United States
            Environmental Protection
            Agency
             Environmental Research
             Laboratory
             Duluth MN 55804
EPA/600/3-86/008
March 1986
            Research and Development
£EPA
A Toxicity
Evaluation of Lower
Fox River Water and
Sediments

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                                             EPA/600/3-86/003
                                             March 1986
A Toxicity Evaluation of Lower Fox River Water and Sediments
                             By
 Gregory J. Lien, Kenneth E. Biesinger, Leroy E. Anderson,

         Edward N. Leonard, and Michael A. Gibbons
                        ERL-DUL-1043
            U.S. Environmental Protection Agency
          Environmental Research Laboratory-Duluth
                   6201 Congdon Boulevard
                     Duluth, MN  55804

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                        NOTICE

This document has been reviewed in accordance with U.S.
Environmental Protection Agency policy and approved for
publication.  Mention of trade names or commercial products
does not constitute endorsement or recommendation for use.
                            11

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                                 Abstract







     Many persistent,  xenobiotic  compounds  have  been  identified  from Lower




Fox River water, biota,  sediment, and  effluent  discharges;  some of which are




suspected of causing adverse effects to aquatic organisms.




     Water and  sediment  were collected  as grab  samples  from  the  Lower  Fox




River in late  January,  in mid-March, and  in late  April,  1985.   Samples were




transported to  the Environmental  Research  Laboratory-Duluth  (ERL-D)  and  a




determination of their potential toxicity was accomplished through laboratory




bioassays using  four  freshwater invertebrates and  one freshwater vertebrate.




     Results from  the  present  toxicity evaluation  of Lower Fox  River water




and sediment indicate  a  general  absence of  lethal  effects  as  defined by the




bioassays used and within the framework of the  study.  Significant sublethal




effects were  recorded  in  the  form  of  reduced  growth  or  fewer  progeny,




however, the effects were  not  observed for more  than one species or testing




period and no pattern was evident from this analysis.
                                  111

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                                 Contents


                                                                 Page

Abstract                                                          iii


List of Figures                                                    vi


List of Tables                                                    vii


Acknowledgments                                                 viii


   I   Introduction                                                1

  II   Materials and Methods                                       2
         Site Selection
         Sampling Protocol
         Chemical Analysis
         Bioassay Methods
         Statistical Analysis
         Quality Assurance

  III  Results                                                     15
         Physical/Chemical Conditions
         Biological Effects

  IV   Summary                                                     24

   V   Discussion                                                  25

  VI   References                                                  26
                                     v

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Number
                                Figures
           Map of Study Area and Locations of Sampling
           Stations for Toxicity Evaluation of Lower Fox
           River Water and Sediments.
                                   VI

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                                Tables
Number                                                              Page

  1      Summary of Test Conditions for Bioassay Experiments.          8

  2      Physical and Chemical Data for Water Collected from         16
         the Lower Fox River at Various Locations and Dates.

  3      Mean Percent Survival of Daphnia magna Exposed to Lower     18
         Fox River Water for 48 hrs.

  4      Survival and Growth of Pimephales promelas Exposed to       19
         Lower Fox River Water for Seven Days.

  5      Survival and Reproduction of Ceriodaphnia dubia Exposed     20
         to Lower Fox River Water.

  6      Survival and Reproduction of Daphnia magna in Elutriate     21
         Tests.

  7      Mean Percent Survival of Daphnia magna, Hyalella azteca     22
         and Ephemerella sp. in Solid Phase Tests.

  8      Reproduction of Daphnia magna in Solid Phase Tests.         23
                                   VI1

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                               Acknowledgements







     The authors  wish  to acknowledge  the  assistance  of  Floyd  Boettcher  in




collection of field samples, the drafting of figures by Barbara Halligan, the




identification of  Ephemerella  by Douglas Jensen,  and the review  of earlier




drafts by Kenneth Hokanson.
                                     Vlll

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                               INTRODUCTION




     The Lower  Fox  River in  northeastern Wisconsin  is  approximately  64  km




(40 miles) long  and  extends from the outlet  of  Lake  Winnebago to Green Bay.




This river is a major tributary to  Green  Bay, draining an  area of 11,752 km^




(~ 7%  of  the total  drainage  area  of Lake Michigan).  The  fall  of the Lower




Fox River  from  its  headwaters  at  Lake  Winnebago to  its  mouth at  Green Bay




averages 1.3 meters per mile-*- and its flow is controlled by 11 dams, with the




last dam occurring 11.7  km  upstream from the mouth.   The  river  is navigable




through a series of locks.




     The Lower Fox River is one of the most industrialized in the country re-




ceiving input  from  14  pulp  and/or paper   mills,  an  electric  generating




facility and  8  municipal wastewater  treatment  plants  serving approximately




250,000 people.   Lake Winnebago,  a hypereuthropic  lake,  is a major  contri-




butor of nutrients entering the river.




     Until recently  the  Lower  Fox River  was one  of the  10 most  polluted




rivers in  the United  States.  Concerted  efforts  by  the  Fox Valley  Water




Quality Planning Agency  and  the  Wisconsin Department  of   Natural  Resources




(WDNR) to  clean up the  river have  reduced  the  organic wastes  by 90%;  the




final cleanup to meet the standards set  by Section 208 of the Clean Water Act




is underway.   Persistent,   xenobiotic  compounds  continue  to  be  a  problem,




however.  A total of  105 organic  compounds have  been  identified  from biota,




water, sediment, and effluent discharges^.  Many of these chemicals are known




to be toxic and/or bioaccumulate and are suspected of causing adverse effects




to aquatic organisms.  Toxics (via suspended solids,  biota,  and  water) from




the Lower  Fox River  enter  Green  Bay at Green  Bay, Wisconsin.  The  zone  of




impact on the water quality of  Green Bay extends as  far at 15.5 km into the




bay 3.




