vxEPA
            United States
            Environmental Protection
            Agency
             Office of Pesticides
             and Toxic Substances
             Washington, DC 20460
EPA-560/TIIS-81-005
August 1981
            Toxic Substances
TSCA Chemicals in
Commerce Inventory:

Regional and State
Perspectives

Toxics Integration Information
Series

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                                     EPA-560/TIIS-81-005
      TSCA Chemicals
 in Commerce Inventory:
Regional and State Perspectives
             Prepared by:
           Daryl L. Kaufman

          with assistance from:
             Bob Janney
            Donn Viviani

               and

            Jean Bellinger
            Denny Daniels
            Patricia Grim
            Chris Harvey
           Karen Richardson
      United States
      Environmental Protection Agency

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FOREWORD
The TSCA Chemicals In Commerce Inventory;  Regional and State Perspectives
is designed to provide EPA Regional and State officials with a better
understanding of how the TSCA Inventory can be used to meet regional
needs.  This particular study addresses those chemicals that were
reported for the 1977 TSCA Inventory (nonconfidential), but produced
exclusively in each of the ten EPA regions.  Because the total number of
region-specific substances was so large, a cut-off production volume was
selected allowing us to highlight the high volume chemicals produced
solely in each region.

The report is divided into three parts.  Part I briefly discusses the
Inventory, the cut-off production volume selected, limitations to
Inventory use, and provides a summary of the remainder of the report.
Part II provides the results of the Inventory computer runs and two
charts further illustrating these results.  Part III contains a regulatory
analysis of the selected high production volume chemicals.  This was
obtained by accessing various on-line data systems and cross-matching
these chemicals with other EPA chemical lists and regulatory documents.
An Appendix is included at the end of this report describing on-line
information sources listed in an in-house data file (CHEMTRAX).

This report can be used to help the states compile priority lists of
chemicals, identify major producers of state (or region) specific
chemicals, and to determine those chemical manufacturers having to
comply with chemical-specific regulations.

We hope you find this study valuable.  Any request or comments you may
have can be directed to the Information and Analysis Staff at 202-382-2249.
                                   Walter W. Kovalick, Jr.
                                   Director
                                   Integration Staff
                                 iii

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                               CONTENTS
Executive Summary	    vii

Part I.    Introduction	      1

Part II.   Results	      5

     CHART A:     Total Number of Chemicals by State	      9
     CHART B:     Regulatory Status of "Exclusive" Chemicals  .  .     12

Part III.  Regulatory Status	     15

Appendix A:  Description of CHEMTRAX Files  ... 	     81

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EXECUTIVE SUMMARY





This report was prepared by the Office of Toxics Integration using the




TSCA Chemicals in Commerce Inventory (TSCA Inventory) and other information




systems to identify those chemicals produced in only one EPA region.




The study is intended to display for EPA Headquarters, Regional, and




State decision-makers those chemicals which, in terms of production, are




unique to one region and/or state.  Such chemicals may well be of greater




regional or local concern than national.  Some of the major report




findings are:







     o    Almost one-half of the chemicals listed in the nonconfidential




          TSCA Inventory is region—and/or state—unique (21,688 regionally




          unique substances out of an approximate 43,000 reported for




          the initial public Inventory).  The calculated 21,688 figure




          may be an overestimate due to the Inventory limitations discussed




          in the introduction to this report.








     o    Of these 21,688 region unique substances, only 440 are produced




          in quantities equal to, or exceeding, 10-50 million Ibs/yr




          (the minimum quantity range used to define high production for




          this report).  This total may also be affected by the Inventory




          limitations.








     o    Of the 440 substances used for this analysis very few are




          presently regulated by the Federal Government.  One hundred




          and twenty-eight of these chemicals were found to have Federal
                                 vii

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     regulatory citations.  All but five of these citations, however,




     pertained to information gathering or testing activities,




     usually in proposed rules.  If the uses of these chemicals




     were as regionally unique as their production, the states might




     well be the potential leaders in any regulations focused on




     these chemicals.






o    With regard to the region-by-region analysis, Region II (New




     York, New Jersey, Puerto Rico, and the Virgin Islands) has




     the largest total of exclusively produced substances (8,430).




     However, Region VI (Texas, Louisiana, Oklahoma, New Mexico,




     and Arkansas) produces the largest number of chemicals at or




     above the 10-50 million Ibs/yr production volume range.




     (Because of the widespread use of petroleum and natural gas as




     chemical feedstocks, the geographic profile of the chemical




     industry parallels the geographic profile of petroleum and




     natural gas sources in Region VI, and chemical processors in




     Regions II and VI.)






o    This study was conducted using the original, non-confidential




     TSCA Inventory data on some 43,000 chemicals (at the   •"•-.  time




     this automated data was obtained, the Inventory supplements




     containing an additional 11,000 chemicals had not been




     computerized).  Slightly less than half of the chemicals on




     the complete Inventory (public and confidential, including all




     Inventory supplements) have some type of confidentiality




     claim filed against them.  Of particular relevance is  the fact




     that approximately 20% of the Inventory chemicals have
                               viii

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confidentiality claims associated with plant site reported for




them.  When further analyzed to see what effect this would




have on the 440 high production volume chemicals surveyed in




this analysis, it appeared that confidentiality claims did not




alter the findings.  Approximately 5% of the 440 chemical




substances have confidentiality claims filed against them of which




less than half of these claims indicate the chemical was produced




in more than one region.  In these instances, the production




volumes were too low (most of the time less than 1,000 Ibs.




or no 1977 production data was reported) to make a significant




difference in the results discussed in this report.
                          ix

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PART I; INTRODUCTION



Under the authority of TSCA, most manufacturers, processors,  and  importers

of chemical substances are required to:   (1) report  the  identity  of  each

chemical substance manufactured at each site or imported for  a commercial

purpose; (2) estimate the amount imported or manufactured during  calendar

year 1977; and  C3) indicate whether the substance is manufactured and

used only within one site.  This list of chemicals, called the TSCA

Chemicals in Commerce Inventory, presently contains over 55,000 chemical

entries; however, only 43,000 data entries were accessible when this

study was conducted.  This report identifies chemicals produced exclusively

in each EPA region as reported in the nonconfidential files of the TSCA

Inventory, and examines the regulatory status of these substances using

the EPA Chemical Activities Status Report (EPACASR), Federal  Register

Search System (FRSS)*, CHEMTRAX and other information sources.



Because of the large number of chemicals produced exclusively in  each

region, the production volume range of 10-50 million Ibs/yr was chosen

as the cutoff for a more detailed analysis.  (This production range

ensures that at least one chemical will be listed for each EPA region.)

Some 440 chemical substances were reported as produced "exclusively" at

or above 10 million Ibs/yr in the nonconfidential initial TSCA Inventory.

Chemicals exclusively produced at or above these volumes are analyzed in

this report for regulatory status,  states in which produced,  and possible

reasons why these chemicals are only produced in the state/region.
*0ne limitation of the FRSS is that it covers only regulatory actions
 occurring since January 1, 1978; any regulation or announcement
 issued before then is not included.

                                     1

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Since the production data used in this report are based on the TSCA

Inventory, the limitations of the use of Inventory data must be acknowledged:


(1)  Due to the confidentiality requirements of TSCA, (a) some of these

     chemicals may be listed in the confidential Inventory for other

     regions; or (b) chemicals not listed at all in the public Inventory
 ^
     may be listed as region-unique in the confidential Inventory; and

     Cc) the nonconfidential Inventory did not contain the complete

     listing of 55,000 substances at the time of this analysis.



(2)  Excluded are all mixtures, pesticides, food additives, drugs,

     cosmetics, tobacco, and substances that have not been produced or

     processed since 1974, or presently produced only in small quantities

     for research and development purposes.



(3)  The Inventory reporting requirements stipulate that volumes be

     reported in "order of magnitude" ranges (I.e., less than 1,000 Ibs,

     1,000 Ibs to 10,000 Ibs, 10,000 Ibs to 100,000 Ibs, etc.).  This

     inhibits estimation of production volumes.  Also, the imprecise

     definitions of classes of chemical substances can result in underestimation

     of U.S. production of a specific chemical substance.


(4)  The exclusion of small businesses from the final Inventory reporting

     rules (chemicals were not required to be reported unless they were

     produced at a plant site, (a) at which at least 30 percent of the

     total output was a "Chemical and Allied" or "Petroleum Refining"

     product,  (b) which produced at least 1,000,000 pounds of chemicals

     not excluded by TSCA, or  (c) in quantities of at least 100,000 Ibs.

      (See 42FR64572, December 23, 1977).

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The 440 "high-production" region-specific chemicals were cross-matched

with the second edition of the EPA Chemical Activities Status Report

(EPACASR) and EPA's CHEMTRAX data base.  EPACASR is an interactive

chemical data base which contains the only comprehensive summary of all

major Agency activities on chemicals.  Chemicals listed in EPACASR are

listed under the EPACASR heading in Part III of this report (p. 15) with

only very basic information, but additional detailed information, such

as the nature of a program office activity, reasons for undertaking the

action, and contact person can be obtained from the publication itself.

CHEMTRAX contains regulatory, assessment, and testing information on

chemicals of interest to the Office of Toxic Substances.  The latter

system includes data files from such other Federal agencies as the

National Cancer Institute and the Occupational Safety and Health Admini-

stration.  Appendix A provides a description of the files appearing in

the CHEMTRAX search for the 440 region-specific chemicals.*


The 440 chemicals were also compared with the EPA Carcinogen Assessment

Group's (GAG) list of 150 substances for which cancer assessments have

been prepared to determine if any of the region-specific chemicals were

included.  (The sources of information used in selecting agents as

candidates for the list are of two types:  chemicals which the Carcinogen

Assessment Group previously has evaluated and has determined pose a

potential human cancer risk; and chemicals, the carcinogenicity of which
*Because many CHEMTRAX files are not EPA-related, these entries do not appear
 in the EPACASR.  Conversely, there are some file types in EPACASR (e.g.,
 technical assistance data)_ that are not contained in CHEMTRAX.  Since the
 closing date for EPACASR data submission was July 1980, it is possible that
 a chemical with a CHEMTRAX entry (such as a preparation of a risk assessment)
 may not have a similar EPACASR entry because the report was completed after
 July 1980.  CHEMTRAX files not included in PART III or in Appendix A, because
 no exclusive chemical  was reported for them, are available at EPA Headquarters.

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the GAG reviewed because one or more of three organizations — the


International Agency for Research on Cancer (IARC), the National Cancer


Institute Bioassay Program which has been reorganized into the National


Toxicology Program (NTP), and the Food and Drug Administration (FDA) of


the U.S. Department of Health and Human Services — had concluded that

 f
these chemicals are potentially human carcinogens.  Substances were


placed on the GAG list only if they had been demonstrated to induce


malignant tumors in one or more animal species or to induce benign


tumors that are generally recognized as early stages of malignancies,


and/or if positive epidemiologic studies indicated they were carcinogenic.


