vvEPA
United States
Environmental Protection
Agency
Solid Waste and
Emergency Response
EPA-540-R-97 036
PB97-921199
July 1997
Superfund
Health Effects Assessment
Summary Tables
FY 1997 Update
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9200.6-303(97-1)
EPA 540/R-97-036
PB97-921199
July 1997
HEALTH EFFECTS ASSESSMENT
SUMMARY TABLES
FY-1997 Update
Office of Research and Development
Office of Emergency and Remedial Response
U.S. Environmental Protection Agency
Washington, DC 20460
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HEALTH EFFECTS ASSESSMENT SUMMARY TABLES
FY-1997 UPDATE
Prepared by:
International Consultants Inc.
Dayton, OH
Contract No. 68-C6-0082
Prepared for:
National Center for Environmental Assessment
U.S. Environmental Protection Agency
26 West Martin Luther King Drive
Cincinnati, OH 45268
Adib "Ed" Tabri, Technical Project Monitor
Patricia A. Daunt, Alternate Project Officer
Bette Zwayer, Project Officer
July 31, 1997
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DISCLAIMER
This report has been prepared by the U.S. Environmental Protection Agency. The
information contained herein has been taken from final documents prepared by the National
Center for Environmental Assessment for the Office of Solid Waste and Emergency Response
and the Office of Water, Washington, DC and the Office of Air Quality Planning and Standards,
Research Triangle Park, NC. These documents were reviewed in accordance with Agency
policy and approved for publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
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TABLE OF CONTENTS
Page
INTRODUCTION 1
WHAT'S NEW IN THE FY97 HEAST UPDATE 10
USER'S GUIDE: CHEMICAL TOXICITY 14
USER'S GUIDE: RADIONUCLIDE CARCINOGENICITY 27
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) 1-1
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY) R1-1
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) 2-1
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -
SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) R2-1
HEAST TABLE 3: CARCINOGENICITY 3-1
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY R3-1
HEAST TABLE 4: RADIONUCLIDE CARCINOGENICITY - SLOPE
FACTORS (IN UNITS OF PICOCURIES) 4-1
APPENDIX A: TECHNICAL INFORMATION A-1
Hi
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INTRODUCTION
This document is an FY97 Update of the Health Effects Assessment Summary Tables
(HEAST) prepared by EPA's National Center for Environmental Assessment, Cincinnati, OH
(NCEA-CIN) for use at both Superfund and RCRA sites. It is intended to replace former
editions and supplements of the HEAST. The HEAST will be updated annually if sufficient new
data exist.
The HEAST is a comprehensive listing consisting almost entirely of PROVISIONAL
RISK ASSESSMENT INFORMATION relative to oral and inhalation routes for chemicals of
interest to Superfund, the Resource Conservation and Recovery Act (RCRA), and the EPA in
general. Although these entries in the HEAST have undergone review and have the
concurrence of individual Agency Program Offices, and each is supported by an Agency
reference, they have not had enough review to be recognized as high quality, Agency-wide
consensus information.
The Integrated Risk Information System (IRIS) is the Agency's official repository of
Agency-wide consensus chronic human health risk information. Until recently, IRIS evaluations
were conducted by the Agency's Work Group Review process. To improve IRIS and to make it
more useful, EPA requested and received public comment. As a consequence the Agency has
initiated an IRIS Pilot program to replace the Reference Dose/Reference Concentration
(RfD/RfC) and the Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Groups.
The Pilot will produce new or updated toxicological reviews and IRIS entries containing
Agency consensus scientific positions on potential adverse human health effects that may
result from chronic exposure to environmental contaminants.
The Pilot process consists of (1) a call for public involvement for interested parties to
have some level of input into IRIS technical information, (2) a search of the relevant literature,
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(3) development of toxicological reviews and draft IRIS summaries, (4) internal peer review
within EPA, (5) external peer review by experts selected for each substance outside EPA,
(6) consensus review and management approval within EPA, (7) preparation of final IRIS
summaries and supporting documents, and (8) entry of summaries into the IRIS database.
Currently, the Pilot process, which has been underway since early FY 1996, is being
applied to a select group of chemical substances chosen on the basis of the Agency's need for
new or updated hazard or dose-response information. These assessments will be included in
IRIS, and do not appear in the HEAST.
There are two exceptions to the above discussion. The HEAST also contains
information on chemicals included under the National Ambient Air Quality Standards (NAAQS)
and the Drinking Water Criteria Document (DWCD) series. In each of these cases, the
chemicals are subject to extensive scientific peer review for quality assurance.
CHEMICAL STATUS DEFINITIONS
Chemicals previously reviewed by the Agency for consensus are classified according to
their status as either "verified," "not verifiable," or "under review." The toxicity values (other
than NAAQS or DWCD values) listed on the HEAST are considered to be "provisional." The
Agency has no official definitions for these terms, but the HEAST user may interpret them as
follows:
Provisional: A toxicity value or a cancer value is "provisional" if the value has
had some form of Agency review, but it does not appear on the IRIS system.
These values are generated in several ways. Often they are determined in the
course of developing an Agency document on a chemical or on a class of
chemicals. Some have been generated through the earlier Work Group process,
but have not yet been input to the IRIS system. At the time each value was
derived, all available information on the chemical was evaluated, the value was
calculated using the most current methodology, and a consensus was reached
on the value by Agency scientists.
Brackets are placed around the names of toxicity and carcinogenicity values on
the HEAST to distinguish these "provisional" values from information on IRIS.
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The following names are affected: RfD to [RfD], RfC to [RfC], slope factor to
[slope factor], EPA group to [EPA Group] and unit risk to [unit risk].
These "provisional" values are found on the HEAST. They do not appear
on IRIS.
Verified: A toxicity value or a cancer value receives Agency consensus as
"verified" after all available information has been reviewed and a value has been
calculated using current methodology. Verified values are entered on IRIS.
Some numbers that have achieved unanimous consensus by the previous
Agency Work Groups may appear on the HEAST as "provisional" values.
These "verified" numbers only appear on IRIS. They do not appear on the
HEAST.
Not verifiable: A toxicity value is "not verifiable" if all available data on a
chemical was determined by the Agency to be inadequate to generate a value
that would be suitable for inclusion on IRIS. No toxicity value is calculated; no
toxicity value is available for IRIS or the HEAST.
This "not verifiable" status is noted on IRIS, and is sometimes found on
the HEAST, with a pointer to the IRIS system.
Under Review: A toxicity value is "under review" if it is undergoing the Pilot
process of considering all available data. All Pilot chemicals will have this status
until the toxicity value is placed on IRIS.
This "under review" status may be indicated on IRIS or on the HEAST.
During this time, "provisional" toxicity values may appear on the HEAST.
Note: In all cases, the status of a chemical may change as new data become available,
and the assessment is revisited, reviewed and verified through the Pilot Proces
previously described.
CAUTION
It is imperative for each user of the HEAST to recognize that the values listed in the
toxicity tables and the cancer table are generally considered to be PROVISIONAL RISK
ASSESSMENT INFORMATION. The user is referred to IRIS for earlier "Work Group Verified"
values. It is also important to remember that the numbers in these tables alone tell very little
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about the adverse effects of a chemical or the quality of evidence on which risk assessment
information is based. Original assessment documents must be consulted by users of the
HEAST in order to fully appreciate the strengths and limitations of a specific data base. Original
source documents will allow for the most complete characterization of potential toxicity
associated with the range of exposure pathways generally evaluated at Superfund and RCRA
sites. The Reference Tables point the user to these sources.
CONTRIBUTORS
Chemicals commonly found at RCRA sites as identified by the Office of Solid Waste's
(OSW) Technical Assessment Branch are included in the HEAST. The Office of Radiation
Programs has provided data on radionuclide carcinogenicity for Table 4. Finally, the Office of
Air Quality Planning and Standards (OAQPS) has provided information on chemicals for which
Air Quality Criteria Documents and National Ambient Air Quality Standards have been
developed.
CHEMICALS LISTED
Most of the chemicals included on the toxicity tables and carcinogenicity table are those
for which at least one of the following EPA documents has been written: Health Effects Assess-
ment Document (HEA), Health and Environmental Effects Profile (HEEP), Health and
Environmental Effects Document (HEED), Health Assessment Document (HAD), Air Quality
Criteria Document (AQCD), Drinking Water Criteria Document (DWCD). A description of each
is provided in Appendix A, Section I. In a few cases, the values are supported by other written
material, such as Work Group meeting notes or Carcinogen Assessment Group (CAG) Profiles.
Radionuclide slope factor values are calculated by the EPA's Office of Radiation Programs.
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The names of criteria pollutants that are regulated as National Ambient Air Quality
Standards (NAAQS) under the Clean Air Act are listed in the main body of the HEAST, but the
actual criteria are included as Section V of Appendix A. The NAAQS were not included in the
tables in order to distinguish them from the reference concentration ([RfC]) values. The
NAAQS and [RfCJs represent different levels of review and different methods of calculation and
thus, must be interpreted and used differently.
HIERARCHY OF SOURCES
It is recognized that at any point in time there may be multiple old and new Agency
documents or data bases that present different values on a specific chemical. For chemicals
other than those represented by the NAAQS or DWCDs, the following hierarchy of sources is
recommended in evaluating chemical toxicity for Superfund sites:
1. The Agency's Integrated Risk Information System (IRIS) and cited
references. Changes are made in this data base on a monthly basis, but
there may be data gaps. Call the RISK INFORMATION HOTLINE at
(513)569-7254 for further information.
2. The Health Effects Assessment Summary Tables (HEAST) and cited
references.
3. Consultation with the Superfund Health Risk Technical Support Center
(TSC) at (513)569-7300.
4. Do not consult either the toxicity tables (Appendix A) in the Superfund
Public Health Evaluation Manual (SPHEM, U.S. EPA, 1986) or the
September 1988 Public Health Risk Evaluation Data Base (PHRED) as
these sources are likely to contain numerous values that have since
become out-of-date.
QUESTIONS
Chemical Toxicity and Carcinogenicity
Questions regarding the contents of the chemical toxicity and carcinogenicity tables on
the HEAST (e.g., chemicals not covered, chemicals with pending [RfD]s) may be directed to
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EPA's Superfund Health Risk Technical Support Center (TSC) in Cincinnati, OH at
(513)569-7300 [FAX#: (513)569-7159]. Requests should include the following information:
Superfund site name, site location and twelve-digit site number;
Name and phone number of the site Remedial Project Manager (RPM) or
Regional Risk Assessor/Toxicologist;
Detailed description of the risk assessment related question.
Written requests should be mailed to:
Superfund Health Risk Technical Support Center
US EPA
26 W. Martin Luther King Dr.
National Center for Environmental Assessment
MS - G44
Cincinnati, OH 45268
Radionuclide Carcinogenicity
Questions concerning radionuclide carcinogenicity should first be addressed by
contacting the appropriate Regional Radiation Program Manager. A revised listing of these
managers and several contacts in the Office of Radiation Programs can be found in Exhibit 2 of
the User's Guide - Radionuclide Carcinogenicity.
REFERENCES
Most cited Agency references (e.g., HEAs, HEEPs, HEEDs), are available through the
National Technical Information Service (NTIS), 5285 Port Royal Road, Springfield, VA 22161
[(703)487-4650]. Carcinogen Assessment Group (CAG) Profiles cited in Table 3 are available
through the RCRA docket (703)603-9230.
Drinking water documents are available by calling the Water Resource Center at
(202)260-7786.
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ORDERING INFORMATION
Limited copies of the HEAST are available for EPA Superfund staff, State Superfund
programs and other Federal agencies working on Superfund sites, and EPA contractors
working for the EPA Superfund program. Users in these groups can call International
Consultants, Inc. (513)569-7300 to be put on the mailing list. Regional OSW staff are reminded
that copies are sent to all EPA Regional libraries.
Users of the HEAST in EPA's Office of Air and Radiation and State air programs should
call Roy Smith of EPA's Office of Air Quality Planning and Standards at (919)541-5632.
All other users must purchase the document from:
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
(703)487-4650
For ordering information, call the NTIS Subscriptions Department at (703)487-4630.
NTIS normally ships 4th class United States mail. When ordering the 1997 Health Effects
Assessment Summary Table annual update from NTIS refer to the following order number:
PB97-921199: FY97 Annual HEAST update
STRUCTURE OF THE HEAST
The HEAST Introduction contains explanatory material relative to the quality of
information on the HEAST, its sources, and its availability. This is followed by a listing of
changes since the last HEAST was published and then by User's Guides for both Chemical
Toxicity and Carcinogenicity, and Radionuclide Carcinogenicity. The values on the HEAST are
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presented in a series of five tables that contain toxicity information and three tables of
references. The information contained in each table and their designations are as follows:
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
Table 1 lists subchronic and chronic non-cancer toxicity values that were
calculated using the methodology practiced by the RfD/RfC Work Group.
HEAST TABLE 1 REFERENCES: SUBCHRONIC AND CHRONIC TOXICITY (OTHER
THAN CARCINOGENICITY)
The references for Table 1 are numerically coded to associate each toxicity
value clearly with its corresponding reference.
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY)
Table 2 lists subchronic and chronic non-cancer toxicity values that are found in
Agency documents, but were calculated by alternative methods that were not
practiced by the RfD/RfC Work Group. These values are considered to be
adequate provisional values for risk assessment purposes at Superfund and
RCRA sites, but are to be reviewed and revised when necessary to reflect
current information.
HEAST TABLE 2 REFERENCES: ALTERNATE METHODS - SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
The references for Table 2 are numerically coded to associate each toxicity
value clearly with its corresponding reference.
HEAST TABLE 3: CARCINOGENICITY
Table 3 lists carcinogenicity values that were calculated by the CRAVE Work
Group using Agency methodology.
HEAST TABLE 3 REFERENCES: CARCINOGENICITY
The references for Table 3 are numerically coded to associate each toxicity
value clearly with its corresponding reference.
HEAST TABLE 4: RADIONUCLIDE CARCINOGENICITY - SLOPE FACTORS
(In Units of Picocuries)
Table 4 lists ingestion, inhalation and external exposure carcinogenicity slope
factors for radionuclides in units of picocuries and a factor to convert into the
International System (SI) activity units of becquerels (Bq).
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Following the tables, a Technical Appendix (Appendix A) is available, containing the
following sections:
I. Data Sources and Selection Criteria Used in HEAST
II. Dose Conversions on HEAST
III. Chemical Name and Chemical Abstracts Service
Registry Number Cross Reference
IV. Effect Level Definitions
V. National Ambient Air Quality Standards (NAAQS)
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WHAT'S NEW IN THE FY97 ANNUAL HEAST
GENERAL CHANGES -- CHEMICAL TOXICITY AND CARCINOGENICITY
The changes in this version of the HEAST reflect changes in IRIS through July 1,
1997.
CHEMICAL-SPECIFIC CHANGES -- CHEMICAL TOXJCITY AND CARCINOGENICITY
A. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 1: SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Benzo[b]fluoranthene 000205-99-2
Removed from Table 1 due to incomplete subchronic [RfC] assessment.
Bis(2-chloroisopropynether 039638-32-9
Removed general comment from Table 1.
Chlorobenzene 000108-92-7
Removed from Table 1 the subchronic [RfD] comment due to incomplete assessment.
Dichloroethane. 1.2- 000107-06-2
Removed from Table 1 due to incomplete subchronic [RfC] and [RfD] assessments.
Manganese 007439-96-5
Removed the subchronic oral water [RfD] from Table 1 and citation 010850 from
References to Table 1.
Trichloroethane. 1.1.1- 000071-55-6
Removed subchronic [RfC] comment from Table 1 due to incomplete assessment.
Uranium. Soluble Salts No CAS #
Removed from Table 1 due to incomplete assessment.
B. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 2: ALTERNATE
METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
Dicvclopentadiene 000077-73-6
Changed target organ from liver to kidney.
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C. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3: CARCINOGENICITY
Allyl chloride 000107-05-1
The general comment, "contact the Health Assessment Section" is removed from
Table 3.
Arsenic, inorganic 007440-38-2
Removed inhalation [slope] factor value and comment from Table 3.
Benzo(b)fluoranthene 000205-99-2
Removed general comment.
Benzo(k)fluoranthene 000207-08-9
Removed the general comment, "contact the Health Assessment Section".
Chloromethvl methyl ether 000107-30-2
The general comment, "contact the Health Assessment Section" is removed.
Chrvsene 000218-01-9
The general comment, "contact the Health Assessment Section" is removed.
Dibenzo[a.h]anthracene 000053-70-3
The general comment, "contact the Health Assessment Section" is removed.
Dichloroethane. 1.2- 000107-06-2
The inhalation [slope] factor and comment are removed from Table 3.
Dimethylbenz[a]anthracene. 7,12- 000057-97-6
Removed from Table 3. The general comment, "contact the Health Assessment
Section" is removed from Table 3 References.
Methylcolanthracene. 3- 000056-49-5
Removed from Table 3 and from Table 3 References.
Nitroso-n-ethylurea. N- 000759-73-9
Removed the general comment, "contact the Health Assessment Section".
Polychlorinated biphenyls 001336-36-3
Added general comment: Carcinogenicity information was changed on IRIS.
D. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 4: RADIONUCLIDE
CARCINOGENICITY - SLOPE FACTORS
No changes made to Table 4.
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CHEMICAL SPECIFIC CHANGES MADE IN THE NOVEMBER 1995 SUPPLEMENT
TO THE MAY 1995 HEAST ANNUAL UPDATE
The following changes were made in the November 1995 supplemental edition of the
May 1995 HEAST Annual Update. Because some users may have been unaware of
the publication of the November 1995 supplement, the following information should be
noted.
A. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 1: SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Antimony trioxide 001309-64-4
An indicator was added to show that an inhalation RfC has been added to IRIS. The
chronic inhalation RfC was adopted as the subchronic inhalation [RfC].
Boron, elemental 007440-42-8
The subchronic oral [RfD] was removed because the chronic oral RfD on which it was
based is under review by the RfD/RfC Work Group.
Carbon disulfide 000075-15-0
An indicator was added to show that an inhalation RfC has been added to IRIS. The
chronic inhalation RfC was adopted as the subchronic inhalation [RfC].
Hydrogen sulfide 007783-06-4
After a revaluation of uncertainty factors by the RfD/RfC Work Group, the chronic
inhalation RfC was modified to estimate the subchronic inhalation [RfC].
Mercuric chloride 007487-94-7
After a reevaluation of uncertainty factors by the RfD/RfC Work Group, The chronic oral
RfD was modified to estimate the subchronic oral [RfD].
Phosphine 007803-51-2
An indicator was added to show that an inhalation RfC has been added to IRIS. The
chronic inhalation RfC was modified to estimate the subchronic inhalation [RfC].
B. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 2: ALTERNATE
METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
There were no changes to Table 2.
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C. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3: CARCINOGENICITY
Arsenic, inorganic 007440-38-2
Indicators were added to show that an oral slope factor and an oral unit risk have been
added to IRIS.
Bis(2-chloro-1 -methylethyl) ether 000108-60-1
A typographical error in the CAS Registry Number has been corrected. There were no
other changes to the record.
D. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 4: RADIONUCLIDE
CARCINOGENICITY - SLOPE FACTORS
For the November 1995 Supplement of the HEAST for radionuclides, EPA's Office
of Radiation and Indoor Air (ORIA) has:
/ corrected the factor in Table 4 for converting radionuclide slope factors from the
customary units of picocuries (Ci) to the International System (SI) units of
becquerels (Bq). (To convert radionuclides slope factors into the SI units of Bq,
users should multiply each value in Table 4 by 27.03, not by 3.70E-02, the
conversion factor provided in the May 1995 update.)
/ added ingestion, inhalation, and external exposure slope factors for californium
(Cf-252), iridium (lr-192), thallium (TI-207), and silver (Ag-110m+D).
/ removed the ingestion, inhalation, and external slope factors for Cm-243+D and
Pu-241+D. (EPA/ORIA re-evaluated the derivation and use of "+D" slope factors
for decay chains that include a parent radionuclide (e.g., Cm-243 or Pu-241) with a
radioactive half-life much shorter than the half-life of its immediate decay product
(e.g., Pu-239 in the case of Cm-243 and Am-241 in the case of Pu-241). ORIA
concluded that using "+D" slope factors for these types of radionuclides and decay
chains may significantly underestimate radiation exposure and risk at certain sites,
because such factors cannot be derived to cover all possible equilibrium conditions
in the environment. At sites contaminated with these types of radionuclides, ORIA
recommends that users (1) determine the radioactivity concentrations of the parent
and each decay product radionuclides separately, (2) apply the appropriate slope
factors in Table 4 for each radionuclide individually, and (3) add the individual risks
from each radionuclide to calculate the collective risk posed by the site.)
/ corrected the external slope factor values for Ac-227+D, Ce-144+D, Pu-244+D,
Th-228+D, Th-229+D, and U-238+D in Table 4.
/ corrected the branching factor for Ce-144 to Pr-144 from 9% to 98%, and
corrected the half-life for Ra-228 from 8 years to 6 years in Exhibit 1.
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USER'S GUIDE: CHEMICAL TOXICITY
The HEAST summarizes provisional toxicity and cancer values as well as values
developed for the NAAQS and DWCD chemicals. The provisional status of the toxicity
and cancer values is indicated by placing brackets around the title of the value. These
include provisional reference concentrations ([RfC]) and provisional reference doses
([RfD]) for toxicity from subchronic and chronic inhalation and oral exposure (Tables 1
and 2) and provisional slope factors ([slope factor]), provisional cancer classifications
([EPA Group]) and provisional unit risk values ([unit risk]) for carcinogenicity, based on
lifetime inhalation and oral exposure (Table 3). Brackets should be included with the
acronym whenever a user quotes the value in an assessment document, and the
provisional nature of the value should be noted. A more complete discussion of how
Superfund develops and considers the toxicity assessment in hazardous waste sites is
presented in Chapter 7 of Risk Assessment Guidance for Superfund Volume 1: Human
Health Evaluation Manual, Part A, EPA/540/1-89/002.
The references listed for each chemical in the Reference Tables for Tables 1, 2
and 3 represent the study or studies that are the basis for the [RfC], [RfD], [slope
factor], [EPA Group], or [unit risk], as well as the EPA reference that is the source of the
Agency analysis or risk assessment information. In some cases, additional EPA
documents are also listed as a source of information on the chemical. Verified values
found on IRIS are not found on the HEAST, but are indicated in the tables by the word
"IRIS" in place of the number.
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TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINO-
GENICITY)
The [RfC] or [RfD] is a provisional estimate (with uncertainty spanning perhaps
an order of magnitude) of the daily exposure to the human population (including
sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects
during a portion of the lifetime, in the case of a subchronic [RfC] or [RfD], or during a
lifetime, in the case of a chronic [RfC] or [RfD]. The [RfC] and [RfD] values are listed in
Tables 1 and 2 in columns with the headings "Subchronic" and "Chronic". The critical
dose or concentration level is usually a No-Observed-Adverse-Effect Level (NOAEL) or
a Lowest-Observed-Adverse-Effect Level (LOAEL) (See Appendix A, Section IV: Effect
Level Definitions, for more information). The [RfC] or [RfD] is derived by dividing the
NOAEL or LOAEL by an uncertainty factor (UF) times a modifying factor (MF):
[RfC] or
UF x MF
In Tables 1 and 2, the information listed is the following:
Chemical = Chemical Name/CASRN
Level = Effect Level
Dose = Administered Dose or Concentration
Route = Route of Administration
Species = Tested Species
Experiment Length = Length of Exposure
Target = Target Organ(s) Affected at Critical Level
Critical Effect = Effect(s) Observed at Critical Level
Subchronic [RfC] = Subchronic Inhalation [Reference Concentration]
UF = Uncertainty Factor for the Subchronic Inhalation
[Reference Concentration]
Subchronic [RfD] = Subchronic Oral [Reference Dose]
UF = Uncertainty Factor for the Subchronic Oral [Reference
Dose]
Chronic [RfC] = Chronic Inhalation [Reference Concentration]
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UF
Chronic [RfD]
UF
Reference
Uncertainty Factor for the Chronic Inhalation [Reference
Concentration]
Chronic Oral [Reference Dose]
Uncertainty Factor for the Chronic Oral [Reference
Dose]
Reference Identification Number for All Toxicity Values
on the Same Line.
An example of this information is shown in Figure 1, HEAST Table 1:
Chemical
Level
Dose
Route
Species
Experiment Length
Target
Critical Effect
Subchronic [RfC]
UF
Subchronic [RfD]
UF
Chronic [RfC]
UF
Chronic [RfD]
UF
Reference
GLYCIDALDEHYDE/000765-34-4
NOAEL
10 PPM
INHALATION: INTERMITTENT
RAT
12 WEEKS
WHOLE BODY, BLOOD, KIDNEY
DECREASED WEIGHT GAIN, HEMATOPOIETIC
EFFECTS
1E-2 mg/cu.m
300
4E-3 mg/kg/day
300
1E-3 mg/cu.m
3000
IRIS
IRIS
005968
Notice that a Chronic RfD for Glycidaldehyde is available on IRIS, so it is not listed
here. Also notice that there are footnotes for this chemical that indicate a route-to-route
extrapolation was performed and that there is information available on Table 3:
Carcinogenicity.
Also given in Figure 1 is an example of the References for Table 1 for the same
chemical. The reference is identified by the chemical name (Glycidaldehyde), the
CASRN (00765-34-4), and the reference number that links it with the toxicity values
(005968).
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CHEMICAL DOSE
LEVEL ROUTE
GLYCIDALDEHYDE
NOAEL 10 PPM
INHALATION
INTERMITTENT
FIGURE 1
Example Data and References for Chemical Toxicity
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SPECIES
EXPERIMENT LENGTH TARGET
000765-34-4
RAT
12 WEEKS WHOLE BODY
BLOOD
KIDNEY
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
Cmo/cu m) (mg/kq/dav) (mg/cu m) (mq/kq/dav)
UF UF UF UF
1E-2 4E-3 1E-3 IRIS
DECREASED WEIGHT GAIN 300 300 3000
HEMATOPOIETIC EFFECTS
EFFECTS
005968
SUBCHRONIC [RfD] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5
CHRONIC [RfD] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5
GENERAL COMMENT ALSO SEE TABLE 3 CARCINOGEN ICITY
January 1992
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
GLYCIDALDEHYDE 000765-34-4
HINE CH, RJ GUZMAN, MK DUNLAP. R LIMA AND GS LOQUVAM 1961 STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE ARCH ENVIRON HEALTH
2 23-30
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR GLYCIDALDEHYDE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, National Center for Environmental Assessment. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC
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The uncertainty factor used in calculating the [RfC] or [RfD] reflects scientific
judgment regarding the various types of data used to estimate [RfC] or [RfD] values.
An uncertainty factor of 10 is usually used to account for variation in human sensitivity
among populations. An additional 10-fold factor is usually used to account for each of
the uncertainties assumed when extrapolating from animal data to humans, when
extrapolating from a LOAEL to a NOAEL, and when extrapolating from subchronic to
chronic exposure. In order to reflect professional assessment of the uncertainties of the
study and the data base not explicitly addressed by the above uncertainty factors (e.g.,
completeness of the overall data base), an additional uncertainty factor or modifying
factor ranging from greater than 0 to less than or equal to 10 is applied. The default
value for this modifying factor is 1.
For chemicals for which a chronic [RfC] or [RfD] is presented in Tables 1 and 2,
a subchronic [RfC] or [RfD] is usually derived, if not previously derived in the Agency
documents that originally addressed the chemical. Subchronic toxicity values are not
evaluated by the RfD/RfC Work Group. The subchronic [RfC] or [RfD] is derived in
either of two ways: 1) If an uncertainty factor was used to account for extrapolation
from subchronic to chronic exposure in the derivation of the chronic [RfC] or [RfD], then,
the subchronic [RfC] or [RfD] is derived from the same benchmark concentration or
dose without applying the uncertainty factor for subchronic to chronic exposure extrapo-
lation. 2) If the chronic [RfC] or [RfD] was derived without use of an uncertainty factor
for extrapolating from subchronic to chronic exposure (e.g., if chronic data were
available), then, the chronic [RfC] or [RfD] is adopted as the subchronic [RfC] or [RfD].
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Tables 1 and 2 list the uncertainty factor and modifying factor, multiplied
together, to form a single factor under the heading "Uncertainty Factor." For example,
the uncertainty factor of 3000 listed for the chronic inhalation [RfC] for Glycidaldehyde
reflects an uncertainty factor of 1000 (10 for human sensitivity, 10 for extrapolation from
animal to human, and 10 for extrapolation from subchronic to chronic) and a modifying
factor of 3 (for an inadequate data base); the uncertainty factor of 500 listed for the
subchronic oral [RfD] for cyanide reflects an uncertainty factor of 100 (10 for human
sensitivity, and 10 for extrapolation from animal to human) and a modifying factor of 5
(to account for tolerance to cyanide when ingested by food rather than administration
by gavage or by drinking water).
[RfC] and [RfD] values are specific for the route of exposure for which they are
listed on Tables 1 and 2. In the few instances where an [RfD] or [RfC] has been
determined from another exposure route, route-to-route extrapolation is indicated by a
footnote.
The current methodology for the derivation of inhalation RfCs is detailed in the
document, "Interim Methods for Development of Inhalation Reference Doses" (U.S.
EPA, 1990, EPA/600/8-88/066F, NTIS PB90-145723). These methods are different
from those used for oral RfDs because of (1) the dynamics of the respiratory system
and its diversity across species, and (2) differences in the physicochemical properties of
contaminants (such as the size and shape of a particle or whether the contaminant is
an aerosol or a gas). Parameters such as deposition, clearance mechanisms and the
physicochemical properties of the inhaled agent are considered in the determination of
the effective dose delivered to the target organ.
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An RfC value calculated using this interim methodology is generally reported as
a concentration in air (mg/m3), although it may be converted to a corresponding inhaled
dose (mg/kg/day) by dividing by 70 kg (an assumed human body weight), multiplying by
20 m3/day (an assumed human inhalation rate), and adjusting by an appropriate
absorption factor. This conversion, however, may often be technically incorrect, and
the appropriateness of doing this must be evaluated on a case-by-case basis. It is
recommended that HEAST users that plan to use this technique read a further
discussion of the difficulties inherent in this dose conversion that can be found in
Appendix A, Section II: Dose Conversions On HEAST.
Inhalation [RfC] values reported in HEAs and early HEEDs that were finalized
prior to the implementation of the interim methods were calculated using methods
similar in concept to those used for oral [RfDJs. These values are reported both as a
concentration in air (in mg/m3 for continuous, 24 hours/day exposure) under the column
[RfC], and as a corresponding inhaled dose (in mg/kg/day) in the footnotes called,
Chronic (Subchronic) [RfC] Comment. These chemicals are listed in Table 2: Alternate
Methods - Subchronic and Chronic Toxicity (Other Than Carcinogenicity).
[RfD] values for oral exposure are reported as mg/kg/day. An oral [RfD] value
can be converted to a corresponding concentration in drinking water, assuming human
body weight of 70 kg and water consumption of 2 L/day, as follows:
mg/L in water = °ral [RfD] (in m9/kg/day) x 70 kg
2 L/day
The [RfC] or [RfD] is used as a reference point for gauging the potential effects
of other exposures. Usually, exposures that are less than the [RfC] or [RfD] are not
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likely to be associated with health risks. As the frequency of exposures exceeding the
[RfC] or [RfD] increases and as the size of the excess increases, the probability
increases that adverse health effects may be observed in a human population.
Nonetheless, a clear distinction that would categorize all exposures below the [RfC] or
[RfD] as "acceptable" (risk-free) and all exposures in excess of the [RfC] or [RfD] as
"unacceptable" (causing adverse effects) cannot be made. In addition, [RfC] and [RfD]
values, and particularly those with limitations in the quality or quantity of supporting
data, are subject to change as additional information becomes available.
When [RfC] or [RfD] values are listed in Tables 1 or 2 for chemicals that are
carcinogens, a footnote will refer to Table 3 if additional information concerning
carcinogenicity is available in that table. [RfC] and [RfD] values that have been derived
for carcinogens are based on noncancer endpoints only and should not be assumed to
be protective against carcinogenicity.
TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
Chemicals are listed in Table 2 when the [RfD] or [RfC] was derived from
alternative methods that were not practiced by the RfD/RfC Work Group. The table
consists primarily of inhalation [RfC] values determined from methodology that does not
follow the interim inhalation methods adopted by the Agency, and [RfC] or [RfD] values
based on route-to-route extrapolation with inadequate pharmacokinetic and toxicity
data. A footnote is added to each chemical to provide a short explanation of the
specific methodology used in calculating these provisional toxicity values. Most of
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these toxicity values were formerly listed in Table 1. In some instances, the chemical
may be listed in both Tables 1 and 2 if the chemical has more than one toxicity value.
Table 2 follows the same format as Table 1 (refer to Figure 1).
TABLE 3: CARCINOGENICITY
In assessing the carcinogenic potential of a chemical, the Human Health
Assessment Group (HHAG) of EPA classifies the chemical into one of the following
groups, according to the weight of evidence from epidemiologic and animal studies:
Group A - Human Carcinogen (sufficient evidence of carcino-
genicity in humans)
Group B - Probable Human Carcinogen (B1 - limited evidence
of carcinogenicity in humans; B2 - sufficient evidence
of carcinogenicity in animals with inadequate or lack
of evidence in humans)
Group C - Possible Human Carcinogen (limited evidence of
carcinogenicity in animals and inadequate or lack of
human data)
Group D - Not Classifiable as to Human Carcinogenicity
(inadequate or no evidence)
Group E - Evidence of Noncarcinogenicity for Humans (no
evidence of carcinogenicity in adequate studies).
These classifications are shown under [EPA Group] on Table 3.
Quantitative carcinogenic risk assessments are performed for chemicals in Groups
A and B, and on a case-by-case basis for chemicals in Group C. Cancer [slope factors]
(formerly called cancer potency factors in the Superfund Public Health Evaluation
Manual) are estimated through the use of mathematical extrapolation models, most
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commonly the linearized multistage model, for estimating the largest possible linear
slope (within the 95% confidence limit) at low extrapolated doses that is consistent with
the data. The [slope factor] or risk is characterized as an upper-bound estimate, i.e.,
the true risk to humans, while not identifiable, is not likely to exceed the upper-bound
estimate and in fact may be lower.
Quantitative carcinogenic estimates listed in Table 3 include the following:
[slope factor] = risk per unit dose = risk per mg/kg/day
[unit risk] for inhalation exposure = risk per concentration unit in air
= risk per ug/m3
[unit risk] for oral exposure = risk per concentration unit in water =
risk per ug/L
[Unit risk] estimates for inhalation and oral exposure can be calculated by dividing the
appropriate [slope factor] by 70 kg and multiplying by the inhalation rate (20 m3/day) or
the water consumption rate (2 L/day), respectively, for risk associated with unit
concentration in air or water. Hence,
risk per ug/m3 (air) = (risk per mg/kg/day) x __ 1 x 20 m3/day x 10~3 (mg/ug)
70kg
risk per ug/L (water) = (risk per mg/kg/day) x 1 x 2 L/day x 10~3 (mg/ug)
70kg
Quantitative estimates of carcinogenic risk are listed under [Unit Risk] or [Slope Factor]
in Table 3. Information on the study and data set used for estimation of the [slope
factor] is given in the other columns of Table 3.
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In Table 3, the information listed is the following:
Chemical
Route
Species
Experiment Length
Target
Cancer
[EPA Group]
Oral [Slope Factor]
Inhalation [Slope Factor]
Oral [Unit Risk]
Inhalation [Unit Risk]
Reference
Chemical Name/CASRN
Route of Administration
Tested Species
Length of Exposure
Target Organ(s) Affected at Critical Level
Tumors Observed at Critical Level (Not
Specified if More Than One Type of Tumor)
EPA Classification by Weight of Evidence
Risk Per Unit Dose
Risk Per Unit Dose
Risk Per Concentration Unit in Water
Risk Per Concentration Unit in Air
Reference Identification Number for All Toxicity
Values on the Same Line.
An example of this information is shown in Figure 2, HEAST Table 3:
Chemical
Route
Species
Experiment Length
Target
Cancer
[EPA Group]
Oral [Slope Factor]
Inhalation [Slope Factor]
Oral [Unit Risk]
Inhalation [Unit Risk]
Reference
DIMETHYLHYDRAZINE, 1,2-/000077-78-1
ORAL: DRINKING WATER
MOUSE
LIFETIME
CARDIOVASCULAR SYSTEM
TUMORS
B2
3.7E+1 (MG/KG/DAY)-1
3.7E+1 (MG/KG/DAY)-1
1.1E-3(UG/L)-1
1.1E-2(UG/CUM)-1
009993
Notice that the inhalation values for 1,2-Dimethylhydrazine was extrapolated from the
oral data.
Also given in Figure 2 is an example of the References for Table 3 for the same
chemical. The reference is identified by the chemical name (Dimethylhydrazine, 1,2-),
the CASRN (000077-78-1), and the reference number that links it with the toxicity
values (009993).
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FIGURE 2
Example Data and References for Carcinogenicity
HEAST TABLE 3: CARCINOGENICITY
EXPERIMENT LENGTH
CHEMICAL ROUTE SPECIES TARGET CANCER
OIMETHYLHYDRAZINE.1.2- 000077-78-J
ORAL DRINKING LIFETIME
WATER
MOUSE CARDIOVASCULAR TUMORS
SYSTEM
Inhalation [Slope] Comment BASED ON ROUTE TO ROUTE EXTRAPOLATION
[SLOPE FACTOR]
[EPA ORAL INHALATION
[UNIT RISK]
ORAL INHALATION REFERENCE
GROUP] (mg/kg/dayVdng/kg/day)'1 (ug/L) ' (ug/cu m) '
B2
3.7E+1
1.1E-3 1 1E-2 009993
January 1992
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY
tn
DIMEfHYLHYDRAZINE, 1,2- 000077-78-1
TOTH B AND K PATEL 1982 CARCINOGENICITY DOSE-RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF 1,2-DIMETHYLHYDRAZINE
DI-HVDROCHLQR!DE IN MICE I LIGHT AND TRANSMISSION ELECTRON MICROSCOPIC STUDY OF COLONOIC NEOPLASMS AM J OF PATH
84 69-86
US EPA 1988 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
January 1992
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHFP INFORMATION IRIS USER SUPPORT (513) 569-7254.
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Quantitative carcinogenic estimates are specific for the route of exposure for which
they are listed on Table 3. Footnotes are used to indicate those instances in which the
values for inhalation or oral exposure are based on extrapolation from another route of
exposure. The route-to-route conversion required to present inhalation [slope factors]
in the units of mg/kg/day is considered by the CRAVE Work Group to be technically
incorrect. It is recommended that HEAST users who plan to use this information read a
further discussion of the difficulties inherent in this dose conversion which can be found
in Appendix A, Section II: Dose Conversions On HEAST.
To estimate risk-specific concentrations in air from the [unit risk] in air as presented
in Table 3, the specified level of risk is divided by the [unit risk] for air. Hence, the air
concentration (in M9/m3) corresponding to an upper-bound increased lifetime cancer risk
of 1x10'5 is calculated as follows:
. . 1xfO
in air =
[unit risk] in (pg/m3)"1
To estimate risk-specific concentrations in drinking water from the oral [slope factor]
values presented in Table 3, the specified level of risk is multiplied by 70 kg and divided
by the [slope factor] times 2 L/day. Hence, the water concentration corresponding to an
upper-bound increased lifetime cancer risk of 1x10'5 is calculated as follows:
mg/L in water - ^10^ x 70 kg
[slope factor] in (mg/kg/day)~1 x 2 Uday
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USER'S GUIDE: RADIONUCLIDE CARCINOGENICITY
Introduction
EPA classifies all radionuclides as Group A carcinogens. HEAST Table 4 lists
ingestion, inhalation and external exposure cancer slope factors for radionuclides in
units of picocuries (pCi).1 Ingestion and inhalation slope factors are central estimates in
a linear model of the age-averaged, lifetime attributable radiation cancer incidence
(fatal and nonfatal cancer) risk per unit of activity inhaled or ingested, expressed as
risk/pCi. External exposure slope factors are central estimates of lifetime attributable
radiation cancer incidence risk for each year of exposure to external radiation from
photon-emitting radionuclides distributed uniformly in a thick layer of soil, and are
expressed as risk/yr per pCi/gram soil. When combined with site-specific media
concentration data and appropriate exposure assumptions2, slope factors can be used
to estimate lifetime cancer risks to members of the general population due to
radionuclide exposures.
1Slope factors are reported in Table 4 in the customary units of picocuries (1 pCi = 10"12 curies (Ci) =
3.7x10~2 nuclear transformations per second) for consistency with the system used for radionuclides in the
IRIS database. If required, slope factors in Table 4 can be converted into the International System (SI)
units of becquerels (1 Bq = 1 nuclear transformation per second) by multiplying each inhalation, ingestion,
or external exposure value by 27.03. Users can calculate cancer risks using slope factors expressed in
either customary units or SI units with equivalent results, provided that they also use air, water and soil
concentration values in the same system of units.
2Agency standardized default exposure scenarios and assumptions for use in baseline risk assessment
are provided in EPA (1991), Risk Assessment Guidance for Superfund, Vol. I, Human Health Evaluation
Manual, Supplemental Guidance: "Standard Default Exposure Factors" (Interim Final), Office of
Emergency and Remedial Response, OSWER Directive 9285.6-03. [NTIS order number: PB 91-921314,]
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Intended Users and Applications
HEAST users include individuals from the EPA, other Federal agencies, States and
contractors who are responsible for the identification, characterization and remediation
of sites contaminated with radioactive materials. Radionuclide slope factors are
calculated by EPA's Office of Radiation and Indoor Air (ORIA) to assist HEAST users
with risk-related evaluations and decision-making at various stages of the remediation
process. During site assessment, for example, slope factors are used in EPA's Hazard
Ranking System (MRS) to assign toxicity factor values to radionuclides to calculate site
scores. During the remedial investigation and feasibility study (RI/FS), slope factors are
used to determine baseline site risk, to develop preliminary remediation goals, and to
evaluate cleanup alternatives. For further examples on the application of radionuclide
slope factors in risk evaluations, users are referred to the following EPA documents:
Hazard Ranking System (HRS), Federal Register (55 FR 515320), December
1990.
Risk Assessment Guidance for Superfund; Volume I - Human Health
Evaluation Manual (RAGS/HHEM), Part A, Baseline Risk Assessment
(EPA/540/1-89/002).
RAGS/HHEM Part B, Development of Risk-Based Preliminary Remediation
Goals (OSWER Directive 9285.7-01 B). [NTIS order number: PB 92-963333.]
RAGS/HHEM Part C, Risk Evaluation of Remedial Alternatives (OSWER
Directive 9285.7-01 C). [NTIS order number. PB 92-963334.]
Copies of RAGS/HHEM Parts A, B and C are available to the public from the
National Technical Information Service (NTIS) at (703) 487-4650. Copies are available
to EPA staff by calling the Superfund Documents Center at (703) 603-8917.
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Radiation Effects
Ionizing radiation has been shown to be a carcinogen, a mutagen, and a teratogen.
Radiation can induce cancers in nearly any tissue or organ in both humans and
animals, and the probability of cancer induction increases with increasing radiation
dose. Cancer induction is a delayed response that has been documented extensively
in epidemiological studies of Japanese atomic bomb survivors, underground uranium
miners, radium dial painters, and patients subject to a variety of radiation treatments.
Laboratory animal research and mammalian tissue culture studies have provided
additional, collaborative data.
Mutagenic effects of radiation have been demonstrated primarily in animal and
tissue culture studies; limited data from studies of A-bomb survivors indicate that
humans may be as sensitive or less sensitive than animals to radiogenic mutagenicity.
Data are also available from both human and animal studies on the teratogenic effects
of radiation. These data show that the fetus is most sensitive to radiation injury during
the early stages of organ development (between 8 and 15 weeks for the human fetus).
Resultant radiation-induced malformations depend on which cells are most actively
differentiating at the time of exposure.
EPA classifies all radionuclides as Group A carcinogens, based on their property of
emitting ionizing radiation and on the extensive weight of evidence provided by
epidemiological studies of radiogenic cancers in humans. At Superfund radiation sites,
EPA generally evaluates potential human health risks based on the radiotoxicity, i.e.,
adverse health effects caused by ionizing radiation, rather than on the chemical toxicity,
of each radionuclide present. These evaluations consider the carcinogenic effects of
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radionuclides only. In most cases, cancer risks are limiting, exceeding both mutagenic
and teratogenic risks.
Derivation of Radionuclide Slope Factors
EPA's Office of Radiation and Indoor Air (ORIA) calculates radionuclide slope factor
values using health effects data and dose and risk models from a number of national
and international scientific advisory commissions and organizations, including the
National Academy of Sciences (MAS), the National Council on Radiation Protection and
Measurements (NCRP), the United Nations Scientific Committee on the Effects of
Atomic Radiation (UNSCEAR), and the International Commission on Radiological
Protection (ICRP). A detailed discussion of ORIA's approach and assumptions is
provided in Estimating Radiogenic Cancer Risks (EPA 402-R-93-076).
Radionuclide slope factors are calculated for each radionuclide individually, based
on its unique chemical, metabolic and radioactive properties. The calculation uses
dose estimates from EPA's computer code RADRISK3, vital statistics from the U.S.
Decennial Life Tables for 1979-1981 (described in EPA 402-R-93-076), and cancer risk
estimates based largely on the results of the MAS BEIR V report4, ICRP Publication 605,
3Dunning, D.E. Jr., Leggett, R.W., and Yalcinatas, M.G. (1980). "A Combined Methodology for Estimating
Dose Rates and Health Effects from Exposure to Radioactive Pollutants," ORNL/TM-7105.
4National Academy of Sciences (1990). Health Effects of Exposure to Low Levels of Ionizing Radiation.
BEIR V. Committee on the Biological Effects of Ionizing Radiations, National Research Council,
Washington, D.C.
International Commission on Radiological Protection (1991), 1990 Recommendations of the International
Commission on Radiological Protection. ICRP Publication 60, Pergamon Press, New York, NY.
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and U.S. Nuclear Regulatory Commission (NRC) analyses6. Ingestion and inhalation
slope factors for radionuclides account for:
the amount of radionuclide transported into the bloodstream from either the
gastrointestinal (Gl) tract following ingestion, or from the lungs following
inhalation;
the ingrowth and decay of radioactive progeny produced within
the body subsequent to intake;
the distribution and retention of each radionuclide (and its associated progeny,
if appropriate) in body tissues and organs;
the radiation dose delivered to body tissues and organs from the radionuclide
(and its associated progeny, if appropriate); and
the sex, age, and organ-specific risk factors over the lifetime of exposure.
The slope factors are the average risk per unit intake or exposure for an individual
in a stationary population with vital statistics (mortality rates) of the United States in
1980. (The expected lifetime for an individual in this population is about 74 years.)
Consequently, radionuclide ingestion and inhalation slope factors are not expressed as
a function of body weight and time, and do not require corrections for Gl absorption or
lung transfer efficiencies.
NOTE: The Gl absorption values (fj, ICRP lung classifications (D, W, Y) and
radioactive half-lives are provided in HEAST Table 4 for reference only and should
not be used to correct, modify, or in any way adjust radionuclide slope factors or
intake assumptions in risk calculations.
6U.S. Nuclear Regulatory Commission (1991,1993), Health Effects Models for Nuclear Power Plant
Accident Consequence Analysis. NUREG/CR-4214. Addenda documenting the scientific basis for
radiogenic risk models published in 1991 (for low-LET radiation) and 1993 (for alpha radiation). See EPA
402-R-93-076 for discussion of these models.
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External slope factors provide cancer risk estimates per unit exposure to a uniform
radionuclide concentration in soil. These factors, which account for photon energy flux
attenuation and buildup in soil, are calculated for each radionuclide using volume and
surface dose factors derived using the computer code DFSOIL.7
Because of the radiation risk models employed for both internal and external
exposures, slope factors for radionuclides are characterized as central estimates in a
linear model of the age-averaged lifetime total radiation cancer incidence risk per unit
intake or exposure.
About the Information Provided in Table 4
Table 4 lists ingestion, inhalation and external exposure slope factors for principal
radionuclides, and provides key parameter values used in the derivation of slope factor
values. Radionuclides are presented alphabetically by element and atomic weight.
Selected radionuclides and radioactive decay chain products are designated in
HEAST Table 4 with the suffix "+D" (e.g., U-238+D, Ra-226+D, Cs-137+D) to indicate
that cancer risk estimates for these radionuclides include the contributions from their
short-lived decay products, assuming equal activity concentrations (i.e., secular
equilibrium) with the principal or parent nuclide in the environment.8 Decay chains are
identified in Exhibit 1.
7Sjoreen, A.L, Kocher, D.C., Killough, G.G. and Miller C.W. (1984). "MLSOIL and DFSOIL - Computer
Codes to Estimate Effective Ground Surface Concentrations for Dose Computations," ORNL-5974, Oak
Ridge National Laboratory, Oak Ridge, TN.
"There is one exception to the assumption of secular equilibrium. For the inhalation slope factor for Rn-
222+D reported in HEAST Table 4, ORIA assumes a 50% equilibrium value for radon decay products (Po-
218, Pb-214, Bi-214 and Po-214) in air.
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In most cases, site-specific analytical data should be used to establish the actual
degree of equilibrium between each parent radionuclide and its decay products in each
media sampled. However, in the absence of empirical data, the "+D" values for
radionuclides should be used unless there are compelling reasons not to. For example,
the external slope factors for Cs-137 and Cs-137+D are 0.0 and 2x10"6 (risk per year
per pCi/gram), respectively. The value for Cs-137+D is higher because it includes the
risk contribution from cesium's short-lived gamma-emitting decay product Ba-137m
(half-life, 25.5 minutes) which, under most environmental conditions, will be in secular
equilibrium with Cs-137.
Note that there may be circumstances, such as long disposal times or
technologically enhanced concentrations of naturally occurring radionuclides, that may
necessitate the combination of the risks of a parent radionuclide and its decay products
over several contiguous subchains. For example, Ra-226 soil analyses at a site might
show that all radium decay products are present in secular equilibrium down to stable
Pb-206 (See Exhibit 1). In this case, Ra-226 risk calculations should be based on the
ingestion, inhalation and external exposure slope factors for the Ra-226+D subchain,
plus the ingestion, inhalation and external exposure factors for the Pb-210+D subchain.
For actual sites, users should consult with a health physicist or radiochemist (1) to
evaluate the site-specific analytical data to determine the degree of equilibrium between
parent radionuclides and decay members of contiguous decay chains and (2) to assist
in the combination of appropriate slope factor values. For health physics and
radioanalytical support, HEAST users may contact EPA's Regional Radiation Program
Managers, ORIA's National Air and Radiation Environmental Laboratory (NAREL) in
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Montgomery, Alabama, ORIA's Las Vegas Laboratory (ORIA-LV) in Las Vegas,
Nevada, or the ORIA contact at EPA headquarters in Washington, D.C., listed in
Exhibit 2.
A Chemical Abstract System Reference Number (CASRN) is assigned to each
radionuclide for identification and reporting accuracy during risk assessments, and
radioactive half-lives are provided for reference.
The designations "D", "W", and "Y" presented in Table 4 under the heading "ICRP
Lung Class" in the tables refer to the lung clearance times for inhaled particulate
radionuclides, expressed as days (D), weeks (W), or years (Y), as recommended by the
International Commission on Radiological Protection (ICRP). Gaseous radionuclides,
e.g., Rn-222, are designated with an asterisk ("*"). "Gl Absorption Factors, f/' are the
fractional amounts of each radionuclide that may be absorbed from the gastrointestinal
(Gl) tract into blood following an oral intake. The ICRP lung clearance classifications
and Gl absorption factors provided in Table 4 are the default values that EPA used to
calculate radionuclide slope factors for inhalation and ingestion exposures, respectively.
These factors are provided for reference only (see the Note Box).
Where to Address Questions About Radionuclide Slope Factors:
EPA continuously reviews the scientific literature on radiation effects to ensure that
the Agency's risk assessment methodologies are consistent with current models and
assumptions. As risk methodologies are refined, EPA will revise and update the slope
factors in Table 4.
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HEAST users with questions about radionuclide slope factor values and their use in
radiation risk assessments should contact Michael Boyd of the Remedial Guidance
Section of the Radiation Assessment Branch of ORIA at (202) 233-9395. Written
requests for assistance can be sent by fax to (202) 233-9650.
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Exhibit 1. Radionuclide Decay Chains Considered Explicitly in HEAST Table 49
Principal Radionuclide
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Exhibit 1. Radionuclide Decay Chains Considered Explicitly in HEAST Table (Continued)
Principal Radionuclide ^
Nuclide
Sb-125+D
Sr-90+D
Th-228+D
Th-229+D
U-235+D
U-238+D
Half-life (yr)
3
29
2
7.3 x103
7.0 x108
4.5 x109
Associated Decay Chain *b'
Te-125m (22.8%, 58 d)
Y-90 (64 h)
Ra-224 (4 d)
Rn-220 (56 s)
Po-216 (0.2 s)
Pb-212(11 h)
Bi-212 (61 min)
[Po-212 (64.07%, 0.3 us)
TI-208 (35.93%, 3 min)]
Ra-225(15d)
Ac-225(10d)
Fr-221 (5 min)
At-217(32ms)
Bi-213(46min)
[Po-213(97.8%, 4us)
TI-209 (2.2%, 2 min)]
Pd-209 (3 h)
Th-231 (26 h)
Th-234 (24 d)
[Pa-234m (99.80%, 1 min)
Pa-234 (0.33%, 7 h)]
Terminal Nuclide or Radionuclide 'c'
Nuclide
Te-125
Zr-90
Pb-208
Bi-209
Pa-231
U-234
Half-life (yr)
*
*
*
*
3.3x10"
2.4 x106
(a) Radionuclides with half-lives greater than six months. "+D" designates principal radionuclides with associated
decay chains.
(b) The chain of decay products of a principal radionuclide extending to (but not including) the next principal
radionuclide or a stable radionuclide. Half-lives are given in parentheses. Branches are indicated by square
brackets with branching percentages in parentheses.
(c) The principal radionuclide or stable nuclide that terminates an associated decay chain. Stable nuclides are
indicated by an asterisk (*) in place of a half-life.
(d) A hyphen indicates that there are no associated decay products.
-37-
-------
Exhibit 2. EPA Radition Program Managers
NAME/ADDRESS
PHONE#
FAX#
Jim Cherniack
U.S. EPA/Region 1 (CPT)
JF Kennedy Federal Bldg.
Boston, MA 02203
(617)565-3234
(617)565-4940
Paul A. Giardina
U.S. EPA/Region 2
290 Broadway 28th Floor
New York, NY 10007-1866
(212)637-4010
(212)637-4942
Aquanetta Dickens
U.S. EPA/Region 3 (3AT32)
841 Chestnut Building
Philadelphia, PA 19107
(215)566-2080
(215)566-2134
Paul Wagner
U.S. EPA/Region 4
61 Forsyth St.
Atlanta, GA 30303
(404)562-9100
(404) 562-9095
Jack Barnette
U.S. EPA/Region 5 (AE-17J)
77 West Jackson Boulevard
Chicago, IL 60604
(312)886-6175
(312) 353-8289
Steve Vargo
U.S. EPA/Region 6 (6PD-T)
1445 Ross Avenue
Dallas, TX 75202-2733
(214)665-6714
(214)665-6762
Robert Dye
U.S. EPA/Region 7 (RALI)
726 Minnesota Avenue
Kansas City, KS 66101
(913)551-7605
(913)551-7065
Milton W. Lammering
U.S. EPA/Region 8 (P2-TX)
999 18th St. Suite 500
Denver, CO 80202-2466
(303)312-6147
(303)312-6044
Michael S. Bandrowski
U.S. EPA/Region 9 (AIR-6)
75 Hawthorn Street
San Francisco, CA 94105
(415)744-1048
(415)744-1073
Jerry Leitch
U.S. EPA/Region 10 (OAQ-107)
1200 Sixth Avenue 10th Floor
Seattle, WA 98101
(206) 553-7660
(206) 553-0404
-38-
-------
NAME/ADDRESS
PHONE #
FAX*
Samuel T. Windham, Director
Office of Radiation and Indoor Air
National Air and Radiation Environmental
Laboratory (NAREL)
U.S. EPA
540 South Morris Avenue
Montgomery, AL 36115-2601
(334) 270-3400
(334) 270-3454
Jed Harrison, Director
Office of Radiation and Indoor Air
Las Vegas Laboratory
EPA Facilities
P.O. Box98517
Las Vegas, NV 89193-8517
(702) 798-2476
(702) 798-2465
Michael Boyd
Office of Radiation and Indoor Air (6603J)
U.S. EPA
401 M Street, SW
Washington. DC 20460
(202) 233-9395
(202) 233-9650
-39-
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE
ROUTE
ACENAPHTHENE
NOAEL 175 MG/KG/DAY
ORAL: GAVAGE
EXPERIMENT LENGTH TARGET
000083-32-9
MOUSE
90 DAYS LIVER
CRITICAL EFFECT
HEPATOTOXICITY
Subchrom'c Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (tng/cu m) (ma/kg/dav)
UF UF UF UF
6E-1
300
IRIS
010165
ACENAPTHYLENE 000208-96-8
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005202
ACEPHATE
LOAEL 2 PPM
ORAL DIET
030560-19-1
RAT
13 WEEKS
BRAIN
DECREASED CHOLINESTERASE
ACTIVITY
GENERAL COMMENT ALSO SEE HEAST TABLE 3. CARCINOGENICITY
4E-3
30
IRIS 005833
ACETONE
NOEL 100 MG/KG/DAY
ORAL- GAVAGE
000067-64-1
RAT
90 DAYS
LIVER
KIDNEY
KIDNEY
INCREASED WEIGHT
INCREASED WEIGHT
NEPHROTOXICITY
1E+0
100
IRIS 005204
ACETONE CYANOHYDRIN /
NOAEL. 8 75 MG/(KG-DAY)
ORAL GAVAGE
(2-METHYLLACTONITRILE)
RAT
90 DAYS LIVER
000075-86-5
INCREASED RELATIVE WEIGHT
8E-3
300
8E-4
3000
005776
SUBCHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2' ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2' ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254.
1-1
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(mg/cu m) Onq/kq/dav)
UF UF
Chronic
[RfC] [RfD]
(mg/cu m) (mq/ko/dav)
UF UF
REFERENCE
ACETONITRILE
NOAEL 100 PPM
INHALATION-
INTERMITTENT
000075-05-8
MOUSE
92 DAYS
ERYTHROCYTES
BLOOD
LIVER
DECREASED CELL COUNT
DECREASED HEMATOCRIT
HEPATIC LESIONS
6E-2
300
IRIS
005210
SUBCHRONIC [RfC] COMMENT- ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5.
CHRONIC [RfC] COMMENT. ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5 UNDER REVIEW. CURRENT NUMBER SUBJECT TO
CHANGE.
ACETOPHENONE 000098-86-2
NOAEL 10,000 PPM RAT
ORAL- DIET 17 WEEKS
NONE OBSERVED
1E+0
300
IRIS 005212
010874
CHRONIC [RfC] COMMENT; THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP
ACROLEIN 000107-02-8
NOAEL 15 6 MG/KG/DAY RAT
ORAL. WATER 90 DAYS
GENERAL COMMENT ALSO SEE HEAST TABLE 3 CARCINOGENICITY
2E-2
1000
IRIS
010390
010856
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-2
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
ACRYLAMIDE
NOEL 0.2 MG/KG/DAY RAT
ORAL. DRINKING 90 DAYS
WATER
TARGET
000079-06-1
NERVE
CRITICAL EFFECT
DAMAGE
Subchromc Chronic
[RfC] [RfO] [RfC] [RfO] REFERENCE
(ro/cu m) (mq/kq/dav) (mo/cu m) (ma/kq/dav)
UF UF UF UF
2E-3
100
IRIS
GENERAL COMMENT. ALSO SEE HEAST TABLE 3- CARCINOGENICITY
IRIS
005835
010876
CHRONIC RfC COMMENT- THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (09/20/90) BY THE RfO/RfC WORK GROUP
ACRYLIC ACID
NOAEL 53 HG/KG/DAY
ORAL DRINKING
WATER
000079-10-7
RAT
2 GENERATION WHOLE BODY
DECREASED PUP WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfO ON IRIS WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
5E-1
100
IRIS
005836
LOAEL 5 PPM MOUSE
INHALATION- 13 WEEKS
INTERMITTENT
NASAL MUCOSA LESIONS
ACRYLONITRILE
NOAEL 1 MG/CKG-DAY) MOUSE
ORAL. GAVAGE 60 DAYS
000107-13-1
TESTES
TESTES
3E-3
100
DECREASED SPERM COUNTS
SEMINIFEROUS TUBULE
DEGENERATION
1E-2
100
IRIS
1E-3
1000
SUBCHRONIC [RfO] COMMENT. THE CHRONIC ORAL [RfO] UNDER REVIEW BY THE RfO/RfC WORK GROUP WAS MODIFIED TO ESTIMATE THE
SUBCHRONIC ORAL [RfD]
GENERAL COMMENT. ALSO SEE HEAST TABLE 3 CARCINOGENICITY
010346
010939
ADIPONITRILE 000111-69-3
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
00515?
MS. ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION- RISl' INFORMATION HOTLINE: (513) 569-7254.
1-3
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfD]
(mq/cu m) (mq/kq/dav)
UF UF
Chronic
[RfC] [RfD] REFERENCE
(mq/cu m) (mg/kq/dav)
UF UF
ALACHLOR
NOEL 1 MG/KG/DAY DOG
ORAL CAPSULE 1 YEAR
015972-60-8
BLOOD
ANEMIA
SITES. MULTIPLE HEMOSIDEROSIS
1E-2
100
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT; ALSO SEE HEAST TABLE 3 CARCINOGENICITY.
ALDICARB
NOAEL 0.01 MG/KG-DAY HUMAN
ORAL ACUTE
000116-06-3
CENTRAL NERVOUS SWEATING
SYSTEM
1E-3
10
IRIS
005837
IRIS
010960
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT. CLINICAL SIGNS OF ACETYL CHOLINESTERASE INHIBITION INCLUDING SWEATING. PINPOINT PUPILS. LEG WEAKNESS. NAUSEA. DIARRHEA
AND OTHER EFFECTS WERE OBSERVED IN THE PRINCIPAL AND SUPPORTING STUDIES.
ALDRIN 000309-00-2
LOAEL 0 025 MG/KG/DAY RAT
ORAL- DIET 2 YEARS LIVER
LESIONS
3E-5
1000
IRIS
005159
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT- ALSO SEE HEAST TABLE 3. CARCINOGENICITY
ALLIDOCHLOR
GENERAL COMMENT
000093-71-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005838
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION RISK INFORMATION HOTLINE. (513) 569-7?54
1-4
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
ALLYL ALCOHOL 000107-18-6
NOEL 50 PPM RAT
ORAL: DRINKING 15 WEEKS LIVER
WATER KIDNEY
CRITICAL EFFECT
EFFECTS
EFFECTS
Subchronic Chronic
[RfC] [RfD] [RfCl [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (mg/cu m) (mg/kq/dav)
UF UF UF UF
5E-2
100
IRIS
005839
ALLYL CHLORIDE
NOAEL 17 MG/CU M
INHALATION
INTERMITTENT
000107-05-1
RABBIT
5 MONTHS
NERVOUS SYSTEM NEUROTOXICITY
GENERAL COMMENT: ALSO SEE HEAST TABLE 3- CARCINOGENICITY
1E-2
300
IRIS
010369
ALUMINUM 007429-90-5
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005162
ALUMINUM PHOSPHIDE
NOAEL 0.43 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
020859-73-8
WHOLE BODY
UNSPECIFIED
ALTERED WEIGHT
ALTERED CLINICAL PARAMETERS
4E-4
100
IRIS
010255
AMETRYN
NOEL 10 MG/KG/DAY
ORAL. GAVAGE
000834-12-8
RAT
13 WEEKS
LIVER
EFFECTS
AMINO-2-NAPHTHOL, 1- 002834-92-6
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
9E-2
100
IRIS
005841
005842
AMINO-2-NAPHTOL HYDROCHLORIDE, 1- 001198-27-2
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005843
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254
1-5
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DQSE SPECIES
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(iro/cu m) (ma/kq/dav)
UF UF
Chronic
[RfC] [RfD] REFERENCE
(mq/cu m) (mg/kq/dav)
UF UF
AMINOPHENQL, M-
NOAEL 1300 PPM
ORAL: DIET
000591-27-5
RAT
13 WEEKS WHOLE BODY
THYROID
ALTERED WEIGHT
ALTERED WEIGHT
7E-1
100
7E-2
1000
005844
AMINOPHENOL 0- 000095-55-6
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT,
005845
AMINOPHENOL, P-
GENERAL COMMENT-
000123-30-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT,
005846
AMINOPYRIDINE, 4-
NOAEL 3 PPM
ORAL: DIET
000504-24-5
RAT
90 DAYS LIVER
BRAIN
INCREASED WEIGHT
INCREASED WEIGHT
2E-4
1000
2E-5
10000
AMMONIA
NOAEL 34 MG/L
ORAL DRINKING
WATER
HUMAN
007664-41-7
SENSORY
TASTE THRESHOLD
34 MG/L
1
34 MG/L
1
005166
SUBCHRONIC [RfD] COMMENT' GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD
SAFE CONCENTRATION MAY BE HIGHER. BUT DATA ARE INADEQUATE TO ASSESS
CHRONIC [RfD] COMMENT. GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD.
SAFE CONCENTRATION MAY BE HIGHER, BUT DATA ARE INADEQUATE TO ASSESS.
NOAEL 6 4 MG/CU M
INHALATION:
INTERMITTENT
HUMAN
NASAL CAVITY
LUNGS
LUNGS
RHINITIS
PNEUMONIA
LESIONS
1E-1
30
IRIS
010392
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
1-6
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfD]
(mg/cu m) (mq/kq/dav)
UF UF
Chrome
[RfC] [RfD]
(mg/cu m) (mg/kq/dav)
UF UF
July 1997
REFERENCE
ANILINE
NOAEL 19 MG/CU M
INHALATION:
INTERMITTENT
000062-53-3
MOUSE
20-26 WEEKS SPLEEN
RAT
20-26 WEEKS
GUINEA PIG
20-26 WEEKS
SPLEEN
SPLEEN
PATHOLOGY
PATHOLOGY
PATHOLOGY
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
1E-2
300
IRIS
010370
ANTHRACENE
NOEL 1000 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS
000120-12-7
NONE OBSERVED
3E+0
300
IRIS
CHRONIC [RfC] COMMENT THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP
010166
010964
ANTIMONY PENTOXIDE
LOAEL 0 46 MG/KG/DAY
ORAL: DRINKING
WATER
001314-60-9
RAT
LIFETIME
WHOLE BODY
BLOOD
INCREASED MORTALITY
ALTERED CHEMISTRIES
5E-4
1000
5E-4
1000
005174
SUBCHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254.
1-7
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE SPECIES
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfD]
(mo/cu in) (m/kQ/dav)
UF UF
Chronic
[RfC] [RfD]
(mq/cu m) (inq/kq/dav)
UF UF
REFERENCE
ANTIMONY POTASSIUH TARTRATE
LOAEL 0.91 MG/KG/DAY RAT
ORAL. DRINKING LIFETIME
WATER
000304-61-0
WHOLE BODY
BLOOD
INCREASED MORTALITY
ALTERED CHEMISTRIES
9E-4
1000
9E-4
1000
005234
SUBCHRONIC [RfD] COMMENT- CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
CHRONIC [RfD] COMMENT' CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT,
ANTIMONY TETROXIDE
LOAEL 0 44 MG/KG/DAY
ORAL DRINKING
WATER
RAT
LIFETIME
001332-81-6
WHOLE BODY
BLOOD
INCREASED MORTALITY
ALTERED CHEMISTRIES
4E-4
1000
4E-4
1000
005238
SUBCHRONIC [RfD] COMMENT. CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
ANTIMONY TRIOXIDE
LOAEL 0.42 MG/KG/DAY
ORAL DRINKING
WATER
001309-64-4
RAT
LIFETIME
WHOLE BODY
BLOOD
INCREASED MORTALITY
ALTERED CHEMISTRIES
4E-4
1000
4E-4
1000
005242
SUBCHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
CHRONIC [RfD] COHHENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
BMC
0.87 MG/CU M RAT
INHALATION,
INTERMITTENT
1 YEAR
LUNG
LUNG
PULMONARY TOXICITY 2E-4
INTERSTITIAL INFLAMMATION. 30
CHRONIC
IRIS
010974
CHRONIC RfC COMMENT- A BENCHMARK DOSE APPROACH WAS USED RATHER THAN A NOAEL/LOAEL TO DERIVE THE RfC.
SUBCHRONIC [RfC] COMMENT. THE CHRONIC INHALATION RfC IS ADOPTED AS THE INHALATION [RfC]
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. CURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254
l-t
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
ANTIMONY, METALLIC 007440-36-0
LOAEL 0 35 MG SB/KG/DAY RAT
ORAL DRINKING LIFETIME WHOLE BODY
WATER BLOOD
CRITICAL EFFECT
INCREASED MORTALITY
ALTERED CHEMISTRIES
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mq/kq/dav) (mg/cu m) (mg/kq/dav)
UF UF UF UF
4E-4
1000
IRIS
005170
ARAMITE
NOAEL 100 PPM
ORAL DIET
NOAEL 500 PPM
ORAL DIET
000140-57-8
RAT
104 WEEKS LIVER
DOG
52 WEEKS
LIVER
INCREASED WEIGHT
DEGENERATION
GENERAL COMMENT ALSO SEE HEAST TABLE 3 CARCINOGENICITY
1E-1
100
5E-2
100
005850
005849
AROCLOR 1248 012672-29-6
CHRONIC RfD COMMENT THE CHRONIC ORAL RfD IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP
IRIS
010940
AROCLOR 1254
LOAEL 0 005 MG/KG/DAY
ORAL. CAPSULE MONKEY
>5 YEARS
011097-69-1
IMMUNE SYSTEM TOXICITY
5E-5
100
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD]
IRIS 010963
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254
1-9
-------
HEAST TABLE 1: SUBGHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
CHEMICAL DQSE SPECIES
LEVEL EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfD]
(roa/cu m) img/la/day)
UF
UF
Chronic
[RfC] [RfD]
(np/cu m) (iro/kq/dav)
UF UF
REFERENCE
ARSENIC, INORGANIC
NOAEL 0 009 MG/L
ORAL
HUMAN
007440-38-2
SKIN
SKIN
KERATOSIS
HYPERPIGMENTATION
3E-4
3
IRIS
010434
SUBCHRONIC [RfD] COHMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT ALSO SEE HEAST TABLE 3. CARCINOGEN1CITY
ATRAZINE 001912-24-9
NOEL 3.5 MG/KG/DAY RAT
ORAL DIET 2 YEARS WHOLE BODY
DECREASED WEIGHT GAIN
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT ALSO SEE HEAST TABLE 3; CARCINOGENICITY.
BARIUM
NOAEL 0,21 MG/KG/DAY
ORAL WATER
007440-39-3
HUMAN
10 WEEKS CARDIOVASCULAR INCREASED BLOOD PRESSURE
SYSTEM
3.5E-2
100
71-2
3
IRIS
010855
IRIS
010348
SUBCHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfC] COMMENT- ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
BARIUM CYANIDE 000542-62-1
CHRONIC [RfD] COMMENT- THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP
010941
IRIS. EPVS INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION- RISK INFORMATION HOTLINE- (513) 569-7254.
1-10
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIMOGEN1CITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/dav) (iro/cu in) (ma/kg/dav)
UF UF UF UF
BENEFIN
NOAEL 25 MG/KG/DAY DOG
ORAL: DIET 1 YEAR
001861-40-1
ERYTHROCYTE
DECREASED COUNT
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
3E-1
100
IRIS
005852
BENZAL CHLORIDE 000098-87-3
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005853
BENZALDEHYDE
NOEL 200 MG/KG/DAY
ORAL- GAVAGE
000100-52-7
RAT
13 WEEKS
KIDNEY
FORESTOMACH
EFFECTS
LESIONS
1E+0
100
SUBCHRONIC [RfD] CPMMENT THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
IRIS
005854
BENZALDEHYDE CYANOHYDRIN 000532-28-5
GENERAL COMMENT- DATA FOR QUANTITATIVE RISK ASSESSMENT
005781
BENZENE 000071-43-2
SUBCHRONIC [RfC] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300
GENERAL COMMENT ALSO SEE HEAST TABLE 3 CARCINOGENICITY.
BENZENETHIOL / (THIOPHENOL) 000108-98-5
LOAEL 0.1 MG/CKG-DAY) RAT
ORAL- GAVAGE 90 DAYS LIVER
CENTRILOBULAR EOSINOPHILIC
CHANGES
1E-4
1000
1E-5
10,000
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL [RfD] UNDER REVIEW BY THE RfO/RfC WORKGROUP WAS MODIFIED TO ESTIMATE THE
SUBCHRONIC ORAL [RfD]
010942
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254
1-11
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINQGENICITY)
July 1997
DOSE
ROUTE
EXPERIHENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfD]
(na/cu m) (ro/kQ/dav)
UF UF
Chrome
[RfC] [RfD] REFERENCE
(mo/cu m) (mg/ka/dav)
UF UF
BENZIDINE 000092-87-5
LOAEL 2 7 MG/KG/DAY MOUSE
ORAL: DRINKING 33 MONTHS BRAIN
WATER LIVER
CELLULAR CHANGES
CELLULAR CHANGES
3E-3
1000
SUBCHRQN1C [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COHMENT ALSO SEE HEAST TABLE 3- CARCINQGENICITY
IRIS
IRIS
CHRONIC RfC COMMENT- THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (03/28/91) BY THE RfD/RfC WORK GROUP.
BENIO[A]ANTHRACENE 000056-55-3
CHRONIC [RfC] COMMENT THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP
GENERAL COMMENT- ALSO SEE HEAST TABLE 3- CARCINOGENICITY
005830
010877
010965
BENZOIC ACID
NOAEL 312 MG/DAY
ORAL DIET
000065-85-0
HUMAN
NONE OBSERVED
4E+0
1
IRIS
005260
SUBCHRONIC [RfD] COMMENT THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL THE CHRONIC ORAL RfD
WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT. THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL
BENZYL ALCOHOL
LOAEL 286 MG/KG/DAY
ORAL GAVAGE
NOAEL 143 MG/KG/DAY
ORAL, GAVAGE
000100-51-6
RAT
103 WEEKS
RAT
13 WEEKS
FORESTOMACH
WHOLE BODY
EPITHELIAL HYPERPLASIA
DECREASED WEIGHT
3E-1
1000
1E+0
100
005855
005856
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254
1-12
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (ma/kq/dav) im/cu m) (ma/ka/day)
UF UF UF UF
BERYLLIUM 007440-41-7
NOAEL 0 54 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME
WATER
NONE OBSERVED
5E-3
100
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY
BIPHENYL, 1,1' 000092-52-4
NOAEL 50 MG/KG/DAY RAT
ORAL- DIET 700 DAYS KIDNEY
DAMAGE
5E-2
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
IRIS
005262
IRIS
IRIS
005857
010878
CHRONIC RfC COMMENT THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (09/20/90) BY THE RfD/RfC WORK GROUP
BIS(2-CHLOROISOPROPYL) ETHER 039638-32-9
NOAEL 35 8 MG/KG/DAY MOUSE
ORAL DIET 2 YEARS ERYTHROCYTES
DECREASED HEMOGLOBIN
4E-2
1000
IRIS
010257
BIS(2-ETHYLHEXYL) PHTHALATE / (DEHP) 000117-81-7
SUBCHRONIC [RfC] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300.
SUBCHRONIC [RfD] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300
GENERAL COMMENT ALSO SEE HEAST TABLE 3- CARCINOGENICITY
IRIS
010859
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-13
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Chrome
July 1997
Subchronie
CHEMICAL DOSE SPECIES [RfC] [RfD] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mq/cu_m) (mq/kg/davl (mg/cu m) {mq/kq/dav)
UF UF UF UF
BISPHENOL A
NOAEL 750 PPM
ORAL
000080-05-7
RAT
13 WEEKS
WHOLE BODY
DECREASED WEIGHT
6E-1
100
IRIS
005268
005266
BORON TRIFLUORIDE
NOAEL 6 MG/CU H
INHALATION
INTERMITTENT
007637-07-2
RAT
13 WEEKS
KIDNEY
NECROSIS
7E-3
300
7E-4
3000
010395
BORON, ELEMENTAL 007440-42-8
NOAEL 8 8 MG/KG/DAY DOG
ORAL: DIET 2 YEARS TESTIS
LESIONS
IRIS
005272
SUBCHRONIC [RfO] COMMENT. THE SUBCHRONIC ORAL [RfO] WAS REMOVED BECAUSE THE CHRONIC ORAL RfD UPON WHICH IT WAS BASED IS
UNDER REVIEW BY THE RfD/RfC WORK GROUP.
CHRONIC RfD COMMENT: THE CHRONIC ORAL RfD, WHILE STILL ON IRIS, IS BY THE RfO/RfC WORK GROUP
LOAEL 4.5 MG/CU M
INHALATION-
INTERMITTENT
HUMAN
RESPIRATORY
TRACT
BRONCHUS
IRRITATION
BRONCHITIS
2E-2
100
2E-2
100
SUBCHRONIC [RfC] COMMENT THE SUBCHRONIC INHALATION [RfC] IS SPECIFICALLY FOR ANHYDROUS BORAX
CHRONIC [RfC] COMMENT THE CHRONIC INHALATION [RfC] IS SPECIFICALLY FOR ANHYDROUS BORAX
005269
BROMINATED DIBENZO-P-DIOXINS
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT,
005858
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE (513) 569-7254
1-14
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (mg/cu m) (mq/kq/dav)
UF UF UF UF
BROMINATED DIBENZOFURANS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005859
BROMOACETONE 000598-31-2
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005860
BROMOCHLOROETHANES
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005861
BROMODICHLOROMETHANE
LOAEL 17.9 MG/KG/DAY
ORAL GAVAGE
000075-27-4
MOUSE
102 WEEKS KIDNEY
CYTOMEGALY
2E-2
1000
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BROMOETHENE / (VINYL BROMIDE) 000593-60-2
LOAEL 9 7 PPM RAT
INHALATION- 24 MONTHS
INTERMITTENT
LIVER
LIVER
LIVER
HYPERTROPHY
BASOPHILIC FOCI
EOSINOPHILIC FOCI
3E-3
3000
IRIS
005715
IRIS
010929
SUBCHRONIC [RfC] COMMENT- THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC]
GENERAL COMMENT ALSO SEE HEAST TABLE 3. CARCINOGENICITY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-15
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
[p/cu m) (mci/kq/dav) (mg/cu m) (mg/kq/dav)
UF UF UF UF
000075-25-2
NOEL 17.9 MG/KG/DAY RAT
ORAL GAVAGE 13 WEEKS LIVER
EFFECTS
2E-1
100
IRIS
005722
GENERAL COMMENT ALSO SEE HEAST TABLE 3 CARCINOGENICITY
IRIS
CHRONIC RfC COMMENT- THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP
010961
BROMOMETHANE
000074-83-9
IRIS
IRIS
010861
010860
SUBCHRONIC [RfC] COMMENT- CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER- (513) 569-7300
SUBCHRONIC [RfD] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300
BROMOPHENYL PHENYL ETHER, 4- 000101-55-3
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005864
BROHOPHOS
NOAEL 5 MG/KG/DAY
ORAL DIET
002104-96-3
RAT
3 BLOOD
GENERATIONS
LIVER
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
5E-2
100
5E-3
1000
005865.
SUBCHRONIC [RfD] COMMENT. BASED ON A REPRODUCTION STUDY
CHRONIC [RfD] COMMENT BASED ON A REPRODUCTION STUDY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION. RISK INFORMATION HOTLINE. (513) 569-7254.
1-16
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mq/cu m) (ma/ko/dav) (mg/cu m) (ma/kg/dav)
UF UF UF UF
BROMOXYNIL
NOEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
001689-84-5
NONE OBSERVED
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfO WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
2E-2
300
IRIS 005866
BROMOXYNIL OCTANOATE 001689-99-2
NOEL 7.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS NONE OBSERVED
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfO WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
2E-2
300
IRIS
005867
BUSAN 77 031512-74-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005868
BUSAN 90 002491-38-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
BUTANOL. 1-
NOAEL 125 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS
000071-36-3
CENTRAL NERVOUS HYPOACTIVITY
SYSTEM
CENTRAL NERVOUS ATAXIA
SYSTEM
lE+O
100
IRIS
005869
005870
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-17
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
BUTYL BENZYL PHTHALATE, N- 000085-68-7
NOAEL 159 MG/KG/OAY RAT
ORAL: DIET 26 WEEKS LIVER ALTERED WEIGHT
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENiCITY.
Subchronlc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mo/cu m) (mq/ko/dav) (mq/cy IB) (mo/kg/dav)
UF UF UF UF
2E+0
100
IRIS 005616
BUTYLATE 002008-41-5
NOEL 5 MG/KG/OAY DOG
ORAL: CAPSULE 12 MONTHS LIVER INCREASED RELATIVE WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfO WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
5E-2
100
IRIS 005871
BUTYLCHLORIDE, T- 000507-20-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005810
BUTYROLACTONE. GAMHA- 000096-48-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005872
CACODYLIC ACID 000075-60-5
NOEL 9.2 MG/KG/DAY RAT
ORAL: DIET 90 DAYS
NONE OBSERVED
3E-2
300
SUBCHRONIC [RfO] COMMENT: CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
3E-3
3000
005873
CADMIUM 007440-43-9
GENERAL COMMENT: A.LSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS
005280
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-18
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECJES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
[RfC]
Subchronic
[RfD]
Chronic
[RfC] [RfO]
REFERENCE
(ro/cu ro) (m/kg/day) (mg/cu n) (mq/kq/dav)
UF
UF
UF
UF
CALCIUH CYANIDE
NOAEL 19.1 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000592-01-8
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
4E-2
500
IRIS
010258
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfO] OT*IENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CAPROLACTAM
NOAEL 50 MG/KG/DAY
ORAL: DIET
000105-60-2
RAT
90 DAYS
KIDNEY
IRIS
EFFECTS
5E-1
100
IRIS
005284
005282
010966
CAPTAFOL
LOAEL 2 MG/KG/DAY
ORAL: CAPSULE
002425-06-1
DOG
12 MONTHS KIDNEY
BLADDER
EFFECTS
EFFECTS
2E-3
1000
IRIS
005874
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHS. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-19
-------
HEAST TABLE 1: SUBGHRQNIC AND CHRONIC TOXICITY (OTHER THAN CARCINOSEN1CITY) July 1997
Subchronie Chronic
CHEHICAL DOSE 5£££I£S [RfC] [RfO] [RfC] [RfO] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (ma/cu m) (mq/kg/dav) (mq/cu m) (inq/kq/day)
UF UF UF UF
CAPTAN 000133-06-2
NOEL 12.5 MG/KG/DAY RAT
ORAL: DIET WHOLE BODY DECREASED WEIGHT 1.3E-1 IRIS 005875
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfO].
