vxEPA
United States
Environmental Protection
Agency
Office of Pesticides
and Toxic Substances
Washington, DC 20460
EPA-560/TIIS-81-005
August 1981
Toxic Substances
TSCA Chemicals in
Commerce Inventory:
Regional and State
Perspectives
Toxics Integration Information
Series
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EPA-560/TIIS-81-005
TSCA Chemicals
in Commerce Inventory:
Regional and State Perspectives
Prepared by:
Daryl L. Kaufman
with assistance from:
Bob Janney
Donn Viviani
and
Jean Bellinger
Denny Daniels
Patricia Grim
Chris Harvey
Karen Richardson
United States
Environmental Protection Agency
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FOREWORD
The TSCA Chemicals In Commerce Inventory; Regional and State Perspectives
is designed to provide EPA Regional and State officials with a better
understanding of how the TSCA Inventory can be used to meet regional
needs. This particular study addresses those chemicals that were
reported for the 1977 TSCA Inventory (nonconfidential), but produced
exclusively in each of the ten EPA regions. Because the total number of
region-specific substances was so large, a cut-off production volume was
selected allowing us to highlight the high volume chemicals produced
solely in each region.
The report is divided into three parts. Part I briefly discusses the
Inventory, the cut-off production volume selected, limitations to
Inventory use, and provides a summary of the remainder of the report.
Part II provides the results of the Inventory computer runs and two
charts further illustrating these results. Part III contains a regulatory
analysis of the selected high production volume chemicals. This was
obtained by accessing various on-line data systems and cross-matching
these chemicals with other EPA chemical lists and regulatory documents.
An Appendix is included at the end of this report describing on-line
information sources listed in an in-house data file (CHEMTRAX).
This report can be used to help the states compile priority lists of
chemicals, identify major producers of state (or region) specific
chemicals, and to determine those chemical manufacturers having to
comply with chemical-specific regulations.
We hope you find this study valuable. Any request or comments you may
have can be directed to the Information and Analysis Staff at 202-382-2249.
Walter W. Kovalick, Jr.
Director
Integration Staff
iii
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CONTENTS
Executive Summary vii
Part I. Introduction 1
Part II. Results 5
CHART A: Total Number of Chemicals by State 9
CHART B: Regulatory Status of "Exclusive" Chemicals . . 12
Part III. Regulatory Status 15
Appendix A: Description of CHEMTRAX Files ... 81
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EXECUTIVE SUMMARY
This report was prepared by the Office of Toxics Integration using the
TSCA Chemicals in Commerce Inventory (TSCA Inventory) and other information
systems to identify those chemicals produced in only one EPA region.
The study is intended to display for EPA Headquarters, Regional, and
State decision-makers those chemicals which, in terms of production, are
unique to one region and/or state. Such chemicals may well be of greater
regional or local concern than national. Some of the major report
findings are:
o Almost one-half of the chemicals listed in the nonconfidential
TSCA Inventory is region—and/or state—unique (21,688 regionally
unique substances out of an approximate 43,000 reported for
the initial public Inventory). The calculated 21,688 figure
may be an overestimate due to the Inventory limitations discussed
in the introduction to this report.
o Of these 21,688 region unique substances, only 440 are produced
in quantities equal to, or exceeding, 10-50 million Ibs/yr
(the minimum quantity range used to define high production for
this report). This total may also be affected by the Inventory
limitations.
o Of the 440 substances used for this analysis very few are
presently regulated by the Federal Government. One hundred
and twenty-eight of these chemicals were found to have Federal
vii
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regulatory citations. All but five of these citations, however,
pertained to information gathering or testing activities,
usually in proposed rules. If the uses of these chemicals
were as regionally unique as their production, the states might
well be the potential leaders in any regulations focused on
these chemicals.
o With regard to the region-by-region analysis, Region II (New
York, New Jersey, Puerto Rico, and the Virgin Islands) has
the largest total of exclusively produced substances (8,430).
However, Region VI (Texas, Louisiana, Oklahoma, New Mexico,
and Arkansas) produces the largest number of chemicals at or
above the 10-50 million Ibs/yr production volume range.
(Because of the widespread use of petroleum and natural gas as
chemical feedstocks, the geographic profile of the chemical
industry parallels the geographic profile of petroleum and
natural gas sources in Region VI, and chemical processors in
Regions II and VI.)
o This study was conducted using the original, non-confidential
TSCA Inventory data on some 43,000 chemicals (at the •"•-. time
this automated data was obtained, the Inventory supplements
containing an additional 11,000 chemicals had not been
computerized). Slightly less than half of the chemicals on
the complete Inventory (public and confidential, including all
Inventory supplements) have some type of confidentiality
claim filed against them. Of particular relevance is the fact
that approximately 20% of the Inventory chemicals have
viii
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confidentiality claims associated with plant site reported for
them. When further analyzed to see what effect this would
have on the 440 high production volume chemicals surveyed in
this analysis, it appeared that confidentiality claims did not
alter the findings. Approximately 5% of the 440 chemical
substances have confidentiality claims filed against them of which
less than half of these claims indicate the chemical was produced
in more than one region. In these instances, the production
volumes were too low (most of the time less than 1,000 Ibs.
or no 1977 production data was reported) to make a significant
difference in the results discussed in this report.
ix
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PART I; INTRODUCTION
Under the authority of TSCA, most manufacturers, processors, and importers
of chemical substances are required to: (1) report the identity of each
chemical substance manufactured at each site or imported for a commercial
purpose; (2) estimate the amount imported or manufactured during calendar
year 1977; and C3) indicate whether the substance is manufactured and
used only within one site. This list of chemicals, called the TSCA
Chemicals in Commerce Inventory, presently contains over 55,000 chemical
entries; however, only 43,000 data entries were accessible when this
study was conducted. This report identifies chemicals produced exclusively
in each EPA region as reported in the nonconfidential files of the TSCA
Inventory, and examines the regulatory status of these substances using
the EPA Chemical Activities Status Report (EPACASR), Federal Register
Search System (FRSS)*, CHEMTRAX and other information sources.
Because of the large number of chemicals produced exclusively in each
region, the production volume range of 10-50 million Ibs/yr was chosen
as the cutoff for a more detailed analysis. (This production range
ensures that at least one chemical will be listed for each EPA region.)
Some 440 chemical substances were reported as produced "exclusively" at
or above 10 million Ibs/yr in the nonconfidential initial TSCA Inventory.
Chemicals exclusively produced at or above these volumes are analyzed in
this report for regulatory status, states in which produced, and possible
reasons why these chemicals are only produced in the state/region.
*0ne limitation of the FRSS is that it covers only regulatory actions
occurring since January 1, 1978; any regulation or announcement
issued before then is not included.
1
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Since the production data used in this report are based on the TSCA
Inventory, the limitations of the use of Inventory data must be acknowledged:
(1) Due to the confidentiality requirements of TSCA, (a) some of these
chemicals may be listed in the confidential Inventory for other
regions; or (b) chemicals not listed at all in the public Inventory
^
may be listed as region-unique in the confidential Inventory; and
Cc) the nonconfidential Inventory did not contain the complete
listing of 55,000 substances at the time of this analysis.
(2) Excluded are all mixtures, pesticides, food additives, drugs,
cosmetics, tobacco, and substances that have not been produced or
processed since 1974, or presently produced only in small quantities
for research and development purposes.
(3) The Inventory reporting requirements stipulate that volumes be
reported in "order of magnitude" ranges (I.e., less than 1,000 Ibs,
1,000 Ibs to 10,000 Ibs, 10,000 Ibs to 100,000 Ibs, etc.). This
inhibits estimation of production volumes. Also, the imprecise
definitions of classes of chemical substances can result in underestimation
of U.S. production of a specific chemical substance.
(4) The exclusion of small businesses from the final Inventory reporting
rules (chemicals were not required to be reported unless they were
produced at a plant site, (a) at which at least 30 percent of the
total output was a "Chemical and Allied" or "Petroleum Refining"
product, (b) which produced at least 1,000,000 pounds of chemicals
not excluded by TSCA, or (c) in quantities of at least 100,000 Ibs.
(See 42FR64572, December 23, 1977).
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The 440 "high-production" region-specific chemicals were cross-matched
with the second edition of the EPA Chemical Activities Status Report
(EPACASR) and EPA's CHEMTRAX data base. EPACASR is an interactive
chemical data base which contains the only comprehensive summary of all
major Agency activities on chemicals. Chemicals listed in EPACASR are
listed under the EPACASR heading in Part III of this report (p. 15) with
only very basic information, but additional detailed information, such
as the nature of a program office activity, reasons for undertaking the
action, and contact person can be obtained from the publication itself.
CHEMTRAX contains regulatory, assessment, and testing information on
chemicals of interest to the Office of Toxic Substances. The latter
system includes data files from such other Federal agencies as the
National Cancer Institute and the Occupational Safety and Health Admini-
stration. Appendix A provides a description of the files appearing in
the CHEMTRAX search for the 440 region-specific chemicals.*
The 440 chemicals were also compared with the EPA Carcinogen Assessment
Group's (GAG) list of 150 substances for which cancer assessments have
been prepared to determine if any of the region-specific chemicals were
included. (The sources of information used in selecting agents as
candidates for the list are of two types: chemicals which the Carcinogen
Assessment Group previously has evaluated and has determined pose a
potential human cancer risk; and chemicals, the carcinogenicity of which
*Because many CHEMTRAX files are not EPA-related, these entries do not appear
in the EPACASR. Conversely, there are some file types in EPACASR (e.g.,
technical assistance data)_ that are not contained in CHEMTRAX. Since the
closing date for EPACASR data submission was July 1980, it is possible that
a chemical with a CHEMTRAX entry (such as a preparation of a risk assessment)
may not have a similar EPACASR entry because the report was completed after
July 1980. CHEMTRAX files not included in PART III or in Appendix A, because
no exclusive chemical was reported for them, are available at EPA Headquarters.
