- 90/oS I
Pesticide Fact Sheet Number 211: Oryzalin
PB90-173949
(U.S.) Environmental Protection Agency, Washington, DC
30 Jun 87
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J
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50277-101
REPORT DOCUMENTATION
PAGE
1. REPORT NO.
4. Title and Subtitle
EPA Pesticide Fact Sheets - Oryzalin
No. 211
7. Authors)
EPA, Office of Pesticide Programs, Special Review & Rereg. Div.
90-17
5. R«oort Date
June 30. 1987
8. Performing Organization Rapt. No.
540/FS-90-081
9. Performing Organization Nam* and Address
U.S. Environmental Protection Agency
Office of Pesticide Programs
Special Review & Reregistration Division (H7508C)
•401 M Street, S.W.
Washington, D.C. 20460
10. Project/Task/Work Unit No.
11. Contract(C) or Grant(G) No.
(C)
(G)
12. Sponsoring Organization Name and Address
same as #9
13. Type of Report & Period Covered
14.
IS. Supplementary Notes
16. Abstract (Limit: 200 words)
This document contains up-to-date chemical information, including a summary of
the Agency's regulatory position and rationale, on a specific pesticide or group of
pesticides. A Fact Sheet is issued after one of the following actions has occurred.
1. Issuance or reinssuance of a registration standard,
2. Issuance of 2ach special review document,
3. Registration of a significantly changed use pattern,
4. Registration of a new chemical, or
5. An immediate need for information to resolve controversial issues
relating to a specific chemical or use pattern.
17. Document Analysis a. Descriptors
Pesticides, regulations, Chemical Information Fact Sheet, Use Patterns, science
findings.
b Identifiers/Open-Ended Terms
c COSATI Field/Group
[8. Availability Statement
Publicly Available
REPRODUCED BY
U S. DEPARTMENT OF COMMERCE
NATIONAL TECHNICAL INFORMATION SERVICE
SPRINGFIELD. VA. 22161
19. Security Class (This Report)
unclassified
?0 'Jecurity Class (This Page)
unclassified
21. No of Pages
22.
i
(See ANSI-Z39 18)
OrTIONAL FORM 272 (4-77)
(Formerly NTIS-3S)
Department of Commerce
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Unitta SMM OMitf of e(««raM« I1S-7MC1
WMiMfton. DC 2OMO
540/FS-90-081
£EPA Pesticide
_ Fact Sheet
Name of Chemical: Oryzaiin
Reason for issuance* Registration Standard
Date teuedTSIJ'JUN 1987
Fact Sheet Number: 211
1. DESCRIPTION OP CHEMICAL
Generic Name: Oryzaiin
Common Name: Oryzaiin (WSSA, BSI, ISO, ANSI);
EL-119 (Code Number)
Trade Names: Surflar*, Ryzelan*
EPA Shaughnessy Code: 104201
Chemical Abstracts
Service (CAS) Number: 19044-88-3
Year of Initial
Registration: 1974
Pesticide Type: Herbicide
Chemical Family: Dlnitroanillne
U.S. And Foreign
Producers: Eli Lilly Company
2. USE PATTERNS AND FORMULATIONS
Application Sites: To control annual grasses and broadleaf
weeds in fruit, nut crops, vineyards (bearing and
nonbearlng), soybeans, cotton (Texas only), Peas
(English and green), tobacco (air- and flue-cured),
potatoes (white), small grains (wheat and barley),
forestry and Christmas tree plantations, established
ornamentals, and noncropland areas.
Mechanism of Action: When applied to soil and with adequate
rainfall or irrigation, oryzalin affects physiological
growth processes associated with seed germination.
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Types or Formulations: Emulsifiable concentrate, flovable
liquid concentrate, and wettable powder.
Types and"Methods of Application: Aerial and ground
sprays, application through irrigation systems.
» r
Application Rates: Vary from 0.28 to 6.0 Ibs of active
ingredient per acre depending upon the use site,
weeds to be controlled and soil conditions.
3. SCIENCE FINDINGS
Summary Science Statement: Oryzalln has been found to be
oncogenlc in rats and has been classified as a
Group C carcinogen. Oryzalin is not acutely toxic
in general.
Chemical Characteristics:
Physical State: Crystalline
Color:
Odor:
Vapor pressure
Melting Point:
Flannnabillty:
Yellow-orange
None
< 1 X 10-7 mm Hg at 30°C
141°C to U2°C
Technical material is a flammable
solid. No special precautions for end-
use products.
Solubility 25°C: Solvent
Water
Acetone
Acetonltrile
Benzene
Dieloromethane
Methanol
Methyl cellosolve
Xylene
Ethanol
Hexane
g/100 ml
.00025 (2.5 ppm)
>50
73
5
50
0.2
readily soluble
insoluble
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Toxicological Characteristics:
Acute Effects:
Acute Oral Toxlcity:
>10 g/kg (Rat, In 5* acacia)
>5 g/kg (Rat, Irr'DMSO)
>1 g/kg (Dog) (Toxlclty Category III)
Acute Dermal Toxlclty: >2 g/kg (rabbit) (Toxlclty Category III)
Acute Inhalation
Toxlclty (75WP):
>3.56 mg/1 (Toxlclty Category III)
Primary Eye Irritation: Slight corneal damage (Toxlclty
Category III)
Major Routes of
Exposure:
Chronic Effects:
F-3^ rat - one year:
86C3P1 mouse - one
year:
Oncogeniclty:
rat - two year:
B6C3F1 raouse -
year:
Reproduction:
Teratology:
Rat:
two
Dermal, Inhalation.
