PB87-112033
Pesticide Fact Sheet Number 1. DCNA
(U.S.) Environmental Protection Agency
Washington, DC
9 Jan 84
U.S. Environmental Protection Aftocy
Region 5, Library IPL-12J)
77 West Jackson Boulevard, 12th Floor
Chicago, IL 60604-3590
L
J
U.S.
Service
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REPORT DOCUMENTATION
PAGE
1. REPORT NO.
14. TKte and SubtKI*
,EPA Pesticide Fact Sheets -
No. 13
7. Author(s)
EPA, Office of Pesticide Programs, Registration Division
». Performing Organization Nam* and Address
US Environmental Protection Agency
Office of Pesticide Programs
Registration Division, TS-767C
401 M Street, S.W.
Washington, D.C. 20460
12. Sponsoring Organization Nam* and Address
Same as #9
PB07-1120J 1
B. Report Oat*
Issued 1/9/84
«. Performing Organization Rept No
540/FS-87- Q45
10. Proract/Tasfc/Work Unit No
11. CantracttQ or GranKG) No.
(C)
(G)
13. Typ* of Report A Period Covered
14.
IS. Supplementary Not**
16. Abstract (Umit: 200 word*)
This document contai.ns up-to-date chemical information, including a
summary of the Agency's regulatory position and rationale, on a specific
pesticide or group of pesticides. A Fact Sheet is issued after one of
the following actions has occurred.
1. Issuance or reissuance of a registration standard,
2. Issuance of each special review document,
3. Registration of a significantly changed use pattern,
4. Registration of a new chemical, or
An immediate need for information to resolve controversial
5.
issues relating to a specific chemical or use pattern.
17. Document Analyst* a. Detertptor*
Pesticides, regulations, Chemical Information Fact Sheet, Use Patterns,
Science Findings
b. Identlfi*r*/Op*n-End«d Terms
c. COSATI Reid/Group
Av.liability SUtemenl
Publicly Available
1*. Security Claw (Thl* Report)
Unclassified
murtty Clam» rthlf ^ra««)
classified
21. No. of Pag**
22. Price
(Set ANSI-Z39.18)
See Instruction* on rr*v*r»*
OPTIONAL FORM 272 (4-77)
(Fomwrty NTIS-35)
Department of Commerce
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United Stats* office of PwtickJw and Toxic Substances
Environmental Protection Office of Pesticide Programs (TS-766CI
Washington. DC 20460
&EPA Pesticide
Fact Sheet
Name of Chemical:
Reason for Issuance:
Date Issued:
Fact Sheet Number: ^°\3
1. Description of the Chemical:
Generic name: 2,6-dichloro-4-nitroaniline
Gorman name: dicloran
Trade name(s): DClft, botran, ditranil, allisan, and resisan
EPA Shaughnessy code: 031301
Chemical abstracts service (CAS) number: 99-30-9
Year of initial registration: 1961
Pesticide type: Funoicide
Chemical fanily: Nitroanaline
U.S. and foreign producer: Utriohn Company
2. Use patterns and formulations:
Application sites: DCNA is used to control a variety of
pre- and cost-harvest diseases on fruit and veoetable
croos. Current mator use sites include peaches, oraoes,
lettuce anr* celery. It is a orotectant to ornamentals and veget-
able seeds. It is also reaistere/* for use on cotton, a
number of ornamentals, a seed-piece die for sweet potatoes,
a oeanut see^ treatment, and in greenhouses on cucumbers,
lettuce, rhubarb, and tomatoes.
Tyues of formulations: Formulated products are 4, 5, 6,
8, 10, 12, 15, 20, 30, 35, or 50% dusts: 48.8 or 75*
wettable powders: 9 or 30% flowable concentrates: as 0.5
or 3% ready-to-use liouids: a 3% formulation in fruit
wax: and a 0.2% impregnated fruit wrap.
DCTv may be formulated with other pesticides such as
caotan, bencmyl, and parathion. It is not compatable with
some oil-based pesticides.
Types and Methods of application: DCN& nay be applied as
pre-harvest and post-harvest uses on fruit and vegetable
crops; seed and ornamental protectant. In the field,
DCNA can be applied by ground and aircraft. DCNA can be
applied as a post-harvest dip, spray, or dust to sane
fruits and vegetables and as a protectant to ornamental
crops orior to storage and shinment.
Application rates: 1.5 to 30 Ib/A.
Usual Carriers: either water or wax as diluent
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3. Science Finding?:
Summarv science statement: /
TTnere are extensive data cjaos for DOJk. No human toxicolooica". \^
hazards of concern, other thar inducement of skin photosensitivitv,
and possible ocular toxicity, have beer, identified in studies
reviewed by the Aoencv for this standard. Ihe Agency has no
information that indicates continued use will result in any
unreasonable adverse effects to nan or his environment during the
time required to deveioo the data.
Chemical characteristics:
DCJft is a vellow, crystalline powder. The solubilitv
of DOR in ethanol is 0.2% at 20°C and its melting point is
192-194°C. The chemical does not present any unusual handling
hazards.
