. 1989. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP



                                                                                                                                                   R3-31

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                    May 1995




HEXACHLOROBUTADIENE                                        000087-68-3
         005088   KOCIBA. RJ. DG KEYS. GC JERSEY.  ET AL.  1977.  RESULTS OF A2-YEAR CHRONIC TOXICITY STUDY  WITH HEXACHLOROBUTADIENE IN RATS.  AM IND  HYG ASSOC
                 J.  38: 589-602.

                 US  EPA. 1980. AMBIENT WATER QUALITY CRITERIA  DOCUMENT FOR HEXACHLOROBUTADIENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS  WASHINGTON
                 DC.

                 US  EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROBUTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF  EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.  DC.

                 US  EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP

HEXACHLOROCYCLOHEXANE.  ALPHA-                            000319-84-6
         010123   ITO N. H NAGASAKI. M ARIA. ET AL.  1973.  HISTOLOGICAL AND ULTRASTRUCTURAL  STUDIES ON  THE HEPATOCARCINOGENICITY OF BENZENE  HEXACHLORIDE IN
                 MICE. J NATL CANCER INST. 51: 817-826.

                 US  EPA. 1987. HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON, DC.

                 US  EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP.

HEXACHLOROCYCLOHEXANE.  BETA                              000319-85-7
         010124   THORPE E AND AIT WALKER. 1973. TOXICOLOGY OF  DIELDRIN (HEOD) II. COMPARATIVE LONG-TERM  ORAL TOXICITY STUDIES IN MICE WITH DIELDRIN  DDT
                 PHENOBARBITONE. BETA-HCH AND GAMMA-HCH.  FOOD  COSMET TOXICOL. 11: 433-442

                 US  EPA. 1987. HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH'AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON. DC.

                 US  EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP
                                                                                                                                                  R3-32

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                                                   REFERENCES  FOR HEAST  TABLE 3:   CARCINOGENICITY                                   May 1995
HEXACHLOROCYCLOHEXANE.  DELTA-                            000319-86-8
        010125   ITO N. H NAGASAKI.  H AOE.  ET AL. 1975. BRIEF COMMUNICATION:  DEVELOPMENT OF HEPATOCELLULAR CARCINOMAS IN RATS TREATED WITH
                 BENZENEHEXACHLORIDE.  J NATL  CANCER INST. 54: 801-805.

                 ITO N. H NAGASAKI.  M ARIA. ET AL. 1973. HISTOLOGICAL AND ULTRASTRUCTURAL  STUDIES ON THE HEPATOCARCINOGENICITY OF BENZENE HEXACHLORIDE IN
                 MICE. J NATL CANCER INST.  51: 817-826.

                 US EPA  1987  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR  THE OFFICE-OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

HEXACHLOROCYCLOHEXANE.  EPSILON-                         006108-10-7
        010126   GOTO  M. M HATTORI.  T MIYAGAWA AND M  ENOMOTO. 1972. ECOLOGICAL CHEMISTRY   II   HEPATOHA  FORMATION IN MICE AFTER ADMINISTRATION OF  HIGH
                 DOSES OF HEXACHLOROCYCLOHEXANE  ISOMERS. CHEMOSPHERE. 1: 279-282.

                 US EPA  1987  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

HEXACHLOROCYCLOHEXANE.  GAMMA-                           000058-89-9
        005098   THORPE. E AND AIT WALKER. 1973. THE  TOXICOLOGY OF DIELDRIN (HEOD). II. COMPARATIVE LONG-TERM ORAL TOXICITY STUDIES IN MICE WITH DIELDRIN.
                 DDT.  PHENOBARBITONE. BETA-BHC AND GAMMA-BHC. FOOD COSMET TOXICOL. 11:  433-442

                 US EPA  1987  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON
                 DC.

                 US EPA  1984  HEALTH EFFECTS ASSESSMENT FOR LINDANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH.  FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON.  DC.
                                                                                                                                                   R3-33

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCINOGENICITY                                    May 1995




HEXACHLOROCYCLOHEXANE-TECHNICAL                          000608-73-1
         010127  MUNIR KM. CS SOMAN AND V SUMATI.  1983.  HEXACHLOROCYCLOHEXANE-INDUCED TUMORIGENICITY IN MICE  UNDER DIFFERENT EXPERIMENTAL CONDITIONS
                TUMORIGENICITY. 69: 383-386.

                US EPA.  1987. HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR HEXACHLOROCYCLOHEXANES  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

                US EPA.  1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

HEXACHLOROETHANE                                            000067-72-1
         005090  NCI (NATIONAL CANCER INSTITUTE).  1978.  BIOASSAY OF HEXACHLOROETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 68
                DHEW NO  (NIH) 78-1318.

                US EPA.  1989. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR HEXACHLOROETHANE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                WASHINGTON. DC.

                US EPA.  1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED  ETHANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS  WASHINGTON
                DC.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON.  DC.

                US EPA.   1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP.
                                                                                                                                                  R3-34

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                                                    REFERENCES FOR HEAST TABLE  3:   CARCINOGENICITY                                    Hay 1995




HYDRAZINE                                                    000302-01-2
        010129   BIANCIFIORI C.  1970. HEPATOMAS IN CBA/CB/SE MICE  AND LIVER  LESIONS  IN GOLDEN HAMSTERS INDUCED BY HYDRAZINE SULFATE  J NATL CANCER INST.
                 44:  943.

                 US EPA  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  HYDRAZINE AND  HYDRAZINE SULFATE.  PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE.  WASHINGTON. DC.

                 US EPA.  1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE)  WORK GROUP.

         010128   MACEWEN JD.  EH VERNOT. CC HAUN. ER KINKEAD AND A HALL. III. 1981.  CHRONIC INHALATION  TOXICITY OF HYDRAZINE: ONCOGENIC EFFECTS. AIR FORCE
                 AEROSPACE MEDICAL RESEARCH LABORATORY. WRIGHT-PATTERSON AIR FORCE BASE. OH.

                 US EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE  AND  HYDRAZINE  SULFATE   PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL  ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE.  WASHINGTON. DC.

                 US EPA. 1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK GROUP

HYDRAZINE  SULFATE                                          010034-93-2
         010131   BIANCIFIORI C. 1970.  HEPATOMAS  IN CBA/CB/SE MICE AND  LIVER LESIONS IN GOLDEN HAMSTERS INDUCED BY  HYDRAZINE SULFATE.  J NATL  CANCER  INST.
                 44: 943.

                 US EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE AND HYDRAZINE SULFATE  PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON.  DC.

                 US EPA. 1987.  CARCINOGEN RISK  ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP

         010130  MACEWEN JD. EH VERNOT.  CC HAUN.  ER  KINKEAD AND A HALL.  III. 1981.  CHRONIC  INHALATION TOXICITY OF HYDRAZINE: ONCOGENIC  EFFECTS  AIR FORCE
                 AEROSPACE MEDICAL RESEARCH LABORATORY. WRIGHT-PATTERSON AIR FORCE  BASE. OH

                 US  EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE  FOR HYDRAZINE AND  HYDRAZINE SULFATE. PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON. DC.

                 US  EPA.  1987. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                     R3-35

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                                                    REFERENCES FOR HEAST TABLE  3:   CARCINOGEN1CITY                                    Nay 1995



 INDENO[1.2.3-CD]PYRENE                                    000193-39-5
         010192   REFER TO IRIS.

                 US EPA.  1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

 ISOPHORONE                                                   000078-59-1
         005094   NTP (NATIONAL TOXICOLOGY PROGRAM).  1986.  TOXICOLOGY AND CARCINOGENESIS STUDIES OF ISOPHORONE (CAS NO 78-59-1) IN F344/N RATS AND B6C3F1
                 MICE (GAVAGE STUDIES). NTP TECH REP SER NO  291. DHHS (NIH)86-2547.

                 US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ISOPHORONE. PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.

                 US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR ISOPHORONE. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                 US EPA.  1992. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP

LEAD                                                          007439-92-1
         005096   US EPA.  1989. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF LEAD AND LEAD COMPOUNDS. PREPARED BY THE CARCINOGEN ASSESSMENT GROUP OFFICE
                 OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  WASHINGTON DC FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON DC

                 US EPA.  1984. HEALTH EFFECTS ASSESSMENT FOR LEAD. PREPARED BY THE OFFICE  OF  HEALTH  AND ENVIRONMENTAL ASSESSMENT  ENVIRONMENTAL  CRITERIA
                 AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.  WASHINGTON. DC.

                 US EPA.  1988. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP.

LINURON                                                       000330-55-2
        010383   REFER TO IRIS.

                 US EPA.  1989. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP
                                                                                                                                                 R3-36

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                                                    REFERENCES  FOR HEAST  TABLE  3:   CARCINOGENICITY                                    May 1995
MERCURIC  CHLORIDE                                          007487-94-7
        010971  NTP (NATIONAL TOXICOLOGY PROGRAM).  1993.  TOXICOLOGY AND CARCINOGENESIS STUDIES OF MERCURIC CHLORIDE  (CAS NO. 7487-94-7) IN F344 RATS
                AND B3C3F1 MICE (GAVAGE STUDIES).  NTP TECHNICAL REPORT SERIES NO 408.  NATIONAL TOXICOLOGY PROGRAM.  U.S. DEPARTMENT OF HEALTH AND HUMAN
                SERVICES. PUBLIC HEALTH SERVICE. NATIONAL INSTITUTES OF HEALTH.  RESEARCH TRIANGLE PARK,  NC.

                U.S. EPA.  1995.  MERCURY STUDY REPORT TO CONGRESS.   OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON. DC.  EXTERNAL REVIEW DRAFT.
                EPA/600/P-94/002Ab.

                U.S. EPA.  1994.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

MERCURY.  ELEMENTAL                                         007439-97-6
        010973  CRAGLE. D.L.. D.R. HOLLIS. J.R. QUALTERS. W G. TANKERSLEY AND S A.  FRY    1984   A MORTALITY STUDY OF MEN EXPOSED TO ELEMENTAL MERCURY.
                J. OCCUP. MED. 26(11): 817-821.

                U.S. EPA.  1995.  MERCURY STUDY REPORT TO CONGRESS.   OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON. DC.   EXTERNAL REVIEW DRAFT.
                EPA/600/P-94/OOAb.

                U.S. EPA.  1994.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

METHOXY-5-NITROANILINE.  2-                               000099-59-2
        010132  NCI  (NATIONAL CANCER  INSTITUTE).  1978. BIOASSAY OF 5-NITRO-O-ANISIDINE  FOR POSSIBLE CARCINOGENICITY.  NCI CARCINOGENESIS  TECH REP SER NO.
                127. 123  P.

                US EPA  1987  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXY-5-NITROANILINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

METHYL-5-NITROANILINE.  2-                                000099-55-8
        010140  NCI  (NATIONAL CANCER  INSTITUTE).  1978. BIOASSAY OF 5-NITRO-O-TOLUIDINE FOR POSSIBLE CARCINOGENICITY  NCI CARCINOGEN TECH REP SER NO. 107.
                 102  P.

                US EPA  1987  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYL-5-NITROANILINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR  THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.
                                                                                                                                                  R3-37

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGEN1CITY                                   May 1995




METHYLANILINE HYDROCHLORIDE.  2-                         000636-21-5
         010134   HECHT SS. A El-BOYOUMY. A RIVENSON AND E FIALA. 1982. COMPARATIVE CARCINOGENICITY OF 0-TOLUIDINE HYDROCHLORIDE AND 0-NITROSOTOLUENE IN
                 F-344 RATS. CANCER LETT. 16(1):  103-108.

                 US  EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYLANILINE AND 2-METHYLANILINE HYDROCHLORIDE  PREPARED BY THE OFFICE OF
                 HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND
                 EMERGENCY RESPONSE. WASHINGTON.  DC.

METHYLANILINE. 2-                                          000095-53-4
         010133   HECHT SS. A EL-BOYOUMY. A RIVENSON AND E FIALA. 1982. COMPARATIVE CARCINOGENICITY OF 0-TOLUIDINE HYDROCHLORIDE AND 0-NITROTOLUENE IN
                 F-344 RATS. CANCER LETT. 16(1):  103-108.

                 US  EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYLANILINE AND 2-METHYLANILINE HYDROCHLORIDE  PREPARED BY THE OFFICE OF
                 HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF SOLID WASTE AND
                 EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US  EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIDINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE. WASHINGTON.  DC.

METHYLCHOLANTHRACENE. 3-                                  000056-49-5
         010299   FOR RCRA ACTIVITIES ONLY.  CONTACT  THE HEALTH ASSESSMENT SECTION (202) 260-4761 FOR RCRA APPROVED NUMERIC ASSESSMENT OF THIS COMPOUND
                                                                                                                                                 R3-38

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGEN1CITY                                    May 1995
METHYLENE CHLORIDE /  (DICHLOROMETHANE)                 000075-09-2
        005100   NCA  (NATIONAL COFFEE ASSOCIATION).  1983. TWENTY-FOUR MONTH ONCOGENICITY STUDY OF  METHYLENE CHLORIDE IN MICE. PREPARED BY HAZELTON
                 LABORATORIES. AMERICA INC.  VIENNA.  VA.

                 NTP  (NATIONAL TOXICOLOGY PROGRAM).  1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF DICHLOROMETHANE (METHYLENE CHLORIDE) (CAS NO 75-09-2)
                 IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES). NTP TECH REP SER NO 306. DHHS (NIH)  86-2562.

                 US EPA  1985  ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR DICHLOROMETHANE (METHYLENE CHLORIDE). UPDATED CARCINOGENICITY ASSESSMENT  OF
                 DICHLOROMETHANE (METHYLENE CHLORIDE).  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  CARCINOGEN ASSESSMENT GROUP. WASHINGTON.  DC.

                 US EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

        005904   NTP  (NATIONAL TOXICOLOGY PROGRAM).  1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF DICHLOROMETHANE (METHYLENE CHLORIDE) (CAS NO 75-09-2)
                 IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES). NTP TECH REP SER NO 306. OHHS (NIH)  86-2562.

                 US EPA  1989  UPDATED HEALTH EFFECTS ASSESSMENT FOR METHYLENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY  AND REMEDIAL RESPONSE. WASHINGTON. DC

                 US EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

METHYLENE-BIS(2-CHLOROANILINE).  4.4'-                  000101-14-4
        010425   KOMMINENI C. DH GROTH. IJ FROCKT. RW VOELKER AND  RP STANOVICK. 1979. DETERMINATION OF THE TUMORIGENIC POTENTIAL OF
                 METHYLENE-BIS-ORTHO-CHLOROANILINE.  J ENVIRON PATH TOXICOL. 2(5): 149-171.

                 STULA EF H SHERMAN  JP ZAPP  JR AND JW CLAYTON.  1975. EXPERIMENTAL NEOPLASIA IN RAT FROM ORAL ADMINISTRATION  OF 3.3-DICHLOROBENZIDINE.
                 4.4-METHYLENE-BIS(2-CHLOROANiLINE)  AND 4.4-METHYLENE-BIS(2-METHYLANILINE)  TOXICOL APPL PHARMACOL   31(1).  159-176.

                 US EPA  1990  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR 4.4-METHYLENE-BIS(2-CHLOROANILINE).  PREPARED  BY THE OFFICE OF  HEALTH AND
                 ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE  AND EMERGENCY
                 RESPONSE. WASHINGTON. DC.

METHYLENE-BIS(N.N'-DIMETHYL)ANILINE.  4.41-            000101-61-1
        010137   NCI  (NATIONAL CANCER  INSTITUTE). 1979. BIOASSAY OF 4.41-METHYLENE-BIS(N.N'-DIMETHYL)BENZENAMINE  FOR POSSIBLE CARCINOGENICITY.  NCI
                 CARCINOGEN. TECH  REP SER NO. 186. CAS 101-61-1.

                 US EPA  1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4.4'-METHYLENE-BIS(N.N1-DIMETHYDANILINE.  PREPARED  BY THE  OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE  OF  SOLID WASTE  AND  EMERGENCY
                 RESPONSE. WASHINGTON. DC.

                 US EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION  ENDEAVOR  (CRAVE)  WORK  GROUP.

                                                                                                                                                   R3-39

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                   May 1995



METHYLMERCURY                                              022%7-92-6
         010972   TAMASHIRO. H.. M. ARAKAKI.  H.  AKAGI. M. FUTATSUKA AND L.H.  ROHT.   1984.  CAUSES OF DEATH IN MINAMATA DISEASE- ANALYSIS OF DEATH
                 CERTIFICATES.. INT. ARCH.  OCCUP.  ENVIRON. HEALTH.  54: 135-146.

                 U.S. EPA.  1995.  MERCURY STUDY REPORT TO CONGRESS.   OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON  DC   EXTERNAL REVIEW DRAFT
                 EPA/600/P-94/002Ab.

                 U.S. EPA.  1994 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP

METOLACHLOR                                                 051218-45-2
         010951   US EPA. 1993. REVISED AND UPDATED DRINKING MATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METOLACHLOR  PREPARED BY THE OFFICE OF HEALTH
                 AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE  OFFICE OF WATER. WASHINGTON.  DC.

HIREX                                                        002385-85-5
         010952   NTP (NATIONAL TOXICOLOGY PROGRAM). 1990. NTP TECHNICAL REPORT  ON THE TOXICOLOGY AND CARCINOGENESIS  STUDIES OF MIREX (CAS NO 2385-85-5)  IN
                 F344/N RATS.  (FEED STUDIES). NTP  TR 313. US DEPT OF  HEALTH  AND HUMAN SERVICES. PUBLIC HEALTH SERVICE  NATIONAL INSTITUTES OF HEALTH.

                 US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

NIAGARA BLUE 46                                            002429-74-5
         010141   US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  NIAGARA BLUE 4B  PREPARED BY  THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON.  DC.
                                                                                                                                                R3-40

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCINOGENICITY                                    May 1995
NICKEL REFINERY DUST
        005103   CHOVIL. A. RB SUTHERLAND AND M HALLIDAY.  1981.  RESPIRATORY CANCER IN A COHORT OF NICKEL SINTER PLANT WORKERS. BR J  IND MED. 38. 327-333.

                 PETO. J. H CUCKLE. R DOOL. ET AL.  1984.  RESPIRATORY CANCER MORTALITY OF WELSH NICKEL REFINERY WORKERS.  IN:  NICKEL  IN THE HUMAN
                 ENVIRONMENT: PROCEEDINGS OF A JOINT SYMPOSIUM.  MARCH.  1983.  IARC SCIENTIFIC PUBL NO 53. IARC. LYON.  FRANCE.  P.  36-46.


                 ENTERLINE. PE AND GM MARSH. 1982.  MORTALITY AMONG WORKERS IN A NICKEL REFINERY AND ALLOY MANUFACTURING  PLANT IN WEST VIRGINIA  J NAT
                 CANCER  INST. 68: 925-933.

                 MAGNUS. K. A ANDERSEN AND A HOGETVEIT.  1982.  CANCER OF RESPIRATORY ORGANS AMONG WORKERS AT A NICKEL REFINERY IN NORWAY   INT J CANCER. 30:
                 681-685.

                 US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR NICKEL.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

                 US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NICKEL SUBSULFIDE                                          012035-72-2
        005768   CHOVIL. A. RB SUTHERLAND AND M HALLIDAY.  1981.  RESPIRATORY CANCER IN A COHORT OF NICKEL SINTER PLANT WORKERS.  BR J IND MED. 38. 327-333

                 PETO. J. H CUCKLE. R DOOL. ET AL.  1984.  RESPIRATORY CANCER MORTALITY OF WELSH NICKEL REFINERY WORKERS.  IN:  NICKEL  IN THE HUMAN
                 ENVIRONMENT: PROCEEDINGS OF A JOINT SYMPOSIUM.  MARCH.  1983.  IARC SCIENTIFIC PUBL NO 53. IARC. LYON. FRANCE. P.  36-46.

                 ENTERLINE. PE AND GM MARSH. 1982.  MORTALITY AMONG WORKERS IN A NICKEL REFINERY AND ALLOY MANUFACTURING PLANT IN WEST VIRGINIA  J NAT
                 CANCER  INST. 68: 925-933.

                 MAGNUS. K. A ANDERSEN AND A HOGETVEIT.  1982.  CANCER OF RESPIRATORY ORGANS AMONG WORKERS AT A NICKEL REFINERY IN NORWAY   INT J  CANCER. 30:
                 681-685.

                 US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR NICKEL.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.

                 US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROBENZENE                                               000098-95-3
        010969   CUT.   1993.  CHRONIC INHALATION TOXICITY STUDY OF NITROBENZENE  IN B6C3F1 MICE. FISHER 344 RATS. AND SPRAGUE-DAWLEY CD RATS.  CUT.  PO BOX
                 12137.  RESEARCH TRIANGLE PARK. NC. 27709.

                 US EPA.  1994.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE)

                                                                                                                                                   R3-41

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                                                    REFERENCES  FOR HEAST TABLE  3:   CARCINOGEN1CITY                                   May 1995



NITROFURAZONE                                               000059-87-0
         005110   ERTURK.  E.  JE  MORRIS. SM COHEN. ET AL.  1970.  TRANSPLANTABLE RAT MAMMARY TUMORS INDUCED BY 5-NITRO-2-FURALOEHYDE SEMICARBAZONE AND BY
                 FORMIC ACID 2-[4-(5-NITRO-2-FURYL)-2-THIAZOLYL]HYDRAZIDE. CANCER RES. 30(5). 1409-1412

                 US EPA.  1987.  HEALTH AND ENVIRONMENTAL  EFFECTS  DOCUMENT FOR SELECTED NITROFURANS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND  ASSESSMENT  OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.

NITROPROPANE.  2-                                            000079-46-9
         010142   LEWIS  TR. CE ULRICH AND WM BUSEY.  1979.  SUBCHRONIC INHALATION TOXICITY OF NITROMETHANE AND 2-NITROPROPANE  J ENVIRON PATHOL TOXICOL
                 2(5):  233-249.

                 US EPA.  1985.  HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR 2-NITROPROPANE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA.  1988.  EVALUATION OF THE POTENTIAL  CARCINOGENICITY OF 2-NITROPROPANE  PREPARED BY THE CARCINOGEN ASSESSMENT GROUP  OFFICE OF
                 HEALTH AND  ENVIRONMENTAL ASSESSMENT.  WASHINGTON DC. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON DC

NITROSO-DI-N-BUTYLAMINE.  N-                               000924-16-3
         010143   BERTRAM  JS  AND AW CRAIG. 1970. INDUCTION OF BLADDER TUMORS IN MICE WITH DIBUTYLNITROSAMINES.  BR. J CANCER. 24: 352-359

                 US EPA.  1986.  HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR NITROSAMINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US EPA.  1986.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSO-DI-N-PROPYLAMINE.  N-                              000621-64-7
         010147   DRUCKREY H.  1967. QUANTITATIVE ASPECTS  IN  CHEMICAL CARCINOGENS.  IN. POTENTIAL CARCINOGENIC HAZARDS FROM DRUGS  UICC MONOGRAPH  SERIES 7
                 SPRINGER-VERLAG. BERLIN. P 60-78.

