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RGENCY RESPONSE, WASHINGTON, DC.
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M ANDHAAS CO. 1977. MRID NO 00129980. (CITED IN US EPA, 1987)
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APPENDIX A: TECHNICAL INFORMATION
I. DATA SOURCES AND SELECTION CRITERIA USED IN HEAST
II. DOSE CONVERSIONS ON HEAST
III. CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY
NUMBER CROSS REFERENCE
IV. EFFECT LEVEL DEFINITIONS
V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
-------
APPENDIX A-l
I. DATA SOURCES AND SELECTION CRITERIA USED IN HEAST
A. Description of Sources and Documents Cited in HEAST
1. The Integrated Risk Information System (IRIS):
IRIS is an on-line data base developed by the EPA for compilation of risk
assessment and regulatory information on chemicals and physical agents. IRIS is the
primary communications mechanism for distribution of health hazard assessment
information derived by the various intra-Agency Work Groups. The primary intent of
IRIS is to provide guidance to EPA personnel in making risk management decisions.
An IRIS chemical file contains a Work Group verified summary of the available
information on hazard and dose-response assessment for noncarcinogenic and/or
carcinogenic effects for that chemical and is not an extensive toxicologic data base.
Risk assessment values placed on IRIS are considered Agency consensus and take
precedence over differing risk assessment values from other EPA sources. Each file
includes referenced citations and EPA contacts for obtaining further information on any
specific chemical or agent. The IRIS database was made available to State and local
governments, as well as to the public, in April 1988.
'Questions concerning IRIS: Call IRIS USER SUPPORT at (513)569-7254
2. EPA Work Groups:
Risk assessment values for chemicals currently being considered by EPA Work
Groups, but not yet on IRIS, are included in HEAST. The EPA Reference
Dose/Reference Concentration (RfD/RfC) Work Group and the Carcinogen Risk
Assessment Verification Endeavor (CRAVE) Work Group validates Agency systemic
toxicity and carcinogen risk assessments, respectively. These Work Groups are also
responsible for resolving any conflicts regarding toxicity values developed by various
Program Offices. Work Group members represent many different EPA offices and are
scientists experienced in issues related to both the qualitative and quantitative risk
assessment of carcinogenic and toxic agents. Values verified by these Work Groups
have undergone extensive peer review and represent an Agency consensus. Verified
risk assessment values are entered into the IRIS data base monthly.
*Questions concerning RfD/RfC Work Group: Call Mike Dourson (ECAO-Cincinnati) at
(513)569-7533 or Annie Jarabek (ECAO-Research Triangle Park) at (919)541-4847
*Questions concerning CRAVE Work Group: Call Rita Schoeny (ECAO-Cincinnati) at
(513)569-7544
A-1
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3. Office of Research and Development (ORD)/Office of Health and
Environmental Assessment (OHEA) OSWER-OAQPS (Office of Solid Waste
and Emergency Response-Office of Air Quality Planning and Standards)
Documents:
A listing of most ORD/OHEA OSWER-OAQPS documents can be found in the
Chemical Assessments and Related Activities (CARA) list (available through NTIS)
and/or in the CERI (Center for Environmental Research Information) Office of
Research and Development publications list. The CARA is produced by the Office of
Health and Environmental Assessment (OHEA). All OSWER-OAQPS documents are
subject to a minimum of internal EPA peer review or a maximum of EPA/Peer Review
Workshop/Science Advisory Board and public comments prior to finalization.
*lnformation on the availability of OSWER-OAQPS documents can be obtained from
the following sources:
All Documents:
Technical Information Staff
Office of Health and Environmental Assessment (RD-689)
U.S. Environmental Protection Agency
401 M Street, S.W.
Washington, DC 20460
(202)260-7345
Published Documents:
Center for Environmental Research Information (CERI)
Office of Research and Development
U.S. Environmental Protection Agency
26 W. Martin Luther King Drive
Cincinnati, OH 45268
(513)569-7562
Documents Available Through RCRA/Superfund:
Hotline Number 1-800-424-9346
Documents Available from NTIS:
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
(703) 487-4650
A-2
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Health Effects Assessments (HEAs): This document series was prepared by the
Environmental Criteria and Assessment Office (ECAO-Cincinnati) for the Office of
Emergency and Remedial Response (Superfund). HEAs are intended for use by the
OERR in evaluating risk for its preliminary assessment process at uncontrolled sites,
and for appraising clean-up alternatives in its remedial investigation/feasibility studies.
