Qc-
^
Chemicals Identified In
Human Biological Media,
A Data Base
Fourth Annual Report
October 1982
Volume V Part 2
-------
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for use.
-------
EPA 560/5-82-003B
ORNL/EIS-163/V5-P2
CHEMICALS IDENTIFIED IN HUMAN BIOLOGICAL MEDIA,
A DATA BASE
Fourth Annual Report, October 1982
Volume V, Part 2
Records 6012-7587
Compiled by
M. Virginia Cone, Margaret F. Baldauf, Dennis M. Opresko,
and Mary S. Uziel
Chemical Effects Information Center
Information Center Complex
Information Division
OAK RIDGE NATIONAL LABORATORY
Oak Ridge, Tennessee 37830
operated by
UNION CARBIDE CORPORATION
for the
DEPARTMENT OF ENERGY
Contract No. W-7405-eng-26
This effort was accomplished under the aegis
of the Interagency Collaborative Group on
Environmental Carcinogenesis, National Cancer
Institute, National Institutes of Health,
Chairperson, Dr. Herman F. Kraybill.
Date Published — December 1982
Cindy Stroup, Project Officer
Design and Development Branch
Exposure Evaluation Division
Office of Toxic Substances
U.S. Environmental Protection Agency
Washington, D.C. 20460
-------
CONTENTS
Part 1
Acknowledgments v
Introduction 1
Users' Guide 3
Abbreviations for Analytical Methods 7
References for Data Base 9
References for Physical and Chemical Data 43
Appendix A. Journals Searched 47
Appendix B. Chemicals in Data Base (1979-1982) by CAS
Preferred Names 51
Appendix C. Chemicals (1982) by CAS Registry Numbers and
Preferred Names 79
Appendix D. Cross-Referenced Chemical Lists 97
CAS Preferred Names — Common Names 99
Common Names — CAS Preferred Names 131
Appendix E. Tissues and Body Fluids in Data Base
(1979-1982) 279
Indices 283
Author 285
Corporate Author 299
Tissue 313
Keyword 315
Directory of Chemicals (1982) 323
CAS Preferred Names 325
Formulas 337
Part 2
Data Base
Nondrugs 1
Drugs 327
111
-------
NONDRUGS
-------
Acetaiaehyde
75-07-0
C2-HI4-0
9« 04.05, MP -123.5 C, BP 20.8 C
TISSDE
6012
Breath
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC/BS
HO.IBEE
OF CASES
23
RANGE
2-15 ng/1
._
HEAD
5.5 ng/1
GENERAL INFOR1UTION
Estiaated from graph
during study to lininize number and
anount of exogenous constituents.
ACOITS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COHPOUNDS; CHLOEOBESZENES
EEFEBENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio. fl.p.A.
1977
Journal of
chronatographic Science
15:239-2"it
Acetic acid ethyl ester
1141-78-6
CD-H8-02
B« 88.10, «P -83.6 C, BP 77.15 C, VP 100 urn Hg at 27.0 C
TISSUE
6013
Breath
EXPOSURE ROUTE
ANALYTICAL
BETHOD
GC/BS
NUKBER
OF CASES
28
BANGS
0.04-14 ng/1
Hi AN
0.« ng/1
GESE6AL IHFOBBATION
Estinated from graph
Healthy 18-60 yr olds, nonsaofcers.
Rigid protocol 114 days before and
during study to Bininize nunber and
AtOLTS; BREATH; 11COBOLS; CH10BISE
OBGANIC COBPOOHDSJ CHLOBOBENZENES
BEFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, H.p. A.
1977
Chronatographic Science
15:239-2411
-------
Acetic acid, (2,4-dichlocophenoxy)-
9U-75-7
C8-H6-C12-03
«» 221.04, HP 138 C, BP 160 C at 0.4 mm Hg
TISSUE
601 a
Orine
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC
son BEE
OF CASES
18
RANGE
a) Hone aetected-0. 002 15
ng/fcg
b) Hone detected-0.0557
•g/fcg
c) 0.0011-0.0377 ng/kg
d) Hone detected-0. 00056
ug/fcg
e) None detected-0. 0237
ng/kg
f ) Hone detected-0. 0219
mg/kg
MEAN
a) 0.00082 mg/kg
b) 0.0128 ig/kg
c) 0.0104 mg/kg
d) 0.00024 ag/kg
e) 0. 008 1 mg/kg
f) 0.0046 «g/kg
GENERAL INFORMATION
a) Cre 1 , 6 subjects
t) Cre 2, 6 subjects
c) Cre 3, 6 subjects
d) Cre 1, 6 subjects
e) Cre 2, 6 subjects
f) Cre 3, 6 subjects
aj-c) Custoiary clothing and norsal
precautions. Dermal exposure, none
detected- 0.091 1 ag/kg
clothing and special hygienic
practices. Deraal exposure, none
detected-0. 0216 >g/kg
Application 2 Ib acid equivalent/acre
to 100-acre tract requiring 41-78
nin/treatnent for loading and
spraying
Total excreted on spray day plus 5
days thereafter
Air levels below linit of detection
(0.05 ug) in 32 of 33 tests
laboratory procedures
Helicopter crews (pilot, nechanic.
b atchaan- loader , supervisor, and 2
observers), HA and OR, 1980
OREGOH; HASHISGTON; URINE; CHLOBINE
CBGAHIC COHPOOHDS; PESTICIDES; CROP
COSTING; OCCUPATIONAL HAZABDS:
PESTICIDE RESIDUES
REFERENCE
Lavy, T.I.
Halstad, J.D.
Flynn, E.F.
Hattice, J.D.
1982
Journal of Agricultural
and Food Chemistry
30:375-381
cetic acid, allyl ester (8 CI)
cetic acid, 2-propenyl ester (9 CI)
91-67-7
5-H8-02
W 100.13, BP 10H C
6015
Breath
EXPOSURE ROUTE
ANALYTICAL
BETHOD
GC/HS
NDHBEB
OF CASES
28
EANGE
0.09-0.9 ng/1
BEAM
0.3 ng/1
GENEBAL ISFOSPIATICH
Estimated fro. graph
Rigid protocol 14 days before and
during study to •ici*ize number and
aaount of exogenous constituents.
ACULTS; BRE1TH; ALCOHOLS; CHLORIHE
ORGANIC CONPOONDS; CHLOPOB EHZEN ES
EEFESEHCE
Krotoszynski, B.
Gabriel, G.
Claudio, (I. P. A.
1977
Journal of
Chronatographic Science
15:239-244
-------
Acetic acid, octyl ester
1 12-1U-1
C10-H20-02
B« 172.27, HP -38.5 C, BP 210 C
| TISSUE
I
|
I
I 6016
1 Breath
1
1
1
1
1
1
1
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC/HS
NOHBEE
OP CASES
0.028-0.18 ng/1
0. 13 ng/1
GENERAL INFORMATION
Estiaated froa graph
Healthy 18-60 yr oLds, nonsaokers.
Rigid protocol 14 days before and
during study to ainiaize number and
aaount of exogenous constituents.
ADULTS; BRIATB; ALCOHOLS; CHLORINE
OEGASIC COMPOUNDS; CHLOROB1NZENES
Krotoszynski, B.
Gabriel, G.
O'Seill, H.
Claudio, fl.P.A.
1977
Journal of
Chroaatographic Science
15:239-2»»
Acetic acid, phenyl- (8 CI)
Eenzeneacetic acid (9 CI)
103-82-2
C8-H8-02
(IB 136.11, HP 76.7 C, BP 265.5 C, It T m Hg at 97.0 C
I TISSUE
1
1
I
I 6017
| Breath
I
|
1
1
1
1
1
1
EXPOSURE ROUTE
ANALYTICAL
METHOD
ac/ns
S01EEF:
OF CASES
28
BANGE
0.065-0.61 ng/1
HEiN
0.20 ng/1
GEBEEAL IHFORHATICH
Estinated froa graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 14 days before and
during study to linioize nunber and
anoun,t of erogenous constituents.
AtDLTS; BREATH; ALCOHOLS; CHLOBIKE
OEGABIC COHPOOBDS; CHLOROBIHZEBES
Krot
Gabr
O'Be
Clau
1977
Jcur
Chro
15:2
Krotoszynski, B.
iriel, G.
leill, H.
mdio, H. p. A.
'7
irnal of
Chronatographic Science
Ln
Acetic acid, phenyl-, ethyl ester (8 CI)
Benzeneacetic acid, ethyl ester (9 CI)
101-97-3
C10-H 12-02
118 164.2, «P 276 C, BP 227 C
| TISSUE
I
|
1
I 6018
I Breath
1
1
I
1
1
1
1
1
EXPOSURE ROUTE
ABAIITICAL
METHOD
GC/MS
HUMEER
OF CASES
28
RANGE
0.1-1.5 ng/1
HEAN
0.75 ng/1
GENERAL INFORMATION
Estimated froa graph
Healthy 18-60 yr olds, nonsaokers.
during study to Biniaize nuaber and
ATCLTS: BREATH; ALCOHOLS; CHLORINE
ORGANIC COMPOUNDS; CHLOROBEHZEHES
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, B.
Claudio, n. P. A.
1977
Chroaatographic Science
15:239-2»«
-------
Acetic acid, propyl ester
1C9-60-*
C5-H10-02
BH 102.13, HP -92.5 C, BP 101.6 C, VP to mm Hg at 28.8 C
6019
Breath
EXPOSOBE POUTE
ANALYTICAL
HETHOD
» OF! BEE
OP CASES
2.8-9 ng/1
t.8 ng/1
GENERAL INFOPBATION
Estimated from graph
Healthy 18-60 y r olds, nonsmokers.
Eigid protocol 14 days before and
during study to tinimize nunber and
amount of exogenous constituents.
ftEDLTS; BREATH; ALCOHOLS; CHLOEINE
CEGANIC COMPOONDS; CHLOROBEHZESBS
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, H.P.A.
1977
Journal of
ChromatograpKic Science
15:239-211
Acetic acid, thio- (8 CI)
Ithanethioic aci4 (9 CI\
507-09-5
C2-H4-0-S
B« 76.11, HP <-17 C, BP 93 C, VP 1 »» Hg at 60.0 C
f020
Br e at h
EXPOSURE POOTE
ANALYTICAL
BETHOD
SOBBEE
OF CASES
23
EAHGE
2.3-3.2 ag/1
».2 ng/1
GE8EEAL IBF08HATIOH
Estimated from graph
Healthy 18-6Q yc olds, nousmokers.
Pigid protocol 14 days before and
during study to Binimize number and
amount of exogenous constituents.
AID1TS; BEEATB; JIICOHOLS; CH10BIHE
OEG»»IC COHPOOHDS; CHLOEOBESZENES
KrotoszynsXi, B.
Gabriel, G.
O'Neill, H.
Claudio, H. P. A.
1977
Journal of
Chronatographic Science
15:239-2411
Acetoacetic acid, butyl ester (8 CI)
Butanoic acid, 3-oxo-, butyl ester (9 CI)
591-60-6
C8-H11-03
BB 158.20, HP -35.6 C, BP 211 C
TISSDE
6021
Breath
EXPOSU8E BODTE
imlYTICAL
BETHOD
GC/BS
NDBBES
OF CASES
28
ItiBGE
0.1-0.75 ng/1
Hi
0.27 ng/1
GESERAL IBFORHATICH
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 14 days before and
during study to ainimize number and
amount of exogenous constituents.
AiniTS; BBEATH; ALCOHOLS; CHLORINE
OEGJ1UC COBPOONDSj CHLOEOBENZEHES
EEFESENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, H. P. A.
1977
Journal of
chromatographic Science
15:239-241
-------
Acetone (6 CI)
2-Propanone 19 CI)
67-61-1
C3-H6-0
BW 58.08, BP -94.6 C, BP 56.18 C, VP 400 urn Hg at 39.5 C
TISSUE
6022
Breath
EXPOSURE ROUTE
ANALYTICAL
METHOD
SO/US
NUBBER
OF CASES
28
RANGE
75-220 ng/1
BEAN
150 ng/1
GENERAL INFORBATION
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
Blgid protocol \t days before and
during study to liniaize number and
amount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHIOEIKE
OBGiHIC COBPOIJIIDS; CHLOEOBISZEBES
EEFERBNCE
Krotoszynski, B.
Gabriel, a.
O'Heill, fl.
claudio, a.?. A.
1977
Journal of
Chronatographic Science
15:239-2U«
Acetonitrile
75-05-8
C2-H3-N
UK HI. 05, »P -H5 C, BP 81.1 C, IF 100
Hg at 27 C
TISSUE
6023
Breath
EXPOSDSE POBTE
ABALYTICAL
BETHOD
GC/HS
NOBBEE
OF CASES
28
EAHGE
7-100 ng/1
flEAB | GEHEEAL IHFOEBATIOH
1
1
I
25 ng/1 t Estinated fron graph
1
1 Healthy 18-60 yr olds, nonsaokers.
| Pigid protocol 1
-------
Alaninun
TU29-90-5
Al
AtW 26.98154, IIP 660 C, BP 2327 C, VP 1 m« Hg at 1540 C
TISSUE
6025
Adrenal
gland
6026
Aorta
6027
Blood
6028
Blood,
plasma
EXPOSURE ROUTE
Dialysis fluid
ANALYTICAL
METHOD
ES
ES
Polarography
AAS
NUBBEB
OF C1SE5
7
7
8
a) 8
b) 13
c) 14
SINGE
Not given
Not given
56-125 ug/1
a) 0.8-1.9 u 10 1/1
b) 1.8-3.1 umol/1
c) 10-51 umol/1
1
37 *or- 23 ppa dry wt
16 +or- 6.4 ppa dry
wt
Not given
a) Not given
b) Hot given
c) Not given
(NEXT PAGE]
GENERAL INFORHATION
Normal tissue
Autopsies
Japan
JAPAN; AD01TS: AUTOPSIES; ADRENAL
GLANDS; AORTA: BONES; HEART;
INTESTINES; ICIDNEIS; LIVBK; LUNGS;
1IBPB NODES; PASCBEJS; SPLIEN;
STOHACH; TBYBOID GLANDS; TRACBEH
AlOBINOH; BAEIDH; CADBI08; CALCIOH;
CBROBlnt!; COBALT; COPPER; IHOS; LEAD;
BAGNESI0B; HANGAIIESE; BETALS;
PCLYBDENOB; NICKIL; PHOSPHCBOS;
POTASSIDB; SILICON; SILVER; SODIOB;
STRONTIOfl; TIN; TITANIOB; VANADIOB;
ZINC; BIOJCCOBOL1TIOB; HBJ1TB
BAZABDS; OCCOPAT10NAL HAZARDS;
TONGDE; ZIBCONIDB; ELEBENTS
Nornal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDHETS ; LIVER; LONGS;
LYBPH NODES: PANCBBAS; SPLIEN;
STOH1CH; IBIROID SL4NDS; TBICHEAJ
ALCBINUB; BABIOB; CADBIDB; CAICIOB;
CBBOBIDB; CCBALT; COPPEB; IBON; LEAD;
BAGNESIOB; BiNGASESE; BETALS;
BCLYBDENOB; NICKEL; EHCSPHCBOS;
POTASSIOB; SILICON: SILVER; SODMB;
STBONTIOB; TIN; TITISIOK; TANADIOK;
ZINC; BIOACCUBULITION; HEALTH
HAZARDS; OCCDPATIONAL BAZABDS;
TCRGUE; ZIBCOHItIB; ELEBENTS
Hevodialysis patients receiving Al
supplements, unknown a>ount-2600 g
32-69 yr olds
FRANCE; BLOOD: BONES; BEASOBEBENT
BETHODS; ALOnlNOK; BETALS
a) patients on continuous ambulator;
peritoneal dialysis (CAPD). CAPD
fluid containing 0.7 tor- 0.4 umol
Al/1
b) Patients on nemo dialysis.
Hemodialysis fluid <1 umol Al/1
c) Same as a). CAPO fluid with 23-54
umol Al/1
Estimated from grapbc
Patients with >18 umol Al/1 had
syiptoms of anorexia, nausea,
vomiting* cramp-like abdominal pain,
veight loss and general malaise
BLOOD PLASBA; HEBODIALYSIS;
BITALS
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
00
Burnel, D.
Hutin, B.F.
Better, P.
Kessler, n.
Huriet, C.
Gaucher, A.
1982
Pathologic Biologic
30(1):27-32
Cuiming, A.D.
Simpson, G.
Bell, D.
Cowie, J.
Hinney, B.J.
1982
Lancet 2(8263):103-104
-------
Aluminum
7U29-90-5
Al
StB 26. 9815H. BP 660 c, BP 2327 C, 7P 1 mm Hg at 15UO C
(CONTINUED)
TISSUE
6029
Eone
6030
Bone
6031
Heart
EXPOSURE E00TE
_
ANAIYTICAL
HETHOD
ES
Polarography
ES
NtMBEB
OF CASES
5
25
a) 8
b) 2
ai i
e) 1
BAHGE
Hot given
a) 10-31.5 ug/gl
b) 10-17.5 ug/g
d) 6-130 ug/g
a) Sot given
b) 8.0-15 ppm
d) Not applicable
e) Hot applicable
Dry wt
(NEXT
MEAN
<15 ppM dry wt
a) 18.8 +or- 5.8 ug/g
b) 13.1 +or- <4.2 ug/^
3) Not given
a) 1 1 *or- 7. 5 ppm
a) 26 pp»
d) 17 ppa
e) 2.0 ppm
Dry v t
PAGE)
GENERAL INFOPFUTION
Norval tissue
Autopsies
JSEHH; ADULTS; ADTOPSIES; »DBE»»L
GUHDS; tOPlt; BONES; H5J5T;
INTESTINES; KIDSEIS; LIVES; LOHGS;
LY8PH NODES; P»HCEE»S; SPLEEN;
STOHACH; TBYEOID GLANDS; TBJCHE*;
tLOniHDn; BASIOd; CiDMIOM: CALCIDB;
CBEOIIIOll; COBALT; COPPER; IBOH; LEAD;
njGNESIOPI; DANCANESE; HETALS;
flCIYBDENIjn; NICK1L; PBOSPHOHOS;
PCTASSIOB; SILICON; SILVBE ; SODIOH:
STBOBTIOB; TIN; TITANIDB; VAHADIUH;
ZINC; BIOACCOBOLATIOK; HEALTH
HAZAEDS; OCCOPATIOHAL HAZARDS;
TCNGDE; ZIBCOHIDB; ELESENTS
a) Femoral bone, 13 orthopedic
patients
subjects
c) Trabecular region, sane as b)
d) 8 Hemodialysis patients receiving
Al supplenents
32-69 yr old henodialysis patients.
ard ^6-85 yr old orthopedic patients
F8AHCE; BLOOD: BONES; BEASOBEMENT
BITHOOS; ALUBINUn; BETALS
a) Normal healthy men
b) Chroniui plating workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AOTOPSIES; ADRENAL
GLANDS; A08TA; BONES; HEART;
INTESTINES; KIDCETS; 1IVEH; LDNGS;
L1BPH NODES; PANCEEAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
JIOBINUB; BARIDB; CADfllOB; CALCIOB ;
CHBOBItlfl; COBALT; COPPER; IBON; LEAD;
BAGNESIOd; BANGANESE; BETALS;
rCLTBDENDB; NICKEL; PHOSPHCBOS;
EOTASSIUB; SILICON; SILVER; SODIOB ;
STBONTIOB; TIN; TITANIOB; VANADIOB;
ZINC; BIOACCOBDLATICN; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TONGUE; ZIRCONIDH; ELEBENTS
BEFEBESCE
Teraoka, H.
1981
Archives of
36(
-------
Aluminum
7129-90-5
U
At« 26.98151, HP 660 C, BP 2327 C, VP 1 mm Hq at 1510 C
(CONTINUED)
TISSUE
6032
Intestine
6033
Kidney
603it
Liver
EXPOSURE POOTE
ANALYTICAL
METHOD
ES
ES
ES
NUBBER
OF CASES
10
a) 8
b) 2
c) 3
d) 1
e) 1
a) 9
b) 2
c) 3
d) 1
e} 1
BANGS
Not given
a) Sot given
b) 14-22 ppm
c) 11-35 ppm
d) Not applicable
e) Not applicable
Dry wt
a) Not given
b) 7.5-8.0 pp»
c) 7.0-52 ppm
d) Sot applicable
e) Not applicable
Dry wt
26 +or- 16 ppm dry
a) 11 tor- 7.2 ppm
b) 18 ppm
c) 25 ppsi
d) 29 ppm
e) 16 ppm
Dry wt
a) 19 -for- 12 ppm
b) 7.8 ppm
c) 29.7 ppm
d) 20 ppm
e) 130 ppm
Dry wt
(NEXT PAGE)
GENERAL INFORBATICN
Normal tissue
autopsies
Japan
JAPAN: ADULTS; AUTOPSIES; ADEENAL
GLANDS; AORTA: BONES; BEAST;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCBEiS; SPLIEN;
STOBBCH; THYROID GLANDS; TRACHEA;
ALcniNun; BAEIUB; CIDSIUB; CALCIOB;
CBEOBIUB; COBALT; COPPER; IRON; LEAD;
BAGNESIUH; HANGANESE; HETALS;
HOLY3DENUB; NICKEL; PHOSPHORUS;
EOTASSIOH; silicos: SILVER; SODIUB;
STEONTID9; TIN; TITANIOH; VANADIOB;
ZINC; BIOACCUnnLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGDE; ZIRCON10B; ELEBE1ITS
a) Normal healthy men
b) Chromium platiDg workers
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADEEBAL
GLANDS; AORTA; BONES; HEAET;
INTESTINES; KIDSEYS; LIVER; LONGS;
1YBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA:
ALOBINUB; BARIDB; CADBIDB; CALCIUB;
CHROBIUB; COBALT; COPPER; IRON; LEAD;
BAGNESIUB; BANGANESE; BETALS;
BOLYBDENOH; NICKEL; PHOSPHORUS;
EOTASSIOM; SILICON; SILVER; SODIUB;
STBONTIUB; TIN; TITANIOB; VANADIUB;
ZINC; BIOACCUHULATICN; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCSGDB; ZISCONIBB; ELEBBHTS
a) Normal healthy nen
b) Chromium plating workers
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BEARI;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPB NODES; PANCREAS; SPLEEN;
STOHACH; THYEOID GLANDS; TRaCHEA;
ALDHINDB; BARIOB; CiDBIDH; CALCIUB;
CBROHIOH; COBALT; COPPER; IRON; LEAD;
HAGNBSIUB; BtNGANESE; BETALS;
BOLYBDENUH; NICKEL; PHOSPHORUS;
EOTASSIUfl; SILICON; SILTED: SODIOH;
S1HOBTIUH; TIB; TITANIUB; VADADIOB;
ZINC; BIO1CCOBULATIOS; HEAITH
HAZARDS; OCCOPITIOBAI HUZiEDS;
TONGUE; ZlaCONIDB; ELEBENTS
Teraoka, H.
1981
Archives of
Enviro&ftent.aL Health
36(4): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
Teraoka. H.
1981
Archives of
Environmental Health
36(1):155-165
-------
Aluminum
7U29-90-5
Al
Atw 26.98154, «P 660 C, BP 2327 C, VP t mm Hg at 1510 C
(CONTINUED)
TISSUE
6035
Liver
6036
Lang
6037
Lymph
no3e
i
I
EXPOSURE ROUTE
I i
ANALYTICAL
METHOD
AST
ISV
ES
ES
NUMBER
OF CASES
30
a) 12
b) 2
c) 3
d) 1
e) 1
a) 3
b) t
c) 3
d) 1
e) 1
RANGE | 9ESN
1.6-2.6 ug/g
?et wt
a) Not given
b) 270-280 ppm
c) 210-110 ppn
d) Not applicable
e) Not applicable
Dry wt
a) Not given
b) Not applicable
c) 390- 1000 ppffl
d) Not applicable
e) Not applicable
Dry wt
1
1
Not given
a) 230 tor- 170 ppm
b) 275 ppm
c) 307 pp»
d) 1«0 ppm
e| 2000 pp»
Dry wt
a) 2000 *or- 600 ppm
b) 500 ppm
c) 627 ppm
d) 1300 ppm
e) 3200 ppm
Dry wt
GENERAL INFORMATION
Category 2 as proposed by
International workshop on Bonitoring
Environmental Materials ana Specimen
Banking (non-pollutant trace element
mcraitorea for "normal" levels)
Autopsies, Baltimore, BD,
Hinneapolis, UN, and Seattle, WA
BABYLAND; MINNESOTA; WASHINGTON:
AOTOPSIES; LIVEE ; MEASUREMENT
BETHODS; ALOBINUB; ANTIHONY; APSENIC;
B»BIUH; CADMIUM; CHEOBIUM; COBALT;
CCPPER; FLUOEINE; IBOS; LEAD;
BABGANESE; flEECOBY; BOIYBDENUB;
NICKEL: RUBIDIUM; SELENIDB: SILVER;
SIRONTIUB; THALLIUM.; TIN; VANADIUB;
2JSC; POPULATION EXPOSURE
a) Normal healthy men
b) Chromium plating workers
c) Chromate refining workers
d) Airplane painter
ej Stone Bason
Autopsies
Japan
JAPAN; ADULTS; AOTOPSIES; ADRENAL
GLAB'DS; AORTA; BONES; HEAFT;
INTESTINES: KIDNEYS; LIVES; LUNGS;
IJePH NODES; PANCEEAS; SPLHEN;
STOdJCH; THYROID GIi»DS; TEJCHEI;
ALOBINUB: BAEIUH; CADMIUB; CALCIUM;
CBROBinS; COEILT; COPPER; IBO»; LEAD;
BAGNESIUB; BABGANESE; HETALS;
BOLYBCEBUH; NICKEL; PHOSPHORUS;
ECTASSIOH; SILICON; SILVER; SODIUM;
S1RONTIOB; TIB; TITABIDB; VABADIUB;
ZINC; EIOACCUBULATIOB; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCOBIUB; ELEMENTS
a) Normal healthy men
h) Chrovium platiaq worker
c) Chro«ate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONSS;
HBPB SODES; 51SCEEIS; SPLEEH;
S10BACH; THYPOID GLANDS; TRACHEA;
ALOBINUB: BARIUM; CADBIUB; CALCIOB;
CHROBIUB; COBALT; COPPER; IRON; LEAD:
HAGNESIOS; MANGANESE: METALS:
POLYBDENOH; NICKEL; PHOSPHORUS;
ECTASSIOB; SILICON; SILVER; SODIUM;
S1RONTIOB; TIN; TITANIOB; VANADIUM;
ZIHC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIECONIUB; ELEMENTS
REFERENCE
Harrison, 5.H.
Zeisler, R.
Vise, S.A.
1981
EPA 600/31-81-025, 6
Pf-
Teraoka, R.
1981
Archives of
Environmental Health
36 (»): 155-165
Teraoka, H.
mi
Archives of
36(«) : 155-165
1
-------
Aluminum
1129-90-5
Al
AtH 26.98150, HP 660 C, BP 2327 C, VP 1 urn Hq at 1540 C
(CONTINUED)
TISSUE
6038
Pancreas
6039
Spleen
6040
Stomach
EXPOSURE ROUTE
ANALYTICAL
BETHOD
BS
ES
ES
NCBBES
OF CASES
5
a) 9
b) 2
c) 3
d| 1
e) 1
10
EA11GE
Not given
a) Not given
b) 8.0-100 ppi
c) 10-48 ppm
d) Hot applicable
e) Hot applicable
Dry »t
Hot given
.
BEAD
t5 *or- 6.2 dry wt
.
a) 22 +or- 18 ppm
b) 54 ppm
c) 23 ppm
d) 52 ppm
e) 520 ppm
Dry wt
26 +or- 16 ppm dry wt
GENERAL INFORBATION
Normal tissue
Autopsies
JAPAN; ADDLIS; AUTOPSIES; ADREBAL
GIANDS; AOSTA; BONES; HEART;
INTESTINES: KIDNEYS; LIVES; LUNGS;
IYBPH BODES; PAHCEEAS; SPIEEH;
STOBACH; THYROID GLANDS; TEACBEA;
ALUBIHDB; BiBIUfl; CADHIUH; CALCIUM;
CHROHIUM; COBALT; COPPER; IROH; LEAD;
BAGHESIDH; ItAHGAHESE; RETALS;
BOLYBDE8UB; HICKEL; PHOSPBOEOS;
POTASSIOB; SILICON; SIIVEB: SODIUB;
S1EOHTIU8; TI»; TITAKIOB; VAHADIUB;
ZIBC; BIOACCDBULATIOH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; 2IRCONIUB; ELEHEBTS
a) normal healthy men
b) Chromium plating workers
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; ADTOPSIES; ADREHAL
GLANDS; AOBTA; BOBES; BESET;
IBTESTINES; KIDHEIS; LIVES; LOHGS;
LYBPR BODES; PANCREAS; SPLEED;
STOBACH; THYROID GLANDS; TBACHZA:
ALOHIH0B; BiRIOB; CADBIUH; CAI.CIOM;
CBBOBIOB; COBALT; COPPER; IBOH; LEAD;
8AGNESIUB; KANGAHESE; BETA IS;
BOLyBDEBUB; 1IICKEL; PHOSPHOBUS;
POTASSIOB; SILICOB; SILVER; SODIUB;
STBO1IIIUI!; TI»; TITJHI0H; V1NAPIUB;
ZINC; BIOACCOHDL1TIOB; HEALTH
HAZARDS; OCCUPATIOM AL HAZARDS;
TONGUE; ZIBCOBIDB; ELEBENTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBEBAL
GLANDS; AOBTA: BONES; HEART;
INTESTIBES; KIDNEYS; LIVER; LONGS;
LTBPH NODES; PANCREAS; SPLIEN;
S10I1ACH: TBYROID GLANDS; TEACHE4:
AlOBIIlUa; BIBIDB; CADfllOH; CJLCIOB;
CBROBIUfl; COBALT; COPPEB; IRON; LEAD;
BAGHESIOH; MANGANESE; BET A IS;
BCITBDEBtIB; BICKEL; PBOSPHCBBS;
EOTASSIOB; SILICON; SILVER; SODIOB ;
STRONTIOH; TIB; TITAHIOB; VANADIUB;
ZINC; BIOACCDBOLATION; HEALTH
HAZARDS; OCCUPATIOSAL HAZARDS;
TCN60E; ZIRCONIOB; ELEHEHTS
.
BEfEREBCE
Teraoka, H-
1981
Archives of
36(4) : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
Teraoka, B.
1981
Archives of
Environmental Health
36 (
-------
Aluminum
7129-90-5
11
AtB 26.9815U, BP 660 C, BP 2327 C, VP 1 II Hg at 1510 C
(CONTINUED)
TISSUE
6041
Thyroid
gland
6042
Tongue
6083
Trachea
EXPOSURE ROUTE
ANALYTICAL
BUTHOD
IS
ES
ES
NOHBER
OF CASES
14
2
2
RANGE
Mot given
.
Hot givea
Not given
11 tor- 3.3 ppm dry
»t
3.0 *or- 8.5 ppro dry
wt
26 +or- 18 ppm dry wt
GENERAL INFORMATION
Normal tissue
Autopsies
Japan
JAPAN: ADOLTS; AUTOPSIES; ADRENAL
BLASTS; JOSTA; BOSES; BEABT;
INTESTINES; KIDNEYS; LIVER; LONGS;
lYBPH BODES; PANCREAS; SPUES;
STOHACH; TBIROID GLANDS; TB1CHKA;
ALOIIINUn; BAGIOI; CADHIUn; CALCIOn;
CBROHIDB; COBALT; COPPER; IRON; LEAD;
BAGNESIOK; BiNGANESE; BETALS;
BCLYBDENUB; NICKEL; PHOSPHORUS:
ECTASSI0B; SILICON; SILVER; SODIOB;
STBOHTIOB; TIN; TITANI0H; VAHADIOH;
ZINC; BIOACCDBULATION; HEALTH
H1ZABDS; OCCUPATIONAL HAZARDS;
TCNGUE; ZIRCONIUH; ELEBENTS
Noraal tissue
Autopsies
Japan
JAPAN; ADOLTS; AOTOPSIES; ADBENAL
GIANDS; AOBTA; BONES; BEAET;
INTESTINES; KIDNEYS; LIVER; LUNGS;
llttPH BODES; FlKCSEiS; SPLEES;
STOITACH; THIROID GLANDS; TBACHEH;
ALDBINOB; BJBIOB; CADHIUBJ CALCIUB:
CBROBinn; COBALt; COPPER; IRON; LEAD;
BAGNESIDB; H1NGANE5E; DETALS;
BOLYBDENUH; NICKIL; tHOSPHOBOS;
EOTASSIOB; SILICON; SILVER; SODIBB;
STROHTIUB; TIN; TITANIDB; VANADIDfl;
ZIHC; BIOACCOBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIOB; ELEBENTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AOTOPSIES; ADBENAL
GLANDS; AORTA: BONES; HEART;
INTESTINES; KIDNEYS; LIVEB; LUNGS;
LY!"PH NODES; PANCREAS; SPLEEN;
STOBACH; THYBOID GLANDS; TBACHEA;
ALDHIBDB; BARIUM; CATBIUfl; CAICIOB;
CEROBIUB; COBALT; COPPER; ISDN; LEAD;
HAGNESIHB; DANGANESE; BETALS;
POLYBDEBUB; NICKEL: PHOSPHORUS;
FOTASSIUH; SILICON; SILVBB; SODIUH;
STBONTIUB; TIN; TITANIUB; VANADIUB;
ZINC; BIOACCDHULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZAEDS;
TCNGUE; ZIRCOHIUH; ELEHENTS
Teraokap H.
1981
Archives of
Environmental
36(»):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
-------
TISSDF
6041*
Adipose
60»5
Liver
ntimony
1110-36-0
EXPOSURE POD1E
ANALYTICAL
METHOD
HPLC
HPLC
NOBBED
OF CASES
10
6
_.
BANGS ( BEAU
!
1
Not detected-575 ppt wet ) 270 ppt wet wt
«t ',
1
1
1
1
1
i
1
110-21(0 ppt wet »t | 173 ppt wet wt
1
1
1
1
1
|
1
1
/
GENERAL INFORBATICB
Autopsies
27-66 yr olds, Japan
INDDSTEIAl CBEBICALS; JAPAN;
AOTOPSIES; ADIPOSE TISSUE; LIVER:
Autopsies
27-66 yr olds* Japan
INDUSTRIAL CHEBICALS; JAPAK;
AUTOPSIES; ADIPOSE TISSOE; LIVES;
PCPOLATION EXPOSURE
REFERENCE
Otana, H.
Hori, S.
KashiBOto, T.
Sunita, ».
198!
Bulletin of
Contaainatioa and
Toxicology 27:23-27
Ofcana, H.
Hori, S.
Kashiaoto, T.
Kunita. ».
1981
Bulletin of
Toxicology 27:23-27
SI
AtS 121.75, HP 630 C, BP 1635 C, VP 1 mm Hg at 886 C, 10 «n Hg at 960 C
TISSOE
60116
Bone
60K7
Ha it
_.
60D8
Hair
EXPOSUHE BOHTE
ANALYTICAL
HETHOD
NA
Hi
NA
N OB BEE
OF CASES
a) 7
b| 5
.