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (05/27/92) BY THE RfO/RfC WORK GROUP.
CHRONIC [RfD] COMMENT: BASED ON A MULTI-GENERATION REPRODUCTION STUDY.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY,
CARBARYL 000063-25-2
NOAEL 9.6 MG/KG/DAY RAT
ORAL: DIET 2 YEARS KIDNEY TOXICITY 1E-1 IRIS 005876
LIVER TOXICITY 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS 010882
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (08/15/91) BY THE RfD/RfC WORK GROUP.
CARBOFURAN 001563-66-2
NOEL 0.5 MG/KG/DAY TO
ORAL: DIET 1 YEAR BLOOD CHOLINESTERASE INHIBITION 5E-3 IRIS 005877
TESTIS EFFECTS 100
UTERUS EFFECTS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD~WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) S69-7254. 1-20
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOSENICITY)
July 1997
CHEMICAL DOSE ffiCJUS
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
{fna/cu m) (ma/ko/dav) (mafeu m) (ma/ka/dav)
UF UF UF UF
CARBON OISULFIDE
NOEL 11 MG/KG/DAY
INHALATION:
INTERMITTENT
000075-15-0
RABBIT
FETUS
TOXICITY
1E-1
100
IRIS
010259
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS DETERMINED FROM A TERATOLOGY STUDY WITH EXPOSURES BEFORE AND DURING
THE ENTIRE GESTATION PERIOD.
BMC 19.7 MG/CU M
INHALATION:
INTERMITTENT
HUMAN OCCUPATIONAL
12,1 +/- PERIPHERAL DYSFUNCTION
6,9 YEARS SYSTEM
7E-1
30
IRIS
010975
CHROMIC RfC COMMENT: A BENCHMARK DOSE APPROACH WAS USED RATHER THAN A NOAEL/LOAEL TO DERIVE THE RfC,
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
CARBON MONOXIDE 000630-05-0
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
010493
CARBON TETRACHLORIDE
000056-23-5
CHLORAL
IRIS
010862
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN1CITY.
LOAEL 15.7 MG/KG/DAY
ORAL: DRINKING 90 DAYS
WATER
000075-87-6
MOUSE
LIVER
EFFECTS
2E-2
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
IRIS
005290
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATIOH: RISK INFORMATION HOTLINE- (513) 569-7254.
1-21
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOSENICITY)
July 1997
LEVEL
fiffit S£E£IP-
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronie Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
) (mq/kg/dav) (mo/cu ml (iro/ko/dav)
UF UF UF UF
CHLORDANE
NOEL 0.055 MG/KG/DAY
ORAL: DIET
000057-74-9
RAT
130 WEEKS LIVER
HYPERTROPHY
SU8CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORINE CYANIDE
NOAEL 25.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000506-77-4
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GHLQRO-1.3-BUTADIENE, 2- / (CHLOROPRENE) 000126-99-8
NOAEL 32 PPM RAT
INHALATION 90 DAYS OLFACTORY DEGENERATION
EPITHELIUM
7E-2
30
6E-5
1000
5E-2
500
IRIS
005296
IRIS
010261
7E-3
300
010515
SUBCHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLORO-M-CRESOL, P- 000059-50-7
NOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 28 DAYS WHOLE BODY
DECREASED WEIGHT GAIN
2E+Q
100
005366
CHLOROACETALDEHYDE 000107-20-0
GENERAL COMHENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005342
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-22
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL BQSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ITO/CU m) (mg/kq/dav) (mq/cu m) (mq/kq/dav)
UF UF UF UF
CHLOROACETIC ACID
LOAEL 30 MG/KG
ORAL: GAVAGE
000079-11-8
RAT
13 WEEKS
HEART
MYOCARDITIS
2E-2
1000
2E-3
10000
005346
CHLOROANILINE. 2- 000095-51-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005347
CHLOROANILINE. 3- 000108-42-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005348
CHLOROANILINE, 4-
LOAEL 12.5 MG/KG/DAY
ORAL: DIET
000106-47-8
RAT
78 WEEKS
SPLEEN
PROLIFERATE LESIONS
4E-3
3000
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHLOROBENZENE
000108-90-7
IRIS 005349
IRIS
010863
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST'TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER IHFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-23
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
CHEMICAL BQSE SPECIES
LEVEL EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
[RfC]
Subchronic
[RfD]
Chronic
[RfC] [RfD]
July 1997
REFERENCE
(mo/cu m) (mg/kq/dav) (mo/cu m) (mg/kq/dav)
UF
UF
UF
UF
CHLOROBENZILATE 000510-15-6
NOEL 5 M6/KG/DAY RABBIT
ORAL: GAVAGE 13 DAYS GASTRO- DECREASED STOOL QUANTITY 2E-2 IRIS
INTESTINAL SYSTEM 300
WHOLE BODY DECREASED FOOD CONSUMPTION
WHOLE BODY DECREASED WEIGHT GAIN
NERVOUS SYSTEM HYPERIRRITABILITY
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]. BASED ON A TERATOLOGY STUDY WITH
EXPOSURES DAYS 7-19 OF GESTATION.
CHRONIC [RfD] COMMENT: BASED ON A TERATOLOGY STUDY WITH EXPOSURES DURING DAYS 7-19 OF GESTATION.
CHRONIC [RfC] COMMENT; THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP.
010260
010931
CHLOROBENZOIC ACID. P-
NOAEL 26 MG/DAY
ORAL: DIET
000074-11-3
RAT
5 MONTHS
NONE OBSERVED
2E+0
100
2E-1 005360
1000
CHLOROBENZOTRIFLUORIDE,
NOAEL 15 MG/KG/DAY
ORAL: GAVAGE
RAT
000098-56-6
KIDNEY
TUBULAR DEGENERATION
2E-1
100
2E-2
1000
SUBCHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING,
DURING GESTATION, AND FOR 90 DAYS POST-WEANING.
CHRONIC [RfD] COMMENT- BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING, DURING
GESTATION. AND FOR 90 DAYS POST-WEANING.
005364
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-24
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD]
(im/cu m) (iDQ/kq/dav) (mo/cu m) (ma/kg/dav)
UF UF UF UF
July 1997
REFERENCE
CHLOROBUTANE, 1-
NOAEL 43 MG/KG/DAY
ORAL: GAVAGE
000109-69-3
RAT
103 WEEKS WHOLE BODY INCREASED MORTALITY
CENTRAL NERVOUS EFFECTS
SYSTEM
BLOOD HEMATOLOGIC EFFECTS
4E-1
100
005808
NOAEL 86 MG/KG/DAY RAT
ORAL; GAVAGE 13 WEEKS
WHOLE BODY DECREASED WEIGHT GAIN
CENTRAL EFFECTS
SYSTEM
SPLEEN HEMATOPOIESIS
9E-1
100
005806
CHLOROBUTANE, 2- 000078-86-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005809
CHLOROCYCLOPENTADIENE 041851-50-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005297
CHLOROFORM
LOAEL 12.9 MG/KG/OAY
ORAL: CAPSULE
000067-66-3
DOG
7.5 YEARS LIVER
LESIONS
1E-2
1000
IRIS 005372
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT. ALSO SEE HEAST TABLE 3. CARCINOGENICITY.
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFOPWTION: RISK INFORMATION HOTLINE: (513) 569-7254,
1-25
-------
HEAST TABLE 1; SUBCHRONIG AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) July 1997
Subchronic Chronic
CHEMICAL DQSE SPECIES [RfC] [RfD] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mq/cu m) (mo/kci/dav) (ma/cu m) (ma/kq/dav)
UF UF UF UF
CHLOROMETHANE / (METHYL CHLORIDE) 000074-87-3
010005
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLQRONITROBENZENE, M- 000121-73-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005879
CHLOROPHENOL. 2- 000095-57-8
NOAEL 50 PPM RAT
ORAL: DRINKING REPRODUCTION REPRODUCTIVE EFFECTS 5E-2 IRIS 010436
WATER 100
SUBCHRONIC [RfD] COMMENT: BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING, GESTATION AND WEANING.
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING, GESTATION AND WEANING.
CHLOROPHENOL, 3- 000108-43-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005309
CHLOROPHENOL, 4- 000106-48-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005310
CHLOROPROPANE, 2- 000075-29-6
NOAEL 91.4 MG/KG/DAY RAT
INHALATION: 4 WEEKS LIVER EFFECTS 1E+0 1E-1 010444
INTERMITTENT 100 1000
CHLOROTOLUENE, M- 000108-41-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005880
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: '513) 569-7254. 1-26
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ma/cu m) (mci/kci/dav) (ma/cu m) (ma/kg/dav)
UF UF UF UF
CHLOROTOLUENE. 0-
NOAEL 20 MG/KG/DAY
ORAL: GAVAGE
000095-49-8
RAT
103 DAYS
WHOLE BODY
DECREASED WEIGHT GAIN
2E-1
100
IRIS
010167
CHLOROTOLUENE, P- 000106-43-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
010200
CHLORPYRIFOS
NOEL 0.03 MG/KG/DAY
ORAL: CAPSULE
002921-88-2
HUMAN
20 DAYS OR BLOOD
9 DAYS
DECREASED CHOLINESTERASE
ACTIVITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
3E-3
10
IRIS 005881
CHLORPYRIFOS METHYL
NOAEL 1 MG/KG/DAY
ORAL: DIET
005598-13-0
RAT
REPRODUCTION DECREASED FERTILITY
GENERATIONS
RAT
2 YEARS
LIVER
EFFECTS
1E-2
100
1E-2 005882
100
CHLOROTHALONIL 001897-45-6
NOEL 1.5 MG/KG/DAY DOG
ORAL: DIET 2 YEARS KIDNEY
EFFECTS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1.5E-2
100
IRIS
005883
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-27
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mq/kq/dav) (mo/cu m) (mq/ka/dav)
UF UF UF UF
CHLORTHIOPHOS 060238-56-4
NOAEL 0.08 MG/KG/DAY RAT
ORAL: DIET 2 YEARS NONE OBSERVED
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
8E-4
100
8E-4 005884
100
CHROMIUM(III)
NOEL 5 % (CR203)
ORAL: DIET
016065-83-1
RAT
840 DAYS
NONE OBSERVED
1E+0
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: INHALATION ISSUES ARE UNDER REVIEW BY THE RFD/RFC WORK GROUP.
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
CHROMIUM(VI)
NOAEL 2.4 MG/KG/DAY
ORAL: DRINKING
WATER
018540-29-9
RAT
1 YEAR
NONE OBSERVED
2E-2
100
CHRONIC [RfC] COMMENT: INHALATION ISSUES ARE UNDER REVIEW BY THE RFD/RFC WORK GROUP.
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
IRIS
IRIS
005731
005522
CHRYSENE 000218-01-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
005885
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 5C9-7254.
1-28
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mq/kq/dav) (mg/cu m) (req/kg/dav)
UF UF UF UF
COPPER
LOAEL 5,3 MG
007440-50-8
HUMAN
SINGLE DOSE GASTRO-
IRRITATION
1,3 MG/L
1.3HG/L 005374
INTESTINAL SYSTEM
SUBCHRONIC [RfD] COMMENT: CURRENT DRINKING WATER STANDARD OF 1.3 MG/L. DWCD (1987) CONCLUDED TOXICITY DATA
INADEQUATE FOR CALCULATION OF AN RfD FOR COPPER.
CHRONIC [RfD] COMMENT: CURRENT DRINKING WATER STANDARD OF 1.3 MG/L. OWCD (1987) CONCLUDED TOXICITY DATA WERE
INADEQUATE FOR CALCULATION OF AN RfD FOR COPPER.
COPPER CYANIDE
NOAEL 5 MG/KG/DAY
ORAL: GAVA6E
000544-92-3
RAT
90 DAYS
LIVER
KIDNEY
WHOLE BODY
ORGANS
HISTQPATHQLOGY
HISTOPATHOLOGY
DECREASED WEIGHT
DECREASED WEIGHT
5E-2
100
IRIS
010262
CRESOL, H- / (3-METHYLPHENOL) 000108-39-4
NOAEL 50 MG/KG/DAY RAT
ORAL: GAVA6E 90 DAYS WHOLE BODY DECREASED WEIGHT GAIN
NERVOUS SYSTEM NEURQTOXICITY
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
5E-1
100
IRIS
IRIS
005380
010888
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfO/RfC WORK GROUP.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-29
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHEMICAL PISE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronlc Chronic
[RfC] [RfD] [RfC] [RfD]
(ma/cu m) (mo/kQ/dav) Ima/cu m) (mq/kq/dav)
UF UF UF UF
July 1997
REFERENCE
CRESOL. 0- / (2-METHYLPHENOL)
NOAEL 50 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000095-48-7
WHOLE BODY DECREASED WEIGHT GAIN
NERVOUS SYSTEM NEUROTOXICITY
5E-1
100
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS
005384
010889
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfO/RfC WORK GROUP,
CRESOL, P- / (4-METHYLPHENOL) 000106-44-5
NOAEL 5 MG/(KG-DAY) RABBIT
ORAL: GAVAGE GESTATION CENTRAL NERVOUS HYPOACTIVITY
DAYS 6-18 SYSTEM
RESPIRATORY DISTRESS
SYSTEM
WHOLE BODY MATERNAL DEATH
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL [RfO] WAS ADOPTED AS THE SUBCHRQNIC ORAL [RfO],
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY,
5E-3
1000
5E-3
1000
010516
IRIS
010890
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
CUMENE
NOAEL 154 MG/KG/DAY
ORAL: GAVAGE
NOAEL 105.1 PPM
INHALATION:
INTERMITTENT
000098-82-8
RAT
194 DAYS
RAT
4 WEEKS
KIDNEY
INCREASED WEIGHT
4E-1
300
IRIS
CENTRAL NERVOUS INVOLVEMENT
SYSTEM
NOSE IRRITATION
9E-2
1000
9E-3
10000
005392
005908
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-30
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfO] REFERENCE
) (mci/kq/dav) (iro/cp m) (m/kq/dav)
UF UF UF UF
CYANAZINE
NOEL 0.625 HG/KG/OAY DOS
ORAL: DIET 1 YEAR
021725-46-2
WHOLE BODY
BLOOD
BLOOD
DECREASED WEIGHT
INCREASED PLATELET COUNT
ALTERED CLINICAL CHEMISTRY
PARAMETERS
2E-3
300
2E-3
300
010411
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfO].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS WITHDRAWN FROM IRIS (07/01/92). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOSENICITY.
CYANIDE
NOAEL 10,8 MG/KG/OAY
ORAL: DIET
000057-12-5
RAT
104 WEEKS WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
2E-2
500
IRIS
005396
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfO].
GENERAL COMMENT: THE CASRN FOR CN- IS 000057-12-5; THE CASRN FOR HCN IS 000074-90-8.
CYANOGEN
NOAEL 21,6 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000460-19-5
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
4E-2
500
IRIS
010263
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL RfD
WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS. EPA'S INTEGRATED RISK. INFOWtTION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFCVWJGW HOTLINE: (513) 569-7254.
1-31
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (mq/cu m) (mq/kg/dav)
UF UF UF UF
CYANOGEN BROMIDE
NOAEL 44 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000506-68-3
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
9E-2
500
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
010264
CYCLOATE 001134-23-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005886
CYCLOHEXANOL 000108-93-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005887
CYCLOHEXYLAMINE
NOAEL 30 MG/KG/DAY
ORAL: DIET
000108-91-8
RAT
90 DAYS WHOLE BODY
TESTIS
DECREASED WEIGHT GAIN
DECREASED WEIGHT
3E-1
100
IRIS 005400
005398
CYCLOPENTADIENE
000542-92-7
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010494
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-32
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOSENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cuji) (ira/kg/dav) (iro/cu m) (mg/kg/dav)
UF UF UF UF
DACTHAL
NQAEL 1 M6/KG/DAY
ORAL: DIET
001861-32-1
RAT
2 YEARS
LUNG
LIVER
KIDNEY
THYROID
THYROID
HORMONES
EFFECTS
EFFECTS
EFFECTS
EFFECTS
EFFECTS
1E-2
100
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DALAPON 000075-99-0
NOEL 8.45 MG/KG/DAY RAT
ORAL DIET 2 YEARS KIDNEY
INCREASED RELATIVE WEIGHT
3E-2
300
IRIS
005888
IRIS
005889
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO DALAPON SODIUM BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DDT
000050-29-3
NOEL 0.05 MG/KG/DAY
ORAL. DIET
RAT
27 WEEKS
LIVER
LESIONS
5E-4
100
IRIS
005408
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT- ALSO SEE HEAST TABLE 3. CARCINOGENICITY.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254
1-33
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ITO/CU m) (md/kQ/dav) (mg/cu m) (ma/kg/dav)
UF
UF
UF
UF
DECABROMODIPHENYL ETHER 001163-19-5
NOEL 1 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER
INCREASED WEIGHT
1E-2
100
IRIS
005891
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DI-N-OCTYL PHTHALATE
LOAEL 175 MG/KG/DAY
ORAL: DIET
000117-84-0
RAT
7-12 MONTHS KIDNEY
LIVER
LIVER
LIVER
INCREASED WEIGHT
INCREASED WEIGHT
INCREASED SCOT ACTIVITY
INCREASED SGPT ACTIVITY
2E-2
1000
2E-2
1000
010275
DIAZINON
NOAEL 0.09 MG/KG/DAY
ORAL. DIET
000333-41-5
RAT
35-42 DAYS BLOOD
DECREASED CHOLINESTERASE
ACTIVITY
9E-4
100
9E-4
100
005892
DIBENZOFURAN 000132-64-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005409
DIBROMOBENZENE. 1.4-
NOAEL 10 MG/KG/OAY
ORAL- GAVAGE
000106-37-6
RAT
45 OR 90
DAYS
LIVER
LIVER
INCREASED RELATIVE WEIGHT
ALTERED ENZYME ACTIVITIES
1E-1
100
IRIS
005893
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254.
1-34
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (tnq/kQ/dav) (mg/cu m) (mg/ka/dav)
UF UF UF UF
DIBROMOCHLOROMETHANE 000124-48-1
NOEL 21 4 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS LIVER LESIONS
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
2E-1
100
IRIS 005894
DIBROMOETHANE, 1,2-
LOAEL 88 PPB
INHALATION:
INTERMITTENT
HUMAN
000106-93-4
SPERM
EFFECTS
2E-3
100
2E-4
1000
SUBCHRONIC [RfC] COMMENT THE CHRONIC INHALATION [RfC] WAS MODIFIED TO ESTIMATE THE SUBCHRONIC INHALATION [RfC]
CHRONIC [RfC] COMMENT. UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
DIBUTYL PHTHALATE 000084-74-2
NOAEL 125 MG/KG/DAY RAT
ORAL DIET 52 WEEKS WHOLE BODY
INCREASED MORTALITY
1E+0
100
IRIS
IRIS
CHRONIC RfC COMMENT- THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (07/26/90) BY THE RfD/RfC WORK GROUP
DICAMBA
NOAEL 3 MG/KG/DAY
ORAL GAVAGE
001918-00-9
RABBIT
GESTATION FETUS
DAYS 6-18 FETUS
FETUS
DAM
DECREASED WEIGHT
INCREASED POST-IMPLANTATION
LOSSES
INCREASED MORTALITY
DECREASED WEIGHT GAIN
3E-2
100
IRIS
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
010854
005622
010892
010945
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-35
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mo/cu m) (mq/kg/dav) Jjna/cu m) (mg/kq/dav)
UF UF UF UF
DICHLOROBENZENE, 1.2- 000095-50-1
IRIS 010864
GENERAL COMMENT- ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
DICHLOROBENZENE, 1.3- 000541-73-1
CHRONIC [RfD] COMMENT. THE CHRONIC ORAL [RfD] IS NOT VERIFIABLE (06/23/92) BY THE RfD/RfC WORK
005414
DICHLOROBENZENE, 1,4-
NOAEL 75 MG/CU M
INHALATION.
INTERMITTENT
000106-46-7
RAT
MULTI-GENERA LIVER
TION
INCREASED WEIGHT IN MALE 2 5E+0
PARENTS 30
IRIS
SUBCHRONIC [RfC] COMMENT. THE CHRONIC INHALATION RfC WAS MODIFIED TO ESTIMATE THE SUBCHRONIC INHALATION [RfC].
GENERAL COMMENT; ALSO SEE HEAST TABLE 3: CARCINOGEN!CITY.
010840
DICHLOROBUTENES
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005415
DICHLORODIFLUOROMETHANE
NOAEL 90 MG/KG/DAY
ORAL: DIET
000075-71-8
IRIS
DOG
90 DAYS
NONE OBSERVED
9E-1
100
005498
005496
SUBCHRONIC [RfC] COMMENT- ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT- ALSO SEE HEAST TABLE 2. ALTERNATE -- AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE, (513) 569-7254
1 36
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
DOSE
ROUTE
EXPERIHENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfO]
(mq/cu m) dnq/kQ/dav)
UF UF
Chrome
[RfC] [RfD] REFERENCE
IIHQ/CU ml (ma/kq/day)
UF UF
DICHLOROETHANE, 1,1-
NOEL 115 MG/KG/DAY
INHALATION
INTERMITTENT
000075-34-3
RAT
13 WEEKS
NONE OBSERVED
1E+0
100
1E-1
1000
005790
SU8CHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENI CITY)
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION
GENERAL COMMENT ALSO SEE HEAST TABLE 3; CARCINOGENICITY.
DICHLOROETHYLENE, 1,1-
LOAEL 9 MG/KG/DAY
ORAL: DRINKING
WATER
000075-35-4
RAT
2 YEARS
LIVER
LESIONS
9E-3
1000
IRIS
005419
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT" ALSO SEE HEAST TABLE 3 CARCINOGENICITY
DICHLOROETHYLENE, 1,2- (MIXED ISOMERS) 000540-59-0
LQAEL 50 PPM RAT
ORAL- DRINKING 2 YEARS LIVER LESIONS
WATER
9E-3
1000
9E-3
1000
010509
SUBCHRONIC [RfD] COMMENT. VALUES DERIVED FOR 1.1-DICHLOROETHYLENE WERE ADOPTED FOR 1.2- DICHLOROETHYLENE MIXED ISOMERS
BASED ON ANALOGY.
CHRONIC [RfD] COMMENT VALUES DERIVED FOR 1.1-DICHLOROETHYLENE (000075-35-4) WERE ADOPTED FOR 1,2-DICHLOROETHYLENE MIXED
ISOMERS BASED ON ANALOGY.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254.
1-37
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chrome
[RfC] [RfD] [RfC] [RfDJ REFERENCE
(mg/cy. m) (ro/kQ/ddv) (ITO/CU m) (mq/kg/dav)
UF UF UF UF
DICHLOROETHYLENE, 1,2-C- 000156-59-2
NOAEL 32 MG/KG/DAY RAT
ORAL- GAVAGE 90 DAYS BLOOD
BLOOD
DECREASED HEMATOCRIT
DECREASED HEMOGLOBIN
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUHBER SUBJECT TO CHANGE,
1E-1
300
1E-2
3000
005420
DICHLOROETHYLENE. 1,2-T-
NOAEL 17 MG/KG/DAY
ORAL: DRINKING
WATER
000156-60-5
MOUSE
90 DAYS
BLOOD
INCREASED ALKALINE PHOSPHATASE
2E-1
100
IRIS
005B95
DICHLOROPHENOL, 2,3- 000576-24-9
GENERAL COMHENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005315
DICHLOROPHENOL, 2,4-
NOEL 3 PPM RAT
ORAL: DRINKING 2
WATER GENERATIONS
000120-83-2
IMMUNE SYSTEM ALTERED IMMUNE FUNCTION
3E-3
100
SUBCHRONIC [RfO] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE ORAL [RfD].
CHRONIC [RfD] COMMENT- BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES BEFORE AND DURING GESTATION,
PARTURITION. AND WEANING OF PUPS.
IRIS
005314
DICHLOROPHENOL, 2,5- 000583-78-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005316
DICHLOROPHENOL, 2,6- 000087-65-0
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005317
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INrQRMATION HOTLINE: (513) 569-7254
1-38
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
DICHLOROPHENOL, 3.4- 000095-77-2
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (ma/ka/dav) (mq/cu m) (mq/ka/dav)
UF UF UF UF
005318
DICHLOROPHENOL. 3.5- 000591-35-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005319
DICHLOROPHENOXY ACETIC ACID. 2.4- 000094-75-7
NOAEL 1 MG/KG/DAY RAT
ORAL: DIET 91 DAYS BLOOD TOXICITY
LIVER TOXICITY
KIDNEY TOXICITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
1E-2
100
IRIS
010265
DICHLOROPHENOXY) BUTYRIC ACID, 4-(2,4- / (2,4-DB) 000094-82-6
NOAEL 8 MG/KG/DAY DOG
ORAL- DIET 90 DAYS CARDIOVASCULAR HEMORRHAGE
SYSTEM
WHOLE BODY INCREASED MORTALITY
8E-2
100
IRIS
005890
DICHLOROPROPANE, 1,1- 000078-99-9
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
DICHLOROPROPANE. 1.2-
NOAEL 69.3 MG/CU
INHALATION.
INTERMITTENT
000078-87-5
RAT
13 WEEKS
NASAL MUCOSA HYPERPLASIA
GENERAL COMMENT ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1 3E-2
100
IRIS
005897
005898
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-39
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(rnq/cu m) (mo/ko/dav)
UF UF
Chrome
[RfC] [RfD] REFERENCE
(niq/cu_jn) (ma/kq/dav)
UF UF
DICHLOROPROPANE, 1.3-
GENERAL COMMENT-
000142-28-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005899
DICHLOROPROPANE, 2,2- 000594-20-7
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005900
DICHLOROPROPENE, 1,3- / (TELONE II)
NOEL 3 MG/KG/DAY RAT
ORAL. DIET 90 DAYS ORGANS
000542-75-6
INCREASED WEIGHT
GENERAL COMMENT- ALSO SEE HEAST TABLE 3 CARCINOGENICITY.
NOAEL 5 PPM MOUSE
INHALATION: 2 YEARS
INTERMITTENT
NASAL MUCOSA HYPERTROPHY
NASAL MUCOSA HYPERPLASiA
3E-3
1000
IRIS
005901
2E-2
30
IRIS
010351
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
DICHLORPROP 000120 -36-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
005896
DICYCLOPENTADIENE
NOEL 32 MG/KG/DAY
ORAL: DIET
000077-73-6
RAT
NONE OBSERVED
GENERATIONS
3E-1
100
3E-2
1000
005425
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2' ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRQNIC [RfD] COMMENT: ON A 3-GENERATION REPRODUCTION STUDY.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT- BASED ON A 3-GENERATION REPRODUCTION STUDY.
IRIS. ERA'S INTEGRATED RISK INFORMATION CYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-40
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY) July 1997
Subchromc Chrome
CHEMICAL DOSE SPECIES [RfC] [RfO] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mq/cu m) (mq/kg/dayl (mo/cu m) (mq/kq/day)
UF UF UF UF
DIELDRIN 000060-57-1
NOAEL 0.005 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER LESIONS 5E-5 IRIS 005429
100
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL RfO WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT- ALSO SEE HEAST TABLE 3. CARCINOGENICITY.
DIETHYL PHTHALATE 000084-66-2
NOAEL 750 MG/KG/OAY RAT
ORAL- DIET 16 BODY GROWTH 8E+0 IRIS
ORGANS DECREASED WEIGHT 100
DIETHYL-P-NITROPHENYL PHOSPHATE 000311-45-5
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005922
DIETHYLANILINE. N.N- 000091-66-7
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005903
DIETHYLENE GLYCOL MONOBUTYL ETHER 000112-34-5
NOAEL 18 PPM RAT
NONE OBSERVED 2E-1 2E-2 005482
100 1000
CHRONIC [RfC] COMMENT- UNDER REVIEW
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY FURTHER I FORMAT I ON- RISK INFORMATION HOTLINE' (513) 569-7254. 1-41
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mq/kq/dav) (mg/cu m) (mq/kq/day)
UF UF UF UF
DIETHYLENE GLYCOL MONOETHYL ETHER 000111-90-0
NOEL 200 MG/KG/DAY RAT
ORAL. DRINKING KIDNEY
WATER
HISTOPATHOLOGY
CHRONIC [RfD] COMMENT. BASED ON A 3-GENERATION REPRODUCTION STUDY.
NOEL 500 MG/KG/DAY RAT
ORAL- DIET 90 DAYS
KIDNEY
TESTIS
IMPAIRED FUNCTION
INCREASED WEIGHT
5E+0
100
2E+0
100
005478
005476
DIETHYLFORMAMIDE 000617-84-5
NOEL 0.546 MG/DAY. 5 DAYS/WEEK RAT
ORAL GAVAGE 73 WEEKS
NONE OBSERVED
1.1E-2
100
1 1E-2 010437
100
DIETHYLHYDRAZINE, 1,2- 001615-80-1
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3. CARCINOGENICITY
005921
DIMETHOATE 000060-51-5
NOEL 0.05 MG/KG/DAY RAT
ORAL. DIET 2 YEARS BRAIN
DECREASED CHOLINESTERASE
ACTIVITY
2E-4
300
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS 005923
DIMETHYLANILINE. N.N-
LOAEL 22.32 MG/KG/DAY
ORAL- GAVAGE
000121-69-7
MOUSE
13 WEEKS
SPLEEN
EFFECTS
2E-2
1000
IRIS 005924
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254
1-42
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kQ/dav) (mo/cu m) (mg/kq/dav)
UF UF UF UF
DIMETHYLFORMAMIOE, N,N-
NOAEL 96 MG/KG/DAY RAT
ORAL- DIET 119 DAYS
LOAEL 22 MG/CU M
INHALATION:
INTERMITTENT
HUMAN
000068-12-2
LIVER
LIVER
GASTRO
EFFECTS
EFFECTS
EFFECTS
1E+0
100
3E-2
300
INTESTINAL SYSTEM
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RFC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RFC].
IRIS
1E-1
1000
005925
010352
DINETHYLPHENOL, 2,3- 000526-75-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005926
DIMETHYLPHENOL. 2,4- 000105-67-9
NOAEL 50 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS
NERVOUS SYSTEM EFFECTS
BLOOD ALTERATIONS
2E-1
300
IRIS
010266
DIMETHYLPHENOL, 2,5- 000095-87-4
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005928
DIMETHYLPHENOL, 2.6-
NOEL 0 6 MG/KG/DAY
ORAL
000576-26-1
RAT
8 MONTHS WHOLE BODY
ORGANS, MAJOR
INCREASED WEIGHT
LESIONS
6E-3
100
IRIS
005431
IRIS, EPA'S INTEGPATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-43
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL EXPERIMENT
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(ITO/CU m) (mg/kq/dav) (mo/cu m) (mg/ka/dav)
UF UF UF UF
DIMETHYLPHENOL, 3.4-
NOEL 1,4 MG/KG/DAY
ORAL
000095-65-8
RAT
8 MONTHS WHOLE BODY DECREASED WEIGHT
ORGANS. MAJOR LESIONS
CARDIOVASCULAR ALTERED BLOOD PRESSURE
SYSTEM
1E-2
100
IRIS
005437
DIMETHYLPHTHALATE 000131-11-3
CHRONIC RfD COMMENT THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (02/16/94) BY THE RfD/RfC WORK
IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (07/26/90) BY THE RfD/RfC WORK GROUP.
010267
010894
DIMETHYLTEREPHTHALATE
LOAEL 125 MG/KG/DAY
ORAL. DIET
000120-61-6
RAT
103 WEEKS KIDNEY
INFLAMMATION
1E-1-
1000
IRIS
005930
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfO]
DIMETHYLUREA. N,N- 000598-94-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005931
DINITRO-0-CRESOL, 4.6- 000534-52-1
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP. 010470
DINITRO-P-CRESOL, 2,6- 000609-93-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005934
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254
1-44
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/gy mj (inq/kg/day) (ro/cu m) (ma/kg/day)
UF UF UF UF
DINITROBENZENE, 1.2- 000528-29-0
NOAEL 0,4 HG/K6/DAY RAT
ORAL: DRINKING 16 WEEKS SPLEEN
WATER
INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
CHRONIC [RfD] COMMENT DERIVED BY ANALOGY TO 1,3-DINITROBENZENE
4E-3
100
4E-4
1000
010201
DINITROBENZENE, 1,3-
NOAEL 0.4 MG/KG/OAY
ORAL: DRINKING
WATER
RAT
000099-65-0
SPLEEN
INCREASED WEIGHT
1E-3
100
IRIS
010471
DINITROBENZENE, 1,4-
NQAEL 0.4 MG/KG/DAY
ORAL: DRINKING
WATER
000100-25-4
RAT
16 WEEKS
SPLEEN
INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT DERIVED BY ANALOGY TO 1,3-DINITROBENZENE
CHRONIC [RfD] COMMENT- DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
4E-3
100
4E-4
1000
010202
DINITROPHENOL, 2,3- 000066-56-8
' GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005936
DINITROPHENOL, 2,4-
LOAEL 2 MG/KG/DAY
ORAL
HUMAN
000051-28-5
EYE
CATARACT
2E-3
1000
[RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE ORAL [RfD]
IRIS
IRIS
CHRONIC RfC COMMENT THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (06/13/91) BY THE RfD/RfC WORK GROUP
010438
010895
IRIS, EPA'S INTEGRATED RlSf INFORMATION SYSTEM, IS UPDATED MONTHLY, FURTHER INFORMATION. R!SK INFORMATION HOTLINE: (513) 569-7254
1-45
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DQ5E SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(TO/CU m) (ing/kq/dav) (mq/cu m) (mq/kq/day)
UF UF UF UF
DINITROPHENOL, 2,5- 000329-71-5
GENERAL COHMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROPHENOL, 2,6-
GENERAL COMMENT
000573-56-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005937
005938
DINITROPHENOL, 3,5- 000586-11-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005939
DINITROTOLUENE, 2,3- 000602-01-7
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROTOLUENE, 2,4- 000121-14-2
NOAEL 0,2 MG/KG/DAY DOG
ORAL GELATIN UP TO 2
CAPSULE YEARS
CENTRAL NERVOUS NEUROTOXICITY
SYSTEM
ERYTHROCYTES HEINZ BODIES
BILIARY TRACT HYPERPLAS1A
2E-3
100
IRIS
005940
005941
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD IS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT. ALSO SEE HEAST TABLE 3. CARCINOGENICITY
IRIS
010896
CHRONIC RfC COMMENT THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/20/90) BY THE RfD/RfC WORK GROUP
DINITROTOLUENE, 2.5-
GENERAL
000619-15-8
DATA FOR QUANTITATIVE RISK ASSESSMENT
005942
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-46
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
July 1997
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfD]
(ma/cu m) (mq/ko/day)
UF UF
Chronic
[RfC] [RfD]
(mo/cu m) (ma/ka/dav)
UF UF
REFERENCE
DINITROTOLUENE. 2,6-
NOAEL 4 MG/KG/DAY
ORAL: DIET
000606-20-2
DOG
13 WEEKS
WHOLE BODY
CENTRAL NERVOUS
SYSTEM
BLOOD
BLOOD
BILE DUCT
KIDNEY
MORTALITY
NEUROTOXICITY
HEINZ BODIES
METHEMOGLOBINEMIA
HYPERPLASIA
HISTOPATHOLOGY
CHRONIC [RfD] COMMENT: UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE
GENERAL COMMENT ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1E-2
300
1E-3
3000
005943
DINITROTOLUENE. 3,4- 000610-39-9
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005944
DINOSEB 000088-85-7
LOAEL 1 MG/KG/DAY RAT
ORAL: DIET 29 WEEKS FETUS
DECREASED WEIGHT
1E-3
1000
IRIS 005945
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RFD WAS ADOPTED AS THE SUBCHRONIC ORAL [RFD].
CHRONIC [RfD] COMMENT. THE CHRONIC ORAL RFD WAS DETERMINED FROM A 3-GENERATION REPRODUCTION STUDY.
DIPHENYLAMINE, N,N-
NOEL 2.5 MG/KG/DAY DOG
ORAL- DIET 2 YEARS
000122-39-4
WHOLE BODY
LIVER
KIDNEY
DECREASED WEIGHT GAIN
INCREASED WEIGHT
INCREASED WEIGHT
2 5E-2
100
IRIS 005946
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE (513) 569-7254.
1-47
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEHICAL DOSE SPECIES
LEVEL ROUTE EXPERIHENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (ma/kq/davj (mq/cu m) (mo/kq/dav)
UF UF UF UF
DIRECT LIGHTFAST BLUE 004399-55-7
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005947
DISULFOTON
LOAEL 0.04 MG/KG/DAY
ORAL DIET
000298-04-4
RAT
2 YEARS EYE
BLOOD
DEGENERATION
CHQLINESTERASE INHIBITION
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
ENDOSULFAN
NOAEL 15 PPM
ORAL: DIET
NOAEL 10 PPM
ORAL: DIET
000115-29-7
RAT
2 YEARS WHOLE BODY
KIDNEY
BLOOD VESSEL
DOG
1 YEAR
WHOLE BODY
DECREASED WEIGHT GAIN
GLQMERULONEPHRQSIS
ANEURYSMS
DECREASED WEIGHT GAIN
4E-5
1000
6E-3
100
IRIS
IRIS
010412
010926
010938
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHORNIC ORAL [RfD] BASED ON CQ-CRITICAL RAT AND DOG
STUDIES.
ENDOTHALL
NOEL 2 MG/KG/DAY
ORAL DIET
000145-73-3
DOG
2 YEARS STOMACH INCREASED WEIGHT
SMALL INTESTINE INCREASED WEIGHT
2E-2
100
IRIS
005948
SUBCHRONIC [RfO] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
'PIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLV. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254
1-48
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mg/kg/dav) (mq/cu m) (mg/kg/dav)
UF
UF
UF
UF
ENDRIN 000072-20-8
NOEL 0 025 MG/KG/DAY DOG
ORAL: DIET 2 YEARS
CENTRAL NERVOUS CONVULSIONS
SYSTEM
LIVER LESIONS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
3E-4
100
EPICHLOROHYDRIN
LOAEL 37.8 MG/CU M
INHALATION:
INTERMITTENT
000106-89-8
RAT
136 WEEKS KIDNEY
LESIONS
2E-3
1000
IRIS
005445
2E-3
1000
010440
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE-TO-ROUTE EXTRAPOLATION. THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (04/01/92)
GENERAL COMMENT: ALSO SEE HEAST TABLE 3' CARCINOGENICITY
NOAEL 19 MG/CU M RAT
INHALATION. 90 DAYS NASAL
INTERMITTENT EPITHELIUM
LESIONS
1E-2
100
IRIS
010492
EPTC
NOEL 2.5 MG/KG/DAY
ORAL DIET
000759-94-4
RAT
2 HEART
GENERATIONS
DEGENERATIVE CARDIOMYOPATHY
2 5E-2
100
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RFD WAS DETERMINED FROM A 2-GENERATION REPRODUCTION STUDY.
IRIS
005959
ETHOPROP 013194-48-4
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005951
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254.
1-49
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) dnu/kq/dav) (mq/cu m) (mq/kq/dav)
UF UF UF UF
ETHOXYETHANOL ACETATE, 2- 000111-15-9
010507
SUBCHRONIC [RfD] COMMENT. ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT- ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ETHOXYETHANOL ACRYLATE, 2- 000106-74-1
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ETHOXYETHANOL DODECANOATE, 2- 000106-13-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005953
005956
ETHOXYETHANOL PHOSPHATE. 2- 068554-00-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005955
ETHOXYETHANOL, 2-
LOAEL 357 MG/KG/DAY
ORAL: GAVAGE
000110-80-5
RAT
103 WEEKS
WHOLE BODY
DECREASED WEIGHT
NOEL 50 uL/KG/DAY RAT
ORAL- GAVAGE 21 DAYS
FETUS
5E-1
100
SKELETAL MALFORMATIONS
SUBCHRONIC [RfD] COMMENT BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 1-21 OF GESTATION
4E-1
1000
005470
005468
NOAEL 380 MG/CU M RABBIT
INHALATION- 13 WEEKS
INTERMITTENT
BLOOD
ALTERED HEMATOLOGY
2E+0
30
IRIS
010441
ETHOXYETHYL METHACRYLATE, 2- 002370-63-0
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005954
IRIS. EFA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-50
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subclvonic
[RfC] [RfD]
(mg/cu m) (mq/ka/dav)
UF UF
Chrome
[RfC] [RfD]
(mq/cu m) (mq/kq/dav)
UF UF
REFERENCE
ETHYL ACETATE
NOEL 900 MG/KG/DAY RAT
ORAL. GAVAGE 90 DAYS
000141-78-6
WHOLE BODY
WHOLE BODY
INCREASED MORTALITY
DECREASED WEIGHT
9E+0
100
IRIS
005957
ETHYL BENZENE
000100-41-4
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER- (513) 569-7300
SUBCHRONIC [RfD] COMMENT- CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300.
ETHYL CHLORIDE
NOAEL 1504 PPM
INHALATION
INTERMITTENT
000075-00-3
MOUSE
10 DAYS
FETUS
DEVELOPMENTAL TOXICITY
1E+1
300
SUBCHRONIC [RfC] COMMENT. THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC]
CHRONIC [RfC] COMMENT BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
IRIS
IRIS
IRIS
010867
010866
010371
ETHYL ETHER 000060-29-7
NOAEL 500 MG/KG/DAY RAT
ORAL GAVAGE 90 DAYS LIVER
EFFECTS
2E+0
300
IRIS
010396
IRIS. ERA'S INTEGRATED RISK INFORMATION 5KSTW. IS UPDATED MONTHLY FURTHER INFORMATION- RISK INFORMATION HOTLINE. (513) 569-7254
1-51
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
ETHYL METHACRYLATE
NOEL 7 5 MG/KG/DAY RAT
ORAL- DRINKING 2 YEARS
WATER
TARGET
000097-63-2
KIDNEY
CRITICAL EFFECT
INCREASED RELATIVE WEIGHT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ma/cu ..m) (iro/kq/dav) (iro/cu m) (mq/kg/dav)
UF UF UF UF
9E-2
100
9E-2
100
005961
CHRONIC [RfO] COHMENT. CALCULATED FROM METHYL METHACRYLATE DATA BY MULTIPLYING BY THE RATIO OF THE MOLECULAR WEIGHTS (114 5/100.13).
ETHYL-0-XYLENE, 4- 000934-80-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
010472
ETHYLANILINE, N- 000103-69-5
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005958
ETHYLENE CYANOHYDRIN
NOEL 30 MG/KG/DAY
ORAL DRINKING
WATER
RAT
90 DAYS
000109-78-4
HEART
BRAIN
DECREASED WEIGHT
DECREASED WEIGHT
3E-1
100
3E-1
100
005780
ETHYLENE DIAHINE 000107-15-3
NOAEL 22 6 MG/KG/DAY RAT
ORAL DIET 3 MONTHS HEART
BLOOD
DECREASED WEIGHT
HEMOTOIQGIC CHAHGES
2E-1
100
2E-2
1000
IRIS
CHRONIC RfC COMMENT THE INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/18/90) BY THE RfO/RfC WORK GROUP.
005796
010898
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
1-52
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/ka/dav) (mq/cu m) (ma/kQ/dav)
UF UF UF UF
ETHYLENE GLYCOL
NOEL 200 MG/KG/DAY
ORAL: DIET
RAT
000107-21-1
FETUS
FETOTOXICITY
2E+0
100
SUBCHRONIC [RfD] COMMENT BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
ETHYLENE GLYCOL MONOBUTYL ETHER 000111-76-2
NOAEL 121 MG/CU M RAT
INHALATION: 13 WEEKS BLOOD
INTERMITTENT
ALTERED HEMATOLOGY
CHRONIC [RfC] COMMENT UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
2E-1
100
2E-2
1000
IRIS 005454
005452
010353
ETHYLENE THIOUREA
LOAEL 0.25 MG/KG/DAY
ORAL: DIET
000096-45-7
RAT
24 MONTHS THYROID
HYPERPLASIA
8E-5
3000
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
CHRONIC [RfC] COMMENT. THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/12/92) BY THE RfD/RfC WORK GROUP
010397
010899
ETHYLTOLUENE. M- 000620-14-4
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005963
ETHYLTOLUENE, 0- 000611-14-3
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005962
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254
1-53
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mo/.cu m) (mq/kq/dav) (im/cu m) (mq/ka/day)
UF UF UF UF
ETHYLTOLUENE. P- 000622-96-8
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005964
FLUORANTHENE
NQAEl 125 MG/KG/DAY HOUSE
ORAL- GAVAGE 90 DAYS
000206-44-0
KIDNEY
LIVER
BLOOD
NEPHROPATHY
WEIGHT CHANGES
HEMATOLOGICAL CHANGES
4E-1
300
IRIS
CHRONIC [RfC] COMMENT THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP.
010168
010967
FLUORENE 000086-73-7
NOAEL 125 MG/KG/DAY MOUSE
ORAL GAVAGE 13 WEEKS
ERYTHROCYTES DECREASED COUNTS
FLUORINE / (SOLUBLE FLUORIDE) 007782-41-4
NOAEL 0 06 MG/KG/DAY HUMAN
ORAL: DRINKING TOOTH
WATER
FLUOROSIS
4E-1
300
6E-2
1
IRIS
IRIS
010169
005965
FLURIDONE
NOEL 200 PPM RAT
ORAL: DIET 2 YEARS
059756-60-4
KIDNEY
TESTIS
WHOLE BODY
ORGANS
GLOMERULONEPHRITIS
ATROPHY
DECREASED WEIGHT
DECREASED WEIGHT
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfO].
8E-2
100
IRIS
005966
IRIS. EPA'5 INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-54
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mu/cu m) (mq/ka/dav) (mg/cu m) (mq/ka/dav)
UF UF UF UF
FOLPET
NOEL 10 MG/KG/DAY DOG
ORAL: CAPSULE 1 YEAR
000133-07-3
WHOLE BODY
BLOOD
ALTERED WEIGHT GAIN
ALTERED CHEMISTRY
1E-1
100
IRIS
005967
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
FORMALDEHYDE
NOAEL 15 MG/KG/DAY RAT
ORAL: WATER 2 YEARS
000050-00-0
GASTRO- LESIONS
INTESTINAL TRACT
2E-1
100
IRIS
010398
GENERAL COMMENT ALSO SEE HEAST TABLE 3- CARCINOGENICITY.
FORMALDEHYDE CYANOHYDRIN 000107-16-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005782
FORMIC ACID
NOAEL 200 MG/KG/DAY
ORAL WATER
000064-18-6
RAT
MULTI-
GENERATION
WHOLE BODY
DECREASED GROWTH
2E+0
100
CHRONIC [RfD] COMMENT BASED ON A MULTI-GENERATION STUDY. WITHDRAWN FROM IRIS (12/01/90) UNDER REVIEW.
CURRENT NUMBER SUBJECT TO CHANGE
2E+0
100
010268
FURAN 000110-00-9
NOAEL 1.4 MG/KG/DAY MOUSE
ORAL GAVAGE 13 WEEKS LIVER
LESIONS
1E-2
100
IRIS
005462
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATE MONTHLY FURTHER INFORMATION' RISK INFORMATION HOTLINE: (513) 569-7254.
1-55
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY {OTHER THAN CARCINQGENICITY)
July 1997
DOSE
ROUTE
EXPERIHENT LENGTH
TARGET
CRITICAL EFFECT
Subchronlc Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(m/cu m) (mg/kq/dav) (mq/cu m) (mq/kq/dayj
UF UF UF UF
FURFURAL
LOAEL 7 9 MG/KG/DAY
ORAL: GAVAGE
000098-01-1
RAT
13 WEEKS
LIVER
HEPATOTOXICITY
3E-2
300
IRIS
005466
SUBCHRONIC [RfC] COMMENT. ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT- ALSO SEE HEAST TABLE 2. ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SLYCIDALDEHYDE
NOAEL 29 MG/CU M
INHALATION.
INTERMITTENT
000765-34-4
RAT
12 WEEKS
WHOLE BODY
KIDNEY
DECREASED WEIGHT
EFFECTS
1E-2
300
4E-3
300
1E-3
3000
IRIS
005968
SUBCHRONIC [RfD] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5.
CHRONIC [RfD] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5.
GENERAL COMMENT ALSO SEE HEAST TABLE 3- CARCINOGENICITY.
HEPTACHLOR 000076-44-8
NOEL 0.15 MG/KG/DAY RAT
ORAL, DIET 2 YEARS LIVER
INCREASED WEIGHT
5E-4
300
IRIS
005506
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT. ALSO SEE HEAST TABLE 3 CARCINOGENICITY
HEPTACHLOR EPOXIDE 001024-57-3
LOAEL 0.0125 MG/KG/DAY DOG
ORAL DIET 60 WEEKS LIVER
INCREASED RELATIVE WEIGHT
1 3E-5
1000
IRIS
010399
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfO WAS ADOPTED AS THE ORAL [RfD].
GENERAL COMMENT ALSO SEE HEAST TABLE 3 CARCINOGENICITY
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE. (513) 569-7254.
1-56
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ma/cu m) (mq/ka/day) (iro/cu (nj (mg/kq/dav)
UF UF UF UF
HEPTANE, N- 000142-82-5
GENERAL COMMENT, DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005969
HEXABROMOBENZENE
NOAEL 2 MG/KG/DAY
ORAL: DIET
000087-82-1
RAT
12 WEEKS LIVER
INDUCED CARBOXYLESTERASE
ACTIVITY
2E-2
100
IRIS
005970
HEXACHLOROBENZENE
000118-74-1
IRIS
IRIS
CHRONIC RfC COMMENT THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/15/90) BY THE RfO/RfC WORK GROUP
SUBCHRONIC [RfC] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
GENERAL COMMENT ALSO SEE HEAST TABLE 3. CARCINOGENICITY.
HEXACHLOROBUTADIENE
LOAEL 0.5 MG/KG/DAY MOUSE
ORAL DIET 13 WEEKS
000087-68-3
RENAL TUBULES REGENERATION
CHRONIC [RfD] COMMENT WITHDRAWN FROM IRIS (05/01/93) UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC [RfD] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300.
2E-4
1000
010868
010900
010927
HEXACHLOROCYCLOHEXANE. DELTA- 000319-86-8
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT ALSO SEE HEAST TABLE 3. CARCINOSENICITY
010495
HEXACHLOROCYCLOHEXANE, EPSILON- 006108-10-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3 CARCINOGENICITY.
010496
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254.
1-57
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
HEXACHLOROCYCLOHEXANE. GAMMA- 000058-89-9
NOAEL 0.33 MG/KG/DAY RAT
ORAL: DIET 12 WEEKS LIVER
KIDNEY
CRITICAL EFFECT
TOXICITY
TOXICITY
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mq/cu m) (mq/kq/dav) (mq/gy m) (mq/kq/day)
UF UF UF UF
3E~3
100
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 3 CARCINOGENICITY.
CHRONIC [RfC] COMMENT* THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (05/27/92) BY THE RfD/RfC WORK GROUP.
005537
010903
HEXACHLOROCYCLOPENTADIENE 000077-47-4
NOAEL 7.1 MG/KG/DAY RAT
ORAL 13 WEEKS
FORESTOMACH
NOAEL 0.15 PPM RAT
INHALATION: 13 WEEKS
INTERMITTENT
LESIONS
NASAL CAVITY SQUAMOUS METAPLASIA
7E-2
100
7E-4
100
7E-5
1000
IRIS
005299
010445
HEXACHLOROETHANE
NOAEL 1 MG/KG/DAY
ORAL: DIET
000067-72-1
RAT
16 WEEKS
KIDNEY
DEGENERATION
1E-2
100
IRIS
GENERAL COMMENT' ALSO SEE HEAST TABLE 3 CARCINQGENICITY.
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (11/05/92), BY THE RfD/RfC WORK GROUP.
005518
010904
HEXACHLOROPHENE
LOAEL 0 75 MG/KG/DAY
ORAL: DIET
000070-30-4
DOG
13 WEEKS
NERVOUS SYSTEM EFFECTS
3E-3
300
IRIS
005972
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
1-58
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
HEXAHETHYLENE DIAMINE 000124-09-4
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(IHQ/CU m) (mg/kg/dav) _(iro/cu m) (ro/kg/dav)
UF UF UF UF
005973
HEXANE. N-
LOAEL 570 MG/KG/DAY
ORAL
000110-54-3
LOAEL 73 MG/CU M
INHALATION
INTERMITTENT
RAT
HUMAN
NERVOUS SYSTEM NEUROPATHY
TESTIS ATROPHY
6E-1
1000
2E-1
300
NERVOUS SYSTEM NEUROTOXICITY
SUBCHRONIC [RfC] COMMENT- THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC]
IRIS
6E-2
10000
005974
010273
HEXANONE, 2- 000591-78-6
GENERAL COMMENT, DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005976
SULFIDE
NOAEL 3 1 MG/KG/DAY
ORAL- FOOD
NOAEL 42 MG/CU M
INHALATION:
INTERMITTENT
007783-06-4
PIG
105 DAYS GASTRO- DISTURBANCE
INTESTINAL SYSTEM
MOUSE
13 WEEKS NASAL MUCOSA INFLAMMATION
3E-2
100
IRIS
IRIS
010269
010354
100
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLy ^URTHER INFORMATION. RISK INFORMATION HOTLINE. (513) 569-7254
1-59
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
HYDROQUINONE
NOAEL 4.29 MG/KG/DAY
ORAL
000123-31-9
HUMAN
3-5 MONTHS BLOOD
CRITICAL EFFECT
HEMATOLOGICAL EFFECTS
Subchronlc Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mg/kci/dayl (mg/cu m) (fnq/kq/dav)
UF UF UF UF
4E-1
10
4E-2
100
IRIS
CHRONIC RfC COMMENT THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (10/01/90) BY THE RfD/RfC WORK
005526
010905
IRON 007439-89-6
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ISOBUTYL ALCOHOL 000078-83-1
NOEL 316 MG/KG/DAY RAT
ORAL GAVAGE 13 WEEKS NERVOUS SYSTEM HYPOACTIVITY
NERVOUS SYSTEM ATAXIA
3E+0
100
IRIS
OQ55Z7
005977
ISOPHORONE 000078-59-1
NOEL 150 MG/KG/DAY DOG
ORAL- CAPSULE 90 DAYS KIDNEY
LESIONS
2E+0
100
IRIS
IRIS
GENERAL COMMENT ALSO SEE HEAST TABLE 3: CARCINOGENICITY
CHRONIC RfC COMMENT THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/15/90) BY THE RfD/RfC WORK GROUP
033820-53-0
ISOPROPALIN
NOEL 15 MG/KG/DAY RAT
ORAL DIET 90 DAYS
BLOOD
ORGANS,
UNSPECIFIED
HEMATOLIGICAL EFFECTS
ALTERED WEIGHTS
1.5E-1
100
IRIS
005910
010906
005978
LACTONITRILE 000078-97-7
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005783
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
1-60
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
[RfC]
(mq/cu m)
UF
Subchronic
[RfO]
(tng/kg/dav)
UF
Chronic
[RfC] [RfD]
(roq/gu m) (mq/kq/day)
UF UF
REFERENCE
LEAD 007439-92-1
CHRONIC [RfC] COMMENT REFER TO APPENDIX A TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
CHRONIC [RfD] COMMENT: REFER TO IRIS
GENERAL COMMENT ALSO SEE HEAST TABLE 3: CARCINOGENICITY,
010447
LEAD ALKYLS
CHRONIC [RfC] COMMENT. REFER TO APPENDIX A TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
CHRONIC [RfD] COMMENT: REFER TO IRIS
GENERAL COMMENT: DIMETHYLETHYL LEAD; METHYLTRIETHYL LEAD. TETRA8UTYL LEAD. TETRAETHYL LEAD; TETRAMETHYL LEAD,
TETRAPROPYL LEAD, TRIETHYL LEAD, TRIMETHYL LEAD. TRIMETHYLETHYL LEAD; TRIPROPYL LEAD
010448
LINURON 000330-55-2
LOAEL 0.625 MG/KG/DAY DOG
ORAL; DIET 2 YEARS BLOOD
HEMATOLOGICAL EFFECTS
2E-3
300
IRIS
005990
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT. ALSO SEE HEAST TABLE 3 CARCINOGENICITY
MALATHION 000121-75-5
NOEL 0 23 MG/KG/DAY HUMAN
ORAL CAPSULE 47 DAYS BLOOD
HEMATOLOGICAL EFFECTS
2E-2
10
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfC] COMMENT- UNDER REVIEW
IRIS
005991
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254.
1-61
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
lmg/cu_m) (mg/kQ/dav? (mg/cu m) (m/kg/day)
UF UF UF UF
MALEIC ANHYDRIDE 000108-31-6
NOAEL 10 MG/KG/DAY RAT
ORAL: DIET 2 YEARS KIDNEY
LESIONS
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfO WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
MALEIC HYDRAZIDE
LOAEL 500 MG/KG/DAY
ORAL DIET
000123-33-1
RAT
28 MONTHS KIDNEY
ALTERED FUNCTION
SUBCHRONIC [RfO] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
1E-1
100
5E-1
1000
IRIS
005992
IRIS
005993
MALONONITRILE
LGAEL 0.21 MG/KG/OAY
ORAL- GAVAGE
000109-77-3
RAT
120 DAYS LIVER
SPLEEN
EFFECTS
EFFECTS
2E-4
1000
2E-5
10000
005994
MANCOZEB
NOEL 2 9 MG/KG/DAY
ORAL: DIET
008018-01-7
RAT
90 WEEKS THYROID
GOITROGENIC EFFECTS
3E-2
100
3E-2
100
005995
MANEB
NOEL 5 MG/KG/OAY
ORAL- DIET
012427-38-2
MONKEY
6 MONTHS THYROID
INCREASED WEIGHT
100
IRIS
005996
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION RISK INFORMATION HOTLINE. (513) 569-7254,
1-62
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchrom'c Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ma/cu m) (mg/kg/day) £mq/cy m) (mg/kg/davj
UF UF UF UF
MANGANESE 007439-96-5
NQAEL 0.14 MG/KG/DAY HUMAN
ORAL: DIET CHRONIC
CENTRAL NERVOUS EFFECTS
SYSTEM
1 4E-1
1
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL FOOD RfD WAS ADOPTED AS THE SUBCHRONIC ORAL FOOD [RfD].
SEE IRIS FOR SPECIFIC DIETARY INFORMATION.
SUBCHRONIC [RfC] COMMENT. A SUBCHRONIC [RfC] HAS NOT BEEN DERIVED FOR MANGANESE.
IRIS
IRIS
010851
010959
HEPHOSFQLAN
NOEL 0.09 MG/KG/DAY
ORAL: DIET
000950-10-7
RAT
17 WEEKS LIVER
KIDNEY
BLOOD
ERYTHROCYTES
BRAIN
ALTERED WEIGHT
ALTERED WEIGHT
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
9E-4
100
9E-5 005997
1000
MERCURIC CHLORIDE
007487-94-7
RAT
ORAL; SUBCUTANEOUS
IMMUNE SYSTEM AUTOIMMUNE EFFECTS
3E-3
100
IRIS
005800
MERCURY, ELEMENTAL
NQAEL 0.009 MG/CU M
INHALATION.
007439-97-6
HUMAN
NERVOUS SYSTEM NEUROTOXICITY
CHRONIC [RfC] COMMENT REVIEW, CURRENT SUBJECT TO CHANGE.
3E-4
30
3E-4
30
010270
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-63
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
CHEMICAL DOSE SPECIES
LEVEL EXPERIMENT
TARGET
CRITICAL EFFECT
Subchromc Chrome
[RfC] [RfD] [RfC] [RfD]
(mq/cu m) (mq/kq/dav) imq/cu in) (mg/kq/dav)
UF UF UF UF
July 1997
REFERENCE
MERPHOS
NOEL 0 1 MG/KG/DAY
ORAL CAPSULE
000150-50-5
HEN
3 MONTHS
NERVOUS SYSTEM ATAXIA
NERVOUS SYSTEM DELAYED NEUROTOXICITY
WHOLE BODY DECREASED WEIGHT
3E-4
300
IRIS
005998
010907
CHRONIC [RfC] COMMENT THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP
SUBCHRONIC [RfD] CPMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfO]
MERPHOS OXIDE 000078-48-8
NOEL 0 1 MG/KG/DAY HEN
ORAL. CAPSULE 3 MONTHS NERVOUS SYSTEM ATAXIA
NERVOUS SYSTEM DELAYED NEUROTOXICITY
WHOLE BODY DECREASED WEIGHT
3E-4
300
IRIS
005999
010908
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP.
SUBCHRONIC [RfD] CPMMENT THE CHRONIC ORAL RfO WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfO].
HETHACRYLONITRILE
NOAEL 3 2 PPM
INHALATION
INTERMITTENT
000126-98-7
DOG
90 DAYS
LIVER
LIVER
CENTRAL NERVOUS
SYSTEM
BRAIN
INCREASED SGOT
INCREASED SGPT
LOSS OF HINDLIMB MOTOR CONTROL
LESIONS
1E-3
300
IRIS
005812
SUBCHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT. ON ROUTE TO ROUTE EXTRAPOLATION
CHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT ON ROUTE TO ROUTE EXTRAPOLATION
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. f513) 569-7254
1-64
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
METHANOL
NOEL 500 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000067-56-1
BLOOD
BLOOD
BRAIN
CRITICAL EFFECT
INCREASED ALKALINE PHOSPHATASE
INCREASED SGPT
DECREASED WEIGHT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(rro/cu m) Ong/kq/dgy} (mq/cy j) (ma/kq/dav)
UF UF UF UF
5E+Q
100
IRIS
010271
METHOMYL
NOEL 2.5 MG/KG/DAY
ORAL: DIET
016752-77-5
DOG
24 MONTHS KIDNEY
LESIONS
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
METHOXYCHLOR 000072-43-5
NOEL 5 01 MG/KG/DAY RABBIT
ORAL: GAVAGE 13 DAYS REPRODUCTION LOSS OF LITTERS
SU6CHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
2.5E-2
100
5E-3
1000
IRIS
IRIS
IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/07/91) BY THE RfD/RfC WORK GROUP
005802
010357
010909
METHOXYETHANOL ACETATE, 2- 000110-49-6
010497
CHRONIC [RfD] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfO] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: PISK INFORMATION HOTLINE (513) 569-7254.
1-6E
-------
HEAST TABLE 1; SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(ro/cu m) (inq/kg/jay)
UF UF
Chronic
[RfC] [RfD] REFERENCE
(ro/cu m) (mo/kg/day)
UF UF
METHOXYETHANOL, 2-
NOAEL 93 M6/CU M
INHALATION:
INTERMITTENT
000109-86-4
RABBIT
13 WEEKS
TESTICLE
EFFECTS
2E-1
100
IRIS
010372
SUBCHRONIC [RfD] COMMENT- ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE HETHOOS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINCGENICITY)
METHYL ACETATE
NOEL 1156 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000079-20-9
LIVER
LIVER
INCREASED ALKALINE PHOSPHATASE
INCREASED SGPT
1E+1
100
1E-H)
1000
010002
CHRONIC [RfD] COMMENT, CALCULATED FROM DATA OBTAINED WITH METHANOL BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (74 08/32 04),
METHYL ACRYLATE
000096-33-3
010498
CHRONIC [RfD] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
GENERAL COMMENT ALSO SEE HEAST TABLE 2- ALTERNATE METHODS -- SUBCHRQNIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL CHLOROCARBONATE 000079-22-1
CHRONIC [RfD] COMMENT, WITHDRAWN FROM IRIS (05/01/89).
GENERAL COMMENT- CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-66
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
[RfC]
Subchronlc
[RfD]
Chronic
[RfC] [RfD]
REFERENCE
TARGET
METHYL ETHYL KETONE
NOAEL 1711 MG/KG/DAY
ORAL DRINKING
WATER
000078-93-3
RAT
MULTI- FETUS
GENERATION
CRITICAL EFFECT
DECREASED BIRTH WEIGHT
(mg/cu m) (mq/kq/dav) (mq/cu m) (mq/kq/dav)
UF
UF
2E+0
1000
UF
UF
IRIS
010853
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfO WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT MULTI-GENERATION DEVELOPMENTAL STUDY PERFORMED WHT THE SURROGATE 2-BUTANOL. A METABOLITE OF METHYL ETHYL KETONE
NOAEL 1010 PPM MOUSE
INHALATION: 10 DAYS
INTERMITTENT
1E+0
3000
FETUS DECREASED BIRTH WEIGHT
SUBCHRONIC [RfC] COMMENT THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC]
IRIS
010845
METHYL ETHYL KETONE PEROXIDE 001338-23-4
CHRONIC [RfD] COMMENT- THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP
METHYL ISOBUTYL KETONE 000108-10-1
NOAEL 250 MG/(KG-DAY) RAT
ORAL- GAVAGE 13 WEEKS WHOLE BODY
LIVER
LIVER
KIDNEY
KIDNEY
KIDNEY
LETHARGY
INCREASED RELATIVE WEIGHT IN
FEMALES
INCREASED ABSOLUTE WEIGHT IN
FEMALES
INCREASED RELATIVE WEIGHT IN
FEMALES
INCREASED ABSOLUTE WEIGHT IN
FEMALES
INCREASED URINARY PROTEIN
LEVELS IN FEMALES
8E-1
300
8E-2
3000
010948
010949
SUBCHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT WITHDRAWN FROM IRIS (03/01/91), UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-67
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXIGITY (OTHER THAN CARCINOGENICITY)
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO]
(IKL/CU m) (nH/ka/dav) (mg/cu m) (ro/kg/dav)
UF UF UF UF
July 1997
REFERENCE
METHYL ISOCYANATE
000624-83-9
IRIS
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/18/90) BY THE RfD/RfC WORK GROUP.
METHYLMERCURY
CRITICAL ORAL DOSE
0.001 MG/KG/DAY
022967-92-6
HUMAN
DEVELOPMENTAL NEUROLOGICAL ABNORMALITIES
IN HUMAN INFANTS
1E-4
10
SUBCHRONIC [RfD] COHHENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfO] COMMENT. A BENCHMARK DOSE APPROACH WAS USED RATHER THAN A NOAEL/LOAEL TO DERIVE THE RfD.
IRIS
010013
010970
METHYL METHACRYLATE
NOEL 7 5 MG/KG/DAY
ORAL: WATER
METHYL PARATHION
NOAEL 2.5 PPM
ORAL- DIET
000080-62-6
RAT
24 KIDNEY
000298-00-0
RAT
90 DAYS
RELATIVE WEIGHT
ERYTHROCYTES CHOLINESTERASE INHIBITION
8E-2
100
2E-3
100
8E-2 010014
100
IRIS 010015
010846
METHYL STYRENE (MIXED ISOMERS) 025013-15-4
CHRONIC [RfD] COMMENT. UNDER REVIEW ALSO SEE HEAST TABLE 2. ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY}
GENERAL COMMENT- ALSO SEE HEAST TABLE 2' ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY}
010500
METHYL STYRENE. ALPHA
000098-83-9
GENERAL COMMENT- ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010499
IRIS EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. CURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254
1-68
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc
[RfC] [RfD]
(mg/cu m) (ma/ku/dav)
UF UF
Chrome
[RfC] [RfD] REFERENCE
(mg/cu m) (ma/ka/dav)
UF UF
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2- 000094-81-5
NOEL 12 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS LIVER EFFECTS
KIDNEY EFFECTS
ORAL. DIET
DOG
13 WEEKS
LIVER
KIDNEY
EFFECTS
EFFECTS
1E-1
100
IRIS
010008
METHYL-4-CHLOROPHENOXY) PROPIONIC ACID, 2-(2-
NOEL 3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS KIDNEY
000093-65-2
ALTERED WEIGHT
1E-2
300
IRIS
010009
METHYL-4-CHLOROPHENOXYACETIC ACID, 2- 000094-74-6
NOEL 0.15 MG/KG/DAY DOG
ORAL: DIET 52 WEEKS KIDNEY EFFECTS
LIVER EFFECTS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
5E-4
300
IRIS
010007
METHYLCYCLOHEXANE
NOAEL 287 MG/CU M
INHALATION
INTERMITTENT
RAT
1 YEAR
000108-87-2
KIDNEY
KIDNEY
MINERALIZATION
PAPILLARY HYPERPLASIA
3E+0
100
3E+C
100
010431
METHYLENE BROMIDE
000074-95-3
GENERAL COMMENT- ALSO SEE HEAST TABLE 2 ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010501
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
1-69
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kq/dav) (ma/cu m) (ma/ka/dav)
UF
UF
UF
UF
METHYLENE CHLORIDE (DICHLOROMETHANE)
NOAEL 5 85 MG/KG/DAY RAT
ORAL. DRINKING 24 MONTHS LIVER
WATER
000075-09-2
TOXICITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
NOAEL 694 8 MG/CU M RAT
INHALATION: 2 YEARS
INTERMITTENT
LIVER
TOXICITY
3E+0
100
GENERAL COMMENT ALSO SEE HEAST TABLE 3- CARCINOGENICITY.
METHYLENE-BIS(2-CHLOROANILINE), 4.4'- 000101-14-4
LOAEL 7.3 MG/KG/DAY DOG
ORAL 9 YEARS LIVER EFFECTS
BLADDER EFFECTS
6E-2
100
7E-4
10000
3E+0
100
IRIS
7E-4
10000
CHRONIC [RfC] COMMENT THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE 02/10/93) BY THE RfD/RfC WORK GROUP.
METHYLENEDIPHENYL ISOCYANATE, 4.4- (DIPHENYLMETHANE DIISOCYANATE) 000101-68-8
NOAEL 0.2 MG/CU M RAT
INHALATION- 24 MONTHS NASAL CAVITY LESIONS 2E-5
INTERMITTENT 300
IRIS
SUBCHRONIC [RfC] COMMENT THE CHRONIC INHALATION RfC ON IRIS WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
005553
005552
010413
010933
010449
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION' RISK INFORMATION HOTLINE. (513) 569-7254
1-70
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
METOLACHLOR
NOAEL 300 PPM
ORAL- DIET
051218-45-2
RAT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(TO/CU m) (mo/ka/dav) fmo/cu m) (mj/ko/dav)
UF UF UF UF
2 YEARS WHOLE BODY DECREASED WEIGHT GAIN
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUCHRONIC ORAL [RfD]
1 5E-1
100
1.5E-1 010950
100
METRIBUZIN
NOAEL 100 PPM
ORAL: DIET
021087-64-9
DOG
2 YEARS
LIVER
KIDNEY
WHOLE BODY
WHOLE BODY
EFFECTS
EFFECTS
MORTALITY
DECREASED WEIGHT
IRIS
010928
SUBCHRONIC [RfD] COMMENT- THE SUBCHRONIC ORAL [RfD] WAS REMOVED BECAUSE THE CHRONIC ORAL RfD UPON WHICH IT WAS BASED IS
UNDER REVIEW BY THE RfD/RfC WORK GROUP.
CHRONIC RfD COMMENT. THE CHRONIC ORAL RfD. WHILE STILL ON IRIS. IS BEING RECONSIDERED BY THE RfD/RfC WORK GROUP
MIREX
NOAEL 0.07 MG/KG/DAY RAT
ORAL DIET 2 YEARS
002385-85-5
LIVER
LIVER
LIVER
THYROID
CYTOMEGALY
FATTY METAMORPHOSIS
ANGIECTASIS
CYSTIC FOLLICLES
2E-4
300
IRIS
010841
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT- ALSO SEE HEAST TABLE 3 CARCINOGENICITY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM 15 UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254.
1-71
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/ka/dav) (mq/cu m) (mq/kg/dav)
UF UF UF UF
MOLINATE
NOEL 0 2 MG/KG/DAY
ORAL. GAVAGE
002212-67-1
RAT
REPRODUCTIVE TOXICITY
SYSTEM
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT BASED ON A REPRODUCTION STUDY.
MOLYBDENUM
LOAEL 0.14 MG/KG/DAY
ORAL: WATER.
DIET
HUMAN
007439-98-7
URINE
JOINTS
BLOOD
INCREASED URIC ACID
PAIN, SWELLING
DECREASED COPPER LEVELS
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RFD].
010599-90-3
MONOCHLORAMINE
NOAEL 9.5 MG/KG/DAY RAT
ORAL: DRINKING 2 YEARS
WATER
WHOLE BODY
LIVER
KIDNEY
WEIGHT CHANGES
WEIGHT CHANGES
WEIGHT CHANGES
2E-3
100
5E-3
30
1E-1
100
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
NAPHTHALENE 000091-20-3
CHRONIC [RfD] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300.
IRIS
IRIS
IRIS
010017
010489
010517
NAPHTHOQUINONE, 1.4- 000130-15-4
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
NICKEL CYANIDE 000557-19-7
CHRONIC [RfD] COMMENT- THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP
010020
010953
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-72
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL
LEVEL
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
[RfC]
(mg/cu m)
UF
Subchromc
[RfD]
(ro/kg/dav)
UF
Chronic
[RfC] [RfD]
(mg/cu m) (mg/kg/dav)
UF UF
REFERENCE
NICKEL, SOLUBLE SALTS VARIOUS
NOAEL 100 PPM RAT
ORAL. DIET 2 YEARS
WHOLE BODY
ORGANS. MAJOR
DECREASED WEIGHT
DECREASED WEIGHT
2E-2
300
IRIS
005579
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS DERIVED FROM NICKEL MOIETY OF ADMINISTERED NICKEL CHLORIDE.
NICOTINONITRILE
GENERAL COMMENT:
000100-54-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005584
NITRIC OXIDE 010102-43-9
CHRONIC [RfC] COMMENT. REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD HAS BEEN PERMANENTLY WITHDRAWN (09/01/94) FROM IRIS.
010451
NITRITE
NOEL 10 PPM
ORAL: WATER
HUMAN
014797-65-0
BLOOD
METHEMOGLOBINEMIA
1E-1
10
IRIS
SUBCHRONIC [RfD] COMMENT- THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN
POPULATION (INFANTS) THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN POPULATION (INFANTS).
010021
NITROANILINE, 2- 000088-74-4
CHRONIC [RfD] COMMENT THE CHRONIC ORAL [RFD] IS CONSIDERED NOT VERIFIABLE (06/23/92) BY THE RFD/RFC WORK GROUP
LOAEL 9.8 MG/CU M RAT
INHALATION- 4 WEEKS
INTERMITTENT
BLOOD
HEMATOLOGICAL EFFECTS
2E-3
1000
2E-4
10000
010936
010935
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATF? MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
1-73
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfO] [RfC] [RfDJ REFERENCE
(m/cu m) Lmq/kg/dav) (mq/cu m) (mq/kg/dav)
UF UF UF UF
NITROANILINE, H- 000099-09-2
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010400
NITROANILINE. P-
GENERAL COMMENT,
NITROBENZENE
LOAEL 25 MG/CU M
INHALATION-
INTERMITTENT
INHALATION;
INTERMITTENT
000100-01-6
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
MOUSE
90 DAYS
000098-95-3
BLOOD
ADRENAL
KIDNEY
LIVER
RAT
90 DAYS
BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
5E-3
1000
IRIS
010024
005589
SUBCHRONIC [RfC] COMMENT- ALSO SEE HEAST TABLE 2. ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2- ALTERNATE METHODS SUBCHRONIC AND CHRONICTOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfO] COMMENT THE ORAL RFO, WHILE STILL AVAILABLE ON IRIS, IS BEING RECONSIDERED BY THE RFO WORKGROUP. ON
TO ROUTE EXTRAPOLATION
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
NITROFURANTOIN
NOAEL 300 PPM
ORAL- DIET
000067-20-9
MOUSE
13 WEEKS
TESTIS
DAMAGE
7E-1
100
7E-2
1000
005593
IRIS. EPA'S INTEGRATED RIW 'NFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RIS< INFORMATION HOTLINE- (513) 569-7254.
1-74
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (ma/kg/dav) (mg/cu m) (mg/kg/dav)
UF UF UF UF
NITROGEN DIOXIDE 010102-44-0
CHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD HAS BEEN PERMANENTLY WITHDRAWN (09/01/94) FROM IRIS 010402
CHRONIC [RfC] COMMENT REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS 010912
NITROGEN OXIDES
CHRONIC [RfC] COMMENT- REFER TO APPENDIX A TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
010170
NITROMETHANE 000075-52-5
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010026
NITROPHENOLS
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005594
NITROPROPANE, 2-
LOAEL 78 MG/CU M
INHALATION.
INTERMITTENT
000079-46-9
RAT
22 MONTHS LIVER
LESIONS
2E-2
1000
IRIS
SUBCHRONIC [RfC] COMMENT THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
010374
NITROSODIPHENYLAMINE, P- 000156-10-5
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010027
NITROTOLUENE, M-
LOAEL 200 MG/KG/DAY
ORAL GAVAGE
000099-08-1
RAT
6 MONTHS
SPLEEN
LESIONS
1E-1
1000
SUBCHRONIC [RfD] COMMENT BASED ON DATA OBTAINED WITH 0-NITROTOLUENE
CHRONIC [RfD] COMMENT BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
1E-2
10000
010029
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTi'LY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
1-75
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(ma/ci[ m) (mq/kq/jay) Imq/cu m) tmq/kQ/dav)
UF UF UF UF
NITROTOLUENE, 0- 000088-72-2
LOAEL 200 MG/KG/DAY RAT
ORAL. GAVAGE 6 MONTHS SPLEEN
LESIONS
1E-1
1000
1E-2
10000
010028
NITROTOLUENE, P- 000099-99-0
LOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 6 MONTHS SPLEEN
LESIONS
SUBCHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH Q-NITRQTQLUENE
CHRONIC [RfD] COMMENT: ON DATA WITH G-NITROTOLUENE
1E-1
1000
1E-2
10000
010030
OCTABROMODIPHENYL ETHER 032536-52-0
NOAEL 2 5 MG/KG/DAY RAT
ORAL GAVAGE 90 DAYS LIVER
OCTAMETHYLPYROPHOSPHORAMIDE 000152-16-9
NOAEL 0.02 MG/KG/DAY HUMAN
ORAL AT LEAST 30 BLOOD
DAYS
HISTOLOGICAL CHANGES
DECREASED CHOLINESTERASE
ACTIVITY
3E~2
100
2E-3
10
IRIS
2E-3
10
"010032
010031
OSMIUH TETROXIDE 020816-12-0
CHRONIC [RfO] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
010954
OZONE 010028-15-6
CHRONIC [RfC] COMMENT REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
010171
PARALDEHYDE 000123-63-7
GENERAL COMMENT- DATA FOR QUANTITATIVE RISK ASSESSMENT
010033
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254
1-76
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mg/kg/dav) (mg/cu m) (mq/ka/dav)
UF UF UF UF
PARATHION
NOAEL 0 064 MG/KG/DAY
ORAL
000056-38-2
HUMAN
CHOLINESTERASE DECREASED CHOLINESTERASE
ACTIVITY
6E-3
10
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT: ALSO SEE HEAST TABLE 3. CARCINOGENICITY.
6E-3
10
005598
PARTICULATE MATTER
CHRONIC [RfC] COMMENT REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
010034
PEBULATE
NOEL 5 MG/KG/DAY
ORAL: DIET
001114-71-2
RAT
SUBCHRONIC BLOOD
INCREASED CLOTTING TIME
5E-2
100
5E-2
100
010036
PENDIMETHALIN 040487-42-1
NOEL 12.5 MG/KG/DAY DOG
ORAL: CAPSULE 2 YEARS LIVER
EFFECTS
4E-2
300
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS
010037
PENTABROMODIPHENYL ETHER 032534-81-9
NOAEL 1 8 MG/KG/DAY RAT
ORAL GAVAGE 90 DAYS LIVER
ALTERED ENZYME ACTIVITIES
2E-2
100
IRIS
010038
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-77
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIHENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(ITO/CU m) (mq/kq/dav) (mq/cum) (m/kq/day)
UF UF UF UF
PENTACHLOROBENZENE
LOAEL 8,3 MG/KG/DAY
ORAL- DIET
000608-93-5
RAT
100 DAYS LIVER
KIDNEY
TOXICITY
TOXICITY
8E-3
1000
IRIS
010039
PENTACHLOROCYCLOPENTADIENE 025329-35-5
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005302
PENTACHLORONITROBENZENE 000082-68-8
NOEL 0 75 MG/Kfi/DAY DOG
ORAL: DIET 2 YEARS LIVER
TOXICITY
3E-3
300
IRIS
010040
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT ALSO SEE HEAST TABLE 3. CARCINOGENICITY
PENTACHLOROPHENOL 000087-86-5
NOEL 3 MG/KG/DAY RAT
ORAL GAVAGE 62 DAYS FETUS
FETOTOXICITY
3E-2
100
IRIS
005600
SUBCHRONIC [RfD] ON A TERATOLOGY STUDY WITH 62 DAYS TO HATING AND GESTATION AND LACTATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3. CARCINOGENICITY
PENTACHLQROPROPENE, 1,1,2.3.3,- 001600-37-9
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010041
PENTANE. N- 000109-66-0
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005603
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-78
-------
HEAST TABLE 1: SUBCHRON1C AND CHRONIC TOX1CITY (OTHER THAN CARC1NOGEN1C1TY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (ma/ka/day) (mg/cu in) (ma/kg/dav)
UF UF UF UF
PHENANTHRENE 000085-01-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHRONIC [RfC] COMMENT- THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP.
005604
PHENOL
NOAEL 60 MG/KG/DAY
ORAL. GAVAGE
RAT
000108-95-2
FETUS
DECREASED WEIGHT
6E-1
100
IRIS
SUBCHRONIC [RfD] COMMENT: ON A DEVELOPMENTAL STUDY WITH EXPOSURES DAYS 6-15 OF GESTATION. THE ORAL
CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
IRIS
CHRONIC RfC COMMENT. THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (02/22/90) BY THE RfD/RfC WORK GROUP
005824
010913
PHENYLENEDIAMINE, M-
NOEL 6 MG/KG/LW
ORAL
000108-45-2
RAT
90 DAYS LIVER
LESIONS
6E-2
100
IRIS
010044
PHENYLENEDIAMINE, 0- 000095-54-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT ALSO SEE HEAST TABLE 3 CARCINOGENICITY.
010042
PHENYLENEDIAMINE, P-
NOAEL 18.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000106-50-3
WHOLE BODY
EFFECTS
1 9E-1
100
010043
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254.