HEAs are brief, quantitatively oriented, preliminary assessment of relevant health
effects data. HEAs are subject to internal EPA review by staff within the Office of
Health and Environmental Assessment. Final drafts of HEAs become part of the
RCRA and Superfund dockets and are available through NTIS. This series has
recently been incorporated into the following HEED series.
Health and Environmental Effects Documents (HEEDs): This document series is
prepared by the Environmental Criteria and Assessment Office (ECAO-Cincinnati) for
the Office of Solid Waste and Emergency Response (OSWER). HEEDs are intended
to support listings under
the Resource Conservation and Recovery Act (RCRA) as well as to provide health-
related limits and goals for emergency and remedial actions under the Comprehensive
Environmental Response, Compensation and Liability Act (CERCLA). Within a HEED,
both published literature and information within Agency Program Offices are evaluated
as they pertain to potential human health, aquatic life and environmental effects of
hazardous waste constituents. Quantitative estimates, including reference doses for
chronic and subchronic duration for both inhalation and oral exposures, carcinogenic
potency factors, unit risk estimates for air and drinking water, and reportable quantities
(RQs) based on chronic toxicity and carcinogenicity are determined when sufficient
data are available. HEEDs are subject to internal EPA review by staff within the
Office of Health and Environmental Assessment and the Office of Pesticides and Toxic
Substances. Final drafts of HEEDs become part of the RCRA and Superfund public
dockets and are available through NTIS.
Health and Environmental Effects Profiles (HEEPs): This document series was
prepared by the Environmental Criteria and Assessment Office (ECAO-Cincinnati) for
the Office of Solid Waste and Emergency Response (OSWER). HEEPs have been
superseded by HEEDs since mid-FY87. HEEPs are intended to support listings of
hazardous constituents of a wide range of waste streams under Section 3001 of the
Resource Conservation and Recovery Act (RCRA), as well as to provide health-related
limits for emergency actions under Section 010 of the Comprehensive Environmental
Response, Compensation and Liability Act (CERCLA). HEEPs are summaries of the
literature concerning health hazards associated with environmental exposures to
chemicals or compounds and are very similar to HEEDs as described above. HEEPs
were subject to internal EPA review by staff within the Office of Health and
Environmental Assessment. HEEPS are part of the RCRA and CERCLA public
dockets. Final drafts are available through NTIS.
Air Quality Criteria Documents (AQCDs): This document series is prepared by the
Environmental Criteria and Assessment Office (ECAO-Research Triangle Park) for the
Office of Air and Radiation (OAR). AQCDs are intended to support National Ambient
Air Quality Standards (NAAQS) set under Sections 108-110 of the Clean Air Act.
A-3
-------
These documents are evaluations of the available scientific literature on the potential
health effects of air pollutants. AQCDs are subject to internal EPA review by staff
within the Office of Health and Environmental Assessment and the Office of Air and
Radiation. Further review is conducted by the Science Advisory Board/Clean Air
Scientific Advisory Committee, and then, these documents are subject to peer review
workshops and public comments. The AQCDs are mandated by the Clean Air Act
and are revised at 5-year intervals. AQCDs become part of the OAR public docket
and final drafts are available through NTIS.
Health Assessment Documents (HADs): This document series is prepared by the
Environmental Criteria and Assessment Office (ECAO-Research Triangle Park and
ECAO-Cincinnati) for the Office of Air and Radiation (OAR). HADs are intended for
use by the Office of Air Quality Planning and Standards (OAQPS) to determine
possible listing of hazardous air pollutants (HAP) under sections 111 and 112 of the
Clean Air Act. These documents are evaluations of the available scientific literature
on the potential health effects of air pollutants and serve as the scientific data base for
establishing relationships between exposure concentrations and potential health risks.
HADs are subject to internal EPA review by staff within the Office of Health and
Environmental Assessment and the Office of Air and Radiation. Further review is
conducted by the Science Advisory Board/Clean Air Scientific Advisory Committee,
and then, these documents are subject to peer review workshops and public
comments. HADs become part of the OAR public docket and final drafts are available
through NTIS.
4. Miscellaneous Documents:
Drinking Water Criteria Documents (DWCDs): The Environmental Criteria and
Assessment Office (ECAO-Cin) prepares a portion of this document series for the
Office of Water (OW). DWCDs are intended to assist the OW in deriving criteria
standards for chemicals in drinking water, as required under Section 412(b)(3)(A) of
the Safe Drinking Water Act, as amended in 1986. The DWCDs are comprehensive
evaluations of potential health effects, including mechanisms of toxicity, with specific
emphasis on data providing dose-response information. DWCDs contain Health
Advisories (HAs) for 1-day, 10-day and longer-term exposures and drinking water
equivalent levels for lifetime exposures. DWCDs are subject to internal EPA review by
staff within the Office of Health and Environmental Assessment and the Office of
Water. Selected documents are reviewed by the Science Advisory Board and are
subject to peer review workshops and public comments. DWCDs become part of the
Safe Drinking Water (SOW) public docket and final drafts are available through NTIS.