56
5»
&ANGE
a) <0. 02-0. 58 fpm
b) 0.007-0.1 ppm
0.05X10 (E-6) -80.69X10 (E-6
) g/cu cm
160-UOO ng/g
BEAN
a) 0.015 ppn
b) 0.007 ppm
Medians
0.57X10 (E-6) g/cu c«
Not given
GEiiEKAL IBPOBBATION
a) Exposed gcoup
t) controls
Autopsies, fe»ur
45-75 yr old factory workers, Sweden.
Controls froB unpolluted areas
AKTIBONT; AESENIC; CADBIOB; COPPEE;
LEAD; BERCOSY: SILEHlnB; SILVER; TIN;
ZINC; BIOACCdBULATION: IKDOSTEIAL
ATMOSPHERES; IBDOSTBUL PLANTS;
ECPOLATION EXPOSOEE; SBELTEES; BONES;
FEBOR; COHPAEATIVE EVALDATIOSS;
SBEDEN; AUTOPSIES; OCCUPATIONAL
HAZARDS; BETALS
3 CB segaents of single hairs
Sooe saaples below detection lildts
IRIDIUB; BAIR; FORENSIC BEDICINE;
BEASUREBENT SETHODS ; UTIBONI;
ARSENIC: BBOBIHE; COPPER; SOLD;
LANTHANDB; HANGAIESE: BEECORT;
BETALS; SEIEBIOB; SILVER; SODIDB;
ElEONTIOB; ZINC; INDUSTRIAL
ATBOSPHERES
Range of Beans, estiBated froa graph
Aswan, El Kharga, Assait, Cairo, and
Alexandria, Egypt
EGYPT; BATE: SAILS; ANTIBONJ:
CADBIOB; CESIOB; CBBOHIOB; COEiLT;
IEOH; BANGAHESE; BETALS; BOLYBDEHDB;
SCSHDIOB: SILENIOB: SILVEE; TUNGSTEN;
ZIHC; DEIHSISG SITES', EOPOLITIO8
EIPOSOEE; SOILS; OSBAN AREAS
(NEXT PAGE!
Lindh, a.
Bruoe, D.
Nordberg, C.
Wester, P.-0.
1980
Science of the Total
EnvironBent 16:109-116
Dybczynski, R.
Boboli, K.
1976
Journal of
Eadioanalytical
Chesistry 31:267-289
Rasperek, K.
lyengar, G.V.
Feinendegen, L.E.
Hashish, S.
Bahfouz, B.
1982
Science of the Total
Environient 22:1119-168
-------
Antimony
•/14110-36-0
St
itti 121.75, BP 630 C, BP 1635 C, VP 1 am Hg at 866 C, 10 m» Hg at 960 C
(CONTINUED)
TISSUE
60H9
Hair
6050
liver
Mail
EXPOSOPE ROUTS
ANALYTICAL
METHOD
HA
NA
NUMBER
O? CASES
30
RANGE
a) 0.03-1.63 ppm
b) 0.05-0.42 ppm
c) 0.02-1.16 ppm
0.01 ug/g
net »t
HEAN
a] 0. 18 *or- 0.21 ppm
b) 0.2 tor- 0.12 ppm
c) 0.3 +or- 0.3 ppm
Not given
GENERAL ISFORBATICN
a) 12 CD length, 102 samples
b) Root section, 18 samples
c) Distal section, 18 samples
Metropolitan Bombay, India
INDIA; ADOLESCENTS: ADULTS; HilB;
ASTIHOSY; ABSEiriC: BROfllHE; CADHTDS;
CBIQRIBB: CHBOBioH; COBALT; COPPER;
GOLD; IODISE; IRON; LANTHABDB;
«»»GASESE; POTASSIOB; SCASDIOB;
SElENIDn; SILVER; SODIUIt; ZII1C; HE
EOHOTION; BIOACCOnOLATION; FOSSIL
FUELED POBEE PL»»TS; IBDOSTRIAL
AEEAS; IdDOSTEIAL 1TBOSPHEEES ;
I8DOSTRIAL BBISSIO»S; IHDBSTEIAl
POLLUTION; POPDLATIOd SIPOSOBF; OEBAN
AEEAS; INDDStEIAL CHEHICALS
Category 2 as proposed by
International workshop on Monitoring
Environmental Materials and Specimen
Banking (non-pollutant trace element
Autopsies, Baltimore, MD,
Minneapolis, HN, and Seattle, HA
BSRILAND: BIIISESOTA; WASHINGTOS;
10TOPSIES; IIVEB; HEASOBEBEMT
HETHODS; ALOnlBDB; ABTIBOBY; ARSEHIC;
EAEIIIB; CADHIUH; CHEOHIHII; COBA1T;
COPPEB; FLUORINE; IRON; LEAD;
HASGAHESE; aEECUET; HOLTBDESOB;
NICKEL; RUBIDIUM; SELEBIUB; SILVER;
S1RONTIUB; THALLIOB; TIB; VABADIUB ;
IIBC; EOPULATIOS EXPOSURE
Aswan, El Kharga, Assait, Cairo, and
Alexandria, Egypt
EGYPT; HAIR; NAILS; ABTIBOBY;
CADBIUB; CESIUfl; CHBOHIOB; COBALT;
IEOB; BASGA8ESE; BETALS; BOLYBDENUB;
SCABDIOB; SELEBIDB; SILVER; TDBGSTEB;
ZINC; DUNKING BATEE; POPOIATIOH
EXPOSURE; SOILS; DBBAN AREAS
BEFEREBCE
Bhat, S.R.
Arunachalafl, J.
5.
Gangadharan, S.
1982
Science of the Total
Environment 22:169-178
Harrison, S.H.
Zeisler, E.
aise, S.A.
1981
EPA 600/S1-81-025, 6
PP.
Kasperefc, K.
lyengar, G. V.
Feinendegen, L.E.
Hashish, S.
Bahfouz, H.
1982
Science of the Total
Environment 22:119-168
Arochlor 1218
12672-29-6
Exact composition unknown or undetermined
TISSUE
60 '52
Adipose
ETPOSDKE EOUTE
ANALYTICAL
METHOD
GC
HUBBES
OF CASES
26
EANGE
a) 5-234 pp»
b) 2-271 ppm
HEAB
a) 36 ppm
b) 2<4 ppm
Median
GF.SERAL IBFOBSATION 1 REFERENCE 1
1 i
1 i
a) Packed column gas chromatography, | Hclff, B.S. J
son of peak areas ! Thornton, J. <
b) High resolution gas i Fischbein, A. \
chromatography, sun of individual ! Lilis, S. 1
peaks - Selikoff, I.J. J
lotal of peaks with retention time : *982 I
less than p,p*-DDE i Tcxicology and Applied 1
, Pharmacology 62:29»-J06 I
JCIPOSE TISSUE; BLOOD PLASBA; | i
fOIYCHLOKISATED EIPHEHYLS; 1 S
OCCUPATIONSI. HAZARDS: INDUSTRIES '
_ ! i
(NEXT PAGE)
-------
Arochlor 12U8
12672-29-6
Exact composition unknown or undeternined
EXPOSURE POOTE
6053
Blood,
plasma
(CONTINUED)
ANALYTICAL
METHOD
GC
NUBBER
OP CASES
26
BANGS
a) 18-1362 ppb
b) 2-l»12 ppb
HEA»
a} 145 ppb
b) 83 ppb
Median
GENEBAL INFOEBATICS
a) Packed column gas chromatography,
sun o£ peak areas
b) *!igh resoluticn gas
chromatography, SUB of individual
peaks
less than p,p'-DDE
ADIPOSE TISSUE; BLOOD PLASNA;
fOIYCHLOBINATED EIPBBNYLS:
OCCUPATION*! B1Z4BDS; IHDOSTEIES
R
Wolff, B
Thornton
Pischbei
lilis, B
Sellkoff
Toxicolo
Pharnaco
REFEEEHCE
Atcchlor 125i(
11097-69-1
EIACT COMPOSITION OSKHOWH OK OBCETEBHIBED
TISSDE
605D
60 55
plasoa
1
1
EXPOSDBE BOOTE
ABALTTICAL
SETHOD
GC
GC
SUflBEB
OP CASES
26
26
EANGE
a) 2-54 ppo
a) 1-180 ppb
BEAN •
a) 1<4 ppo
aedlan
a) 33 ppb
Heaian
GEHIBAL IBPOBBATICH
a) Packed colUBii gas chroftatography.
b) High resoltttion gas
chronatoqraphy, SUB of individual
peaks
SUB of peaks with retention tiBe
greater than p,p'-DDE
clinical health survey
ADIPOSE TISSOE; BLOOD PLASHA;
FOITCBLOBIHATED EIPHEKIIS;
CCCOPATIONAL HAZABDS; INDUSTRIES
a) Packed column gas chroBatography,
b) High resolaticn gas
chroaatograpliy» sam of individual
peaks
Sui of peaks with retention tiBe
greater than p,pf-DDE
clinical health survey
AEIPOSI TISSOE; BLOOD PLASBl;
fOUCBLOBIBATED BIPBESlLS:
OCCOPATIOBAL HAZABDS; IHDOSTBIES
BETEEENCE 1
1
._.
Wolff, B.S.
Fischbein, A.
Lilis, E.
Sellkoff, I.J.
1962
Toxicology and Applied
Kolff, B.S.
Fischbein, A.
Lilis, B.
Seiikoff, I.J.
1982
Toxicology and Applied
-------
Arsenenous acid, sodium salt
7784-46-5
»s-B-02.Sa
R« 129.91
rsenic
410-38-2
5
tv 7H.9216, ne 817 C at 28 atn , BP 613 C (sublimes), VP 1 >u Bg at 380 C, 10 mm Hg at 410 c
60*6
fjrine
EXPOSUEE POOTE
Ingestion
ANALYTICAL
METHOD
II OH BEE
Of CASES
a) 3
b| 5
a) Not given
b) Hot given
a) 253.9 ug
b) 272.5 ug
GENEBAL INFOBBATIOH
a) 4 day output after 500 ug dose
(25* inorganic arsenic, 21.3%
nonomethylarsonate and 53.7X
dinethylarsinate)
b) 4 day output after 500 ug dose
(after treatment vith lipotropic
agents)(22.6* inorganic arsenic,
14.5* monomethylarsonate, and 62.9%
dimethylarsinate
Healthy 27-42 yr olds
ADULTS; DEINE; COBPAEATIVE
EVALUATIONS; 1B5ENIC; 4ESEHIC OBGASIC
COBPOOHDSi flETABOLITBS
Buchet, J.P.
Lauwerys, B.
Eoels, H.
1981
International Archives
of Occupational and
Environmental Healtfl
48:71-79
TISSOE
6057
Bloor!
6058
Bone
BXEOSOFE EOOTE
Ingestion
ASillTICSL
BETHOD
»A
NiniBEB
OF CASES
a) 1
b| 1 c) 1
al 7
b) 5
E1SGE
a) 4U7-7 ug/1
b) 785-7 ug/1
c) 190-7 ug/1
a) 0.006-0.21 pp»
b) <0. 005-0. 007 ppm
HEJLII
a) Not given
b] Not given
c) Not given
a) 0.014 ppo
b) Not given
Median
GSHEBAL IHFOBBATICN
a) 44 yr old ean, 1 and 25 days after
>1000 ug
b) 40 yr old vonan, 1 and 17 days
after >1000 mg
c) 1 1 yr old girl, 1 and 7 days after
>500 »g
Ate pudding oistakenly made with
AE203
PAL, 2.5-4 »g/kg IB given every 8 hr
for 21 days (a), 17 days (b) , and 9
days (c)
Diarrhea, dehydration, renal
insufficiency, shock, delayed
neuropathy
ACOLTE; CASE HISTOEIES; CHILDEEN;
ELOOD; CEBEEBOSPI81L FLOID ; 08I8E;
ARSENIC; POOD CONTABINATION ;
BETiBOL!SH; HETABOLITES
a) Exposed group
t) Controls
Autopsies, femur
45-75 yr old factory workers, Sweden.
Controls fron unpolluted area.
ANTIBONy; ABSENIC; CADfllOB! COPPEB;
tEAD; BEBCOEJ; SELENItlfl; SILVEB; TIN;
?I»C; BTOACCD!!nl.ATIOS: INDOSIBIAl
ATBOSPBEEES; INDOSTEIA1 PLANTS;
POPULATION EIPOSOEE; SBELTEES; BOHES;
FETOB; COBPAEITI1E E«IH! ATIONS;
SSEDEN; AOTOPSIES; OCCOPATIONAL
BIZAEDS; BIIALS
BEEEBENCE
flanieu, P.
Buchet, J.P.
Eoels, H.A.
Lauwerys, B.
1961
clinical Toxicology
18(9) : 1067-1075
Lindh, 0.
Brune, D.
Nordberg, G.
Hester, P.-O.
1980
Science of the Total
Environment 16:109-116
(NEXT PAGE)
-------
Arsenic
7440-38-2
HE
AtW 714.9216, BP 817 c at 28 at», BP 613 C (sublmes). If 1 » Hg at 380 C, 10 lu H1000 K9
44 yr old
Diarrhea, dehydration, renal
insufficiency, shock, delayed
neuropathy
ACH1TS; CJSS HISTOEIES; CHILDREN;
BICOD; CEREEFOSPINAl FLOID; OEIBE;
AESENIC; FOOD CONT»BIN»TIO»;
HETABOLISH; METABOIITES
Bange of neans, 5 localities
Residents of Iceland
ADULTS; HAIR; ARSENIC; CADHIOM;
BERCURT; nSTALS; SELESHJB; ZINC
a) Current levels for head, pubic and
axillary hair. Exposed to
contaminated food in 1943, developed
b) Noiials
CASE HISTORIES; NEOPLASHS; SKID
IISEASES; HAIE; SKIS; ARSENIC; HETALS
Bcnaparte, 1.3-2,1 CB long, cut
October 16, 1816
b) Segnental (3 BB) analysis of one
high exposure over period of growth
(2 10)
c) Segmental (3 an) analysis of 60 >n
hair froB habitual usec of
d) Segaeotal (3 BB> analysis of 39 no
hair fron atteapted suicide
Reports of deteriorating health of
iugestion
ADULTS; SUICIDE: BETAL POISONING:
HAIR; COHPARATI7E EVALDATICNS;
FOSESSIC SEEICUE; ASSES 1C; HE1J1S
Sone sanples belov detection liBits
ISIDIUn; HAIE; FOBEHSIC HEDICINE;
BEASUEEI!E»T HETHODS ; ABTIH01IT;
AESENIC; BSOfllHE; COPPEB; GOLD;
IJtTHlNOB; dAKSlKESE; KEBCOSY;
HETALS; SELENI0B; SIL7ER; SODIUB;
SJBONTIUB: ZIHC; IBDOSTRIAI
AIBOSPHEEES
REFERENCE
nahieu, P.
Buchet, J.P.
Eoels, H.A.
1981
18(9) : 1067-1075
Johannesson, T.
Lunde, G.
Steinnes, E.
1981
Acta Pharaacologica et
Toxicologica 48:185-189
Renuick, J.H.
Harrington, J. H.
Waldron, H.A.
Dissanaike, D. s.
Lenihan, J.n.A.
1981
Journal of the Society
of Occupational
nedicine 31:144-147
Leslie, A.C.D.
Snith, H.
1978
Archives of Toxicology
41:163-167
Dvbczynski, E.
Boboli, K.
1976
Journal of
Radioanalytical
Chemistry 31:267-289
(NEXT PAGE)
00
-------
Arsenic
•7U40-38-2
,s
tw 71.9216, BP 817 c at 28 atn , BP 613 C (subliies) , VP 1 •» flg at 380 c, 10 urn Hg at
-------
Arsenic
7440-38-2
As
At» 74.9216, HP 817 c at 28 atm, BP 613 C (sublises) , VP 1 »a Hg at 380 c, 10 urn Hg at 140 C
(CONTINUED)
TISSUE
6067
Urine
6068
Urine
EXPOSUBE FOUTE
Ingestion
ANALYTICAL
HETHOD
AA5
HUHBER
OF CASES
a) 1
b) 1
B4BGE
a) Hot applicable
b) Hot applicable
applica
a) Hot given
b) Hot given
c) Nat given
d) Hot given
e\ Not given
f) Sot given
g) Hot given
h) Hot given
I) Not given
BEAD
a) 129 >g
b) 73 «g
a) 198 ug/1
b) 197 1000 ig, 10 «g/24 hr day 3-7
aftec >1000 «g, 16.7 «g/2H hr day 1
c) 11 yr old girl, 8 day total after
>500 ig, 9 ig/2« hr on day 1
Ate pudding aistakenly nade vith
AS203
EAL, 2.5-1 «g/kg IB given every 8 hr
for 21 days (a), 17 days (b) , and 9
days (c)
Primarily inorganic As excreted day
2-4, followed by progressive increase
in organic letabolites to >95J after
day 9
Menbers of sane fanily
Diarrhea, dehydration, renal
neuropathy
AtOLTSj C1SB HISTORIES; CHI1DBEB;
BLOOD; CEREEHOSPIHAL FLUID ; DEI1IB;
ABSEHIC; FOOD COHTABIHATIOH ;
BBTABOLISH; BETABOLITES
a) 1970
b) 1971
C) 1972
d) 1973
e) 1974
f) 1975
g) 1976
h) 1977
i) 1978
Exposure control progran begun
1975-77
shift, breathing zone air.
ncndetectable-5310 ug/cu • (Bean 154
og/ca »)
production facility
OEIHI; AESENIC; ilB POLIOTIOH;
IHDOSTRIll IREAS; IlDOSTIItl
ATItOSPHESES; INDOSTEUL EHISSIOHS;
IHDOSTEIAL POLLOTIOS; SHELTERS
REFEBEHCE
nahieu, P.
Buchet, J,P.
Lauwerys, B.
1981
Clinical Toxicology
18(9) : 1067-1075
Cant, S.fl.
Legendre, L.&.
1982
American Industrial
Hygiene Association
Journal 43:223-226
-------
Arsenic oxide [AE203]
1327-53-3
AS2-03
BH 197.82, SP 313 c (claudetite), 275 C (arseuolite)
TISSUE
6069
Blood,
whole
6070
urine
EXPOSURE ROUTE
Ingestion
Ingestion
ANALYTICAL
BETHOD
NUBBER
OF CASES
1
1
DANCE
7-2 ug/dl
560-40 ug/1
MEAN
Not applicable
Not applicable
GEBIP.AL INDORSATION
5 and 18.5 hr after accidential
ingestion of 9-11 ng. chelation
therapy initiated 5 hr after
exposure.
16 no old
Initial synctons: voaiting, diarrhea.
sinus tachycardia
CASE HISTORIES; CHILDREN; BETAL
POISONING; BLOOD; URINE; DRUG
THERAPY; ARSENIC; INSECTICIDES;
HEALTH HAZARDS
About 18 hr and 6 days after
accidential ingestion of 9-11 Bg.
chelation therapy initiated 5 hr
after exposure.
16 no old
Initial syictoms: voaiting, diarrhea.
sinus tachycardia
CASE HISTORIES; CHILDREN; BETAL
POISONING; BLOOD; URINE; DRUG
THERAPY: ARSENIC; INSECTICIDES:
HEALTH HAZARDS
REFERENCE
Watson. H.D.
Teltri, J,c.
Betcalf, T.J.
1981
Veterinary and Huian
Toxicology
23(3) : 161-166
Watson, W.D.
feltri, J.C.
Betcalf, T.J.
1981
Toxicology
23(3): 161-166
Arsine oxide, hydroxydinethyl-, sodium salt (8 CI)
Arsinic acid, dinethyl-, sodium salt (9 CI)
121-65-2
C2-H7-As-02.Na
B» 214.02, BE 82-86 C, also reported as 60 C and 200 c
TISSUE
6071
Urine
EXPOSURE ROUTE
Ingestion
ANALYTICAL
HETHOD
AAS
BOBBER
OF CASES
1
BADGE
Not given
BEAN
375.7 ug
GENERAL INFORBATION
0-96 hr total output, after 500 ug
dcse. 01 inorganic arsenic, 0?
•ononethylarsonate, and 1001
dimethylarsinate
Healthy 27-12 yr olds
ADULTS; URINE: COBPARATIVE
EVALUATIONS; ARSENIC; ARSENIC ORGANIC
COBPOUNDS; BETABOLITES
PEPERENCE
_
Buchet, J.P.
Lauwerys, R.
Boels, H.
1981
International Archives
of Occupational and
18:71-79
-------
asbestos
1332-21-0
EXACT COMPOSITION ONKSOBN OS ONDETERHINED
TISSUE
6072
lung
6073
Lung
6071
Lung
EXPOSUKE EODTE
Inhalati on
Inhalation
ANSLITICSL
BETHOD
Microscopy
EB
N OH BEE
OF CASES
135
a) 6
b) 6
c) 6
a) 2
b) 2
c) 2
d) 2
e) 1
f> 5
9
BtHGE
a) 1-5 asbestos
bodies/1.5 cu cm
b) 6-10 asbestos
bodies/ 1.5 cu cm
c) 11-20 asbestos
bodies/cu cm
d) > 20 asbestos
bodies/1.5 cu cm
a)
6.8X10(E»1)-1.3X10(E*6)
fibers/cu cm
b)320-7800 fibers/cu cm
c) 51-110 fibers/cu cm
a) 0.1-1 ferruginous
bodies/ml
bodies/ml
c) 0.3-11 ferruginous
bodies/ml
d) 10-6015 ferruginous
bodies/ml
e) 20«000 ferruginous
bodies/ml
f) 0.2-30,193 ferruginous
bodies/ml
g) 0 ferruginous
bodies/ml
MEAN
a) Not given
b) Not given
c) Not given
d) Not given
a) 2XlO(E+6)
ribers/cu cm
b) 2000 fibers/cu cm
c) 100 £ibecs/cu cm
a) Not give
b) Sot give
d) Not give
G) Not gave
f) Not give
g) Not given
GENERAL INFORMATION
.
a) 62 •€ n and 45 women
b) 11 men and 5 women
c) 8 men and 2 women
d) 10 men and 2 women
Number of positive samples for 216
positive cases related to occupation.
Positive association with carcinoma
cf stomach and breast, but not
bronchus
Ncnoccupationally exposed residents
cf East London
UNITED KINGDOM; ADULTS; AGE;
AUTOPSIES; SEX; CARCINQHAS; LONGS;
ASBESTOS; FIBERS; HEALTH HAZARDS;
INDDSTPIAL AREAS; POPULATION
EXPOSURE; SHOKIHG; URBAN ABEAS
a) Rsbestos workers with heavy
exposure (0.5-3** yr) . 25-250 coated
fibers per pleural plaque (5 of 6)
exposure (10-37 yr) . 0-20 coated
fibers per pleural plague (5 oE 6)
coated fibers per pleural plaque ( 1
of 6)
Autopsies
39-73 yr old residents of Le Havre,
France
ADULTS; AUTOPSIES; OCCUPATIONAL
DISEASES; LUNGS; ASBESTOS; FIBERS;
OCCUPATIONAL HAZARDS
b) Automobile workers
c) Asbestos cement plant workers
d) Asbestos textile plant workers
e) Asbestos worker
g) Controls
Specimens obtained by bronchoalveolar
lavage
a) -? ) had suspected or conf irned
4-30 yr exposure.
33-60 yr olds, occupations lly exposed
to asbestos. Controls, 29-65 yr old
volunteers («) or patients with no
brcnchopulmonarv disease (5)
Nuiber of alveolar macrophages
decreased and proportion of
pclymcrphonuclear neutrophiles
subjects had greater lactic
debydrogenase and
S-acetyl-beta-D-glucosaminidase
activities than did controls.
ADULTS; OCCUPATIONAL DISEASES; LONGS;
INDUSTRIAL MEDICINE; LAVAGE;
ASBESTOS; AUTOMOTIVE; PIBEBS; HEALTH
HAZK8DS: OCCUPATIONAL HAZARDS
BEFERENCE
Doniach, I.
S vet ten ban, K.V.
Hathorn, H.K.S,
1975
32:16-30
Sebastieu, P.
Fondimare, A.
Bignon, J.
Honchaux, G.
Desbordes, J.
Bcnnaud, G.
1977
H.H. Halton, (ed.)
Pergamon Press, 435-445
Jaurand, H*C.
Gaudichet , \.
Atassi, K.
Sebastien, P.
Bignon, J.
1980
Bulletin Europeen de
Physiopathologie
Bespiratoire 16:595-606
N>
(NEXT PAGE)
-------
Asbestos
1332-21-H
EXACT COBPCSITION DNKNOBS CR 0NDETERBINED
(CONTINUED)
TISSUE
6075
Respirato
ry
secretion
EXPOSURE ROOTE
ANALYTICAL
HETHOD
NUMBER
OF CASES
176
workers
76
controls
RANGE
a) 30* ferruginous bodies
b) 15-30 ferruginous
bodies
c) 1-t ferruginous bodies
d) 0 ferruginous bodies
MEAN
a) Not given
b) Not given
c) Not given
d) Not given
GENERAL INFOPMATIOH
a) 35* of workers with 5-<16 yr
exposure, 23* of workers with 1-<5 yr
exposure, 3X of workers with <1 yr
exposure, and OX of controls
b) 17% f workers with 5-<16 yr
xposur , H% of workers with <1 yr
xposur , and OX of controls
) 2H% f workers with 5-<16 yr
xposur , i*6< of workers with 1-<5 yr
xposur , 29* of workers with <1 yr
€ xposur , OK of controls
exposure, 12% of workers with l-<5 yr
exposure, and 100t of controls
asbestos exposure, Tyler, TX.
Inmunoglobulin A, cellular atypia,
x-ray abnormalities, rales, and
pulmonary restriction were
significantly different between
TEXAS; ADDLTS; INDUSTRIAL DISEASES;
INDUSTRIAL MEDICIHE; ASBESIOS;
INH&LATIOH; OCCOP A1ION AL HAXAfiDS;
FESPIEATORY SECRETIONS
PEFEBENCE
Nash, D.R.
Fortson , N. G.
Hclarty, J.H.
Hurst, G.A.
1981
and Environmental
Health 7:733-7
-------
Eariui
7UHO-39-3
Ba
AtH 137.3D. (IP 710 C (approx) , BP 1600 C (approx) , VP 10 •• Hg at 1049 C
(CONTINUED)
6077
Aorta
6078
Bone
6079
Bone
EXPOSURE BOOTS
ANALYTICAL
BETHOD
ES
ES
US
NDBBEB
OF CASES
7
5
a) 1
b) 1
cl 1
d) 1
e) 1
f) 1
BJSGE
Not given
Hot given
a) Hot applicable
b) Not applicable
c) Hat applicable
d) Hot applicable
e) Hot applicable
f) Hot applicable
BEAN
<1.3 ppn dry wt
<15 PPM dry wt
a) 12 ppM
b) 11 ppn
c) 1.9 pp»
d) 2.2 ppM
e) 18 ppM
f) 0.85 ppM
Dry wt
GENERAL INFORBATICH
Normal tissue
Autopsies
Japan
JAPAN: ADULTS; AUTOPSIES; ADEENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; IIVER ; LONGS;
1YBPH SODES; PAHCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TBACHEA;
AtOBINOtl; BARIOB; CACBIIIB; CALCIUB;
CBEOBIUH; COBALT; COPPEE; IEON ; LEAD;
BAGNESIDB; HANGAHESE; BETALS;
BCHBDEBDH; HICKIL; PHOSPHOBOS;
ECTASSIUfi; SILICCH; SILVER ; SODIOB ;
SIBOBTIUB; TIN; TITANIUM: VANADIHB;
ZINC; BIOACCUBDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCHG1IE; JIBCOHIUB; ELEB28TS
NorMal tissue
Actopsies
•Japan
JAEAB; ADOLTS; AUTOPSIES; ADEEHAL
GLANDS; AORTA; BOHES; HEART;
INTESTINES; KIDNETSJ LITBE ; LONGS;
1TBPH NODES; PANCREAS; " SPLtEK ;
5TOHACH; THIBOID CLAUDS; TBJCHEJ;
ALCHIHUB; BAEIOIt; CADBIOB; CALCIUB;
CBBOBIUR; COBALT; COPPEB: IBOB; LEAD;
BAGHESIOB; BAHGANESE; HETAI.S;
BCLTBDENUB; NICKEL; PHOSPHCBOS;
ECTASSIUH; SILICOB; SILVER; SODItlfl;
SIKOifTIOd; IIS; TIMMIOB; »»BADIOH;
ZI»C; BIOACC080LATION; HEA1TH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE: ZIRCONIUB; ELEHENT5
a) Bandible, Hauca Hegra site,
recently exposed, pre-cera*ic,
pre-iet»llucqical, date 1500-3000 yr
b) FeMuc, Gaanape ceMetery, speciMeos
exposed on surface 30 yr,
post-ceraMic, pro to-Metallurgical,
date 3000-2500 yr bp
c) Bandible, Hauca Gallinaio site.
Metallurgical, date 2000-1400 yr bp
d) flandible, another person, site c)
e) Bandible, another person, site c)
f) Vertebra, MUMMT of vealthv feMale
Egyptian, PtoleMic period, 2200 yr bp
Ratio of Ba to Ca 2-3J10(E-6) in
present-day Americans
Egypt
EGTPT; PESO: OHITID KIHODOB; UHITED
STATES; BOHES; TBETB; BABtOH;
CAICIUB; LEAD; BICACCUBOLATIOH
SEPEEE»CE
Teraoka, H.
1981
Archives of
Environmental Health
36(1): 155-165
Teraoka, R.
1981
Archives of
36 (»); 155-165
Ericson, J. E.
Shirahata. H.
Patterson, C.C.
1979
New England Journal of
fledicine
300(17) :9»6-951
(8EIT PAGE)
N)
-------
Earlus
7UUO-39-3
Ea
AtW 137.3U, NP 710 C (appro*), BP 1600 C (appror) , VP 10 MI Hg at 10»9 c
(CONTINUED)
TISSOE
6080
Heart
6081
Intestine
6082
Kidney
EXPOSOBE BOOTS
ANALYTICAL
HETHOD
ES
E5
ES
BOH BEE
OF CASES
a) 8
b) 2
c) 3
d) 1
e) 1
10
a) 8
b| 2
c| 3
d) 1
e) 1
BAHGE
a) Hot given
b| <1.3-<1.3 ppm
c) <1.3-<1.3 ppm
d) Hot applicable
e) Not applicable
Dry wt
Not given
a) Not given
bj <1.3-<1.3 ppm
c) <1.3-<1 .3 ppm
d) Hot applicable
e) Hot applicable
Dry wt
BEAN
a) <1.3 ppm
b) <1.3 ppm
c) O • 3 ppm
d) <1.3 ppm
e) <1.3 pp>
Dry wt
<1.3 ppn dry wt
a| <1.3 ppm
b) <1.3 pp»
c) <1.3 ppm
d) <1.3 ppu
e) <1.3 ppm
Dry w t
GESERAL INFORBATICN
a) Hormal healthy men
b) Chromium plating workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEAPT;
ISTESTISES; KIDBEYS; LITER ; LOSGS-,
IYPPH NODES; PAHCBEAS; SPLEEN;
SIOBACH; TBYE01D GLANDS; TBACHEA;
ALOHIN0H; BABIDS; CADBIDB; CALCIUM;
CBBOBIUB; COBALT; COPPEP; IRON; LEAD;
KAGNESIUB; BANGAKESE; HETALS;
BOLTBDENU«; NICKEL; EHOSPHCBUS;
EOTASSIUB; S1LICOH; SILVER; SOD10H;
STBOHTIUS; TIN; TITANIUB; VANADIUB;
ZINC; BTOACCnBULATIOH; HEALTH
HAZABDS; OCCDPATIO»AL HA7.AFDS;
TONGUE; ZIBCONIOB; ELEBENTS
Normal tissue
Autopsies
Japa n
JAIAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEAET;
INTESTINES; KIDNEYS; LITER; LUNGS;
LYBPH NODES; PAHCBEAS; SPLEEN;
STOBACH; THYEOID SLANDS; TEACHEA;
ALCTIHUB; BABIDB; CADBIU1; CALClnB ;
CEBOBIDB; COBALT; COPPER; IROB; LEAD;
BAGBESIDB; BANGAHESE; BETA IS J
HOLY.BDE1HJB; BICKII.; PHOSPHOBOS;
POTASSIDfl; SILICON; SILVER; SODIOB ;
STKOVTIBH: IIH; TITAHIU9; VAKADIUfl;
ZINC; BIOACCDBDLATION; HEALTB
HAZARDS; OCCUPATIONAL BAZAEDS;
TCNGtJE; ZIBCONIUB; ELEflENTS
a) Normal healthy men
b) Chromium plating worters
c) Chromate refining workers
d) Airplane painter
e) stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; BEAST;
INTESTINES; KIDNEYS; LI7EB; LUNGS;
LYPPH NODES; PANCBEAS; SPLEEN;
STOBACH: THYROID GLANDS; TRACHEA;
ALtJBINOB; BARIOS; CADBIOB; CALCIDB;
CBEOMIDB; COBALT; COPPEP; IBOH; LEAD;
HAGNESIUB; KAHGANESE; BETALS;
fCLYBDENOH; HICfCJL; PHOSPBCBOS;
POTASSIUB; SILICON; SILVER: SODIUB :
S1BOSTIUS; TIS; 1ITANIDB; VANADIOB;
ZIHC; BIOACCUBULATION; HEALTH
RAZABDS; OCCUPATIONAL BAZAEDS;
TCNGUE; ZIECCHIUB; ELEBENTS
BEFERENCE
Teraoka, H.
1981
A r ch iv e s o£
Environmental Health
36 (»): 155-165
Teraoka, H.
1981 '
Archives of
36 (K): 155-165
Tecaoka, H.
