600R80101
                         GUIDELINES AND SPECIFICATIONS
                                     FOR
                   PREPARING  QUALITY ASSURANCE PROGRAM  PLANS
                                 QAMS-004/80
                                                                              t
                       Quality Assurance Management Staff
               Office of Monitoring Systems and Quality Assurance
                       Office of Research and Development
                 United States Environmental Protection Agency
                        US. EnvlnonmtntaJ Protection
                        Region v, Library
                        230 South Dearborn Strett
                        Chrcag*. Illinois  60604
                              September 20, 1980

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Environmental

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                            TABLE OF CONTENTS


Subject                                                             Page

Introduction	•	    1

Scope	•	•	    1

Quality Assurance Program Plan Preparation and Responsibility  . .    2

Quality Assurance Program Plan Submission Procedures 	    2

Quality Assurance Program Plan Review and Approval 	    2

Quality Assurance Program Plan Content Requirements  	    3

     1.0  Identification of Office, Region, or Laboratory
          Submitting Quality Assurance Program Plan  	    3

     2.0  Introduction 	    3

     3.0  Quality Assurance Policy Statement 	    3

     4.0  Quality Assurance Management ..... 	    4

     5.0  Personnel Qualifications 	    6

     6.0  Facilities, Equipment, and Services  	    6

     7.0  Data Generation	    7

     8.0  Data Processing	    9

     9.0  Data Quality Assessment	   10

    10.0  Corrective Action	   10

    11.0  Implementation Requirements and Schedules  .......   11

Specific Guidance  	   13

Definition of Terms	   16

Appendices

A.  Administrator's Policy Statement of May 30,  1979

B.  Administrator's Memorandum of June 14,  1979
                                    i.

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                                              Guides lor ^
                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 1 of 18
                      GUIDELINES AND SPECIFICATIONS
                                   FOR
                PREPARING QUALITY ASSURANCE PROGRAM PLANS
INTRODUCTION

     Environmental Protection Agency  (EPA)  policy requires participation
by all EPA Regional Offices,  Program Offices, EPA Laboratories, and States
in a  centrally-managed Quality Assurance (QA)  program (see Appendix A—
Administrator's policy  statement  of  May  30,   1979)   and includes  all
monitoring and measurement  efforts  mandated or  supported  by EPA through
regulations, grants,  contracts,  or other formalized means not currently
covered by regulation  (see Appendix B—Administrator's memorandum of June
14, 1979).  The responsibility for developing, coordinating, and directing
the implementation  of this program has  been delegated to  the  Office of
Research and Development  (ORD) which established the  Quality Assurance
Management Staff (QAMS) for this purpose.

     In this document, we define "quality assurance" and "quality control"
as follows:

     Quality Assurance  -  the  total  integrated  program  for  assuring
                         reliability of  monitoring and measurement  data

     Quality Control   - the routine application of procedures for
                         obtaining prescribed  standards  of  performance
                         in the monitoring and measurement process.

Accordingly, the QA program plan is  a  document  to  be prepared  by  each
Program Office, Regional Office, and Laboratory which includes the overall
policies, organization objectives, and functional responsibilities design-
ed to achieve data quality  goals for  the activities  for which the parti-
cular organization is responsible.
SCOPE

     The Agency QA  program encompasses all  environmentally-related mea-
surement activities  supported  or  required  by  EPA.   "Environmentally-
related measurement activities" include all field and laboratory investi-
gations that generate data involving the measurement of chemical, physi-
cal, or biological  parameters in  the  environment;  determining  the pre-
sence or absence  of pollutants in  waste  streams; health  and ecological
effect studies; clinical and  epidemiological  investigations;  engineering
and process  evaluations;  studies  involving  laboratory  simulation  of
environmental events; and studies or measurements on pollution transport,
including diffusion models.