B. Selection Criteria and Sources of HEAST Values
Chemicals with derived noncarcinogenic and/or carcinogen risk assessment values
that have had some level of peer review (i.e., those in peer reviewed EPA documents
or under review by EPA Work Groups) are included in HEAST; this does not include
many interim values (values not found in final EPA documents or not being considered
A-4
-------
by Work Groups) derived for various purposes within Superfund and other Program
Offices. In updating the HEAST, the first source that is checked is the Integrated Risk
Information System (IRIS) for revised or newly added risk assessment values.
Secondly, the status of chemicals under discussion by the R*D/RfC and CRAVE Work
Groups is reviewed. The Office of Health and Environmental Assessment's Chemical
Assessments and Related Activities (CARA) list is also reviewed for new Office of
Water, Office of Air Quality Planning and Standards, and Office of Solid Waste and
Emergency Response risk assessment documents (HEEDs, HEEPs, HEAs, HADs,
AQCDs, DWCDs).
The HEAST also contains chemicals commonly found at RCR/4 (Resource
Conservation and Recovery Act) sites as identified by the Office of Solid \ .aste's
Technical Assessment Branch. Questions about RCRA chemicals may be addressed
by calling the Health Assessment Section (Office of Solid Waste) at (202)260-4761.
Finally, the Office of Radiation Programs provides data on radionuclides for Tables 4A
and 4B of the HEAST. Radionuclides included are those thought to be most
commonly encountered at Superfund sites. Questions concerning radionuclide
carcinogenicity should first be addressed by contacting the appropriate Regional
Radiation Program Manager. A listing of these managers and several contacts in the
Office of Radiation Programs can be found in Exhibit 2 of the User's Guide -
Radionuclide Carcinogenicity.
A-5
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APPENDIX A-ll
II. DOSE CONVERSIONS ON HEAST
In January 1991, the decision was made to replace inhalation Reference Doses
(RfDi) for noncancer toxicity and inhalation slope factors for carcinogenicity, previously
available on the IRIS data base, with Reference Concentrations (RfC) and inhalation
unit risks, respectively. RfCs and unit risks are expressed in terms of concentration in
air (mg/m3), not in terms of "dose" (mg/kg-day) like the RfDs and the oral and
inhalation slope factors. This presents a problem for the Superfund program, since
the current Hazard Ranking System (MRS) and the Risk Assessment Guidance for
Superfund (RAGS): Human Health Evaluation Manual, Parts A and B were developed
using chronic daily intakes and health criteria expressed in units of mg/kg-day.
The decision to replace inhalation slope factors and RfDi values expressed in
mg/kg-day with unit risk and RfC values expressed in mg/m3 was based on two major
factors: 1) the workgroups felt that it was technically more accurate to base toxicity
values directly on measured air concentrations instead of making the metabolic,
pharmacokinetic and/or surface area adjustments required to estimate an "internal
dose"; and 2) there are compounds that elicit route-of-entry effects (e.g., sensitizers
and irritants) where the toxic effect is to the respiratory system or exchange boundary
where a measure of "internal dose" might inappropriately imply effects to other organ
systems or effects from other exposure routes.
Superfund recognizes the importance of these issues and is actively working
with EPA's Office of Research and Development to evaluate the impact of these
changes on its program regulations and guidance. In the short term, however,
modification of program regulations and guidance is not a viable option. Therefore,
the chairs of the RfD/RfC and CRAVE Work Groups were consulted regarding
Superfund's need to make the conversion from a concentration in air to dose. There
was agreement that, in many cases, converting the air concentration data to a dose
(in mg/kg-day) may not add significant uncertainty to the Superfund risk assessment
process, and therefore may be a reasonable use of the data given appropriate
circumstances and Superfund program objectives. These Work Groups will continue
to work with the Superfund program to identify specific instances where it is not
appropriate to make the conversion from unit risk/RfC to inhalation slope factor/RfD
due to the large uncertainty introduced by the assumptions used in the conversion.