1981
Archives of
Environmental Health
36(1) : 155-165
_
(NEXT PAC.E)
-------
Barium
•711140-39-3
Ba
«t» 137.31, HP 710 c (appro*) , BP 1600 C (appro*), VP 10 mm Hg at 1049 C
(CONTINUED)
TISSOE
6083
Liver
6081
Liver
6085
Lung
EXPOSUBE ROUTE
ANALYTICAL
METHOD
ES
ES
NUBBER
OF CASES
a) 9
b) 2
c) 3
d) 1
e) 1
30
a) 12
b) 2
c) 3
e) 1
BANGE
a) Not given
b) <1.3-<1.3 ppm
c) <1.3-1.3 ppm
d) Not applicable
e) Not applicable
Dry wt
0.01 ug/g
»et »t
-
a) Not given
b) <1.3-1.5 ppm
c) 1.7-2.6 ppm
e) Not applicable
Dry vt
-
MEAN
a) <1.3 ppm
b) <1.3 ppm
c) Kot given
1) <1.3 ppm
e) 1.6 ppm
Dry wt
Not given
a) 1.6 tor- 0.37 ppm
13) Not given
c) 2. 1 ppm
e) 11 ppm
Dry wt
GENERAL ISFOBBATICN
a) Normal healthy men
b) Chromium plating workers
c] chromate refining workers
Q> Airplane painter
e) stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEABT;
INTESTINES; KIDNEYS; 1IVES ; LUNGS;
LTBPH NODES; PANCBEAS; SPLEEN;
STOBACH; THJROID GLANDS; TBACHEA;
ALCBINUB; BARIUB; CADBIUM; CSLCIUH;
CHROBIUB; COBALT; COPPER! IRON; LEAD;
BAGNESIUB; HANGANESE; HETALS;
BOLTBDENUH; NICKEL; PHOSPHORUS;
EOTASSIDN; SILICON; SILVER; SODIUB;
STRONTIUB; TIN; TITANIOB; VANADIUB;
ZIBC; BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIDB; ELEHENTS
Category 3 as proposed by
International workshop on Bonitoring
Environmental Baterials and Specimen
Banking (trace element of
environmental importance net included
ID first priority list)
Binneapolis, BN, and Seattle, wA
BABILAND; BINNESOTA; WASHINGTON;
AUTOPSIES; LIVER; HEASUREHENT
BETHODS; ALDBINUH; ANTIBONY; ARSENIC;
E1RIUB; CADBIDB; CHBOHIUB; COBALT;
CCPPEB; FLUOBINE; IBON ; LEAD;
BANGANESE; BERCURT; BOITBDENOB;
NICKEL; RUBIDIUH; SELENIOH; SILVER:
S1RONTIUB; TBAILIOH; TIN: VANADIUB;
ZINC; POPULATION EXPOSURE
a) Normal healthy men
b) Chromium plating workers
c) Chromate refining workers
e) stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LDSGS;
ITBPH NODES; PANCREAS; SPLEEN;
STOBACH; TfltBOID GLANDS; TRACHEA;
ALDHINUH; BARIUB; CADHIUB; CALCIUB;
CBROBIUB; COBALT: COPPER: IRON; LEAD;
HAGNESIDB; flANGANESE; HETALS;
POLTBDENDH; NICKEL; PHOSPBOROS;
POTASSIDB; SILICON; SILVER: SODIUH ;
S1SONTIDH; TIN; TIT1NIUH; VANADIUB;
ZINC; BIOACCOIinLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TONGUE; ZIRCOHIUH: ELEHENTS
BEFERENCE 1
Teraoka, H.
1981
Archives of
Environmental Health
36 <»): 155-165
Harrison, S.H.
Zeisler, H.
Wise, S.A.
1981
EPA 600/S 1-81-025, 6
pp.
Teraoka, H.
1981
Archives of
36(»): 155-165
(NEXT PAGE)
-------
Eariuoi
7010-39-3
Ea
AtK 137.3tt, BP 710 c (approi) , BP 1600 C (approx) , VP 10 »• Hg at 1019 C
(CONTINUED)
TISSUE
6086
Lynph
node
6087
6088
Spleen
EXPOSURE fiODTE
ANALYTICAL \ SOHBEE
HETHOD 1
ES
ES
ES
OF CASES
a) 3
b) 1
C) 3
d) 1
e) 1
5
a) 9
b) 2
c) 3
d) 1
el 1
BAHGE
A) Hot given
b> sot applicable
c) 2.0-5.8 ppm
e) not applicable
Dry wt
Hot given
a) Sot given
b) Normal healthy men
b) Chromium elating workers
c) Chromate refining workers
d) Airplane painter
e) stone mason
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADBEHAL
GLANDS; AOfiTA; BOBES; BEAST;
INTESTINES; KIDKEYS; LIVEB; LUNGS;
lYfPH NODES; PANCBEAS; SPLEEN;
STOBACH; THYEOID GLANDS; TBACHEA;
ALtllllNUl": BABIOH; CADHIUB; CAICIOH;
CHEOBIDB; COEALT; COPPER; IBOS; LEJD;
SAGNESHJB; BANGSBESE; BETJLS;
BOLYBDENOB; NICKEL; PHOSPHCROS;
ECTASSIOB; SILICON; SILVER; SODIOB ;
STBOSTIDB; TIB; TITIKIDB; VABADinS;
ZISC; EIOACCUBOLATIOS; HEALTH
HAZARDS; OCCUPATIONAL HAZAEDS;
TCNGUE; ZIRCOBIOB; ELEBENTS
_
BEFERESCE
TeraoXa, H.
1981
Archives of
36(1) :155-165
Teraoka. H.
1981
Archives of
36<«) : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(1) :155-165
(NEXT PAGE)
-------
Bariun
7440-39-3
Ea
At» 137.34, BP 710 c (approx), BP 1600 C (approx) , VP 10 •« Hg at 1049 C
(CONTINUED)
TISSUE
Stomach
6090
Teeth
6091
Thyroid
gland
EXPOSUEE ROUTE
ANALYTICAL
METHOD
MS
ES
NOHBEB
OF CASES
a> 1
b) 1
c) 1
d> 1
4
BANGE
a) Not applicable
b) Not applicable
c) Not applicable
d) Not applicable
Not given
BEAN
.
a) 1.7 pp«
b] 2.9 ppm
c) 1.5 pp»
d) 3. 1 pp«
Dry vt
<1.3 ppm dry »t
SESESAL INFORBATICN
Autopsies
JAPAN; BDOLTS; AOTOPSIES; ADBENAL
GLANDS; AOBTA; BONES; BEABT;
INTESTINES; KIDSEYS; LIVEB; LONGS;
LJHPH NODES; PANCEEAS; SPLEEN;
STOBACH; THYROID GLANDS; TEACBEA;
ALDHIHUH; BARIOH; CADHIOH; CALCIUH;
CBRO1IOB; COBALT; COPPER; IBON ; LEAD;
PAGNESIOB; BANGANESE! BETAIS;
POLYBDENOK; NICKEL; FHOSPHOBOS;
POTASSIOfl; SILICON; SILVEB ; SODIOfl ;
STRONTItln: TIN; TITAWOI!; VANiDIUH;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCOPATIONAL HAZARDS;
TCSGOE; ZIBCONIDB; E1EBENTS
a) Hauca Negra site, recently
exposed, pre-ceranic,
pre-netallurgical, date 4500-3000 yr
before present (fcp)
exposed on surface 30 yr.
post-ceraaic, proto-netallurgical.
date 3000-2500 yr bp
c) Huaca Gallioazo site,
•etallargical, date 2000-HOO yr bp
Enaael
Specilens fro* Viru Valley, Peru
EGYPT; PEED; UNITED KINGDOB; ONITED
STATES; BONES; TEETH; BARIOB;
CAICIOB; LEAD; BIOACCOBOLATION
Normal tissue
Autopsies
Japan
JAPAN; ADOLTS; AOTOPSIES; ADBENAL
GLANDS; AOBTA; BONES; BEABT;
INTESTINES; KIDHEYS-, LIVES; LOBGS;
LYflPB NODES; PANCBEAS; SPLEEN;
STOBACH; TBYBOID GUNDS; TBACHEA:
ALCBIKOB; BABIUB; CADBIOB; CALCIOK;
CBEOBIOB; COBALT; COPPEB; IBON; LEAD;
HAGHESIOB; BANGAHESE; BETALS;
BCLTBDENOB; NICKEL; PHOSPHOBOS;
POTASSIOS; SILICON; SILVEE; SODIOH;
S1BOHTIUH; TIN; TITADIOH; VAH&DITJH;
ZINC; EIOACCUatJLATION; HEAITB
HAZARDS; OCCOPATIONAL HAZAEDS;
TONSOE; ZIBCONIOH; ELE8ENTS
BEFEBENCE
1981
Archives of
36(4) : 155-165
Ericson, J.E.
Shirahata, H.
Patterson, C.C.
1979
Bedicine
300(17) :946-95 1
Teraoka, H.
1981
Archives of
EnvironBeutal Health
36(4): 155-165
(HEXT PAGE)
ro
oo
-------
Eariua
7440-39-3
Ea
AtH 137.3«, BP 710 C (approx) , BP 1600 C (approx) , vp 10 •• Hg at 1049 C
(CONTINUED)
6092
Tongue
6093
Trachea
EXPOSURE EODTE
ANALYTICAL
BETBOD
SOMBER
OF CASES
Not given
<1.3 pp» dry wt
<1,3 ppa dry wt
GENERAL INFORHATICN
Nor»al tissue
Autopsies
Japan
JAFAN: ADDLTS; AOTOPSIES; ADBENAI
GIAHOS; 10BIA; BONES; BEAU;
INTESTINES; KIDNEYS; LIVER; LONGS;
IYBPH BODES; PANCREAS; SPLEEB;
STOBACH; THYROID ELANDS; TRACHEA;
ALOnintm; Btsion; CADHIOH; CALCIOH;
CBROBITH; COBALT; COPPEE; IRON; LEAD;
nAGNESIDt!; OANGAHESE; HETALS;
BCLIBDENOB; NICKEL; PHOSPHOSOS;
POTASSIOB; SILICOK; SILTEB ; SODIOB;
S1BOKTIOB; TIB; TITADIOB; TANADIUB;
ZIHC; BIOACCOHOLATIOH; HEALTH
BJZ1BDS; OCCOPATIONAL HAZARDS;
TCBGOB; ZIBCOSIOB; ELB9E»TS
Noraal tissue
Autopsies
Japan
JAPAN; ADULTS; ADTOPSIES; ADEENAL
GLANDS; AOBIA; BONES; HEAET;
IBTESTIHES; KIDNEYS; LITEE; LONGS;
LYPPH NODES; PANCEEAS; SPLEEN;
SIOBACH; TBYBOID GLANDS; TRACHEA;
ALOBINOB; BABIIIB; CADBIOB; CALCIOB;
CBROBIOB; COBALT; CCPPEE; IRO»; LEAD;
BAGNESIOB; BANGANESE; BETALS;
fCLYBDEHnH; BICKEL: PHOSPHCROS;
EOTASSIDB: SILICON; SILVER: SODIUB;
S1BOBTIOB; TIN; TITAHIOB; VANADIOfl;
ZINC: BIOACCOBOLATION; HEAITB
HAZABDS; OCCUPATIONAL HAZAEDS;
TCNGOE; ZIBCOHIOB; ELEHENTS
Teraoka, H.
1981
Archives of
Environiental Health
36(»|:I55-165
Teraoka, H.
1981
Archives of
Environnental Bealth
36(»):155-165
BEnz (e) acephenanthrylene
205-99-2
C20-B12
H» 252.32, HP 168 C
TISSUE
609(1
Adipose
6095
Liver
EXPOSDBE EOUTE
ANALYTICAL
BETHOD
HPLC
HPLC
BOBBER
OF CASES
10
6
BINGE
56-260 ppt wet wt
33-88 ppt wet wt
HEAN
156 ppt wet wt
68 ppt wet wt
GENERAL INFORBATION
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CHEBICALS; JAP&B;
AUTOPSIES; ADIPOSE TISSUE; LIVER;
Autopsies
27-66 yr olds, Japan
INCUSTF.IAL CBEBICALS; JAPAN;
AUTOPSIES; ADIPOSE TISSUE; LIVEP;
POPULATION 8IPOSURE
REFERENCE
Obana, H.
Hori, S.
KashiBoto, T.
Kanita, N.
1981
Bulletin of
Contamination and
Toxicology 27:23-27
Obana, H.
Bori, S.
Kashiioto, T.
Kunita, N,
1981
Bulletin of
Environnental
Contanination and
Toxicology 27:23-27
-------
Penzene
11-U3-2
C6-H6
HW 78,1lff HP ^,51 rr BP fln 053-80.094
VP 10 na Hq at 26.1 c
I TISSOE
El 00(1
6097
Breath
6098
Breath
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC/HS
Spi ro meter
NOCIBER | HAHGE MEAN i GENERAL INFOS HATICH J REFERENCE
OF CASES
28
117
b) 1. 14-K88 ug/1
c) Not applicable
d) < 0.35-0.42 + or- 0.07
ug/l
e) Not applicable
f) Not applicable
g) Not applicable
h) Hot applicable
2.4-7.5 ng/1
a} 1-26 ug/cu n
b) 0-14 ug/cu a
c) 1.1-18 ug/cu D
d) 2.2-26 ug/cu a
e) 0-14 ug/cu n
f) 0-9 ug/cu m
b) Hot given
c) 186. 6 + or- 1.4
ug/1
d) Not given
e) 0. 28 +or- 0.06
^/l
f) < 0.34 ug/1
ug/1
h) 1.93 tor- 0. 12
ug/1
S.E.
4 ng/1
a) 8.5 +or- 1.5 ug/cu
m
b) 2. 9 *or- O.t8
20 ug/cu a
e) 30 Houston, TX residents, air
levels < 20 ug/cu •
f) 11 Houston, TX residents, air
levels > 20 ug/cu •
Air sampled in individual hoies
Breatb samples 60 1 or 15 iin
breathing tine
Data also by sex, race, habits,
health, diet, drinking water source.
fcad source, age, wt, ht, yr at
present address
Healthy, 20-50 yr old nonsiokers.
nonoccupationally exposed
MISSOURI; TEXAS; AGE; SEX; BLOOD;
URINE; BENZENES; DIETS; DRINKING
HATER; GAS01IHE; INDUSTRIAL
EMISSIONS; OCCUPATIONAL HAZARDS;
POPULATION EXPOSURE; SHORING; BREATH;
INDUSTRIAL CHEHICiLS
Cooper, S.D.
Harris, B.S.H. , III
Hartwell, T.D.
FclsoM, E.,E., Jr.
Pelli2zari, E. D.
Sherdon, A.H.
Wong, T.K.
1980
EPA 560/13-80-028, 194
pp.
_
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, M.P.A.
1977
Journal of
Chroma tographic Science
15:239-244
Zveidinger, H. A.
Cooper, S.D.
Harris, B.S.H. , III
Hartwell, T.D.
Folson, R.E. , Jr .
Pellizzari, E. D.
Sherdon, A. W.
Hong, T.F.
Zelon, H.S.
1980
EPA 560/13-80-028, 194
pp.
(HEM PS6E)
U)
O
-------
Eenzene
71-43-2
C6-H6
BH 79.11, HP 5.51 C, BP 80.093-80.09* C,
VP 10 mm Hg at 26.1 C
(CONTINUED)
TISSUE
6099
Breath
6100
Drine
EXPOSURE BOUTE
ANALlTICAL
SETHOD
Spirometer
NUflBEB
OF CASES
9
3
RANGE
a) 1.1-3.7 ug/cu m
b) Hot applicable
c) Mot applicable
d) Hot applicable
e) 17-27 ug/cu m
£) Hot applicable
g) 6.8-15.0 ug/cu a
h) Hot applicable
i) Hot applicable
a) Hot applicable
b) Hot applicable
c) Hot applicable
d) Hot applicable
e) Sot applicable
MEAN I GENERAL IHFORHITIOH
1
1
1
a) Sot given 1 a) 2 laboratory workers, non-smokers.
cj 7.2 ug/cu 01 I ug/cu n
I) U32 uq/cu 11 | uq/cu a
g) Not given ( c) Filling station attendant,
h) 19 ug/cu a 1 ncn-smoker, workday measurement
i) 58 ug/cu a I d) Non-workday measurement of c) , air
3) 28 ug/cu m I level 13 ug/ca n
I e) 2 filling station attendants.
1 level 19C-260 ug/cu a
1 f) Filling station attendant, smoker,
t direct contact with gasoline.
J Workday measurement , air lerel 153
| ug/cu o
| f ) , air levels 1.1-13 ug/cu •
I h) Shcp vorker, smoker, workday
1 rceasucement , air level 8.2 ug/cil «
I i) Gasoline tanker driver.
t level 51; ug/cu m
j 1) Hon-workday measurement of i) , air
I level 85 ug/cu m
I
| EEEATB; IHDtJSTEUL CHEHICAIS;
| BISSODBI; TEWS; AGE;. SEX; BLOOD;
| ORISE; EESZEHES; DIETS; DEIHKISG
| SAME; GASOtlNE; ISDOSTBIAI
| EBISSIONS; OCCOPATIOHSL HA2AHDS;
| POPULATION EXPOSOEE; 3BO5IKG
I
I
b) 0.93 tor- 0.14 I ug/cu m
ug/1 | bl Filling station attendant, smoker.
d) 2. a +or- 0.4 ug/1 I ug/cu m
e) 1.6 +oc- 0 ug/1 I c) Son-workday measurement ot b) , air
5.E. 1 level 1.« ug/cu m
i d) Gasoline tanker driver.
1 level 54 ug/cu m
i e) Non-workday measurement of d) , air
{ level 85 ug/cu m
1
1 EBEATH; INDUSTRIAL CHEHCAIS:
I B1SSOORI; TEXAS; ASE; SEX; BLOOD:
I URINE; BENZENES; DIETS; DRINKING
I SiTER; GASOLINE; INDUSTRIAL
| tnlSSIOKS; OCCUPATIONAL HAZAEDS;
I POPULATION EXPOSURE; SHORING
1 _ 1 . . .
BE?EBESCB
ZHeidinger, R. A.
Cooper, S.o.
Harris, B.S.H. , III
Hartwell. T.D.
Folsom, E,E., Jr.
Pellizzari, E.D.
Sberdon, A. w.
Wong, T.K,
lelon, H.S.
1980
EPA 560/13-80-028, 19»
PP.
Zweidinger, R.A.
Cooper, S»D.
Harris, B.s.H. , III
Hartnell, T.D.
Folsom, R.E., Jr.
Pellizzari, E. D.
Sherdon, A.W.
Bong, T.K.
Zelon, H.S.
1980
EPA 560/13-80-028, 19»
PP.
-------
Benzene, chloro-
108-90-7
C6-H5-C1
MB 1)2.56, BP -15 C, BP 131.7 C, 7P 10
Hg at 22.2 C
TISSUE
6101
filk
EXPOSURE ROUTE
ANALYTICAL
BETHOD
GC/1S
HUKBER
OF CASES
02
I BJIHGE
a) 0. 1-0.2 ng/ml
b| 0. 1-0.3 ng/ml
c) Trace-0.4 ng/al
d| a. 1-0.3 ng/ml
e) 0. 1-10 ng/«l
f) Trace-10 ng/ol
fl£AB
a) 0. 12 tor- 0. 1
ng/ffll
b) 0.16 tor- 0.039
r.g/nl
c) 0. 12 tor- 0. 11
ng/ml
d) 0. 16 tor- 0.096
ng/ml
e) 1.20 tor- 3.30
ng/ml
f) 0.37 tor- 1.53
ng/ml
GENERAL IHFOBBATIOH
a) Bayonne, NJ, 6 sanples
I) Jersey City, HJ, 5 sanples
c) Pittsbnrgh. P», 12 samples
6) Baton Rouge, LA, 10 sanples
e) Charleston, W7, 9 saiples
f ) Total a) -e)
Due to snail sanple size and
conrandom saopling, data cannot be
extrapolated to entire population
pcllutants in oilk, evaluated using
nilk in pollutant studies near
chemical nanufacturing plants and/or
industrial facilities. Additional
data, U.S. and foreign, relieved.
For additional information contact
Envircnnental Protection Agency,
Exposure Evaluation Division, office
20U61
during preceding wk
ICOISIIHH; »E» JEESEY; PEN HSH.VAHI A;
BEST 7IEGIHIAJ ADULTS; BILK;
BIASDSEBENT METHODS; BESZEHES;
CELOBIBATED HYDEOCiEBOSS ;
CHLOROBE»ZB»ES; EOE; INDDSTRHL
AEE»S; ISDOSTEIAL EBISSIOSS;
1ACTATIOS; PESTICIDE RESIDOBS; OBBAK
AEEAS; INDUSTRIAL CHEBICALS; S01VEHTS
BEFEBEHCE
Erickson, H.D.
Harris, B.S.H., III
Pelliziari, E.D.
Tomer, K.B.
Saddell, B.D.
Whitaker, D.A.
1980
EPA 560/13-80-029, 153
PP-
U)
N3
-------
Benzene, dichloro-
25321-22-6
C6-HU-C12
MS 1H7.01, BP 173-180 C
TISSOE
6102
nilk
EXPOSURE ROUTE
ANALYTICAL
HETHOD
Gc/ns
N On BEE
OF CASES
12
BINGE
a) 0.2-66 ng/ml
b( 0.9-68 ng/Jil
c) 0.2-8.9 ng/ml
d) 0.2-14 ng/ml
e) 0.01-26 ng/ml
f) 0.04-68 ng/ml
BEAN
a) 19.37 tor- 25.54
ng/ml
b) 24.48 «or- 31.69
ng/ml
c) 1.71 *or- 2.41
ng/Bl
d) 8 *or- 13.98 ng/ax
e) 4.30 +or- 8.25
ng/«l
f) 9.15 toe- 17.3
ng/ml
GENERAL IHFORBATION
a) Bayonne, NJ, 6 samples
b) Jersey City, NJ, 5 samples
c) Pittsburgh, PA, 12 samples
d) Baton Rouge, LA, 10 samples
e) Charleston, 91, 9 samples
£) Total a)-e)
Due to small sample size and
nonrandom sampling, data cannot be
extrapolated to entire population
Study measured environmental
pollutants in milk, evaluated using
lilk in pollutant studies vicinity of
chemical manufacturing plants and/or
industrial facilities. Additional
data, 0.5. and foreign, reviewed.
For additional information contact
Environmental Protection Agency,
Exposure Evaluation Division, Office
of Toxic Substances, Washington, DC
20461
lactating volunteers, residing in
during preceding wh.
LOUISIANA; NEB JERSEY; PEKHSYLVANI A ;
BEST VIRGINIA; ADULTS; HILK;
HIASUREKENT BETHODS; BENZENES;
CHLORINATED HYDROCARBONS;
CHLOROBENZENES; DDE; INDUSTRIAL
IBFAS; INDUSTRIAL EfllSSIONS;
LACTATION; PESTICIDE RESIDUES; URBAN
AREAS; INDUSTRIAL CHESICAtS; SOLVENTS
BEfEREHCE
Erickson, M.D.
Harris, B.S.H. , III
Pellizzari, Eo D.
Tomer, K.B.
Waddell, B.D.
whitaker, D.A.
1980
EPA 560/13-80-029, 153
pp.
UJ
LO
Benzene, ethyl-
100-41-U
C8-H10
»» 106.16, .IP -94.97 C, BP 136.25 C, VP 10 mm Hg at 25.9 C
TISSOE
6103
Breath
EXPOSURE BODTE
ANALYTICAL
METHOD
GC/dS
_
NUBEER
OF CASES
28
BANQE
0.6-6 ng/1
HEAN
2.1 ng/1
GENERAL ISFORBATICN
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 14 days before and
during study to minimize number and
ArDLTS; BREATH; AICOHOLS; CHLORINE
ORGANIC COMPOUNDS ; CHLOROBINZENES
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, H.P.A.
1977
Chroaatographic Science
15:239-244
-------
Benzene, hexachloro-
118-74-1
ce-cie
»» 284.80, HP 231 C, BP 323-326 C, VP 1 an Eg at 114.1 C
TISSUE
6104
Adipose
6105
EXPOSURE ROUTE
ANALYTICAL
HETHOD
GC-EC
GC-EC
NUMBER
OF CASES
a) 12
b) 28
c) tO
a) 21
C) 15
RANGE
a) 0.273-1.618 pp«
b) 0.516-1.723 ppm
C) 0.273-1.723 ppm
a) 0.161-10.388 pp»
C) 0. 161-10.388 ppi
BEAN
a) 0.837 tor- 0.360
ppn
b) 1.080 »or- 0.321
ppu
c) 1.007 tor- 0.31(7
PPB
a) 3.735 tor- 0.694
PP«
b) 3.322 »or- 0.528
ppn
c) 3.515 tor- 0.425
ppa
GENERAL INFORMATION
a) Bural residents
b) Urban residents
c) Conbined, rural and urban
residents
Spain
SPAIN; ADIPOSE TISSUE; COMPARATIVE
EVALUATION; CHLORINE COMPOUNDS;
fUNGICIOES; HEXACHIOROBENZENE; HEALTH
HAZARDS; RUHAI AREAS; OFBAS AREAS
a) Rural residents
c) Conbined, rural and urban
residents
Spain
SPAIN; BILK; COMPARATIVE EVALUATIONS;
FUNGICIDES; HEXACHLOROBESZENE; HEALTH
BA2ARDS; POPULATION EXPOSORE; RURAL
APEAS; URBAN AREAS
REFERENCE
PczoLora, B.
Herrera Har tea cite, A.
Polo Villar, L.n.
Jordral villarejo, a.
Hall ol Escobar, J.
Polo Villar, G.
1978
Revista de Sanidad e
Higiene Publica
52(Sept/Oct)
Polo Villar, L.H.
PozoLora, R.
Lopez GimHenez, R.
Jodral Hllarejo, B.
Iglesias Perez, J.
1979
Revista Espanola de
Pediatria
35(207-208) :27 1-2714
1
Eenzene, o-dichloro-> (8 CI)
Benzene, 1,2-dichloro- (9 CI)
95-50-1
C6-H4-C12
li« 147.0, BP -17.5 C, BP 180-183 C, up 1 mn Bg at 20.0 C
U>
6106
Breath
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC/BS
NUBBEE
OF CASES
28
RANGE
0.03-1.2 ng/1
BEAN
0.3 ng/1
GENERAL INFORMATION
Estimated fron graph
Healthy 18-60 yr olds, nonsaokers.
aaount of ezogenous constituents.
ADULTS; BBEATH; ALCOHOLS; CHLORINE
ORGANIC COMPOUNDS; CHLOROBENZENES
BEFERENCE
K cotoszynski, B.
Gabriel, S.
O'Neill, H.
Claudio, B.P. A.
1977
Chroaatographic Science
15:239-21(11
Eenzene, o-diethyl- (8 CI)
Benzene, 1,2-diethyl- (9 CI)
135-01-3
C10-H114
BW 1311.22, MP -31.2 C, BP 183.4 c, VP 1 •• Hg at 22.3 C
6107
Breath
EXPOSURE ROUTE
ANALYTICAL
METHOD
SC/BS
..
NUnBEfi
OF CASES
28
RANSE
0.2-2 ng/1
MEAN
0.65 ng/1
GENERAL INFORMATION
Estinated froa graph
Healthy 18-60 yr olds, nonsaofcers.
Rigid protocol 14 days before and
during study to Einiaize ouaber and
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COMPOUNDS ; , CHLOROBINZESES
REFERENCE
KrotoszynsKi, B.
Gabriel, G.
O'Neill, H.
Claudio, fl.P. „.
1977
Chroaatogcaphic Science
15:239-240
-------
Benzene, p-dichioro- (8 CI)
Benzene, 1,4-dichloro- (9 CI)
106-16-7
C6-H4-C12
«» 117.01, »P 53 C, BP 774.12 C, If 10
Hg at 54.8 C
TISSUE
6108
Breath
EXPOSURE ROUTE
ANALYTICAL
BETBOD
GC/MS
NUflBER
OF CASES
28
BAHGE
0.6-5.7 ng/1
1.8 ng/1
GENERAL IHFORBATICN
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 14 days before and
during study to tinimize number and
alount of exogenous constituents.
JCULTS; BREATH; AICCHOLS; CHLORINE
CEGANIC COMPOUNDS; CHLOR08F.SZENES
REFERENCE
Krotoszynski, 8.
Gabriel, G.
O'Neill, H.
Claudio, a.p.A.
1977
Journal of
Chromatographic science
15:239-244
Eenzidine (8 CI)
(1,1'-Biphenyl) -4,4 '-diamine (9 CI)
92-87-5
CI2-H12-N2
MB 184.23, MJ> 127.5-128.7 C at 740 mi Hg, BP 401.7 C
TISSUE
6109
EXPOSURE ROD1E
ANALYTICAL
HETHOD
GC/MS
NOBBES
OF CASES
5
RANGE
1.0-25.4 umol/»«ol
cceatinine
MEAN
Not given
GENERAL INFORMATION
_
After acid hydrolysis. Ho free
tenzidine or monoacetylbenzidine
found in 200 samples during 15 mo
period
Textile dye workers, England.
INDUSTRIAL CHEMICALS; UNITED KINGDOM;
AEOLTS; OBINE; BENZIDISE;
CCCUPATIONAI HAZARDS
REFERENCE
Meal, P.F.
Cocker, J.
Hilson, H.K.
Gilnour, J.n.
1981
British Journal of
Industrial Bedicine
38:191-193
U>
Ol
Benzilic acid, 4,4l-dichloro-, ethyl ester {8 CI)
Eenzeneacetic acid, 4-chloro-alpha-(U-chlorophenyl)-alpha-hydroxy-, ethyl ester (9 CI)
510-15-6
C16-B14-C12-03
HV 325, BP 148 C at 0.04 mn Hg
TISSUE
_ ^^g
EXPOSURE ROUTE
ANALYTICAL
METHOD
SOMBER
OF CASES
5
RANGE
0.07-6.2 ppm
MEAN
1.3 ppm
GENERAL INFORMATION
Pleasured as p, p ' -dichlorobenzophenone
from oxidation of patent compound and
metabolites, part of data analyzed
in terns of ng creatinine. Exact
exposure level unknown.
Citrus grove workers, Florida
FLORIDA; ADOLTS; URINE; PESTICIDES;
FASHS; OCCTJ E A1I08 &L HAZARDS;
PESTICIDE RESIDUES; RORAL AREAS
REFERENCE
Levy, K.A,
Brady, S.s.
Pfaf fenbecger , C.D.
1961
Bulletin of
Environmental
Contamination and
Toxicology 27:235-238
-------
Eenzo (a) pyrene
50-32-8
C20-H12
BW 252.3, BP 179 c, BP 372 C at 10 mm Hq
TISSOE
6111
Adipose
6112
liver
EXPOSURE ROUTE
ANALYTICAL
METHOD
HPLC
HPLC
NUKBEE
OP CASES
10
6
BANGE
12-59 ppt net wt
10-32 ppt wet wt
BEAN
22 ppt wet wt
18 ppt wet wt
GENERAL ISFOBBATICN
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CHEMICALS; JAPAN;
AUTOPSIES; ADIPOSE TISSUE; LIVEB;
POPULATION EXPOSDBE
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CHEBICALS; JAPAN;
AUTOPSIES; ADIPOSE TISSUE; LIVEB;
REFEBENCE
Obana, H.
Hori, S.
Kashiaoto, T.
Kunita, H.
1981
Bulletin of
Env icon Mental
Contaaination and
Toxicology 27:23-27
Obana, H.
Hori, S.
Kashiaoto, T.
Kunita, N.
1981
Bulletin of
Contaaination and
Toxicology 27:23-27
1
Benzo(e)pycene
192-97-2
C20-H12
BS 252.30, HP 178-179 C
TISSUE
6113
Adipose
EXPOSURE ROUTE
ANALYTICAL
BETHOD
HPLC
NOBBER
OF CASES
10
BANGS
30-150 ppt wet wt
BEAN
80 ppt wet wt
GENERAL INFORBATICN
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CBEBICALS; JAPAN;
AUTOPSIES; ADIPOSE TISSUE; LIVER;
POPULATION EIPOSUBE
REFEBENCE
Obana, H.
Hori, S.
Kashiaoto, T.
Kunita, N.
1981
Bulletin of
Environaental
Contaaination and
Toxicology 27:23-27
Eenzo(ghi)pecylene
191-2H-2
C22-H12
Bit 276.3», HP 277-279 C, BE >500 C
TISSUE
61t«
Adipose
6115
Liver
EIPOSUBE ROUTE
ANALYTICAL
HETHOD
BPLC
HPLC
NDHBEB
OF CASES
10
6
BASSE
13-110 ppt wet wt
17-59 ppt »et wt
BEAN
48 ppt wet wt
38 ppt wet wt
GENEBAL INFOBBATICN
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CHANGES; JAPAN; AUTOPSIES;
ADIPOSE TISSDE: LIVEB; POPULATION
EIPOSURE
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CHBBICSLS; JAPAK;
AUTOPSIES; iDIPOSE TISSOE; LIVEB;
POPOL1TION IIPOSDEE
Obana, H.
Hori, S.
Kashiaoto, T.
KDnita, N.
1981
Bulletin of
Environmental
Contaalnation and
Toxicology 27:23-27
Obana, a.
Hori, S.
Kashimoto, T.
Kunita, N.
1981
Bulletin of
Environmental
Contamination and
Toxicology 27:23-27
-------
Eenzo (k) f luoranthene
207-08-09
C20-H12
BS 252.32, BP 217 C, BP 480 C at 760 »« Hg
TISSUE
61 16
Adipose
6117
liver
EXPOSURE ROD1E
_
ANALYTICAL
BETHOD
HPLC
HPLC
H OH BEE
OF CASES
10
6
BADGE
Not detected-48 ppt wet
wt
6-23 ppt »et wt
SEAN
26 ppt wet wt
13 ppt wet wt
. -
GENERAL INFORHATION
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CHEHICALS; JAPAH;
AUTOPSIES; ADIPOSE TISSUE; LIVEB;
POPULATION EXPOSURE
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CHEBICALS; JAPAN;
AOTOPSIES; ADIPOSE TISSUE; LIVES;
POPULATION EXPOSOBE
BEFEBENCE
Obana, H.
Hori, s.
Kashiioto. T.
Kunita, H.
1981
Bulletin of
Toxicology 27
Obana, H.
Hori, s.
Kashinoto, T.
Kunita, 8.
1981
Bulletin o£
Contamination
Toxicology 27
and
: 23-27
and
:23-27
Benzyl alcoh
1,2-Benzened
51-11-2
:8-H11-»-03
IB 169. 18, »
TISSDE
6118
Blood,
plasma
1, alpha- (aminomethyl) -3,4-dihydroxy-, (-)- (SCI)
ol, U- (2-amino-l-hyclroxyethyl)-, (B|- (9 CI)
191 C (decooip)
EXPOSURE ROUTE
ANALYTICAL
BETHOD
HIIBEES
OF CASES
a) 84
b) 67
C) HI
3) 40
HANGE
a) 130-700 pg/ml
b) 40-650 pg/ml
C) 130-600 pg/«l
d) 170-650 pg/ml
BE AS
a) 304 +oc- 20 pg/ml
b) 339 +or- 23 p3/ml
c) 279 +or- 20 pg/ml
d) 385 *or- 31 pg/ml
GENERAL ISFORBATICN
a) Nornotensive
b) Hypertensive
c) Normotensive, 16-30 yr eld
d) Hypertensive, > 40 yr old
Nean increments on standing for 10
min, a-d, 239, 256, 380 and 279 pg/»l
Nc significant differences in
from graph
JIOLTS; AGI; HYPERTENSION; BLOOD
FLASBA; AUTOHOBIC DBUGS; COHPAEATI7E
EVALUATIONS
REFERENCE
Lake, C.R.
Ziegler, R.G.
Coleian, B.D.
Kopin. I.J.
1977
New England Journal of
Hedicine 296 (
-------
BHC, total (No postings in CHEHLINE).