Although the GAG has determined that there is substantial evidence of


carcinogenicity for each chemical substance on the list, the data varies


to some extent with respect to the scope and quality of the studies.*)


The only chemical appearing on CAG's list was PCB, a substance reported


on the nonconfidential Inventory to be produced only in Region V.



The remainder of this paper is organized into two parts.  Part II presents


the results section of the paper.  Conclusions drawn from the computer


runs of the three data files mentioned above are summarized.  Possible

reasons why chemicals are produced exclusively in a particular State are


listed, and potential implications of such state-specific production for


state and regional officials are mentioned.



Part III contains the results of the computer runs of the three data


files and is organized by region.  The FRSS searches are presented first


(the Federal Register citation is given along with a brief description


of the announcement/action) followed by the EPACASR and CHEMTRAX data.
*July 14, 1980 preamble to GAG list.

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PART II;  RESULTS



As can be seen on Chart A, approximately one-half of the nonconfidential

Inventory is region-specific.  Four-hundred and forty  (440) of these

regionally unique substances are produced in or above  the 10-50 million

Ibs/yr range, the majority of which appear to be unregulated by the

Federal Government.*  The Government may not be currently interested

in these chemicals.



EPA Region II states produce the most region-specific  substances  (8,430),

whereas Region VI produces the most in or above the 10-50 million Ibs/yr

range.  The regulatory actions/announcements appearing in the FRSS

search that recurred most often were the TSCA Section  8(a) Proposed

Reporting Rules  (February 29, 1980) and the list of chemicals recommended

by the TSCA Interagency Testing Committee (ITC) for priority consideration

for testing for  adverse health and environmental effects under Section 4

of TSCA.



Certain factors  may be the primary impetus for establishing plant sites

in a particular  area.  For example, of the total number of chemicals

produced exclusively in Region VI, the majority are located in Texas and

Louisiana, both  situated on the Gulf of Mexico and near petroleum supplies.

Large cities having access to harbors or major transportation routes
*The Federal Register Search System  (FRSS) was used to search for regulatory
 citations.  A number of reasons may explain this lack of activity, including
 the possibility of a dearth of health effects information for these substances,
 the Government may not be currently interested in these chemicals, or the
 substances may be non-toxic.  It is important to remember that the Inventory
 is a compilation of chemicals in commerce, many of which are non-toxic.

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appeared to be the sites for chemical plants exclusively producing


substances in that region at or above 10-50 million Ibs/yr.  For example,


of the 34 chemicals produced at or above 10-50 million Ibs/yr (see p.


 9) exclusively in Region III, almost one-third were produced in Baltimore,


Maryland.
  /


Various factors such as those listed below may be considered when selecting


plant locations:



     o    Proximity to waterways for manufacturing and transportation


          purposes.


     o    Proximity to new material, such as petroleum, natural gas, or


          to feedstock plants which can cut transportation and storage


          costs.


     o    Proximity to major users (and buyers) of the product, which


          can also cut transportation costs.


     o    Amenable tax laws.




Chart A (page  9) lists, by region and states, the number of chemical


substances produced "exclusively" within them.  The total of these


chemicals in quantities at or above 10-50 million lbs;/yr for each region


may exceed the sum (in or above this production range) of the state


totals in each region.  There are instances where the substance is


produced in one EPA region, but in more than one state in that region.


This is apparent from the data provided in Chart A.  In both Regions IV


and VI, the sum of the states' total number of chemicals produced in or


above 10-50 million Ibs/yr is larger than the total number of individual


chemicals produced in the same production ranges for those regions.


Region IV exclusively produced 38 distinct chemicals, yet the summed

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state totals equal 39.  Region VI exclusively produced 227 distinct


chemicals, whereas the summed state totals equal 236.  The difference


between the totals in Region IV is one; in Region VI, nine.  This indicates


that one chemical substance was produced in two states in Region IV and


as many as nine chemicals were produced in more than one state in Region  ,
   /

VI.  As was indicated on Chart A, these totals do not account for multiple


plant sites.  If a substance was manufactured in two or more plants in


different cities, so long as they were all located within the same


state, the chemical counted as only one exclusively produced substance


for that state.




For the 440 high production chemicals there were 128 total FRSS chemical


citations on Chart B (see p. 12) but they pertain to only 95 specific


chemical substances.  Although Regions I and VII, respectively, produce one


and nine "exclusive" chemicals at or above the 10-50 million Ibs/yr


range, no regulatory action was shown for any of them.  A comparison of


the larger numbers of total region-specific chemicals with the number of


chemicals for which a regulation/announcement has been proposed shows


that very few substances are under any Federal regulatory consideration.


Thus, EPA regions and state governments will not have to be concerned


with existing regulatory requirements at this time.  However, when


proposed TSCA section 8 (a) rules are promulgated, manufacturers will be


subject to those reporting and data submission requirements for those


chemicals cited in the proposed rule.




The majority (approximately 78 percent) of these chemicals (the 440


exclusively produced chemicals at or above 10-50 million Ibs/yr for all


regions) are unregulated and not under immediate consideration for


potential regulation by EPA and/or other Federal agencies.

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As this paper was developed, the significance of confidentiality claims

in the TSCA Inventory as it relates to this analysis was considered.

Substances for which the chemical identity was declared confidential are

not included in the confidential computer file.  These chemical identities

remain in the non-computerized Master Inventory File and are accessible
 j
only manually by EPA staff.  The total number of claims related to chemical

identity, however, are less than 7% (2,000-3,000 chemicals) of the Inventory

run for this analysis (approximately 43,000 chemicals) and, therefore,

would appear not to drastically affect the findings discussed in this paper.




Information contained in the confidential computer file are confidentiality

claims for several other aspects of the chemical (:L,e., site-limited,

manufacturer identification number, production, corporation, import, but

not chemical identity).  It was determined from this information that

only 22 of the 440 chemical substances have confidentiality claims reported

for them.  Of the 22, only 9 proved to be no longer region-specific.  That

is, some reporting aspect of these nine substances was claimed confidential

in at least one other region.  This does not affect the results of this

study because all but one of these substances were produced in quantities

less than 10-50 million Ibs/yr in that other region according to the

confidential data.  The remaining substance (of the nine), although

produced in more than one region, is not being considered for assessment

or regulation.  The confidential claims for 13 of the 22 substances were

made by manufacturers located in the same regions in which the substances

were produced as r.eported for the public Inventory.  Thus, these 13

substances can still be considered region-specific.

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       CHART A:  TOTAL NUMBERS OF CHEMICALS BY REGION AND STATE


                         Total Number of Exclusively    *Total Number of Exclusively
                         Produced Substances (All        Produced Substances In Or
Regions/States               Production Volumes)	     Above 10-50 Million Lbs/Yr


  Region I       i                 1,228                              1

     CT                              463                              0
     MA                              385                              0
     RI                              324                              0
     NH                               40                              0
     ME                               21                              1
     VT                                00


  Region II                        8,430                             15
NJ
NY
PR
VI
4,419
4,250
12
1
5
5
5
0
  Region III                       2,484                             34

     PA                            1,751                              6
     WV                              365                              7
     DE                              212                              6
     MD                              153                             13
     VA                               41                              2
     DC                                10
  Region IV                        2,519                             38

     SC                              792                              2
     NC                              508                              0
     TN                              292                             11
     KY                              288                              6
     AL                              269                              7
     GA                              226                              2
     FL                              140                              6
     MS                               59                              5
*Does not reflect multiple sites (i.e., same chemical produced in more than
 one site).   A chemical produced at more than one site in the same State
 counts for only one substance.

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      CHART A:  TOTAL NUMBERS OF CHEMICALS BY REGION AND STATE (continued)
                         Total Number of Exclusively    *Total Number of
                         Produced Substances (All        Produced Substances In C
Regions/States               Production Volumes) ___     Above 10-50 Million Lbs/
/
Region V ;
IL
OH
MI
WI
MN
IN
Region VI
TX
LA
OK
AR
NM
Region VII
MO
IA
KS
NE
Region VIII
CO
UT
MT
WY
ND
SD
Region IX
CA
NV
HI
AZ
GU
3,875
1,360
1,079
672
328
361
187
1,200
791
312
109
27
1
. 426
320
72
28
6
196
113
59
22
3
0
0
1,218
1,208
6
3
1
0
43
10
15
8
3
2
5
227
119
97
18
1
1
9
2
4
1
2
18
4
1
11
2
0
0
41
38
2
0
1
0
*See footnote  on previous page.

                                       10

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      CHART A:  TOTAL NUMBERS OF CHEMICALS BY REGION AND STATE  (continued)


                         Total Number of Exclusively    *Total Number of Exclusively
                         Produced Substances (All        Produced Substances In Or
Regions/States               Production Volumes)	     Above 10-50 Million Lbs/Yr


  Region X        :                   112                             14

     OR                               53                              4
     WA                               45                              6
     ID                               14                              4
     AK                                00

                    TOTAL:        21,688                            440
*See footnote on page 9.

 Note that the sum of 440 equals the number of specific  ("exclusive") chemicals
 produced in the 10 regions.  If the individual State totals were summed, a
 result of 450 substances would be obtained.  This latter figure includes those
 chemicals produced in more than one State in a region.

 There were some instances where a substance was produced in the 10-50 million
 Ibs/yr range and in lesser quantities at other sites in the same State.
 For this report, only those States which are the sites of plants producing
 10-50 million Ibs/yr are included.
                                      11

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                 CHART B:   REGULATORY STATUS OF "EXCLUSIVE" CHEMICALS PRODUCED
                           IN OR ABOVE 10-50 MILLION POUNDS PER YEAR, BY REGION
                           AND ACTION/NOTICE
EPA Rule/Other
Citation  (Date of
Federal Register)
        /
Proposed  TSCA*
Sec. 8(a) 2/29/80

1980 ITC  List
10/7/80

Proposed  TSCA
Sec. 8(d) 12/31/80

CWA Designated Hazard
Substance (sec. 311)
3/13/78

NTP 1979  Annual Plan
 - Lifetime Bioassay
7/24/79

NTP 1979  Annual Plan
Salmonella Mutagen
Assay  7/24/79

NTP 1980  Annual Plan
- Test Chemical 2/8/80

Total  No. of Specific
Chemicals*
                  REGIONS



I  II  III  II  Y.  VI   VII   VIII

      3    14  12  12    40    —      2


—    2     5    3    1    13    —      1
                                                   Total Chemi
                                           IX   JC  for Each Ac

                                            52       "90
                                                          25
                 1    3    1   —
—    3    16   12   13   42
                                            5   2     95/128
'KEY+

TSCA  Sec.  8(a);


ITC List:
 TSCA Sec.  8(d);
Designated  Hazardous
Substances:
 Record maintenance and submissions of information on 2,300
 chemicals to the Administrator.