Generally, the Superfund Health Risk Technical Support Center will be
responsible for making all appropriate conversions and the values will be identified
with appropriate highlights or footnotes in the Health Effects Assessment Summary
Tables (HEAST). Therefore, HEAST users are strongly advised against making such
conversions themselves. However, it is a critical responsibility of the risk assessor to
consult the original reports cited in the HEAST and to appropriately characterize or
caveat the resulting risk estimates derived from these values so that managers are
fully informed of their origin and related uncertainties.
A-7
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APPENDIX A-lll
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE
REGISTRY NUMBER CROSS REFERENCE
This section lists chemicals and their respective Chemical Abstracts Service
Registry Number (CASRN) for cross referencing on the HEAST. Table A-lll-1 is listed
in numerical order by the CASRN and Table A-lll-2 is listed in alphabetical order by
the chemical name.
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A-19
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APPENDIX A-IV
IV. EFFECT LEVEL DEFINITIONS
Adverse effect. A biochemical change, functional impairment, or pathologic lesion that
either singly or in combination adversely affects the performance of the whole
organism, or reduces an organism's ability to respond to an additional environmental
challenge.
Frank-effect-level (FEU. The exposure level at which there are statistically or
biologically significant increases in frequency or severity of severe effects between the
exposed population and its approriate control group. These severe effects produce an
unmistakable adverse health effect (such as severe convulsions or death).
Lowest-observed-adverse-effect level (LOAEL). The lowest exposure level at which
there are statistically or biologically significant increases in frequency or severity of
adverse effects between the exposed population and its appropriate control group.
Lowest-observed-effect level (LOEL). The lowest exposure level at which there are
statistically or biologically significant increases in frequency or severity of any effects
between the exposed population and its appropriate control group. The effects that
are seen at this level may or may not be considered as adverse.
No-observed-adverse-effect level (NOAEL). An exposure level at which there are no
statistically or biologically significant increases in the frequency or severity of adverse
effects between the exposed population and its appropriate control; some effects may
be produced at this level, but they are not considered to be adverse.
No-observed-effect level (NOEL). An exposure level at which there are no statistically
or biologically significant increases in the frequency or severity of any effect between
the exposed population and its appropriate control.
Adapted from: U.S. EPA. 1991. Integrated Risk Information System (IRIS). Online.
Office of Health and Environmental Assessment, Environmental Criteria and
Assessment Office, Cincinnati, OH.
A-21
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APPENDIX A-V
V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
The Clean Air Act requires that National Ambient Air Quality Standards
(NAAQS) be set and ultimately met for any air pollutant which, if present in air, may
reasonably be anticipated to endanger public health or welfare and whose presence in
the air results from numerous or diverse mobile and/or stationary sources. Since the
primary NAAQS and the inhalation RfC serve essentially the same function, and the
primary NAAQS have extensive data bases rigorously reviewed, the primary NAAQS
with annual averaging times should be used in lieu of an inhalation RfC. Primary
standards are designed to protect public health and secondary standards are designed
to protect public welfare. Each primary NAAQS has either one or two averaging times
depending on the health effects of the chemical. To date, six NAAQS have been
established: Carbon monoxide (CO), Lead (Pb), Nitrogen dioxide (NO2), Paniculate
matter, less than 10 urn in size, (PM10), Ozone (O3) and Sulfur dioxide (SO2). A table
of the most recent NAAQS is provided as Table A-V-1.
The process of establishing and revising the NAAQS is detailed by Padgett and
Richmond (Journal of the Air Pollution Control Association, 33:13-16, 1983). The
primary NAAQS are solely health based and designed to protect the most sensitive
group of individuals (but not necessarily the most sensitive members of that group)
against adverse health effects. Thus, by definition, the NAAQS primary standards
define allowable pollutant concentrations which can be present in the atmosphere
without causing adverse effects, and essentially serve the same function as an
inhalation RfC in a risk assessment/risk management decision. The data bases
supporting each of the NAAQS are extensive. More importantly, the NAAQS are set
by the USEPA Administrator as mandated by Congress after numerous reviews and a
public comment process.