58-89-9
C6-H6-C16
B« 290.85
TISSUE
6120
Elood
6121
Blood,
fetal
Blood,
serum
EXPOSOBZ BOOTE
ANALYTICAL
BETHOD
GC
GC
N OH BEE
OF CASES
100
100
b| 27
c) 81
d) 68
e) HO
BANGE
a) 8.5-850.0 ppb
b) Hot gi en
c) Not gi en
d) Hot gi eu
e) Not gi en
f) Sot gi en
g) Not gi en
a) 2.0-507.8 ppb
b) Hot gi en
c) Hot gi en
d) Hot gi en
e) Hot gi en
f) Hot gi en
g) Hot gi en
b) Hot given
c) Not given
d) Hot given
e) Not given
f) Not given
g) Not given
i) Not given
j) Not given
MEAN
a) 49.9 *o - 25.6 ppb
b) 43.0 0 - 46.2 ppo
c) 63.7 o - 60.5 ppD
d) 52.4 o - 28.2 ppb
e) 61.3 o- 117.5
PPD
f) 55.0 0-91.0 ppb
g) 60.5 o - 32.6 ppb
a) 43. 1 to - 26.4 ppb
b) 32.9 »o - 125.2
ppb
c) 45.7 *o - 30.6 ppb
d) 38.3 »o - 43.7 ppb
e) 35.6 to - 20.2 ppb
f] 27.0 to - 13.6 ppb
g) 47.3 to - 92.0 ppb
PP»
b) 0. 100 tor- 0.0688
PP»
c) 0.294 tor- 0.2134
PPI"
d) 0.323 tor- 0.1526
e) 0.171 tor- 0.0812
ppn
f) 0.365 tor- 0.1122
ppB
g] 0.449 tor- 0.1257
ppm
h) 0.3SO tor- 0. 1411
PP«
ppB
j) 0.302 tor- 0.1121
GEHEBAL INFORBATICN
a) All subjects
t) 60 subjects, ages 18-25 yr
c) 40 subjects, ages 26-34 yr
d) 42 subjects, vegetarians
e) 58 subjects, non-vegetarians
f) 43 subjects, rural
g) 57 subjects, urban
flaternal blood, collected 8-12 hr
before parturition
Residents of Lucknov, India
INDIA: ADOLTS: AGE; FETUS; BLOOD:
PLACENTA: CHLORINE ORGANIC CCBPCDNDS;
CCt; DDE; DDT; HEXACHLOROCYCLOH tXANE;
LINDANE; PESTICIDES; AGRICULTURE;
BIOACCOBOLATION; DIETS; PREGNANCY;
BUBAL ABEAS; OBBAN ABEAS; PESTICIDE
RESIDUES; POPOLATION BXPOSEBE
a) All subjects
b) 56 subjects. Bother's age 18-25 yr
c) 34 subjects. Bother's age 26-34 yr
d) 36 subjects, vegetarian aethers
e) 54 subjects, non-vegetarian
ncthers
f) 42 subjects, rural
g) 48 subjects, urban
Cord blood, collected at delivery
f) and g) significantly different
INDIA; ADOLTS: AGE; FETOS; BLOOD;
PLACENTA; CHLORINE ORGANIC COflPCONDS;
CtC; DDE; DDT; HEXACHLOROC YCLOHEXANE;
LINDANE: PESTICIDES; AGRICOLTOBE;
BIOACCOBOLATION: DIETS; PREGNANCY;
BOBAL ABEAS: OBBAN ABEAS; PESTICIDE
RESIDOES; POPOLATION EXPOSURE
b) 1 season of prior exposure
e) >3 seasons of prior exposure
f ) Group a) , post-exposure
g) Group b) , post-exposure
i) Group d) , post-exposure
j) Group e) , post-exposure
a)-e) Pre-exposure
f ) - j) After 16 wk spraying technical
grade FCH (3. IK alpha, .7* beta, and
IV gauma) , applied with puap (20
«g/sg ft)
0-4 seasons prior occupational
exposure
ADOLTS; BLOOD SERHH ; CHLORINATED
B1DROCABBQSS; CHIORISS OBGANIC
COSPOONDS: HEIACHLOROClClOHEXJSE;
PESTICIDES; OCCDP»TIO»AL HAZARDS;
PESTICIDE BESIDOES
REFERENCE
Saxena, B.C.
Siddiqui, H.K.J.
Bhargava, A.K.
Krishna Burti, C.R.
Kutty, D.
1981
Archives of Toxicology
48: 127-134
Saxena, B.C.
Siddiqui, B.K.J.
Bhargava, A.K.
Krishna Burti, C.R.
Kutty, D.
1981
Archives of Toxicology
48:127-134
Parikh, J.R.
Shah, K.P.
Chatter jee, S.K.
Kashyap, S. K.
1982
Archives of
37(1) :41-«4
(NEXT CAGE)
U>
00
-------
EHC, total (Ho postings in CSBHLTSE).
?8-89-9
C6-H6-C16
BS 290.65
(CONTINUED)
| TISSUE
Placenta
EXEOSOBE BOOTE
ANALYTICAL
HETHOD
GC
- -
H 08 B£E
OF CASES
100
&AKGE
a) «. 2-390,7 ppb
b) t(ot given
c) Mot given
d) Wot given
e) Not given
f) Hot given
g) Sot given
flEAtf
a) 45, « o - 21.0 ypD
b) 41.8 0-7.0 ppo
c) 50.9 o - 29.3 ppb
d) 38.5 o - 65.1 ppb
e) 52.7 o - 3U.9 ppo
f) 18.0 o - 27.3 ppk
g) 57.7 o - 61.9 ppb
GENERAL INFOBHATICN
a) All subjects
t) 60 subjects, aqes t8-25 yr
c) 10 subjects, ages 26-3U yr
d) 42 subjects, vegetarians
e) 58 subjects, nou-vegctacians
f) t3 subjects, rural
g) 57 subjects, ucban
Tissue collected at delivery
fc) and c) , a> and e) significantly
different
Residents of luck now, India
INDIA; A00LTS; AGE; FETUS; BLOOD;
PLACENTA; CHLOSINF ORGANIC COHPCtJNDS;
CIE; DDE; DDT; HEXACHLOROCYCLOH IXANE;
LINDANE; PESTICIDES; AGBICOLTaRE;
BIOACCDH0LATION; DIETS; PREGSANCY;
PDPAL ABEAS; OEBAM AREAS; PESTICID2
SESIDOES; PGPOLATION EKPOSOBS
REFERENCE
Saxena. , B«C.
Siddiqui, n.K,J.
Bhargava, A.K.
Krishna HUrti, C.H.
Kutty, D.
1981
Archives of Toxicology
<*8:T27-T3 3 ppm
c) > zero
d) * zeio
=• 3 ppm
-- 3 ppm
(NEXT
MEAN
positive
c) Not given
d) Not given
positive
PAiiE)
GENERAL IHFOPHATICH
5.85% were >3 ppm
5,80% were >3 ppm
c) 1974 90.75% were positive,
5.08Z were ->3 ppm
d) 1975 94.ZQ% were positive
10.74% were >3 ppm
9.^9% were >3 ppm
Over study years (1972-76) nonwhltes
than whites for percent PCB > 3 ppm.
from 84 58% (1972) to 96 54% (1976).
Ihe National Human Monitoring Program,
in general US population and assesses
changes all trends. Fr>r more information,
Exposure Evaluation Division, Office of
Toxic Substances, Washington, DC 20460
Autopsies, whites and nonwhltes from
AUTOPSIES; RACIAL STUDIES; ADIPOSE
TISSUE: POT YCHLORINATED BIPHENYLS
_
REFERENCE 1
F-cickson, H.D.
silliaus, S.B.
1980
EP1 560/13-79-015. 101
PF-
'
-------
Eiphenvl, chloro (8 CI)
1, I'-Blphenyl, chloro derivs (9 CI)
1336-36-3
EXACT COBPOSITION UNKNOWN CS UNDETESNISED
(CONTINUED)
TISSUE
6125
Blood
6126
Bilk
EXPOSURE ROUTE
Ingestion
ANALYTICAL
BETHOB
GC
GC/BS
NUB
OF C
a) 23
b) 41
1
NOB BEE
OF CASES
a) 23
b) 41
1
RANGE
a) 1-800 ppb
b) 1-30 ppb
a) 6.6-8.6 ng/g
b) 578-647 ng/g
BEAN
a) 99 »or- 163 ppb
b) 6.7 *or- 5.3 ppb
a) Not givea
b) Not given
GENERAL INFORHATICN
a) Taiwan, 1979-80, fen lonths after
ingestion. 19 cases with levels >10
FF»
b) Japan, 1973, 5 yr after ingestion.
7 cases with levels >10 ppb
Poisoning by contaminated rice oil
Only PCBs with long retention tine
reBaining in b)
TAI9AN; JAPAN; BLOOD; CHLORINATED
HTPROCARBOHS; POirCHlOBISJIBD
EIFHENYLS; EIOACCUHULATION ; FOOD
CCSTAfllBATIOH: POPULATION EXPOSURE;
INDUSTRIAL CJiBHICALS
a) whole lilk
b) fat
Range for 4-6 extraction techniques.
Of total by »t in milk, 9-101 vas
trichlorobiphenyl, 15-28*
tetrachlorobiphenvl , 10-161
pentachlorofciphenyl, 12-15K
hexachlorobiphenyl, 27-49?
heptachlorobiphenyl, ana 7-9K
octachlorobiphenyl
INDDSTEIAL CHEKICU.S; CANADA; ADULTS;
HILK; (lEAStTSEBEBI METHODS; F»TS;
EOITCBIOBIBATED BIPBESyiS
BEFERESCE
nasuda, T.
Kutoki, H.
Yaaaryo, T.
Haraguchi, K.
Kuratsune, N.
Hsu, S.T.
Cheuosphere
11 (2) : 199-206
Hes, J.
Davies, D-J.
Lau, P.-T.
1980
Cheiosphere 9:763-769
Biphenyl, 2,2',4,4'-tetrachloro- (8 CI)
1,1'-Biphenyl, 2,2',4,4<-tetrachloro- (9 CI)
2437-79-8
C12-H6-C14
BS 291.98
TISSUE
6127
Adipose
6128
Blood,
plasma
EXPOSURE ROUTE
ANALYTICAL
BETBOD
GC
GC
NUBBEB
OF CASES
26
26
RINSE
0.09-11 ug/g
0.2-24 ag/ml
0 . 6 ug/g
Bedian
3 ng/»l
Bedian
BEAK
ug/g
ian
g/nl
ian
GENERAL IBFOPBATIOS
Capacitor Manufacture workers. 1976
clinical health survey. Relative
concentrations used to calculate
adipose-plasaa partition
ADIPOSE TISSUE; BLOOD PLASBA;
FCIYCHLOBIHATED EIPHENILS;
OCCUPATIONAL HiZiBBS; INDOSTEIES
clinical health survey. Relative
concentrations used to calculate
adipose-plasaa partition
ADIPOSE TISSUE; BLOOD PLASBJ;
POIYCBLOSIH1TED EIPBBNILS;
OCCUPATIONAL HAZARDS; INDUSTRIES
REFERENCE
Wolff, fl.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
V olf f f fl. S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Phariacology 62:294-306
1 I
-------
Biphenyl, 2,3,', I*,!*'-tetrachloro- (S CI]
1,l'-Biphenyl, 2,3* ,<*,
-------
Biphenyl, 2,3,1,I'-tetrachloro- (8 CI)
l,1'-Biphenyl, 2,3,1,1'-tetrachloro- (9CI)
33025-1(1-1
C12-H6-C11
»W 291.98
TISSUE
61311
Adipose
6135
Blood,
plasma
EXPOSURE ROUTE
ANALYTICAL
HETHOD
sc
.
GC
NOHBE8
OF CASES
26
26
RANGE
.
0.03-6 ug/g
0.7-29 ng/ml
BEAU
0.9 ug/g
Median
3 ng/ml
Mfcdian
GENERAL IHFORBATICN
_
Analytically indistinguishable from
3,1, 3' , 5'-tetcachlarobiphenyl
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ACIPOSE TISSUE; B1OOD PLASBA;
ECIYCHLORINATID EIPHF.NYLS;
OCCUPATIOHAI HAZARDS; INDUSTRIES
Analytically indistinguishable from
3,<», 3' , 5'-tetrachlorobiphenyl
clinical health survey. Relative
adipose-plasna partition
ADIPOSE TISSUE; BLOOD PLASBA;
EOIYCHLORINATED EIPHENYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
REFEBENCE
Wolff, B.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
Wclff, B.S.
Thornton, J.
Fischbein, J.
LiUs, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
iphenyl, 2,3', », H', 5-pentachloro- (8 CI)
,ll-£iphenyl, 2,3',1,I1,5-pentachloro- (9 CI)
31508-00-6
C12-H5-C15
«« 316
TISSUE
6136
Adipose
6137
Blood
6138
Blood,
plasma
EXPOSURE ROUTE
Ingestion
ANALYTICAL
BETHOD
SC
SC
SC
SUHEEB
OF CASES
26
a) 10
b| 9
c) 7
26
BANGE
0.09-5 ug/g
a) Not given
b) Hot given
c) Hot given
.
0.7-11 ng/nl
HEAN
2 ug/g
ledian
a) 3.16 +or- 2.37 ppb
b) 0.13 +or- 0.05 ppb
c) 0.22 *or- 0.09 ppb
8 ng/Bl
Bedian
GEHEBAL IHFOSHATIOS
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ABIPOSE TISSUE; BLOOD PLASBA;
POLYCHLORIHATED EIPHESYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
a) Taiwan, PCB poisoning
b) Japan, PCB poisoning
c) Japan, controls
Few months (a) and 5 yc (b) after
ingesting contaminated rice oil.
TAIWAN; JAPAN; BLOOD; CHLOEINATIO
HYDROCARBONS: PO IYCHLOBINATED
EIPHIBYLS; EIOACCUHUHTION; FOOD
CCNTABISATION; POPULATION EXPOSURE;
ISDOSTSUl CBESICALS
Capacitor manufacture vorkers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
POIYCBLOBINATED EIPHEKYLS;
OCCOPATIOKAL HiZlBDS; IlTDdSTBIES
BEFERENCE
»ol£f, B.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff. I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Basuda, Y.
Kurolii, H.
Yamaryo, T.
Haraguchi, K.
Kuratsune, fl.
Hsu, S.T.
1981
Chemosphere
11 (2) : 199-206
Wolff, B.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
-------
Biphenyl, 2,3',1',5-tetrachloro- (a cl)
1,1'Biphenyl. 2,3",1',5-tetrachloro- (9 CI)
32598-11-1
C12-fl6-cl
C12-H6-C11
»« 29 1.98
TISSOE
61<4 1
adipose
6142
Blood,
plasma
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC
GC
» OH BEE
OF CASES
26
26
EAMSE
0.5-36 ug/g
0.7-180 ng/ml
H£AN
7 ug/g
Median
26 ng/ml
Median
GEBEEAL IHFOE BATICH
clinical health survey. Belative
levels used to calculate
adipose-plasna partition
ADIPOSE TISSOE; BLOOD PLASKA:
PCLYCHLOBIHATED EIPHENYLS;
OCCOPATIOHAL BAZABDS; IHDDSTBIES
_
clinical health survey. Belative
levels used to calculate
adipose-plasaa partition
ADIPOSE TISSOE: BLOOD PLASMA;
POLYCHLOBIHATED BIPHEHYLS;
OCCOPATIONAL HAZABDS; IBDOSTEIES
1
BEFEEEHCE
Bolff, M.S.
Thornton, J.
Fischbein, A.
Lilis, E.
Selikoff, I.J.
1982
Toxicology and Applied
Pharaacology 62:291-306
Bolff, M.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Phariacology 62:291-306
Eiphenyl, 2,0',5-trichloro- (8 CI)
1,1'-Biphenyl, 2,1',5-trichloro- (9 CI)
16606-02-3
C12-P7-C13
MS 257.51
I TISSOE
1
1
I 6113
1 Blood,
1
1
!
1
1
1
1
EXFOSUBE qOOlE
ASALYTICAL
METHOD
GC
HUBBEB
OF CASES
26
KAHGE
1-850 ng/nl
BEAK
27 ng/ll
Mtdian
GEHEBAL IBFOEBATIOS
Analytically indistinguishable fron
2,1,1'-trichlorobiphenyl
clinical health survey
Relative concentrations used to
calculate adipose-plasna partition
ADIPOSE TISSOE; BLOOD PLASBA;
EOIYCHLOBISATED EIPHCTYLS;
CCCOPATIOBAL HAZABDS; INDOSTBIES
EEFEBENCE
Wolff, M.S.
Thornton, J.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Phar»acology 62:291-306
-------
Biphenyl, 3,3* ,4,4'-tetrachloro- (8 CI)
I.l'-Biphenyl, 3,3',4,4'-tetrachloro- (9 CI)
32598-13-3
C12-H6-C14
MW 291.98
TISSUE
F UK
Adipose
6115
Blood,
plasma
EXPOSURE BOOTE
ANALYTICAL
BETHOD
GC
GC
SOMBER
OF CASES
26
26
RABGE
0.07-0. 3 ug/g
0.3-3 ng/ml
BEAN
0. 1 ug/g
Bedian
0.5 ng/ml
Median
GEBEBAL IBFORBATION
Analytically indistinguishable £ron
2,3, 6, 3*. 4' -pentachlorobiphenyl
Capacitor manufacture workers. 1976
clinical health survey.
AEIPOSE TISSUE; BLOOD PLASBA;
POIYCHLORISATED EIPBENYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
Analytically indistinguishable from
2, 3, 6, 3 ',4' -pentachlorobiphenyl
Capacitor manufacture workers. 1976
clinical health survey.
ADIPOSE TISSUE; B100D PJ.JSBA;
POLICH10RIMATED EIPHEBItS;
OCCUPATIONAL HAZARDS; INDUSTRIES
REFERENCE
"Olff. M.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
"clff, B.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1962
Toxicology and Applied
Phanacology 62:291-306
Biphenyl, 3,3«,5,5'-tetrachloro- (8 CI)
1,1'-Biphenyl, 3,3',5,5'-tetrachloro- (9 CI)
3328U-52-5
C12-H6-C1H
»» 291.98
TISSUE
6146
Adipose
6147
Blood,
plasma
EXPOSURE ROOIE
ANALYTICAL
METHOD
GC
GC
NUMBER
OF CASES
26
26
BADGE
0.04-3 ug/g
0.2-42 ng/ml
' BEAU
0.3 ug/g
Median
1 ng/»l
Median
GENERAL INFOPBATICN
Analytically indistinguishable from
2,3,4,2'-tetrachlorobiphenyl
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBAj
EOIYCHLORINATID BIPHENYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
Analytically indistinguishable from
2,3,4,2'-tetrachlorobiphenjl
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
EOIYCBLOBINiTID EIPHBNYLS;
OCCBPiTIONAL H1ZABDS; INDUSTRIES
REFEBENCE
Wolff. B.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff. I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
Wolff, 9.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
-------
Eiphenyl, »,a«-dichloro- (8 CD
I.l'-Biphenyl, 4,4'-dichloro- (9 CI)
2050-68-2
C12-H8-C12
US 223.11, »P 148-H9 C, BP 315-319 C
TISSUE
Adipose
61U9
Blood,
plasBa
EJPOStJBE ROUTE
ASALYTICJL
BETBOD
GC
NOI1BEB
Of C1SES
26
BADGE
. ug/g
0.03-2 ng/il
HEiN
Hedian
0.7 ng/«l
Median
GEHEBAL IHFORBATICN
clinical health survey. Relative
concentrations used to calculate
adipose-plasia partition
ADIPOSE TISSUE; BLOOD PIASBA;
POIYCBLORINATED EIPHENYLS;
OCOTPATIOSAl HAZARDS; IHDOSTBIES
concentrations used to calculate
adipose-plasia partition
ADIPOSE TISSOE; BLOOD PLASBA;
PCLYCBLOHINATED EIPHENYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
B
Thornton
Fischbei
Lilis, R
Selikoff
1982
Toxicolo
Phamaco
Holff. »
Thornton
Fischbei
Lilts, B
Selikoff
1982
Toxicolo
Phataaco
DEFERENCE
Eroaine
7726-95-6
El
itw 79.90U, (IP -7.25 C,
59.07 C, VP 1 .« eg at -60 C, 10 » Hq at -30 C
TISSOE
6150
Aorta
6151
Hair
EXPOSURE ROUTE
AHALYTICJl
BEIHOD
HA
NA
N0HBER
OF CASES
a) 9
b) 9
c) 9
d) 9
e| 9
f) 9
56
Haass
a) 12. 9- 101 ug/g
b) 67.5-110 ug/g
c) 37.9-70.5 ug/g
d) 21.0-127 ug/g
ej 85.8-139 ug/g
f) 29.0-80.9 ug/g
Dry wt
0.47X10 (2-6)-7991X10 (E-6)
g/cu en
(KEJCT
flEAS
a) 70.6 +or- 20.8
ug/g
b) 86.2 tor- 15.1
ug/g
c) 52.3 tor- 10.9
ug/g
d) 64.8 tor- 38.8
e) 104 tor- 17.1 uj/g
f) 60.8 tor- 15.8
ug/g
Dry wt
4. 25X10 (E-6) g/cu ci
PAGE)
GEKERAL IHFOBBATIOK
a) Normal intiia, median 69.7 ug/g
dry wt
b) Normal media, ledian 90.6 ug/g dry
wt
c) Normal adventitia 50.5 ug/g dry wt
d) Atherona intiRa, median 48.8 ug/g
dry wt
dry wt
f) Atherona adventitia, ledian 61.4
ug/g dry wt
Nc correlation with age.
Significantly higher in ledia. No
1 flay-79 yr olds, autopsies
AGE; AUTOPSIES; AOETA; BROBINE
3 ci segnents of single hairs
Sone samples below detection liiits
IFIDIOH; HAIR: FCBEHSIC HECICISE;
BEASUREBEHT BETHODS ; ANTIBCHY:
ARSENIC; BROBINE; COPPER; GOLD;
LAKTHANUB; SAHGA8ESE; BERCOBY;
BIIALS; SELENIOB; SILVER; SODIUB;
S1ROBTIOB; ZI»C; 1SDOSTRIAL
ATBOSPBERES
REFERENCE
Cross, J.D.
Raie, R.B.
S»ith, H.
1981
Journal of clinical
Pathology 34:393-395
Dybczynski, R,
Boboli, K.
1976
Journal of
Radioanalytical
Chenstry 31:267-289
-------
Fronj r;e
772f,-9?-6
Er
At't 79U901, HP -7.25 C, BP 59.147 £, VP t ray I'q a; -60 L, 1u
~ia hg e.t -30 C
1 TISSUE
6152
Hair
'CXPnSDRF POUT1-:
AS«I*TIC»I,
METHOD
HA
_
BUBBEB
or CUSES
EASGE
af 0, 05-9.0 ppa
b) 0.57-4.4 ppu
c) O.U-i.89 ppa
d) 0. 19-9 ppm
.
HE 41'
,jf 2. \ > or- 1 . C ppa
b) 1.65 +OC- 1.26 ppm
c} 0.86 +or- 0.51 ppm
d) 2. 1 >or- 2. 1 ppm
a> 12 ci: length^ 99 sauipi^s
b) Root section, IS saapies
c) Distal section, 18 saaples
d) Students in aj , 30 sanples
INDIA; ADOLESCENTS; ADULTS; HAIE;
ASTIBCST; ABSENIC; BBOnillE; CADBISH;
CFIORIHE; CHBOBIUH; COBALT; COPPER:
GOLD; IODISE: IHOH: LA«THAKOB;
B8HGA1IESE; POTASSIUM; SCAHCIDfl;
SELEBIUB; SILVEE; SODIUB; ZIHC; AIE
ECLLUTION; BIOACCUBDLHIOB; FOSSIL
FUELED POSEE PLANTS; INDOSI8IAL
AEEAS; INDUSTRIAL ATBOSPBEBES;
ISDOSTFIAL BBISSIOHS; INDUSTBIAt
POLLUTION; EOPULA1ION EIPOSUEE; UBBAN
AEEAS; INDtJSTBIAl CHEBICHLS
KEFEEE'ICE
Bhlf. K.E.
Arunackalan* J-
Yeqnasabratuaai.aa , £.
Gangadharan, S.
1982
Environaent 22:169-178
_
Butyl alcohol (8 CI)
1-Eutanol (9 CI)
11-36-3
C"4-H10-0
BB 7U.12, BP 117.5 C, »P 5
Hq at 20 C
TISSUE
6153
Breath
EXPOSURE BOOTE""
ANALYTICAL
METHOD
GC/HS
NUMBER
OF CASES
28
BANGE
1.3-9.5 ng/1
HE4N
3.3 ng/1
GIHEEJL IHFOBHATIOH
Estinated frov graph
Healthy 18-60 yr olds, nonsaofcers.
Eigid protocol 10 days before and
during study to iiniffii7e nunber and
avount of ezogenous constituents.
aDUlTS; BBE1TH; JICOHOLS; CBLOEIHE
CBGiNIC COBPOUSDS; CHLOEOB EBZEBES
B
Krotoszy
Qabriel,
o-8eill.
claudio.
1977
Journal
Chrooiato
15:239-2
C-26 sterol (So postings in CBEBLIHE) .
TISSUE
Elood,
Blood,
plasma
EXPOSOBE ROOTE
Ingestl0n
AHAIYTICAI
BITHOB
oc/ns
oc/ns
8UHBEB
or CASES
BASSE | BEAU
1
1
1
1
1
1
1
1
1
1
1
i
1
i
i
i
i
i
i
i
GEBEEAL IBFOBBATIOS
393 «g/day tor 3-K irk (2 subjects) or
diet, 63U «g/day
2 nortal aen, one 66 yr old
JtUITS; BLOOD PLiSHA; BBITHBOCITES ;
CBOLESTEEOIS: DIETS; FOODS
262 »g/aay for 3-1 »k (6 subjects) or
393 aig/day for 3-1 wk (2 subjects) or
8 »k (1 subject! . Total sterols in
diet, 447 ig/day or 634 eg/day.
8 no rial 23-H7 yr old aen, 1
hypercholesteroleaic 66 yr old uoaan
ADULTS; B100D PLiSBA; ERYTHBOCHES ;
CBOLBSTEBOLS: DIETS; FOODS
flEFEBEHCE
tin, D.S.
1981
81:276-28«
Lin, D.S.
198!
Gastroenterology
81:276-2811
-------
c-29 Sterol (So postings in CBEHLISE).
TISSUE
6156
Blood,
cells
6157
Blood ,
plasma
EXPOSURE ROOTE
Ingestion
I ngestion
ANALYTICAL
M3THOD
TLC
GC/BS
TLC
GC/flS
» OH BEE
OF CBSES
3
9
BAKGE
1.5-2.3 ug/g
Not detectable-U.4 ug/ml
flEAH
1 . 8 ug/g
1.5 ug/ml
GESERJL IHFORBATICN
8 v* (1 subject). Total sterols in
diet, 63U «g/day
2 normal men, one 66 yr old
ADULTS; BLOOD PLJSHA; ERYTEBOCYTES;
CHOLBSTEBOLS: DIETS: PCODS
393 ng/day for 3-t «k (2 subjects) or
8 wk (1 subject) , Total sterols in
diet, i(U7 ng/day or 630 ig/day
hyrercholesterolenic 66 yr old woman
ADULTS; BLOOD PLJSSJ; EBTTHBOCrTBS;
CEOLESTEBOLS; DIETS; TOOOS
BEFEBEBCE
Lin, D.S.
1981
Gastroenterology
81:276-2814
Lit, D.S.
1981
Gastroenterology
81:276-2811
Cadmium
TUUO-U3-9
Cd
its 112.10, flP 321 C, BP 765 C, V? 1 SB flg at 394 C, 10
H Hot gi
dj Not gi
e) Not gi
g) Not gi
h) Not gi
i) Sot gi
1) Hot gi
k) Not gi
1) Hat gi
mj Not gi
n) Not gi
o) Not gi
p) Hot gi
r) Not gi
t) Not gi
EANGE
en
en
en
en
en
en
en
en
en
en
en
en
en
en
en
en
en
BEAM
a) 0.43 ppm
b) 0.5U ppm
c) 0.51 ppffl
d) 0.59 ppm
e) O.yO ppm
g) 0.36 ppm
n) 0.68 ppm
ij 0.48 ppm
1) 0.52 ppm
M 0.27 ppm
1) 0.79 ppm
ra) O.U7 ppu
nj 0.5U ppm
o) 0. 69 ppm
p) 1.04 ppm
r) 0.64 ppm
t) O.H6 ppm
Geouetcics
GFSERAL IHFOBKATIOS
a) Bothers (103)
t) Infants (100)
c) nothers, 16-24 yc old (K8)
-3) Infants cf 6)
e) Bothers, 25-30 yr old (31)
g) Bothers, 31-42 yr o!3 (29)
h) Infants of g)
i) Nocmotensive nothecs and t) . Ho correlation with
parity
Eesidents of eastern France
Inverse relationship between Cd in
infants' hair and birthveight. Cd
levels in infants of hypertensive
ncthers 3 tines > than for mothers.
and significantly > than in infants
of nor mo tensive mothers. positive
and infants
5PRSCE; ADTJI1S; &5E; NEffBOBD; HBIR;
CCIFaSATIVE EVALUATIONS; CADHIUH;
IE1D; PET1LS; BIO&CCOBtJI-kTIOS; £LOOD
EEESSOSE; PREGHfiNCY; PUPAL AREAS
PEfEESNCE
Huel, G.
Boudene, C.
Itrahin, (!. A.
1981
Archives of
36(5) :221-227
S
i
j
-------
Cadmium
7440-43-9
AtU 112.40, fl£> 321 C, BP 765 C, 7P 1 in Hg at 394 C, 10 mm Hg at 486 C
(CONTINUED)
TISSUE
M59
dd renal
gland
6160
Aorta
Blood
EXPOSURE ROOTE
ABAUTICAL
METHOD
ES
ES
BDHBEB
OF CASES
7
7
23
59
BADGE
Sot given
Not given
b) 0.73-3.11 ug/100 ml
c) 0.02-1.92 ug/100 ml
(BEIT
BEAN
2.7 + or- 1.5 ppm dry
wt
2. 1 »or- 0.96 ppm dry
wt
ug/100 ml
b) 1.70 *or- 0. 16
ug/100 »1
c) 0.36 *or- 0.04
ug/100 il
PAGE)
GENEBAL INFOEBATICN
Normal tissue
Autopsies
Japan
JAPAN; AD01TS; ADTOPSIES; ADBEBAL
GIABDS; AORTA; BOKES; BEART;
INTESTINES; KIDNEYS; LIVER; LOHSS;
IYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THIEOID GLANDS; TBACHEA;
AICniSOH; BAEIOII: CADOJI7I1; CAICIDB;
CFROBIOB; CCBALT; COPPEB; IBO»; LEAD;
HAGHESIOB; flANGANESE; BETAIS;
PCLTBDENDB; NICKEL: PROSPHCROS;
FOTASSIUfl; SILICON; SIL7EK: SODIOB ;
S1BONTIDB; TIB; 1IT»HI01: VANADIDH;
ZINC; BIOACCOBULATION; HEJ1TF
BAZASDS; OCCUPATIONAL BAZABDS;
TCHGHE; ZIRCONIOB; ELEBESTS
Normal tissue
Autopsies
Japan
JAPAH; AOOL1S; AOTOPSIES; »DSE»IL
GLANDS; AOBTJ; BONES; BEAE1;
INTESTINES; KIDNEYS; LITER; LONGS;
LYBPH BODES ; PASCEEAS; SPLHEH;
SIOBACH; TBTROID GLANDS; TFJCHEJ;
ALCBIBOB; EARIOB; CACBIUB; CALCIOB;
CEPOBIDH; CCBALT; COPPER: IRON; LEAD;
BAGNESIUB; MANGANESE; BETALS;
BCLYBDEBUH; BICKEL; PBOSPHCBOS;
ECTASSIOB: SILICOB; SILVER ; SODIOM;
SlEOBTIDfl; TIN; TIT1NIOB: VANADIOH;
ZIBC; BIOACCOnOLATIOB; HE11ITB
BAZARDS; OCCOPATIOM»L HAZARDS;
TONGUE; ZIBCOBIDB; ELEBENTS
b) Cd vorkecs with renal disfunction
c) Non-Cd workers at saie Zn-Cd plant
Bean employment 17 (a) , 27 (b) and 18
yr (c) . Bean exposure period 7.5 (a)
and 21.2 yr (b) . Exposure levels 166
ug/cu • (static sampler) or 1192
ug/cu • (personal air monitor) £or a)
118 of 264 workers with liver and
renal cortical Cd levels arove
detection limits (10 and 50 ppn,
respectively)
Blood levels not correlated with body
turden.
plant, Belgiua
Renal dysfunction unlikely if urine
level of 10 ug/g creatinine (180 mg
body burden) is not regularly
exceeded, critical liver level 30-60
215-385 ppm
BILGIDB; ADULTS; KID HEY DISEASES;
BLOOD: BODY; KIDHEYS; LlYlP; ORIHE;
IN TITO ANALYSIS: CADBIUB; BETALS;
HIALTH HAZARDS: INDUSTRIAL
A1ROSEBEEES; IB HALIITIOI ; OCCOP ATIOH1I,
HAZARDS; SHILTEBS
REFERENCE
Teraofca, fi.
1981
Archives of
Environmental Health
36 (»): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(1) : 155-165
Lautierys, R.R.
Buchet, J.P.
Bernard, A.
Chettle, D.B.
Harvey, T.C.
Al-Haddad, I.K.
1981
26:217-2110
00
-------
CadoiuB
7040-43-9
Cd
AtH 112.10,
HP 321 C, Bf 765 C, \e 1 in Hg at 394 C, 10 »« Hg at 486 C
(CONTINJED)
TISSUE
6162
Blood
6163
Blood
6164
Blood
6165
Blood
EJCPOSOBE ROUTE
ANALYTICAL
HETHOD
AAS
AAS
AAS
SOUSES
OF CASES
a) 9
b| 12
c) 1U
d) 12
1
16
72
BANGE
a) Hot given
b) Sot given
c) Hot given
d) Not given
Not applicable
a) 0.6-2.4 ug/100 ml
b| 1.8-5.4 ug/100 ml
c) 0.8-2.5 ug/100 ml
a) Not given
b) Not given
c) Not given
d) Not given
MEAN
a) 25.7 +OE- 3. C
aq/{.L
b) 41.7 +or- 3.8
rig/ml
c) 37.7 *or- 3.3
ug/ml
d) 50.6 *or- 2.7
ng/ml
S.E.
26.3 ug/1
a) 1.4 +or- 0.6
ug/1GG ml
b) 3.5 +or- 1 .5
ug/100 ml
c) 1.5 +or- 0 .7
ug/100 ml
b) 3.5 *or- 1 .7 ng/g
c) 1.9 +or- 0 .6 nq/y
d) 2. 2 +oc- 0. 9 ng/g
GENEBAL INFOB8ATIOM
Age-adjusted values also given.