1-79
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
LEVEL ROUTE LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(m/cu m) (mg/ko/dav) (mq/cu m) (im/kg/dav)
UF UF UF UF
PHENYLMERCURIC ACETATE 000062-38-4
NOAEL 0 0084 MG/KG/DAY RAT
ORAL DIET 2 YEARS KIDNEY
DAMAGE
8E-5
100
IRIS
010277
SUBCHRONIC [RfD] COHMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD] CALCULATED BY ANALOGY TO MERCURY BY CORRECTING
FOR DIFFERENCES IN MOLECULAR WEIGHT
CHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO MERCURY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
PHORATE 000298-02-2
NOAEL 0.033 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS
PHOSGENE
CHOLINESTERASE INHIBITION
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
000075-44-5
2E-4
200
2E-4 010403
200
IRIS
CHRONIC RfC CQMHENT THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (10/01/90) BY THE RfD/RfC WORK GROUP
010045
PHOSPHINE 007803-51-2
NOEL 0 026 MG/KG/DAY RAT
ORAL- DIET 2 YEARS
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
3E-4
100
IRIS
NOAEL 1 4 MG/CU M MOUSE
INHALATION: 13 WEEKS
INTERMITTENT
WHOLE BODY
WEIGHT
3E-3
100
IRIS
010174
010976
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLIf'E (513) 569-7254,
1-E
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mg/ka/day) (mo/cu m) (mg/ka/dav)
UF UF UF UF
PHOSPHORUS. WHITE 007723-14-0
GENERAL COMMENT: FORMERLY LISTED AS PHOSPHORUS (INORGANIC COMPOUNDS).
IRIS
010452
PHOTOCHEMICAL OXIDANTS
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
010172
PHTHALIC ACID. M- 000121-91-5
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010047
PHTHALIC ACID. 0- 000088-99-3
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PHTHALIC ACID, P- 000100-21-0
NOEL 142 MG/KG/DAY RAT
ORAL. DIET 2 YEARS BLADDER
HYPERPLASIA
1E+0
100
1E+0
100
010046
010048
PHTHALIC ANHYDRIDE
LOAEL 1562 MG/KG/DAY
ORAL. DIET
000085-44-9
MOUSE
104 WEEKS LUNG
KIDNEY
HISTOPATHOLOGY
HISTOPATHOLOGY
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
LOAEL 0 1 MG/CU M HUMAN
INHALATION 12 YEARS NOSE
INTERMITTENT LUNGS
RHINITIS
BRONCHITIS
1.2E-1
300
2E+0
1000
1 2E-1
300
SUBCHRONIC [RfC] COMMENT- THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC]
IRIS
010049
010847
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-81
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
jniq/cu m) (ro/kq/day) (ma/cu m) (mg/kg/dav)
UF UF UF UF
POLYBROMINATED BIPHENYLS
LOAEL 0.07 MG/KG/DAY RAT
ORAL. GAVAGE 25 WEEKS
LIVER
LIVER
INCREASED WEIGHT
LESIONS
GENERAL COMMENT- ALSO SEE HEAST TABLE 3. CARCINOGENICITY.
POTASSIUM CYANIDE
27 MG/KG/DAY RAT
ORAL. DIET 2 YEARS
000151-50-8
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
7E-5
1000
7E-6
10000
010050
5E-2
500
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
POTASSIUM SILVER CYANIDE
NOAEL 82 7 MG/KG/DAY RAT
ORAL- DIET 2 YEARS
000506-61-6
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
2E-1
500
IRIS
SU8CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT- CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
010278
010279
PROFLURALIN
NOEL 3 MG/KG/DAY
ORAL. DIET
026399-36-0
RAT
SUBCHRONIC
NONE OBSERVED
6E-3
500
6E-3
500
010051
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513 ' 569-7254
1-82
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARC1NOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(iro/cu in) (mq/kg/day) (mo/cu m) (mg/kg/dav)
UF UF UF UF
PRONAMIDE 023950-58-5
NOEL 7.5 MG/KG/DAY DOG
ORAL: DIET 2 YEARS NONE OBSERVED
SUBCHRONIC [RfO] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
PROPACHLOR
NOEL 13.3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS
001918-16-7
WHOLE BODY
DECREASED WEIGHT GAIN
PROPAZINE 000139-40-2
NOEL 5 MG/KG/DAY RAT
ORAL DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN
SUBCHRONIC [RfO] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
PROPIONITRILE 000107-12-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PROPYL ALCOHOL, N- 000071-23-8
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
7 5E-2
100
1.3E-1
100
2E-2
300
IRIS
IRIS
01D280
010175
IRIS 010052
010053
005627
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254
1-83
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIHENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
jnnq/cu mj (mq/ko/dav) (ma/cu. m) (mq/kq/dav)
UF UF UF UF
PROPYLENE GLYCOL 000057-55-6
NOEL 50000 PPM DOG
ORAL. DIET 2 YEARS
NOEL 6
ORAL: DIET
ERYTHROCYTES DECREASED COUNT
BLOOD DECREASED HEMATOCRIT
BLOOD DECREASED HEMOGLOBIN
RAT
20 WEEKS
KIDNEY
LESIONS
3E+1
100
IRIS
2E+1
100
CHRONIC RfC COMMENT, THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/25/91) BY THE RfD/RfC WORK GROUP
005631
005629
010914
PROPYLENE GLYCOL MONOETHYL ETHER 001569-02-4
NOEL 680 MG/KG/DAY RAT
ORAL DRINKING 30 DAYS WHOLE BODY
WATER
DECREASED WEIGHT GAIN
7E+0
100
7E-1
1000
IRIS
CHRONIC RfC COMMENT. THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/25/91) BY THE RfD/RfC WORK GROUP.
005488
010915
PROPYLENE GLYCOL MONOMETHYL ETHER
NOEL 947 MG/KG/DAY RAT
ORAL GAVAGE 35 DAYS
NOAEL 1000 PPM
INHALATION.
INTERMITTENT
000107-98-2
LIVER
KIDNEY
HISTOPATHOLOGY
HISTOPATHOLOGY
RAT. RABBIT
13 WEEKS CENTRAL NERVOUS EFFECTS
SYSTEM
7E+0
100
7E-1
1000
2E+1
30
IRIS
005486
010276
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7?54.
1-84
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(tro/cu m) (ma/kg/dav) (m/cu m) (mo/kg/day)
UF UF UF UF
PROPYLENE OXIDE
LOAEL 71 MG/CU M
INHALATION:
INTERMITTENT
000075-56-9
RAT
2 YEARS
EPITHELIUH
UNSPECIFIED
3E-2
100
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RFC]
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
010375
PYRENE 000129-00-0
NOAEL 75 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WKS KIDNEY
EFFECTS
3E-1
300
IRIS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP
010176
010968
PYRIDINE
NOAEL 1 MG/KG/DAY
ORAL. GAVAGE
000110-86-1
RAT
90 DAYS LIVER
LIVER
INCREASED WEIGHT
INCREASED RELATIVE WEIGHT
1E-2
100
IRIS
010055
RDX / (CYCLONITE)
NOEL 0 3 MG/KG/DAY
ORAL
000121-82-4
RAT
105 WEEKS PROSTATE
PROSTATE
INFLAMMATION
HEMOSIDEROSIS
3E-3
100
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT: ALSO SEE HEAST TABLE 3 CARCINOGENICITY.
IRIS
010056
RONNEL 000299-84-3
NOAEL 5 MG/KG/DAY RAT
ORAL DIET 2 YEARS LIVER
EFFECTS
5E-2
100
5E-2 010057
100
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254.
1-85
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE . SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (mg/cu m) (mg/kg/day)
UF UF UF UF
SELENIOUS ACID 007783-00-8
NOAEL 0.046 MG/KG/DAY HUMAN
ORAL: DIET WHOLE BODY SELENOS1S. CLINICAL
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
SELENIUM
NOAEL 0.853 MG/DAY
ORAL: DIET
007782-49-2
HUMAN
WHOLE BODY SELENQSIS, CLINICAL
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
SELENOUREA 000630-10-4
NOAEL 0 072 MS/KG/DAY HUMAN
ORAL- DIET WHOLE BODY
SELENOSIS
5E-3
3
5E-3
3
5E-3
15
CHRONIC [RfD] COMMENT WITHDRAWN FROM IRIS (05/01/91) UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SILVER
LOAEL 0.014 MG/KG/DAY
IV
007440-22-4
HUMAN
2-9 YEARS SKIN
ARGYRIA
5E-3
3
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT- BASED ON A TOTAL IV DOSE OF 1 GRAM
IRIS 010504
IRIS
5E-3
15
IRIS
010404
010473
010453
i:. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-86
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) July 1997
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfD] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mq/cu m) (mq/kq/dav) (mg/cu m) (mq/kq/dav)
UF UF UF UF
SILVER CYANIDE 000506-64-9
NOAEL 55.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 1E-1 IRIS 010283
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT. CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
SIMAZINE 000122-34-9
NOAEL 0.52 MG/(KG-DAY) RAT
-ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 5E-3 IRIS 010955
BLOOD HEMATOLOGICAL EFFECTS 100
SUBCHRONIC [RfD] COMMENT. THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT- ALSO SEE HEAST TABLE 3 CARCINOGENICITY
SODIUM CYANIDE 000143-33-9
NOAEL 20 4 MG/KG/DAY RAT
ORAL DIET CENTRAL NERVOUS EFFECTS 4E-2 IRIS 005640
SYSTEM 500
SUBCHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
CHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
NOEL 30 MG/KG/DAY RAT
ORAL 90 DAYS EYE CATARACTS 3E-1 IRIS 005644
WHOLE BODY DECREASED WEIGHT 100
GENERAL COMMENT ALSO SEE HEAST TABLE 3 CARCINOGENICITY
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 1-87
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
SODIUM METAVANADATE
NOAEL 10 PPM RAT
ORAL: DRINKING 3 MONTHS
WATER
TARGET
013718-26-8
KIDNEY
CRITICAL EFFECT
IMPAIRED FUNCTION
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(BIQ/CU m) (mq/kq/dav) (ro/cu m) (ma/kq/dav)
UF UF UF UF
1E-2
100
1E-3
1000
005735
STRONTIUM, STABLE 007440-24-6
NOAEL 190 MG/KG/DAY RAT. YOUNG
ORAL- DRINKING 20 DAYS BONE RACHITIC CHANGES
WATER
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
6E-1
300
IRIS
010842
STRYCHNINE
LOAEL 2 5 MG/KG/DAY RAT
ORAL GAVAGE 28 DAYS
000057-24-9
UNSPECIFIED
UNSPECIFIED
GENERAL COMMENT THE LOAEL IS ALSO THE FEL,
STYRENE
000100-42-5
NOAEL 22 PPM
INHALATION
OCCUPATIONAL
HUMAN
TOXICITY
HISTOPATHOLOGY
CENTRAL
NERVOUS SYSTEM
EFFECTS
3E-3
1000
IRIS
IRIS
3E+0
10
IRIS
CHRONIC [RfC] COMMENT THE MEAN DURATION OF EXPOSURE FOR 50 WORKERS WAS 8.6 YEARS AIR EXPOSURE CONCENTRATIONS WERE
ESTIMATED FROM THE SUMMATION OF THE PRINCIPLE URINARY METABOLITES OF STYRENE, MANOELIC ACID AND
PHENYLSLYOXYLIC ACID SEE IRIS FOR MORE INFORMATION.
GENERAL COMMENT ALSO SEE HEAST TABLE 3 CARCINOGENICITY
010285
010059
010511
SUCCINONITRILE 000110-61-2
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005585
MS. EPA'f INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURW INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254
1-E
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/dav) (mg/cu m) (mq/kg/day)
UF UF UF UF
SULFUR DIOXIDE 007446-09-5
CHRONIC [RfC] COMMENT REFER TO APPENDIX A- TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
010505
SULFUR OXIDES
CHRONIC [RfC] COMMENT- REFER TO APPENDIX A TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
010035
SULFURIC ACID
NOAEL 0 066-0.098 MG/CU M HUMAN
INHALATION
007664-93-9
RESPIRATORY
SYSTEM
RESPIRATORY EFFECTS
CHRONIC [RfC] COMMENT REPORTED EFFECTS OCCURRED AT PORTAL OF ENTRY. ESTIMATES OF MG/DAY REFERENCE DOSES ARE
INAPPROPRIATE BECAUSE EFFECTS AT PORTAL OF ENTRY DEPEND ON CONCENTRATION IN AIR AN ACCEPTABLE
AIR CONCENTRATION OF 0 07 MG/CU M WAS ESTIMATED BY CARSON ET AL (1981) FROM AVAILABLE DATA
005647
TEMEPHOS 003383-96-8
NOAEL 200 PPM RAT
ORAL- DIET 99 DAYS
2E-1
100
2E-2
1000
010060
TERBUFOS
NOAEL 0 0025 MG/KG/DAY
ORAL DIET
013071-79-9
DOG
6 MONTHS
CHOL1NESTERASE INHIBITION
2 5E-5
100
2 5E-5 010408
100
TEREPHTHALIC ACID 000100-21-0
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010474
TETRACHLOROAZOXYBENZENE 021232-47- 3
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010064
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEt-'. IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE: (513) 569-7254.
l-t
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subehromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) Iro/kg/day) (ro/cu m) (mo/kg/day)
UF UF UF UF
TETRACHLQROBENZENE, 1,2,4,5- 000095-94-3
NQAEL 0.34 MG/KG/DAY RAT
ORAL DIET 13 WEEKS KIDNEY
LESIONS
3E-3
100
IRIS
010286
TETRACHLOROCYCLOPENTADIENE 000695-77-2
GENERAL COMHENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005303
TETRACHLOROETHANE, 1,1,1,2- 000630-20-6
LOAEL 89 3 MG/KG/DAY RAT
ORAL GAVAGE 103 WEEKS LIVER
KIDNEY
LESIONS
LESIONS
3E-2
3000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TETRACHLOROETHYLENE
NOAEL 14 MG/KG/DAY
ORAL
000127-18-4
MOUSE
6 WEEKS LIVER
HEPATOTOXICITY
1E-1
100
GENERAL COMMENT- ALSO SEE HEAST TABLE 3- CARCINOGENICITY.
IRIS 010407
IRIS
TETRACHLOROHYDRAZOBENZENE 071753-42-9
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010065
TETRACHLOROPHENOL, 2,3,4,5- 004901-51-3
GENERAL COMMENT. DATA FOR QUANTITATIVE RISK ASSESSMENT
005324
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE. (513) 569-7254
1-90
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mq/kq/dav) (mq/cu m) (mq/kg/dav)
UF UF UF UF
TETRACHLOROPHENOL. 2.3.4.6- 000058-90-2
NOAEL 25 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER
LIVER
INCREASED WEIGHT
CENTRILOBULAR HYPERTROPHY
3E-1
100
IRIS
005323
TETRACHLOROPHENOL. 2.3.5.6- 000935-95-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005325
TETRACHLOROPROPENE, 1.1.2,3- 010436-39-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010066
TETRACHLOROVINPHOS / (STIROPHOS)
NOEL 3.1 MG/KG/DAY DOG
ORAL: DIET 2 YEARS
000961-11-5
LIVER
KIDNEY
WHOLE BODY
INCREASED WEIGHT
INCREASED WEIGHT
3E-2
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010067
TETRAETHYL DITHIOPYROPHOSPHATE 003689-24-5
NOEL 0.5 MG/KG/DAY RAT
ORAL: DIET 3 MONTHS ERYTHROCYTES
BLOOD
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
5E-3
100
IRIS 010287
THALLIC OXIDE 001314-32-5
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP
010956
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1-91
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subehronic
[RfC] [RfD]
(mq/cu ml (mq/kg/day)
UF UF
Chronic
[RfC] [RfD]
(mq/cu rn) (mq/kQ/dayj
UF UF
REFERENCE
THALLIUM (I) ACETATE
NOAEL 0 26 MG/KG/DAY RAT
ORAL 90 DAYS
000563-68-8
LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
9E-4
300
IRIS
SUBCHRONIC [RfD] COMMENT. CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES,
CHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I) CARBONATE
NOAEL 0 23 MG/KG/DAY RAT
ORAL 90 DAYS
006533-73-9
LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
8E-4
300
IRIS
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES
CHRONIC [RfD] COMMENT. CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I) CHLORIDE
NOAEL 0.23 MG/KG/DAY RAT
ORAL 90 DAYS
007791-12-0
LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
8E-4
300
IRIS
SUBCHRONIC [RfO] COMMENT, CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT. CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES
005664
005668
005672
THALLIUM, INSOLUBLE SALTS
CHRONIC [RfD] COMMENT. REFER TO IRIS FOR OTHER THALLIUM SALTS.
010458
IRIS. EPA'5 INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION RISK INFORMATION HOTLINE: (513)569-7254.
1 92
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
DOSE SPECIES
ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(ro/cu m) (rro/kq/dav)
UF UF
Chronic
[RfC] [RfD] REFERENCE
(mg/cu m) (im/kg/dav)
UF UF
THALLIUM (I) NITRATE
NOAEL 0.26 MG/KG/DAY RAT
ORAL 90 DAYS
010102-45-1
LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
9E-4
300
IRIS
005676
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES
THALLIUM SELENITE
012039-52-0
010957
CHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS WITHDRAWN FROM IRIS (08/01/93). THE CHRONIC ORAL [RfD] IS
CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP
THALLIUM (I) SULFATE
NOAEL 0 25 MG/KG/DAY RAT
ORAL 90 DAYS
007446-18-6
LIVER
BLOOD
HAIR
INCREASED SGOT
INCREASED SERUM LDH
ALOPECIA
8E-4
300
IRIS
005682
THIOCYANOMETHYLTHIO)BENZOTHIAZOLE, 2-(
NOEL 25 MG/KG/DAY RAT
ORAL DIET SUBCHRONIC STOMACH
021564-17-0
LESIONS
3E-1
100
010068
1000
SUBCHRONIC [RfD] COMMENT BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
CHRONIC [RfD] COMMENT- BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-93
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
jjmq/cu m). (mg/kg/dav) (ro/cu m) (rog/kg/dav)
UF UF UF UF
THIOFANOX
NOAEL 0 025 MG/KG/DAY DOG
ORAL 8 DAYS
013196-18-4
CHOLINESTERASE DECREASED CHQLINESTERASE
ACTIVITY
SUBCHRONIC [RfO] COMMENT. BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
CHRONIC [RfO] COMMENT. ON CONFIDENTIAL BUSINESS INFORMATION DATA
THIRAM
000137-26-8
NOAEL 0.61 MG/KG/QAY FERRET
ORAL 24
TIN AND COMPOUNDS
NOAEL 2000 PPM RAT
ORAL: DIET 2 YEARS
REPRODUCTION
IMPAIRED
LIVER
KIDNEY
LESIONS
LESIONS
3E-4
100
3E-4
100
100
6E-1
100
6E-1
100
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
TOLUENE
NOAEL 223 MG/KG/DAY
ORAL. GAVAGE
000108-88-3
RAT
13 WEEKS LIVER
KIDNEY
ALTERED WEIGHT
ALTERED WEIGHT
2E+0
100
IRIS
IRIS
SUBCHRONIC [RfC] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300
010069
IRIS 010459
010070
005688
010469
010844
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-94
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(mq/cu m) (ma/ka/dav)
UF UF
Chronic
[RfC] [RfD] REFERENCE
(mq/cu m) (mg/ka/dav)
UF UF
TOLUENE-2.5-DIAMINE
NOAEL 56 MG/KG/DAY
ORAL: DIET
000095-70-5
RAT
78 WEEKS
SUBCHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
CHRONIC [RfD] COMMENT- DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
TOLUENE-2.6-DIAMINE 000823-40-5
NOAEL 16 MG/KG/DAY RAT
ORAL DIET 2 YEARS
SUBCHRONIC [RfD] COMMENT DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE
CHRONIC [RfD] COMMENT- DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE
6E-1
100
2E-1
100
6E-1 010073
100
2E-1 010074
100
TOLUENEDIAMINE. 2.3- 002687-25-4
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010071
TOLUENEDIAMINE, 3,4- 000496-72-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010072
TOLUIDINE. M- 000108-44-1
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010075
TRIALLATE
NOAEL 1 275 MG/KG/DAY
ORAL. DIET
002303-17-5
DOG
24 MONTHS SPLEEN
LIVER
EFFECTS
EFFECTS
1.3E-2
100
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
IRIS
010076
IPIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY FURTHER INFORMATION. RISK INFORMATION HOTLINE (513) 569-7254
1-95
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Chronic
July 1997
CHEMICAL OQ5E SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
Subchronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
CRITICAL EFFECT (mg/cu m) (mq/kq/dav) (m/cu m) (mq/kq/dav)
UF UF UF UF
TRIBROMOBENZENE, 1,2,4- 000615-54-3
NOAEL 5 Mfi/KG/DAY RAT
ORAL. DIET 45 OR 90 LIVER
DAYS LIVER
ALTERED WEIGHT
ENZYME INDUCTION
5E-2
100
IRIS
010077
TRICHLORO-1.2.2-TRIFLUOROETHANE, 1,1,2- 000076-13-1
NOEL 2000 PPM RAT
INHALATION. 24 MONTHS
INTERMITTENT
WHOLE BODY
DECREASED WEIGHT
3E+1
100
3E+0
100
SUBCHRONIC [RfO] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.2
3E+1
100
IRIS
010460
010376
TRICHLORO-2'-HYDROXYDIPHENYLETHER, 2,2,4'-
NOEL 500 MG/KG/QAY RAT
ORAL 4 WEEKS WHOLE BODY
003380-34-5
DECREASED WEIGHT
4E+0
100
005492
TRICHLOROBENZENE, 1,2,4- 000120-82-1
NOAEL 100 PPM RAT
ORAL DRINKING ADRENAL
WATER
INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT BASED ON A MULTIGENERATION REPRODUCTION STUDY
NOAEL 104 PPM
INHALATION
RAT, RABBIT,
DOG, MONKEY
6 AND 26 LIVER
WEEKS
g-ADVERSE WEIGHT CHANGES
1000
2E+0
100
2E-1
1000
IRIS
010506
010958
TRICHLOROCYCLOPENTADIENE 077323-84-3
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005304
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
1-96
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (ma/ka/dav) (mg/cu m) (mg/kq/dav)
UF UF UF UF
TRICHLOROETHANE, 1,1.1- 000071-55-6
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
TRICHLOROETHANE, 1.1.2-
NOAEL 3.9 MG/KG/DAY
ORAL. DRINKING
WATER
000079-00-5
MOUSE
90 DAYS
BLOOD CLINICAL CHEMISTRY ALTERATIONS
GENERAL COMMENT: ALSO SEE HEAST TABLE 3 CARCINOGENICITY
4E-2
100
IRIS
005702
TRICHLOROFLUOROMETHANE
LOAEL 1000 MG/KG/DAY
ORAL
000075-69-4
RAT
6 WEEKS
WHOLE BODY
INCREASED MORTALITY
7E-1
1000
IRIS
005502
005500
SUBCHRONIC [RfC] COMMENT- ALSO SEE HEAST TABLE 2' ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT ALSO SEE HEAST TABLE 2 ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
TRICHLOROPHENOL, 2.3,4- 015950-66-0
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005330
TRICHLOROPHENOL, 2,3.5- 000933-78-8
GENERAL COMMENT DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005331
TRICHLOROPHENOL. 2.3,6- 000933-75-5
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005332
IRIS. EPA-'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
1-97
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
July 1997
LEVEL
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfO] REFERENCE
(mq/cu m) (ro/kq/dayj (mg/cu m) (ro/kg/dav)
UF UF UF LIF
TRICHLOROPHENOL. 2,4,5- 000095-95-4
NOEL 1000 PPM RAT
ORAL. DIET 98 DAYS LIVER
KIDNEY
HEPATOTOXIC1TY
EFFECTS
1E+0
100
IRIS
TRICHLOROPHENOL, 2,4,6-
000088-06-2
IRIS
CHRONIC RfC COMMENT THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/24/91) BY THE RfO/RfC WORK GROUP.
COMMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY,
005329
IRIS 010919
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/24/91) BY THE RfO/RfC WORK GROUP,
010461
TRICHLOROPHENOL, 3.4,5- 000609-19-8
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005333
TRICHLOROPHENOXY) PROPIONIC ACID, 2(2,4,5- 000093-72-1
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER HISTOPATHOLOGY
SUBCHRONIC [RfD] COMMENT- THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
8E-3
100
IRIS 010284
TRICHLOROPHENOXYACETIC ACID. 2.4,5- 000093-76-5
NOEL 10 M6/KG/OAY RAT
ORAL: DIET 90 DAYS
KIDNEY
LIVER
WEIGHT EFFECTS
WEIGHT EFFECTS
1E-1
100
TRICHLOROPROPANE, 1.1.1- 007789-89-1
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
IRIS 010178
010179
005705
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE' (513) 569-7254.
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu rnj (mo/kg/dav) (im/cu in) (mq/kq/dav)
UF UF UF UF
TRICHLOROPROPANE, 1,1,2- 000598-77-6
NOEL 100 MG/L RAT
ORAL. DRINKING 13 WEEKS LIVER
WATER KIDNEY
THYROID
HISTOPATHOLOGY
HISTOPATHOLOGY
HISTOPATHOLOGY
5E-2
300
IRIS
005708
TRICHLOROPROPANE, 1,2,2-
GENERAL COMMENT.
003175-23-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005706
TRICHLOROPROPANE, 1,2,3- 000096-18-4
NOAEL 8 MG/KG/DAY RAT
ORAL 120 DAYS
WHOLE BODY
LIVER
KIDNEY
ERYTHROCYTES
BLOOD
BLOOD
TOXICITY
LESIONS
LESIONS
DECREASED COUNT
DECREASED HEMATOCRIT
DECREASED HEMOGLOBIN
GENERAL COMMENT- ALSO SEE HEAST TABLE 3' CARCINOGENICITY.
TRICHLOROPROPENE, 1.2,3-
NOEL 18 MG/CU H
INHALATION.
INTERMITTENT
000096-19-5
DOG
66 WEEKS
EYE
IRRITATION
6E-2
100
IRIS 005714
5E-3
100
5E-3 010078
100
SUBCHRONIC [RfD] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY FURTHER INFORMATION RISK INFORMATION HOTLINE: (513) 569-7254.
1-99
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY) July 1997
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfD] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mq/cu m) (mq/kq/dav) (mq/cu m) (mq/kq/dav)
UF UF UF UF
TRICHLOROTOLUENE, 2.3.6- 002077-46-5
LOAEL 0.5 PPM RAT
ORAL- DIET 28 DAYS LIVER LESIONS 5E-5 005335
KIDNEY LESIONS 1000
THYROID LESIONS
TRICHLOROTOLUENE. ALPHA.2,6- 002014-83-7
LOAEL 0.5 PPM RAT
ORAL- DIET 28 DAYS LIVER LESIONS 5E-5 005339
KIDNEY LESIONS 1000
THYROID LESIONS
TRIFLURALIN 001582-09-8
NOEL 0.75 MG/KG/DAY DOG
ORAL- DIET '12 MONTHS LIVER INCREASED WEIGHT 7 5E-3 IRIS 010080
BLOOD METHEMOGLOBINEMIA 100
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3. CARCINOGENICITY
TRIMETHYLBENZENES
GENERAL COMMENT- DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005727
TRINITROBENZENE. 1.3.5- 000099-35-4
NOAEL 0 51 MG/KG/DAY RAT
ORAL: WATER 16 WEEKS SPLEEN INCREASED WEIGHT 5E-4 IRIS 010081
1000
SUBCHRONIC [RfD] COMMENT- CALCULATED FROM DATA OBTAINED WITH 1.3-DINITROBENZENE.
CHRONIC [RfD] COMMENT- CALCULATED FROM DATA OBTAINED WITH 1.3-DINITROBENZENE.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254 1-100
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chrome
[RfC] [RfD] [RfC] [RfD] REFERENCE
(rro/cu m) (mq/kq/dav) (mg/cy m) (mq/kq/dav)
UF UF UF UF
TRINITROPHENOLS
GENERAL COMMENT. DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010082
TRINITROPHENYLMETHYLNITRAMINE 000479-45-8
LOAEL 125 MG/KG/DAY RABBIT
ORAL: GAVA6E 9 MONTHS LIVER
KIDNEY
SPLEEN
HISTOPATHOLOGICAL EFFECTS
HISTOPATHOLOGICAL EFFECTS
HISTOPATHOLOGICAL EFFECTS
1E-1
1000
1E-2 010377
10000
TRINITROTOLUENE. 2.4.6-
LOAEL 0,5 MG/KG/DAY
ORAL: GAVAGE
DOG
000118-96-7
LIVER
EFFECTS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
GENERAL COMMENT ALSO SEE HEAST TABLE 3. CARCINOGENICITY
5E-4
1000
IRIS .010416
VANADIUH 007440-62-2
NOAEL 5 PPM RAT
ORAL: DRINKING LIFETIME
WATER
7E-3
100
7E-3
100
005739
VANADIUM PENTOXIDE
NOAEL 17 85 PPM
ORAL: DIET
001314-62-1
RAT
LIFETIME
SUBCHRONIC [RfD] COMMENT. THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
9E-3
100
IRIS
005743
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
1 101
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL
DQSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
VANADIUM SULFATE 036907-42-3
NOAEL 2.24 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME
WATER
VERNAM,/ (VERNOLATE)
NOEL 1 MG/KG/DAY
ORAL: DIET
VINYL ACETATE
NOAEL 100 MG/KG/DAY
ORAL WATER
RAT
RAT
2 YEARS
001929-77-7
WHOLE BODY
000108-05-4
WHOLE BODY
KIDNEY
NOAEL 176 MG/CU M
INHALATION
INTERMITTENT
HOUSE
104 WEEKS
CRITICAL EFFECT
DECREASED WEIGHT
ALTERED WEIGHT
ALTERED WEIGHT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mo/kg/dav) (mg/cu m) (mg/kq/dav)
005747
NASAL CAVITY LESIONS
SUBCHRONIC [RfC] COMMENT- THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC)
UF UF
2E-2
100
1E-2
100
1E+0
100
2E-1
30
UF UF
2E-2 i
100
IRIS i
1E+0 (
100
IRIS I
010083
010417
010418
VINYL CHLORIDE 000075-01-4
SUBCHRONIC [RfC] COMMENT. CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300
SUBCHRONIC [RfO] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300
GENERAL COMMENT- ALSO SEE HEAST TABLE 3. CARCINOGENICITY,
VINYL-1-CYCLOHEXENE, 4- 000100-40-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010084
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION RISK INFORMATION HOTLINE: (513 > 569-7254.
1-102
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(roa/cu m) {fq/kg/davl (mq/cu in) (mq/kq/dav)
UF UF UF UF
WARFARIN
LOAEL 2 MG/OAY
ORAL
HUMAN
000081-81-2
BLOOD
INCREASED PRQTHROMBIN TIME
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfO].
3E-4
100
IRIS
XYLENE, M-
NOAEL 250 MG/KG
ORAL GAVAGE
000108-38-3
RAT
103 WEEKS CENTRAL NERVOUS HYPERACTIVITY
SYSTEM
WHOLE BODY DECREASED WEIGHT
BODY
100
SUBCHRONIC [RfD] COMMENT. CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER- (513) 569-7300
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK
IRIS
XYLENE, MIXTURE 001330-20-7
SUBCHRONIC [RfO] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300,
CHRONIC [RfC] COMMENT; THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
XYLENE, 0-
NOEL 250 MG/KG
ORAL GAVAGE
000095-47-6
RAT
103 WEEKS CENTRAL NERVOUS HYPERACTIVITY
SYSTEM
WHOLE BODY DECREASED WEIGHT
2E+0
100
SUBCHRONIC [RfD] COMMENT. CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER- (513) 569-7300.
CHRONIC [RfC] COMMENT THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP
010409
005755
010920
010872
010921
005751
010922
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
1-103
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL DQSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchromc Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (rro/kq/dav) (ma/gnu) .(na/ka/dav)
UF UF UF UF
XYLENE, P- 000106-42-3
SUBCHRONIC [RfD] COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER- (513) 569-7300
CHRONIC [RfC] COMMENT. THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
010923
ZINC (METALLIC)
LOAEL 1.0 MG/KG/QAY
ORAL: DIET
SUPPLEMENT
007440-66-6
HUMAN
10 WEEKS
BLOOD
DECREASED BLOOD ENZYME
CHRONIC [RfD] COMMENT THE CHRONIC ORAL RfO WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
3E-1
3
IRIS
010937
ZINC CYANIDE
NOAEL 24 3 MG/KG/DAY RAT
ORAL. DIET 2 YEARS
000557-21-1
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
5E-2
500
IRIS
SUBCHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT
010289
ZINC PHOSPHIDE
LOAEL 3,48 MG/KG/DAY
ORAL: DIET
001314-84-7
RAT
13 WEEKS WHOLE BODY
WHOLE BODY
DECREASED WEIGHT
DECREASED FOOD INTAKE
3E-3
1000
IRIS
010290
ZINEB
LOAEL 25 MG/KG/DAY
ORAL, DIET
012122-67-7
RAT
2 YEARS THYROID
HYPERPLASIA
5E~2
500
SUBCHRONIC [RfD] COMMENT THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
IRIS
010085
IRIS EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY rURTHER INFORMATION- RISK INFORMATION HOTLINE: (513)569-7254
1-104
-------
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN!CITY) July 1997
ACENAPHTHENE 000083-32-9
010165 US EPA 1989 MOUSE ORAL SUBCHRONIC STUDY WITH ACENAPHTHENE. STUDY CONDUCTED BY HAZELTON LABORATORIES. INC . FOR THE OFFICE OF SOLID
WASTE. WASHINGTON. DC
US EPA. 1989 RfO/RfC WORK GROUP
ACENAPHTHYLENE 000208-96-8
005202 US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR ACENAPHTHYLENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
ACEPHATE 030560-19-1
005833 CHEVRON CHEMICAL COMPANY 1987 CONFIDENTIAL BUSINESS INFORMATION UNPUBLISHED DATA MRID NO 40504819
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACEPHATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1989 RfD/RfC WORK GROUP
ACETONE 000067-64-1
005204 US EPA 1986 NINETY-DAY GAVAGE STUDY IN ALBINO RATS USING ACETONE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1988 UPDATED HEALTH EFFECTS ASSESSMENT FOR ACETONE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1986 RfO/RfC WORK GROUP
ACETONE CYANOHYDRIN / (METHYLLACTONITRILE) 000075-86-5
005776 HAZELTON LABORATORIES AMERICA 1988 SUBCHRONIC TOXICITY STUDY IN RATS WITH 2-METHYLLACTONITRILE HLA STUDY NO 2399-114 REPORT PREPARED
FOR DYNAMAC CORPORATION
US EPA 1994 RfD/RfC WORK GROUP
ACETONITRILE 000075-05-8
005210 NATIONAL TOXICOLOGY PROGRAM (NTP) 1983 90-DAY SUBCHRONIC TOXICITY STUDIES OF ACETONITRILE IN RATS AND MICE REPORT TO NATIONAL
TOXICOLOGY PROGRAM.
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR ACETONITRILE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC
US EPA 1987 RfD/RfC WORK GROUP
Rl-1
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ACETOPHENONE 000098-86-2
HAGAN, EC, WH HANSEN, DG FITZHUGH. ET AL. 1967 FOOD FLAVORINGS AND OF RELATED STRUCTURE II. SUBACUTE AND CHRONIC TOXICITY,
FOOD COSMET TOXICOL 5(2): 141-157
US EPA 1987. RfD/RfC WORK GROUP.
010874 US EPA 1992 RfD/RfC WORK GROUP
ACRQLEIN 000107-02-8
010390 NEWELL GW. 1958 ACUTE AND SUBACUTE TOXICITY OF ACROLEIN STANFORD RESEARCH INSTITUTE. SRI PROJECT NO. 5-868-2.
MAS (NATIONAL ACADEMY OF SCIENCES). 1977. DRINKING WATER AND HUMAN HEALTH. WASHINGTON, DC
US EPA. 1985. HEALTH AND ENVIRONHENTAL EFFECTS PROFILE FOR ACROLEIN. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
010856 FERON VJ. A KRUYSSE. HP TIL, AND HR IMMEL 1978. REPEATED EXPOSURE TO ACROLEIN VAPOR. SUBACUTE STUDIES IN HAMSTERS. RATS AND RABBITS.
TOXICOLOGY. 9- 47-57.
US EPA 1991 RfD/RfC WORK GROUP.
ACRYLAMIOE 000079-06-1
005835 BUREK JD, RR ALBEE, JE BEYER. ET AL. 1980 SUBCHRONIC TOXICITY OF ACRYLAMIDE ADMINISTERED TO RATS IN THE DRINKING WATER FOLLOWED BY UP TO
144 DAYS OF RECOVERY J ENVIRON PATHOL TOXICOL. 4. 157-182.
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACRYLAMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1988. RFD/RFC WORK GROUP.
010876 US EPA. 1990 RfD/RfC WORK GROUP
Rl-Z
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
ACRYLIC ACID 000079-10-7
005836 BASF. 1993. REPRODUCTION TOXICITY STUDY WITH ACRYLIC ACID IN RATS- CONTINUOUS ADMINISTRATION IN THE DRINKING WATER OVER 2 GENERATIONS
(1 LITTER IN THE FIRST AND 1 LITTER IN THE SECOND GENERATION) PROJECT NO 71R0114/92011. BASF AKTIENGELLSCHAFT, DEPT. OF TOXICOLOGY.
RHEIN. FRG.
US EPA 1994. RfD/RfC WORK GROUP
010346 MILLER. RR. JA AYERS. GC JERSEY AND MJ MCKENNA 1981. INHALATION TOXICITY OF ACRYLIC ACID FUND APPL TOXICOL 1(3) 271-277.
MILLER. RR. JA AYERS. GC JERSEY. 1979 ACRYLIC ACID 90-DAY VAPOR INHALATION STUDY WITH RATS AND MICE FINAL REPORT #79RC-1024 TOXICOLOGY
RESEARCH LABORATORY. HEALTH AND ENVIRONMENTAL SCIENCE. DOW CHEMICAL COMPANY. MIDLAND. MI.
US EPA. 1990. RfD/RfC WORK GROUP.
ACRYLONITRILE 000107-13-1
010939 TANDON R. DK SAXENA. SV CHANDRA. PK SETH. SP SRIVASTAVA 1988. TESTICULAR EFFECTS OF ACRYLONITRILE IN MICE TOXICOLOGY LETTERS. 42
55-63
BIODYNAMICS 1980. A TWENTY-FOUR MONTH ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED TO SPARTAN RATS IN THE DRINKING
WATER. VOL 1-2 PREPARED BY BIODYNAMICS. INC.. DIVISION OF BIOLOGY AND SAFETY EVALUATION. EAST MILLSTONE. NJ. FOR MONSANTO COMPANY. ST
LOUIS. MO.
US EPA 1993 RfD/RfC WORK GROUP.
ADIPONITRILE 000111-69-3
005157 US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ADIPONITRILE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
ALACHLOR 015972-60-8
005837 MONSANTO CO 1984. MRID NO 00148923. AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC. 20460.
US EPA. 1992 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ALACHLOR PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE OF THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALACHLOR PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
US EPA. 1991. RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ALDICARB 000116-06-3
RHONE-PQULENC AG 1992. MRID NO 423730-01. HED DOC NO 010459 AVAILABLE FROM EPA WRITE TO FOI, EPA, WASHINGTON, DC
UNION CARBIDE CORP 1971. R HAINES, JB OERNEHL, JB BLOCK. SUPERVISING PHYSICIANS INGESTION OF ALDICARB BY HUMAN VOLUNTEERS A CONTROLLED
STUDY OF THE EFFECTS OF ALDICARB ON MAN ALD-03-77-2215 FEB 11. 1971 MRID NO 00101911 HED DOC NO 010450 AVAILABLE FROM EPA WRITE TO
FOI, EPA, WASHINGTON, DC 20460.
GOLDMAN LR. M SELLER. RJ JACKSON 1990 ALDICARB FOOD POISONING IN CALIFORNIA. 1985-1988. TOXICITY ESTIMATES FOR HUMANS ARCH ENVIRON
HEALTH. 45(3): 141-147. HED DOC NO 010451. 010455. 010458. AVAILABLE FROM EPA WRITE TO FOI, EPA. WASHINGTON, DC 20460
GOLDMAN, LR, DF SMITH, RR NEUTRA ET AL 1990 PESTICIDE FOOD POISONING FROM CONTAMINATED WATERMELONS IN CALIFORNIA. 1985 ARCH ENVIRON
HEALTH 45(4) 229-236
HIRSCH GH. BT MORI. GB PR BC WILLIAMS 1987 OF ILLNESSES CAUSED BY ALDICARB-CONTAHINATED FOOD
ADDITIVES AND CONTAMINANTS 5(2) 155-60 HED DOC NO 010455, 010458. AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON, DC 020460
US EPA 1992. RfD/RfC WORK GROUP
ALDRIN 000309-00-2
005159 FITZHUGH OG. AA NELSON AND ML QUAIFE 1964. CHRONIC ORAL TOXICITY OF ALDRIN AND DIELDRIN IN RATS AND DOGS FOOD COSMET TOXICOL 2
551-562
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR ALDRIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
US EPA. 1985 RfD/RfC WORK GROUP.
ALLIDOCHLOR 000093-71-0
005838 US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLIDOCHLOR PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
ALLYL ALCOHOL 000107-18-6
005839 CARPANINI FMB. IF GAUNT, J HARDY, ET AL. 1978 SHORT-TERM TOXICITY OF ALLYL ALCOHOL IN RATS TOXICOLOGY 9' 29-45
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL ALCOHOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1986 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ALLYL CHLORIDE 000107-05-1
010369 BOQUIN. L. D SHUWEI. Y AIRU, ET AL. 1982 STUDIES ON THE TOXICITY OF ALLYL CHLORIDE ECOTOXICOL ENVIRON SAP 6 19-27
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL CHLORIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
ALUMINUM 007429-90-5
005162 US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR ALUMINUM PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
ALUMINUM PHOSPHIDE 020859-73-8
010255 HACKENBURG U 1972. CHRONIC INGESTION BY RATS OF STANDARD DIET TREATED WITH ALUMINUM PHOSPHIDE. TOXICOL APPL PHARMACOL 23(1) 147-158.
US EPA 1985 RfD/RfC WORK GROUP
AMETRYN 000834-12-8
005841 CIBA-GEIGY CORPORATION. 1961 CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 00034843 AVAILABLE FROM EPA WRITE TO FOI.
EPA. WASHINGTON. DC 20460
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMETRYN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
US EPA 1987 RfD/RfC WORK GROUP
AMINO-2-NAPHTHOL. 1- 002834-92-6
005842 US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR l-AMINO-2-NAPHTOL AND l-AMINO-2-NAPHTOL HYDROCHLORIDE PREPARED BY THE OFFICE
OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC.
AMINO-2-NAPHTOL HYDROCHLORIDE, 1- 001198-27-2
005843 US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR l-AMINO-2-NAPHTOL AND l-AMINO-2-NAPHTOL HYDROCHLORIDE PREPARED BY THE OFFICE
OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE.
WASHINGTON. DC
AMINOPHENOL, M- 000591-27-5
005844 RE TA. RF LOEHR. SC RODRIGUEZ, ET AL 1984. RESULTS OF TERATOGENICITY TESTING OF M-AMINOPHENOL IN SPRAGUE-DAWLEY RATS FUND APPL TOXICOL.
4(1) 98-104
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
AMINOPHENOL, 0- 000095-55-6
005845 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
AMINOPHENOL, P- 000123-30-8
005846 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
AMINOPYRIDINE, 4- 000504-24-5
005847 KOHN FE 1968. FOUR-WEEK SUBACUTE ORAL TOXICITY OF 1861 HYDROCHLORIDE -ALBINO RATS. (UNPUBLISHED STUDY) PREPARED BY INDUSTRIAL
BIOTEST LABORATORIES, INC. UNDER 224-12 SUBMITTED BY PHILLIPS PETROLEUM CO., BARTLESVILLE, OK CDL. 229844-E
US EPA 1980. 4-AMINQPYRIDINE. AVITRQL PESTICIDE REGISTRATION STANDARD PREPARED BY THE OFFICE OF PESTICIDE PROGRAMS. US EPA, WASHINGTON.
DC NTIS PB84-209907.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4-AMINOPYRIDINE. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
AMMONIA 007664-41-7
005166 CAMPBELL CL. RK DAWES. S OEOLALKAR AND MC MERRITT 1958 EFFECT OF CERTAIN CHEMICALS IN WATER ON THE FLAVOR OF BREWED COFFEE FOOD RES
23- 575-579. CITED IN US EPA, 1981,
WHO (WORLD HEALTH ORGANIZATION) 1985. ENVIRONMENTAL HEALTH CRITERIA 54. AMMONIA WHO, GENEVA. SWITZERLAND
US EPA. 1981. AMBIENT WATER QUALITY CRITERION FOR THE PROTECTION OF HUMAN HEALTH' AMMONIA PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS.
WASHINGTON, DC.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR AMMONIA. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
010392 HOLNESS DL. JT PURDHAM AND JR NETHERCQTT 1989. ACUTE AND CHRONIC RESPIRATORY EFFECTS OF OCCUPATIONAL EXPOSURE TO AMMONIA AMINO HYG
ASSOC J, 50- 646-650
BRODERSON JR. JR LINDSEY AND JE CRAWFORD, 1976 THE ROLE OF ENVIRONMENTAL AMMONIA IN RESPIRATORY MYCOPLASMOSIS OF RATS AM J PATHOL 85
115-130.
US EPA. 1991 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
ANILINE 000062-53-3
010370 OBERST FW. E HACKLEY, C COMSTOCK 1956. CHRONIC TOXICITY OF ANILINE VAPOR (5PPM) BY INHALATION. ARCH IND HEALTH 13:379-384
US EPA. 1985 HEALTH-AND ENVIRONMENTAL EFFECTS PROFILE FOR ANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA. 1990 RfD/RfC WORK GROUP.
ANTHRACENE 000120-12-7
010166 US EPA 1989. SUBCHRONIC TOXICITY IN MICE WITH ANTHRACENE FINAL REPORT. HAZELTON LABORATORIES AMERICA. INC PREPARED FOR THE OFFICE OF
SOLID WASTE. WASHINGTON. DC
US EPA 1991. DRINKING WATER CRITERIA DOCUMENT FOR ANTHRACENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC
US EPA. 1989. RfD/RfC WORK GROUP.
010964 US EPA. 1994. RfD/RfC WORK GROUP
ANTIMONY PENTOXIOE 001314-60-9
005174 SCHROEDER HA. M MITCHENER AND AP NASON 1970 ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES J NUTR 100 59-66.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
ANTIMONY POTASSIUM TARTRATE 000304-61-0
005234 SCHROEDER HA. M MITCHENER AND AP NASON. 1970 ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS LIFE-TIME STUDIES. J NUTR 100. 59-69.
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ANTIMONY TETROXIDE 001332-81-6
005238 SCHROEDER HA. M MITCHENER AND AP NASON 1970. ZIRCONIUM. NIOBIUM. ANTIMONY AND LEAD IN RATS LIFE-TIME STUDIES. J NUTR 100 59-69.
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
ANTIMONY TRIOXIDE 001309-64-4
005242 SCHROEDER HA. M MITCHENER AND AP NASON 1970. ZIRCONIUM. NIOBIUM, ANTIMONY AND LEAD IN RATS LIFE-TIME STUDIES J NUTR 100. 59-69
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
010974 NEWTON PE, HF BOLTS. IW DALY ET AL 1994 SUBCHRONIC AND CHRONIC INHALATION TOXICITY OF ANTIMONY TRIOXIDE IN THE RAT FUND APPL
TOXICOL 32 561-576
US EPA 1995 RfD/RfC WORK GROUP
ANTIMONY, METALLIC 007440-36-0
005170 SCHROEDER HA. M MITCHENER AND AP NASON 1970 ZIRCONIUM. NIOBIUM, ANTIMONY AND LEAD IN RATS' LIFE-TIME STUDIES. J NUTR 100' 59-66
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
*
ARAMITE 000140-57-8
005849 OSER BL. M OSER. 1962 2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE) II CARCINOGENICITY TOXICOL APPL PHARMACOL. 4:
70-88.
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ARAMITE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
005850 POPPER H. SS STERNBERG. BL OSER AND M OSER 1960. THE CARCINOGENIC EFFECT OF ARAMITE IN RATS CANCER 13(5). 1035-1046
OSER BL AND M OSER. 1962. 2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE). CARCINOGENICITY. TOXICOL APPL PHARMACOL. 4
70-88
US EPA. 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ARAMITE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
AROCLOR 1248 012672-29-6
010940 US EPA. 1993 RfD/RfC WORK GROUP.
AROCLOR 1254 011097-69-1
010963 US EPA 1994. RfD/RfC WORK GROUP.
ARSENIC. INORGANIC 007440-38-2
010434 TSENG WP 1977 EFFECTS AND DOSE-RESPONSE RELATIONSHIPS OF SKIN CANCER AND BLACKFOOT DISEASE WITH ARSENIC ENVIRON. HEALTH PERSPECT. 19
109-119.
TSENG. WP. HM CHU. SW HOU. JM FONG. CS LIN. S YEH 1968 PREVALENCE OF SKIN CANCER IN AN ENDEMIC AREA OF CHRONIC ARSENICISM IN TAIWAN J
NATL CANCER INST 40 453-463
US EPA 1990 RfD/RfC WORK GROUP.
ATRAZINE 001912-24-9
010855 CIBA-GEIGY CORP 1986 MRID NO 00141874. 00157875. 00158930. 40629302. HED DOC NO 005940. 006937. AVAILABLE FROM EPA WRITE TO FOI. EPA.
WASHINGTON. DC 20460
CIBA-GEIGY CORP. AGRICULTURAL DIVISION 1987 MRID NO 40431301. 41293801 HED DOC NO 006718. 006937. 007647 AVAILABLE FROM EPA WRITE TO
FOI. EPA. WASHINGTON, DC 20460
US EPA. 1992 RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCIN06ENICITY) July 1997
BARIUM 007440-39-3
WONES, R6, BL STAOLER, LA 1990, LACK OF EFFECT OF WATER ON CARDIOVASCULAR RISK FACTOR. HEALTH PERSPECT
85- 1-13.
BRENNIMAN, GR, PS LEVY 1984 HIGH BARIUM LEVELS IN PUBLIC DRINKING WATER AND ITS ASSOCIATION WITH ELEVATED BLOOD PRESSURE IN- ADVANCES
IN MODERN TOXICOLOGY IX. EJ CLALBRESE. ED. PRINCETON SCIENTIFIC PUBLICATIONS. PRINCETON. NJ P231-249
US EPA. 1985. DRINKING WATER CRITERIA DOCUMENT FOR BARIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON. DC. EXT REVIEW DRAFT. FINAL DRAFT (ON PUBLIC
COMMENT). NTIS PB 86-118031/AS.
US EPA 1990 RfD/RfC WORK GROUP
CYANIDE 000542-62-1
010941 US EPA. 1993 RfD/RfC WORK GROUP
BENEFIN 001861-40-1
005852 ELI LILLY AND CO 1972, CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO. 00037678 AVAILABLE FROM EPA. WRITE TO FOI. EPA,
WASHINGTON. DC 20460.
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENEFIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA 1985 RfD/RfC WORK GROUP
BENZAL CHLORIDE 000098-87-3
005853 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZAL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINMATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
BENZALDEHYDE 000100-52-7
005854 KLUWE WM, CA MONTGOMERY, HD GILES AND JD PREJEAU. 1983. ENCEPHALOPATHY IN RATS AND NEPHROPATHY IN RATS AND MICE AFTER SUBCHRONIC ORAL
EXPOSURE TO BENZALDEHYDE. FOOD CHEM TOXICOL. 21(3) 245-250.
US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1987 RfD/RfC WORK
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
BENZALDEHYDE CYANOHYDRIN 000532-28-5
005781 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
BENZO[A]ANTHRACENE 000056-55-3
010965 US EPA. 1994 RfD/RfC WORK GROUP
BENZENE 000071-43-2
010857 US EPA. 1989 RfD/RfC WORK GROUP.
BENZENETHIOL / (THIOPHENOL) 000108-98-5
010942 AMERICAN BIOGENICS CORP 1989. NINETY-DAY GAVAGE STUDY IN ALBINO RATS USING THIOPHENOL. PREPARED BY DYNAMAC CORP OF ROCKVILLE. MD FOR THE
US EPA OFFICE OF SOLID WASTE
FAIRCHILD EJ AND HE STOKINGER 1958 TOXICOLOGIC STUDIES ON ORGANIC SULFUR COMPOUNDS. 1 ACUTE TOXICITY OF SOME ALIPHATIC AND AROMATIC
THIOLS (MERCAPTANS) AM IND HYG ASSOC J. 19: 171-189.
US EPA 1993 RfD/RfC WORK GROUP
BENZIDINE 000092-87-5
005830 LITTLEFIELD NA. CJ NELSON AND CH FRITH. 1983 BENZIDINE DIHYDROCHLORIDE- TOXICOLOGICAL ASSESSMENTS IN MICE DURING CHRONIC EXPOSURE J
TOXICOL. ENVIRON. HEALTH. 12 671-685.
US EPA. 1987. RfD/RfC WORK GROUP
010877 US EPA. 1991. RfD/RfC WORK GROUP
BENZOIC ACID 000065-85-0
005260 FDA (FOOD AND DRUG ADMINISTRATION). 1973. EVALUATION OF THE HEALTH ASPECTS OF BENZOIC ACID AND SODIUM BENZOATE AS FOOD INGREDIENTS DHEW.
WASHINGTON. DC REPORT NO. SCOGS-7 NT1S PB-223 837/6 P 17
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BENZOIC ACID PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
US EPA 1987 RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
BENZYL ALCOHOL 000100-51-6
NTP (NATIONAL TOXICOLOGY PROGRAM). 1988 TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ALCOHOL (CAS NO 100-51-6) IN F344/NRATS AND
B6C3F1 MICE (GAVA6E STUDIES). NTP TECHNICAL REPORT. NTP TR 343. P 1-161.
005856 NTP (NATIONAL TOXICOLOGY PROGRAM) 1988. TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ALCOHOL (CAS NO 100-51-6) IN F344/NRATS AND
B6C3F1 MICE (GAVAGE STUDIES). NTP TECHNICAL REPORT. NTP TR 343. P 1-161.
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BENZYL ALCOHOL PREPARED 3Y THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
BERYLLIUM 007440-41-7
005262 SCHROEDER HA AND M MITCHNER 1975. LIFE-TERM STUDIES IN RATS: EFFECTS OF ALUMINUM, BARIUM, BERYLLIUM AND TUNGSTEN. J NUTR. 105: 421-427.
US EPA. 1991 DRINKING WATER CRITERIA DOCUMENT FOR BERYLLIUM PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON, DC.
US EPA. 1985. RfD/RfC WORK GROUP.
BIPHENYL, l.l1 000092-52-4
005857 AMBROSE AM. AN BOOTH, F DE EDS AND AJ COS JR. 1960. A TOXICOLOGICAL STUDY OF BIPHENYL. A CITRUS FUNGISTAT FOOD RES. 25. 328-336.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,1'-BIPHENYL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA. 1985. RfD/RfC WORK GROUP.
010878 US EPA 1990 RfD/RfC WORK GROUP.
BIS(2-CHLOROISOPROPYL) ETHER 039638-32-9
010257 MITSUMORI K, T USUI. K TAKAHASHI. AND Y SHIRASU. 1979 TWENTY-FOUR MONTH CHRONIC TOXICITY STUDIES OF DICHLORODIISOPROPYL ETHER IN MICE.
NIPPON NOYAKU GAKKAISHI 4(3) 323-335
US EPA. 1989 RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINQGENICITY) July 1997
BIS(2-ETHYLHEXYL) PHTHALATE / (DEHP) 000117-81-7
010859 CARPENTER, CP, CS WEIL AND HF SHYTH 1953 ORAL TOXICITY OF DK2-ETHYLHEXYL) PHTHALATE FOR RATS, GUINEA PIGS AND DOGS, ARCH IND
HYG OCC MED. 8: 219-226.
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI, OH FOR THE OFFICE OF WATER. WASHINGTON. DC.
US EPA 1986. RfO/RfC WORK GROUP.
BISPHENOL A 000080-05-7
005268 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF BISPHENOL A IN F344 RATS AND B6C3F1 MICE (FEED STUDY) NTP TECH REP
SER NO 80-35 NTIS PB 84-1555308 P 192,
US EPA 1988 RfD/RfC WORK GROUP.
005266 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982 CARCINOGENESIS BIOASSAY OF BISPHENOL A IN F344 RATS AND B6C3F1 MICE (FEED STUDY). NTP TECH REP
SER. NO 80-35 NTIS PB 84-1555308 P. 192
US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BISPHENOL A. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
BORON TRIFLUORIDE 007637-07-2
010395 RUSCH GM, GM HOFFMAN, RF NCCONNELL ET AL. 1986. INHALATION TOXICITY STUDIES WITH BORON TRIFLUORIDE. TOXICOL APPL PHARMACOL 83: 69-78.
US EPA 1991 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR AND BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
BORON, ELEMENTAL 007440-42-8
005272 WEIR RJ, JR AND RS FISHER 1972 TOXICOLOGIC STUDIES ON BORAX AND BORIC ACID TOXICOL APPL PHARMACOL 23(3) 351-364
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR BORON AMD COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC.
US EPA. 1989 RfD/RfC WORK GROUP
US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR BORON. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF WATER, WASHINGTON, DC
005269 GARABRANT DH. L BERNSTEIN. JM PETERS ET AL 1985. RESPIRATORY EFFECTS OF BORAX DUST BR J IND MED. 42: 831-837
US EPA. 1991 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
BROMINATED DIBENZO-P-DIOXINS
005858 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZO-P-DIOXINS PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON. DC.
US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZOFURANS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
BROMINATED DIBENZOFURANS
005859 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZOFURANS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC
BROMOACETONE 000598-31-2
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
BROMOCHLOROETHANES
005861 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOCHLOROETHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
BROMODICHLOROMETHANE 000075-27-4
005715 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICITY AND CARCINOGENICITY STUDIES OF BROMODICHLOROMETHANE IN F344/N RATS AND B6C3F1 MICE
(GAVAGE STUDIES). NTP TECH REPORT. SER NO 321, NIH PUB NO 87-2537
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1987. RfD/RfC WORK GROUP
BROMOETHENE / (VINYL BROMIDE) 000593-60-2
010929 BENYA TJ, WM BUSEY. MA DORATO AND PE BERTEAU 1982. INHALATION CARCINOGENICITY BIOASSAY OF VINYL BROMIDE IN RATS TOXICOL APPL PHARMACOL
64(3). 367-379.
BUSEY WM. 1979. ONCOGENIC POTENTIAL OF VINYL BROMIDE DURING CHRONIC INHALATION EXPOSURE -- RATS PATHOLOGY REPORT. EPA/OTS
8EHQ-0479-0281.
US EPA. 1993. RfD/RfC WORK GROUP
BROMOFORM 000075-25-2
005722 NTP (NATIONAL TOXICOLOGY PROGRAM) 1989. TOXICOLOGY AND CARCINOGENICITY STUDIES OF TRIBROMOMETHANE AND BROMOFORM IN F344 RATS AND B6C3F1
MICE (GAVAGE STUDIES) NTP-350
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA. 1987 HEALTH AND ENVIRONMENTAL ASSESSMENT FOR TRIHALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
DC
US EPA 1987 RfD/RfC WORK GROUP
010961 US EPA 1993. RfD/RfC WORK GROUP
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(OTHER THAN CARCINOGENICITY) July 1997
BROMOMETHANE 000074-83-9
010861 OANSE LH. FL VAN VELSEN AND CA VAN OER HEIJDEN 1984 METHYL BROMIDE: CARCINOGENIC EFFECTS IN THE RAT FORESTOMACH. TOXICOL APPL
PHARMACOL. 72: 262-271
US EPA, 1987 HEALTH EFFECTS ASSESSMENT FOR BROMOMETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC.
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL BROMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,' OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA 1988 RfD/RfC WORK
US EPA. 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR BROMOMETHANE PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON, DC
010860 REUZEL, PGJ, CF KUPER, HC DREEF-VAN DER MEULEN, VMH HOLLANDERS 1987 CHRONIC (29 MONTH) INHALATION TOXICITY AND CARCINOGEN1CITY STUDY OF
METHYL IN RATS, REPORT NO. V86.469/221044, NETHERLANDS ORGANIZATION FOR APPLIED SCIENTIFIC RESEARCH, DIVISION FOR NUTRITION AND
FOOD RESEARCH, TNO. EPA/OTS DOCUMENT 186-8700001202.
REUZEL, PGO, HC DREEF-VANDER MEULEN. VMH HOLLANDERS, CF KUPER, VJ FERON, CA VAN DER HEIJDEN 1991 CHRONIC INHALATION TOXICITY AND
CARCINOGENICITY STUDY OF METHYL BROMIDE IN WISTAR RATS. FOOD CHEM TOXICOL 29(1): 31-39.
US EPA 1991. RfD/RfC WORK GROUP.
BROMOPHENYL PHENYL ETHER, 4- 000101-55-3
005864 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-BROMOPHENYL PHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
BROMOPHOS 002104-96-3
005865 LEUSCHNER F. A LEUSCHNER AND E POPPE. 1967. CHRONISCHER REPRODUKTIONSVERSUCH UBER 3 GENERATIONEN AN WISTAR-RATTEN BEI FORTDAUERNER
VERABREICHUNG VON BROMOPHOS REPORT CH BOEHRINGER SOHN. (UNPUBLISHED).
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
BROMOXYNIL 001689-84-5
005866 UNION CARBIDE AGRICULTURE PRODUCTS, INC 1982 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO 00096521 AVAILABLE FROM
EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1987 RfD/RfC WORK GROUP
BROMOXYNIL OCTANOATE 001689-99-2
005867 UNION CARBIDE AGRICULTURE PRODUCTS. INC 1982 CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY MRID NO 00096521. AVAILABLE FROM
EPA WRITE TO FOI, EPA. WASHINGTON. DC 20460
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL OCTANOATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
US EPA 1987 RfD/RfC WORK GROUP
BUSAN 77 031512-74-0
005868 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 77 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
BUSAN 90 002491-38-5
005869 US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 90 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
BUTANOL. 1- 000071-36-3
005870 US EPA 1986 BUTANOL RAT ORAL SUBCHRONIC TOXICITY STUDY OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1-BUTANOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1986 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
BUTYL BENZYL PHTHALATE, N- 000085-68-7
005616 NTP (NATIONAL TOXICOLOGY PROGRAM) 1985. PROJECT NO 12307-02, -03 HAZELTON LABORATORIES AMERICA, INC, UNPUBLISHED STUDY
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS (PAE)S PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON, DC
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BUTYL BENZYL PHTHALATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
US EPA 1989 RfD/RfC WORK GROUP.
BUTYLATE 002008-41-5
005871 STAUFFER CHEMICAL COMPANY. 1987 CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO. 40289101 AVAILABLE FROM EPA WRITE TO
FOI. EPA, WASHINGTON. DC 20460
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUTYLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA. 1989 RfD/RfC WORK
BUTYLCHLORIDE, T- 000507-20-0
005810 US EPA. 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
BUTYROLACTONE, GAMMA- 000096-48-0
005872 US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUTYROLACTONE, GAMMA. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
CACODYLIC ACID 000075-60-5
005873 NEES PO 1968. REPORT ON CACODYLIC ACID TOXICITY TO ANIMALS WISCONSIN ALUMNI RES FOUND. EPA PESTICIDE PETITION NO OF 0911
US EPA. 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CACODYLIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
RMS
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
CADMIUM 007440-43-9
005280 US EPA 1985 DRINKING WATER CRITERIA DOCUMENT ON CADMIUM OFFICE OF DRINKING WATER. WASHINGTON, DC. FINAL DRAFT
US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CADMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON, DC.
EPA-440/5-80-025
US EPA 1988 RfD/RfC WORK GROUP.
CALCIUM CYANIDE 000592-01-8
010258 HOWARD JW AND RF HANZAL 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3' 325-329
PHILBRICK DJ. JB HOPKINS, DC HILL. JC ALEXANDER AND RG THOMSON 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS J
TOXICOL ENVIRON HEALTH 5 579-592
US EPA. 1985 RfD/RfC WORK GROUP
CAPROLACTAM 000105-60-2
005284 SEROTA DG, AM HOBERMAN AND SC GAD. 1984 A THREE-GENERATION REPRODUCTION STUDY WITH CAPROLACTAM IN RATS. IN: PROCEEDINGS OF A SYMPOSIUM
ON AN INDUSTRY APPROACH TO CHEMICAL RISK ASSESSMENT CAPROLACTAM AND RELATED COMPOUNDS AS A CASE STUDY INDUSTRY HEALTH FOUND ARLINGTON.
VA . P 191-204.
US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CAPROLACTAM PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1988 RfD/RfC WORK GROUP.
005282 POWERS WJ. JR. JC PECKHAM, KM SIINO AND SC GAD. 1984. EFFECTS OF SUBCHRONIC DIETARY CAPROLACTAM ON RENAL FUNCTION IN- PROCEEDINGS OF A
SYMPOSIUM ON AN INDUSTRY APPROACH TO CHEMICAL RISK ASSESSMENT- CAPROLACTAM AND RELATED COMPOUNDS AS A CASE STUDY INDUSTRY HEALTH FOUND.
ARLINGTON. VA
US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CAPROLACTAM PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
010966 US EPA 1994 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CAPTAFOL 002425-06-1
005874 ORTHO-CHEVRON CHEMICAL COMPANY 1985. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 260671, MRID NO. 00149488.
00155196 AVAILABLE FROM EPA. WRITE TO FOI, EPA, WASHINGTON. DC 20460
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAFOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
US EPA. 1987. RFD/RFC WORK GROUP
CAPTAN 000133-06-2
CHEVRON CHEMICAL COMPANY 1982 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY, MRID NO 00125293 AVAILABLE FROM EPA WRITE TO
FOI. EPA. WASHINGTON, DC 20460.
STAUFFER CHEMICAL COMPANY 1982 CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY MRID NO 00120315 AVAILABLE FROM EPA. WRITE TO
FOI. EPA. WASHINGTON, DC 20460.
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSHENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA. 1989. RfD/RfC WORK GROUP.
CARBARYL 000063-25-2
CARPENTER CP, CW WEIL, PE POLIN. ET AL 1961 MAMMALIAN TOXICITY OF 1-NAPHTHYL-N-METHYLCARBAMATE (SEVIN INSECTICIDE) J AGRIC FOOD CHEM.
9. 30-39
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBARYL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
US EPA 1985 RfD/RfC WORK GROUP.
010882 US EPA. 1991 RfD/RfC WORK GROUP
CARBOFURAN 001563-66-2
005877 FMC CORPORATION. 1983. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 250740-250755, MRID NO. 00129507. AVAILABLE
FROM EPA. WRITE TO FOI, EPA, WASHINGTON. DC 20460
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBOFURAN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA 1987 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CARBON DISULFIDE 000075-15-0
010259 HARD1N BO, GP BOND. MR SIKOR, FD ANDREW, RP BELILES AND RW NIEMEIR 1981. TESTING OF SELECTED WORKPLACE CHEMICALS FOR TERATOGENIC
POTENTIAL. SCAND J WORK ENVIRON HEALTH. 7(SUPPL 4) 66-75.
US EPA. 1985 RfD/RfC WORK GROUP
010975 JOHNSON BL, J BOYD. JR BURG ET AL. 1983. EFFECTS ON THE PERIPHERAL NERVOUS SYSTEM OF WORKERS' EXPOSURE TO CARBON DISULFIDE.
NEUROTOXICOLOGY 4 53-66.
US EPA 1995 RfD/RfC WORK GROUP.
CARBON MONOXIDE 000630-05-0
010493 REFER TO APPENDIX A: TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CARBON TETRACHLORIDE 000056-23-5
010862 BRUCKNER. JV, WF MACKENZIE. S MURALIDHARA, ET AL 1986 ORAL TOXICITY OF CARBON TETRACHLORIDE: ACUTE. SUBACUTE AND SUBCHRONIC STUDIES IN
RATS. FUND APPL TOXICOL. 6(1) 16-34.
US EPA. 1985 RfD/RfC WORK GROUP.
CHLORAL 000075-87-6
005290 SANDERS VM, BM KAUFFMANN, KL WHITE, JR. 1982 TOXICOLOGY OF CHLORAL HYDRATE IN THE MOUSE. ENVIRON HEALTH PERSPECT. 44. 146-173.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORAL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
US EPA. 1988 RfD/RfC WORK GROUP
CHLORDANE 000057-74-9
005296 VELSICOL CHEMICAL CORP. 1983. ACC NO 252267. MRID NO 00138591. 00144313. AVAILABLE FROM EPA. WRITE TO FOI. EPA, WASHINGTON, DC 20460.
US EPA. 1989 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CHLORINE CYANIDE 000506-77-4
010261 JW AND RF HANZAL 1955 TOXICITY FOR RATS OF FOOD TREATED WITH CYANIDE. AGRIC FOOD CHEH, 3- 325-329
PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS. J
TOXICOL ENVIRON HEALTH. 5: 579-592
US EPA. 1985 RfD/RfC WORK GROUP
CHLORO-1.3-BUTADIENE, 2- / (CHLOROPRENE) 000126-99-8
010515 NTP (NATIONAL TOXICOLOGY PROGRAM) 1988 SUBCHRONIC INHALATION TOXICITY STUDY OF CHLOROPRENE IN MICE AND RATS. CONDUCTED BY
BATELLE PACIFIC NORTHWEST LABORATORY. RICHLAND. WA.
US EPA. 1992. RfD/RfC WORK GROUP.
CHLORO-M-CRESOL, P- 000059-50-7
005366 MADSEN C, PH ANDERSEN, 0 MEYER AND G WURTZEN. 1986. 4-CHLQRQ-E-METHYLPHENOL: SALMQNELLA/MAMMALIAN-MICROSOME MUTAGENICITY TEST AND
SUBACUTE TOXICITY TEST IN RATS. BULL ENVIRON CONTAM TOXICOL. 37(5). 651-654
US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR P-CHLORO-H-CRESOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
CHLOROACETALDEHYDE 000107-20-0
005342 US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROACETALDEHYDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
CHLOROACETIC ACID 000079-11-8
IRDC (INTERNATIONAL RESEARCH AND DEVELOPMENT CORPORATION) 1982 ORAL TOXICITY TEST WITH MONOCHLOROACETIC ACID IN RATS
NATIONAL TOXICOLOGY PROGRAM, BETHESDA. MD P 1-101
US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROACETIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND RESPONSE.
WASHINGTON, DC.
CHLOROANILINE, 2- 000095-51-2
005347 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CHLOROANILINE, 3- 000108-42-9
005348 US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
CHLOROANILINE, 4- 000106-47-8
005349 NCI (NATIONAL CANCER INSTITUTE) 1979 BIOASSAY OF P-CHLOROANILINE FOR POSSIBLE CARCINOGENICITY NCI CARC TECH REP SER NO. 189 NTIS
PB-295896
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1987 RfD/RfC WORK GROUP
CHLOROBENZENE 000108-90-7
010863 MONSANTO COMPANY 1967 13-WEEK ORAL ADMINISTRATION-DOGS MONOCHLOROBENZENES FINAL REPORT PROJECT NO 241-105. FEBRUARY 24. PREPARED
BY HAZELTON LABORATORIES
KNAPP. WK, WM BUSEY. AND W KUNOZINS 1971 SUBACUTE ORAL TOXICITY OF MONOCHLOROBENZINE IN DOGS AND RATS TOXICOL APPL PHARMACOL. 19: 393
(ABSTRACT)
US EPA 1985 HEALTH ASSESSMENT DOCUMENT FOR CHLORINATED BENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH. EPA 600/8-84-015F NTIS PB85-150332.
US EPA. 1989 UPDATED HEALTH EFFECTS ASSESSMENT FOR CHOLOROBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1989 RfD/RfC WORK GROUP.
CHLOROBENZILATE 000510-15-6
010260 CIBA-GEIGY CORPORATION 1984 MRID NO 00144691 AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460.
US EPA 1991 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROBENZILATE PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE, OFFICE OF HEATH AND ENVIRONMENTAL ASSESSMENT, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
US EPA. 1989. RfD/RfC WORK GROUP
010931 US EPA 1993 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CHLOROBENZOIC ACID. P- 000074-11-3
005360 KIECKEBUSCH W. W GRIEM AND K LANG 1960 THE TOLERABILITY OF P-CHLOROBENZOIC ACID ARZNEIMI HEL-FORSCH 10 999-10001
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR P-CHLOROBENZOIC ACID PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
CHLOROBENZOTRIFLUORIDE, 4- 000098-56-6
005364 HOOKER CHEMICAL CORP. 1981 MODIFIED 90-DAY GAVAGE AND REPRODUCTION STUDY IN RATS PCBTF CONDUCTED BY ELARS BIORESEARCH LABORATORIES.
INC. FORT COLLINS. CO, US EPA/OPTS PUBLIC FILES MICROFICHE #OTS0508148
US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4-CHLOROBENZOTRIFLUORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
CHLOROBUTANE, 1- 000109-69-3
005808 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 TOXICOLOGY AND CARCINOGENESIS STUDIES OF N-BUTYL CHLORIDE IN F344/N RATS AND B6C3F1
MICE (GAVAGE STUDIES) CAS NO 109-69-3 NTP-TR-312. 198 P
US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
005806 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 TOXICOLOGY AND CARCINOGENESIS STUDIES OF N-BUTYL CHLORIDE IN F344/N RATS AND B6C3F1 MICE (GAVAGE
STUDIES). CAS NO 109-69-3. NTP-TR-312, 198 P
US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
CHLOROBUTANE, 2- 000078-86-4
005809 US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF.SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
CHLOROCYCLOPENTADIENE 041851-50-7
005297 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
July 1997
CHLOROFORM 000067-66-3
005372 US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTIDIENES PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
CHLOROMETHANE (METHYL CHLORIDE) 000074-87-3
010005 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
CHLORONITROBENZENE, M- 000121-73-3
005879 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
CHLOROPHENOL, 2-
010436 EXON JH.
LD KOELLER. 1982.
000095-57-8
EFFECTS OF TRANSPLACENTAL EXPOSURE TO CHLORINATED PHENOLS
ENVIRON HEALTH PERSPECT. 46: 137-140
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2.4-DICHLOROPHENOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
DC
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1990 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-CHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1988 RfD/RfC WORK GROUP.
CHLOROPHENOL, 3- 000108-43-0
005309 US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CHLOROPHENOL, 4- 000106-48-9
005310 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
CHLOROPROPANE, 2- 000075-29-6
010444 GAGE JC. 1970 THE SUBACUTE INHALATION TOXICITY OF 109 INDUSTRIAL CHEMICALS. BR J IND MED 27(1): 1-18.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-CHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
CHLOROTHALONIL 001897-45-6
005883 DIAMOND SHAMROCK CHEMICAL COMPANY. 1970. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY ACCESSION NO 111253. MRID NO 00057702.
00114034. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON, DC 20460.
US EPA, 1986. RfO/RfC WORK GROUP.
CHLOROTOLUENE, M- 000108-41-8
005880 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROTOLUENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
CHLOROTOLUENE, 0- 000095-49-8
010167 GIBSON. WR. FO GOSSETT, GR KOENIG. F MARROQUIN 1974 THE TOXICITY OF DAILY ORAL DOSES OF Q-CHLOROTOLUENE IN THE RAT. TOXICOLOGY
DIVISION. LILLY RESEARCH LABORATORIES SUBMITTED TO TEST RULES DEVELOPMENT BRANCH. OFFICE OF TOXIC SUBSTANCES, US EPA, WASHINGTON. DC
US EPA. 1989. RfD/RfC WORK GROUP.
CHLOROTOLUENE, P- 000106-43-4
010200 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHOROTOLUENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
CHLORPYRIFOS 002921-88-2
DOW CHEMICAL COMPANY 1972. CONFIDENTIAL BUSINESS INFORMATION. STUDY. ACCESSION NO 112118
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORPYRIFOS AND CHLOROPYRIFOS-METHYL. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC.
US EPA 1986. RfD/RfC WORK
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CHLORPYRIFOS METHYL 005598-13-0
005882 US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORPYRIFOS AND CHLORPYRIFOS-METHYL. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
CHLORTHIOPHOS 060238-56-4
005884 WORTHING CR AND SB WALKER, ED. 1983. THE PESTICIDE MANUAL. 7TH ED BRITISH CROP PROTECTION COUNCIL. THE LAVENHAM PRESS LTD SUFFOLK.
ENGLAND. P 130.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORTHIOPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
CHROMIUM(III) 016065-83-1
005731 IVANKOVIC S AND R PREUSSMAN 1975. ABSENCE OF TOXIC AND CARCINOGENIC EFFECTS AFTER ADMINISTRATIONS OF HIGH DOSES OF CHROMIC OXIDE PIGMENT
IN SUBACUTE AND LONG-TERM FEEDING EXPERIMENTS IN RATS FOOD COSMET TOXICOL. 13 347-351
US EPA. 1984 HEALTH EFFECTS ASSESSMENT FOR TRIVALENT CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1986 RfD/RfC WORK GROUP.
CHROMIUM(VI) 018540-29-9
005522 MACKENZIE RD. RU BYERRUM, CF DECKER ET AL. 1958. CHRONIC TOXICITY STUDIES. II. HEXAVALENT AND TRIVALENT CHROMIUM ADMINISTERED IN DRINKING
WATER TO RATS AM MED ASSOC ARCH IND HEALTH 18: 232-234.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXAVALENT CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA. 1986 RfD/RfC WORK GROUP.
CHRYSENE 000218-01-9
005885 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHRYSENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
COPPER 007440-50-8
005374 US EPA. 1987. DRINKING WATER CRITERIA DOCUMENT FOR COPPER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
COPPER CYANIDE 000544-92-3
010262 US EPA, 1986 90 DAY ORAL TOXICITY STUDY OF COPPER CYANIDE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA 1987 RfD/RfC WORK GROUP.
CRESOL. M- / (3-METHYLPHENOL) 000108-39-4
005380 US EPA 1986 O.M.P-CRESOL 90-DAY ORAL SUBCHRONIC TOXICITY STUDIES IN RATS. OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA. 1987. O.M.P-CRESOL. 90-DAY ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS OFFICE OF SOLID WASTE, WASHINGTON. DC.
US EPA 1987 RfD/RfC WORK GROUP
010888 US EPA 1991 RfD/RfC WORK GROUP
CRESOL, 0- / (2-METHYLPHENOL) 000095-48-7
005384 US EPA 1986. O.M.P-CRESOL. 90-DAY ORAL SUBCHRONIC TOXICITY STUDIES IN RATS. OFFICE OF SOLID WASTE. WASHINGTON, DC.
US EPA 1987. O.M.P-CRESOL 90-DAY ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS. OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA. 1987. RfD/RfC WORK GROUP.
010889 US EPA. 1991. RfD/RfC WORK GROUP.
CRESOL, P- / (4-METHYLPHENOL) 000106-44-5
010516 CMA (CHEMICAL MANUFACTURERS' ASSOCIATION). 1988 DEVELOPMENTAL TOXICITY EVALUATION OF 0-. M- OR P-CRESOL ADMINISTERED BY GAVAGE TO NEW
ZEALAND WHITE RABBITS. FINAL PROJECT REPORT 51-508. FICHE NO. OTS0517695
DEITZ D. AND LT MULLIGAN 1988. SUBCHRONIC TOXICITY OF P-CRESOL IN SPRAGUE-DAWLEY RATS. MBA CHEMICAL NO 25 PREPARED BY RESEARCH TRIANGLE
INSTITUTE. RESEARCH TRIANGLE PARK, NC. PREPARED FOR EPA. WASHINGTON, DC.
US EPA. 1993. RfD/RfC WORK GROUP.
010890 US EPA. 1991 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CUMENE 000098-82-8
005392 WOLF MA. VK ROWE. DD MCCOLLISTER. RL HOLLINGSWORTH AND F OYEN. 1956 TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND BENZENES AMA
ARCH IND HEALTH 14 387-398.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CUMENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
US EPA 1987 RfD/RfC WORK GROUP
005908 MONSANTO COMPANY. 1986 ONE MONTH STUDY OF CUMENE VAPOR ADMINISTERED TO MALE AND FEMALE SPRAGUE-DAWLEY RATS BY INHALATION US EPA/OTS
PUBLIC FILES. 8D SUBMISSION MICROFICHE* OTS 0513229
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CUMENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
CYANAZINE 021725-46-2
010411 El DU PONT DE NEMOURS AND COMPANY. INC 1986. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRID NO 40081901 AND 40229001
AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON. DC 20460
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYANAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1992. RfD/RfC WORK GROUP
US EPA 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR CYANAZINE PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER. WASHINGTON. DC.
CYANIDE 000057-12-5
005396 HOWARD JW AND RF HANZAL 1955 CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE J AGRIC FOOD CHEM. 3 325-329.
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR CYANIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA 1991. DRINKING WATER CRITERIA DOCUMENT FOR CYANIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC
US EPA 1985 RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CYANOGEN 000460-19-5
JW AND RF HANZAL 1955. TOXICITY FOR RATS OF FOOD TREATED WITH CYANIDE AGRIC FOOD CHEM 3 325-329.
US EPA. 1985. RfO/RfC WORK GROUP
CYANOGEN BROMIDE 000506-68-3
010264 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYOROGEM CYANIDE. AGRIC FOOD CHEM 3 325-329
US EPA. 1987 RfD/RfC WORK GROUP.
CYCLOATE 001134-23-2
005886 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
CYCLOHEXANOL 000108-93-0
005887 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOHEXANOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
CYCLOHEXYLAMINE 000108-91-8
005400 GAUNT IF. J HARDY. P GRASSO, SO GANGOLLI AND KR BUTTERWORTH. 1976. LONG-TERM TOXICITY OF CYCLOHEXYLAMINE HYDROCHLORIDE IN THE RAT FOOD
COSMET TOXICOL 14(4); 255-268.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA. 1987. RfD/RfC WORK GROUP.
GAUNT IF, M SHARRATT, PG GRASSO, AB AND SD GAN60LLI 1974. SHORT-TERM TOXICITY OF CYCLOHEXYLAMINE HCL IN THE RAT FOOD COSMET
TOXICOL 12- 609-624.