                                    1

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     A previous study was  conducted  by personnel of the ERL-D to measure the




total toxicity of industrial and municipal wastewater treatment effluents and




their receiving waters  from  the  Lower Fox River^.  They  could not attribute




the toxicity they  found to any one effluent.  The present  study  was made to




determine if there  was   instream  toxicity and if  bottom sediments  from the




Lower Fox River were  toxic.   Water and sediment samples  were  collected from




several stations (Fig.  1) in the Lower Fox River and transported to ERL-D for




testing.




     Acute tests were performed  using  Daphnia magna  on river aliquots and




elutriate water.  A 10  day I),  magna chronic test was  conducted  on elutriate




waters.  A seven day  Ceriodaphnia  dubia life  cycle test  and a  seven day fat-




head minnow  (Pimephales  promelas) subchronic  test  were  conducted  on river




aliquots.  Ten  day  tests for  solid  phase  sediment  toxicity  were conducted




using I), magna, Hyalella azteca and Ephemerella sp.












                          MATERIALS AND METHODS




Site Selection




     Sampling sites on the Lower  Fox River were  selected in an effort to ob-




tain an indication of instream toxicity,  avoiding  effluent plumes and immed-




iate mixing  zones as  much  as possible.  Consideration was  also  given to the




accessibility of the  possible  sites  under both winter  and  spring conditions




and the availability of  sediment  in the immediate area  of the  water sampling




site.  A station in Lake Winnebago (M)  or a station in  the  river system up-




stream of any known point  source  discharges (L) were  selected  for "reference




stations" for these experiments.

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                         mi
                      5     10
 I. RKM39.9
 J. RKM 45.4 .
K. RKM  52.8
                                          A. Mouth.
                                        C- RKM 2.6.

                                      D. RKM 4.a
                                    F. RKM 10.5.
                                  G. RKM II.I
L. RKM 63.2	
     8. RKM 1.0
	E. RKM 7.6
                                                                H. RKM 28.3
                                 .M. Lake W
 Figure  1.   Map of Study Area and Locations  of Sampling Stations for Toxi-

             city Evaluation of Lower Fox  River Water and  Sediments (RKM =

             river kilometers).

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Sampling Protocol




     Water and sediment for bioassays and chemical analyses were collected as




grab samples from the Lower Fox  River,  Wisconsin, and from Lake Winnebago in




late January,  in mid-March,  and again  in  late  April,  1985.    Samples  were




obtained through holes drilled  in the  ice  for the January  sampling period.




Holes were  hand drilled  to  avoid  possible contamination  from power  auger




equipment.




     All glassware used for  collection, transportation and  storage  of water




samples was  washed  with  detergent,   rinsed  with tap water,  distilled  water,




acetone, and hexane  and  then drained  before  being  rinsed  twice  with  one




gallon aliquots  of  river  water  from the respective stations.   Water samples




were obtained from ~ 2 feet below the surface using a 1 gallon glass "jug-on-




a-stick" and were  then transferred   immediately to  a  19 liter  glass bottle.




All bottles were filled to exclude air  and  the  covers  were lined with alumi-




num foil.  All containers were labeled at the time of collection.




     A sample of water from each station was poured into a pre-cleaned 250 ml




polyethylene bottle which  contained  0.5 ml of 2N  zinc acetate  for sulfide




analysis.  Three  liter  water  samples  from  each  site  were  poured  into




calibrated, solvent rinsed  glass bottles each  of which contained  100  ml  of




(1:1) hexane/methylene  chloride  mixture.    These  samples  were stored  for




possible future organic analysis.




     Within 36  hours  after collection  all   samples  were transported  to  the




laboratory and placed  in a constant-temperature room  which was maintained at




4° C.  During transport from the field collection site to the laboratory, all




samples were maintained at  temperatures above  freezing  but  below final test




temperature.

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     Sediment samples were obtained from 11 locations (A-G, I-L) in the Lower




Fox River and  1  station in Lake Winnebago (M)  as  grab  samples using a stan-




dard size Ekman  dredge.  The  nature  of  the  bottom (i.e., hard,  rocky)  and




accessibility precluded  sampling  for  sediment  at some  of the  sites.   The




depth of the river varied from  0.9 to  7.6 m.  at the sites the sediments were




obtained.  Bottom material  from each  site was transferred  from  the dredge




into pre-cleaned  one  gallon wide-mouth  glass containers  with  foil  lined




covers.  Sediment samples were  then transported and stored  in  the same manner




as the water samples.




     Upon return to the laboratory the following sample splits were made:   A)




250 ml subsamples of  test  water were poured  into  clean polyethylene bottles




and acidified to 0.2%  with HNO-j in  order to preserve  the  samples  for metal




analysis; B) 250 ml subsamples  of test water were  poured into  clean polyethy-




lene bottles and kept  in the dark  at 4° C for  analysis of nitrate, nitrite,




phosphate, chloride and  sulfate.   Upon completion of the anion analysis,  the




remainder of the sample was frozen and stored for  future ammonia analysis; C)




250 ml subsamples of  test  water were poured  into  clean polyethylene bottles




for pH, alkalinity,  hardness and conductivity measurements.




Chemical Analysis




     The pH  was  measured at  20° C  according  to  EPA  Method  150.15  using  a




Beckman model <5 70 pH meter  standardized  with pH 7.0 and 10.0 buffers before




use.  The  conductivity  was  measured  at  20°  C  according   to  EPA  Method




120.1-*, using  a  YSI  model  31  conductivity  meter.    Water  hardness  was




measured according  to  EPA  Method  130.2^.    One  hundred  ml  aliquots   of




samples were titrated  with  0.01 M EDTA to  a  blue  endpoint   at pH  10  using




Eriochrome Black T  as  an  indicator.   Alkalinity  was  measured  according to




EPA Method 310.1^.   One hundred ml  aliquots of  samples were titrated  with




                                    5

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0.02 N sulfuric  acid  to pH  4.4  endpoint  using a Beckman model  5 70 pH meter



which was  standardized  with pH  7.0  and  10.0 buffers  before use.   Dissolved



oxygen was measured  using  a  Beckman 0260 Oxygen  Analyzer  according  to the



manufacturer's instructions", Method 6.1.4.2, which  specifies  air-saturated



water to calibrate the instrument.