36-51 yr old hypertensives, systolic
pressures of 158-166. 34-50 yr old
110-124, Boaania
RCBABIA; AGE; HYPERTENSION ; BLOOD;
SBOKING; CADSIOB; METALS: ELOOD
FEESSORE
factory
BLOOD; KIDNEYS; LITER; UBIHE; OBITED
KISGDOU; CADBIOB; HETALS; IHDOSIBIAL
PLANTS; OCCUPATIONAL HAZARDS;
ECfOLATION IXPOSDBE
a) 11 subjects, exposed 1.8-12 BO
b) 5 subjects, exposed 3-19 yr
c) Same as b) , 2 yr later
Workers, Cd-pigaent nanof acturing
plant, Australia
Dyspnea, emchyseaa
Renal tubular daoage
ELOOC; UBISE; AOSTRALIA; CASE
HISTORIES; ISDOSTEIiL DISEASES;
CADBIOB; BETA1S; ISDDSTRIAI PLANTS;
CCCBPATIOBAL HAZABDS; POPULATION
EXFOSOBE
b) Paternal blood, 41 siokers
c^ Cord blocd, 31 nonsaokers
d) Cord blood, 31 nonsaokers
d) cord blood, 41 snokers
a( and b) during active labor
c) and d) iaaediately after delivery
b) significantly greater than a)
b) significantly greater than d)
Mean age 22 and 23 yr, nean infant
birth «t 3094 and 3436 g, lean
gestation time 39.0 and 39.4 «k for
on
CHIO; ADULTS; NBHEOBH; BLOOD;
PLACENTA; CODPARATIVE EVALUATIONS;
CACHIHV, 9ETAIS; THIOCTkSATES;
BIOACCUBOLATtOB; HEALTH HAZARDS;
FBEGNANCY; SSOKIBG
P.EPEREBCE
Revis, «.«.
zinsMeister, A.B.
1981
Proceedings of the
Society for
Experiaental Biology
and Medicine
167:254-260
Gbose, B.R.
Horgan, V.D.
Cuanins, P.E.
1981
38:165-186
De Silva, P.E.
Donnan, H.B.
1981
British Journal of
Industrial nedicine
38:76-86
Fuhnert, P. n.
Kuhnert, E.R.
BottOBS, 5.F.
Erhard, p.
1982
iaerican Journal of
Obstetrics and
Gynecology 142:1021
(BEXT PAGE)
.p-
VD
-------
Cadnium
7UUO-H3-9
a
t» 112.10, MP 321 C, BP 765 C, VP 1 mm Hg at 391 C, 10 mm Hg at 486 C
(CONTINUED)
TISSUE
6166
Blood
6167
Blood,
cells
6168
Blood,
plasna
EXPOSURE HODTE
ANALYTICAL
METHOD
MS
AAS
ft AS
NUMBER
OF CASES
a) 39
D) 12
c) 13
a) 20
b) 20
c) 10
d) 10
el 30
f) 30
a) 20
W 20
c) 10
d) 10
e| 30
t) 30
RANGE
a) 1.50-26.50 ug/1000 ml
b) 2.5-37.0 ug/1000 ml
ol 1.1-3.0 ug/1000 ml
a) Mot given
p) Not given
c) Sot given
d) Not given
e) Not given
£1 Not given
a) Not give
b) Hot give
c| Not give
d) Sot give
e| Not give
f) Hot give
MEAN | GENERAL INFORMATION
1
I
a) Not given
b) Not given
c) Not given
a) 23 +or- 11 ng/g
b) 21 »or- 22 ng/g
c> 6.2 +oc- 3.9 ug/g
d) 1. 1 +or- 3. 8 ng/g
e) 9.3 *or- 4.7 ng/j
f) 1.1 »or- 3.0 ng/j
Dry wt
a) 95 *o - 17 ng/g
b) 119 * r- 163 ng/g
c) 35 +o - 27 ng/g
d) 28 +o - 11 ng/g
e) 15 to - 26 ng/g
£| 11 to - 10 ng/g
Dry wt
a) Sorters at Ni-cd batterj plant,
average workplace tine 1.5 yr
b) workers at Zn-cd smelter, average
ti«e 11.5 yr
c) Controls. Median 1.6 ug/1000 nl
5-95 percentile range
GERMANY; ADULTS; BLOOD; HEINE;
COMPARATIVE EVALUATIONS; INDOSTRIAL
BErlCIKE; ClOalOR; LEAD; SIBCORY;
riTALS; PROTEINS; HEALTH HAZARDS;
INDUSTRIAL PLANTS; OCCUPATIONAL
HAZARDS; SMELTERS
a) Adults, cardiovascular disease,
urban area
c) Adults, cardiovascular disease,
rural area
e) High schccl seniors,
hypertensives, urban area
Erythrocytes
Adults, Bean age 55 yr, and students,
Chatham and Evans counties, GA
Depressed erythrocrte glutathione
ceroxidase
CADfllOB; METALS: SELENIUM; BURAL
AREAS; URBAN AREAS; GEORGIA;
CABDIOVASCULAB DISEASES;
HYPERTENSION; BLOOD; BLOOD PLASMA;
ERYTHROCYTES
a) Adults, cardiovascular disease,
urban area
rural area
Adults, mean age 55 yr, and students,
Chatham and Evans counties, GA
Depressed erythrocyte glutathione
peroxidase
CADHIDH; METALS; SELENItJH; BORAl
HFFAS; UBBAK AREAS; GEORGIA;
CfiFDICVaSCDLAE DISEASES;
HKPEBTENSIOH; BLOOD; BIOOD PLASHA;
EFTTHBOCYTES
BEPEHEHCE
Schaller, K.H.
Gonzales, J.
TharauE, J.
Schiele, a.
1980
Zentralblatt fuec
Bakter iologie,
Parasitenkunde ,
iDfektioQSkcankheiteu
und Hygiene, Abteilung
1. originale, P.eihe B.
Hygiene, Preventive
Hedizin 171:320-335
Andrews, J. W.
Hanes, C.G.
Hetts. J.C. , Jr.
Davis, J.R.
1980
Proceedings , D Diversity
Conference on Trace
S ubstanceS in
Bnviron*ental Health
U-.33-H2
Andrews, J. W.
Hases, C.G.
Metts, J.C., Jr.
Davis, J.n.
1980
Proceed ings , D diversity
of Missouri Annual
Conference cm Trace
Substances in
EDYironnental Health
14:33-1*2
(NEXT PAGE)
-------
CadBiuo
7490-43-9
Cd
At» 112.40, HP 321 C, BP 765 C,
Hg at 394 C, 10
Bg at 486 C
(COSTISaEP)
TISSUE
6169
Blood,
whole
6170
Body
6171
Bone
EXPOSURE POD1E
ANALYTICAL
METHOD
AAS
n
ES
HUHBER
OF CASES
a) 20
b) 20
c) 10
3) 10
e> 30
£) 30
a) 66
b| 23
c) 59
5
RANGE
a) Hot given
b) Hot given
c) Hot given
d) Not given
e) Hot given
f) Hot given
a) 64-300 «g
b) 134-556 mg
c) 62-221 «g
Sot given
(NEXT
MEAN
a) 6.5 o - 3.4 Dg/ol
b) 7.0 0-3.1 ug/Jii
c) 1.9 0-0.7 ng/al
d) 1.2 0-0.8 ng/ml
e) 1.8 o - 1 . 1 og/mj.
£) 1.0 0-0.7 ng/al
a) 171.5 tor- 7.33 «g
b) 284.5 + or- 25.7 mg
c) 104. 6 +or- 4.48 mg
<4.0 ppm dry wt
PAGE)
GEHERAL ISFORBATION
urban area
b) Controls for a)
c) Adults, cardiovascular disease.
rural area
hypertensives, urban area
f) Controls for e)
Adults, mean age 55 yr, and students.
Chatham and Evans counties, GA
Elevated blood Cd levels depressed
erythrocyte glutathione peroxidase
levels
CADBIUB; BETALS; SELEBIUH; BOBil
AREAS; URBAN AREAS; GEORGIA;
CARDIOVASCULAR DISEASES;
HYPERTENSION; BLOOD; BLOOD PLASHA;
EEYTHROCITES
a) cd workers, nc renal dysfunction
b) Cd workers with renal dysfunction
c) Non-Cd workers at sane 2n-Cd plant
Bean employment 17 (a) , 27 (b) and 18
yr (c) . Mean exposure period 7.5 (a)
and 21.2 yr (b) . Exposure levels 168
ug/cu B (personal air Bonitor) for a)
and. b) , and 0. 1— 15 ug/cu n for c)
148 of 264 workers with liver and
renal cortical Cd levels above
detection limits (10 and 50 ppn.
respectively)
Estimated from kidney and liver
levels
plant, Belgium
Renal dysfunction unlikely if urine
level of 10 uq/g creatinine (180 mg
tody burden) is not regularly
exceeded. Critical liver level 30-60
ppn. critical renal cortical level
21^-385 ppm
EEIGIDH: AUDITS; KIDSET DISEASES; '
E100D; BODY; KIDNEYS; LIVES; OBIHE;
IB VIVO ANALYSIS; CADBIOH; BETA1S;
HEALTH BAZABCS; INDUSTRIAL
ATMOSPHERES; I»H*L1TIO»; OCCUPATIONAL
HAZABDS; SHELTERS
Nornal tissue
Autopsies
Japan
OAPAS; ADOLTS; AUTOPSIES; ADRENAL
GIANDS; AORTA; BONES; HEABT;
INTESTINES; KIDNEYS; LIVEB ; LONGS;
LYBPH NODES; PANCBEAS; SPLEEN;
ST01ACH; THYBOID GLANDS; TBSCHEA;
JICHIBOH; EAIIBfl; CADBIffS; CALCIO-fl;
CRPOKIDM; COBALT; COPPER; IRON; LEAD;
HAGNESIOtl; ttANGANESE; HETALS;
PCLYBDENOB; NICKEL; PHOSPHCROS;
EOTASSIOH; SILICON; SILVER; SODIUH;
STROSTIOB; TIN; TITASIOB; VASADIDB;
ZINC; BIOACCOfinLAIICN; HEAITH
HAZABCS; OCCOPATIOHAL HAZARDS;
TONGUE; ZIPCONIOB; ELEBENTS
BEPERBNCE
Ha.es, C.G.
Betts, J.C., Jr.
Davis, J. ».
1980
Proceedings, University
Substances in
Environmental Health
14:33-42
Boels, H.A.
Lauwerys, B.R.
Buchet, J.P.
Bernard, A.
Chettle, D.B.
Harvey, T.C.
1981
26:217-210
Teraoka, H.
1981
Archives of
36(4): 155-165
-------
Cadmium
7U40-43-9
ca
At« 112.10, HP 321 C, BP 765 c, VP 1 In Rg at 3914 C, 10 «m Hq at 486 C
(CONTINUED)
TISSUE
6172
Eone
6173
Hair
6175
Hair
6176
Hair
EXPOSURE ROUTE
ANALYTICAL
BETHOD
Nft
HA
NA
AAS
NUBEEP
OF CASES
7
55
3
BANGE
0.038-0. 043 ppn
0.61-0.85 ug/g
a) 0,06-5.0 ppm
b) 0.06-1.511 pp»
c| 0.09-1.23 ppn
d) 0.06-5.0 ppn
a) Nat given
b) Not given
c} Not given
d) Not given
e) Not given
f) Not given
1
MEAN
Not given
0.71 ug/g
given
a) 0.86 +or- 0.33 ppn
o) 0.9 »or- 0.45 ppm
c) 0.62 tor- 0.36 ppm
3) 0.93 tor- 1.02 ppm
a) 1. 18 ug/g
b) 0.87 ug/g
c) 1.03 ug/g
d) 0. 18 ug/g
e) 5.11 ug/g
f) 0.43 ug/g
I GENEBAL INFORMATION
1
[
J
Autopsies, femur
45-75 yr old factory workers, Sveden
ANTIBONY; ABSENIC; CADBIUB; COPPER;
ZINC; EIOJCCD8ULATION; INDUSTRIAL
ATKOSPHERES; INDUSTRIAL PLANTS;
EOPtJLATION EXPOSURE; SBELTEBS; BONES;
fIBDR; COHPAEATIVE EV1LOATIOHS;
SSEDEN; AUTOPSIES; OCCUPATIONAL
HAZARDS; BETALS
Range of leans, 5 localities
ACULTS; BAIB; ASSEHIC; CADSICIB;
HEFCDEY; BETALS; SELENIOS; ZINC
g , • g p
Aswan, Tl Kharga, Assnit, Cairo, and
Alexandria, Egypt
EGYPT; HAIR; SAILS; ANTIBONY;
CADMUS; CESiaa; CHBoninn; COBALT;
IRON; HANGANESE; BETALS; BOLYBDEHOB;
SCANDIUfi; SBLEKIOB; SILVER; TOKGSTEN;
ZINC; DRINKING WATER; POPULATION
EXPOSURE; SOILS; URBAN AREAS
a) 12 cf length, 99 saaples
b) Root section, 18 sanples
c) Distal section, 18 sanples
d) Students in a) , 31 saaples
levels higher in people near fossil
industry.
Betropolitao Boabay , India
INDIA; ADOLESCENTS; ADULTS ; HAIR;
AHTIB08Y; ABSENIC; BBOBISE; CACBIOB;
CHLORINE; CBROBIUB; COBALT; COEEER;
GOLD; IODIDE; IRON; LANTHANDB;
BASGANESB; POTASSIOB; SCANDIDB;
SELENIDB; SILVER; SODIOB; ZINC; >IR
POLLUTION; EIOACCDBULATION; FOSSIL
FOELED POBEE PIADTS; ISDUSIRIAL
AREAS; INDUSTRIAL ATBOSPBEBES;
INDUSTRIAL MISSIONS; INDUSTRIAL
POLLUTION; POPULATION EXPOSURE; UBBAN
AREAS; INDUSTRIAL CHEBICALS
a) Subject 1, unwashed hair
b) Subject 1, after 12 successive
acetone washes
c) Subject 2, unwashed hair
d) Subject 2, after 12 successive
acetone washes
e) Subject 3, unwashed hair
f) Subject 3, after 12 successive
washes in sodiui lanryl sulfate
a), c) , e) , 6-10 determinations, each
subject. Data also for other
procedures and washing agents.
HAIR; COBPA8ATI?E EVALUATIONS;
CADnitJH; COffEK; IRON; nANCANESE:
ZINC
REFERENCE
Lindh, U.
Brune, D.
Hordberg, G.
Hester, P.-O.
1980
Environment 16:109-116
Johannesson, T.
Lunde, G.
1981
Acta Pliarmacologica et
Toxicologica 46:185-189
lyengar, G.v.
Peinendegen, L.E.
Hashish, S.
Bahfouz. fl.
1982
Science of the Total
Environment 22:149-168
Bhat, K.B.
Arunacbalam, J.
Yegnasubramanian , 5.
Gangadharan, 5.
1982
Environment 22:169-178
Saliela* S.
Vaori, E.
Kilpio, J.o.
1981
Analytica Chimica Acta
125:131-137
(NEXT PAtoE)
U1
K)
-------
CadBium
71440-43-9
Cd
AtW 112.10, HP 321 C, BP 765 C, VP 1 mm Bg at 394 C. 10 111 Hg at 486 C
(CONTINUED)
TISSUE
6177
Heart
Intestine
6179
Kidney
EXPOSURE POOTE
mALYTICAL
SETHOD
ES
ES
ES
B OK BEE
OF CASES
a) 8
t>) 2
C) 3
d) 1
e) 1
_.
a) 8
b) 2
c) 3
d) 1
e) 1
BIHGE
a) Not given
b) 0.45-1.7 ppi
c) 5.7-20 ppn
d) Not applicable
e) Hat applicable
Dry »t
given
a) Mot given
b) 17-76 ppn
c) 25-130 ppm
d) Not applicable
e) Sot applicable
Dry wt
HEA»
a) 0.67 +or- 0.32 ppm
b) 1.07 ppB
c) 12.6 ppB
d) 1.5 ppi
e) 2.7 ppm
Dry »t
wt
a) 49 *or- 23 ppm
b) 46 ppi
c) 66 ppm
d) 3.9 ppm
e) 7.0 ppm
Dry wt
GEHEBAL I»FORB»TTOS
a) Normal healthy Ben
b) Chromium plating workers
c) ChroBate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; BEAST;
IBTESTIBES; KIDNEYS; LIVER; LOTOS;
LY.BPH HODES; PkHCBEkS; SPLIEK;
S10BACB; THIBOID GLANDS; TBACBEA;
HLOHI1HJH; BARIOB; CADBIO!!; CALCIOII:
CHEOBinil; COBALT; COPPEE: IBOS; LE1D;
PAGNESIOB; BANGANESE; BETA1S;
HCITBVEHUH; MICKEL; PHOSPHOBOS;
POTASSIOH; SILICON; SILVER; SODIOfl ;
SIRONTIOfl; TIN; TITANIOH; VAUADIOn;
ZIHC; BIOiCCDBOLATION; BEALTB
BIZAPDS; OCCDPATIONAL BAZAEDS;
TCNGtIS; ZIECCNIOB; ELEHENTS
Autopsies
JAPAN; ADDLTS; AUTOPSIES; ADREVAL
GLANDS; AOETA; BONES; HEABT;
INTESTINES; KIDNEYS; LIVEE; LONGS;
LYBPH NODES; PAMCEEAS; SPLEEN;
STOHACB; THYROID GLANDS; TEACBEA;
ALCBIHDH; BARIOM; CADBIOH; CALCIOfl;
CPROBIHB; COBALT; CCPPEB; IEON; LEAD;
HAGNESIHB: BANGANESE; BETALS;
BOLYBDENtJB; NICKEL; PBOSPBOBOS;
FCTASSICB; SILICON; SILVER; SODIUB;
S1PONTIDB; TIK; TITiNIOfl; 7ASADIW;
ZINC; BIOACCOBOLAHON; HEAITB
HAZARDS; OCCUPATIONAL BAZABDS;
TCNGOE; ZIRCONIOB; ELEBENTS
a) Nornal healthy nen
b) chroniuB plating workers
d) Airplane painter
6) Stone mason
Autopsies
Japan
JAPIS; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BEART;
INTESTINES; KIDNEYS; LIVER; LDUGS;
IYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TEACHEA;
ALCBINDB; BASIOH; CADBIOB; CALCMB;
CBROHWH; COEiLT; COPPER; IEON; LEAD;
BAGKESIDB; BANGANESE; BETAIS;
eClYBDZNDB; NICKEL; PHOSPHCBDS;
pOTASsina: SILICON; SILVER; SODIOBJ
STRODTIUB; UN; TITANIOB; VANADIUB;
ZINC; BIOACCOBDLATIOB; HEAITB
HAZARDS; OCCOPATIONAL HAZAEDS;
TCNGOE; ZIRCONIOfl; ELEBEHTS
EEFEBENCE
Teraoka, fl.
i?ei
Archives of
Environmental Bealth
36(1): 155-165
1981
Archives of
36 («): 155-165
Teraoka, B.
1981
Archives of
36(4) : 155-165
(NEXT PAGE)
-------
Cadmium
7440-43-9
ca
Jtw 112.10, HP 321 C, BP 765 c, VP 1 mm Hq at 394 c, 10 im tig at 486 c
(CONTINUED)
TISSUE
6180
Kidney
6181
Kidney
6132
Kidney
EKPCSORE ROUTE
ASAIYTICAL
HETHOD
NA
HA
HA
» OS DEB
or CASES
a) 66
b) 23
c| 59
1
a) 7
b) 7
C} 1
a> 12
BASSE
a) 51.7-310.3 pp«
b) 103.4-300.0 ppm
c) 51.7-248.3 ppm
Not applicable
a) Not given
b) Not given
c) Not given
3) Hot given
ill' AS
a) 167.4 tor- 8. 17
ppm
b) 175.4 *or- 13.7
pp»
c) 112.9 + or- 6.36
pp.
39 *or- H mg
a) 3. 1 mg
b) 4.6 mg
c) 6.0 mg
1) 23.6 mg
GENERAL ISFORHJTICN
b) Cd workers vith renal dysfunction
c) Non-ca workers at same 2n-Cd plant
ffean employment 17 (a) , 27 (b) and 18
yr (c) . Mean exposure perioa 7.5 (a)
ana 21.2 yr (b) . Exposure levels 168
ug/cu m (static sanpler) or 1192
ug/cu m (personal air monitor) for a)
and b) , and 0.1-15 ug/cu m for c)
146 of 264 workers with liver ana
renal cortical ca levels above
detection limits (10 and 50 ppm,
respectively)
Analysis based on mean kidney aepth
of 5 cm, values should be increased
35* for mean depth of 8 cm
plant, Belgium
Renal dysfunction unlikely if urine
level of 10 ug/g creatinine (180 mg
body burden) is not regularly
exceeded. Critical liver level 30-60
215-385 pp»
EI1SIOB; ADULTS; KIOBEy DISEASES;
E1000; BODY; KIDBEYS; LIVES: OEIHE;
IN VIVO ANALYSIS; CADMIUM; BETAtS;
HEALTH HAZARDS; INDUSTRIAL
ATMOSPHERES; INHALATION: OCCOPATIOHiL
HSZARDS; SHEITEBS
Mean of 3.8 mg in 60 non-exposed
subjects
37 yr old worker, N1/C3 battery
factory
EIOOD; KIDNEYS; LIVID; DRINE; aHITED
K1HGDOH; CADHIOB; SETALS; INDUSTRIAL
PIASTS; OCCOPATION1L HAZARDS;
POPULATION EXPOSOBE
.
a) Controls, mean age 40.3 yr, no
occupational exposure
t) Office workers, mean age »4.0 yr,
employed 0.7-34.0 yr
c) Smelter workers, mean age 26.3 yr,
employed 0.1-0.3 yr
employed 8.0-29.0 yr
d) significantly higher than a) , b) ,
and c)
Group d> excreted significantly more
metallothionein in urine than a), b) ,
and c)
Employees, Cd production plant and
water plant employees (controls)
JCOLTS; KIDN1YS; 1IVEH; CADItlOH;
BETALS; PROTEIBS; BIOACCBBOLATIOS;
IBDOSTRIAL ITBOSPHEBES; OCCOPATIONAL
HAZARDS; SrtflTEfiS
REFERENCE
Lauwerys, B.R.
Buchet, J.P.
Bernard, A.
Chettle, D.E.
Harvey, T.C.
Al-Haddad, I.K.
1981
26:217-240
Ghose, B.B.
Morgan, fl.D.
Cummins, P. B.
1981
British Journal of
Industrial Medicine
38:185-186
Tohyama, C.
Shaikh, Z.A.
Ellis, K.J.
Cohn, S.H.
1961
Toxicology 22: 181-191
(NEXT PAGE)
Ul
-------
cadmium
74HO-43-9
ca
AtW 112.10, MP 321 C, BP 765 c, VP 1 mm Hg at 394 C, 10 ma Hg at 486 C
{COSTIS3ED]
TISSUE
6193
6184
liver
6135
liver
_
EXPOS0KE POOTE
ANALYTICAL
BETHOD
AAS
ES
AST
LSV
HA
_
NOKBEE
OF CJISES
123
a) 9
b) 2
c) 3
e) 1
30
BANGE
a) Not given
c) «ot given
d) Not given
e) Hot given
f) Not given
g) Hot given
i) Not given
j) Not given
a) Not given
b) 3.0-17 ppia
cj 23-43 pps
e) Not applicable
Dry wt
0.5-4. 9 ug/g
Wet wt
MEAN
a) 14.8 + or- 12.2
b) 11.1 *or- 9. 5 ug/g
c) 21.0 +or- 8.0 ug/g
d) 9.8 +or- 7.7 ug/g
e) 15.0 +or- 9.8 uy/g
f) 20.3 +or- 17.3
g) 21.2 +or- 10.2
ug/g
ug/g
i) 16.7 *or- 6.2 ug/g
j) 9.0 *or- 10.5 ug/g
M 22.0 +or- 14.9
ug/g
a) 7. 1 tot- 4. 1 ppm
b) 10.0 ppm
cl 32 ppn
e) 8.4 ppm
Dry wt
sot given
GENERAL IMEORHRTIC8
a) AH cases 123
c) Smokers, 48 cases
d) Cigar smokers, 4 cases
e} Cancer, ncn- seokers f 21 cases
g) Cancer and metastases.
h) Cancer and raetastases, snokers, 6
cases
j) Other, D en- smokers, 16 cases
k} Other, saokers, 12 cases
Autopsies
Sioking and nonsnoking patients
CADKItff!; METALS; SEtEHIOH; 2ISC;
CAEAVERS; CARCI NORAS; HYPERTENSION;
KICHEY DISEASES; LEOKEMIA; KIDNEYS;
SHORING
a) Nornal healthy sen
b) Chroiiun plating workers
c) Chromate refining workers
e) Stone nason
Autopsies
JAPAN; ADULTS; ADTOPSIES; ADRENAL
GIANDS; AORTA; BOMBS; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYWH BODES; PANCREAS; SPLEEN;
STDHACH; THYROID GLANDS; TFACHEA;
ALOHINDH; BARIOH; CADMIUM; CALCIUM;
CHBONIUH; COBALT; COPPER; IRON; LEAD;
MAGNESIUM; MANGANESE; METALS;
HClYBDSyUH; NICKEL; PHOSPffCBUS;
EOTASSIUM; SILICON; SILVER; SODIUM;
STEONTIDM; TIN; TITANIUM; VANADIUM;
ZINC; BIOACCOHTJLATIOH; HEA1TH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGDE; ZIRCONIUM; ELEMENTS
Category 1 (first priority element)
as proposed by International workshop
on Monitoring Environnental Materials
and S pec i Ben Banking
Autopsies, Baltimore, MDf
Minneapolis, HNf and Seattle, HA
B&BYLMID; MISNES01A; BASHISGTON;
AUTOPSIES; LIVES; MEASUREMENT
METHODS; ALUMINUM; ANTIHONY; APSENIC;
EAEIUM; CADMIDM; CHEOMIOM; COBALT;
CCPPEB; FLUORINE; IRON; LEAD;
MANGA8ESE; nERCORY; HOLYBDESUH;
NICKEL; BUBlDIUM; SELENIUM; SILVER;
S3RONTIDM; THALLIOM; TIW; VANADIUM;
7IBC; POPULATION EXPOSURE
BEFEBEHCB
Shaabergec, B, J.
1980
proceedings. University
Substances in
1t;203-210
Teraoka, H.
1981
Archives of
36 (l|) -.155-165
Harrison, S.H.
Zeisler, fi.
aise, S.A.
1981
EPA 600/S1-81-025, 6
pp.
(NEXT PAGE)
-------
Cadmium
7« 59
1
a) 7
b) 7
c) 1
d) 12
BADGE
a) 10-61 ppm
b) 28-158 ppm
c| 10-39 ppm
Not applicable
a) Not given
b) Hot given
c) Not given
d) Not given
GENEBAL INFOBIUTION
a) 32.8 +or- 1.67 ppm
b) 66.5 +or- 7.57 ppm
c) 18.7 *or- 0.92 ppm
*or- 3 ug/g
a) 3.2 ug/g
b) 8.6 ug/g
c) 2.9 ug/g
d) 39.2 ug/g
Geometric Bean
a) Cd workers, nc renal dysfunction
b) Cd workers with renal dysfunction
c) Non-Cd workers at same Zn-Cd plant
Bean enployient 17 (a), 27 (b) and 18
yr (c). (lean exposure period 7.5 (a)
and 21.2 yr (b) . Exposure levels 168
ug/cu m (static sampler) or 1192
ug/cu m (personal air monitor) for a)
and b) , and 0.1-15 ug/cu m for c)
118 of 261 workers with liver and
renal cortical Cd Levels atove
detection limits (10 and 50 ppm,
respectively)
Active and retired workers at Zn-Cd
plant, Belgium
EILGIUH; ADULTS; KIDNEY DISEASES;
BLOOD; BODY.; KIDNEYS; LIVES; URISE;
IN VI70 ANALYSIS; CADflIOH; HETALS;
HEALTH HAZABDS; IHDOSTBIAL
ATBOSPHEBES; INHALATION; OCCUPATIONAL
HAZARDS; SBELTEBS
37 yr old worker, »i/Cd battery
factory
No glorceriilar or tubular proteinuria
BLOOD; KIDNEYS; LIVEB; URINE; UNITED
KINGOOB; CACaiUH; HETALS; INDUSTRIAL
PLANTS; OCCUPATIONAL HAZARDS;
PCPDLATION EIPOSOBE
a) Controls. »ean age 10.3 yr, no
occupational exposure
fc) Office vcrkers, mean age 44.0 yr,
employed 0.7-3tt.0 yr
c) Snelter workers, mean age 26.3 yr,
eiployed 0.1-0.3 yr
d) Saelter workers, lean age 50.3 yr,
enployed 8.0-29.0 yr
d) Significantly higher than a)„ b) ,
acd c)
b) significantly higher than a)
Group d) excreted significantly nore
Bctallothionein in urine than a) , b) ,
cr c)
Employees, Cd production plant and
water plant employees (controls)
ADULTS; KIDSEYS; LIVER; CAEfllOH;
HETALS; PKOTEIHS; BIOiCCUHOliTICH;
IND0STEI1L ATMOSPHERES; OCCUPATIONAL
HAZARDS; SHELTERS
Boels, H.A.
Lauuerys, G.B.
Buchet, J.P.
Bernard, A.
Chettle, D.E.
Harvey, T.C.
Al-Haddad, 1.1C.
1981
Environmental Research
26:217-210
Ghose, B.H.
Morgan, tf.D.
Cummins, P.E.
1981
British Journal of
Industrial Jledicine
38:185-186
Tohyama, C.
Shaikh, Z.A.
Ellis, (C.J.
Cohn, S.H.
1981
Toxicology 22:181-191
(NEXT PAS2)
-------
Cadmium
7MO-43-9
Cd
Atw 112.10, PIP 321 C, BP 765 C, vp 1 mm Hg at 394 Cf 10 mm Hg at 186 C
(CONTINUED)
TISSUE
Lung
6190
Lyiph
node
6191
Sail
EXPOSURE BOOTE
ANALYTICAL
HETHOD
ES
NA
NUBBEB
OF CASES
b) 2
C) 3
d) 1
e) 1
a) 3
b) 1
c) 3
d) '
e| t
63
flANGE
b) 0.6-6.3 ppm
c) 3.3-23 ppn
d) Not applicable
e) Not applicable
Dcy *t
a) Not yiven
b) Sot applicable
c) 2.5-31 ppm
d) Not applicable
e) Not applicable
Dcy wt
0.08-0. 53 ug/g
MEAN
D) 3.4 ppD
C} 11.1 ppm
d) 5. 1 ppm
e) 7.0 ppm
Dry wt
a) 2.5 tor- 0.70 pp»
b) 0.8 ppm
0) 12.8 ppm
c) 9.4 ppm
e| 21 ppm
Dcy wt
Not given
GEHEBAL ISFOBHATIOH
b) chroniuii plating workers
d) Airplane painter
e) Stone lason
Autopsies
Japan
JAEAH; ADULTS; AUTOPSIES; ADEENAL
GL8SDS; AOETA; BONES; HEART;
INTESTINES; KIDHEYS ; LIVEE; LUBGS;
lYBPfl MODES; PASCBEAS; SPLEES;
SIOBACH; THYEOID GLANDS; TB1CHEA;
ALCBIKUB; BARIIIB; CADBIUB; CALCIUB;
CPBOBIUB; COBALT: COPPEE; IEON; LEAD;
BAGHFSIUH; BANGANESE; BETALS;
I-OLTBBEBUB; HCXII; PHOSPHCBUS;
EOTASSIUB: SILICON; SIL7EP; SODIUB;
STBONTIUfl; IIS; TITANIOH; ViNADIUB;
ZINC; BIOACCDBULATIOS; HEALTH
HJ2APDS; OCCUPATIONAL HAZABDS;
TCNGUE; ZIECOHIUB; ELEBENTS
a) Normal healthy Den
b) Chromium plating worker
c) Chromate refining workers
d) Airplane painter
e) Stone nason
Autopsies
Japan
JAEAH; AOUITS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BOHES; HEAR!;
INTESTINES; KIDNEIS; LITEB ; LUNGS;
UBPH NODES; PANCEEAS; SPLEEN;
STOBACH; THIROID GLANDS; TRACHEA;
ALOBIliUB; BAEIUB; C1DBIUB; CALCIDB ;
CBEOBIUfl; COBALT; COPPEB; IBOB; LSAC;
BAGNESIUB; flANGAKESE; BETALS;
B01TBDENUB; NICKEL; PBOSPHCHUS;
EOTASSIUB; SILICON; SIL7EB; SODIUfl;
saBONTIUI; TIN; TITANIUB; VANADIUd:
ZINC; EIOACCUBULA1ION; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TCBGBE; ZIRCONIOB: ELEBENTS
Range of means, estimated from graph
Asvan, EL ^harga, Ass\litr Cairo, and
Alexandria, Egypt
EGYPT; HAIE; NAILS; ANTIMONY;
CADBIUB; CESIUfl; CHROBIHB; COBALT:
IBON; BANGASESE; HETALS; BCLYBDENUB;
SCANDIDB; SELENIUM; SILVEB; TUNGSTEN;
ZINC; DPINKIBG SATEB; POP01ATIOH
EXPOSURE; SOILS; OSBAS ABEAS
BEFEEENCE
1981
Archives of
36 (it) : 155-165
Teraoka, H.
1981
Archives of
Environnental Health
36(«) : 155-165
Kasperefc, K.
lyengar, G. V.
Feinenciegen, I.E.
Hashish, S.
nahfouz, M.
1982
(NEXT P1GE)
-------
Cadmium
74UO-43-9
Cd
Ats 112.140,
BP 321 C, BP 765 C. vp 1 mm Hg at 394 c, 10
Hg at 486 C
(CONTINUED)
TISSDE
6192
Pancreas
6193
Placenta
619H
Spleen
EXPOSORE ROOTE
ANALYTICAL
HETHOD
ES
A AS
ES
NUMBER
or CASES
5
a) 31
b) 41
a) 9
W 2
0 3
el 1
BINGE
Not given
..
Not given
.
a) Hot given
1>| a. 3-7. 3 pp«
c) 6.3-48 ppm
e) Hot applicable
Dry »t
BEAN
5.8 *or- 2.4 ppm dry
wt
a) 13.7 *oc- 6.4 ng/g
b) 18.1 +or- 7. 3 ng/g
a) 2.3 +or- 1.7 ppa
b) 3.8 ppm
C) 21.3 ppn
e) 7.6 ppm
Dry wt
SESEBAI INFORHATIOH
Nornal tissue
Autopsies
Japan
JAFAH; AD01TS; AUTOPSIES; ADEENAl
GLANDS; AORIA; BONES; BEAHI;
INTESTINES; KIDNEYS; tlVEB ; LDHGS;
ITBPH NODES; EANCBEAS; SPLfEN;
SIOBACB; TBIROID GLANDS; TBACHEA;
ALOniNnB; BARI01; CADBIDB; CALCHIB;
CEEOBIDB; CCBALT; COPPER; IBON; LEAD;
nAGBESIOB; (IANGAHESE; BETALS;
BOLYBDENOB; NICKEL; PHOSPHORDS;
FOTASSIOB; SILICON; SILVER; SODIUH;
SIBONIIOH; TIN; TITANItM; VANADIDn;
ZINC; BIOACCnBOLATICN; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGtlE; ZIBCONIOB; ELEMENTS
a) NonsmoXecs
b) Smokers
After perfusion vith sucrose buffer
t) significantly greater than a)
cord blocd levels respectively
Heac age 22 and 23 yr for smokers and
oonsmokers, respectively, CH
CBIO; iDOLTS; NEBBORN; BLOOD;
PLACE »TA; COSPARATIVB E7ALOATIOHS;
CADBIOH; BETALS; THIOCYANA1ES;
BIOACCOBOLATION; HEALTH HAZARDS;
FEEGBANCY; SBOKING
a) Normal healthy men
b) ChroaiHB platiog workers
c) Chronate refining workers
e) Stone mason
Autopsies
Japan
JAPAN; ADOL1S; AUTOPSIES; ADRENAL
GLiSDS; »OBt»; BO»ES; BEAR1;
INTESTINES; KIDNEYS; LIVER; LOUGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACH; THYBOID GLANDS; TBACBEA;
ALOBINOn; BiRIHH; CADnim; CALCIOH;
CBROBIUB; COBALT; COPPER; IROHJ LEAD;
BAGNESIOfi; HANGANESE; BETA IS;
POLYBDENOB; NICKIL; PHOSPHOSOS;
FOTASSIOB; SILICON; SILVER; SODIOfl ;
SIFONTIOH; TI»; TITANIOK; 1ANADIOB;
ZINC; BIOACCOBBLITION; HEALTB
HSZABDS; OCCUPATIONAL HAZABDS;
TONGDE; 2IBCONIOB; ELEBENTS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
Kuhnert, P. B.
