UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                                WASHINGTON, D.C. 20460
                                      June 3, 1998

EPA-SAB-EC-CON-98-002 **/
                                                                      OFFICE OF THE ADMINISTRATOR
TT     ui  ^   ix* r,                                                   SCIENCE ADVISORY BOARD
Honorable Carol M. Browner
Administrator
U.S. Environmental Protection Agency
401 M Street, SW
Washington, DC  20460

             Subject:       Notification of a Consultation on Screening and Testing of
                           Endocrine Disrupters.

Dear Ms. Browner:

       A joint panel of the Science Advisory Board (SAB) and the FIFRA Scientific Advisory
Panel (SAP) met on May 5 and 6, 1998,  to consult with the Office of Prevention, Pesticides, and
Toxic Substances (OPPTS) and the Office of Water (OW) on issues concerning the screening and
testing of substances for endocrine disrupter activity.  The SAB has developed the consultation as  ' '
a mechanism to advise the Agency on technical issues that should be considered in the
development of regulations, guidelines, or technical guidance before the Agency has taken a
position.  A consultation is conducted under the normal requirements of the Federal Advisory
Committee Act, which include advance notice of the public meeting in the Federal Register.

       As is our customary practice, there will be no formal report as a result of this consultation,
nor do we expect any formal response from the Agency  However, the joint SAB/SAP panel
looks forward to the opportunity of conducting a formal review of the proposed approaches for
screening and testing substances for endocrine disrupter activity in the future.

                                        Sincerely,

                                                   I   0"
                                                   fa.  feJo^a-ey

                                          r. Joan Daisey,  Chair
                                        Science Advisory Board
                                        Dr. Ernest E McConnell, Chair
                                        FIFRA Scientific Advisory Panel
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                        U. S. Environmental Protection Agency Science Advisory Board
                                                   and
                                      FIFRA Scientific Advisory Panel
                         Joint Endocrine Disrupter Screening and Testing Review Panel

           Chairs
_         Dr. Ernest McConnell (SAP), President, ToxPath, Inc. Raleigh, NC
cr^*-1
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           Dr. Joan Daisey, Indoor Environmental Program, Lawrence Berkeley Laboratory, Berkeley, CA
vr~.
9
•• "         Members
*;^         	
it         Dr. Richard Bull, Battelle Pacific Northwest Laboratories, Richland, WA
-i\.
v_(         Dr. Charles C. Capen, Department of Veterinary Biology, The Ohio State University,
CJ         Columbus, OH

           Dr. Robert Chapin, National Institute of Environmental Health Sciences, Research Triangle
           Park, NC

           Dr. Kenneth Davis, Ecological research Center, Department of Biology, University of
           Memphis, Memphis, TN

           Dr. John Doull,  Department of Pharmacology, Toxicology and Therapeutics, The University of
           Kansas Medical Center, Kansas City, KS

           Dr. Paul M.D. Foster, Chemical Industry Institute of Toxicology, Research Triangle Park, NC

           Dr. James Gibson, Dow AgroSciences, Indianapolis IN

           Dr. Tim Gross, Endocrinology Research Program, Florida Caribbean Science Center, Biological
           Resources Division, U.S. Geological Survey, U.S. Department of the Interior, Gainesville, FL

           Dr. James Hanson, Department of Pediatrics, University of Iowa, Iowa City, IA

           Dr. Diane Henshel, School of Public and Environmental Affairs,  Indiana University,
           Bloomington, IN

           Dr. Alan Maki, Exxon Company, Houston, TX

           Dr. Genevieve M. Matanoski, School of Hygiene and  Public Health, Johns Hopkins University,
           Baltimore, MD

           Dr.. Margaret  McCarthy, Department of Physiology, School of Medicine, University of
           Maryland at Baltimore, Baltimore, MD

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Dr. Michael McClain, Consultant in Toxicology, Randolph NJ

Dr. P.M. Anne McNabb, Department of Biology, Virginia Polytech Institute and State
University, Blacksburg, VA

Dr. Geoff Scott, Charleston Laboratory, NOAA/NMFS, Charleston, SC

Dr. Mary Anne Thrall, Department of Pathology, College of Veterinary Medicine,  &
Biomedical Sciences, Colorado State University, Fort Collins, Colorado

Dr. John G. Vandenbergh, Department of Zoology, College of Agriculture and Life Sciences,
North Carolina State University, Raleigh, NC

Dr. Tim Zacharewski, Department of Biochemistry, Michigan State University, East Lansing,
MI

Staff
Mrs. Anne Barton, Designated Federal Official, Science Advisory Board, U.S. Environmental
Protection Agency, Washington, D.C.

Mr. Larry Dorsey, Designated Federal Official, FIFRA Scientific Advisory Panel, U.S.
Environmental Protection Agency, Washington, D.C.

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                                   NOTICE

      This report has been written as part of the activities of the Science Advisory
Board, a public advisory group providing extramural scientific information and advice to
the Administrator and other officials of the Environmental Protection Agency. The
Board is structured to provide balanced, expert assessment of scientific matters related
to problems facing the Agency. This report has not been reviewed for approval by the
Agency and, hence, the contents of this report do not necessarily represent the views
and policies of the Environmental Protection Agency, nor of other agencies in the
Executive Branch of the Federal government, nor does mention of trade names or
commercial products constitute a recommendation for use.

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U.S. Environmental Protection Agency
Region 5, Library (PL-12J)
77 West Jackson Bgulevard, 12th FtoOT
Chicago, It  60604-3590

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