US EPA 1987, HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
CYCLOPENTADIENE 000542-92-7
010494 DOW. 1987 UNPUBLISHED DATA DOW CHEMICAL USA. MIDLAND. MI.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCIQPENTAOIENE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC
DACTHAL 001861-32-1
005888 ISK BIOTECH CORPORATION 1993 MRID NO 42731001, 42998401. HED DOC NO 010513. AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON. DC
20460
US EPA 1994 RfO/RfC WORK GROUP
DALAPON 000075-99-0
005889 PAYNTER 0, TW TUSING, 00 HCCOLLISTER AND VK ROWE. 1960 TOXICOLOGY OF DALAPON SODIUM (2.2-DICHLOROPROPIONIC ACID. SODIUM SALT). J AGRIC
FOOD CHEM. 8 47-51.
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DALAPON PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1988. RfO/RfC WORK GROUP
DDT 000050-29-3
LAUG. EP. AA NELSON. 06 FITZHUGH AND FM KUNZE. 1950. LIVER CELL ALTERATION AND DDT STORAGE IN THE FAT OF THE RAT INDUCED BY DIETARY
LEVELS OF 1-50 PPM DDT. J PHARMACOL EXP THERAP 98- 268-273
US EPA 1985 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DECABROHODIPHENYL ETHER 001163-19-5
005891 KOCIBA RJ. LO FRAUSON, CG HUMISTON, ET AL 1975. RESULTS OF A TWO-YEAR DIETARY FEEDING STUDY WITH DECABROMOOIPHENYL OXIDE (DCDPO) IN
RATS. COMBUST TOXICOL 2(4). 267-285
NORRIS JM, JW EHRMANTRAUT, CL GIBBONS, 11 AL. 1975 TOXICOLOGY OF OCTA6ROMQBIPHENYL AND DECABROHODIPHENYL OXIDE ENVIRON HEALTH PERSPECT
11.153461
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHER PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
US EPA 1985. RfD/RfC WORK GROUP.
DI-N-OCTYL PHTHALATE 000117-84-0
010275 PIEKACZ H 1971. EFFECT OF DIOCTYL AND OIBUTYL PHTHALATES ON THE ORGANISM OF RATS AFTER ORAL ADMINISTRATION IN PROLONGED EXPERIMENT II
SUBACUTE AND CHRONIC TOXICITY ROCZ PANSTW ZAKL HIG. 22(3): 295-307.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACID, ALKYL, ARYL, AND ALKYL/ARYL ESTERS. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE.
WASHINGTON. DC.
DIAZINON 000333-41-5
DAVIES 08 AND BJ HOLUB 1979 COMPARATIVE SUSCEPTIBILITY OF MALE AND FEMALE RATS TO DIETARY DIAZINON TOXICITY, J NUTR 109(6) XXVIII
DAVIES DB AND BJ HOLUB 1980. COMPARATIVE SUBACUTE TOXICITY OF DIETARY DIAZINON IN THE MALE AND FEMALE RAT TOXICOL APPL PHARMACOL
54(3): 359-367
DAVIES OB AND BJ HOLUB 1980 TOXICOLOGICAL EVALUATION OF DIETARY OIAZINON IN THE RAT ARCH ENVIRON CONTAM TOXICOL 9(6)- 637-650.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIAZINON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC
DIBENZOFURAN 000132-64-9
005409 US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR DIBENZOFURAN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
DIBROMOBENZENE, 1.4- 000106-37-6
005893 CARLSON GP AND RG TARDIFF 1977 EFFECT OF 1.4-OIBROMOBENZENE AND 1.2.4-TRIBROMOBENZENE ON1 XENOBIOTIC METABOLISM TOXICOL APPL PHARHACOL
42(1). 189-196
US EPA, 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA. 1986. RfD/RfC WORK GROUP
OIBROMOCHLOROMETHANE 000124-48-1
005894 NTP (NATIONAL TOXICOLOGY PROGRAM) 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORODIBROMOMETHANE IN F344/N RATS AND B6C3F1 MICE
(GAVAGE STUDIES) NTP TR282 NTIS P686-166675
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOCHLOROMETHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. OC.
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIBROMOCHLOROMETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA ANO ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
US EPA. 1987. RfD/RfC WORK GROUP
DIBROMOETHANE, 1,2- 000106-93-4
010854 RATCLIFFE JM, SM SCHRADER, K STEENLAND, DE CLAPP. T TURNER AND RW HORNUNG 1987. SEMEN QUALITY IN PAPAYA WORKERS WITH LONG-TERM EXPOSURE
TO ETHYLENE BROMIDE BR J IND MED 44- 317-326.
SCHRADER SM, TW TURNER AND JM RATCLIFFE. 1988 THE EFFECTS OF ETHYLENE BROMIDE ON SEMEN QUALITY A COMPARISON OF SHORT-TERM AND CHRONIC
EXPOSURE REPROD TOXICOLOGY 2* 191-198
US EPA 1992 RFD/RFC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DIBUTYL PHTHALATE 000084-74-2
005622 SMITH CC 1953. TOXICITY OF BUTYL STEARATE. DIBUTYL SEBACATE. DIBUTYL PHTHALATE AND METHOXYETHYL OLEATE ARCH HYG OCCUP MED. 7: 310-318.
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF MD REMEDIAL RESPONSE, WASHINGTON, DC.
US EPA 1991 DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS (PAE)S. PREPARED BY THE ENVIROHMEKTAL CRITERIA AND ASSESSMEHT
OFFICE. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, CINCINNATI. OH, FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.
US EPA. 1990. RfD/RfC WORK GROUP.
010892 US EPA. 1990. RfD/RfC WORK GROUP
DICAMBA 001918-00-9
010945 GQLDENTHAL, El, DC JESSUP AND DE RODWELL 1978 TERATOLOGY STUDY IN RABBITS: IRDC NO. 163-436 (UNPUBLISHED STUDY RECEIVED MARCH 6. 1979
UNDER 876-36 PREPARED BY INTERNATIONAL RESEARCH AND DEVELOPMENT CORP., SUBMITTED BY VELSICOL CHEMICAL CORP., CHICAGO. IL. CDL:237995-E)
CITED AS VELSICOL CHEMICAL (1978) IN U S EPA (1993). MRID AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC
20460
US EPA 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR DICAMBA. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON, DC
US EPA 1988 RfD/RfC WORK GROUP.
OICHLOROBENZENE, 1,2- 000095-50-1
010864 US EPA 1989 RfD/RfC WORK GROUP
DICHLOROBENZENE, 1.3- 000541-73-1
005414 US EPA 1987 HEALTH EFFECTS ASSESSHENT FOR DICHLQRQBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA. 1992. RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DICHLOROBENZENE, 1.4- 000106-46-7
010840 CHLOROBENZENE PRODUCERS ASSN 1986 PARADICHLOROBENZENE. TWO-GENERATION REPRODUCTION STUDY IN SPRAGUE-OAWLEY RATS STUDY N086-81-90605
MRID NO 411088-1 AVAILABLE FROM EPA. WRITE TO FOI, EPA. WASHINGTON. DC 20460.
NTP (NATIONAL TOXICOLOGY PROGRAM). 1987. TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.4-OICHLOROBENZENE IN F344/N RATS AND B6C3F1 MICE
(GAVAGE STUDIES). NTP TR 319. NIH PUBL NO 87-2575.
US EPA. 1992 RfD/RfC WORK GROUP.
DICHLOROBUTENES
005415 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DICHLOROBUTENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
DICHLORODIFLUOROMETHANE 000075-71-8
005498 SHERMAN H. 1974. LONG-TERM FEEDING STUDIES IN RATS AND DOGS WITH DICHLORODIFLUOROMETHANE (FREON 12 FOOD FREEZANT) HASKELL LABORATORY
REPORT NO 24-74. UNPUBLISHED. COURTESY DU PONT DE NEMOURS CO
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA. 1985 RfD/RfC WORK GROUP.
005496 CLAYTON WJ. JR. 1967 FLUOROCARBON TOXICITY AND BIOLOGICAL ACTION. FLUORINE CHEM REV 1(2). 197-252.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
DICHLOROETHANE, 1,1- 000075-34-3
005790 HOFMANN HT. H BIRNSTIEL AND P JOBST. 1971 ON THE INHALATION TOXICITY OF 1.1- AND 1,2-OICHLOROETHANE ARCH TOXIKOL 27 248-265.
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DICHLOROETHYLENE, 1,1- 000075-35-4
005419 QUASI JF, CG HUMISTQN, CE WADE. ET AL 1983. A CHRONIC TOXICITY AND ONCOGENICITY STUDY IN RATS AND SUBCHRONIC TOXICITY STUDY IN DOGS ON
INGESTED VINYLIDENE CHLORIDE FUND APPL TOXICOL. 3(1), 55-62
US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR 1,1-DICHLOROETHYLENE (VINYLIOINE CHLORIDE) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON. DC.
US EPA 1989 RfQ/RfC WORK GROUP.
DICHLOROETHYLENE, 1,2- (NIXED ISOMERS) 000540-59-0
010509 QUAST, JF, CG HUMISTON, CE WADE, ET AL. 1983. A CHRONIC TOXICITY AND ONCOGENICITY STUDY IN RATS AND SUBCHRONIC TOXICITY STUDY IN DOGS ON
INGESTED VINYLIDINE CHLORIDE FUND APPL TOXICOL. 3; 55-62
US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1,2-DICHLOROETHYLENE (MIXED ISOMERS). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC
DICHLOROETHYLENE, 1,2-C- 000156-59-2
005420 MCCAULEY PT. M ROBINSON, LW CONDIE, ET AL. NO DATE THE EFFECTS OF SUBACUTE AND SUBCHRONIC ORAL EXPOSURE TOCIS-1.2-DICHLOROETHYLENE IN
RATS HEALTH EFFECTS RESEARCH LABORATORY, US EPA. CINCINNATI, OH.
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR 1.2-C-DICHLOROETHYLENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA. 1990 RfD/RfC WORK GROUP
DICHLOROETHYLENE, 1,2-T- 000156-60-5
BARNES DW. WM SANDERS, KL SHITE JR. ET AL. 1985 TOXICOLOGY OF TRANS-1.2-DICHLOROETHYLENE IN THE MOUSE. DRUG CHEM TOXICOL 8 373-392
US EPA 1984. HEALTH EFFECTS ASSESSMENT FOR 1,2-T-OICHLOROETHYLENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC.
DICHLOROPHENOL, 2.3- 000576-24-9
005315 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIROHMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINQGENICITY) July 1997
DICHLOROPHENOL, 2,4- 000120-83-2
005314 EXQN JH, AND LD TOLLER- 1985. TOXICITY OF 2-CHLOROPHENOL.2.4-DICHLOROPHENOL AND 2,4.6-TRICHLOROPHENOL IN WATER CHLORINATION- CHEM,
ENVIRON IMPACT AND HEALTH EFF, JOLLEY ET AL, ED VOL. 5.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2.4-DICHLOROPHENOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON.
DC
US EPA 1986, RfD/RfC WORK GROUP.
DICHLOROPHENOL, 2,5- 000583-78-8
005316 US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
DICHLOROPHENOL, 2,6- 000087-65-0
005317 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
US EPA 1988 RfD/RfC WORK GROUP
DICHLOROPHENOL, 3,4- 000095-77-2
005318 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
DICHLOROPHENOL, 3,5- 000591-35-5
005319 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
DICHLOROPHENOXY ACETIC ACID, 2,4- 000094-75-7
010265 DOW CHEMICAL CO 1983 ACC NO 251473
US EPA 1988 RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DICHLOROPHENOXY) BUTYRIC ACID, 4-(2,4- / (2,4-DB) 000094-82-6
005890 RHODIA INC 1969 CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRIO NO 0092165 AVAILABLE FROM EPA WRITE TO FOI. EPA.
WASHINGTON. DC 20460.
US EPA, 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR- 2,4-DB. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
DICHLOROPROPANE. 1,1- 000078-99-9
005897 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
DICHLOROPROPANE, 1,2- 000078-87-5
005898 NITSCHKE KD. KA JOHNSON. DL WACKERLE. JE PHILLIPS, DA DITTENBER 1988 PROPYLENE DICHLORIDE. A 13 WEEK INHALATION TOXICITY STUDY WITH
RATS, MICE AND RABBITS DOW CHEMICAL CO, MAMMALIAN AND ENVIRONMENTAL TOXICOLOGY RESEARCH LABORATORY, MIDLAND, MI.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
US EPA. 1991. RfO/RfC WORK GROUP
DICHLOROPROPANE, 1,3- 000142-28-9
005899 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
DICHLOROPROPANE, 2,2- 000594-20-7
005900 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DICHLOROPROPENE, 1.3- / (TELONE II) 000542-75-6
005901 DOW CHEMICAL CO 1973. MRID NOS 00067977. 0039684 AVAILABLE FROM EPA WRITE TO FOI, EPA, WASHINGTON. DC 20460.
US EPA. 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1,3-DICHLOROPROPENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA 1987. RfD/RfC WORK GROUP.
US EPA 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR 1.3-DICHLOROPROPENE. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER, WASHINGTON.
DC
010351 LOMAX. LG. WT STOTT. KA JOHNSON, ET AL. 1989. THE CHRONIC TOXICITY AND ONCOGENICITY OF INHALED TECHNICAL-GRADE 1.3-DICHLOROPROPENE IN
RATS AND MICE. FUND APPL TOXICOL 10- 214.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3-DICHLOROPROPENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1990. RfD/RfC WORK GROUP.
DICHLORPROP 000120-36-5
005896 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROP PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
DICYCLOPENTADIENE 000077-73-6
005425 LITTON BIONETICS. INC 1980 MAMMALIAN TOXICOLOGICAL EVALUATION OF DIMP AND DCPD. (PHASE 2) LITTON BIONETICS. INC . KENSINGTON, MD
CONTRACT DAMB. 17-77-C-7003. NT1S AD-A082685.
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC
DIELDRIN 000060-57-1
005429 WALKER AIT. DE STEVENSON. J ROBINSON. ET AL 1969 THE TOXICOLOGY AND PHARMACODYNAMICS OF DIELDRIN (HEOD). TWO-YEAR ORAL EXPOSURE OF RATS
AND DOGS TOXICOL APPL PHARMACOL 15 345-373
US EPA. 1987. RfD/RfC WORK GROUP
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(OTHER THAN CARCINOGENICITY) July 1997
DIETHYL PHTHALATE 000084-66-2
005620 BROWN 0. KR BUTTERWORTH, IF GAUNT ET AL 1978 SHORT-TERMORAL TOXICITY STUDY OF DIETHYL PHTHALATE IN THE RAT FOOD COSMET TOXICOL 16.
415-422.
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC.
U S. EPA. 1991 DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS (PAE)S PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE, OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH, FOR THE OFFICE OF DRINKING WATER, WASHINGTON, DC
US EPA 1987 RfD/RfC WORK
DIETHYL-P-NITROPHENYL PHOSPHATE 000311-45-5
005922 US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIETHYL-P-NITROPHENYL PHOSPHATE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC,
DIETHYLANILINE, N,N- 000091-66-7
005903 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIETHYLANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
DIETHYLENE QLYCOL MONOBUTYL ETHER 000112-34-5
00548? US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC EPA 540/1-86-052
US EPA 1992. RfD/RfC WORK GROUP
DIETHYLENE GLYCOL MONOETHYL ETHER 000111-90-0
005478 SMYTH HE. CP CARPENTER AND CB SHAFFER. 1964 A 2-YEAR STUDY OF DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS FOOD COSMET TOXICOL 2
641-642
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC EPA 540/1-86-052.
005476 HALL DE. FS LEE. P AUSTIN AND FA FAIRWEATHER 1966 SHORT-TERM FEEDING STUDY WITH DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS FOOD COSMET
TOXICOL 4 263
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSHENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC EPA 540/1-86-052
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(OTHER THAN CARCINOGENICITY) July 1997
DIETHYLFORMAMIDE 000617-84-5
010437 MF, JC ARCOS AND C HOCH-LIGETI 1965. THE CARCINOGENIC ACTIVITY OF PROTEIN-DENATURING AGENTS: HEPATOCARCINOGENICITY OF DIGXANE. J.
NATL CANCER INST 35. 949-958.
US EPA, 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIETHYLFORMAMIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
DIETHYLHYDRAZINE. 1.2- 001615-80-1
005921 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2-DIETHYLHYDRAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
DIHETHOATE 000060-51-5
005923 AMERICAN CYANAMIO COMPANY 1986 MRID NO 00164177 AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON. DC 20460
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHOATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA 1988 RfD/RfC WORK GROUP
DIHETHYUNILINE, N,N- 000121-69-7
005924 ABDO K, M WOLFE AND R HILES, 1984 SUBCHRONIC TOXICITY OF N.N-DIMETHYLANILINE TO F-344 RATS AND B6C3F1 MICE. FED PROC, 43(3)- 1698
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-OIMETHYLANILINE. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) July 1997
DIMETHYLFORMAMIDE. N.N- 000068-12-2
005925 BECCI. PJ. KA VOSS, WD JOHNSON. ET AL 1983 SUBCHRONIC FEEDING STUDY OF N.N-DIMETHYLFORMAMIDE IN RATS AND MICE J AM COLL TOXICOL. 2(6):
371-378-
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLFORMAMIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH, FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
010352 CIRLA. AM. G PISATI. E INVERNIZZI ET AL 1984. EPIDEMIOLOGICAL STUDY ON WORKERS EXPOSED TO LOW DIMETHYLFORMAMIDE CONCENTRATIONS- G ITAL
MED LAV 6 149-156.
CATENACCI. G. D GRAMPELLA, R TERZI, ET AL 1984 HEPATIC FUNCTION IN SUBJECTS EXPOSED TO ENVIRONMENTAL CONCENTRATIONS OF DMF LOWER THAN
THE ACTUALLY PROPOSED TLV 6 ITAL MED LAV 6. 157-158.
US EPA 1990 RfO/RfC WORK GROUP.
DIMETHYLPHENQL, 2,3- 000526-75-0
005926 US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
DIMETHYLPHENOL, 2,4- 000105-67-9
010266 US EPA. 1989 NINETY-DAY STUDY IN ALBINO MICE USING 2,4-DIMETHYLPHENOL STUDY 410-2831. PREPARED BY DYNAMAC CORPORATION,
ROCKVIILE, MD. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
US EPA 1990 RfD/RfC WORK GROUP.
DIMETHYLPHENOL, 2,5- 000095-87-4
005928 US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC,
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(OTHER THAN CARCINOGENICITY) July 1997
DIMETHYLPHENOL, 2,6- 000576-26-1
005431 VELDRE IA AND HJ JANES 1979 TOXICOLOGICAL STUDIES OF SHALE OILS, SOME OF THEIR COMPONENTS AND COMMERCIAL PRODUCTS ENVIRON HEALTH
PERSPECT. 30. 141-146
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSHENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
DIMETHYLPHENOL, 3,4- 000095-65-8
005437 VELDRE IA AND HJ JANES 1979, TOXICOLOGICAL STUDIES OF SHALE OILS, SOME OF THEIR COMPONENTS AND COMMERCIAL PRODUCTS ENVIRON HEALTH
PERSPECT. 30. 141-146
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA. 1985 RfO/RfC WORK GROUP
DIHETHYLPHTHALATE 000131-11-3
010267 US EPA 1994. RfD/RfC WORK GROUP.
010894 US EPA 1990. RfD/RfC WORK GROUP
DIMETHYLTEREPHTHALATE 000120-61-6
005930 NCI (NATIONAL CANCER INSTITUTE) 1979. BIOASSAY OF DIMETHYL TEREPHTHALATE FOR POSSIBLE CARCINOGENICITY DHEW/PUB/NIH 79-1376.
NCI-CG-TR121
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYL AND METHYL TEREPHTHALATE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC
DIHETHYLUREA, N,N- 000598-94-7
005931 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLUREA PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
DINITRO-0-CRESOL, 4,6- 000534-52-1
010470 US EPA, 1993 RfD/RfC WORK GROUP
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROCRESOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DIN1TRO-P-CRESOL. 2,6- 000609-93-8
005934 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,6-DINITRO-P-CRESQL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
OINITROBENZENE, 1.2- 000528-29-0
010201 CODY TE, S WITHERUP. L HASTINGS, K STEMHER AND RT CHRISTIAN 1981 1,3-DINITROBENZENE. TOXIC EFFECT IN VIVO AND IN VITRO J TOXICOL
ENVIRON HEALTH 7(5): 829-847.
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROBENZENES (0-, M-. P-) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC
DINITROBENZENE, 1,3- 000099-65-0
010471 CODY TE, S WITHERUP, L HASTINGS. K STEMMER AND RT CHRISTIAN. 1981 1.3-DINITROBENZENE. TOXIC EFFECT IN VIVO AND IN VITRO J TOXICOL
ENVIRON HEALTH 7(5). 829-847.
US EPA. RfD/RfC WORK GROUP
DINITROBENZENE, 1.4- 000100-25-4
010202 CODY TE. S WITHERUP, L HASTINGS, K STEMMER AND RT CHRISTIAN 1981, 1,3-DINITROBENZENE' TOXIC EFFECT IN VIVO AND IN VITRO J TOXICOL
ENVIRON HEALTH 7(5): 829-847.
US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROBENZENES (0-, M-, P-) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSHENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
DINITROPHENOL, 2,3- 000066-56-8
005936 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DINITROPHENOL, 2,4- 000051-28-5
010438 WD. 1942 DINITROPHENOL AND ITS RELATION TO FORMATION OF CATARACTS. ARCH OPHTHALMOL 27 1097-1121.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPBENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.
US EPA 1991 RfD/RfC WORK GROUP
010895 US EPA. 1991 RfD/RfC WORK GROUP
DINITROPHENOL, 2.5- 000329-71-5
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED). BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
DINITROPHENOL, 2,6- 000573-56-8
005938 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
DINITROPHENOL, 3.5- 000586-11-8
005939 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA ANO ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
DINITROTOLUENE, 2,3- 000602-01-7
005940 US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
DINITROTOLUENE. 2,4 000121-14-2
005941 ELLIS HV. CB HONG. CC LEE. ET AL 1985 SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF 2,4-DINITROTOLUENE PART I BEAGLE DOGS J AM COLLEGE
TOXICOL. 4(4) 233-242
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA 1991 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
DINITROTQLUENE, 2,4- 000121-14-2
010896 US EPA. 1990 RfC WORK GROUP.
DINITROTOLUENE, 2,5- 000619-15-8
005942 US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
DINITROTOLUENE, 2,6- 000606-20-2
005943 LEE C-C ET AL 1976 MAMMALIAN TOXICITY OF MUNITIONS COMPOUNDS PHASE II EFFECTS OF MULTIPLE DOSES PART III 2.6-DITINROTOLUENE US
ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND, FORT DETRICK, MD
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1991 RfO/RfC WORK GROUP
DINITROTOLUENE, 3,4- 000610-39-9
005944 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
DINOSEB 000088-85-7
DOW CHEMICAL COMPANY. 1981. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY MRID NO 00152675. AVAILABLE FROH EPA WRITE TO FOI,
EPA. WASHINGTON, DC 20460
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINOSEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
US EPA 1986 RfD/RfC WORK GROUP.
DIPHENYLAMINE, N,N- 000122-39-4
005946 THOMAS JO. WE RIBELIN. JR WOODWARD AND F DEEDS 1967 THE CHRONIC TOXICITY OF DIPHENYLAMINE FOR DOGS TOXICOL APPL PHARMACOL. 11.
184-194
US EPA 1985 HEALTH AND EFFECTS PROFILE FOR N.N-DIPHENYLAMINE BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1986. RfO/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DIRECT LIGHTFAST BLUE 004399-55-7
005947 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT LIGHTFAST BLUE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
DISULFOTON 000298-04-4
010412 MOBAY CHEMICAL COMPANY. 1985 MRID NO. AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460.
US EPA. 1990 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DISULFOTON PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC
US EPA. 1986. RfD/RfC WORK GROUP.
ENDOSULFAN 000115-29-7
010926 HOECHST CELANESE CORP 1989. ENDOSULFAN 2-YEAR FEEDING/ONCOGENICITY STUDY IN RATS MRID NO 40256502. 42099502 HED DOC NO 007937
AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460
US EPA 1993. RfD/RfC WORK GROUP.
010938 HOECHST CELANESE CORP 1989 ENDOSULFAN- 1-YEAR FEEDING STUDY IN DOGS. MRID. NO 41099501 HED NO 007937. AVAILABLE FROM EPA WRITE TO
FOI. EPA. WASHINGTON. DC 20460
US EPA 1993 RfD/RfC WORK GROUP
ENDOTHALL 000145-73-3
005948 PENNWALT AGCHEM ND MRID NO 00101735 AVAILABLE FROM US EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ENDOTHALL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
ENDRIN 000072-20-8
005445 VELSICOL CHEMICAL CORPORATION 1969. MRID NO 00030198 AVAILABLE FROM EPA WRITE FOI. EPA. WASHINGTON. DC 20460.
- US EPA 1991 DRINKING WATER CRITERIA DOCUMENT FOR ENDRIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR ENDRIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1988 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
EPICHLOROHYDRIN 000106-89-8
010440 LASKIN S. AR SELLAKUMAR. M KUSCHNER. ET AL 1980. INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN NON-INBRED SPRAGUE-DAWLEY RATS. J NATL
CANCER INST. 65(4): 751-757.
US EPA 1984. HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYORIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC EPA 600/8-83-032F NTIS PB85-132363
US EPA 1991 RfD/RfC WORK GROUP.
010492 QUAST JF, JW HENCK, BJ POSTHA, OJ SCHUETZ AND MJ MCKENNA 1979 EPICHLOROHYDRIN - SUBCHRONIC STUDIES I A 90-DAY INHALATION STUDY IN
LABORATORY RODENTS (FISCHER 344 RATS, SPRAGUE-DAWLEY RATS AND B6C3F1 MICE). DOW CHEMICAL USA, MIDLAND. MI
US EPA 1991 RfD/RfC WORK GROUP
EPTC 000759-94-4
005959 PPG INDUSTRIES, INC. 1986 CONFIDENTIAL BUSINESS INFORMATION: UNPUBLISHED STUDY ACCESSION NO 263695, 262696, MRID NO. 00161597
AVAILABLE FROM EPA WRITE FOI, EPA, WASHINGTON, DC 20460,
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPTC PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
ETHOPROP 013194-48-4
005951 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHOPROP PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
ETHOXYETHANOL ACETATE, 2- 000111-15-9
010507 UNION CARBIDE 1984 A TERATOGENIC EVALUATION OF CELLOSOLVE ACETATE IN FISHER 344 RATS AND NEW ZEALAND WHITE RABBITS FOLLOWING INHALATION
EXPOSURE BUSHY RUN RESEARCH CENTER, EXPORT. PA, OCTOBER 1984 FYI-AX-1184-0360
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
ETHOXYETHANOL ACRYLATE, 2- 000106-74-1
005953 US EPA 1985, HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ETHOXYETHANOL DODECANOATE. 2- 000106-13-8
005956 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
ETHOXYETHANOL PHOSPHATE. 2- 068554-00-7
005955 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
ETHOXYETHANOL, 2- 000110-80-5
005470 MELNICK RL 1984 TOXICITIES OF ETHYLENE GLYCOL AND ETHYLENE GLYCOL MONOETHYL ETHER IN FISCHER 344/N RATS AND B6C3F1 MICE ENVIRON HEALTH
PERSPECT 57 147-155
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXY-ETHANOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
005468 STENGER EG. A LISLOTT. D MUELLER ET AL ' 1971 TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYL ETHER ARZNEIM-FORSCH. 21(6)- 880-885
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC EPA 540/1-86-052
010441 BARBEE SJ. JB TERRILL. DJ DESOUSA AND CC CONAWAY 1984 SUBCHRONIC INHALATION TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYL ETHER IN THE RAT
AND RABBIT. ENVIRON HEALTH PERSPECT 57 157-163
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC EPA 540/1-86-052
US EPA 1990 RfD/RfC WORK GROUP
ETHOXYETHYL METHACRYLATE, 2- 002370-63-0
005954 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXYETHANOL ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ETHYL ACETATE 000141-78-6
005957 US EPA 1986. RAT ORAL SUBCHRONIC STUDY WITH ETHYL ACETATE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA, 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL ACETATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
US EPA. 1986 RfD/RfC WORK GROUP.
ETHYL BENZENE 000100-41-4
010867 WOLF MA, VK ROME, DO MCCOLLISTER, RL HQLLINGSWQRTH AND F OYEN. 1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND BENZENES. AMA
ARCH IND HEALTH 14 387-398 CITED IN US EPA, 1985
US EPA. 1934, HEALTH EFFECTS ASSESSMENT FOR ETHYLBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYLBENZENE PREPARED 8Y THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
US EPA. 1985 RfD/RfC WORK GROUP
010866 ANDREW FO. RL BUSHCOHBOM. WC CANNON. ET AL 1981 TERATOLOGIC ASSESSMENT OF ETHYLBENZENE AND 2-ETHQXYETHANOL BATTELLE PACIFIC NORTHWEST
LABORATORY. RICHLANO. WA NTIS PB83-2Q8074 P 108.
HARDIN BO. GP BONO, MR SIKOV, ET AL 1981 TESTING OF SELECTED WORKPLACE CHEMICALS FOR TERATOGENIC POTENTIAL SCANDJ WORK ENVIRON HEALTH.
7 66-75
US EPA. 1990. RfD/RfC WORK GROUP
ETHYL CHLORIDE 000075-00-3
010371 SCORTICHINI BH. KA JOHNSON. JJ MQMANY-PFRUENDER ET AL 1986 ETHYL CHLORIDE. INHALATION TERATOLOGY STUDY IN CF-1 MICE DOW CHEMICAL CO
EPA 86-870002248
US EPA 1990 RfD/RfC WORK GROUP
ETHYL 000060-29-7
010396 AMERICAN BIOGENICS CORP 1986 90-DAY GAVAGE STUDY IN RATS USING ETHYL ETHER STATUS REPORT FOR ABC STUDY NO 410-23433/18/86.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYL ETHER ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH. OFFICE OF SOLID
WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA, 1989 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ETHYL METHACRYLATE 000097-63-2
005961 BORZELLECA JF, PS LARSON. GR HENNIGAR, ET AL. 1964 STUDIES ON THE CHRONIC ORAL TOXICITY OF MONOMERIC ETHYL ACRYLATE AND METHYL
METHACRYLATE TOXICOL APPL PHARMACOL. 6- 29-36
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL METHACRYLATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
ETHYL-0-XYLENE. 4- 000934-80-5
010472 US EPA. 1984. HEALTH AND ENVIRONMENTAL PROFILE FOR METHYLETHYL BENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
ETHYLANILINE, N- 000103-69-5
005958 US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N-ETHYLANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
ETHYLENE CYANOHYDRIN 000109-78-4
005780 SAUERHOFF MW. WH BRAUN. JC RAMSEY ET AL. 1976 TOXICOLOGICAL EVALUATION AND PHARMACOKINETIC PROFILE OF B-HYDROXYPROPIONITRILE IN RATS J
TOXICOL ENVIRON HEALTH 2(1) 31-44
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
ETHYLENE DIAMINE 000107-15-3
005796 YANG RS. RH GARMAN. RR MARONPOT. ET AL 1983. ACUTE AND SUBCHRONIC TOXICITY OF ETHYLENEDIAMINE IN LABORATORY ANIMALS APPL TOXICOL 3(6)
512-520.
US EPA. 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ETHYLENEDIAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
010898 US EPA 1990 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ETHYLENE GLYCOL 000107-21-1
DEPASS LR, RH CARMAN, MD WOODSIDE ET AL 1986. CHRONIC TOXICITY AND ONCOGENICITY STUDIES OF ETHYLENE GLYCOL IN RATS AND MICE FUND APPL
TOXICOL, 7. 547-565.
US EPA 1987 RfD/RfC WORK GROUP.
005452 MAROMPOT RR. JP ZELENAK, EV WEAVER AND NJ SMITH 1983. TERATOGENICITY STUDY OF ETHYLENE GLYCOL IN RATS DRUG CHEM TOXICOL 6(6) 579-594.
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE GLYCOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
ETHYLENE GLYCOL MONOBUTYL ETHER 000111-76-2
010353 OOOD DE, WM SWELLINGS, RR MAROMPOT, ET AL 1983 ETHYLENE GLYCOL MONOBUTYL ETHER ACUTE. 9-DAY AND 90-DAY VAPOR INHALATION STUDIES IN
FISCHER 344 RATS. TOXICOL APPL PHARMACOL. 68 405-414.
US EPA. 1991 RfD/RfC WORK GROUP
ETHYLENE THIOUREA 000096-45-7
010397 GRAHAM SL. KJ DAVIS. WH HANSEN AND CH GRAHAM. 1975. EFFECTS OF PROLONGED ETHYLENE THIOUREA INGESTION ON THE THYROID OF THE RAT fOOD
COSMET TOXICOL 13: 493-499
US EPA 1991 RfD/RfC WORK GROUP
010899 US EPA 1992 RfD/RfC WORK GROUP
ETHYLTOLUENE, M- 000620-14-4
005963 US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ETHYL BENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
ETHYLTOLUENE, 0- 000611-14-3
005962 US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ETHYL BENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
ETHYLTOLUENE, P- 000622-96-8
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ETHYL BENZENE- BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
. (OTHER THAN CARCINOGEN1CITY) July 1997
FLUORANTHENE 000206-44-0
010168 US EPA. 1988 13-WEEK MOUSE ORAL SUBCHRONIC TOXICITY STUDY PREPARED BY TOXICITY RESEARCH LABORATORIES. LTD, MUSKE60N, MI FOR THE OFFICE
OF SOLID WASTE, WASHINGTON. DC.
US EPA. 1989. RfD/RfC WORK GROUP.
010967 US EPA. 1994. RfD/RfC WORK GROUP.
FLUORENE 000086-73-7
010169 US EPA 1989. MOUSE ORAL SUBCHRONIC STUDY PREPARED BY TOXICITY RESEARCH LABORATORIES, LTD, MUSKEGON, MI. FOR THE OFFICE OF SOLID WASTE,
WASHINGTON, DC
US EPA 1991 DRINKING WATER CRITERIA DOCUMENT FOR FLUORENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON, DC
US EPA 1989 RfD/RfC WORK GROUP
FLUORINE / (SOLUBLE FLUORIDE) 007782-41-4
005965 HODGE HC 1950 THE CONCENTRATION OF FLUORIDES IN DRINKING WATER TO GIVE THE POINT OF MINIMUM CARIES WITH MAXIMUM SAFETY J AM DENT
ASSOC 40- 436
US EPA. 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR FLUORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA. 1986 RfD/RfC WORK
FLURIDONE 059756-60-4
005966 ELANCO PRODUCTS COMPANY. DIVISION OF ELI LILLY AND COMPANY 1980 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY ACCESSION NOS
070933, 070939 MRID NO 00103251, 00103305 AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON, DC 20460.
US EPA, 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FLURIDONE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE AND EMERGENCY RESPONSE.
WASHINGTON, DC
US EPA 1988, RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
FOLPET 000133-07-3
005967 CHEVRON CHEMICAL CORPORATION 1986 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY ACCESSION NO 263772 MRID NO 00161315.
AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON. DC 20460.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FOLPET. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
uS EPA. 1987 RFD/RFC WORK GROUP.
FORMALDEHYDE 000050-00-0
010398 TIL HP. RA WOUTERSEN, VJ FERON ET AL 1989. TWO-YEAR DRINKING WATER STUDY OF FORMALDEHYDE IN RATS FOOD CHEM TOXICOL 27 77-87
US EPA. 1989. DRAFT DRINKING WATER HEALTH ADVISORY FOR FORMALDEHYDE OFFICE OF DRINKING WATER, WASHINGTON, DC
US EPA. 1990 RfD/RfC WORK GROUP.
FORMALDEHYDE CYANOHYDRIN 000107-16-4
005782 US EPA. 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
FORMIC ACID 000064-18-6
010268 MALORNY G. 1969 ACUTE AND CHRONIC TOXICITY OF FORMIC ACID AND FORMATE. Z ERNACHRUNGSWISS. 9. 332-339
US EPA. 1990 RfD/RfC WORK GROUP
FURAN 000110-00-9
005462 SRI (SOUTHERN RESEARCH INSTITUTE) 1982 SUBCHRONIC TOXICITY REPORT ON FURAN (C56202) IN B6C3F1 MICE PREPARED FOR NATIONAL TOXICOLOGY
PROGRAM UNDER CONTRACT NO l-CP-95641-01. BETHESDA. MD.
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR FURAN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1986 RfD/RfC WORK GROUP
FURFURAL 000098-01-1
005466 SRI (SOUTHERN RESEARCH INSTITUTE) 1981 90 DAY RAT REPORT. UNPUBLISHED STUDY PERFORMED FOR NTP.
US EPA. 1987. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXIC1TY
(OTHER THAN CARCINOGENICITY) July 1997
GLYCIDALDEHYDE 000765-34-4
005968 HINE CH. RJ GUZMAN. MK DUNLAP, R LIMA AND GS LOQUVAM. 1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE ARCH ENVIRON HEALTH 2: 23-30
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR GLYCIDALDEHYDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA 1987 RfD/RfC WORK GROUP
HEPTACHLOR 000076-44-8
005506 VELSICOL CHEMICAL CORP 1955 MRID NO 00062599. AVAILABLE FROM EPA. WRITE TO FOI. EPA. WASHINGTON. DC 20460
US EPA. 1987. RfD/RfC WORK GROUP
HEPTACHLOR EPOXIDE 001024-57-3
010399 DOW CHEMICAL CO 1958 MRID NO 00061912 AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460
US EPA 1986 RfD/RfC WORK GROUP
HEPTANE, N- 000142-82-5
005969 US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N HEPTANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
HEXABROMOBENZENE 000087-82-1
005970 MENDOZA CE. HM VIJAY. JB SHIELDS AND GW LAVER 1977 EFFECTS OF HEXABROMOBENZENE ON THE MALE RAT TOXICOL APPL PHARMACOL. 41: 127-130
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1985 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN!CITY) July 1997
HEXACHLOROBENZENE 000118-74-1
ARNOLD, DL, CA HOODIE. SH ET AL 1985 LONG-TERM TOXICITY OF IN THE RAT AND THE EFFECT OF DIETARY VITAMIN
A FOOD CHEM TOXICOL 23(9) 779-793.
US EPA 1991 DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROBENZENE PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE Qf WATER. WASHINGTON. DC
US EPA. 1988 RTD/RfC WORK GROUP
010900 US EPA 1990. RfD/RfC WORK GROUP
HEXACHLOROBUTADIENE 000087-68-3
010927 NTP (NATIONAL TOXICOLOGY PROGRAM) 1991. NTP REPORT ON THE TOXICITY STUDIES OF HEXACHLORO-1.3-BUTADIENE IN B6C3F1 MICE (FEED STUDIES)
YANG ET AL. 1989 HEXACHLOROBUTADIENE - SUBCHRONIC TOXICOLOGY STUDIES OF HEXACHLORO-1.3-BUTADIENE (HCBD) IN B6C3F1 NICE BY DIETARY
INCORPORATION J ENVIRON PATHOL TOXICOL ONCQL. P. 323-332
KQC16A RJ. DG KEYS. GC JERESEY. ET AL 1977 RESULTS OF A 2-YEAR CHRONIC TOXICITY STUDY WITH HEXACHLOROBUTADIENE IN RATS AM IND HYG
ASSOC J. 38: 589-602
US EPA, 1993 RfD/RfC WORK GROUP.
HEXACHLOROCYCLOHEXANE, DELTA- 000319-86-8
010495 US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONHENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
HEXACHLOROCYCLOHEXANE, EPSILON- 006108-10-7
010496 US EPA 1987 HEALTH AND ENVIRONHENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
HEXACHLOROCYCLOHEXANE, GAMMA- 000058-89-9
005537 ZOECON CORPORATION 1983 MRID NO 00128356 AVAILABLE FROM EPA WRITE TO FOI, EPA, WASHINGTON, DC 20460
US EPA, 1986 RfD/RfC WORK GROUP
010903 US EPA 1992 RfD/RfC WORK. GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
HEXACHLOROCYCLOPENTADIENE 000077-47-4
005299 ABDO. KM. CA MONTGOMERY. WM KLUWE ET AL. 1984 TOXICITY OF HEXACHLOROCYCLOPENTADIENE: SUBCHRONIC (13-WEEK) ADMINISTRATION BY GAVAGE TO
F344 RATS AND B6C3F1 MICE. J APPL TOXICOL 4: 75-81
US EPA 1991. DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROCYCLOPENTANE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC
US EPA. 1985 RfD/RfC WORK GROUP
010445 ABDO. KM. CA MONTGOMERY. J ROYCROFT. HA RAGAN. RA RENNE. WE GIDDINS 1986 SUBCHRONIC (13-WEEK) OINHALATION TOXCICITY OF
HEXACHLOROCYCLOPENTADIENE (HCCPO) IN F344 RATS AND B6C3F1 MICE ABSTRACT SUBMITTED TO THE SOCIETY OF TOXICOLOGY FROM THE 1986 MEETING.
BATTELLE NORTHWEST LABORATORIES 1984. INHALATION CARCINOGENESIS BIOASSAY STUDY. SUBCHRONIC STUDY REPORT ON HEXACHLOROCYCLOPENTADIENE IN
RATS SUBMITTED TO THE NATIONAL TOXICOLOGY PROGRAM
US EPA. 1988 HEALTH AND DNVIRONMENTAL EFFECTS DOCUMENT FOR HEXACHLOROCYCLOPENTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROCYCLOPENTADIENE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON. DC.
HEXACHLOROETHANE 000067-72-1
005518 GORZINSKI, SJ, RJ NOLAN. SB MCCOLLISTER. ET AL 1985. SUBCHRONIC ORAL TOXICITY. TISSUE DISTRIBUTION AND CLEARANCE OF HEXACHLOROETHANE IN
THE RAT DRUG CHEM TOXICOL 8(3) 155-169
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HEXACHLOROETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA 1987 RfO/RfC WORK GROUP.
010904 US EPA. 1992 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
HEXACHLOROPHENE 000070-30-4
005972 NATIONWIDE CHEMICAL CORPORATION 1974 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO 00055365 AVAILABLE FROM EPA WRITE
TO FOI, EPA, WASHINGTON. DC 20460
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROPHENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA. 1988 RfD/RfC WORK GROUP
HEXAMETHYLENE DIAMINE 000124-09-4
005973 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXAMETHYLENEOIAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSHENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, OC
HEXANE, N- 000110-54-3
005974 KRASAVAGE WJ, JL Q'QQNQGHUE, GO DIVINCENZO AND TERHAAR. 1980 RELATIVE NEUROTOXICITY OF METHYL-N-BUTYL KETONE. N-HEXANE AND THEIR
METABOLITES. TOXICOL APPL PHARMACOL 52(3) 433-441.
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FDR N-HEXANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
010273 SANAGI S. Y SEKI, K SUGIMOTO AND M HIRATA 1980. PERIPHERAL NERVOUS SYSTEM FUNCTIONS OF WORKERS EXPOSED TO N-HEXANE AT A LOW LEVEL INT
ARCH OCCUP ENVIRON HEALTH. 47, 69-79.
HEXANONE, 2- 000591-78-6
005976 US EPA. 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N-HEXANONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
HYDROGEN SULFIDE 007783-06-4
010269 WATTERAU H. W OECKERT AND UG KNAPE. 1964 TESTS FOR THE APPLICATION OF DRIED GREEN FODDER WITH HIGH H2S CONTENT (EXPERIMENTS WITH POULTRY
AND FATTENED PIGS). LETTIN FEEDS TESTING CENTER AND FEEDING HALL. FEEDS SCIENCE FETTERUNG 5 383-393
US EPA 1985 RfD/RfC WORK GROUP.
010354 CUT 1983 90 DAY VAPOR INHALATION TOXICITY STUDY OF HYDROGEN SULFIDE IN B6C3F1 MICE EPA OTS PUBLIC FILES FICHE N00000255-0 DOCUMENT
NO FYI-OTS-0883-0255.
US EPA. 1990 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HYDROGEN SULFIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH, FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA 1995 RfD/RfC WORK GROUP
HYDROQUINONE 000123-31-9
005526 CARLSON. AJ AND NR BREWER 1953 TOXICITY STUDIES ON HYDROQUINONE PROC SOC EXP BIOL MED. 84- 684-688
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HYDROQUINONE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
010905 US EPA 1990. RfD/RfC WORK GROUP.
IRON 007439-89-6
005527 US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR IRON ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF EMERGENCY AND
REMEDIAL RESPONSE. WASHINGTON. DC
ISOBUTYL ALCOHOL 000078-83-1
005977 US EPA 1986. RAT ORAL SUBCHRONIC TOXICITY WITH ISOBUTYL ALCOHOL OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOBUTANOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC
US EPA 1986 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ISOPHORONE 000078-59-1
005910 NOR-AM AGRICULTURAL PRODUCTS, INC- 1972 MRIO NO 00123976 AVAILABLE FROM EPA WRITE TO FOI, EPA, WASHINGTON. DC 20460
NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 TOXICOLOGY AND CARCINQGENESIS STUDIES OF ISOPHORONE (CAS NO 78-59-1) IN F344/N RATS AND B6C3F1
MICE (GAVAGE STUDIES) NTP TECH REPORT SER NO 291, NIH PUBL NO 86-2547.
US EPA. 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR ISOPHORONE. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER. WASHINGTON. DC.
US EPA 1989. RfD/RfC WORK GROUP,
010906 US EPA 1990 RfD/RfC WORK GROUP,
ISOPROPALIN 033820-53-0
005978 ELI LILY CO. 1985. CONFIDENTIAL BUSINESS INFORHATION. UNPUBLISHED STUDY
US EPA, 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOPROPALIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. OC
US EPA. 1986. RfD/RfC WORK GROUP
LACTONITRILE 000078-97-7
005783 US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
LEAD 007439-92-1
010447 TO IRIS
LEAD ALKYLS
010448 REFER TO IRIS.
LINURON 000330-55-2
005990 DU PONT OE AND COMPANY. INC. 1962. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY MRID NO 00018374, AVAILABLE FROM EPA.
WRITE TO FOI, EPA, WASHINGTON, DC 20460.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR LINURON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSHENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1986 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
MALATHION 000121-75-5
005991 MOELLER HC AND JA RIDER. 1962 PLASMA AND RED BLOOD CELL-CHOLINESTERASE ACTIVITY AS INDICATIONS OF THE THRESHOLD OF INCIPIENT TOXICITY OF
ETHYL-P-NITROPHENOL THIONEBENZENEPHOSPHORATE (EPN) AND MALATHION IN HUMAN BEINGS TOXICOL APPL PHARMACOL. 4: 123-130
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALATHION. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1987 RfO/RfC WORK GROUP
MALEIC ANHYDRIDE 000108-31-6
005992 JESSUP DC. D ALDRIDGE. JL SCHARDEIN AND M BLAIR. 1982 THREE-GENERATION REPRODUCTION STUDY IN RATS (MODIFIED TO A2-GENERATION STUDY).
MALEIC ANHYDRIDE IR-79-358. INTERNATIONAL RESEARCH AND DEVELOPMENT CORP. FOR MONSANTO CO., ST. LOUIS.MO. UNPUBLISHED 8D SUBMISSION.
MICROFICHE NO OTS 0206655. DOCUMENT ID 878214777
PREACHE M 1983 CHRONIC DIETARY ADMINISTRATION OF MALEIC ANHYDRIDE VOL 1 NARRATIVE FYI-OTS SUBMISSION 1283-0277 PREPARED BY ITT
RESEARCH INSTITUTE FOR CHEMICAL INDUSTRY INSTITUTE OF TECHNOLOGY. RESEARCH TRIANGLE PARK. NC.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALEIC ANHYDRIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1988 RfD/RfC WORK GROUP
MALEIC HYDRAZIDE 000123-33-1
005993 UNIROYAL CHEMICAL CO 1981 ACCESSION NO 250523
US EPA. 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MALEIC ANHYDRIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
US EPA 1986 RfD/RfC WORK GROUP
MALONONITRILE 000109-77-3
005994 PANOV I. M ZLATEVA AND G ANTOV 1972. TOXICOLOGICAL CHARACTERISTICS OF DICYANOMETHANE. CHRONIC EFFECTS IN WHITE RATS KHIG
ZDRAVEOPAZVANE 15(6) 553-562
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MALONONITRILE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
HANCOZEB 008018-01-7
005995 US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MANCOZEB PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC
012427-38-2
005996 MANEB DATA TASK FORCE 1986. MRID NO 00161552 (CITED IN US EPA 1987.) AVAILABLE FROM EPA WRITE TO FOI, EPA, WASHINGTON, DC 20460
ROHM AND HAAS CO. 1977 MRID NO 00129980. (CITED IN US EPA 1987.) AVAILABLE FROM EPA. WRITE TO FOI. EPA, WASHINGTON. DC 20460
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MANEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
MANGANESE 007439-96-5
010851 WHO (WORLD HEALTH ORGANIZATION) 2973 TRACE ELEMENTS IN HUMAN NUTRITION' MANGANESE REPORT OF A WHO EXPERT COMMITTEE TECHNICAL REPORT
SERVICE, 532, WHO, GENEVA, SWITZERLAND PP 34-36
SCHROEDER HA, JJ BALASSA, IH TIPTON 1966 ESSENTIAL TRACE METALS IN MAN: MANGANESE, A STUDY IN HOMEOSTASIS. J DIS 19, 545-571
NRC (NATIONAL RESEARCH COUNCIL) 1989 RECOMMENDED DIETARY ALLOWANCES. 10TH ED FOOD AND NUTRITION BOARD, NATIONAL RESEARCH COUNCIL.
NATIONAL ACADEMY PRESS. WASHINGTON. DC. PP 230-235
US EPA 1992. RfD/RfC WORK GROUP.
010959 ROELS HA. P GHYSELEN. JP BUCHET, E CEULEMANS. RR LAIMRYS 1992. ASSESSMENT OF THE PERMISSIBLE EXPOSURE LEVEL TO MANGANESE IN WORKERS
EXPOSED TO MANGANESE DIOXIDE DUST. BR J IND MED 49' 25-34
ROELS H. R LAUWERYS. JP BUCHET ET AL 1987 EPIDEMIOLOGICAL SURVEY AMONG WORKERS EXPOSED TO MANGANESE EFFECTS ON LUNG, CENTRAL NERVOUS
SYSTEM, AND SOME BIOLOGICAL INDICES AM J IND MED 11, 307-327
US EPA. 1993 RfD/RfC WORK GROUP
MEPHQSFOLAN 000950-10-7
005997 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MEPHQSFOLAN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
MERCURIC CHLORIDE 007487-94-7
005800 ANDRES P 1984. IGA-AGG DISEASE IN THE INTESTINE OF BROWN-NORWAY RATS INGESTING MERCURIC CHLORIDE CLIN IMMUNOL IMMUNOPATHOL 20 488-
494.
BERNAUDIN JF. E DRUET. P DRUET. R MASSE. 1981 INHALATION OR INGESTION OF ORGANIC OR INORGANIC MERCURIALS PRODUCES AUTO-IMMUNE DISEASE
IN RATS CLIN IMMUNOL IMMUNOPATHOL 20. 129-135
DRUET P. E DRUET. F POTOEVIN C SAPIN. 1978. IMMUNE-TYPE GLOMERULONEPHRITIS INDUCED BY HG CL2 IN THE BROWN NORWAY RAT ANN IMMUNOL 129C:
777-702
US EPA 1987. PEER REVIEW WORKSHOP ON MERCURY ISSUES. OCTOBER 26-27. 1987. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.
OH.
US EPA 1988 RfD/RfC WORK GROUP
US EPA 1995 MERCURY STUDY REPORT TO CONGRESS OFFICE OF RESEARCH AND DEVELOPMENT WASHINGTON. DC EXTERNAL REVIEW DRAFT
EPA/600/P-94/002AB
MERCURY ELEMENTAL 007439-97-6
010270 FAWER RF. V DERIBAUPIERRE. MP GUILLEMIN ET AL 1983. MEASUREMENT OF HAND TREMOR INDUCED BY INDUSTRIAL EXPOSURE TO METALLIC MERCURY J IND
MED 40 204-208.
PIIKIVI L 1989 CARDIOVASCULAR REFLEXES AND LONG-TERM EXPOSURE TO MERCURY VAPOR. INT ARCH OCCUP ENVIRON HEALTH. 61. 391-395
PIIKIVI L AND H HANNINEN 1989. SUBJECTIVE SYMPTOMS AND PSYCHOLOGICAL PERFORMANCE OF CHLORINE-ALKALI WORKERS SCANDJ WORK ENVIRON HEALTH.
15 69-74
PIIKIVI L AND V TOLONEN 1989 EEG FINDINGS IN CHLOR-ALKALI WORKERS SUBJECTED TO LONG-TERM EXPOSURE TO MERCURY VAPOR BR J IND MED 46-
370-375
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR MERCURY PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1990 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITV) July 1997
MERPHOS 000150-50-5
005998 ABOU-DQNIA MB. DG GRAHAM PR TIMMONS AND BL REICHERT 1980. LATE ACUTE. DELAYED NEUROTOXIC AND CHOLINERGIC EFFECTS OF
S.S.S-TRISUTYLPHOSPHOROTRITHIOITE (MERPHOS) IN HENS TOXICOL APPL PHARMACOL 53: 439-457.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.
US EPA 1987 RfO/RfC WORK GROUP
010907 US EPA 1992 RfO/RfC WORK GROUP.
MERPHOS OXIDE 000078-48-8
005999 ABOU-OONIA MB, DG GRAHAM. KM ABDO AND AA KOMEIL 1979 DELAYED NEUROTOXIC, LATE ACUTE AND CHOLINERGIC EFFECTS OF
S.S.S-TRIBUTYLPHOSPHOROTRITHIOATE (OEF). SUBCHRONIC (90 DAYS) ADMINISTRATION IN HENS TOXICOLOGY 14 229-243.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MERPHOS OXIDE PREPARED 6Y THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC.
US EPA. 1987. RfD/RfC WORK GROUP
010908 US EPA. 1992. RfD/RfC WORK GROUP
METHACRYLONITRILE 000126-98-7
005812 POZZANI, UC. CR KINKEAD AND JM KING 1968 THE MAMMALIAN TOXICITY OF METHACRYLONITRILE AM IND HYG ASSOC J 29(3) 202-210
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
US EPA. 1987. RfO/RfC WORK GROUP.
METHANOL 000067-56-1
010271 US EPA. 1986. RAT ORAL SUBCHRONIC TOXICITY STUDY WITH METHANOL. OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1988. RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
METHOMYL 016752-77-5
E I OU PONT DE NEMOURS AND COMPANY, INC 1968 MRIO 0007091, 00009012 AVAILABLE FROM EPA. WRITE TO F01. EPA, WASHINGTON. DC 20460.
US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHOMYL. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH
US EPA, 1986 RFD/RFC WORK GROUP.
METHOXYCHLOR 000072-43-5
010357 KINCAID ENTERPRISES. INC. 1989 MRID NO 0015992 AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON, DC 20460
US EPA 1990 RfO/RfC WORK GROUP
US EPA 1991 RfO/RfC WORK
METHOXYETHANOL ACETATE, 2- 000110-49-6
010497 MILLER RR, LL CALHOUN AND BL YANO. 1982 ETHYLENE GLYCOL MONOMETHYL ETHER 13-WEEK VAPOR INHALATION STUDY IN MALE RABBITS. REPORT
PREPARED FOR THE CHEMICAL MANUFACTURERS ASSOCIATION. MARCH 25, 1982
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXYETHANOL ACETATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
METHOXYETHANOL, 2- 000109-86-4
010372 MILLER RR, JA AYRES. JL YOUNG ET AL. 1983 ETHYLENE GLYCOL MONOMETHYL ETHER I SUBCHRONIC VAPOR INHALATION STUDY WITH RATS AND RABBITS
FUND APPL TQXICQL 3(1) 49-54
US EPA 1990 RfO/RfC WORK GROU^
METHYL ACETATE 000079-20-9
010002 TOXICITY RESEARCH LABORATORY 1986 RAT ORAL SUBCHRONIC TOXICITY STUDY WITH METHANOL SPONSORED BY OFFICE OF SOLID WASTE. US EPA.
WASHINGTON, DC
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ACETATE PREPARED 8Y THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
METHYL ACRYLATE 000096-33-3
010498 KLIMISCH HJ AND W REININGHAUS. 1984, CARCINOGEN ICITY OF ACRYLATES LONG-TERM INHALATION STUDIES ON METHYL ACRYLATE (MA) AND N-BUTYL
ACRYLATE (BA) IN RATS TOXICOLOGIST 4(1) 53
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ACRYLATE PREPARED 8Y THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
METHYL ETHYL KETONE 000078-93-3
010853 COX, GE. 1975 TOXICITY STUDIES IN RATS WITH 2-BUTANQL* INCLUDING GROWTH. REPRODUCTION, AND TERATOGENIC OBSERVATIONS FOOD AND DRUG
RESEARCH LABORATORIES. INC (91MR R 1673)
US EPA. 1992. RfD/RfC WORK GROUP.
010845 SCHWETZ BA, TJ MAST, RJ WEIGEL. ET AL 1991 DEVELOPMENTAL TOXICITY OF INHALED METHYL ETHYL KETONE IN MICE FUND APPL TOXICOL 16
742-748
MAST, TJ, JA DILL. JJ EVANOFF, ET AL. 1989 INHALATION DEVELOPMENTAL TOXICOLOGY STUDIES- TERATOLOGY STUDY OF METHYLETHYL KETONE IN MICE
FINAL REPORT PREPARED BY PACIFIC NORTHWEST LABORATORY. BATELLE MEMORIAL INSTITUTE, FOR THE NATIONAL TOXICOLOGY PROGRAM, WASHINGTON, DC
PNL-6833 UC-408
US EPA. 1991 RfO/RfC WORK GROUP
METHYL ETHYL KETONE PEROXIDE 001338-23-4
010948 US EPA 1993. RfD/RfC WORK GROUP
METHYL ISOBUTYL KETONE 000108-10-1
010949 MICROBIOLOGICAL ASSOCIATES 1986 SUBCHRONIC TOXICITY OF METHYL ISOBUTYL KETONE IN SPRAGUE-DAWLEY RATS. PERFORMED FOR RESEARCH TRIANGLE
INSTITUTE, PO BOX 12194, RESEARCH TRIANGLE PARK. NC, 27709, FINAL REPORT STUDY NO 522104.
US EPA. 1993. RfD/RfC WORK GROUP
METHYL ISOCYANATE 000624-83-9
010013 US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ISOCYANATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA 1990. RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY) July 1997
METHYLMERCURY 022967-92-6
010970 MARSH, D 0 . T W CLARKSON. C COX ET AL 1987. FETAL METHYLMERCURY POISONING RELATIONSHIP BETWEEN CONCENTRATION IN SINGLE STRANDS OF
MATERNAL HAIR AND CHILD EFFECTS. ARCH NEUROL 44 1017-1022.
SEAFOOD SAFETY 1991 COMMITTEE ON EVALUATION OF THE SAFETY OF FISHERY PRODUCTS. CHAPTER ON METHYLMERCURY FDA RISK ASSESSMENT AND
CURRENT REGULATIONS. NATIONAL ACADEMY PRESS. WASHINGTON. DC. P 196-221
U S EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR MERCURY PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF WATER REGULATION AND STANDARDS. WASHINGTON. DC.
EPA/440/5-80/058 NTIS PB 81-117699
U.S EPA. 1995 MERCURY STUDY REPORT TO CONGRESS OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON. DC EXTERNAL REVIEW DRAFT.
EPA/600/P-94/002Ab
U.S. EPA 1994. RfD/RfC WORK GROUP
METHYL METHACRYLATE 000080-62-6
010014 BORZELLECA JF. PS LARSON, GR HENNIGAR, ET AL 1964 STUDIES ON THE CHRONIC ORAL TOXICITY OF MONOMERIC ETHYL ACRYLATE AND METHYL
METHACRYLATE TOXICOL APPL PHARMACOL 6 29-36
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL METHACRYLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
METHYL PARATHION 000298-00-0
010015 MONSANTO CO 1983 ACCESSION NO 252501-252503. 253346. 253372-253374 MRID NO 000139023. 00143965. 00145507 AVAILABLE FROM EPA WRITE
TO FOI. EPA. WASHINGTON. DC 20460.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL PARATHION PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1986 RfD/RfC WORK GROUP
010846 DALY. IW AND WE RINEHART 1980 A THREE-MONTH FEEDING STUDY OF METHYL PARATHION IN RATS PROJECT 77-2054 MRID NO 74299 AVAILABLE FROM
EPA WRITE TO FOI. EPA. WASHINGTON, DC 20460
US EPA. 1991 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYL PARATHION PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
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(OTHER THAN CARCINQGENICITY) July 1997
STYRENE (MIXED ISOMERS) 025013-15-4
010500 FINAL CHRONIC REPORT PERFORMED FOR THE NTP UNDER CONTRACT NO N01-ES-3BG42,
US EPA 1987, HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYL STYRENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
HETHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2- 000094-81-5
010008 RHODIA. INC 1970 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRIO NO 00116345 AVAILABLE FROM EPA WRITE TO FOI. EPA,
WASHINGTON. DC 20460
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MCPA AND MCPB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC
US EPA 1990 INTEGRATED RISK INFORMATION SYSTEM (IRIS). ONLINE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI, OH
US EPA 1987 RfD/RfC WORK GROUP
HETHYL-4-CHLOROPHENOXY) PROPIONIC ACID, 2-(2- 000093-65-2
010009 BASF AKTIEGERELLSCHAFT. 1985. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY MRID NO 00158359 AVAILABLE FROM EPA WRITE TO FOI.
EPA. WASHINGTON. DC 20460
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MCPP PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1988 RfD/RfC WORK GROUP.
METHYL-4-CHLOROPHENOXYACETIC ACID, 2- 000094-74-6
010007 INDUSTRY TASK FORCE ON MCPA RESEARCH DATA 1986 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY MRID NO 00164352 AVAILABLE FROM
EPA WRITE TO FOI. ERA, WASHINGTON. DC 20460
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MCPA AND MCPB PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1988 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
METHYLCYCLOHEXANE 000108-87-2
010431 KINKEAD ER. CC HAUN MG SCHNEIDER. ET AL 1985. CHRONIC INHALATION EXPOSURE OF EXPERIMENTAL ANIMALS TO METHYLCYCLOHEXANE GOVT REPORTS
ANNOUNCEMENTS AND INDEX. ISSUE 21 29 P.
US EPA. 1991 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYLCYCLOHEXANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
METHYLENE BROMIDE 000074-95-3
010501 KEYES DG. JW HENCK, GC JERSEY. RJ KOC1BA. DJ SCHWETZ AND TO LANDRY 1982 METHYLENE BROMIDE A 90-DAY REPEATED INHALATION TOXICITY STUDY
IN RATS AND DOGS WITH A SUBSEQUENT TWO-YEAR HOLDING PERIOD FOR RATS. TOXICOLOGY RESEARCH LAB. HEALTH AND ENVIRONMENTAL SCIENCES. DOW
CHEMICAL CO.. MIDLAND. MI
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYLENE BROMIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
METHYLENE CHLORIDE / (DICHLOROMETHANE) 000075-09-2
005553 NATIONAL COFFEE ASSOCIATION 1982. 24-MONTH CHRONIC TOXICITY AND ONCOGENICITY STUDY OF METHYLENE CHLORIDE IN RATS FINAL REPORT PREPARED
BY HAZLETON LABORATORIES AMERICA. INC.. VIENNA. VA UNPUBLISHED
US EPA 1985 DRINKING WATER CRITERIA DOCUMENT FOR METHYLENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON. DC.
US EPA. 1985 RfD/RfC WORK GROUP
005552 NITSCHKE KD. JD BUREK. TJ BELL. RJ KOCIBA. LW RAMPEY AND MJ MCKENNA 1988 METHYLENE CHLORIDE- A 2-YEAR INHALATION TOXICITY AND
ONCOGENICITY STUDY IN RATS. FUND APPL TOXICOL. 10: 1-12.
US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR METHYLENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
METHYLENE-BISC2-CHLOROANILINE). 4.4'- 000101-14-4
010413 STULA EF. JR BARNES. H SHERMAN. CF REINHARDY AND JA ZAPP.1977 URINARY BLADDER TUMORS IN DOGS FROM 4.4'-METHYLENE-BIS(2-CHLOROANILINE)
(MOCA) J ENVIRON PATHOL TOXICOL 1(1)- 31-50
US EPA. 1990 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4.4'-METHYLENE-BIS(2-CHLOROANILINE) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON DC
010933 US EPA. 1993 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN1CITY)
July 1997
METHYLENEDIPHENYL ISOCYANATE, 4,4- / (DIPHENYLMETHANE DIISOCYANATE) 000101-68-8
010449 REUZEL PGJ, JHG ARTS, MHM KUYPERS. ET AL 1990 CHRONIC TOXICITY/CARCINQGENICJTY INHALATION STUDY OF POLYMERIC METHYLENEDIPHENYL
DIISOCYANATE AEROSOL IN RATS FINAL REPORT PREPARED BY CIVO INSTITUTE FOR THE INTERNATIONAL ISOCYANATE INSTITUTE
REUZEL PGJ, JHG ARTS, LG LOMAX, ET AL 1998 CHRONIC INHALATION AND CARCINOGENI CITY STUDY OF RESPIRABLE POLYMERIC METHYLENE DIPHENYL
DIISOCYANATE (POLYMERIC MOD AEROSOL IN RATS. FUND APPL TOXICOL 22 195-210
METQLACHLQR
010950
METRIBUZIN
010928
MIREX
010841
US EPA 1993. RfD/RfC WORK GROUP
051218-45-2
TISDEL M. T JACKSON, P MACWILLIAHS ET AL 1983 TWO-YEAR CHRONIC ORAL TOXICITY AND ONCOGENIC1TY STUDY WITH METOLACHLOR IN ALBINO RATS
STUDY NO 80030. FINAL REPORT (UNPUBLISHED STUDY RECEIVED MAY 24. 1983 100-587. PREPARED BY HAZLETON RALTECH. INC . SUBMITTED BY
CIBA-6EIGY CORP , GREENSBORO. NC. CDL 250369-A, 250370, 250371, 250272, 259373, 259374. 259375 ) REFERRED TO AS CIBA-GEIGY, 1983 IN U S
EPA (1993) MRID 00129377 AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON, DC 20460
SMITH SH. CK O'LOUGHLIN. CM SALAMON ET AL 1981 TWO-GENERATION REPRODUCTION STUDY IN ALBINO RATS WITH METOLACHLOR TECHNICAL' STUDY NO
450-0272. FINAL REPORT (UNPUBLISHED STUDY RECEIVED SEPTEMBER 30. 1981 100-597 PREPARED BY WHITTAKER CORP . SUBMITTED BY
CIBA-GEIGY CORP . GREENSBORO. NC CDL 245959-A. 245960, 245961,) REFERRED TO AS CI8A-GEIGY (1981) IN U S EPA (1993) MRID 00080897
AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON. DC 20460,
US EPA 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METOLACHLOR PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER, WASHINGTON. DC.
MOBAY CHEMICAL CORPORATION 1974
US EPA 1986 RfD/RfC WORK GROUP
021087-64-9
MRID 000061260 AVAILABLE FROM EPA WRITE TO FOI. EPA, WASHINGTON, DC 20460
US EPA 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METRIBUZIN PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL EFFECTS, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER, WASHINGTON, DC
NTP (NATIONAL TOXICOLOGY PROGRAM)
STUDIES), NTP TR 313
US EPA 1992 RFD/RFC WORK GROUP
1990
002385-85-5
TOXICOLOGY AND CARCINOGENESIS STUDIES OF MIREX (CAS NO 2385-85-5) IN F344/N RATS
(FEED
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
MOLINATE 002212-67-1
010017 STAUFFER CHEMICAL COMPANY 1981 MRID NO 00079209. AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON, DC 20460
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MOLINATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.
US EPA 1988. RfO/RTC WORK GROUP.
MOLYBDENUM 007439-98-7
010489 KOLVAL'SKIY VV. GA YAROVAYA AND DM SHMAVONYAN. 1961 CHANGES OF PURINE METABOLISM IN MAN AND ANIMALS UNDER CONDITIONS OF MOLYBDENUM
BIOGEOCHEMICAL PROVINCES. ZH OBSHCH BIOL. 22- 179-191. (IN RUSSIAN. TRANSLATION)
US EPA 1991 RfD/RfC WORK GROUP.
MONOCHLORAMINE 010599-90-3
010517 NTP (NATIONAL TOXICOLOGY PROGRAM). 1990 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORINATED AND
CHLORAMINATED WATER IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES) NTP TR 392. NATIONAL INSTITUTES OF HEALTH
US EPA 1992. DRINKING WATER CRITERIA DOCUMENT FOR CHLORAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE HEALTH AND ECOLOGICAL CRITERIA DIVISION. OFFICE OF SCIENCE AND
TECHNOLOGY. OFFICE OF WATER. WASHINGTON. DC
US EPA 1992 RfD/RfC WORK GROUP
NAPHTHOQUINONE. 1,4- 000130-15-4
010020 US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.4-NAPHTHOQUINONE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA 1991 RfD/RfC WORK GROUP
NICKEL CYANIDE 000557-19-7
010953 US EPA 1993 RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINQGENICITY) July 1997
NICKEL, SOLUBLE SALTS VARIOUS
005579 AMBROSE. AM, OS LARSON. JR BORZELLECA AND GR HENNIGAR, JR. 1976 LONG-TERM TOXICOLOGIC ASSESSMENT OF NICKEL IN RATS AND DOGS J GOOD SCI
TECHNOL. 13 181-187
US EPA. 1991 DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR NICKEL BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON, DC
US EPA 1991 RfD/RfC WORK GROUP
NICOTINONITRILE 000100-54-9
005584 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,
OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
NITRIC OXIDE 010102-43-9
010451 REFER TO APPENDIX A; TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
US EPA. 1994 RfO/RfC WORK GROUP.
NITRITE 014797-65-0
010021 WALTON G 1951 SURVEY OF LITERATURE RELATING TO INFANT METHEMOGLOBINEMIA DUE TO NITRATE-CONTAMINATED WATER AM J PUB HEALTH. 41-
986-996
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITRITE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
US EPA 1992. RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
July 1997
NITROANILINE, 2-
010936 US EPA
000088-74-4
1992 RfO/RfC WORK GROUP.
010935 BIO/DYNAMICS 1983 PROJECT NO (BD-82-27Q) A FOUR WEEK INHALATION STUDY OF ORTHO-NITROANILINE IN MALE RATS, FINAL REPORT
DR. RASHMI NAIR, MONSANTO CO., AUGUST 16. 1983. EPA 87821478 IOTS0206486. P. 1A-17. 32-42. 46-48, 55-58, 62-67.
SUBMITTED TO
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROANILINE (0-. M-. P-). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-NITROANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
NITROANILINE, M- 000099-09-2
010400 US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 3-NITROANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
NITROANILINE, P- 000100-01-6
010024 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROANILINE (0-, M-. P-) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
000098-95-3
005589 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1984. NINETY-DAY INHALATION STUDY OF NITROBENZENE IN F-344 RATS. CD RATS AND B6C3F1
MICE WITH COVER LETTER DATED 6/24/84 AND EPA RESPONSE DATED 8/06/84. UNPUBLISHED STUDY. FYI-OTS-0784-0333 AND COMPUTER PRINT-OUT OF
PATHOLOGY FINDING
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR NITROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA 1985. RfO/RfC WORK GROUP
NITROFURANTOIN 000067-20-9
005593 SRI (SOUTHERN RESEARCH INSTITUTE) 1980 SUBCHRONIC TOXICITY REPORT ON NITROFURANTOIN (C55196) IN FISCHER-344 RATS AND B6C3F1 MICE
TRACOR JIT CO, INC, ROCKVILLE, MO, CONTRACT NOS N01-CP-43350 AND 78-65-106002 US EPA
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITROFURANS, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
NITROGEN DIOXIDE 010102-44-0
010402 US EPA. 1994. RfD/RfC WORK GROUP.
010912 REFER TO APPENDIX A TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
NITROGEN OXIDES
010170 US EPA 1982. AIR QUALITY CRITERIA FOR OXIDES OF NITROGEN. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. RESEARCH TRIANGLE PARK. NC. EPA
6QO/8-82-026F NTIS PB83-163337
NITROMETHANE 000075-52-5
010026 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROMETHANE PREPARED BY THE OFFICE Of HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
NITROPHENOLS
005594 US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR NITROPHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
NITROPROPANE, 2- OOOJJ79-46-9
010374 ANGUS CHEMICAL CO 1985 FINAL REPORT. CHRONIC INHALATION EXPOSURE TO RATS TO VAPORS OF 2-NITROPROPANE AT 100 PPM PREPARED BY COULSTON
INTERNATIONAL CORP FOR ANGUS CHEMICAL CO OTS NO 204292. DOC NO 8EHQ-0985-0170 FICHE NO 0200504.
ANGUS CHEMICAL CO. 1985. CHRONIC INHALATION OF 200 PPM OF2-NITROPROPANE IN RATS. PREPARED BY COULSTON INTERNATIONAL CORP (MAY 1978) FOR
ANGUS CHEMICAL CO OTS NO 204292 DOC NO 8EHQ-0985-0170 FICHE NO 0200504
GRIFFIN TB, F COULSTON AND AA STEIN. 1980 CHRONIC INHALATION EXPOSURE OF RATS TO VAPORS OF 2-NITROPROPANE AT 25 PPM ECOTOXICOL ENVIRON
SAF 4(3): 267-281
GRIFFIN TB, AA STEIN. F COULSTON. 1981 HISTOLOGICAL STUDY OF TISSUES AND ORGANS FROM RATS EXPOSED TO VAPORS OF 2-NITROPROPANE AT 25 PPM
ECOTOXOCOL ENVIRON SAF 5(2). 194-201
US EPA 1990 RfD/RfC WORK GROUP
NITROSODIPHENYLAMINE, P- 000156-10-5
010027 US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
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(OTHER THAN CARCINOGEN1CITY) July 1997
NITROTOLUENE, M- 000099-08-1
010029 CISS M, N HUYEN. H DUTERTRE, N PHU-LICH AND R TRUHAUT 1980. TOXICOLOGICAL STUDY OF NITROTOLUENES- LONG-TERM TOXICITY. DAKAR MEDICAL 25.
293-302.
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROTOLUENES (0-. M-. P-) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
NITROTOLUENE. 0- 000088-72-2
010028 C1SS M. N HUYEN. H DUTERTRE. N PHU-LICH AND R TRUHAUT 1980. TOXICOLOGICAL STUDY OF NITROTOLUENES LONG-TERM TOXICITY DAKAR MEDICAL 25
293-302
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROTOLUENES (0-. M-. P-) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
NITROTOLUENE, P- 000099-99-0
010030 CISS M. N HUYEN. H DUTERTRE. N PHU-LICH AND R TRUHAUT 1980 TOXICOLOGICAL STUDY OF NITROTOLUENES: LONG-TERM TOXICITY DAKAR MEDICAL 25
293-302
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROTOLUENES (0-. M-. P-). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
OCTABROMODIPHENYL ETHER 032536-52-0
010032 CARLSON GP 1980 INDUCTION OF XENOBIOTIC METABOLISM IN RATS BY BROMINATED DIPHENYL ETHERS ADMINISTERED FOR 90 DAYS TOXICOL LETT. 6:
207-212
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC
US EPA 1986. RfD/RfC WORK GROUP.
OCTAMETHYLPYROPHOSPHORAMIDE 000152-16-9
010031 RIDER JA. HC MOELLER. EJ PULETT1 AND JI SWADER 1969 TOXICITY OF PARATHION. SYSTOX. OCTAMETHYLPYROPHOSPHORAMINE AND METHYL PARATHION IN
MAN TOXICOL APPL PHARMACOL 14(3). 603-611.
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR OCTAMETHYLPYROPHOSPHORAMIDE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC
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(OTHER THAN CARCINOGENICITY) July 1997
OSMIUM TETROXIDE 020816-12-0
010954 US EPA 1993 RfD/RfC WORK GROUP
OZONE 010028-15-6
010171 US EPA 1986. AIR QUALITY CRITERIA FOR OZONE AND OTHER PHOTOCHEMICAL OXIDANTS, OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. RESEARCH
TRIANGLE PARK, NC. EPA 600/8-84-020F, NTIS PB87-142949
PARALDEHYDE 000123-63-7
010033 US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PARALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
PARATHION 000056-38-2
005598 US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR PARATHION PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
PARTICULATE MATTER
010034 US EPA. 1987 AIR QUALITY CRITERIA FOR PARTICULATE MATTER AND SULFUR OXIDES OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, RESEARCH
TRIANGLE PARK, NC EPA 6QQ/8-82-029F.NTIS PB84-156777.
PEBULATE 001114-71-2
010036 US EPA, 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PEBULATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC,
PENDIMETHALIN 040487-42-1
010037 AMERICAN CYANAMID COMPANY. 1979 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY MRID NO 0058657. AVAILABLE FROM EPA WRITE TO FOI.
EPA, WASHINGTON. DC 20460
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PENDIMETHALIN. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC,
US EPA. 1987 RfD/RfC WORK GROUP.
PENTABROMOOIPHENYL ETHER 032534-81-9
010038 CARLSON GP. 1980. INDUCTION OF XENOBIOTIC METABOLISM IN RATS BY BROMINATED DIPHENYL ETHERS ADMINISTERED FOR 90 DAYS. TOXICOL LETT 6
207-212
US EPA 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC
US EPA 1986 RfD/RfC WORK GROUP
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(OTHER THAN CARCINOGENICITY) July 1997
PENTACHLOROBENZENE 000608-93-5
010039 UNDER R. T SCOTTI J GOLDSTEIN AND K MCELROY. 1980 ACUTE AND SUBCHRONIC TOXICITY OF PENTACHLOROBENZENE J ENVIRON PATHOL TOXICOL
4(5-6)- 183-196.
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PENTACHLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
US EPA 1985 RfD/RfC WORK GROUP.
PENTACHLOROCYCLOPENTADIENE 025329-35-5
005302 US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
PENTACHLORONITROBENZENE 000082-68-8
010040 OLIN CORPORATION 1968 MRIO NO 000114201 AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PENTACHLORONITROBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1987 RfO/RfC WORK GROUP
PENTACHLOROPHENOL 000087-86-5
005600 SCHWETZ. BA. JF QUAST, PA KEELER ET AL. 1978 RESULTS OF TWO-YEAR TOXICITY AND REPRODUCTION STUDIES ON PENTACHLOROPHENOL IN RATS IN
PENTACHLOROPHENOL CHEMISTRY, PHARMACOLOGY AND ENVIRONMENTAL TOXICOLOGY. KR RAO, ED PLENUM PRESS, NEW YORK. P301 CITED IN US EPA. 1985
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PENTACHLOROPHENOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA 1984 HEALTH EFFECTS ASSESSMENT.FOR PENTACHLOROPHENOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1985 RfD/RfC WORK GROUP
PENTACHLOROPROPENE, 1.1.2.3.3.- 001600-37-9
010041 US EPA 1983 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
PENTANE, N- 000109-66-0
005603 US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR N-PENTANE. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF EMERGENCY
AND REMEDIAL RESPONSE, WASHINGTON, DC
000085-01-8
005604 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENANTHRENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1994 RfD/RfC WORK GROUP
PHENOL 000108-95-2
005824 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. TERATOLOGIC EVALUATION OF PHENOL IN CO RATS. REPORT PREPARED BY THE RESEARCH TRIANGLE INSTITUTE.
RESEARCH TRIANGLE PARK. NC NTIS PB83-247726. GOVT REP ANNOUNCE INDEX 83(25): 6247
US EPA 1989 UPDATED HEALTH EFFECTS ASSESSMENT FOR PHENOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSHENT OFFICE, CINCINNATI, OH. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA. 1989. RfD/RfC WORK GROUP,
010913 US EPA. 1990. RfD/RfC WORK GROUP
PHENYLENEDIAMINE, M- 000108-45-2
010044 HOFER H AND R HRUBY. 1982 NINETY-DAY TOXICITY STUDY WITH M-PHENYLENEDIAMINE ON RATS OESTERR ZENT SEIBERSDORF (BER ) OEFZS
BER. NO 4155. P 50.
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0-. M-. P-). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
US EPA 1986 RfD/RfC WORK GROUP.
PHENYLENEDIAMINE. 0- 000095-54-5
010042 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0-. M-. P-). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON. DC.
PHENYLENEDIAMINE, P- 000106-50-3
010043 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0-. M-, P-) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON. DC.
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(OTHER THAN CARCINOGEN1CITY) July 1997
PHENYLMERCURIC ACETATE 000062-38-4
010277 FITZHUGH OG. AA NELSON. EP LAUG AND IM KUNZE. 1950 CHRONIC ORAL TOXICITIES OF MERCURIC PHENYL AND MERCURIC SALTS ARCH IND HYG OCOJP
MED. 2. 433-442.
US EPA. 1986. RfD/RfC WORK GROUP.
PHORATE 000298-02-2
010403 TUSING TW. 1956. 13-WEEK SUBACUTE THIMET FEEDING STUDY IN MALE AND FEMALE RATS. UNPUBLISHED REPORT OF THE AMERICAN CYANAMID CO. INITIAL
SCIENTIFIC AND MINI-ECONOMIC REVIEW OF PHORATE (THIMET) OFFICE OF PESTICIDE PROGRAMS. US EPA. WASHINGTON. DC
US EPA. 1985. SUMMARY OF ACCEPTABLE DAILY INTAKES (ADIS) FOR ORAL EXPOSURE PREPARED BY ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,
CINCINNATI. OH INTERNAL REVIEW DRAFT. MAY. 1985 ECAO-CIN-432
NAS (NATIONAL ACADEMY OF SCIENCES) 1977 DRINKING WATER AND HEALTH SAFE DRINKING WATER COMMITTEE, NATIONAL RESEARCH COUNCIL. NAS.
WASHINGTON. DC. P 613-620
PHOSGENE 000075-44-5
010045 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHOSGENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1990 RfD/RfC WORK GROUP.
PHOSPHINE 007803-51-2
010174 HACKENBERG. J 1972 CHRONIC INGESTION BY RATS OF STANDARD DIET TREATED WITH ALUMINUM PHOSPHIDE TOXICOL APPL PHARMACOL 23- 147-158.
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PHOSPHINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1985 RfD/RfC WORK GROUP.
010976 BARBOSA A. E ROSINOVA. J DEMPSEY AND AM BONIN. 1994 DETERMINATION OF GENOTOX2C AND OTHER EFFECTS IN MICE FOLLOWING SHORT-TERM.