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the GAG reviewed because one or more of three organizations — the
International Agency for Research on Cancer (IARC), the National Cancer
Institute Bioassay Program which has been reorganized into the National
Toxicology Program (NTP), and the Food and Drug Administration (FDA) of
the U.S. Department of Health and Human Services — had concluded that
f
these chemicals are potentially human carcinogens. Substances were
placed on the GAG list only if they had been demonstrated to induce
malignant tumors in one or more animal species or to induce benign
tumors that are generally recognized as early stages of malignancies,
and/or if positive epidemiologic studies indicated they were carcinogenic.
Although the GAG has determined that there is substantial evidence of
carcinogenicity for each chemical substance on the list, the data varies
to some extent with respect to the scope and quality of the studies.*)
The only chemical appearing on CAG's list was PCB, a substance reported
on the nonconfidential Inventory to be produced only in Region V.
The remainder of this paper is organized into two parts. Part II presents
the results section of the paper. Conclusions drawn from the computer
runs of the three data files mentioned above are summarized. Possible
reasons why chemicals are produced exclusively in a particular State are
listed, and potential implications of such state-specific production for
state and regional officials are mentioned.
Part III contains the results of the computer runs of the three data
files and is organized by region. The FRSS searches are presented first
(the Federal Register citation is given along with a brief description
of the announcement/action) followed by the EPACASR and CHEMTRAX data.
*July 14, 1980 preamble to GAG list.
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PART II; RESULTS
As can be seen on Chart A, approximately one-half of the nonconfidential
Inventory is region-specific. Four-hundred and forty (440) of these
regionally unique substances are produced in or above the 10-50 million
Ibs/yr range, the majority of which appear to be unregulated by the
Federal Government.* The Government may not be currently interested
in these chemicals.
EPA Region II states produce the most region-specific substances (8,430),
whereas Region VI produces the most in or above the 10-50 million Ibs/yr
range. The regulatory actions/announcements appearing in the FRSS
search that recurred most often were the TSCA Section 8(a) Proposed
Reporting Rules (February 29, 1980) and the list of chemicals recommended
by the TSCA Interagency Testing Committee (ITC) for priority consideration
for testing for adverse health and environmental effects under Section 4
of TSCA.
Certain factors may be the primary impetus for establishing plant sites
in a particular area. For example, of the total number of chemicals
produced exclusively in Region VI, the majority are located in Texas and
Louisiana, both situated on the Gulf of Mexico and near petroleum supplies.
Large cities having access to harbors or major transportation routes
*The Federal Register Search System (FRSS) was used to search for regulatory
citations. A number of reasons may explain this lack of activity, including
the possibility of a dearth of health effects information for these substances,
the Government may not be currently interested in these chemicals, or the
substances may be non-toxic. It is important to remember that the Inventory
is a compilation of chemicals in commerce, many of which are non-toxic.
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appeared to be the sites for chemical plants exclusively producing
substances in that region at or above 10-50 million Ibs/yr. For example,
of the 34 chemicals produced at or above 10-50 million Ibs/yr (see p.
9) exclusively in Region III, almost one-third were produced in Baltimore,
Maryland.
/
Various factors such as those listed below may be considered when selecting
plant locations:
o Proximity to waterways for manufacturing and transportation
purposes.
o Proximity to new material, such as petroleum, natural gas, or
to feedstock plants which can cut transportation and storage
costs.
o Proximity to major users (and buyers) of the product, which
can also cut transportation costs.
o Amenable tax laws.
Chart A (page 9) lists, by region and states, the number of chemical
substances produced "exclusively" within them. The total of these
chemicals in quantities at or above 10-50 million lbs;/yr for each region
may exceed the sum (in or above this production range) of the state
totals in each region. There are instances where the substance is
produced in one EPA region, but in more than one state in that region.
This is apparent from the data provided in Chart A. In both Regions IV
and VI, the sum of the states' total number of chemicals produced in or
above 10-50 million Ibs/yr is larger than the total number of individual
chemicals produced in the same production ranges for those regions.
Region IV exclusively produced 38 distinct chemicals, yet the summed
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state totals equal 39. Region VI exclusively produced 227 distinct
chemicals, whereas the summed state totals equal 236. The difference
between the totals in Region IV is one; in Region VI, nine. This indicates
that one chemical substance was produced in two states in Region IV and
as many as nine chemicals were produced in more than one state in Region ,
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VI. As was indicated on Chart A, these totals do not account for multiple
plant sites. If a substance was manufactured in two or more plants in
different cities, so long as they were all located within the same
state, the chemical counted as only one exclusively produced substance
for that state.
For the 440 high production chemicals there were 128 total FRSS chemical
citations on Chart B (see p. 12) but they pertain to only 95 specific
chemical substances. Although Regions I and VII, respectively, produce one
and nine "exclusive" chemicals at or above the 10-50 million Ibs/yr
range, no regulatory action was shown for any of them. A comparison of
the larger numbers of total region-specific chemicals with the number of
chemicals for which a regulation/announcement has been proposed shows
that very few substances are under any Federal regulatory consideration.
Thus, EPA regions and state governments will not have to be concerned
with existing regulatory requirements at this time. However, when
proposed TSCA section 8 (a) rules are promulgated, manufacturers will be
subject to those reporting and data submission requirements for those
chemicals cited in the proposed rule.
The majority (approximately 78 percent) of these chemicals (the 440
exclusively produced chemicals at or above 10-50 million Ibs/yr for all
regions) are unregulated and not under immediate consideration for
potential regulation by EPA and/or other Federal agencies.
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As this paper was developed, the significance of confidentiality claims
in the TSCA Inventory as it relates to this analysis was considered.
Substances for which the chemical identity was declared confidential are
not included in the confidential computer file. These chemical identities
remain in the non-computerized Master Inventory File and are accessible
j
only manually by EPA staff. The total number of claims related to chemical
identity, however, are less than 7% (2,000-3,000 chemicals) of the Inventory
run for this analysis (approximately 43,000 chemicals) and, therefore,
would appear not to drastically affect the findings discussed in this paper.
Information contained in the confidential computer file are confidentiality
claims for several other aspects of the chemical (:L,e., site-limited,
manufacturer identification number, production, corporation, import, but
not chemical identity). It was determined from this information that
only 22 of the 440 chemical substances have confidentiality claims reported
for them. Of the 22, only 9 proved to be no longer region-specific. That
is, some reporting aspect of these nine substances was claimed confidential
in at least one other region. This does not affect the results of this
study because all but one of these substances were produced in quantities
less than 10-50 million Ibs/yr in that other region according to the
confidential data. The remaining substance (of the nine), although
produced in more than one region, is not being considered for assessment
or regulation. The confidential claims for 13 of the 22 substances were
made by manufacturers located in the same regions in which the substances
were produced as r.eported for the public Inventory. Thus, these 13
substances can still be considered region-specific.
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CHART A: TOTAL NUMBERS OF CHEMICALS BY REGION AND STATE
Total Number of Exclusively *Total Number of Exclusively
Produced Substances (All Produced Substances In Or
Regions/States Production Volumes) Above 10-50 Million Lbs/Yr
Region I i 1,228 1
CT 463 0
MA 385 0
RI 324 0
NH 40 0
ME 21 1
VT 00
Region II 8,430 15
NJ
NY
PR
VI
4,419
4,250
12
1
5
5
5
0
Region III 2,484 34
PA 1,751 6
WV 365 7
DE 212 6
MD 153 13
VA 41 2
DC 10
Region IV 2,519 38
SC 792 2
NC 508 0
TN 292 11
KY 288 6
AL 269 7
GA 226 2
FL 140 6
MS 59 5
*Does not reflect multiple sites (i.e., same chemical produced in more than
one site). A chemical produced at more than one site in the same State
counts for only one substance.
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CHART A: TOTAL NUMBERS OF CHEMICALS BY REGION AND STATE (continued)
Total Number of Exclusively *Total Number of
Produced Substances (All Produced Substances In C
Regions/States Production Volumes) ___ Above 10-50 Million Lbs/
/
Region V ;
IL
OH
MI
WI
MN
IN
Region VI
TX
LA
OK
AR
NM
Region VII
MO
IA
KS
NE
Region VIII
CO
UT
MT
WY
ND
SD
Region IX
CA
NV
HI
AZ
GU
3,875
1,360
1,079
672
328
361
187
1,200
791
312
109
27
1
. 426
320
72
28
6
196
113
59
22
3
0
0
1,218
1,208
6
3
1
0
43
10
15
8
3
2
5
227
119
97
18
1
1
9
2
4
1
2
18
4
1
11
2
0
0
41
38
2
0
1
0
*See footnote on previous page.
10
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CHART A: TOTAL NUMBERS OF CHEMICALS BY REGION AND STATE (continued)
Total Number of Exclusively *Total Number of Exclusively
Produced Substances (All Produced Substances In Or
Regions/States Production Volumes) Above 10-50 Million Lbs/Yr
Region X : 112 14
OR 53 4
WA 45 6
ID 14 4
AK 00
TOTAL: 21,688 440
*See footnote on page 9.
Note that the sum of 440 equals the number of specific ("exclusive") chemicals
produced in the 10 regions. If the individual State totals were summed, a
result of 450 substances would be obtained. This latter figure includes those
chemicals produced in more than one State in a region.
There were some instances where a substance was produced in the 10-50 million
Ibs/yr range and in lesser quantities at other sites in the same State.
For this report, only those States which are the sites of plants producing
10-50 million Ibs/yr are included.