Kuhnert, B.R.
Bottoms, S. F.
1982
Obstetrics and
Gynecology 142:1021
Tecaoka, H.
1981
irchives of
36(41:155-165
(NEXT PAGE)
Ol
00
-------
•)U»0-»3-9
ca
Atw 112.HO, BP 321 C, BP 765 c. VP 1 ma Hg at 394 C, 10 nn Hg at 486 C
(CONTINUED)
TISSOE
6195
Stomach
Thyroid
gland
6197
Tongue
EXPOSOBE ROOTS
ANALYTICAL
METHOD
ES
ES
NDBBER
or CASES
10
2
RANGE
Not given
given
Not given
MEAN
2.6 +or- 0.73 ppa dry
wt
vt
0.80 +oc- 0.24 ppjn
dry wt
GENERAL INFOSBATICN
Nomal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLAKDS; AOBT*; BOKES; BB1BI;
ISTES1IMES; KIBSEIS; 1IVEB; LOHGS;
1TBPH MODES; PANCECAS; SPLEEN;
STOHACH; THYEOID GLANDS; TBACHEA;
AlCBISUB; BAEIDH; CADBIOH; CALCIOH;
CEEoninn; COBALT; CCPPEB; IBON: LEAD:
HAGNISIUH; HANGANESE; HETALS;
POLIBDESDB; NICKEL; EBCSPHOROS;
rcTASSion: SILICON; SILVER; soDiun;
STBOSTIUfl; TIN; TITANIOB; VANADIOB ;
ZIBC; BIOACCOBDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUB; ELEHEHTS
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADRENAL
GLASDS; AORTA; BOHBS; HEART;
INTESTINES; KIDNEYS; LIVES; LUNGS;
irflPH 80DES; PAHCBEAS; SPLEES;
STOBACH; THYROID GLANDS; T5ACHEA;
ALDHINDH; BAEIOB; CADBIUB; CALCIDH ;
CHEOBIUB; COBALT; COPPER; IBON; LEAD;
BAGSESIDB; flANGANESE; BETSIS;
PCLYBDENUB; NICKEL; PHOSPHOBDS;
EOTASSIUB; SILICON; SILVER; SODIUH ;
STRONTIUB; TIN; TITANIUB; VANADIUB;
ZINC; BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCSGUE; ZIRCONIUB; ELBHENTS
Noriaal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOSACH; THYSOID GLASDS: TRACHEA;
AICBIBDfl; BAEIOH; CAD8I0M; CALCHJH;
ChROBIUn; COBALT; COPPER; IRON; LEAD;
BAGHESIUB; BANGANESE; BETALS;
fOLY3DENU»; NICKEL; FHOSPHCBUS;
POTASSIUM; SILICON; SILVER; SODIOB ;
STEONTIOB; TIN; TITANIDB; VANADIUB;
ZINC; BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIOB; ELEBENTS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
1981
icchives of
Environmental Health
36(1) t 155-165
T era oka, H.
1981
Archives of
Environmental Health
36 (U): 155-165
(NEXT PAGE)
-------
Cadnium
7WO-43-9
ca
a
t» 112.40, NP 321 C, BP 765 C, VP 1 gm Hg at 39<4 C, 10 mm Hg at 186 C
(CONTINUED)
TISSUE
6198
Trachea
61 99
Urine
6200
Urine
EXPOSURE ROUTE
ANALYTICAL
METHOD
ES
AAS
NUMBER
OF CASES
2
a) 66
b) 23
c) 59
1
RANGE
Not given
a) 0. 65 -61. 6 ug/g
b) 4.23-U6.3 ug/g
creatinine
c) 0.33-12.3 ug/g
creatinine
Not applicable
(NEXT
HEAN
0.95 +or- 0.22 ppm
dry wt
a) 13.8 + or — 1.36
b) 21.1 +or- 2. 34
uy/g cr eat mine
c) 3. 1 +or~ 0. 34 ug/y
creatinine
14.4 ag/g cretinine
PAGE)
GENERAL INFORHATICN
normal tissue
Autopsies
Japan
JAPAN; ADUtTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYFPH MODES; PANCREAS; SPLEEN;
STOMACH; THYROID GLANDS; TRACHEA;
MIHIHC1*; BAfiiaB; CADHH3H; CALCIOH;
CtiROniUW; COBALT; COPPER; IRON; LEAD;
MAGNESIUM; MANGANESE; HETALS;
PCLYBDENUH; NICKEL; PHOSPHCBOS ;
EOTASSIUM; SILICON; SILVER; SODIUM;
STRON1IOM; TIN; TITANIUM; VANADIUM;
ZINC; BIOACCOHULftTICH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGOE; ZIRCONIUM; ELEMENTS
c) Noa-Cd workers at saae Zn-Cd plant
Mean employment period 17 {a), 27 [b)
and 18 yr (c) . Mean exposure period
7.5 (a) and 21.2 yr (b) . Exposure
levels 168 ug/cu m (static sampler)
or 1 192 ug/cu a (personal air
ncnitor) foe a) and b) , and 0. 1-15
ug/cu m foe c)
148 of 264 workers with liver and
renal cortical Cd levels atove
detection limits (10 and 50 ppa.
respectively)
Good correlation with body burden
Active and retired workers at Zn-Cd
plant, Belgium
Renal dysfunction unlikely if urine
level of 10 uq/g creatinine (180 ng
body burden) is not regularly
exceeded. Critical liver level 30-60
215-38? ppa
BELGIUM; ADOLTS ; KIDNEY DISEASES;
BLOOD; BODY; KIDNEYS; LIVER; URINE;
IB VIVO ANALYSIS; CADHIOH; HETALS;
HEALTH HAZARDS; INDOSTRIAL
ATMOSPHERES; INHALATION; OCCUPATIONAL
HAZARDS; SMELTERS
37 yr old worker, Ni/cd battery
factory
g n r 1 ular p
BIOOD; KIDNEYS; LIVER; OHINB; DSITED
KINGDOM; CADHIOH; HETALS; INDOSTRIAL
CLANTS; OCCUPATIONAL HAZARDS;
FCPOLATION EXPOSURE
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36 (H) • 155-165
Buchet, J.P.
Bernard, A.
Chettle, D.R.
Harvey, T.C.
Al-Haddad, I. K .
1981
26:217-240
Ghose, R.R.
Sorgan, H.D.
Cumiios, P.E.
1981
British Journal of
38: 185-186
-------
Cadnium
7*110-43-9
ca
Attf 112.140, (IP 321 C, BP 765 C, TP 1 mm Hg at 3914 C, 10 •• Hg at 486 C
(CONTINUED)
TISSUE
6201
Urine
Urine
6203
nrine
EXPOSUPE BODTE
_
_
ANALYTICAL
BETHOD
AAS
AAS
NtJBEEB
OF CASES
16
a) 39
b) 42
C) 43
BANGE
a) <0.5-6.5 ug/1
t>) 10-32 ug/1
c) 7.3-21 ug/1
a) 1.95-11.80 ug/g
creatimne
b) 1.3-29.t» ug/g
creatinine
c) 1.0-3.1 ug/g
creatinine
HEAN
a) Not given
b) 20.2 +or- 10.it
ug/1
c) J4.5 +or- 5.8 ug/1
iven
a) Hot given
D) Not given
c) Not given
GEHEBAL INFORMATION
a) 11 subjects, exposed 1.8-12 BO
b) 5 subjects, exposed 3-19 yr
c) Same as b) , 2 yr later
Workers, Cd-pignent manufacturing
plant, Australia
Dyspnea, esphyseia
£1000; ORINE; AUSTRALIA; CASE
HISTORIES; INDUSTRIAL DISEASES;
CADMIOH; HETALS ; INDDSTRISL PLAHTS;
OCCUPATIONAL HAZARDS; POPULATION
EXPOSURE
exposure, flean level during exposure
75 ug/1
Patients with proteinuria following
KIOSET DISEASES; UNITED KIHGDOn;
AC01TS; OCCOPATIOBAL DISEASES; OP.IHE;
ISDOSTFIAL BEDICIBE; CADBIDB
a) Workers at Hi-Cd fcattery plant.
average workplace tine 1.5 yr
fc) Workers at Zn-Cd smelter, average
time K.5 yr
c) Controls, nedian 1.9 ug/g
creatinine
?-95 percentile range
GERBAST; ADULTS; BLOOD; UHIHE;
CCBPABATIVE IVALOATIOSS; ISDOSTEIAL
BECICISE; CADBIOB; LEAD; BEBCDP.I;
UTALS; PKOTEIHS; HEALTH HAZAEDS;
IBDOSTKIAL PLAHTS; OCCUPATIONAL
HAZARDS; SBELTE8S
BEFEEENCE
De Silva, P.E.
Donnan, B.B.
1981
British Journal of
Industrial Bedicine
38:76-86
1981
Lancet 1(8224) :845
Schaller, K.H.
Gonzales, J.
Thurauf, J.
Schlele, B.
1980
Zentralblatt fuer
Bakteriologie,
Parasitenkunde,
Infektionskrankheiten
und Hygiene, Abteiluug
1. Originale, Reibe B.
Hygiene, Preventive
Bedizin 171:320-335
-------
Calcian
70110-70-2
Ca
Atw UO.08r
RF 850 C, BP 1"t»0 C, VP 10 nc Hg at 983 C
TISSUE
620U
Adrenal
gland
6205
Aorta
6206
Blood,
plasma
1
1
1
1
EXPOSURE POQTE
Ingestion
ANALYTICAL
HETHOD
ES
SS
AAS
SDH BEE
OF CASES
7
7
2
! BiSGE
Not given
Not given
a) Bot applicable
b) Bot applicable
c) Hot applicable
d) 8.8-9.0 mg/100 ml
BEAK
560 +or- 430 ppm dry
wt
7700 +or- 4200 ppm
dry wt
a) 8.8 »g/100 ml
0) 9.6 mg/100 ml
c) 8.8 mg/100 ml
d) Not given
I GESEE&L BiFOHMTICN
[
Normal tissue
S utopsies
Japan
TCNGOE; ZIRCONIOH; ELEBENTS; JAEAB;
ACOLTS; AOTOPSIES; ADREBAL GLANDS;
AORTA; BOBES; HEAET; IHTESIINES;
KIDNEYS; LUES; LOBGS; LYBEH BODES;
SPLEEN; PAHCSEAS; STOBACH; THYROID
GLANDS; TRACHEA; ALOHINUB; BARIOB;
CADBIOH; CAtCIDB; CHROBIDB; COBALT;
CCPPEE; IRON; LEAD; HAGNESIOB;
BAHGABESE; BETALS; BOLYBDEBOB;
NICKEL; EKOSEHOBOS; 9OTISS30B;
SILICON; SILVER; SODI0H; S1RONTIUH;
TIB; TITABIOfl; TABADIOB; ZINC;
EIOACCUBULATIOB; HEALTH HAZARDS;
OCCOPATIONAt HAZARDS
Normal tissue
Autopsies
apan
TONGUE; ZIBCOBIOB; ELEBSNTS; JAPAN;
ADOLTS; AUTOPSIES; ADBEBAL GLANDS;
AOBTA; EONIS; HEART; INTESTINES;
KIDN3YS; LIVER; LONGS; LYflPH BODES;
SPLEEN; PABCEEAS; STCBACH; THYBOID
GLANDS; TRACHEA; ALUBIHOB; BARIUH;
CADBIOH; CA1CIOB: CHROBIOB ; COBALT;
CCPPEE; IEON; LEAD; BAGNESIOH;
BANGABESE; BETALS; BOLYBDENOB;
NICKEL; PHOSPHORUS; POTASSIOB;
SILICON; SIIVEE; SODIDfl; S1RONTIOH;
TI»; TITABIOn; 7ASADHIIC, IIHC;
BIOACCOBOLATION; HEALTH HAZARDS:
CCCOPATIONSL HAZABDS
a) Subject 1, beginning of study
b) Subject I, intake 733 »g/24 hr.
low fiber diet
c) Subject 1, intake 780 mg/24 hr.
high fiber diet
d) Subject 2, fluctuation during
study period, intake 772 ng/24 hr low
fiber diet, 841 ig/2« hr high fiber
diet
Total dietary intake dnring two 20
day study periods vith 50% of caloric
intake from either white bread or
local, high fiber, moderate phytate
bread.
35 and 24 yr old, vt 56.0 E 60.3 kg.
Iran
I8AH; ADOLTS; SUTBITIOHAI.
DEFICIENCIES; BLOOD PLASBA; BLOOD
SE5UB; OBINE; CAICIOB: BAGNESIOB;
IHCSPHORUS; ZINC; DIETS; FIBERS;
FOODS; HETAIS
EEFEPEBCE
Teraoka, H.
1981
Archives of
36 (4) : 155-165
Teraoka, H.
1981
Archives of
36(4) : 155-165
Beinhold, J.G.
Farad ji, S.
Abadi, P.
Ismail-Beigi, P.
1976
Journal of Nutrition
106:493-503
(BEIT PAGE)
KJ
-------
Calcium
71400-70-2
At« 10.08, BP 650 C, BP 1440 C, VP 10 III Hg at 983 C
(CONTINUED)
TISSOE
6207
Flood,
plasma
6208
Blood,
serum
6209
Bone
EXPOSURE SOtJTE
ANALYTICAL
METHOD
AAS
AAS
ES
NOHBEE
OF CASES
a) 20
b) 20
a| 26
b) 21
c) 52
d| 11
e) 10
f] 21
q) 10
h) 10
i| 10
._
5
RANGE
a) Not given
b) Not given
a) Not gi en
b) Mot gi en
c) Not gi en
d) Not gi en
e) Hot gi en
f) Not gi en
g) Not gi en
h) Not gi en
i) Not gi en
Not given
SEAN
a) 2.3 »or- 0. 16
unol/1
b) 2.3 tor- 0.2
amol/1
a) 86 o - 6 ppm
b) 81 o-1 ppm
c) 86 o-9 ppm
d) 85 0-2 ppm
e) 88 0-0.5 ppm
f) 90 0-8 pp»
g) 87 0-0.4 ppm
h) 90 0-6 ppjn
i.) 130 + r- 38. 1 ppm
92000 tor- 9200 ppm
dry wt
GENERAL INFORBATION
a) Ltiited care dialysis patients
b) Hone dialysis patients
Clinically stable patients on
intermittent dialysis >9 icnths
HEBODIJIYSIS; KICKBr DISEASES;
CALCIOB; BETALS; PHOSPHOBDS; BLCOD;
B1COD PlASnj; ALOBINOB
a) Lung and respiratory tract
b) Gastrointestinal tract
c) Breast
d) Cervir
e) Lynphatic leukeaia
f) Balignant selano as
<;) HodgVin*s lynpho a
h) Healthy voluntee s
i) Geriatric patien s
a) -g) type c£ cance
fcl, cl , and d) significantly lower
than h) and i)
Cancer patients (15-81 yr olds).
geriatric patients (65-81 yr olds) ,
healthy volunteers (20-DH yr olds) ,
UK
UNITED KINGDOM; CSBCINOBAS; LEOKEBIA;
BEIANOBAS; SEOPLASBS; SARCCBAS; BLOOD
SJP01; CHLCIOB; CCPPEB; fl»GNESII)B;
BABGANESE; BETALS; ZINC;
EICINDICATOBS
Normal tissue
Autopsies
Japan
10NGDE; ZIECONIOM; ELEBESTS; JAPAN;
ACDLTS; AOTOPSIES; ADEENAL GLANDS;
ACETA; BONES; HEART; INTESTINES;
KID1IETS; LITER; LONGS; LTBEH NODES;
SELEEN; PANCEEAS; STOBACH; THYROID
GIAHOS; TEACHEA; ALDalNOB; BAEIUfl;
CABBIOB; CALCIOB; CHaOBIOB; COBALT;
COPPEE; IBOS; LEAD; BAGNESIDB;
BANGANESE; BETALS; BOLJBDENOB;
NICKEL; PBOSPHOP.OS; POTASSIUB;
SILICON; SILVER; SODIOfl; STBONTIOH;
TIN; TITANIOB; VAHADIHH; ZISC;
EIOACCnBOLATION; HEALTH HAZAEDS;
OCCDPATIOBAL HAZAEDS
REFERENCE
Zu Ilk ley, H.
Bertraa, H.P.
Graefe, tl.
Langer, K.
1980
Proceedings, University
of Missouri Annual
Conference on Trace
Substances in
114:299-303
Capel, I.D.
Pinnock, H.H.
ailliams, D.C.
Hanhan, I.W.F.
1982
oncology 39:38-4 1
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
(NEXT PAGE)
-------
Calcium
7H40-70-2
Ca
AtW "40.08, HP 850 C, BP 1UUO C, IP 10 Hi Hg at 983 C
(CONTINUED)
I TISSUE
1
6210
Bone
6211
Heart
6212
Intestine
EXPOSURE POUTS
ANALYTICAL
METHOD
ns
ES
ES
NOHBEE
OF CASES
a)
t>)
c)
a)
e)
f)
a) 6
b) 2
c) 3
d) i
e) 1
10
RANGE
a) Not applicable
b) Not applicable
c) Not applicable
d) Not applicable
e) Hot applicable
t) Not applicable
a) Not given
b) 1400-2100 ppm
c) 190Q-UOOO ppm
d) Not applicable
e) Mot applicable
Dry wt
Hot given
MEAN
a) 24X
b) J5J6
c) 25*
d) 23%
e) 26*
f) 31%
Dry wt
a) 660 '+or- 530 ppni
b) 1750 ppa
c) 2767 ppa
d) 2200 ppm
e) 1100 ppm
Dry wt
wt
GENERAL INFORMATION
a) Maii^u.le, Hauca Negca site.
recently exposed, pre- ceramic.
pte-Bet t 1 lurgical, date 4500-3000 yr
before crenent (bp)
fc) Femur, Guanape cemetery, speci»ens
exposed on surface 30 yr.
post -ceramic, pro to -metallurgical.
date 3000-2500 yr bp
c) Bandible, Hauca Gallina7o site.
metallurgical, date 2000-1100 yr bp
d) Nandible, another person, site c)
e) Mandible, another person, site c)
f) Vertebra, DUBE; of wealthy fenale
Egyptian, Ptolemic period, 2200 yr bp
Peruvians was 3X10(E-8), compared to
2100-3500T10 (E-8) in bones of
present-day residents of England and
the United states
present-day Americans
Egypt
EGYPT: PERU; OHITED KINGDOH; HUTTED
STATES; BONES; TEETH; BARIDH;
CSICIUM: LEAD; BIOACCO MULATTOS
a) Normal healthy Men
b) Chroniua plating worker
c) chroaate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
TCHGDE; ZIRCOHIOII; ELESENTS; JSPAH;
AEOLTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BOBES; HEART; INTESTINES;
KIDNETS; LIVEE; LUNGS; LYBSH MODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLANDS; TRACHEA; kLURIHUH; BARIUH;
CADBIUB: CALCIUII; CHROBIUB; COBALT;
COPPER; IRON; LEAD; HAGNESIUH;
BANGANESE; SETALS; BOLIBDEIUB;
SICKEL; EHOSEHOSOS; EOTISSIUH;
SILICON; SILVEB; SODIUB; S1HOHTIUB;
TIN; TITiNIOfl; TSBADIDS; ZINC;
BIOACCUnULATION; BEilTH HAZARDS;
OCCUPATIONAL HAZARDS
Autopsies
Japan
TONGOE; ZIRCOmDM; BLEHESTS; JAPAS ;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BONIS: HEART: INTESTISES;
KIDNEYS; LIfER: LUNGS; LYHPH NODES;
SPLEEN; PANCKEAS; STOBACH; THYROID
GLANDS; TRACHEA; 1LUBIHUB; BABIOB;
CADBIUB; CALCIOB; CHEOBIDH; COBALT;
CCPPER; IRON: LEAD; HAGNESIUB;
BANGANESE; BETALS; BOLYBDEIUB;
SICKEL; PHOSPHOROS; POTASSIUB;
SILICON; SILVER; SODIDB; STBCNTIUB;
TI»; TITANIOfl; T»N»DIDB; ZINC;
BI01CCUKDLATION; HEALTH HAZARDS:
OCCUPATIONAL HAZARDS
REFERENCE
Ericson, J. E.
Shirahata, H.
Patterson, C.C.
1979
New England Journal of
Bedicine
300(17) :9U6-951
Teraoka, H.
1961
Archives of
36(4) :155-165
Teraoka B*
1981
Archives of
Environmental Health
36(1) : 155- 165
(NEXT PAGE)
-------
Calciun
7440-70-2
Ca
At» ltO.08, BP 850 C, BP 1110 C, VP 10 HI Kg at 983 C
(CONTINUED)
TISSUE
6213
Sidney
6211
liver
6215
lung
EXPOSURE BODTE
ANALYTICAL
BETHOD
ES
IS
ES
NUB BEE
OF CASES
a) a
b> 2
c) 3
d) 1
e| 1
a] 9
b) 2
c| 3
d) 1
e)
a) 12
b) 2
c) 3
d) 1
e) 1
RANGE
a) Not given
b) 1700-3100 ppm
c) 2200-4100 ppm
e) Hot applicable
Dry wt
a) Hot given
b) 1400-2500 ppm
c) 2500-4700 pp»
d) Not applicable
Dry wt
a) Not given
b) 1700-1900 ppm
c) 1900—13000 ppm
d) Hot applicable
e) Not applicable
Dry wt
1
BEAN
a) 1500 +or- 1200 ppm
b) 2400 ppm
c) 3367 ppm
e) 1000 ppm
Dry wt
a) blO *or- 380 ppm
b) 1950 pp»
c) 3667 ppm
3.) 2300 ppm
Dry wt
a) 1300 + or- 860 ppm
b) 1800 ppm
d) 2400 ppm
c-1 850 ppffi
n j wt
GENERAL INFOEIIATIOK
a) Normal men
b) Chromium plating workers
c] Chromate refining workers
e) Stone Bason
Autopsies
Japan
TCNGtJE; ZIBCONIOH; ELEBENTS; JAPAN;
ADDLTS; AUTOPSIES; ADRENAL GLAHDS;
JOETA; EONIS; HEART; IPTESTINES;
KIDNEYS; LITER; LONGS; LYHPH NODES;
SPLEEN; PANCSEAS; STOflACH; THIBOID
GLANDS; TEACBEA; ALDBISOB: BARIUH;
CADniUfl; CAICIO!!; CHEOHIUB; COBALT;
COPPER; IRON; LEAD; BAGNESIOH;
HASGANSSI; HITALS; BOLTODEKDB;
NICKEL; PHOSPHORDS; POTASSIUB;
SILICON; STLVEB; SODinB; SlBOBTIDfl ;
TIN; TITANIOfl; VANADIDB; ZINC;
EIOACCUBULATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
a) Normal healthy men
b) Chromium plating workers
c) chcomate refining workers
d) Airplane painter
Autopsies
Japan
TCNGOE: ZIPCCNIUB; ELEKENTS; JAPAN;
ACULTS; AUTOPSIES; ADRENAL GLANDS;
AOBTA; EONE-i; HEART; INTESTINES;
KIDNETS; LIVEB; LONGS; LYBPH NODES;
SPLEEN; PANCREAS; STCBACH; THYEOID
GLANDS; TRACHEA; 1LDBINOB; BARIDB;
CADBIUW; CAICIUB; CHEOBIUB ; COBALT;
CCPPSR; IRON; LEAD; HAGNESIOB;
BSBGASESI; BETALS; BOLYBDENI1S:
NICKEL; EHOSPHORDS; POTASSIUB;
SILICON; SILVER; SODIOH; STRCNTIUB;
TIN; TITANIUM; VASADIUB; ZINC;
ETOACCOBOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
a) Normal men
b) Chroiriua plating workers
aj Airplane painter
e) Stone mason
A utopsies
Japan
TCNGUE; ZIRCCNIUH; ELEMENTS; JAPAN;
ACDLTS; AOTOPSIES; ADRENAL GLANDS;
ACPTA; EONIS; HEAET; INTESTINES:
K1DNEJS; LIVER; LUHGS; LYfPH NODES;
SF1EEN; PANCREAS; STCBACH; THISOID
GLANDS; TRACHEA; ALUBINUB; BARIOfl;
CSDBIOB; CALCIUB; CHEOHIOB; COBALT;
COPPER; IPON; LEAD; BAGNESIUB;
BANGANESE; BETALS; BOLYBDENU1;
NICKEL; PHOSPHORDS; POTASS10B;
SILICON; SILVER; SODIUB; STRONTIDB;
TIN; TITANIUB; VANADIUH; ZINC;
EIOACCOBOLATICN ; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
1
REFERENCE
Teraoka, H.
1981
Archives of
36(i|| : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
Teraoka, H.
1981
Environmental Health
36(M -.155-165
PAGE)
-------
Calciun
7UUO-70-2
Ca
AtH 40.08,
HP 850 C, EP 1«UO C, VP 10
Hg at 983 C
(COHTIN'JEB)
TISSUE
>216
Lymph
lode
a217
'ancceas
5218
Spleen
EXPOSURE ROUTE
ANALYTICAL
METHOD
ES
ES
ES
NUHBER
OF CASES
a) 3
b) 1
c) 3
d) 1
e) 1
5
a) 9
b> 2
c) 3
4) 1
e) 1
BANGS
a) Hot given
b) Hot applicable
c} 1300-31*00 ppjB
d) Not applicable
e) Hot applicable
Dry wt
Hot given
-
a) Sot given
b) 1400-2700 ppm
c) 1200-6200 pptt
d) Hot applicable
e) Hot applicable
Dry wt
(HEI1
HEAN
a) 1000 tor- 250 ppm
b) 2700 pp«
c) 2033 ppm
d) 2100 ppm
e) 5600 ppm
Dry wt
180 *or- 74 ppm dry
wt
a) 720 »or- 500 ffm
b) 2050 ppm
c) 3267 ppm
d) 3500 ppm
e) 730 ppm
Dry wt
PAGE)
GENERAL IHFOPBATION
a) Normal healthy Ben
b) Chromium elating worker
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
TCHGDE; ZIECOHIOH; ELE8EHTS; JAPAS;
AEOLTS; ADTOPSIES; ADRENAL G1AHDS;
AOETA; BONES; HEAEI; INTESTINES;
KIDNEYS; LIVER; LONGS; LYHEH NODES;
SPLEEH; PANCREAS; STOMACH; THYROID
GLANDS; TRACHEA; ALUBIiraH; BARIDFI;
CADHIDH; CALCIOB; CBROBIOB; COBALT;
COFPEB; IROH; LEAD; KAGNESIun;
MANGANESE; BETALS; BOLYBDEBOH;
NICKEL; PHOSPHORUS; POTASSIOB;
SIIICOK; SIIVBR; SODIOS; SIBOKTIDfl;
TIN; TITANIOB; TAHADIQB; ZINC;
BIOACCOBOLA1ION; HEALTH HAZARDS:
CCCOPATIONAL HAZARDS
Normal tissue
Autopsies
Japan
TCNGOE; ZIRCONIDB; ELEBBNTS; JAPAN;
ACOLTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BONES; BEAST; INTESTINES;
KIDNEYS; LIVER; LONGS; LYBPH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GIANDS; TRACHEA; ALOBINtJB; BARIOB;
CADHinn; CALCIOfl; CHEOBIOH; COBALT;
CCPPEB; IRON; LEAD; HSGNBSIOB;
BANGANESE; BETALS; KOIYBDENDB;
NICKEL; PHOSPHOHDS; POTASSIOB;
SILICON; SILVER; SODIDB; STRONTIDB;
TIN; TITANIOH; VASADIOH; ZINC;
EIOACCHBOLATION: HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
a) Normal men
b) Chronia* plating workers
c> chroaate refining vorkers
d) Airplane painter
e) Stone mason
Autopsies
Japan
TONGOE; ZIRCONIOB; ELEHENTS; JAPAN;
ACOLTS; AUTOPSIES; ADRENAL GLANDS;
ACRTA; BONES; HEART; INTESTINES;
KIDNEYS; LIVER; IDNGS; LYHPH NODES;
SPLEEN; PANCREAS; STOHACH; THYROID
GLANDS; TRACBEA; ALOHINOn; BAEIU1;
CADBIOH; CALCIUB; CHROHIOB; COBALT;
COPPER; IRON: LEAD: BAGNESIOB;
BANGANESE; BETALS; ROLIBDESOU;
NICKEL; PBOSPHOHOS; POTASSIUB;
SILICON; SILVER; SODIUfl; STBONTIUB;
TIN; TITANIOB; VANADIUfl; ZINC;
BIOACCUBOLATION; HEALTH HAZARDS:
OCCUPATIONAL BAZAEDS
Teraoka, H.
1981
Archives of
Environmental Health
36 («):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(11): 155-165
Teraoka, H.
1981
Archives of
Environnental Bealth
36(U):155-165
-------
Calcium
7(110-70-2
Ca
Ats 40.08,
HP 850 C, BP 1440 C, VP 10 ID Hg at 983 c
(CONTINUED)
TISSUE
6219
Stomach
6220
Teeth
6221
Thyroid
gland
6222
Tongue
EXPOSURE EODTE
ANALYTICAL
METHOD
ES
HS
.
ES
ES
SOB BEE
OF CASES
10
a) 1
b) 1
c) 1
d> 1
n
2
BINGE
Hot given
a) Not applicable
b) Not applicable
c) Not applicable
d) Not applicable
given
..
Not given
MEAN
1300 +or- 120 ppa dry
wt
a) 34*
b) 28)1
c| 34)1
d| 32!!
Dry wt
wt
700 +or- 71 ppm dry
wt
GENERAL INFOEBATIOH
Normal tissue
Autopsies
Japan
TONGOE; ZIRCONIUH; ELEMENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLAKDS;
AORTA; BOHSS; HEAHT; ISTBSTI8ES;
KIDNEYS; LIVER; LONGS; LYHPH NODES:
SE1EE8; PANCREAS: STOHACH; THYROID
GLANDS; TRACHEA; M.UBINUH; BARIUB;
CAD9IOB; CALCIU9; CHROBIUB; COBALT;
CCPPER: IRON; LEAD; BAGNESIUH;
BANGANESE; BETALS: BOLYBDENtJB;
NICKEL; PBOSPHOROS; POTASSIDB;
SILICON; SILVER; SODIOB; STRONTI'JB;
TIN; TITANIOB; VASADIOM; ZINC;
BIOACCOBOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
a) Hauca Negra site, recently
exposed, pre-ceraBic,
pre-netallurgical, date 1*500-3000 yr
before present (tp)
b) Guanape cemetery, specimens
exposed on surface 30 yr.
post -ceramic, pro to-«e tall urgical.
date 3000-2500 yr bp
c) Huaca Gallinazo site.
•etallurgical, date 2000-1KOO yr bp
d) Another person, site c)
EncMDel
Specimens from Vicu Valley, Peru
Autopsies
Japan
TCNGCTE; ZIBCONItTH; ELEBEHTS; JSPAK;
AEOLTS; AUTOPSIES; AD8EBAL GLANDS;
AORTA; BOSIS; HEABT; INTESTINES;
KIDNEYS; LIVER; LUNGS; LYBPH NODES;
SPLEEN; PANCREAS; STCBACH; THYROID
GL8NDS; TRACHEA; 1LDBISUH; BARIDB;
CADBIUB; CALCIOB; CHBOBIDH; COBALT;
CCPPER; IRON; LEAD; BAGNESII)!!;
BANGANESI; BHTALS; BOLYBDENDB;
NICKEL; PHOSPHORUS; POTASSIDB;
SILICON: SILVER; SODIUB; SIRONTIUB;
TIN; TITANIOB; VAHADIOB; ZINC;
BIOACCUHULATION; HEALTH HAZARDS;
OCCtJPATIOKAL HAZAGDS
Normal tissue
Autopsies
apan
TCNGUE; ZIECOBIOfl; E1EBENTS; JSFA8;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
JOPTA; BOKIS; HEART; IHTBSTIKES:
KIDNEYS; LIVER; LONGS; LYBPH NODES;
SPLEEN; PANCREAS; STOBACB; THYROID
GLANDS; TRACHEA; &LDBISDB; BARIUB;
CADMIDB; CALCI0B; CHROHIUB; COBALT;
COPPER; IRON; LEAD; BAGNISIUB;
BANGANESE; BETALS; BOLYBDENUB;
NICKEL: PHOSPHOBUS; POTASSHIfl:
SILICON; SILVER; SODIUB; S180BTIUB;
TIN; TITANIOB; VAUADIUB; ZIIIC;
BIOACCnflDLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
REFERENCE
Teraoka, B.
1981
Archives of
Environmental Health
36(41:155-165
Ericson, J.E.
Shirahata. H.
Patterson, C. C.
1979
New England Journal of
Bedicine
300(17) :9K6-951
1981
Archives of
Environmental Health
36(4) :155-165
Teraoka, H.
1981
Archives of
36(4) : 155-165
(NEXT PAGE)
-------
calcium
7440-70-2
Ca
Atw 40.08, HP 850 C, BP 1440 C, VP 10 mm Hg at 983 C
EXPOSURE BOOTE
(CONTINUED)
6223
Trachea
6224
TJrine
Ingestion
ncAi
10D
NOHBEB
OF CJSE5
2
2
RANGE
Not given
a) Not given
b) Not given
c) Not given
d) Not given
BEAU
5000 + or- 2500 ppn
dry wt
a) 154 «g/24 hr
b) 99 mg/24 hr
c| 187 mg/24 hr
d) 12B mg/24 hr
GENERAL INFOBBATION
Normal tissue
Autopsies
Japan
TONGUE; ZIECONIUB; ELEBENTS; JAPAN;
AEOT.TS; AUTOPSIES; ADBENAL GLANDS;
AOBTA; EOBES; HEABT; INTESTINES;
KIDNEIS: LIVEB; LONGS; IIBPB NODES;
SFIEEN; PANCBEAS; STCBACH; THIBOID
GLANDS; TBtCBEA; ALUBIBDB; BABIOB;
CADfllOB; CALCIUB; CHROBIUn; COBALT:
CCPPER; IEON; LEAD; BAGKESIOB;
BANGANESE; BETALS; BOLIBDEItIB;
NICKEL; PBOSP808US; POIASSIOB;
SILICON; SILVEE; SODIOB; STBONTinn;
*IH; TITANIUH; VAKADIDB; ZINC;
BIOACCUPULATION; HEALTH HAZARDS;
OCCUPATIONAL HJZABDS
a) Subject 1, intake 733 ig/24 hr,
lew fiber diet
fc) Subject 1, Intake 784 >g/2
-------
Carbanilide, trichloro- (8 CI)
Urea, N,N'-diphenyl-, trichloro deriv. (9 CI)
1332-40-3
C13-H9-C13-N2-0
B» 315.6
(CONTINUED)
TISSUE
6226
Orine
EXPOSURE ROUTE
Ingestion
ANALYTICAL
METHOD
Radioaetry
HPLC
_
NUMBER
OF CiSES
6
RANGE
22. 7-41 X of labelled dose
BEAN
27.0 +or- 2. 8S o£
labelled dose
S.E.