 The new chemical list selected for review by the Interagency
 Testing Committee (members reprejsent other Federal agencies)
 for possible future testing rules under section 4 of TSCA.
 To date only two test rules have been proposed.

 Health and safety study submissions to EPA as required by
 TSCA.
 Chemicals for which a hazardous discharge reporting level
 was promulgated under section 311 of the Clean Water Act.
                                           12

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National Toxicology Program   Life time bioassay in process.
Lifetime Bioassay;

National Toxicology Program   Chemicals for which an Ames Test will be conducted.
Salmonella Mutagenicity
Assay;

National Toxicology           Chemicals for which health effects test will be
Prbgram Test Chemical;        conducted.
*NOTE;    The totals reflect the number of individual chemicals produced in that
          region, some of which are listed for more than one action/notice.

 See Appendix A for more detailed definitions.
                                    13

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                     PART III


           Regulatory/Assessment Status

           of High-Volume, Region-Unique

                     Chemicals
FRSS entries and EPACASR/CHEMTRAX entries are listed on separate
pages, but are located sequentially .(FRSS entries appear first) for
each region.
                           15

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                               REGION I
The one chemical substance, thermal hydrolyzed starch,  (CAS# 68909-00-2)




exclusively manufactured in Region I between 10-50 million Ibs/year was not




under consideration for any regulation as reported for the FRSS between




January 1, 1978, and October 8, 1980, when the search was completed.  There were




no chemical substances exclusively produced above the 10-50 million Ibs/year




range.
                                     17

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                               REGION I
No entries in EPACASR or CHEMTRAX.
                                   19

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                               REGION II
Three chemicals exclusively manufactured in Region II at or above 10-50 Ibs/yr



are subject to the following ITC notice and proposed TSCA section 8(a) rule.
   /


Note that two of these substances are listed for both actions.  Chemicals for



each action are listed below by their CAS number and CAS preferred name as they



appeared in the Federal Register.







Federal Register Notices







A.   45FR66506, October 7, 1980







     Notice:  Environmental Protection Agency, Office of Pesticides and Toxic



     Substances, Toxic Substances Control Act.







     Interagency Testing Committee; chemicals for review for possible testing



     recommendation under section 4 of TSCA.  Comment period closed January 5,



     1981.







     CAS #          CAS Preferred Name







     95-49-8        l-Chloro-2-methyl benzene



     5216-25-1      l-Chloro-4-(trichloromethyl) benzene
                                     21

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B.   45FR13657, February 29, 1980



     Proposed rule; Revision of 40CFR712, Environmental Protection Agency,

     Office of Pesticides and Toxic Substances, Toxic Substances Control Act

   /
                  V
     Section 8(a) - proposed recordkeeping and reporting requirements.



     CAS #          CAS Preferred Name



     95-49-8        l-Chloro-2-methyl benzene

     5216-25-1      l-Chloro-4-(trichloromethyl) benzene

     68797-39-7     l(or 3)-(carboxymethyl)-4,5-Dihydro-l-(2-
                    Hydroxyethyl)-2-undecyl-, salt with .alpha.-
                    sulfo-.omega.-(tridecyloxy)poly(oxy-1,2-
                    ethanediyl) lH-Imidazolum,monosodiuiri salt
                                      22

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                          REGION II

l-chloro-2-methyl benzene (95-49-8)

EPACASR

-    Analytical Methods Development; completed March 1980
     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

l-chloro-4-(trichloromethyl)-benzene (5216-25-1)

EPACASR

     Analytical methods development; completion date March 1982
     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA setion 8(a) actions

1(or 3)-(Carboxymethyl)-4,5-dihydro-l-(2-hydroxyethyl)-2-undecyl-
iN-imidazolium salt  (68797-39-7)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions
                               23

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                              REGION III
Sixteen chemicals exclusively manufactured in Region III at or above 10-50




million Ibs/yr are subject to the following notices and proposed and final-




regulations.  Note that some of these substances are listed for more than one




action.  Chemicals are listed below for each action by their CAS number and




CAS preferred name as they appeared in the Federal Register.









Federal Register Notices








A.   45FR66506, October 7, 1980








     Notice; Environmental Protection Agency, Office of- Pesticides and Toxic




     Substances, Toxic Substances Control Act








     Interagency Testing Committee; chemicals for review for possible testing




     recommendation under section 4 of TSCA.  Comment period closed January 5,




     1981.
     CAS ft
CAS Preferred Name
     563-47-3       3-Chloro-2-methylpropene




     13414-54-3     1- (2-methyl-2-propenyl)oxy -2-nitrobenzene




     13414-55-6     2,3-Dihydro-2,2-dimethyl-7-nitro-benzofuran




     36452-21-8     1,3,5-Triazine-2,4,6(lH,3H,5H)-trione, disodium salt




     68298-46-4     2,3-Dihydro-2,2-dimethyl-7-benzofuranamine
                                     25

-------
B.   45FR13657, February 29, 1980




     Proposed rule; Revision of 40CFR712, Environmental Protection Agency,

     Office of Pesticides and Toxic Substances, Toxic Substances Control Act


  /

     Section 8(a) - proposed recordkeeping and reporting requirements.
     CAS #
CAS Preferred Name
     13414-58-9     2-(2-methylalkyl)-6-nitro-phenol

     2027-17-0      2-(1-methylethyl)-naphthalene

     95-08-9        2-ethyl- ,1, 2-ethanediylbis (oxy-2, l--ethanediyl
                    ester)butanoic acid

     1563-38-8      2,3-dihydro-2,2-dimethyl-7-benzofuranol

     12013-15-9     Copper hydroxide sulfate

     13188-60-8     Dodecanedioic acid, cmpnd. with 1,6-hexanediamine (1:1)

     13414-54-5     1- (2-methyl-2-propenyl)oxy -2-nitrobenzene

     13414-55-6     2,3-Dihydro-2,2-dimethyl-7-nitrobenzofuran

     22527-63-5     3-Hydroxy-2,2,4-trimethylpentyl ester benzoate
                    (isobutyric acid)

     25339-56-4     Heptene

     36452-21-8     1,3,5-Triazine-2,4,6(lH,3H,5H)-trione, disodium salt

     37292-80-1     Silicic acid, calcium iron magnesium salt

     68298-46-4     2,3-Dihydro-2,2-dimethyl-7-benzofuranamine

     68411-80-3     1,3-Isobenzofurandione, oxidized
                                     26

-------
C.   44FR43433, July 24, 1979


     Notice; Public Health Service, National Toxicology Program (1979
     Annual Plan).  Lifetime bioassay in progress.

   /
     CAS ft        ""' CAS Preferred Name


     563-47-3       3-Chloro-2-methylpropene


D.   45FR8902, February 2, 1980


     Notice; Public Health Service, National Toxicology Program (1980
     Annual Plan).  Test Chemical.


     CAS #          CAS Preferred Name


     563-47-3       3-Chloro-2-methylpropene
                                      27

-------
                         REGION III

2-(2-methylallyl)-6-nitrophenol (13414-58-9)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

2-(l-methyethyl}-naphthalene  (2027-17-0)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

-    TSCA section 8(a) actions

2-ethyl-, 1,2-ethanediylbis  (oxy-2,1—ethanediyl)ester, butanoic
acid (95-08-9)

EPACASR
     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

3-chloro-2-methyl propene (563-47-3)

EPACASR

     No entries in EPACASR

CHEMTRAX

     ITC Master File
-    ITC Phase I Score File
     ITC Phase II Score File
     ITC Phase III Score File
     ITC Phase IV Score File
     NCI Bioassay Chemicals
     Preliminary List Chemicals

2,3-dihydro-2,2-dimethyl-7-benzofuranol (1563-38-8)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980
                                29

-------
     CHEMTRAX


          TSCA section 8(a) actions


•    Copper hydroxide sulfate (12013-15-9)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980
   /

     CHEMTRAX


     -    TSCA section 8(a) actions


•    Dodecanedioic acid, compound with 1,6-hexanediamine (1:1)  (13188-60-8)


     EPACASR


     -    Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


     -    TSCA section 8(a) actions


•    1-  (2-methyl-2-propenyl)oxy -2-nitrobenzene  (13414-54-5)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980



     CHEMTRAX


          TSCA section 8(a) actions


•    2,3-dihydro-2,2-dimethyl-7-nitrobenzofuran  (13414-55-6)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions


•    3-hydroxy-2,2,4-trimethylpentyl ester benzoate isobutyric  acid

     (22527-63-5)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980



     CHEMTRAX


          TSCA section 8(a) actions
                                      30

-------
•    Heptene  (25339-56-4)




     EPACASR




          Section 8(a) regulation; proposed February 29, 1980




     CHEMTRAX




          TSCA section 8(a) actions




•    l,3,5-triazine-2,4,6(lH,3H,5H)-trione, disodium salt  (36452-21-8)




     EPACASR




          Section 8(a) regulation; proposed February 29, 1980




     CHEMTRAX




     -    TSCA section 8(a) actions




•    Silicic acid, calcium iron magnesium salt  (37292-80-1)




     EPACASR




          Section 8(a) regulation; proposed February 29, 1980




     CHEMTRAX




          TSCA section 8(a) actions




•    2,3-dihydro-2,2-dimethyl-7-benzofuranamine  (68298-46-4)




     EPACASR




          Section 8(a) regulation; proposed February 29, 1980




     CHEMTRAX




     -    TSCA section 8(a) actions




•    1,3-isobenzofurandione, oxidized (68411-80-3)




     EPACASR




          Section 8(a) regulation; proposed February 29, 1980




     CHEMTRAX




          TSCA section 8(a) actions




•    Isopropylated phosphate phenol  (3:1) (68937-41-7)




     EPACASR




     No entries for EPACASR






      —                             31

-------
CHEMTRAX
     TSCA section 8(e) actions
                                 32

-------
                               REGION IV
Twelve chemicals exclusively manufactured in Region IV at or above



10-50 million Ibs/yr are subject to the following notice and proposed and  .
   *


final regulations.  Note that some of the chemicals are listed for more than



one action.  Chemicals for each action are listed below by their CAS number



and CAS preferred name as they appeared in the Federal Register.







Federal Register Notices







A.   45FR66506, October 7, 1980







     Notice; Environmental Protection Agency/ Office of Pesticides and



     Toxic Substances, Toxic Substances Control Act







     Interagency Testing Committee; chemicals for review for possible testing



     recommendation under section 4 of TSCA.  Comment period closed January 5,



     1981.