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CHART B: REGULATORY STATUS OF "EXCLUSIVE" CHEMICALS PRODUCED
IN OR ABOVE 10-50 MILLION POUNDS PER YEAR, BY REGION
AND ACTION/NOTICE
EPA Rule/Other
Citation (Date of
Federal Register)
/
Proposed TSCA*
Sec. 8(a) 2/29/80
1980 ITC List
10/7/80
Proposed TSCA
Sec. 8(d) 12/31/80
CWA Designated Hazard
Substance (sec. 311)
3/13/78
NTP 1979 Annual Plan
- Lifetime Bioassay
7/24/79
NTP 1979 Annual Plan
Salmonella Mutagen
Assay 7/24/79
NTP 1980 Annual Plan
- Test Chemical 2/8/80
Total No. of Specific
Chemicals*
REGIONS
I II III II Y. VI VII VIII
3 14 12 12 40 — 2
— 2 5 3 1 13 — 1
Total Chemi
IX JC for Each Ac
52 "90
25
1 3 1 —
— 3 16 12 13 42
5 2 95/128
'KEY+
TSCA Sec. 8(a);
ITC List:
TSCA Sec. 8(d);
Designated Hazardous
Substances:
Record maintenance and submissions of information on 2,300
chemicals to the Administrator.
The new chemical list selected for review by the Interagency
Testing Committee (members reprejsent other Federal agencies)
for possible future testing rules under section 4 of TSCA.
To date only two test rules have been proposed.
Health and safety study submissions to EPA as required by
TSCA.
Chemicals for which a hazardous discharge reporting level
was promulgated under section 311 of the Clean Water Act.
12
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National Toxicology Program Life time bioassay in process.
Lifetime Bioassay;
National Toxicology Program Chemicals for which an Ames Test will be conducted.
Salmonella Mutagenicity
Assay;
National Toxicology Chemicals for which health effects test will be
Prbgram Test Chemical; conducted.
*NOTE; The totals reflect the number of individual chemicals produced in that
region, some of which are listed for more than one action/notice.
See Appendix A for more detailed definitions.
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PART III
Regulatory/Assessment Status
of High-Volume, Region-Unique
Chemicals
FRSS entries and EPACASR/CHEMTRAX entries are listed on separate
pages, but are located sequentially .(FRSS entries appear first) for
each region.
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REGION I
The one chemical substance, thermal hydrolyzed starch, (CAS# 68909-00-2)
exclusively manufactured in Region I between 10-50 million Ibs/year was not
under consideration for any regulation as reported for the FRSS between
January 1, 1978, and October 8, 1980, when the search was completed. There were
no chemical substances exclusively produced above the 10-50 million Ibs/year
range.
17
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REGION I
No entries in EPACASR or CHEMTRAX.
19
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REGION II
Three chemicals exclusively manufactured in Region II at or above 10-50 Ibs/yr
are subject to the following ITC notice and proposed TSCA section 8(a) rule.
/
Note that two of these substances are listed for both actions. Chemicals for
each action are listed below by their CAS number and CAS preferred name as they
appeared in the Federal Register.
Federal Register Notices
A. 45FR66506, October 7, 1980
Notice: Environmental Protection Agency, Office of Pesticides and Toxic
Substances, Toxic Substances Control Act.
Interagency Testing Committee; chemicals for review for possible testing
recommendation under section 4 of TSCA. Comment period closed January 5,
1981.
CAS # CAS Preferred Name
95-49-8 l-Chloro-2-methyl benzene
5216-25-1 l-Chloro-4-(trichloromethyl) benzene
21
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B. 45FR13657, February 29, 1980
Proposed rule; Revision of 40CFR712, Environmental Protection Agency,
Office of Pesticides and Toxic Substances, Toxic Substances Control Act
/
V
Section 8(a) - proposed recordkeeping and reporting requirements.
CAS # CAS Preferred Name
95-49-8 l-Chloro-2-methyl benzene
5216-25-1 l-Chloro-4-(trichloromethyl) benzene
68797-39-7 l(or 3)-(carboxymethyl)-4,5-Dihydro-l-(2-
Hydroxyethyl)-2-undecyl-, salt with .alpha.-
sulfo-.omega.-(tridecyloxy)poly(oxy-1,2-
ethanediyl) lH-Imidazolum,monosodiuiri salt
22
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REGION II
l-chloro-2-methyl benzene (95-49-8)
EPACASR
- Analytical Methods Development; completed March 1980
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
l-chloro-4-(trichloromethyl)-benzene (5216-25-1)
EPACASR
Analytical methods development; completion date March 1982
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA setion 8(a) actions
1(or 3)-(Carboxymethyl)-4,5-dihydro-l-(2-hydroxyethyl)-2-undecyl-
iN-imidazolium salt (68797-39-7)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
23
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REGION III
Sixteen chemicals exclusively manufactured in Region III at or above 10-50
million Ibs/yr are subject to the following notices and proposed and final-
regulations. Note that some of these substances are listed for more than one
action. Chemicals are listed below for each action by their CAS number and
CAS preferred name as they appeared in the Federal Register.
Federal Register Notices
A. 45FR66506, October 7, 1980
Notice; Environmental Protection Agency, Office of- Pesticides and Toxic
Substances, Toxic Substances Control Act
Interagency Testing Committee; chemicals for review for possible testing
recommendation under section 4 of TSCA. Comment period closed January 5,
1981.
CAS ft
CAS Preferred Name
563-47-3 3-Chloro-2-methylpropene
13414-54-3 1- (2-methyl-2-propenyl)oxy -2-nitrobenzene
13414-55-6 2,3-Dihydro-2,2-dimethyl-7-nitro-benzofuran
36452-21-8 1,3,5-Triazine-2,4,6(lH,3H,5H)-trione, disodium salt
68298-46-4 2,3-Dihydro-2,2-dimethyl-7-benzofuranamine
25
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B. 45FR13657, February 29, 1980
Proposed rule; Revision of 40CFR712, Environmental Protection Agency,
Office of Pesticides and Toxic Substances, Toxic Substances Control Act
/
Section 8(a) - proposed recordkeeping and reporting requirements.
CAS #
CAS Preferred Name
13414-58-9 2-(2-methylalkyl)-6-nitro-phenol
2027-17-0 2-(1-methylethyl)-naphthalene
95-08-9 2-ethyl- ,1, 2-ethanediylbis (oxy-2, l--ethanediyl
ester)butanoic acid
1563-38-8 2,3-dihydro-2,2-dimethyl-7-benzofuranol
12013-15-9 Copper hydroxide sulfate
13188-60-8 Dodecanedioic acid, cmpnd. with 1,6-hexanediamine (1:1)
13414-54-5 1- (2-methyl-2-propenyl)oxy -2-nitrobenzene
13414-55-6 2,3-Dihydro-2,2-dimethyl-7-nitrobenzofuran
22527-63-5 3-Hydroxy-2,2,4-trimethylpentyl ester benzoate
(isobutyric acid)
25339-56-4 Heptene
36452-21-8 1,3,5-Triazine-2,4,6(lH,3H,5H)-trione, disodium salt
37292-80-1 Silicic acid, calcium iron magnesium salt
68298-46-4 2,3-Dihydro-2,2-dimethyl-7-benzofuranamine
68411-80-3 1,3-Isobenzofurandione, oxidized
26
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C. 44FR43433, July 24, 1979
Notice; Public Health Service, National Toxicology Program (1979
Annual Plan). Lifetime bioassay in progress.
/
CAS ft ""' CAS Preferred Name
563-47-3 3-Chloro-2-methylpropene
D. 45FR8902, February 2, 1980
Notice; Public Health Service, National Toxicology Program (1980
Annual Plan). Test Chemical.
CAS # CAS Preferred Name
563-47-3 3-Chloro-2-methylpropene
27
-------
REGION III
2-(2-methylallyl)-6-nitrophenol (13414-58-9)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
2-(l-methyethyl}-naphthalene (2027-17-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
- TSCA section 8(a) actions
2-ethyl-, 1,2-ethanediylbis (oxy-2,1—ethanediyl)ester, butanoic
acid (95-08-9)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
3-chloro-2-methyl propene (563-47-3)
EPACASR
No entries in EPACASR
CHEMTRAX
ITC Master File
- ITC Phase I Score File
ITC Phase II Score File
ITC Phase III Score File
ITC Phase IV Score File
NCI Bioassay Chemicals
Preliminary List Chemicals
2,3-dihydro-2,2-dimethyl-7-benzofuranol (1563-38-8)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
29
-------
CHEMTRAX
TSCA section 8(a) actions
• Copper hydroxide sulfate (12013-15-9)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
/
CHEMTRAX
- TSCA section 8(a) actions
• Dodecanedioic acid, compound with 1,6-hexanediamine (1:1) (13188-60-8)
EPACASR
- Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
- TSCA section 8(a) actions
• 1- (2-methyl-2-propenyl)oxy -2-nitrobenzene (13414-54-5)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• 2,3-dihydro-2,2-dimethyl-7-nitrobenzofuran (13414-55-6)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• 3-hydroxy-2,2,4-trimethylpentyl ester benzoate isobutyric acid
(22527-63-5)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
30
-------
• Heptene (25339-56-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• l,3,5-triazine-2,4,6(lH,3H,5H)-trione, disodium salt (36452-21-8)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
- TSCA section 8(a) actions
• Silicic acid, calcium iron magnesium salt (37292-80-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• 2,3-dihydro-2,2-dimethyl-7-benzofuranamine (68298-46-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
- TSCA section 8(a) actions
• 1,3-isobenzofurandione, oxidized (68411-80-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Isopropylated phosphate phenol (3:1) (68937-41-7)
EPACASR
No entries for EPACASR
— 31
-------
CHEMTRAX
TSCA section 8(e) actions
32
-------
REGION IV
Twelve chemicals exclusively manufactured in Region IV at or above
10-50 million Ibs/yr are subject to the following notice and proposed and .