Minimal toxlclty was observed at the
medium and highest dose levels of
900 ppm and 2700 ppm In the feed.
NOEL determined to be 500 ppm
in the diet.
Increases In thyroid gland tumors,
three different groups of skin
tumors, and mammary gland tumors
were observed. Oryzalln is
considered to be oncogenlc
to rats based on this study.
Negative for oncogenlclty with slight
weight decrease and detectable organ
effects.
NOEL of 250 ppm.
No teratogenlc effects observed at 2250
ppm (225 mg/kg) in the diet; the NOEL
for teratogenicity following oral intub-
ation is at least 225 mg/kg/day.
Dutch Belted Rabbits: NOEL of at least 125 rag/kg/day.
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Mutageniclty: histldlne auxotrophs of Salmonella
typhlmurlum indicate no mutagenic effect from 0.1
to 1,^00 ug/ral.
Chromosomal Aberrations: Oryzalin did not result in an
increase In dominant lethal mutations In the Wistar
rat.
Primary DNA Damage: Oryzalin administered intraperltoneally
Induced sister chromatld exchanges (SCEs), however,
oryzalin administered orally did not induce SCEs in
the bone marrow of Chinese hamsters.
Physiological and Biochemical Behavioral Characteristics:
Metabolism: Harlan male rats - 40% excreted in urine and
40!? in feces in 3 days. Other studies with rabbits, a
400-pound steer and Rhesus monkeys demonstrated similar
high rates of elimination of oryzalin.
Environmental Characteristics:
Preliminary adsorption and leaching characteristics:
Oryzalin is leached to a limited extent under natural
rainfall conditions depending upon soil organic matter
and clay content. These characteristics are not
adequately understood.
Resultant average persistence: Preliminary field studies
with 14C oryzalin have indicated a relatively short
anaerobic half-life.
Ecological Characteristics: Data are sufficient to characterize
oryzalin as practically nontoxic to birds, and laboratory
and field studies indicate no undue hazard to fish.
Tolerance Assessment:
List of crops and tolerances: (CPR 40 180.304)
Commodity Tolerance (ppm)
Almond, hulls 0.05
Avocados 0.05
Citrus fruits 0.05
Cottonseed 0.05
Pigs 0.05
Kiwifrults 0.05
Nuts 0.05
Olives 0.05
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Commodity Tolerance (ppm)
Peas (succulent) 0.05
Peppermint hay 0.05
Pistachios ' 0.05
Pome fruit 0.05
Pomegranates 0.05
Potatoes 0.05
Small fruits 0.05
Soybeans 0.1
Spearmint hay 0.05
Stone fruits 0.05
Sweet potatoes 0.05
Results of Tolerance Assessment: PADI In humans Is 0.013
mg/kg/day, with NOEL of 12.50 ng/kg/day and a safety
factor of 1,000. These figures may be refined by the
two-year dog study required by the Registration Standard.
4. SUMMARY OF REGULATORY POSITION AND RATIONALE
Use, Formulation or Geographic Restrictions: Manufacturing-use
products may only be formulated Into end-use products
intended for use as an herbicide on fruit, nut crops,
vineyards (bearing and nonbearing), soybeans, cotton
(Texas only), peas (English or green), tobacco (air- and
flue-cured), potato (white), small grains (wheat and
barley), forestry and Christmas tree plantations, estab-
lished ornamentals, and noncropland areas.
Unique label warning statements:
All Manufacturing-use Products
"Do not discharge effluent containing this product
into lakes, streams, ponds, estuaries, oceans, or
public waters unless this product Is specifically
identified and addressed In a NPDES permit. Do not
discharge effluent containing this product to sewer
systems without previously notifying the sewage
treatment plant authority. For guidance contact
your State Water Board or Regional Office of the EPA."
End-use Products
"Do not graze or feed forage from treated fields or
orchards to livestock."
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"Mixer/loader/applicators must wear protective
clothing, consisting of coveralls, a long-sleeved
shirt, shoes and Impermeable gloves when handling
this product."
Non-granular End-use Products
"Do not apply directly to water or wetlands. Do not
contaminate water by cleaning of equipment or
disposal of wastes."
End-use Products Applied by Center Pivot Irrigation
Systems: The labels of these products must bear a
posting requirements statement and the appropriate
chemlgatlon instructions, as specified in the
Registration Standard.
5. SUMMARY OF MAJOR DATA GAPS
Data required
Product Chemistry
Nature of residues
(Metabolism)
Chronic toxicity (dcg)
Hydrolysis
Photodegradation
Soil metabolism studies
Leaching and adsorption/
desorption
Volatility (lab)
Dissipation studies - field
Rotational crops - confined
Pish accumulation
Accumulation in aquatic
non-target organisms
Due Date (after issuance
of the Standard!
6-12 months
18 months
11/15/86*
9 months
9 months
27 months
12 months
12 months
27 months
39 months
12 months
12 months
« Study re-elved 12/86.
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6. CONTACT PERSON AT EPA
Bobert J. Taylor
U.S.-Environmental Protection Agency (TS-767C)
HOI M Street S.V.
Washington, DC 20460
(703) 557-1800
DISCLAIMER: The Information presented In this Pesticide Pact
Sheet Is for Informational purposes only and may not be used
to fulfill data requirements for pesticide registration and
reregistration.
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