     Sulfides were analyzed  according to  EPA Method  376.1^.   Iodine solution



(0.025N) was added to 200 ml aliquots of  water samples preserved  with zinc



acetate which were then  titrated to a blue  endpoint with 0.025 N  PAO using



starch as an indicator.


               —      —      — 3     —      — 9
     Anions (CL  , N0£ , PO^  ,  NO 3  , SO^  )  were  measured  according  to EPA



Method 300.0^ employing a model  12 Dionex  (R) ion  chromatography system with



a Gilson (R) automatic  sample changer.   Five ml aliquots were  placed in 12



X 75 mm plastic test  tubes,  capped with aluminum foil and placed in the auto-



matic sample changer.  All  standard  conditions  were as specified in  the EPA



method with the  conductivity detector set  at  the 300 umho  range, pump  volume



at 2.5 ml/min.  and sample loop volume at  1000 microliters.



     Ammonia was measured on the ion  chromatography system  also;  the manu-



facturers recommendations"  for   column  types,  eluent,  and  regenerant  were



followed.  Operating  conditions  for ammonia analysis were as  follows:  Columns



- 4 x 50 mm cation precolumn (Dionex P/N 030830), 4 X 250 mm cation separator



column (Dionex  P/N  030831),  cation  fiber suppressor  (Dionex   P/N  036179);



detector - conductivity at  30 pmho  scale;  eluent - 0.003  N HCL; regenerant -



0.040 M  TMAOH  (Tetramethylammoniumhydroxide  pentahydrate)  at   3.1  ml/min.;



sample loop - 500 microliters; pump volume - 2.5 ml/min.



     At least one in  ten  samples were  analyzed in duplicate for  both anion



and ammonia (cation)   analysis as  a  check  on  the precision  of the procedures.

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Environmental Monitoring and Support Laboratory  (EMSL) quality assurance  (QA)




samples were analyzed in each analytical run for all ions, except nitrite, as




a check for the accuracy of the methods.  There was no known QA sample avail-




able for  nitrite  at  the time of  analysis.   A separate  nitrite  standard was




analyzed  in each  analytical  run as a  check for any oxidation  of nitrite to




nitrate in the mixed  standards.   No  oxidation  was  observed in this standard.




At least  one river sample for each analytical run was spiked with an anion or




ammonia standard to insure that no matrix effects were present.




Bioassay Methods




     A determination  of the  potential toxicity  of  water  and  sediments   from




the Lower Fox  River  was accomplished using  four freshwater invertebrates and




one freshwater  vertebrate  in the  following  laboratory  bioassays:   a Daphnia




magna acute toxicity  test;  a Daphnia magna  life cycle  toxicity  test;  a  sub-




chronic fathead  minnow  (Pimephales  promelas)   toxicity  test; a  life  cycle




toxicity test using Ceriodaphnia; and a Hyalella and Ephemerella 10 day test.




The species  tested,   stage  of  development,  medium, type  of test,  measured




response, duration,  renewal,  test  solution volume,  number  of   animals  per




replicate, number  of  replicates per treatment,  food added,  and  the tempera-




ture for these tests are given in Table 1.




     All animals used in the bioassays were obtained from ERL-D culture stock




with the  exception  of the  Ephemerella which were  collected from  the  Sucker




River in  northeastern  Minnesota.   Test organisms  were   cultured at  the  same




temperature as  the  test temperature with the  exception of  the  Ephemerella,




which were acclimated over a period of  7 days  from an  initial  temperature of




4° C to  the  eventual  test  temperature of  20°  C.   The  photoperiod and  the




feeding regimes were identical for both the  culturing and the testing period.

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     Acute tests  were chosen as an  initial  screening process.  In addition,




sub-chronic, partial  life  cycle,  and  life  cycle  tests  were  conducted  to




determine possible effects on survival, growth, or reproduction.




     Test temperatures  were  maintained by partially  submerging the chambers




containing the water  and/or sediment and the test organisms into thermostati-




cally controlled  water  baths.   A photoperiod of  16 hours  was maintained for




both the culture  and  exposure of test organisms.  Water quality was routinely




monitored to ensure  it's  adequacy  for  the  test  organisms.   Test chambers for




the ]). magna  acute  tests,  Ceriodaphnia life  cycle  tests  and  the elutriate




bioassays were covered with glass to minimize evaporation.




     All containers  and  other  equipment  coming  in  contact  with  test water




and/or sediment used  in these  bioassays were constructed  of  glass or stain-




less steel.  The  cleaning protocol for all containers  and equipment  used in




the laboratory  for  these tests  included a  detergent  wash  followed by three




tap water  rinses, three  distilled  water  rinses, an  acid (10% HNO^)  rinse




followed by  another   three  distilled  water  rinses,  an  acetone  rinse,  and




finally by three  distilled water rinses.




     Individual bioassay  procedures  are described below  for  laboratory  bio-




assays conducted  with river water,  liquid  phase  elutriate and solid phase.




A)  Lower Fox River Water




    Tests were conducted  using Lower Fox River  and Lake Winnebago  water that




had been stored at  4° C  for not more  than 7 days.   Prior to being utilized




for the bioassays described, a portion of the test water  was rapidly warmed




each day to test temperature and the water was then aerated briefly to stabi-




lize dissolved gas concentrations.

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    1)  Daphnia magna Acute Test

    An evaluation of  the acute toxicity  of  Lower Fox  River  water was  con-

ducted using  the protocol  established  by  EPA".   Culturing,  handling  and

glassware cleaning  procedures  as  outlined  by  EPA  were  followed  with  the

exception of a dilution  water  rinse,  due to the  small  amount of  test  water

transported to and  stored  at  the  laboratory.   The  test  solution  was  not

renewed over the 48 hour period.

