United Satm Office of P«tksd«« •«! Toxic So*Mt»nc«
Emronmral Prot»ct.on O«.o» of P««t.od» PTOor»m» (TS-766C)
Ao«ncy Washington, DC 2O4«0
r/EPA Pesticide
Fact Sheet
Name of Chemical:
Reason for Issuance: New chemical
Date ISSUed: December 22, 1989
Fact Sheet Number: 210
1. Description of the Chemical
Generic Name: (alpha-Cyano-3-phenoxybenzyl-2,2,3,3-tetramethyl
cyclopropanecarboxylate)
Common Name: Fenpropathrin'(proposed)
Trade Name: Danitol
Other Names: S-3206, ML-41706, SD-41706
EPA Shaughnessy Code (OPP Chemical Code): 127901
Chemical Abstracts Service (CAS) Number: 39515-41-8
Year of Initial Registration: 1989
Pesticide Type: Insecticide-Miticide
Chemical Family: Pyrethroid
Producer: Sumitomo Chemical Company, Ltd.
2. Use Patterns and Formulations
Application Sites: -Greenhouse Ornamentals including Lath
House and Shade House Use (container-grown plants only).
Type and Methods of Application: Foliar spray (ground application)
Rates of Application: 0.1 to 0.3 pound active ingredient (ai) per
100 gallons of spray (5.33 to 16 oz product).
Types of Formulations: 90% Technical; 2.4 Emulsifiable Concentrate
Spray (30% ai; 2.4 Ib ai/gallon).
Usual Carriers: Water.
Target Pests: Mites (two spotted, Southern Red, European Red, McDaniel),
Aphids (apple, wooly apple, rose', Beet armyworm, mealybug (including
immature stages of citrus mealybug), potato leafhopper, San Jose
scale (crawlers, Japanese Beetle, spotted tentiform leafminer,
thrips, Pandemis moth, codling moth, leafrollers, southern red
pine, lacebugs.
Limitations: For Commercial Greenhouse Use Only.
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3. Science Findings
Summary Science Statement: The end-use product (Danitol 2.4 EC
Spray) has moderate to low acute oral, dermal, inhalation and eye/
skin irritation toxicity. This product is assigned to Toxicity
Category II (VJarning) due to oral route of exposure and eye irrita-
tion hazard. The technical product is highly toxic to mammals by
the oral route, with rat oral LD values of 54.0 mg/kg (male),
and 48.5 mg/kg (female). There was no evidence of any carcinogenic
effects in a 2-year dietary study (0, 40, 150, 600 ppm) in rats at
dose levels up to and including 600 ppm. No developmental toxic
effects were observed in rats at dose levels greater than 10 mg/kg/
day nor in rabbits at levels greater than 36 mg/kg/day (highest
dose levels tested). Fenpropathrin was not found to be mutagenic.
Laboratory data indicate fenpropathrin is extremely toxic to fish
and aquatic organisms and is toxic to wildlife. Leaching data show
that fenpropathrin and its aged residues are unlikely to leach in
most soils. It is unlikely that ground water contamination will
occur.
Chemical Characteristics: (Technical Grade)
Physical State: Liquid or solid
Color: Yellowish brown
Odor: Faint characteristic odor
Melting Pqint: 25-50 °C
Boiling Point: 377 °C
Specific Gravity: d 20/20 = 1.05
Density at 20 °C: 1.103
Empirical Formula: Co/iH9E.0->N
Molecular Weight: 349.4
Solubility: 0.33 ppm at 25 °C in HO; easily soluble in
common organic solvents
Octanol/Water Partition Coefficient: P = 1 X 10
ow
Storage Stability: Data indicate that S-3206 is stable
in organic solvents at warehouse temperature and in light
of wavelengths above 350 nm.
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Toxicology Characteristics
Technical Formulation;
o Acute Oral Toxicity, Rat: LDt-n = 54.0 mg/kg (males ), 48.5
mg/kg (females). Toxicity Category I
o Acute Dermal, Rat: LDcn = 1600 mg/kg (males), 870 mg/kg
(females). Toxicity Category II.
o Acute Inhalation LC , Mouse and Rat: The maximum attainable
concentration (0.009 ug/L as vapor) was nontoxic. Toxicity
Category IV.