*
final regulations. Note that some of the chemicals are listed for more than
one action. Chemicals for each action are listed below by their CAS number
and CAS preferred name as they appeared in the Federal Register.
Federal Register Notices
A. 45FR66506, October 7, 1980
Notice; Environmental Protection Agency/ Office of Pesticides and
Toxic Substances, Toxic Substances Control Act
Interagency Testing Committee; chemicals for review for possible testing
recommendation under section 4 of TSCA. Comment period closed January 5,
1981.
CAS # CAS Preferred Name
1772-25-4 1,3,6-Hexanetricarbonitrile
2431-50-7 2,3,4-Trichloro-l-butene
63494-59-7 2- ethyl(3-methyl-4-nitrosophenyl)amino -
.N—nethyl-ethanesulfonamide
33
-------
B. 45FR13657, February 29, 1980
Proposed rule; Revision of 40CFR712, Environmental Protection Agency,
Office of Pesticides and Toxic Substances, Toxic Substances Control
Act.
*
Section 8(a)-proposed recordkeeping and reporting requirements.
CAS # CAS Preferred Name
106-31-0 Butanoic acid, anhydride
12789-64-9 Iron titanium oxide
13918-37-1 Fayalite
22708-90-3 Silicic acid, aluminum salt (1:2)
123-62-6 Propanoic acid, anhydride
121-45-9 Phosphorous acid, trimethyl ester
3982-91-0 Thiophosphoryl chloride
111-91-1 1,l'-methylenebis(oxy) bis 2-chloroethane
1772-25-4 1,3,6-Hexanetricarbonitrile
2431-50-7 2,3,4-Trichloro-l-butene
15075-85-1 9-Octadecene-l-sulfonic acid, sodium salt (Z)
63494-59-7 2- ethyl(3-methy1-4-nitrosophenyl)amino -
N-methy1-ethanesulfonamide
C. 43FR10485, March 13, 1978
Final rule; Environmental Protection Agency, Clean Water Act
Section 311 - Designated hazardous substance.
34
-------
CAS # CAS Preferred Name
123-62-6 Propanoic acid, anhydride
35
-------
REGION IV
Butanoic acid, anhydride (106-31-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Iron titanium oxide (12789-64-9)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Fayalite (13918-37-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Silicic acid, aluminum salt (1:2) (22708-90-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Propionic anhydride (123-62-6)
EPACASR
Technical assistance data; completed December 1977
Regulation promulgated under Clean Water Act; August 29, 1979
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
- Clean Water Act, section 311 chemicals
3,7
-------
Phosphorous acid, trimethyl ester (121-45-9)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
TSCA section 8(e) actions
- Assessment Division Chemical Hazard Information Profile (CHIP)
Thiophosphoryl chloride (3982-91-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
l,l,l-methylenebis(oxy) bis 2-chloroethane (111-91-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
Regulation promulgated under RCRA; May 19, 1980
CHEMTRAX
ITC Master File
- ITC Phase I Score File
ITC Phase II Score File
ITC Phase III Score File
- TSCA section 8(a) actions
Water program's 65 chemicals
- RCRA Section 3001 - Hazardous Waste
- Assessment Division Pre-CHIP Screenings
- Preliminary List Chemicals
1,3,6-hexanetricarbonitrile (1772-25-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
38
-------
• 2,3,4-trichloro-l-butene (2431-50-7)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
For your, information (see Appendix A for description)
• (z)-9-octadecene-l-sulfonic acid, sodium salt (15075-85-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• 2- ethyl(3-methyl-4-nitrosophenyl)amino -N-methyl-ethane sulfonamide
(63494-59-7)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
39
-------
REGION V
Twelve chemicals exclusively manufactured in Region V at or above 10-50
million Ibs/yr are subject to the following notice and proposed and final
/ -
rules. Note that some of the chemicals are listed for more than one action.
Chemicals for each action are listed below by their CAS number and CAS
preferred name as they appeared in the Federal Register.
Federal Register Notices
A. 45FR66506, October 7, 1980
Notice; Environmental Protection Agency, Office of Pesticides and
Toxic Substances, Toxic Substances Control Act
Interagency Testing Committee; chemicals for review for possible testing
recommendation under section 4 of TSCA. Comment period closed January 5,
1981.
CAS # CAS Preferred Name
594-42-3 Trichloromethanesulfenyl chloride
41
-------
B. 45FR13657, February 29, 1980
Proposed rule; Revision of 40CFR712, Environmental Protection
Agency, Office of Pesticides and Toxic Substances, Toxic Substances
, Control Act
Section 8(a)-proposed recordkeeping and reporting requirements.
CAS #
CAS Preferred Name
76-08-4 1,1,l-Tribromo-2-methyl-2-propanol
39445-23-3 Calcium magnesium hydroxide
58398-71-3 Calcium magnesium hydroxide oxide
10257-55-3 Sulfurous acid, calcium salt (1:1)
75-99-0 2,2-Dichloropropanoic acid
133-06-2 !H-Isoindole-l,3(2H)-dione, 3a,4,7,7a-
tetrahydro-2-((trichloromethyl)thio)
594-42-3 Trichloromethanesulfenyl chloride
1121-70-6 4-Methyl-phenol, sodium salt
7790-92-3 Hypochlorous acid
13780-17-1 Phosphoric acid, calcium sodium salt (1:1:1)
25167-81-1 Dichlorophenol
67923-88-0 Ethyl-9,10-dihydro-9,10-anthracenediol
C. 43FR10485, March 13, 1978
Final rule, Environmental Protection Agency, Clean Water Act
Section 311-Designated hazardous substance.
42
-------
CAS # CAS Preferred Name
1336-36-3 PCB's
75-99-0 2,2-Dichloropropanoic acid
133-06-2 ,. Captan
43
-------
REGION V
1,1rl-tribromo-2-methyl-2-propanol (76-08-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Calcium magnesium hydroxide (39445-23-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Calcium magnesium hydroxide oxide (58398-71-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Sulfurous acid, calcium salt (1:1) (10257-55-3)
EPACASR
Control technology development; completed April 1979
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
l,l'-biphenyl, chloro. derivs. (1336-36-3)
EPACASR
Analytical, methods development; completed August 1979
Exposure assessment; completed May 1980
Water quality criteria; completed November 1980
Technical assistance data; completed December 1977
Activities summary under TSCA; completed May 1979
Substitutes assessment; completed May 1979
45
-------
Preregulatory assessment; completed December 1979; another is in
progress
Preregulatory assessment; completed March 1979
Regulation promulgated under section 307(a) of the CWA;
February 2, 1977
Regulation promulgated under section 311 of the CWA; August 29, 1979
Regulation promulgated under FIFRA; October 29, 1970 .
Regulation promulgated under TSCA; February 17, 1978
Documentation/monitoring; completed June 1980
Documentation/monitoring; completed August 1979
Documentation/monitoring; completed September 1979
Control technology development; draft completed February 1980
Control technology development; completed July 1979
CHEMTRAX
ITC Master File
ITC Phase I File
TSCA section 8(a) actions
TSCA section 8(e) actions
CAG Chemicals
IRLG Regulatory Development Chemicals
Water section 311 chemicals
IARC Monographs
- Water Pollution Control Federation
NTP Testing Chemicals
- Hazardous Waste Site Chemicals
• 2,2-dichloro-propanoic acid (75-99-0)
EPACASR
Source assessment; continuing project
Regulation promulgated under section 311 of the CWA; August 29, 1979
- Technical assistance data; completed June 1975
- Section 8(a) regulation; proposed February 29, 1980
- Technical assistance data; completed December 1977
CHEMTRAX
ITC Master File
TSCA section 8(a) actions
Clean Water Act, section 311 chemicals
Active Ingredient in Registered Pesticides
Acute Toxicity to Aquatic Organisms
• 3a,4,7,7a-tetrahydro-2-((trichloromethyl)thio)-iH-isoindole-
l,3(2H)-dione (133-06-2)
EPACASR
Source assessment; completed July 1978
Regulation promulgated under section 311 of. CWA; August 29, 1980
46
-------
Documentation/monitoring; completion date August 1983
Documentation/monitoring; completed October 1977
Documentation/monitoring; completion date June 1983
Risk Assessment; completed January 1980
Technical assistance data; completed December 1977
Technical assistance data; completed June 1975
- Preregulatory assessment; completed October 1980
TSCA section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
ITC Master File
ITC Phase III Score File
TSCA section 8(a) actions
- Water section 311 chemicals
NCI Bioassay Chemicals
Assessment Division Pre-CHIP Screenings
RPAR Chemicals (Special Pesticides Review Division)
Active Ingredients in Registered Pesticides
Acute Toxicity to Aquatic Organisms
NTP Testing Chemicals
OSHA Carcinogens
Trichloromethanesulfenyl chloride (594-42-3)
EPACASR
Technical assistance data; completed December 1977
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
4-methyl-phenol, sodium salt (1121-70-6)
EPACASR
- Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
- TSCA section 8(a) actions
Hypochlorous acid (7790-92-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
Documentation/monitoring; completed July 1979
- Technical assistance data; completed December 1977
CHEMTRAX
TSCA section 8(a) actions
— 47
-------
• Phosphoric acid, calcium sodium salt (1:1:1) (13780-17-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
, - TSCA section 8(a) actions
V
• Dichlorophenol (25167-81-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
Summary review; completed December 1979
CHEMTRAX
TSCA section 8(a) actions
• Phosphorous acid, pentadecasodium salt (62533-93-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Ethyl-9,10-dihydro-9,10-anthracenediol (67923-88-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
48
-------
REGION VI
Forty-two chemicals exclusively manufactured in Region VI at or above
10-50 million Ibs/yr are subject to the following notices and proposed and
/
\-
final rules. Note that some of the chemicals are listed for more than
one action. Chemicals for each action are listed below by their CAS
number and CAS preferred name as they appeared in the Federal Register.