    At the end of 24 and 48 hours the number of living  daphnids  were  counted

and recorded.

    2)  Fathead Minnow (Pimephales promelas)  Sub-chronic Test.

    The method described by Norberg and Mount 1"  for measuring  growth  and sur-

vival of newly-hatched fathead  minnow larvae  was  used for evaluating  the sub-

chronic effects  of  toxicants.   Test  chambers were modified to provide  sepa-

rate chambers  for each of the  replicates.  All chambers were  placed  randomly

in a temperature controlled bath.  The test  chambers measured 6  cm x  18 cm x

9 cm high  and were  filled  to  a  volume  of  0.5  liters.   A  stainless  steel

screen separated the chambers to form a 6 cm  x  2.5 cm x  9 cm high sump on one

end.  This  sump  was useful  for  removing  "old"  test solution during  the re-

newal process.

    During the daily renewal process  the  animals  were  first  counted  and any

dead fish  were   removed  and  recorded.  Then waste products  and dead  brine

shrimp nauplii were removed using a siphon tube  similar to the  one described

by Norberg  and Mountl^.  After  the waste  material  and most  of the "old" test

solution was removed to  a  depth of 1  cm, the  animals  were again counted to

assure that none had been accidentally removed  by the siphoning before adding

0.5 liters  of "new"  test  solution.   Dissolved  oxygen  concentrations  were

measured periodically during the  test,  both  on the "old"  and the "new" test

solutions.
                                      10

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    The larval  fish  were fed 3 times per  day at 5 hour intervals during the




simulated daylight period with  0.05-0.1 ml  of concentrated live brine shrimp




nauplii (incubated  24 hours  @  28°  C)  that  had been rinsed  with distilled




water.




     At test termination, surviving  fish were removed, counted, recorded, and




dried to a constant  weight  (20-22  hrs @  60° C).  Final net dry weights for a




composite of the  surviving  fish from each  replicate  chamber  for  each treat-




ment were obtained  utilizing an analytical balance  (with  an  accuracy of .01




mg).  Initial  dry weights  were obtained  at  the start  of the test  on  four




groups of ten  fish « 24 hrs old) by the same method.




    3)  Ceriodaphnia dubia Life Cycle Test




    A life cycle  test  using  Ceriodaphnia  dubia and  the method developed  by




Mount and Norberg^  was conducted  using  Lower  Fox River  and  Lake Winnebago




waters.  One animal  < 10 hours old  was  placed  into each  of the  30  ml glass




beakers filled  with 15  ml  of  test  water.  This  test  water was  warmed  and




aerated in the manner described above and dispensed using a  30  cc  Manostat




pipette.




    The animals were  fed 0.1  ml of YCTF (a suspension of  yeast,  a Cerophyl®




extract, and  a commercially  formulated  trout  food) each  day of the test.




    The test solutions  were renewed on  day 3 and day 5 by filling  cleaned,




rinsed and labeled beakers with 15 ml of the "new" solution plus the food and




then transferring the adult Ceriodaphnia from the "old" to the "new"  solution




with a pipette.




    Survival of the  original  animals and  the  number of young  produced  were




recorded on renewal  days  as well as on day seven.   The  number of young  produced
                                    11

-------
in each brood  was  enumerated;  differentiating broods by  the relative  size




of the offspring.  The measured responses were the number of original animals




surviving beyond the third brood and the  number  of offspring produced in the




first three broods.




B)  Liquid Phase Elutriate




    The techniques developed for evaluating toxicity of dredge samples^ were




employed in an  effort  to  obtain an index  of chemical toxicity  for  contami-




nants solubilized  from the sediments into  the  water column.  These tests may




closely simulate  the  potential hazards encountered  by aquatic  organisms  at




the sediment-water  interface.   Daphnia  magna was  used as  the test  organism




because it is very sensitive to industrial effluents and  wastewater treatment




discharges in the liquid phase^.




     The method  employed  in  preparation  of  the liquid phase  elutriate test




solution consisted  of:  homogenizing the  sediment grab  sample by mechanical




stirring; proportioning sediment to water  at  a 1:4 ratio (by volume); mecha-




nical agitation of the sediment water combination for 1/2 hr; settling of the




larger suspended  solids  for  a minimum  of  16  hrs;  and finally,  removal  of a




majority of all  suspended solids by centrifuging for 45  min. to  1 hr at 2600




rpm.  Reconstituted hard water^ was  used for the dilution water  for the test




conducted during  the  January  1985 period;  river  water  from  the respective




stations was used for dilution water  for the March and April testing periods.




The leachate from this process  was then decanted  from centrifuge bottles and




placed into test chambers; the solids were discarded.




    1)  Daphnia magna Acute Test




    The Daphnia magna  acute  and chronic  tests for the liquid phase elutriate




experiments were  conducted simultaneously  in the same chamber (an acute test
                                    12

-------
was not conducted during the April testing period).  At the start, 10 (5 pr 6




day old) animals were  placed  into each beaker.  No  food  was  added to any of




the containers during  the  acute phase of this  test.   Survivors  were counted




and recorded after 24 and 48 hours.




    2)  Daphnia magna Chronic Test




    In conjunction with the above described acute test and after 48 hours had




elapsed, the animals in each container were reduced to 5.  Food consisting of




1 ing  (oven  dry weight)  commercial trout food  in a  suspension  and  2  x 10'




cells Selanastrum was  added to each  beaker  every 2-3 days after  the second




day.  The chronic test ran for a total of 10 days after which time the number




of surviving  original  test  organisms and the  number of  offspring  produced




were counted and recorded.




C)  Solid Phase




    To allow the test organisms more direct  access to all phases of chemicals




in a  system  (solubilized,  bound to suspended  solids,  and those incorporated




in the sediments) a solid phase bioassay adapted from the method described by




Nebeker et al. -* was utilized.