GENERAL INFORBATICN
Maxiaua cumulative excretion 80 hr
after 1.9-2.1 UBJl/kg
Healthy 20-(|0 yr olds
ADULTS; BLOOD PUSH 4; UHI»E;
COSMETICS; METABOLITES ; BADICISOTOPES
BEFERENCE
Riles, R.A.
Birch, C.G.
1978
Drug Metabolisa and
Disposition
6(2) : 177- 183
_
arbon disulfide
5-15-0
-52
B 76.ID, HP -110.8 C, BP 06.5 C, VP 400 Dm Hg at 28 C
TISSUE
Urine
EXPOSURE ROUTE
ANALYTICAL
flETHOD
NUHEER
OF CASES
RANGE
creatiaine
creatinine
creatinine
d) 5.7-6.2 nool/iiol
creatinijie
e) 6.1-13.14 mnol/nol
creatinine
creatioine
BEAN 1 GEHHEAL IHFOBHATION
b) Not applicable
d) Not applicable
£) Not applicable
to CS2, 69 saiples
process spinning, 56 saaples
process spinning, 78 samples
d) Vorkers exposed to 10 ag CS2/CU •
at plant 8, 6 sacples
e) Workers exposed to 50 ig C52/CU •
at* plant B, 12 saaples
at plant B, 60 saiples
Total valid samples. Levels for
pre-vorkshift and end of vorkshift.
Reasured as thio coKpoands
(letabolites)
Range of Beans
Rayon plant workers. The Netherlands
HETRERLANDS; DRINE; CARBON INORGANIC
COMPOUNDS; SDLFOB; INDUSTRIAL
ATMOSPHERES; INDUSTRIAL PLANTS;
INHALATION; BETAEOLITES; OCCUPATIONAL
HAZARDS
REFERENCE
Leijdekkers, C.P.M.J.fl.
Vanhoorne, M.
1981
Archives of
Einrir-oniental Health
36(61:289-297
. _
VO
Carbon nonoxide
630-08-0
C-o
BW 28.01, BP -205 C, BP -191.5 C, VP 10 ma Hg at -215 C, 100
Hg at -205.7 C
6228
Blood
EXPOSURE ROUTE
Inhalation
ANALYTICAL
METHOD
NUBBEB
OF CASES
a) 104
b) 144
c) 1
d) 1
RANGE
a) 0.05-2.00 al/dl
b) 0.10-1.70 al/dl
c) Hot applicable
d) Sot applicable
BEAN
a) Not given
b) Not given
c) 0. 130 »or- 0.0066
ml/dl
d) 1.303 *or- 0.022
ml/dl
GENERAL INFORMATION
a] Vortex aethod. Smokers and
nonsaokers exposed to various levels
of CO to produce range of expected
carboxyheaoglobin values
b) Hanometric aethod. Exposed as in
a)
c) Nonsaoker
d) Saoker
c), d) mean of 10 determinations
CARBON MONOXIDE; BLOOD; MEASUREMENT
METHODS; CABBON INORGANIC COMPOUNDS;
S COKING
REFERENCE
Dahas, T.E.
Borvath, S.M.
1974
Clinical chemistry
20(5):533-537
-------
Carotenes and Cacotenoids
36-88-H
EXACT COMPOSITION UNKHOHN OB UNDETERMINED
TISSUE
6229
Blood,
serub
EXPOSDKF. BODTE
A»JLYTICAL
METHOD
HDBBER
OF CASES
6
BARGE
a) 1.50-6.90 ug/ol
b| 1.60-6.10 ug/nl
BEAN
a) 3. 88 +or- 1 .00
IU/B1
b) 3.70 tor- 0.90
IU/»1
GENE8SL INFORMATION
a) Before hemodialysis
b) After 8 hr hemodialysis
Ncrnal level, (1.93 ug/nl
No significant change after
hemodialysis
Patients with chronic uremia
C8ROTINOIDS; KIDNEY DISEASES; BLOOD
SEPOB; HEnODHLYSISj VITAMIN A:
ISRAEL
REFERENCE
Gotloib, L.
Sklan, D.
Bines, B.
1978
Journal of the American
fledical Association
239(8) :751
Cesiui
7UUO-H6-2
CE
AtW 132.905K, HP 28.5 C, BP 705 C, »P 1 l> Hg at 279 C, 10 M» Hg at 373 C
TISSDE
6230
Hair
6231
Nail
EXPOSURE POOTE
ANALYTICAL
BETHOD
NA
HA
HOBBER
OF CASES
30
35
BANGS
5-32 ng/g
16-72 nq/q
fiEAN
Not given
Not given
GEKF.BAL INFORHATIOB
Range of means, estimated fro graph
Aswan, El Kharga, Assuit, Cairo, and
Alexandria, Egypt
EGYPT: HAIR: SAILS; ANTIBONY;
IBON; BAHGANF.SE; HETALS; BOLYBBENDB;
SCANDTOB; SBLEHIDH; SILVER; TONGSTE»;
ZINC; DRINKING HATEE; POPDLATIOK
EXPOSORE; SOUS; OBBAK AREAS
P.ange of means, estimated from graph
Alexandria, Egypt
EGYPT; HilR; BAILS; 1NTIBOHY;
caimiDfl; CESiofl; CHROHIOB; COBJLT;
IKCN; fliNGJNESE; BETALS; BCLYBPENOB;
SCABDIOK; SELEBIOB; SILVER; TOSGSTEII;
ZINC; DRINKIHS WATER; POPOLATION
EXPOSOBE; SOILS; URBAN AREAS
REFERENCE
Kasperek, K.
lyengar, G. V.
Feinendegen, L.E.
Hashish, S.
Bahfouz, fl.
1932
Environment 22:1U9-168
Kasperek, K,
lyengar, G. V.
Hashish, S.
nabfouz, H.
1982
Science of the Total
EDvironBent 22:149-168
-------
Chlorine
7782-50-5
CI
AtH 35.753, HP -101 C, BP -31.05 C, TP 1800 mi Hg at 20 C, 1 mm Hg at -123 C
TISSUE
6232
Hair
EXPOSURE ROUTE
_
A8ALYTICAL
BETHOD
HA
NUHBER
OP CASES
_
BADGE
a) 52-2280 ppm
b) 31-1510 ppm
c) 47-992 ppn
BEAK
a) 532 tor- 151 ppm
b) 172 tor- 132 pp.
c) 217 tor- 228 ppm
GEBEBAL IBFOR BATICB
a) 12 cm length, 91 samples
b) Boot section, 18 samples
c) Distal section, 18 samples
Metropolitan Bombay, India
INDIA; ADOLESCEBTS; ADOLTS; HA1S;
ANTinOHY; ARSEBIC; BBOIIIBE; CADBIUB;
CBLORIBE; C8ROBIUB; COB1LT; COPPEB;
GOLD: IODIBE; IRON; LABTHABUB;
BABGABESE; POTASSIUB; SCAB0IUH;
SILEBIUB; SILVER; SODIUH; ZIBC; AIB
lOLLOTIOfi; BIOACCOBDIATIOH; FOSSIL
FOELED POWER PLAHTS ; IHDUSTRIAL
AFEJS: IBDdSTEIAL ITBOSPHEBES;
IBDnSTBIAL EBISSIOHS: IBDUSTEIAL
POILUTIOS; POPULATIOS EXPOSORE; ORBAH
AREAS; IKDUSIKIAI CBBBICALS
REFEREIICE
Bhat, K.R.
Aranachalaa. J.
YegnasubramaDian, S.
Gaogadharan, S.
1982
Science of the Total
Environment 22:169-178
Chloroform (8 CI)
flethane, trichloro- (9 CI)
67-66-3
C-H-C13
BB 119.39, HP -63.5 C, VP 100 urn Hg at 10.« C
TISSUE
6233
Bilk
_
EXPOSURE KOUTE
ANALYTICAL
HETHOfr
GC/HS
NOBBEE
OF CASES
H2
Lisas
a) Hot detected- 1.3 ng/ml
b) 1.7-65 ng/«l
c) 0.6-6.7 ng/ml
d) 0.3-21 ng/»l
e) 5.0-12 ng/ml
f) Hot detected-65 ng/ml
BEAN
a) 0.52 +oc- 0.48
ng/»l
b| 23. 3U *or- 21.3
ng/nl
c) 1.53 *or- 1.74
ng/»l
4) 3.09 *or- 6.34
ng/ml
e) 7.21 *or- 3.55
ng/ml
£) 5.57 tor- 10.9
ng/ffll
GEMERAL IHFORHJ1TIOH
a) Bayonne, NJ, 6 sanples
fc) Jersey City, HJ, 5 samples
c) Pittsburgh, PR, 12 saiples
d) Baton Rouge, LA, 10 sanples
e) Charlestcn, H¥, 9 sanplcs
£) Total a) -c)
Due to small sample size and
FC Brand on sanpling, da ta cannot be
extrapolated to entice population
Study measured environnental
pollutants in illk, evaluated using
nilk in pollutant studies near
chenical ma
industrial
data, D.S.
For additio
Environment
Exposure Ev
ufacturing plants and/or
acilities. Additional
nd foreign, reviewed.
al infor»ation contact
1 Protection Agency,
luation Division, Office
of Toxic Substances, Washington, DC
20161
lactating volunteers, residing in
area >12 mo, no travel out of area
daring preceding vk
LODISIAHA; NES JERSEY; PENNSYLVASIA;
BEST VIP.SIHIA; ADULTS; BILK;
BEASDREBENT BETBCDS; BE8ZESES;
CBLOBIBATED HYDBOCARBODS;
CBLOROBEHZtHES; DDE; ISDUSTRIAL
ABEAS; ISDUSTBIJI EMISSIONS;
IACTATION; PESTICIDE RESIDUES; URBAB
AREAS; IBDUSTRIAL CBEBICALS; SOLVENTS
Erickson, B.D.
Harris, B.S.H., III
Pellizzari, E. D.
Tomer, K.B.
waddell, R.D.
Bhitaker, D.A.
1980
EP4 560/13-80-029, 153
pp.
-------
Cholesta-5,22-dien-3beta-ol (8 CI)
ChoVesta-5,22-aien-3-ol, (3beta)- (9 CI)
566-89-2
C27-B44-0
MB 381.71
623H
Blood,
cells
6235
Blood,
plasma
EXPOSURE ROUTE
Ingestion
Ingestion
ANALYTICAL
METHOD
TLC
GC/MS
TIC
GC/HS
NUMBER
OF CASES
1.3-2.7 ug/g
1.0-18.5 ug/il
2.2 ug/g
6.4 ug/il
GEBEBAL INFORMATION
Total noncholesterol sterols in diet,
393 »g/day for 3-1 vk (2 subjects) or
8 «k (1 subject). Total sterols in
3iet, 634 «g/day
2 nonal men, one 66 yr old
hypercholesteroleaic voman
ACDLTS; BLOOD PI ASM*; ERYTBROCTTES;
CBOLESTEROLS; DIF.TS; FOODS
Total noncholesterol stecols in diet,
282 nq/day for 3-1 «k (6 sablects) or
393 ng/day for 3-1 vk (2 subjects) or
8 vk (1 subjects). Total sterols in
diet, U<47 ngyday or 634 ng/day
6 normal 23-47 yr old Ben, 1
hypercholesterolenic 66 yr old voian
•EDITS; BLOOD PL»SB»; ERTTBROCTTES;
CHOLESTEROLS; DIETS; FOODS
Connor, W.E.
Lin, D.S.
1981
Gastroenterology
81;276-28«
Connor, v.E.
Lin, D.S.
1981
Gastroenterology
81:276-28*
Cholesterol (8 CI)
Cbolest-5-en-3-ol (3beta)- (9 CI)
57-88-5
C27-B46-0
(IB 386.6», BP 118.5 C (anhydrous), BP 233 C at 0.5 u Bg, 360 C at 760 mm Hg (soae decoup)
TISSUE
6236
Blood,
cells
6237
Blood,
plasma
EXPOSURE ROUTE
Ingestion
Ingestion
ANALYTICAL
HETHOD
TIC
GC/SS
TLC
GC/flS
NUMBER
OF CASES
3
9
..
RANGE
898-987 ug/g
1346-4287 ug/ml
948 ug/g
2076 ug/ml
GENERAL INFORMATION
Total noncbclesterol sterols in diet,
393 mg/day tor 3-4 «X (2 subjects) or
8 vk (1 subject). Total sterols in
diet, 634 ig/day
2 nonal men, one 66 yr old
hypercholesterolemic voman
ADULTS; BLOOD PLiSBA; EPYTHROCTTES;
CBOLESTEROLS; DIETS; FOODS
Total noncholesterol sterols in diet,
282 mg/day for 3-4 vk (6 subjects) or
393 mg/day for 3-4 vk (2 subjects) or
8 vX (1 subject). Total sterols in
diet, 447 ig/day or 634 mg/day
8 normal 23-47 yr old men, 1
bypercholesterolemic 66 yr old woman
ADULTS; BLOOD PLiSDA; ERTTBROCITES;
CBOLESTEBOLS; DIETS; FOODS
Connor, V.E.
Lin, B.s.
1981
Gastroenterology
81:276-284
Connor, H.E.
Lin, D.S.
1981
Gastroenterology
81:276-284
-------
Chromium
7MO-H7-3
Cr
AtH 51.996,
HP 1900 C, BP 2612 C, VP 1 mm Bq at 1616 C. 10 » Hq at IStO C
TISSUE
6238
aorta
6239
Blood
Pone
Hair
EXEOSOBE ROUTE
Dermal
ANALYTICAL
HETHOD
ES
AAS
SDMBEB
OF CASES
7
1
£AHGE
Not given
a) Hot applicable
b) Not applicable
Not given
ug/g
BEAS
3.2 *or- 2.8 ppm dry
wt
a) 220 ug/100 ml
b| 110 ug/100 ml
given
SENEBAL IHFOBBATICB
Normal tissue
Autopsies
JAPAN; ADULTS; AUTOPSIES; JDBEHIL
GLANDS; AORTA; BONES; BEAET;
INTESTINES; KIDNEYS; LIVEB ; LUNGS;
LYPPB NODES; PANCSEAS; SPLEEN;
SlOflACH; THYEOID GLANDS; TBICHEA;
JICHIBtin; B4BIOB; CAD9IUB; CJICHtri:
CBBOHIDB; CCBUT; COPPEB; IBOB; 1EAD;
HJGKESIOM; HANSAN5SE; HETAIS;
BCLYBOESni!; HICKEI; EBOSPHOBOS;
EOTASsina; silicon; SIITEB; soDinn;
STBONTItm; TIS; TITABIOB; IkSADIOfl;
ZIHC; BIOACCOBOLATICli; HEA1TB
BAZABBS; OCCOPATIOHAL HAZARDS;
TOHGDE; ZIRCOSin«; ELEBEHTS
a) 1» days after falling in vat of
chromic acia at 62 C
b) After 85 hr of peritoneal
dialysis, 8 days after accident
19 yr old industrial worker
2nd and 3rd degree burns on 20* body
surface, severe vomiting, episodes of
hypotension, complete anuria.
BETAL POISONING; BLOOD; CBBOBIUfl;
PETALS; ISDOSTBIA1 ACCIDENTS
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AOBTA; BOMBS; BEAB1;
INTESTINES; KIDNEYS; LI7EB ; LONGS;
1Y1-PB NODES; PANCBEAS; SPLEEN;
STOflACH; THYBOID CLSNDS; TRiCHEl;
AltBISUB; BABIUB; CADBIUB; CALCIDB ;
CEBOBIUB; COBALT; COPPEB; IBON; LEAD;
HAGNESIDH: BANGASESE; BETALS;
BCLY5DENDB; NICKEL; PHOSPHCBOS;
5CTASSIDH; SILICON; SILVEB ; SODIUB;
STBONTIUB; TI»; 1ITJNIOB; VANADIUB ;
ZINC; BIOACCUBUIATION; REAITB
BAZABDS; OCCUPATIONAL HAZAEDS;
TONGUE; ZIECONIU"- ELEBE»TS
Aswan, El Kharga, Assuit, Cairo, and
Alexandria, Egypt
EGYPT; BAIB; NAILS; ABTIBONY;
CADBIDB; CESIU1; CHROKIUH; COBALT;
IEON; BANGANESE; HETALS; BCLYBDENUB;
SCANDIUB; SELENIOB; SILVEB; TUNGSTEN;
ZINC; DBINKING WATEB; POPOLATION
EXPOSDBE; SOILS; DBBSN ABEAS
BEFEBENCE
Teraoka, H.
1?81
Archives of
36(11) : 155-165
Schiffl, B.
tteidmann, p.
Heiss, B.
Sassry, S.s.
1982
Bineral and Electrolyte
Betabolism 7:28-35
1981
Archives of
Environmental Health
36(<4): 155-165
lyengar, G.v.
Feinendegen, I..E.
Hashish, S.
flahfouz, B.
1982
(NEXT PAGE)
—I
u>
-------
Chromium
74UO-47-3
Cr
Atw 51.996, BP 1900 C, BP 2642 C, VP 1 mi Hg at 1616 c, 10 mi Hg at 1840 C
(CONTINUED)
TISSUE
6212
Hair
62»3
Heart
6219
Intestine
EXPOSURE ROUTE
ANALYTICAL
BETHOD
Ht
ES
ES
NUMBEH
OF CASES
a) 8
b) 2
c) 3
3) 1
e) 1
10
BANGE 1 MEAN
a) 0.09-3.3 ppm
b| 0.17-3.3 ppm
c) 0. 18-1.6 ppm
d) 0.1-1.7 ppm
a) Hot given
b) 1.5-2.9 ppm
c) 0.76-2.6 ppm
d) Not applicable
e| Hot applicable
Dry wt
Not given
a) 0.63 +or- 0.56 ppm
b) 1.03 +or- 0.97 ppm
c) 0.94 +or- 1.08 ppm
dl Q.U7 + or- 0.38 ppm
0.73 »or- 0.58 ppm
b) 2.2 ppm c) 1.5 pp«
d) 0.58 ppm
e) 0.20 ppm
Dry wt
1.3 +or- 0.89 ppm dry
at
GENERAL INFOEBATICN
a) 12 en length, 91 samples
b) Root section, 18 samples
c) Distal section, 18 samples
d) Students in a) , 24 samples
Metropolitan Bombay, India
INDIA; ADOLESCENTS; ADULTS; HAIR;
ANTIMONY; ARSENIC; BROBINE; CADMIUM;
CB10SINE; CHROMIUM; COBALT; COPPEK;
GCLD; IODISE; IRON; LABTHARUM;
MANGANESE; POTASSIDB; SCANDIUM;
SILENIUH; SILVER; SODIOB; ZISC: SIfi
POLLUTION; BIOACCOnULATIOH; FOSSIL
FUELED POSER PLANTS; INDUSTRIAL
SREAS; IBDUSTEIJL ATBOSPHEEES;
IBDOSTBIA1 EBISSIONS; IBDUSTEIAI
POIIDTION; POPDLATIOS EXPOSURE; URBAN
AEEAS; INDUSTRIAL CHEMICALS
Normal healthy men
b) Chromium plating workers
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPiH; SDDLIS; AOTOPSIBS; JDRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LJBPH NODES; PANCEEAS; SPLEEN;
STOBACH; THISOID GLANDS; TRACHEA;
AIUHINOB; BAEIOfl; CADBIUS; CALCIUM;
CEROMIUB; COBALT; COPPEE; IRON; LEAD;
MAGNESIUM; MANGANESE; BETAIS;
BOLYBDEBDH; NICKIL; EHOSPHCEDS;
POTASSIUM; SILICON; SILVER; SODIDB;
STRONTIUM; TIN; TITANIUM; VANADIUM;
ZINC; BIOACCOMULATI08; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIECONIOB; ELEMENTS
Norial tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES: PANCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TBACHEA;
ALDHINUH; BABIUM; CADMIUM; CALCIUM;
CHBOBIUB; COBALT; COPPER; IRON; LEAD;
MAGNESIUM; MANGANESE; BETALS;
BOLYBDENUM; SICKF.L; PHOSPHCBUS:
POTASSIUM; SILICON: SILVEE ; SODIDB;
S1BONTIUB; TIN; TITANIDH; V»»»BHjn;
ZINC; BIOACCUMULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGUE; ZIRCONIUM; ELEMENTS
REFERENCE
Bhat, K.F..
Arunachalam, J.
Yegnasubramaniao, S.
Gangadharan, 5.
1982
Science of the Total
Environment 22:169-178
1981
Environmental Health
36(4) : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36 (4): 155- 165
(N£XT PAGE)
-------
chromium
7440-47-3
Cr
AtS 51.996, BP 1900 C, BP 2642 C, VP 1
Hg at 1616 C, 10
Hg at 1840 C
(CONTINUED)
TISSUE
6245
Kidney
6246
liver
6247
Liver
EXPOSURE ROUTE
ANALYTICAL
METHOD
ES
ES
NA
IIUBBER
OF CASES
a) e
b( 2
d) 1
e) 1
a) 9
b) 2
c) 3
d) 1
e) 1
30
BANGE
a) Not given
b) 0.82-1.7 ppm
d) Hot applicable
e) Not applicable
Dry wt
a) Not given
b) 3.2-4.6 ppm
c) 1.0-1.5 ppm
d) Not applicable
e) Not applicable
Dry wt
0.005-0.27 ug/g
Set wt
BEAN
a) 0.45 +or- 0.42 ppm
b) 1.26 ppm
d) 0.61 ppm
e} 0. 19 ppm
Dry wt
a) 0.53 *or- 0.34 ppm
b) 3.9 ppm
c) 1.3 ppm
i) 0.41 ppm
e) 0.43 ppm
Dry wt
Not given
GBBEBAL INFOBBATION
Normal healthy men
b) Chromium plating workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAEAN; ADULTS; AUTOPSIES; ADBENAL
GIANDS; AOETA; BONES; flEART;
INTESTINES; KIDNEYS; LIVEE ; LONGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACH; TBVROID GLANDS; TEACHEA:
AICHINOn; BABIDH; CADBIUBJ C9LCIDB;
CBEOfllDB; COBALT; COPPEB; IBO»; LEAD;
BAGNESIUB; BANGANISE; BETALS;
BOLTBDESOn; »ICKEI; PHOSPHC80S;
EOTASSIUB; SILICON; SILVER; SODIUB ;
S1BOHTIUH; TIN; 1ITASIUH; VASADIOH;
?I»C; BIOACCUflUtATICN; HEA1TB
BA2ARCS; OCCUPATIONAL HAZARDS;
TONGUE; ZIKCONIOH; ELEBENTS
Normal healthy men
b) Chromium plating workers
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAFAH; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
IHTESTISES; KIDNEYS; LI7EB ; LO»GS;
IYBPH NODES; PANCEEAS; SPLEEN;
SIOBACH; TBYEOID GLANDS; TRACHEA;
ALCBINUB; BABIUB; CADBIDB; CALCIUB ;
CBSOSIUH-. COBALT; COPSES; IfiOH; LEAD;
BAGNESIOK; BANGASESE; HETA1S;
BOLYBDENUB; NICKEL; EHOSPHCBUS;
POTASSIDB; SILICON; SIL7ER; SODIOH;
STRONTIOd; TIN; TITANIU9; MNADIUB;
ZINC; BIOACCUBULATION; HEALTH
HA7ARDS; OCCUPATIONAL HAZARDS;
TCNGUE; ZIBCONIUH; ELEBENTS
Category 1 (first priority element)
as proposed by International Workshop
on Bonitorinq Environmental Haterials
and Specimen Banking
Autopsies, Baltimore, BD,
Binneapolis, BN, and Seattle, HA
BSEYLAND; BISNESOTA; WASHINGTON;
AUTOPSIES; LIVER; BEASDEEBEm
BITHODS; ALUBINUB; ANTIBONY; ARSENIC;
EARIDB; CADBIUB; CHBOBInB; COBALT;
CCPPEE; FLOCBIHB; IBOD; LEAD;
BANGANESE; "IEBCUBY; BOLYBDENUB;
NICKEL; EtJBIDIDB; SELENIUB; SILVER;
STRONTIUB; THaLLIDB; TIN; VABADIDB;
ZINC; POPULATIO9 EXPOSURE
REFERENCE
Teraoka, H.
1S81
Environmental Health
36(4) : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36 (4): 155- 165
Harrison, S.H.
Zeisler, B.
Kise, S.A.
1981
EPA 600/S1-81-025, 6
pp.
(NEXT PA3E)
-------
Chro«iuB
7HUO-in-3
Cr
AtH 51.996, HP 1900 C, BP 2612 C, VP 1 urn Hg at 1616 C, 10 «• Hg at 1810 C
(CONTINUED)
TISSOE
62D8
Lung
6219
Lynph
node
6250
Nail
EXPOSURE ROUTE
ANALYTIC*!
BETHOD
ES
ES
Hi
NOB BEE
OF CASES
a) 12
b) 2
c\ 3
d) 1
e) 1
a) 3
b) 1
c) 3
d) 1
e) 1
53
RANGE
a) Not given
b) 220-1400 ppm
c) 40-110 ppa
d) Not applicable
e) Not applicable
Dry wt
a) Sot given
b) Not applicable
c) 57-220 ppa
d) Not applicable
e) Hat applicable
Dry wt
0.95-3.25 ug/g
a) 1.4 tor- 0.70
b) 810 ppm
c) 69 ppB
d) 12 ppB
e) 2.3 ppm
Dry wt
a) 8.2 +or- 2.5 ppn
b) 2400 ppm
c) 152 ppn
d) 33 ppB
e) 4.2 ppn
Dry wt
Hot given
(NEXT PAGE)
GENERAL INFORBATION
Noraal healtby men
b) Chroiiui plating workers
c) Chrooate refining workers
d) Airplane painter
e) Stone lason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; BEART;
INTESTINES: KIDNEYS; LIVER; LONGS;
LTRPH NODES; PANCREAS; SPLEEN;
STOtlACH; THIROID GLANDS; TRACHEA;
Amniiran; BARIBBJ CHOBIOHJ CJLCIOB;
CBROHIOH; COBALT; COPPEP; IRON; LEAD;
HAGNESIOH; KANGANESE; DETALS;
BCLTBDESUa; NICKEL; PHOSPHORUS;
POTASSIUB: SILICON; SILVER; SODIUH;
STRONTIDH; TIN; TITANIDII; VANADIUB;
ZINC; BIOACCOnDLAHON; HEALTB
BAZARDS; OCCUPATIONAL HA2AEDS;
TONGUE; ZIRCONIOfl; ELEflENTS
Norial healthy Ben
b) ChroBiu* plating worker
c) Chroaate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOSTA; BONES; BEAR1;
INTESTINES; KIDNEYS; LIVER; LUNGS;
L^BPB HOBIS; EIUCBEIS; SPLIIS;
STOHACH; THYEOID GLANDS; TRACHEA;
AinniNon; BARIDD; CADHIUH; CALCIUH;
CBBOBIUB; COBALT; COPPER; IRON; LEAD;
HAGNESI09; 9ANGAIESE; HETALS;
BCLTBDENOS; NICKI1; PHOSPHCBDS;
POTASSIUH; SILICON; SILVER; SODIUfl;
STRONTIUn; TIN; TTTANIOD; ?ARADIOB;
ZINC; BIOACCUBULATION; HEAITB
B1ZARDS; OCCUPATIONAL HAZARDS;
TONGDE; ZIRCONIUB; ELEBENTS
Range of Means, estinated froB graph
Aswan, El Kbarga, Assnit, Cairo, and
Alexandria, Egypt
EGYPT; HAIR; NAILS; ANTIBONI;
CADBIUB; CESIUB; CHROBIUH; COBALT;
IRON; BANGiNESE; BETALS; BOLIBDENUB;
SCAHDItU; SELBNIOH; SILVER; IDNGSTEH;
ZINC; DRINKING HATER; POPULATION
EIPOSUBE; SOILS; OBBIS AHEAS
Teraoka, H.
1981
Archives of
Environaental Health
36 (4): 155-165
Teraoka, H.
1981
Archives of
Environaental Health
36(4):155-165
Kasperek, K.
lyengar, G.V.
Feinendegen, L.E.
Hashish, S.
Bahfoaz, B.
1982
Science of the Total
Environment 22:149-168
-------
ChromiuD
7400-47-3
cr
At" 51.996,
BP 1900 c, BP 2642 C, vp 1 »• Hg at 1616 c, 10 •* 3g at 1840 C
ETPOSORE™P00TE~
(CONTINUED)
6251
Pancreas
6252
Spleen
6253
Stomach
ANALYTICAL
BETHOD
ES
sun BIB
OF CASES
a) 9
b) 2
c) 3
d) 1
e) 1
Not given
a) Hot given
b) 1.9-4.2 ppm
c) 0.31-1.5 ppm
d) Hot applicable
e) not applicable
Dry wt
Not given
0.54 tor- 0.34 ppm
dry wt
52 +o£- 0.43 ppm
a) 0
b) 3.0 ppm
c) .94 ppm
d) 0.71 ppm
e) 0.82 ppm
Dry wt
1.3 tor- 0.89 ppm dry
»t
GENERAL INFORHATION
Normal tissue
Autopsies
Japan
JAPAN; ADULTS: AUTOPSIES; JDBENA1
GIANDS; AOBTA: BOSBS; HSART;
I»TESTI»ES: KIDHEYS; LIVBE; LOHGS:
IIHPB HODES; PiHCFEiS; SPLJEH;
S10BACH; TB1BOID G1ASDS; TE1CHEA;
ilOHIEUn; BIBIDH: CADBION; CALCIOB;
CBBONIOM; COBALT; COPPEB; IBON; LEAD;
BAG9ESIUK; BADGAHESE; BETALS;
BCIYBDENOB; HICKEL; FHOSPHCBOSj
POTASSIOS; SILICOM: SILVER! SODIOH;
SIRONTIOH; TIB; TITABIDB; VAUADIOK;
ZI8C; BIOACCOBOLAIIOSJ HEH.TH
HAZARDS; OCCDPATIOHAL BAZ1BDS;
TC1IGDE; ZIBCOSine; ELE»ERTS
Nornal healthy Ben
b) chroniun plating workers
c) chroaate refining workers
d) Airplane painter
e) Stone lason
Autopsies
Japan
JAPAN; ADOLTS; ADTOPSIES; ADRENAL
GLA'HDS; AOBTA: BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LTBPH NODES; CANCBEAS; SPLJEH;
S10HACH; THYROID SLASDSj TRACHEA:
ALDnlNOB; BAEIDfl; CADHIOM; CALCION;
CBBOBIOB; COBALT; COPPER; IRON; LEAD;
9JG»ESIOfl; 84BGAS2SZ; HETALS;
BOLTBDENOH; NICKEL; EHOSPHCSOS;
FOTASSIOB; SILICON; SILVER; SODIOB:
SIRONTIUB; TIN; TITANIOB; VANADIOB;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL BAZABDS;
TONGDE; ZIECONIOfl; ELEHENTS
Nornal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BEAR1;
INTESTINES: KIDNEYS; LIVER; LDNGS:
LYflPH NODES; PANCBEAS; SPLEEN;
SIOBACH; TBJROID SL»NDS; TBICBEA;
ALCniNDK; BA8IOB; CADBIOB; CALCIDB:
CBBOBIOB; COBALT; COPPEB; IRON; LEAD;
HAGNESIOH; BANGANESE; BETALS;
BOLYSDENUB; NICKEL; PHCSPHCBOS;
EOTASSIDB; SILICON; SILVER; SODIUfl;
STRONTIOB; TIN; TITANIOH; VANADIHB;
ZINC; BIOACCUHOL1TION; HEALTH
HAZARDS; OCCDPATIONAL HAZARDS;
TCNGOE; ZIRCOBIOB; ELEHENTS
Teraoka, H.
1981
Archives of
Environnental Health
36(4) :155-165
Teraoka, H.
1981
Archives of
Environmental
36(4): 155-165
Teraoka, B.
1981
Archives of
Environmental Health
36(4): 155-165
(NEXT PAGE)
-------
7UUO-47-3
Cr
fttW 51.996, HP 1900 C, BP 26U2 C, VP 1 mm Hg at 1616 C, 10
Hg at 1840 C
(CONTINUED)
TISSUE
6254
Thyroid
gland
6255
Tongue
6256
Trachea
EXPOSURE ROUTS
ANALYTICAL
METHOD
ES
ES
ES
HUHBEB
OF CASES
4
2
2
BANGS
Not given
Not given
Not given
HE AN
0.51* +or- 0.34 ppm
dry »t
0.62 *or- 0.42 ppm
dry wt
1.7 +or- 1.3 ppm dry
wt
GENERAL ISFORBATION
Ncrnal tissue
Autopsies
Japan
JAPAN; AD01TS: AUTOPSIES; ADRENAL
GLANDS; JOBTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVEE ; LUNGS;
LYBPH NODES: PANCREAS; SPLEEN;
SIOBACH; THYEOID GLANDS; TEICHEA:
ALnHimjB; BAEIOB: CADHIDB; CAician;
CEBOBinn; COBALT; COPPEB; IBON; LEAD;
BAGDESIOB; BANGANESE; BETALS;
BOLYBDENnfl; NICKEL; PHOSPHORUS;
POTASSIBB; SILICON; SILVER: SODIOB;
SIEONTIBH: TIH; TITASIOB; 7ANADIOB;
ZINC; BIOACCOBOLATION; HEALTH
BAZAEDS; OCCOPATIONSL HAZARDS;
TONGUE; 2IBCONIDH; ELEBENTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS: AUTOPSIES; ADRENAL
GLANDS; AOETA; BONES; BEAUT;
INTESTINES; KIDNEYS; LUES; LOHSS;
IYBPH »0»ES; FAKCBEAS; SPLEEN;
SIOBACH; THYROID GLANDS; TRACHEA;
ALDRINDB; BAEIDH: CADHXUR; CALCIOB;
CEROBIBB; COBALT; COPPER; IRON; LEAD;
BAGNESIdB; BANGANESE; BETALS;
BOLYBDZNOB: NICKEL; EHOSPHOEHS;
EOTASSIOB; SILICON: SILVER; SODIOH;
STSONTIOB; TIN; TITiNIOB; VANADKffl;
ZINC; BIOACCnaOLATION; BEA1TH
HAZABDS; OCCUPATIONAL HAZARDS;
TOBGDE; ZIBCONIBB; ELEBENTS
Noraal tissue
Autopsies
Japan
JAPAN: ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES: KIDNEYS; LIVEE: LOSGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
ALtJBINDH; BAEIOB; CADHIUfl; CALCIDB ;
CBROBIDB: COBALT; COPPER; IRON; LEAD;
BAGNESIUB; BANGANESE; BETALS;
BOLYBDENUn; NICKEL; EHOSPHCEOS;
POTASSIDB; SILICON: SILVER: SODIDB ;
STRONTIOB; TIB; TITANIOB; VANADIDB;
ZIRC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIECONIUH; EL E BENTS
(NEXI PAGE)
Teraoka, H.