                 DRUCKREY H. R  PURESSMAN. S IVANKOVIC AND D SCHMAHL. 1967. ORGANOTROPIC CARCINOGENIC EFFECT  OF  65 DIFFERENT N-NITROSO COMPOUNDS ON BD
                 RATS.  Z  KREBSFORSCH.  69: 103-201.

                 US  EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR NITROSAMINES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US  EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                  R3-42

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                                                    REFERENCES FOR HEAST TABLE  3:   CARCINOGENICITY                                    May 1995



NITROSO-N-ETHYLUREA.  N-                                   000759-73-9
         010426  BULAY.  0.  SS MIRVISH. H GARCIA.  AF PELFRENE.  B  GOLD AND M EAGAN  1979  CARCINOGENICITY TESTS OF SIX NITROSAMIDES AND NITROSOCYANAMIDE
                 ADMINISTERED ORALLY TO RATS. J NATL CANCER  INST 62:  1523-1528.

                 US EPA.  1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSO-N-ETHYLUREA  IN SUPPORT OF  REPORTABLE QUANTITY ADJUSTMENTS
                 PURSUANT TO CERCLA SECTION 102.  PREPARED BY THE CARCINOGEN ASSESSMENT GROUP.  OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.  WASHINGTON.
                 DC FOR  THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

                 US EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSO-N-METHYLUREA.  N-                                   000684-93-5
         010427  REDDY.  JK AND MS RAO. 1975. PANCREATIC ADENOCARCINOMA IN INBRED GUINEA PIGS INDUCED BY N-METHYL-N-NITROSOUREA. CANCER RES.  35:  2269-2277.

                 US EPA.  1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSO-N-METHYLUREA  IN SUPPORT OF REPORTABLE QUANTITY ADJUSTMENTS
                 PURSUANT TO CERCLA SECTION 102.  PREPARED BY THE CARCINOGEN ASSESSMENT GROUP.  OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT.  WASHINGTON.
                 DC FOR  THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC

                 US EPA.  1992. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSOOIETHANOLAMINE. N-                                 001116-54-7
         010144  LIJINSKY W AND RM KOVATCH.  1985.  INDUCTION  OF LIVER TUMORS IN RATS BY NITROSODIETHANOLAMINE AT LOW DOSES. CARCINOGENESIS  6  1679-1681.

                 US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR NITROSAMINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA.  1987.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSODIETHYLAMINE. N-                                   000055-18-5
         010145  PETO R.  R  GRAY.  P BRANTOM AND P  GRASSO.  1984. NITROSAMINE CARCINOGENESIS IN 5120 RODENTS.  CHRONIC  ADMINISTRATION OF 16 DIFFERENT
                 CONCENTRATIONS OF NDEA.  NDMA.  NPYR AND NPIP IN  THE WATER OF 4440 INBRED RATS.  WITH PARALLEL STUDIES ON NDEA ALONE OF THE EFFECT OF AGE OF
                 STARTING (3. 6 OR 20 WEEKS) AND  OF SPECIES  (RATS. MICE OR HAMSTERS). IARC SCI  PUBL  57.  627-665.

                 US EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR NITROSAMINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON.  DC.

                 US EPA.  1986.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
                                                                                                                                                  R3-43

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCINOGENICITY                                   May 1995



NITROSODIMETHYLAMINE.  N-                                  000062-75-9
         010146   PETO R.  R  GRAY. P BRANTQM AND P GRASSO.  1984.  NITROSAMINE CARCINOGENESIS IN 5120 RODENTS.  CHRONIC ADMINISTRATION OF 16 DIFFERENT
                 CONCENTRATIONS OF NDEA. NDMA. NPYR AND NPIP IN THE WATER OF 4440 INBRED RATS. WITH PARALLEL STUDIES  ON  NDEA ALONE OF THE EFFECT OF AGE  OF
                 STARTING (3. 6 OR 20 WEEKS) AND OF SPECIES (RATS. MICE OR HAMSTERS). IARC SCI PUBL  57. 627-665

                 US  EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US  EPA.  1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

NITROSODIPHENYLAMINE.  N-                                  000086-30-6
         005112   NCI  (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF N-NITROSODIPHENYLAMINE (CAS NO 86-30-6) FOR POSSIBLE CARCINOGENICITY. NCI
                 CARCINOGENESIS TECH REP SER NO 164. NIH 79-1720. NTIS PB 298-275.

                 US  EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US  EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR N-NITROSODIPHENYLAMINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC

                 US  EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

NITROSOMETHYLETHYLAMINE. N-                               010595-95-6
         010148   DRUCKREY H.  1967. QUANTITATIVE ASPECTS IN CHEMICAL CARCINOGENS.  IN: POTENTIAL CARCINOGENIC HAZARDS  FROM DRUGS. UICC MONOGRAPH.  SERIES  7.
                 SPRINGER-VERLAG. BERLIN. P 60-78.

                 DRUCKREY H. R PURESSMAN. S IVANKOVIC AND D SCHMAHL. 1967. ORGANOTROPIC CARCINOGENIC EFFECT OF 65 DIFFERENT N-NITROSO COMPOUNDS ON BD
                 RATS. Z  KREBSFORSCH. 69: 103-201.

                 US  EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.

                 US  EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
                                                                                                                                                  R3-44

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                                                   REFERENCES  FOR HEAST TABLE  3:  CARCINOGENICITY                                    May 1995
NITROSOMETHYLVINYLAMINE.  N                               004549-40-0
        010149  ORUCKREY H. 1967.  QUANTITATIVE ASPECTS IN CHEMICAL CARCINOGENS.  IN. POTENTIAL CARCINOGENIC HAZARDS  FROM DRUGS. UICC MONOGRAPH.  SERIES 7.
                SPRINGER-VERLAG. BERLIN.  P  60-78.

                DRUCKREY H. R PURESSMAN.  S  IVANKOVIC AND 0 SCHMAHL.  1967.  ORGANOTROPIC CARCINOGENIC EFFECT OF 65 DIFFERENT N-NITROSO COMPOUNDS  ON BD
                RATS. I KREBSFORSCH.  69:  103-201.

                US EPA. 1986. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                US EPA. 1988. EVALUATION  OF THE  POTENTIAL CARCINOGENICITY OF N-NITROSOMETHYLVINYLAMINE  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON  DC.

NITROSOPYRROLIDINE.  N-                                    000930-55-2
        010300  PREUSSMAN R. D SCHMAHL AND  G EISENBRAND. 1977  CARCINOGENICITY  OF  N-NITROSOPYRROLIDINE: DOSE-RESPONSE  STUDY  IN RATS. Z KREBSFORSCH. 90:
                161-166.

                US EPA. 1986. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP

PARATHION                                                   000056-38-2
        005116  US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR PARATHION. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA. 1987. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP

PENTABROMO-6-CHLOROCYCLOHEXANE.  1.2.3.4.5-            000087-84-3
        010150  BLAIR EH. 1981. TSCA SEC  8(E) SUBMISSION 8E HQ-0381-0393.  88-8100295 BY DOW CHEMICAL CO  OFFICE OF  TOXIC SUBSTANCES. US EPA. WASHINGTON.
                DC.

                US EPA. 1985. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR 1.2.3.4.5-PENTABROMO-6-CHLOROCYCLOHEXANE. PREPARED BY  THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON. DC.
                                                                                                                                                 R3-45

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                    May 1995




PENTACHLORONITROBENZENE                                   000082-68-8
         010151   INNES.  JRM.  BM ULLAND. MG VALERIA.  ET AL.  1969. BIOASSAY OF PESTICIDES  AND INDUSTRIAL  CHEMICALS FOR TUMORIGENICITY IN MICE- A  PRELIMINARY
                 NOTE. J NATL CANCER  INST. 41: 1101-1114.

                 US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR PENTACHLORONITROBENZENE   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE  OFFICE OF SQLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.


PENTACHLOROPHENOL                                          000087-86-5
         010381   NTP (NATIONAL TOXICOLOGY PROGRAM).  1989. TECHNICAL REPORT ON THE TOXICOLOGY  AND CARCINOGENESIS STUDIES OF PENTACHLOROPHENOL (CAS NO
                 87-86-5)  IN  B6C3F1 MICE (FEED STUDIES). NTP TECH REPORT NO 349.  NIH PUBL  NO  89-2804

                 US EPA.  1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP

PHENYLENEDIAMINE.  0-                                       000095-54-5
         010152   WEISBURGER EK. AB RUSSFIELD AND F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR
                 LONG-TERM TOXICITY OR CARCINOGENICITY.  J ENVIRON PATHOL TOXICOL.  2(2).  325-356.

                 US EPA.  1985. HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR 0-PHENYLENEDIAMINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI. OH  FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.


PHENYLPHENOL.  2-                                            000090-43-7
         010153   HIRAGA K AND U FUJII. 1981.  INDUCTION OF TUMOURS OF THE URINARY  SYSTEM  IN F344 RATS  BY DIETARY ADMINISTRATION OF SODIUM  0-PHENYLPHENATE
                 FOOD COSMET  TOXICOL.  19(3):  303-310.

                 US EPA. 1984. HEALTH AND ENVIRONMENTAL  EFFECTS  PROFILE FOR 2-PHENYLPHENOL. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC

POLYBROMINATED BIPHENYLS
         010154   NTP (NATIONAL TOXICOLOGY PROGRAM).  1983. CARCINOGENESIS STUDIES  OF POLYBROMINATED BIPHENYL MIXTURE IN F344/N RATS AND B6C3F1 MICE (GAVAGE
                 STUDIES). FIREMASTER FF-1.  CASE  NO  67774-32-7.  NTP.  RESEARCH TRIANGLE PARK.  NC

                 US  EPA.  1989. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR POLYBROMINATED BIPHENYLS  (PBBS)  PREPARED BY THE OFFICE  OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI.   OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                 RESPONSE. WASHINGTON. DC.
                                                                                                                                                 R3-46

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                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                    May 1995
POLYCHLORINATED BIPHENYLS                                001336-36-3
        005118  NORBACK. DH. AND RH WELTMAN.  1985.  POLYCHLORINATED BIPHENYL INDUCTION OF HEPATOCELLULAR  CARCINOMA  IN THE SPRAGUE-DAWLEY RAT  ENVIRON
                HEALTH PERSPECT. 60: 97-105.

                US EPA   1990  DRINKING WATER CRITERIA DOCUMENT FOR POLYCHLORINATED BIPHENYLS (PCBS)   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF DRINKING WATER. WASHINGTON. DC

                US EPA.  1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

PROPYLENE OXIDE                                            000075-56-9
        010156  DUNKELBERG  H. 1982. CARCINOGENICITY OF ETHYLENE OXIDE AND 1.2-PROPYLENE OXIDE UPON INTRAGASTRIC ADMINISTRATION TO RATS  BR J CANCER. 46.
                924-933.

                US EPA   1985  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPYLENE OXIDE  PREPARED BY  THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

                US EPA.  1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

        010155  NTP  (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY  AND  CARCINOGENESIS STUDIES OF PROPYLENE OXIDE  (CAS NO 75-56-9)  IN F344/N RATS AND
                B6C3F1 MICE (INHALATION STUDIES). NTP TECH REP SER NO. 267.  NTP. RESEARCH TRIANGLE PARK. NC  NIH  PUB  NO 85-2527.

                RENNE RA. WE GIDDENS. GA BOORMAN. R KOVATCH.  JE  HASEMAN  AND  WJ CLARKE  1986  NASAL CAVITY NEOPLASIA  IN F344/N RATS  AND (C57BL/6XC3H)F1
                MICE INHALING PROPYLENE OXIDE FOR UP TO TWO YEARS. J NATL CANCER INST  77. 573-582

                US EPA.  1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

QUINOLINE                                                    000091-22-5
        010158  HIRAO K. Y  SHINOHARA. H TSUDA. ET AL. 1976. CARCINOGENIC ACTIVITY  OF QUINOLINE ON RAT LIVER  CANCER RES.  36.  329-335

                US EPA   1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR QUINOLINE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON.  DC.
                                                                                                                                                   R3-47

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                                                    REFERENCES FOR HEAST TABLE  3:  CARCINOGENICITY
Nay 1995
RDX /  (CYCLONITE)                                           000121-82-4
         010157   LISH  PM. BS LEVINE. EM FUREDI. EM SAGARTZ AND  VS RAC. 1984. DETERMINATION OF THE CHRONIC MAMMALIAN TOXICOLOGICAL EFFECT OF RDX: TWENTY
                 FOUR  MONTH CHRONIC TOXICITY/CARCINOGENICITY STUDY OF HEXAHYDRA-1.2.5-TRINITRO-1.3.5-TRIAZINE  (RDX) IN THE B6C3F1 HYBRID MOUSE.  PHASE VI.
                 VOL 1.  ITT RESEARCH INSTITUTE. CHICAGO.  IL.  US ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND.  CONTRACT NO. DAMD 17-79-C-9161.  NTIS
                 AD-A181766.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR RDX (CYCLONITE). PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA.  1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

SELENIUM SULFIDE                                            007446-34-6
         010194   NCI/NTP (NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM). 1980. BIOASSAY OF  SELENIUM SULFIDE (GAVAGE) FOR POSSIBLE
                 CARCINOGENICITY. NCI TECHNICAL REPORT SERIES NO. 194. NTP NO. 80-17.

                 US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELENIUM AND COMPOUNDS.  PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US EPA.  1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

SIMAZINE                                                     000122-34-9
         010195   US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SIMAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.  DC.

                 US EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

SODIUM  DIETHYLblTHIOCARBAMATE                            000148-18-5
         005126   BRL (BIONETICS RESEARCH LABORATORIES).  1968 EVALUATION OF CARCINOGENIC TERATOGENIC AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES  ON
                 INDUSTRIAL CHEMICALS.  VOL.  I. CARCINOGENIC STUDY. PREPARED FOR NATIONAL CANCER INSTITUTE  US  DEPT COMMERCE. NAT TECH INFO SERV.
                 WASHINGTON. DC NTIS PB223159.

                 US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SODIUM DIETHYLDITHIOCARBAMATE.  PREPARED BY THE OFFICE OF HEALTH AND
                 ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                 RESPONSE. WASHINGTON.  DC.

STYRENE                                                       000100-42-5
         010480   CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
                                                                                                                                                  R3-48

-------
                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGEN1CITY                                    May 1995



TCDD. 2.3.7.8-                                             001746-01-6
         005128  KOCIBA.  RJ. DG KEYES. JE BOWER ET AL.  1978. RESULTS OF A TWO-YEAR CHRONIC TOXICITY AND ONCOGENICITY STUDY OF
                 2.3.7.8-TETRACHLOROOIBENZO-P-DIOXIN  IN RATS  TOXICOL APPL PHARMACOL  46(2).  279-303

                 US EPA.  1985. HEALTH ASSESSMENT DOCUMENT  FOR POLYCHLORINATED DIBENZO-P-DIOXIN   PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH.  EPA  600/8-84-014F  NTIS PB86-122546

                 US EPA.  1984. HEALTH EFFECTS ASSESSMENT FOR 2.3.7.8-TCDD. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC.

                 US EPA.  1989. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP

TETRACHLOROETHANE.  1.1.1.2-                              000630-20-6
         010302  NTP (NATIONAL TOXICOLOGY PROGRAM). 1983.  CARCINOGENESIS STUDIES OF l.i,1.2-TETRACHLOROETHANE (CAS NO 630-20-6) IN F344/N  RATS AND B6C3F1
                 MICE (GAVAGE STUDIES).  NTP-81-53.  NIH  PUBL NO 83-1793. NTP TECHNICAL REPORT  SERIES NO 237. NTIS. SPRINGFIELD. VA.

                 US EPA.  1988. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP.

                 US EPA.  1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR 1.1.1.2-TETRACHLOROETHANE  PREPARED  BY THE
                 OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE  OF WATER.
                 WASHINGTON. DC.

TETRACHLOROETHANE.  1.1.2.2-                              000079-34-5
         005130  NCI  (NATIONAL CANCER INSTITUTE).  1978.  BIOASSAY OF 1.1.2.2-TETRACHLOROETHANE FOR  POSSIBLE CARCINOGEN1C1TY. NCI CARCINOGENESIS TECH REP
                 SER NO 27. DHEW NO (NIH) 78-827.

                 US EPA.  1980. AMBIENT WATER QUALITY  CRITERIA DOCUMENT FOR CHLORINATED ETHANES   PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE  OFFICE  OF WATER REGULATIONS AND STANDARDS.  WASHINGTON.
                 DC.

                 US EPA.  1986. CARCINOGEN RISK ASSESSMENT  VERIFICATION ENDEAVOR (CRAVE)  WORK  GROUP

TETRACHLOROETHYLENE                                       000127-18-4
         010482  CONTACT  THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300
                                                                                                                                                  R3-49

-------
                                                    REFERENCES FOR  HEAST TABLE 3:   CARCINOGENICITY                                    May  1995
TETRACHLOROTOLUENE.  PARA. ALPHA.  ALPHA.  ALPHA-       005216-25-1
        005028  FUKADA. KS. MATSASHITA AND K TAKEMOTO.  1979. CARCINOGENICITY OF P-CHLOROBENZOTRICHLORIDE  PROC OF JAPAN ASSOC OF  IND  HEALTH  P 330-331.

                US EPA  1987. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR SELECTED CHLORINATED TOLUENES  PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE  AND  EMERGENCY
                RESPONSE. WASHINGTON. DC.

TETRACHLOROVINPHOS /  (STIROFOS)                          000961-11-5
        010159  NCI  (NATIONAL CANCER INSTITUTE).  1978.  BIOASSAY OF TETRACHLOROVINPHOS FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH REP SER NO. 33
                NTIS PB278650.

                US EPA  1984  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR STIROFOS.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

TOLUENE-2.4-DIAMINE                                       000095-80-7
        010160  NCI  (NATIONAL CANCER INSTITUTE).  1979  BIOASSAY OF 2.4-DIAMINOTOLUENE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH REP SER NO. 162.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR 2.4-TOLUENEDIAMINE   PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE.
                WASHINGTON. DC.

TOLUIDINE. P-                                               000106-49-0
        010162  WEISBURGER EK. AB RUSSFIELD AND F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR  DERIVATIVES FOR
                LONG-TERM TOXICITY OR CARCINOGENICITY.  J ENVIRON PATHOL TOXICOL. 2(2).  325-356

                US EPA. 1984. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR TOLUIDINES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE,  WASHINGTON, DC.

TOXAPHENE                                                   008001-35-2
        005134  LITTON  BIONETICS. INC. 1978. CARCINOGENIC  EVALUATION IN MICE: TOXAPHENE  PREPARED BY LITTON BIONETICS. INC.. KENSINGTON.  MD FOR HERCULES.
                INC.  WILMINGTON. DE. LBI PROJECT NO.  20602.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TOXAPHENE  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL
                CRITERIA  AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.

                US EPA  1980  AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR TOXAPHENE.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF WATER REGULATIONS AND STANDARDS. WASHINGTON. DC.

                US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP.


                                                                                                                                                  R3-50

-------
                                                    REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                   May 1995




 TRICHLOROANILINE HYDROCHLORIDE.  2.4.6-                 033663-50-2
         005142  WEISBURGER.  EL. AB RUSSFIELD. R HOMBURGER.  ET AL  1978. TESTING OF 21 ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM TOXICITY
                 OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2- 325-356.


                 US EPA.  1987. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR TRICHLOROANILINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.


 TRICHLOROANILINE.  2.4.6-                                 000634-93-5
         010487  WEISBURGER.  EL. AB RUSSFIELD. F HOMBURGER.  ET AL. 1978. TESTING OF 21 ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG TERM TOXICITY
                 OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.


                 US EPA.  1987. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR TRICHLOROANILINES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
                 WASHINGTON.  DC.


TRICHLOROETHANE.  1.1.2-                                   000079-00-5
         005144  NCI  (NATIONAL CANCER INSTITUTE).  1978.  BIOASSAY OF 1.1.2-TRICHLOROETHANE  FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER  NO
                 74. DHEW NO  NIH 78-1324.


                 US EPA.  1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED ETHANES  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT.  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI.  OH  FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS  WASHINGTON
                 DC.


                 US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1.1.2-TRICHLOROETHANE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC. '

                 US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP


TRICHLOROETHYLENE                                          000079-01-6
         010483   CONTACT THE SUPERFUND HEALTH RISK  TECHNICAL SUPPORT CENTER:  (513)  569-7300
                                                                                                                                                 R3-51

-------
                                                    REFERENCES FOR HEAST TABLE  3:   CARCINOGENICITY
                                                                                              Hay 1995
TRICHLOROPHENOL.  2.4.6-
        010428   NCI  (NATIONAL CANCER INSTITUTE).
                 155. OHEW NO NIH 79-1711.
              000088-06-2
1979.  BIOASSAY OF 2.4.6-TRICHLOROPHENOL FOR POSSIBLE CARCINOGENICITY.
NCI CARCINOGENESIS TECH  REP SER NO
                 US  EPA   1980  AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
                 DC.

                 US  EPA   1984  HEALTH EFFECTS ASSESSMENT FOR 2.4.6-TRICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE. WASHINGTON. DC.

                 US  EPA   1987  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR CHLORINATED PHENOLS  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                 ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                 WASHINGTON. DC.

                 US  EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION  ENDEAVOR  (CRAVE) WORK GROUP.

TRICHLOROPROPANE.  1.2,3-                                  000096-18-4
         010849  NTP (NATIONAL TOXICOLOGY PROGRAM). 1991. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF  1.2.3-TRICHLOROPROPANE  (CAS
                 NO  96-18-4)  IN  F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). BOARD DRAFT NTP TR 384  NIH PUB NO 91-2839  US DEPT OF HEALTH AND HUMAN
                 SERVICES.  PUBLIC HEALTH SERVICE. NIH. RESEARCH TRIANGLE  PARK. NC.

                 US  EPA.  1993. CARCINOGEN RISK ASSESSMENT VERIFICATION  ENDEAVOR  (CRAVE) WORK GROUP

TRIFLURALIN                                                 001582-09-8
         010163  EMMERSON JL   EC PIERCE  JP MCGRATH. ET AL. 1980.  THE CHRONIC TOXICITY OF COMPOUND 36352 (TRIFLURALIN)  GIVEN AS A COMPOUND OF  THE  DIET TO
                 FISCHER 344  RATS FOR TWO YEARS. STUDIES R-87 AND R-97  (UNPUBLISHED STUDY RECEIVED SEPTEMBER 18. 1980 UNDER 1471-35. SUBMITTED BY  ELANCO
                 PRODUCTS CO.. DIVISION OF ELI LILLY AND CO.. INDIANAPOLIS.  IN).

                 US  EPA  1984  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  TRIFLURALIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US  EPA.  1987. CARCINOGEN RISK ASSESSMENT VERIFICATION  ENDEAVOR  (CRAVE) WORK GROUP.
                                                                                                                                                   R3-52

-------
                                                   REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                                    May 1995
TRIMETHYL PHOSPHATE                                       000512-56-1
        010164  NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF  TRIMETHYLPHOSPHATE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH  REP SER NO. 81.

                US EPA. 1985. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR TRIMETHYL PHOSPHATE  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

TRINITROTOLUENE. 2.4.6-                                   000118-96-7
        010476  US DOD (DEPARTMENT OF DEFENSE). 1984. AD-A168637. DEFENSE TECHNICAL CENTER.  CAMERON STATION. ALEXANDRIA. VA.