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                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 2 of 18
QUALITY ASSURANCE PROGRAM PLAN PREPARATION RESPONSIBILITY

     Each Program  Office,  Regional  Office,  National  Laboratory,  State,
or other organization  is responsible for the preparation and implementa-
tion of a  QA program plan to  cover all environmentally-related measure-
ment activities.   For  administrative  purposes,  these  plans   should  be
issued at  the Deputy Assistant Administrator (DAA),  Regional Administra-
tor (RA), National Laboratory  Director,  or  similar levels of responsibi-
lity within  States and  other organizations.   For example, one  overall QA
program plan would be  prepared for the  Office  of Monitoring Systems and
Quality Assurance  and  a specific QA program  plan  for  each of  its two
Environmental Monitoring Systems  Laboratories  and its one Environmental
Monitoring and  Support  Laboratory  (see,  for  example,  page  8  of the
implementation plan)  For States, each State agency  carrying out environ-
mentally-related measurements will prepare a QA program plan.
QUALITY ASSURANCE PROGRAM PLAN SUBMISSION PROCEDURES

     QA program  plans  should be  submitted  through  normal  channels  of
authority for review or approval(s) as shown in Figure 1.

     Completed EPA  QA program plans  must be  submitted  to the Director,
Quality Assurance Management Staff (RD-680), Office of Monitoring Systems
and Quality Assurance,  Office of Research and Development, U.S. Environ-
mental Protection Agency,  401 M Street,  S.W., Washington,  D.C.   20460.
States and other  organizations  will submit their QA program plans to the
appropriate Regional  Quality  Assurance Management  Officer (RQAMO).   Any
questions concerning the preparation  of QA program  plans  or requests for
technical assistance  should  be  directed  to  QAMS.   The  Director  of
QAMS can be reached on (FTS/202)  426-2387.   States and other organizations
shall direct questions to the appropriate RQAMO.
QUALITY ASSURANCE PRORGRAM PLAN REVIEW AND APPROVAL

     QA program plans for EPA organizations will be evaluated by QAMS and
either approved  or  returned with explanation and  target  date for resub-
mission, in  accordance  with  QAMS   Standard  Operation  Procedure  (SOP)
Number 1 of May 19,  1980 for the review and approval of QA program plans.
The QA program plans for State agencies  will  be reviewed and approved by
the appropriate EPA Region.

     Approval of the QA program  plans will be  based  on  completeness and
appropriateness in covering  the  elements described in Sections 1 through
11.  A basic requirement for each QA program plan is that either it is or
can be implemented and  that its  implementation can be measured relative
to program  objectives.   For the  States,  the  approval  and implementation
of the  State QA  program plan will  be  incorporated  into the  State-EPA
Agreement.

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                                                     IGIT ^A £ A.u
                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 3 of 18
QUALITY ASSURANCE PROGRAM PLAN CONTENT REQUIREMENTS

     Sections 1 through 11 below describe the essential elements required
in any QA program plan and indicate format to be used.   All eleven elements
listed must  be  considered and  addressed.   Where an item is  not relevant,
a brief explanation  of why  it  is  not relevant must be included.  Section
12 provides  a  list   of  reference  documents that  may  be   used  in the
preparation  of these  plans.

           1.0  Identification of Office, Region, or Laboratory
                Submitting Quality Assurance Program Plans

     Each QA program  plan must have a cover sheet (shown on pp. 5 and 5a)
listing the  following information:

     o Document Title

     o Document  Control  Number  (assigned  by  the   submitting  office)

     o Unit's Full Name and Address

     o Name, Address  (if  different  from above), and  Telephone Number of
       the Individual Responsible for the Unit

     o QA Officer

     o Plan  Coverage shall identify  all major  organization units which
       are required to participate in the QA program

     o Concurrences  must include  the  QA  Officer   for  the  respective
       organization

     o Approval will  be  by  the RA or DAA or Laboratory Director, and the
       Director of QAMS

                            2.0  Introduction

     In this section,  a  brief background,  purpose,  and scope  of  the QA
program plan is set  forth.  This  section must  state the rationale for QA
application to  monitoring  and measurement  activities  and  establish  a
basis for integrating the mandatory  QA initiative into the  program plan.

                 3.0  Quality Assurance Policy Statement

     This policy  statement  provides  the  framework within  which  a  unit
develops and implements  its QA program.   The  policy  statement  must de-
scribe the  unit's  goals  and  specify  those  requirements and activities
needed to realize these goals.   Paralleling the Administrator's directive
of May 30,  1979,  the  unit's  policy statement must emphasize those require-
ments and activities needed to ensure that  all data obtained are of known

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                                              Guides for QA PROGRAM PLANS
                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 4 of 18
quality.  Policy  is  to be directed  towards  a formal  commitment  of time
and resources necessary  to  ensure that data  are  as  precise and accurate
and as complete and representative as required.