U S. GOVERNMENT PRINTING OFFICE 1993-3 41 -9 3 2 / 8 2 6 9 0
A-23
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TABLE A-V-1
NATIONAL AMBIENT AIR QUALITY STANDARDS3
(as of December 2, 1991)
Pollutant
Carbon monoxide (CO)
Lead (Pb)
(and Lead compounds)
Nitrogen dioxide (NO2)
(Nitrogen oxide)
(Nitric oxide)
Particulate matter
(PM10)
Ozone (O3)
Sulfur dioxide (SO2)
(Sulfur oxide)
Primary Standards'5
9 ppm (10 mg/m3)
35 ppm (40 mg/m3)
1 .5 ug/m3
0.053 ppm
(100ug/m3)
50 ng/m3
1 50 |ig/m3
0.12 ppm
(235 ng/m3)
0.03 ppm
(80 ng/m3)
0.14 ppm
(365 u,g/m3)
—
Averaging
Time
8 hours0
1 hour0
Quarterly
Annual
Annuald
24 hours6
1 hour'
Annual
24 hours0
3 hours0
Secondary
Standards"
None
Same as primary
Same as primary
Same as primary
Same as primary
—
—
0.5 ppm
(1300^ig/m3)
aSource: U.S. EPA. 1991. Subchapter C - Air Programs. Part 50 - National Primary
and Secondary Ambient Air Quality Standards. Code of Federal Regulations
50: 693-697. Revised 7/1/91.
"Primary standards are designed to protect public health; Secondary standards are
designed to protect public welfare.
°Not to be exceeded more than once per year.
dThe standard is attained when the expected annual arithmetic mean concentration
is less than or equal to 50 u,g/m3.
The standard is attained when the expected number of days per calendar year with a
24-hour average concentration above 150 u,g/m3 is equal to or less than 1.
'The standard is attained when the expected number of days per calendar year with
maximum hourly average concentrations above 0.12 ppm is equal to or less than 1.
A-24
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United States
Environmental Protection
Agency
OSWER (5204-G)
ORD (RD-689)
OERR 9200.6-3-3 (93-1)
NTISNO. PB93-92119
EPA 540-R-93-058 *
July 1993
Superfund
SEPA
Health Effects Assessment Summary
Tables
Supplement No. 1 to the
March 1993 Annual Update
-------
9200.6-303(93-1)
EPA 540-R-93-058
PB93-921199
July 1993
HEALTH EFFECTS ASSESSMENT
SUMMARY TABLES
FY-1993 Supplement No. 1
U S Environmental Protection Agency
Region 5. Library
77 West Jackson Boulevard, iZtn Floor
Chicago, It 60604-3590
Office of Research and Development
Office of Emergency and Remedial Response
U.S. Environmental Protection Agency
Washington, DC 20460
-------
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DISCLAIMER
This report has been prepared by the U.S. Environmental
Protection Agency. The information contained herein has been taken
from final documents prepared by the Office of Health and Environ-
mental Assessment for the Office of Solid Waste and Emergency
Response and the Office of Water, Washington, DC and the Office of
Air Quality Planning and Standards, Research Triangle Park, NC.
These documents were reviewed in accordance with Agency policy and
approved for publication. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
11
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TABLE OF CONTENTS
Page
INTRODUCTION 1
WHAT'S NEW IN THE JULY 1993 SUPPLEMENT NO. 1 9
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) 1-1
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) 2-1
HEAST TABLE 3: CARCINOGENICITY 3-1
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY) Rl-1
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -
SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) R2-1
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY R3-1
111
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INTRODUCTION
This document is the July 1993 Supplement No. 1 for the March
1993 Annual Update of the Health Effects Assessment Summary Tables
(HEAST) prepared by EPA's Office of Health and Environmental
Assessment, Environmental Criteria and Assessment Office,
Cincinnati, OH for use at both Superfund and RCRA sites. It
updates the information in the March 1993 HEAST and should be
checked whenever that document is consulted. This supplement was
not produced to stand alone and does not contain the User's Guides
or Appendix that are available in the annual update. Thus, the
user is strongly encouraged to reference the March 1993 HEAST for
this information. Supplement No. 2 for the March 1993 HEAST is
planned for release in November 1993.
The HEAST is a comprehensive listing consisting almost
entirely of PROVISIONAL HEALTH EFFECTS INFORMATION relative to oral
and inhalation routes for chemicals of interest to Superfund, the
Resource Conservation and Recovery Act (RCRA) , and the EPA in
general. These entries in the HEAST are limited to chemicals that
have undergone review and have the concurrence of individual Agency
Program 'Offices, and each is supported by an Agency reference.
This health effects information has not, however, had enough review
to be recognized as high quality, Agency-wide consensus
information.
The Integrated Risk Information System (IRIS) is the Agency's
official repository of Agency-wide consensus chronic human health
risk information. IRIS evaluations are conducted by the Agency's
Work Group Review process, i.e., they have been examined by either
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the Reference Dose/Reference Concentration (RfD/RfC) Work Group or
the Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work
Group. These Agency Work Groups conduct a process that leads to
internal Agency scientific consensus regarding health effects
information on a chemical. This information is recorded on IRIS,
is considered to be "Work Group Verified", and does not appear on
the HEAST. Thus, provisional health effects information on the
HEAST is subject to possible review and revision by these Agency
Work Groups.