                US EPA. 1990. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT  FOR  2.4.6-TRINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON. DC.

                US EPA. 1988. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
                                                                                                                                                 R3-53

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                                                    REFERENCES  FOR  HEAST TABLE 3:   CARCINOGENICITY                                    May  1995
VINYL CHLORIDE                                              000075-01-4
         010368   FERON.  VJ. CFM HENORIKSEN. AJ SPEEK. ET AL.  1981.  LIFESPAN ORAL TOXICITY STUDY  OF  VINYL  CHLORIDE  IN RATS. FOOD COSMET TOXICOL. 19(3):
                 317-333.

                 US  EPA  1984  HEALTH  EFFECTS ASSESSMENT FOR VINYL CHLORIDE. PREPARED BY THE OFFICE OF  HEALTH AND  ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
                 CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.  OH FOR THE OFFICE OF EMERGENCY AND  REMEDIAL  RESPONSE. WASHINGTON. DC.

                 US  EPA  1985  DRINKING WATER CRITERIA DOCUMENT FOR VINYL CHLORIDE.  PREPARED BY  THE OFFICE  OF HEALTH AND  ENVIRONMENTAL ASSESSMENT,
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI OH FOR THE OFFICE OF DRINKING WATER.  WASHINGTON. DC.

                 US  EPA.  1990. CARCINOGEN  RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

         010367   MALTONI C G LEFEMINE  A CILIBERTI ET AL  1980  VINYL CHLORIDE CARCINOGENICITY BIOASSAYS  (BT  PROJECT) AS AN EXPERIMENTAL MODEL  FOR RISK
                 IDENTIFICATION AND ASSESSMENT  IN ENVIRONMENTAL AND OCCUPATIONAL CARCINOGENESIS   EPIDEMIOL  ANIM EPIDEMIOL HUM: CAS  CHLORURE VINYLE
                 MONOMERE.  (REUN  CLUB  CANCEROG CHIM). 20TH. MEETING DATE 1979. P. 11-112  PUBL ESSENT.  PARIS. FRANCE.

                 MALTONI. C. G LEFEMINE. A CILIBERTI ET AL. 1981  CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE MONOMER. A  MODEL OF RISK ASSESSMENT ON AN
                 EXPERIMENTAL BASIS. ENVIRON HEALTH  PERSPECT  41: 329.

                 US  EPA  1985  HEALTH  AND  ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROETHENE. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT.
                 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE.  WASHINGTON. DC.

                 US  EPA. 1990. CARCINOGEN  RISK  ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP

                 US  EPA. 1994. CARCINOGEN  RISK  ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
                                                                                                                                                    R3-54

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                             Table 4

         Radionuclide Carcinogencity - Slope Factors
                     (In Units of Picocuries)

                            MAY 1995
NOTE: To convert radionuclide slope factors into the International System (SI)
activity units of becquerels (Bq), multiply each value in Table 4 by 3.70E-02.

-------
                    Table 4: Radionuclide Carcinogenicity -- Slope Factors3     MAY 1995
                                     (In Units of Picocuriesb)
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Actinium (89)



Americium (95)




Antimony (51)







Argon (18)
Isotope'
Ac-225
Ac-227
Ac-227+D
Ac-228
Am-241
Am-242
Am-242m
Am-243
Am-243+D
Sb-122
Sb-124
Sb-125
Sb-125+D
Sb-126
Sb-126m
Sb-127
Sb-129
Ar-41
CASRN*
014265-85-1
014952-40-0
014952-40-0(^0)
014331-83-0
014596-10-2
013981-54-9
013981-54-9(m)
014993-75-0
014993-75-0(+D)
014374-79-9
014683-10-4
014234-35-6
014234-35-6(+D)
015756-32-8
015756-32-8(m)
013968-50-8
014331-88-5
014163-25-8
Radioactive
Hart-life*
1.00E+01
2.18E+01
2.18E+01
6.13E+00
4.32E+02
1.60E+01
1.52E+02
7.38E+03
7.38E+03
2.70E+00
6.02E+01
2.77E+00
2.77E+00
1.24E+01
1.90E+01
3.85E+00
4.40E+00
1.83E+00
D
Y
Y
H
Y
H
Y
Y
Y
D
D
Y
Y
D
M
D
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
W
W
W
*
Gl
Absorption
Factor (f,)s
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
—
Ingestion
(Risk/pCi)
1.42E-10
352E-10
6.26E-10
1 62E-12
3.28E-10
1 47E-12
2 92E-10
3 27E-10
3.31E-10
8.81E-12
1.07E-11
2.97E-12
354E-12
9.73E-12
7.28E-14
8.48E-12
1 86E-12
—
Inhalation
(Risk/pCi)
4.16E-09
7.08E-08
7.87E-08
3.27E-11
3.85E-08
1.04E-11
3.49E-08
3.82E-08
3.82E-08
5.46E-12
1.32E-11
5.20E-12
5.85E-12
8.41 E-1 2
6.43E-14
6.05E-12
8.60E-13
4.71E-16
External Exposure
(Risk/yr per pCI/g soil)
7.81 E-09
2.35E-11
5.97E-07
3.28E-06
4.59E-09
5 76E-09
8.76E-11
2.43E-08
2.66E-07
1.61E-06
7.35E-06
1.34E-06
1.34E-06
1 .03E-05
5.78E-06
2.40E-06
5.56E-06
—
[Table 4 continues on the following page: Refer to Endnotes on the last page.]

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors2
                                     (In Units of Picocuriesb)
MAY 1995
Element
(Atomic Number)
Astatine (85)
Barium (56)





Beryllium (4)
Bismuth (83)






Bromine (35)
Cadmium (20)

Isotope0
At-217
Ba-131
Ba-133
Ba-133m
Ba-137m
Ba-139
Ba-140
Be-7
Bi-206
Bi-207
Bi-210
Bi-211
Bt-212
Bi-213
Bi-214
Br-82
Cd-109
Cd-115
CASRN"
017239-90-6
014914-75-1
013981-41-4
013981-41-4(m)
013981-97-0(m)
014378-25-7
0147984)8-4
0139664)2-4
015776-19-9
013982-38-2
014331-79-4
015229-37-5
014913-494)
015776-20-2
014733-03-0
014686-69-2
014109-32-1
014336-68-6
Radioactive
Half-life*
3.23E-02
1.18E+01
1.05E+01
3.89E+01
2.55E+00
8.31 E+01
1.28E+01
5.34E+01
6.24E+00
3.34E+01
5.01 E+00
2.13E+00
6.06E+01
4.57E+01
1.99E+01
3.53E+01
4.64E+02
5.35E+01
S
D
Y
H
M
M
D
D
D
Y
D
M
M
M
M
H
D
H
ICRP
Lung
Class'
0
0
D
D
D
D
D
Y
W
W
W
W
W
W
W
D
Y
Y
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Gl
Absorption
Factor (f,)8
9.50E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
1.00E-01
5.00E-03
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
9.50E-01
5.00E-02
5.00E-02
Ingestion
(Risk/pCi)
899E-18
1 70E-12
2 70E-12
2 76E-12
243E-15
3.04E-13
1 18E-11
8.64E-14
7.11E-12
5.05E-12
7.29E-12
1.82E-14
620E-13
440E-13
1.95E-13
1.42E-12
8.01E-12
7 29E-12
Inhalation
(Risk/pCi)
5.14E-16
4.79E-13
4.03E-12
5.60E-13
1.57E-15
1.53E-13
3.17E-12
1.78E-13
5.07E-12
9.42E-12
5.12E-11
1.74E-12
3.65E-11
3.09E-1 1
1.46E-11
7.86E-13
1.85E-11
4.93E-12
External Exposure
(Risk/yr per pCi/g soil)
8.71E-10
1 27E-06
9 15E-07
1 .OOE-07
221E-06
8.35E-08
6.00E-07
1.73E-07
1.20E-05
5.49E-06
O.OOE+0
1 48E-07
6.67E-07
4.62E-07
6 02E-06
101E-05
5.62E-10
7.02E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors8
                                     (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)

Calcium (20)

Carbon (6)


Cerium (58)



Cesium (55)







Isotope0
Cd-115m
Ca-45
Ca-47
C-11
C-14
C-15
Ce-141
Ce-143
Ce-144
Ce-144+D
Cs-131
Cs-134
Cs-134m
Cs-135
Cs-136
Cs-137
Cs-137+D
Cs-138
CASRN"
014336-68-6(m)
013966-05-7
001439-99-2
014333-33-6
014762-75-5
015929-23-4
013967-74-3
014119-19-8
014762-78-8
014762-78-8(+D)
014914-76-2
013967-70-9
013967-70-9(m)
015726-30-4
014234-29-8
010045-97-3
010045-97-3(+D)
015758-29-9
Radioactive
Half-life*
4.46E+01
1.63E+02
4.54E+00
2.05E+01
5.73E+03
2.45E+00
3.25E+01
3.30E+01
2.84E+02
2.84E+02
9.69E+00
2.06E+00
2.90E+00
2.30E+06
1.32E+01
3.02E+01
3.02E+01
3.22E+01
D
D
D
M
Y
S
D
H
D
D
D
Y
H
Y
D
Y
Y
M
ICRP
Lung
Class'
Y
W
W
D
*
D
Y
Y
Y
Y
D
D
O
D
D
D
D
D
Gl
Absorption
Factor (f,)g
5.00E-02
3.00E-01
3.00E-01
9.50E-01
1.00E+00
- 9.50E-01
3.00E-04
3.00E-04
3.00E-04
3.00E-04
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
Ingestion
(Risk/pCi)
1.42E-11
2.02E-12
6.66E-12
4.49E-14
1.03E-12
6 62E-16
391E-12
591E-12
2 96E-1 1
2 97E-1 1
1 80E-13
4 73E-1 1
4.54E-14
4.53E-12
7.74E-12
3.16E-11
316E-11
1.76E-13
Inhalation
(Risk/pCi)
1.70E-11
2.51E-12
5.22E-12
3.38E-14
6.99E-15
8.06E-16
4.32E-12
3.84E-12
1.08E-10
1.08E-10
1.06E-13
2.89E-1 1
3.10E-14
2.71E-12
4.65E-12
1.91E-11
1.91E-11
1.30E-13
External Exposure
(Risk/yr per pCi/g soil)
8.55E-08
388E-18
4.12E-06
3.61 E-06
OOOE+0
—
1.41E-07
7.32E-07
2.58E-08
1.56E-07
2.34E-09
5.88E-06
1.96E-08
O.OOE+0
8.13E-06
O.OOE+0
2.09E-06
9.45E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page.]

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors8
                                     (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Chlorine (17)

Chromium (24)
Cobalt (27)



Copper (29)
Curium (96)







Dysprosium (66)

Isotope0
CI-36
CI-38
Cr-51
Co-57
Co-58
Co-58m
Co-60
Cu-64
Cm-242
Cm-243
Cm-243+D
Cm-244
Cm-245
Cm-246
Cm-247
Cm-248
Dy-165
Dy-166
CASRN"
013981-43-6
014158-34-0
014392-02-0
013981-50-5
01381-38-9
01381-38-9(m)
010198-40-0
013981-25-4
015510-73-3
015757-87-6
015757-87-6(+D)
013981-15-2
015621-76-8
015757-90-1
015758-32-4
015758-33-5
013967-64-1
015840-01-4
Radioactive
Half-life*
3.01 E+05
3.72E+01
2.77E+01
2.71 E+02
7.08E+01
9.15E+00
5.27E+00
1.27E+01
1.63E+02
2.85E+01
2.85E+01
1.81E+01
8.50E+03
4.75E+03
1.56E+07
3.39E+05
2.33E+00
8.16E+01
Y
M
D
D
D
H
Y
H
D
Y
Y
Y
Y
Y
Y
Y
H
H
ICRP
Lung
Class*
D
D
Y
Y
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)B
9.50E-01
9.50E-01
1.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
5.00E-01
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
3.00E-04
3.00E-04
Ingestion
(Risk/pCi)
2.23E-12
2 07E-13
1 38E-13
9.71E-13
282E-12
9.46E-14
1.89E-11
525E-13
383E-11
251E-10
2.52E-10
2.11E-10
3.35E-10
3.32E-10
309E-10
1 31E-09
3.26E-13
9.42E-12
Inhalation
(Risk/pCi)
1.30E-12
1.63E-13
1.74E-13
2.88E-12
5.17E-12
8.90E-14
6.88E-11
4.18E-13
3.16E-09
2.89E-08
2.90E-08
2.43E-08
3.92E-08
3.90E-08
3.58E-08
1.46E-07
2.24E-13
7.82E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
6.47E-06
1.02E-07
2.07E-07
3.73E-06
3.21E-11
976E-06
6.72E-07
2.34E-11
1.71E-07
1.72E-07
2.07E-11
5.51 E-08
1.81E-11
1.03E-06
1.47E-11
6.18E-08
2.72E-08
[Table 4 continues on the following page: Refer to Endnotes on the last page.]

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors3
                                     (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Erbium (63)

Europium (63)



Fluorine (9)
Francium (87)

Gadolinium (64)

Gallium (31)

Germanium (32)
Gold (79)

Holmium (67)
Hydrogen (1)
Isotope'
Er-169
Er-171
Eu-152
Eu-154
Eu-155
Eu-156
F-18
Fr-221
Fr-223
Gd-153
Gd-159
Ga-67
Ga-72
Ge-71
Au-196
Au-198
Ho-166
H-3
CASRN"
015840-13-8
014391-45-8
014683-23-9
015585-10-1
014391-16-3
014280-35-4
013981-56-1
015756-41-9
015756-98-6
014276-65-4
014041-42-0
014119-09-6
013982-22-4
014374-81-3
014914-16-0
010043-49-0
013967-65-2
010028-17-8
Radioactive
Half-life*
9.40E+00
7.52E+00
1.36E+01
8.80E+00
4.96E+00
1.52E+01
1.10E+02
4.80E+00
2.18E+00
2.42E+02
1.86E+01
3.26E+00
1.41E+01
1.18E+01
6.18E+00
2.70E+00
2.68E+01
1.23E+01
D
H
Y
Y
Y
D
M
M
M
D
H
D
H
D
D
D
H
Y
ICRP
Lung
Class*
W
W
W
W
W
W
D
D
D
W
W
W
W
W
Y
Y
W
V
Gl
Absorption
Factor (f,)9
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1.00E-03
1.00E-03
9.50E-01
9.50E-01
9.50E-01
3.00E-04
3.00E-04
1.00E-03
1.00E-03
9.50E-01
1.00E-01
1.00E-01
3.00E-04
1.00E+00
IngesUon
(Risk/pCi)
2.12E-12
1 63E-12
5 73E-12
9 37E-12
1.65E-12
1.09E-11
1.09E-13
1.45E-13
4.46E-13
1.32E-12
2.60E-12
8.36E-13
4 77E-12
1.18E-14
130E-12
528E-12
7 57E-12
7.15E-14
Inhalation
(Risk/pCi)
1.51E-12
7.50E-13
7.91 E-11
9.15E-11
9.60E-12
9.26E-12
6.54E-14
8.02E-12
5.90E-13
3.20E-12
1.24E-12
5.14E-13
2.17E-12
5.84E-14
1.04E-12
3.64E-12
4.06E-12
9.59E-14
External Exposure
(Risk/yr per pCI/g soil)
6.52E-12
1.04E-06
4.08E-06
4.65E-06
6.08E-08
5.40E-06
3.50E-06
6.74E-08
4.17E-08
7.22E-08
9.59E-08
3.61 E-07
1.12E-05
1.56E-11
1.41E-06
1.37E-06
6.96E-08
O.OOE+0
(Table 4 continues on the following page: Refer to Endnotes on the last page.]

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors8     MAY 1995
                                     (In Units of Picocuries5)
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Indium (49)




Iodine (53)










Indium (77)

Isotope0
ln-1 13m
ln-114
ln-114m
ln-115
ln-115m
1-122
1-123
1-125
1-126
1-129
1-130
1-131
1-132
1-133
1-134
1-135
lr-190
lr-194
CASRN"
014885-78-0(m)
013981-55-0
013981-55-0(m)
014191-71-0
014191-71-0(m)
018287-75-7
015715-08-9
014158-31-7
014158-32-8
015046-84-1
014914-02-4
010043-66-0
014683-16-0
014834-67-4
014914-27-3
014834-68-5
014981-91-0
014158-35-1
Radioactive
Half-life*
1.66E+00
7.19E+01
4.95E+01
4.606+15
4.36E+00
3.62E+00
1.31E+01
6.01 E+01
1.29E+01
1.57E+07
1.24E+01
8.04E+00
2.30E+00
2.08E+01
5.26E+01
6.61 E+00
1.18E+01
1.92E+01
H
S
D
Y
H
M
H
D
D
Y
H
D
H
H
M
H
D
H
ICRP
Lung
Class'
W
W
W
W
W
D
D
D
D
D
D
D
D
D
D
D
Y
Y
Gl
Absorption
Factor (f,)8
2.00E-02
2.00E-02
2.00E-02
200E-02
2.00E-02
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
1.00E-02
1.00E-02
Ingestion
(Risk/pCi)
8 30E-14
4.53E-15
206E-11
349E-11
3.42E-13
2.16E-14
5.42E-13
2.58E-11
4.82E-11
1.84E-10
4.85E-12
362E-11
6.62E-13
106E-11
2.31E-13
2.27E-12
4 95E-12
7 OOE-12
Inhalation
(Risk/pCi)
5.77E-14
5.81E-15
2.53E-11
2.07E-10
1.75E-13
2.24E-14
2.94E-13
1.71E-11
3.15E-11
1.22E-10
2.61E-12
2.33E-11
3.52E-13
6.02E-12
1.38E-13
1.18E-12
4.49E-12
4.18E-12
External Exposure
(Risk/yr per pCi/g soil)
7.82E-07
1.13E-07
200E-07
O.OOE+0
4.29E-07
341E-06
2.52E-07
2.39E-09
1.49E-06
2.69E-09
7.93E-06
1.25E-06
8.75E-06
220E-06
1.02E-05
6.23E-06
4.65E-06
3.17E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors8
                                     (In Units of Picocuriesb)
MAY 1995
Element
(Atomic Number)
Iron (26)

Krypton (36)






Lanthanum (57)
Lead (82)






Lutetium(71)
Isotope0
Fe-55
Fe-59
Kr-83m
Kr-85
Kr-85m
Kr-87
Kr-88
Kr-89
Kr-90
La-140
Pb-203
Pb-209
Pb-210
Pb-210+D
Pb-211
Pb-212
Pb-214
Lu-177
CASRN"
014681-59-5
014596-12-4
013965-98-5(m)
013983-27-2
013983-27-2(m)
014809-68-8
014995-61-0
016316-03-3
015741-13-6
013981-28-7
014687-25-3
014119-30-3
014255-04-0
014255-04-0(+D)
015816-77-0
015092-94-1
015067-28-4
014265-75-9
Radioactive
Half-life*
2.70E+00
4.46E+01
1.83E+00
1.07E+01
4.48E+00
7.63E+01
2.84E+00
3.16E+00
3.23E+01
4.02E+01
5.20E+01
3.25E+00
2.23E+01
2.23E+01
3.61 E+01
1.06E+01
2.68E+01
6.71 E+00
Y
D
H
Y
H
M
H
M
S
H
H
H
Y
Y
M
H
M
D
ICRP
Lung
Class'
W
w
*
*
*
*
*
*
*
w
D
D
D
D
D
D
D
Y
Gl
Absorption
Factor (f,)a
1.00E-01
1.00E-01
--
—
--
--
—
--
—
1.00E-03
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
3.00E-04
Lifetime Excess
Ingestion
(Risk/pCi)
351E-13
5 87E-12
—
—
—
—
—
—
—
9.46E-12
1.03E-12
2.09E-13
6.75E-10
1 01E-09
338E-13
180E-11
294E-13
2.95E-12
Slope Factor
Total Cancer Risk Per Unit Intake or Exposure
Inhalation
(Risk/pCi)
5.60E-13
7.08E-12
3.48E-17
2.87E-16
2.75E-16
1.20E-15
2.20E-15
1.61E-15
1.60E-15
5.10E-12
3 10E-13
6.85E-14
1.67E-09
3.86E-09
1.03E-11
3.85E-11
6.23E-12
2.20E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
4 63E-06
—
—
—
—
--
--
_
9.11E-06
6.40E-07
O.OOE+0
1.12E-10
1.45E-10
1.85E-07
3.00E-07
7.09E-07
7.22E-08
[Table 4 continues on the following page: Refer to Endnotes on the last page.]