     The policy statement indicates management's commitment  to QA through-
out the  data  generating  and processing  operations.   All  reported data
must be  accompanied  by a  calculation of precision and  accuracy.   Where
appropriate, a  statement  on the  completeness,   representativeness,  and
comparability is to be included.

                    4.0  Quality Assurance Management

4.1  Introduction

     This section  must  present  the  QA  management  structure  of  the
     organization and  its relationship  to  the  national  program.   This
     section of the  plan shows  the  interrelationships  between the func-
     tional units and  the subunits which generate or manage data.  Also,
     the relationship  between  the  national  program managers  and  the
     Regions is to be described.

4.2  Assignment of Responsibilities

     The office with overall QA responsibility for the organization must
     be identified.  The  success  of the  QA program  depends  on the  QA
     office being organizationally independent of data-generating groups.
     In EPA, this office  must report to at  least  a  division director in
     the Regions  and Program  Offices,  and   a  comparable  level  in  ORD
     Laboratories and  the National   Enforcement  Investigations  Center-
     Denver.  Quality  control  (QC)   responsibility  within the  various
     organizational subunits should be stated.

     The QA responsibilities  of national  program managers vs. those  of
     the EPA Regions must be described.   For example,  national  program
     managers will identify  the monitoring  and  measurements  which will
     require QA  coverage by Regions  or  ORD Laboratories,  along  with
     minimum specifications  and acceptance  criteria  for the  data  which
     are generated.   The  Regions  would be responsible  for  assuring that
     QA program and project  plans meet these requirements.   Both Program
     Offices and Regions will follow guidance provided by QAMS.

4.3  Communications

     The "organizational  type"  chart  should be  used  to  indicate  the
     internal and external flow of QA information and reports.  Examples
     of information and reports  are shown in Section 4.5.

     The flow of reports  and other  QA information must  be  addressed and
     should specify  the  following:   (1) the responsibility  of  the  QA
     office; (2) what  levels  of the unit  will receive  various  reports;
     (3) how often the reports  will  be issued; (4) who will review these
     reports;  and (5)  who  will  take  follow-up  action,  if  necessary.

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                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 5 of 18
            QUALITY ASSURANCE PROGRAM PLAN IDENTIFICATION FORM
Document Title
Document Control Number 	(Internal Use Only)

Organization Title 	

           Address
Responsible Official 	 Telephone

               Title 	

Quality Assurance Officer	 Telephone

           Address
                         (If Different From Organization)

Plan Coverage 	

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                                              Date:   9-20-80
                                              Revision Number 2
                                              Page 5£ of 18
Concurrences
(1)   Name
     Title 	(Quality Assurance Officer)
 Signature	 Date
(2)   Name
     Title 	(Responsible Official)
 Signature 	 Date
Approval for Agency

(1)   Name 	
     Title 	(Director. QAMS)
 Signature	 Date
Approval for Implementation

(1)   Name 	
     Title 	(RA, DAA, or National Laboratory Director)
 Signature 	 Date
Comments

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                                              Date:  9-20-80
                                              Revision Number  2
                                              Page 07of  18
 4.4   Document  Control
     QA reports and  other vital  information, plans, and  directives are  to
     be maintained  under a document  control  procedure  as  described  in
     Section  1.4.1   of   the  Quality Assurance Handbook  for Air Pollution
     Measurement Systems, Volume I  (EPA-600/9-76-005).   Distribution  lists
     of personnel  who need to receive  QA reports and information should
     be maintained as part  of the document control system.

4.5  QA Program Assessment

     This  section  must  describe how  an  organization  will  continually
     review its QA program's benefits and effectiveness.

     Each  organization is required  to conduct periodic assessments of its
     total QA program.   Based on these assessments,  a semiannual written
     status report of QA activities and progress will be  forwarded to the
     QAMS  or  RQAMO.   These  QA reports  will  include  such information as:

     1.  Status of or Changes to QA Program Plans

     2.  Status of QA Project Plans

     3.  Measures of Data Quality

     4.  Significant  QA Problems,  Accomplishments,   and Recommendations

     5.  Results of Performance Audits

     6.  Results of Systems Audits

     7.  Status of QA Requirements  for Contracts and Grants

     8.  Summary of QA Training

                      5.0  Personnel Qualifications

     Each  organization must assure that  all personnel  performing  tasks
and functions related to  data quality have  the needed education, training,
and experience.  This includes  laboratory technicians,  analysts,  mainte-
nance technicians,   supervisors,  principal investigators,  statisticians,
project officers,  and  QA staff.   Personnel qualifications and  training
needs should be identified.