Federal Register Notices
A. 45FR66506, October 7, 1980
Notice; Environmental Protection Agency, Office of Pesticides and Toxic
Substances, Toxic Substances Control Act
Interagency Testing Committee; chemicals for review for possible
testing recommendation under section 4 of TSCA. Comment period closed
January 5, 1981.
CAS #
CAS Preferred Name
25340-18-5 Triethylbenzene
79-02-7 Dichloroacetaldehyde
719-32-4 2,3,5,6-Tetrachloro-l,4-benzenedicarbonyl dichloride
4553-62-2 2-Methyl-pentanedinitrile
17773-41-0 2-Hydroxy-4-(methylthio)-butanenitrile
49
-------
760-23-6 3,4-Dichloro-l-butene
75-34-3 1,1-Dichloroethane
13042-02-9 2-Hexenedinitrile
4635-87-4 3-Pentenenitrile
26545-73-3 Dichloropropanol
110-88-3 " 1,3,5-Trioxane
16529-56-9 2-Methyl-3-butenenitrile
25322-20-7 Tetrachloroethane
B. 45FR13657, February 29, 1980
Proposed rule; Revision of 40CFR712, Environmental Protection Agency,
Office of Pesticides and Toxic Substances, Toxic Substances Control
Act
Section 8(a)-proposed recordkeeping and reporting requirements.
CAS #
CAS Preferred Name
3071-32-7 1-Phenylethyl hydroperoxide
760-23-6 3,4-Dichloro-l-butene
75-34-3 1,1-Dichloroethane
13042-02-9 2-Hexenedinitrile
110-57-6 l,4-Dichloro-2-butene
4635-87-4 • 3-Pentenenitrile
26266-68-2 2-Ethyl-hexenal
26545-73-3 Dichloropropanol
50
-------
126-99-8 2-Chloro-l,3-butadiene
110-88-3 1,3,5-Trioxane
16529-56-9 2-Methyl-3-butenenitrile
25265-77-4 2-Methyl-propanoic acid, monoester with
2,2,4-trimethyl-1,3-pentanediol
26760-64-5 Methylbutene
25322-20-7 Tetrachloroethane
563-45-1 3-Methyl-l-butene
1070-00-4 Trioctyl aluminum
1116-73-0 Trihexyl aluminum
1529-59-5 Tridodecyl aluminum
1726-66-5 Tris(decyl)aluminum
23778-52-1 2,5,8,11,14-Pentaoxahexadecan-16-ol
79-02-7 Dichloroacetaldehyde
107-89-1 3-Hydroxy-butanol
583-91-5 2-Hydroxy-4-(methylthio)-butanoic acid
719-32-4 2,3,5,6-Tetrachloro-l,4-benzenedicarbonyl dichloride
1529-58-4 • Tritetradecyl aluminum
1726-65-4 Trihexadecyl aluminum
3041-23-4 Trioctadecyl aluminum
3085-35-6 Butoxymethanol
3985-81-7 1-Octadecanol, aluminum salt
4553-62-2 2-Methyl-pentanedinitrile
6846-50-0 2-Methyl-propanoic acid, 2,2-dimethyl-l-
(1-methylethyl-l,3-propanediyl ester)
10103-43-2 Thiosulfuric acid, monoammonium salt
14624-15-8 1-Dodecanol, aluminum salt
17773-41-0 2-Hydroxy-4-(methylthio)-butanenitrile
51
-------
19141-82-3 1-Hexadecanol, aluminum salt
23275-26-5 1-Hexanol, aluminum salt
26303-54-8 1-Decanol, aluminum salt
26761-50-2 9-Octadecenoic acid (2)-,isooctyl ester
27070-59-3 Cyclododecatriene
/
V
14624-13-6 1-Octanol, aluminum salt
C. 44FR77477, December 31, 1979
Proposed rule; Environmental Protection Agency, Office of Pesticides
and Toxic Substances, Toxic Substances Control Act
Section 8(d) - proposed health and safety studies submissions.
CAS # CAS Preferred Name
75-34-3 1,2-Dichloroethane
126-99-8 2-Chloro-l,3-butadiene
D. 43FR10485, March 13, 1978
Final rule, Environmental Protection Agency, Clean Water Act
Section 311 - Designated hazardous substance.
CAS # CAS Preferred Name
107-02-8 Acrolein
52
-------
E. 44FR43431, July 24, 1979
Notice; Public Health Service, National Toxicology Program (1979
Annual Plan). Salmonella mutagenicity assay.
•e
CAS # * CAS Preferred Name
126-99-8 2-Chloro-l,3-butadiene
107-02-8 Acrolein
F. 45FR8902, February 2, 1980
Notice; Public Health Service, National Toxicology Program (1980
Annual Plan). Test Chemical
CAS # CAS Preferred Name
107-02-8 Acrolein
126-99-8 2-Chloro-l,3-butadiene
53
-------
REGION VI
Number 2 Burner Fuel (68476-30-2)
EPACASR
No Entries for EPACASR
CHEMTRAX
V
TSCA section 8(e) actions
1-phenylethyl hydroperoxide (3071-32-7)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
3,4-dichloro-l-butene (760-23-6)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
1,1-dichlorpethane (75-34-3)
EPACASR
Regulation promulgated under RCRA; May 19, 1980
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
ITC Master File
ITC Phase I Score File
TSCA section 8(a) actions
TSCA section 8(e) actions
- Water Program's 65 Chemicals
RCRA Section 3001 - Hazardous Waste
Safe Drinking Water Act
OSHA TLV
2-hexenedinitrile (13042-02-9)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
^ 55
-------
CHEMTRAX
TSCA section 8(a) actions
l,4-dichloro-2-butene (110-57-6)
EPACASR
Regulation promulgated under RCRA; May 19, 1980
Sectionv8(a) regulation; proposed February 29, 1980
CHEMTRAX
- ITC Master File
ITC Phase I Score File
ITC Phase II Score File
TSCA section 8(a) actions
Preliminary List Chemicals
3-Pentenenitrile (4635-87-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
2-ethyl-hexenal (26266-68-2)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Dichloropropanol (26545-73-3)
EPACASR
Source assessment; continuing project
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
56
-------
Hydrocarbons, amylene feed debutanizer overheads nonextractable
raffinates (68514-29-4)
EPACASR
Episode report: interim document completed April 1978
CHEMTRAX
No Entries in" CHEMTRAX
2-chloro-l,3-butadiene (126-99-8)
EPACASR
Exposure assessment; completed May 1980
Preregulatory assessment; completed December 1979
Source assessment; continuing project
Technical assistance data; completed December 1977
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
ITC Master File
ITC Phase I Score File
ITC Phase II Score File
ITC Phase III Score File
TSCA section 8(a) actions
TSCA section 8(d) actions
Air Pollutants - Clean Air Act
NIOSH Criteria Document Status
OSHA TLV
IARC Monographs
NIOSH Current Intelligence Bulletins
Assessment Division Pre-CHIP Screenings
- Fishbein List
NTP Testing Chemicals
Preliminary List Chemicals
1,3,5-trioxane (110-88-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section-8(a) actions
2-methyl-3-butenenitrile (16529-56-9)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
57
-------
CHEMTRAX
TSCA section 8(a) actions
• 2-methyl-propanoic acid, monoester with 2,2,4-triinethyl-l,3-pentanediol
(25265-77-4)
EPACASR
Section'8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Methylbutene (26760-64-5)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Naphtha (petroleum), light catalytic reformed, arom.-free (68513-03-1)
EPACASR
Episode report; interim document completed April 1978
CHEMTRAX
No Entries for CHEMTRAX
• Tetrachloroethane (25322-20-7)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Static Acute Toxicity Testing
• 3-methyl-l-butene (563-45-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
58
-------
CHEMTRAX
TSCA section 8(a) actions
- Preliminary List Chemicals
• Triethylbenzene (25340-18-5)
EPACASR
Technical assistance data; completed December 1977
CHEMTRAX
No Entries on CHEMTRAX
• 2-propenal (107-02-8)
EPACASR
Exposure assessment; completed May 1980
Source assessment; continuing project
Preregulatory assessment; completed December 1979
Regulation promulgated under section 311 of CWA;
August 29, 1979
Interim episode report; completed April 1978
Water quality criteria; proposed July 25, 1979
Regulation promulgated under FIFRA; February 9, 1978
Regulation promulgated under RCRA; May 19, 1980
Technical assistance data; completed December 1979
Technical assistance data; completed June 1975
Summary review; completed March 1978
CHEMTRAX
ITC Master File
ITC Phase I Score File
ITC Phase II Score File
ITC Phase III Score File
- Chemical Hazard Information Profile (CHIP)
- Water Program's 65 Chemicals
Static Acute Toxicity Testing
Air Pollutants - Clean Air Act
Clean Water Act section 311 Chemicals
OSHA TLV
- FIFRA chemicals
- IARC Monographs
Assessment Division Pre-CHIP Screenings
Water Pollution Control Federation
Active Ingredients in Registered Pesticides
Fishbein List
NTP Testing Chemicals
Preliminary List Chemicals
59
-------
• Trioctylaluminum (1070-00-4)
EPACASR
Section 8 (a) regulation; proposed February 29,, 1980
CHEMTRAX
, - TSCA section 8(a) actions
V
• Trihexylaluminum (1116-73-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8 (a) actions
• Tridodecylaluminum (1529-59-5)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Tris(decyl)aluminum (1726-66-5)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• 2,5,8,ll,14-pentaoxahexadecan-16-ol (23778-52-1)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
60
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• Dichloroacetaldehyde (79-02-7)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
/ - TSCA section 8 (a) actions
V
• 2-hydroxy-4-(methylthio)-butanoic acid (583-91-5)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• 2,3,5,6-tetrachloro-l,4-benzenedicarbonyl dichloride (719-32-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8 (a) actions
• Tritetradecylaluminum (1529-58-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Trihexadecylaluminum (1726-65-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Trioctadecylaluminum (3041-23-4)
EPACASR
Section 8(a) regulation? proposed February 29, 1980
- 61
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CHEMTRAX
TSCA section 8(a) actions
• Butoxymethanol (3085-35-6)
EPACASR
, - Section 8(a) regulation; proposed February 29, 1980
*»'
CHEMTRAX
TSCA section 8(a) actions
• 1-octadecanol, sodium salt (3985-81-7)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• 2-methylpentanedinitrile (4553-62-2)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Propanoic acid, 2-methyl-, 2,2-dimethyl-l-(1-methylethyl)-1,3-
propanediyl ester (6846-50-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
• Thiosulfuric acid, monoammonium salt (10103-43-2)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
62
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1-octanol, aluminum salt (14624-13-6)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
1-dodecanol,aluminum salt (14624-15-8)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
2-hydroxy-4-(methylthio)-butanenitrile (17773-41-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
1-hexadecanol, aluminum salt (19141-82-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
1-hexanol, aluminum salt (23275-26-5)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section' 8(a) actions
1-decanol, aluminum salt (26303-54-8)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
63
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CHEMTRAX
TSCA section 8(a) actions
9-octadecenoic acid(Z)-, isooctyl ester (26761-50-2)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Cyclododecatriene (27070-59-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
ITC Phase III Score File
TSCA section 8 (a) actions
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REGION VII
The nine chemical substances exclusively manufactured in Region VII between
10-50 million Ibs/yr were not under consideration for any regulatory action as
reported for the FRSS between January 1, 1978, and October 8, 1980, when the
search was completed. No substances were exclusively produced in quantities
above the 10-50 million Ib/yr range.
