- 90/oS I
       Pesticide Fact Sheet Number  211: Oryzalin
                                                                 PB90-173949
       (U.S.)  Environmental Protection Agency, Washington, DC
       30 Jun  87
L
J


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 50277-101
  REPORT DOCUMENTATION
         PAGE
                          1. REPORT NO.
  4. Title and Subtitle
   EPA Pesticide Fact Sheets -  Oryzalin
   No. 211
  7. Authors)
   EPA, Office of Pesticide Programs,  Special Review & Rereg.  Div.
                          90-17
                                                                          5. Roort Date
                                                                            June 30.  1987
               8. Performing Organization Rapt. No.

                 540/FS-90-081	
  9. Performing Organization Nam* and Address
   U.S.  Environmental Protection Agency
   Office of Pesticide Programs
   Special  Review & Reregistration Division  (H7508C)
  401 M Street,  S.W.
   Washington, D.C.  20460	
                                                                          10. Project/Task/Work Unit No.
               11. Contract(C) or Grant(G) No.

               (C)

               (G)
  12. Sponsoring Organization Name and Address

   same as #9
                                                                          13. Type of Report & Period Covered
                                                                          14.
  IS. Supplementary Notes
  16. Abstract (Limit: 200 words)

        This document contains up-to-date chemical  information, including a summary of
   the Agency's regulatory position and rationale,  on a specific pesticide or group of
   pesticides.  A Fact Sheet is issued after one of the following actions has occurred.

        1.   Issuance or reinssuance of a registration standard,
        2.   Issuance of 2ach special review document,
        3.   Registration of  a significantly changed use pattern,
        4.   Registration of  a new chemical, or
        5.   An immediate need for information to resolve controversial issues
             relating to a specific chemical or use  pattern.
 17. Document Analysis  a. Descriptors
    Pesticides, regulations,  Chemical  Information Fact Sheet, Use Patterns,  science
    findings.
    b  Identifiers/Open-Ended Terms
    c COSATI Field/Group

 [8. Availability Statement

    Publicly  Available
                                 REPRODUCED BY
                                 U S. DEPARTMENT OF COMMERCE
                                 NATIONAL TECHNICAL INFORMATION SERVICE
                                 SPRINGFIELD. VA. 22161
19. Security Class (This Report)

unclassified
?0  'Jecurity Class (This Page)
unclassified
                           21. No of Pages
                                                                                      22.
                                                                                     i
(See ANSI-Z39 18)
                          OrTIONAL FORM 272 (4-77)
                          (Formerly NTIS-3S)
                          Department of Commerce

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                 Unitta SMM           OMitf of e(raM I1S-7MC1
                                  WMiMfton. DC 2OMO
                                                     540/FS-90-081
EPA      Pesticide
               _ Fact Sheet
                 Name of Chemical:  Oryzaiin
                 Reason for issuance*  Registration Standard
                 Date teuedTSIJ'JUN 1987
                 Fact Sheet Number:  211
  1.  DESCRIPTION OP CHEMICAL

      Generic Name:             Oryzaiin

      Common Name:              Oryzaiin (WSSA,  BSI, ISO, ANSI);
                               EL-119 (Code Number)

      Trade Names:              Surflar*, Ryzelan*

      EPA Shaughnessy Code:     104201

      Chemical Abstracts
        Service (CAS) Number:   19044-88-3

      Year of Initial
        Registration:           1974

      Pesticide Type:           Herbicide

      Chemical Family:          Dlnitroanillne

      U.S. And Foreign
        Producers:              Eli Lilly Company

  2.  USE PATTERNS AND FORMULATIONS

      Application Sites:  To control annual grasses and broadleaf
           weeds in fruit, nut  crops, vineyards  (bearing and
           nonbearlng), soybeans, cotton (Texas  only), Peas
           (English and green), tobacco (air- and flue-cured),
           potatoes (white), small grains (wheat and barley),
           forestry and Christmas tree plantations, established
           ornamentals, and noncropland areas.

      Mechanism of Action:  When applied to soil and with adequate
           rainfall or irrigation, oryzalin affects physiological
           growth processes associated with seed germination.