                 6.0  Facilities, Equipment,  and Services
     In this  section,  the  unit's approach to the  selection,  evaluation,
and maintenance (both  routine  and  corrective) of  its  equipment,  facili-
ties, and services is to be described.

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                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 1 of 18
     The QA program plan should address  general  environmental aspects of
the facilities and equipment which might impact data quality (temperature,
humidity, lighting, dust levels, etc.)*  It  should  also consider mainte-
nance requirements for  general  utilities and housekeeping services (vol-
tage control,  reagent  purity,  supply of  air and  water,  refrigerators,
incubators, laboratory  hoods,   glove  boxes,  etc.).   In addition,  this
plan should  identify  the monitoring  and inspection procedures,  service
manuals, maintenance  procedures,   and  service  agreements  utilized  to
maintain performance standards  for  equipment,  Including essential ancil-
lary equipment.

                           7.0  Data Generation

     This section  of  the  QA program plan  must  describe  procedures to
assure the  generation  of  reliable  data  by  all  environmentally-related
measurement activities.   To assure that all data generated are scientifi-
cally valid, defensible, comparable, and of known precision and accuracy,
these plans  must  provide  for  the  use  of  QA  project  plans and  SOPs.

7.1  Quality Assurance Project Plans

     Each QA  program  plan  must  identify  the  types  of monitoring  and
     measurement activities for which detailed QA  project  plans  must be
     developed and followed.   QA project plans are to be written for each
     specific project  or each  continuing  operation  by the  responsible
     Program Office, Regional Office, Laboratory,  contractor, grantee, or
     other organization.  Project plans must  contain  the  following,  as
     applicable:

     o Title Page, with provision for approval signatures

     o Table of Contents

     o Project Description

     o Project Organization and Responsibilities

     o QA Objectives for Measurement Data, in terms of  precision,  accu-
       racy, completeness,  comparability, and representativeness

     o Sampling Procedures

     o Sample Custody

     o Calibration Procedures  and  References

     o Analytical  Procedures

     o Data Analysis,  Validation,  and Reporting

     o Internal QC Checks

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                                                      ror  ^A
                                              Date:   9-20-80
                                              Revision Number 2
                                              Page 9  of 18


 7.1   Quality Assurance Project Plans  (Continued)

      o Transporation

      o Safety

      o Data Handling Procedures

      o Service Contracts

      o Measurement  of  Precision,  Accuracy, Completeness, Representative-
       ness, and Comparability

      o Document Control

      QA project plans  must be prepared in document  control format, with
 provision for  revision,  as  needed, and  with a  record   of  the  official
 distribution.

 7.2   Standard Operating Procedures

      SOPs should  be developed and used to implement  routine QC require-
      ments for  all monitoring  programs,   repetitive  tests  and  measure-
      ments, and for inspection  and maintenance  of facilities, equipment,
      and services.

      The organization's QA office will assist in the  preparation, review,
      and approval of all SOPs.  These SOPs should be  prepared in document
      control format and a record kept of the official distribution.  Once
      prepared, these SOPs  need  only be included in the  QA project plans
      by reference.

                           8.  Data Processing

      QA program plans  summarize  how all aspects  of data  processing will
 be managed and separately evaluated in order to characterize and maintain
 the integrity and quality  of the  data.  Data  processing  includes collec-
 tion, validation, storage, transfer,  and  reduction.   Those offices oper-
ating Automated Data Processing and  computer  systems  for data processing
must  describe  their  systems' operations   and  documentation.   Specific
instructions should be addressed in QA project plans.

8.1  Collection

     The QA project plan  must address  both manually collected  data  and
     computerized data acquisition systems.   The internal  checks  that
     must be used to avoid errors in the  data collection process  should
     be identified.