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REGION VII
Perchloric acid, ammonium salt (7790-98-9)
EPACASR
Technical assistance data; completed December 1977
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Sepiolite (61180-58-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
67
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REGION VIII
Two chemicals exclusively manufactured in Region VIII at or above 10-50 million
Ibs/yr are subject to the following notice and proposed rule. Note that some
of the chemicals are listed for more than one action. Chemicals for each
action are listed below by their CAS number and CAS preferred names as they
appeared in the Federal Register.
Federal Register Notices
A. 45FR66506, October 7, 1980
Notice; Environmental Protection Agency, Office of Pesticides and Toxic
Substances, Toxic Substances Control Act
Interagency Testing Committee, chemicals for review for possible testing
recommendation under section 4 of TSCA. Comment period closed January 5,
1981.
CAS # CAS preferred Name
12200-88-3 Vanadic acid, hexasodium salt
B. 45FR13657, February 29, 1980
Proposed rule; Revision of 40CFR712, Environmental Protection Agency,
Office of Pesticides and Toxic Substances, Toxic Substances Control
Act 69
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Section 8(a) - proposed recordkeeping and reporting requirements.
CAS # CAS Preferred Name
12200-88-3 Vanadic acid, hexasodium salt
V
12161-82-9 Bertrandite
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REGION VIII
Bertrandite (12161-82-9)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Vanadic acid, hexasodium salt (12200-88-3)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
71
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REGION IX
Five chemicals exclusively manufactured in Region IX at or above 10-50 million
Ibs/yr are subject to the proposed TSCA section 8(a) rule. Chemicals for
V
each action are listed below by their CAS number and CAS preferred names as
they appeared in the Federal Register.
Federal Register Notice
A. 45FR13657, February 29, 1980
Proposed rule; Revision of 40CFR712 Environmental Protection Agency,
Office of Pesticides and Toxic Substances, Toxic Substances Control
Act
Section 8(a) - proposed recordkeeping and reporting requirements.
CAS #
CAS Preferred Name
69011-11-6 Sodium carbonate sulfate
1330-43-4 Boric acid, disodium salt
16349-83-0 Sulfuric acid, potassium sodium salt
7790-98-9 Perchloric acid, ammonium salt
61180-58-3 Sep'iolite
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REGION IX
Sodium carbonate sulfate (69011-11-6)
EPACASR
Section 8 (a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Boric acid, disodium salt (1330-43-4)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
Sulfuric acid, potassium sodium salt (2:3:1) (16349-83-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
75
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REGION X
Two chemicals exclusively manufactured in Region X at or above 10-50 million
Ibs/yr are subject to the proposed TSCA section 8(a) rule. Chemicals for
each action are listed below by their CAS number and CAS preferred names
as they appeared in the Federal Register.
Federal Register Notice
A. 45FR13657, February 29, 1980
Proposed rule; Revison of 40CFR712 Environmental Protection Agency,
Office of Pesticides and Toxic Substances, Toxic Substances Control
Act
Section 8(a) - proposed recordkeeping and reporting requirements.
CAS # CAS Preferred Name
7782-77-6 Nitrous Acid
62010-10-0 Zirconium oxide sulfate
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REGION X
Nitrous acid (7782-77-6)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
V
TSCA section 8(a) actions
Assessment Division Pre-CHIP Screenings
Zirconium oxide sulfate (62010-10-0)
EPACASR
Section 8(a) regulation; proposed February 29, 1980
CHEMTRAX
TSCA section 8(a) actions
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APPENDIX A
DESCRIPTION OF CHEMTRAX FILES
*TSCA SEC. 8(a) ACTIONS—under section 8(a) EPA may require manufacturers,
processors, or distributors to maintain records and submit reports on
V
certain chemical substances, mixtures, and categories of substances.
The type of information required may include chemical identification
use, manufacturer and adverse reactions to health or the environment.
Section 8(a) is expected to be particularly useful in defining categories
and determining the relative importance of category members. CHEMTRAX
will also report the dates of rules promulgated with respect to the
reporting and retention of information under TSCA section 8(a) once the
proposed rule is finalized.
*ITC TESTING RECOMMENDATIONS—summarizes the recommendations in the ITC reports
to the EPA Administrator. It is updated every 6 months as mandated by TSCA
section 4(e)_. The recommendation reported in CHEMTRAX simply indicates the
type of test ITC has recommended. Further testing may be recommended for the
following: carcinogenicity, mutagenicity, teratogenicity, other chronic
effects, environmental effects, and epidemiology.
*TSCA SEC. 8(d)—under section 8(d), EPA may require persons who manufacture,
process, or distribute certain chemical substances and mixtures to submit
lists of health and safety studies. The types of studies submitted under 8(d)
include those conducted or initiated by the submitter, known to that person,
or reasonably ascertainable by the person. CHEMTRAX reports the dates of
rules promulgated with respect to the submission of lists of health and safety
studies and the types of studies submitted.
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*WATER SEC. 311 CHEMICALS—prohibits the discharge of chemicals into the
navigable and coastal-shore waters of the U.S. Two hundred ninety-nine chemicals
have been designated as hazardous to date. These chemicals are considered
hazardous based on their acute toxicity to aquatic animals, aquatic flora,
and/or mammals.
The original regulation, promulgated 3/13/78, designated the chemicals in Data
Source 23 as hazardous. This regulation was revoked on March 13, 1978.
Another regulation, as amended version of the first regulation, was proposed
on February 16, 1979 and promulgated on August 29, 1979. This regulation
became effective on September 28, 1979. Where a chemical has been proposed
for deletion from the list, this revocation date is given. In some cases, the
proposed hazardous reportable quantity differs from the effective amount.
Differences between the old and new regulation can be ascertained from the
Federal Registers published on the forementioned dates.
*NTP TESTING—The National Toxicology Program encompasses a wide range of
toxicological testing being conducted throughout the Fesderal Government.
Participant agencies include NIEHS, FDA, Center for Disease Control, NIOSH,
and many subgroups of the National Institutes of Health. CHEMTRAX lists the
testing schedule, the type of testing, and the agency conducting the test.
*These five files correspond to those files listed on Chart B (page 12). The
NTP Testing file described on this page includes the types of tests completed
or in progress and thus the three NTP files on Chart B are incorporated into
this one NTP Testing category. The remainder of the CHEMTRAX files in
Appendix A are listed alphabetically.
— 82
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Description of CHEMTRAX Files
ACTIVE INGREDIENTS IN REGISTERED PESTICIDES—lists chemical substances
V
registered with OPP/EPA as active ingredients in pesticides.
ACUTE TOXICITY TO AQUATIC ORGANISMS—historical list of chemical substances
for which there are LD50 data for fish and/or aquatic invertebrates.
AD PRE-CHIP SCREENING—the Assessment Division screens chemical information
from journal articles, current awareness activities, government reports, and
other sources. For each chemical, a decision is made to continue or to
discontinue assessment. Continuation of assessment can result in a number
of further activities, including preparation of a production/use profile
(PUP) or a CHIP, or toxicity verification. When assessment is discontinued,
the rationale is given; i.e., low toxicity, low exposure, or regulation by
another office or agency.
AIR POLLUTANTS—reports on substances regulated under the Clean Air Act
which requires safe levels set or emissions restricted for certain substances.