    Wet sediment was  stored at  4° C  for  not more  than 10 days  before the




solid phase bioassays began.  From a homogenized sample of sediment from each




station, 200 ml  of  sediment was  subsampled  and placed  into each  of 2  or  3




replicate 2 liter battery  jars.   Eight hundred ml of  water  from the respec-




tive station was then gently poured into each battery jar, bringing the total




volume to 1,000 ml.  These systems were left undisturbed  overnight  to allow




the particulate matter to  settle  and  to allow  for  exchange between the water




and sediments.  Before test organisms  were  introduced, aeration was provided




for 1/2 hour  through a glass Pasteur  pipette  with the tip submerged 2-3 cm




below the surface of the water.




                                      13

-------
     The test  started  when the animals  were introduced and  continued  for a




total of 10 days.  Ten 5  or  6 day old Daphnia; 5 adult Hyalella; and for the




March testing  period,  5  larval Ephemerella  were  placed  in  each  of 2  or 3




replicate chambers  for  each treatment.   Stainless  steel  mesh bent  into a U




shape and measuring  6.5  cm  x 6.5  cm was  provided as a  substrate  for the




Ephemerella.  The test chambers were left uncovered and were aerated through-




out the test.   Deionized,  distilled water was used to  replace  losses due to




evaporation.  Food was added to the  systems  every  2 to 3  days in the form of




5 rag  (oven  dry  weight)   commercial  trout  food  in   a suspension  and  10^




Selanastrum cells per chamber.




    The test was terminated after 10 days by first counting and recording the




number of surviving test  organisms  contained in  the overlying water and then




by screening the  sediments (using a sieve  with  500 micron  openings)  to re-




cover the remainder.  The  number  of original test  animals  surviving to test




termination and the total  number  of daphnids  produced  in each  chamber were




recorded.




Statistical Analysis




     All biological effects  data  were analyzed  using  a one-way  analysis  of




variance and a two sided Dunnett's test (p = 0.05).




Quality Assurance




     Sampling sites for this  investigation  were  selected  using  the criteria




outlined in the Description  of Study Area section.  The  collection, identi-




fication,  transportation,   and  storage  of environmental  samples  were  under




the direct   supervision  of the first  author.  The  first  and  second authors




directly supervised all biological  measurements  and procedures  and assigned
                                    14

-------
chemical samples  to  co-authors for analysis.   Statistical  analysis was con-




ducted by the first author.






                                 RESULTS




     Physical and chemical  measurements  of the pH, alkalinity, conductivity,




hardness, chloride,  nitrite,  nitrate, phosphate,  sulfate,  ammonia (total as




NH,  and unionized)  and  sulfide for  all  stations sampled  on Lake Winnebago




and the Lower Fox River  are given in Table 2.  The hydrogen ion activity was




elevated in April  compared to the  sampling times in January  or  March by as




much as a ten-fold  increase.   Alkalinity  and  hardness  values were relatively




constant over the  sampling period.   Conductivity  measurements were consist-




ently higher  at  station A  (mouth of  the  river)  than at  stations upstream.




Chloride concentrations  were  as  great or  greater at the mouth  of the river




when compared  to  stations  upstream.   Nitrite, phosphate  and  sulfide  were




below detection limits of the methods used.  Nitrate concentrations were much




higher at all  Lower Fox River stations  in  March than in  either  January or




April.  For  samples collected  in April  the  sulfate concentrations  and the




total ammonia as  NH,+  were considerably higher at station A  than for other




stations and times tested.




     The values  for the water quality parameters measured during  the  bio-




assays appeared adequate to meet  the  requirements  of the test organisms.''^




The dissolved  oxygen content  of  the  water  the fathead  minnows   (Pimephales




promelas) were  exposed  to  was _>.  5.9 mg/1.   Measurements  of the dissolved




oxygen content of the elutriate water revealed values 2. 8.0 mg/1.   The solid




phase test  systems  were continually  aerated.  The  pH ranged from 7.6-9.3,




alkalinity from 134 to 172  mg/1  as CaC03, and  hardness  from  158  to 199 mg/1




as CaCOg for the Daphnia experiments.







                                      15

-------
Table 2.  Physical and Chemical Data for Water Collected From the Lower Fox River at Various Locations and Dates
                                                         Sampling Station^
Jan. 30-31, 1985
pH
alkal mg/1
cond ps/cm
hardness rag/1
Cl mg/1
N02 mg/1
N03 mg/1
P04 mg/1
S04 mg/1
NH * mg/1 (total)
NHj-N mg/12
sulfides mg/1
March 13-14, 1985
temp °C3
PH
alkal mg/1
cond ps/cm
hardness mg/1
Cl mg/1
N02 mg/1
N03 mg/1
P04 mg/1
S04 mg/1
NH,+ mg/1 (total)
NH3-N mg/12
sulfides mg/1
April 30, 1985
temp °C3
PH
alkal mg/1
cond ps/cm
hardness mg/1
Cl mg/1
N02 mg/1
N03 mg/1
P04 mg/1
S04 mg/1
NH,+ mg/1 (total)
NH3-N mg/12
sulfides mg/1
A
7.96
164.8
397
193.9
18
<0.2
0.9
<0.2
22.7
0.56
0.015
<1.0
3
7.63
133.6
440
164.9
20
<0.05
4.0
<0.15
22.5
1.07
0.014
<1.0
18
8.38
153.7
419
188.1
31.3
<0.05
1.1
<0.10
36.0
1.93
0.102
<1.0
B
7.97
163.8
361
188.0
10
<0.2
1.4
<0.2
19.7
0.24
0.007
<1.0
3
7.80
146.4
380
175.5
16
<0.05
4.0
<0.15
19.0
0.40
0.008
<1.0
17
8.90
141.8
300
159.1
13.4
<0.05
1.1
<0.10
16.0
0.26
0.048
<1.0
C
8.00
163.4
309
187.6
14
<0.2
1.4
<0.2
19.7
0.26
0.008
<1.0
3
7.87
145.7
348
178.0
16
<0.05
4.0
<0.15
19.0
0.44
0.010
<1.0
17
8.75
141.3
315
159.2
13.6
<0.05
1.1
<0.10
16.0
0.24
0.035
<1.0
D
8.05
163.6
318
189.4
14
<0.2
1.4
<0.2
20.2
0.23
0.008
<1.0
3
7.78
132.7
379
166.5
20
<0.05
4.4
<0.15
19.5
0.64
0.012
<1.0
17
8.65
144.8
315
162.7
16.4
<0.05
1.2
<0.10
18.0
0.33
0.039
<1.0
E F G
8.
168.
360
195.
13
<0.
1.
<0.
19.
0.
- 0.
- <1.
3
7.
158.
355
180.
14
- <0.
- 3.
<0.
18.
- 0.
- 0.
<1.
18 19 19
8.95 8.93 8.
138.3 140.4 140.
273 310 285
158.7 159.6 160.
11.4 11.4 11.
<0.05 <0.05 <0.
1.0 0.4 0.
<0.10 <0.10 <0.
15.0 16.0 15.
0.28 0.40 0.
0.057 0.078 0.
<1.0 <1.0 <1.
08
9