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors8
                                     (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Manganese (25)


Mercury (80)

Molybdenum (42)
Neodymium (60)

Neptunium (93)






Nickel (28)


lsotopec
Mn-52
Mn-54
Mn-56
Hg-197
Hg-203
Mo-99
Nd-147
Nd-149
Np-236
Np-237
Np-237+D
Np-238
Np-239
Np-240
Np-240m
Ni-59
Ni-63
Ni-65
CASRN"
014092-99-0
013966-31-9
014681-52-8
013981-51-6
013982-78-0
014119-15-4
014269-74-0
015749-81-2
015700-36-4
013994-20-2
013994-20-2(+D)
015766-25-3
013968-59-7
015690-84-3
015690-84-3(m)
014336-70-0
013981-37-8
014833-49-9
Radioactive
Half-life*
5.59E+00
3.13E+02
2.58E+00
6.41 E+01
4.66E+01
6.60E+01
1.10E+01
1.73E+00
1.15E+05
2.14E+06
2.14E+06
2.12E+00
2.36E+00
6.50E+01
7.40E+00
7.50E+04
1.00E+02
2.52E+00
D
D
H
H
D
H
D
H
Y
Y
Y
D
D
M
M
Y
Y
H
ICRP
Lung
Class'
W
W
W
W
W
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)fl
1.00E-01
1.00E-01
1.00E-01
2.00E-02
2.00E-02
8.00E-01
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
5.00E-02
5.00E-02
5.00E-02
Ingestion
(Risk/pCi)
601E-12
1.96E-12
8.57E-13
1.18E-12
2.64E-12
2.27E-12
5.88E-12
4.55E-13
9.31E-13
2.95E-10
3.00E-10
4.56E-12
427E-12
1 77E-13
242E-14
1.85E-13
5.50E-13
562E-13
Inhalation
(Risk/pCi)
4 40E-12
3.69E-12
5.21E-13
6.95E-13
3.03E-12
4.48E-12
4.84E-12
4.22E-13
3.87E-12
3.45E-08
3.45E-08
4.68E-12
2.41E-12
1.31E-13
2.83E-14
4.01E-13
1.01E-12
3.59E-13
External Exposure
(Risk/yr per pCI/g soil)
1.34E-05
3.26E-06
6.95E-06
5.47E-08
6.27E-07
5.46E-07
3.22E-07
1.08E-06
922E-08
7.56E-09
4.62E-07
1.95E-06
2.42E-07
365E-06
1 05E-06
O.OOE+0
O.OOE+0
2.14E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page ]

-------
                    Table 4: Radionuclide Carcinogenicity -- Slope Factors8
                                     (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Niobium (41)





Osmium (76)



Palladium (46)




Phosphorus (15)

Platinum (78)
Isotope0
Nb-93m
Nb-94
Nb-95
Nb-95m
Nb-97
Nb-97m
Os-185
Os-191
Os-191m
Os-193
Pd-100
Pd-101
Pd-103
Pd-107
Pd-109
P-32
P-33
Pt-191
CASRN"
007440-03-1(m)
014681-63-1
013967-76-5
013967-76-5(m)
018496-04-3
018496-04-3(m)
015766-50-4
014119-24-5
014119-24-5(m)
016057-77-5
015690-69^1
015749-54-9
014967-68-1
017637-99-9
014981-64-7
014596-37-3
015749-66-3
015706-36-2
Radioactive
Half-life*
1.46E+01
2.03E+04
3.51 E+01
8.66E+01
7.21 E+01
6.00E+01
9.36E+01
1.54E+01
1.30E+01
3.00E+01
3.64E+00
8.48E+00
1.70E+01
6.50E+06
1.35E+01
1.43E+01
2.54E+01
2.71 E+00
Y
Y
D
H
M
S
D
0
H
H
D
H
D
Y
H
D
D
O
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
D
D
D
Gl
Absorption
Factor (f,)a
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-02
5.00E-03
5.00E-03
5.00E-03
5.00E-03
5.00E-03
8.00E-01
8.00E-01
1.00E-02
Ingestion
(Risk/pCi)
6.64E-13
691E-12
2.25E-12
3.06E-12
1.75E-13
327E-15
1.80E-12
3.04E-12
4 95E-13
4 36E-12
3 74E-12
3 74E-13
1.05E-12
2 09E-13
3.33E-12
611E-12
781E-13
1 50E-12
Inhalation
(Risk/pCi)
4.33E-12
8.20E-11
3.11E-12
2.25E-12
2.13E-13
3.34E-15
4.62E-12
2.70E-12
3.32E-13
2.68E-12
3.55E-12
2.29E-13
1.08E-12
1.46E-12
1.99E-12
2.93E-12
3.96E-13
4.13E-13
External Exposure
(Risk/yr per pCI/g soil)
3.64E-11
6.08E-06
2.94E-06
8.71 E-08
2.49E-06
2.78E-06
2.45E-06
8.74E-08
3.22E-09
1 .82E-07
_.
_
5.38E-10
O.OOE+0
2 43E-09
O.OOE+0
0 OOE+0
6.74E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
              10

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors3
                                     (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Pt-193
Pt-193m
Pt-197
Pt-197m
Plutonium (94) Pu-236
Pu-238
Pu-239
Pu-240
Pu-241
Pu-241+D
Pu-242
Pu-243
Pu-244
Pu-244+D
Polonium (84) Po-210
Po-212
Po-213
Po-214
CASRN"
015735-70-3
015735-70-3(m)
015735-74-7
015735-74-7(m)
015411-92-4
013981-16-3
015117-48-3
014119-33-6
014119-32-5
014119-32-5(+D)
013982-10-0
015706-37-3
014119-34-7
014119-34-7(+D)
013981-52-7
015389-34-1
015756-57-7
01573W7-8
Radioactive
Half-life*
5.00E+01
4.33E+00
1.83E+01
9.44E+01
2.85E+00
8.78E+01
2.41 E+04
6.57E+03
1.44E+01
1.44E+01
3.76E+05
4.96E+00
8.26E+07
8.26E+07
1.38E+02
2.98E-07
4.20E-06
1.64E-04
Y
D
H
M
Y
Y
Y
Y
Y
Y
Y
H
Y
Y
D
S
S
S
ICRP
Lung
Class'
D
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
W
61
Absorption
Factor (f,)a
1.00E-02
1.00E-02
1.00E-02
1.00E-02
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1.00E-01
1.00E-01
1.00EX)1
1.00E-01
Ingestion
(Risk/pCi)
1.62E-13
2.51E-12
2.12E-12
325E-13
7.68E-11
295E-10
316E-10
3.15E-10
520E-12
333E-10
300E-10
369E-13
3.13E-10
3.19E-10
326E-10
4.51 E-23
670E-22
2.12E-20
Inhalation
(Risk/pCi)
7.89E-14
5.76E-13
4.54E-13
1.00E-13
1.34E-08
2.74E-08
2.78E-08
2.78E-08
281E-10
3.88E-08
264E-08
2.67E-13
2.67E-08
2.67E-08
214E-09
5.93E-21
7.80E-20
2.77E-18
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
7.44E-09
3.15E-08
1.65E-07
232E-11
1.94E-11
1.26E-11
1.87E-11
OOOE+0
4.59E-09
1.55E-11
1 89E-08
1.29E-11
3.65E-06
3.30E-11
O.OOE+0
1.18E-10
3.23E-10
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
                                                                                                   11

-------
                    Table 4: Radionuclide Carcinogenicity -- Slope Factors'
                                      (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)



Potassium (19)

Praseodymium (59)



Promethium(61)



Protactinium (91)



Radium (88)
Isotope'
Po-215
Po-216
Po-218
K-40
K-42
Pr-142
Pr-143
Pr-144
Pr-144m
Pm-147
Pm-148
Pm-148m
Pm-149
Pa-231
Pa-233
Pa-234
Pa-234m
Ra-223
CASRNd
015706-52-2
015756-58-8
015422-24-9
013966-00-2
014378-21-3
014191-64-1
014981-79-4
014119-05-2
014119-05-2(m)
014380-75-7
014683-19-3
01 4683-1 9-3(m)
015765-31-8
014331-85-2
013981-14-1
015100-28-4
015100-28-4(m)
015623-45-7
Radioactive
Half-life*
1.78E-03
1.46E-01
3.05E+00
1.28E+09
1.24E+01
1.91E+01
1.36E+01
1.73E+01
7.20E+00
2.62E+00
5.37E+00
4.13E+01
5.31 E+01
3.73E+04
2.70E+01
6.70E+00
1.17E+00
1.14E+01
S
S
M
Y
H
H
D
M
M
Y
D
D
H
Y
D
H
M
D
ICRP
Lung
Class'
W
W
W
0
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
Gl
Absorption
Factor (f,)8
1.00E-01
1.00E-01
1.00E-01
9.50E-01
9.50E-01
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1.00E-03
1.00E-03
2.00E-01
Ingestion
(Risk/pCi)
499E-19
8 79E-17
5.08E-14
1.25E-11
1.29E-12
6 98E-12
6 60E-12
8.08E-14
3.23E-14
141E-12
1.44E-11
9.93E-12
5.52E-12
1.49E-10
469E-12
2.13E-12
4 77E-15
2.34E-10
Inhalation
(Risk/pCi)
4.48E-17
2.95E-15
369E-12
7.46E-12
7.56E-13
4.16E-12
5.60E-12
1.31E-13
5.61 E-14
7.49E-12
1.05E-11
2.95E-11
3.57E-12
2.42E-08
4.92E-12
1.30E-12
6.27E-15
3.60E-09
External Exposure
(Risk/yr per pCI/g soil)
511E-10
562E-11
O.OOE+0
6.11E-07
1.09E-06
2.34E-07
3.41E-14
1.33E-07
1 85E-09
6.35E-12
2.21 E-06
7.32E-06
3.65E-08
2 71E-08
4 54E-07
6.60E-06
4.05E-08
2.44E-07
(Table 4 continues on the following page: Refer to Endnotes on the last page.]
              12

-------
                   Table 4: Radionuclide Carcinogenicity -- Slope Factors8     MAY 1995
                                     (In Units of Picocuries5)
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0






Radon (86)


Rhodium (45)



Ra-224
Ra-225
Ra-226
Ra-226+D
Ra-228
Ra-228+D
Rn-219
Rn-220
Rn-222+D1
Rh-103m
Rh-105
Rh-105m
Rh-106
CASRN"
013233-32-4
013981-53-8
013982-63-3
013982-63-3(+D)
015262-20-1
01 5262-20-1 (+D)
014835-02-0
022481-48-7
014859-67-7(+D)
007440-16-6(m)
014913-89-4
014913-89-4(m)
014234-34-5
ICRP
Radioactive Lung
Half-life* Class'
3.62E+00
1.48E+01
1.60E+03
1.60E+03
5.75E+00
5.75E+00
3.96E+00
5.56E+01
3.82E+00
5.61 E+01
3.54E+01
4.50E+01
D
D
Y
Y
Y
Y
S
S
D
M
H
S
W
W
W
W
W
W
*
*
*
Y
Y
Y
Gl
Absorption
Factor (f,)°
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
—
--
—
5.00E-02
5.00E-02
5.00E-02
Ingestion
(Risk/pCi)
1 49E-10
1 57E-10
2.95E-10
2.96E-10
2.46E-10
2.48E-10
—
—
--
8.19E-15
1 93E-12
1 08E-15
Inhalation External Exposure
(Risk/pCI) (Risk/yr per pCi/g soil)
2.25E-09
2.38E-09
2.72E-09
2.75E-09
961E-10
9.94E-10
6.91E-14
1.92E-13
7.57E-12
1.28E-14
1.22E-12
9 25E-16
2.48E-08
1.71E-09
1.31E-08
6.74E-06
0 OOE+0
3 28E-06
1.72E-07
1.88E-09
—
5.85E-11
2 49E-07
2.27E-08
2.99E+01 S Y 5.00E-02 363E-15 4.62E-15 7.57E-07
1 To derive the inhalation slope factor for Rn-222+D, EPA's Office of Radiation and Indoor Air (OR1A) uses a slightly different risk model and set of
exposure assumptions, including an inhalation rate of 2.2E+04 L/day; 50% equilibrium for decay products; and a risk coefficient of 2.36E-4 cases per working
level month (WLM). A more detailed description of ORIA's radon risk assessment methodology is provided in the EPA CRAVE Summary Sheet, Inhaled Rn-
222 and its Short Half-Life Decay Products.
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
                                                                                                   13

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors8
                                      (In Units of Picocuriesb)
MAY 1995
Element
(Atomic Number)
Rubidium (37)




Ruthenium (44)




Samarium (62)


Scandium (21)


Selenium (34)
Silicon (14)
Isotope'
Rb-82
Rb-86
Rb-87
Rb-88
Rb-89
Ru-97
Ru-103
Ru-105
Ru-106
Ru-106+D
Sm-147
Sm-151
Sm-153
So46
Sc-47
Sc-48
Se-75
Si-31
CASRN"
014391-63-0
014932-53-7
013982-13-3
014928-36-0
014191-65-2
015758-35-7
013968-53-1
014331-95-4
013967-48-1
013967-48-1(4-0)
014392-33-7
015715-94-3
015766-00-4
013967-63-0
014391-96-9
014391-86-7
014265-71-5
014276-49-4
Radioactive
Half-life*
1.25E+00
1.87E+01
4.73e+10
1.78E+01
1.54E+01
2.90E+00
3.94E+01
4.44E+00
3.68E+02
3.68E+02
1.06e+11
9.00E+01
4.67E+01
8.38E+01
3.42E+00
4.37E+01
1.20E+02
1.57E+02
M
D
Y
M
M
O
D
H
0
O
Y
Y
H
D
D
H
D
M
ICRP
Lung
Class'
O
D
0
D
D
Y
Y
Y
Y
Y
W
W
W
Y
Y
Y
W
W
Gl
Absorption
Factor (f,)a
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
3.00E-04
3.00E-04
3.00E-04
1.00E-04
1.00E-04
1.00E-04
8.00E-01
1.00E-02
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.05E-14
7.12E-12
3.68E-12
1.46E-13
8.65E-14
588E-13
3.32E-12
1.15E-12
3.45E-11
3.45E-11
2.51E-11
4.60E-13
4.02E-12
5.73E-12
2 95E-12
665E-12
6.53E-12
5.04E-13
Inhalation
(Risk/pCi)
1.17E-14
4.21E-12
2.26E-12
1.36E-13
6.92E-14
4.09E-13
4.59E-12
8.02E-13
1.15E-10
1.15E-10
6.93E-09
4.63E-12
2.18E-12
1.31E-11
201E-12
4.20E-12
4.92E-12
3.29E-13
External Exposure
(Risk/yr per pCi/g soil)
3.89E-06
3.71 E-07
O.OOE+0
2.68E-06
8.47E-06
4.52E-07
1.70E-06
2.88E-06
O.OOE+0
7.57E-07
O.OOE+0
2.92E-13
4.65E-08
789E-06
2.50E-07
1.31E-05
889E-07
3.45E-09
Jabte 4 continues on the following page: Refer to Endnotes on the last page.]
             14

-------
                    Table 4: Radionuclide Carcinogenicity - Slope Factors3
                                     (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Silver (47)







Sodium (11)

Strontium (38)







Isotope0
Ag-105
Ag-108
Ag-108m
Ag-108m+D
Ag-109m
Ag-110
Ag-110m
Ag-111
Na-22
Na-24
Sr-82
Sr-85
Sr-85m
Sr-89
Sr-90
Sr-90+D
Sr-91
Sr-92
CASRN"
014928-14-4
014391-65-2
014391-65-2m
014391-65-2m(+D)
014378-38-2(m)
014391-76-5
014391-76-5(m)
157690-04-0
013966-32-0
013982-04-2
014809-50-8
013967-73-2
013967-73-2(m)
014158-27-1
010098-97-2
010098-97-2(+D)
014331-91-0
014928-29-1
Radioactive
Half-life*
4.13E+01
2.37E+00
1.27E+02
1.27E+02
3.96E+01
2.46E+01
2.50E+02
7.46E+00
2.60E+00
1.50E+01
2.50E+01
6.48E+01
6.77E+01
5.06E+01
2.86E+01
2.86E+01
9.50E+00
2.71E-KX)
D
M
Y
Y
S
S
D
D
Y
H
D
D
M
D
Y
Y
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
D
D
D
D
D
D
D
D
D
D
Gl
Absorption
Factor (f,)fl
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
9.50E-01
9.50E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
Ingestion
(Risk/pCi)
1.63E-12
6 94E-15
605E-12
6 05E-12
271E-16
244E-15
843E-12
6 83E-12
802E-12
1 38E-12
2 58E-1 1
1.40E-12
1.80E-14
1.03E-11
409E-11
5.59E-11
2 82E-12
2 03E-12
Inhalation
(Risk/pCi)
2.33E-12
9.43E-15
7.02E-11
7.02E-11
3.46E-16
3.16E-15
3.21 E-11
5.24E-12
4.88E-12
7.51E-13
8.87E-12
1.14E-12
7.13E-15
3.68E-12
5.94E-11
6.93E-1 1
7.79E-13
4.70E-13
External Exposure
(Risk/yr per pCi/g soil)
—
5.78E-08
561E-06
5.62E-06
1.16E-09
1.13E-07
1 05E-05
8.51 E-08
8.18E-06
1 .77E-05
9.00E-11
1.54E-06
5.24E-07
5.38E-10
O.OOE+0
O.OOE+0
2.67E-06
5.20E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
                                                                                                   15

-------
                     Table 4: Radionuclide Carcinogenicity - Slope Factors8
                                      (In Units of Picocuriesb)
MAY 1995
Element
(Atomic Number)
Sulfur (16)
Tantalum (73)
Technetium (43)







Tellurium (52)







Isotope6
S-35
Ta-182
Tc-95
Tc-95m
Tc-96
Tc-96m
Tc-97
Tc-97m
Tc-99
Tc-99m
Te-125m
Te-127
Te-127m
Te-129
Te-129m
Te-131
Te-131m
Te-132
CASRN"
015117-53-0
013982-00-8
014809-56-4
014809-56-4(m)
014808-44-7
014808-44-7(m)
015759-35-0
015759-35-0(m)
014133-76-7
014133-76-7(m)
014390-73-9(m)
013981-49-2
013981-49-2(m)
014269-71-7
014269-71-7(m)
014683-12-6
014683-12-6(m)
014234-28-7
Radioactive
Half-life*
8.74E+01
1.15E+02
2.00E+01
6.10E+01
4.28E+00
5.15E+01
2.60E+06
8.90E+01
2.13E+05
6.02E+00
5.80E+01
9.35E+00
1.09E+02
6.96E+01
3.36E+01
2.50E+01
3.00E+01
7.82E+01
D
D
H
D
D
M
Y
D
Y
H
D
H
D
M
D
M
H
H
ICRP
Lung
Class'
O
Y
W
W
W
W
W
W
W
W
W
W
W
W
W
W
W
W
61
Absorption
Factor (f,)fl
8.00E-01
1.00E-03
8.00E-01
8.00E-01
8 OOE-01
8.00E-01
8.00E-01
8.00E-01
8.00E-01
8.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
4 16E-13
703E-12
6.81E-14
1 24E-12
2.28E-12
261E-14
1.58E-13
1.20E-12
1 40E-12
5.58E-14
251E-12
8.55E-13
601E-12
1 48E-13
1.17E-11
3.90E-13
881E-12
1 22E-1 1
Inhalation
(Risk/pCi)
1.85E-13
1.65E-11
3.38E-14
2.10E-12
1.94E-12
2.26E-14
3.44E-13
1.96E-12
2.89E-12
3.49E-14
2.85E-12
4.32E-13
1.31E-11
1.46E-13
1.33E-11
2.48E-13
8.40E-12
8.38E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
466E-06
2 72E-06
2.08E-06
9.36E-06
7 72E-08
2.49E-10
2.67E-10
6.19E-13
2.51 E-07
2.16E-09
1.62E-08
7.10E-10
1.46E-07
6.92E-08
1.35E-06
5.31 E-06
4.31E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
                                                                                                   16

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                   Table 4: Radionuclide Carcinogenicity -- Slope Factors8
                                     (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Terbium (65)

Thallium (81)



Thorium (90)








Thulium (69)

Tin (50)
Isotope'
Tb-158
Tb-160
TI-202
TI-204
TI-208
TI-209
Th-227
Th-228
Th-228+D
Th-229
Th-229+D
Th-230
Th-231
Th-232
Th-234
Tm-170
Tm-171
Sn-113
CASRN"
015759-55-4
013981-29-8
015720-57-7
013968-51-9
014913-50-9
015690-73-0
015623-47-9
014274-82-9
014274-82-9(+D)
015594-54-4
015594-54-4(+D)
014269-63-7
014932-40-2
007440-29-1
015065-10-8
013981-30-1
014333-45-0
013966-06-8
Radioactive
Half-life*
1.50E+02
7.23E+01
1.22E+01
3.78E+00
3.05E+00
2.20E+00
1.87E+01
1.91E+00
1.91E+00
7.34E+03
7.34E+03
7.70E+04
2.55E+01
1.41E+10
2.41 E+01
1.29E+02
1.92E+00
1.15E+02
Y
D
D
Y
M
M
D
Y
Y
Y
Y
Y
H
Y
D
D
Y
D
ICRP
Lung
Class'
W
W
O
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)B
3.00E-04
3.00E-04
9.50E-01
9.50E-01
9.50E-01
9.50E-01
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
300E-04
3.00E-04
2.00E-02
Ingestion
(Risk/pCi)
420E-12
7.62E-12
1.01E-12
1 97E-12
1.75E-14
1 40E-14
4 04E-1 1
629E-11
2.31E-10
5.65E-11
3.56E-10
375E-11
1.79E-12
328E-11
1 93E-1 1
7 50E-12
586E-13
3.72E-12
Inhalation
(Risk/pCi)
7.04E-1 1
1.14E-11
6.07E-13
1.15E-12
1.36E-14
1.12E-14
4.31 E-09
9.45E-08
9.68E-08
7.60E-08
8.26E-08
1.72E-08
1.10E-12
1.93E-08
1.90E-11
1.10E-11
1.84E-12
6.61 E-1 2
External Exposure
(Risk/yr per pCi/g soil)
—
4.03E-06
1 .42E-06
8 72E-10
1.45E-05
7.83E-06
1.74E-07
5.28E-10
9.94E-07
5.94E-08
5.99E-07
4.40E-11
2.09E-09
1.97E-11
350E-09
3.84E-09
3.15E-10
2.96E-09
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
                                                                                                   17

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                    Table 4: Radionuclide Carcinogenicity - Slope Factors'
                                      (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)




Tungsten (74)


Uranium (92)









Vanadium (23)
Isotope0
Sn-121
Sn-121m
Sn-125
Sn-126
W-181
W-185
W-187
U-232
U-233
U-234
U-235
U-235+D
U-236
U-237
U-238
U-238+D
U-240
V-48
CASRN"
014683-06-8
014683-06-8(m)
014683-08-0
015832-50-5
015749-46-9
014932-41-3
014983-48-3
014158-29-3
013968-55-3
013966-29-5
015117-96-1
01 511 7-96-1 (+D)
013982-70-2
014269-75-1
007440-61-1
007440-61 -1(+D)
015687-53-3
014331-97-6
Radioactive
Half-life*
2.71E-KM
5.55E+01
9.64E+00
1.00E+05
1.21E+02
7.51 E+01
2.38E+01
7.20E+01
1.59E+05
2.45E+05
7.04E+08
7.04E+08
2.34E+07
6.75E+00
4.47E+09
4.47E+09
1.41E+01
1.60E+01
H
Y
O
Y
0
D
H
Y
Y
Y
Y
Y
Y
O
Y
Y
H
0
ICRP
Lung
Class'
W
W
W
W
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
Gl
Absorption
Factor (f,)"
200E-02
2.00E-02
2.00E-02
2.00E-02
3.00E-O1
300E-01
3.00E-01
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
500E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
1.00E-02
Ingestion
(Risk/pCi)
122E-12
200E-12
1.68E-11
2.12E-11
2.72E-13
2.04E-12
246E-12
8.12E-11
4.48E-11
444E-11
452E-11
4.70E-11
421E-11
398E-12
427E-11
6.20E-11
547E-12
756E-12
Inhalation
(Risk/pCi)
613E-13
7.46E-12
1.19E-11
4.26E-11
8.02E-14
4.26E-13
529E-13
5.29E-08
1.41E-08
140E-08
1.30E-08
1.30E-08
1.32E-08
3.12E-12
1.24E-08
124E-08
3.35E-12
6.84E-12
External Exposure
(Risk/yr per pCi/g soil)

—
1.21E-06
332E-08
2.11E-08
5.03E-11
1.63E-06
3.42E-11
3.52E-11
2.14E-11
2.63E-07
2.65E-07
1.72E-11
1.37E-07
1.50E-11
525E-08
1.09E-10
1.12E-05
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
             18

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                   Table 4: Radionuclide Carcinogenicity - Slope Factors8
                                    (In Units of Picocuriesb)
MAY 1995
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Xenon (54)











Yttrium (39)