     CAS #          CAS Preferred Name







     1772-25-4      1,3,6-Hexanetricarbonitrile



     2431-50-7      2,3,4-Trichloro-l-butene



     63494-59-7     2- ethyl(3-methyl-4-nitrosophenyl)amino -

                    .N—nethyl-ethanesulfonamide
                                      33

-------
B.   45FR13657, February 29, 1980



     Proposed rule; Revision of 40CFR712, Environmental Protection Agency,

     Office of Pesticides and Toxic Substances, Toxic Substances Control

     Act.
   *



     Section 8(a)-proposed recordkeeping and reporting requirements.



     CAS #          CAS Preferred Name



     106-31-0       Butanoic acid, anhydride

     12789-64-9     Iron titanium oxide

     13918-37-1     Fayalite

     22708-90-3     Silicic acid, aluminum salt (1:2)

     123-62-6       Propanoic acid, anhydride

     121-45-9       Phosphorous acid, trimethyl ester

     3982-91-0      Thiophosphoryl chloride

     111-91-1       1,l'-methylenebis(oxy) bis 2-chloroethane

     1772-25-4      1,3,6-Hexanetricarbonitrile

     2431-50-7      2,3,4-Trichloro-l-butene

     15075-85-1     9-Octadecene-l-sulfonic acid,  sodium salt  (Z)

     63494-59-7     2- ethyl(3-methy1-4-nitrosophenyl)amino -
                    N-methy1-ethanesulfonamide



C.   43FR10485, March 13, 1978



     Final rule; Environmental Protection Agency,  Clean Water Act

     Section 311 - Designated hazardous substance.


                                       34

-------
CAS #          CAS Preferred Name
123-62-6       Propanoic acid, anhydride
                                  35

-------
                           REGION IV

Butanoic acid,  anhydride  (106-31-0)

EPACASR

     Section  8(a) regulation; proposed  February  29,  1980

CHEMTRAX

     TSCA section 8(a)  actions

Iron titanium oxide  (12789-64-9)

EPACASR

     Section  8(a) regulation; proposed  February  29,  1980

CHEMTRAX

     TSCA section 8(a)  actions

Fayalite (13918-37-1)

EPACASR

     Section  8(a) regulation; proposed  February  29,  1980

CHEMTRAX

     TSCA section 8(a)  actions

Silicic acid, aluminum  salt  (1:2)  (22708-90-3)

EPACASR

     Section  8(a) regulation; proposed  February  29,  1980

CHEMTRAX

     TSCA section 8(a)  actions

Propionic anhydride  (123-62-6)

EPACASR

     Technical assistance data;  completed December 1977
     Regulation promulgated under Clean Water Act; August 29, 1979
     Section 8(a) regulation; proposed  February  29,  1980

CHEMTRAX

     TSCA section 8(a)  actions
-    Clean Water Act, section 311 chemicals
                                 3,7

-------
Phosphorous acid, trimethyl ester (121-45-9)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions
     TSCA section 8(e) actions
-    Assessment Division Chemical Hazard Information Profile  (CHIP)

Thiophosphoryl chloride (3982-91-0)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

l,l,l-methylenebis(oxy) bis 2-chloroethane  (111-91-1)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980
     Regulation promulgated under RCRA; May 19, 1980

CHEMTRAX

     ITC Master File
-    ITC Phase I Score File
     ITC Phase II Score File
     ITC Phase III Score File
-    TSCA section 8(a) actions
     Water program's 65 chemicals
-    RCRA Section 3001 - Hazardous Waste
-    Assessment Division Pre-CHIP Screenings
-    Preliminary List Chemicals

1,3,6-hexanetricarbonitrile  (1772-25-4)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions
                                 38

-------
•    2,3,4-trichloro-l-butene  (2431-50-7)

     EPACASR

          Section 8(a) regulation; proposed February 29, 1980

     CHEMTRAX

          TSCA section 8(a) actions
          For your, information  (see Appendix A for description)

•    (z)-9-octadecene-l-sulfonic acid, sodium salt (15075-85-1)

     EPACASR

          Section 8(a) regulation; proposed February 29, 1980

     CHEMTRAX

          TSCA section 8(a) actions

•    2- ethyl(3-methyl-4-nitrosophenyl)amino -N-methyl-ethane sulfonamide
     (63494-59-7)

     EPACASR

          Section 8(a) regulation; proposed February 29, 1980

     CHEMTRAX

          TSCA section 8(a) actions
                                      39

-------
                               REGION V
Twelve chemicals exclusively manufactured in Region V at or above 10-50



million Ibs/yr are subject to the following notice and proposed and final
   /                                                                        -


rules.  Note that some of the chemicals are listed for more than one action.



Chemicals for each action are listed below by their CAS number and CAS



preferred name as they appeared in the Federal Register.







Federal Register Notices







A.   45FR66506, October 7, 1980







     Notice; Environmental Protection Agency, Office of Pesticides and



     Toxic Substances, Toxic Substances Control Act







     Interagency Testing Committee; chemicals for review for possible testing



     recommendation under section 4 of TSCA.  Comment period closed January 5,



     1981.







     CAS #          CAS Preferred Name







     594-42-3       Trichloromethanesulfenyl chloride
                                      41

-------
B.   45FR13657, February 29, 1980



     Proposed rule; Revision of 40CFR712, Environmental Protection

     Agency, Office of Pesticides and Toxic Substances, Toxic Substances

  ,  Control Act



     Section 8(a)-proposed recordkeeping and reporting requirements.
     CAS #
CAS Preferred Name
     76-08-4        1,1,l-Tribromo-2-methyl-2-propanol

     39445-23-3     Calcium magnesium hydroxide

     58398-71-3     Calcium magnesium hydroxide oxide

     10257-55-3     Sulfurous acid, calcium salt (1:1)

     75-99-0        2,2-Dichloropropanoic acid

     133-06-2       !H-Isoindole-l,3(2H)-dione, 3a,4,7,7a-
                    tetrahydro-2-((trichloromethyl)thio)

     594-42-3       Trichloromethanesulfenyl chloride

     1121-70-6      4-Methyl-phenol, sodium salt

     7790-92-3      Hypochlorous acid

     13780-17-1     Phosphoric acid, calcium sodium salt (1:1:1)

     25167-81-1     Dichlorophenol

     67923-88-0     Ethyl-9,10-dihydro-9,10-anthracenediol



C.   43FR10485, March 13, 1978



     Final rule, Environmental Protection Agency, Clean Water Act

     Section 311-Designated hazardous substance.
                                       42

-------
CAS #          CAS Preferred Name









1336-36-3      PCB's




75-99-0        2,2-Dichloropropanoic acid




133-06-2    ,.   Captan
                                 43

-------
                          REGION V

1,1rl-tribromo-2-methyl-2-propanol  (76-08-4)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

Calcium magnesium hydroxide  (39445-23-3)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

Calcium magnesium hydroxide oxide (58398-71-3)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

Sulfurous acid, calcium salt  (1:1)  (10257-55-3)

EPACASR

     Control technology development; completed April 1979
     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

l,l'-biphenyl, chloro. derivs.  (1336-36-3)

EPACASR

     Analytical, methods development; completed August 1979
     Exposure assessment; completed May 1980
     Water quality criteria; completed November 1980
     Technical assistance data; completed December 1977
     Activities summary under TSCA;  completed May 1979
     Substitutes assessment; completed May 1979
                                 45

-------
          Preregulatory assessment; completed December 1979; another is in
          progress
          Preregulatory assessment; completed March 1979
          Regulation promulgated under section 307(a) of the CWA;
          February 2, 1977
          Regulation promulgated under section 311 of the CWA; August 29, 1979
          Regulation promulgated under FIFRA; October 29, 1970 .
          Regulation promulgated under TSCA; February 17, 1978
          Documentation/monitoring; completed June 1980
          Documentation/monitoring; completed August 1979
          Documentation/monitoring; completed September 1979
          Control technology development; draft completed February 1980
          Control technology development; completed July 1979

     CHEMTRAX

          ITC Master File
          ITC Phase I File
          TSCA section 8(a) actions
          TSCA section 8(e) actions
          CAG Chemicals
          IRLG Regulatory Development Chemicals
          Water section 311 chemicals
          IARC Monographs
     -    Water Pollution Control Federation
          NTP Testing Chemicals
     -    Hazardous Waste Site Chemicals

•    2,2-dichloro-propanoic acid (75-99-0)

     EPACASR

          Source assessment; continuing project
          Regulation promulgated under section 311 of the CWA; August 29, 1979
     -    Technical assistance data; completed June 1975
     -    Section 8(a) regulation; proposed February 29, 1980
     -    Technical assistance data; completed December 1977

     CHEMTRAX

          ITC Master File
          TSCA section 8(a) actions
          Clean Water Act, section 311 chemicals
          Active Ingredient in Registered Pesticides
          Acute Toxicity to Aquatic Organisms

•    3a,4,7,7a-tetrahydro-2-((trichloromethyl)thio)-iH-isoindole-
     l,3(2H)-dione (133-06-2)

     EPACASR

          Source assessment; completed July 1978
          Regulation promulgated under section 311 of. CWA; August 29, 1980
                                      46

-------
     Documentation/monitoring; completion date August 1983
     Documentation/monitoring; completed October 1977
     Documentation/monitoring; completion date June 1983
     Risk Assessment; completed January 1980
     Technical assistance data; completed December 1977
     Technical assistance data; completed June 1975
-    Preregulatory assessment; completed October 1980
     TSCA section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     ITC Master File
     ITC Phase III Score File
     TSCA section 8(a) actions
-    Water section 311 chemicals
     NCI Bioassay Chemicals
     Assessment Division Pre-CHIP Screenings
     RPAR Chemicals (Special Pesticides Review Division)
     Active Ingredients in Registered Pesticides
     Acute Toxicity to Aquatic Organisms
     NTP Testing Chemicals
     OSHA Carcinogens

Trichloromethanesulfenyl chloride (594-42-3)

EPACASR

     Technical assistance data; completed December 1977
     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

4-methyl-phenol, sodium salt (1121-70-6)

EPACASR

-    Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

-    TSCA section 8(a) actions

Hypochlorous acid (7790-92-3)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980
     Documentation/monitoring;  completed July 1979
-    Technical assistance data; completed December 1977

CHEMTRAX

     TSCA section 8(a) actions


 —                             47

-------
•    Phosphoric acid, calcium sodium salt  (1:1:1)  (13780-17-1)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


   ,  -    TSCA section 8(a) actions
                 V

•    Dichlorophenol  (25167-81-1)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980
          Summary review; completed December 1979


     CHEMTRAX


          TSCA section 8(a) actions


•    Phosphorous acid, pentadecasodium salt (62533-93-1)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions


•    Ethyl-9,10-dihydro-9,10-anthracenediol (67923-88-0)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions
                                       48

-------
                               REGION VI
Forty-two chemicals exclusively manufactured in Region VI at or above



10-50 million Ibs/yr are subject to the following notices and proposed and
   /

                 \-

final rules.  Note that some of the chemicals are listed for more than



one action.  Chemicals for each action are listed below by their CAS



number and CAS preferred name as they appeared in the Federal Register.