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                          - 2 -
    Types or Formulations:  Emulsifiable concentrate, flovable
         liquid concentrate, and wettable powder.

    Types and"Methods of Application:  Aerial and ground
         sprays, application through irrigation systems.
                                                r
    Application Rates:  Vary from 0.28 to 6.0 Ibs of active
         ingredient per acre depending upon the use site,
         weeds to be controlled and soil conditions.

3.  SCIENCE FINDINGS

    Summary Science Statement: Oryzalln has been found to be
         oncogenlc in rats and has been classified as a
         Group C carcinogen.  Oryzalin is not acutely toxic
         in general.

    Chemical Characteristics:

        Physical State:  Crystalline

        Color:

        Odor:

        Vapor pressure

        Melting Point:

        Flannnabillty:
Yellow-orange

None

< 1 X 10-7 mm Hg at 30C

141C to U2C
Technical material is a flammable
solid.  No special precautions for end-
use products.
       Solubility 25C:  Solvent
                         Water
                         Acetone
                         Acetonltrile
                         Benzene
                         Dieloromethane
                         Methanol
                         Methyl cellosolve
                         Xylene
                         Ethanol
                         Hexane
                     g/100 ml

                     .00025 (2.5 ppm)
                     >50
                     73
                     5
                     50
                     0.2
                     readily soluble
                     insoluble

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                       - 3 -
Toxicological Characteristics:

    Acute Effects:
    Acute Oral Toxlcity:
        >10 g/kg (Rat, In 5* acacia)
        >5 g/kg (Rat, Irr'DMSO)
        >1 g/kg (Dog) (Toxlclty Category III)
    Acute Dermal Toxlclty:  >2 g/kg (rabbit)  (Toxlclty Category III)
    Acute Inhalation
      Toxlclty (75WP):
        >3.56 mg/1 (Toxlclty Category III)
    Primary Eye Irritation: Slight corneal damage (Toxlclty
                                Category III)
    Major Routes of
      Exposure:

    Chronic Effects:

    F-3^ rat - one year:


    86C3P1 mouse - one
       year:


    Oncogeniclty:

          rat - two year:
    B6C3F1 raouse -
       year:
    Reproduction:

    Teratology:

    Rat:
two
        Dermal, Inhalation.
        Minimal toxlclty was observed at the
        medium and highest dose levels of
        900 ppm and 2700 ppm In the feed.

        NOEL determined to be 500 ppm
        in the diet.
Increases In thyroid gland tumors,
three different groups of skin
tumors, and mammary gland tumors
were observed.  Oryzalln is
considered to be oncogenlc
to rats based on this study.

Negative for oncogenlclty with slight
weight decrease and detectable organ
effects.

NOEL of 250 ppm.
        No teratogenlc effects observed at 2250
        ppm (225 mg/kg) in the diet;  the NOEL
        for teratogenicity following  oral intub-
        ation is at least 225 mg/kg/day.
    Dutch Belted Rabbits:    NOEL of at least  125  rag/kg/day.

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                          - 4 -
    Mutageniclty:  histldlne auxotrophs of Salmonella
        typhlmurlum indicate no mutagenic effect from 0.1
        to 1,^00 ug/ral.

    Chromosomal Aberrations: Oryzalin did not result in an
        increase In dominant lethal mutations In the Wistar
        rat.

    Primary DNA Damage:  Oryzalin administered intraperltoneally
        Induced sister chromatld exchanges (SCEs), however,
        oryzalin administered orally did not induce SCEs in
        the bone marrow of Chinese hamsters.

Physiological and Biochemical Behavioral Characteristics:

Metabolism:  Harlan male rats - 40% excreted in urine and
    40!? in feces in 3 days.  Other studies with rabbits, a
    400-pound steer and Rhesus monkeys demonstrated similar
    high rates of elimination of oryzalin.

Environmental Characteristics:

    Preliminary adsorption and leaching characteristics:
      Oryzalin is leached to a limited extent under natural
      rainfall conditions depending upon soil organic matter
      and clay content.  These characteristics are not
      adequately understood.