There are two exceptions to the above discussion. The HEAST
also contains information on chemicals that are a part of the
National Ambient Air Quality Standards (NAAQS) or the Drinking
Water Criteria Document (DWCD) series. In each of these cases, the
chemicals are subject to extensive scientific peer review processes
of extremely high quality.
CHEMICAL STATUS DEFINITIONS
Chemicals reviewed by the Agency Work Groups are classified
according to their status as either "verified", "not verifiable",
or "under review". The toxicity values (other than NAAQS or DWCD
values) listed on the HEAST are considered to be "provisional."
The Agency has no official definitions for these terms, but the
HEAST user may interpret them as follows:
Provisional: A toxicity value or a cancer value is
"provisional" if the value has had some form of Agency
review, but it does not appear on the IRIS system. These
values are generated in several ways. Often they are
determined in the course of developing an Agency document
on a chemical or on a class of chemicals. Some have been
generated through the Work Group process, but have not
yet been input to the IRIS system. At the time each
_2 _
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value was derived, all available information on the
chemical was evaluated, the value was calculated using
the most current methodology, and a consensus was reached
on the value by Agency scientists.
Brackets are placed around the names of toxicity and
carcinogenicity values on the HEAST to distinguish these
"provisional" values from information on IRIS. The
following names are affected: RfD to [RfD] , RfC to
[RfC], slope factor to [slope factor], EPA group to [EPA
Group] and unit risk to [unit risk].
These "provisional" values are found on the HEAST. They
do not appear on IRIS.
Verified: A toxicity value or a cancer value is "Work
Group Verified" if all available information on the value
has been examined by an Agency Work Group, the value has
been calculated using current Work Group methodology, a
unanimous consensus has been reached on the value by the
Work Group, and the value appears on IRIS.
Some numbers that have achieved unanimous consensus by
the Work Group may appear on the HEAST for a short time
until they are loaded onto IRIS, at which time they are
termed, "verified." During the interim, they are
considered to be "provisional" values that are still
"under review" by the Work Group.
These "verified" numbers only appear on IRIS. They do
not appear on the HEAST.
Not verifiable: A toxicity value is "not verifiable" if
an Agency Work Group has considered all available data on
a chemical and has unanimously determined that data are
inadequate to generate a value that would be suitable for
inclusion on IRIS. No toxicity value is calculated; no
toxicity value is available for IRIS or the HEAST.
This "not verifiable" status is noted on IRIS, and is
sometimes found on the HEAST, with a pointer to the IRIS
system.
Under Review: A toxicity value is "under review" if an
Agency Work Group is in the process of considering all
available data on a chemical. All Work Group chemicals
will have this status until the toxicity value is placed
on the IRIS system. Toxicity values that have been
withdrawn from IRIS by a Work Group for further review
will have this status.
This "under review" status may be indicated on IRIS or on
the HEAST. During this time, "provisional" toxicity
values may appear on the HEAST.
o _
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In all cases, the status of a chemical may change as new data
become available, and the assessment is revisited.
CAUTION
It is imperative for each user of the HEAST to recognize that
the values listed in the toxicity tables and the cancer table are
generally considered to be PROVISIONAL HEALTH EFFECTS INFORMATION.
The user is referred to IRIS for "Work Group Verified" values. It
is also important to remember that the numbers in these tables
alone tell very little about the adverse effects of a chemical or
the quality of evidence on which health effects information is
based. Original assessment documents must be consulted by users of
the HEAST in order to fully appreciate the strengths and limita-
tions of a specific data base. Original source documents will
allow for the most complete characterization of potential toxicity
associated with the range of exposure pathways generally evaluated
at Superfund and RCRA sites. The Reference Tables point the user
to these sources.
CONTRIBUTORS
Chemicals commonly found at RCRA sites as identified by the
Office of Solid Waste's (OSW) Technical Assessment Branch are
included in the HEAST. The Office of Radiation Programs has
provided data on radionuclide carcinogenicity for Tables 4A and 4B
of the HEAST. Finally, the Office of Air Quality Planning and
Standards (OAQPS) has provided information on chemicals for which
Air Quality Criteria Documents and National Ambient Air Quality
Standards have been developed.