8.2  Validation

     Data validation is defined as the process whereby data  are  accepted

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                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 10 of 18
     or rejected based  on a  set  of criteria.  This aspect of QA involves
     establishing specified criteria for data validation.  The QA project
     plan must indicate the specified criteria that will be used for data
     validation.
8.3  Storage
     At every stage of data processing at which a permanent collection of
     data is  stored,  procedures  must  be  established  to  ensure  data
     integrity and security.  QA project plans must indicate  how specific
     types of  data  will  be  stored  with  respect  to  media,  conditions,
     location, retention time, and access.

8.4  Transfer

     QA project  plans will  describe procedures  which  must  be  used  to
     ensure that data transfer is error-free (or have an admlssable error
     rate), that no  information is  lost in  the  transfer, and  that the
     input is  completely  recoverable from the  output.   Examples of data
     transfer are:   copying raw data from a notebook onto a data form for
     keypunching, converting  a written  data  set  to  punched  cards,  or
     copying from computer tape to disk.   A QA project plan must indicate
     a minimum  number of  data  transfer steps  in the  data  processing.

8.5  Reduction

     Data reduction Includes  all  processes which  change either the form
     of expression or quantity of  data values or  numbers  of  data items.
     This category includes validation, verification, and statistical and
     mathematical analysis.  It is distinct from data transfer in that it
     entails a reduction  in the size or dimensionality  of  the  data set.

     Validation of the  data reduction process  itself must be  addressed
     (i.e., software  validation)  appropriate to  that  level of  effort
     involved.  Common to each  type  of processing  is  the capability of a
     reviewer to reliably  check the validity of  this conversion process
     against some prescribed methodology.

                       9.0  Data Quality Assessment

     QA program plans must describe how all data generated will be assessed
for accuracy, precision, completeness, representativeness, and comparabi-
lity.  The QA program must require that data be accompanied by a calcula-
tion of precision and accuracy.  Where  appropriate,  a  statement  on the
completeness, representativeness, and  comparability  also  should  be in-
cluded.

                         10.0  Corrective Action

     Each QA program  plan will  include  provisions for  establishing and
maintaining QA reporting  or  feedback channels to  the  appropriate manage-
ment authority to ensure  that  early and effective corrective action can
be taken when data quality  falls below required limits.   The QA program

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                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 11 of 18
plans also must include provisions to keep responsible management informed
of the performance  of  all data collection  systems  and  will describe the
mechanlsm(s) to be used when corrective  actions  are  necessary.  Corrective
action relates  to  the  overall QA management  scheme:   who is responsible
for taking  corrective  actions;  when are  corrective actions  to be taken;
and who  follows-up to  see  that corrective  actions have  been  taken and
that they have produced the desired results.

     Corrective actions  will be  minimized  through the  development and
implementation of  internal  controls prior  to an adverse program impact.
Each measurement  system must  have  limits  to  establish  when corrective
action must be taken.   A procedure must be established for each measurement
system to  show what corrective action will be  followed when established
limits for  this procedure  have  been  exceeded.   The  level within the
organization that  is  responsible  for taking  corrective action must be
specified.

     Results from  the  following QA activities may  initiate  a corrective
action:

     A.  Performance Audits

     B.  Systems Audits

     C.  Interlaboratory/Interfield Comparison Studies

     D.  Failure  to Adhere to  a QA Program  or Project Plan or  to   SOPs

              11.0  Implementation Requirements and Schedule

     The QA program plan  must  be accompanied by  an implementation  sche-
dule.  An  example  of  the QAMS  implementation  schedule is  shown  in the
Table on page 12.

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                                                      O £"
                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 12 of 18
                 IMPLEMENTATION REQUIREMENTS AND SCHEDULE
Requirement
By Whom
       Date
Agency QA Policy-General

Agency QA Policy-Contracts
 and Grants

Strategy for Developing
 Mandatory QA Program

Guidelines and Specifications
 for Preparing QA Program Plans

Guidelines for Implementing
 QA Requirements for Grants

Guidelines for Implementing
 QA Requirements for Contracts

Designation of QA Officers*

Model QA Program Plans (Ambient
 Air, Water, Region, (Laboratory)

Quality Assurance Clearinghouse

Guidelines for Preparing QA
 Project Plans

Draft QA Program Plans Submitted

Agency QA Report

QA Programs/Plans Approved

QA Cost Study Report

QA Workshops (QAOs, Project
 Officers,  Grants Administra-
 tors)