Zinc (30)
Isotope6
Xe-122
Xe-123
Xe-125
Xe-127
Xe-129m
Xe-131m
Xe-133
Xe-133m
Xe-135
Xe-135m
Xe-137
Xe-138
Y-90
Y-91
Y-91m
Y-92
Y-93
Zn-65
CASRN"
015151-09-4
015700-10-4
013994-18-8
013994-19-9
013965-99-6(m)
01 4683-1 1-5(m)
014932-42-4
014932-42-4(m)
014995-62-1
014995-62-1 (m)
014835-21-3
015751-81-2
010098-91-6
014234-24-3
014234-24-3(m)
015751-59-4
014981-70-5
013982-39-3
ICRP Gl
Radioactive Lung Absorption Ingestion
Half-life" Class' Factor (f,)fl (Risk/pCi)
2.01 E+01
2.14E+00
1.68E+01
3.64E+01
8.89E+00
1.18E+01
5.25E+00
2.19E+00
9.11E+00
1.54E+01
3.83E+00
1.41E+01
6.41 E+01
5.85E+01
4.97E+01
3.54E+00
1.01E+01
2.44E+02
H -
U • „. —
LJ * 	
D —
D — -
D —
D —
D —
LJ * 	 	
M -
M —
M — —
H Y 1.00E-04 1.50E-11
D Y 1.00E-04 1.35E-11
M Y 1.00E-04 3.69E-14
H Y 1.00E-04 1 95E-12
H Y 1.00E-04 574E-12
D Y 5.00E-01 993E-12
Inhalation
(Risk/pCi)
3.08E-15
8.92E-16
1.20E-15
4.09E-16
5.74E-16
4.13E-16
4.14E-16
5.12E-16
7.45E-16
1.88E-16
1.39E-15
2.06E-15
9.90E-12
1.85E-11
2.99E-14
1.61E-12
3.48E-12
9.98E-12
External Exposure
(Risk/yr per pCI/g soil)
—
—
—
—
—
—
—
—
—
—
—
—
O.OOE+0
1.41E-08
1 90E-06
9.80E-07
3.41E-07
2.27E-06
[Table 4 continues on the fottowing page: Refer to Endnotes on the last page.]
                                                                                                   19

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                    Table 4: Radionuclide Carcinogenicity - Slope Factors8
                                     (In Units of Picocuriesb)
MAY 1995


Element
(Atomic Number)


Zirconium (40)




lsotopec
Zn-69
Zn-69m
Zr-93
Zr-95
Zr-97


CASRN"
013982-23-5
013982-23-5(m)
015751-77-6
013967-71-0
014928-30-4


Radioactive
Half-life*
5.56E+01
1.38E+01
1.53E+06
6.40E+01
1.69E-«-01



M
H
Y
D
H

ICRP
Lung
Class'
Y
Y
W
W
W
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Gl
Absorption
Factor (f,)8
5.00E-01
5.00E-01
2.00E-03
2.00E-03
2.00E-03

Ingestion
(Risk/pCi)
6.19E-14
1.52E-12
521E-13
3.92E-12
1.04E-11

Inhalation
(Risk/pCi)
1.04E-13
1.17E-12
5.26E-12
6.48E-12
4.73E-12

External Exposure
(Risk/yr per pCi/g soil)
2.03E-1 1
1.43E-06
O.OOE+0
2.81 E-06
6.85E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
             20

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                              Table  4:  Radionuclide Carcinogenicity -- Slope  Factors3      MAY 1995
                                                        (In Units of Picocuriesb)
ENDNOTES:
    EPA classifies all radionuclides as Group A (known human) carcinogens. Radionuclide slope factors are calculated by EPA's Office of Radiation and Indoor Air (ORIA)
to assist HEAST users with risk-related evaluations and decision-making at various stages of the remediation process.  Ingestion and inhalation slope factors are central
estimates in a linear model of the age-averaged, lifetime attributable radiation cancer incidence (fatal and nonfatal cancer) risk per unit of activity inhaled or ingested, expressed
as risk/picocurie (pCi). External exposure slope factors are central estimates of the lifetime attributable radiation cancer incidence risk for each year of exposure to external
radiation from photon-emitting radionuclides distributed uniformly in a thick layer of soil, and are expressed as risk/yr per pCi/gram of soil. If required, slope factors in Table
4 can be converted into the International System (SI) units of becquerels (1 Bq = 1 nuclear transformation per second) by dividing each inhalation, ingestion, or external
exposure value by 27.03. Users can calculate cancer risks using slope factors expressed in either customary units or SI units with equivalent results, provided that they also
use air, water and soil concentration values in the same system of units.  For a discussion on the derivation of radionuclide slope factors and guidance on their use, refer to
the User's Guide section on radionuclide carcinogenicity.

    A curie (Ci), the customary unit of activity, is equal to 3.7 x 1010 nuclear transformations per second. 1 picocurie (pCi) = 1012 Ci.

    For each radionuclide listed, slope factors correspond to the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that
the risks from associated short-lived radioactive decay products (i.e., those decay products with radioactive half-lives less than or equal to 6 months) are also included. Refer
to Exhibit 1 in the User's Guide section on radionuclide carcinogenicity for guidance on determining slope factors for partial or complete radioactive decay chains.

    Chemical Abstract Service Reference Number (CASRN). For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each
chain member.

    Radioactive half-life: S - Second, M = Minute, D = Day, Y = Year. For those radionuclides with decay products (+D), half-lives are listed for the parent radionuclide.

    Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.

g   Gastrointestinal (Gl) absorption factors are the fractional amounts of each radionuclide absorbed across the Gl tract into the bloodstream. Lung clearance classifications
and Gl absorption factors are provided for reference only.  DggQt use these factors to adjust inhalation or ingestion slope factors. See the User's Guide for instructions.
                                                                                                                                                   21

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               APPENDIX A: TECHNICAL INFORMATION

I.    DATA SOURCES AND SELECTION CRITERIA USED IN HEAST

II.    DOSE CONVERSIONS ON HEAST

III.    CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY
     NUMBER CROSS REFERENCE

IV.    EFFECT LEVEL DEFINITIONS

V.    NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)

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                               APPENDIX A-l

        I.  DATA SOURCES AND SELECTION CRITERIA USED IN HEAST


A. Description of Sources and Documents Cited in HEAST

      1. The Integrated Risk Information System (IRIS)

      IRIS is an on-line data base developed by the EPA for compilation of risk
assessment and regulatory information on chemicals and physical agents. IRIS is the
primary communications mechanism for distribution of health hazard assessment
information derived by the various intra-Agency Work Groups.  The primary intent of
IRIS is to provide guidance to EPA personnel in making risk management decisions.
An IRIS chemical file contains a Work Group verified summary of the available
information on hazard and dose-response assessment for noncarcinogenic and/or
carcinogenic effects for that chemical and is not an extensive toxicologic data base.
Risk assessment values placed on IRIS are considered Agency consensus and take
precedence over differing risk assessment values  from other EPA sources. Each file
includes referenced citations and EPA contacts for obtaining further information on any
specific chemical or agent. The IRIS data base was made available to State and local
governments, as well as to the public, in April 1988.

* Questions concerning IRIS:  Call RISK INFORMATION HOTLINE at (513) 569-7254


      2. EPA Work Groups:

   Risk assessment values for chemicals currently being considered by EPA Work
Groups, but not yet on IRIS, are included  in HEAST. The EPA Reference
Dose/Reference Concentration (RfD/RfC) Work Group and the Carcinogen Risk
Assessment Verification Endeavor (CRAVE) Work Group validates Agency systemic
toxicity and carcinogen risk assessments, respectively.  These Work Groups are also
responsible for resolving any conflicts regarding toxicity values developed by various
Program Offices. Work Group members represent many different EPA offices and are
scientists experienced in issues related to both the qualitative and quantitative risk
assessment of carcinogenic and toxic agents. Values verified by these Work Groups
have undergone extensive peer review and represent an Agency consensus.  Verified
risk assessment values are entered into the IRIS data base monthly.

* Questions concerning RfD/RfC Work Group:  Call Annie Jarabek NCEA-Research
Triangle Park (RTP) at (919) 541-4847
                                    A-1

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* Questions concerning CRAVE Work Group: Call Jim Cogliano at (202) 260-3814
NCEA-Washington, DC
      3. Office of Research and Development (ORD/National Center for
      Environmental Assessment (NCEA) OSWER-OAQPS (Office of Solid Waste and
      Emergency Response-Office of Air Quality Planning and Standards) Documents:

   A listing of most ORD/NCEA OSWER-OAQPS documents can be found in the
Chemical Assessments and Related Activities (CARA) list (available through  NTIS) or in
the CERI (Center for Environmental Research Information) Office of Research and
Development publications list.  The CARA is produced by the National Center for
Environmental Assessment (NCEA). All OSWER-OAQPS documents are subject to a
minimum of internal EPA peer review or a maximum of EPA/Peer Review
Workshop/Science Advisory Board and public comments prior to finalization.

* Information on the availability of OSWER-OAQPS documents can be obtained from
the following sources:

      All Documents:

      Technical Information Staff
      National Center for Environmental Assessment (RD-689)
      U.S. Environmental Protection Agency
      401 M Street, S.W.
      Washington, D.C.  20460
      (202) 260-7345

      Published Documents:

      Technology Transfer and Support Division, National Risk Management
           Research Laboratoryt
      Office of Research and  Development
      U.S. Environmental Protection Agency
      26 W. Martin Luther King Drive
      Cincinnati, OH 45268
      (513)569-7562
      fFormerly, Center for Environmental Research Information (CERI)

      Documents Available Through RCRA/Superfund:

      Hotline Number 1-800-424-9346
                                   A-2

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      Documents Available from NTIS:

      National Technical Information Service (NTIS)
      5285 Port Royal Road
      Springfield, VA 22161
      (703) 487-4650

Health Effects Assessments (HEAs):  This document series was prepared by the
National Center for Environmental Assessment (NCEA-CIN) for the Office of
Emergency and Remedial Response (Superfund). HEAs are intended for use by the
OERR in evaluating risk for its preliminary assessment process at uncontrolled sites,
and for appraising clean-up alternatives in its remedial investigation/feasibility studies.
HEAs are brief, quantitatively oriented, preliminary assessment of relevant health
effects data. HEAs are subject to internal EPA review by staff within the Office of Health
and Environmental Assessment.  Final drafts of HEAs become part of the RCRA and
Superfund dockets and are available through NTIS.  This series has recently been
incorporated into the following HEED series.

Health and Environmental Effects Documents (HEEDs):  This document series is
prepared by the National Center for Environmental Assessment (NCEA-CIN) for the
Office of Solid Waste and Emergency Response (OSWER). HEEDs are intended to
support listings under the Resource Conservation and Recovery Act (RCRA) as well as
to provide health-related limits and goals for emergency and remedial actions under the
Comprehensive Environmental Response, Compensation and Liability Act (CERCLA).
Within a HEED,  both published literature and information within Agency Program
Offices are evaluated as they pertain to potential human  health, aquatic life and
environmental effects of hazardous waste constituents.  Quantitative estimates,
including reference doses for chronic and subchronic duration for both inhalation and
oral exposures, carcinogenic potency factors, unit risk estimates for air and drinking
water, and reportable quantities (RQs) based on chronic  toxicity and carcinogenicity are
determined when sufficient data are available. HEEDs are  subject to internal EPA
review by staff within the Office of Health and Environmental Assessment and the
Office of Pesticides and Toxic Substances. Final drafts of HEEDs become part of the
RCRA and Superfund public dockets and are available through NTIS.

Health and Environmental Effects Profiles (HEEPs):  This document series was
prepared by the  National Center for Environmental Assessment (NCEA-CIN) for the
Office of Solid Waste and Emergency Response (OSWER). HEEPs have been
superseded by HEEDs since mid-FY87.  HEEPs are intended to support listings of
hazardous constituents of a wide range of waste streams under Section 3001  of the
Resource Conservation and Recovery Act (RCRA), as well  as to provide health-related
limits for emergency actions under Section 010 of the Comprehensive Environmental
Response, Compensation and Liability Act (CERCLA). HEEPs are summaries of the

                                    A-3

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literature concerning health hazards associated with environmental exposures to
chemicals or compounds and are very similar to HEEDs as described above. HEEPs
were subject to internal EPA review by staff within the Office of Health and
Environmental Assessment. HEEPS are part of the RCRA and CERCLA public
dockets.  Final drafts are available through NTIS.

Air Quality Criteria Documents (AQCDs): This document series is prepared by the
National Center for Environmental Assessment (NCEA-RTP) for the Office of Air and
Radiation (OAR). AQCDs are intended to support National Ambient Air Quality
Standards (NAAQS) set under Sections  108-110 of the Clean Air Act.  These
documents are evaluations of the available scientific literature on the potential health
effects of air pollutants.  AQCDs are subject to internal EPA review by staff within  the
Office of Health and Environmental Assessment and the Office of Air and Radiation.
Further review is conducted by the Science Advisory Board/Clean Air Scientific
Advisory Committee, and then, these documents are subject to peer review workshops
and public comments. The AQCDs are mandated by the Clean Air Act and are revised
at 5-year intervals. AQCDs become part of the OAR public docket and final drafts are
available through NTIS.

Health Assessment Documents (HADs): This document series is prepared by the
National Center for Environmental Assessment (NCEA-RTP and NCEA-CIN) for the
Office of Air and Radiation (OAR). HADs are intended for use by the Office of Air
Quality Planning and Standards (OAQPS) to determine possible listing of hazardous air
pollutants (HAP) under sections 111 and 112 of the Clean Air Act. These documents
are evaluations of the available scientific literature on the potential health effects of air
pollutants and serve as the scientific data base for establishing relationships between
exposure concentrations and potential health risks. HADs are subject to internal EPA
review by staff within the Office of Health and Environmental Assessment and the
Office of Air and Radiation. Further review is conducted by the Science Advisory
Board/Clean Air Scientific Advisory Committee, and then, these documents are subject
to peer review workshops and public comments. HADs become part of the OAR public
docket and final drafts are available through NTIS.

   4.  Miscellaneous Documents:

Drinking Water Criteria Documents (DWCDs): The National Center for Environmental
Assessment (NCEA-CIN) prepares a portion of this document series for the Office of
Water (OW). DWCDs are intended to assist the OW in deriving criteria standards  for
chemicals in drinking water, as required under Section 412(b)(3)(A) of the Safe Drinking
Water Act, as amended in 1986. The DWCDs are comprehensive evaluations of
potential health effects, including mechanisms of toxicity, with specific emphasis on
data providing dose-response information.  DWCDs contain Health Advisories (Has) for
1-day, 10-day and longer-term exposures and drinking water equivalent levels for

                                     A-4

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lifetime exposures. DWCDs are subject to internal EPA review by staff within the Office
of Health and Environmental Assessment and the Office of Water. Selected documents
are reviewed by the Science Advisory Board and are subject to peer review workshops
and public comments. DWCDs become part of the Safe Drinking Water (SOW) public
docket and final drafts are available through NTIS.
B. Selection Criteria and Sources of HEAST Values

   Chemicals with derived noncarcinogenic and/or carcinogen risk assessment values
that have had some level of peer review (i.e., those in peer reviewed EPA documents
or under review by EPA Work Groups) are included in HEAST; this does not include
many interim values (values not found in final EPA documents or not being considered
by Work Groups) derived for various purposes within Superfund and other Program
Offices.  In updating the HEAST, the first source that is checked is the Integrated Risk
Information System (IRIS) for revised or newly added risk assessment values.
Secondly, the status of chemicals under discussion by the RfD/RfC and CRAVE Work
Groups is reviewed. The National Center for Environmental Assessment's Chemical
Assessments and Related Activities (CARA) list is also reviewed for new Office of
Water, Office of Air Quality Planning and Standards, and Office of Solid Waste and
Emergency Response risk assessment documents (HEEDs, HEEPs, HEAs, HADs,
AQCDs, DWCDs).

   The HEAST also contains chemicals commonly found at RCRA (Resource
Conservation and Recovery Act) sites as identified by the Office of Solid Waste's
Technical Assessment Branch.  Questions about RCRA chemicals may be addressed
by calling the Health Assessment Section (Office of Solid Waste) at (202) 260-4761.
Finally, the Office of Radiation Programs provides data on radionuclides for Table 4A
and 4B of the HEAST. Radionuclides included are those thought to be most commonly
encountered at Superfund sites.  Questions concerning radionuclides carcinogenicity
should first be addressed by contacting the appropriate Regional Radiation Program
Manager. A listing of these managers and several contacts in the Office of Radiation
Programs can be found in  Exhibit 2 of the User's Guide -Radionuclide Carcinogenicity.
                                    A-5

-------
                                APPENDIX A-ll

                      II.  DOSE CONVERSIONS ON HEAST

      In January 1991, the decision was made to replace inhalation Reference Doses
(RfDi) for noncancer toxicity and inhalation slope factors for carcinogenicity, previously
available on the IRIS data base, with Reference Concentrations (RFC) and inhalation
unit risks, respectively.  RfCs and unit risks are expressed in terms of concentration in
air (mg/m3), not in terms of "dose" (mg/kg-day) like the RfDs and the oral and inhalation
slope factors. This presents a problem for the Superfund program, since the current
Hazard Ranking System (MRS) and the Risk Assessment Guidance for superfund
(RAGS): Human  Health Evaluation manual, Parts A and B were developed using
chronic daily intakes and health criteria expressed in units of mg/kg-day.

      The decision to replace inhalation slope factors and RfDi values expressed in
mg/kg-day with unit risk and RfC values expressed in mg/m3 was based  on two major
factors: 1) the workgroups felt that it was technically more accurate to base toxicity
values directly on measured air concentrations instead of making the metabolic
pharmacokinetic and/or surface area adjustments required to estimate an "internal
dose"; and 2) there are compounds that elicit route-of-entry effects (e.g., sensitizers
and irritants) where the toxic effect is to the respiratory system or exchange boundary
where a measure of "internal dose" might inappropriately imply effects to other organ
systems or effects from  other exposure routes.

      Superfund recognizes the importance of these issues and is actively working
with EPA's Office of Research and  Development to evaluate the impact of these
changes on its program regulations and guidance.  In the short term, however,
modification of program regulations and guidance is not a viable option.  Therefore, the
chairs of the RfD/RfC and CRAVE Work Groups were consulted regarding Superfund's
need to make the conversion from a concentration in air to dose. There was agreement
that, in many cases, converting the air concentration data to a dose (in mg/kg-day) may
not add significant uncertainty to the Superfund risk assessment process, and therefore
may be a reasonable use of the data given appropriate circumstances and Superfund
program objectives. These Work Groups will continue to work with the Superfund
program to identify specific instances where it is not appropriate to make the conversion
from unit risk/RfC to inhalation slope factor/RfD due to the large uncertainty introduced
by the assumptions used in the conversion.

      Generally, the Superfund Health Risk Technical Support Center will be
responsible for making all appropriate conversions and the values will be identified with
appropriate highlights or footnotes in the Health Effects Assessment Summary Tables
(HEAST). Therefore, HEAST users are strongly advised against making such
conversions themselves. However, it is a critical responsibility of the risk assessor to

                                      A-7

-------
consult the original reports cited in the HEAST and to appropriately characterize or
caveat the resulting risk estimates derived from these values so that managers are fully
informed of their origin and related uncertainties.
                                       A-8

-------
                            APPENDIX A-lll

         III. CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE
                REGISTRY NUMBER CROSS REFERENCE

     This section lists chemicals and their respective Chemical Abstracts Service
Registry Number (CASRN) for cross referencing on the HEAST. Chemicals may be
searched either alphabetically by chemical name or numerically by the CASRN.
                                 A-9

-------
                               CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
                                                                  (LISTED  BY NAME)
                                                                                          Nay  1995
ACENAPHTHENE                        000083-32-9
ACENAPTHYLENE                       000208-96-8
ACEPHATE                            030560-19-1
ACETONE                             000067-64-1
ACETONE CYANOHYDRIH                 000075-86-5
ACETONITR1LE                        000075-05-8
ACETOPHEMONE                        000098-86-2
ACROLEIN                            000107-02-8
ACRYLAMIDE                          000079-06-1
ACRYLIC ACID                        000079-10-7
ACRYLOMITRILE                       000107-13-1
ADIPOMITRILE                        000111-69-3
ALACHLOR                            015972-60-8
ALDICARB                            000116-06-3
ALDRIN                              000309-00-2
ACLIDOCHLOR                         000093-71-0
ALLYL ALCOHOL                       000107-18-6
ALLYL CHLORIDE                      000107-05-1
ALUMINUM                            007429-90-5
ALUMINUM  PHOSPHIDE                  020859-73-8
AMETRYN                             000834-12-8
AMINO-2-NAPHTHOL.  1-                002834-92-6
AMINO-2-NAPHTOL HYDROCHLORIDE.  1-   001198-27-2
AMINOPHENOL, M-                     000591-27-5
AMINOPHENOL, 0-  •                   000095-55-6
AMINOPHENOL, P-                     000123-30-8
AMINOPYRIDINE.  4-                    000504-24-5
AMMONIA                             007664-41-7
ANILINE                             000062-53-3
ANTHRACENE                          000120-12-7
ANTIMONY. METALLIC                  007440-36-0
ANTIMONY  PENTOXIDE                  001314-60-9
ANTIMONY  POTASSIUM TARTRATE         000304-61-0
ANTIMONY  TETROXIDE                  001332-81-6
 ANTIMONY  TR10XIDE                   001309-64-4
 ARAMITE                             000140-57-8
 AROCLOR 1248                        012672-29-6
 AROCLOR 1254                        011097-69-1
 ARSENIC.  INORGANIC                  007440-38-2
 ASBESTOS                            001332-21-4
 ATRAZINE                            001912-24-9
 AZOBENZENE                          000103-33-3
 BARIUM                              007440-39-3
 BARIUM CYANIDE                      000542-62-1
 BENEFIN                             001861-40-1
 BENZAL CHLORIDE                     000098-87-3
 BENZALDEHYDE                        000100-52-7
 BENZALDEHYDE CYANOHYDRIN            000532-28-5
BENZENE                             000071-43-2
BENZENETHIOL / (THIOPHENOL)         000108-98-5
BENZIDINE                           000092-87-5
BENZOIC ACID                        000065-85-0
BENZOTRICHLORIDE                    000098-07-7
BENZOtA] ANTHRACENE                  000056-55-3
BENZOCA1PYRENE                      000050-32-8
BENZOW1FLUORANTHENE                000205-99-2
BENZOK1FLUORANTHENE                000207-08-9
BENZYL ALCOHOL                      000100-51-6
BENZYL CHLORIDE                     000100-44-7
BERYLLIUM                           007440-41-7
BIPHENYL. 1.V                      000092-52-4
BIS(2-CHLOROETHYL) ETHER            000111-44-4
BIS(2-CHLOROISOPROPYL) ETHER        039638-32-9
BIS(2-CHLORO-1-METHYLETHYL) ETHER   000108-06-1
BIS(2-ETHYLHEXYL) PHTHALATE
BIS(CHLOROMETHYL) ETHER
BISPHENOL A
BORON, ELEMENTAL
BORON TRIFLUORIDE
BROMIMATED DIBENZO-P-DIOXINS
BROMINATED DIBENZOFURANS
BROMOACETONE
BROMOCHLOROETHANES
BROMODICHLOROMETHANE
BROMOETHENE /  (VINYL  BROMIDE)
BROMOFORM
BROMOHETHANE
BROMOPHENYL PHENYL  ETHER,  4-
BROMOPHOS
BROMOXYNIL
BROMOXYNIL OCTANOATE
BUSAN  77
 BUSAN  90
 BUTADIENE,  1.3-
 BUTANOL. 1-
 BUTYL  BENZYL  PHTHALATE.  N-
 BUTYLATE
 BUTYLCHLORIDE, T-
 BUTYROLACTONE. GAMMA-
 CACODYLIC ACID
 CADMIUM
 CALCIUM CYANIDE
 CAPROLACTAM
 CAPTAFOL
 CAPTAN
 CARBARYL
(DEHP)000117-81-7
      000542-88-1
      000080-05-7
      007440-42-8
      007637-07-2
         NO CASRN
         NO CASRN
      000598-31-2
         NO CASRN
      000075-27-4
      000593-60-2
      000075-25-2
      000074-83-9
      000101-55-3
      002104-96-3
      001689-84-5
      001689-99-2
      031512-74-0
      002491-38-5
      000106-99-0
      000071-36-3
      000085-68-7
      002008-41-5
      000507-20-0
      000096-48-0
      000075-60-5
      007440-43-9
      000592-01-8
      000105-60-2
      002425-06-1
      000133-06-2
      000063-25-2
                     CARBAZOLE
                     CARBOFURAN
                     CARBON DISULFIDE
                     CARBON MONOXIDE
                     CARBON TETRACHLORIDE
                     CHLORAL
                     CHLORANIL
                     CHLORDANE
                     CHLORINE CYANIDE
                     CHLORO-1.3-BUTADIENE.
                                    000086-
                                    001563-
                                    000075-
                                    000630-
                                    000056-
                                    000075
                                    000118
                                    000057
                                    000506
                      2- / (CHLOROPRENE)
                                    000126
CHLORO-2-METHYLANILINE, 4-          000095
CHLORO-2-METHYLANILINE HYDROCHLORIDE, 4-
                                    003165
CHLORO-M-CRESOL, P-
CHLOROACETALDEHYDE
CHLOROACETIC ACID
CHLOROANILINE, 2-
CHLOROANILINE, 3-
CHLOROANILINE, 4-
CHLOROBENZENE
CHLOROBENZILATE
CHLOROBENZOIC ACID, P-
CHLOROBENZOTRIFLUORIDE, 4-
CHLOROBUTANE, 1-
CHLOROBUTANE, 2-
CHLOROCYCLOPENTADIENE
CHLOROFORM
CHLOROMETHANE /  (METHYL CHLORIDE)
CHLOROHETHYL METHYL ETHER
CHLORONITROBENZENE, M-
                    0-
                    P-
                                          74-8
                                          66-2
                                          15-0
                                          05-0
                                          23-5
                                          87-6
                                          75-2
                                          •74-9
                                          •77-4