REPEATED DOSE, AND SUBCHRONIC INHALATION EXPOSURE TO PHOSPHINE ENVIRON MOLEC MUTAGENESIS 24 81-88
US EPA 1995. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
PHOSPHORUS, WHITE 007723-14-0
010452 CONDRAY JR 1985. ELEMENTAL YELLQy ONE-GENERATION REPRODUCTION STUDY IN RATS. IR-82-215 MRID NO 401-189 CO ST
LOUIS, MO. AVAILABLE FROM EPA WRITE TO FOI, EPA, WASHINGTON, DC 20460.
US EPA 1990. RfO/RfC WORK GROUP.
PHOTOCHEMICAL OXIDANTS
010172 US EPA. 1986. AIR QUALITY CRITERIA FOR OZONE AND OTHER PHOTOCHEMICAL OXIDANTS. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. RESEARCH
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PHTHALIC ACID, M- 000121-91-5
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ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
PHTHALIC ACID, 0- 000088-99-3
010046 US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACIDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
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RESPONSE, WASHINGTON. DC
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(OTHER THAN CARCINOGENICITY) July 1997
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010049 NCI (NATIONAL CANCER INSTITUTE) 1979. BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO.
159 NTIS PB293594
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010847 NIELSEN. J. H WELINDER. A SCHUTZ AND S SKERFVING. 1988.SPECIFIC SERUM ANTIBODIES AGAINST PHTHALIC ANHYDRIDE IN OCCUPATIONALLY EXPOSED
SUBJECTS. J ALLERGY CLIN IMMUNOL 82 126-33
US EPA 1992. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PHTHALIC ANHYDRIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
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POLYBROMINATED BIPHENYLS
010050 NTP (NATIONAL TOXICOLOGY PROGRAM) 1983 CARCINOGENESIS STUDIES OF POLYBROMINATED BIPHENYL MIXTURE IN F344/N RATS AND B6C3F1 MICE (GAVAGE
STUDIES) FIREMASTER FF-1 CASE NO 67774-32-7 NTP, RESEARCH TRIANGLE PARK. NC
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR POLYBROMINATED BIPHENYLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
POTASSIUM CYANIDE 000151-50-8
010278 HOWARD JW AND RF HANZAL 1955 CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE AGRIC FOOD CHEM 3. 325-329.
PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS J
TOXICOL ENVIRON HEALTH 5 579-592
US EPA 1985 RfD/RfC WORK GROUP.
POTASSIUM SILVER CYANIDE 000506-61-6
010279 HOWARD JW AND RF HANZAL 1955 CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE AGRIC FOOD CHEM. 3. 325-329
PHILBRICK DJ. JB HOPKINS. DC HILL. JC ALEXANDER AND RG THOMSON 1979 EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS J
TOXICOL ENVIRON HEALTH 5 579-592
US EPA. 1985 RfO/RfC WORK GROUP
PROFLURALIN 026399-36-0
010051 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROFLURALIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) My 1997
PRONAMIDE 023950-58-5
ROHH & HAAS, CO 1970, ACC NOS 004417,
US EPA 1986 RfD/RfC WORK GROUP
PROPACHLOR 001918-16-7
010175 MONSANTO COMPANY. 1964 CONFIDENTIAL BUSINESS INFORMATION UNPUBLISHED STUDY. MRID NO 0093270. AVAILABLE FROM EPA. WRITE TO FOI. EPA.
WASHINGTON. DC 20460.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPACHLOR PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
US EPA 1986. RfD/RfC WORK GROUP.
PROPAZINE 000139-40-2
010052 GEIGY COMPANY 1980. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY ACCESSION NO 243353
US EPA. 1987 RfD/RfC WORK GROUP
PROPIONITRILE 000107-12-0
010053 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPIONITRILE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
PROPYL ALCOHOL. N- 000071-23-8
005627 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N-PROPYL ALCOHOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1397
PROPYLENE GLYCOL 000057-55-6
GAUNT. IF, RHB CARPANJNI, P GRASSO AND ABG LANSDOWN. 1972 LONG-TERM TOXICITY OF PROPYLENE GLYCOL IN RATS, FOOD COSMET TOXICOL. 10
151-162.
US EPA, 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR PROPYLENE GLYCOL PREPARED 8Y THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
005629 GUERRANT. NB, GP WHITLOCK. ML WOLFF AND RA DUTCHER. 1947.RESPONSE OF RATS TO DIETS CONTAINING VARYING AMOUNTS OF GLYCEROL AND PROPYLENE
GLYCOL. BULL NATL FORMULARY COMM. 15- 204-229. CITED IN INFORMATICS, INC. 1973
US EPA 1987 HEALTH AND ENVIRONHENTAL EFFECTS FOR PROPYLENE GLYCOL BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EHERGENCY RESPONSE,
WASHINGTON. QC
010914 US EPA. 1991 RfO/RfC WORK GROUP.
PROPYLENE GLYCOL MONOETHYL ETHER 001569-02-4
005488 SMYTH. HF. JR AND CP CARPENTER. 1948. FURTHER EXPERIENCE WITH THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY J IND HYG
TOXICOL 30 63-68.
US EPA. 1984 HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
010915 US EPA. 1991. RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
PROPYLENE GLYCOL MONOMETHYL ETHER 000107-98-2
005486 ROME. VK. DD MCCOLLISTER. HC SPENCER ET AL. 1954 TOXICOLOGY OF MONO-. DI-, AND TRI-PROPYLENE GLYCOL METHYL ETHERS.ARCH IND HYG OCCUR
MED. 9: 509-525.
US EPA. 1984 HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC. EPA 540/1-86-052.
US EPA. 1991. RfD/RfC WORK GROUP
010276 LANDRY TD. TS GUNSHOW AND BL YANO. 1983. PROPYLENE GLYCOL MONOMETHYL ETHER A 13-WEEK INHALATION STUDY IN RATS AND RABBITS. FUND APPL
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STUDIES ENVIRON HEALTH PERSPECT 57: 233-239.
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH, FOR THE OFFICE Of EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC EPA 540/1-86-052
PROPYLENE OXIDE 000075-56-9
010375 KUPER CF. PGJ REUZEL. VJ FERON. ET AL. 1988. CHRONIC INHALATION TOXICITY AND CARCINOGENICITY OF PROPYLENE OXIDE IN WISTAR RATS. FOOD CHEM
TOXICOL. 26(2)- 159-167,
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPYLENE OXIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA 1990 RfD/RfC WORK GROUP
PYRENE 000129-00-0
010176 US EPA 1989. MOUSE ORAL SUBCHRONIC TOXICITY STUDY OF PYRENE STUDY CONDUCTED BY TOXICITY RESEARCH LABORATORIES. MUSKEGON, 3MI FOR THE
OFFICE OF SOLID WASTE. WASHINGTON, DC.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR PYRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
US EPA 1991 DRINKING WATER CRITERIA DOCUMENT FOR PYRENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON, DC
US EPA 1989 RfD/RfC WORK GROUP
US EPA 1994 RfD/RfC WORK
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
PYRIDINE 000110-86-1
010055 US EPA 1986. PYRIDINE. 90-DAY SUBCHRONIC ORAL TOXICITY IN RATS SPONSORED BY OFFICE OF SOLID WASTE, WASHINGTON, DC.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PYRIDINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC
US EPA. 1987 RfD/RfC WORK GROUP.
RDX / (CYCLONITE) 000121-82-4
010056 LEVINE BS EM FUREDI. VS RAE. DE GORDON AND DM LISH 1984 DETERMINATION OF THE CHRONIC MAMMALIAN TOXICOLOGICAL EFFECTS OF RDX.
TWENTY-FOUR MONTH CHRONIC TOXICITY/CARCINOGENICITY STUDY OF HEXAHYORO-1.3.5-TRINITRO-1.3.5-TRIAZINE (RDX) IN THE FISCHER 344 RAT. NTIS
AD-A160774. VOL 1 347 P
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR RDX (CYCLONITE) PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA. 1988 RfD/RfC WORK GROUP.
RONNEL 000299-84-3
010057 MCCOLLISTER DD. F OYEN AND VK ROWE 1959. TOXICOLOGICAL STUDIES OF 0,0-DIMETHYL-0-(2.4,5-TRICHLOROPHENYL)PHOSPHOTHIOATE (RONNEL) IN
LABORATORY ANIMALS. J AGRIC FOOD CHEM. 7- 689
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR RONNEL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.
SELENIOUS ACID 007783-00-8
010504 YANG G, S YIN, L ZHOU. ET AL 1989. STUDIES OF SAFE MAXIMAL DAILY DIETARY SE-INTAKE IN A SELENIFEROUS AREA IN CHINA II RELATION BETWEEN
SE-INTAKE AND THE MANIFESTATION OF CLINICAL SIGNS AND CERTAIN BIOCHEMICAL ALTERATIONS IN BLOOD AND URINE J TRACE ELEM ELECTROLYTES
HEALTH DIS 3: 123-130.
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELENIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON
OC
US EPA. 1991 RfD/RfC WORK GROUP
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(OTHER THAN CARCINOGENICITY) July 1997
SELENIUM 007782-49-2
010404 YANG G. S YIN. L ZHOU. ET AL. 1989. STUDIES OF SAFE MAXIMAL DAILY DIETARY SE-INTAKE IN A SELENIFEROUS AREA IN CHINA. II. RELATION BETWEEN
SE-INTAKE AND THE MANIFESTATION OF CLINICAL SIGNS AND CERTAIN BIOCHEMICAL ALTERATIONS IN BLOOD AND URINE. J TRACE ELEM ELECTROLYTES
HEALTH DIS. 3 123-130
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELENIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
US EPA. 1991. RfO/RfC WORK GROUP
SELENOUREA 000630-10-4
010473 YANG C. S WANG. R ZHOU, AND S SUN 1983 ENDEMIC SELENIUM INTOXICATION OF HUMANS IN CHINA AM J CLIN NUTR 37- 872-888
SILVER 007440-22-4
010453 GAUL LE AND AN STAUD 1935 CLINICAL SPECTROSCOPY. SEVENTY CASES OF GENERALIZED ARGYRIA FOLLOWING ORGANIC AND COLLOIDAL SILVER
MEDICATION. J AM MED ASSOC. 104- 1387-1390.
BLUHBERG H AND TN CAREY 1934 ARGYREMIA DETECTION OF UNSUSPECTED AND OBSCURE ARGYRIA BY THE SPECTROGRAPHIC DEMONSTRATION OF HIGH BLOOD
SILVER J AM MED ASSOC 103. 1521-1524
EAST BW. K BOODY. ED WILLIAMS, D MACINTYRE AND ALC MCLAY 1980. SILVER RETENTION. TOTAL BODY SILVER AND TISSUE SILVER CONCENTRATIONS IN
ARGYRIA ASSOCIATED WITH EXPOSURE TO AN ANTI-SMOKING REMEDY CONTAINING SILVER ACETATE. CLIN EXP DERMATOL 5 305-311
SILVER CYANIDE 000506-64-9
010283 HOWARD JW AND RF HANZAL 1955 CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM 3- 325-329
PHILBRICK DJ, JB HOPKINS, DC HILL. JC ALEXANDER AND RG THOMSON. 1979 EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS J
TOXICOL ENVIRON HEALTH. 5: 579-592.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR SODIUM CYANIDE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. OFFICE OF
EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA 1985 RfD/RfC WORK GROUP.
SIHAZINE 000122-34-9
010955 CIBA-GEIGY CORP 1988 MRID NO 40614405, HED DOCUMENT NO 007240. 007449 AVAILABLE FROM EPA WRITE TO FOI, EPA. WASHINGTON. DC 20460.
US EPA 1991. RfD/RfC WORK GROUP
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(OTHER THAN CARCINOGEN1CITY) July 1997
SODIUM CYANIDE 000143-33-9
005640 HOWARD. JW AND RF HANZAL. 1955 CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. J AGRIC FOOD CHEM. 3' 325-329.CITED IN
US EPA. 1985
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR SODIUM CYANIDE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. OFFICE OF
EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA 1985 INTEGRATED RISK INFORMATION SYSTEM (IRIS). REFERENCE DOSE (RFD) FOR ORAL EXPOSURE FOR SODIUM CYANIDE. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH
US EPA 1985 RfD/RfC WORK GROUP.
SODIUM OIETHYLOITHIOCARBAMATE 000148-18-5
005644 SUNDERMAN. FW. OE PAYNTER AND RB GEORGE 1967 THE EFFECTS OF THE PROTRACTED ADMINISTRATION OF THE CHELATING AGENT. SODIUM
DIETHYLDITHIOCARBAMATE (DITHIOCARB) AM J MED SCI. 254 46-56.
US EPA 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SODIUM DIETHYLDITHIOCARBAMATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC
US EPA. 1985. RfD/RfC WORK GROUP.
SODIUM METAVANADATE 013718-26-8
005735 DOMINGO. JL. JL LLOBET. JM TOMAS AND J CORBELLA. 1985 SHORT-TERM TOXICITY STUDIES OF VANADIUM IN RATS J APPL TOXICOL. 5(6)- 418-421
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR VANADIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
STRONTIUM. STABLE 007440-24-6
010842 STOREY E 1961. STRONTIUM 'RICKETS' BONE CALCIUM AND STRONTIUM CHANGES AUSTRAL ANN MED. 10. 2132-222
SKORYNA SC 1981 EFFECTS OF ORAL SUPPLEMENTATION WITH STABLE STRONTIUM. CAN MED ASSOC J 125 703-712
MARIE PJ. MT GARBA. M HOTT AND L MIRAVET. 1985 EFFECT OF LOW DOSES OF STABLE STRONTIUM ON BONE METABOLISM IN RATS MINER ELECTROLYTE
METAB 11 5-13.
US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR STABLE STRONTIUM PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
US EPA 1992 RfD/RfC WORK GROUP
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(OTHER THAN CARCINOGEN1CITY) July 1997
STRYCHNINE 000057-24-9
SEIDL I AND G ZBINDEN, 1982. ORAL TOXICITY OF STRYCHNINE IN RATS. ARCH TOXICOL 51(3) 267-271
US EPA. 1985 RfD/RfC WORK GROUP.
STYRENE 000100-42-5
010059 QUASI JF. CG HUMISTON. RT KALNINS. ET AL 1979 RESULTS OF A TOXICITY STUDY OF MONOMERIC STYRENE ADMINISTERED TO BEAGLE DOGS BY ORAL
INTUBATION FOR 19 MONTHS TOXICOLOGY RESEARCH LABORATORY, HEALTH AND ENVIRONMENTAL SCIENCES. DOW CHEMICAL CO , MIDLAND, MI FINAL REPORT
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STYRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC
US EPA 1985 RfD/RfC WORK GROUP.
010511 MUTT! A, A MAZZUCCHI, P RUSTICHELLI. G FRIZERI. G ARFINI. I FRANCHINI. 1984 EXPOSURE EFFECT AND EXPOSURE RESPONSE THE RELATIONSHIP
BETWEEN OCCUPATIONAL EXPOSURE TO STYRENE AND NEUROPSYCHOLOGICAL FUNCTION AMER J IND MED 5 275-286.
US EPA 1992 RfD/RfC WORK GROUP.
SUCCINONITRILE 000110-61-2
005585 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES PREPARED 8Y THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
SULFUR DIOXIDE 007446-09-5
010505 REFER TO APPENDIX A TECHNICAL INFORMATION. SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
SULFUR OXIDES
010035 US EPA. 1987. AIR QUALITY CRITERIA FOR PARTICULATE MATTER AND SULFUR OXIDES. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. RESEARCH
TRIANGLE PARK. NC EPA 600/8-82-029F NTIS PB84-156777
SULFURIC ACID 007664-93-9
005647 CARSON, BL. BL HERNDON, HV ELLIS III. ET AL 1981. SULFURIC ACID HEALTH EFFECTS. PREPARED UNDER CONTRACT 68-03-2928 8Y MIDWEST RESEARCH
INSTITUTE, KANSAS CITY, MO PREPARED FOR EMISSION CONTROL TECHNOLOGY DIVISION, OFFICE OF MOBILE SOURCE AIR POLLUTION CONTROL US EPA, ANN
ARBOR, MI. EPA 460/3-81-025. NTIS PB82-113135,
US EPA 1984. HEALTH EFFECTS ASSESSMENT FOR SULFURIC ACID. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH. OFFICE OF
EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
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(OTHER THAN CARCINOGENICITY) July 1997
TEMEPHOS 003383-96-8
010060 GAINES TB. RD KIMBROUGH AND ER LAW, JR. 1967 TOXICOLOGY OF ABATE IN LABORATORY ANIMALS. ARCH ENVIRON HEALTH. 14: 283-288
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEMEPHOS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC
TERBUFOS 013071-79-9
010408 MORGAREIDGE K, S SISTNER. M DANIELS ET AL. 1973 FINAL REPORT: SIX-MONTH FEEDING STUDY IN DOGS ON AC-92.100 LABORATORY NO. 1193
FEBRUARY 14. UNPUBLISHED STUDY FOOD AND DRUG LABORATORIES. INC. MRID NO. 41139 AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC
20460.
US EPA. 1987. HEALTH ASSESSMENT DOCUMENT FOR TERBUFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
TEREPHTHALIC ACID 000100-21-0
010474 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEREPHTHALIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC
TETRACHLOROAZOXYBENZENE 021232-47-3
010064 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB. TCAOB AND TCHB PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
TETRACHLOROBENZENE, 1.2,4,5- 000095-94-3
010286 CHU I, DC VILLENEUVE. VE VALLI AND VE SECOURS. 1984 TOXICITY OF 1,2.3,4-. 1.2,3,5- AND 1,2.4,5-TETRACHLOROBENZENE IN THE RAT- RESULTS OF
A 90-DAY FEEDING STUDY. DRUG CHEM TOXICOL 7- 113-127
US EPA 1985 RfD/RfC WORK GROUP.
TETRACHLOROCYCLOPENTADIENE 000695-77-2
005303 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
TETRACHLOROETHANE, 1.1.1.2- 000630-20-6
010407 NTP (NATIONAL TOXICOLOGY PROGRAM) 1983. CARCINOGENESIS STUDIES OF 1.1.1.2-TETRACHLOROETHANE IN F344/N RATS AND B6C3F1MICE NTP.
WASHINGTON. DC.
US EPA 1987. RfD/RfC WORK GROUP.
US EPA. 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR TETRACHLOROETHANE. 1.1.1.2- PREPARED BY THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICL OF WATER.
WASHINGTON. DC
TETRACHLOROETHYLENE 000127-18-4
005650 BUBEN, JA AND EJ O'FLAHERTY. 1985. DELINEATION OF THE ROLE OF METABOLISM IN THE HEPATOXICITY OF TRICHLOROETHYLENE AND PERCHLOROETHYLENE:
A DOSE-EFFECT STUDY TOXICOL APPL PHARMACOL 78: 105-122
US EPA 1987. RfD/RfC WORK GROUP
TETRACHLOROHYDRAZOBENZENE 071753-42-9
010065 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB. TCAOB AND TCHB PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
TETRACHLOROPHENOL. 2,3,4,5- 004901-51-3
005324 US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.
TETRACHLOROPHENOL, 2,3,4,6- 000058-90-2
005323 US EPA. 1986 2.3.4.6-TETRACHLOROPHENOL. 90-DAY SUBCHRONIC ORAL TOXICITY STUDY IN RATS OFFICE OF SOLID WASTE. WASHINGTON. DC
TETRACHLOROPHENOL. 2,3.5.6- 000935-95-5
005325 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.
US EPA. 1987 RfD/RfC WORK GROUP
TETRACHLOROPROPENE, 1.1.2.3- 010436-39-2
010066 US EPA 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCIKOGENICITY) July 1997
TETRACHLOROVINPHOS / (STIROPHQS) 000961-11-5
01006? SHELL CHEHICAL COMPANY 1968. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 115684
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROFOS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC.
US EPA 1986. RfO/RfC WORK GROUP
TETRAETHYL DITHIOPYRQPHOSPHATE 003689-24-5
010287 KIMMERLE G AND OR KLIMMER. 1974. ACUTE AND SUBCHRONIC TOXICITY OF SULFOTEP ARCH TOXICOL. 33(1)- 1-16.
US EPA. 1988. RfQ/RfC WORK GROUP.
THALLIC OXIDE 001314-32-5
010956 US EPA. 1993. RfO/RfC WORK GROUP.
THALLIUM (I) ACETATE 000563-68-8
005664 US EPA 1986 SUBCHRONIC (90 DAY) TOXI.CITY OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
US EPA 1988 RfD/RfC WORK
THALLIUM (I) CARBONATE 006533-73-9
005668 US EPA 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS FINAL REPORT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1988, HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
US EPA. 1988 RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
July 1997
THALLIUM (I) CHLORIDE 007791-12-0
005672 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
FINAL REPORT ENVIRONMENTAL
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA 1988 RfD/RfC WORK GROUP.
THALLIUM (I) NITRATE 010102-45-1
005676 US EPA 1986 SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
FINAL REPORT ENVIRONMENTAL
US EPA. 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA 1988 RfD/RfC WORK GROUP
THALLIUM (I) SULFATE 007446-18-6
005682 US EPA 1986 SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CA NO 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA 1988 RfD/RfC WORK GROUP.
THALLIUM (IN SOLUBLE SALTS)
010458 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
THALLIUM SELENITE
010957 US EPA
012039-52-0
1993 RfD/RfC WORK GROUP.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
THIOCYANOMETHYLTHIO)BENZOTHIAZOLE, 2-( 021564-17-0
010068 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCMTB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
THIOFANOX 013196-18-4
010069 US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THIOFANOX PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
THIRAM 000137-26-8
010459 E I. DU PONT DE NEMOURS AND COMPANY, INC. 1954. MRID NO 0045162. AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460
US EPA. 1987 RfD/RfC WORK GROUP.
010070 HORNSHAW TC. RJ AULERICH AND RK RINGER. 1987 TOXICITY OF THIRAM (TETRAMETHYLTHINORAM DISULFIDE) TO MINK AND EUROPEAN FERRETS BULL
ENVIRON CONTAM TOXICOL 38(4)- 618-626
US EPA. 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THIRAM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
TIN AND COMPOUNDS
005688 NTP (NATIONAL TOXICOLOGY PROGRAM) 1982 CARCINOGENESIS BIOASSAY OF STANNOUS CHLORIDE (CAS NO 7772-99-8) IN F344/N RATS AND B6C3F1/N MICE
(FEED STUDY). NCI/NTP TECH REP SER NO 231. ALSO PUBL AS DHHS (NIH) PUBL ISS NIH 82-1787 AND NTIS PB 82-242-553.
US EPA 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (1) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS FINAL REPORT
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR TIN ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGEN!CITY) July 1997
TOLUENE 000108-88-3
010469 NTP (NATIONAL TOXICOLOGY PROGRAM). 1989, TOXICOLOGY AND CARCINOGENESIS STUDIES OF TOLUENE IN F344 RATS AND B6C3F1 MICE. TECHNICAL REPORT
SERIES NO 371
US EPA, 1984. HEALTH EFFECTS ASSESSMENT FOR TOLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC.
US EPA 1990. RfD/RfC WORK GROUP
010844 FOO S. J JEYARATHAM AND D KOH. 1990, CHRONIC NEURQ8EHAVIORAL EFFECTS OF TOLUENE. BR J INO MED. 47(7)- 480-484,
NTP (NATIONAL TOXICOLOGY PROGRAM). 1990 TOXICOLOGY AND CARCINOGENESIS STUDIES OF TOLUENE IN F344/N RATS AND B6C3F1 MICE (INHALATION
STUDIES). NTP TR 371 253 P
US EPA 1991 RfD/RfC WORK
TOLUENE-2.5-DIAMINE 000095-70-5
010073 NCI (NATIONAL CANCER INSTITUTE) 1978 BIOASSAY OF TOLUENE-2.5-DIAMINE SULFATE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP
SER NO 126
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC
TOLUENE-2.6-DIAMINE 000823-40-5
010074 NCI (NATIONAL INSTITUTE) 1980 BIOASSAY OF 2,6-TOLUENEDIAMINE DIHYDROCHLORIOE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS
TECH REP SER NO 200
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC
TOLUENEDIAMINE. 2,3- 002687-25-4
010071 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TQLUENEDIAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
TOLUENEDIAHINE, 3,4- 000496-72-0
010072 US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SELECTED TOLUENEDIAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCIN06ENICITY) July 1997
TOLUIDINE, M- 000108-44-1
010075 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TQLUIDINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC.
TRIALLATE 002303-17-5
010076 MONSANTO COMPANY. 1979. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY ACCESSION NO 242057.
US EPA 1986 RfD/RfC WORK GROUP
TRIBROMOBENZENE, 1,2,4- 000615-54-3
010077 CARLSON SP AND R6 TARDIFF. 1977 EFFECT OF 1,4-DIBROMOOIBENZENE AND 1.2.4-TRIBROMOBENZENE ON XENOBIOTIC METABOLISM. TOXICOL APPL
PHARMACOL. 42. 189496.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC,
US EPA. 1986. RfD/RfC WORK GROUP
TRICHLORO-1.2.2-TRIFLUOROETHANE. 1.1,2- 000076-13-1
010460 INBUS HR AND C ATKINS 1972 PHYSICAL EXAMINATION OF WORKERS EXPOSED TO TRICHLORQTRIFLUOROETHANE. ARCH ENVIRON HEALTH. 24(4): 257-261
010376 TRACHIMQWICZ HJ. GM RUSCH, T CHIU. ET AL. 1988 CHRONIC INHALATION TQXICITY/CARCINOGENICITY STUDY IN RATS EXPOSED TO FLUOROCARBON 113
(FC-113) FUND APPL TOXICOL. 11(1)- 68-75.
US EPA 1990 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.1.2-TRICHLORO-1.2.2-TRIFLUOROETHANE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC.
TRICHLORO-2'-HYDROXYDIPHENYLETHER, 2,2,4'- 003380-34-5
005492 LYMAN, FL AND T FURIA. 1969. TOXICOLOGY OF 2,4.4'-TRJCHLORO-2'-HYDROXYDIPHENYL ETHER. IND MED. 38: 45-52.
US EPA 1987 HEALTH EFFECTS AND ENVIRONMENTAL DOCUMENT FOR HALOETHERS ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH,
OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
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(OTHER THAN CARCINOGENICITY) July 1997
TRICHLOROBENZENE, 1,2,4- 000120-82-1
010506 ROBINSON, KS, RJ KAVLOCK, N CHERNOFF AND E GRAY 1981 MULTIGENERATION STUDY OF TRICHLOROBENZENE IN RATS, J TOXICOL ENVIRON. HEALTH. 8
489-500
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR 1,2.4-TRICHLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON, DC,
010958 KOCIBA RJ. BKL LEONG, RE HEFNER. JR. 1981 SUBCHRONIC TOXICITY STUDY OF 1,2.4-TRICHLOROBENZENE IN THE RAT. RABBIT AND BEAGLE DOG. DRUG
AND CHEMICAL TOXICOLOGY 4(3)- 229-249.
COATE WB, TR LEWIS, WM BUSEY 1977. CHRONIC INHALATION EXPOSURE OF RATS, RABBITS AND MONKEYS TO 1.2,4-TRICHLOROBENZENE ARCHIVES OF
ENVIRONMENTAL HEALTH. 32(6) 249-255
COTE M, I CHU, DC VELLENEUVE, VE SECOURS, VE VALLI 1988. TRICHLOROBENZENES: RESULTS OF A THIRTEEN WEEK FEEDING STUDY IN THE RAT DRUG
AND CHEMICAL TOXICOLOGY 11(1)- 11-28.
US EPA. 1993. RfD/RfC WORK GROUP.
TRICHLOROCYCLOPENTADIENE 077323-84-3
005304 US EPA. 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC.
TRICHLOROETHANE, 1,1,2- 000079-00-5
005702 WHITE, KL JR. VM SANDERS, VW BARNES, GM SHOPP AND AE MUNSON. 1985 TOXICOLOGY OF 1,1,2 TRICHLOROETHANE IN THE MOUSE DRUG CHEM TOXICOL.
8(5): 333-355.
SANDERS, VM, KL WHITE JR, 6M SHOPP JR AND AE MUNSON 1985 HUMORAL AND CELL MEDIATED IMMUNE STATUS OF MICE EXPOSED TO 1,1.2
TRICHLOROETHANE DRUG CHEM TOXICOL 8(5) 357-372
US EPA 1990 RfD/RfC WORK GROUP
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(OTHER THAN CARCINOGEN1CITY) July 1997
TRICHLOROFLUOROMETHANE 000075-69-4
NCI (NATIONAL INSTITUTE) 1978. BIQASSAY OF TRICHLOROFLUORGMETHANE FOR POSSIBLE CARCINOGENICITY, NCI CARCINOGENESIS TECH REP SER
NO 106, ALSO PUBL AS DHEW (NIH) 78-1356
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA. 1985 RfO/RfC WORK GROUP.
005500 NCI (NATIONAL CANCER INSTITUTE) 1978 BIOASSAY OF TRICHLOROFLUOROMETHANE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER
NO 106. ALSO PUSL AS OHEW (NIH) 78-1356
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATEO METHANES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH
OFFICE OF AND REMEDIAL RESPONSE. WASHINGTON. DC
TRICHLOROPHENOL, 2,3,4- . 015950-66-0
005330 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
TRICHLOROPHENOL, 2,3,5- 000933-78-8
005331 US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
TRICHLOROPHENOL, 2,3,6- 000933-75-5
005332 US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
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(OTHER THAN CARCIN06ENICITY) July 1997
TRICHLOROPHENOL, 2,4,5- 000095-95-4
005329 MCCOLLISTER. DO. DT LOCKWOOD AND VK ROWE 1961 TOXICOLOGIC INFORMATION ON 2.4.5-TRICHLOROPHENOL TOXICOL APPL PHARMACOL 3 63-70,
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR 2,4.5-TRICHLOROPHENOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCV RESPONSE.
WASHINGTON, DC.
US EPA 1985. RfD/RfC WORK
010919 US EPA. 1991. RfD/RfC WORK GROUP.
TRICHLOROPHENOL, 2,4,6- 000088-06-2
010461 US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
US EPA. 1991. RfD/RfC WORK GROUP.
TRICHLOROPHENOL, 3,4,5- 000609-19-8
005333 US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
TRICHLOROPHENOXY) PROPIONIC ACID, 2(2,4,5- 000093-72-1
010284 GEHRING PJ AND JE BETSO 1978 PHENOXY ACIDS: EFFECTS AND FATE IN MAMMALS IN. CHLORINATED PHENOXY ACIDS AND THEIR OIOXINS.VOL 27 C
RAMEL ED ECOL BULL. STOCKHOLM. P, 122-133
MULLISON WR 1966. SOME TOXICOLOGICAL ASPECTS OF SILVEX IN: PROC 19TH ANN MEET SOUTHERN WEED CONFERENCE, JACKSONVILLE. FL. P 420-435.
US EPA. 1988 RfD/RfC WORK GROUP
Rl-S
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
TRICHLOROPHENOXYACETIC ACID, 2,4,5- 000093-76-5
010178 KOCIBA. RS. DG KEYES. RW LISOWE. ET AL 1979. RESULTS OF 2-YEAR CHRONIC TOXICITY AND ONCOGENICITY STUDY OF RATS INGESTING DIETS
CONTAINING 2.4.5-T. FOOD COSMET TOXICOL 17: 205 -222.
SMITH FA. FJ MURRAY, JA JOHN. ET AL. 1981 THREE-GENERATION REPRODUCTION STUDY OF RATS INGESTING 2.4.5-TRICHLOROPHENOXYACETIC ACID IN THE
DIET TOXICO RES LAB.. DOW CHEMICAL. MIDLAND. MI.
US EPA. 1989. HEALTH EFFECTS ASSESSMENT FOR 2.4.5-TRICHLOROPHENOXY ACETIC ACID PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
DC
US EPA 1988 RfD/RfC WORK GROUP
010179 GEHRING. PJ. AND JE BETSO. 1978 PHENOXY ACIDS. EFFECTS AND FATE IN MAMMALS. ECO BULL 27 122-123
US EPA 1989 HEALTH EFFECTS ASSESSMENT FOR 2.4.5-TRICHLOROPHENOXY ACETIC ACID PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
DC
TRICHLOROPROPANE. 1.1.1- 007789-89-1
005705 US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.
OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
TRICHLOROPROPANE, 1.1,2- 000598-77-6
005708 VILLANEUVE. DC. I CHU. VE SECOURS. MG COTIE. GL PLAA AND VE VALLI 19S5 RESULTS OF A 90-DAY TOXICITY STUDY ON 1.2.3- AND
1.1.2-TRICHLOROPROPANE ADMINISTERED VIA THE DRINKING WATER SCI TOTAL ENVIRON 47- 421-426
US EPA. 1987. RfD/RfC WORK GROUP.
TRICHLOROPROPANE. 1,2,2- 003175-23-3
005706 US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI.
OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
Rl-99
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARGINOGENICITY) July 1997
TRICHLOROPROPANE. 1,2.3- 000096-18-4
OOS714 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983 FINAL REPORT 120-DAY TOXICITY GAVAfiE STUDY OF 1.2.3-TRICHLOROPROPANE IN FISCHER 344 RATS.
PERFORMED BY HAZELTQN LABORATORIES.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI,
OH. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA. 1986 RfD/RfC WORK GROUP
TRICHLOROPROPENE, 1,2,3- 000096-19-5
010078 MCKENNA MJ. JF QUAST AND GA STEVENS. 1978. RESULTS OF A90-DAY INHALATION TOXICITY STUDY OF 1,2.3-TRICHLOROPROPENE IN LABORATORY ANIMALS
TOXICOL APPL PHARMACOL. 45: 249.
US EPA. 1983 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC.
TRICHLOROTOLUENE. 2,3,6- 002077-46-5
005335 CHU I. SY SHEN. DC VILLENEUVE, VE SECOURS AND VE VALLI 1984. TOXICITY OF TRICHLOROTOLUENE ISOMERS. A 28-DAY FEEDING STUDY IN THE RAT J
ENVIRON SCI HEALTH PART B PESTIC FOOD CONTAM AGRIC WASTES. 19(2): 183-192
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED TOLUENES. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
TRICHLOROTOLUENE, ALPHA,2,6- 002014-83-7
005339 CHU I. SY SHEN, DC VILLENEUVE. VE SECOURS AND VE VALLI 1984 TOXICITY OF TRICHLOROTOLUENE ISOMERS. A 28-DAY FEEDING STUDY IN THE RAT. J
ENVIRON SCI HEALTH PART B PESTIC FOOD CONTAM AGRIC WASTES 19(2): 183-192
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED TOLUENES ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,
CINCINNATI. OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
Rl-100
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
TRIFLURALIN 001582-09-8
010080 HOECHST AKTIENGESELLSCHAFT 1984. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY MRID NO 00151908 AVAILABLE FROM EPA WRITE TO
FOI. EPA. WASHINGTON. DC 20460.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC
US EPA 1989 RfO/RfC WORK GROUP.
US EPA. 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR TRIFLURALIN. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF WATER. WASHINGTON. DC
TRIMETHYL8ENZENES
005727 US EPA. 1987 HEALTH AND ENVIRONMENTAL ASSESSMENT FOR TRIMETHYLBENZENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENT ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
TRINITROBENZENE, 1,3,5- 000099-35-4
010081 CODY TE, S WITHERUP. L HASTINGS. K STEMMER AND RT CHUSTION. 1981 1.3-DINITROBENZENE: TOXIC EFFECTS IN VITRO. J TOXICOL ENVIRON HEALTH.
7: 829-847
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3,5-TRINITROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1988 RfD/RfC WORK GROUP.
TRINITROPHENOLS
010082 US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRINITROPHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON. DC.
TRINITROPHENYLMETHYLNITRAMINE 000479-45-8
010377 FATI S. E DANIELE. 1965 HISTOPATHOLOGICAL CHANGES IN EXPERIMENTAL CHRONIC TETRYL POISONING. FOLIA MED 48(4) 260-276.
US EPA 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRINITROPHENYLMETHYLNITRAMINE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
TRINITROTOLUENE, 2,4,6- 000118-96-7
010416 US DOO (DEPARTMENT OF DEFENSE) 1983. AO-A157-002. DEFENSE TECHNICAL CENTER, CAMERON STATION, ALEXANDRIA. VA
US EPA 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2.4,6-TRINITRQTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON
DC
US EPA 1988. RfD/RfC WORK GROUP
VANADIUM 007440-62-2
005739 SCHROEOER, HA, M MITCHENER AND AP 1970, ZIRCONIUM, NIOBIUM, ANTIMONY AND LEAD IN RATS LIFE-TIME STUDIES J NUTR 100 59-69
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR VANADIUM AND COMPOUNDS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
VANADIUM PENTOXIDE 001314-62-1
005743 STOKINGER, HE, WO WAGNER. JT MOUNTAIN ET AL 1953. UNPUBLISHED RESULTS. DIV OCCUP HEALTH, CINCINNATI. OH CITED IN STDKINGER. 1981
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR VANADIUM AND COMPOUNDS, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1986. RfD/RfC WORK GROUP.
VANADIUM SULFATE 036907-42-3
005747 SCHROEDER. HA. K MITCHENER AND AP NASON. 1970 ZIRCONIUM, NIOBIUM. ANTIMONY AND LEAD IN RATS LIFE-TIME STUDIES. J NUTR 100 59-69
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
" ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
VERNAM / (VERNOLATE) 001929-77-7
010083 STAUFFER CHEMICAL COMPANY 1983 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY ACCESSION NOS 249703-249704
US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR VERNOLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC.
US EPA. 1986. RfD/RfC WORK GROUP
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
VINYL ACETATE 000108-05-4
010417 SHAW DC. 1988, VINYL ACETATE: 104-WEEK ORAL (DRINKING WATER) TOXICITY AND CARCINOGENICITY STUDY IN THE RAT FOLLOWING IN
VITRO EXPOSURE, VOLUME I. HAZELETON LABORATORIES, UK. REPORT NO. 5531-5/16 EPA DOC. NO. 86-0000265. FICHE NO OTS0514156
US EPA 1989 HEALTH AMD ENVIRONMENTAL EFFECTS DOCUMENT FOR VINYL ACETATE, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC.
010418 OWEN. PE. 1988. VINYL ACETATE 104 WEEK INHALATION COMBINED CHRONIC TOXICITY AND CARCINOGENICITY STUDY IN THE RAT AND MOUSE. REPORT
PREPARED BY HAZELTON LABORATORIES EUROPE. LTD . HARROGATE. ENGLAND FOR THE SOCIETY OF THE PLASTICS INDUSTRY, INC , NEW YORK REPORT NO.
5547-51/15. NOVEMBER. 1988
SEEMS. RB 1988. REPORT NO V88-133- HISTOPATHQLOGY OF THE RESPIRATORY TRACT OF MICE USED IN A 104-WEEK INHALATION STUDY (OWEN. 1988) WITH
VINYL ACETATE (TNO-CIVO INSTITUTES. APRIL, 1988)
DREEF. VAN DER MEULEN. HC 1988. REPORT NO V88. 033/270836: HISTOPATHOLOGY OF THE RESPIRATORY TRACT OF RATS USED IN A 104 WEEK
INHALATION STUDY (OWEN, 1988) WITH VINYL ACETATE: REVISED VERSION (TNO-CIVQ INSTITUTES. OCTOBER. 1988).
US EPA 1990. RfD/RfC WORK GROUP
VINYL-1-CYCLOHEXENE, 4- 000100-40-3
010084 US EPA. 1983 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-VINYL-l-CYCLOHEXENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
WARFARIN 000081-81-2
010409 HUFF, BB, ED 1985. PHYSICIANS DESK REFERENCE. 39TH EO MEDICAL ECONOMICS CO . INC.. ORADELL. NJ
US EPA 1986 RfD/RfC WORK GROUP.
XYLENE, M- 000108-38-3
005755 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS OF XYLENES (MIXED) (60 22M-XYLENE.
13.6% P-XYLENE. 17 0% ETHYLBENZENE AND 9 U 0-XYLENE) (CAS NO. 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) US DHHS. PHS.
NIH. NTP. RESEARCH TRIANGLE PARK. NC, NTP TR 327. NIH PUBL NO 86-2583
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR XYLENES (0-, M-. P-) ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
010920 US EPA 1991. RfD/RfC WORK
Rl-103
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
XYLENE, MIXTURE 001330-20-7
010872 NTP (NATIONAL TOXICOLOGY PROGRAM) 1986 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS OF XYLENES (MIXED) (60.2W-XYLENE.
13 61 P-XYLENE, 17 OX ETHYLBENZENE AND 9 131 0-XYLENE) (CAS NO 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). US DHHS, PHS,
NIH, NTP, RESEARCH TRIANGLE PARK, NC. NTP TR 327, NIH PU8L NO 86-2583
US EPA. 1989 UPDATED HEALTH EFFECTS ASSESSMENT FOR XYLENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH, FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA. 1987. RfD WORK GROUP.
010921 US EPA 1991 RfO/RfC WORK
XYLENE, 0- 000095-47-6
005751 NTP (NATIONAL TOXICOLOGY PROGRAM) 1986 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS OF XYLENES (MIXED) (60.2% M-XYLENE.
13 61 P-XYLENE, 17.01 ETHYLBENZENE AND 9 II 0-XYLENE) (CAS NO 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) US OHHS, PHS.
NIH, NTP. RESEARCH TRIANGLE PARK, NC, NTP TR 327, NIH PUBL NO 86-2583.
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR XYLENES (0-. K-. P-) ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
010922 US EPA 1991. RfD/RfC WORK GROUP.
XYLENE, P- 000106-42-3
010923 US EPA 1991 RfD/RfC WORK GROUP.
ZINC (METALLIC) 007440-66-6
010937 YAQR1CK, MF. MA KENNEY AND EA W1NTERFELDT 1989. IRON. COPPER AND ZINC STATUS RESPONSE TO SUPPLEMENTATION WITH ZINC OR ZINC AND [RON [N
ADULT FEMALES. AM J CLIN NUTR 49 145-150
US EPA 1991 RfD/RfC WORK GROUP
ZINC CYANIDE 000557-21-1
010289 HOWARD JW AND RF HANZAL. 1955 CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE AGRIC FOOD CHEM. 3. 325-329.
PHILBRICK DJ, JB HOPKINS, DC HILL. JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING IN RATS J
TOXICOL ENVIRON HEALTH 5- 579-592
US EPA 1985. RfD/RfC WORK GROUP,
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ZINC PHOSPHIDE 001314-84-7
010290 BAI KM. MK KRISHNAKUMARI. JP RAMESH, T SHIVANANDAPPA AND SK MAJUNDER 1980. SHORT-TERM TOXICITY STUDY OF ZINC PHOSPHIDE IN ALBINO RATS
INDIAN J EXPTL BIOL. 18' 854-857.
US EPA. 1986 RfD/RfC WORK GROUP.
ZINEB 012122-67-7
010085 BLACKWELL-SMITH RJ JR. JK FINNEGAN, PS LARSON, ET AL. 1953 TOXICOLOGIC STUDIES ON ZINC AND DISODIUM ETHYLENE BISDITHIOCARBAMATES. J
PHARMACOL EXP THER 109 159-166
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ZINEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON. DC.
US EPA 1986 RfD/RfC WORK GROUP
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DOSE
ROUTE
ACETONE CYANOHYDRIN
NOEL 4 0 HG/KG/DAY
INHALATION:
INTERMITTENT
HEAST TABLE 2:
EXPERIMENT LENGTH TARGET
000075-86-5
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
July 1997
CRITICAL EFFECT
RAT
14 WEEKS
CENTRAL NERVOUS EFFECTS
SYSTEM
Subchrom c
[RfC] [RfD]
(rro/cu m) (mq/kg/day)
UF UF
1E-1
100
Chronic
[RfC] [RfO] REFERENCE
(mq/cu m). (im/kg/day)
UF UF
1E-2
1000
010432
SUBCHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). AN ERROR IN THE UNCERTAINTY FACTOR THAT WAS
REPORTED IN HEED (1988) WAS CORRECTED,
CHRONIC [RfC] COMMENT 4E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT- THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT 'IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfO/RfC WORK GROUP ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
ACETONITRILE
NOAEL 100 PPM
INHALATION
INTERMITTENT
000075-05-8
MOUSE
92 DAYS LIVER
INCREASED RELATIVE WEIGHT
5E-1
300
5E-2
3000
005208
SUBCHRONIC [RfC] COMMENT: 1E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT, 1E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST). UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE,
GENERAL COMMENT, THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
BARIUM
NOEL 0.8 MG/CU M
INHALATION,
INTERMITTENT
007440-39-3
RAT
4 MONTHS
FETUS
FETOTOXICITY
5E-3
100
5E-4
1000
005249
SUBCHRONIC [RfC] COMMENT- 1E~3 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST) BASED ON A REPRODUCTION STUDY
CHRONIC [RfC] COMMENT- 1E-4 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). BASED ON A REPRODUCTION STUDY
GENERAL COMMENT THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP ALSO SEE TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
2-1
-------
HEAST TABLE 2:
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
July 1997
CHEMICAL
LEVEL
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu Hi), (mq/kq/dav) (ro/cu m) (mq/kg/dav)
UF UF UF UF
CHLORO-1.3-BUTADIENE ,
NOAEL 10 PPH
INHALATION-
INTERMITTENT
(CHLOROPRENE)
RAT
2 YEARS
HAIR
WHOLE BODY
000126-99-8
ALOPECIA
DECREASED WEIGHT GAIN
2E-2
100
2E-2
100
005878
SUBCHRONIC [RfD] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION ASSUMING AN INHALATION ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION ASSUMING AN INHALATION ABSORPTION FACTOR OF 0 5.
GENERAL COMMENT: SEE ALSO HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLOROBENZENE
LOAEL 75 PPM
INHALATION.
INTERMITTENT
000108-90-7
RAT
120 DAYS
LIVER
KIDNEY
EFFECTS
EFFECTS
2E-2
-
005353
CHRONIC [RfC] COMMENT 5E-3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST), UNDER REVIEW. CURRENT SUBJECT TO CHANGE.
GENERAL COMMENT- THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK ALSO SEE TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY.
CYCLOPENTADIENE
NOEL 87 3 MG/KG/DAY
INHALATION
INTERMITTENT
000542-92-7
RAT
194 DAYS
LIVER
KIDNEY
LESIONS
LESIONS
3E+0
100
005401
SUBCHRONIC [RfC] COMMENT: 9E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT THE SUBCHRONIC INHALATION [RfC] VALUE WAS DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM INHALATION
METHODOLOGY USED BY THE RfD/RfC WORK GROUP.
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
2-2
-------
DOSE
ROUTE
HEAST TABLE 2:
EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINQGENICITY)
July 1997
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(mg/cu m) (mq/kg/jay)
UF UF
Chronic
[RfC] [RfD]
(mq/curo) (mo/kg/day)
UF UF
REFERENCE
DICHLOROBENZENE. 1,2-
NOEL 49 PPM RAT
INHALATION: UP TO 7
INTERMITTENT HONTHS
000095-50-1
WHOLE BODY
DECREASED WEIGHT GAIN
2E+0
100
2E~1
1000
005412
CHRONIC [RfC] COMMENT, 4E~2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP, ALSO SEE TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY
DICHLORODIFLUOROMETHANE
LOAEL 482.3 MG/KG/DAY
INHALATION
INTERMITTENT
000075-71-8
GUINEA PIG
6 WEEKS LIVER
LESIONS
2E+0
1000
005497
10000
SUBCHRONIC [RfC] COMMENT: 5E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT 5E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT- THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP- ALSO SEE TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY
DICHLOROETHANE. 1.1-
NOEL 138 MG/KG/DAY
INHALATION
INTERMITTENT
000075-34-3
CAT
13 WEEKS KIDNEY
DAMAGE
5E+0
100
5E-1
1000
005789
SUBCHRONIC [RfC] COMMENT: 1E+0 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT 1E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE HEAST TABLE 1. CHRONIC AND SUBCHRONIC TOXICITY AND
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. !S UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
2-3
-------
HEAST TABLE 2:
DOSE SPECIES
EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
July 1997
CRITICAL EFFECT
Subchronic
[RfC] [RfO]
(mg/cum) (mq/kq/dav)
UP UF
Chronic
[RfC] [RfD]
(mq/cu m) (im/kg/dav)
UF UF
REFERENCE
DICYCLOPENTADIENE
LOAEL 1 PPM
INHALATION:
INTERMITTENT
000077-73-6
RAT
90 DAYS
KIDNEY
DYSFUNCTION
2E-3
1000
2E-4
10000
005424
SUBCHRONIC [RfC] COMMENT: 6E-4 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT. 6E-5 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST)
GENERAL COMMENT THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY.
ETHOXYETHANQL ACETATE, 2- 000111-15-9
NOEL 30.1 MG/KG/DAY RAT
INHALATION- DAY 6-18 OF FETUS
INTERMITTENT GESTATION
DECREASED OSSIFICATION
3E-1
100
3E-1
100
005952
[RfD] COMMENT- ON TO EXTRAPOLATION. THE SUBCHRONIC ORAL [RfD]WAS ON A REPRODUCTION STUDY WITH
EXPOSURES DURING DAYS 6-18 OF GESTATION.
CHRONIC [RfO] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION. THE CHRONIC ORAL [RfD] WAS BASED ON A REPRODUCTION STUDY WITH EXPOSURES
DURING DAYS 6-18 OF GESTATION
GENERAL COMMENT- NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY TO EXTRAPOLATION FOR THE ORAL [RfD] VALUES ALSO SEE
TABLE
1: SUBCHRONIC AND CHRONIC TOXICITY VALUES.
FURFURAL
NOAEL 20 PPM
INHALATION-
INTERMITTENT
000098-01-1
HAMSTER
13 WEEKS
NASAL CAVITY
OLFACTORY DEGENERATION
5E-1
100
5E-2
1000
005465
SUBCHRONIC [RfC] COMMENT: 1E-1 MG/KG/DAY (SEE APPENDIX A-ll. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT. 1E-2 MG/KG/DAY (SEE APPENDIX A-ll, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP ALSO SEE TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
2-4
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
(wq/cu m) (ing/kq/dav)
UF UF
Chronic
[RfC] [RfD]
(ITB/CU m) (iro/kg/dav)
UF UF
July 1997
REFERENCE
METHACRYLONITRILE
NOEL 3.2 PPM
INHALATION:
INTERMITTENT
DOG
90 DAYS
000126-98-7
LIVER
LIVER
INCREASED SGOT
INCREASED SGPT
7E-3
300
7E-4
3000
005811
SUBCHRONIC [RfC] COMMENT; 2E-3 MG/KG/OAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST), THESE VALUES DIFFER FROM THOSE IN THE 198?
HEED
CHRONIC [RfC] COMMENT 2E-4 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST) THESE VALUES DIFFER FROM THOSE IN THE 1987
HEED,
GENERAL COMMENT; THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FRQN METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY,
METHOXYETHANOL ACETATE, 2- 000110-49-6
NOAEL 10 PPM RABBIT
INHALATION 13 WEEKS TESTIS
INTERMITTENT
DEGENERATION
2E-2
100
2E-3
1000
010001
SUBCHRONIC [RfD] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION USIHG AN ABSORPTION FACTOR OF 0.5, CALCULATED FROM DATA OBTAINED WITH
METHOXYETHANOL CONVERTED BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118.13/76.09).
CHRONIC [RfD] COMMENT ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5. CALCULATED FROM DATA OBTAINED WITH
METHOXYETHANOL CONVERTED BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118.13/76 09)
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES
METHOXYETHANOL. 2-
NOAEL 31 MG/CU M
INHALATION.
INTERMITTENT
000109-86-4
RABBIT
13 WEEKS
TESTICLE
EFFECTS
1E-2
100
010910
1000
SUBCHRONIC [RfO] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION
CHRONIC [RfD] COMMENT; ON ROUTE TO EXTRAPOLATION
GENERAL COMMENT- ALSO SEE TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. ,'513) 569-7254.
2-5
-------
HEAST TABLE 2:
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
July 1997
CRITICAL EFFECT
Subchronic
[RfC] [RfO]
Cma/cu ml (p/ka/day)
UF UF
Chronic
[RfC] [RfD] REFERENCE
(inq/cy mj (ip/_kq/day_)
UF UF
METHYL ACRYLATE
NOEL 15 PPM
INHALATION:
INTERMITTENT
000096-33-3
RAT
2 YEARS
NONE OBSERVED
3E-2
100
3E-2
100
010003
SUBCHRONIC [RfD] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
METHYL ISOBUTYL KETONE
NOEL 50 PPM
INHALATION.
INTERMITTENT
RAT
90 DAYS
000108-10-1
LIVER
KIDNEY
INCREASED WEIGHT
EFFECTS
8E-1
100
8E-2
1000
005562
SUBCHRONIC [RfC] COMMENT- 2E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSION ON HEAST).
CHRONIC [RfC] COMMENT. 2E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSION ON HEAST).
GENERAL COMMENT. THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFQPMATION. RISK INFORMATION HOTLINE: (513) 569-7254,
2-6
-------
HEAST TABLE 2:
LEVEL
DOSE SPECIES
ROUTE EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
July 1997
CRITICAL EFFECT
Sutscbronic
[RfC] [RfD]
(M/CUinj (mg/kq/dav)
UF UF
Chronic
[RfC] [RfD]
(mq/cu m) dna/kq/davl
UF UF
REFERENCE
METHYL STYRENE (MIXED
LOAEL 5 6 MG/KG/DAY
INHALATION:
INTERMITTENT
ISOMERS) 025013-15-4
HOUSE
103 WEEKS
NASAL CAVITY
LESIONS
6E-3
1000
6E-3
1000
005567
SUBCHRONIC [RfD] COMMENT- ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0.5
CHRONIC [RfD] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: NO PHARHACOKINET1C DATA WERE PROVIDED TO JUSTIFY ROUTE TO EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
LOAEL 11 2 MG/KG/DAY MOUSE
INHALATION. 103 WEEKS
INTERMITTENT
NASAL CAVITY
LESIONS
4E-2
1000
4E-2
1000
005566
SUBCHRONIC [RfC] COMMENT: 1E-2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT 1E~2 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT. THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfO/RfC WORK GROUP.
METHYL STYRENE, ALPHA
NOEL 970 MG/CU M
INHALATION-
INTERMITTENT
000098-83-9
RAT
197 DAYS
LIVER
KIDNEY
INCREASED WEIGHT
INCREASED WEIGHT
7E-1
100
7E-2
1000
010016
SUBCHRONIC [RfO] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5.
CHRONIC [RfD] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0 5
GENERAL COMMENT, NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254
2-7
-------
HEAST TABLE 2:
CHEM1C
LEVEL
DOSE
ROUTE
EXPERIMENT LENGTH
TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
CRITICAL EFFECT
Subchronic
[RfC] [RfD]
Ima/cu.m) (p/ka/day)
UF UF
July 1997
Chrome
[RfC] [RfD]
(p/cy m) (mg/kg/dav)
UF UF
REFERENCE
METHYLENE BROMIDE
NOAEL 11 MG/KG/OAY
INHALATION:
INTERMITTENT
000074-95-3
RAT
90 DAYS BLOOD
INCREASED CARBOXYHEKOGLQBIN
1E-1
100
1E-2
1000
010011
SUBCHRONIC [RfO] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION, INCLUDING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfO] COMMENT- ON ROUTE TO ROUTE EXTRAPOLATION. INCLUDING AN ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
NITROBENZENE
LOAEL 25 MG/CU M
INHALATION:
INTERMITTENT
MOUSE
90 DAYS
000098-95-3
BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
2E-2
1000
2E-3
10000
010518
INHALATION.
INTERMITTENT
RAT
90 DAYS
BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
SUBCHRONIC [RfC] COMMENT. 6E~3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST)
CHRONIC [RfC] COMMENT: 6E-4 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY
TRICHLOROBENZENE, 1,2,4-
GENERAL COMMENT-
000120-82-1
INFORMATION REMOVED FROM THIS TABLE
SEE TABLE 1' SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN 1CITY).
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATICS: RISK INFORMATION HOTLINE. (513) 569-7254.
-------
HEAST TABLE 2:
DOSE SPECIES
ROUTE EXPERIMENT LENGTH TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXIC1TY
(OTHER THAN CARCINOGENICITY)
July 1997
CRITICAL EFFECT
Subchronic
[RfC] [RfO]
(rng/cum) (mq/ka/dav)
UF UF
Chronic
[RfC] [RfO]
(iro/cu m) dng/kg/dav)
UF UF
REFERENCE
TRICHLOROFLUOROMETHANE
LOAEL 1940 MG/KG/OAY
INHALATION-
CONTINUOUS
DOG
90 DAYS
000075-69-4
KIDNEY
LUNG
INCREASED BUN
INFLAMMATION
7E+0
1000
7E-1
10000
005501
SUBCHRONIC [RfC] COMMENT: 2E+0 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT. 2E-1 MG/KG/DAY (SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST}.
GENERAL COMMENT- THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP, ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE' (513) 569-7254.
2-9
-------
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
ACETONE CYANOHYDRIN 000075-86-5
010432 BLANK TL AND DC THAKE, 1984. THREE-MONTH INHALATION TOXICITY OF ACETONE CYANOHYORIN IN MALE AND FEMALE SPRAGUE-DAWLEY RATS. MONSANTO
REPORT NOP. MSL-4423. TSCA 8(0) SUBMISSION 878216397 (OTS 0510325).
US EPA. 1988, HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
ACETONITRILE 000075-05-8
005208 COATE WB. 1983 90-DAY SUBCHRONIC TOXICITY STUDY OF ACETONITRILE IN B6C3F1 MICE. FINAL REPORT (REVISED)
US EPA, 1987. HEALTH EFFECTS ASSESSMENT FOR ACETONITRILE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AW ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC.
BARIUH 007440-39-3
005249 TARASENKO M, 0 PROMIN AND A SILAYEV 1977. BARIUM COMPOUNDS AS INDUSTRIAL POISONS (AN EXPERIMENTAL STUDY). J HYG EPIDEM MICROBIOL
IMMUNOL. 21: 361.
US EPA 1984. HEALTH EFFECTS ASSESSMENT FOR BARIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
CHLORO-1,3-BUTADIENE / (CHLOROPRENE) 000126-99-8
005878 DU PONT DE NEMOURS AND COMPANY, INC. 1985. 2-YEAR INHALATION CARCINOGENICITY STUDY OF CHLOROPRENE IN RATS. El DU PONT DE NEMOURS AND CO.,
INC.. WILMINGTON. DE.
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS FOR 2-CHLORO-I.3-BUTADIENE. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
CHLOROBENZENE 000108-90-7
005353 DILLEY. JV 1977. TOXIC EVALUATION OF INHALED CHLOROBENZENE. NIOSH, DHEW, CINCINNATI. OH, CONTRACT 210-76-0126. CITED IN US EPA. 1985.
US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC.
CYCLOPENTADIENE 000542-92-7
005401 DOW. 1987 DATA. KM CHEMICAL. USA. MIDLAND, MI.
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC.
R2-1
-------
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
DICHLOROBENZENE, 1,2- 000095-50-1
005412 HQLLINGSWQRTH RL. VK ROME, F OYEN, TR TORKELSON AND EM ADAMS 1958. TOXICITY OF 0-DICHLOR06ENZ£NE AM MED ASSOC ARCH IND HEALTH. 17(1):
180-187.
US EPA, 1987 HEALTH EFFECTS ASSESSMENT FOR DICHLOROBENZENES, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSHENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC.
DICHLORODIFLUOROMETHANE 000075-71-8
005497 PRENOERGAST JA. RA JONES. LJ JENKINS AND J SIEGAL 1967 EFFECTS ON EXPERIMENTAL ANIMALS OF LONG-TERM INHALATION OF TRICHLOROETHYLENE.
TETRACHLORIOE. 1,1.1-TRICHLOROETHANE. DICHLORODIFLUQROMETHANE AND 1.1-DICHLOROETHYLENE. TOXICOL APPL PHARMACOL. 10 270-289
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
DICHLOROETHANE, 1,1- 000075-34-3
005789 HT. H BIRNSTIEL AND P JOBST, 1971 ON THE INHALATION TOXICITY OF 1.1- AND 1.2-DICHLOROETHANE. ARCH TOXIKQL 27. 248-265
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC.
OICYCLOPENTADIENE 000077-73-6
DODO OE. LC AND DL EISLER. 1982 DICYCLOPENTADIENE NINETY-DAY INHALATION STUDY ON RATS AND MICE RUN RESEARCH CENTER,
EXPORT. PA. TSCA 8E SUBMISSION BY EXXON CHEM AMER DOC ID 88-8300464, ODD DOC ID 8EHQ-0283-0364,MICROFICHE NO OTS 204864
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC
ETHOXYETHANOL ACETATE, 2- 000111-15-9
005952 UNION CARBIDE 1984 A TERATOGENIC EVALUATION OF CELLOSOLVE ACETATE IN FISHER 344 RATS AND NEW ZEALAND WHITE RABBITS FOLLOWING INHALATION
EXPOSURE. BUSHY RUN RESEARCH CENTER. EXPORT. PA, OCTOBER 1984 FYI-AX-1184-0360
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON. DC.
R2-2
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REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
FURFURAL 000098-01-1
005465 FERON VJ. A KRUYSSE AND HC DREEF VANDER MEULEN. 1979. REPEATED EXPOSURE TO FURFURAL VAPOR- 13 WEEK STUDY IN SYRIAN GOLDEN HAMSTERS.
ZENTRASE. BAKTEVIOL PAVASITEN KD INFECTION SKV HYG ABT 1 ORIG REIHE B. 168(5-6): 442-451.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR FURFURAL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON.DC
METHACRYLONITRILE 000126-98-7
005811 POZZAN1. UC. CR KINKEAD AND JM KING. 1968 THE MAMMALIAN TOXICITY OF METHACRYLONITRILE AM IND HYG ASSOC J. 29(3): 202-210.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
METHOXYETHANOL ACETATE, 2- 000110-49-6
010001 MILLER RR. LL CALHOUN AND BL YANO. 1982. ETHYLENE GLYCOL MONOMETHYL ETHER: 13-WEEK VAPOR INHALATION STUDY IN MALE RABBITS REPORT
PREPARED FOR THE CHEMICAL MANUFACTURERS ASSOCIATION. MARCH 25, 1982.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- METHOXYETHANOL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. OC
METHOXYETHANOL. 2- 000109-86-4
010910 MILLER RR. LL CALHOUN. BL YANO 1982. ETHYLENE GLYCOL MONOETHYL ETHER: 13 WEEK VAPOR INHALATION STUDY IN MALE RABBITS. REPORT PREPARED
FOR THE CMA MARCH 25. 1982.
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXYETHANOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
METHYL ACRYLATE 000096-33-3
010003 KLIMISCH HJ AND W REININGHAUS 1984 CARCINOGENICITY OF ACRYLATES LONG-TERM INHALATION STUDIES ON METHYL ACRYLATE (MA) AND N-BUTYL
ACRYLATE (BA) IN RATS. TOXICOLOGIST. 4(1) 53
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ACRYLATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
R2-3
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REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
METHYL ISOBUTYL KETONE 000108-10-1
005562 UNION CARBIDE CORP, 1983 NINETY-DAY INHALATION STUDY IN RATS AND MICE SPONSORED BY CMA US EPA/OTS PUBLIC FILES 0750507469.
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR METHYL ETHYL KETONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
METHYL STYRENE (MIXED ISOMERS) 025013-15-4
005567 MRI (MIDWEST RESEARCH INSTITUTE) 1984. STUDY OF THE INHALATION CARCINOGENICITY (BIOASSAY) OF VINYL TOLUENE IN B6C3F1 MICE
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYL STYRENES PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON, DC
005566 FINAL CHRONIC REPORT PERFORMED FOR THE NTP CONTRACT NO N01-ES-38042.
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYL STYRENES. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
METHYL STYRENE, ALPHA 000098-83-9
010016 WOLF MA. VK ROWE, DD MCCOLLISTER. ET AL 1956 TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENES AND BENZENE ARCH IND
HEALTH 14- 387-398.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALPHA- METHYL STYRENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
METHYLENE BROHIDE 000074-95-3
010011 KEYES DG. JW HENCK, GC JERSEY, RJ KOCIBA. DJ SCHWETZ AND TD LANDRY 1982 METHYLENE BROMIDE: A 90-DAY REPEATED INHALATION
TOXICITY STUDY IN RATS AND DOGS WITH A SUBSEQUENT TWO-YEAR HOLDING PERIOD FOR RATS. TOXICOLOGY RESEARCH LAB, HEALTH AND
ENVIRONMENTAL SCIENCES, DOW CHEMICAL CO , MIDLAND, ML
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYLENE BROMIDE. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON, DC.
R2-4
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REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1997
NITROBENZENE 000098-95-3
010518 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY) 1984. NINETY- DAY INHALATION STUDY OF NITROBENZENE IN F-344 RATS,CD RATS
AND B6C3F1 MICE WITH COVER LETTER DATED 6/24/84 AND EPA RESPONSE DATED 8/06/84. UNPUBLISHED STUDY, FYI-OTS-0784-0333 AND
COMPUTER PRINT-OUT OF PATHOLOGY FINDING.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR NITROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON.
DC.
TRICHLOROFLUOROMETHANE 000075-69-4
005501 JENKINS, LJ, RA JONES. RA COON AND J SIEGAL 1970. REPEATED AND CONTINUOUS EXPOSURES OF LABORATORY ANIMALS TO
TRICHLOROFLUORMETHANE. TOXICOL APPL PHARMACOL. 16: 133-142
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.
WASHINGTON. DC.
R2-5
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL
ACEPHATE
ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
030560-19-1
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayVHrng/kg/day)-1
IRIS IRIS
GENERAL COMMENT- ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)4 (ug/cu m)-l
IRIS
010086
ACROLEIN
000107-02-8
IRIS
GENERAL COMMENT ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ACRYLAMIDE
000079-06-1
ORAL: DRINKING
WATER
2 YEARS
RAT
IRIS
IRIS
4.5E+0
MAMMARY
THYROID
UTERUS
ORAL CAVITY
CENTRAL NERVOUS
SYSTEM
TUMORS
TUMORS
TUMORS
TUMORS
TUMORS
INHALATION [SLOPE] COMMENT. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
IRIS
005001
010087
ACRYLONITRILE
000107-13-1
IRIS
IRIS
IRIS
005004
INHALATION:
OCCUPATIONAL
IRIS
2 4E-1
HUMAN LUNG TUMORS
INHALATION [SLOPE] COMMENT SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
IRIS
005003
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-1
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEHICAL
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
(mg/kg/dayVHrng/kg/day)-1
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
ALACHLOR
ALDRIN
015972-60-8
ORAL: DIET MULTIPLE SITES TUHORS B2 8E-2
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINQGENICITY)
ORAL: DIET
MOUSE
000309-00-2
LIVER
IRIS
IRIS
1. 7E+1
CARCINOMA
INHALATION [SLOPE] COMMENT- SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
INHALATION [UNIT RISK] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ALLYL CHLORIDE
000107-05-1
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
2.3E-6
IRIS IRIS
010180
005006
010181
ANILINE 000062-53-3
IRIS IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1. AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010088
ARAHITE
ORAL- DIET
104 WKS
RAT
000140-57-8
LIVER
IRIS
IRIS
2.5E-2
TUMORS
IRIS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
010206
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-2
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
ARSENIC, INORGANIC
EXPERIMENT LENGTH
SPECIES
INHALATION:
OCCUPATIONAL HUMAN
TARGET CANCER
007440-38-2
RESPIRATORY TUMORS
SYSTEM
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayVKmg/kg/day)-1
IRIS
IRIS
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE I: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ASBESTOS 001332-21-4
IRIS
IRIS
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/LV1 (ug/cu m)-l
IRIS
IRIS
010925
005007
IRIS
005010
005919
ATRAZINE
ORAL: DIET
001912-24-9
2 YEARS
RAT
MAMMARY GLAND
MAMMARY GLAND
MAMMARY GLAND
MAMMARY GLAND
ADENOMA
FIBROADENOMA
ADENOCARCINOKA
CARCINOSARCOMA
2.22E-1
ORAL [SLOPE] COMMENT- UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
6.3E-6
010380
AZOBENZENE 000103-33-3
ORAL DIET 2 YEARS
RAT
IRIS
IRIS
1 1E-1
ABDOMINAL CAVITY SARCOMA
INHALATION [SLOPE] COMMENT. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
IRIS
IRIS
010089
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-3
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
BENZENE
EXPERIMENT LENGTH
SPECIES
TARGET
INHALATION:
OCCUPATIONAL
HUMAN
000071-43-2
BLOOD
CANCER
LEUKEMIA
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-1(mg/kg/day)4
IRIS
IRIS
2.9E-2
ORAL [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-!!. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/LV (ug/cu mM
IRIS
IRIS
005011
BENZIDINE 000092-87-5
IRIS IRIS IRIS
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
IRIS
005014
BENZOTRICHLORIDE
BENZO[A]ANTHRACENE
BENZO[A]PYRENE
BENZO[B]FLUORANTHENE
BENZO[K]FLUORANTHENE
BENZYL CHLORIDE
000098-07-7
000056-55-3
000050-32-8
000205-99-2
000207-08-9
IRIS IRIS
IRIS
IRIS IRIS
IRIS
IRIS
IRIS 010092
010182
IRIS 010508
010183
010090
000100-44-7
IRIS
IRIS
IRIS
010093
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MOHTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
3-4
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
BERYLLIUM
EXPERIMENT LENGTH
SPECIES
TARGET
007440-41-7
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP]
IRIS IRIS
GENERAL COMMENT ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
INHALATION:
OCCUPATIONAL HUMAN
IRIS
8.4E+0
LUNG TUMORS
INHALATION [SLOPE] COMMENT. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)"! (ug/cu m)-l
IRIS
IRIS
005018
005017
BIS(2-CHLOROETHYL) ETHER 000111-44-4
ORAL 560 DAYS
MOUSE LIVER
IRIS
IRIS
1.1E+Q
IRIS
IRIS
TUMORS
INHALATION [SLOPE] COMMENT: _BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST
BIS(2-CHLORO-1-METHYLETHYL) ETHER 000108-60-1
ORAL GAVAGE 2 YEARS
MOUSE LIVER
LUNG
7E-2
3.5E-2
2E-6
1E-5
TUMORS
TUMORS
005076
005079
INHALATION [SLOPE] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION (50% RESPIRATORY ABSORPTION) SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT. COMPOUND TESTED CONTAINED 701 BIS(2-CHLORO-1-METHYLETHYL)ETHER AND 30% BIS(2-CHLOROISOPROPYL)ETHER ALSO SEE HEAST TABLE 1:
SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
BIS(2-ETHYLHEXYL) PHTHALATE / (DEHP) 000117-81-7
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
005120
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
3-5
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HEAST TABLE 3; CARCINQGENICITY
July 1997
CHEMICAL
ROUTE
EXPERIMENTLENGTH
SPECIES
TARGET
BIS(CHLOROMETHYL) ETHER 000542-88-1
INHALATION; 10-100 DAYS
INTERMITTENT RAT RESPIRATORY
SYSTEM
CANCER
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-1(mg/kg/day)-1
IRIS
IRIS
2.2E+2
ORAL [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION
INHALATION [SLOPE] COMMENT; SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST,
BROHOOICHLOROHETHANE 000075-27-4
IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TGXICITY (OTHER THAN CARCINOGENICITY),
/ (VINYL BROMIDE) 000593-60-2
INHALATION: 2 YEARS
INTERMITTENT RAT LIVER
B2
1.1E-1
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
BROMOFORM 000075-25-2
ORAL- GAVAGE 2 YEARS IRIS
RAT INTESTINE. LARGE ADENOMATOUS POLYP
ADENOCARCINOMA
IRIS
3.9E-3
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/Lr1 (ug/cu m)-i
IRIS
IRIS
005077
IRIS
3 2E~5
005148
010094
IRIS
IRIS
005150
INHALATION [SLOPE] COMMENT. ON TO ROUTE EXTRAPOLATION SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
BUTADIENE. 1,3-
INHALATION:
INTERMITTENT
IRIS
000106-99-0
MOUSE MULTIPLE SITES TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
1.8E+0
IRIS
010477
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY- FURTHER INFORMATION: RISK INFORMATION HOTLINE- (513) 569-7254.
3-6
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HEAST TABLE 3: CARCINOGEN1CITY
July 1997
CHEMICAL ROUTE
BUTYL BENZYL PHTHALATE, N-
EXPERIMENT LENGTH
SPECIES
TARGET
000085-68-7
CANCER
CADMIUM
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-1(mg/kg/day)-1
IRIS
GENERAL COMMENT. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
007440-43-9
IRIS
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
005122
IRIS
ORAL [SLOPE] COMMENT THERE IS INADEQUATE EVIDENCE FOR THE CARCINOGENICITY OF THIS COMPOUND BY THE ORAL ROUTE.
GENERAL COMMENT. ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005019
CAPTAFOL
CAPTAN
002425-06-1
ORAL: DIET
8.6E-3
MOUSE
LYMPHATIC SYSTEM LYMPHOSARCOMA
ORAL [SLOPE] COMMENT- UNDER REVIEW. NUMBER SUBJECT TO CHANGE
GENERAL COMMENT ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
000133-06-2
B2
3.5E-3
ORAL [SLOPE] COMMENT. UNDER REVIEW. NUMBER SUBJECT TO CHANGE
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CARBAZOLE
ORAL: DIET
96 WEEKS
MOUSE
000086-74-8
LIVER
B2
2E-2
TUMORS
2.4E-7
l.OE-7
5.7E-7
010095
010184
010096
CARBON TETRACHLORIDE
ORAL: DIET
000056-23-5
LIVER
TUMORS
IRIS
IRIS
5 3E-2
IRIS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II DOSE CONVERSIONS ON HEAST
INHALATION [UNIT RISK] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION. INCORPORATES AN ABSORPTION FACTOR OF 0.4.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1' SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
005022
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-7
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
(mg/kg/dayrKmg/kg/day)-1
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/LV1 (ug/cu m)-l
CHLORANIL
ORAL. DIET
82 WEEKS
MOUSE
000118-75-2
LIVER
LUNG
TUMORS
TUMORS
4.03E-1
1.2E-5
010097
CHLORDANE
ORAL- DIET
MOUSE
000057-74-9
LIVER
IRIS
IRIS
1.3E+0
CARCINOMA
IRIS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II- DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT; ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY}.
CHLORO-2-METHYLANILINE HYDROCHLORIDE. 4-
ORAL: DIET 18 MONTHS
003165-93-3
B2
4.6E-1
1.3E-5
MOUSE
CHLORO-2-METHYLANILINE. 4-
ORAL- DIET 18 MONTHS
MOUSE
CARDIOVASCULAR HEMANGIQMA
SYSTEM
CARDIOVASCULAR HEMANGIOSARCOMA
SYSTEM
000095-69-2
B2
5.8E-1
1 6E-5
CARDIOVASCULAR HEMANGIOHA
SYSTEM
CARDIOVASCULAR HEMANGIOSARCOMA
SYSTEM
ORAL [SLOPE] COMMENT: BASED ON VASCULAR TUMORS IN MICE TREATED WITH 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE.
IRIS
005024
010419
010098
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY, FURTHER INFQffitATIQN: RISK INFORMATION HOTLINE: (513) 569-7254,
3-8
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HEAST TABLE 3: CARCINOGENICITY July 1997
[SLOPE FACTOR] [UNIT RISK]
EXPERIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/day)4(mg/kg/day)4 (ug/L)4 (ug/cu m)-l
CHLOROBENZILATE 000510-15-6
ORAL; SAVAGE. 82 WEEKS B2 2.11-1 2 7-E-l 7.8E-6 7.8E-5 010848
DIET MOUSE LIVER HEPATOMA
INHALATION [SLOPE] COMMENT. ABSORBANCE BY THE INHALATION ROUTE WAS ASSUMED TO EQUAL ORAL ABSORPTION SINCE THERE WERE NO
PHARMACOKINETIC DATA TO THE CONTRARY. SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST
INHALATION [UNIT RISK] COMMENT ABSORBANCE BY THE INHALATION ROUTE WAS ASSUHEO TO EQUAL ORAL ABSORPTION SINCE THERE WERE NO
PHARMACOKINETIC DATA TO THE CONTRARY.
GENERAL COMMENT ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLOROFORM 000067-66-3
IRIS IRIS IRIS 005036
ORAL. GAVAGE 78 WEEKS IRIS 8.1E-2 IRIS 005035
MOUSE LIVER CARCINOMA
INHALATION [SLOPE] COMMENT: ON ROUTE TO ROUTE EXTRAPOLATION, SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLOROMETHANE 000074-87-3
INHALATION- 24 MONTHS C 1.3E-2 6 3E-3 3 7E-7 1 8E-6 005038
INTERMITTENT KIDNEY TUMORS
ORAL [SLOPE] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENCIITY).
CHLOROMETHYL METHYL ETHER 000107-30-2
IRIS 005081
CHLORONITROBENZENE, 0- 000088-73-3
ORAL DIET 18 MONTHS B2 2.5E-2 7.1E-7 010099
MOUSE LIVER TUMORS
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 3-9
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
CHLORONITROBENZENE, P-
ORAL: DIET 18
MOUSE
TARGET
000100-00-5
CARDIOVASCULAR
SYSTEM
CANCER
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (fng/kg/dayr'dng/kg/day)-1
82 1.8E-2
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/cu m)-l
010100
5.1E-7
CHLOROTHALONIL
ORAL: DIET
001897-45-6
27-32 MONTHS
RAT KIDNEY
B2
1.1E-2
TUMOR
ORAL [SLOPE] COMMENT. UNDER REVIEW. NUMBER SUBJECT TO CHANGE,
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINQGENICITY).
CHROMIUM(VI)
INHALATION-
OCCUPATIONAL
HUMAN
018540-29-9
LUNG
IRIS
4 1E+1
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY).
CHRYSENE 000218-01-9
GENERAL COMMENT: SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINQGENICITY)
008007-45-2
HUMAN LUNG TUMORS
COKE OVEN EHISSIONS
INHALATION:
OCCUPATIONAL
IRIS
IRIS
2.2E+0
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT; FORMERLY LISTED UNDER COAL TARS,
3 1E-7
IRIS
IRIS
010384
005091
010185
005039
CREOSOTE, COAL TAR
008001-58-9
IRIS
005042
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-10
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayrHmg/kg/day)4
[UNIT RISK]
ORAL INHALATION
(ug/L)'1 (ug/cu m)-l
REFERENCE
CRESOL, M- / (3-METHYLPHENOU 000108-39-4
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CRESOL. 0- / (2-HETWLPHENOL) 000095-48-7
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CRESOL, P- / (4-METHYLPHENOL) 000106-44-5
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010187
010186
010188
IRIS 1.9E+0
CROTONALDEHYDE 000123-73-9
ORAL- DRINKING 113 MKS
WATER RAT LIVER TUMOR
ORAL [SLOPE] COMMENT: REVIEW. SUBJECT TO CHANGE,
CYANAZINE 021725-46-2
ORAL: DIET 2 YEARS C 8.4E-1
RAT MAMMARY GLAND ADENOMA/
CARCINOMA.
COMBINED
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRGNIC AND CHRONIC TOXICITY {OTHER THAN CARCINOGENICITY).
5.4E-5
2 4E-5
010190
010944
ODD
000072-54-8
IRIS IRIS
IRIS
010291
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254,
3-11
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
ODE
EXPERIMENT LENGTH
SPECIES TARGET
000072-55-9
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayrHmg/kg/day)4
IRIS
IRIS
[UNIT RISK]
ORAL INHALATION
(ug/cu m)-l
IRIS
REFERENCE
010292
DDT
ORAL- DIET
000050-29-3
MOUSE. RAT LIVER
IRIS
IRIS
3.4E-1
TUMORS
IRIS
INHALATION [SLOPE] COMMENT, BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SU8CHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
DECABROMODIPHENYL ETHER
001163-19-5
mis
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
005044
010102
DIALLATE
002303-16-4
ORAL
19 HQNTHS
MOUSE
LIVER
82
6.1E-2
1 7E~6
TUHORS
010103
DIBENZOEA,H]ANTHRACENE
000053-70-3
IRIS
010191
IRIS. EPA'S INTEGRATED RISK, INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-12
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HEAST TABLE 3: CARCINOGENICITY
July 1997
EXPERIHENT LENGTH
CHEMICAL ROUTE SPECIES
DIBROMO- 3 - CHLOROPROPANE .1,2
ORAL: DIET
TARGET
000096-12-8
STOMACH
KIDNEY
LIVER
CANCE!
TUMORS
TUMORS
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-1(mg/kg/day)-!
B2 1.4E+0
[EPA GROUP] COMMENT: UNDER REVIEW, CLASSIFICATION SUBJECT TO CHANGE
INHALATION [SLOPE] COMMENT. SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)"1 (ug/cu m)-l
4E-5
010484
INHALATION*
INTERHITTENT RAT.
NASAL CAVITY
TUMORS
2 4E-3
6 9E-7
01Q519
DIBROMOCHLORQMETHANE 000124-48-1
IRIS IRIS IRIS
GENERAL COMMENT FORMERLY LISTED AS CHLORODIBROMOMETHANE. ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY).
010891
DIBROMOETHANE, 1,2- 000106-93-4
GENERAL COMMENT FORMERLY LISTED UNDER ETHYLENE OIBROMIDE
IRIS
IRIS
IRIS
005818
INHALATION
INTERMITTENT
88-103 WEEKS
RAT
IRIS
7 6E-1
IRIS
008071
NASAL CAVITY
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT. ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
3-13
-------
HEAST TABLE 3: CARCINOGENIC1TY
July 1997
CHEMICAL ROUTE
DICHLORO-2-BUTENE, 1,4-
EXPERIMENT LENGTH
SPECIES
INHALATION 90 DAYS
INTERMITTENT RAT
TARGET CANCER
000764-41-0
NASAL PASSAGES TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayVHmg/kg/day)4
B2
9.3E-K)
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT, FORMERLY LISTED UNDER DICHLOROBUTENES
DICHLOROBENZENE, 1,4- 000106-46-7
ORAL: SAVAGE 103 WEEKS
MOUSE LIVER
2.4E-2
TUMORS
ORAL [SLOPE] COMMENT UNDER REVIEW, NUMBER SUBJECT TO CHANGE
GENERAL COMMENT: ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TQXICITY (OTHER THAN CARCINOGENICITY).
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
2 6E-3
005053
6 8E-7
005050
DICHLOROBENZIDINE. 3,3'-
000091-94-1
IRIS IRIS
IRIS
005815
DICHLOROETHANE, 1,1-
000075-34-3
IRIS
GENERAL COMMENT. ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY}
005055
OICHLOROETHANE, 1,2- 000107-06-2
ORAL. GAVAGE 78 WEEKS
RAT CIRCULATORY
SYSTEM
IRIS
IRIS
SARCOMA
GENERAL COMMENT. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY}
IRIS
IRIS
005058
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE (513) 569-7254.