1

2
5
2
7
23
008
0

94
5

4

05
8
15
5
24
006
0

98
4

2
6
05
9
10
0
26
055
0
H
8.02
162.9
362
188.4
13
<0.2
1.4
<0.2
18.3
0.16
0.005
<1.0
_
7.94
160.9
412
189.6
13
<0.05
3.5
<0.15
18.5
0.18
0.005
<1.0
-
-
-
-
-
-
-
-
-
-
-
-
I
-
-
-
-
-
-
-
-
-
-
3
7.94
165.8
383
198.9
13
<0.05
3.4
<0.15
17.7
0.13
0.003
<1.0
18
9.01
140.8
300
158.4
11.4
<0.05
0.8
<0.10
15.0
0.30
0.066
<1.0
J
-
-
-
-
-
-
-
-
-
-
3
7.83
166.3
399
194.9
13
<0.05
4.0
<0.15
17.0
0.16
0.003
<1.0
18
9.3
140.4
282
159.6
11.4
<0.05
0.8
<0.10
15.0
0.33
0.115
<1.0
K L
7.99
166.6
328
188.4
13
<0.2
1.3
<0.2
14.8
0.05
0.002
<1.0
3
7.75 7.67
164.0 168.2
415 395
194.9 192.9
17 10
<0.05 <0.05
3.7 3.0
<0.15 <0.15
19.2 14.5
0.28 0.10
0.005 0.002
<1.0 <1.0
18 17
9.06 9.27
148.4 139.0
290 275
162.3 164.2
13.1 9.5
<0.05 <0.05
0.6 0.4
<0.10 <0.10
16.0 13.0
0.28 0.16
0.069 0.051
<1.0 <1.0
M
8.19
172.4
367
197.4
11
<0.2
1.3
<0.2
16.8
0.34
0.015
<1.0
_
7.61
155.3
378
187.4
10
<0.05
0.8
<0.15
13.5
0.05
0.001
<1.0
-
-
-
-
-
-
-
-
-
-
—
-
1 See Figure 1
  Unionized ammonia calculated from total ammonia as NH4* using the table in Appendix A-l
    from Thurston et al. 197916.                            , ,
3 At time of collection                                    J-"

-------
     There was no  significant  adverse  effect  on survival of Daphnia, fathead




minnow, or  Ceriodaphnia exposed  to Lower  Fox River  water over  the entire




testing period and  for  the  various lengths of exposures (Tables 3, 4 and 5).




There was, however, a significant adverse effect on growth of fathead minnows




exposed to  water  from  station  D collected  in January (Table 4),  and  water




collected in  March  significantly  reduced  Ceriodaphnia reproduction  for all




test stations except L.




     The elutriate water was not  toxic to Daphnia in the acute tests  (Table 6).




Survival was  >_ 93%  in the  10 day elutriate tests  with the  exception of sta-




tion K in April  when there  was  total  mortality in 2  of  3  replicates.   Elu-




triate water  from station G  in March and station K in April significantly re-




duced young  production; however,  Daphnia  exposed to  elutriate  water  from




several stations had greater young production than those in reference waters.




     Survival of Daphnia in the  reference units  for  the January  and  March




solid phase  test   was   unsatisfactory  (70%  &  43%,  respectively);  however,




survival was  >^ 80%  for  all   other stations  (Table  7).   There was no signifi-




cant adverse  effect on  survival  of Daphnia in the solid phase test in April.




Survival of Hyalella in the  reference units of the solid phase test was  _>. 80%




and there was no  significant adverse  effect  on survival of Hyalella in the




treatments over the entire  testing  period.  Survival  of  Ephemerella exposed




to the solid phase during the March testing period was  less than satisfactory




(73%) in the  reference  units and, therefore,  no  significance can  be attri-




buted to the response in the treatments.   Reproduction of Daphnia was consis-




tently lower  in  the reference units  of  the  solid phase  tests  than in the




treatments (Table 8).
                                      17

-------
Table 3.  Mean Percent Survival of Daphnia magna Exposed to Lower Fox River
Water For
Stations
A
B
C
D
E
F
G
H
I
J
K
L
M
48 hrs.
January
100
100
100
100
-
-
100
90
-
-
100
-
100+

March
100
100
100
100
-
-
100
100
100
100
100
100
100+

April
100
100
100
100
100
100
100
-
100
100
100
100+
_
+ Reference station
                                    18

-------
Table 4.  Survival and Growth of Pimephales promelas Exposed to Lower Fox

Stations

A
B
C
D
E
F
G
H
I
J
K
L
M
River Water For
Seven
Mean Percent
January
97
83
80
90
-
-
90
97
-
-
87
-
93+
Days.
Survival
March April
93
93
87
98
-
-
90
97
93
90
93
93
97+
90
97
100
87
100
97
97
-
87
93
97
93+
"