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CHEMICALS LISTED
Most of the chemicals included on the toxicity tables and
carcinogenicity table are those for which at least one of the
following EPA documents has been written: Health Effects Assess-
ment Document (HEA), Health and Environmental Effects Profile
(KEEP), Health and Environmental Effects Document (HEED), Health
Assessment Document (HAD), Air Quality Criteria Document (AQCD),
Drinking Water Criteria Document (DWCD). A description of each is
provided in Appendix A, Section I. In a few cases, the values are
supported by other written material, such as Work Group meeting
notes or Carcinogen Assessment Group (CAG) Profiles. Radionuclide
slope factor values are calculated by the EPA's Office of Radiation
Programs.
The names of criteria pollutants that are regulated as
National Ambient Air Quality Standards (NAAQS) under the Clean Air
Act are listed in the main body of the HEAST, but the actual
criteria are included as Section V of Appendix A: Technical
Information. The NAAQS were not included in the tables in order to
distinguish them from the reference concentration ([RfC]) values.
The NAAQS and [RfC]s represent different levels of review and
different methods of calculation and thus, must be interpreted and
used differently.
HIERARCHY OF SOURCES
It is recognized that at any point in time there may be
multiple old and new Agency documents or data bases that present
different values on a specific chemical. For chemicals other than
those represented by the NAAQS or DWCDs, the following hierarchy of
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sources is recommended in evaluating chemical toxicity for
Superfund sites:
1. The Agency's Integrated Risk Information System
(IRIS) and cited references. Changes are made in
this data base on a monthly basis, but there may be
data gaps. Call IRIS USER SUPPORT at (513)569-7254
for further information.
2. The Health Effects Assessment Summary Tables (HEAST)
and cited references.
3. Consultation with the Superfund Health Risk Tech-
nical Support Center (TSC) at (513)569-7300.
4. Do not consult either the toxicity tables (Appendix
A) in the Superfund Public Health Evaluation Manual
(SPHEM, U.S. EPA, 1986) or the September 1988 Public
Health Risk Evaluation Data Base (PHRED) as these
sources are likely to contain numerous values that
have since become out-of-date.
QUESTIONS
Chemical Toxicity and Carcinogenicity
Regional EPA Superfund Staff may direct questions regarding
the contents of the chemical toxicity and carcinogenicity tables on
the HEAST (e.g., chemicals not covered, chemicals with pending
[RfD]s) to EPA's Superfund Health Risk Technical Support Center
(TSC) in Cincinnati, OH at (513)569-7300. Questions from other
users must be submitted to the TSC in writing and must contain the
following information:
• Superfund site name, site location and twelve-digit
site number;
• Name and phone number of the site Remedial Project
Manager (RPM) or Regional Risk Assessor/Toxicologist;
• Detailed description of the health effects information
related question.
-6-
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Please send requests via mail or FAX to:
Superfund Health Risk Technical Support Center
US EPA
26 W. ML King Dr.
Environmental Criteria and Assessment Office
MS 117
Cincinnati, OH 45268
FAX#: (513)569-7159
RCRA Chemicals
Questions about RCRA chemicals may be addressed by calling the
Office of Solid Waste at (202)260-4761.
Radionuclide Carcinogenicity
Questions concerning radionuclide carcinogenicity should first
be addressed by contacting the appropriate Regional Radiation
Program Manager. A listing of these managers and several contacts
in the Office of Radiation Programs can be found in Exhibit 2 of
the User's Guide — Radionuclide Carcinogenicity.
REFERENCES
Most cited Agency references (e.g., HEAs, HEEPs, HEEDs), are
(or will soon be) available through the National Technical
Information Service (NTIS), 5285 Port Royal Road, Springfield, VA
22161 [(703)487-4650]. Carcinogen Assessment Group (CAG) Profiles
cited in Table 3 are available through the RCRA docket
(202)260-9327.
ORDERING INFORMATION
Limited copies of the HEAST are available for EPA Superfund
staff, State Superfund programs and other Federal agencies working
on Superfund sites, and EPA contractors working for the EPA Super-
-------
fund program. Users in these groups can call Syracuse Research
Corporation (202)479-0881 to be put on the mailing list.
EPA's Office of Solid Waste (OSW) requests that their users
(i.e., OSW staff, contractors, State solid waste programs) call the
Health Assessment Section (202)260-4761 to obtain copies of the
HEAST. Regional OSW staff are reminded that copies are sent to all
EPA Regional libraries.
Users of the HEAST in EPA's Office of Air and Radiation and
State air programs should call Kelly Rimer of EPA's Office of Air
Quality Planning and Standards at (919)541-2962.