3-14
-------
HEAST TABLE 3: CARCINOGENICITY July 1997
[SLOPE FACTOR] [UNIT RISK]
EXPERIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/dayrHmg/kg/day)4 (ug/L)4 Cug/cu m)-l
DICHLOROETHYLENE, 1,1- 000075-35-4
IRIS IRIS IRIS 005060
INHALATION 12 MONTHS IRIS 1.2E+0 IRIS 005059
MOUSE KIDNEY ADENOCARCINOMA
INHALATION [SLOPE] COMMENT, SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COHHENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY),
DICHLOROPROPANE, 1,2- 000078-87-5
ORAL: GAVAGE B2 6.8E-2 1.9E-6 005062
MOUSE LIVER TUMORS
ORAL [SLOPE] COMMENT. UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT; ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 3-15
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL
ROUTE
DICHLOROPROPENE. 1,3-
ORAL. SAVAGE
DIELDRIN
EXPERIMENT LENGTH
SPECIES
/ (TELONE II)
104 WEEKS
MOUSE
ORAL: GAVAGE 104 WEEKS
RAT
TARGET
000542-75-6
BLADDER
RESPIRATORY
SYSTEM
FQRESTOMACB
LIVER
FORESTOMACH
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'Cmg/kg/day)-1
IRIS
CARCINOMA
ALVEOLAR/
8RONCHIOLAR
ADENOMA
PAPILLQMA/
CARCINOMA
NEOPLASTIC
NODULE/CARCINOHA
PAPILLOMA/
CARCINOMA
1 8E-1
ORAL [SLOPE] COMMENT- THE [SLOPE] IS THE GEOMETRIC MEAN OF SLOPE FACTORS OF COMBINED TUMORS LISTED
GENERAL COMMENT ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
INHALATION:
INTERMITTENT
2 YEARS
MOUSE
IRIS
1 3E-1
LUNG
ADENOMA
INHALATION [SLOPE] COMMENT- SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ORAL. DIET
MOUSE
000060-57-1
LIVER
IRIS
IRIS
1.6E+1
CARCINOMA
INHALATION [SLOPE] COMMENT, SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
INHALATION [UNIT RISK] COMMENT BASED ON ROUTE-TO-ROUTE EXTRAPOLATION
GENERAL COMMENT- ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 Cug/cu m)-l
5E-6
010946
3.7E-5
010104
IRIS
IRIS
005816
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE- (513) 569-7254.
3-16
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
OIETHYLSTILBESTROL
ORAL DIET
EXPER1HEMT LENGTH
SPECIES TARGET CANCER
000056-53-1
MOUSE MAMMARY GLAND CARCINOMA
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-1(mg/kg/day)-1
4.7E+3
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/LT1 (ug/cu m)-l
1 3E-1
010485
DIHETHOXYBENZIDINE, 3,3'- 000119-90-4
ORAL: DIET LIFETIME B2
HAMSTER FORESTOMACH PAPILLOMA
1 4E-2
4E-7
010106
DIMETHYLANILINE HYDROCHLORIDE, 2,4- 021436-96-4
ORAL: DIET 18 MONTHS
MOUSE LUNG
TUMORS
5 8E-1
1.7E-5
010108
DIMETHYLANILINE, 2,4- 000095-68-1
ORAL: DIET 18 MONTHS
MOUSE LUNG
TUMORS
7.5E-1
2.1E-5
010107
DIHETHYLBENZIDINE, 3,3'- 000119-93-7
ORAL: GAVAGE 30 DAYS
RAT MAMMARY
TUMORS
B2
9 2E+0
2 6E-4
010109
DIMETHYLHYDRAZINE, 1,1- 000057-14-7
GENERAL COMMENT: NO EPA GROUP CLASSIFICATION WAS PROVIDED IN THE REFERENCE DOCUMENT, THEREFORE THIS COMPOUND WAS
REMOVED FROM TABLE 3
DIMETHYLHYDRAZINE, 1,2-
DIMETHYLSULFATE
000540-73-8
000077-78-1
B2
IRIS
010962
010112
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
3-17
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-1(mg/kg/day)-1
[UNIT RISK]
ORAL INHALATION
(ug/L)-1 (ug/cu m)-l
REFERENCE
DINITROTOLUENE. 2.4- 000121-14-2
IRIS IRIS IRIS
GENERAL COMMENT: LISTED AS "DINITROTOLUENE MIXTURE. 2.4-/2.6-'1 ON IRIS. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY).
005066
DINITROTOLUENE. 2,6- 000606-20-2
IRIS IRIS IRIS
GENERAL COMMENT: LISTED AS "DINITROTOLUENE MIXTURE. 2.4-/2.6-'1 ON IRIS. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY).
005068
DIOXANE, 1,4-
000123-91-1
IRIS
IRIS
IRIS
010298
DIPHENYLHYDRAZINE, 1.2- 000122-66-7
ORAL: DIET 2 YEARS
RAT LIVER
IRIS IRIS
8.0E-1
IRIS
IRIS
TUMORS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
005070
DIRECT BLACK 38
ORAL- DIET
DIRECT BLUE 6
ORAL: DIET
001937-37-7
LIVER TUMORS
ORAL [SLOPE] COMMENT: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
002602-46-2
LIVER TUMORS
ORAL [SLOPE] COMMENT- UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
93 DAYS
RAT
91 DAYS
RAT
8.6E-K)
2.4E-4
8.1E-K)
2.3E-4
010113
010114
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-18
-------
HEAST TABLE 3: CARCINOGEN1CITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
DIRECT BROWN 95
ORAL: DIET
TARGET CANCER
016071-86-6
LIVER TUMORS
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
91 DAYS
RAT
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayrHmg/kg/day)'1
9.3E-K)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
2 6E-4
010115
DIRECT SKY BLUE 6B
002610-05-1
B2
[EPA GROUP] COMMENT: BASED ON THE FACT THAT 3.3-DIMETHOXYBENZIDINE. A KNOWN EPA GROUP B2 CARCINOGEN. IS A METABOLITE
OF DIRECT SKY BLUE 6B.
EPICHLOROHYDRIN
INHALATION:
INTERMITTENT
000106-89-8
30 DAYS.
OBSERVED LIFETIME
RAT NASAL CAVITY
IRIS
IRIS
IRIS
IRIS
4.2E-3
IRIS
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010116
010198
010117
ETHYL ACRYLATE
ORAL. GAVAGE
000140-88-5
104 WEEKS
RAT
B2
4 8E-2
1 4E-6
FORESTOMACH
TUMORS
010118
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-19
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
ETHYLENE OXIDE
ORAL- GAVAGE
EXPERIMENT LENGTH
SPECIES
TARGET
[SLOPE FACTOR]
[EPA ORAL INHALATION
CANCER GROUP] (mg/kg/dayJ'Hmg/kg/day)0
000075-21-8
LIFETIME, TWICE WEEKLY
RAT STOMACH
TUMORS
ORAL [SLOPE] COMMENT- UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
INHALATION.
INTERMITTENT
2 YEARS
RAT
BLOOD
BRAIN
LEUKEMIA
GLIOMA
61 1.02E+0
Bl 3.5E-1
ETHYLENE THIOUREA
ORAL. GAVAGE
INHALATION [UNIT RISK] COMMENT- UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
000096-45-7
2 YEARS
MOUSE
LIVER
82
ADENOMA/
CARCINOMA, COMBINED
1.1E-1
GENERAL COMMENT: ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)4 (ug/cu m)-l
2.9E-5
1E-4
3.4E-6
010421
010422
010947
FOLPET 000133-07-3
IRIS IRIS
GENERAL COMMENT ALSO SEE HEAST TABLE 1- SU6CHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
010120
FORMALDEHYDE
INHALATION
000050-00-0
24 MONTHS
RAT
IRIS
4 5E-2
NASAL CAVITY
TUMORS
INHALATION [SLOPE] COMMENT- SEE APPENDIX A-1I: DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
010121
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION- RISK INFORMATION HOTLINE- (513) 569-7254.
3-20
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
FURAZOLIDONE
ORAL- DIET
TARGET CANCER
000067-45-8
MAMMARY TUMORS
GENERAL COMMENT. FORMERLY LISTED UNDER NITROFURANS
45 WEEKS
RAT
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayJ-'Cmg/kg/day)-1
B2 3 8E+0
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)"1 (ug/cu m)-l
1E-4
005106
FURIUM
000531-82-8
ORAL: DIET
28 WEEKS
MOUSE
BLOOD
GENERAL COMMENT. FORMERLY LISTED UNDER NITROFURANS
LEUKEMIA
B2
5 OE+1
1 4E-3
005108
GLYCIDALDEHYDE
000765-34-4
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
HEPTACHLOR
ORAL: DIET
MOUSE
000076-44-8
LIVER
IRIS
IRIS
4.5E+0
CARCINOMA
IRIS
INHALATION [SLOPE] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
HEPTACHLOR EPOXIDE
ORAL: DIET
001024-57-3
18-24 MONTHS
MOUSE LIVER
IRIS
IRIS
9.1E+0
IRIS
CARCINOMA
INHALATION [SLOPE] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
IRIS
010122
005820
010424
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-21
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
HEXACHLOROBENZENE
ORAL: DIET
EXPERIMENT LENGTH
SPECIES
[SLOPE FACTOR] [UNIT RISK]
[EPA ORAL INHALATION ORAL INHALATION REFERENCE
RAT
TARGET
000118-74-1
LIVER
CANCER
TUMORS
GROUP] (mg/kg/day)4(mg/kg/day)~
(ug/L)-1 (ug/cu m)-l
IRIS
IRIS
1.6E+0
IRIS
INHALATION [SLOPE] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRQNIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN 1CITY).
IRIS
010365
HEXACHLOROBUTADIENE
ORAL: DIET
000087-68-3
22-24 MONTHS
RAT KIDNEY
IRIS
IRIS
7.8E-2
IRIS
TUMORS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
HEXACHLOROCYCLOHEXANE. ALPHA- 000319-84-6
ORAL: DIET 24 WEEKS
MOUSE LIVER
IRIS
IRIS
6.3E+0
IRIS
TUMORS
INHALATION [SLOPE] COMMENT- ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
HEXACHLOROCYCLOHEXANE, BETA- 000319-85-7
ORAL: DIET 110 WEEKS
MOUSE LIVER
IRIS
IRIS
1.8E+0
IRIS
TUMORS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
IRIS
IRIS
IRIS
005088
010123
010124
HEXACHLOROCYCLOHEXANE, DELTA- 000319-86-8
IRIS
GENERAL COMMENT- ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010125
IRIS
HEXACHLOROCYCLOHEXANE. EPSILON- 006108-10-7
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
MS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY, FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
010126
3-22
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayrKmg/kg/dayr1
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
HEXACHLOROCYCLOHEXANE. GAHMA- 000058-89-9
ORAL: DIET 110 WEEKS
MOUSE LIVER
B2-C
1.3E+0
TUMORS
ORAL [SLOPE] COMMENT UNDER REVIEW, SUBJECT TO CHANGE.
GENERAL COMMENT- ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY}.
3.7E-5
005098
HEXACHLOROCYCLOHEXANE-TECHNICAL 000608-73-1
ORAL: DIET 6-20 MONTHS
LIVER
IRIS IRIS
1.8E+0
IRIS IRIS
TUMORS
INHALATION [SLOPE] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-I1. DOSE CONVERSIONS ON HEAST.
010127
HEXACHLOROETHANE 000067-72-1
ORAL. GAVAGE 78 WEEKS
MOUSE LIVER
IRIS
IRIS
1 4E-2
IRIS
CARCINOMA
INHALATION [SLOPE] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY}.
HYDRAZINE
000302-01-2
INHALATION: 1 YEAR
INTERMITTENT RAT
IRIS
IRIS
IRIS
IRIS
1 7E+1
NASAL CAVITY TUMORS
INHALATION [SLOPE] COMMENT SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST
IRIS
IRIS
005090
010129
010128
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE; (513) 569-7254.
3-23
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
HYDRAZINE SULFATE
EXPERIMENT LENGTH
SPECIES
TARGET
010034-93-2
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-1
INHALATION: 1 YEAR
INTERMITTENT RAT
IRIS IRIS
IRIS
1 7E+1
NASAL CAVITY TUMORS
INHALATION [SLOPE] COMMENT- SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT LISTED UNDER "HYDRAZINE" ON IRIS.
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)u (ug/cu m)-l
IRIS
IRIS
010131
010130
INDENO[1.2.3-CD]PYRENE
000193-39-5
IRIS
010192
ISOPHORONE 000078-59-1
IRIS IRIS IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005094
LEAD
LINURON
007439-92-1
IRIS
GENERAL COMMENT ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000330-55-2
IRIS
GENERAL COMMENT. ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
MERCURIC CHLORIDE
007487-94-7
IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005096
010383
010971
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254
3-24
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
MERCURY, ELEMENTAL
EXPERIMENT LENGTH
SPECIES TARGET
007439-97-6
[SLOPE FACTOR]
[EPA ORAL INHALATION
CANCER GROUP] (mg/kg/dayrHmgAg/day)-1
IRIS
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)"1 (ug/cu mM
010973
GENERAL COMMENT ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHOXY-5-NITROANILINE, 2- 000099-59-2
ORAL. DIET 104 WEEKS
RAT SKIN
B2
4.6E-2
1 3E-6
010132
CARCINOMA
METHYLHYDRAZINE 000060-34-4
GENERAL COMMENT- NO EPA GROUP CLASSIFICATION WAS PROVIDED IN THE REFERENCE DOCUMENT, THEREFORE THIS COMPOUND WAS REMOVED FROM TABLE 3
METHYL-5-NITROANILINE, 2- 000099-55-8
ORAL- DIET 98 WEEKS
MOUSE LIVER
CARCINOMA
3 3E-2
9.4E-7
010140
METHYLANILINE HYDROCHLORIDE. 2- 000636-21-5
ORAL- DIET 93 WEEKS
RAT SKIN
B2
FIBROMA
1 8E-1
5.1E-6
010134
METHYLANILINE. 2-
ORAL- DIET
000095-53-4
93 WEEKS
RAT
B2
2.4E-1
6 9E-6
SKIN FIBROMA
GENERAL COMMENT THE 1984 HEEP CALLED THIS COMPOUND 0-TOLUIDINE. THE 1987 HEEP CALLED IT 2-METHYLANILINE
010133
METHYLENE CHLORIDE / (DICHLOROMETHANE) 000075-09-2
IRIS IRIS
IRIS
IRIS
GENERAL COMMENT. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
005100
005904
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE; (513) 569-7254.
3-25
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENTLENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayrHmg/kg/day)'
[UNIT RISK]
ORAL INHALATION
(ug/L)4 (ug/cu m)-l
REFERENCE
METHYLENE-BIS(BENZENEAMINE), 4,4- / (4,4'-HETHYLENEDIANILINE) 000101-77-9
GENERAL COMMENT. NO EPA GROUP CLASSIFICATION WAS PROVIDED IN THE REFERENCE DOCUMENT, THEREFORE THIS COMPOUND WAS REMOVED FROM TABLE 3
METHYLENE-BIS(2-CHLOROANILINE), 4,4'- 000101-14-4
ORAL: DIET 2 YEARS
RAT LUNG
B2
1.3E-1
1 3E-1
3.7E-6 3.7E-5
010425
TUMORS
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II: DOSE CONVERSIONS ON HEAST. BASED ON ROUTE TO ROUTE EXTRAPOLATION
METHYLENE-BIS(N,N'-DIHETHYL)ANILINE, 4,4'- 000101-61-1
IRIS IRIS
GENERAL COMMENT; ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS
IRIS
METHYLMERCURY 0022967-92-6
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
METOLACHLOR 051218-45-2
MIREX
ORAL: DIET
2 YEARS
RAT
002385-85-5
LIVER
LIVER
IRIS
B2
ADENOMA
CARCINOMA
[EPA GROUP] COMMENT: UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
NIAGARA BLUE 4B
002429-74-5
B2
[EPA GROUP] COMMENT: BASED ON THE FACT THAT 3,3-QIMETHOXYBENZIDINE, A KNOWN EPA GROUP B2 CARCINOGEN. IS A
METABOLITE OF NIAGARA BLUE 4B.
010137
010972
010951
010952
010141
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-26
-------
HEAST TABLE 3: CARC1NOGENICITY July 1997
[SLOPE FACTOR] [UNIT RISK]
LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/dayr'dng/kg/dayr1 (ug/L)4 (ug/cu m)-l
NICKEL REFINERY DUST
INHALATION: IRIS 8.4E-1 IRIS 005103
OCCUPATIONAL HUMAN RESPIRATORY TUMORS
SYSTEM
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT: FORMERLY LISTED AS NICKEL, ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (UNDER NICKEL, SOLUBLE SALTS).
NICKEL SUBSULFIDE 012035-72-2
INHALATION: IRIS 1.7E+0 IRIS 005768
OCCUPATIONAL HUMAN RESPIRATORY TUMORS
SYSTEM
INHALATION [SLOPE] COMMENT: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT' FORMERLY LISTED AS NICKEL. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (UNDER NICKEL).
NITROBENZENE 000098-95-3
INHALATION 2 YEAR B2 010969
INHALATION
2 YEAR
MICE
2 YEAR
RAT
LUNG
LUNG
THYROID
MAMMARY
LIVER
LIVER
KIDNEY
KIDNEY
UTERUS
B2
ADENOMA
CARCINOMA
ADENOMA
ADENOCARCINOMA
ADENOMA
CARCINOMA
ADENOMA
ADENOCARCINOMA
ENDIOHETRIAL POLYPS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 3-27
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayrHmg/kg/day)'1
[UNIT RISK]
ORAL INHALATION
(ug/L)4 (ug/cu m)-l
REFERENCE
NITROFURAZONE
ORAL DIET
46 WEEKS
RAT
000059-87-0
MAMMARY
B2
1.5E+0
TUMORS
4.3E-5
005110
NITROPROPANE, 2- 000079-46-9
INHALATION 22 MONTHS
INTERMITTENT RAT
B2
9 4E+0
LIVER TUMORS
INHALATION [SLOPE] COMMENT SEE APPENDIX A-II- DOSE CONVERSIONS ON HEAST,
NITROSO-DI-N-BUTYLAMINE, N- 000924-16-3
ORAL- DRINKING LIFETIME
WATER MOUSE BLADDER
ESOPHAGUS
IRIS
IRIS
5 4E+0
TUMORS
TUMORS
2 7E-3
IRIS
IRIS
INHALATION [SLOPE] COMMENT. BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST
010142
010143
NITRQSQ-DI-N-PROPYLAMINE, N- 000621-64-7
IRIS
IRIS
IRIS
010147
NITRQSO-N-ETHYLUREA, N- 000759-73-9
ORAL: DRINKING 203 DAYS
WATER RAT INTESTINE
82
GASTROINTESTINAL
TUMORS
1.4E+2
[EPA GROUP] COMMENT. UNDER REVIEW, CLASSIFICATION SUBJECT TO CHANGE.
010426
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254
3-28
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
NITROSO-N-METHYLUREA. N-
ORAL- GAVAGE 308 DAYS
GUINEA PIG
TARGET
000684-93-5
PANCREAS
CANCER
[SLOPE FACTOR] [UNIT RISK]
[EPA ORAL INHALATION ORAL INHALATION REFERENCE
GROUP] (mg/kg/dayr'Ong/kg/dayr1 (ug/l)-1 (ug/cu m)-l
B2
ADENOCARCINOMA
[EPA GROUP] COMMENT- UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE
GENERAL COMMENT- THE CRAVE WORK GROUP (04/01/92) STATES THERE IS NO ACCEPTABLE QUANTITATION FOR NITROSO-N-METHYLUREA. N-.
010427
NITROSODIETHANOLAMINE, N-
001116-54-7
NITROSODIETHYLAMINE, N- 000055-18-5
ORAL- DRINKING 6 OR 12 MONTHS
WATER RAT LIVER
IRIS IRIS
IRIS IRIS
1.5E+2
IRIS
IRIS IRIS
TUMORS
INHALATION [SLOPE] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
000062-75-9
IRIS IRIS 5 1E+1
LIVER TUMORS
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
NITROSODIMETHYLAMINE, N-
ORAL: DRINKING
WATER RAT
IRIS IRIS
010144
010145
010146
NITROSODIPHENYLAMINE. N-
000086-30-6
IRIS IRIS
IRIS
005112
NITROSOMETHYLETHYLAMINE, N- 010595-95-6
IRIS IRIS
IRIS
010148
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
3-29
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL
EXPERIMENT LENGTH
SPECIES
NITROSOMETHYLVINYLAHINE, N
INHALATION
RAT
ORAL: DRINKING
WATER
TARGET
004549-40-0
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayVHmg/kg/day)'
B2
UPPER RESPIRATORY CARCINOMAS
TRACT
UPPER DIGESTIVE CARCINOMAS
TRACT
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/LV1 (ug/cu m)-l
010149
NITROSOPYRROLIDINE. N- 000930-55-2
ORAL: DIET LIFETIME
RAT LIVER
IRIS IRIS
2.1E+0
IRIS IRIS
TUMORS
INHALATION [SLOPE] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION, SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
010300
PARATHION
000056-38-2
IRIS
GENERAL COMMENT- ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINQGENICITY)
005116
PENTABRQNO-6-CHLOROCYGLOHEXANE, 1,2,3,4,5- 000087-84-3
ORAL DIET 2 YEARS
RAT INTESTINE, LARGE TUMORS
ORAL [SLOPE] COMMENT: BASED ON RESULTS WITH THE ALPHA ISOMER.
2 3E-2
6.6E-7
01Q15Q
PENTACHLORONITROBENZENE 000082-68-8
ORAL 72 WEEKS
MOUSE LIVER
TUMORS
2.6E-1
7.4E-6
ORAL [SLOPE] COMMENT: REVIEW, SUBJECT TO
GENERAL COMMENT; ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
010151
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
3-30
-------
HEAST TABLE 3: CARCINOGENIGITY
July 1997
CHEMICAL ROUTE
PENTACHLOROPHENOL
EXPERIHENT LENGTH
SPECIES
TARGET
000087-86-5
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-1(mg/kg/day)'1
IRIS IRIS
GENERAL COMMENT ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICJTY)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)~1 (ug/cu m)-l
IRIS
010381
PHENYLENEDIAMINE. 0-
QRAL- DIET
548 DAYS
RAT
000095-54-5
LIVER
B2
4.7E-2
TUMORS
ORAL [SLOPE] COMMENT. BASED ON LIVER TUMORS IN RATS TREATED WITH Q-PHENYLENEDIAMINE DIHYDROCHLORIDE.
GENERAL COMMENT- ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY.
1 3E-6
010152
PHENYLPHENOL. 2-
ORAL. DIET
000090-43-7
637 DAYS
RAT
URINARY BLADDER TUMORS
1.94E-3
5 5E-J
010153
POLYBROMINATED BIPHENYLS
ORAL GAVAGE 25 WEEKS
RAT
LIVER
LIVER
82
CARCINOMA
NEOPLASTIC NODULE
8.9E-K)
GENERAL COMMENT: ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
POLYCHLORINATED BIPHENYLS
001336-36-3
IRIS
IRIS
GENERAL COMMENT. CARCINOGENICITY INFORMATION WAS CHANGED ON IRIS
2 5E-4
IRIS
010154
005118
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION, RISK INFORMATION HOTLINE: (513) 569-7254
3-31
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
PROPYLENE OXIDE
EXPERIMENT LENGTH
SPECIES
TARGET
000075-56-9
[SLOPE FACTOR]
[EPA ORAL INHALATION
CANCER GROUP] (mg/kg/dayVHrng/kg/day)4
INHALATION, 2 YEARS
INTERMITTENT MOUSE
IRIS
IRIS
IRIS
1 3E~2
NASAL CAVITY
TUMORS
INHALATION [SLOPE] COMMENT SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT; ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINQGENICITY).
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
IRIS 010156
IRIS 010155
QUINOLINE 000091-22-5
ORAL- DIET 20-40 WEEKS
RAT LIVER
1.2E+1
TUMORS
3 5E~4
010158
RDX / (CYCLONITE) 000121-82-4
IRIS IRIS IRIS
GENERAL COMMENT; ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010157
SELENIUM SULFIDE
007446-34-6
IRIS
ORAL [SLOPE] COMMENT STUDY RESULTS WERE CONSIDERED INCONCLUSIVE FOR QUANTITATIVE RISK ASSESSMENT
SIMAZINE
ORAL. DIET
2 YEARS
RAT
000122-34-9
MAMMARY
1 2E-1
CARCINOMA
ORAL [SLOPE] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE
GENERAL COMMENT: ALSO SEE HEAST TABLE 1, SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
3 4E-6
010194
010195
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY, FURTHER INFORMATION. RISK INFORMATION HOTLINE. (513)569-7254
3-32
-------
HEAST TABLE 3: CARCINOGEN1CITY
July 1997
CHEMICAL
ROUTE
EXPERIMENT LENGTH
SPECIES
SODIUM DIETHYLDITHIOCARBAMATE
ORAL: DIET 77 WEEKS
MOUSE
TARGET
000148-18-5
LIVER
CANCER
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-1(mg/kg/day) l
2.7E-1
GENERAL COMMENT ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
STYRENE 000100-42-5
GENERAL COMMENT- CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
TCDD. 2,3.7,8-
ORAL: DIET
001746-01-6
720 DAYS
RAT
B2
1 5E+5
1 5E+5
RESPIRATORY
SYSTEM
LIVER
TUMORS
TUMORS
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)"1 (ug/cu m)-l
7.7E-6
005126
4.5E+0
3.3E-5
(PG/CU MM
010480
005128
ORAL [SLOPE] COMMENT UNDER REVIEW. NUMBER SUBJECT TO CHANGE.
INHALATION [SLOPE] COMMENT- SEE APPENDIX A-II- DOSE CONVERSIONS ON HEAST
INHALATION [UNIT RISK] COMMENT: UNDER REVIEW. NUMBER SUBJECT TO CHANGE BASED ON ROUTE TO ROUTE EXTRAPOLATION
AN ABSORPTION FACTOR OF 75% IS USED TO CALCULATE THE UNIT RISK FROM THE SLOPE FACTOR
TETRACHLOROETHANE, 1.1.1.2- 000630-20-6
ORAL GAVAGE 103 WEEKS
LIVER
IRIS IRIS
2.6E-2
IRIS IRIS
010302
TUMOR
INHALATION [SLOPE] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION. RISK INFORMATION HOTLINE: (513) 569-7254.
3-33
-------
HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (ing/kg/day)-1(mg/kg/day)-!
TARGET CANCER
000079-34-5
LIVER CARCINOMA
INHALATION [SLOPE] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)-l
TETRACHLOROETHANE, 1,1,2,2-
ORAL. GAVAGE 75 WEEKS
MOUSE
IRIS
IRIS
2 OE-1
IRIS
IRIS
005130
TETRACHLOROETHYLENE
000127-18-4
GENERAL COMMENT: CONTACT THE HEALTH RISK TECHNICAL SUPPORT CENTER- (513) 569-7300
ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY}
010482
TETRACHLOROTOLUENE, PARA, ALPHA, ALPHA, ALPHA-
ORAL- GAVAGE 17 5 WEEKS
MOUSE LUNG
005216-25-1
B2 2.0E+1
ADENOCARCINOMA
5 7E-4
005028
TETRACHLOROVINPHOS / (STIROFOS) 000961-11-5
ORAL: DIET 560 DAYS
MOUSE LIVER
TUMORS
2.4E-2
[EPA GROUP] COMMENT REVIEW, CLASSIFICATION SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TOLUENE-2.4-DIAMINE
ORAL. DIET
000095-80-7
84-103 WEEKS
RAT MAMMARY
82
3.2E-M3
TUMORS
6.9E-7
9.1E-5
010159
010160
TOLUIDINE, P-
ORAL. DIET
000106-49-0
18 MONTHS
MOUSE
LIVER
1 9E-1
TUMORS
5 4E-6
010162
MS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-34
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HEAST TABLE 3: CARCINOGEN1CITY
July 1997
CHEMICAL ROUTE
TOXAPHENE
EXPERIMENT LENGTH
SPECIES
ORAL DIET
18 MONTHS
MOUSE
TARGET
008001-35-2
LIVER
CANCER
TUMORS
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)'1
IRIS
INHALATION [SLOPE] COMMENT SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST
INHALATION [UNIT RISK] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
IRIS
1 1E+0
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)-l
IRIS
IRIS
005134
TRICHLOROANILINE HYDROCHLORIDE. 2,4,6-
ORAL. DIET 18 MONTHS
MOUSE
033663-50-2
c
VASCULAR SYSTEM TUMORS
2 9E-2
3.2E-7
005142
TRICHLOROANILINE. 2,4,6- 000634-93-5
ORAL. DIET 18 MONTHS
MOUSE VASCULAR SYSTEM
TUMORS
3 4E-2
1E-6
010487
TRICHLOROETHANE, 1,1,2- 000079-00-5
ORAL GAVAGE 78 WEEKS
MOUSE LIVER
IRIS
CARCINOMA
IRIS
5.7E-2
IRIS
IRIS
INHALATION [SLOPE] COMMENT BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST
GENERAL COMMENT. ALSO SEE HEAST TABLE 1- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
005144
TRICHLOROETHYLENE 000079-01-6
GENERAL COMMENT CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300
010483
IRIS. ERA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254.
3-35
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HEAST TABLE 3: CARCINOGENICITY
July 1997
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TRICHLOROPHENOL, 2,4.6-
ORAL: DIET 107 WEEKS
RAT
TARGET
000088-06-2
BLOOD
CANCER
LEUKEMIA
[SLOPE FACTOR] [UNIT RISK]
[EPA ORAL INHALATION ORAL INHALATION REFERENCE
GROUP] (mg/kg/day) '(mg/kg/day)'1 (ug/Lr1 (ug/cu m)-l
IRIS
IRIS
11-2
IRIS
IRIS
INHALATION [SLOPE] COMMENT- BASED ON ROUTE TO ROUTE EXTRAPOLATION SEE APPENDIX A-II. DOSE CONVERSIONS ON HEAST.
GENERAL COMMENT. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TRICHLOROPROPANE. 1.2.3-
ORAL- GAVAGE
RAT
000096-18-4
MULTIPLE SITES
62
TUMORS.
BENIGN/MALIGNANT.
COMBINED
7E+0
[EPA GROUP] COMMENT: UNDER REVIEW. CLASSIFICATION SUBJECT TO CHANGE
GENERAL COMMENT: ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
2E-4
010428
010849
TRIFLURALIN 001582-09-8
IRIS IRIS
GENERAL COMMENT. ALSO SEE HEAST TABLE 1 SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
010163
TRIMETHYL PHOSPHATE
ORAL. GAVAGE
000512-56-1
103 WEEKS
MOUSE
B2
3.7E-2
UTERUS
TUMORS
1 1E-6
010164
TRINITROTOLUENE, 2,4,6- 000118-96-7
IRIS IRIS
GENERAL COMMENT. ALSO SEE HEAST TABLE 1. SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS
010476
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY. FURTHER INFORMATION: RISK INFORMATION HOTLINE. (513) 569-7254.
3-36
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HEAST TABLE 3: CARCINOGENICITY July 1997
[SLOPE FACTOR] [UNIT RISK]
EXPERIMENT LENGTH [EPA ORAL INHALATION ORAL INHALATION REFERENCE
CHEMICAL ROUTE SPECIES TARGET CANCER GROUP] (mg/kg/dayJ'Hmg/kg/day)4 (ug/L)'1 (ug/cu m)-l
VINYL CHLORIDE 000075-01-4
ORAL: DIET 1001 DAYS A 1.9E+Q 5.4E-5 010368
RAT LUNG TUMORS
LIVER TUMORS
ORAL [SLOPE] COMMENT- UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
INHALATION- 1 YEAR A 3 OE-1 8 4E-5 010367
INTERMITTENT RAT LIVER TUMORS
INHALATION [SLOPE] COMMENT SEE APPENDIX A-II- DOSE CONVERSIONS ON HEAST.
INHALATION [UNIT RISK] COMMENT- REVIEW, SUBJECT TO CHANGE.
GENERAL COMMENT- THE MOST RECENTLY REVIEWED QUANTITATIVE TOXICITY VALUES LISTED HERE APPEAR IN EPA DOCUMENTS PUBLISHED IN 1984 AND 1985. USE OF
THESE VALUES ON AN INTERIM BASIS WAS VALIDATED BY CRAVE (04/05/90). THE AGENCY IS AWARE THAT THESE VALUES 00 NOT INCORPORATE CONSIDERABLE
INFORMATION THAT IS NOW AVAILABLE. THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT'S POSITION IS THAT THESE TOXICITY VALUES DO NOT
REFLECT STATE-OF-THE-ART SCIENCE FOR VINYL CHLORIDE. EPA NOW HAS INDIVIDUAL ANIMAL DATA, NOT AVAILABLE WHEN THE ORAL UNIT RISK WAS
CALCULATED, THAT MAY INFLUENCE THIS VALUE. ADDITIONAL INFORMATION THAT MAY BE FACTORED INTO A REVISED QUANTITATIVE TOXICITY VALUE
INCLUDES DATA ON INCREASED SENSITIVITY IN ANIMALS AND DATA ON METABOLISM/PHARMACOKtNETICS. A UNIT RISK FOR AIR THAT
CONSIDERS INFORMATION ON YOUNG AGE EXPOSURE INCREASES THE RISK (I.E , LOWERS THE RISK SPECIFIC DOSE) BY AT LEAST 3-FOLD THE
CONSIDERATION OF METABOLISM PHARMACOKINETICS WILL FURTHER INCREASE THE RISK ONE UNPUBLISHED PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL
PREDICTION RESULTS IN A 100-FOLD INCREASED RISK
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM. IS UPDATED MONTHLY FURTHER INFORMATION: RISK INFORMATION HOTLINE: (513) 569-7254. 3-37
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
ACEPHATE 030560-19-1
010086 CHEVRON CHEMICAL COMPANY. 1982 MRID NO 00105197. AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACEPHATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC
US EPA 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
ACROLEIN 000107-02-8
005001 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACROLEIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC.
US EPA 1992 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
ACRYLAMIDE 000079-06-1
010087 JOHNSON K. S GORZINSKI. KM BODNER. ET AL 1986. CHRONIC TOXICITY AND ONCOGENICITY STUDY ON ACRYLAMIDE INCORPORATED IN THE DRINKING WATER
OF FISCHER 344 RATS DOW CHEMICAL. USA. MIDLAND. MI
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACRYLAMIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1988 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-1
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
ACRYLONITRILE 000107-13-1
005004 BIO/DYNAMICS, INC. 1980. A 24-MONTH ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED IN DRINKING WATER TO FISCHER 344
RATS FINAL REPORT. VOL 1-4 PREPARED BY BIO/DYNAMICS. INC , DIVISION OF BIOLOGY AND SAFETY EVALUATION, EAST MILLSTONE, NJ, UNDER PROJECT
NO 77-1744 (BDN-77-27) FOR MONSANTO COMPANY, ST LOUIS. MO.
BIO/DYNAMICS. INC 1980 A 24-MONTH ORAL TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED TO SPARTAN RATS IN THE DRINKING
WATER, FINAL REPORT. VOL 1 AND 2. PREPARED BY BIO/DYNAMICS. INC., DIVISION OF BIOLOGY AND SAFETY EVALUATION, EAST MILLSTONE. NJ, UNDER
PROJECT NO 77-1745 FOR MONSANTO COMPANY. ST LOUIS, MO
QUAST, JF. CE WADE. CG HUMISTON ET AL 1980. A 2-YEAR TOXICITY AND ONCOGENICITY STUDY WITH ACRYLONITRILE INCORPORATED IN THE DRINKING
WATER OF RATS PREPARED BY THE TOXICOLOGY RESEARCH LABORATORY, HEALTH AND ENVIRONMENTAL RESEARCH, DOW CHEMICAL USA, MIDLAND, MI FOR THE
CHEMICAL MANUFACTURERS ASSOCIATION. WASHINGTON. DC.
US EPA 1983 HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
005003 O'BERG, M 1980 EPIDEMIOLOGIC STUDY OF WORKERS EXPOSED TO ACRYLONITRILE J OCCUR MED. 22- 245-252
US EPA 1983 HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON DC
US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-2
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
ALACHLOR 015972-60-8
010180 STOUT, LD, ET AL. 1983 A CHRONIC STUDY OF ALACHLOR ADMINISTERED IN FEED TO LONG-EVANS RATS. EHL #800218. PROJECT NO. ML-80-186. REPORT
MSL-3282/3284. VOL. I AND II UNPUBLISHED STUDY RECEIVED FEB 28, 1984 UNDER U S EPA REG NO. 524-316. PREPARED BY MONSANTO
ENVIRONMENTAL HEALTH LABORATORY (EHL). SUBMITTED BY MONSANTO CO . WASHINGTON. DC CDL'252496-7.
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALACHLOR. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1992. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ALACHLOR PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
ALDRIN 000309-00-2
005006 EPSTEIN. SS. 1975. THE CARCINOGENICITY OF DIELDRIN. PART I. SCI TOTAL ENVIRON 4: 1-52.
NCI (NATIONAL CANCER INSTITUTE). 1977 BIOASSAYS OF ALDRIN AND DIELDRIN FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO
21 NCI-C6-TR-66 DHEW PUBLICATION NO (NIH) 78-821.
DAVIS, KJ, AND OG FITZHUGH. 1962 TUMORIGENIC POTENTIAL OF ALDRIN AND DIELDRIN FOR MICE TOXICOL APPL PHARMACOL. 4 187-189
DAVIS. KJ 1965. PATHOLOGY REPORT ON MICE FOR ALDRIN. DIELDRIN. HEPTACHLOR. OR HEPTACHLOR EPOXIDE FOR TWO YEARS. INT FOOD DRUG ADMIN.
US EPA 1986. CARCINOGENICITY ASSESSMENT OF ALDRIN AND DIELDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
CARCINOGEN ASSESSMENT GROUP. WASHINGTON, DC
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
ALLYL CHLORIDE 000107-05-1
010181 US EPA 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-3
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
ANILINE 000062-53-3
010088 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY) 1982. 104-WEEK CHRONIC TOXICITY STUDY IN RATS. ANILINE HYDROCHLORIDE. FINAL REPORT
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANILINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONHENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
ARAHITE 000140-57-8
010206 OSER BL, AND M OSER 1962 2-{P-TERT~BUTYLPHENQXY)ISOPRQPYL 2-CHLOROETHYL SULFITE (ARAMITE). II. CARCINOGENICITY TOX1COL APPL PHARMACOL
4 70-88,
POPPER H, SS STEINBERG, BL OSER, AND M OSER. 1960 THE CARCINOGENIC EFFECT OF ARAMITE IN RATS. CANCER, 13(5)- 1035-1046
US EPA, 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ARAMITE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH, FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-4
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
ARSENIC, INORGANIC 007440-38-2
005007 BROWN. CC AND KC CHU 1983 APPROACHES TO EPIDEMIOLOGIC ANALYSIS OF PROSPECTIVE AND RETROSPECTIVE STUDIES: EXAMPLE OF LUNG CANCER AND
EXPOSURE TO ARSENIC IN: RISK ASSESSMENT PROC SIMS CONFERENCE ON ENVIRONMENTAL EPIDEMIOLOGY. JUNE 28-JULY 2. 1982, ALTA UT. SIAM
PUBLICATION
BROWN. CC AND KC CHU 1983 IMPLICATIONS OF THE MULTISTAGE THEORY OF CARCINOGENESIS APPLIED TO OCCUPATIONAL ARSENIC EXPOSURE. J NAT
CANCER INST. 70. 455-463.
LEE-FELDSTEIN. A 1983 ARSENIC AND RESPIRATORY CANCER IN MAN. FOLLOW-UP OF AN OCCUPATIONAL STUDY IN' ARSENIC: INDUSTRIAL. BIOMEDICAL,
AND ENVIRONMENTAL PERSPECTIVES. W LEDERER AND R FENSTERHEIM. EDS. VAN NOSTRANO REINHOLD. NEW YORK.
BROWN. CC AND KC CHU 1983. A NEW HETHOD FOR THE ANALYSIS OF COHORT STUDIES: IMPLICATIONS OF THE MULTISTAGE THEORY OF CARCINOGENESIS
APPLIED TO OCCUPATIONAL ARSENIC EXPOSURE ENVIRON HEALTH PERSP. 50: 293-308.
HIGGINS, I 1982 ARSENIC AND RESPIRATORY CANCER AMONG A SAMPLE OF ANACONDA SMELTER WORKERS REPORT SUBMITTED TO THE OCCUPATIONAL SAFETY
HEALTH ADMINISTRATION IN THE COMMENTS OF THE KENNECOTT MINERALS ON THE INORGANIC ARSENIC RULE MAKING, EXHIBIT 203-5
ENTERLINE. PE AND GM MARSH 1982 CANCER AMONG WORKERS EXPOSED TO ARSENIC AND OTHER SUBSTANCES IN A COPPER SMELTER AM J EPIDEMIOL 116.
895-911.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR ARSENIC PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON DC
US EPA 1994 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK
010925 TSENG WP 1977 EFFECTS AND DOSE RESPONSE RELATIONSHIPS OF SKIN CANCER AND BLACKFOOT DISEASE WITH ARSENIC ENVIRON HEALTH PERSPECT. 19
108-119
TSENG WP, HM CHU. SW HOU, ET AL 1968 PREVALENCE OF SKIN CANCER IN AN EMDEMIC AREA OF CHRONIC ARSENICISM W TAIWAN. J NATL CANCER
INST. 40: 453-463.
US EPA. 1994 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-5
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
ASBESTOS 001332-21-4
005010 NTP (NATIONAL TOXICOLOGY PROGRAM), 1985 TOXICOLOGY AND CARCINOGENESIS STUDIES Of CHRYSOTILE ASBESTOS (CAS NO 1200-29-5) IN F344/N RATS
(FEED STUDIES). TECHNICAL REPORT SERIES NO 295
US EPA. 1988 DRINKING WATER CRITERIA DOCUMENT FOR ASBESTOS 'PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC
US EPA 1988 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
005919 US EPA 1986 AIRBORNE ASBESTOS HEALTH ASSESSMENT UPDATE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE
PARK, NC EPA 600/8-84/Q03F.
US EPA. 1988. CARCINOGEN RISK ASSESSHENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
ATRAZINE 001912-24-9
010380 CIBA-GEIGY. 1986. TWO-YEAR FEEDING STUDY IN THE RAT. CONDUCTED BY AMERICAN BIOGENICS CORP MRID NO 262714-262727 AVAILABLE FROM EPA
WRITE TO F01. EPA. WASHINGTON, DC 20460
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ATRAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1990 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
AZOBENZENE 000103-33-3
010089 NCI (NATIONAL CANCER INSTITUTE) 1979 BIOASSAY OF AZOBENZENE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECHNICAL REPORT SERIES
NO 154 US DHEW PUBL NO (NIH) 79-1710 P 112.
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AZOBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA, 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-6
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
BENZENE 000071-43-2
005011 WONG, 0. RW MORGAN AND MD WHORTON. 1983. COMMENTS ON THE NIOSH STUDY OF LEUKEMIA IN BENZENE WORKERS. TECHNICAL REPORT SUBMITTED TO GULF
CANADA, LTD. BY ENVIRONMENTAL HEALTH ASSOCIATES. AUGUST 31. CITED IN US EPA. 1985.
OTT. MG. JC TOWNSEND. WA FISHBECK AND RA LANGNER 1978 MORTALITY AMONG WORKERS OCCUPATIONALLY EXPOSED TO BENZENE. ARCH ENVIRON HEALTH.
33: 3-10.
RINSKY. RA. RJ YOUNG AND AB SMITH. 1981 LEUKEMIA IN BENZENE WORKERS. AM J IND MED 2. 217-245.
US EPA. 1987. MEMORANDUM FROM J ORME HEB. CSD/OOW TO C. VOGT. JUNE. 1987. CRITERIA AND STANDARDS DIVISION. ODW.
US EPA. 1985. INTERIM QUANTITATIVE CANCER UNIT RISK ESTIMATES DUE TO INHALATION OF BENZENE. OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON, DC. OFFICE OF AIR QUALITY PLANNING AND STANDARDS. WASHINGTON. DC
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
BENZIDINE 000092-87-5
005014 ZAVON. MR, U HOEGG AND E BINGHAM 1973 BENZIDINE EXPOSURE AS A CAUSE OF BLADDER TUMORS ARCH ENVIRON HEALTH. 27 1-73
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR BENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON. DC
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR BENZIDINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
BENZOTRICHLORIDE 000098-07-7
010092 FUKUDA K. H METSUSHITA AND K TAKEMOTO 1978 CARCINOGENICITY OF BENZOTRICHLORIDE BY THE ORAL ROUTE OF ADMINISTRATION (J-4774) IN- PROC
52ND ANN MEET JAPANESE INDUSTRIAL HEALTH ASSOC TSCA 8E SUBMISSION DOCUMENT NO 88-8000360. FICHE #204867. P 516-517.
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZOTRICHLORIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-7
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
BENZO[A]ANTHRACENE 000056-55-3
010182 REFER TO IRIS
US EPA 1990, CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
BENZQ[A]PYRENE 000050-32-8
010508 NEAL J. RH RIGDON 1967. GASTRIC TUMORS IN MICE FED BENZO[A]PYRENE A QUANTITATIVE STUDY TEX REP BIOL MED 25 553
US EPA 1991 DRINKING WATER CRITERIA DOCUMENT FOR POLYCYCLIC AROMATIC HYDROCARBONS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, FOR THE OFFICE OF WATER, WASHINGTON, DC.
US EPA 1991 DRINKING WATER CRITERIA DOCUMENT FOR POLYCYCLIC AROMATIC HYDROCARBONS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON, DC.
BENZG[6]FLUGRANTHENE 000205-99-2
010183 REFER TO IRIS.
US EPA 1990 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
BENZQ[K]FLUQRANTH£NE 000207-08-9
010090 REFER TO IRIS
US EPA 1990 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
BENZYL CHLORIDE 000100-44-7
010093 LIJINSKI U 1986 CHRONIC BIOASSAY OF BENZYL CHLORIDE IN F344 RATS AND (C57BL/6J X BALB/OF1 MICE J NATL CANCER INST. 76- 1231-1236
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZYL CHLORIDE, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
BERYLLIUM 007440-41-7
005018 SCHROEDER. HA AND M MITCHNER 1975 LIFE-TIME STUDIES IN RATS EFFECTS OF ALUMINUM. BARIUM. BERYLLIUM AND TUNGSTEN. J NUTR 105. 421-427
US EPA 1991. DRINKING WATER CRITERIA DOCUMENT FOR BERYLLIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC
US EPA 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
005017 WAGONER. JK. PF INFANTE AND DL BAYL1SS. 1980. BERYLLIUM: AN ETIOLOG1C AGENT IN THE INDUCTION OF LUNG CANCER. NONNEOPLASTIC RESPIRATORY
DISEASE. AND HEART DISEASE AMONG INDUSTRIALLY EXPOSED WORKERS ENVIRON RES, 21- 15-34
US EPA. 1987. HEALTH ASSESSMENT DOCUMENT FOR BERYLLIUM PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC
US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
BIS(2-CHLOROETHYL) ETHER 000111-44-4
005076 INNES. JRM. BM ULLAND. MG VALERIO ET AL. 1969. BIOASSAY OF PESTICIDES AND INDUSTRIAL CHEMICALS FOR TUMORIGENICITY IN MICE. A PRELIMINARY
NOTE J NATL CANCER INST 42. 1101-1114.
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR BIS(2-CHLOROETHYL)ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC
US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLOROALKYL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
DC.
US EPA 1985 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
BIS(2-CHLORO-1-METHYLETHYL) ETHER 000108-60-1
005079 NTP (NATIONAL TOXICOLOGY PROGRAM) 1982. CARCINOGENIC BIOASSAY OF BIS(2-CHLORO-1-METHYLETHYL) ETHER (70*) CONTAINING
2-CHLORO-I-METHYLETHYL(2-CHLOROPROPYL) ETHER (30%) IN B6C3F1 MICE (GAVAGE STUDY) NCI CARCINOGEN TECH REP SER NO 239 105 P ALSO PUBL AS
DHHS (NIH) 83-1795
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HALOETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
R3-9
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
BISC2-ETHYLHEXYL) PHTHALATE / (DEHP) 000117-81-7
005120 NTP (NATIONAL TOXICOLOGY PROGRAM) 1982 CARCINOGENESIS BIOASSAY OF DK2-ETHYLHEXYL) PHTHALATE (CAS NO 117-81-7) IN F344 RATS AND B6C3F1
MICE (FEED STUDY) NTP TECH REPORT SER NO 217. NIH/PUB-82-1773. NTP-80-37. NTIS PB82-184011
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACID ALKYL. ARYL AND ALKYL/ARYL ESTERS PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CINCINNATI. OH FOR THE OFFICE OF WATER, WASHINGTON. DC.
BIS(CHLOROMETHYL) ETHER 000542-88-1
005077 KUSCHNER. M. S LASKIN. RT DREW. ET AL 1975. INHALATION CARCINOGENICITY OF ALPHA HALO ETHERS: III. LIFETIME AND LIMITED PERIOD INHALATION
STUDIES WITH BIS(CHLOROMETHYL) ETHER AT 0 1 PPM. ARCH ENVIRON HEALTH. 30(2)' 73-77
US EPA 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
BROMODICHLOROMETHANE 000075-27-4
005148 NTP (NATIONAL TOXICOLOGY PROGRAM) 1987. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMODICHLOROMETHANE (CAS
NO 75-27-4) IN F344 RATS AND B6C3F1 MICE (GAVAGE STUDIES) NTP. RESEARCH TRIANGLE PARK. NC. NTP TR 321 US DEPT OF HEALTH AND HUMAN
SERVICES. PUBLIC HEALTH SERVICE. NATIONAL INSTITUTE OF HEALTH.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
ECAO-CIN-H083
US EPA 1992 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
BROMOETHENE / (VINYL BROMIDE) 000593-60-2
010094 BENYA TJ. WM BASEY. MA DORATO AND PE BERTEAU 1982 INHALATION CARCINOGENICITY BIOASSAY OF VINYL BROMIDE IN RATS TOXICOL APPL PHARMACOL
64 367-379.
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOETHENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
R3-10
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
BROMOFORM 000075-25-2
005150 NTP (NATIONAL TOXICOLOGY PROGRAM). 1988. TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIHALOMETHANE (BROMOFORM) (CAS
NO 75-25-2) IN F344 RATS AND 86C3F1 MICE (GAVAGE STUDIES) NTP-TR 350.
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH, FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
US EPA 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
BUTADIENE, 1,3- 000106-99-0
010477 NTP (NATIONAL TOXICOLOGY PROGRAM). 1984. TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1,3-BUTADIENE (CAS 106-99-0) IN B6C3F1 MICE (INHALATION
STUDIES)
US EPA. 1985 MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF 1,3-BUTADIENE. OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. WASHINGTON.
DC EPA 600/8-85-004F. NTIS-PB86-12507.
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3-BUTADIENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
BUTYL BENZYL PHTHALATE, N- 000085-68-7
005122 NTP (NATIONAL TOXICOLOGY PROGRAM) 1982 CARCINOGENESIS BIOASSAY OF BUTYLBENZYL PHTHALATE (CAS. NO. 85-68-7) IN F344 RATS AND B6C3F1 MICE
(FEED STUDY) NTP TECH REP NTIS PB83-118398. RESEARCH TRIANGLE PARK. NC
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON DC.
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS (PAE)S PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON, DC
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
CADMIUM 007440-43-9
005019 THUN. MJ. TM SCHNORR. A6 SMITH AND WE HALPERIN 1985. MORTALITY AMONG A COHORT OF US CADMIUM PRODUCTION WORKERS: AN UPDATE J NATL CANCER
INST. 74(2): 325-333.
US EPA 1985 UPDATED MUTAGENICITY AND CARCINOGEN!CITY ASSESSMENT OF CADMIUM- TO THE HEALTH ASSESSMENT DOCUMENT FOR CADMIUM.
(MAY 1981, EPA 600/8-81-023) EPA 600/8-83-025F
US EPA. 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
CAPTAFOL 002425-06-1
US EPA, 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAFOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
CAPTAN 000133-06-2
010184 NCI (NATIONAL CANCER INSTITUTE). 1977. BIQASSAY OF CAPTAN FOR POSSIBLE CARCINQGENIC1TY CAS NO. 133-06-2 NTIS PB-273475,
CHEVRON 1982. UNPUBLISHED STUDY.
BIODYNAMICS. 1983. SUBMITTED CHEVRON CHEMICAL CORPORATION. UNPUBLISHED STUDY.
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA. 1988 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
CARBAZOLE 000086-74-8
010096 TSUDA H, A HAZIWARA, M SHIBATA. M OHSIMA AND N ITO, 1982 CARCINOGENIC EFFECT OF CARBAZOLE IN THE LIVER OF (C57BL/6N X C3G/HEN)F1 MICE J
NATL CANCER INST 69: 1383-1389.
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBAZOLE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
CARBON TETRACHLORIOE 000056-23-5
005022 DELIA PORTA. GB. B TERRACINI AND KP SHUBIK. 1961. INDUCTION WITH CARBON TETRACHLORIDE OF LIVER CELL CARCINOMAS IN HAMSTERS J NATL CANCER
INST. 26: 855-863
EDWARDS. J. WE HESTON AND HA DALTON 1942 INDUCTION OF THE CARBON TETRACHLORIDE HEPATOMA IN STRAIN L MICE. J NATL CANCER INST. 3
297-301
NCI (NATIONAL CANCER INSTITUTE). 1976. REPORT ON CARCINOGENESIS BIOASSAY OF CHLOROFORM NTIS PB264-018 NCI-CG-TR-3.
US EPA 1984. HEALTH ASSESSMENT DOCUMENT FOR CARBON TETRACHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH.
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR CARBON TETRACHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
CHLORANIL 000118-75-2
010097 BRL (BIONETICS RESEARCH LABS. INC.) 1968 EVALUATION OF CARCINOGENIC. TERATOGENIC AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES AND
INDUSTRIAL CHEMICALS. VOLUME 1: CARCINOGENIC STUDY NTIS PB 223159.
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORANIL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
CHLORDANE 000057-74-9
005024 VELSICOL 1973. EIGHTEEN MONTH ORAL CARCINOGENIC STUDY IN MICE. DECEMBER 14. 1973 MRID NO. 00067568 AVAILABLE FROM EPA WRITE TO FOI.
EPA, WASHINGTON. DC 20460.
NCI (NATIONAL CANCER INSTITUTE) 1977. BIOASSAY OF CHLORDANE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO 8. ALSO
PUBL AS DHEW PUBL NO (NIH) 77-808
US EPA 1988 UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLORDANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1986 CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
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REFERENCES FOR HEAST TABLE 3: CARCINQGENICITY July 1997
CHLORO-2-METHYLANILINE HYDROCHIORIDE. 4- 003165-93-3
010419 WEISBURGER EK. A8 RUSSFJELD, F HOMBURGER, £T AL 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINQGENICITY. J ENVIRON PATHOL TOXICOL 2. 325-356.
US EPA 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-CHLORO-2-METHYLANILINE AND 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE PREPARED
BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF
SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
CHLORO-2-METHYLANILINE, 4- 000095-69-2
010098 WEISBURGER EK, AB RUSSFIELD. F ET AL 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINGGENICITY. J ENVIRON PATHOL TOXICOL. 2- 325-356.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-CHLORO-2-METHYLANILINE AND 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE PREPARED
BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF
SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
CHLOROBENZILATE 000510-15-6
010848 BRL (BIONETICS RESEARCH LABORATORIES) 1968 EVALUATION OF CARCINOGENIC, TERATOGENIC AND MUTAGENIC ACTIVITIES OF SELECTED AND INDUSTRIAL
CHEMICALS I. CARCINOGENIC STUDY. PREPARED FOR NATIONAL CANCER INSTITUTE, REPORT NO NCI DCCP-C6 1973-1-1. NTIS PB-223-157. P 17. 27-31,
35, 39. 56-57. 68.
US EPA 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROBENZILATE. BY THE OFFICE OF HEATH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
CHLOROFORM 000067-66-3
005036 JORGENSON. TA, EF MEIERHENRY. CJ RUSHBROOK ET AL. 1985 CARCINOGENICITY OF CHLOROFORM IN DRINKING WATER TO MALE OSBORNE-MENDEL RATS AND
- FEMALE B6C3F1 MICE FUND APPL TOXICOL(USA). 5(4) 760-769
US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
005035 NCI (NATIONAL CANCER INSTITUTE). 1976 REPORT ON CARCINOGENESIS BIOASSAY OF CHLOROFORM. NTIS PB264-018.
US EPA 1988 UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC.
US EPA 1985 HEALTH ASSESSMENT DOCUMENT FOR CHLOROFORM PREPARED BY THE OFFICE OF HEALTH AND BENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC.
US EPA. 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
CHLOROMETHANE 000074-87-3
005038 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY), 1981 FINAL REPORT ON 24-MONTH INHALATION STUDY ON METHYL CHLORIDE PREPARED BY
BATTELLE-COLUMBUS LABORATORIES. COLUMBUS. OH DECEMBER 31.
NIOSH (NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH) 1984 CARCINOGENIC RISK ASSESSMENT FOR OCCUPATIONAL EXPOSURE TO
MONOHALOMETHANES NTIS PB85-111623.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL CHLORIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR CHLOROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC
CHLOROMETHYL METHYL ETHER 000107-30-2
005081 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HALOETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
CHLORONITROBENZENE. 0- 000088-73-3
010099 WEISBURGER EK. AB RUSSFIELD. F HOMBURGER, ET AL 1978 TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGEN1CITY J ENVIRON PATHOL TQX1CQL 2 325-356
US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORON1TROBENZENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
CHLORONITROBENZENE, P- 000100-00-5
010100 WEISBURGER EK, AB RUSSFIELD, F HOMBURGEft, ET AL 1978 TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENIC1TY. J ENVIRON PATHOL TOXICOL. 2 325-356,
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITR08ENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
CHLOROTHALONIL 001897-45-6
010384 IRDC 1985 TUMORIGEN1CITY STUDY IN RATS CHLOROTHALONIL Q99-5TX-8Q-234-Q08
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORQTHALONIL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
CHROHIUM(VI) 018540-29-9
005091 MANCUSO. TF 1975 INTERNATIONAL CONFERENCE ON HEAVY METALS IN THE ENVIRONMENT. TORONTO, CANADA. OCT 27-31 CITED IN US EPA, 1984
US EPA. 1984 HEALTH EFFECTS ASSESSMENT FOR HEXAVALENT CHROMIUM ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE
OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC
US EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR CHROMIUM PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE US ENVIRONMENTAL PROTECTION AGENCY. RESEARCH TRIANGLE PARK. NC
US EPA. 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
CHRYSENE 000218-01-9
010185 REFER TO IRIS
US EPA. 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
COKE OVEN EMISSIONS 008007-45-2
005039 HAZUMDAR S, C REDMOND, W SOLLECITO AND N SUSSMAN. 1975 AN EPIDEMIOLOGICAL STUDY OF EXPOSURE TO COAL-TAR-PITCH VOLATILES AMONG COKE OVEN
WORKERS. APCA J 25(4} 382-389
LAND, CE. 1976 PRESENTATION AT OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION HEARINGS ON COKE OVEN STANDARDS.
US EPA. 1984 CARCINOGEN ASSESSMENT OF COKE OVEN EMISSIONS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CARCINOGEN
ASSESSMENT GROUP, WASHINGTON, OC
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
CREOSOTE, COAL TAR 008001-58-9
005042 REFER TO IRIS.
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
CRESOL, M- / (3-METHYLPHENOL) 000108-39-4
010187 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CRESOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
CRESOL, 0- / (2-METHYLPHENQL) 000095-48-7
010186 US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CRESOLS BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONBENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
CRESOL, P- / (4-METHYLPHENOL) 000106-44-5
010188 US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CRESOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-17
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
CROTONALDEHYDE 000123-73-9
010190 CHUNG. FL, T TAMAKA. SS HECHT 1986. INDUCTION OF LIVER TUMORS IN F344 RATS 8Y CROTONALDEHYDE CANCER RES. 46: 1285-1289
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CROTONALDEHYDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
US EPA. 1991 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
CYANAZINE 021725-46-2
010944 BOGDANFFY MS 1990. COMBINED CHRONIC TOXICITY/ONCOGENICITY STUDY WITH CYANAZINE (INR-1957) 2-YEAR FEEDING STUDY IN RATS PREPARED BY E I
DU PONT DE NEMOURS AND CO
US EPA. 1993 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
ODD 000072-54-8
010291 TOMATIS. L. V TURUSOV. RT CHARLES AND M BOICCHI 1974 EFFECT OF LONG-TERM EXPOSURE TO l,l-DICHLORO-2,2-B!S{P-CHLQROPHENYL)ETHYLENE. TO
l,l-D!CHLORO-2,2-B!S(P-CHLQROPH£NYL)ETHANE, AND TO THE TWO CHEMICALS COMBINED ON CF-1 MICE. J NATL CANCER INST 52(3)- 883-891
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
DOE 000072-55-9
010292 TOMATIS, L. V TURUSOV, RT CHARLES AND M BOICCHI 1974 EFFECT OF LONG-TERM EXPOSURE TO l.l-DICHLORO-2.2-BIS(P-CHLOROPHENYL)ETHYLENE, TO
l,l-DICHLORO-2,2-BIS(P-CHLOROPHENYL)ETHANE. AND TO THE TWO CHEMICALS COMBINED ON CF-1 MICE J NATL CANCER INST 52(3)- 883-891
NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF DDT. TDE AND P,P'-DDE FOR POSSIBLE CARCINOGENICITY. NCI REPORT NO 131. DHEW PU8L NO
(NIH) 78-1386
ROSSI L, 0 BARBIERI. M SANGUINETI, JRP CABRAL. P BRUZZI AND L SANTI. 1983 CARCINOGENICITY STUDY WITH TECHNICAL-GRADE DDT AND DDE IN
HAMSTERS. CANCER RES. 43- 776-781.
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
DDT 000050-29-3
005044 US EPA 1986. THE CARCINOGEN ASSESSMENT GROUP'S EVALUATION OF THE CARCINOGEN I CITY OF DICOFOL (KEITHANE). DDT. DDE. AND ODD (TDE).
PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP, WASHINGTON. DC. FOR THE HAZARD EVALUATION
DIVISION. OFFICE OF PESTICIDE PROGRAMS. OFFICE OF PESTICIDES AND TOXIC SUBSTANCES. WASHINGTON. DC.
US EPA 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR DDT PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC EPA 540/1-86-026.
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
DECABROMODIPHENYL ETHER 001163-19-5
010102 US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DECABROMODIPHENYL OXIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
DIALLATE 002303-16-4
010103 BRL (BIONETICS RESEARCH LABS. INC.) 1968. EVALUATION OF CARCINOGENIC. TERATOGENIC. AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES AND
INDUSTRIAL CHEMICALS. VOL 1. CARCINOGENIC STUDY PREPARED FOR NATIONAL CANCER INSTITUTE. US DEPARTMENT OF COMMERCE. WASHINGTON, DC. NTIS
PB-223159
INNES. JRM. BM ULLAND. MG VALERIO. ET AL 1969. BIOASSAY OF PESTICIDES AND INDUSTRIAL CHEMICALS FOR TUMORIGENICITY IN MICE. A PRELIMINARY
NOTE J NATL CANCER INST. 42' 1101-1114.
US EPA 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIALLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE. WASHINGTON, DC
DIBENZO[A,H]ANTHRACENE 000053-70-3
010191 REFER TO IRIS
US EPA 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-19
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
DIBROMO-3-CHLOROPROPANE, 1,2 000096-12-8
010519 NTP (NATIONAL TOXICOLOGY PROGRAM). 1982, CARCINOGENESIS BIOASSAY OF 1.2-DIBROMO-3-CHLOROPROPANE (CAS NO 96-12-8) IN F344 RATS AND B6C3F1
MICE (INHALATION STUDY). NTP-TR-NO 81-21.
US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION (CRAVE) WORK
010484 HAZELTON LABORATORIES, INC 1977. 104 WEEK DIETARY STUDY IN RATS, 1.2-DIBROMO-3-CHLOROPROPANE (OBCP). FINAL REPORT UNPUBLISHED REPORT
SUBMITTED TO DOW CHEMICAL CO , MIDLAND. MI. OCTOBER 29, 1977.
US EPA. 1988. DRINKING WATER CRITERIA DOCUMENT FOR DIBROMOCHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON DC ECAO-CIN-41Q
US EPA. 1988 ASSESSMENT OF THE CARCINOGENIC POTENTIAL OF 1.2-DIBROMQ-3-CHLQROPROPANE (DBCP) PREPARED BY THE CARCINOGEN ASSESSMENT
GROUP. AVAILABLE THROUGH RCRA/SUPERFUND DOCKET
DIBRQHOCHLOROMETHANE 000124-48-1
010891 NTP (NATIONAL TOXICOLOGY PROGRAM) 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLQRQOIBROMOMETHANE (CAS NO 124-48-1) IN F/344/N RATS
AMD B6C3F1 MICE NTP TECH REP SER NO 282, DHHS NO NIH 85-2538.
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
US EPA 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
DIBROMOETHANE, 1,2- 000106-93-4
005071 NTP (NATIONAL TOXICOLOGY PROGRAM) 1982 CARCINOGENESIS BIOASSAY OF 1,2-DIBROMOETHANE (ETHYLENE DIBROMIDE) (CAS NO 106-93-4) IN F344 RATS
AND B6C3F1 MICE (INHALATION STUDY). NTP TECH REP SER NO 210. NIH PUBL NO 82-1766
US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
005818 NCI (NATIONAL CANCER INSTITUTE) 1978 BIOASSAY OF 1.2-DIBROMOETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS REPORT SERIES NO
86 PB-288-428
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE DIBROMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,2-DIBROMOETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC.
US EPA. 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
OICHLORO-2-BUTENE, 1,4- 000764-41-0
005053 El DUPONT DE NEMOURS AND CO. 1986. LONG-TERM INHALATION STUDY WITH 1.4-DICHLOROBUTENE-2 (DCB) IN RATS FINAL REPORT OTS 8(E) FICHE
0509754
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DICHLOROBUTENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
DICHLOROBENZENE. 1,4- 000106-46-7
005050 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.4-DICHLOROBENZENE IN F344/N RATS AND B6C3F1 MICE --
GALLEY DRAFT. US OHHS, PHS, NIH TECH REP SER NO 319.
CONTAMINANTS. 1987. FR (JULY 8) 52: 25690-25717
OICHLOROBENZIDINE, 3,3'- 000091-94-1
005815 STULA. EF. H SHERMAN. JA ZAPP. ET AL. 1975 EXPERIMENTAL NEOPLASIA IN RATS FROM ORAL ADMINISTRATION OF 3.3'-QICHLOROBENZIDINE.
4.4'-METHYLENE-BIS(2-CHLOROANILINE) AND 4.4'-METHYLENE-BIS (2-METHYLANILINE). TOXICOL APPL PHARMACOL. 31 159-175.
US EPA 1988 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
DICHLOROETHANE, 1.1- 000075-34-3
005055 US EPA 1984. HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
DICHLOROETHANE. 1.2- 000107-06-2
005058 NCI (NATIONAL CANCER INSTITUTE) 1978. BIOASSAY OF 1,2-DICHLOROETHANE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO
55. DHEW PUBL NO (NIH) 78-1361.
US EPA 1985 HEALTH ASSESSMENT DOCUMENT FOR 1.2-DICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
WASHINGTON. DC EPA 600/8-84-006F.
US EPA 1985. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
DICHLOROETHYLENE, 1,1- 000075-35-4.
005060 NTP (NATIONAL TOXICOLOGY PROGRAM) 1982 CARCINOGENESIS BIOASSAY Of VINYLIDENE CHLORIDE (CAS NO 75-35-4) IN F344 RATS AND B6C3F1 MICE
(GAVAGE STUDY). NTP TECH REP SER NO 228, DHHS NO NIH 82-1784
US EPA 1985. HEALTH ASSESSMENT FOR VINYL10ENE CHLORIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK. NC
US EPA 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR 1.1-DICHLOROETHYLENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH, FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION (CRAVE) WORK
005059 MALTONI. C. G LEFEMINE. P CHIECO ET AL. 1985 EXPERIMENTAL RESEARCH ON VINYLIDENE CHLORIDE CARCINOGENESIS IN ARCHIVES OF RESEARCH ON
INDUSTRIAL CARCINOGENESIS. VOL 3, C. MALTONI AND M MEHLMAN, EO, PRINCETON SCIENTIFIC PUBLISHERS. PRINCETON. NJ.
US EPA. 1985 HEALTH ASSESSMENT DOCUMENT FOR VINYLIDENE CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK, NC
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
DICHLOROPROPANE, 1,2- 000078-87-5
005062 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 NTP TECHNICAL REPORT ON THE CARCINOGENESIS STUDIES OF 1,2-DICHLORQPROPANE (PROPYLENE
DICHLORIDE) (CAS NO. 78-87-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES), NTP-82-092, NIH PUBL NO 84-2519, NTP TR 263, US DHHS.
PHS. NIH. AUGUST, 1986 DRAFT
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 1,2-DICHLOROPROPANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH, FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
DICHLOROPROPENE, 1.3- / (TELONE II) 000542-75-6
010946 NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF TELONE II IN F344/N RATS AND B6C3F1 MICE US OEPT
HEALTH AND HUMAN SERVICES, TECH REPORT SER NO 269.
US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
US EPA. 1993 REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR 1.3-DICHLOROPROPENE PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON.
DC.
010104 LOMAX LG, WT STOTT, KA JOHNSON. LL CALHOUN. BL YANG AND JF QUAST. 1989. THE CHRONIC TOXIC1TY AND ONCOGENICITY OF INHALED TECHNICAL GRADE
1.3-DICHLOROPROPENE IN RATS AND MICE. FUND APPL TOXICOL 12 418-431
US EPA 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1.3-OICHLOROPROPENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
DIELDRIN 000060-57-1
005816 NCI (NATIONAL CANCER INSTITUTE). 1978 BIOASSAYS OF ALDRIN AND DIELDRIN FOR POSSIBLE CARCINOGENICITY NATIONAL CANCER INSTITUTE
CARCINOGEN TECH REP SER NO 22 NCI-CG-TR-22 ALSO FUEL AS DHEW PUBL NO (NIH) 78-882
WALKER, AIT. E AND DE STEVENSON, 1972 THE TOXICOLOGY OF DIELDRIN (HEOD)- I LONG-TERM ORAL TOXICITY STUDIES IN MICE FOOD COSMET
TOXICOL. II 415-432
MEIERHENREY, EF, BH REUBER. ME GERSHWIN ET AL 1983 DIELDRIN INDUCED MALLORY BODIES IN HEPATIC TUMORS OF MICE OF DIFFERENT STRAINS
HEPATOLOGY 3 90-95
TENNEKES, HA, AS WRIGHT, KM OIX AND JH KOEMAN. 1981 EFFECTS OF DIELDRIN. DIET AND ON FUNCTION AND TUMOR INCIDENCE IN
LIVERS OF MALE CF-1 MICE CANCER RES 41 3615-3620
THORPE, E AND AIT WALKER 1973 THE TOXICOLOGY OF DIELDRIN (HEOD). II COMPARATIVE LONG-TERM ORAL TOXICITY STUDIES IN MICE WITH DIELDRIN,
DDT, PHENOBARBITONE, BETA-BHC AND GAMMA-BHC FOOD COSMET TOXICOL. 11: 433-442
DAVIS, KJ 1965. PATHOLOGY REPORT ON MICE FED ALDRIN, DIELDRIN, HEPTACHLOR OR HEPATOCHLOR EPOXIDE FOR TWO YEARS INTERNAL FDA
TO OR AO LEHMAN. JULY 19
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR DIELDRIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
OIETHYLSTILBESTROL 000056-53-1
010485 GASS. ET AL 1964 CARCINOGENIC DOSE-RESPONSE CURVE TO ORAL DIETHYLSTIL8ESTEROL J NATL CANCER INST 33 971-977
US EPA 1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF OIETHYLSTILBESTERQL, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON
DC
DIMETHOXYBENZIDINE, 3,3'- 000119-90-4
010106 SELLAKUMAR AR. R MONTESANO AND A SAFFIOTI 1969 AROMATIC AMINES CARCINOGENICITY IN HAMSTERS PROC AM ASSOC CANCER RES 10 78
OSHA/NIOSH (OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION/NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH) 1980 HEALTH HAZARD,
ALERT BENZIDINE. 0-TOLID1NE AND 0-DIANISIOINE BASED DYES. DHHS (NIOSH) PUBL NO 81-106
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 3,3'-DIMETHOXYBENZIDINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
DIMETHYLANILINE HYDROCHLORIDE, 2.4- 021436-96-4
010108 WEISBURGER EK. AB RUSSFIELD. F HOMBURGER. ET AL. 1978 TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2 325-356
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-DIMETHYLANILINE AND 2.4-DIMETHYLANILINE HYDROCHLORIDE PREPARED BY THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE. WASHINGTON. DC.
DIMETHYLANILINE, 2,4- 000095-68-1
010107 WEISBURGER EK. AB RUSSFIELD. F HOMBURGER. ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM
TOXICITY OR CARCINOGENICITY. 0 ENVIRON PATHOL TOXICOL 2 325-356
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-DIMETHYLANILINE AND 2.4-DIMETHYLANILINE HYDROCHLORIDE PREPARED BY THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE. WASHINGTON. DC.
DIMETHYLBENZIDINE. 3,3'- 000119-93-7
010109 GRISWOLD DP JR. AE CASEY. EK WEISBURGER AND JH WEISBURGER. 1968. THE CARCINOGENICITY OF MULTIPLE INTRA-GASTRIC DOSES OF AROMATIC AND
HETEROCYCLIC NITRO OR AMINO DERIVATIVES IN YOUNG FEMALE SPRAGUE-DAWLEY RATS CANCER RES. 28(5) 924-933
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 3.3'-DIMETHYLBENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
DIMETHYLHYDRAZINE, 1,2- 000540-73-8
010962 TOTH B AND K PATEL 1982. CARCINOGENICITY DOSE RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF 1.2-DIMETHYL HYDRAZINE DIHYDROCHLORIDE IN
MICE I LIGHT AND TRANSMISSION ELECTRON MICROSCOPE STUDY OF COLONIC NEOPLASMS. AM J PATH 84 69-86
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2-DIMETHYLHYDRAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC
US EPA. 1989. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1.2-DIMETHYLHYDRAZINE PREPARED BY THE CARCINOGEN ASSESSMENT GROUP, OFFICE
OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND
REMEDIAL RESPONSE AND OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
OIMETHYLSULFATE 000077-78-1
010112 US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYL SULFATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
DINITROTOLUENE, 2,4- 000121-14-2
005066 ELLIS. HV. SH HAGEUSEN. OR JODGSON ET AL 1979 MAMMALIAN TOXICITY OF MUNITIONS COMPOUNDS PHASE III EFFECTS OF LIFETIME EXPOSURE. PART
I. 2.4-DINITROTOLUENE. NTIS AD-A077692 281 P.
US EPA 1987. HEALTH EFFECTS ASSESSMENT FOR 2,4- AND 2.6-DINITROTOLUENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC.
US EPA 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
DINITROTOLUENE, 2,6- 000606-20-2
005068 ELLIS HV. SH HAGUESEN, JR JODGSON, ET AL 1979. MAMMALIAN TOXICITY OF MUNITION COMPOUNDS PHASE III. EFFECTS OF LIFETIME EXPOSURE PART
I 2.^DINITROTOLUENE NTIS AD-A077692. 281 P
US EPA 1987 HEALTH EFFECTS ASSESSMENT FOR 2,4- AND 2.6-D1N1TROTOLUENES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC,
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
DIOXANE, 1,4- 000123-91-1
010298 NCI (NATIONAL CANCER INSTITUTE) 1978 BIOASSAY OF 1,4-DIOXANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINQGENESIS TECH REP SER NO 80 DHEW
PUBLICATION NO (NIH) PB-285-711
US EPA 1988, CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
DIPHENYLHYDRAZINE, 1.2- 000122-66-7
005070 NCI (NATIONAL CANCER INSTITUTE) 1978 BIOASSAY OF HYDRAZOBENZENE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO 92.
DHEW PUBL NO (NIH) 78-1342
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 1.2-OIPHENYLHYDRAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA. 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1,2-DIPHENYLHYDRAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR 1.2-DIPHENYLHYDRAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
DC.
US EPA. 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
DIRECT BLACK 38 001937-37-7
010113 NCI (NATIONAL CANCER INSTITUTE) 1978. 13-WEEK SUBCHRONIC TOXICITY STUDIES ON DIRECT BLUE 6. DIRECT BLACK 38 AND DIRECT BROWN 95 DYES.
NCI CARCINOGENESIS TECH REP SER NO 108. P 127
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT BLACK 38 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
DIRECT BLUE 6 002602-46-2
010114 NCI (NATIONAL CANCER INSTITUTE) 1978. 13-WEEK SUBCHRONIC TOXICITY STUDIES OF DIRECT BLUE 6. DIRECT BLACK 38. AND DIRECT BROWN 95 DYES.
NCI CARCINOGENESIS. TECH REP SER NO. 108. P 127.
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT BLUE 6 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
DIRECT BROWN 95 016071-86-6
010115 NCI (NATIONAL CANCER INSTITUTE). 1978 13-WEEK SUBCHRONIC TOXICITY STUDIES OF DIRECT BLUE 6. DIRECT BLACK 38. AND DIRECT BROWN 95 DYES
NCI CARCINOGENESIS TECH REP SER NO 108 P 127
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT BROWN 95 PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
DIRECT SKY BLUE 6B 002610-05-1
010116 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT SKY BLUE 68. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
EPICHLOROHYDRIN 000106-89-8
010117 LASKIN S. AR SELLAKUMAR, M KL6CHNER, ET AL 1980. INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN NON-INBRED SPRAGUE-DAWLEY RATS J NATL
CANCER INST 65(4): 751-757.
US EPA 1984. HEALTH ASSESSMENT FOR EPICHLOROHYORIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-83-032F NTIS PB85-132363
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPICHLOROHYDRIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
US EPA 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK
010198 KONISHI, T. A KAWABATA, A OENDA, ET AL. 1980. FORESTQMACH TUMORS INDUCED BY ORALLY ADMINISTERED EPICHLOROHYDRIN IN MALE WISTAR RATS.
GANN 71. 922-923.
US EPA. 1984 HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK, NC EPA 600/8-83-032F NTIS PB85-132363,
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPICHLOROHYORIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
US EPA 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
ETHYL ACRYLATE 000140-88-5
010118 NTP (NATIONAL TOXICOLOGY PROGRAM) 1986 CARCINOGENESIS STUDIES OF ETHYL ACRYLATE IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES)
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL ACRYLATE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
ETHYLENE OXIDE 000075-21-8
010421 DUNKELBERG H. 1982 CARCINOGEN!CITY OF ETHYLENE OXIDE AND 1.2-PROPYLENE OXIDE UPON INTRA-GASTRIC ADMINISTRATION TO RATS. BR J CANCER. 46,
924-933
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR OXIRANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
010422 SNELLINGS WM, CS WEIL AND RR MQRONPQT, 1981 FINAL REPORT. ETHYLENE OXIDE, TWO YEAR INHALATION STUDY. SUBMITTED TO THE US ENVIRONMENTAL
PROTECTION AGENCY BY BUSHEY RUN RESEARCH CENTER, PITTSBURGH PA.
US EPA. 1985 HEALTH ASSESSMENT DOCUMENT FOR ETHYLENE OXIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK, NC EPA 600/8-84-009F NTIS PB86-102597
ETHYLENE THIOUREA 000096-45-7
010947 NTP (NATIONAL TOXICOLOGY PROGRAM), 1992 NTP TECHNICAL REPORT ON THE PERINATAL TOXICOLOGY AND CARCINOGENESIS STUDIES OF ETHYLENE THIOUREA
(CAS NO 96-45-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) NTP TR 388 US DEPT OF HEALTH AND HUMAN SERVICES. PUBLIC HEALTH SERVICE.
NATIONAL INSTITUTES OF HEALTH
US EPA. 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
FOLPET 000133-07-3
010120 CHEVRON CHEMICAL COMPANY 1982. CHEVRON STUDY LIFETIME ONCQGENICITY FEEDING STUDY OF PHOLTON TECHNICAL (SX-946. FOLPET) IN CD-I (ICR
DERIVED) MICE. AUGUST 24. SOCIAL STUDY NO 1331
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FOLPET. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC,
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
FORMALDEHYDE 000050-00-0
010121 KERNS ET AL , 1983 CARCINOGENICITY OF FORMALDEHYDE IN RATS AND MICE AFTER LONG-TERM INHALATION EXPOSURE CANCER RES. 43(9) 4382-4392.
US EPA. 1988 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
US EPA 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FORMALDEHYDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
FURAZOLIDONE 000067-45-8
005106 US DHEW. 1976 FUROZOLIQONE (NF-180). NOTICE OF OPPORTUNITY FOR HEARING ON PROPOSAL TO WITHDRAW APPROVAL OF CERTAIN NEW ANIMAL DRUG
APPLICATIONS. FEDERAL REGISTER, 41 19907-19921.
US DHEW 1976. FUROZQLIDONE. NIHYDRAZONE, FURALTADONE, NITROFURAZONE, WITHDRAWAL OF PROPOSALS AND NOTICE OF PROPOSED RULE MAKING FEDERAL
REGISTER 41: 34884-34921.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITROFURANS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
FURIUM 000531-82-8
005108 COHEN, SM. E ERTURK AND GT BRYAN 1970 PRODUCTION OF LEUKEMIA AND STOMACH NEOPLASMS IN SWISS. RF, BALB/C AND C3H FEMALE MICE BY FEEDING
N-(4.5~NITRO-2-FURYL-2-THIAZOLYL)ACETAMIDE. CANCER RES 30(9): 2320-2325
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITROFURANS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
yASHINGTON, DC.