Specific
January
22.9
23.0
25.8
20.7*
-
-
23.2
22.9
-
-
23.4
-
26. 6+

Growth Rate
March
28.7
29.9
29.5
28.4
-
-
29.6
28.8
28.3
28.4
27.5
29.6
29. 2+

(%/Day)
April
29.7
30.7
30.6
29.7
30.2
30.5
30.2
-
28.9
30.2
30.4
29. 7+
™
* Significantly less (p = 0.05) than reference station




+ Reference station
                                    19

-------
Table 5.  Survival and Reproduction of Ceriodaphnia dubia Exposed to Lower
Fox River Water.
Stations Mean Percent Survival
A
B
C
D
E
F
G
H
I
J
K
L
M
Jan Mar
90 100
100 100
100 100
80 100
-
-
100 100
90 100
100
100
90 100
100
100+ 100+
Apr
100
100
100
80
100
100
70
-
100
90
80
90+
-
No. of young in 3 broods
per surviving female + SD
Jan Mar
25 _+ 5 22
24 +_ 4 21
21+7 20
24+4 21
-
-
21 _+ 9 21
23+5 22
23
23
22+9 22
28
22 + 6+ 28
_+ 2*
+_ 4*
± 3*
± 3*
-
-
± 3*
+ 2*
_+ 5*
± 3*
+ 2*
_+ 3
+ 3+
Apr
29 +
25 _+
25 _+
26 _+
25 +_
27 _+
27 _+
-
25 +_
27 +
24 _+
26 +_
—
3
2
3
2
3
3
3

4
2
4
2+

* Significantly less (p = 0.05) than reference station




+ Reference station
                                    20

-------
Table 6.  Survival  and  Reproduction of Daphnia magna in Elutriate  Tests.


           Survival in  48 hrs     Survival in 10 days   Young  production/chamber
Stations    (mean percent)          (mean percent)      	(mean + S.D.)	

           Jan   Mar    Apr        Jan   Mar   Apr       Jan      Mar      Apr

                                                        119 +_ 13    43 +_ 6    93 _+ 6

                                                         94 ^ 12    34 _+ 5    78 _+ 8

                                                         95 _+ 14    29 _+ 10  75 JK 5

                                                        125 _+ 16    49 _+ 6    95 4- 18

                                                                             72 ± 5

                                                                             68 _+ 3

                                                        101 +_ 8    21 _+ 3*  81 +_ 8



                                                                    29 +_ 3    55 JK 14

                                                                    24 +_ 4    89 _+ 7

                                                                    24 _+ 4    22 _+ 38*

                                                                    35 jf 5+  74 _+ 7+

                                                         73 _+ 23+



* Significantly less  (p = 0.05)  than reference station

+ Reference station
A
B
C
D
E
F
G
H
I
J
K
L
M
100 100
100 100
100 100
100 100
_
- - -
100 100
_
100
100
100
100+
100+
100 100
93 100
100 100
100 100
-
_
100 100
-
100
100
100
100+
100+
100
100
100
100
100
100
100
-
100
100
33*
100+
-
                                     21

-------
Table 7.  Mean Percent Survival of Daphnia magna,  Hyalella azteca and

Stations

A
B
C
D
E
F
G
H
I
J
K
L
M
Ephemerella sp.
Daphnia
Jan Mar
93 97
97 83
100 100
97 100
-
-
97 87
-
100
100
90
43+
70+
in Solid

Apr
100
100
95
100
100
60
100
-
90
100
100
95+
_
Phase Tests.
Hyalella
Jan Mar
67 80
87 87
100 93
80 100
-
-
87 93
-
67
73
87
80+
90+


Apr
90
100
90
90
80
50
80
-
100
80
100
90+
_

Ephemerella
Mar
47
60
40
67
-
-
73
-
53
87
67
73+
_
+ Reference station
                                    22

-------
Table 8.  Reproduction of Daphnia magna in Solid Phase Tests.
Station










  A




  B




  C




  D




  E




  F




  G




  H




  I




  J




  K




  L




  M







+ Reference station
                                  Daphnia magna reproduction
(number of
January
335 _+ 49
313 _+ 30
326 + 30
315 +_ 5
-
-
317 + 21
-
-
-
_
young/chamber + S.D.)
March
371 +_
325 _+
312 _+
332 _+
-
-
280 +_
377 _+
226 +_
369 _+
93 +

91
73
25
40


80
35
63
53
60+
April
393 + 52
421 + 91
418 +_ 14
291 +_ 10
327 +_ 33
270 +_ 147
405 + 105
382 + 212
223 + 27
482 +_ 146
268 + 1+
197 + 50+
                                    23

-------
                                 SUMMARY




     Physical and  inorganic  chemical measurements  made on  Lower Fox  River




water show few abnormal values.  Unionized ammonia (NI^-N)  levels were higher




in April due to the influence  of  an  increase in pH during  that period on the




relative percentage of unionized to  total  ammonia.   Nitrate  concentrations




were elevated  in  March  compared  to the  January  or  April   study  periods.




Conductivity, ammonia, chloride,  and sulfate  values  all measured higher  at




station A  compared to  the  other  stations.   Dissolved oxygen  measurements




obtained from the WDNR^' for the Lower  Fox  River range from 12.0 - 17.9 mg/1




for January, 12.7 - 18.0  mg/1 for February, 9.9  -  17.4 mg/1 for March, and 7.5




-17.9 mg/1 for April, 1985.




     Results from  the present  study of  Lower  Fox  River  water indicate  a




general absence of lethal effects as  defined by the bioassays used and within




the temporal  and  spatial  framework  of  the   study.   Significant  sublethal




effects resulting  from exposure to  Lower Fox  River  water  included  reduced




growth of  fathead  minnows  for  station  D in  January  and  fewer  Ceriodaphnia




progeny for stations A-K in March.