Federal Register Notices








A.   45FR66506, October 7, 1980








     Notice; Environmental Protection Agency, Office of Pesticides and Toxic



     Substances, Toxic Substances Control Act








     Interagency Testing Committee; chemicals for review for possible



     testing recommendation under section 4 of TSCA.  Comment period closed



     January 5, 1981.
     CAS #
CAS Preferred Name
     25340-18-5     Triethylbenzene



     79-02-7        Dichloroacetaldehyde



     719-32-4       2,3,5,6-Tetrachloro-l,4-benzenedicarbonyl dichloride



     4553-62-2      2-Methyl-pentanedinitrile



     17773-41-0     2-Hydroxy-4-(methylthio)-butanenitrile
                                      49

-------
     760-23-6       3,4-Dichloro-l-butene




     75-34-3        1,1-Dichloroethane




     13042-02-9     2-Hexenedinitrile




     4635-87-4      3-Pentenenitrile




     26545-73-3     Dichloropropanol




     110-88-3    "   1,3,5-Trioxane




     16529-56-9     2-Methyl-3-butenenitrile




     25322-20-7     Tetrachloroethane








B.   45FR13657, February 29, 1980








     Proposed rule; Revision of 40CFR712, Environmental Protection Agency,




     Office of Pesticides and Toxic Substances, Toxic Substances Control




     Act








     Section 8(a)-proposed recordkeeping and reporting requirements.
     CAS #
CAS Preferred Name
     3071-32-7      1-Phenylethyl hydroperoxide




     760-23-6       3,4-Dichloro-l-butene




     75-34-3        1,1-Dichloroethane




     13042-02-9     2-Hexenedinitrile




     110-57-6       l,4-Dichloro-2-butene




     4635-87-4      • 3-Pentenenitrile




     26266-68-2     2-Ethyl-hexenal




     26545-73-3     Dichloropropanol
                                      50

-------
126-99-8       2-Chloro-l,3-butadiene

110-88-3       1,3,5-Trioxane

16529-56-9     2-Methyl-3-butenenitrile

25265-77-4     2-Methyl-propanoic acid, monoester with
               2,2,4-trimethyl-1,3-pentanediol

26760-64-5     Methylbutene

25322-20-7     Tetrachloroethane

563-45-1       3-Methyl-l-butene

1070-00-4      Trioctyl aluminum

1116-73-0      Trihexyl aluminum

1529-59-5      Tridodecyl aluminum

1726-66-5      Tris(decyl)aluminum

23778-52-1     2,5,8,11,14-Pentaoxahexadecan-16-ol

79-02-7        Dichloroacetaldehyde

107-89-1       3-Hydroxy-butanol

583-91-5       2-Hydroxy-4-(methylthio)-butanoic acid

719-32-4       2,3,5,6-Tetrachloro-l,4-benzenedicarbonyl dichloride

1529-58-4  •    Tritetradecyl aluminum

1726-65-4      Trihexadecyl aluminum

3041-23-4      Trioctadecyl aluminum

3085-35-6      Butoxymethanol

3985-81-7      1-Octadecanol, aluminum salt

4553-62-2      2-Methyl-pentanedinitrile

6846-50-0      2-Methyl-propanoic acid, 2,2-dimethyl-l-
               (1-methylethyl-l,3-propanediyl ester)

10103-43-2     Thiosulfuric acid, monoammonium salt

14624-15-8     1-Dodecanol, aluminum salt

17773-41-0     2-Hydroxy-4-(methylthio)-butanenitrile
                                  51

-------
     19141-82-3     1-Hexadecanol,  aluminum salt



     23275-26-5     1-Hexanol, aluminum salt



     26303-54-8     1-Decanol, aluminum salt



     26761-50-2     9-Octadecenoic  acid (2)-,isooctyl ester



     27070-59-3     Cyclododecatriene

   /
                  V

     14624-13-6     1-Octanol, aluminum salt








C.   44FR77477, December 31, 1979








     Proposed rule; Environmental Protection Agency, Office of Pesticides



     and Toxic Substances, Toxic Substances Control Act








     Section 8(d) - proposed health and safety studies submissions.








     CAS #          CAS Preferred Name








     75-34-3        1,2-Dichloroethane



     126-99-8       2-Chloro-l,3-butadiene








D.   43FR10485, March 13, 1978








     Final rule, Environmental Protection Agency, Clean Water Act



     Section 311 - Designated hazardous substance.








     CAS #          CAS Preferred Name








     107-02-8       Acrolein
                                      52

-------
E.   44FR43431, July 24, 1979









     Notice; Public Health Service, National Toxicology Program (1979




     Annual Plan).   Salmonella mutagenicity assay.





   •e



     CAS #        *  CAS Preferred Name




     126-99-8       2-Chloro-l,3-butadiene




     107-02-8       Acrolein









F.   45FR8902, February 2, 1980









     Notice; Public Health Service, National Toxicology Program (1980




     Annual Plan).   Test Chemical









     CAS #          CAS Preferred Name









     107-02-8       Acrolein




     126-99-8       2-Chloro-l,3-butadiene
                                     53

-------
                          REGION VI

Number 2 Burner Fuel  (68476-30-2)

EPACASR

No Entries for EPACASR

CHEMTRAX
             V
     TSCA section 8(e) actions

1-phenylethyl hydroperoxide  (3071-32-7)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

3,4-dichloro-l-butene (760-23-6)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

1,1-dichlorpethane (75-34-3)

EPACASR

     Regulation promulgated under RCRA; May 19, 1980
     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     ITC Master File
     ITC Phase I Score File
     TSCA section 8(a) actions
     TSCA section 8(e) actions
-    Water Program's 65 Chemicals
     RCRA Section 3001 - Hazardous Waste
     Safe Drinking Water Act
     OSHA TLV

2-hexenedinitrile (13042-02-9)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980


  ^                              55

-------
CHEMTRAX

     TSCA section 8(a) actions

l,4-dichloro-2-butene (110-57-6)

EPACASR

     Regulation promulgated under RCRA; May 19, 1980
     Sectionv8(a) regulation; proposed February 29, 1980

CHEMTRAX

-    ITC Master File
     ITC Phase I Score File
     ITC Phase II Score File
     TSCA section 8(a) actions
     Preliminary List Chemicals

3-Pentenenitrile (4635-87-4)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

2-ethyl-hexenal  (26266-68-2)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

Dichloropropanol (26545-73-3)

EPACASR

     Source assessment;  continuing project
     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions
                                56

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Hydrocarbons, amylene  feed  debutanizer  overheads  nonextractable
raffinates  (68514-29-4)

EPACASR

     Episode report:   interim document  completed  April  1978

CHEMTRAX

No Entries  in" CHEMTRAX

2-chloro-l,3-butadiene (126-99-8)

EPACASR

     Exposure assessment; completed May 1980
     Preregulatory assessment; completed December 1979
     Source assessment; continuing project
     Technical assistance data; completed December 1977
     Section 8(a) regulation; proposed  February 29, 1980

CHEMTRAX

     ITC Master File
     ITC Phase I Score File
     ITC Phase II Score File
     ITC Phase III Score File
     TSCA section 8(a) actions
     TSCA section 8(d) actions
     Air Pollutants -  Clean Air Act
     NIOSH  Criteria Document Status
     OSHA TLV
     IARC Monographs
     NIOSH  Current Intelligence Bulletins
     Assessment Division Pre-CHIP Screenings
-    Fishbein List
     NTP Testing Chemicals
     Preliminary List  Chemicals

1,3,5-trioxane (110-88-3)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section-8(a) actions

2-methyl-3-butenenitrile (16529-56-9)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980
                                  57

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     CHEMTRAX

          TSCA section 8(a) actions

•    2-methyl-propanoic acid, monoester with 2,2,4-triinethyl-l,3-pentanediol
     (25265-77-4)

     EPACASR

          Section'8(a) regulation; proposed February  29, 1980

     CHEMTRAX

          TSCA section 8(a) actions

•    Methylbutene  (26760-64-5)

     EPACASR

          Section 8(a) regulation; proposed February  29, 1980

     CHEMTRAX

          TSCA section 8(a) actions

•    Naphtha (petroleum), light catalytic reformed, arom.-free  (68513-03-1)

     EPACASR

          Episode report; interim document completed April 1978

     CHEMTRAX

     No Entries for CHEMTRAX

•    Tetrachloroethane (25322-20-7)

     EPACASR

          Section 8(a) regulation; proposed February  29, 1980

     CHEMTRAX

          TSCA section 8(a) actions
          Static Acute Toxicity Testing

•    3-methyl-l-butene (563-45-1)

     EPACASR

          Section 8(a) regulation; proposed February  29, 1980
                                      58

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     CHEMTRAX

          TSCA section 8(a) actions
     -    Preliminary List Chemicals

•    Triethylbenzene (25340-18-5)

     EPACASR

          Technical assistance data; completed December 1977

     CHEMTRAX

     No Entries on CHEMTRAX

•    2-propenal (107-02-8)

     EPACASR

          Exposure assessment; completed May 1980
          Source assessment; continuing project
          Preregulatory assessment; completed December 1979
          Regulation promulgated under section 311 of CWA;
          August 29, 1979
          Interim episode report; completed April 1978
          Water quality criteria; proposed July 25, 1979
          Regulation promulgated under FIFRA; February 9,  1978
          Regulation promulgated under RCRA; May 19, 1980
          Technical assistance data; completed December 1979
          Technical assistance data; completed June 1975
          Summary review;  completed March 1978

     CHEMTRAX

          ITC Master File
          ITC Phase I Score File
          ITC Phase II Score File
          ITC Phase III Score File
     -    Chemical Hazard Information Profile (CHIP)
     -    Water Program's 65 Chemicals
          Static Acute Toxicity Testing
          Air Pollutants  - Clean Air Act
          Clean Water Act section 311 Chemicals
          OSHA TLV
     -    FIFRA chemicals
     -    IARC Monographs
          Assessment Division Pre-CHIP Screenings
          Water Pollution Control Federation
          Active Ingredients in Registered Pesticides
          Fishbein List
          NTP Testing Chemicals
          Preliminary List Chemicals
                                     59

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•    Trioctylaluminum  (1070-00-4)


     EPACASR


          Section 8 (a) regulation; proposed February 29,, 1980


     CHEMTRAX
   ,  -    TSCA section 8(a) actions
                   V

•    Trihexylaluminum (1116-73-0)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8 (a) actions


•    Tridodecylaluminum  (1529-59-5)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions


•    Tris(decyl)aluminum (1726-66-5)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX

          TSCA section 8(a) actions


•    2,5,8,ll,14-pentaoxahexadecan-16-ol  (23778-52-1)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions
                                      60

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 •    Dichloroacetaldehyde (79-02-7)



      EPACASR



           Section 8(a)  regulation; proposed February 29,  1980



      CHEMTRAX



   /  -     TSCA section  8 (a)  actions
                  V


 •    2-hydroxy-4-(methylthio)-butanoic acid (583-91-5)



      EPACASR



           Section 8(a)  regulation; proposed February 29,  1980



      CHEMTRAX



           TSCA section  8(a)  actions



 •    2,3,5,6-tetrachloro-l,4-benzenedicarbonyl  dichloride (719-32-4)



      EPACASR



           Section 8(a)  regulation; proposed February 29,  1980



      CHEMTRAX



           TSCA section  8 (a)  actions



 •    Tritetradecylaluminum  (1529-58-4)



      EPACASR



           Section 8(a)  regulation; proposed February 29,  1980



      CHEMTRAX



           TSCA section  8(a)  actions



 •     Trihexadecylaluminum (1726-65-4)


      EPACASR



           Section 8(a) regulation; proposed February 29,  1980



      CHEMTRAX



           TSCA section 8(a)  actions



•     Trioctadecylaluminum (3041-23-4)



      EPACASR



          Section 8(a) regulation? proposed February  29,  1980




       -                            61

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     CHEMTRAX


          TSCA section 8(a) actions


•    Butoxymethanol  (3085-35-6)


     EPACASR


   ,  -    Section 8(a) regulation; proposed February 29, 1980
                  *»'

     CHEMTRAX


          TSCA section 8(a) actions


•    1-octadecanol, sodium salt  (3985-81-7)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions


•    2-methylpentanedinitrile  (4553-62-2)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions


•    Propanoic acid, 2-methyl-, 2,2-dimethyl-l-(1-methylethyl)-1,3-
     propanediyl ester (6846-50-0)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions


•    Thiosulfuric acid, monoammonium salt  (10103-43-2)


     EPACASR


          Section 8(a) regulation; proposed February 29, 1980


     CHEMTRAX


          TSCA section 8(a) actions
                                     62

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1-octanol, aluminum salt  (14624-13-6)




EPACASR




     Section 8(a) regulation; proposed February  29,  1980




CHEMTRAX




     TSCA section 8(a) actions




1-dodecanol,aluminum salt  (14624-15-8)




EPACASR




     Section 8(a) regulation; proposed February  29,  1980




CHEMTRAX




     TSCA section 8(a) actions




2-hydroxy-4-(methylthio)-butanenitrile  (17773-41-0)




EPACASR




     Section 8(a) regulation; proposed February  29,  1980




CHEMTRAX




     TSCA section 8(a) actions




1-hexadecanol, aluminum salt  (19141-82-3)




EPACASR




     Section 8(a) regulation; proposed February  29,  1980




CHEMTRAX




     TSCA section 8(a) actions




1-hexanol, aluminum salt  (23275-26-5)




EPACASR




     Section 8(a) regulation; proposed February  29,  1980




CHEMTRAX




     TSCA section' 8(a) actions




1-decanol, aluminum salt  (26303-54-8)




EPACASR




     Section 8(a) regulation; proposed February  29,  1980





                               63

-------
CHEMTRAX

     TSCA section 8(a) actions

9-octadecenoic acid(Z)-, isooctyl ester  (26761-50-2)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

Cyclododecatriene (27070-59-3)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     ITC Phase III Score File
     TSCA section 8 (a) actions

-------
                              REGION VII
The nine chemical substances exclusively manufactured in Region VII between




10-50 million Ibs/yr were not under consideration for any regulatory action as




reported for the FRSS between January 1, 1978, and October 8, 1980, when the



search was completed.  No substances were exclusively produced in quantities




above the 10-50 million Ib/yr range.
                                     65

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                         REGION VII

Perchloric acid, ammonium salt (7790-98-9)

EPACASR

     Technical assistance data; completed December 1977
     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions

Sepiolite (61180-58-3)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions
                                 67

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                              REGION VIII
Two chemicals exclusively manufactured in Region VIII at or above 10-50 million




Ibs/yr are subject to the following notice and proposed rule.  Note that some




of the chemicals are listed  for more than one action.  Chemicals for each




action are listed below by their CAS number and CAS preferred names as they




appeared in the Federal Register.








Federal Register Notices








A.   45FR66506, October 7, 1980









     Notice; Environmental Protection Agency, Office of Pesticides and Toxic




     Substances, Toxic Substances Control Act








     Interagency Testing Committee, chemicals for review for possible testing




     recommendation under section 4 of TSCA.  Comment period closed January 5,




     1981.








     CAS #          CAS preferred Name








     12200-88-3     Vanadic  acid, hexasodium salt








B.   45FR13657, February 29, 1980








     Proposed rule; Revision of 40CFR712, Environmental Protection Agency,




     Office of Pesticides and Toxic Substances, Toxic Substances Control




     Act                             69

-------
Section 8(a) - proposed recordkeeping and reporting requirements.



CAS #          CAS Preferred Name



12200-88-3     Vanadic acid, hexasodium salt
            V
12161-82-9     Bertrandite
                                  70

-------
                         REGION VIII




Bertrandite  (12161-82-9)




EPACASR




     Section 8(a) regulation; proposed February 29, 1980




CHEMTRAX




     TSCA section 8(a) actions




Vanadic acid, hexasodium salt (12200-88-3)




EPACASR




     Section 8(a) regulation; proposed February 29, 1980




CHEMTRAX




     TSCA section 8(a) actions
                                 71

-------
                                    REGION IX
Five chemicals exclusively manufactured in Region IX at or above 10-50 million


Ibs/yr are subject to the proposed TSCA section 8(a) rule.  Chemicals for

                   V
each action are listed below by their CAS number and CAS preferred names as


they appeared in the Federal Register.




Federal Register Notice




A.   45FR13657, February 29, 1980




     Proposed rule; Revision of 40CFR712 Environmental Protection Agency,


     Office of Pesticides and Toxic Substances, Toxic Substances Control


     Act




     Section 8(a) - proposed recordkeeping and reporting requirements.
     CAS #
CAS Preferred Name
     69011-11-6     Sodium carbonate sulfate

     1330-43-4      Boric acid, disodium salt

     16349-83-0     Sulfuric acid, potassium sodium salt

     7790-98-9      Perchloric acid, ammonium salt

     61180-58-3     Sep'iolite
                                      73

-------
                          REGION IX




Sodium carbonate sulfate  (69011-11-6)




EPACASR




     Section 8 (a) regulation; proposed February 29, 1980




CHEMTRAX




     TSCA section 8(a) actions




Boric acid, disodium salt (1330-43-4)




EPACASR




     Section 8(a) regulation; proposed February 29, 1980




CHEMTRAX




     TSCA section 8(a) actions




Sulfuric acid, potassium sodium salt  (2:3:1)  (16349-83-0)




EPACASR




     Section 8(a) regulation; proposed February 29, 1980




CHEMTRAX




     TSCA section 8(a) actions
                                75

-------
                               REGION X
Two chemicals exclusively manufactured in Region X at or above 10-50 million




Ibs/yr are subject to the proposed TSCA section 8(a) rule.  Chemicals for




each action are listed below by their CAS number and CAS preferred names




as they appeared in the Federal Register.








Federal Register Notice








A.   45FR13657, February 29, 1980








     Proposed rule; Revison of 40CFR712 Environmental Protection Agency,




     Office of Pesticides and Toxic Substances, Toxic Substances Control




     Act








     Section 8(a)  - proposed recordkeeping and reporting requirements.








     CAS #          CAS Preferred Name








     7782-77-6      Nitrous Acid




     62010-10-0     Zirconium oxide sulfate
                                      77

-------
                          REGION X

Nitrous acid (7782-77-6)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX
             V
     TSCA section 8(a) actions
     Assessment Division Pre-CHIP Screenings

Zirconium oxide sulfate (62010-10-0)

EPACASR

     Section 8(a) regulation; proposed February 29, 1980

CHEMTRAX

     TSCA section 8(a) actions
                                  79

-------
                              APPENDIX A


                     DESCRIPTION OF CHEMTRAX FILES
*TSCA SEC. 8(a) ACTIONS—under section 8(a) EPA may require manufacturers,



processors, or distributors to maintain records and submit reports on
                V


certain chemical substances, mixtures, and categories of substances.



The type of information required may include chemical identification



use, manufacturer and adverse reactions to health or the environment.



Section 8(a) is expected to be particularly useful in defining categories



and determining the relative importance of category members.  CHEMTRAX



will also report the dates of rules promulgated with respect to the



reporting and retention of information under TSCA section 8(a) once the



proposed rule is finalized.






*ITC TESTING RECOMMENDATIONS—summarizes the recommendations in the ITC reports



to the EPA Administrator.  It is updated every 6 months as mandated by TSCA



section 4(e)_.  The recommendation reported in CHEMTRAX simply indicates the



type of test ITC has recommended.  Further testing may be recommended for the



following:  carcinogenicity, mutagenicity, teratogenicity, other chronic



effects, environmental effects, and epidemiology.






*TSCA SEC. 8(d)—under section 8(d), EPA may require persons who manufacture,



process, or distribute certain chemical substances and mixtures to submit



lists of health and safety studies.  The types of studies submitted under 8(d)



include those conducted or initiated by the submitter, known to that person,



or reasonably ascertainable by the person.  CHEMTRAX reports the dates of



rules promulgated with respect to the submission of lists of health and safety



studies and the types of studies submitted.
                                    81

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*WATER SEC. 311 CHEMICALS—prohibits the discharge of chemicals into the




navigable and coastal-shore waters of the U.S.  Two hundred ninety-nine chemicals




have been designated as hazardous to date.  These chemicals are considered




hazardous based on their acute toxicity to aquatic animals, aquatic flora,




and/or mammals.









The original regulation, promulgated 3/13/78, designated the chemicals in Data




Source 23 as hazardous.  This regulation was revoked on March 13, 1978.




Another regulation, as amended version of the first regulation, was proposed




on February 16, 1979 and promulgated on August 29, 1979.  This regulation




became effective on September 28, 1979.  Where a chemical has been proposed




for deletion from the list, this revocation date is given.  In some cases, the




proposed hazardous reportable quantity differs from the effective amount.




Differences between the old and new regulation can be ascertained from the




Federal Registers published on the forementioned dates.









*NTP TESTING—The National Toxicology Program encompasses a wide range of




toxicological testing being conducted throughout the Fesderal Government.