GLYCIDALDEHYDE 000765-34-4
010122 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
US EPA 1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
HEPTACHLOR 000076-44-8
005820 DAVIS K. 1965. PATHOLOGY REPORT ON MICE FED ALDRIN. DIELDRIN. HEPTACHLOR, AND HEPTACHLOR EPOXIDE FOR TWO YEARS. INTERNAL FDA MEMORANDUM
TO DR AJ LEHMAN. JULY 19
NCI (NATIONAL CANCER INSTITUTE) 1977 BIOASSAY OF HEPTACHLOR FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECH REP SER NO 9. DHEW NO
(NIH) 77-809
EPSTEIN. SS. 1976. CARCINOGENICITY OF HEPTACHLOR AND CHLORDANE SCI TOTAL ENVIRON. 6: 103-154.
REUBER. MD 1977 HISTOPATHOLOGY OF CARCINOMAS OF THE LIVER IN MICE INGESTING HEPTACHLOR OR HEPTACHLOR EPOXIDE EXP CELL BIOL. 45.
147-157
US EPA. 1986 CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP. WASHINGTON. DC.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR HEPTACHLOR. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA. 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
HEPTACHLOR EPOXIDE 001024-57-3
010424 DAVIS KJ 1965 PATHOLOGY REPORT ON MICE FED ALDRIN. DIELDRIN. HEPTACHLOR AND HEPTACHLOR EPOXIDE FOR TWO YEARS INTERNAL FDA MEMORANDUM
TO DR. A J LEHMAN JULY 19
VELSICOL CHEMICAL CORPORATION 1973. MRID NO 00062678 AVAILABLE FROM EPA WRITE TO FOI. EPA. WASHINGTON. DC 20460
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
HEXACHLOROBENZENE 000118-74-1
010365 ERTURK E. RW LAMBRECHT. HA PETERS. OJ CRIPPS ET AL 1986. ONCOGENICITY OF HEXACHLROBENZENE IN: HEXACHLROBENZENE: PROC INT SYMP. CR
MORRIS AND JRP CABRAL. ED IARC SCIENTIFIC PUBL NO 77. OXFORD UNIVERSITY PRESS. OXFORD P 417-423
US EPA 1991 DRINKING WATER CRITERIA DOCUMENT FOR HEXACHLOROBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON, DC
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROBENZENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC.
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
HEXACHLOROBUTADIENE 000087- 68-3
005088 KOCIBA, RJ, DG KEYS, GC JERSEY. ET AL 1977 RESULTS OF A2-YEAR CHRONIC TOXICITY STUDY WITH HEXACHLOROBUTADIENE IN RATS AM IND HYG ASSOC
J 38- 589-602.
US EPA 1980 AMBIENT QUALITY CRITERIA FOR HEXACHLOROBUTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
DC
US EPA 1984. HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROBUTAOIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
HEXACHLOROCYCLOHEXANE. ALPHA- 000319-84-6
010123 ITO N, H NAGASAKI. M ARIA, ET AL 1973 H3STOLOG3CAL AND ULTRASTRUCTURAL STUDIES ON THE HEPATOCARCIMOGENICITY OF BENZENE HEXACHLORIDE IN
MICE. J NATL CANCER INST 51 817-826
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
US EPA 1986, CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
HEXACHLOROCYCLOHEXANE, BETA 000319-85-7
010124 THORPE E AND AIT WALKER 1973 TOXICOLOGY OF DIELDRIN (HEOD) II COMPARATIVE LONG-TERM ORAL TOXICITY STUDIES IN MICE WITH DIELORIN. DOT.
PHENOBARBITONE. BETA-HCH AND GAMMA-HCH FOOD COSMET TOXICOL 11 433-442.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
HEXACHLOROCYCLOHEXANE. DELTA- 000319-86-8
010125 ITO N. H NAGASAKI. H AOE. ET AL 1975 BRIEF COMMUNICATION. DEVELOPMENT OF HEPATOCELLULAR CARCINOMAS IN RATS TREATED WITH
BENZENEHEXACHLORIDE. J NATL CANCER INST. 54' 801-805.
ITO N, H NAGASAKI. M ARIA. ET AL. 1973. HISTOLOGICAL AND ULTRASTRUCTURAL STUDIES ON THE HEPATOCARCINOGENICITY OF BENZENE HEXACHLORIDE IN
MICE. J NATL CANCER INST 51. 817-826.
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
HEXACHLOROCYCLOHEXANE, EPSILON- 006108-10-7
010126 GOTO M. M HATTORI. T MIYAGAWA AND M ENOMOTO. 1972 ECOLOGICAL CHEMISTRY. II. HEPATOMA FORMATION IN MICE AFTER ADMINISTRATION OF HIGH
DOSES OF HEXACHLOROCYCLOHEXANE ISOMERS. CHEMOSPHERE 1 279-282.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
US EPA 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
HEXACHLOROCYCLOHEXANE, GAMMA- 000058-89-9
005098 THORPE. E AND AIT WALKER 1973 THE TOXICOLOGY OF DIELDRIN (HEOD) II. COMPARATIVE LONG-TERM ORAL TOXICITY STUDIES IN MICE WITH DIELDRIN.
DDT, PHENOBARBITONE. BETA-BHC AND GAMMA-BHC. FOOD COSMET TOXICOL 11 433-442
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON
DC.
US EPA 1984 HEALTH EFFECTS ASSESSMENT FOR LINDANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH, FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
HEXACHLOROCYCLOHEXANE-TECHNICAL 000608-73-1
010127 MUNIR KM. CS SOMAN AND V SUMATI 1983 HEXACHLOROCYCLOHEXANE-INDUCED TUMORIGENICITY IN MICE UNDER DIFFERENT EXPERIMENTAL CONDITIONS
TUMQRIGENICITY 69. 383-386
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOBEXANES, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
HEXACHLOROETHANE 000067-72-1
005090 NCI (NATIONAL CANCER INSTITUTE) 1978. BIOASSAY OF HEXACHLOROETHANE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO 68.
DHEW NO (NIH) 78-1318.
US EPA. 1989 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR HEXACHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED ETHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS, WASHINGTON.
DC.
US EPA 1987. HEALTH EFFECTS ASSESSHENT FOR HEXACHLOROETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1986. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
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REFERENCES FOR HEAST TABLE 3: CARCIMOGENICITY July 1997
HYDRAZINE 000302-01-2
010129 BIANCIFIORI C. 1970. HEPATOMAS IN CBA/CB/SE MICE AND LIVER LESIONS IN GOLDEN HAMSTERS INDUCED BY HYDRAZINE SULFATE J NATL CANCER INST
44: 943.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE AND HYDRAZINE SULFATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC
US EPA 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
010128 MACEWEN JD. EH VERNOT. CC HAUN. ER KINKEAO AND A HALL, III. 1981 CHRONIC INHALATION TOX1CITY OF HYDRAZINE: ONCOGENIC EFFECTS AIR FORCE
AEROSPACE MEDICAL RESEARCH LABORATORY. WRIGHT-PATTERSON AIR FORCE BASE. OH
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE AND HYDRAZINE SULFATE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
US EPA. 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
HYDRAZINE SULFATE 010034-93-2
010131 BIANCIFIORI C. 1970 HEPATOMAS IN CBA/CB/SE MICE AND LIVER LESIONS IN GOLDEN HAMSTERS INDUCED BY HYDRAZINE SULFATE J NATL CANCER INST
44: 943
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE AND HYDRAZINE SULFATE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
010130 MACEWEN JD. EH VERNOT. CC HAUN. ER KINKEAD AND A HALL. Ill 1981. CHRONIC INHALATION TOXICITY OF HYORAZINE: ONCOGENIC EFFECTS AIR FORCE
AEROSPACE MEDICAL RESEARCH LABORATORY. WRIGHT-PATTERSON AIR FORCE BASE. OH
US EPA 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HYDRAZINE AND HYDRAZINE SULFATE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC
US EPA. 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-35
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
INDENO[1,2,3-CD]PYRENE 000193-39-5
010192 REFER TO IRIS
US EPA 1990 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
ISOPHORONE 000078-59-1
005094 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 TOXICOLOGY AND CARCINOGENS IS STUDIES OF ISOPHORONE (CAS NO 78-59-1) IN F344/N RATS AND B6C3F1
MICE (GAVAQE STUDIES). NTP TECH REP SER NO 291, OHHS (NIH)86-2547
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOPHQRONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR ISOPHORONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA. 1992 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
LEAD 007439-92-1
005096 US EPA. 1989 EVALUATION OF THE POTENTIAL CARCINOGENICITY OF LEAD AND LEAD COMPOUNDS PREPARED BY THE CARCINOGEN ASSESSMENT GROUP, OFFICE
OF HEALTH AND ENVIRONMENTAL ASSESSMENT, WASHINGTON OC FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON DC
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR LEAD. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA
AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC.
US EPA 1988 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
LINURON 000330-55-2
010383 REFER TO IRIS.
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-36
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
MERCURIC CHLORIDE 007487-94-7
010971 NTP (NATIONAL TOXICOLOGY PROGRAM) 1993 TOXICOLOGY AND CARCINOGENESIS STUDIES OF MERCURIC CHLORIDE (CAS NO 7487-94-7) IN F344 RATS
AND B3C3F1 MICE (GAVAGE STUDIES) NTP TECHNICAL REPORT SERIES NO. 408. NATIONAL TOXICOLOGY PROGRAM, U.S DEPARTMENT OF HEALTH AND HUMAN
SERVICES, PUBLIC HEALTH SERVICE. NATIONAL INSTITUTES OF HEALTH. RESEARCH TRIANGLE PARK, NC
U S. EPA. 1995 MERCURY STUDY REPORT TO CONGRESS. OFFICE OF RESEARCH AND DEVELOPMENT, WASHINGTON, DC. EXTERNAL REVIEW DRAFT
EPA/600/P-94/002A5.
U.S EPA. 1994 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
MERCURY. ELEMENTAL 007439-97-6
010973 CRAGLE, D L . D.R. HOLLIS, J.R QUALTERS. W G TANKERSLEY AND S A FRY 1984. A MORTALITY STUDY OF MEN EXPOSED TO ELEMENTAL MERCURY
J OCCUP MED 26(11). 817-821.
U.S EPA 1995 MERCURY STUDY REPORT TO CONGRESS OFFICE OF RESEARCH AND DEVELOPMENT, WASHINGTON. DC. EXTERNAL REVIEW DRAFT
EPA/600/P-94/OOAb.
U.S. EPA. 1994 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
METHOXY-5-NITROANILINE, 2- 000099-59-2
010132 NCI (NATIONAL CANCER INSTITUTE) 1978. BIOASSAY OF 5-NITRO-O-ANISIDINE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO.
127. 123 P.
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXY-5-NITROANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
METHYL-5-NITROANILINE, 2- 000099-55-8
010140 NCI (NATIONAL CANCER INSTITUTE) 1978 BIOASSAY OF 5-NITRO-O-TOLUIDINE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGEN TECH REP SER NO. 107.
102 P.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYL-5-NITROANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC
R3-37
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITV July 1997
METHYLANILINE HYDROCHLORIDE, 2- 000636-21-5
010134 HECHT SS, A EL-BOYOUMY. A RMNSON AND E FIALA 1982 COMPARATIVE CARCINOGENICITY OF 0-TOLUIOINE HYDROCHLORIOE AND 0-NITRQSOTOLUF.NE IN
p-344 RATS. CANCER LETT 16(1)- 103-108.
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYLANILINE AND 2-METHYLANILINE HYDROCHLORIOE PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
METHYLANILINE, 2- 000095-53-4
010133 HECHT SS, A EL-BOYOUMY. A RIVENSON AND E FIALA. 1982. COMPARATIVE CARCINOGEN1CITY OF 0-TOLUIDINE HTOROCHLORIOE AND 0-NITRQTQLUENE IN
F-344 RATS CANCER LETT 16(1). 103-108.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYLAN1LINE AND 2-METHYLANILINE HYDROCHLORIDE. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON, DC.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIOINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
METHYLENE CHLORIDE / (DICHLOROMETHANE) 000075-09-2
005100 NCA (NATIONAL COFFEE ASSOCIATION) 1983. TWENTY-FOUR MONTH ONCOGENICITY STUDY OF METHYLENE CHLORIDE IN MICE. PREPARED BY HAZELTON
LABORATORIES. AMERICA INC, VIENNA, VA.
NTP (NATIONAL TOXICOLOGY PROGRAM). 1986 TOXICOLOGY AND CARCINOGENESIS STUDIES Of OICHLOROMETHANE {METHYLENE CHLORIDE) (CAS NO 75-09-2)
IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) NTP TECH REP SER NO 306. DWS (NIH) 86-2562
US EPA. 1985 ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR DICHLOROMETHANE (METHYLENE CHLORIDE) UPDATED CARCINOGENICITY ASSESSMENT OF
DICHLOROMETHANE (METHYLENE CHLORIDE) OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. CARCINOGEN ASSESSMENT GROUP, WASHINGTON, OC
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
005904 NTP (NATIONAL TOXICOLOGY PROGRAM), 1986 TOXICOLOGY AND CARCINOGENESIS STUDIES OF OICHLOROMETHANE (METHYLENE CHLORIDE) (CAS NO 75-09-2)
IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES). NTP TECH REP SER NO 306, DHHS (NIH) 86-2562
US EPA 1989 UPDATED HEALTH EFFECTS ASSESSMENT FOR METHYLENE CHLORIDE BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON. DC
US EPA. 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-38
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REFERENCES FOR HEA5T TABLE 3: CARCINOGENICITY July 1997
METHYLENE-BIS(2-CHLOROANILINE), 4.4'- 000101-14-4
010425 KOMMINENI C. DH GROTH. IJ FROCKT. RW VOELKER AND RP STANOVICK. 1979 DETERMINATION OF THE TUMORIGENIC POTENTIAL OF
METHYLENE-BIS-ORTHO-CHLOROANILINE. J ENVIRON PATH TOXICOL 2(5)' 149-171
STULA EF. H SHERMAN, JP ZAPP. JR AND JW CLAYTON. 1975 EXPERIMENTAL NEOPLASIA IN RAT FROM ORAL ADMINISTRATION OF 3.3-DICHLOROBENZIDINE.
4.4-METHYLENE-BIS(2-CHLOROANILINE) AND 4.4-METHYLENE-BIS(2-METHYLANILINE) TOXICOL APPL PHARMACOL. 31(1) 159-176
US EPA. 1990 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4.4-METHYLENE-BIS(2-CHLOROANILINE) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
METHYLENE-BIS(N,N'-DIMETHYL)ANILINE. 4,4'- 000101-61-1
010137 NCI (NATIONAL CANCER INSTITUTE). 1979 BIOASSAY OF 4.4'-METHYLENE-BIS(N.N'-DIMETHYDBENZENAMINE FOR POSSIBLE CARCINOGENICITY NCI
CARCINOGEN TECH REP SER NO. 186. CAS 101-61-1
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4.4'-METHYLENE-BIS(N,N'-DIMETHYDANILINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC.
US EPA 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
METHYLMERCURY 022967- 92 -6
010972 TAMASHIRO. H.. M ARAKAKI. H. AKAGI, M FUTATSUKA AND L.H ROHT 1984. CAUSES OF DEATH IN MINAMATA DISEASE: ANALYSIS OF DEATH
CERTIFICATES INT. ARCH OCCUR. ENVIRON HEALTH 54 135-146.
U S. EPA 1995 MERCURY STUDY REPORT TO CONGRESS. OFFICE OF RESEARCH AND DEVELOPMENT. WASHINGTON, DC EXTERNAL REVIEW DRAFT
EPA/600/P-94/002Ab.
U S EPA 1994 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
METOLACHLOR 051218-45-2
010951 US EPA 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METOLACHLOR PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF WATER. WASHINGTON, DC
MIREX 002385-85-5
010952 NTP (NATIONAL TOXICOLOGY PROGRAM) 1990 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF MIREX (CAS NO 2385-85-5) IN
F344/N RATS. (FEED STUDIES) NTP TR 313 US DEPT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH
US EPA 1993 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-39
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
NIAGARA BLUE 4B 002429-74-5
010141 US EPA 1987, HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NIAGARA BLUE 4B PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EHERGENCY RESPONSE.
WASHINGTON, DC.
NICKEL REFINERY DUST
005103 CHOVIL. A, RB SUTHERLAND AND M HALLIDAY 1981 RESPIRATORY CANCER IN A COHORT OF NICKEL SINTER PLANT WORKERS. BR J 1ND MED. 38. 327-333
PETO. J. H CUCKLE, R DOOL. ET AL 1984 RESPIRATORY CANCER MORTALITY OF WELSH NICKEL REFINERY WORKERS IN NICKEL IN THE HUMAN
ENVIRONMENT PROCEEDINGS OF A JOINT SYMPOSIUM, MARCH, 1983 IARC SCIENTIFIC PUBL NO 53. IARC. LYON. FRANCE P 36-46
ENTERLINE. PE AND GM MARSH 1982 MORTALITY AMONG WORKERS IN A NICKEL REFINERY AND ALLOY MANUFACTURING PLANT IN WEST VIRGINIA J NAT
CANCER INST 68 925-933
MAGNUS. K, A ANDERSEN AND A HOGETVEIT 1982 CANCER OF RESPIRATORY ORGANS AMONG WORKERS AT A NICKEL REFINERY IN NORWAY INT J CANCER 30
681-685
US EPA 1985 HEALTH ASSESSMENT DOCUMENT FOR NICKEL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK
NICKEL SUBSULFIDE 012035-72-2
005768 CHOVIL. A. RB SUTHERLAND AND M HALLIDAY 1981. RESPIRATORY CANCER IN A COHORT OF NICKEL SINTER PLANT WORKERS BR J IND MED 38 327-333
PETO, J. H CUCKLE, R DOOL. £T AL 1984 RESPIRATORY CANCER MORTALITY OF WELSH NICKEL REFINERY WORKERS IN: NICKEL IN THE HUMAN
ENVIRONMENT PROCEEDINGS OF A JOINT SYMPOSIUM, MARCH. 1983 IARC SCIENTIFIC PUBL NO 53, IARC, LYON. FRANCE P 36-46
ENTERLINE. PE AND GM MARSH 1982. MORTALITY AMONG WORKERS IN A NICKEL REFINERY AND ALLOY MANUFACTURING PLANT IN WEST VIRGINIA J NAT
CANCER INST 68 925-933
MAGNUS, K. A ANDERSEN AND A HOGETVEIT 1982 CANCER OF RESPIRATORY ORGANS AMONG WORKERS AT A NICKEL REFINERY IN NORWAY, INT J CANCER 30
681-685
US EPA 1985 HEALTH ASSESSMENT DOCUMENT FOR NICKEL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. RESEARCH TRIANGLE PARK, NC.
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-40
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
000098-95-3
010969 CUT. 1993 CHRONIC INHALATION TOXICITY STUDY OF NITROBENZENE IN B6C3F1 NICE. FISHER 344 RATS, AND SPRAGUE-OAWLEY CO RATS. COT. PO BOX
12137, RESEARCH TRIANGLE PARK, NC. 27709.
US EPA. 1994 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE)
NITROFURAZONE 000059-87-0
005110 ERTURK, E, JE MORRIS, SM COHEN, ET AL 1970 TRANSPLANTABLE RAT MAMMARY TUMORS INDUCED BY 5-NITRO-2-FURALDEHYDE SEMICARBAZONE AND BY
FORMIC ACID 2~[4-(5-NITRQ-2-FURYL)-2-THIAZQLYL]HYDRAZIDE. CANCER RES. 30(5): 1409-1412
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITROFURANS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
NITRQPRGPANE, 2- 000079-46-9
010142 LEWIS TR, CE ULRICH AND WM BUSEY 1979 SUBCHRONIC INHALATION TOXICITY OF NITROMETHANE AND 2-NITROPROPANE. J ENVIRON PATHOL TOXICOL
2(5): 233-249
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-NITROPROPANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1988 EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2-NITROPROPANE. PREPARED BY THE CARCINOGEN ASSESSMENT GROUP. OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT. WASHINGTON DC. FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON DC.
NITROSO-DI-N-BUTYLAMINE, N- 000924-16-3
010143 BERTRAM JS AND AW CRAIG 1970 INDUCTION OF BLADDER TUMORS IN MICE WITH DIBUTYLNITROSAMINES BR J CANCER 24: 352-359
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA. 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-41
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
NITRQSO-DI-N-PROPYLAMINE, N- 000621-64-7
010147 DRUCKREY H 1967. QUANTITATIVE ASPECTS IN CHEMICAL CARCINOGENS. IN: POTENTIAL CARCINOGENIC HAZARDS FROM DRUGS. UICC MONOGRAPH. SERIES 7.
SPRINGER-VERLAG, BERLIN P 60-78,
DRUCKREY H, R PURESSMAN. S IVANKGVIC AND 0 SCHMAHL 1967. QRSANOTROPIC CARCINOGENIC EFFECT OF 65 DIFFERENT N-NITROSO COMPOUNDS ON BD
RATS Z KREBSFQRSCH. 69. 103-201.
US EPA, 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION (CRAVE) WORK GROUP.
NITROSO-N-ETHYLUREA, N- 000759-73-9
010426 BULAY, 0, SS MIRV1SH. H GARCIA, AF PELFRENE. B GOLD AND M EAGAN 1979. CARCINOGENICITY TESTS OF SIX NITROSAMIOES AND NITROSOCYANAMIDE
ADMINISTERED ORALLY TO RATS J NATL CANCER INST 62. 1523-1528
US EPA. 1988 EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSO-N-ETHYLUREA IN SUPPORT OF REPQRTA6LE QUANTITY ADJUSTMENTS
PURSUANT TO CERCLA SECTION 102. PREPARED BY THE CARCINOGEN ASSESSMENT GROUP, OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. WASHINGTON,
DC FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON,'DC.
US EPA, 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
NITROSO-N-HETHYLUREA, N- 000684-93-5
010427 REDOY. JK AND MS RAO 1975. PANCREATIC ADENOCARCINOMA IN INBRED GUINEA PIGS INDUCED BY N-METHYL-N-NITRQSQUREA CANCER RES 35 2269-2277
US EPA. 198B. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSO-N-METHYLUREA IN SUPPORT OF REPORTABLE QUANTITY ADJUSTMENTS
PURSUANT TO CERCLA SECTION 102 PREPARED BY THE CARCINOGEN ASSESSMENT GROUP, OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, WASHINGTON.
DC FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
US EPA 1992. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
NITROSODIETHANOLAMINE, N- 001116-54-7
Q10144 LIJINSKY W AND RM KOVATCH 1985 INDUCTION OF LIVER TUMORS IN RATS BY NITROSODIETHANOLAMINE AT LOW OOSES. CARCINOGENESIS. 6. 1679-1681.
US EPA, 1986, HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-42
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
NITROSODIETHYLAMINE, N- 000055-18-5
010145 PETO R. R GRAY. P BRANTOM AND P GRASSO. 1984. NITROSAMINE CARCINOGENESIS IN 5120 RODENTS CHRONIC ADMINISTRATION OF 16 DIFFERENT
CONCENTRATIONS OF NDEA. NDMA. NPYR AND NPIP IN THE WATER OF 4440 INBRED RATS, WITH PARALLEL STUDIES ON NDEA ALONE OF THE EFFECT OF AGE OF
STARTING (3. 6 OR 20 WEEKS) AND OF SPECIES (RATS. MICE OR HAMSTERS). IARC SCI PUBL 57: 627-665.
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
US EPA. 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
NITROSODIMETHYLAMINE, N- 000062-75-9
010146 PETO R. R GRAY, P BRANTOM AND P GRASSO 1984 NITROSAMINE CARCINOGENESIS IN 5120 RODENTS. CHRONIC ADMINISTRATION OF 16 DIFFERENT
CONCENTRATIONS OF NDEA. NDMA. NPYR AND NPIP IN THE WATER OF 4440 INBRED RATS. WITH PARALLEL STUDIES ON NDEA ALONE OF THE EFFECT OF AGE OF
STARTING (3, 6 OR 20 WEEKS) AND OF SPECIES (RATS. MICE OR HAMSTERS). IARC SCI PUBL. 57 627-665
US EPA. 1986 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON. DC.
US EPA 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
NITROSODIPHENYLAMINE. N- 000086-30-6
005112 NCI (NATIONAL CANCER INSTITUTE). 1979 BIOASSAY OF N-NITROSODIPHENYLAMINE (CAS NO 86-30-6) FOR POSSIBLE CARCINOGEN1C1TY NCI
CARCINOGENESIS TECH REP SER NO 164. NIH 79-1720. NTIS PB 298-275.
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR N-NITROSODIPHENYLAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA. 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-43
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
NITROSOMETHYLETHYLAMINE, N- 010595-95-6
010148 DRUCKREY H. 1967 QUANTITATIVE ASPECTS IN CHEMICAL CARCINOGENS IN: POTENTIAL CARCINOGENIC HAZARDS FROM DRUGS. UICC MONOGRAPH, SERIES 7
SPRINGER-VERLAG. BERLIN. P 60-78.
DRUCKREY H. R PURESSMAN, S IVANKOVIC AND 0 SCHMAHL 1967. ORGANOTROPIC CARCINOGENIC EFFECT OF 65 DIFFERENT N-NITROSO COMPOUNDS ON BD
RATS. I KREBSFQRSCH. 69' 103-201.
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
R3-44
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NITROSOMETHYLVINYLAMINE, N 004549-40-0
010149 ORUCKREY H. 1967. QUANTITATIVE ASPECTS IN CHEMICAL CARCINOGENS IN- POTENTIAL CARCINOGENIC HAZARDS FROM DRUGS UICC MONOGRAPH, SERIES 7.
SPRINGER-VERLAG, BERLIN P 60-78
DRUCKREY H. R PURESSMAN, S IVANKOVIC AND D SCHMAHL. 1967. ORGANOTROPIC CARCINOGENIC EFFECT OF 65 DIFFERENT N-NITROSO COMPOUNDS ON BD
RATS Z KREBSFORSCH. 69: 103-201
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROSAMINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
US EPA 1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSOMETHYLVINYLAMINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, CARCINOGEN ASSESSMENT GROUP. WASHINGTON DC
NITROSOPYRROLIDINE. N- 000930-55-2
010300 PREUSSMAN R, 0 SCHMAHL AND G EISENBRAND. 1977. CARCINOGENICITY OF N-NITROSOPYRROLIDINE- DOSE-RESPONSE STUDY IN RATS I KREBSFORSCH. 90-
161-166.
US EPA. 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
PARATHION 000056-38-2
005116 US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR PARATHION PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA, 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
PENTABROMO-6-CHLOROCYCLOHEXANE. 1,2,3.4,5- 000087-84-3
010150 BLAIR EH 1981. TSCA SEC 8(E) SUBMISSION 8E HQ-0381-0393, 88-8100295 BY DOW CHEMICAL CO. OFFICE OF TOXIC SUBSTANCES. US EPA. WASHINGTON,
DC.
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1.2,3.4,5-PENTABROMO-6-CHLOROCYCLOHEXANE PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC
R3-45
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN1CITY July 1997
PENTACHLORONITROBENZENE -68-8
010151 INNES, JRM, BM ULLAND. MG VALERIA, ET AL, 1969 BIOASSAY OF PESTICIDES AND INDUSTRIAL CHEMICALS FOR TUMORIGENICITY IN MICE- A PRELIMINARY
NOTE. J NATL CANCER INST. 41. 1101-1114,
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PENTACHLORONITROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON. DC.
PENTACHLOROPHENOL 000087-86-5
010381 NTP (NATIONAL TOXICOLOGY PROGRAM). 1989 TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF PENTACHLOROPHENOL (CAS NO
87-86-5) IN B6C3F1 MICE (FEED STUDIES) NTP TECH REPORT NO 349 NIH PUBL NO 89-2804.
US EPA 1990 CARCINOGEN RISK ASSESSMENT VERIFICATION (CRAVE) WORK GROUP.
PHENYLENEDIAHINE, 0- 000095-54-5
010152 WEISBURGER EK. AB RUSSFIELD AND F HOMBURGER, ET AL 1978 TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR
LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL 2(2)- 325-356.
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 0-PHENYLENEDIAMINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
PHENYLPHENOL, 2- 000090-43-7
010153 HIRAGA K AND U FUJI I 1981 INDUCTION OF TUMOURS OF THE URINARY SYSTEM IN F344 RATS BY DIETARY ADMINISTRATION OF SODIUM 0-PHENYLPHENATE.
FOOD COSMET TOXICOL 19(3) 303-310
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-PHENYLPHENOL PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
POLYBROMINATED BIPHENYLS
010154 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983 CARCINOGENESIS STUDIES OF POLYBROMINATED BIPHENYL MIXTURE IN F344/N RATS AND B6C3F1 MICE (GAVAGE
STUDIES) FIREMASTER FF-1 CASE NO 67774-32-7. NTP. RESEARCH TRIANGLE PARK. NC
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR POLYBROMINATED BIPHENYLS (PBBS) PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC
R3 46
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
POLYCHLORINATED BIPHENYLS 001336-36-3
005118 NORBACK, OH, AND RH WELTMAN 1985. POLYCHLORINATED BIPHENYL INDUCTION OF HEPATOCELLULAR CARCINOMA IN THE SPRAGUE-DAWLEY RAT. ENVIRON
HEALTH PERSPECT. 60- 97-105.
US EPA. 1990 DRINKING WATER CRITERIA DOCUMENT FOR POLYCHLORINATED BIPHENYLS CPCBS) PREPARED BY THE OFFICE Of HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON. DC.
US EPA. 1990 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
PROPYLENE OXIDE 000075-56-9
010156 OlMKELBERG H. 1982, CARCINOGENICITY OF ETHYLENE OXIDE AND 1.2-PROPYLENE OXIDE UPON INTRAGASTRIC ADMINISTRATION TO RATS BR J CANCER. 46.
924-933
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPYLENE OXIDE BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA. 1990 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
010155 NTP (NATIONAL TOXICOLOGY PROGRAM) 1985, TOXICOLOGY AND CARCINOGENESIS STUDIES OF PROPYLENE OXIDE (CAS NO 75-56-9) IN F344/N RATS AND
B6C3F1 MICE (INHALATION STUDIES) NTP TECH REP SER NO 267 NTP. RESEARCH TRIANGLE PARK, NC. NIH PUB NO 85-2527.
RENNE RA, WE GIODENS. GA BOOKMAN, R KOVATCH. JE HASEMAN AND WJ CLARKE. 1986 NASAL CAVITY NEOPLASIA IN F344/N RATS AND (C57BL/6XC3H)F1
MICE INHALING PROPYLENE OXIDE FOR UP TO TWO YEARS J NATL CANCER INST 77: 573-582.
US EPA 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
QUINOLINE 000091-22-5
010158 HIRAO K. Y SHINOHARA. H TSUDA. ET AL 1976. CARCINOGENIC ACTIVITY OF QUINOLINE ON RAT LIVER. CANCER RES 36 329-335
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR QUINOLINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC
R3-47
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY
July 1997
RDX / (CYCLONITE) 000121-82-4
010157 LISH PM. BS LEVINE. EM FUREDI, EM SAGARTZ AND VS RAC 1984. DETERMINATION OF THE CHRONIC MAMMALIAN TOXICOLOGICAL EFFECT OF RDX TWENTY
FOUR MONTH CHRONIC TQXICITY/CARCINOGENICITY STUDY OF HEXAHYDRA-1.2.5-TRINITRO-1.3.5-TRIAZINE (RDX) IN THE B6C3F1 HYBRID MOUSE. PHASE VI.
VOL 1 ITT RESEARCH INSTITUTE, CHICAGO, IL. US ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND. CONTRACT NO DAMD 17-79-C-9161 NTIS
AD-A181766,
US EPA 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR RDX (CYCLONITE). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC,
US EPA, 1988 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP,
SELENIUM SULFIDE 007446-34-6
010194 NCI/NTP (NATIONAL CANCER INSTITUTE/NATIONAL TOXICOLOGY PROGRAM) 1980
CARCINOGENICITY, NCI TECHNICAL REPORT SERIES NO, 194. NTP NO. 80-17.
BIOASSAY OF SELENIUM SULFIDE (GAVAGE) FOR POSSIBLE
US EPA, 1989. HEALTH AND ENVIRONMENTAL EFFECTS FOR SELENIUM AND COMPOUNDS, PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
US EPA 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP,
SIMAZINE 000122-34-9
010195 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SIMAZINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
US EPA 1989, CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
005126 BRL (B10NETICS RESEARCH LABORATORIES) 1968. EVALUATION OF CARCINOGENIC TERATOGENIt AND MUTAGENIC ACTIVITIES OF SELECTED PESTICIDES ON
INDUSTRIAL CHEMICALS. VOL I. CARCINOGENIC STUDY PREPARED FOR NATIONAL CANCER INSTITUTE. US DEPT COMMERCE. NAT TECH INFO SERV,
WASHINGTON, DC NTIS PB223159
US EPA 1988 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SODIUM DIETHYLDITHIOCARBAMATE BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE," CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON. DC
STYRENE 000100-42-5
010480 CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER. (513) 569-7300,
R3-48
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
TCOO, 2,3.7,8- 001746-01-6
005128 KOCIBA. RJ. OG KEYES. JE BOWER ET AL. 1978 RESULTS OF A TWO-YEAR CHRONIC TOXICITY AND ONCOGENICITY STUDY OF
2.3.7.8-TETRACHLOROOIBENZO-P-OIOXIN IN RATS. TOXICOL APPL PHARMACOL 46(2): 279-303.
US EPA. 1985 HEALTH ASSESSMENT DOCUMENT FOR POLYCHLORINATED DIBENZO-P-DIOXIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH. EPA 600/8-84-014F NTIS PB86-122546
US EPA. 1984 HEALTH EFFECTS ASSESSMENT FOR 2.3.7.8-TCOD. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON, DC.
US EPA 1989 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
TETRACHLOROETHANE, 1,1,1.2- 000630-20-6
010302 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983 CARCINOGENESIS STUDIES OF 1.1.1.2-TETRACHLOROETHANE (CAS NO 630-20-6) IN F344/N RATS AND B6C3F1
MICE (GAVAGE STUDIES) NTP-81-53. N1H PUBL NO 83-1793. NTP TECHNICAL REPORT SERIES NO 237 NTIS. SPRINGFIELD. VA.
US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR 1.1.1.2-TETRACHLOROETHANE PREPARED BY THE
OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER.
WASHINGTON, DC.
TETRACHLOROETHANE, 1,1,2,2- 000079-34-5
005130 NCI (NATIONAL CANCER INSTITUTE) 1978 BIOASSAY OF 1.1.2.2-TETRACHLOROETHANE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP
SER NO 27. OHEW NO (NIH) 78-827
US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED ETHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
DC.
US EPA 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
TETRACHLOROETHYLENE 000127-18-4
010482 CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER (513) 569-7300
R3-49
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
TETRACHLOROTOLUENE, PARA, ALPHA, ALPHA, ALPHA- 005216-25-1
005028 FUKADA, KS. MATSASHITA AND K TAKEMOTO 1979. CARCINOGENICITY OF P-CHLOR06ENZOTRICHLORIDE. PROC OF JAPAN ASSOC OF I NO HEALTH, P 330-331
US EPA 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED CHLORINATED TOLUENES PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON. DC,
TETRACHLOROVINPHOS / (STIROFOS) 000961-11-5
010159 NCI (NATIONAL CANCER INSTITUTE) 1978 BIOASSAY OF TETRACHLOROVINPHOS FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH REP SER NO 33.
NTIS PB278650.
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROFOS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON. DC.
TOLUENE-2.4-DIAHINE 000095-80-7
010160 NCI (NATIONAL CANCER INSTITUTE) 1979 BIOASSAY OF 2,4-DIAMINQTQLUENE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH REP SER NO. 162
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2.4-TOLUENEDIAMINE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC
TOLUIDINE, P- 000106-49-0
010162 WEISBURGER EK. AB RUSSFIELD AND F HOMBURGER. ET AL 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR
LONG-TERM TOXICITY OR CARCINOGENICITY J ENVIRON PATHOL TOXICOL 2(2). 325-356.
US EPA. 1984 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIDINES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC
TOXAPHENE 008001-35-2
005134 LITTON BIONETICS. INC 1978. CARCINOGENIC EVALUATION IN MICE: TOXAPHENE. PREPARED BY LITTON BIONETICS. INC . KENSINGTON, MD FOR HERCULES.
INC, WILMINGTON. OE, LBI PROJECT NO. 20602.
US EPA. 1987 HEALTH EFFECTS ASSESSMENT FOR TOXAPHENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR TOXAPHENE- PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS, WASHINGTON, DC.
US EPA 1987 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP,
R3-50
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
TRICHLOROANILINE HYDROCHLORIDE. 2,4,6- 033663-50-2
005142 WEISBURGER. EL. AB RUSSFIELD. R HOMBURGER. ET AL 1978 TESTING OF 21 ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG-TERM TOXKITY
OR CARCINOGENICITY J ENVIRON PATHOL TOXICOL. 2. 325-356
US EPA 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
TRICHLOROANILINE. 2,4,6- 000634-93-5
010487 WEISBURGER. EL. AB RUSSFIELD. F HOMBURGER. ET AL. 1978. TESTING OF 21 ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR LONG TERM TOXICITY
OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL 2. 325-356
US EPA. 1987 HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
TRICHLOROETHANE, 1.1,2- 000079-00-5
005144 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1.1.2-TRICHLOROETHANE FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO
74. DHEW NO NIH 78-1324.
US EPA. 1980 AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED ETHANES PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
DC.
US EPA. 1984 HEALTH EFFECTS ASSESSMENT FOR 1.1,2-TRICHLOROETHANE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE. WASHINGTON. DC
US EPA 1986 CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
TRICHLOROETHYLENE 000079-01-6
010483 CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300
R3-51
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
TRICHLOROPHENOL, 2,4.6- 000088-06-2
010428 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF 2,4.6-TRICHLOROPHENOL FOR POSSIBLE CARCINOGENICITY NCI CARCINOGENESIS TECH REP SER NO
155. DHEW NO NIH 79-1711.
US EPA. 1980 AMBIENT QUALITY CRITERIA DOCUMENT FOR CHLORINATED PHENOLS. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS. WASHINGTON.
DC.
US EPA. 1984 HEALTH EFFECTS ASSESSMENT FOR 2.4,6-TRICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EHERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA 1987 HEALTH AW ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC
US EPA. 1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK 6ROUP.
TRICHLOROPROPANE, 1,2,3- 000096-18-4
010849 NTP (NATIONAL TOXICOLOGY PROGRAM) 1991. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1.2,3-TRICHLOROPROPANE (CAS
NO 96-18-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). BOARD DRAFT NTP TR 384 NIH PUB NO 91-2839. US DEPT OF HEALTH AND HUMAN
SERVICES, PUBLIC HEALTH SERVICE, NIH, RESEARCH TRIANGLE PARK, NC.
US EPA, 1993. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR CCRAVE) WORK
TRIFLURALIN 001582-09-8
010163 EMMERSON JL. EC PIERCE, JP MCGRATH, ET AL 1980 THE CHRONIC TOXICITY OF COMPOUND 36352 (TRIFLURALIN) GIVEN AS A COMPOUND OF THE DIET TO
FISCHER 344 RATS FOR TWO YEARS. STUDIES R-87 AND R-97 (UNPUBLISHED STUDY RECEIVED SEPTEMBER 18. 1980 UNDER 1471-35. SUBMITTED BY ELANCO
PRODUCTS CO , DIVISION OF ELI LILLY AND CO., INDIANAPOLIS. IN).
US EPA 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA, 1987. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-52
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
TRIMETHYL PHOSPHATE 000512-56-1
010164 NCI (NATIONAL CANCER INSTITUTE) 1978. BIQASSAY OF TR1METHYLPHOSPHATE FOR POSSIBLE CARCINOGENZCITY NCI CARCINOGEN TECH REP SER NO 81.
US EPA. 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIMETHYL PHOSPHATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON, DC.
TRINITROTOLUENE. 2,4,6- 000118-96-7
010476 US DOO (DEPARTMENT OF DEFENSE) 1984 AD-A168637. DEFENSE TECHNICAL CENTER. STATION, ALEXANDRIA. VA.
US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2,4,6-TRINITRQTQLUENE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
WASHINGTON. DC.
US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP
R3-53
-------
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY July 1997
VINYL CHLORIDE 000075-01-4
010368 FERON. VJ, CFM HENDRIKSEN, AJ SPEEK, ET AL 1981 LIFESPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS. FOOD COSMET TOXICOL 19(3)
317-333
US EPA 1984. HEALTH EFFECTS ASSESSMENT FOR VINYL CHLORIDE. BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL
CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC
US EPA. 1985. DRINKING WATER CRITERIA DOCUMENT FOR VINYL CHLORIDE PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI OH FOR THE OFFICE OF DRINKING WATER. WASHINGTON, DC
US EPA, 1990. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
010367 MALTONI, C. G LEFEMINE, A CILIBERTI ET AL 1980 VINYL CHLORIDE CARCINOGENICITY BIOASSAYS (BT PROJECT) AS AN EXPERIMENTAL MODEL FOR RISK
IDENTIFICATION AND ASSESSMENT IN ENVIRONMENTAL AND OCCUPATIONAL CARCINOGENESIS EPIDEMIOL ANIM EPIDEMIOL HUM' CAS CHLORURE VINYLE
MONOMERE, (REUN CLUB CANCEROG CHIM). 20TH, MEETING DATE 1979, P 11-112. PUBL ESSENT, PARIS, FRANCE.
MALTONI, C, G LEFEMINE, A CILIBERTI ET AL. 1981. CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE A OF RISK ASSESSMENT ON AN
EXPERIMENTAL BASIS. ENVIRON HEALTH PERSPECT, 41: 329
US EPA 1985 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROETHENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AW EMERGENCY RESPONSE, WASHINGTON, DC
US EPA 1990. RISK ASSESSMENT VERIFICATION (CRAVE) WORK GROUP.
US EPA, 1994. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP,
R3-54
-------
Table 4
Radionuclide Carcinogencity,-- Slope Factors
(In Units of Picocuries)
JULY 1997
NOTE: To convert radionuclide slope factors into the International System (SI)
activity units of becquerels (Bq), multiply each value in Table 4 by 27.03.
-------
Table 4: Radionuclide Carcinogenicity -- Slope Factors2
(In Units of Picocuriesb)
JULY 1997
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Actinium (89)
Americium (95)
Antimony (51)
Argon (18)
Isotope6
Ac-225
Ac-227
Ac-227+D
Ac-228
Am-241
Am-242
Am-242m
Am-243
Am-243+D
Sb-122
Sb-124
Sb-125
Sb-125+D
Sb-126
Sb-126m
Sb-127
Sb-129
Ar-41
CASRNd
014265-85-1
014952-40-0
014952-40-Q(+D)
014331-83-0
014596-10-2
013981-54-9
013981-54-9(m)
014993-75-0
014993-7§-Q(+D)
014374-79-9
014683-10-4
014234-35-6
014234-35-6(+D)
015756-32-8
015756-32-8(m)
013968-50-S
014331-88-5
014163-25-8
Radioactive
Half-rite6
1 OOE+01
2.18E+01
2.18E+01
6.13E+00
4.32E+02
1.60E+01
1 .52E+02
7.38E+03
7.38E+03
2 70E+00
6.02E+01
2.77E+00
2.77E+00
1.24E+01
1.90E+01
3.85E+00
4 40E+00
1.83E+00
D
Y
Y
H
Y
H
Y
Y
Y
D
D
Y
Y
D
M
D
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
W
W
W
*
61
Absorption
Factor (f,)B
1.00E-03
1.00E-03
1.00E-03
1 OOE-03
t.OOE-03
1 .OOE-03
1 .OOE-03
1. OOE-03
1 .OOE-03
1 OOE-01
1.00E-01
1 .OOE-01
1. OOE-01
1. OOE-01
1. OOE-01
1. OOE-01
1 OOE-01
Ingestion
(Risk/pCi)
1.42E-10
3.52E-10
6.26E-10
1 62E-12
3.28E-10
1.47E-12
2.92E-10
3.27E-10
3.31E-10
8.81E-12
1.07E-11
2.97E-12
3.54E-12
9.73E-12
7.28E-14
8.48E-12
1.86E-12
Inhalation
(Risk/pCi)
4.16E-09
7.08E-08
7.87E-08
3.27E-1 1
3.85E-08
1.04E-11
3 49E-08
3.82E-08
3.82E-08
5.46E-12
1 .32E-1 1
5.20E-12
5.85E-12
8.41 E-1 2
6.43E-14
6.05E-12
8.60E-13
4.71E-16
External Exposure
(Risk/yr per pCi/g soil)
7.81 E-09
2.35E-11
5.97E-07
3.28E-06
4 59E-09
5 76E-09
8.76E-1 1
2.43E-08
2.66E-07
1.61E-06
7.35E-06
1.34E-06
1.34E-06
1 .03E-05
5.78E-06
2.40E-06
5 56E-06
JTable 4 continues on the following page: Refer to Endnotes on the last page ]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JULY 1997
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Astatine (85)
Barium (56)
Beryllium (4)
Bismuth (83)
Bromine (35)
Cadmium (20)
Isotope0
At-217
Ba-131
Ba-133
Ba-133m
Ba-137m
Ba-139
Ba-140
Be-7
8i-206
Bi-207
Bi-210
Bi-211
Bi-212
Bi-213
Bi-214
Br-82
Cd-109
Cd-115
CASRN"
017239-90-6
014914-75-1
013981-41-4
013981-41-4(m)
013981-97-0(m)
014378-25-7
014798-08-4
013966-02-4
015776-19-9
013982-38-2
014331-79-4
015229-37-5
014913-49-6
015776-20-2
014733-03-0
014686-69-2
014109-32-1
014336-68-6
Radioactive
Half-life6
3.23E-02
1.18E+01
1.05E+01
3.89E+01
2.55E+00
8.31E+01
1.28E+01
5.34E+01
6.24E+00
3.34E+01
5.01 E+00
2.13E+00
6 06E+01
4.57E+01
1.99E+01
3.53E+01
4 64E+02
5.35E+01
S
D
Y
H
M
M
D
D
D
Y
D
M
M
M
M
H
D
H
ICRP
Lung
Class'
D
D
D
D
D
D
D
Y
W
W
W
W
W
W
W
D
Y
Y
Gl
Absorption
Factor (f,)9
9.50E-01
1 .OOE-01
1.00E-01
1. OOE-01
1. OOE-01
1. OOE-01
1 .OOE-01
5.00E-03
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5 OOE-02
5.00E-02
5.00E-02
9.50E-01
5.00E-02
5 OOE-02
Ingestion
(Risk/pCi)
8.99E-18
1.70E-12
2.70E-12
2.76E-12
2.43E-15
3.04E-13
1.18E-11
8.64E-14
711E-12
5.05E-12
7.29E-12
1.82E-14
6.20E-13
4.40E-13
1.95E-13
1.42E-12
8.01E-12
7.29E-12
Inhalation
(RisWpCi)
5.14E-16
4.79E-13
4.03E-12
5.60E-13
1.57E-15
1.53E-13
3.17E-12
1.78E-13
5.07E-12
9.42E-12
512E-11
1.74E-12
3.65E-11
3.09E-11
1 46E-1 1
7.86E-13
1.85E-11
4.93E-12
External Exposure
(Risk/yr per pCi/g soil)
8.71E-10
1.27E-06
9.15E-07
1.00E-07
2.21 E-06
8.35E-08
6.00E-07
1.73E-07
1 .20E-05
5.49E-06
O.OOE+0
1.48E-07
6.67E-07
4 62E-07
6 02E-06
1 01 E-05
5.62E-10
7.02E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity Slope Factors'
(In Units of Picocuriesb)
JULY 1997
Element
(Atomic Number)
Calcium (20)
Carbon (6)
Cerium (58)
Cesium (55)
Isotope"
Cd-115m
Ca-45
Ca-47
C-11
C-14
C-15
Ce-141
Ce-143
Ce-144
Ce-144+D
Cs-131
Cs-134
Cs-134m
Cs-135
Cs-136
Cs-137
Cs-137+D
Cs-138
CASRN"
014336-68-6(m)
013966-05-7
001439-99-2
014333-33-6
014762-75-5
015929-23-4
013967-74-3
0141 19-19-8
014762-78-8
014762-78-8(+D)
014914-76-2
013967-70-9
013967-70-9(m)
015726-30-4
014234-29-8
010045-97-3
010045-97-3(+D)
015758-29-9
Radioactive
Half-life"
4 46E+G1
1 .63E+02
4.54E+00
2.05E+01
5.73E+03
2.45E+00
3.25E+01
3.3QE+01
2.84E+02
2.84E+02
9.69E+00
2.Q6E+QO
2.9QE+00
2.30E+06
1.32E+01
3.02E+01
3.02E+01
3.22E+01
D
D
D
M
Y
S
D
H
D
D
D
Y
H
Y
D
Y
Y
M
ICRP
Lung
Class*
Y
W
W
D
it
D
Y
Y
Y
Y
D
D
D
D
D
D
D
D
Gl
Absorption
Factor (f,)9
5.00E-02
3.00E-01
3.00E-01
9.50E-Q1
1.00E+00
9.50E-01
3.00E-04
3-OOE-04
3.00E-04
3.00E-04
9.50E-01
i,50E-01
9.50E-01
9.50E-01
9 50E-01
9.50E-01
9.50E-01
9.50E-01
Lifetime Excess
Ingestion
(Risk/pCi)
1.42E-11
2.02E-12
6.66E-12
4.49E-14
1.03E-12
6.62E-16
3.91E-12
5-91E-12
2.96E-11
2.97E-11
1.80E-13
4.73E-11
4.54E-14
4.53E-12
7 74E-12
3.16E-11
3.16E-11
1.76E-13
Slope Factor
Total Cancer Risk Per Unit Intake or Exposure
Inhalation
(Risk/pCi)
1.70E-11
2.51E-12
5.22E-12
3.38E-14
6.99E-15
8.06E-16
4.32E-12
3.84E-12
1.08E-10
1.08E-10
1 06E-13
2.89E-11
3.10E-14
2.71E-12
4.65E-12
1.91E-11
1.91E-11
1 30E-13
External Exposure
(Risk/yr per pCi/g soil)
8.55E-08
3.88E-18
4.12E-06
3.61 E-06
O.OOE+0
...
1.41E-07
7.32E-07
2 58E-08
1.56E-07
2.34E-09
5.88E-06
1 .96E-08
O.OOE+0
8.13E-06
O.OOE+0
2.09E-06
9.45E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JULY 1997
Slope Factor
Lifetime Excess Total Cancer Risk Per
Element
(Atomic Number)
Chlorine (17)
Chromium (24)
Cobalt (27)
Copper (29)
Curium (96)
Dysprosium (66)
Isotope0
CI-36
CI-38
Cr-51
Co-57
Co-58
Co-58m
Co-60
Cu-64
Cm-242
Cm-243
Cm-243+D
Cm-244
Cm-245
Cm-246
Cm-247
Cm-248
Dy-165
Dy-166
CASRN"
013981-43-6
014158-34-0
014392-02-0
013981-50-5
01381-38-9
01381-38-9(m)
010198-40-0
013981-25^
015510-73-3
015757-87-6
015757-87-6(+D)
013981-15-2
015621-76-8
015757-90-1
015758-32-4
015758-33-5
013967-64-1
015840-01-4
Radioactive
Half-life"
3.01 E+05
3.72E+01
2.77E+01
2.71 E+02
7.08E+01
9.15E+00
5.27E+00
1.27E+01
1 .63E+02
2.85E+01
2.85E+01
1.81E+01
8.50E+03
4.75E+03
1.56E+07
3.39E+05
2.33E+00
8.16E+01
Y
M
D
D
D
H
Y
H
D
Y
Y
Y
Y
Y
Y
Y
H
H
ICRP
Lung
Class'
D
D
Y
Y
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)9
9.50E-01
9.50E-01
1 .OOE-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
5.00E-01
1 .OOE-03
1.00E-03
1 .OOE-03
1. OOE-03
1 .OOE-03
1 .OOE-03
1. OOE-03
1 OOE-03
3.00E-04
3.00E-04
Ingestion
(Risk/pCi)
2.23E-12
2.07E-13
1.38E-13
9.71E-13
2.82E-12
9.46E-14
1.89E-11
5.25E-13
3.83E-11
2.51E-10
2.52E-10
2.11E-10
3.35E-10
3.32E-10
309E-10
1 31E-09
3.26E-13
9.42E-12
Inhalation
(Risk/pCi)
1.30E-12
1.63E-13
1.74E-13
2.88E-12
5.17E-12
8.90E-14
6.88E-1 1
4.18E-13
3.16E-09
2.89E-08
2.90E-08
2.43E-08
3.92E-08
3.90E-08
3.58E-08
1.46E-07
2.24E-13
7.82E-12
Unit Intake or Exposure
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
647E-06
1.02E-07
2.07E-07
3.73E-06
3.21 E-11
9.76E-06
6.72E-07
2.34E-11
1.71E-07
1.72E-07
2.07E-11
5.51 E-08
1.81 E-11
1 .03E-06
1 .47E-1 1
6.18E-08
2 72E-08
[Table 4 continues on the following page' Refer to Endnotes on the last page.]
-------
Table 4; Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuries5)
JULY 1997
Element
(Atomic Number)
Erbium (63)
Europium (63)
Fluorine (9)
Francium (87)
Gadolinium (64)
Gallium (31)
Germanium (32)
Gold (79)
Holmium (67)
Hydrogen (1)
Isotope0
Er-169
Er-171
Eu-152
Eu-154
Eu-155
Eu-156
F-18
Fr-221
Fr-223
Gd-153
Gd-159
Ga-67
Ga-72
Ge-71
Au-196
Au-198
Ho-166
H-3
CASRNd
015840-13-8
014391-45-8
014683-23-9
015585-10-1
014391-16-3
014280-35-4
013981-56-1
015756-41 -§
015756-98-6
014276-65-4
014041-42-0
014119-09-6
013982-22-4
014374-81-3
014914-16-0
010043-49-0
013967-65-2
010028-17-8
Radioactive
Half-life"
i.40E+00
7.52E+00
1.36E+01
8.80E+QO
4.96E+00
1 52E+01
1.10E+02
4.8QE+00
2.18E+00
2.42E+02
1.86E+01
3.26E+00
1.41E+01
1.18E-1-01
6.18E+00
2.70E+00
2.68E+Q1
1.23E+01
D
H
Y
Y
Y
D
M
M
M
D
H
D
H
D
D
D
H
Y
ICRP
Lung
Class'
W
W
W
W
W
W
D
D
D
W
W
W
W
W
Y
Y
W
V
61
Absorption
Factor (f,)9
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1.00E-03
1.00E-03
9.50E-01
9.50E-01
9.50E-01
3.00E-04
3.00E-04
1.00E-03
1.00E-03
9.50E-01
1.00E-01
1.00E-01
3.00E-04
1.00E+00
Lifetime Excess
Ingestion
(Risk/pCi)
2.12E-12
1.63E-12
5.73E-12
9.37E-12
1.65E-12
1.09E-11
1.09E-13
1.45E-13
4.46E-13
1.32E-12
2 60E-12
8.36E-13
4.77E-12
1 18E-14
1.30E-12
5.28E-12
7.57E-12
7.15E-14
Slope Factor
Total Cancer Risk Per
Inhalation
(Risk/pCi)
1.51E-12
7.50E-13
7.91E-11
9.15E-11
9.60E-12
9.26E-12
6.54E-14
8.02E-12
5.90E-13
3.20E-12
1.24E-12
5.14E-13
2.17E-12
5.84E-14
1.04E-12
3.64E-12
4.06E-12
9.59E-14
Unit Intake or Exposure
External Exposure
(Risk/yr per pCi/g soil)
6.52E-12
1.04E-06
4.08E-06
4.65E-06
6.08E-08
5.40E-06
3.50E-06
6.74E-08
4.17E-08
7.22E-08
9.59E-08
3.61 E-07
1.12E-05
1.56E-11
1.41E-06
1.37E-06
6 96E-08
O.OOE+0
P"able 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity Slope Factors2
(In Units of Picocuriesb)
JULY 1997
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Indium (49) ln-113m
ln-114
ln-114m
ln-115
ln-115m
Iodine (53) 1-122
1-123
1-125
1-126
1-129
1-130
1-131
1-132
1-133
1-134
1-135
1ridium(77) lr-190
lr-194
CASRNd
014885-78-0(m)
013981-55-0
013981-55-0(m)
014191-71-0
014191-71-0(m)
018287-75-7
015715-08-9
014158-31-7
014158-32-8
015046-84-1
014914-02-4
010043-66-0
014683-16-0
014834-67-4
014914-27-3
014834-68-5
014981-91-0
014158-35-1
Radioactive
Half-life"
1.66E+00
7.19E+01
4.95E+01
4.60e-H5
4.36E+00
3.62E+00
1.31E+01
6.01 E+01
1.29E+01
1.57E+07
1.24E+01
8.04E+00
2.30E+00
2.08E+01
5.26E+01
6.61 E+00
1.18E+01
1.92E+01
H
S
D
Y
H
M
H
D
D
Y
H
D
H
H
M
H
D
H
ICRP
Lung
Class'
W
W
W
W
W
D
D
D
D
D
D
D
D
D
D
D
Y
Y
Gl
Absorption
Factor (f,)9
2.00E-02
2.00E-02
2.00E-02
2.00E-02
2.00E-02
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
1 .OOE-02
1 .OOE-02
Ingestion
(Risk/pCi)
8.30E-14
4.53E-15
2.06E-1 1
3.49E-1 1
3.42E-13
2.16E-14
5.42E-13
2.58E-11
4.82E-11
1.84E-10
4.85E-12
3.62E-11
6.62E-13
1.06E-11
231E-13
2.27E-12
495E-12
7.00E-12
Inhalation
(Risk/pCi)
5.77E-14
5.81E-15
2.53E-11
2.07E-10
1.75E-13
2.24E-14
2.94E-13
1.71E-11
3.15E-11
1.22E-10
2.61E-12
2.33E-1 1
3 52E-13
6.02E-12
1 38E-13
1.18E-12
4.49E-12
4.18E-12
External Exposure
(Risk/yr per pCi/g soil)
7.82E-07
1.13E-07
2.00E-07
O.OOE+0
4.29E-07
3.41 E-06
2.52E-07
2.39E-09
1 .49E-06
2.69E-09
7.93E-06
1.25E-06
8.75E-06
2.20E-06
1.02E-05
6.23E-06
4.65E-06
3.17E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuriesb)
JULY 1997
Element
(Atomic Number)
Iron (26)
Krypton (36)
Lanthanum (57)
Lead (82)
Lutetium (71)
Isotope"
Fe-55
Fe-59
Kr-83m
Kr-85
Kr-85m
Kr-87
Kr-88
Kr-89
Kr-90
La- 140
Pb-203
Pb-20i
Pb-210
Pb-21 0+D
Pb-21 1
Pb-212
Pb-21 4
Lu-177
CASRNd
014681-59-5
014596-12-4
013965-98-5(m)
013983-27-2
013983-27-2(m)
014809-68-8
014995-61-0
016316-03-3
015741-13-6
013981-28-7
014687-25-3
014119-30-3
014255-04-0
014255-04-0(+D)
015816-77-0
015092-94-1
015067-28-4
014265-75-9
Radioactive
Half-life*
2 70E+00
4.46E+01
1.83E+00
1.07E+01
4.48E+00
7.63E+01
2.84E+00
3.16E+00
3.23E+01
4.02E+01
5.2QE+01
3 25E+00
2.23E+Q1
2.23E+01
3.61 E+01
1.06E+Q1
2.68E+01
6.71 E+00
Y
D
H
Y
H
M
H
M
S
H
H
H
Y
Y
M
H
M
D
ICRP
Lung
Class'
W
W
*
*
*
*
*
*
*
W
D
D
D
D
D
D
D
Y
61
Absorption
Factor (f,)9
1.00E-01
1.00E-G1
...
...
1 .OOE-03
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
2.00E-01
3.00E-04
Lifetime Excess
Ingestion
(Risk/pCi)
3.51E-13
5.87E-12
...
_~
9.46E-12
1.03E-12
2.09E-13
6.75E-10
1.01E-09
3.38E-13
1.80E-11
2.94E-13
2.95E-12
Slope Factor
Total Cancer Risk Per Unit Intake or Exposure
Inhalation
(Risk/pCi)
560E-13
7.08E-12
3.48E-17
2.87E-16
2.75E-16
1.20E-15
2.20E-15
1.61E-15
1.60E-15
510E-12
3.10E-13
6.85E-14
1.67E-09
3.86E-09
1.03E-11
3.85E-11
6.23E-12
220E-12
External Exposure
(Risk/yr per pCi/g soil]
O.OOE+0
4.63E-06
_.
_
--
__
9.11E-06
6 40E-07
O.OOE+0
1.12E-10
1.45E-10
1.85E-07
3.00E-07
7.09E-07
7.22E-08
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity Slope Factors'
(In Units of Pieoeuriesb)
JULY 1997
Element
(Atomic Number)
Manganese (25)
Mercury (80)
Molybdenum (42)
Neodymium (60)
Neptuniym (93)
Nickel (28)
Isotope6
Mn-52
Mn-54
Mn-56
Hg-197
Hg-203
Mo-99
Nd-147
Nd-149
Np-236
Np-237
Np-237+D
Np-238
Np-239
Np-24Q
Np-240m
Ni-59
Ni-63
Ni-65
CASRNd
014092-99-0
013966-31-9
014681-52-8
013981-51-6
013982-78-0
014119-15-4
014269-74-0
015749-81-2
015700-36-4
013994-20-2
013994-20-2{+D)
015766-25-3
013968-59-7
015690-84-3
015690-84-3(m)
014336-70-0
013981-37-8
014833-49-9
Radioactive
Half-life"
5.59E-1-00
3.13E+02
2.58E+00
6.41 E+01
4.66E+01
6.60E+01
1.10E+01
1 .73E+00
1.15E+05
2.14E+06
2.14E+06
2.12E+00
2.36E+00
6.50E+01
7.40E+00
7.50E+Q4
1.0QE+02
2.52E+00
D
D
H
H
D
H
D
H
Y
Y
Y
D
D
M
M
Y
Y
H
ICRP
Lung
Class'
W
W
W
W
W
Y
Y
Y
W
w
W
W
W
W
W
W
W
W
Gi
Absorption
Factor (f,)9
1 OOE-01
1.00E-01
1. OOE-01
2.00E-02
2.00E-02
8.00E-01
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1 .OOE-03
1.00E-03
1. OOE-03
1. OOE-03
1. OOE-03
5.00E-02
5.00E-02
5.00E-02
Lifetime Excess
Ingestion
(Risk/pCi)
6.01E-12
1.96E-12
8.57E-13
1.18E-12
2.64E-12
227E-12
5.88E-12
4.55E-13
9,31 E-13
295E-10
3.00E-10
4.56E-12
4.27E-12
1.77E-13
2.42E-14
1.85E-13
5.50E-13
5.62E-13
Slope Factor
Total Cancer Risk Per Unit Intake or Exposure
Inhalation
(Risk/pCi)
4.40E-12
3.69E-12
5.21E-13
6.95E-13
3.03E-12
4.48E-12
4.84E-12
4.22E-13
3.87E-12
3.45E-08
3.45E-08
4.68E-12
2.41 E-1 2
1.31 E-13
2.83E-14
4.01 E-1 3
1.01E-12
3.59E-13
External Exposure
(Risk/yr per pCi/g soil)
1.34E-05
3.26E-06
6.95E-06
5.47E-08
6.27E-07
5.46E-07
3.22E-07
1 .08E-06
9.22E-08
7.56E-09
4.62E-07
1.95E-06
2.42E-07
3.65E-06
1.05E-06
O.OOE+O
O.OOE+0
2.14E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors2
(In Units of Picocuriesb)
JULY 1997
Element
(Atomic Number)
Niobium (41)
Osmium <76)
Palladium <46)
Phosphorus {1 5)
Platinum (78)
lsotopec
Nb-93m
Nb-94
Nb-95
Nb-95m
Nb-97
Nb-97m
Os-185
Os-191
Os-191m
Os-193
Pd-100
Pd-101
Pd-103
Pd-107
Pd-109
P-32
P-33
Pt-191
CASRN"
007440-03-1 (m)
014681-63-1
013967-76-5
013967-76-5(m)
018496-04-3
018496-04-3
-------
Table 4: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuriesb)
JULY 1997
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Pt-193
Pt-193m
Pt-197
Pt-197m
Plutonium (94) Pu-236
Pu-238
Pu-239
Pu-240
Pu-241
Pu-241+D
Pu-242
Pu-243
Pu-244
Pu-244+D
Polonium (84) Po-210
Po-212
Po-213
Po-214
CASRN"
015735-70-3
015735-70-3(m)
015735-74-7
015735-74-7(m)
015411-92-4
013981-16-3
015117-48-3
014119-33-6
014119-32-5
014119-32-5(+D)
013982-10-0
015706-37-3
014119-34-7
014119-34-7(+D)
013981-52-7
015389-34-1
015756-57-7
015735-67-8
Radioactive
Half-life6
5.00E+01
4.33E+00
1.83E+01
9.44E+01
2 85E+00
8 78E+01
2.41 E+04
6.57E+03
1.44E+01
1 .44E+01
3.76E+05
4.96E+00
8.26E+07
8.26E+07
1.38E+02
2.98E-07
4.20E-06
1 .64E-04
Y
D
H
M
Y
Y
Y
Y
Y
Y
Y
H
Y
Y
D
S
S
S
ICRP
Lung
Class'
D
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
W
Gl
Absorption
Factor (f,)9
1.00E-02
1 .OOE-02
1 OOE-02
1. OOE-02
1.00E-03
1.00E-03
1.00E-03
1.00E-03
1 .OOE-03
1.00E-03
1. OOE-03
1 OOE-03
1 OOE-03
1 OOE-03
1.00E-01
1.00E-01
1 .OOE-01
1.00E-01
Ingestion
(Risk/pCi)
1.62E-13
2.51E-12
2.12E-12
3.25E-13
7.68E-1 1
2.95E-10
3.16E-10
3.15E-10
5.20E-12
3.33E-10
3.00E-10
369E-13
3 13E-10
3.19E-10
3.26E-10
4.51 E-23
6.70E-22
2.12E-20
Inhalation
(Risk/pCi)
7.89E-14
5.76E-13
4.54E-13
1.00E-13
1.34E-08
2.74E-08
2.78E-08
2.78E-08
2.81 E-10
3.88E-08
2.64E-08
2.67E-13
2.67E-08
2.67E-08
2.14E-09
5.93E-21
7.80E-20
2.77E-18
External Exposure
(Risk/yr per pCi/g soil)
O.OOE-K)
7.44E-09
3.15E-08
1 .65E-07
232E-11
1.94E-11
1.26E-11
1.87E-11
O.OOE+0
4.59E-09
1.55E-11
1 .89E-08
1.29E-11
3.65E-06
3 30E-1 1
0 OOE+0
1.18E-10
323E-10
[Table 4 continues on the following page. Refer to Endnotes on the last page.]
11
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JULY 1997
Element
(Atomic Number)
Potassium (19)
Praseodymium (59)
Promethium (61)
Protactinium (91)
Radium (88)
Isotope6
Po-215
Po-216
Po-218
K-40
K-42
Pr-142
Pr-143
Pr-144
Pr-144m
Pm-147
Pm-148
Pm-148m
Pm-149
Pa-231
Pa-233
Pa-234
Pa-234m
Ra-223
CASRN"
015706-52-2
015756-58-8
015422-24-9
013966-00-2
014378-21-3
014191-64-1
014981-79-4
014119-05-2
0141 19-Q5-2(m)
014380-75-7
014683-19-3
01 4683-1 9-3(m)
015765-31-8
014331-85-2
013981-14-1
015100-28-4
015100-28-4(m)
015623-45-7
Radioactive
Half-life*
1 78E-03
1.46E-01
3 05E+00
1.28E+09
1.24E+01
1.91E+01
1 .36E+01
1-73E+01
7.2QE+00
2.62E+00
5,37E+00
4.13E+01
5,31 E+01
3.73E+04
2.70E+01
6.70E+00
1.17E+00
1.14E+01
S
S
M
Y
H
H
D
M
M
Y
D
D
H
Y
D
H
M
D
ICRP
Lung
Class*
W
W
W
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
Gl
Absorption
Factor (f,)8
1.00E-01
1.00E-01
1.00E-01
9 50E-01
9.50E-01
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
3.00E-04
1.00E-03
1.00E-03
1.QOE-03
1 .OOE-03
2.00E-01
Lifetime Excess
Ingestion
(RisWpCi)
4.99E-19
8.79E-17
5.08E-14
1 .25E-1 1
1.29E-12
6.98E-12
6.60E-12
8.08E-14
323E-14
1.41E-12
1.44E-11
9.93E-12
5.52E-12
1.49E-10
4.69E-12
2.13E-12
4.77E-15
2.34E-10
Slope Factor
Total Cancer Risk Per
Inhalation
(RisWpCi)
4.48E-17
2 95E-15
3.69E-12
7.46E-12
7.56E-13
4.16E-12
5.60E-12
1.31E-13
5.61 E-14
7.49E-12
1.05E-11
2 95E-1 1
3.57E-12
2 42E-08
4.92E-12
1.30E-12
6.27E-15
3.60E-09
Unit Intake or Exposure
External Exposure
(Risk/yr per pCi/g soil)
5.11E-10
5.62E-1 1
0 OOE-i-0
6.11E-07
1.09E-06
2.34E-07
3.41E-14
1.33E-07
1.85E-09
6.35E-12
221E-06
7.32E-06
3.65E-08
2.71 E-08
4.54E-07
6.60E-06
4.05E-08
2.44E-07
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
12
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors*
(In Units of Picocuriesb)
JULY 1997
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Radon (86)
Rhodium (45)
Ra-224
Ra-225
Ra-226
Ra-226+O
Ra-228
Ra-228+D
Rn-2t9
Rn-220
Rn-222+D
Rh-103m
Rh-1Q5
Rh-105m
Rh-106
CASRNd
013233-32^1
013981-53-8
013982-63-3
013982-83-3(+D)
015262-20-1
01 5262-20-1 (+D)
014835-02-0
022481-48-7
1 014859-67-7(+D)
007440-1 6-6(m)
014913-89-4
014913-89-4(m)
014234-34-5
Radioactive
Half-life8
3.62E+00
1.48E+01
1.60E+03
1.60E+03
5.75E+00
5.75E+00
3.96E+00
5.56E+01
3.82E+00
5.61 E+01
3.54E+01
4.50E+01
2.99E+01
1 To derive the inhalation slope factor for Rn-222+D, EPA's
exposure
assumptions, including an inhalation rate of 2.2E+04
level month (WLM). A more detailed description
222 and its Short Half-Life
Decay Products,
D
D
Y
Y
Y
Y
S
s
D
M
H
S
S
Office
L/day;
ICRP
Lung
Class'
W
w
W
w
w
w
-
*
*
Y
Y
Y
Y
of Radiation
Gl
Absorption
Factor (f,)9
2.00E-01
2
2
2
.OOE-01
.OOE-01
.OOE-01
2.00E-01
2
5.
5
5
.OOE-01
-_
_
.OOE-02
.OOE-02
.OOE-02
Ingestion
(Risk/pCi)
1 49E-10
1 57E-10
2.95E-10
2 96E-10
2.46E-10
2.48E-10
8.19E-15
1.93E-12
1.08E-15
5.00E-02 3.63E-15
and Indoor Air (OR1A) uses
50% equilibrium for decay
of ORIA's radon risk assessment
methodology
products; and
is provided in
Inhalation External Exposure
(Risk/pCi) (Risk/yr per pCi/g soil)
2.25E-09
2.38E-09
2.72E-09
2.75E-09
9.61 E-10
9.94E-10
6.91E-14
1.92E-13
7.57E-12
1.28E-14
1.22E-12
925E-16
2.
1.
1.
6.
48E-OB
71E-09
31E-08
74E-06
O.OOE+0
3.
1,
1.
5.
2.
2.
28E-06
72E-07
88E-09
85E-11
49E-07
27E-08
4.62E-15 7.57E-07
a slightly different risk model and set of
a risk coefficient of 2.36E-4
the EPA CRAVE Summary
cases
per working
Sheet, Inhaled Rn-
[Table 4 continues on the following page' Refer to Endnotes on the last page.]
13
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JULY 1997
Element
(Atomic Number)
Rubidium (37)
Ruthenium (44)
Samarium (62)
Scandium (21)
Selenium (34)
Silicon (14)
Isotope0
Rb-82
Rb-86
Rb-87
Rb-88
Rb-89
Ru-97
Ru-103
Ru-105
Ru-106
Ru-106-i-D
Sm-147
Sm-151
Sm-153
Sc-46
Sc-47
Sc-48
Se-75
Si-31
CASRN"
014391-63-0
014932-53-7
013982-13-3
014928-36-0
014191-65-2
015758-35-7
013968-53-1
014331-95^1
013967-48-1
01 3967-48-1 (+D)
014392-33-7
015715-94-3
015766-00-4
013967-63-0
014391-96-9
014391 -B6-7
014265-71-5
014276-49-4
Radioactive
Half-life8
1 .25E+00
1.87E+01
4.73e+10
1.78E+01
1.54E+01
2.90E+00
3.94E+01
4.44E+00
3.68E+02
3.68E+02
1.06e+1 1
9.0QE+01
4.67E+01
8.38E+01
3.42E+00
4.37E+01
1.20E+02
1.57E+02
M
D
Y
M
M
D
D
H
D
D
Y
Y
H
D
D
H
D
M
ICRP
Lung
Class*
D
D
D
D
D
Y
Y
Y
Y
Y
W
W
W
Y
Y
Y
W
W
31
Absorption
Factor (f,)9
9.50E-01
9.50E-01
9.50E-01
9.50E-01
9.50E-01
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
3.00E-04
3.00E-04
3.00E-04
1.00E-04
1.00E-04
1.00E-04
8.00E-01
1 .OOE-02
Lifetime Excess
Ingestion
(Risk/pCi)
1.05E-14
7.12E-12
3.68E-12
1.46E-13
8.65E-14
5.88E-13
3.32E-12
1-15E-12
3.45E-11
3.45E-11
2.51E-11
4.60E-13
4.02E-12
5.73E-12
2.95E-12
6.65E-12
6.53E-12
5.04E-13
Slope Factor
Total Cancer Risk Per Unit Intake or Exposure
Inhalation
(Risfc/pCi)
1.17E-14
4.21 E-1 2
2.26E-12
1.36E-13
6.92E-14
4.09E-13
4.59E-12
8.02E-13
1.15E-10
1.15E-10
6.93E-09
4.63E-12
2.18E-12
1.31E-11
2.01 E-12
4.20E-12
4.92E-12
3.29E-13
External Exposure
(Risk/yr per pCi/g soil)
3.89E-06
3.71 6-07
O.OOE+0
2.68E-06
8.47E-06
4.52E-07
1.70E-06
2.88E-06
o.ooe+o
7.57E-07
O.OOE+0
2.92E-13
4.65E-08
7.89E-06
2.50E-07
1.31E-05
8.89E-07
3.45E-09
[Table 4 continues on the following page: Refer to Endnotes on the last page.)
14
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors3
(In Units of Picocuries")
JULY 1997
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Silver (47)
Sodium (11)
Strontium (38)
lsotopec
Ag-105
Ag-108
Ag-108m
Ag-108m+D
Ag-109m
Ag-110
Ag-110m
Ag-111
Na-22
Na-24
Sr-82
Sr-85
Sr-85m
Sr-89
Sr-90
Sr-90+D
Sr-91
Sr-92
CASRNd
014928-14-4
014391-65-2
014391-65-2m
014391-65-2m(+D)
014378-38-2(m)
014391-76-5
014391 -76-5(m)
157690-04-0
013966-32-0
013982-04-2
014809-50-8
013967-73-2
013967-73-2(m)
014158-27-1
010098-97-2
010098-97-2(+D)
014331-91-0
014928-29-1
Radioactive
Half-life9
4.13E+01
2.37E+00
1.27E+02
1.27E+02
3.96E+01
2.46E+01
2.50E+02
7.46E+00
2.60E+00
1.50E+01
2.50E+01
6.48E+01
6.77E+01
5.06E+01
2.86E+01
2.86E+01
9.50E+00
2.71 E+00
D
M
Y
Y
S
S
D
D
Y
H
D
D
M
D
Y
Y
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
D
D
D
D
D
D
D
D
D
D
Gl
Absorption
Factor (f,)9
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
9.50E-01
9.50E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
3.00E-01
Ingestion
(Risk/pCi)
1.63E-12
6.94E-15
6.05E-12
6.05E-12
2.71E-16
2.44E-15
8.43E-12
6.83E-12
8.02E-12
1.38E-12
2.58E-1 1
1.40E-12
1.80E-14
1.03E-11
4.09E-1 1
5.59E-11
2.82E-12
2.03E-12
Inhalation
(Risk/pCi)
2.33E-12
9.43E-15
7.02E-1 1
7.02E-11
3.46E-16
3.16E-15
3.21 E-11
5.24E-12
4.88E-12
7.51E-13
8.87E-12
1.14E-12
7.13E-15
3.68E-12
5.94E-11
6.93E-1 1
7.79E-13
4.70E-13
External Exposure
(Risk/yr per pCi/g soil)
5.78E-08
5.61 E-06
5.62E-06
1.16E-09
1.13E-07
1.05E-05
8.51 E-08
8.18E-06
1.77E-05
9.00E-11
1.54E-06
5.24E-07
5.38E-10
O.OOE+0
O.OOE+0
2.67E-06
5.20E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
15
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JULY 1997
Element
(Atomic Number)
Sulfur (16)
Tantalum (73)
Technetium (43)
Tellurium (52)
Isotope*
S-35
Ta-182
Tc-95
Tc-95nn
Tc-i6
Tc-96m
Tc-97
Tc-97m
Tc-99
Tc-99m
Te-125m
Te-127
Te-127m
Te-129
Te-129m
Te-131
Te-131m
Te-132
CASRN"
015117-53-0
013982-00-8
014809-56-4
014809-56-4(m)
01480&44-7
014808-«4-7(m)
015759-35-0
015759-35-0(m)
014133-76-7
014133-76-7(m)
014390-73-9(m)
013981^9-2
013981-49-2(m)
014269-71-7
014269-71 -7(m)
014683-12-6
014683-12-6(m)
014234-28-7
Radioactive
Half-life8
8 74E+01
1.15E+02
2.00E-H31
610E+01
4.28E+00
5.15E+Q1
2.60E+06
8.90E+01
213E+05
6.02E+00
5.8QE+01
9.3SE+00
1 09E+02
6 96E+01
3.36E+01
2.50E+01
3.00E+01
7.82E+01
0
D
H
D
D
M
Y
D
Y
H
D
H
D
M
D
M
H
H
ICRP
Lung
Class'
0
Y
W
W
W
W
W
W
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)8
8.00E-01
1.00E-03
8.00E-01
8.00E-01
8-OOE-01
8.00E-01
8.00E-01
8.00E-01
8.00E-01
8.00E-01
2 OOE-01
2 OOE-01
2.00E-01
2.00E-01
2. OOE-01
2.00E-01
2.00E-01
2-OOE-01
Lifetime Excess
Ingestion
(RisWpCi)
4.16E-13
7.03E-12
6.81 E-1 4
1.24E-12
2.28E-12
2.61E-14
1.58E-13
1.20E-12
1.40E-12
5.58E-14
251E-12
8.55E-13
6-01E-12
1.48E-13
1 17E-11
390E-13
8.81E-12
1.22E-11
Slope Factor
Total Cancer Risk Per
Inhalation
(Risk/pO)
1.85E-13
1.65E-11
3.38E-14
2.10E-12
1.94E-12
2.26E-14
3.44E-13
1.96E-12
2.89E-12
3.49E-14
2.85E-12
4.32E-13
1.31 E-1 1
1.46E-13
1.33E-11
2.48E-13
840E-12
838E-12
Unit Intake or Exposure
External Exposure
(Risk/yr per pCi/g soil)
O.OOE+0
4.66E-06
2.72E-06
2.08E-06
9.36E-06
7 72E-08
2.49E-10
2.67E-10
6.19E-13
2.51 E-07
2.16E-09
1.62E-08
7.10E-10
1 46E-07
6 92E-08
1.35E-06
5.31E-06
4 31 E-07
[Table 4 continues on the following page; Refer to Endnotes on the last page.]
16
-------
Table 4: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuries")
JULY 1997
Element
(Atomic Number)
Terbium (65)
Thallium (81)
Thorium (90)
Thulium (69)
Tin (50)
Isotope6
Tb-158
Tb-160
TI-202
TI-204
TI-208
TI-209
Th-227
Th-228
Th-228+D
Th-229
Th-229+D
Th-230
Th-231
Th-232
Th-234
Tm-170
Tm-171
Sn-113
CASRN"
015759-55-4
013981-29-8
015720-57-7
013968-51-9
014913-50-9
015690-73-0
015623-47-9
014274-82-9
014274-82-9(+D)
015594-54-4
015594-54-4(+D)
014269-63-7
014932-40-2
007440-29-1
015065-10-8
013981-30-1
014333-45-0
013966-06-8
Radioactive
Half-life"
1.50E+02
7.23E+01
1.22E+01
3.78E+00
3.05E+00
2.20E+00
1.87E+01
1.91E+00
1.91E+00
7.34E+03
7.34E+03
7.70E+04
2.55E+01
1 41E-HO
241E+01
1.29E+02
1 .92E+00
1 15E+02
Y
D
D
Y
M
M
D
Y
Y
Y
Y
Y
H
Y
D
D
Y
D
ICRP
Lung
Class'
W
W
D
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)9
3.00E-04
3.00E-04
9 50E-01
9.50E-01
9.50E-01
9.50E-01
2 OOE-04
2 OOE-04
2.00E-04
2.00E-04
2.00E-04
2.00E-04
2 OOE-04
2.00E-04
2.00E-04
3.00E-04
3.00E-04
2.00E-02
Lifetime Excess
Ingestion
(Risk/pCi)
4.20E-12
7.62E-12
1.01E-12
1.97E-12
1.75E-14
1.40E-14
4.04E-11
6 29E-1 1
231E-10
5.65E-11
3.56E-10
3.75E-1 1
1.79E-12
3.28E-11
1.93E-11
7.50E-12
5.86E-13
3.72E-12
Slope Factor
Total Cancer Risk Per
Inhalation
(Risk/pCi)
7.04E-11
1.14E-11
6.07E-13
1.15E-12
1.36E-14
1.12E-14
4.31E-09
9.45E-08
9.68E-08
7.60E-08
8.26E-08
1.72E-08
1.10E-12
1 .93E-08
1.90E-11
1.10E-11
1.84E-12
6.61E-12
Unit Intake or Exposure
External Exposure
(Risk/yr per pCi/g soil)
_
4.03E-06
1 .42E-06
872E-10
1.45E-05
7.83E-06
1.74E-07
5.28E-10
9.94E-07
5.94E-08
5.99E-07
4 40E-1 1
2.09E-09
1.97E-11
3.50E-09
3 84E-09
3 15E-10
2.96E-09
[Table 4 continues on the following page Refer to Endnotes on the last page.]