QA Project  Plans
Administrator

Administrator


ORD/Work Group


OMSQA/QAMS


OMSQA/QAMS
     \

OMSQA/QAMS


RAs, DAAs, Labs

ORD POs, ROs


OMSQA/QAMS

ORD POs, ROs


POs, ROs, Labs

OMSQA/QAMS

OMSQA/QAMS

ROs, ORD Labs

OMSQA/QAMS



POs, ROs, Labs
       5-30-80

       6-14-80


       2-13-80


       9-20-80


       2-22-80


       2-22-80


        3-1-80

       3-24-80


        5-1-80

       6-30-80


        6-6-80

        6-2-80

       9-15-80

       9-15-80

 To Be Planned
       10-1-80
and Continuing
*Regions and ORD have already designated QA Officers.

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                                              Date:   9-20-80
                                              Revision Number 2
                                              Page 13 of 18
SPECIFIC GUIDANCE

     Technical details and other information of QA and QC can be obtained
from the documents listed below:
     EPA-600/9-76-005
     EPA-600/4-77-027a
     EPA-600/4-77-027b
     Federal Register
     Volume 44,  27604
     EPA-600/4-79-019
     EPA-600/4-78-017
     EPA-600/4-75-008
     NTIS-PB-253258/AS
Quality Assurance Handbook for Air Pollution
Measurement Systems, Volume I—Principles
March 1976

Quality Assurance Handbook for Air Pollution
Measurement Systems, Volume II-Ambient Air
Specific Methods (especially Section 2.0.9)
May 1977

Quality Assurance Handbook for Air Pollution
Measurement Systems, Volume III—Stationary
Source Specific Methods
August 1977

Traceability Protocol for Establishing True
Concentrations of Gases Used for Calibration
and Audits of Air Pollution Analyzers
Protocol Number 2, June 1978

Transfer Standards for Calibration of Ambient
Air Monitoring Analyzers for Ozone
June 1978

List of Reference and Equivalent Methods

Criteria, Procedures, and Forms for the
Evaluation of Ambient Air Monitoring
Programs—Laboratory and Field
June 1979

Ambient Air Quality Monitoring, Data Reporting,
and Surveillance Provisions
May 10, 1979

Handbook for Analytical Quality Control in
Water and Wastewater Laboratories
March 1979

Procedures for the Evaluation of Environmental
Monitoring Laboratories
March 1978

Interim Radiochemistry Methodology for Drinking
Water

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                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 14 of 18
     EPA-600/8-78-008
     EPA-600/8-78-017


     EPA-600/4-79-202


     EPA-670/4-73-001



     EPA-600/7-77-088



     EPA-600/4-77-144
     EPA-600/4-78-033
     NTIS-PB-286981/AS

     EPA-600/4-78-032
     NTIS-PB-284850/AS
     EPA-600/1-79-008
     Environmental Toxicology
     Division, Health Effects
     Research Laboratory,
     U.S. EPA, Research
     Triangle Park, NC
Manual for the Interim Certification of Laboratories
Involved in Analyzing Public Drinking Water Supplies,
Criteria, and Procedures
August 1978

Microbiological Methods for Monitoring the Environment
December 1978

Methods for Chemical Analysis of Water and Wastes
March 1979

Biological Field and Laboratory Methods for Measuring
the Quality of Surface Water and Effluents
July 1973

Handbook for Analytical Quality Control in Radio-
Analytical Laboratories
August 1977

Quality Control for Environmental Measurements Using
Gamma-Radiospectrometry
December 1977

Radioactivity Standards Distribution Program. 1978-1979
June 1978

Environmental Radioactivity Laboratory Intercomparison
Studies Program 1978-1979
June 1978)

Manual of Analytical Quality Control for Pesticides and
Related Compounds in Human and Environmental Samples

Analysis of Pesticide Residues in Human and Environ-
mental Samples—A Compilation of Methods Selected for
Use in Pesticide Monitoring Programs
     Other guidance documents for the development and implementation of
the mandatory QA program are available from QAMS.  These include:
     QAMS-001/80
     QAMS-002/80
Strategy for the Implementation of the Environmental
Protection Agency's Mandatory Quality Assurance Program
March 11, 1980