                                          -99-8
                                          -69-2
CHLORONITROBENZENE,
CHLORONITROBENZENE,
CHLOROPHENOL, 2-
CHLOROPHENOL, 3-
CHLOROPHENOL, 4-
CHLOROPRENE
CHLOROPROPANE, 2-
CHLOROTHALONIL
CHLOROTOLUENE, M-
CHLOROTOLUENE, 0-
CHLOROTOLUENE, P-
CHLORPYRIFOS
CHLORPYRIFOS METHYL
CHLORTHIOPHOS
CHROMIUM(111)
CHROMIUM(VI)
CHRYSENE
000059
000107
000079
000095
000108
000106
000108
000510-
000074-
000098-
000109-
000078-
041851-
000067-
000074-
000107-
000121
000088
000100
000095
000108
000106
000126
000075
001897
000108
000095
000106
002921
005598
060238
016065
018540
000218
93-3
50-7
20-0
11-8
51-2
42-9
47-8
90-7
•15-6
•11-3
•56-6
•69-3
•86-4
-50-7
-66-3
-87-3
-30-2
-73-3
-73-3
-00-5
-57-8
 43-0
 48-9
 99-8
 29-6
 45-6
•41-8
•49-8
•43-4
•88-2
•13-0
-56-4
-83-1
-29-9
-01-9
                                                                                                                                           NAME/CASRN-1

-------
                               CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
                                                             (LISTED BY NAME)  continued
                                                                                                                                              Nay 1995
 COKE OVEN EMISSIONS
 COPPER
 COPPER  CYANIDE
 CREOSOTE.  COAL TAR
 CRESOL, N- / (3-NETHYLPHENOL)
 CRESOL, 0- / (2-HETHYLPHENOU
 CRESOL, P- / (4-METHYLPHENOL)
 CROTONALDEHYDE
 CUMENE
 CYANAZINE
 CYANIDE
 CYANOGEN
 CYANOGEN  BROMIDE
 CYCLOATE
 CYCLOHEXANOL
 CYCLOHEXYLAMINE
 CYCLONITE
 CYCLOPENTADIENE
 DACTHAL
 DALAPON
 2,4-DB
 DDD
 DDE
 DDT
 DECABROMODIPHENYL  ETHER
 DEHP
 DI-N-OCTYL PHTHALATE
 DIALLATE
 DIAZINON
 DIBENZOFURAN
 DIBENZO[A,H]ANTHRACENE
 DIBROMO-3-CHLOROPROPANE,  1.2
 DIBROMOBENZENE, 1,4-
 DIBROMOCHLOROMETHANE
 DIBROMOETHANE,  1.2-
 DIBUTYL PHTHALATE
 DICAMBA
 DICHLORO-2-BUTENE.  1.4-
 DICHLOROBENZENE, 1.2-
 DICHLOROBEN2ENE, 1,3-
 DICHLOROBENZENE, 1.4-
DICHLOROBENZIDINE, 3.3'-
DICHLOROBUTENES
DICHLORODIFLUOROMETHANE
DICHLOROETHANE, 1,1-
DICHLOROETHMIE. 1.2-
DICHLOROETHYLENE. 1,1-
DICHLOROETHYLENE, 1.2- (NIXED
      008007-45-2
      007440-50-8
      000544-92-3
      008001-58-9
      000108-39-4
      000095-48-7
      000106-44-5
      000123-73-9
      000098-82-8
      021725-46-2
      000057-12-5
      000460-19-5
      000506-68-3
      001134-23-2
      000108-93-0
      000108-91-8
      000121-82-4
      000542-92-7
      001861-32-1
      000075-99-0
      000094-82-6
      000072-54-8
      000072-55-9
      000050-29-3
      001163-19-5
      000117-81-7
      000117-84-0
      002303-16-4
      000333-41-5
      000132-64-9
      000053-70-3
      000096-12-8
      000106-37-6
      000124-48-1
      000106-93-4
      000084-74-2
      001918-00-9
      000764-41-0
      000095-50-1
      000541-73-1
      000106-46-7
      000091-94-1
         NOCASRN
      000075-71-8
      000075-34-3
      000107-06-2
      000075-35-4
ISONERS)
DICHLOROETHYLENE,  1,2-C-
DICHLOROETHYLENE.  1,2-T-
DICHLOROMETHANE
DICHLOROPHENOL, 2,3-
DICHLOROPHENOL, 2,4-
DICHLOROPHENOL, 2,5-
DICHLOROPHENOL, 2,6-
DICHLOROPHENOL. 3,4-
DICHLOROPHENOL, 3.5-
DICHLOROPHENOXY ACETIC ACID, 2.4-
DICHLOROPHENOXY) BUTYRIC ACID, 4-(2
    (2.4-DB)
DICHLOROPROPANE, 1,1-
DICHLOROPROPANE, 1,2-
DICHLOROPROPANE, 1.3-
DICHLOROPROPANE, 2.2-
DICHLOROPROPENE, 1,3- / (TELONE II)
DICHLORPROP
DICYCLOPENTADIENE
DIELDRIN
DIETHYL-P-NITROPHENYL PHOSPHATE
DIETHYL PHTHALATE
DIETHYLAMI LINE, N.N-
DIETHYLENE GLYCOL MONOBUTYL ETHER
DIETHYLENE GLYCOL MONOETHYL ETHER
DIETHYLFORMAMIDE
DIETHYLHYDRAZINE, 1.2-
DIETHYLSTILBESTROL
DIMETHOATE
DIMETHOXYBENZIDINE, 3,3'-
DINETHYLANILINE, 2,4-
DIMETHYLANILINE HYDROCHLORIDE, 2.4-
DINETHYLANILINE, N.N-
DIMETHYLBENZIDINE. 3,3'-
DIMETHYLBENZ[A]ANTHRACENE, 7.12-
DINETHYLFORMAMIDE, N,N-
DIMETHYLHYDRAZINE, 1,1-
DIMETHYLHYDRAZINE. 1,2-
DIMETHYLPHENOL. 2,3-
DIMETHYLPHENOL, 2,4-
DIMETHYLPHENOL, 2,5-
DIMETHYLPHENOL, 2,6-
DIMETHYLPHENOL. 3,4-
DIMETHYLPHTHALATE
DIMETHYLSULFATE
DIMETHYLTEREPHTHALATE
DIMETHYLUREA,  N.N-
 000540-59-0    DINITRO-0-CRESOL, 4,6-
 000156-59-2    DINITRO-P-CRESOL, 2,6-
 000156-60-5    DINITROBENZENE.  1.2-
 000075-09-2    DINITROBENZENE.  1.3-
 000576-24-9    DINITROBENZENE,  1,4-
 000120-83-2    DINITROPHENOL, 2,3-
 000583-78-8    DINITROPHENOL, 2,4-
 000087-65-0    DINITROPHENOL, 2,5-
 000095-77-2    DINITROPHENOL, 2,6-
 000591-35-5    DINITROPHENOL, 3,5-
 000094-75-7    DINITROTOLUENE,  2,3-
,4-  /            DINITROTOLUENE,  2,4
 000094-82-6    DINITROTOLUENE,  2,5-
 000078-99-9    DINITROTOLUENE,  2,6-
 000078-87-5    DINITROTOLUENE.  3,4-
 000142-28-9    DINOSEB
 000594-20-7    DIOXANE,  1,4-
 000542-75-6    DIPHENYLAMINE, N,N-
 000120-36-5    DIPHENYLHYDRAZINE, 1,2-
 000077-73-6    DIPHENYLMETHANE  DIISOCYANATE
 000060-57-1    DIRECT BLACK 38
 000311-45-5    DIRECT BLUE 6
 000084-66-2    DIRECT BROUN 95
 000091-66-7    DIRECT LIGHTFAST BLUE
 000112-34-5    DIRECT SKY BLUE  6B
 000111-90-0    DISULFOTON
 000617-84-5    ENDOSULFAN
 001615-80-1    ENDOTHALL
 000056-53-1    ENDRIN
 000060-51-5    EPICHLOROHYDRIN
 000119-90-4    EPTC
 000095-68-1    ETHOPROP
 021436-96-4    ETHOXYETHANOL, 2-
 000121-69-7    ETHOXYETHANOL ACETATE, 2-
 000119-93-7    ETHOXYETHANOL ACRYLATE. 2-
 000057-97-6    ETHOXYETHANOL DODECANOATE,  2-
 000068-12-2    ETHOXYETHANOL PHOSPHATE, 2-
 000057-14-7    ETHOXYETHYL METHACRYLATE,  2-
 000540-73-8    ETHYL ACETATE
 000526-75-0    ETHYL ACRYLATE
 000105-67-9    ETHYL BENZENE
 000095-87-4    ETHYL CHLORIDE
 000576-26-1    ETHYL ETHER
 000095-65-8    ETHYL METHACRYLATE
 000131-11-3    ETHYL-0-XYLENE,  4-
 000077-78-1    ETHYLANILINE. N-
 000120-61-6    ETHYLENE  CYANOHYDRIN
 000598-94-7    ETHYLENE  DIAMINE
000534
000609
000528
000099-
000100
000066
000051
000329
000573
000586
000602
000121
000619
000606
000610
000088
000123-
000122-
000122-
000101
001937
002602
016071
004399-
002610
000298
000115-
000145-
000072
000106-
000759-
013194-
000110-
000111-
000106
000106
068554
002370
000141-
000140-
000100-
000075-
000060-
000097
000934-
000103-
000109-
000107-
52-1
93-8
29-0
65-0
25-4
56-8
28-5
71-5
56-8
11-8
01-7
14-2
15-8
20-2
39-9
85-7
91-1
39-4
66-7
68-8
37-7
46-2
86-6
55-7
05-1
04-4
29-7
73-3
20-8
89-8
94-4
48-4
80-5
15-9
74-1
13-8
00-7
63-0
78-6
88-5
41-4
00-3
29-7
63-2
80-5
69-5
78-4
15-3
                                                                                                                                          NAME/CASRN-2

-------
                               CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
                                                            (LISTED BY NAME)  Continued
                                                                                          May 1995
ETHYLENE GLYCOL                     000107-21-1
ETHYLEHE GLYCOL NONOBUTYL ETHER     000111-76-2
ETHYLENE OXIDE                      000075-21-8
ETHYLEME THIOUREA                   000096-45-7
ETHYLTOLUENE. M-                    000620-14-4
ETHYLTOLUENE, 0-                    000611-14-3
ETHYLTOLUENE, P-                    000622-96-8
FLUORANTHENE                        000206-44-0
FLUORENE                            000086-73-7
FLUORINE / (SOLUBLE FLUORIDE)       007782-41-4
FLURIDONE                           059756-60-4
FOLPET                              000133-07-3
FORMALDEHYDE                        000050-00-0
FORMALDEHYDE CYANOHYDRIN            000107-16-4
FORMIC ACID                         000064-18-6
FURAN                               000110-00-9
FURAZOLIDONE                        000067-45-8
FURFURAL                            000098-01-1
FURIUM                              000531-82-8
GLYCIDALDEHYDE                      000765-34-4
HEPTACHLOR                          000076-44-8
HEPTACHLOR EPOXIDE                  001024-57-3
HEPTANE, N-                         000142-82-5
HEXABROMOBENZENE                    000087-82-1
HEXACHLOROBENZENE                   000118-74-1
HEXACHLOROBUTADIENE                 000087-68-3
HEXACHLOROCYCLOHEXANE, ALPHA-       000319-84-6
HEXACHLOROCYCLOHEXANE, BETA-        000319-85-7
HEXACHLOROCYCLOHEXANE. DELTA-       000319-86-8
HEXACHLOROCYCLOHEXANE, EPSILON-     006108-10-7
HEXACHLOROCYCLOHEXANE, GAMMA-       000058-89-9
HEXACHLOROCYCLOHEXANE-TECHNICAL     000608-73-1
HEXACHLOROCYCLOPENTADIENE           000077-47-4
HEXACHLOROETHANE                    000067-72-1
HEXACHLOROPHENE                     000070-30-4
HEXAMETHYLENE DIAMINE               000124-09-4
HEXANE, N-                          000110-54-3
HEXANONE, 2-                        000591-78-6
HYDRAZINE                           000302-01-2
HYDRAZINE SULFATE                   010034-93-2
HYDROGEN SULFIDE                    007783-06-4
HYDROQUINONE                        000123-31-9
INDENOI1,2,3-CD]PYRENE              000193-39-5
IRON                                007439-89-6
ISOBUTYL ALCOHOL                    000078-83-1
ISOPHORONE                          000078-59-1
ISOPROPALIN                         033820-53-0
LACTONITRILE                        000078-97-7
LEAD                                007439-92-1
LEAD ALKYLS                            NO CASRN
LINURON                             000330-55-2
MALATHION                           000121-75-5
MALEIC ANHYDRIDE                    000108-31-6
MALEIC HYDRAZIDE                    000123-33-1
MALONONITRILE                       000109-77-3
MANCOZEB                            008018-01-7
MANEB                               012427-38-2
MANGANESE                           007439-96-5
MEPHOSFOLAN                         000950-10-7
MERCURIC CHLORIDE                   007487-94-7
MERCURY, ELEMENTAL                  007439-97-6
MERPHOS                             000150-50-5
MERPHOS OXIDE                       000078-48-8
METHACRYLONITRILE                   000126-98-7
METHANOL                            000067-56-1
METHOMYL                            016752-77-5
METHOXY-5-NITROANILINE, 2-          000099-59-2
METHOXYCHLOR                        000072-43-5
METHOXYETHANOL, 2-                  000109-86-4
METHOXYETHANOL ACETATE, 2-          000110-49-6
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2-
                                    000094-81-5
METHYL-4-CHLOROPHENOXY) PROPIONIC ACID, 2-(2-
                                    000093-65-2
METHYL-4-CHLOROPHENOXY ACETIC ACID, 2-
                                    000094-74-6
METHYL-5-NITROANILINE, 2-           000099-55-8
METHYL ACETATE                      000079-20-9
METHYL ACRYLATE                     000096-33-3
METHYL CHLORIDE                     000074-87-3
METHYL CHLOROCARBONATE              000079-22-1
METHYL ETHYL KETONE                 000078-93-3
METHYL ETHYL KETONE PEROXIDE        001338-23-4
METHYL HYDRAZINE                    000060-34-4
METHYL ISOBUTYL KETONE              000108-10-1
METHYL ISOCYANATE                   000624-83-9
METHYL MERCURY                      022967-92-6
METHYL METHACRYLATE                 000080-62-6
METHYL PARATHION                    000298-00-0
METHYL STYRENE  (MIXED  ISOMERS)      025013-15-4
METHYL STYRENE, ALPHA               000098-83-9
METHYLAN I LINE,  2-                   000095-53-4
METHYLANILINE HYDROCHLORIDE, 2-     000636-21-5
METHYLCHOLANTHRACENE, 3-            000056-49-5
METHYLCYCLOHEXANE                   000108-87-2
METHYLENE-BIS(2-CHLOROANILINE), 4,4'-
                                    000101-14-4
HETHYLENE-BIS(N,N'-DIMETHYL)ANILINE, 4,4'-
                                    000101-61-1
METHYLENE BROMIDE                   000074-95-3
METHYLENE CHLORIDE / (DICHLOROMETHANE)
                                    000075-09-2
METHYLENE-BIS(BENZENEAMINE), 4,4- /
    (METHYLENE DIANILINE, 4,4-)     000101-77-9
METHYLENEDIPHENYL ISOCYANATE, 4,4- /
     (DIPHENYLMETHANE DIISOCYANATE) 000101-68-8
2-METHYLLACTONITRILE
2-METHYLPHENOL
3-METHYLPHENOL
4-METHYLPHENOL
METOLACHLOR
METRIBUZIN
MI REX
MOLINATE
MOLYBDENUM
MONOCHLORAMINE
NAPHTHALENE
NAPHTHOQUINONE, 1,4-
NIAGARA BLUE 4B
NICKEL CYANIDE
NICKEL, REFINERY DUST
NICKEL, SOLUBLE SALTS
NICKEL SUBSULFIDE
NICOTINONITRILE
NITRIC OXIDE
NITRITE
NITROANILINE, 2-
NITROANILINE, M-
NITROANILINE, P-
NITROBENZENE
NITROFURANTOIN
NITROFURAZONE
NITROGEN DIOXIDE
NITROGEN OXIDES
NITROMETHANE
NITROPHENOLS
NITROPROPANE, 2-
NITROSO-DI-N-BUTYLAMINE,  N-
NITROSO-DI-N-PROPYLAMINE,  N-
NITROSO-N-ETHYLUREA, N-
NITROSO-N-METHYLUREA,  N-
NITROSODIETHANOLAMINE. N-
NITROSODIETHYLAMINE, N-
NITROSODIMETHYLAMINE,  N-
000075-86-5
000095-48-7
000108-39-4
000106-44-5
051218-45-2
021087-64-9
002385-85-5
002212-67-1
007439-98-7
010599-90-3
000091-20-3
000130-15-4
002429-74-5
000557-19-7
    NO CASRN
     Various
012035-72-2
000100-54-9
010102-43-9
014797-65-0
000088-74-4
000099-09-2
000100-01-6
000098-95-3
000067-20-9
000059-87-0
010102-44-0
    NO CASRN
000075-52-5
    NO CASRN
000079-46-9
000924-16-3
000621-64-7
000759-73-9
000684-93-5
001116-54-7
000055-18-5
 000062-75-9

NAME/CASRN-3

-------
                               CHEMICAL NAME AND CHEMICAL  ABSTRACTS SERVICE  REGISTRY NUMBER CROSS REFERENCE
                                                             (LISTED BY NAME)  continued
 NITROSODIPHENYLAMINE,  P-
 NITROSODIPHENYLAMINE,  N-
 NITROSOMETHYLETHYLANINE, N-
 NITROSOHETHYLVINYLAMINE, N
 NITROSOPYRROLIDIME,  N-
 NITROTOLUENE,  M-
 NITROTOLUENE,  0-
 NITROTOLUEME,  P-
 OCTABROMOOIPHENYL ETHER
 OCTAMETHYLPYROPHOSPHORAMIDE
 OSMIUM TETROXIOE
 OZONE
 PARALDEHYDE
 PARATHION
 PART ICULATE  MATTER
 PEBULATE
 PENDIMETHALIN
 PENTABROMO-6-CHLOROCYCLOHEXANE.

 PENTABROMODIPHENYL ETHER
 PENTACHLOROBENZENE
 PENTACHLOROCYCLOPENTAOIENE
 PENTACHLOROMITROBENZENE
 PENTACHLOROPHENOL
 PENTACHLOROPROPENE,  1.1,2.3,3,-
 PENTANE, N-
 PHENANTHRENE
 PHENOL
 PHENYLENEDIAMINE.  M-
 PHEMYLENEDIAMINE,  0-
 PHENYLENEDIAMINE,  P-
 PHENYLMERCURIC ACETATE
 PHENYLPHENOL. 2-
 PHORATE
 PHOSGENE
 PHOSPHINE
 PHOSPHORUS,  WHITE
 PHOTOCHEMICAL OXIDANTS
 PHTHALIC ACID, H-
 PHTHALIC ACID, 0-
 PHTHALIC ACID, P-
 PHTHALIC ANHYDRIDE
 POLYBROMINATED BIPHENYLS
POLYCHLORINATED BIPHENYLS
POTASSIUM CYANIDE
POTASSIUM SILVER CYANIDE
PROFLURALIN
PRONAMIDE
    000156-10-5    PROPACHLOR                          001918-16-7
    000086-30-6    PROPAZINE                           000139-40-2
    010595-95-6    PROPIONITRILE                       000107-12-0
    004549-40-0    PROPYL ALCOHOL, N-                  000071-23-8
    000930-55-2    PROPYLENE GLYCOL                    000057-55-6
    000099-08-1    PROPYLENE GLYCOL MONOETHYL ETHER
    000088-72-2                                        001569-02-4
    000099-99-0    PROPYLENE GLYCOL MONOMETHYL ETHER
    032536-52-0                                        000107-98-2
    000152-16-9    PROPYLENE OXIDE                     000075-56-9
    020816-12-0    PYRENE                              000129-00-0
    010028-15-6    PYRIDINE                            000110-86-1
    000123-63-7    QUINCLINE                           000091-22-5
    000056-38-2    RDX / (CYCLONITE)                   000121-82-4
       NO CASRN    RONNEL                              000299-84-3
    001114-71-2    SELENIOUS ACID                      007783-00-8
    040487-42-1    SELENIUM                            007782-49-2
1,2,3,4,5-          SELENIUM SULFIDE                    007446-34-6
    000087-84-3    SELENOUREA                          000630-10-4
    032534-81-9    SILVER                              007440-22-4
    000608-93-5    SILVER CYANIDE                      000506-64-9
    025329-35-5    SIMAZINE                            000122-34-9
    000082-68-8    SODIUM CYANIDE                      000143-33-9
    000087-86-5    SODIUM DIETHYLDITHIOCARBAMATE       000148-18-5
    001600-37-9    SODIUM METAVANADATE                 013718-26-8
    000109-66-0    STIROPHOS                           000961-11-5
    000085-01-8    STRONTIUM, STABLE                   007440-24-6
    000108-95-2    STRYCHNINE                          000057-24-9
    000108-45-2    STYRENE                             000100-42-5
    000095-54-5    SUCCINONITR1LE                      000110-61-2
    000106-50-3    SULFUR DIOXIDE                      007446-09-5
    000062-38-4    SULFUR OXIDES                          NO CASRN
    000090-43-7    SULFURIC ACID                       007664-93-9
    000298-02-2    TCDD.  2.3.7.8-                      001746-01-6
    000075-44-5    TELONE II                           000542-75-6
    007803-51-2    TEMEPHOS                            003383-96-8
    007723-14-0    TERBUFOS                            013071-79-9
       NO CASRN    TEREPHTHALIC ACID                   000100-21-0
    000121-91-5    TETRACHLOROAZOXYBENZENE              021232-47-3
    000088-99-3    TETRACHLOROBENZENE,  1,2,4,5-         000095-94-3
    000100-21-0    TETRACHLOROCYCLOPENTADIENE           000695-77-2
    000085-44-9    TETRACHLOROETHANE,  1.1,1,2-          000630-20-6
       NO CASRN    TETRACHLOROETHANE,  1,1,2,2-          000079-34-5
    001336-36-3    TETRACHLOROETHYLENE                  000127-18-4
    000151-50-8    TETRACHLOROHYDRAZOBENZENE            071753-42-9
    000506-61-6    TETRACHLOROPHENOL, 2,3,4,5-          004901-51-3
    026399-36-0    TETRACHLOROPHENOL, 2,3.4,6-          000058-90-2
    023950-58-5    TETRACHLOROPHENOL, 2,3,5,6-          000935-95-5
 TETRACHLOROPROPENE,  1,1,2,3-
 TETRACHLOROTOLUENE.  PARA, ALPHA.