17
-------
Table 4: Radionuclide Carcinogenicity Slope Factors2
(In Units of Picocuriesb)
JULY 1997
Element
(Atomic Number)
Tungsten (74)
Uranium (92)
Vanadium (23)
Isotope'
Sn-121
Sn-121m
Sn-125
Sn-126
W-181
W-185
W-187
U-232
U-233
U-234
U-235
U-235+D
U-236
U-237
U-238
U-238+D
U-240
V-48
CASRN11
014683-06-8
014683-06-8(m)
014683-08-0
015832-50-5
015749-46-9
014932-41-3
014983-48-3
014158-29-3
013968-55-3
013966-29-5
015117-96-1
015117-96-1(+D)
013982-70-2
014269-75-1
007440-61-1
007440-61 -1(+D)
015687-53-3
014331-97-6
Radioactive
Half-life*
2.71 E+01
5.55E+01
9.64E+00
1 .OOE+05
1.21E+02
7.51E+01
2.38E+01
7.20E+01
1.59E+05
2.45E+05
7.04E-1-08
7 04E-1-08
2 34E+07
6.75E+00
4.47E+09
4.47E+Q9
1.41E+01
1 .60E+01
H
Y
D
Y
D
D
H
Y
Y
Y
Y
Y
Y
D
Y
Y
H
D
ICRP
Lung
Classf
W
W
W
W
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
61
Absorption
Factor (f,)a
2.00E-02
2.00E-02
2 OOE-02
2.00E-02
3.00E-01
3 OOE-01
3.00E-01
5 OOE-02
5.00E-02
5.00E-02
5.00E-02
5.00E-02
5-OOE-02
5. OOE-02
5, OOE-02
5.00E-02
5 OOE-02
1. OOE-02
Lifetime Excess
Ingest ion
(Risk/pCi)
1.22E-12
2.00E-12
1 .68E-1 1
2.12E-11
2.72E-13
2.04E-12
2.46E-12
8.12E-11
4.48E-11
4.44E-11
452E-11
4.70E-1 1
4.21E-11
398E-12
4-27E-11
6.20E-1 1
5.47E-12
7.56E-12
Slope Factor
Total Cancer Risk Per
Inhalation
(Risk/pCi)
6.13E-13
7.46E-12
1 19E-11
4.26E-1 1
8.02E-14
4.26E-13
5.29E-13
5.29E-08
1.41E-08
1 .40E-08
1 30E-08
1.30E-08
1 .32E-08
3.12E-12
1-24E-08
1.24E-08
335E-12
6.84E-12
Unit Intake or Exposure
External Exposure
(Risk/yr per pCi/g soil)
1.21E-06
3.32E-08
2.11E-08
5 03E-1 1
1 63E-06
3.42E-11
3.52E-11
2.14E-11
2.63E-07
2 65E-07
1.72E-11
1.37E-07
1.50E-11
5.25E-08
1.09E-10
1 12E-05
[Tabte 4 continues on the following page: Refer to Endnotes on the last page.]
18
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors2
(In Units of Picocuriesb)
JULY 1997
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Xenon (54) Xe-122
Xe-123
Xe-125
Xe-127
Xe-129m
Xe-131m
Xe-133
Xe-133m
Xe-135
Xe-135m
Xe-137
Xe-138
Yttrium (39) Y-90
Y-91
Y-91m
Y-92
Y-93
Zinc (30) 2n-65
CASRN"
015151-09^
015700-10-4
013994-18-8
013994-19-9
013965-99-6(m)
01 4683-1 1-5(m)
014932-42-4
014932-42-4(m)
014995-62-1
01 4995-62-1 (m)
014835-21-3
015751-81-2
010098-91-6
014234-24-3
014234-24-3(m)
015751-59-4
014981-70-5
013982-39-3
ICRP Gl
Radioactive Lung Absorption Ingestion
Half-life8 Class* Factor (f,)9 (Risk/pCi)
2.01E+01
2.14E+00
1.68E-I-01
3.64E+01
8.89E+00
1.18E+01
5.25E+00
2.19E+00
9.11E+00
1.54E+01
3.83E+00
1.41E+01
6.41E+01
5 85E+01
4.97E+01
3.54E+00
1.01E+01
2.44E+02
H
H
H
D
rj *
D
D
D
H *
M
M
M
H Y 1. OOE-04 1.50E-11
D Y 1. OOE-04 1.35E-11
M Y 1 OOE-04 3.69E-14
H Y 1. OOE-04 1.95E-12
H Y 1. OOE-04 5.74E-12
D Y 5.00E-01 9.93E-12
Inhalation
(Risk/pCi)
3.08E-15
8 92E-16
1 20E-15
4.09E-16
574E-16
4.13E-16
4.14E-16
5.12E-16
7.45E-16
1.88E-16
1.39E-15
2.06E-15
9.90E-12
1.85E-11
2.99E-14
1.61E-12
3.48E-12
9.98E-12
External Exposure
(Risk/yr per pCi/g soil)
_
...
...
...
._
...
...
...
...
...
0 OOE+0
1 41E-08
1 90E-06
9.80E-07
3.41 E-07
2.27E-06
[Table 4 continues on the following page: Refer to Endnotes on the last page.]
19
-------
Table 4: Radionuclide Carcinogenicity Slope Factors1
(In Units of Picocuriesb)
JULY 1937
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
isotope' CASRN"
Radioactive
Half-life6
ICRP
Lung
Class'
Gl
Absorption
Factor (I,)8
Ingestion
(Risk/pCi)
Inhalation
(Risk/pCi)
External Exposure
(Risk/yr per pCi/g soil)
Zirconium (40)
Zn-6i
Zn-69m
Zr-93
Zr-95
Zf-97
013982-23-5
013982-23-5(m)
015751-77-6
013967-71-0
014928-30-4
5 56E+01 M
1.38E+01 H
1.53E+Q6 Y
6.40E+01 D
1.696+01 H
Y
Y
W
W
W
5.00E-01
5.00E-01
2.00E-03
2.00E-03
2.00E-03
6 19E-14
1.52E-12
5216-13
3.92E-12
1.046-11
1.04E-13
1.17E-12
5.26E-12
6.48E-12
4.73E-12
2.03E-11
1.43E-06
O.OOE+0
2.81 E-06
6.85E-07
ITable 4 continues on the following page: Refer to Endnotes on the last page,]
20
-------
Table 4: Radionuclide Carcinogenicity - Slope Factors3 JULY 1997
(In Units of Picocuriesb)
ENDNOTES:
EPA classifies all radionuclides as Group A (known human) carcinogens. Radionuclide slope factors are calculated by EPA's Office of Radiation and Indoor Air (ORIA)
to assist HEAST users with risk-related evaluations and decision-making at various stages of the remediation process. Ingestton and inhalation slope factors are central
estimates in a linear model of the age-averaged, lifetime attributable radiation cancer incidence (fatal and nonfatal cancer) risk per unit of activity inhaled or ingested, expressed
as risk/picocurie (pCi). External exposure slope factors are central estimates of the lifetime attributable radiation cancer incidence risk for each year of exposure to external
radiation from photon-emitting radionuclides distributed uniformly in a thick layer of soil, and are expressed as risk/yr per pCi/gram of soil. If required, slope factors in Table
4 can be converted into the International System (SI) units of becquerels (1 Bq = 1 nuclear transformation per second) by dividing each inhalation, ingestion, or external
exposure value by 27.03. Users can calculate cancer risks using slope factors expressed in either customary units or SI units with equivalent results, provided that they also
use air, water and soil concentration values in the same system of units. For a discussion on the derivation of radionuclide slope factors and guidance on their use, refer to
the User's Guide section on radionuclide carcinogenicity.
A curie (Ci), the customary unit of activity, is equal to 3.7 x 1010 nuclear transformations per second. 1 picocurie (pCi) = 10 n Cl
For each radionuclide listed, slope factors correspond to the risks per unit intake or exposure for that radionuciide only, except when marked with a "-t-D" to indicate that
the risks from associated short-lived radioactive decay products (i.e., those decay products with radioactive half-lives less than or equal to 6 months) are also included. Refer
to Exhibit 1 in the User's Guide section on radionuclide carcinogenicity for guidance on determining slope factors for partial or complete radioactive decay chains.
Chemical Abstract Service Reference Number (CASRN). For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each
chain member.
e Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year, For those radionuclides with decay products (+D), half-lives are listed for the parent radionuclide.
Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gastrointestinal (Gl) absorption factors are the fractional amounts of each radionuclide absorbed across the Gl tract into the bloodstream. Lung clearance classificatioi
and Gl absorption factors are provided for reference only. Do not use these factors to adjust inhalation or ingestion slope factors. See the User's Guide for instructions.
21
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APPENDIX A: TECHNICAL INFORMATION
I. DATA SOURCES AND SELECTION CRITERIA USED IN HEAST
II. DOSE CONVERSIONS ON HEAST
III. CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY
NUMBER CROSS REFERENCE
IV. EFFECT LEVEL DEFINITIONS
V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
-------
APPENDIX A-l
I. DATA SOURCES AND SELECTION CRITERIA USED IN HEAST
A. Description of Sources and Documents Cited in HEAST
1. The Integrated Risk Information System (IRIS)
IRIS is an on-line data base developed by the EPA for compilation of risk
assessment and regulatory information on chemicals and physical agents. IRIS is the
primary communications mechanism for distribution of health hazard assessment
information derived by the various intra-Agency Work Groups. The primary intent of
IRIS is to provide guidance to EPA personnel in making risk management decisions.
An IRIS chemical file contains a Work Group verified summary of the available
information on hazard and dose-response assessment for noncarcinogenic and/or
carcinogenic effects for that chemical and is not an extensive toxicologic data base.
Risk assessment values placed on IRIS are considered Agency consensus and take
precedence over differing risk assessment values from other EPA sources. Each file
includes referenced citations and EPA contacts for obtaining further information on any
specific chemical or agent. The IRIS data base was made available to State and local
governments, as well as to the public, in April 1988.
* Questions concerning IRIS: Call RISK INFORMATION HOTLINE at (513) 569-7254
2. EPA Work Groups and the IRIS Pilot:
Risk assessment values for chemicals currently being considered by EPA, but not
yet on IRIS, are included in HEAST. In the past the EPA Reference Dose/Reference
Concentration (RfD/RfC) and the Carcinogen Risk Assessment Verification Endeavor
(CRAVE) Work Groups used to validate Agency systemic toxicity and carcinogen risk
assessments, respectively. These Work Groups are now replaced by the IRIS Pilot
which will be responsible for resolving any conflicts regarding toxicity values developed
by various Program Offices. The IRIS Pilot peer review panels represent different EPA
offices and external scientists experienced in issues related to both the qualitative and
quantitative risk assessment of carcinogenic and toxic agents. Values verified by this
system must undergo extensive peer review and represent an Agency consensus.
Verified risk assessment values or changes are entered into the IRIS data base
monthly.
* Questions concerning the IRIS Pilot: Call Amy Mills, NCEA Washington at
(202) 260-0569.
A-1
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3. Office of Research and Development (ORD/National Center for
Environmental Assessment (NCEA) OSWER-OAQPS (Office of Solid Waste and
Emergency Response-Office of Air Quality Planning and Standards) Documents:
A listing of most ORD/NCEA OSWER-OAQPS documents can be found in the
Chemical Assessments and Related Activities (CARA) list (available through NTIS) or in
the CERI (Center for Environmental Research Information) Office of Research and
Development publications list. The CARA is produced by the National Center for
Environmental Assessment (NCEA). All OSWER-OAQPS documents are subject to a
minimum of internal EPA peer review or a maximum of EPA/Peer Review
Workshop/Science Advisory Board and public comments prior to finalization.
* Information on the availability of OSWER-OAQPS documents can be obtained from
the following sources:
All Documents:
Technical Information Staff
National Center for Environmental Assessment (RD-689)
U.S. Environmental Protection Agency
401 M Street, S.W.
Washington, D.C. 20460
(202) 260-7345
Published Documents:
Technology Transfer and Support Division, National Risk Management
Research Laboratoryf
Office of Research and Development
U.S. Environmental Protection Agency
26 W. Martin Luther King Drive
Cincinnati, OH 45268
(513)569-7562
tFormerly, Center for Environmental Research Information (CERI)
Documents Available Through RCRA/Superfund:
Hotline Number 1-800-424-9346
A-2
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Documents Available from NTIS:
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
(703) 487-4650
Health Effects Assessments (HEAs): This document series was prepared by the
National Center for Environmental Assessment (NCEA-CIN) for the Office of
Emergency and Remedial Response (Superfund). HEAs are intended for use by the
OERR in evaluating risk for its preliminary assessment process at uncontrolled sites,
and for appraising clean-up alternatives in its remedial investigation/feasibility studies.
HEAs are brief, quantitatively oriented, preliminary assessment of relevant health
effects data. HEAs are subject to internal EPA review by staff within the Office of Health
and Environmental Assessment. Final drafts of HEAs become part of the RCRA and
Superfund dockets and are available through NTIS, This series has recently been
incorporated into the following HEED series.
Health and Environmentai Effects Documents (HEEDs): This document series is
prepared by the National Center for Environmental Assessment (NCEA-CIN) for the
Office of Solid Waste and Emergency Response (OSWER). HEEDs are intended to
support listings under the Resource Conservation and Recovery Act (RCRA) as well as
to provide health-related limits and goals for emergency and remedial actions under the
Comprehensive Environmental Response, Compensation and Liability Act (CERCLA).
Within a HEED, both published literature and information within Agency Program
Offices are evaluated as they pertain to potential human health, aquatic life and
environmental effects of hazardous waste constituents. Quantitative estimates,
including reference doses for chronic and subchronic duration for both inhalation and
oral exposures, carcinogenic potency factors, unit risk estimates for air and drinking
water, and reportable quantities (RQs) based on chronic toxicity and carcinogenicity are
determined when sufficient data are available. HEEDs are subject to internal EPA
review by staff within the Office of Health and Environmental Assessment and the
Office of Pesticides and Toxic Substances. Final drafts of HEEDs become part of the
RCRA and Superfund public dockets and are available through NTIS.
Health and Environmental Effects Profiles (HEEPs): This document series was
prepared by the National Center for Environmental Assessment (NCEA-CIN) for the
Office of Solid Waste and Emergency Response (OSWER). HEEPs have been
superseded by HEEDs since mid-FY87. HEEPs are intended to support listings of
hazardous constituents of a wide range of waste streams under Section 3001 of the
Resource Conservation and Recovery Act (RCRA), as well as to provide health-related
limits for emergency actions under Section 010 of the Comprehensive Environmental
Response, Compensation and Liability Act (CERCLA). HEEPs are summaries of the
A-3
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literature concerning health hazards associated with environmental exposures to
chemicals or compounds and are very similar to HEEDs as described above. HEEPs
were subject to internal EPA review by staff within the Office of Health and
Environmental Assessment. HEEPS are part of the RCRA and CERCLA public
dockets. Final drafts are available through NTIS.
Air Quality Criteria Documents (AQCDs): This document series is prepared by the
National Center for Environmental Assessment (NCEA-RTP) for the Office of Air and
Radiation (OAR). AQCDs are intended to support National Ambient Air Quality
Standards (NAAQS) set under Sections 108-110 of the Clean Air Act. These
documents are evaluations of the available scientific literature on the potential health
effects of air pollutants. AQCDs are subject to internal EPA review by staff within the
Office of Health and Environmental Assessment and the Office of Air and Radiation.
Further review is conducted by the Science Advisory Board/Clean Air Scientific
Advisory Committee, and then, these documents are subject to peer review workshops
and public comments. The AQCDs are mandated by the Clean Air Act and are revised
at 5-year intervals. AQCDs become part of the OAR public docket and final drafts are
available through NTIS.
Health Assessment Documents (HADs): This document series is prepared by the
National Center for Environmental Assessment (NCEA-RTP and NCEA-CIN) for the
Office of Air and Radiation (OAR). HADs are intended for use by the Office of Air
Quality Planning and Standards (OAQPS) to determine possible listing of hazardous air
pollutants (HAP) under sections 111 and 112 of the Clean Air Act. These documents
are evaluations of the available scientific literature on the potential health effects of air
pollutants and serve as the scientific data base for establishing relationships between
exposure concentrations and potential health risks. HADs are subject to internal EPA
review by staff within the Office of Health and Environmental Assessment and the
Office of Air and Radiation. Further review is conducted by the Science Advisory
Board/Clean Air Scientific Advisory Committee, and then, these documents are subject
to peer review workshops and public comments. HADs become part of the OAR public
docket and final drafts are available through NTIS.
4. Miscellaneous Documents:
Drinking Water Criteria Documents (DWCDs): The National Center for Environmental
Assessment (NCEA-CIN) prepares a portion of this document series for the Office of
Water (OW). DWCDs are intended to assist the OW in deriving criteria standards for
chemicals in drinking water, as required under Section 412(b)(3)(A) of the Safe Drinking
Water Act, as amended in 1986. The DWCDs are comprehensive evaluations of
potential health effects, including mechanisms of toxicity, with specific emphasis on
data providing dose-response information. DWCDs contain Health Advisories (Has) for
1-day, 10-day and longer-term exposures and drinking water equivalent levels for
A-4
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lifetime exposures. DWCDs are subject to internal EPA review by staff within the Office
of Health and Environmental Assessment and the Office of Water. Selected documents
are reviewed by the Science Advisory Board and are subject to peer review workshops
and public comments. DWCDs become part of the Safe Drinking Water (SOW) public
docket and final drafts are available through NTIS.
B. Selection Criteria and Sources of HEAST Values
Chemicals with derived noncarcinogenic and/or carcinogen risk assessment values
that have had some level of peer review (i.e., those in peer reviewed EPA documents
or under review by EPA Work Groups) are included in HEAST; this does not include
many interim values (values not found in final EPA documents or not being considered
by Work Groups) derived for various purposes within Superfund and other Program
Offices. In updating the HEAST, the first source that is checked is the Integrated Risk
Information System (IRIS) for revised or newly added risk assessment values.
Secondly, the status of chemicals under discussion by the RfD/RfC and CRAVE Work
Groups is reviewed. The National Center for Environmental Assessment's Chemical
Assessments and Related Activities (CARA) list is also reviewed for new Office of
Water, Office of Air Quality Planning and Standards, and Office of Solid Waste and
Emergency Response risk assessment documents (HEEDs, HEEPs, HEAs, HADs,
AQCDs, DWCDs).
The HEAST also contains chemicals commonly found at RCRA (Resource
Conservation and Recovery Act) sites as identified by the Office of Solid Waste's
Technical Assessment Branch. Questions about RCRA chemicals may be addressed
by calling the Health Assessment Section (Office of Solid Waste) at (202) 260-4761.
Finally, the Office of Radiation Programs provides data on radionuclides for Table 4 of
the HEAST. Radionuclides included are those thought to be most commonly
encountered at Superfund sites. Questions concerning radionuclides carcinogenicity
should first be addressed by contacting the appropriate Regional Radiation Program
Manager. A listing of these managers and several contacts in the Office of Radiation
Programs can be found in Exhibit 2 of the User's Guide -Radionuclide Carcinogenicity.
A-5
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APPENDIX A-ll
A-6
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APPENDIX A-ll
II. DOSE CONVERSIONS ON HEAST
In January 1991, the decision was made to replace inhalation Reference Doses
(RfDi) for noncancer toxicity and inhalation slope factors for carcinogenicity, previously
available on the IRIS data base, with Reference Concentrations (RFC) and inhalation
unit risks, respectively. RfCs and unit risks are expressed in terms of concentration in
air (mg/m3), not in terms of "dose" (mg/kg-day) like the RfDs and the oral and inhalation
slope factors. This presents a problem for the Superfund program, since the current
Hazard Ranking System (MRS) and the Risk Assessment Guidance for superfund
(RAGS): Human Health Evaluation manual, Parts A and B were developed using
chronic daily intakes and health criteria expressed in units of mg/kg-day.
The decision to replace inhalation slope factors and RfDi values expressed in
mg/kg-day with unit risk and RfC values expressed in mg/m3 was based on two major
factors: 1) the workgroups felt that it was technically more accurate to base toxicity
values directly on measured air concentrations instead of making the metabolic
pharmacokinetic and/or surface area adjustments required to estimate an "internal
dose"; and 2) there are compounds that elicit route-of-entry effects (e.g., sensitizers
and irritants) where the toxic effect is to the respiratory system or exchange boundary
where a measure of "internal dose" might inappropriately imply effects to other organ
systems or effects from other exposure routes.
Superfund recognizes the importance of these issues and is actively working
with EPA's Office of Research and Development to evaluate the impact of these
changes on its program regulations and guidance. In the short term, however,
modification of program regulations and guidance is not a viable option. Therefore, the
chairs of the RfD/RfC and CRAVE Work Groups were consulted regarding Superfund's
need to make the conversion from a concentration in air to dose. There was agreement
that, in many cases, converting the air concentration data to a dose (in mg/kg-day) may
not add significant uncertainty to the Superfund risk assessment process, and therefore
may be a reasonable use of the data given appropriate circumstances and Superfund
program objectives.
Generally, the Superfund Health Risk Technical Support Center will be
responsible for making all appropriate conversions and the values will be identified with
appropriate highlights or footnotes in the Health Effects Assessment Summary Tables
(HEAST). Therefore, HEAST users are strongly advised against making such
conversions themselves. However, it is a critical responsibility of the risk assessor to
consult the original reports cited in the HEAST and to appropriately characterize or
caveat the resulting risk estimates derived from these values so that managers are fully
informed of their origin and related uncertainties.
A-7
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APPENDIX A-lll
III. CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE
REGISTRY NUMBER CROSS REFERENCE
This section lists chemicals and their respective Chemical Abstracts Service
Registry Number (CASRN) for cross referencing. Chemicals may be searched either
alphabetically by compound name or numerically by the CASRN.
The list has been updated to only include chemicals that are currently
documented in this issue of the HEAST.
A-8
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CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME)
July 1997
ACENAPHTHENE 000083-32-9
ACENAPTHYLENE 000208-96-8
ACEPHATE 030560-19-1
ACETONE 000067-64-1
ACETONE CYANOHYDRIN 000075-86-5
ACETONITRILE 000075-05-8
ACETOPHENONE 000098-86-2
ACROLEIN 000107-02-8
ACRYLAMIDE 000079-06-1
ACRYLIC ACID 000079-10-7
ACRYLONITRILE 000107-13-1
ADIPONITRILE 000111-69-3
ALACHLOR 015972-60-8
ALDICARB 000116-06-3
ALDRIN 000309-00-2
ALLIDOCHLOR 000093-71-0
ALLYL ALCOHOL 000107-18-6
ALLYL CHLORIDE 000107-05-1
ALUMINUM 007429-90-5
ALUMINUM PHOSPHIDE 020859-73-8
AMETRYN 000834-12-8
AMINO-2-NAPHTHOL, 1- 002834-92-6
AMINO-2-NAPHTOL HYDROCHLORIDE, 1- 001198-27-2
AMINOPHENOL, M- 000591-27-5
AMINOPHENOL, 0- 000095-55-6
AMINOPHENOL, P- 000123-30-8
AMINOPYRIDINE, 4- 000504-24-5
AMMONIA 007664-41-7
ANILINE 000062-53-3
ANTHRACENE 000120-12-7
ANTIMONY, METALLIC 007440-36-0
ANTIMONY PENTOXIDE 001314-60-9
ANTIMONY POTASSIUM TARTRATE 000304-61-0
ANTIMONY TETROXIDE 001332-81-6
ANTIMONY TRIOXIDE 001309-64-4
ARAMITE 000140-57-8
AROCLOR 1248 012672-29-6
AROCLOR 1254 011097-69-1
ARSENIC, INORGANIC 007440-38-2
ASBESTOS 001332-21-4
ATRAZINE 001912-24-9
AZOBENZENE 000103-33-3
BARIUM 007440-39-3
BARIUM CYANIDE 000542-62-1
BENEFIN 001861-40-1
BENZAL CHLORIDE 000098-87-3
BENZALDEHYDE 000100-52-7
BENZALDEHYDE CYANOHYDRIN 000532-28-5
BENZENE 000071-43-2
BENZENETHIOL / (THIOPHENOL) 000108-98-5
BENZIDINE 000092-87-5
BENZOIC ACID 000065-85-0
BENZOTRICHLORIDE 000098-07-7
BENZO[A]ANTHRACENE 000056-55-3
BENZO[A]PYRENE 000050-32-8
BENZOMFLUORANTHENE 000207-08-9
BENZYL ALCOHOL 000100-51-6
BENZYL CHLORIDE 000100-44-7
BERYLLIUM 007440-41-7
BIPHENYL, 1,1' 000092-52-4
BIS(2-CHLOROETHYL) ETHER 000111-44-4
BIS(2-CHLOROISOPROPYL) ETHER 039638-32-9
BISC2-CHLORO-1-METHYLETHYL) ETHER 000108-60-1
BISC2-ETHYLHEXYL) PHTHALATE / (DEHP)000117-81-7
BIS(CHLOROMETHYL) ETHER 000542-88-1
BISPHENOL A 000080-05-7
BORON, ELEMENTAL 007440-42-8
BORON TRIFLUORIDE 007637-07-2
BROMINATED DIBENZO-P-DIOXINS NO CASRN
BROMINATED DIBENZOFURANS NO CASRN
BROMOACETONE 000598-31-2
BROMOCHLOROETHANES NO CASRN
BROMODICHLOROMETHANE 000075-27-4
BROMOETHENE / (VINYL BROMIDE) 000593-60-2
BROMOFORM 000075-25-2
BROMOMETHANE 000074-83-9
BROMOPHENYL PHENYL ETHER, 4- 000101-55-3
BROMOPHOS 002104-96-3
BROMOXYNIL 001689-84-5
BROMOXYNIL OCTANOATE 001689-99-2
BUSAN 77 031512-74-0
BUSAN 90 002491-38-5
BUTADIENE, 1,3- 000106-99-0
BUTANOL, 1- 000071-36-3
BUTYL BENZYL PHTHALATE, N- 000085-68-7
BUTYLATE 002008-41-5
BUTYLCHLORIDE, T- 000507-20-0
BUTYROLACTONE, GAMMA- 000096-48-0
CACODYLIC ACID 000075-60-5
CADMIUM 007440-43-9
CALCIUM CYANIDE 000592-01-8
CAPROLACTAM 000105-60-2
CAPTAFOL 002425-06-1
CAPTAN 000133-06-2
CARBARYL 000063-25-2
CARBAZOLE 000086-74-8
CARBOFURAN 001563-66-2
CARBON DISULFIDE 000075-15-0
CARBON MONOXIDE 000630-05-0
CARBON TETRACHLORIDE 000056-23-5
CHLORAL 000075-87-6
CHLORANIL 000118-75-2
CHLORDANE 000057-74-9
CHLORINE CYANIDE 000506-77-4
CHLORO-1.3-BUTADIENE, 2- / (CHLOROPRENE)
000126-99-8
CHLORO-2-METHYLANILINE, 4- 000095-69-2
CHLORO-2-METHYLANILINE HYDROCHLORIDE, 4-
003165
CHLORO-M-CRESOL, P-
CHLOROACETALDEHYDE
CHLOROACETIC ACID
CHLOROANILINE, 2-
CHLOROANILINE, 3-
CHLOROANILINE, 4-
CHLOROBENZENE
CHLOROBENZILATE
CHLOROBENZOIC ACID, P-
CHLOROBENZOTRIFLUORIDE, 4-
CHLOROBUTANE, 1-
CHLOROBUTANE, 2-
CHLOROCYCLOPENTADIENE
CHLOROFORM
CHLOROMETHANE / (METHYL CHLORIDE)
CHLOROMETHYL METHYL ETHER
CHLORONITROBENZENE, K-
CHLORONITROBENZENE, 0-
CHLORONITROBENZENE, P-
CHLOROPHENOL, 2-
CHLOROPHENOL, 3-
CHLOROPHENOL, 4-
CHLOROPRENE
CHLOROPROPANE, 2-
CHLOROTHALONIL
CHLOROTOLUENE, M-
CHLOROTOLUENE, 0-
CHLOROTOLUENE, P-
CHLORPYRIFOS
CHLORPYRIFOS METHYL
CHLORTHIOPHOS
CHROMIUM(III)
CHROMIUM(VI)
CHRYSENE
COKE OVEN EMISSIONS
COPPER
COPPER CYANIDE
CREOSOTE, COAL TAR
CRESOL, M- / (3-METHYLPHENOL)
CRESOL, 0- / (2-METHYLPHENOL)
CRESOL, P- / (4-METHYLPHENOL)
000059
000107
000079
000095
000108
000106
000108
000510
000074
000098
000109
000078
041851
000067
000074
000107
000121
000088
000100
000095
000108
000106
000126
000075
001897
000108
000095
000106
002921
005598
060238
016065
018540
000218
008007
007440
000544
008001
000108
000095
000106
93-3
50-7
20-0
11-8
51-2
42-9
47-8
90-7
15-6
11-3
56-6
69-3
86-4
50-7
66-3
87-3
30-2
73-3
73-3
00-5
57-8
43-0
48-9
99-8
29-6
45-6
41-8
49-8
43-4
88-2
13-0
56-4
83-1
29-9
01-9
45-2
50-8
92-3
58-9
39-4
48-7
44-5
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME) Continued
July 1997
I
o
CROTONALOEHYDE
CUMENE
CYANA2INE
CYANIDE
CYANOGEN
CYANOGEN BROMIDE
CYCLOATE
CYCLOHEXANOL
CYCLOHEXYLAMINE
CYCLONITE
CYCLOPENTADIENE
DACTHAL
DALAPON
2,4-DB
DDD
DDE
DDT
DECABROMODIPHENYL ETHER
DEHP
DJ-N-OCTYL PHTHALATE
DIALLATE
DIAZINON
DIBENZOFURAN
D1BENZO[A,H]ANTHRACENE
DIBROMO-3-CHLOROPROPANE, 1,2
DIBROMOBENZENE, 1,4-
DIBROMOCHLOROMETHANE
DIBROMOETHANE, 1,2-
DIBUTYL PHTHALATE
DICAMBA
DICHLORO-2-BUTENE, 1,4-
DICHLOROBENZENE, 1,2-
DICHLOROBENZENE, 1,3-
DICHLOROBENZENE, 1,4-
DICHLOROBENZID1NE, 3,3'-
DICHLOROBUTENES
DICHLORODIFLUOROMETHANE
DICHLOROETHANE, 1,1-
DICHLOROETHYLENE, 1,1-
DICHLOROETHYLENE, 1,2- (MIXED
DICHLOROETHYLENE, 1,2-C-
DICHLOROETHYLENE, 1,2-T-
DICHLOROMETHANE
D1CHLOROPHENOL, 2,3-
DICHLOROPHENOL, 2,4-
DICHLOROPHENOL, 2,5-
DICHLOROPHENOL, 2,6-
DICHLOROPHENOL, 3,4-
000123-73-9
000098-82-8
021725-46-2
000057-12-5
000460-19-5
000506-68-3
001134-23-2
000108-93-0
000108-91-8
000121-82-4
000542-92-7
001861-32-1
000075-99-0
000094-82-6
000072-54-8
000072-55-9
000050-29-3
001163-19-5
000117-81-7
000117-84-0
002303-16-4
000333-41-5
000132-64-9
000053-70-3
000096-12-8
000106-37-6
000124-48-1
000106-93-4
000084-74-2
001918-00-9
000764-41-0
000095-50-1
000541-73-1
000106-46-7
000091-94-1
NO CASRN
000075-71-8
000075-34-3
000075-35-4
ISOMERS)
000540-59-0
000156-59-2
000156-60-5
000075-09-2
000576-24-9
000120-83-2
000583-78-8
000087-65-0
000095-77-2
DICHLOROPHENOL, 3,5-
DICHLOROPHENOXY ACETIC ACID, 2,4-
DICHLOROPHENOXY) BUTYRIC ACID, 4-(2,
(2,4-DB)
DICHLOROPROPANE, 1,1-
DICHLOROPROPANE, 1,2-
DICHLOROPROPANE, 1,3-
DICHLOROPROPANE, 2,2-
DICHLOROPROPENE, 1,3- / (TELONE II)
DICHLORPROP
DICYCLOPENTADIENE
DIELDRIN
DIETHYL-P-NITROPHENYL PHOSPHATE
DIETHYL PHTHALATE
DIETHYLANILINE, N,N-
DIETHYLENE GLYCOL HONOBUTYL ETHER
DIETHYLENE GLYCOL HONOETHYL ETHER
DIETHYLFORMAHIDE
DIETHYLHYDRAZINE, 1,2-
DIETHYLSTILBESTROL
DIHETHOATE
DIHETHOXYBENZIDINE, 3,3'-
DIMETHYLANILINE, 2,4-
DIMETHYLANILINE HYDROCHLORIDE, 2,4-
DIMETHYLANILINE, N,N-
DIMETHYLBENZIDINE, 3,3'-
DIMETHYLFORMAMIDE, N,N-
DIHETHYLHYDRAZINE, 1,1-
DIMETHYLHYDRAZINE, 1,2-
DIMETHYLPHENOL, 2,3-
DIMETHYLPHENOL, 2,4-
DIMETHYLPHENOL, 2,5-
DIMETHYLPHENOL, 2,6-
DIMETHYLPHENOL, 3,4-
DIHETHYLPHTHALATE
DIMETHYLSULFATE
DIHETHYLTEREPHTHALATE
DIMETHYLUREA, N,N-
DINITRO-0-CRESOL, 4,6-
DINITRO-P-CRESOL, 2,6-
DINITROBENZENE, 1,2-
DINITROBENZENE, 1,3-
DINITROBENZENE, 1,4-
DINITROPHENOL, 2,3-
DINITROPHENOL, 2,4-
DINITROPHENOL, 2,5-
DINITROPHENOL, 2,6-
DINITROPHENOL, 3,5-
DINITROTOLUENE, 2,3-
000591-35-5 DINITROTOLUENE, 2,4 000121-14-2
000094-75-7 DINITROTOLUENE, 2,5- 000619-15-8
4- / DINITROTOLUENE, 2,6- 000606-20-2
000094-82-6 DINITROTOLUENE, 3,4- 000610-39-9
000078-99-9 DINOSEB 000088-85-7
000078-87-5 DIOXANE, 1,4- 000123-91-1
000142-28-9 DIPHENYLAMINE, N,N- 000122-39-4
000594-20-7 DIPHENYLHYDRAZINE, 1,2- 000122-66-7
000542-75-6 DIPHENYLMETHANE DIISOCYANATE 000101-68-8
000120-36-5 DIRECT BLACK 38 001937-37-7
000077-73-6 DIRECT BLUE 6 002602-46-2
000060-57-1 DIRECT BROWN 95 016071-86-6
000311-45-5 DIRECT LIGHTFAST BLUE 004399-55-7
000084-66-2 DIRECT SKY BLUE 68 002610-05-1
000091-66-7 DISULFOTON 000298-04-4
000112-34-5 ENDOSULFAN 000115-29-7
000111-90-0 ENDOTHALL 000145-73-3
000617-84-5 EMDRIN 000072-20-8
001615-80-1 EPICHLOROHYDRIN 000106-89-8
000056-53-1 EPTC 000759-94-4
000060-51-5 ETHOPROP 013194-48-4
000119-90-4 ETHOXYETHANOL, 2- 000110-80-5
000095-68-1 ETHOXYETHANOL ACETATE, 2- 000111-15-9
021436-96-4 ETHOXYETHANOL ACRYLATE, 2- 000106-74-1
000121-69-7 ETHOXYETHANOL DODECANOATE, 2- 000106-13-8
000119-93-7 ETHOXYETHANOL PHOSPHATE, 2- 068554-00-7
000068-12-2 ETHOXYETHYL METHACRYLATE, 2- 002370-63-0
000057-14-7 ETHYL ACETATE 000141-78-6
000540-73-8 ETHYL ACRYLATE 000140-B8-5
000526-75-0 ETHYL BENZENE 000100-41-4
000105-67-9 ETHYL CHLORIDE 000075-00-3
000095-87-4 ETHYL ETHER 000060-29-7
000576-26-1 ETHYL HETHACRYLATE 000097-63-2
000095-65-8 ETHYL-0-XYLENE, 4- 000934-80-5
000131-11-3 ETHYLANILINE, N- 000103-69-5
000077-78-1 ETHYLENE CYANOHYDRIN 000109-78-4
000120-61-6 ETHYLENE DIAMINE 000107-15-3
000598-94-7 ETHYLENE GLYCOL 000107-21-1
000534-52-1 ETHYLENE GLYCOL MONOBUTYL ETHER 000111-76-2
000609-93-8 ETHYLENE OXIDE 000075-21-8
000528-29-0 ETHYLENE THIOUREA 000096-45-7
000099-65-0 ETHYLTOLUENE, M- 000620-14-4
000100-25-4 ETHYLTOLUENE, 0- 000611-14-3
000066-56-8 ETHYLTOLUENE, P- 000622-96-8
000051-28-5 FLUORANTHENE 000206-44-0
000329-71-5 FLUORENE 000086-73-7
000573-56-8 FLUORINE / (SOLUBLE FLUORIDE) 007782-41-4
000586-11-8 FLURIDONE 059756-60-4
000602-01-7 FOLPET 000133-07-3
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME) Continued
July t997
FORMALDEHYDE 000050-00-0
FORMALDEHYDE CYANOHYDRIN 000107-16-4
FORMIC ACID 000064-18-6
FURAN 000110-00-9
FURAZOUDONE 000067-45-8
FURFURAL 000098-01-1
FURIUM 000531-82-8
GLYCIDALDEHYDE 000765-34-4
HEPTACHLOR 000076-44-8
HEPTACHLOR EPOXIDE 001024-57-3
HEPTANE, M- 000142-82-5
HEXABROMOBENZENE 000087-82-1
HEXACHLOROBENZENE 000118-74-1
HEXACHLOROBUTADIENE 000087-68-3
HEXACHLOROCYCLOHEXANE, ALPHA- 000319-84-6
HEXACHLOROCYCLOHEXANE, BETA- 000319-85-7
HEXACHLOROCYCLOHEXANE, DELTA- 000319-86-8
HEXACHLOROCYCLOHEXANE, EPSILON- 006108-10-7
HEXACHLOROCYCLOHEXANE, GAMMA- 000058-89-9
HEXACHLOROCYCLOHEXANE-TECHN1CAL 000608-73-1
HEXACHLOROCYCLOPENTADIENE 000077-47-4
HEXACHLOROETHANE 000067-72-1
HEXACHLOROPHENE 000070-30-4
HEXAMETHYLENE OIAMINE 000124-09-4
HEXANE, N- 000110-54-3
HEXANONE, 2- 000591-78-6
HYDRAZ1NE 000302-01-2
HYDRAZINE SULFATE 010034-93-2
HYDROGEN SULFIDE 007783-06-4
HYOROQUINONE 000123-31-9
INDENOC1,2,3-CD]PYRENE 000193-39-5
IRON 007439-89-6
ISOBUTYL ALCOHOL 000078-83-1
ISOPHORONE 000078-59-1
ISOPROPALIN 033820-53-0
LACTONITRILE 000078-97-7
LEAD 007439-92-1
LEAD ALKYLS NO CASRN
LINURON 000330-55-2
MALATHION 000121-75-5
MALEIC ANHYDRIDE 000108-31-6
MALEIC HYORAZIDE 000123-33-1
MALONONITRILE 000109-77-3
MANCOZEB 008018-01-7
MANEB 012427-38-2
MANGANESE 007439-96-5
MEPHOSFOLAN 000950-10-7
MERCURIC CHLORIDE 007487-94-7
MERCURY, ELEMENTAL 007439-97-6
MERPHOS
MERPHOS OXIDE
METHACRYLONITRILE
METHANOL
METHOMYL
METHOXY-5-NITROANILINE, 2-
METHOXYCHLOR
METHOXYETHANOL, 2-
METHOXYETHANOL ACETATE, 2-
000150-50-5
000078-48-B
000126-98-7
000067-56-1
016752-77-5
000099-59-2
000072-43-5
000109-86-4
000110-49-6
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2-
000094-81-5
METHYL-4-CHLOROPHENOXY) PROPIONIC ACID, 2-(2-
000093-65-2
METHYL-4-CHLOROPHENOXY ACETIC ACID, 2-
000094-74-6
000099-55-8
000079-20-9
000096-33-3
000074-87-3
000079-22-1
000078-93-3
001338-23-4
METHYL-5-N1TROANIL1NE, 2-
METHYL ACETATE
METHYL ACRYLATE
METHYL CHLORIDE
METHYL CHLOROCARBONATE
METHYL ETHYL KETONE
METHYL ETHYL KETONE PEROXIDE
METHYL HYDRAZINE 000060-34-4
METHYL ISOBUTYL KETONE 000108-10-1
METHYL ISOCYANATE 000624-83-9
METHYL MERCURY 022967-92-6
METHYL METHACRYLATE 000080-62-6
METHYL PARATHION 000298-00-0
METHYL STYRENE (MIXED ISOMERS) 025013-15-4
METHYL STYRENE, ALPHA 000098-83-9
METHYLANILINE, 2- 000095-53-4
METHYLANILINE HYDROCHLORIDE, 2- 000636-21-5
METHYLCYCLOHEXANE 000108-87-2
METHYLENE-BIS(2-CHLOROANILINE), 4,4'-
000101-14-4
METHYLENE-BIS(N,N'-DIMETHYLJANILINE, 4,4'-
000101-61-1
METHYLENE BROMIDE 000074-95-3
METHYLENE CHLORIDE / (DICHLOROMETHANE)
000075-09-2
METHYLENE-BIS(BENZENEAMINE), 4,4- /
(METHYLENE OIANILINE, 4,4-) 000101-77-9
METHYLENEDIPHENYL ISOCYANATE, 4,4- /
(D1PHENYLMETHANE DIISOCYANATE) 000101-68-8
2-METHYLLACTONITRILE 000075-86-5
2-METHYLPHENOL 000095-48-7
3-METHYLPHENOL 000108-39-4
4-METHYLPHENOL 000106-44-5
METOLACHLOR 051218-45-2
METRIBUZIN
MIREX
MOL1NATE
MOLYBDENUM
MONOCHLORAMINE
NAPHTHALENE
NAPHTHOQUINONE, 1,4-
NIAGARA BLUE 4B
NICKEL CYANIDE
NIC
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME) Continued
July 1997
PEN0IMETHALIN
PENTABROMO-6-CHLOROCYCLOHEXANE, 1,2,
PENTABROMOOIPHENYL ETHER
PENTACHLOROBENZENE
PENTACHLOROCYCLQPENTAD1ENE
PENTACHLORONITROBENZENE
PENTACHLOROPHENOL
PENTACHLOROPROPENE, 1,1,2,3,3,-
PENTANE, N-
PHENANTHRENE
PHEMOL
PHENYLENEDIAMINE, M-
PHENYLENEDIAMINE, 0-
PHENYLENEDIAMINE, P-
PHENYLMERCURIC ACETATE
PHENYLPHENOL, 2-
PHORATE
PHOSGENE
PHOSPHINE
PHOSPHORUS, WHITE
PHOTOCHEMICAL OXIDANTS
PHTHALIC ACID, M-
PHTHALIC ACID, 0-
PHTHAL1C ACID, P-
PHTHALIC ANHYDRIDE
POLYBROMINATED BIPHENYLS
POLYCHLORINATED BIPHENYLS
POTASSIUM CYANIDE
POTASSIUM SILVER CYANIDE
PROFLURALIN
PRONAMIDE
PROPACHLOR
PRQPAZINE
PROP10NITRILE
PROPYL ALCOHOL, N-
PROPYLENE GLYCOL
PROPYLENE GLYCOL MONOETHYL ETHER
PROPYLENE GLYCOL MONOMETHYL ETHER
PROPYLENE OXIDE
PYRENE
PYRIDINE
QUINOLINE
RDX / (CYCLONITE)
RONNEL
SELENIOUS ACID
SELENIUM
040487-42-1 SELENIUM SULFIDE 007446-34-6
3,4,5- SELENOUREA 000630-10-4
000087-84-3 SILVER 007440-22-4
032534-81-9 SILVER CYANIDE 000506-64-9
000608-93-5 SIMAZINE 000122-34-9
025329-35-5 SODIUM CYANIDE 000143-33-9
000082-68-8 SODIUM DIETHYLDITHIOCARBAHATE 000148-18-5
000087-86-5 SODIUM METAVANADATE 013718-26-8
001600-37-9 STIROPHOS 000961-11-5
000109-66-0 STRONTIUM, STABLE 007440-24-6
000085-01-8 STRYCHNINE 000057-24-9
000108-95-2 STYRENE 000100-42-5
000108-45-2 SUCCINONITRILE 000110-61-2
000095-54-5 SULFUR DIOXIDE 007446-09-5
000106-50-3 SULFUR OXIDES HO CASRN
000062-38-4 SULFURIC ACID 007664-93-9
000090-43-7 TCDD, 2,3,7,8- 001746-01-6
000298-02-2 TELONE II 000542-75-6
000075-44-5 TEHEPHOS 003383-96-8
007803-51-2 TERBUFOS 013071-79-9
007723-14-0 TEREPHTHALIC ACID 000100-21-0
NO CASRN TETRACHLOROA20XYBENZENE 021232-47-3
000121-91-5 TETRACHLOROBENZENE, 1,2,4,5- 000095-94-3
000088-99-3 TETRACHLOROCYCLOPENTADIENE 000695-77-2
000100-21-0 TETRACHLOROETHANE, 1,1,1,2- 000630-20-6
000085-44-9 TETRACHLOROETHANE, 1,1,2,2- 000079-34-5
NO CASRN TETRAGHLOROETHYLENE 000127-18-4
001336-36-3 TETRACHLOROHYDRAZOBENZEME 071753-42-9
000151-50-8 TETRACHLOROPHENOL, 2,3,4,5- 004901-51-3
000506-61-6 TETRACHLOROPHENOL, 2,3,4,6- 000058-90-2
026399-36-0 TETRACHLOROPHENOL, 2,3,5,6- 000935-95-5
023950-58-5 TETRACHLOROPROPENE, 1,1,2,3- 010436-39-2
001918-16-7 TETRACHLOROTOLUENE, PARA, ALPHA, ALPHA, ALPHA-
000139-40-2 005216-25-1
000107-12-0 TETRACHtOROVINPHOS / (STIROPHOS) 000961-11-5
000071-23-8 TETRAETHYL DITHIOPYROPHOSPHATE 003689-24-5
000057-55-6 THALLIC OXIDE 001314-32-5
THALLIUM (I> ACETATE 000563-68-8
001569-02-4 THALLIUM (1) CARBONATE 006533-73-9
THALLIUM (I> CHLORIDE 007791-12-0
000107-98-2 THALLIUM, INSOLUBLE SALTS NO CASRN
000075-56-9
000129-00-0 THALLIUM (I) NITRATE 010102-45-1
000110-86-1 THALLIUM SELENITE 012039-52-0
000091-22-5 THALLIUM (I) SULFATE 007446-18-6
000121-82-4 THIOCYANOMETHYLTHIO)BENZOTHIAZOLE, 2-(
000299-84-3 021564-17-0
007783-00-8 THIOFANOX 013196-18-4
007782-49-2 THIOPHENOL 000108-98-5
THIRAM
TIN AMD COMPOUNDS
TOLUENE
TOLUENE-2.4-DIAM1NE
TOLUENE-2,5-DIAMINE
TOLUENE-2,6-DIAMINE
TOLUENEDIAMINE, 2,3-
TOLUENEDIAMINE, 3,4-
TOLUIDINE, M-
TOLUIDIME, P-
TOXAPHENE
TRIALLATE
TRIBROMOBENZENE, 1,2,4-
TRICHLORO-1,2,2-TRIFLUOROETHANE, 1
TRICHLORO-2'-HYDROXYDIPHENYLETHER,
TRICHLOROANILINE, 2,4,6-
TRICHLOROANILINE HYDROCHLQRIDE, 2,
TRICHLOROBENZENE, 1,2,4-
TRICHLOROCYCLOPENTADIENE
TRICHLOROETHANE, 1,1,1-
TRICHLOROETHANE, 1,1,2-
TRICHLOROETHYLENE
TRICHLOROFLUOROMETHANE
TR1CHLOROPHENOL, 2,3,4-
TRICHLOROPHENOL, 2,3,5-
TRICHLOROPHENOL, 2,3,6-
TRICHLOROPHENOL, 2,4,5-
TRICHLOROPHENOL, 2,4,6-
TRICHLOROPHENOL, 3,4,5-
TRICHLOROPHENOXY) PROPIONIC ACID,
TR1CHLOROPHENOXY ACETIC ACID, 2,4,
TR1CHLOROPROPANE, 1,1,1-
TRICHLOROPROPANE, 1,1,2-
TRICHLOROPROPANE, 1,2,2-
TRICHLOROPROPANE, 1,2,3-
TRICHLOROPROPENE, 1,2,3-
TRICHLOROTOLUENE, 2,3,6-
TRICHLOROTOLUENE, ALPHA,2,6-
TRIFLURALIN
TRJMETHYL PHOSPHATE
TRIMETHYLBENZENES
TRINITROSENZENE, 1,3,5-
TRINITROPHENOLS
TRINITROPHENYLMETHYLNITRAMINE
000137-26-8
NO CASRN
000108-88-3
000095-80-7
000095-70-5
000823-40-5
002687-25-4
000496-72-0
000108-44-1
000106-49-0
008001-35-2
002303-17-5
000615-54-3
,1,2-
000076-13-1
2,2,4'-
003380-34-5
000634-93-5
4,6-
033663-50-2
000120-82-1
077323-84-3
000071-55-6
000079-00-5
000079-01-6
000075-69-4
015950-66-0
000933-78-8
000933-75-5
000095-95-4
000088-06-2
000609-19-8
2(2,4,5-
000093-72-1
5-
000093-76-5
007789-89-1
000598-77-6
003175-23-3
000096-18-4
000096-19-5
002077-46-5
002014-83-7
001582-09-8
000512-56-1
NO CASRN
000099-35-4
NO CASRN
000479-45-8
-------
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY NAME) Continued July 1997
TRINITROTOLUENE, 2,4,6- 000118-96-7
VANADIUM 007440-62-2
VANADIUM PENTOXIDE 001314-62-1
VANADIUM SULFATE 036907-42-3
VERNAM / (VERNOLATE) 001929-77-7
VERNOLATE 001929-77-7
VINYL-1-CYCLOHEXENE, 4- 000100-40-3
VINYL ACETATE 000108-05-4
VINYL BROMIDE 000593-60-2
VINYL CHLORIDE 000075-01-4
WARFARIN 000081-81-2
XYLENE, M- 000108-38-3
XYLENE, MIXTURE 001330-20-7
XYLENE, 0- 000095-47-6
XYLENE, P- 000106-42-3
ZINC (METALLIC) 007440-66-6
ZINC CYANIDE 000557-21-1
ZINC PHOSPHIDE 001314-84-7
ZINEB 012122-67-7
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER)
I
£
000050-00-0 FORMALDEHYDE 000074-95-3
000050-29-3 DDT 000075-00-3
000050-32-8 BENZOCAJPYRENE 000075-01-4
000051-28-5 DINITROPHENOL, 2,4- 000075-05-8
000053-70-3 DIBENZO[A,H]ANTHRACENE 000075-09-2
000055-18-5 N1TROSODIETHYLAMINE, N- 000075-09-2
000056-23-5 CARBON TETRACHLOR1DE 000075-15-0
000056-38-2 PARATHION 000075-21-8
000056-53-1 DIETHYLSTILBESTROL 000075-25-2
000056-55-3 BENZO [A]ANTHRACENE 000075-27-4
000057-12-5 CYANIDE 000075-29-6
000057-14-7 DIMETHYLHYDRAZINE, 1,1- 000075-34-3
000057-24-9 STRYCHNINE 000075-35-4
000057-55-6 PROPYLENE GLYCOL 000075-44-5
000057-74-9 CHLORDANE 000075-52-5
000058-89-9 HEXACHLOROCYCLOHEXANE, GAMMA- 000075-56-9
000058-90-2 TETRACHLOROPHENOL, 2,3,4,6- 000075-60-5
000059-50-7 CHLORO-M-CRESOL, P- 000075-69-4
000059-87-0 NITROFURAZONE 000075-71-8
000060-29-7 ETHYL ETHER 000075-86-5
000060-34-4 METHYL HYDRAZINE 000075-86-5
000060-51-5 D1METHOATE 000075-87-6
000060-57-1 DIELDRIN 000075-99-0
000062-38-4 PHENYLMERCURIC ACETATE 000076-13-1
000062-53-3 ANILINE TRICHLORO-
000062-75-9 NITROSODIMETHYLAMINE, N- 000076-44-8
000063-25-2 CARBARYL 000077-47-4
000064-18-6 FORMIC ACID 000077-73-6
000065-85-0 BENZOIC ACID 000077-78-1
000066-56-8 DINITROPHENOL, 2,3- 000078-48-8
000067-20-9 NITROFURANTOIN 000078-59-1
000067-45-8 FURAZOLIDONE 000078-83-1
000067-56-1 METHANOL 000078-86-4
000067-64-1 ACETONE 000078-87-5
000067-66-3 CHLOROFORM 000078-93-3
000067-72-1 HEXACHLOROETHANE 000078-97-7
000068-12-2 DIMETHYLFORMAMIDE, N,N- 000078-99-9
000070-30-4 HEXACHLOROPHENE 000079-00-5
000071-23-8 PROPYL ALCOHOL, N- 000079-01-6
000071-36-3 BUTANOL, 1- 000079-06-1
000071-43-2 BENZENE 000079-10-7
000071-55-6 TRICHLOROETHANE, 1,1,1- 000079-11-8
000072-20-8 ENDR1N 000079-20-9
000072-43-5 METHOXYCHLOR 000079-22-1
000072-54-8 ODD 000079-34-5
000072-55-9 DDE 000079-46-9
000074-11-3 CHLOROBENZOIC ACID, P- 000080-05-7
000074-83-9 BROMOMETHANE 000080-62-6
000074-87-3 METHYL CHLORIDE 000081-81-2
000074-87-3 CHLOROMETHANE 000082-68-8
METHYLENE BROMIDE
ETHYL CHLORIDE
VINYL CHLORIDE
ACETONITRILE
METHYLENE CHLORIDE
DICHLOROMETHANE
CARBON DISULFIDE
ETHYLENE OXIDE
BROMOFORM
BROMODICHLOROMETHANE
CHLOROPROPANE, 2-
DICHLOROETHANE, 1,1-
DICHLOROETHYLENE, 1,1-
PHOSGENE
NITROMETHANE
PROPYLENE OXIDE
CACODYLIC ACID
TRICHLOROF LUOROMET HANE
DICHLORODIFLUOROMETHANE
2-METHYLLACTONITRILE
ACETONE CYANOHYDRIN
CHLORAL
DALAPON
1,2,2-TRIFLUOROETHANE, 1,1,2-
HEPTACHLOR
HEXACHLOROCYCLOPENTADIENE
DICYCLOPENTADIENE
DIMETHYLSULFATE
MERPHOS OXIDE
ISOPHORONE
ISOBUTYL ALCOHOL
CHLOROBUTANE, 2-
DICHLOROPROPANE, 1,2-
METHYL ETHYL KETONE
LACTONITRILE
DICHLOROPROPANE, 1,1-
TRICHLOROETHANE, 1,1,2-
TRICHLOROETHYLENE
ACRYLAMIDE
ACRYLIC ACID
CHLOROACETIC ACID
METHYL ACETATE
METHYL CHLOROCARBONATE
TETRACHLOROETHANE, 1,1,2,2-
NITROPROPANE, 2-
BISPHENOL A
METHYL METHACRYLATE
WARFARIN
PENTACHLORONITROBENZENE
000083-32-9
000084-66-2
000084-74-2
000085-01-8
000085-44-9
000085-68-7
000086-30-6
000086-73-7
000086-74-8
000087-65-0
000087-68-3
000087-82-1
July 1997
ACENAPHTHENE
DIETHYL PHTHALATE
DI BUTYL PHTHALATE
PHENANTHRENE
PHTHALIC ANHYDRIDE
BUTYL BENZYL PHTHALATE, N-
NITROSODIPHENYLAMINE, N-
FLUORENE
CARBAZOLE
DICHLOROPHENOL, 2,6-
HEXACHLOROBUTAD IENE
HEXABROMOBENZENE
000087-84-3
PENTABROMO-6-CHLOROCYCLOHEXANE, 1,2,3,4,5-
000087-86-5
000088-06-2
000088-72-2
000088-73-3
000088-74-4
000088-85-7
000088-99-3
000090-43-7
000091-20-3
000091-22-5
000091-66-7
000091-94-1
000092-52-4
000092-87-5
PENTACHLOROPHENOL
TRICHLOROPHENOL, 2,4,6-
NITROTOLUENE, 0-
CHLORONITROBENZENE, 0-
NITROANILINE, 2-
DINOSEB
PHTHALIC ACID, 0-
PHENYLPHENOL, 2-
NAPHTHALENE
QUINCLINE
DIETHYLANRINE, N,N-
DICHLOR08ENZIDINE, 3,3'-
BIPHENYL, 1,1'
BENZIDINE
000093-65-2
METHYL-4-CHLOROPHENOXY) PROPIONIC ACID, 2-(2-
000093-71-0 ALLIDOCHLOR
000093-72-1
TRICHLOROPHENOXY) PROPIONIC ACID, 2(2,4,5-
000093-76-5
TRICHLOROPHENOXY ACETIC ACID, 2,4,5-
000094-74-6
METHYL-4-CHLOROPHENOXY ACETIC ACID, 2-
000094-75-7 DICHLOROPHENOXY ACETIC ACID, 2,4-
000094-81-5
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2-
000094-82-6 2,4-DB
000094-82-6
DICHLOROPHENOXY) BUTYRIC ACID, 4-(2,4-
000095-47-6 XYLENE, 0-
000095-48-7 CRESOL, 0-
000095-48-7 2-METHYLPHENOL
000095-49-8 CHLOROTOLUENE, 0-
000095-50-1 DICHLOROBENZENE, 1,2-
000095-51-2 CHLOROANILINE, 2-
000095-53-4 METHYLANIL1NE, 2-
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER) continued
July 1997
>
(Jl
000095-54-5 PHENYLENEDIAMINE, 0-
000095-55-6 AMINOPHENOL, 0-
000095-57-8 CHLOROPHENOL, 2-
000095-65-8 DIMETHYLPHENOL, 3,4-
000095-68-1 DIMETHYLANILINE, 2,4-
000095-69-2 CHLORO-2-METHYLANILINE, 4-
000095-70-5 TOLUENE-2,5-D!AHINE
000095-77-2 01CHLOROPHENOL, 3,4-
000095-80-7 TOLUENE-2,4-DIAMINE
000095-87-4 DIMETHYLPHENOL, 2,5-
000095-94-3 TETRACHLOROBENZENE, 1,2,4,5-
000095-95-4 TRICHLOROPHENOL, 2,4,5-
000096-12-8 DIBROMO-3-CHLOROPROPANE, 1,2
000096-18-4 TRICHLOROPROPANE, 1,2,3-
000096-19-5 TRICHLOROPROPENE, 1,2,3-
000096-33-3 METHYL ACRYLATE
000096-45-7 ETHYLENE THIOUREA
000096-48-0 BUTYROLACTONE, GAMMA-
000097-63-2 ETHYL METHACRYLATE
000098-01-1 FURFURAL
000098-07-7 BENZOTRICHLORIDE
000098-56-6 CHLOROBENZOTRIFLUORIDE, 4-
000098-82-8 CUMENE
000098-83-9 METHYL STYRENE, ALPHA
000098-86-2 ACETOPHENONE
000098-87-3 8ENZAL CHLORIDE
000098-95-3 NITROBENZENE
000099-08-1 NITROTOLUENE, M-
000099-09-2 NITROANILINE, M-
000099-35-4 TRINITROBENZENE, 1,3,5-
000099-55-8 METHYL-5-NITROAN1LINE, 2-
000099-59-2 METHOXY-5-NITROANILINE, 2-
000099-65-0 DINITROBENZENE, 1,3-
000099-99-0 NITROTOLUENE, P-
000100-00-5 CHLORONITROBENZENE, P-
000100-01-6 NITROANILINE, P-
000100-21-0 PHTHALIC ACID, P-
000100-21-0 TEREPHTHALIC ACID
000100-25-4 DINITROBENZENE, 1,4-
000100-40-3 VINYL-1-CYCLOHEXENE, 4-
000100-41-4 ETHYL BENZENE
000100-42-5 STYRENE
000100-44-7 BENZYL CHLORIDE
000100-51-6 BENZYL ALCOHOL
000100-52-7 BENZALDEHYDE
000100-54-9 NICOTINONITRILE
000101-14-4
METHYLENE-BIS(2-CHLOROANILINE), 4,4'-
000101-55-3 BROMOPHENYL PHENYL ETHER, 4-
000101-61-1
METHYLENE-BIS(N,N'-DIMETHYL)ANILINE, 4,4'-
000101-68-8 DIPHENYLMETHANE DIISOCYANATE
000101-68-8
METHYLENEDIPHENYL ISOCYANATE, 4,4-
000101-77-9 METHYLENE-BIS(BENZENEAMINE), 4,4-
000103-33-3 AZOBENZENE
000103-69-5 ETHYLANILINE, N-
000105-60-2 CAPROLACTAM
000105-67-9 DIMETHYLPHENOL, 2,4-
000106-13-8 ETHOXYETHANOL DODECANOATE, 2-
000106-37-6 DIBROMOBENZENE, 1,4-
000106-42-3 XYLENE, P-
000106-43-4 CHLOROTOLUENE, P-
000106-44-5 4-METHYLPHENOL
000106-44-5 CRESOL, P-
000106-46-7 DICHLOROBENZENE, 1,4-
000106-47-8 CHLOROANILINE, 4-
000106-48-9 CHLOROPHENOL, 4-
000106-49-0 TOLUIDINE, P-
000106-50-3 PHENYLENEDIAMINE, P-
000106-74-1 ETHOXYETHANOL ACRYLATE, 2-
000106-89-8 EPICHLOROHYDRIN
000106-93-4 DIBROMOETHANE, 1,2-
000106-99-0 BUTADIENE, 1,3-
000107-02-8 ACROLEIN
000107-05-1 ALLYL CHLORIDE
000107-12-0 PROPIONITRILE
000107-13-1 ACRYLONITRILE
000107-15-3 ETHYLENE DIAMINE
000107-16-4 FORMALDEHYDE CYANOHYDRIN
000107-13-6 ALLYL ALCOHOL
000107-20-0 CHLOROACETALDEHYDE
000107-21-1 ETHYLENE GLYCOL
000107-30-2 CHLOROMETHYL METHYL ETHER
000107-98-2 PROPYLENE GLYCOL MONOMETHYL ETHER
000108-05-4 VINYL ACETATE
000108-10-1 METHYL ISOBUTYL KETONE
000108-31-6 MALEIC ANHYDRIDE
000108-38-3 XYLENE, M-
000108-39-4 3-METHYLPHENOL
000108-39-4 CRESOL, M-
000108-41-8 CHLOROTOLUENE, M-
000108-42-9 CHLOROANILINE, 3-
000108-43-0 CHLOROPHENOL, 3-
000108-44-1 TOLUIDINE, M-
000108-45-2 PHENYLENEDIAMINE, M-
000108-60-1 BIS(2-CHLORO-1-METHYLETHYL) ETHER
000108-87-2 METHYLCYCLOHEXANE
000103-83-3 TOLUENE
000108-90-7 CHLOROBENZENE
000108-91-8 CYCLOHEXYLAMINE
000108-93-0 CYCLOHEXANOL
000108-95-2 PHENOL
000108-98-5 THIOPHENOL
000108-98-5 BENZENETHIOL
000109-66-0 PENTANE, N-
000109-69-3 CHLOROBUTANE, 1-
000109-77-3 MALONONITRILE
000109-78-4 ETHYLENE CYANOHYDRIN
000109-86-4 METHOXYETHANOL, 2-
000110-00-9 FURAN
000110-49-6 METHOXYETHANOL ACETATE, 2-
000110-54-3 HEXANE, N-
000110-61-2 SUCCINONITRILE
000110-80-5 ETHOXYETHANOL, 2-
000110-86-1 PYRIDINE
000111-15-9 ETHOXYETHANOL ACETATE, 2-
000111-44-4 BIS(2-CHLOROETHYL) ETHER
000111-69-3 ADIPONITRILE
000111-76-2 ETHYLENE GLYCOL MONOBUTYL ETHER
000111-90-0 DIETHYLENE GLYCOL MONOETHYL ETHER
000112-34-5 DIETHYLENE GLYCOL MONOBUTYL ETHER
000115-29-7 ENDOSULFAN
000116-06-3 ALDICARB
000117-81-7 BIS(2-ETHYLHEXYL) PHTHALATE
000117-81-7 DEHP
000117-84-0 DI-N-OCTYL PHTHALATE
000118-74-1 HEXACHLOROBENZENE
000118-75-2 CHLORANIL
000118-96-7 TRINITROTOLUENE, 2,4,6-
000119-90-4 DIMETHOXYBENZIDINE, 3,3'-
000119-93-7 DIMETHYLBENZIDINE, 3,3'-
000120-12-7 ANTHRACENE
000120-36-5 DICHLORPROP
000120-61-6 DIMETHYLTEREPHTHALATE
000120-82-1 TRICHLOROBENZENE, 1,2,4-
000120-83-2 DICHLOROPHENOL, 2,4-
000121-14-2 DINITROTOLUENE, 2,4
000121-69-7 DIMETHYLANILINE, N,N-
000121-73-3 CHLORONITROBENZENE, M-
000121-75-5 MALATHION
000121-82-4 CYCLONITE
000121-82-4 RDX
000121-91-5 PHTHALIC ACID. M-
000122-34-9 SIMAZINE
000122-39-4 DIPHENYLAMINE, N,N-
000122-66-7 DIPHENYLHYDRAZINE, 1,2-
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER) Continued
July 1997
000123-30-8 AMINOPHENOL, P-
000123-31-9 HYDROQUINONE
000123-33-1 MALEIC HYDRAZIDE
000123-63-7 PARALDEHYDE
000123-73-9 CROTONALDEHYDE
000123-91-1 DIOXANE, 1,4-
000124-09-4 HEXAMETHYIENE DIAMINE
000124-48-1 DIBROMOCHLOROMETHANE
000126-98-7 METHACRYLONITRILE
000126-99-8 CHLORO-1.3-BUTADIENE, 2-
000126-99-8 CHLOROPRENE
000127-18-4 TETRACHLOROETHYLENE
000129-00-0 PYRENE
000130-15-4 NAPHTHOQUINONE, 1,4-
000131-11-3 DIMETHYLPHTHALATE
000132-64-9 DIBENZOFURAN
000133-06-2 CAPTAN
000133-07-3 FOLPET
000137-26-8 THIRAM
000139-40-2 PROPAZINE
000140-57-8 ARAMITE
000140-88-5 ETHYL ACRYLATE
000141-78-6 ETHYL ACETATE
000142-28-9 DICHLOROPROPANE, 1,3-
000142-82-5 HEPTANE, N-
OOOH3-33-9 SODIUM CYANIDE
000145-73-3 ENDOTHALL
000148-18-5 SODIUM DIETHYLDITHIOCARBAMATE
000150-50-5 MERPHOS
000151-50-8 POTASSIUM CYANIDE
000152-16-9 OCTAMETHYLPYROPHOSPHORAMIDE
000156-10-5 NITROSODIPHENYLAMINE, P-
000156-59-2 DICHLOROETHYLENE, 1,2-C-
000156-60-5 DICHLOROETHYLENE, 1,2-T-
000193-39-5 INDENO[1,2,3-CD]PYRENE
000206-44-0 ' FLUORANTHENE
000207-08-9 BENZO [K]FLUORANTHENE
000208-96-8 ACENAPTHYLENE
000218-01-9 CHRYSENE
000298-00-0 METHYL PARATHION
000298-02-2 PHORATE
000298-04-4 DISULFOTON
000299-84-3 RONNEL
000302-01-2 HYDRAZINE
000304-61-0 ANTIMONY POTASSIUM TARTRATE
000309-00-2 ALDRIN
000311-45-5 D1ETHYL-P-NITROPHENYL PHOSPHATE
000319-84-6 HEXACHLOROCYCLOHEXANE, ALPHA-
000319-85-7 HEXACHLOROCYCLOHEXANE, BETA-
000319-86-8
000329-71-5
000330-55-2
000333-41-5
000460-19-5
000479-45-8
000496-72-0
000504-24-5
000506-61-6
000506-64-9
000506-68-3
000506-77-4
000507-20-0
000510-15-6
000512-56-1
000526-75-0
000528-29-0
000531-82-8
000532-28-5
000534-52-1
HEXACHLOROCYCLOHEXANE, DELTA-
DINITROPHENOL, 2,5-
LINURON
DIAZINON
CYANOGEN
TRINITROPHENYLMETHYLNITRAMIME
TOLUENEDIAMINE, 3,4-
AMINOPYRIDINE, 4-
POTASSIUM SILVER CYANIDE
SILVER CYANIDE
CYANOGEN BROMIDE
CHLORINE CYANIDE
BUTYLCHLORIDE, T-
CHLOROBENZILATE
TRIMETHYL PHOSPHATE
DIMETHYLPHENOL, 2,3-
DINITROBENZENE, 1,2-
FURIUM
BENZALDEHYDE CYANOHYDRIN
DINITRO-0-CRESOL, 4,6-
000540-59EX1CHLOROETHYLENE, 1,2-
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER) continued
July 1997
I
->4
001336-36-3 POLYCHLORINATED BIPHENYLS
001338-23-4 METHYL ETHYL KETONE PEROXIDE
001563-66-2 CARBOFURAN
001569-02-4 PROPYLENE GLYCOL MONOETHYL ETHER
001582-09-8 TRIFLURALIN
001600-37-9 PENTACHLOROPROPENE, 1,1,2,3,3,-
001615-80-1 DIETHYLHYDRAZINE, 1,2-
001689-84-5 001689-99-28ROMOXYNIL OCTANOATE
001746-01-6 TCDD, 2,3,7,8-
001861-32-1 DACTHAL
001861-40-1 BENEFIN
001897-45-6 CHLOROTHALONIL
001912-24-9 ATRAZINE
001918-00-9 DICAMBA
001918-16-7 PROPACHLOR
001929-77-7 VERNOLATE
001929-77-7 VERNAM
001937-37-7 DIRECT BLACK 38
002008-41-5 BUTYLATE
002014-83-7 TRICHLOROTOLUENE. ALPHA,2,6-
002077-46-5 TRICHLOROTOLUENE, 2,3,6-
002104-96-3 BROMOPHOS
002212-67-1 MOLINATE
002303-16-4 DIALLATE
002303-17-5 TRIALLATE
002370-63-0 ETHOXYETHYL METHACRYLATE, 2-
002385-85-5 MIREX
002425-06-1 CAPTAFOL
002429-74-5 NIAGARA BLUE 48
002491-38-5 BUSAN 90
002602-46-2 DIRECT BLUE 6
002610-05-1 DIRECT SKY BLUE 68
002687-25-4 TOLUENEDIAMINE, 2,3-
002834-92-6 AMINO-2-NAPHTHOL, 1-
002921-88-2 CHLORPYRIFOS
003165-93-3
CHLORO-2-METHYLANILINE HYOROCHLORIOE, 4-
003175-23-3 TRICHLOROPROPANE, 1,2,2-
003380-34-5
TRICHLORO-2'-HYDROXYDIPHENYLETHER, 2,2,4'-
003383-96-8
003689-24-5
004399-55-7
004549-40-0
004901-51-3
005216-25-1
TETRACHLOROTOLUENE, PARA, ALPHA, ALPHA, ALPHA-
005598-13-0 CHLORPYRIFOS METHYL
006108-10-7 HEXACHLOROCYCLOHEXANE, EPSILON-
TEMEPHOS
TETRAETHYL DITHIOPYROPHOSPHATE
DIRECT LIGHTFAST BLUE
NITROSOMETHYLVINYLAMINE, N
TETRACHLOROPHENOL, 2,3,4,5-
006533-73-9 THALLIUM (J) CARBONATE 012427
007429-90-5 ALUMINUM 012672-
007439-89-6 IRON 013071-
007439-92-1 LEAD 013194-
007439-96-5 MANGANESE 013196-
007439-97-6 MERCURY, ELEMENTAL 013718-
007439-98-7 MOLYBDENUM 014797-
007440-22-4 SILVER 015950-
007440-24-6 STRONTIUM, STABLE 015972-
007440-36-0 ANTIMONY, METALLIC 016065-
007440-38-2 ARSENIC, INORGANIC 016071-
007440-39-3 BARIUM 016752-
007440-41-7 BERYLLIUM 018540-
007440-42-8 BORON, ELEMENTAL 020816-
007440-43-9 CADMIUM 020859-
007440-50-8 COPPER 021087-
007440-62-2 VANADIUM 021232-
007440-66-6 ZINC (METALLIC) 021436-
007446-09-5 SULFUR DIOXIDE 021564-
007446-18-6 THALLIUM (I) SULFATE
007446-34-6 SELENIUM SULFIDE 021725-
007487-94-7 MERCURIC CHLORIDE 022967-
007637-07-2 BORON TRIFLUORIDE 023950-
007664-41-7 AMMONIA 025013-
007664-93-9 SULFURIC ACID 025329-
007723-14-0 PHOSPHORUS, WHITE 026399-
007782-41-4 FLUORINE / (SOLUBLE FLUORIDE) 030560-
007782-49-2 SELENIUM 031512-
007783-00-8 SELENIOUS ACID 032534-
007783-06-4 HYDROGEN SULFIDE 032536-
007789-89-1 TRICHLOROPROPANE, 1,1,1- 033663-
007791-12-0 THALLIUM (I) CHLORIDE
007803-51-2 PHOSPHINE 033820-
008001-35-2 TOXAPHENE
008001-58-9 CREOSOTE, COAL TAR
008007-45-2 COKE OVEN EMISSIONS
ooaoia-oi-7 MANCOZEB
010028-15-6 OZONE
010034-93-2 HYDRAZINE SULFATE
010102-43-9 NITRIC OXIDE
010102-44-0 NITROGEN DIOXIDE
010102-45-1 THALLIUM (I) NITRATE
010436-39-2 TETRACHLOROPROPENE, 1,1,2,3-
010595-95-6 NJTROSOMETHYLETHYLAMINE, N-
010599-90-3 MONOCHLORAMINE
011097-69-1 AROCLOR 1254
012035-72-2 NICKEL SUBSULFIDE
012039-52-0 THALLIUM SELENITE
012122-67-7 ZINEB
38-2 MANEB
29-6 AROCLOR 1248
79-9 TERBUFOS
48-4 ETHOPROP
18-4 THIOFANOX
26-8 SODIUM METAVANADATE
65-0 NITRITE
66-0 TRICHLOROPHENOL, 2,3,4-
60-8 ALACHLOR
83-1 CHROMIUM(III)
86-6 DIRECT BROWN 95
77-5 METHOMYL
29-9 CHROMIUM(VI)
12-0 OSMIUM TETROXIDE
73-8 ALUMINUM PHOSPHIDE
64-9 METRIBUZIN
47-3 TETRACHLOROAZOXYBEN2ENE
96-4 DIMETHYLANRINE HYDROCHLORIDE, 2,4-
17-0
THIOCYANOMETHYLTHIO)BENZOTHIA20LE,
46-2
92-6
58-5
15-4
35-5
36-0
19-1
74-0
81-9
52-0
50-2
TRICHLOROANILINE HYDROCHLORIDE, 2,4,6-
53-0 ISOPROPALIN
CYANAZINE
METHYL MERCURY
PRONAMIDE
METHYL STYRENE (MIXED ISOMERS)
PENTACHLOROCYCLOPENTADIENE
PROFLURALIN
ACEPHATE
BUSAN 77
PENTABROMODIPHENYL ETHER
OCTABROMODIPHENYL ETHER
-------
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER AND CHEMICAL NAME CROSS REFERENCE
(LISTED BY CHEMICAL ABSTRACTS REGISTRY NUMBER) Continued July 1997
036907-42-3 VANADIUM SULFATE
039638-32-9 BISC2-CHLOROISOPROPYL) ETHER
040487-42-1 PENDIMETHALIN
041851-50-7 CHLOROCYCLOPENTADIENE
051218-45-2 METOLACHLOR
059756-60-4 FLURIDONE
060238-56-4 CHLORTHIOPHOS
068554-00-7 ETHOXYETHANOL PHOSPHATE, 2-
071753-42-9 TETRACHLOROHYDRAZOBENZENE
077323-84-3 TRICHLOROCYCLOPENTADIENE
VARIOUS BROMINATED DIBENZOFURANS
NO CASRN BROMINATED DIBENZO-P-DIOXINS
NO CASRN BROMOCHLOROETHANES
NO CASRN OICHLOROBUTENES
NO CASRN LEAD ALKYLS
NO CASRN NICKEL, REFINERY DUST
VARIOUS NICKEL, SOLUBLE SALTS
NO CASRN NITROGEN OXIDES
NO CASRN N1TROPHENOLS
NO CASRN PARTICULATE MATTER
NO CASRN PHOTOCHEMICAL OXIOANTS
> NO CASRN POLYBROMINATED BIPHENYLS
i NO CASRN SULFUR OXIDES
00 NO CASRN THALLIUM, INSOLUBLE SALTS
NO CASRN TIN AND COMPOUNDS
NO CASRN TRIMETHYLBENZENES
NO CASRN TRINITROPHENOLS
-------
APPENDIX A-IV
A-19
-------
APPENDIX A-IV
IV. EFFECT LEVEL DEFINITIONS
Adverse effect. A biochemical change, functional impairment, or pathologic lesion that
either singly or in combination adversely affects the performance of the whole
organism, or reduces an organism's ability to respond to an additional environmental
challenge.
Frank-effect-level (FED. The expqsure level at which there are statistically or
biologically significant increases in frequency or severity of severe effects between the
exposed population and its appropriate control group. These severe effects produce an
unmistakable adverse health effect (such as severe convulsions or death).
Lowest-observed-adverse-effect level (LQAEL). The lowest exposure level at which
there are statistically or biologically significant increases in frequency or severity of
adverse effects between the exposed population and its appropriate control group.
Lowest-observed-effect level (LOED. The lowest exposure level at which there are
statistically or biologically significant increases in frequency or severity of any effects
between the exposed population and its appropriate control group. The effects that are
seen at this level may or may not be considered as adverse.
No-observed-adverse-effect level (NQAEL). An exposure level at which there are no
statistically or biologically significant increases in the frequency or severity of adverse
effects between the exposed population and its appropriate control; some effects may
be produced at this level, but they are not considered to be adverse.
No-observed-effect level (NOEL). An exposure level at which there are no statistically
or biologically significant increases in the frequency or severity of any effect between
the exposed population and its appropriate control.
Adapted from: U.S. EPA. 1991. Integrated Risk Information System (IRIS). Online.
National Center for Environmental Assessment, Cincinnati, OH.
A-20
-------
APPENDIX A-V
A-21
-------
APPENDIX A-V
V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
The Clean Air Act requires that National Ambient Air Quality Standards (NAAQS)
be set and ultimately met for any air pollutant which, if present in air, may reasonably be
anticipated to endanger public health or welfare and whose presence in the air results
from numerous or diverse mobile and/or stationary sources. Since the primary NAAQS
and the inhalation RfC serve essentially the same function, and the primary NAAQS
have extensive data bases rigorously reviewed, the primary NAAQS with annual
averaging times should be used in lieu of an inhalation RfC, except for lead. In deriving
a risk assessment number for lead (Pb), the Integrated Exposure Uptake Biokinetics
(IEUBK) model should be used instead of the RfC. Primary standards are designed to
protect public health and secondary standards are designed to protect public welfare.
Each primary NAAQS has either one or two averaging times depending on the health
effects of the chemical. To date, six NAAQS have been established: Carbon Monoxide
(CO), Lead (Pb), Nitrogen Dioxide (NO2), Particulate Matter, less than 10 um in size,
(PM10), Ozone (03) and Sulfur Dioxide (SO2). A table of the most recent NAAQS is
provided as Table A-V-1.
The process of establishing and revising the NAAQS is detailed by Padgett and
Richmond (Journal of the Air Pollution Control Association, 33:13-16, 1983). The
primary NAAQS are solely health based and designed to protect the most sensitive
group of individuals (but not necessarily the most sensitive members of that group)
against adverse health effects. Thus, by definition, the NAAQS primary standards
define allowable pollutant concentrations which can be present in the atmosphere
without causing adverse effects, and essentially serve the same function as an
inhalation RfC in a risk assessment/risk management decision, except for lead. The
data bases supporting each of the NAAQS are extensive. More importantly, the
NAAQS are set by the USEPA Administrator as mandated by Congress after numerous
reviews and a public comment process.
A-22
-------
TABLE A-V-1
NATIONAL AMBIENT AIR QUALITY STANDARDS3
(as of December 2, 1991)
Pollutant
Carbon monoxide (CO)
Lead (Pb)
(and Lead compounds
Nitrogen dioxide (NO2)
(Nitrogen oxide)
(Nitric oxide)
Particulate Matter
(PM10)
Ozone (03)
Sulfur dioxide (SO2)
(Sulfur oxide)
Primary Standards'5
9 ppm (10 mg/m3)
35 ppm (40 mg/m3)
1.5 ug/m3
0.053 ppm
(100 |jg/m3)
50 ug/m3
1 50 Mg/m3
0.12 ppm
(235 M9/m3)
0.03 ppm
(80 Mg/m3)
0.14 ppm
(365 M9/m3)
Averaging
Time
8 hour0
1 hour0
Quarterly
Annual
Annuald
24 hours6
1 hourf
Annual
24 hours'
3 hours0
Secondary
Standards"
None
Same as primary
Same as primary
Same as primary
Same as primary
0.5 ppm
(1300 Mg/m3)
aSource: U.S. EPA 1991. Subchapter C - Air Programs. Part 50 -National Primary and
Secondary Ambient Air Quality Standards. Code of Federal Regulations 50: 693-697.
Revised 7/1/91.
"Primary standards are designed to protect public health; Secondary standards are designed to
protect public welfare.
cNot to be exceeded more than once per year.
"The standard is attained when the expected annual arithmetic mean concentration is less than
or equal to 50 M9/m3.
eThe standard is attained when the expected number of days per calendar year with a 24-hour
average concentration above 150 M9/m3 is equal to or less than 1.
'The standard is attained when the expected number of days per calendar year with maximum
hourly average concentrations above 0.12 ppm is equal to or less than 1.
A-23
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