Guidelines and Specifications for Implementing Quality
Assurance Requirements for EPA Contracts and Interagencj
Agreements Involving Environmental Measurements
May 19, 1980

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                                         Guides tor QA jPRUlirlArl
                                         Date:  9-20-80
                                         Revision Number 2
                                         Page 15 of 18
QAMS-003/80
QAMS-004/80
QAMS-005/80
Guidelines and Specifications for Implementing Quality
Assurance Requirements for EPA Grants and Cooperative
Agreements Involving Environmental Measurements
September 30, 1980

Guidelines and Specifications for Preparing Quality
Assurance Program Plans
September 20, 1980

Guidelines and Specifications for Preparing Quality
Assurance Project Plans
October 17, 1980

A Model Quality Assurance Program Plan for Regional
Offices
May 1980

A Model Quality Assurance Program Plan for the Office
of Air Quality Planning and Standards
May 1980

A Model Quality Assurance Program Plan for the Office
of Water Planning and Standards
May 1980

A Model Quality Assurance Program Plan for the Health
Effects Research Laboratory-Research Triangle Park,
North Carolina
May 1980

A Model Quality Assurance Program Plan for the
Environmental Research Laboratory-Narragansett
May 1980

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                                              Date:  9-20-80
                                              Revision Number 2
                                              Page 16 of 18
DEFINITION OF TERMS
     Definitions of key  terms used  in  this  guidance material  are given
     below:

     AUDIT - a systematic check  to determine  the quality  of  operation of
             some function  or activity*   Audits  may  be of  two  basic
             types:  (1)  performance audits   in  which  quantitative  or
             qualitative data are  independently obtained  for  comparison
             with routinely  obtained data in a measurement  systems,  or
             (2) systems audits  of  a qualitative nature  that  consist of
             an on-site review of a laboratory's quality assurance system
             and physical facilities for  sampling,  calibration,  and mea-
             surement.

     CONTRACT - the  legal instrument  reflecting a  relationship  between
             the Federal Government  and a State  or local government  or
             other recipient:  (1) whenever the principal purpose of the
             instrument is the acquisition, by purchase,  lease, or barter
             of property or services for the  direct benefit or use of the
             Federal Government;   or  (2)   whenever  an  executive  agency
             determines,  in a specific  instance,  that the use  of  a type
             of procurement contract is appropriate.

     COOPERATIVE AGREEMENT - the  legal instrument reflecting the relation-
             ship between the  Federal  Government  and a  State or local
             government or other recipient whenever:  (1)  the principal
             purpose of the  relationship  is  the transfer  of  money, pro-
             perty, services, or anything  of  value  to the  State or local
             government or other recipient to  accomplish a public purpose
             of support  or   stimulation authorized  by  Federal  statute,
             rather than acquisition, by  purchase,  lease,  or  barter  of
             property or services  for  the direct benefit  or use  of the
             Federal Government;  and (2) substantial involvement is anti-
             cipated between the  executive agency acting  for  the  Federal
             Government and  the   State  and   local  government  or  other
             recipient during performance  of  the contemplated  activity.

     DATA QUALITY - the totality of  features  and  characteristics  of data
             that bears on  its ability  to satisfy a given purpose.  The
             characteristics of major importance are accuracy,  precision,
             completeness,  representativeness, and  comparability.   These
             characteristics are  defined as follows:

             o accuracy - the degree  of  agreement of a measurement (or an
               average of measurements  of the  same thing),  X,  with  an
               accepted reference or true value, T, usually expressed  as
               the difference between the  two  values,  X-T,  or  the  differ-
               ence as a percentage  of  the reference or  true  value,  100
               (X-T)/T, and  sometimes expressed as  a ratio, X/T.   Accu-
               racy is a measure  of  the  bias in a system*

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                                         Date:  9-20-80
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        o precision - a measure of mutual agreement among individual
          measurements of the same property, usually under prescribed
          similar conditions*

          Precision is  most  desirably  expressed  in  terms  of the
          standard deviation.   Various measures of  precision  exist
          depending upon the  "prescribed similar conditions."

        o completeness  - a  measure  of the  amount  of  valid data
          obtained from a measurement system compared to the  amount
          that was  expected  to  be  obtained under  correct   normal
          corrections.

        o representativeness  -  the degree to which  data accurately
          and precisely represent  a  characteristic of a population,
          parameter variations at a sampling point, or an environmen-
          tal condition.

        o comparability - a measure of the confidence with which one
          data set can be compared to another.