Participant agencies include NIEHS, FDA, Center for Disease Control, NIOSH,




and many subgroups of the National Institutes of Health.  CHEMTRAX lists the




testing schedule, the type of testing, and the agency conducting the test.
*These five files correspond to those files listed on Chart B (page 12).  The




 NTP Testing file described on this page includes the types of tests completed




 or in progress and thus the three NTP files on Chart B are incorporated into




 this one NTP Testing category.  The remainder of the CHEMTRAX files in




 Appendix A are listed alphabetically.




       —                              82

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                     Description of CHEMTRAX Files
ACTIVE INGREDIENTS IN REGISTERED PESTICIDES—lists chemical substances
                  V


registered with OPP/EPA as active ingredients in pesticides.








ACUTE TOXICITY TO AQUATIC ORGANISMS—historical list of chemical substances



for which there are LD50 data for fish and/or aquatic invertebrates.







AD PRE-CHIP SCREENING—the Assessment Division screens chemical information



from journal articles, current awareness activities, government reports, and



other sources.  For each chemical, a decision is made to continue or to



discontinue assessment.  Continuation of assessment can result in a number



of further activities, including preparation of a production/use profile



(PUP) or a CHIP, or toxicity verification.  When assessment is discontinued,



the rationale is given; i.e., low toxicity, low exposure, or regulation by



another office or agency.







AIR POLLUTANTS—reports on substances regulated under the Clean Air Act



which requires safe levels set or emissions restricted for certain substances.







ASSESSMENT DIVISION—CHEMICAL HAZARD INFORMATION PROFILES (CHIP)—refers



to chemicals for which CHIP Reports or Preliminary Chemical Profiles have



been selected or completed.  This assessment process begins with evaluation



of section 8(e)  notices, professional and trade journals, EPA, NCI, NIOSH, and



other agency publications to identify chemicals of potential concern and
                                      83

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applicability under TSCA.  Profile reports, which inclxide chemical charac-




teristics, production and use data, and health and environmental effects data,




are prepared within the Assessment Division.  Following a review seminar,




dispositions are assigned to these chemicals.  Possible* Assessment Division




actions range from referral to other agencies (CPSC, OSHA) or EPA offices,.




to continuation of the Assessment process with the. preparation of a more




detailed Phase I report.  These dispositions, as well as the status of profile




preparation, are reported in CHEMTRAX.








CAG CHEMICALS—represents those chemicals being reviewed by the Cancer




Assessment Group.  There are presently six defined decisions which can be




listed.  Both the dates of action/decision and the disposition are recorded.








FIFRA CHEMICALS—file is in the process of being deleted.








FISHBEIN LIST—lists organic compounds which are considered potential




industrial carcinogens or mutagens.  They were selected on the basis of their




reported carcinogenicity and/or mutagenicity, their relationships to known




carcinogens and mutagens, their volume or use characteristics, and suggested




or estimated potential populations at risk.








The purpose of the FISHBEIN study was to focus on the possible correlative




features, primarily structural, of a number of significant industrial chemicals




that have been reported in the literature to be carcinogenic and/or mutagenic.




This structural correlation could facilitate the prediction of potential




chemical hazards in the future, and the prioritization of existing potential




chemical carcinogens and mutagens for investigation in long-term animal studies.
                                      84

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The information  in  the data  source  includes  a  number  representing an  assigned



class  for each chemical.  This  is followed by  a series of  numbers,  either



0, 1,  2, or  3 corresponding  to  the  reported  reaction  of  the  chemical  in



several areas of mutagenic or carcinogenic testing.   (0) indicates that no



information  was  found on the chemical by  the literature  search  in that area?
  /                                                                       .
                 V

(1) indicates the chemical has  been reported positively  in that area;



(2) indicates the chemical was  shown negatively in that  area; and (3)  indicates



that information was found to support both positive and  negative results in



that area.







FOR YOUR INFORMATION—OTS frequently receives  new information  (or results of



studies) on  chemical substances from private industry.   Most of this  infor-



mation comes in  under TSCA section  8(e);  however, occasionally  it is  submitted



on an  informal "for your information" basis.   The Assessment Division evaluates



these  submissions in a status report, refers information to  potentially



interested EPA offices or government agencies,  and prepares  a followup letter



that is sent to  the submitter.  CHEMTRAX  lists relevant  dates and study



information.







HAZARDOUS WASTE  SITE CHEMICALS—this is a pointer data source listing chemicals



that have been identified at hazardous waste sites  (taken  from  tables in



the EPA report Damage and Threats Caused  by  Hazardous Materials Sites,  published



in 5/80 by the Oil and Special  Materials  Control Division  (EPA/430/9-9-/004)).



Although it  is only a partial compilation of damages and threats (from data



available during February and March 1980)  it includes damages caused  by



hazardous material migration covered in more than 350 site descriptions



including water contamination,  drinking water  well closures, fish kills,
                                      85

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property damage from fires and explosions, kidney disorders, cancer, and




death.  CHEMTRAX lists the names of the hazardous waste materials discussed




in this report.









IARC MONOGRAPH REVIEW—the International Agency for Research on Cancer  (IARC)




has developed a program to evaluate the carcinogenicity risk of chemicals




to humans.  In doing this, all relevant experimental and epidemiological




data about groups of chemicals for which there is known or possible human




exposure are collected and evaluated in terms of human risk.  International




working groups of experts in chemical carcinogenesis and related fields




conduct these* evaluations and the conclusions of these working groups are




published as a series of monographs.  The CHEMTRAX data source lists lARC's




conclusions, the volume number of the monograph, the production level for




each chemical reviewed, and results of tests (such as HP-human positive and




AS-animal suspected.)









IRLG REGULATORY DEVELOPMENT CHEMICALS—the Regulatory Workgroup of the IRLG




has taken on the responsibility for monitoring and reporting the development




of regulations on 20 selected chemicals at EPA, FDA, CPSC, and OSHA to foster




interagency coordination and awareness.









ITC MASTER LIST—contains all those chemicals perceived as potentially toxic




by the ITC and for which sufficient preliminary data were likely to be avail-




able for further selection and review of priority chemicals.  Originally




constructed by intersecting 19 existing lists of "significant chemicals," the




committee's Initial Listing of 3,649 chemical substances constitutes the




ITC MASTER LIST in CHEMTRAX.  The original source(s) naming each chemical is




(are) also referenced.




                                      86

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The Initial Listing was reduced by eliminating substances which had only




pesticide, food additive, or drug uses, and which were therefore subject to




regulation by Federal statutes other than TSCA.  In addition, chemicals which




were not commercially produced were dropped from further consideration and




scoring by ITC.  Of the chemicals not deleted on the preceding process, 770




were assigned scores on a number of factors relating to exposure and environ-




mental release.








ITC PHASE I SCORE FILE—this scoring was done in June 1977 and represents




specific baseline data for chemicals from which the ITC made the initial




determination that further detailed study and reviews were required.  The




relevant factors investigated in this phase, and which are also the data




variables from this source are:








     Number Exposed




     Exposure Frequency




     Exposure Intensity




     Penetrability




     Quantity Released




     Persistence




     Production Volume




     Occupational Exposure








Generally, the higher the score, the more pronounced the effect.  For an




explanation of scoring methodology and interpretation of results, see the




ITC's Initial Report to the Administrator (October 1977).
                                       87

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Based on the Phase I scores, chemicals were either deleted from consideration




or designated to the Preliminary List.  The Phase I Deletion and Deletion




Dispositions reflect decisions made in constructing the Preliminary List.









ITC PHASE II SCORE FILE—this scoring represents the second level of ITC's •




initial evaluation process whereby additional data was gathered about a chemical




substance.  The relevant biological scores gathered in this stage (Fall 1977),




which are also the data variables from this source are:









     Carcinogenicity




     Mutagenicity




     Teratogenicity




     Acute Toxicity




     Other Toxic Effects




     Ecological Effects




     Bioaccumulation




     Sum Numbered Scores (positive)




     Sum Lettered Scores (negative)




     Contaminants




     Human Exposure Index




     Environmental Exposure Index









Generally, scores ranging from 0.1 to 3.0 denote weak to strong evidence of




the effect.  A zero score means that negative results were found when tested.




Scores ranging from -0.1 to -3.0 denote weak to strong suspicion of the effect




(based on structure/activity, etc.).  For an explanation of scoring methodology




and interpretation of results,  see the ITC's Initial Report to the Administrator




(October 1977).





        _                              88

-------
The Biological activity scores were used  to establish the hazardous potential




of each chemical, and were considered together with the exposure indexes in




designating certain chemicals for more detailed review.  Following evaluation




of the Phase II scores, a Preliminary List classification  (Code Table 28) was




assigned.









ITC PHASE III SCORE FILE—the third round of scoring done by the ITC  (Fall 1978)




was based on the same methodology used in Phase I.  The factors scored were




the same as in earlier scoring  (see data  source 2).  CHEMTRAX variables are




summary scores for this round of exposure scoring:









     Equal weight - the average of the number exposed, frequency, intensity,




       penetrability, quantity released,  and persistence




     Human effects - the sum of the first four factors




     Environmental effects - the sum of the last four factors




     Production effects




     Occupational exposure









Generally, the higher the score, the more pronounced the effect.









ITC PHASE IV SCORES—the Phase IV scores  contain the results of biological




scoring done for the ITC in February of 1979.  The scoring methodology was




essentially the same as for the Phase II  scores.









NCI BIOASSAY CHEMICALS—consists of a list of chemicals that have been approved




for testing by NCI since July 1, 1977.  Actual selection for testing is based




on physical chemical properties, level of priority assigned, availability
                                      89

-------
and/or cost of the chemical, previous or concurrent testing elsewhere, etc.



The criteria for prioritization are the level of widespread exposure, relation



to known carcinogens, and results of previous tests or studies.  The information



available in CHEMTRAX on chemicals selected for testing includes status of the

                      f

study, route of administration, species, and results.
   j                                                                        ,






NIOSH CRITERIA DOCUMENT—NIOSH publishes Criteria Documents on specific chemical



substances.  These are comprehensive reports which are issued irregularly and



are intended to serve as the initial justification for regulatory action.



CHEMTRAX reports the stage of Criteria Document development as well as the



date they are transmitted to OSHA.







NIOSH CURRENT INTELLIGENCE BULLETINS—this system was (developed by NIOSH to



report new information on potential occupational hazards.  In addition to



reporting epidemiological and laboratory animal studies, standards for industrial



hygiene and exposure levels may be recommended.  The bulletins are usually



limited to a few pages in length and provide g^iick ove:rviews rather than in-depth



analyses.  The CHEMTRAX data source notes the Bulletin number and date of



any chemicals in the NIOSH system.