Primary Eye Irritation, Rabbit: No corneal involvement. Mild iris
and conjunct!val irritant. Toxicity Category III.
Primary Dermal Irritation, Rabbit: Not an irritant. Toxicity Category
IV.
Dermal Sensitization, Guinea Pig: Not a sensitizer.
Neurotoxicity, Hen: No delayed neurotoxicity at <_ 1000 mg/kg/day x 5.
2-Year Feeding/Carcinogenic, Mouse: Systemic NOEL > 600 ppm (HOT; M/F
56.0/65.2 mg/kg/day). There were no indications of toxicity or
oncogenicity other than marginally increased hyperactivity in females
dosed at 600 ppm.
2-Year Feeding/Carcinogenic, Rat: Systemic NOEL = 450 ppm (17.06
mg/kg/day) in males, 150 ppm (7.23 mg/kg/day) in females
Systemic LEL = 600 ppm (HOT; 22.80 mg/kg/day) in males (increased
mortality, body tremors, increased pituitary, kidney, and adrenal
weights)
450 ppm (19.45 mg/kg/day) in females (increased mortality and body
tremors)
There was no evidence of oncogenicity at any dose.
1-Year Feeding, Dog: Systemic NOEL = 2.5 mg/kg/day
Systemic LEL = 6.25 mg/kg/day
Developmental Toxicity, Rabbit:
Maternal NOEL = 4 mg/kg/day
Maternal LEL = 12 mg/kg/day (grooming, anorexia, flicking
of the forepaws)
Developmental NOEL > 36 mg/kg/day (HOT)
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Developmental Toxicity, Rat:
Maternal NOEL = 0.4 mg/kg/day
Maternal LEL = 2.0 mg/kg/day
Developmental NOEL > 10 mg/kg/day (HOT)
3-Generation Reproduction, Rat:
Parents: Systemic NOEL = 40 ppm (M/F 3.0/3.4 mg/kg/day)
Systemic NOEL = 120 ppm (M/F 8.9/10.1 mg/kg/day)
(body tremors with spasmodic muscle twitches,
increased sensitivity and maternal lethality)
Pups: Reproductive NOEL = 120 ppm (M/F 8.0/10.1 mg/kg/day)
Reproductive LEL = 360 ppm (M/F 26.9/32.0 mg/kg/day)
(decreased mean F B pup weight, increased F B loss)
Fetotoxic NOEL = 40 ppm (M/F 3.0/3.4 mg/kg/day)
Fetotoxic LEL = 120 ppm (M/F 8.9/10.1 mg/kg/day) (body
tremors, increased mortality)
Mutagenicity Studies:
A. Gene Mutation Test:
Negative for Salmonella TA98, TA100,
TA1535, TA1537, and TA1538; and
jS. coli WP2uvrA (trp ) with or without
metabolic activation.
In Vitro Assay in
Mouse Lymphoma cells
Equivocal results - probably of no
concern
B. Structural Chromosome
Aberration Test:
Data submitted October 1989 and under
review.
C. In Vitro Sister Chromatid
Exchange Test:
There were no increases in sister
chromatid exchanges seen in CHO-K1
cells.
D. DNA Damaging Sister
Chromatid Exchange Test
Not mutagenic
Metabolism Studies:
A. Metabolism, Rat
(2 studies)
97% is eliminated in 48 hours.
Little residue after 8 days. Highest
concentration in fat. Metabolites
were identified in urine.
B. Percutaneous Absorption,
Rat
Over a 24-hour period, very little
test article was absorbed through the
skin. The major route of elimination
was the urine.
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End-Use Formulation:
o Acute Oral, Rat: LD = 72.4 mg/kg (males), 71.8 mg/kg
(females) and 72.1 mg/kg (both sexes). Toxicity Category
II
o Acute Dermal, Rabbit: LD > 2000 ma/kg. Toxicity Category
III
o Acute Inhalation, Rat: LC = 3.72 mg/L (males, 2.75 mg/L
(females), 3.20 mg/L (both sexes). Toxicity Category III
o Primary Eye Irritation, Rabbit: Moderately persistent corneal
opacity. Toxicity Category II
o Primary Dermal Irritation, Rabbit: Draize Score = 2.2. Toxicity
Category III
o Skin Sensitization, Guinea Pig: ttot a sensitizer
o 21-Day Dermal, Rabbits: Local irritation only at dose levels
of 100 mg/kg/day and above. No systemic pathology at 900
mg/kg (HOT)
Physiological and Biochemical Characteristics:
Foliar Absorption: Not absorbed
Translocation: Not translocated
Mechanism of Pesticide Action: Neurotoxicity characteristic of
pyrethroid insecticides (contact action).