Toxicology cnaracteristics:
Acute toxicology studies:
Acute Oral ID$Q in rats: >10,000 mg/kg, Toxicity category T\'
Acute Dermal L&JQ in rabbits: >2.0 q/kq, "Toxicity category m
Acute Inhalation ££55 in rats: >2 mq/1, Toxicitv catecrorv m
EXZNA does not induce skin or eve irritation - Itaxicity cateaorv Til
DCNfc was found to be a skin sensitizer and may induce phototoxicitv
due to the oresenc*? of aniline in its corcostior..
Chronic toxicology studies:
fftere is insufficient data to assess the subchronic dermal or
subchronic inhalation hazard
Chronic toxicitv in rats: NDEL = 100 pan: LEL = 3000 DOT
Oncoaenicitv study in rats: no tumors at 3000 par
Teratoaenicitv in rabbits: no abnormalities at 1000 DOT
Reoroduction in rats: ND^ = ion ppn
Mai or routes of exposure: Subchronic dermal or respiratory contact
Environmental characteristics:
Data are insufficient to fully assess the environmental
fate of DQft
Ecological characteristics:
Hazards to fish and wildlife:
Avian dietary ££50: Mallard duck - 9500 par,
Bobwhite quail - 2120 pprr
Pish I£50: >1.08 pprr.
Aquatic invertebrates LCso: 2.3 par,
Potential problems for endangered species: Hiil be reassessed
after review of environmental fate data.
Physiological and biochemical behavioral characteristics:
Mechanian of pesticidal action: Itxxjght to be a non-specific inhibitor
of cell division and can effect nuclear stability.
General metabolism in rats: 1.7 and 8 no/taj body weight was absorbed,
no body tissue accumulation was detected.
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Tolerance assessment:
List of crccc and tolerances dr. par.): annco'is fore and post Hi 2- ,
snapoeans 2C, blackDemes IE, bovsenoemes 15, carrots (post H 1"
celery 15, sweet cherries {ore and post H) 2C, cotton seeci C.I,
cucumoers 5, endive 30, garlic 5, arapes 10, kiwifruit (post Hi 2C,
lettuce 10, nectarines (ore and post H) 2C, onions 5, peaches
(pre and post H) 20, plums (fresh, orunes) (pre and post H) 15,
potatoes 0.25, raspberries 15, rhubaro 1C, sv^et potatoes (post
H) 10, tomatoes 5.
Tolerance reassessment: Due to the absence of oertinent data,
the Agency is unable to complete its reassessment of DCNA tolerances,
4. Summary of Regulatory Position and Rationale:
Use classification: general use
Unique label warnino statements: Manufacturino-use labels must
contain the statements "Do not discharge into lakes, streams,
ponds or public waters unless in accordance with NPDES permit.
Por guidance contact your regional office of EP^.P
5. Sunroary of Major Data Gaps:
Product chemistry: data due ~ ^8-
Identitv of ingredients
Statement of ccnoosition
Discussion on formation of contaminants
Preliminary analysis
Certification of 1 units
Analytical methods
Odor
Density, bulk density, or specific gravity
Solubility
Vapor pressure
Dissociation constant
Octanol/water partition coefficient
- Toxicology: studies due 1/88
Ocular toxicity
Photosensitization
21-day subchronic dermal
Oncogenicitv in mouse (in Drogress)
Tsratogenicity (in progress)
-Mutagenicity testing
Wildlife and Aquatic oraanisms: studies due 1/88
Single-dose oral ID^Q on one avian species
Acute 48 hour toxicitv study on a freshwater invertebrate
Fish embryo-larvae and/or aquatic field studies may
be required depending on environmental fate data
3
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Rnvironme-.tal Fate: studies dje 1/8?
Hydrolvsis stume?
Pnotcrieara.-iatior. stales ir water
Photodearedatior studies or soil
Aerobic soil metaboiisrr study
Anaerobic soil metabolism studv
Leachina and adsorption/desorntior. studies
Laboratorv volatility studies
Terrestrial field dissioation studies
LongtetJT: field dissipation studies
Confined accumulation studies on rotational crope
Laboratorv studies of pesticide accumulation in fish
Rentry Protection:
Data reouirement pending on results of toxicological testina
Residue Chemistry: studies due 1/88
Nature of residue for plants and animals
Residue analytical method for animals
Storage stability data
Crop field trials for potatoes, sweet potatoes, onions,
apricots, cherries, nectarines, reaches, Plums,black-
berries, boysenbetries, raspberries, kiwi
Processed food^eec for potatoes, tcroatoes, cottonseed
6. Contact persor. at F?'.
Mr. Henry K. Jacob-/
Environnental Protection Agency
FUnaicide-HerE'icide Branch (TS 76~-C:
401 K St., SW
Washinaton, D.C. 2046H
(703) 557-190C
DISQAIM15R: The information oresented in this Chemical Information
Fact She-t is for informational puposes only and may not be used to
fulfill' data requirements for pesticide registration and rereqistration.
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