DATA VALIDATION - a systematic effort to review data to identify any
        outliers or errors and thereby cause deletion or flagging of
        suspect values  to  assure  the  validity  of  the data  to the
        user.  This "screening" process may be done by manual  and/or
        computer methods, and it may  utilize any  consistent  tech-
        niques such as sample limits to screen out impossible  values
        or complicated  acceptable relationships  of  the data with
        other data.

ENVIRONMENTALLY-RELATED MEASUREMENTS  -  a  term  used  to  describe
        essentially all  field  and  laboratory  investigations that
        generate data involving  the  measurement of chemical,  physi-
        cal, or biological  parameters  in the environment; determin-
        ing the presence or  absence  of priority pollutants  in waste
        streams; health and  ecological  effect studies;  clinical and
        epidemiological investigations; engineering and process eval-
        uations; studies involving laboratory simulation of environ-
        mental events;  and   studies  or measurements  on  pollutant
        transport, including diffusion models.

GRANT - the legal instrument reflecting the relationship between the
        Federal Government and a State  or local government  or other
        recipient in which (1) the  principal purpose of the relation-
        ship is the transfer  of money, property,  services,  or any-
        thing of value  to the  State or  local  government  or other
        recipient in order to accomplish a public purpose of support
        of stimuation authorized  by  Federal  statute,  rather than
        acquisition,  by purchase,  lease,  or  barter,  or  property  or
        services for the direct  benefit or use of the Federal Govern-
        ment; and  (2)  no   substantial   involvement  is  anticipated
        between the executive agency, acting  for the Federal Govern-
        ment, and State  or local government or other recipient during
        performance of the contemplated activity.

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             Pre*ctton
South Dearborn

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                                         Revision Number 2
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GRANTEE - any individual, agency, or entity   jiich has been awarded a
        grant pursuant to grant regulations

PERFORMANCE AUDIT  -  planned  independent  check of the operation of a
        measurement  system to  obtain a  quantitative measure of  the
        quality of  the  data  generated.   This  involves the  use  of
        standard reference samples  or  materials which are certified
        as to their  chemical composition or physical characteristics

QUALITY ASSURANCE  - (1)  the total integrated  program  for  assuring
        the reliability of monitoring and measurement data

                     (2) a  system  for integrating  the quality plan-
        ning, quality  assessment,   and  quality  Improvement  efforts
        of various  groups in  an  organization  to  enable operations
        to meet user requirements at an economical level*  In pollu-
        tion measurement  systems,   quality assurance  is  concerned
        with all of  the activities  that  have  an important effect on
        the quality  of  the  pollution  measurements,  as  well as  the
        establishment of  methods  and  techniques   to  measure   the
        quality of  the  pollution measurements.   The  more authorita-
        tive usages  differentiate   between  "quality  assurance"   and
        "quality control," where  quality  control  is the  system of
        activities to provide  a "quality  product"  and quality assu-
        rance is  the  "system of  activities  to provide  assurance
        that the quality  control  system is  performing adequately"

QUALITY ASSURANCE  PROGRAM PLAN -  an orderly  assembly of management
        policies, objectives,  principles,  and general procedures by
        which an agency or  laboratory outlines  how it  intends  to
        produce quality data

QUALITY ASSURANCE PROJECT PLAN - an orderly assembly of detailed and
        specific procedures  by which an  agency or laboratory delin-
        eates how  it produces quality data  for a  specific  project
        or measurement method.  A  given  agency  or laboratory would
        have only  one  quality  assurance manual,  but would have a
        quality assurance plan for  each  of its projects or  programs
        (group of  projects using  the same measuremetn  methods;   for
        example, a laboratory  service group might  develop  a  plan by
        analytical instrument  since the  service is provided to a
        number of projects)

STANDARD OPERATING PROCEDURE  - an  operation,  analysis, or action
        whose mechanics are thoroughly prescribed and documented and
        which is commonly accepted  as the usual or normal method for
        performing certain routine  or repetitive tasks

QUALITY CONTROL - the routine application of procedures for obtaining
        prescribed standards   of  performance  in the   monitoring  and
        measurement process

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