Ecological Effects Characteristics:
Avian Acute Oral
Mallard Duck: LD = 1089 mg/kg
Avian Dietary
Bobwhite guail: LD = > 10,000
Mallard duck: LC ~= 9026 ppm
Freshwater Fish
Rainbow trout: LC = 2'^ ppb
Bluegill: LC =2.2 ppb
Channel catfish: LC =5.5 ppb
Sheepshead minnow: LC =3.1 ppb
Aquatic Invertebrate
Daphnia magna; LC = 0-53 ppb (48 hr)
Daphnia magnat MATC > 0.22 < 0.35 ppb
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Avian Reproduction Studies
Bobwhite quail: Environmental concentrations of up to
2.0 ppm do not present a reproductive hazard
Mallard duck: No reproductive related effects were seen at
2.0 ppm (HOT).
Environmental Fate and Ground Water Characteristics:
Hydrolysis: Stable at environmental pH (pH 6-8) and temperature of
25 °C.
Aerobic Soil Metabolism: Degrades under aerobic soil conditions
with a half-life of 33 to 34 days. Fenpropathrin degrades to des-
phenylfenpropathrin and other minor metabolites which undergo
further degradation to CO .
Mobility/Leaching: Soil column leaching data show that fenpropathris
and its aged residues are unlikely to leach in most soils. However,
some leaching may occur in sand soils very low in organic matter
(e.g., 0.1% organic matter).
Environmental Fate and Surface and Ground Water Contamination Concerns:
No concerns at this time.
Exposure of Humans and Nontarget Organisms to Chemical or Degradates:
Applicator exposure in greenhouse: Fenpropathrin is not highly
toxic by the dermal or inhalation route; however, the formulated
product can be irritating to the eyes. Goggles or a face shield
will provide protection to the eyes in case of accidental splashing
during mixing/loading and during spraying.
Exposure During Reentry Operations: No special precautions needed
in greenhouses once spray residues are dry.
Tolerance Assessment
Not applicable for greenhouse ornamental crops.
4. Summary of Regulatory Position and Rationale
The Agency has determined that it should allow the unconditional
registration of fenpropathrin to control pes£s for greenhouse use
since all of the data required to support this use pattern have
been submitted, reviewed and found acceptable. Adequate data are
available to assess the acute and chronic effects of fenpropathrin
to humans. Based on exposure to aquatic organisms and terrestrial
wildlife from greenhouse usage, adverse effects to nontarget organisms
and endangered species are unlikely. Likewise, surface and ground-
water contamination is unlikely from greenhouse usage.
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5. Summary of Data Gaps
None
6. Required Unique Labeling Summary
The following use limitations must appear on products registered for
use in greenhouses:
o For commercial greenhouse use only.
o Do not reenter treated areas until sprays have dried.
o Do not apply this product through any type of irrigation
system.
o Appropriate personal protective equipment and work safety
statements must appear on the label of products registered
for use on/in lath house, shade house, and greenhouse.
7. Contact Person at EPA
George T. LaRocca
Product Manager 15
Insecticide-Rodenticide Branch
Registration Division (H7505C)
Office of Pesticide Programs
U.S. Environmental Protection Agency
401 M Street SW.
Washington, DC 20460
Office location and telephone number;
Rm. 203, CM #2
1921 Jefferson Davis Highway
Arlington, VA 22202
(703) 557-2400
DISCLAIMER: The information presented in this Chemical Information Fact
Sheet is for informational purposes only and may not be used to fulfill
data requirements for pesticide registration and reregistration.
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vvEPA
United States
Environmental Protection Agency
Office of Pesticide Program (H7504C)
PMSD, Information Services Branch
401 M Street, SW
Washington. DC 20460
Official Business
Penalty for Private Use S300
First-Class
Postage and Fees Paid
EPA
Permit No G-35
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