 TETRACHLOROVINPHOS / (STIROPHOS)
 TETRAETHYL DITHIOPYROPHOSPHATE
 THALLIC OXIDE
 THALLIUM  (I) ACETATE
 THALLIUM  (I) CARBONATE
 THALLIUM  (I) CHLORIDE
 THALLIUM,  INSOLUBLE  SALTS
      May 1995

   010436-39-2
ALPHA, ALPHA-
   005216-25-1
   000961-11-5
   003689-24-5
   001314-32-5
   000563-68-8
   006533-73-9
   007791-12-0
      NO CASRN
 THALLIUM  (I) NITRATE
 THALLIUM  SELENITE
 THALLIUM  (I) SULFATE
 THIOCYANOMETHYLTHIO)BENZOTHIAZOLE,

 THIOFANOX
 THIOPHENOL
 THIRAM
 TIN AND COMPOUNDS
 TOLUENE
 TOLUENE-2.4-DIAMINE
 TOLUENE-2,5-DIAHINE
 TOLUENE-2.6-DIAMINE
 TOLUENEDIAMINE, 2,3-
 TOLUENEDIAMINE, 3,4-
 TOLUIDINE, M-
 TOLUIDINE, P-
 TOXAPHENE
 TRIALLATE
 TRIBROMOBENZENE. 1,2,4-
 TRICHLORO-1,2,2-TRIFLUOROETHANE, 1,

 TRICHLORO-2'-HYDROXYDIPHENYLETHER,

 TRICHLOROANILINE, 2,4,6-
 TRICHLOROANILINE HYDROCHLORIDE, 2,4

 TRICHLOROBENZENE, 1,2,4-
 TRICHLOROCYCLOPENTADIENE
 TRICHLOROETHANE, 1,1,1-
 TRICHLOROETHANE, 1,1,2-
 TRICHLOROETHYLENE
TRICHLOROFLUOROMETHANE
 TRICHLOROPHENOL, 2,3,4-
 TRICHLOROPHENOL, 2,3,5-
TRICHLOROPHENOL, 2,3,6-
TRICHLOROPHENOL, 2.4.5-
   010102-45-1
   012039-52-0
   007446-18-6
  2-(
   021564-17-0
   013196-18-4
   000108-98-5
   000137-26-8
      NO CASRN
   000108-88-3
   000095-80-7
   000095-70-5
   000823-40-5
   002687-25-4
   000496-72-0
   000108-44-1
   000106-49-0
   008001-35-2
   002303-17-5
   000615-54-3
  1,2-
   000076-13-1
  2 2 4'-
   003380-34-5
   000634-93-5
  ,6-
   033663-50-2
   000120-82-1
   077323-84-3
   000071-55-6
   000079-00-5
   000079-01-6
   000075-69-4
   015950-66-0
   000933-78-8
   000933-75-5
   000095-95-4
                                                                                                                                          NAME/CASRN-4

-------
                              CHEMICAL  NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER  CROSS REFERENCE
                                                           (LISTED BY NAME)   continued
Nay 1995
TRICHLOROPHENOL,  2,4,6-             000088-06-2
TRICHLOROPHENOL,  3.4,5-             000609-19-8
TRICHLOROPHENOXY) PROPION1C ACID,  2(2,4,5-
                                    000093-72-1
TRICHLOROPHENOXY ACETIC ACID, 2,4,5-
                                    000093-76-5
TRICHLOROPROPAME, 1.1.1-            007789-89-1
TRICHLOROPROPANE. 1,1,2-            000598-77-6
TRICHLOROPROPAME, 1,2,2-            003175-23-3
TRICHLOROPROPANE, 1,2,3-            000096-18-4
TRICHLOROPROPENE, 1,2,3-            000096-19-5
TRICHLOROTOLUENE, 2,3,6-            002077-46-5
TRICHLOROTOLUENE, ALPHA,2,6-        002014-83-7
TRIFLURALIN                         001582-09-8
TRIMETHYL PHOSPHATE                 000512-56-1
TRINETHYLBENZENES                      NO CASRN
TRINITROBENZENE, 1,3,5-             000099-35-4
TRINITROPHENOLS                        NO CASRN
TRINITROPHENYLMETHYLNITRAMINE       000479-45-8
TRINITROTOLUENE, 2,4,6-             000118-96-7
URANIUM, SOLUBLE SALTS                 NO CASRN
VANADIUM                            007440-62-2
VANADIUM PENTOXIDE                  001314-62-1
VANADIUM SULFATE                    036907-42-3
VERNAM / (VERNOLATE)                001929-77-7
VERNOLATE                           001929-77-7
VINYL-1-CYCLOHEXENE. 4-             000100-40-3
VINYL ACETATE                       000108-05-4
VINYL BROMIDE                       000593-60-2
VINYL CHLORIDE                      000075-01-4
WARFARIN                            000081-81-2
XYLENE, M-                          000108-38-3
XYLENE, MIXTURE                     001330-20-7
XYLENE, 0-                          000095-47-6
XYLENE, P-                          000106-42-3
ZINC (METALLIC)                     007440-66-6
ZINC CYANIDE                        000557-21-1
ZINC PHOSPHIDE                      001314-84-7
ZIMEB                               012122-67-7
                                                                                                                                          NAME/CASRN-5

-------
                               CHEMICAL ABSTRACTS SERVICE REGISTRY  NUMBER AND CHEMICAL NAME  CROSS  REFERENCE
                                            (LISTED BY CHEMICAL  ABSTRACTS SERVICE  REGISTRY NUMBER)
000050-00-0                         FORMALDEHYDE    000074-11-3
000050-29-3                                 DDT    000074-83-9
000050-32-8                      BENZODUPYRENE    000074-87-3
000051-28-5                 DINITROPHENOL, 2,4-    000074-87-3
000053-70-3              DIBENZO[A,H]ANTHRACENE    000074-95-3
000055-18-5              NITROSODIETHYLAMINE, N-    000075-00-3
000056-23-5                CARBON TETRACHLORIDE    000075-01-4
000056-38-2                           PARATHION    000075-05-8
000056-49-5             METHYLCHOLANTHRACENE. 3-    000075-09-2
000056-53-1                  DIETHYLSTILBESTROL    000075-09-2
000056-55-3                  BENZO [A]ANTHRACENE    000075-15-0
000057-12-5                             CYANIDE    000075-21-8
000057-14-7              DIMETHYLHYDRAZINE, 1,1-    000075-25-2
000057-24-9                          STRYCHNINE    000075-27-4
000057-55-6                    PROPYLENE GLYCOL    000075-29-6
000057-74-9                           CHLORDANE    000075-34-3
000057-97-6    DIMETHYLBENZ[A]ANTHRACENE, 7,12-    000075-35-4
000058-89-9        HEXACHLOROCYCLOHEXANE, GAMMA-    000075-44-5
000058-90-2          TETRACHLOROPHENOL, 2,3,4,6-    000075-52-5
000059-50-7                 CHLORO-M-CRESOL, P-    000075-56-9
000059-87-0                       NITROFURAZONE    000075-60-5
000060-29-7                         ETHYL ETHER    000075-69-4
000060-34-4                    METHYL HYDRAZINE    000075-71-8
000060-51-5                          DIHETHOATE    000075-86-5
000060-57-1                            DIELDRIN    000075-86-5
000062-38-4              PHENYLMERCURIC ACETATE    000075-87-6
000062-53-3                             ANILINE    000075-99-0
000062-75-9             NITROSODIMETHYLAMINE, N-    000076-13-1
000063-25-2                            CARBARYL            TRICHLORO-
000064-18-6                         FORMIC ACID    000076-44-8
000065-85-0                        BENZOIC ACID    000077-47-4
000066-56-8                 DINITROPHENOL, 2,3-    000077-73-6
000067-20-9                      NITROFURANTOIN    000077-78-1
000067-45-8                        FURAZOLIDONE    000078-48-8
000067-56-1                            METHANOL    000078-59-1
000067-64-1                             ACETONE    000078-83-1
000067-66-3                          CHLOROFORM    000078-86-4
000067-72-1                    HEXACHLOROETHANE    000078-87-5
000068-12-2              DIMETHYLFORMAMIDE, N,N-    000078-93-3
000070-30-4                     HEXACHLOROPHENE    000078-97-7
000071-23-8                  PROPYL ALCOHOL, N-    000078-99-9
000071-36-3                         BUTANOL, 1-    000079-00-5
000071-43-2                             BENZENE    000079-01-6
000071-55-6              TRICHLOROETHANE, 1,1,1-    000079-06-1
000072-20-8                              ENDRIN    000079-10-7
000072-43-5                        METHOXYCHLOR    000079-11-8
000072-54-8                                 ODD    000079-20-9
000072-55-9                                 DDE    000079-22-1
       CHLOROBENZOIC ACID.  P-
                 BRONOMETHANE
              METHYL CHLORIDE
                CHLOROMETHANE
            METHYLENE BROMIDE
               ETHYL CHLORIDE
               VINYL CHLORIDE
                 ACETONITRILE
           METHYLENE CHLORIDE
              DICHLOROMETHANE
             CARBON DISULFIDE
               ETHYLENE OXIDE
                    BROMOFORM
         BROMODICHLOROMETHANE
            CHLOROPROPANE,  2-
         DICHLOROETHANE, 1,1-
       DICHLOROETHYLENE, 1,1-
                     PHOSGENE
                 NITROMETHANE
              PROPYLENE OXIDE
               CACODYLIC ACID
       TRICHLOROFLUOROMETHANE
      DICHLORODIFLUOROMETHANE
         2-METHYLLACTONITRILE
          ACETONE CYANOHYDRIN
                      CHLORAL
                      DALAPON

1,2,2-TRIFLUOROETHANE, 1,1,2-
                   HEPTACHLOR
    HEXACHLOROCYCLOPENTADIENE
            DICYCLOPENTADIENE
              DIMETHYLSULFATE
                MERPHOS OXIDE
                   ISOPHORONE
             ISOBUTYL ALCOHOL
             CHLOROBUTANE,  2-
        DICHLOROPROPANE, 1,2-
          METHYL ETHYL KETONE
                 LACTONITRILE
        DICHLOROPROPANE, 1,1-
      TRICHLOROETHANE, 1,1,2-
            TRICHLOROETHYLENE
                   ACRYLAMIDE
                 ACRYLIC ACID
            CHLOROACETIC ACID
               METHYL ACETATE
       METHYL CHLOROCARBONATE
000079-34-5
000079-46-9
000080-05-7
000080-62-6
000081-81-2
000082-68-8
000083-32-9
000084-66-2
000084-74-2
000085-01-8
000085-44-9
000085-68-7
000086-30-6
000086-73-7
000086-74-8
000087-65-0
000087-68-3
000087-82-1
                   May 1995

TETRACHLOROETHANE, 1,1,2,2-
           NITROPROPANE, 2-
                BISPHENOL A
        METHYL METHACRYLATE
                   WARFARIN
    PENTACHLORONITROBENZENE
               ACENAPHTHENE
          DIETHYL PHTHALATE
          DIBUTYL PHTHALATE
               PHENANTHRENE
         PHTHALIC ANHYDRIDE
 BUTYL BENZYL PHTHALATE. N-
   NITROSODIPHENYLAMINE, N-
                   FLUORENE
                  CARBAZOLE
       DICHLOROPHENOL, 2,6-
        HEXACHLOROBUTADIENE
           HEXABROHOBENZENE
000087-84-3
     PENTABROMO-6-CHLOROCYCLOHEXANE. 1.2,3,4,5-
000087-86-5
000088-06-2
000088-72-2
000088-73-3
000088-74-4
000088-85-7
000088-99-3
000090-43-7
000091-20-3
000091-22-5
000091-66-7
000091-94-1
000092-52-4
000092-87-5
          PENTACHLOROPHENOL
    TRICHLOROPHENOL, 2,4,6-
           NITROTOLUENE, 0-
     CHLORONITROBENZENE, 0-
           NITROANILINE, 2-
                    DINOSEB
          PHTHALIC ACID, 0-
           PHENYLPHENOL. 2-
                NAPHTHALENE
                  QUINCLINE
       DIETHYLANILINE, N,N-
   DICHLOROBENZIDINE, 3,3'-
             BIPHENYL, 1,1'
                  BENZIDINE
000093-65-2
  METHYL-4-CHLOROPHENOXY) PROPION1C ACID, 2-<2-
000093-71-0                         ALLIDOCHLOR
000093-72-1
     TR1CHLOROPHENOXY) PROPION1C ACID, 2(2,4,5-
000093-76-5
           TRICHLOROPHENOXY ACETIC ACID, 2,4,5-
000094-74-6
         METHYL-4-CHLOROPHENOXY ACETIC ACID, 2-
000094-75-7   DICHLOROPHENOXY ACETIC ACID, 2,4-
000094-81-5
    METHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2-
000094-82-6                              2,4-DB
000094-82-6
                                                                                                                                          CASRN/NAME-1

-------
                               CHEMICAL ABSTRACTS  SERVICE  REGISTRY NUMBER AND CHEMICAL  NAME CROSS REFERENCE
                                           (LISTED BY CHEMICAL ABSTRACTS REGISTRY  NUMBER)  continued
                                                                                          Hay 1995
        OICHLOROPHENOXY) BUTYRIC ACID, 4-(2,4-
000095-47-6                          XYLENE, 0-
000095-48-7                          CRESOL, 0-
000095-48-7                      2-METHYLPHENOL
000095-49-8                   CHLOROTOLUENE, 0-
000095-50-1               OICHLOROBENZENE, 1,2-
000095-51-2                   CHLOROANILINE, 2-
000095-53-4                   METHYLANIL1NE, 2-
000095-54-5                PHENYLENEDIAMINE. 0-
000095-55-6                     AMINOPHENOL, 0-
000095-57-8                    CHLOROPHENOL, 2-
000095-65-8                OIMETHYLPHENOL, 3.4-
000095-68-1               DIMETHYLANILINE, 2.4-
000095-69-2          CHLORO-2-HETHYLANILINE, 4-
000095-70-5                 TOLUENE-2.5-DIAMINE
000095-77-2                DICHLOROPHENOL, 3,4-
000095-80-7                 TOLUENE-2.4-DIAMINE
000095-87-4                DIHETHYLPHENOL, 2,5-
000095-94-3        TETRACHLOROBENZENE, 1,2,4,5-
000095-95-4             TRICHLOROPHENOL, 2,4,5-
000096-12-8        OIBROMO-3-CHLOROPROPANE, 1,2
000096-18-4            TRICHLOROPROPANE, 1,2,3-
000096-19-5            TRICHLOROPROPENE, 1,2,3-
000096-33-3                     METHYL ACRYLATE
000096-45-7                   ETHYLENE THIOUREA
000096-48-0               BUTYROLACTONE, GAMMA-
000097-63-2                  ETHYL METHACRYLATE
000098-01-1                            FURFURAL
000098-07-7                    BENZOTRICHLORIDE
000098-56-6          CHLOROBENZOTRIFLUORIDE, 4-
000098-82-8                              CUMENE
000098-83-9               METHYL STYRENE, ALPHA
000098-86-2                        ACETOPHENONE
000098-87-3                     BENZAL CHLORIDE
000098-95-3                        NITROBENZENE
000099-08-1                    NITROTOLUENE, M-
000099-09-2                    NITROANILINE. M-
000099-35-4             TRINITROBENZENE, 1.3,5-
000099-55-8           METHYL-5-NITROANILINE, 2-
000099-59-2          METHOXY-5-NITROANILINE, 2-
000099-65-0                DINITROBENZENE, 1.3-
000099-99-0                    NITROTOLUENE, P-
000100-00-5              CHLORONITROBENZENE, P-
000100-01-6                    NITROANILINE, P-
000100-21-0                   PHTHALIC ACID, P-
000100-21-0                   TEREPHTHALIC ACID
000100-25-4                DINITROBENZENE, 1,4-
000100-40-3             VINYL-1-CYCLOHEXENE, 4-
000100-41-4                       ETHYL BENZENE
000100-42-5                             STYRENE
000100-44-7                     BENZYL CHLORIDE
000100-51-6                      BENZYL ALCOHOL
000100-52-7                        BENZALDEHYDE
000100-54-9                     NICOT1NONITRILE
000101-14-4
          METHYLENE-BIS(2-CHLOROANIL1NE), 4,4'-
000101-55-3        BROMOPHENYL PHENYL ETHER, 4-
000101-61-1
     METHYLENE-BIS(N,N'-DIMETHYL)ANILINE, 4,4'-
000101-68-8        DIPHENYLMETHANE DIISOCYANATE
000101-68-8
            METHYLENEDIPHENYL ISOCYANATE, 4,4-
000101-77-9   METHYLENE-BIS(BENZENEAMINE), 4.4-
000103-33-3                          AZOBENZENE
000103-69-5                    ETHYLANILINE, N-
000105-60-2                         CAPROLACTAM
000105-67-9                DIMETHYLPHENOL, 2,4-
000106-13-8       ETHOXYETHANOL DODECANOATE, 2-
000106-37-6                DIBROMOBENZENE, 1,4-
000106-42-3                          XYLENE, P-
000106-43-4                   CHLOROTOLUENE, P-
000106-44-5                      4-METHYLPHENOL
000106-44-5                          CRESOL, P-
000106-46-7               DICHLOROBENZENE, 1,4-
000106-47-8                   CHLOROANILINE, 4-
000106-48-9                    CHLOROPHENOL, 4-
000106-49-0                       TOLUIDINE, P-
000106-50-3                PHENYLENEDIAMINE, P-
000106-74-1          ETHOXYETHANOL ACRYLATE, 2-
000106-89-8                     EPICHLOROHYORIN
000106-93-4                 DIBROMOETHANE, 1,2-
000106-99-0                     BUTADIENE, 1,3-
000107-02-8                            ACROLEIN
000107-05-1                      ALLYL CHLORIDE
000107-06-2                DICHLOROETHANE, 1,2-
000107-12-0                       PROPIONITRILE
000107-13-1                       ACRYLONITRILE
000107-15-3                    ETHYLENE DIAMINE
000107-16-4            FORMALDEHYDE CYANOHYDRIN
000107-18-6                       ALLYL ALCOHOL
000107-20-0                  CHLOROACETALDEHYDE
000107-21-1                     ETHYLENE GLYCOL
000107-30-2           CHLOROMETHYL METHYL ETHER
000107-98-2   PROPYLENE GLYCOL MONOMETHYL ETHER
000108-05-4                       VINYL ACETATE
000108-10-1              METHYL ISOBUTYL KETONE
000108-31-6                    MALE 1C ANHYDRIDE
000108-38-3                          XYLENE, M-
000108-39-4                      3-METHYLPHENOL
000108-39-4                          CRESOL. M-
000108-41-8                   CHLOROTOLUENE. M-
000108-42-9                   CHLOROANILINE, 3-
000108-43-0                    CHLOROPHENOL, 3-
000108-44-1                       TOLUIDINE, M-
000108-45-2                PHENYLENEDIAMINE, H-
000108-87-2                   METHYLCYCLOHEXANE
000108-88-3                             TOLUENE
000108-90-7                       CHLOROBENZENE
000108-91-8                     CYCLOHEXYLAMINE
000108-93-0                        CYCLOHEXANOL
                                                                                                                                          CASRN/NAME-2