All other users must purchase the document from:
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
(703)487-4650
For ordering information, call the NTIS Subscriptions
Department at (703)487-4630. NTIS normally ships 4th class United
States mail. Therefore, users may wish to consult with NTIS
concerning the use of an overnight delivery service. The NTIS
order number is PB93-921199.
-8-
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WHAT'S NEW IN THE JULY 1993 SUPPLEMENT NO. 1
GENERAL CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY
The changes in this version of the HEAST reflect changes in
IRIS through June 1, 1993. It is also current with RfD/RfC and
CRAVE Work Group activities through May 1, 1993. Cross-references
between tables may refer the user to the March 1993 HEAST Annual
Update for that information.
CHEMICAL-SPECIFIC CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY
A. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 1: SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Bromoethene
Added to Table 1. An indicator was added to show that the chronic
inhalation RfC is now available on IRIS. The chronic inhalation
RfC on IRIS was adopted as the subchronic inhalation [RfC].
Bromoform
A comment was added to indicate that the chronic inhalation RfC is
considered not verifiable (02/11/93) by the RfD/RfC Work Group.
Chlorobenzilate
A comment was added to indicate that the chronic inhalation RfC is
considered not verifiable (02/11/93) by the RfD/RfC Work Group.
Cyanazine
No change in the tables. Reference to the 1993 Revised and Updated
Drinking Water Quantification of Toxicologic Effects for Cyanazine
was added.
Dinitro-o-cresol, 4,6-
A comment was added to indicate that the chronic inhalation RfC is
considered not verifiable (02/11/93) by the RfD/RfC Work Group.
Endosulfan
The chronic oral RfD was withdrawn from IRIS (12/01/92) . The
chronic oral [RfD] was changed to reflect the value currently under
review by the RfD/RfC Work Group (11/04/92). The chronic oral
[RfD] was adopted as the subchronic oral [RfD].
Hexachlorobutadiene
The chronic oral RfD was withdrawn from IRIS (05/01/93) . The
chronic oral [RfD] was changed to reflect the value currently under
review by the RfD/RfC Work Group (04/01/93).
-9-
-------
Isophorone
No change in the tables. Reference to 1993 Revised and Updated
Drinking Water Quantification of Toxicologic Effects for Isophorone
was added.
Methoxvethanol, 2-
The chronic oral [RfD] and the subchronic oral [RfD] were moved
from Table 1 to Table 2 because they were derived from methodology
that is not current with the methodology used by the RfD/RfC Work
Group.
Methyl Ethyl Ketone
An indicator was added to show that the chronic oral RfD is now
available on IRIS.
Methylene-bis(2-chloroaniline), 4,4'-
A comment was added to indicate that the chronic inhalation RfC is
considered not verifiable (02/10/93) by the RfD/RfC Work Group.
Metribuzin
Added to Table 1. An indicator was added to show that the chronic
oral RfD is now available on IRIS. The chronic oral RfD on IRIS
was adopted as the subchronic oral [RfD].
Naphthalene
The record for Naphthalene, which was inadvertantly omitted from
Table 1 of the March 1993 Annual HEAST, has been replaced.
Nitroaniline, 2-
The record for Nitroaniline, 2-, which was inadvertantly omitted
from Table 1 of the March 1993 Annual HEAST, has been replaced.
Trifluralin
No change in the tables. Reference to 1993 Revised and Updated
Drinking Water Quantification of Toxicologic Effects for
Trifluralin was added.
Zinc (metallic)
The record for Zinc (metallic) , which was inadvertantly omitted
from Table 1 of the March 1993 Annual HEAST, has been replaced.
B. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 2: ALTERNATE
METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
Methoxvethanol, 2-
The chronic oral [RfD] and the subchronic oral [RfD] were moved
from Table 1 to Table 2 because they were derived from methodology
that is not current with the methodology used by the RfD/RfC Work
Group.
-10-
-------
C. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3: CARCINOGENICITY
Chloromethane
The record for Chloromethane, which was inadvertantly omitted from
Table 3 of the March 1993 Annual HEAST, has been replaced.
Cyanazine
Carcinogenicity information was added to Table 3 from the 1993
Revised and Updated Drinking Water Quantification of Toxicologic
Effects for Cyanazine.
D. CHANGES ON HEAST TABLES 4A AND 4B: RADIONUCLIDE CARCINO-
GENICITY - SLOPE FACTORS
No new radionuclide slope factors were added to Tables 4A and
4B, and none of the slope factors listed in the March 1993 HEAST
Annual Update were changed.
-11-
-------
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