    Resultant average persistence: Preliminary field studies
      with 14C oryzalin have indicated a relatively short
      anaerobic half-life.

Ecological Characteristics: Data are sufficient to characterize
    oryzalin as practically nontoxic to birds, and laboratory
    and field studies indicate no undue hazard to fish.

Tolerance Assessment:

    List of crops and tolerances:  (CPR 40 180.304)

        Commodity                    Tolerance (ppm)

        Almond, hulls                     0.05
        Avocados                          0.05
        Citrus fruits                     0.05
        Cottonseed                        0.05
        Pigs                              0.05
        Kiwifrults                        0.05
        Nuts                              0.05
        Olives                            0.05

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                             - 5 -


           Commodity                    Tolerance (ppm)

           Peas (succulent)                  0.05
           Peppermint hay                    0.05
           Pistachios                     '   0.05
           Pome fruit                        0.05
           Pomegranates                      0.05
           Potatoes                          0.05
           Small fruits                      0.05
           Soybeans                          0.1
           Spearmint hay                     0.05
           Stone fruits                      0.05
           Sweet potatoes                    0.05

    Results of Tolerance Assessment:  PADI In humans Is 0.013
       mg/kg/day, with NOEL of 12.50 ng/kg/day and a safety
       factor of 1,000.  These figures may be refined by the
       two-year dog study required by the Registration Standard.

4.  SUMMARY OF REGULATORY POSITION AND RATIONALE

    Use, Formulation or Geographic Restrictions: Manufacturing-use
       products may only be formulated Into end-use products
       intended for use as an herbicide on fruit, nut crops,
       vineyards (bearing and nonbearing), soybeans, cotton
       (Texas only), peas (English or green), tobacco (air- and
       flue-cured), potato (white), small grains (wheat and
       barley), forestry and Christmas tree plantations, estab-
       lished ornamentals, and noncropland areas.

    Unique label warning statements:

       All Manufacturing-use Products

           "Do not discharge effluent containing this product
           into lakes, streams, ponds, estuaries, oceans, or
           public waters unless this product Is specifically
           identified and addressed In a NPDES permit.   Do not
           discharge effluent containing this product to sewer
           systems without previously notifying the sewage
           treatment plant authority.  For guidance contact
           your State Water Board or Regional Office of the EPA."

       End-use Products

           "Do not graze or feed forage from treated fields or
           orchards to livestock."

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                              - 6 -
            "Mixer/loader/applicators must wear protective
            clothing, consisting of coveralls, a long-sleeved
            shirt, shoes and Impermeable gloves when handling
            this product."
        Non-granular End-use Products
           "Do not apply directly to water or wetlands.  Do not
            contaminate water by cleaning of equipment or
            disposal of wastes."
        End-use Products Applied by Center Pivot Irrigation
            Systems: The labels of these products must bear a
            posting requirements statement and the appropriate
            chemlgatlon instructions, as specified in the
            Registration Standard.
    5.  SUMMARY OF MAJOR DATA GAPS
          Data required

          Product Chemistry
          Nature of residues
            (Metabolism)
          Chronic toxicity (dcg)
          Hydrolysis
          Photodegradation
          Soil metabolism studies
          Leaching and adsorption/
            desorption
          Volatility  (lab)
          Dissipation studies - field
          Rotational crops - confined
          Pish accumulation
          Accumulation in aquatic
             non-target organisms
Due Date (after issuance
    of the Standard!
  6-12 months
  18 months

  11/15/86*
  9  months
  9  months
  27 months
  12 months
  12 months
  27 months
  39 months
  12 months
  12 months
 Study re-elved 12/86.

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                          - 7 -


6.  CONTACT PERSON AT EPA

         Bobert J. Taylor
         U.S.-Environmental Protection Agency (TS-767C)
         HOI M Street S.V.
         Washington, DC  20460
         (703) 557-1800
DISCLAIMER: The Information presented In this Pesticide Pact
Sheet Is for Informational purposes only and may not be used
to fulfill data requirements for pesticide registration and
reregistration.

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