-------
                              CHEMICAL ABSTRACTS SERVICE  REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
                                          (LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER)   continued
000108-95-2                              PHENOL    000123-33-1
000108-98-5                          THIOPHENOL    000123-63-7
000108-98-5                        BENZENETHIOL    000123-73-9
000108-06-1   BIS(2-CHLORO-1-METHYLETHYL) ETHER    000123-91-1
000109-66-0                         PENTANE, N-    000124-09-4
000109-69-3                    CHLOROBUTANE, 1-    000124-48-1
000109-77-3                       MALONONITRILE    000126-98-7
000109-78-4                ETHYLENE CYANOHYDRIN    000126-99-8
000109-86-4                  METHOXYETHANOL, 2-    000126-99-8
000110-00-9                               FURAN    000127-18-4
000110-49-6          METHOXYETHANOL ACETATE, 2-    000129-00-0
000110-54-3                          HEXANE, N-    000130-15-4
000110-61-2                      SUCC1NONITR1LE    000131-11-3
000110-80-5                   ETHOXYETHAMOL, 2-    000132-64-9
000110-86-1                            PYR1D1ME    000133-06-2
000111-15-9           ETHOXYETHANOL ACETATE, 2-    000133-07-3
000111-44-4            BIS(2-CHLOROETHYL) ETHER    000137-26-8
000111-69-3                        ADIPONITRILE    000139-40-2
000111-76-2     ETHYLENE GLYCOL NONOBUTYL ETHER    000140-57-8
000111-90-0   DIETHYLENE GLYCOL HONOETHYL ETHER    000140-88-5
000112-34-5   OIETHYLENE GLYCOL NONOBUTYL ETHER    000141-78-6
000115-29-7                          ENOOSULFAN    000142-28-9
000116-06-3                            ALDICARB    000142-82-5
000117-81-7         BIS(2-ETHYLHEXYL) PHTHALATE    000143-33-9
000117-81-7                                DEHP    000145-73-3
000117-84-0                DI-N-OCTYL PHTHALATE    000148-18-5
000118-74-1                   HEXACHLOROBENZENE    000150-50-5
000118-75-2                           CHLORANIL    000151-50-8
000118-96-7             TRINITROTOLUENE, 2,4,6-    000152-16-9
000119-90-4           DIMETHOXYBENZIDIME, 3,3'-    000156-10-5
000119-93-7            DIHETHYLBENZIDINE, 3,3'-    000156-59-2
000120-12-7                          ANTHRACENE    000156-60-5
000120-36-5                         DICHLORPROP    000193-39-5
000120-61-6                DIMETHYLTEREPHTHALATE    000205-99-2
000120-82-1            TRICHLOROBENZENE, 1,2,4-    000206-44-0
000120-83-2                DICHLOROPHENOL,  2,4-    000207-08-9
000121-14-2                  OINITROTOLUENE, 2,4    000208-96-8
000121-69-7                DINETHYLANILINE,  N,N-    000218-01-9
000121-73-3              CHLORONITROBENZENE, M-    000298-00-0
000121-75-5                           HALATHION    000298-02-2
000121-82-4                           CYCLONITE    000298-04-4
000121-82-4                                 RDX    000299-84-3
000121-91-5                   PHTHALIC ACID, H-    000302-01-2
000122-34-9                            SIHAZINE    000304-61-0
000122-39-4                  D1PHENYLAMINE,  N.N-    000309-00-2
000122-66-7             DIPHENYLHYORAZINE,  1,2-    000311-45-5
000123-30-8                     AMINOPHENOL, P-    000319-84-6
000123-31-9                         HYOROQUINONE    000319-85-7
              MALE 1C HYDRAZIDE    000319-86-8
                   PARALOEHYDE    000329-71-5
                CROTONALOEHYDE    000330-55-2
                 DIOXANE, 1.4-    000333-41-5
         HEXAHETHYLENE DIAHINE    000460-19-5
          DIBROMOCHLOROMETHANE    000479-45-8
             METHACRYLONITRILE    000496-72-0
      CHLORO-1,3-BUTADIENE, 2-    000504-24-5
                   CHLOROPRENE    000506-61-6
           TETRACHLOROETHYLENE    000506-64-9
                        PYRENE    000506-68-3
          NAPHTHOQUINONE, 1,4-    000506-77-4
             OIMETHYLPHTHALATE    000507-20-0
                  OIBENZOFURAN    000510-15-6
                        CAPTAN    000512-56-1
                        FOLPET    000526-75-0
                        THIRAM    000528-29-0
                     PROPAZINE    000531-82-8
                       ARAHITE    000532-28-5
                ETHYL ACRYLATE    000534-52-1
                 ETHYL ACETATE
         OICHLOROPROPANE, 1,3-    000540-73-8
                   HEPTANE. N-    000541-73-1
                SODIUM CYANIDE    000542-62-1
                     ENDOTHALL    000542-75-6
  SODIUM DIETHYLDITHIOCARBAMATE    000542-75-6
                       MERPHOS    000542-88-1
             POTASSIUM CYANIDE    000542-92-7
    OCTAMETHYLPYROPHOSPHORAMIDE    000544-92-3
       NITROSODIPHENYLAMINE, P-    000557-19-7
       DICHLOROETHYLENE,  1,2-C-    000557-21-1
       DICHLOROETHYLENE,  1,2-T-    000563-68-8
         INDENOM.2.3-CD1PYRENE    000573-56-8
           BENZOCB1FLUORANTHENE    000576-24-9
                   FLUORANTHENE     000576-26-1
           BENZOCK1FLUORANTHENE     000583-78-8
                  ACENAPTHYLENE     000586-11-8
                       CHRYSENE     000591-27-5
               METHYL PARATHION     000591-35-5
                        PHORATE     000591-78-6
                     DISULFOTON     000592-01-8
                         RONNEL     000593-60-2
                      HYDRAZINE     000593-60-2
    ANTIMONY POTASSIUM TARTRATE     000594-20-7
                         ALDRIH     000598-31-2
DIETHYL-P-NITROPHENYL PHOSPHATE     000598-77-6
  HEXACHLOROCYCLOHEXANE.  ALPHA-     000598-94-7
   HEXACHLOROCYCLOHEXANE,  BETA-     000602-01-7
                                      Nay 1995

                  HEXACHLOROCYCLOHEXANE,  DELTA-
                            DINITROPHENOL, 2,5-
                                        LINURON
                                      DIAZINON
                                      CYANOGEN
                  TRINITROPHENYLMETHYLNITRANINE
                           TOLUENEDIAMINE, 3,4-
                              AMINOPYRIDINE, 4-
                       POTASS1UM SILVER  CYANIDE
                                 SILVER  CYANIDE
                               CYANOGEN  BROMIDE
                               CHLORINE  CYANIDE
                              BUTYLCHLORIOE, T-
                                CHLOROBENZILATE
                            TRIMETHYL PHOSPHATE
                           D1METHYLPHENOL, 2,3-
                           DINITROBENZENE, 1,2-
                                         FURIUM
                       BENZALDEHYDE CYANOHYDRIN
                         DINITRO-0-CRESOL, 4.6-
000540-59BOCHLOROETHYLENE. 1,2- (NIXED ISONERS)
                        DIMETHYLHYDRAZINE, 1,2-
                          DICHLOROBENZENE. 1.3-
                                 BAR1UM CYANIDE
                                      TELONE  II
                          DICHLOROPROPENE, 1,3-
                        BIS(CHLOROMETHYL) ETHER
                                CYCLOPENTAOIENE
                                 COPPER CYANIDE
                                 NICKEL CYANIDE
                                   ZINC CYANIDE
                           THALLIUM (I) ACETATE
                            DINITROPHENOL, 2,6-
                           DICHLOROPHENOL, 2,3-
                           DIMETHYLPHENOL, 2,6-
                           DICHLOROPHENOL, 2,5-
                            DINITROPHENOL, 3,5-
                                AMINOPHENOL,  N-
                           DICHLOROPHENOL, 3,5-
                                   HEXANONE,  2-
                                CALCIUM  CYANIDE
                                   VINYL  BROMIDE
                                    BROMOETHENE
                          DICHLOROPROPANE,  2,2-
                                   BROMOACETONE
                        TRICHLOROPROPANE,  1.1,2-
                              DIMETHYLUREA,  N,N-
                            DINITROTOLUENE,  2,3-
                                                                                                                                          CASRN/NAME-3

-------
CHEMICAL ABSTRACTS SERVICE REGISTRY  NUMBER AND CHEMICAL NAME  CROSS  REFERENCE
            (LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER)  continued
                                                                        May 1995
000606-20-2                DINITROTOLUENE, 2,6-
000608-73-1     HEXACHLOROCYCLONEXANE-TECHNICAL
000608-93-5                  PENTACNLOROBENZENE
000609-19-8             TRICHLOROPHENOL, 3,4.5-
000609-93-8              DINITRO-P-CRESOL. 2,6-
000610-39-9                DINITROTOLUENE. 3.4-
000611-14-3                    ETHYLTOLUENE. 0-
000615-54-3             TRIBROHOBENZENE. 1.2.4-
000617-84-5                    DIETHYLFORMAMIDE
000619-15-8                DINITROTOLUENE, 2.5-
000620-14-4                    ETHYLTOLUENE, N-
000621-64-7        NITROSO-DI-N-PROPYLAMINE. N-
000622-96-8                    ETHYLTOLUENE, P-
000624-83-9                   METHYL  ISOCYANATE
000630-05-0                     CARBON MONOXIDE
000630-10-4                           SELENOUREA
000630-20-6         TETRACHLOROETHANE, 1.1,1,2-
000634-93-5            TRICHLOROANILIHE. 2,4.6-
000636-21-5     METHYLANILINE HYDROCHLORIDE, 2-
000684-93-5            NITROSO-N-METHYLUREA. N-
000695-77-2          TETRACHLOROCYCLOPENTADIENE
000759-73-9             NITROSO-N-ETHYLUREA. N-
000759-94-4                                EPTC
000764-41-0             DICHLORO-2-BUTENE, 1,4-
000765-34-4                       GLYCIDALDEHYDE
000823-40-5                  TOLUENE-2.6-DIANINE
000834-12-8                             ANETRYH
000924-16-3         NITROSO-DI-N-BUTYLAMINE, N-
000930-55-2              NITROSOPYRROLIDINE, N-
000933-75-5             TRICHLOROPHENOL. 2.3,6-
000933-78-8             TRICHLOROPHENOL. 2,3,5-
000934-80-5                  ETHYL-0-XYLEHE. 4-
000935-95-5         TETRACHLOROPHENOL. 2,3,5,6-
000950-10-7                         MEPHOSFOLAN
000961-11-5                  TETRACHLOROVINPHOS
000961-11-5                           STIROPHOS
001024-57-3                  HEPTACHLOR EPOXIDE
001114-71-2                            PEBULATE
001116-54-7            NITROSODIETHANOLAMINE. N-
001134-23-2                            CYCLOATE
001163-19-5             DECABROMODIPHENYL ETHER
001198-27-2    ANINO-2-NAPHTOL HYDROCHLORIDE, 1-
001309-64-4                   ANTIMONY TRIOXIDE
001314-32-5                        THALLIC OXIDE
001314-60-9                  ANTIMONY PENTOXIDE
001314-62-1                  VANADIUM PENTOXIDE
001314-84-7                       ZINC PHOSPHIDE
001330-20-7                     XYLEHE, MIXTURE
                    001332-21-4                            ASBESTOS
                    001332-81-6                  ANTIMONY  TETROXIDE
                    001336-36-3            POLYCHLORINATEO  BIPHENYLS
                    001338-23-4         METHYL  ETHYL  KETONE PEROXIDE
                    001563-66-2                          CARBOFURAN
                    001569-02-4     PROPYLENE GLYCOL  MONOETHYL  ETHER
                    001582-09-8                          TRI PLURAL IN
                    001600-37-9      PENTACHLOROPROPENE,  1.1,2,3,3.-
                    001615-80-1              DIETHYLHYDRAZINE.  1.2-
                    001689-84-5      001689-99-2BROMOXYN1L  OCTANOATE
                    001746-01-6                       TCDD, 2.3,7.8-
                    001861-32-1                              DACTHAL
                    001861-40-1                              BENEF1N
                    001897-45-6                       CHLOROTHALONIL
                    001912-24-9                            ATRAZINE
                    001918-00-9                              DICAMBA
                    001918-16-7                          PROPACHLOR
                    001929-77-7                            VERNOLATE
                    001929-77-7                              VERNAM
                    001937-37-7                      DIRECT BLACK 38
                    002008-41-5                            BUTYLATE
                    002014-83-7         TRICHLOROTOLUENE. ALPHA,2,6-
                    002077-46-5             TRICHLOROTOLUENE, 2.3,6-
                    002104-96-3                            BROMOPHOS
                    002212-67-1                            MOLINATE
                    002303-16-4                            DIALLATE
                    002303-17-5                            TR1ALLATE
                    002370-63-0         ETHOXYETHYL METHACRYLATE, 2-
                    002385-85-5                                MIREX
                    002425-06-1                            CAPTAFOL
                    002429-74-5                      NIAGARA  BLUE 4B
                    002491-38-5                            BUSAN 90
                    002602-46-2                        DIRECT BLUE 6
                    002610-05-1                   DIRECT  SKY  BLUE 6B
                    002687-25-4                 TOLUENEDIAMINE. 2,3-
                    002834-92-6                 AMINO-2-NAPHTHOL, 1-
                    002921-88-2                         CHLORPYR1FOS
                    003165-93-3
                            CHLORO-2-METHYLANILINE HYDROCHLORIDE, 4-
                    003175-23-3             TRICHLOROPROPANE, 1,2.2-
                    003380-34-5
                          TRICHLORO-2'-HYDROXYDIPHENYLETHER,  2,2,4'-
                     003383-96-8
                     003689-24-5
                     004399-55-7
                     004549-40-0
                     004901-51-3
                     005216-25-1
                      TEMEPHOS
TETRAETHYL DITHIOPYROPHOSPHATE
         DIRECT L1GHTFAST BLUE
    NITROSOMETHYLVINYLAM1NE,  N
   TETRACHLOROPHENOL, 2,3.4,5-
 TETRACHLOROTOLUENE, PARA. ALPHA, ALPHA, ALPHA-
005598-13-0                 CHLORPYRIFOS METHYL
006108-10-7     HEXACHLOROCYCLOHEXANE. EPSILON-
006533-73-9              THALLIUM (I) CARBONATE
007429-90-5                            ALUMINUM
007439-89-6                                IRON
007439-92-1                                LEAD
007439-96-5                           MANGANESE
007439-97-6                  MERCURY, ELEMENTAL
007439-98-7                          MOLYBDENUM
007440-22-4                              SILVER
007440-24-6                   STRONTIUM, STABLE
007440-36-0                  ANTIMONY, METALLIC
007440-38-2                  ARSENIC, INORGANIC
007440-39-3                              BARIUM
007440-41-7                           BERYLLIUM
007440-42-8                    BORON, ELEMENTAL
007440-43-9                             CADMIUM
007440-50-8                              COPPER
007440-62-2                            VANADIUM
007440-66-6                      ZINC (METALLIC)
007446-09-5                      SULFUR DIOXIDE
007446-18-6                THALLIUM (I) SULFATE
007446-34-6                    SELENIUM SULFIDE
007487-94-7                   MERCURIC CHLORIDE
007637-07-2                   BORON TRIFLUORIDE
007664-41-7                             AMMONIA
007664-93-9                       SULFUR1C ACID
007723-14-0                   PHOSPHORUS, WHITE
007782-41-4       FLUORINE  / (SOLUBLE FLUORIDE)
007782-49-2                            SELENIUM
007783-00-8                      SELENIOUS ACID
007783-06-4                    HYDROGEN SULFIDE
007789-89-1             TRICHLOROPROPANE, 1,1,1-
007791-12-0                THALLIUM (I) CHLORIDE
007803-51-2                           PHOSPHINE
008001-35-2                           TOXAPHENE
008001-58-9                  CREOSOTE, COAL  TAR
008007-45-2                 COKE OVEN EMISSIONS
008018-01-7                            MANCOZEB
010028-15-6                               OZONE
010034-93-2                   HYDRAZINE SULFATE
010102-43-9                        NITRIC OXIDE
010102-44-0                    NITROGEN DIOXIDE
010102-45-1                THALLIUM  (I) NITRATE
010436-39-2         TETRACHLOROPROPENE,  1,1,2,3-
010595-95-6          NITROSOMETHYLETHYLAMINE,  N-
010599-90-3                      MONOCHLORAMINE
                                                                                                           CASRN/NAME-4

-------
                              CHEMICAL  ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
                                          (LISTED BY  CHEMICAL ABSTRACTS REGISTRY NUMBER)  continued
                                                                                                                                    Nay 1995
011097-69
012035-72
012039-52
012122-67
012427-38
012672-29
013071-79
013194-48
013196-18
013718-26
014797-65
015950-66
015972-60
016065-83
016071-86
016752-77
018540-29
020816-12
020859-73
021087-64
021232-47
021436-96
021564-17

021725-46
022967-92
023950-58
025013-15
025329-35
026399-36
030560-19
031512-74
032534-81
032536-52
033663-50

033820-53
036907-42
039638-32
040487-42
041851-50
051218-45
059756-60
060238-56
068554-00
071753-42
077323-84
VARIOUS
 1                        AROCLOR 1254    NO CASRN
 2                   NICKEL SUBSULFIDE    NO CASRN
 0                   THALLIUM SELENITE    NO CASRN
 7                               ZINEB    NO CASRN
-2                               NANEB    NO CASRN
 6                        AROCLOR 1248    VARIOUS
 9                            TERBUFOS    NO CASRN
 4                            ETHOPROP    NO CASRN
-4                           THIOFANOX    NO CASRN
-8                 SODIUM NETAVANADATE    NO CASRN
-0                             NITRITE    NO CASRN
-0             TRICHLOROPHENOL, 2,3,4-    NO CASRN
-8                            ALACHLOR    NO CASRN
-1                       CHRONIUN(III)    NO CASRN
i-6                     DIRECT BROUN 95    NO CASRN
'-5                            NETHONYL    NO CASRN
-9                        CHROMIUM(VI)    NO CASRN
 0                    OSMIUM TETROXIDE
-8                  ALUMINUM PHOSPHIDE
-9                          METRIBUZIN
-3             TETRACHLOROAZOXYBENZENE
-4 DIMETHYLANILINE HYDROCHLORIDE, 2.4-
-0
THIOCYANOMETHYLTHIO)BENZOTHIAZOLE, 2-(
                             CYANAZINE
                        METHYL MERCURY
                             PRONAMIDE
        METHYL STYRENE (MIXED ISGMERS)
            PENTACHLOROCYCLOPENTADIENE
                           PROFLURALIN
                              ACEPHATE
                              BUSAN 77
              PENTABROMODIPHENYL ETHER
               OCTABROMODIPHENYL ETHER
-2
-6
-5
-4
-5
-0
-1
-0
-9
-0
-2
TRICHLOROANILINE HYDROCHLORIDE, 2.4,6-
-0                         ISOPROPALIN
-3                    VANADIUM SULFATE
-9        BIS(2-CHLOROISOPROPYL) ETHER
-1                       PENDIMETHALIN
-7               CHLOROCYCLOPENTADIENE
-2                         METOLACHLOR
-4                           FLURIDONE
-4                       CHLORTHIOPHOS
-7         ETHOXYETHANOL PHOSPHATE, 2-
-9           TETRACHLOROHYDRAZOBENZENE
-3            TRICHLOROCYCLOPENTADIENE
              BROMIMATED DIBENZOFURANS
                                                             BROMINATED DIBENZO-P-DIOXINS
                                                                       BROMOCHLOROETHANES
                                                                          DICHLOROBUTENES
                                                                              LEAD ALKYLS
                                                                    NICKEL.  REFINERY DUST
                                                                    NICKEL.  SOLUBLE SALTS
                                                                          NITROGEN OXIDES
                                                                             NITROPHENOLS
                                                                       PARTICIPATE MATTER
                                                                   PHOTOCHEMICAL OXIDANTS
                                                                 POLYBROMINATED BIPHENYLS
                                                                            SULFUR OXIDES
                                                                THALLIUM,  INSOLUBLE SALTS
                                                                        TIN  AND COMPOUNDS
                                                                        TRIMETHYLBENZENES
                                                                          TRINITROPHENOLS
                                                                   URANIUM,  SOLUBLE SALTS
                                                                                                                                          CASRN/NAME-5

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                                APPENDIX A-IV

                        IV. EFFECT LEVEL DEFINITIONS
Adverse effect.  A biochemical change, functional impairment, or pathologic lesion that
either singly or in combination adversely affects the performance of the whole
organism, or reduces an organism's ability to respond to an additional environmental
challenge.

Frank-effect-level (FELV The exposure level at which there are statistically or
biologically significant increases in frequency or severity of severe effects between the
exposed  population and its appropriate control group. These severe effects produce an
unmistakable adverse health effect (such as severe convulsions or death).

Lowest-observed-adverse-effect level (LOAEU. The lowest exposure level at which
there are statistically or biologically significant increases in frequency or severity of
adverse effects between the exposed population and its appropriate control group.

Lowest-observed-effect level (LOEL). The lowest exposure level at which there are
statistically or biologically significant increases in frequency or severity of any effects
between  the exposed population and its appropriate control group. The effects that are
seen at this level may or may not be considered as adverse.

No-observed-adverse-effect level (NOAEL). An exposure level at which there are no
statistically or biologically significant increases in the frequency or severity of adverse
effects between the exposed population and its appropriate control; some effects may
be produced  at this level, but they are not considered to be adverse.

No-Qbserved-effect level (NOELV  An exposure level at which there are no statistically
or biologically significant increases in the frequency or severity of any effect between
the exposed population and its appropriate control.
Adapted from: U.S. EPA.  1991. Integrated Risk Information System (IRIS). Online.
National Center for Environmental Assessment, Cincinnati, OH.
                                      A-21

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                               APPENDIX A-V

         V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
      The Clean Air Act requires that National Ambient Air Quality Standards (NAAQS)
be set and ultimately met for any air pollutant which, if present in air, may reasonably be
anticipated to endanger public health or welfare and whose presence in the air results
from numerous or diverse mobile and/or stationary sources. Since the primary NAAQS
and the inhalation RfC serve essentially the same function, and the primary NAAQS
have extensive data bases rigorously reviewed, the primary NAAQS with annual
averaging times should be used in lieu of an inhalation RfC, except for lead.  In deriving
a risk assessment number for lead (Pb), the Integrated Exposure Uptake Biokinetics
(IEUBK) model should be used instead of the RfC. Primary standards are designed to
protect public health and secondary standards are designed to protect public welfare.
Each primary NAAQS has either one or two averaging times depending on the health
effects of the chemical. To date, six NAAQS have been established: Carbon Monoxide
(CO), Lead (Pb), Nitrogen Dioxide (NO2), Particuiate Matter, less than 10 Mm in size,
(PM10), Ozone (O3) and Sulfur Dioxide (SO2). A table of the most recent NAAQS is
provided as Table A-V-1.

      The process of establishing and revising the NAAQS is detailed by Padgett and
Richmond (Journal of the Air Pollution Control Association, 33:13-16, 1983).  The
primary NAAQS are solely health based and designed to protect the most sensitive
group of individuals (but not necessarily the most sensitive members of that group)
against adverse health effects. Thus, by definition, the NAAQS primary standards
define allowable pollutant concentrations which can be present in the atmosphere
without causing adverse effects,  and essentially serve the same function as an
inhalation RfC in a risk assessment/risk management decision, except for lead. The
data bases supporting each of the NAAQS are extensive. More importantly, the
NAAQS are set by the USEPA Administrator as mandated by Congress after numerous
reviews and a public comment process.
                                    A-23

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TABLE A-V-1
NATIONAL AMBIENT AIR QUALITY STANDARDS'
(as of December 2, 1991)
Pollutant
Carbon monoxide (CO)
Lead (Pb)
(and Lead compounds
Nitrogen dioxide (N02)
(Nitrogen oxide)
(Nitric oxide)
Particulate Matter
(PM10)
Ozone (O3)
Sulfur dioxide (SO2)
(Sulfur oxide)
Primary Standards"
9 ppm (10 mg/m3)
35 ppm (40 mg/m3)
1.5 Mg/m3
0.053 ppm
(100 Mg/m3)
50 pg/m3
150 Mg/m3
0.12 ppm
(235 Mg/m3)
0.03 ppm
(80 Mg/m3)
0.14 ppm
(365 Mg/m3)
—
Averaging
Time
8 hour0
1 hour0
Quarterly
Annual
Annual"
24 hours6
1 hourf
Annual
24 hours0
3 hours0
Secondary
Standards'1
None
Same as primary
Same as primary
Same as primary
Same as primary
» —
—
0.5 ppm
(1300M9/m3)
•Source:  U.S. EPA 1991. Subchapter C - Air Programs. Part 50 -National Primary and
 Secondary Ambient Air Quality Standards. Code of Federal Regulations 50: 693-697.
 Revised 7/1/91.

"Primary standards are designed to protect public health; Secondary standards are designed to
 protect public welfare.

°Not to be exceeded more than once per year.

''The standard is attained when the expected annual arithmetic mean concentration is less than
 or equal to 50
The standard is attained when the expected number of days per calendar year with a 24-hour
 average concentration above 150 Mg/m3 is equal to or less than 1.

The standard is attained when the expected number of days per calendar year with maximum
 hourly average concentrations above 0.12 ppm is equal to or less than 1.
                                         A-24
                                                  •U.S. GOVERNMENT PRINTING OFFICE: 1995-386-541/23016

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