ASSESSMENT DIVISION—CHEMICAL HAZARD INFORMATION PROFILES (CHIP)—refers
to chemicals for which CHIP Reports or Preliminary Chemical Profiles have
been selected or completed. This assessment process begins with evaluation
of section 8(e) notices, professional and trade journals, EPA, NCI, NIOSH, and
other agency publications to identify chemicals of potential concern and
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applicability under TSCA. Profile reports, which inclxide chemical charac-
teristics, production and use data, and health and environmental effects data,
are prepared within the Assessment Division. Following a review seminar,
dispositions are assigned to these chemicals. Possible* Assessment Division
actions range from referral to other agencies (CPSC, OSHA) or EPA offices,.
to continuation of the Assessment process with the. preparation of a more
detailed Phase I report. These dispositions, as well as the status of profile
preparation, are reported in CHEMTRAX.
CAG CHEMICALS—represents those chemicals being reviewed by the Cancer
Assessment Group. There are presently six defined decisions which can be
listed. Both the dates of action/decision and the disposition are recorded.
FIFRA CHEMICALS—file is in the process of being deleted.
FISHBEIN LIST—lists organic compounds which are considered potential
industrial carcinogens or mutagens. They were selected on the basis of their
reported carcinogenicity and/or mutagenicity, their relationships to known
carcinogens and mutagens, their volume or use characteristics, and suggested
or estimated potential populations at risk.
The purpose of the FISHBEIN study was to focus on the possible correlative
features, primarily structural, of a number of significant industrial chemicals
that have been reported in the literature to be carcinogenic and/or mutagenic.
This structural correlation could facilitate the prediction of potential
chemical hazards in the future, and the prioritization of existing potential
chemical carcinogens and mutagens for investigation in long-term animal studies.
84
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The information in the data source includes a number representing an assigned
class for each chemical. This is followed by a series of numbers, either
0, 1, 2, or 3 corresponding to the reported reaction of the chemical in
several areas of mutagenic or carcinogenic testing. (0) indicates that no
information was found on the chemical by the literature search in that area?
/ .
V
(1) indicates the chemical has been reported positively in that area;
(2) indicates the chemical was shown negatively in that area; and (3) indicates
that information was found to support both positive and negative results in
that area.
FOR YOUR INFORMATION—OTS frequently receives new information (or results of
studies) on chemical substances from private industry. Most of this infor-
mation comes in under TSCA section 8(e); however, occasionally it is submitted
on an informal "for your information" basis. The Assessment Division evaluates
these submissions in a status report, refers information to potentially
interested EPA offices or government agencies, and prepares a followup letter
that is sent to the submitter. CHEMTRAX lists relevant dates and study
information.
HAZARDOUS WASTE SITE CHEMICALS—this is a pointer data source listing chemicals
that have been identified at hazardous waste sites (taken from tables in
the EPA report Damage and Threats Caused by Hazardous Materials Sites, published
in 5/80 by the Oil and Special Materials Control Division (EPA/430/9-9-/004)).
Although it is only a partial compilation of damages and threats (from data
available during February and March 1980) it includes damages caused by
hazardous material migration covered in more than 350 site descriptions
including water contamination, drinking water well closures, fish kills,
85
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property damage from fires and explosions, kidney disorders, cancer, and
death. CHEMTRAX lists the names of the hazardous waste materials discussed
in this report.
IARC MONOGRAPH REVIEW—the International Agency for Research on Cancer (IARC)
has developed a program to evaluate the carcinogenicity risk of chemicals
to humans. In doing this, all relevant experimental and epidemiological
data about groups of chemicals for which there is known or possible human
exposure are collected and evaluated in terms of human risk. International
working groups of experts in chemical carcinogenesis and related fields
conduct these* evaluations and the conclusions of these working groups are
published as a series of monographs. The CHEMTRAX data source lists lARC's
conclusions, the volume number of the monograph, the production level for
each chemical reviewed, and results of tests (such as HP-human positive and
AS-animal suspected.)
IRLG REGULATORY DEVELOPMENT CHEMICALS—the Regulatory Workgroup of the IRLG
has taken on the responsibility for monitoring and reporting the development
of regulations on 20 selected chemicals at EPA, FDA, CPSC, and OSHA to foster
interagency coordination and awareness.
ITC MASTER LIST—contains all those chemicals perceived as potentially toxic
by the ITC and for which sufficient preliminary data were likely to be avail-
able for further selection and review of priority chemicals. Originally
constructed by intersecting 19 existing lists of "significant chemicals," the
committee's Initial Listing of 3,649 chemical substances constitutes the
ITC MASTER LIST in CHEMTRAX. The original source(s) naming each chemical is
(are) also referenced.
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The Initial Listing was reduced by eliminating substances which had only
pesticide, food additive, or drug uses, and which were therefore subject to
regulation by Federal statutes other than TSCA. In addition, chemicals which
were not commercially produced were dropped from further consideration and
scoring by ITC. Of the chemicals not deleted on the preceding process, 770
were assigned scores on a number of factors relating to exposure and environ-
mental release.
ITC PHASE I SCORE FILE—this scoring was done in June 1977 and represents
specific baseline data for chemicals from which the ITC made the initial
determination that further detailed study and reviews were required. The
relevant factors investigated in this phase, and which are also the data
variables from this source are:
Number Exposed
Exposure Frequency
Exposure Intensity
Penetrability
Quantity Released
Persistence
Production Volume
Occupational Exposure
Generally, the higher the score, the more pronounced the effect. For an
explanation of scoring methodology and interpretation of results, see the
ITC's Initial Report to the Administrator (October 1977).
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Based on the Phase I scores, chemicals were either deleted from consideration
or designated to the Preliminary List. The Phase I Deletion and Deletion
Dispositions reflect decisions made in constructing the Preliminary List.
ITC PHASE II SCORE FILE—this scoring represents the second level of ITC's •
initial evaluation process whereby additional data was gathered about a chemical
substance. The relevant biological scores gathered in this stage (Fall 1977),
which are also the data variables from this source are:
Carcinogenicity
Mutagenicity
Teratogenicity
Acute Toxicity
Other Toxic Effects
Ecological Effects
Bioaccumulation
Sum Numbered Scores (positive)
Sum Lettered Scores (negative)
Contaminants
Human Exposure Index
Environmental Exposure Index
Generally, scores ranging from 0.1 to 3.0 denote weak to strong evidence of
the effect. A zero score means that negative results were found when tested.
Scores ranging from -0.1 to -3.0 denote weak to strong suspicion of the effect
(based on structure/activity, etc.). For an explanation of scoring methodology
and interpretation of results, see the ITC's Initial Report to the Administrator
(October 1977).
_ 88
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The Biological activity scores were used to establish the hazardous potential
of each chemical, and were considered together with the exposure indexes in
designating certain chemicals for more detailed review. Following evaluation
of the Phase II scores, a Preliminary List classification (Code Table 28) was
assigned.
ITC PHASE III SCORE FILE—the third round of scoring done by the ITC (Fall 1978)
was based on the same methodology used in Phase I. The factors scored were
the same as in earlier scoring (see data source 2). CHEMTRAX variables are
summary scores for this round of exposure scoring:
Equal weight - the average of the number exposed, frequency, intensity,
penetrability, quantity released, and persistence
Human effects - the sum of the first four factors
Environmental effects - the sum of the last four factors
Production effects
Occupational exposure
Generally, the higher the score, the more pronounced the effect.
ITC PHASE IV SCORES—the Phase IV scores contain the results of biological
scoring done for the ITC in February of 1979. The scoring methodology was
essentially the same as for the Phase II scores.
NCI BIOASSAY CHEMICALS—consists of a list of chemicals that have been approved
for testing by NCI since July 1, 1977. Actual selection for testing is based
on physical chemical properties, level of priority assigned, availability
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and/or cost of the chemical, previous or concurrent testing elsewhere, etc.
The criteria for prioritization are the level of widespread exposure, relation
to known carcinogens, and results of previous tests or studies. The information
available in CHEMTRAX on chemicals selected for testing includes status of the
f
study, route of administration, species, and results.
j ,
NIOSH CRITERIA DOCUMENT—NIOSH publishes Criteria Documents on specific chemical
substances. These are comprehensive reports which are issued irregularly and
are intended to serve as the initial justification for regulatory action.
CHEMTRAX reports the stage of Criteria Document development as well as the
date they are transmitted to OSHA.
NIOSH CURRENT INTELLIGENCE BULLETINS—this system was (developed by NIOSH to
report new information on potential occupational hazards. In addition to
reporting epidemiological and laboratory animal studies, standards for industrial
hygiene and exposure levels may be recommended. The bulletins are usually
limited to a few pages in length and provide g^iick ove:rviews rather than in-depth
analyses. The CHEMTRAX data source notes the Bulletin number and date of
any chemicals in the NIOSH system.
OSHA CARCINOGENS—this data source is a list of substances that have been
categorized in conjunction with the Occupational Safety and Health Adminis-
tration's proposed Generic Carcinogen policy for the identification, classi-
fication, and regulation of toxic substances posing a potential occupational
carcinogenic risk.
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In putting together the list, three sources were used as the basis for an
elimination process. This list represents those substances considered to be
carcinogens that are found in the American working place. The chemicals listed
are limited to those that appeared on the NIOSH "Suspect Carcinogen" list,
and either the EPA TSCA Candidate List or the U.S. International Trade
j
Commission's 1976 data base (USITC). The EPA list and USITC list were used
as they are fairly accurate sources of chemicals found in the American work-
place. The chemicals are divided into category 1, 2, or 3. These are defined
below.
Category 1: chemicals whose carcinogenic!ty, as defined, has been determined
in humans, in two or more mammalian species of test animals, or
in one species if the results were replicated.
Category 2: chemicals whose carcinogenicity has been reported but the
evidence is for some reason only suggestive, as defined, or
positive in one species but not yet replicated.