     The liquid  phase elutriate  test  showed   few  lethal   effects  with  the




exception of total mortality of Daphnia magna  in  two  of three  replicates for




station K in April; the third had 100% survival.  Production of young Daphnia




varied greatly in  the elutriate  test  with two stations (G in  March  and K in




April) producing significantly fewer  young than the reference station (L) and




three stations (A  and D in  January  and D in  March)  producing significantly




more young than the reference station.




     Survival and  reproduction of Daphnia magna in the  solid  phase  test was




often less for the reference stations than for the other stations.  The solid
                                      24

-------
phase was  not  toxic to Hyalella in  the  10 day tests.  Ephemerella  were not




well suited for the static environment of the solid phase test.






                                  DISCUSSION




     Laboratory bioassays using Lower Fox  River  water and sediment  failed to




reveal consistent lethal effects.  A pathogen may have been the cause for the




total mortality of  Daphnia observed  in two  of three replicates for Station K




in the  elutriate  tests in April.  The  observed presence of  indigenous  zoo-




plankton (Crustacea) in  water collected for  these  experiments further subs-




tantiates the lack  of  mortality  recorded in the  bioassays.   Consequently, an




analysis of  contaminants  in  Lower   Fox  River  water  was  not  undertaken.




     No pattern was evident   for the  sublethal effects observed  and the ef-




fects were  not  observed for  more  than  one species  or  testing period.   The




cause-effeet relationship  for  the  significantly  fewer  Ceriodaphnia  pro-




duced in March  is not  known.   In  the elutriate tests,  nutrients present in




the water  and  those  released from  the  sediment  may  have  been  more  of  a




causative agent for the variability observed in young production than a toxic




influence.




     Cairns et al.^° reported acute toxicity to Daphnia magna exposed  to liquid




phase elutriate from two  stations  on the  Lower  Fox River (mouth  and  0.8  km




upstream) collected  in  1982.   Their  measurements   of  suspected  toxicants




showed all were below  the  acutely  toxic  level.  A  second testing yielded no




significant mortality.




     A previous investigation by personnel  of ERL-D^ also indicated  no toxi-




city to  fathead  minnows  (Pimephales promelas)  or  Ceriodaphnia   in ambient




tests conducted in  1983.   The investigators  did,   however,   record adverse
                                      25

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effects with dilution  or  receiving water  used in conjunction  with effluent




toxicity testing.   In  a  personal  communication,  D.  McCauley^  reported  a




lethal effect on  fathead  minnows  (Pimephales promelas)  under test  conditions




similar to the ones described herein with water collected near the DePere Dam




(in the vicinity  of  Station  G)  in April, 1984.  Toxicity events in the Lower




Fox River appear to be episodic  in nature.




     Several limitations of the  present investigation's ability to accurately




assess potential  instream toxicity  are  evident.  The  limitations  of  a  grab




sample at particular points  in time are  inherent.  The process(es) occurring




during prolonged storage  and the resulting effects on  the  integrity  of water




samples are not well defined.   It  is  likely that aeration used to stabilize




dissolved gases for the bioassays may  have  altered the environmental samples




and their potential  toxicity.   Also,  the  influence  of laboratory  bioassay




temperature conditions on potential toxicity is  open to  discussion.   In  situ




bioassays and instream measurements could  more accurately evaluate potential




instream toxicity in an environment such as the Lower Fox River.
                                REFERENCES




1.  Markert,  B.E.   1981.  Water  Quality  Improvements  in  the Lower  Fox River,




    Wisconsin, 1970-1980:  An Historical  Perspective.   IPC  Technical  Paper




    Series, Number  105.  Institute  of Paper Chemistry,  Appleton,  Wisconsin.




    9 p.




2.  Wisconsin  Department   of Natural Resources.   1978.   Investigation  of




    Chlorinated and Nonchlorinated  Compounds  in  the  Lower Fox  River Water-




    shed.  EPA-905/3-78-004.  U.S. Environmental  Protection Agency,  Chicago,




    IL.  229 p.




                                      26

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 3.  Sullivan, J.R. and J.J. Delfino.   1982.  A  Select  Inventory  of Chemicals




     Used in Wisconsin's  Lower  Fox River Basin.  University  of Wisconsin Sea




     Grant Institute,  Madison,  WI.   176 p.




 4.  Anon.  1985.  The Toxicity of Some Industrial Effluents and Their Effects




     Upon Fox  River  Water  Quality.   Unpublished  report,  U.S. EPA,  Environ-




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 5.  U.S. Environmental Protection Agency.  1979.  Methods for Chemical Analy-




     sis of Water and  Wastes.  EPA-600/4-79-020.   Environmental Monitoring and




     Support Laboratory, Cincinnati,  OH.  460 p.




 6.  Beckman  Instruments,  Inc.   Model  0260 Oxygen Analyzer,  015-555375-A.




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 7.  O'Dell, J.W., J.D.  Pfaff,  M.E.  Gales,  and  G.D.  McKee.   1984.  The Deter-




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 9.  U.S. EPA.   Interim Procedures for  Conducting the  Daphnia  magna  Toxicity




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10.  Norberg, T.J., and D.I. Mount.   1985.   A New Fathead  Minnow (Pimephales




     promelas) Subchronic  Toxicity Test.  Environ. Toxicol.  Chem.  4:  711-718.




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     Engineer Waterways Experiment  Station,  Vicksburg,  MS.




                                       27

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13.   Buikema, A.L. , Jr.,  J.G.  Geiger, and D.R.  Lee.   1980.   Daphnia Toxicity

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14.   American Public Health Association/American Water Works Association/Water

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16.   Thurston,  R.V.,   R.C.  Russo,  and  K.  Emerson.   1979.   Aqueous Ammonia

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17.   State  of  Wisconsin.   1985.   Unpublished  Data.  Wisconsin Department  of

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18.   Cairns, M.A.,  A.V.  Nebeker,  J.H.  Gakstatter, and  D.F.  Krawczyk.  Manu-

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19.   McCauley,  D.   1984.   Personal  Communication.   Center  for  Lake  Supe-

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