OSHA CARCINOGENS—this data source is a list of substances that have been



categorized in conjunction with the Occupational Safety and Health Adminis-



tration's proposed Generic Carcinogen policy for the identification, classi-



fication, and regulation of toxic substances posing a potential occupational



carcinogenic risk.
                                      90

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In putting together the list, three sources were used as the basis for an




elimination process.  This list represents those substances considered to be




carcinogens that are found in the American working place.  The chemicals listed




are limited to those that appeared on the NIOSH "Suspect Carcinogen" list,




and either the EPA TSCA Candidate List or the U.S. International Trade
   j



Commission's 1976 data base  (USITC).  The EPA list and USITC list were used




as they are fairly accurate  sources of chemicals found in the American work-




place.  The chemicals are divided into category 1, 2, or 3.  These are defined




below.








Category 1:    chemicals whose carcinogenic!ty, as defined, has been determined




               in humans, in two or more mammalian species of test animals, or




               in one species if the results were replicated.








Category 2:    chemicals whose carcinogenicity has been reported but the




               evidence is for some reason only suggestive, as defined, or




               positive in one species but not yet replicated.
Category 3:
those chemicals for which the evidence is inadequate to raise



any concern regarding carcinogenicity, or where the evidence



consists of animal data in a single species that is less than



suggestive.
PHASE I CHEMICALS—refers to chemicals for which "Phase I" reports have been



prepared with the Assessment Division subsequent to the reorganization and




formalization of its chemical assessment process in early 1978.  These reports




are more detailed than the CHIP reports and are usually accompanied by
                                     91

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contractor literature searches.  Preparation of an outline, drafts, and the


final Phase I report are handled by the Assessment Division, with review of the


draft report by the various officers of OTS.  The completed version of the


final report, which includes a discussion of the sources of exposure, is the
  /

decision document.  It is circulated to the Toxic Substances Priority Committee


members, who review it with their staffs.  The TSPC then determines a course


of action for the chemical.  The range of disposition options includes, among


others documented in the CHEMTRAX data files, "proceed to Phase II Report."






PHASE II CHEMICALS—refers to chemicals which are undergoing a more detailed


review  (at the "Phase II" level).  Both a detailed analysis of effects and a


paper discussing both TSCA control options and nonregulatory control options


are prepared.  Based on the hazards, problems, and options presented, a


Phase II investigation may lead to regulatory action by OTS.






PRELIMINARY LIST CHEMICAL—list of chemicals to be used by OPTS when identifying


substances for potential regulation.






RESOURCE CONSERVATION AND RECOVERY ACT (1976):  3001 Hazardous Waste—RCRA


provides "for the development of management plans and facilities for the


recovery of energy and other resources from discarded materials and for the


safe disposal of discarded materials and for the regulation of management of


hazardous waste."  Section 3001 of the act directs EPA to list hazardous solid


wastes which are subject to regulation.  Variables listed in the file are


Regulatory Determination (ex:  hazardous waste, discarded commercial chemical


product) and maximum concentration level.
                                      92

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SAFE DRINKING WATER ACT—this data source is a list of substances contained in




the National Primary and Secondary Drinking Water Regulations, promulgated in




accordance with the Safe Drinking Water Act  (SDWA).  These regulations cite




maximum contaminant levels for community water systems, monitoring and analytical




retirements to ensure compliance, and notification, and record-keeping of-




analytic and compliance data.








The data source contains a list of the substances regulated, the proposal,




promulgation and effective dates of regulation, and a description of the




regulation.  Two general types of regulations are described.








Primary regulations are devoted to constituents and properties directly affecting




the health of the consumer.  These take the form of either maximum contaminant




levels or monitoring guidelines for water treatment that list indicators of




industrial contaminants.  In a few cases, one chemical has been regulated with




both a maximum contaminant level and a contaminant indicator.








Secondary regulations deal with the aesthetic qualities of drinking water,




applying to contaminants that are not a health threat, but affect the taste,




odor or appearance of public drinking water.  These maximum contaminant levels




are not federally enforceable; the implementation of secondary drinking water




regulations is under the authority of the states.








The codes used in the data source to describe SDWA regulations are as follows:








(1)  Secondary Regulations:  Maximum Contaminant Level




(2)  Primary Regulations:    Maximum Contaminant Level - Trihalomethanes
                                      93

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 (3)  Primary Regulations:    Contaminant Indicators - Synthetic Organic Chemicals

 (4)  Primary Regulations:    Maximum Contaminant Levels - Inorganic Chemicals

 (5)  Primary Regulations:    Maximum Contaminant Levels - Organic Chemicals

 (6)  Primary Regulations:    Maximum Contaminant Level - Organic  (also Contaminant
   /
       Indicators - Synthetic Organic Chemicals)




SPECIAL PESTICIDES REVIEW DIVISION—EPA has developed a registration review

process in which the human and environmental risks posed by a pesticide are

weighed against the benefits of the pesticide to users and consumers.  The

process is called Rebuttable Presumption Against Registration (RPAR) and is

carried out in the Office of Special Pesticide Reviews (SPRD) of OPP.




In the first phase of the RPAR process ("pre-RPAR review") all significant

scientific information on potential hazards associated with the pesticide is

gathered, reviewed and summarized in a position document  (PD 1)  which is pub-

lished in the Federal Register and mailed to registrants and other interested

parties.  An RPAR is issued if the information indicates: that the pesticide

poses any of the following hazards:  1) acute toxicity to humans and domestic

animals or fish and wildlife after low exposure; 2) chronic toxicity, including

oncogenicity, mutagenicity, teratogenicity, fetotoxicity and other chronic or

delayed effects, and reduction in populations of nontarg-et or endangered

species; or 3) lack of emergency treatment.  Registered products containing

the pesticide may continue to be used after the RPAR is issued unless it is

canceled or suspended..




If the scientific information does not indicate that these hazards exist, the

pesticide is returned to the registration process.  If an RPAR is issued, the
                                      94

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Agency moves to the second phase, the rebuttal period.  The rebuttal period




("comment period") extends for 45 (or in some cases, to 105) days during which




registrants, user groups, environmental groups, and any other persons may send




the Agency data which either supports or refutes presumption of risk.  During




this rebuttal period, the agency also begins to look for information on the




benefits of the pesticide.  After an analysis of all comments, if the rebuttal




is judged to be successful, the pesticide is returned to the registration




process.








If the rebuttal is not successful, the Agency initiates a more detailed risk/




benefit assessment.  The benefits associated with each use and regulatory option




are then compared with corresponding risks.  If the risks appear to outweigh




the benefits, the Administrator may either propose to impose certain restrictions




on its use or to cancel a particular use of the pesticide.  If the Administrator




finds the benefits to outweigh the risks, he may propose to reregister the




pesticide.  On the date of the Administrator's final decision, these Notices




of Intent to Cancel (or to Register) appear in the Federal Register.








The OPSR also evaluates pesticides for which some or all uses have been




voluntarily canceled by the producer (via a notice in the Federal Register.




Often, however., RPAR or pre-RPAR review continues when only uses are dis-




continued .








CHEMTRAX indicates the current disposition of the pesticide within or following




the review process.  The dates of the first and final Federal Register notices
                                     95

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are given, as well as the closing date for rebuttal comments, and dates of




any voluntary cancellations of chemicals outside the RFAR process.  Until the




RPAR and risk analysis phases are complete, the CHEMTRAX "Date of PD 1" and




"Date of Final Decision of Administrator" entries represent approximate goals




set by OSPR.








STATIC ACUTE TOXICITY TESTING—this data source lists chemicals for which




static acute toxicity tests have been run.  ^CCQI  are referenced for several




species of aquatic organisms (fresh water algae, water flea, bluegills, salt




water algae, mysid shrimp, and sheepshead minnow).  CHEMTRAX lists only the




chemicals tested.








TSCA SEC. 8(c) ACTIONS—reports the dates of rules promulgated with respect to




the reporting and retention of information on adverse reactions to health or the




environment.








TSCA SEC. 8(e)—under Section 8(e), any person having information which reasonabl




supports the conclusion that a substance presents a substantial risk to health




or to the environment must immediately inform the EPA Administrator to that




effect.  Notices of Substantial Risk are directed to the Assessment Division




which coordinates review and action.  A status report on each 8(e) submission




is prepared indicating the nature of the submission and any follow-up actions




which are taken.  The data available in CHEMTRAX are:  type of study; dispo-




sitions; chemical company; date of notice received; date of OTS action; sub-




mission number; date"of status report, and information on follow-up actions.








WATER POLLUTION CONTROL FEDERATION—the WPCF review is a summary of acute and




chronic toxicity of inorganic and organic pollutants to freshwater fish.
                                      96

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WATER PROGRAM  (65 chemicals)—under the Clean Water Act,  (Section 304) EPA




is required to publish and periodically update water quality criteria.  In




compliance with this, EPA must publish criteria for 65 specified toxic




pollutants which state the maximum recommended concentrations consistent  •




with the protection of aquatic life and human health.  If a chemical




searched in CHEMTRAX is part of this group it will be noted.  The number




of chemicals listed in CHEMTRAX is greater than 65 because some of the




pollutants are groups, and in CHEMTRAX the group numbers are listed.
                                     97

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JEPORT DOCUMENTATION IMPORT HO. 2.
PAGE EPA 560/TIIS-81-005
.. Trtte and Subtitle
TSCA Chemicals in Commerce Inventory: Regional and Status
Perspectives
. Author**)
)aryl L. Kaufman, Bob Janney, Donn Viviani
, Performing Organization Nam* and Address
J.S. EPA
)ffice,of Toxics Integration (TS-777)
.01 "M" Street, SW
7ashington, B.C. 20460
. Sponsoring Organization Nam* and Address
ame as 9 above.
S. Recipient' • Accession No.
5. Raport Oat*
August 1981
6.
8. Performing Organization R*pt. No.
10. Project/Task/Work Untt No.
It. Contract(C) or Grant(G) No.
(O
(G)
13. Type of Raport & Period Covered
TIIS October 1980
14.
. Supplementary Notes
 Abstract (Limit: 200 words)

 sing  the CICIS Inventory it was  possible to determine which  chemical substances
ere produced exclusively in each of the 10 EPA regions.  Slightly less than 50%
f the inventory  is  region-specific.  Confidential Inventory  runs do not affect
 lis finding.  A  regulatory status of the top  440 high production volume
 lemicals (a production volume range of 10-50  million Ibs/yr  was selected as  a
 it-off point) was completed and  it appeared that only 95 specific chemical
ubstances were undergoing any sort of assessment, regulation development,
 : were already regulated.  Document will provide the regions guidance
 i their priority setting.
 Document Analysis a. Descriptors
 b. Identifiers/Open-Ended Term*
  Region-specific  chemicals
  CICIA Inventory
 c. COSATl Field/Group
Availability Statement
». Security Class (This Report)
20. Security Class (This Page)
21. No. of Pages
22. Price
ANSUZ39.lt)
                                      See Instruction* on Reverse
OPTIONAL n>RM 272 (4-77)
(Formerly NTIS-3S)
Department of Commerce

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