Category 3:
those chemicals for which the evidence is inadequate to raise
any concern regarding carcinogenicity, or where the evidence
consists of animal data in a single species that is less than
suggestive.
PHASE I CHEMICALS—refers to chemicals for which "Phase I" reports have been
prepared with the Assessment Division subsequent to the reorganization and
formalization of its chemical assessment process in early 1978. These reports
are more detailed than the CHIP reports and are usually accompanied by
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contractor literature searches. Preparation of an outline, drafts, and the
final Phase I report are handled by the Assessment Division, with review of the
draft report by the various officers of OTS. The completed version of the
final report, which includes a discussion of the sources of exposure, is the
/
decision document. It is circulated to the Toxic Substances Priority Committee
members, who review it with their staffs. The TSPC then determines a course
of action for the chemical. The range of disposition options includes, among
others documented in the CHEMTRAX data files, "proceed to Phase II Report."
PHASE II CHEMICALS—refers to chemicals which are undergoing a more detailed
review (at the "Phase II" level). Both a detailed analysis of effects and a
paper discussing both TSCA control options and nonregulatory control options
are prepared. Based on the hazards, problems, and options presented, a
Phase II investigation may lead to regulatory action by OTS.
PRELIMINARY LIST CHEMICAL—list of chemicals to be used by OPTS when identifying
substances for potential regulation.
RESOURCE CONSERVATION AND RECOVERY ACT (1976): 3001 Hazardous Waste—RCRA
provides "for the development of management plans and facilities for the
recovery of energy and other resources from discarded materials and for the
safe disposal of discarded materials and for the regulation of management of
hazardous waste." Section 3001 of the act directs EPA to list hazardous solid
wastes which are subject to regulation. Variables listed in the file are
Regulatory Determination (ex: hazardous waste, discarded commercial chemical
product) and maximum concentration level.
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SAFE DRINKING WATER ACT—this data source is a list of substances contained in
the National Primary and Secondary Drinking Water Regulations, promulgated in
accordance with the Safe Drinking Water Act (SDWA). These regulations cite
maximum contaminant levels for community water systems, monitoring and analytical
retirements to ensure compliance, and notification, and record-keeping of-
analytic and compliance data.
The data source contains a list of the substances regulated, the proposal,
promulgation and effective dates of regulation, and a description of the
regulation. Two general types of regulations are described.
Primary regulations are devoted to constituents and properties directly affecting
the health of the consumer. These take the form of either maximum contaminant
levels or monitoring guidelines for water treatment that list indicators of
industrial contaminants. In a few cases, one chemical has been regulated with
both a maximum contaminant level and a contaminant indicator.
Secondary regulations deal with the aesthetic qualities of drinking water,
applying to contaminants that are not a health threat, but affect the taste,
odor or appearance of public drinking water. These maximum contaminant levels
are not federally enforceable; the implementation of secondary drinking water
regulations is under the authority of the states.
The codes used in the data source to describe SDWA regulations are as follows:
(1) Secondary Regulations: Maximum Contaminant Level
(2) Primary Regulations: Maximum Contaminant Level - Trihalomethanes
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(3) Primary Regulations: Contaminant Indicators - Synthetic Organic Chemicals
(4) Primary Regulations: Maximum Contaminant Levels - Inorganic Chemicals
(5) Primary Regulations: Maximum Contaminant Levels - Organic Chemicals
(6) Primary Regulations: Maximum Contaminant Level - Organic (also Contaminant
/
Indicators - Synthetic Organic Chemicals)
SPECIAL PESTICIDES REVIEW DIVISION—EPA has developed a registration review
process in which the human and environmental risks posed by a pesticide are
weighed against the benefits of the pesticide to users and consumers. The
process is called Rebuttable Presumption Against Registration (RPAR) and is
carried out in the Office of Special Pesticide Reviews (SPRD) of OPP.
In the first phase of the RPAR process ("pre-RPAR review") all significant
scientific information on potential hazards associated with the pesticide is
gathered, reviewed and summarized in a position document (PD 1) which is pub-
lished in the Federal Register and mailed to registrants and other interested
parties. An RPAR is issued if the information indicates: that the pesticide
poses any of the following hazards: 1) acute toxicity to humans and domestic
animals or fish and wildlife after low exposure; 2) chronic toxicity, including
oncogenicity, mutagenicity, teratogenicity, fetotoxicity and other chronic or
delayed effects, and reduction in populations of nontarg-et or endangered
species; or 3) lack of emergency treatment. Registered products containing
the pesticide may continue to be used after the RPAR is issued unless it is
canceled or suspended..
If the scientific information does not indicate that these hazards exist, the
pesticide is returned to the registration process. If an RPAR is issued, the
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Agency moves to the second phase, the rebuttal period. The rebuttal period
("comment period") extends for 45 (or in some cases, to 105) days during which
registrants, user groups, environmental groups, and any other persons may send
the Agency data which either supports or refutes presumption of risk. During
this rebuttal period, the agency also begins to look for information on the
benefits of the pesticide. After an analysis of all comments, if the rebuttal
is judged to be successful, the pesticide is returned to the registration
process.
If the rebuttal is not successful, the Agency initiates a more detailed risk/
benefit assessment. The benefits associated with each use and regulatory option
are then compared with corresponding risks. If the risks appear to outweigh
the benefits, the Administrator may either propose to impose certain restrictions
on its use or to cancel a particular use of the pesticide. If the Administrator
finds the benefits to outweigh the risks, he may propose to reregister the
pesticide. On the date of the Administrator's final decision, these Notices
of Intent to Cancel (or to Register) appear in the Federal Register.
The OPSR also evaluates pesticides for which some or all uses have been
voluntarily canceled by the producer (via a notice in the Federal Register.
Often, however., RPAR or pre-RPAR review continues when only uses are dis-
continued .
CHEMTRAX indicates the current disposition of the pesticide within or following
the review process. The dates of the first and final Federal Register notices
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are given, as well as the closing date for rebuttal comments, and dates of
any voluntary cancellations of chemicals outside the RFAR process. Until the
RPAR and risk analysis phases are complete, the CHEMTRAX "Date of PD 1" and
"Date of Final Decision of Administrator" entries represent approximate goals
set by OSPR.
STATIC ACUTE TOXICITY TESTING—this data source lists chemicals for which
static acute toxicity tests have been run. ^CCQI are referenced for several
species of aquatic organisms (fresh water algae, water flea, bluegills, salt
water algae, mysid shrimp, and sheepshead minnow). CHEMTRAX lists only the
chemicals tested.
TSCA SEC. 8(c) ACTIONS—reports the dates of rules promulgated with respect to
the reporting and retention of information on adverse reactions to health or the
environment.
TSCA SEC. 8(e)—under Section 8(e), any person having information which reasonabl
supports the conclusion that a substance presents a substantial risk to health
or to the environment must immediately inform the EPA Administrator to that
effect. Notices of Substantial Risk are directed to the Assessment Division
which coordinates review and action. A status report on each 8(e) submission
is prepared indicating the nature of the submission and any follow-up actions
which are taken. The data available in CHEMTRAX are: type of study; dispo-
sitions; chemical company; date of notice received; date of OTS action; sub-
mission number; date"of status report, and information on follow-up actions.
WATER POLLUTION CONTROL FEDERATION—the WPCF review is a summary of acute and
chronic toxicity of inorganic and organic pollutants to freshwater fish.
96
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WATER PROGRAM (65 chemicals)—under the Clean Water Act, (Section 304) EPA
is required to publish and periodically update water quality criteria. In
compliance with this, EPA must publish criteria for 65 specified toxic
pollutants which state the maximum recommended concentrations consistent •
with the protection of aquatic life and human health. If a chemical
searched in CHEMTRAX is part of this group it will be noted. The number
of chemicals listed in CHEMTRAX is greater than 65 because some of the
pollutants are groups, and in CHEMTRAX the group numbers are listed.
97
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JEPORT DOCUMENTATION IMPORT HO. 2.
PAGE EPA 560/TIIS-81-005
.. Trtte and Subtitle
TSCA Chemicals in Commerce Inventory: Regional and Status
Perspectives
. Author**)
)aryl L. Kaufman, Bob Janney, Donn Viviani
, Performing Organization Nam* and Address
J.S. EPA
)ffice,of Toxics Integration (TS-777)
.01 "M" Street, SW
7ashington, B.C. 20460
. Sponsoring Organization Nam* and Address
ame as 9 above.
S. Recipient' • Accession No.
5. Raport Oat*
August 1981
6.
8. Performing Organization R*pt. No.
10. Project/Task/Work Untt No.
It. Contract(C) or Grant(G) No.
(O
(G)
13. Type of Raport & Period Covered
TIIS October 1980
14.
. Supplementary Notes
Abstract (Limit: 200 words)
sing the CICIS Inventory it was possible to determine which chemical substances
ere produced exclusively in each of the 10 EPA regions. Slightly less than 50%
f the inventory is region-specific. Confidential Inventory runs do not affect
lis finding. A regulatory status of the top 440 high production volume
lemicals (a production volume range of 10-50 million Ibs/yr was selected as a
it-off point) was completed and it appeared that only 95 specific chemical
ubstances were undergoing any sort of assessment, regulation development,
: were already regulated. Document will provide the regions guidance
i their priority setting.
Document Analysis a. Descriptors
b. Identifiers/Open-Ended Term*
Region-specific chemicals
CICIA Inventory
c. COSATl Field/Group
Availability Statement
». Security Class (This Report)
20. Security Class (This Page)
21. No. of Pages
22. Price
ANSUZ39.lt)
See Instruction* on Reverse
OPTIONAL n>RM 272 (4-77)
(Formerly NTIS-3S)
Department of Commerce
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