1981
Archives of
Environmental
36(4) :155-165
Teraoka, H.
1981
Archives of
Environmental Health
36 («): 155-165
00
Teraoka, H.
1981
Archives of
Environmental Health
36(«):155-165
-------
Chroniui
7040-47-3
Ct
AtS 51.996, BP 1900 C, BP 2602 C, VP 1
Hq at 1616 C, 10 ma Hg at 1840 C
6257
or ine
(CONTINUED)
HE
EXPOSDRB ROOTE
Inhalation
ANALYTICAI
flETHOD
NOHEEB
OF CASES
a) 13
Vt ^
C) 9
d| 7
e) 14
«) »
91 W
h) 15
i) 83
BABGE
a) 4-tl ug/1
b) 4-5 ug/1
C) 4-60 ug/1
d) 7-110 ug/1
e) 4-40 ug/1
f) 10-15 ug/1
g) 4-130 ug/1
h) 6-190 ug/1
i) 4-190 ug/1
SEAN
a) 4.8 tor- 1
c) 9 *or- 2.6
d) 11 »or- 2.
e) 11 «or- 2.
f) 13 tot- 1.
h) 24 »or- 2.
i) 10 *ot- 2.
Geometric
. 5 ug/1
ug/i
9 ug/1
0 ug/1
2 ug/1
6 ug/1
7 ug/1
GENERAL IBFOBBATION
a) Tungsten inert gas welders. 10%
weldicg, noosaokers
b) sale as a) , saokers
f) Sane as e) , snokers
g) >or= 90* BHA welders, nonsnokers
h) Save as g) , siokers
i) All welders
Correlation between BBA exposure
level and reianent Bagoetic field of
chest area, significantly bigher
stainless steel welders, Finland
FINLAND; URINE; CHROBIDH; BETALS;
NICKEL; FUBES; INDUSTRIAL PLANTS;
1BDOSTBIES; OCC0PATIOSAI HAZARDS;
SPOKING
BEFEEENCE
Kallio»aki, P.-L.
Bahkonen, E.
Taaraneo, V.
Kalliomaki, K.
Aittonieii, K.
1981
of Occupational and
Environaental Health
119:67-75
1
1
1
Cobalt
7«(lO-48-4
Cc
AtH 58.9332, HP 1493 C, BP 3100 C, IF 1 m» Hg at 1910 C
6258
Adrenal
gland
€259
Aorta
EXPOSURE BODTE
ANALYTICAL
HETKOD
NIIKBEB
OF CASES
Sot given
Not given
<0.2 ppm dry wt
<0.2 ppm dcy wt
GEBEEAL IBFOBBATIOS
Noraal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; BEAST;
IBTESTIBES; KIDNEYS: LI7EB; LONGS;
LTBPH BODES; ptNCGEAS; SPltEN;
STOHACH; THYBOID GLANDS; TRACHEA;
ALOHINDB; BABIDB; CADBMB; CALCIUB ;
CHBOBIOB; COBALT; COPPER; IBON; LEAD;
BAGNESIUB; BABSANESE; BETALS;
fCLYBDEBUn; NICKEL: PHOSPBOBOS;
POTASSIOB; SILICON; SILVER; SODIHS;
SIROSTIOH: TIB; TITASIOB; VABADIOB;
ZINC; BIOACCOBULATION; HEAITH
HAZARDS; OCCUPATION»L HAZARDS;
TONGUE; ZIRCONIUH; ELEHENTS
Nornal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADREHAI,
GLANDS; AOBTA; BOSSS; HEABT;
INTESTIKES; KIDBEIS; LIVES; LDBGS;
LYBPB NODES; EA.8CBEHS; SPtSEK;
STOHACH; THYBOID GLANDS; TBACHEA;
ALDHINOB; BABIUB; C1DBIDB; CALCIDH;
CBEOBIUB: COBALT; COPPER; IROH; LEAD;
BAGNESIDB; BANGABESE; BETALS;
BOLYBDEBDB; NICKEL; PHOSPBCBOS;
PCTA5SIUH; SILICOB; SILVER; SODIOB;
siRoNTiun: TIB; TITANIDB; VANADIOB;
ZINC; BIOACCUBOLATION; SEAITH
HAZARDS; OCCUPATION»L HAZARDS;
TCBGUE; ZIRCONIUB; ELEBENTS
Teraoka, H.
1981
Archives oj
Environnental Health
36(»):155-165
Teraoka, H.
1981
Archives of
Environaental Health
36(4) : 155-165
(NEXT PAGE)
-------
Cobalt
1U40-48-4
Co
At« 58.9332, HP 1493 C. BP 3100 c, VP 1 am Hg at 1910 C
(CONTINUED)
TISSUE
6260
Bone
6261
Hair
6262
Hair
EKPOSUBE BOOTE
-
AHAITTICAL
HETHOD
ES
NA
NA
HOMEER
Of CASES
5
59
BASSE
Not given
135-210 ng/g
a) 0.02-0.95 ppm
b) 0.01-0.4 ppm
c) 0.08-0.5 pp»
d) 0.04-0.95 ppm
HE AN
<2.0 ppm dry wt
Hot given
a) 0. 15-0.07 ppm
b) 0.1*4 tor- 0.09 ppm
c) 0. 19 »or- 0.13 ppm
d) 0. 18 +or- 0.25 ppm
(REXT PAGE)
GENERAL IRFORBATION
Normal tissue
Autopsies
Japan
JAPAN; ADULTS: AUTOPSIES; ADBEHA1
GUNDS; IOBTA: BOIES; HEIST;
ISTESTIHES; ItlDHETS; 1ITIB; IDUSS:
LIBPH NODES; PiHCEElS; SPLEEN;
STOniCH; TBTEOIO GLASOS; TBICBEJ;
AiOBimin; BAFina; CIDBIDB; CALCIOH:
CEFOHIOH; COBALT; COPPEB; IBOH; LEAD;
HAGNESIOH; BABGASESE; BETALS;
BOLTBOISnil; KCICEL: tHOSIHCSOS;
EOTASSIDB; SIHCOHJ SILTBE; SODIOII;
SIBOHTini: TIK; TITAHIOn;
ZIHC; BIOACCOBOLITIOH; HEAITB
BAZABDS; OCCOPATIOH*L HAZABDS;
TCHGD1; ZIBCOSIOB; ELEBESTS
Range of leans, estimated froM graph
Aswan, El Kbacga, Assait, Cairo, and
Alexandria. Eqypt
EGYPT; HAIB; RAILS; AHTIBOHI;
CADBIOB; CESIOB; CHEOBlnB; COBALT;
IROR; RARGARESE; BETALS; BOLTBDEHOB;
SCARDIDH; SELERIDB; SILTEB; TORGSTER;
ZIHC: DBIRKIRG SATEB; POPOLATI01
EIPOSOBE; SOILS; URB.1R AREAS
a) 12 c« length, 105 samples
b) Boot section, 16 saaples
c) Distal section, 18 saiples
d) Students in a), 32 samples
Metropolitan Bombay, India
IRDIA; ADOLESCERTS; ADULTS; HAIB;
ARTIRORT; ABSESIC; BBOBIRE: CADBIUB;
CBLOBISE: CBROBI08; COBALT; COPPEB;
GOLD; IODIRE; I80S; LARTHASOB;
BAMGAHESE; POTASSIOB; SCAHDIDB;
SELESIOB; SILVER; SODIOB; ZIRC; AIB
FOILOTIOR; BIOACCOBOLATIOB; FOSSIL
fOILED PORER PLARTS; IRDOSTBIiL
ABEAS; UDDSTSIAL ATBOSPBEBES;
IRDDSTHIAL EBISSIOBS; IRDHSTRIAL
POLLUTIOR; POPOLATIOS EXPOSURE; DEBAR
ABZ1S; IRDOSTBIAL CHEBICALS
Teraoka. H.
1981
Archives of
Environmental Health
36(4): 155-165
Kasperek, K.
lyengar, G.v.
Feinendegen, L.E.
Bashish, s.
nahfouz, B.
1982
Science of the Total
Environment 22:149-168
00
O
Bhat. K.B.
Arunachalam, J.
Teqnasubramanian, S.
Gangadharan, S.
1982
Science of tie Total
Environment 22:169-178
-------
ccbalt
7HUO-08-II
Co
st» 58.9332, HP 1193 C. BP 3100 C, VP 1 m« Kg at 1910 C
(COHTISOED)
TISEOE
6263
Heart
62 6«
Intestine
6265
Kidney
EXPOSURE ROUTE
_
ANALYTICAL
nETHOO
ES
ES
ES
HUP GEE
OF CISES
a) 6
b) 2
f\ -3
CJ J
d) 1
e) 1
10
a) 8
b) 2
c) 3
d) 1
e) 1
RANGE
a) Hot given
b) <0.2-<0.2 ppm
d) Hot applicable
e) Not applicable
Dry wt
Not given
a) Not given
b) <0.2-<0.2 ppm
c) <0.2-0.60 ppm
d) Not applicable
e) Hot applicable
Dry vt
MEAN
a) 0.22 +oc- 0,06 ppa
b) <0.2 ppn
d) 0.28 ppn
e) <0.2 ppo
Dry wt
<0.2 ppa dry wt
a) <0.2 ppn
ft) <0.2 ppB
c) Not given
d} 0. 35 ppffl
e) <0.2 ppm
3ry wt
GEHEBAL IHPOBHATICH
_
a) Mortal healthy «en
b) ChroKiuii plating workers
d) Airplane painter
«) Stone lason
Rutopsies
Japan
JRFHH; iDOlTS; AUTOPSIES; ADR EN; I.
CLAUDS; AORTA; 00MES; BEAUT;
IHTESTr»ES; KlDXErS; LITEB; LOKGS;
ITPPH HODES; PAHCEEAS; SP1IER;
STOdiCH; THX&OID GLANDS; TB&CHEA;
lIUniHtll!; BABIOW; CADHIDR; C&LCIDfl;
CBBOBlOH; COBALT; COPPER; IRON; LEAD;
HA6HESIDH; HAMGAHESE; 8ETAL5;
MOLYBDENUM; NICKEL; PHOSPHORUS;
PCTASSIOH; SILICOH; SILVER ; SOD TOM ;
SIBOHTIOfl; TIH; TITASIO!!; TAHADIOH;
ZIMC; BIOACCDB01ATJO»; HEALTH
HAZARDS; OCCUPATIONAL RAZABDS;
TOHG0B; ZIBCOHICTH; EtEHEIlTS
Nornal tissae
Autopsies
Japan
0»PH; ADDLIS; JOTOPSIES; IDSEIT1L
GLANDS; AOETA; COVES: BEAR1;
INTESTINES; KIDNEtS; LITER; IOBSS;
ITTPH NODES; CANCBEIS; SPLEEN;
STOBACH; TBISOIP GL1TOS; TBJCHZJ:
Aionmnn; BARIDB; CADBIDH; ctLCion;
CBROnlOH; COBALT: COPPEB; IHON; LEAD;
DAGNESIDII; SANG4BESE: BETALS;
BOLTBDENOB; NICKEL; EHOSPHCBOS;
FOTASSIBII; SILICON: SILTEB; SODIDB;
SIBOBTIOB; TIH; TITiHIOB; TANADIOH;
ZINC; BIOACCOBOLATIOH; »EALTB
HAZARDS; OCCDPATIONAL HAZARDS;
TONGDE; ZIBCOKIOfl; E1EBEHTS
a) Nonal healthy «en
b) Chcoaiav plating workers
c) Cbronte refioiag workers
d) Aicplane painter
e) stone >ason
Autopsies
Japan
JAPAN; ADDLTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; BBAR1;
INTESTINES; KIDHBTS; LITER; LONGS,-
IIHPB NODES: PANCBEAS; SPLEEN;
STOHACH; TUIROIO GLAIDS; T1ACHEA;
ALCBINDB; B1BIOH: CADBIDB; CALCIDB;
CBROBIOB: COBALT; COPPER; IBON; LEAD;
nissEsion; BAHSARESE; BETALS;
rOLTBDENTIB; NICKEL; EHOSPHCBOS;
EOTAssion: SILICON; SILTEB; SODIHB;
STRONTlnB; TIH; TITAKOB-, TAHADIOH;
ZINC; BIOACCDBDLATICB; HEALTH
BAZABDS; OCCUPATIONAL BAZABDS;
TONGUE; ZIBCOMIOB; EtEBEBTS
BEfEHEHCE
Teraokar H.
1931
Environaental Health
36(14): 155-165
Teraoka, H.
1981
Archives of
EnvironseDtal Health
36(1): 155-165
Teraoka, H.
1981
AEcbiTes of
36(1) : 155-165
(NEXT PAGE)
oo
-------
Ccbalt
7440-48-4
Co
AtH 58.9332, BP U93 C, BP 3100 C, VP 1 u> Hg at 1910 C
(CONTINUED)
TISSUE
6266
Liver
6267
Liver
6268
Lung
EXPOSURE ROUTE
ftHALXTICftL
HETHOD
ES
NA
ES
NUMBEB
OF CASES
a) 9
b) 2
C) 3
3) 1
e) 1
30
a) 12
b) 2
c) 3
e) 1
BABGE
a) Hot given
b) 0.22-0.33 ppn
c) 3.31-0.39 ppm
d) Not applicable
e) Not applicable
Dry wt
0.017-0. 16 ug/g
Wet wt
a) Not given
b) <0.2-<0.2 ppm
c) <0.2-<0.2 ppm
e) Not applicable
Dry wt
MEAN
a) 0.31 +or- 0.10 ppm
b) 0.28 ppa
c) 0.34 ppm
d) 0.46 ppB
e) <0.2 ppm
Dry wt
Mot given
a) <0.2 ppm
b) <0.2 ppm
c) <0.2 ppm
e) <0.2 ppm
Dry wt
GENEEAL INFOBBATION
..__
a) Normal healthy men
b) Chromium plating workers
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS: AUTOPSIES; ADBENAL
GLANDS; AOBIA: BONES; HEABT;
INTESTINES; KIDNEYS : LIYEB; LONGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACH; TB«OIB GI.AHBS; TEACHEA;
ilUBISOB; B1RIDB; ODBIDB; CALCIUB;
CBEOBIDB; COBALT: COPPEB; IHON; IBID;
BAGNESIDH; BANGANESE; BETALS;
BOLTBDENUB; BICKIL; PHOSPHOBDS;
EOTASSIDB; SILICON: SILVEB; SODIDB:
STBONTIUB; TIN; TITSNIUB; fANADIUB;
ZINC; BIOACCDBOLATION; HEAtTB
B1ZABDS; OCCUPATIONAL HAZABDS;
TONGUE: ZIBCONIOB; ELEBENTS
Category 1 (first priority element)
as proposed by International Workshop
on Monitoring Environmental Baterials
and Specimen Banking
Autopsies, Baltimore, BD,
ninneapolis. BN, and Seattle, «A
BAKTLAND; BINNESOTA; «ASHINGTON;
ADTOPSIES; LtVEB: BEASDBEBENT
METHODS; ALQHIHUB; ANTIBONY; ARSENIC;
IJBIDB; CADS1BH; CHROBIHB; COBALT;
COPPEB: FLDOEINE; IRON; LEAD;
HANG AXES E; BEBCDBI; BOLYBDENUB;
NICKEL; BOBIDIUB; SELENIU1; SILVEB:
S1BONTIUB; TBALLIDB; TIN; TiNADIUB;
ZINC: POPULATION EXPOSUBE
a) Normal healthy men
b) Chromium plating workers
c) Chromate refining workers
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; ADTOPSIES; ADBENAL
GLANDS; AORTA; BONES; BEABT;
INTESTINES; KIDNEYS; LI7EB; LUNGS;
LIBPH NODES; PANCBEiS: SPLEEN;
STOHACH; TBIBOID GLANDS; TBACHEA;
ALOBIIDB; BABIOB; C1DBIUB; CALCIOfl;
CBSOBIDH; CCBALT: COPPEB; IBOH; 1E10;
HIGNESIDB; BiNGANESE; BETALS;
BOLYBDENUB; NICKEL; PHOSPHOBDS;
POTASSIOB; SILICOB: SILTEB; SODIOB;
SIBONTIOB; HH; IITiwiDB; ViBADIOB;
ZINC; BI01CCDHULATION; HEAITB
HAZARDS; OCCUPATIONAL HAZABDS;
TONGUE; ZIECONIOB; ELE BESTS
BEFEBEHCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4) :155-I65
Harrison, s.H.
Zeisler, B.
Hise, S.A.
1981
EPA 600/S1-81-025, 6
pp.
Teraoka, H.
1981
Archives of
36(4) : 155-165
oo
rO
(NEXT PAGE)
-------
Cobalt
7UOO-U8-4
Co
lt« S8.9332, HP 1U93 C, BP 3100 c, VP 1 an Hq at 1910 C
(CONTINUED)
TISSUE
6269
Ly aph
6270
Nail
6271
'
EXPOSURE ROUTE
ANALYTICAL
METHOD
SS
NA
ES
N OH BEH
OF CASES
a) 3
b) 1
C) 3
d) 1
e) 1
62
5
HANGS
a) Sot given
b) Not applicable
c) <0.6-1. 1 ppm
d) Hot applicable
e) Hot applicable
Dry wt
85-600 ag/g
Hot given
(NEXT
MEAN
a) <0.4 ppm
b) <0.6 ppm
c) Not given
d) 0.76 ppm
e) <0.6 ppm
Dry wt
Not given
.
<0.2 ppm dry wt
PAGE)
GENERAL IB FOE f! ATI OH
-
a) Noraal healthy Ben
b) Chroaiua plating workers
c) Chroaate refining workers
d) Airplane painter
e) Stone nason
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADRENAL
G1AHDS; AOBTA; BONES; BEAFT;
INTESTINES; KIDHETS; LIVER; LONGS;
IYBPH NODES; FANCBEAS; SPLEEN;
STOnACH; THTBOID GLANDS; TBACHEA;
ALOMIMUR; BAHIOH; CADHIUH; CALCIUM;
CHEOniUH; COBALT; COPPER; IRON; LEAD;
RAGNESIUN; HANGANESE; RETALS;
BCLYBDEMaH; KICKEL; PHOSPHCRtfS;
PCTASSIUH; SILICON; SILVEH ; SODIUM ;
S1BOSTIUH; TIN; TITAHIOH; VANADIUM;
ZINC; BIOACCOBULATIOS; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIBCONIUH; ELEMENTS
Range of aeans, estimated from graph
Aswan, El Kharga, issuit, Cairo, and
Alexandria/ Egypt
EGtPt; HAIB; HAILS; AHTIflOST;
CADHIUB; CESIUM; CHBOHIOH; COBALT;
IBON; MANGANESE; METALS; MOLYBDENUM;
SCANDIUM; SELENIUM; SILVEB; TUNGSTEN;
ZINC; DRINKING HATER; POPULATIOH
EXPOSURE; SOILS; URBAN AREAS
Normal tissue
Autopsies
JAPAS; ADULTS; AUTOPSIES; ADBENAL
GIANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
IYMPH NODES; PANCBEAS; SPLEEN;
STOHACH; THYROID GLANDS; TFICHEJ;
ALOMIHUH; BARIUM; CADHIUM; CALCIUM;
CHROMIUM; COBALT; COPPER; IRON; LEAD;
MAGNESIUM; HAHGAHESE; HETALS;
BCLYBDENOM; NICKEL; PHOSPHORUS;
POTASSIUM; SILICOH; SILVER; SODIUM;
S1ROHTIUH; TIN; TITAHIUB; VAHADIUH;
ZINC; BIOACCUHUL1TION; HEALTH
HAZARDS; OCCUPATIOHAL HAZARDS;
TONGUE; ZIHCONIDB; ELEMENTS
REFEREHCE
Teraoka, R.
1981
Archives of
Enviroaaental Health
36 (UJ: 155-165
Kasperek, K.
lyengar, G. v.
Feinendegen, I.E.
Hashish, S.
flahfouz, M.
1982
Science of the Total
Environment 22:149-168
Teraoka, H.
1981
Archives of
36(4) :155-165
00
-------
Cobalt
HI10-H8-H
Co
AtS 58.9332, HP 1193 C, BP 3100 c, VP 1 mm Hg at 1910 C
(CONTINUED)
TISSUE
6272
Spleen
6273
Stoaach
6274
Thyroid
gland
EXPOSURE ROUTE
ANALYTICAL
1ETHOD
ES
ES
ES
NUBBER
OF CASES
a) 9
W 2
C) 3
d) 1
e) 1
10
4
RANGE
a) Hot given
b) <0.2-<0.2 ppm
c) <0.2-0.41 ppm
d) Not applicable
e) Hot applicable
Dry vt
Not given
Not given
BEAN
a) <0.2 ppm
b) <0.2 ppm
c) Not given
d) 0.45 ppm
e) <0.2 ppa
Dry wt
<0.2 ppm dry wt
<0.2 ppm dry wt
GENERAL IHFORBATION
a) Normal healthy men
b) ChroaiillB plating workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEABT;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LYflPH NODES; PANCREAS; SPLEEN;
STOHACH; THY80ID GLANDS; TRACHEA;
H.UBI8UK; BIBIOB; CUSBIOB; ClLCInH;
CBBOBinB; COBALT! COPPEB; IRON; LEAD;
MAGNESIUn; DANGANESE; METALS;
ROLYBDENUB; NICKEL; PHOSPHORUS;
FOTASSIUI1; SILICON; SILVER; SODIDB;
SIRONTIDB; TIN; TITANIOH; VANADIUB;
ZINC; BIOACCUBDIATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUB; ELEBENTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BEART;
INTESTINES: KIDNEYS; LIVER; LBHGS;
LYBPH NODES: PANCREAS; SPLEEN;
STOBACH; THIBOID GLANDS; TEACHEA;
ALOBINUB; BA8IUB; CADBIUB; CALCIUB;
CHROBIUB: COBALT; COPPER; IBO»; LEAD;
BAGIESIUB; HAHGANESE; HETALS;
BOLYBDENUB: NICKEL; PHOSPHORUS;
POTASSIOB: SILICON; SILVER; SODIUB;
SIRONTIDB; TIN; TITANIUB; ViBADIOH;
ZINC; BIOACCOIIULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUB; ZLEBENTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BOIES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBACB; THYEOID GLANDS; TRACHEA;
AIOBINUH; BARIUB; CADHIUB; CiLCIDB;
CGROniUH; COBALT; COPPER: IRON; LEAD;
lUGRESIUft; SAHG1NESE; HETJIS;
BCLYBDENUB; NICKEL; PHOSPHORUS;
POTASSIUH; SILICON; SILVER; SODIOH-,
STEONTIUB; TIN; TITANIUB; VANADIUB:
ZINC: BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOBGUE: ZIRCONIUB; ELEBESTS
REFERENCE
Teraoka, H.
1981
Archives of
36(«) : 155-165
Teraoka , H.
1981
Archives of
Environmental Health
36{»):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(11): 155-1 65
_______^^__ ^_________
PAGE)
00
-------
Cobalt
THHO-HS-II
Co
AtB 58.9332. BP 1H93 C, BP 3100 C, VP 1 >n Hg at 1910 C
(CONTINUED)
ISSUE
75
ngue
76
achea
77
ine
EXPOSURE ROUTE
_
ANALYTICAL
BETHOD
ES
ES
AAS
NDBBER
OF CASES
2
2
BANGE
Not given
.. .
Sot given
0.1-0.75 ug/1
BEAN
<0.2 ppn dry wt
<0. 2 ppm dry wt
0.38 ug/1
GEHEEAL INFORMATION
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOETA; BONES; HEIRI;
INIESTINES; KIDNEIS; LIVER; LONGS;
IIBPH NODES; PAHCBEAS; SPLEEN;
STOHACH; THYROID GLANDS; TRACHEA;
ALCniNDK; BAEIOB; CADBION; CALCIDH;
CBROBinS; COBALT: COPPEH; IRON: LEAD:
9AGNESIOH: HANGANESE; HETALS:
BOIIBDENOH; BICKE1; FHOSPHOBHS;
POTASSIOH: SILICON; SILTEB; SODIOB;
SIBONTIUB; TIN; TITANIOBj VANADIOH;
ZINC; BIOACCUBOLATION; HEAITB
BAZACDS; OCCUPATIONAL BAZACDS;
TONGUE; ZIBCONIUB; ELEBEHTS
Norial tissue
Autopsies
Japan
JAPAN; ADULIS; AUTOPSIES; ADRENAL
GIANDS; AORTA; BONES; BEABT;
INTESTINES; KIDNEIS; LIVES; LUNGS;
1IBPH BODES; PANCREAS; SPLEEN;
STOBACB; TBYROID GLANDS; TBACHEA;
ALDBIHUB; BABIUB; CADBIUB; CA1CIUB;
CBBOBIUB; COBALT: COPPER; IBON; LEAD;
BtGNESIDB; MANGANESE; BETA IS;
BOLTBDENDB; NICKEL; PBOSPHOBUS;
PCTASSIUB; SILICON; SILVER; SODIDtl;
SIBONTIUB; TIN; TITASIUB; VADADIDB:
ZINC; BIOACCOBOLJTIOS; HEALTB
BAZABDS; OCCUPATIONAL BAZAEDS;
TOBGUI; 2IRCOSH1B; SLESESTS
Subjects not occupationally exposed,
Gcnany
GEBBANI; URINE; BEASUBEKENT BETHODS;
COBALT; BETALS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Bealth
36(1):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
00
Ul
Schuiacher-Wittkopf, E.
Angerer, J.
1981
International Archives
of Occupational and
Environmental Health
99:77-81
-------
Copper
71110-50-8
Cu
»tw 63.5H6. SP 1083 C, BP 2595 C, VP 1 nm Hg at 1628 C. 10 ID Hg at 1870 C
ISSUE
16
renal
and
79
rta
80
ood.
asma
EXPOSURE ROUTE
ANALYTICAL
HETHOD
ES
ES
its
RUBBER
OF CASES
7
7
26
RANGE
Hot given
Not given
a) Hot given
b) Not given
SEAN
10 *or- 8.2 ppm dcy
wt
6.6 tor- 2.6 ppm dry
wt
a| 20.78 »or- 6.7
umol/1
b) 21.7 *or- 6.9
u'»ol/l
GENERAL I8FOBBATION
Hornal tissue
Autopsies
JAPAN; ADULTS: AUTOPSIES; ADRENAL
GIANDS; AOBTA; BONES; BEAUT;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYMPH NODES; PAHCBEAS; SPLEEN;
STOBACH; THIROID GLANDS; TRACHEA;
ALOSINOH; BASID9; CiDBIOH; CALCIHn;
CBROBIOB; COBALT; COPPEB; I8OH: LEAD;
niGNESIDn; 9ANGANESE: HETA1S;
HOLIBDENOn; NICKI1; EH05PHOROS;
fCTASSIOB; SILICON; SILVER; SODIOB ;
SIRONTIOB; TIN; TITANIOB; VANADIDB;
ZINC; BIOACCOBOLiHON; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGOE; ZIBCOBIOH; ELEBESTS
Nooal tissue
Autopsies
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LIBPR NODES; PANCREAS; SPLEEN;
SIOBACH; THISOID GLANDS; TBJCHU;
ALDBINDB; BABIOB; CACHIOB; CALCIOfl;
CBEOHIOB; COBALT: COPPEB; IBON; LEAD;
BiGNESION; BANGANESE; BETA IS;
BOLTBDENOH; NICKEL; PHOSPHCEOS;
FOTASSIOn; SILICON; SILVER; SODIOB;
STBONTIOB; TIN; TITABIOB; VANADIOB;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGOE; ZIBCONIUB; ELEMENTS
a) 19 healthy controls
b) 7 patients with acute nyocardial
infarction
BLCOD PLASBA; CARDIOVASCULAR
[ISEASES; HEART DISEASES; COPPEB;
BAGHESIOH; BANGANESE; ZINC
REFERENCE
Teraoka, H.
1981
Archives of
36(1) : 155-165
Teraoka, H.
1981
Archives of
36(»): 155-165
Zuiklev, H.
Bertraa, B. P.
Tetter, H.
Tank, B.
Wirth, «.
1980
Trace substances in
Environmental Health
TIT, D.D. Heiphill, ed.
pp 211-216
(NEXT PAGE)
oo
-------
Copper
71140-50-8
Cu
At« 63.546, HP 1083 C, BP 2595 c, VP 1 in Hg at 1628 C, 10 m Hq at 1870 C
6281
Blooil,
serum
(COHTISOED)
6282
Blood,
vhole
K283
Bone
EXPOSURE FOOTS
ANALYTICAL
METHOD
A»S
X-ray
Spectrometry
ES
HDHBEB
OF CASES
171
27
5
RANGE
a) Hot given
c) Hot given
d) Hot given
e) Not given
g) Not given
h) Hot given
i) Hot given
j) Hot given
k) Hot given
Not given
Hot given
MEAH
a) 1. 5 +or- 0.13 ppa
c) 1.8 +or- 1.5 ppm
d) 1.« +or- 0.51
ug/nil
tig/ml
£) 2. 6 +or- 1 . 4 ug/ml
g) l.tt +or- 0.32 ppm
h) 1. 9 +oc- 0. 10 ppm
j.) 1.3 + or- 0.27 ppa
k) 1.4 +or- 0.2 ppm
1) 1.3 +or- 0.3 ppm
1.2 ppn
t.6 tor- 1.1 ppm dry
«t
GENEBAL INFORMATION
a) R spiratory tract, 26 cases
c) B ast, 52 cases
d) B ast, stage I and II, 19 cases
e) B ast, stage III, 6 cases
g) C vix, 11 cases
h) Le kesia, 10 cases
i) Melanoma , 21 cases
j) Hodgkin's lynfhoia, 10 cases
k) Healthy volunteers, 10 cases
a)~1) type of cancer
c) , h) , and j) significantly higher
than k) and 1)
e) and f) significantly higher than
level varied with stage of breast
cancer, highest in advanced stages
level increased over 5 no in
radiotherapy patients with poorest
prognosis
Cancer patients (15-81 yr olds).
geriatric patients (65-81 yr olds).
healthy volunteers (20-41 yr olds) ,
OK
UNITED KINGDOM; CARCINOMAS; LEUKEMIA;
MELANOMAS; NEOPLASMS; SARCOMAS; BLOOD
SEROH; CALCIUM; COPPER; (UGHESION;
MANGANESE; METALS; ZINC;
BICIHDICATORS
Precision 181
FLOOD; HBASOEEMENT METHODS; COPPER;
IRON; METALS; ROBIDiaB; SELENIOH;
ZINC
Noraal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; ICIDSEYS; LIVEE ; LUNGS;
tYfPB NODES; PASCEEAS; SPLEEN;
ST01UCB; THYEOID GLANDS; TBACHEA;
ALCBINUK; BARIUB; CADBIOB; CALCIDK;
CBEOBIOB; COBALT; COPPER; IBON; LEAD;
BAGNESIDB; BANGANESE; BETALS;
BOLTBDEHOB; NICKEL; PHOSPHORUS;
EOTASSItJB; SILICON; SILVEE ; SODIDB;
STROHTIOB: TIN; TITANIOH; SANADIUS;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONItJB; ELE9ENTS
EEFEEBNCE
Capel, I.D.
Williaas, D.C.
Hanhai, I.K.F.
1982
Bearse, B.C.
Close, D.A.
Balanify, J.J.
o«barqer, c.J.
1974
Analytical Chesistry
46{4):499-503
Teraoka, R.
1981
Archives of
Environmental Health
36(4): 155-165
00
(BEXI P4GE)
-------
Copper
7440-50-8
Cu
Jt» 63.546, BP 1063 C, BP 2595 C, vp 1 >m Hg at 1628 c, 10 •> Hq at 1870 C
(CONTINUED)
TISSUE
6284
Bone
6285
Hair
6286
6287
Hair
EXPOSURE ROOTS
ANALYTICAL
METHOD
NA
HA
NA
AAS
HUBBER
OF CASES
a) 7
b) 5
56
2
RANGE
a) 2-8 ppm
b) 2-4 ppm
3.2X10(E-6)-3237X10 (E-6)
g/cu Cm
a) 7-53 pp»
c) 8-75 pp»
d) 7-52 ppm
a) Not given
b) Not given
c) Not given
d) Not given
. -
BEAN
a) 3 pprc
D) 3 ppm
e lans
22. 19X10 (E-6) g/cu cm
a) 21 +or- 9.7 ppm
c) 22.7 +or- 9.3 ppm
d) 22 +or- 11 ppm
a) 40.6 ug/g
b) 40.3 ug/g
c) 12.8 ug/g
d) 10.4 ug/g
GENERAL IXFORBATION
a) Exposed group
b) Controls
45-75 yr old factory workers, Sweden.
ANTHONY; ARSENIC: CADBIUB; COPPER;
HAD; BEBCURI; SELENIOB; SHYER; TIN;
ZINC; BIOACCUBOLiTION; INDUSTRIAL
ATBOSPHERES; INDOSTRIAL PLANTS;
POPULATION EXPOSORE; SBELTEHS; EONES;
FEBDR; COBFARATIVE EVALUATIONS;
SUEDES; AOTOPSIES; OCCOPATIONAL
RA2&SDS; KETALS
3 CK segments of single hairs
Scae samples below detection liKits
IRIDIOB; HAIR; FORENSIC BEDICINB;
BBASUBEBENI BCTHODS; ANTIBONt;
ARSENIC; BSOBIDE; COPPER; COLD;
LANTHANOH; HANGANESE; BERCORT;
BETALS; SELENIOB; SILVER; SODIOB;
STBONTXOn; ZINC; INDOSTFU1
ATBOSPBERES
A) 12 cm length, 101 sanples
c) Distal section* 18 samples
d) Students in a) , 22 samples
Metropolitan Boibay, India
INDIA; ADOLESCENTS; ADULTS; HAIR;
ISTISONY; IE3ESIC; BROBIHE; CIDHIOn;
ceiOBiNE: CBBonioa; COBALT; COPPER;
GOLD; IODINE; IROK; LANTHANDH;
BAHGANESE; POTASSIOB; SC1HDIOB;
SELKNIUH; SILVER; SODIDB; ZINC; AIR
EOLLUTION; EIOACCDBOLATIOI; FOSSIL
FUELED POKER PUNTS; INDUSTRIAL
ABE&S; INDUSTRIAL ATBOSPHEEES;
INDUSTRIAL EBISSIONS; INDUSTRIAL
POLLUTION; POPULATION EXPOSORE; URBAN
AREAS; INDOSTRIAL CHEBICALS
a) Subject 2. unwashed hair
b) Subject 2, after 12 successive
acetone washes
acetone
c) Subject 3, unwashed hair
d) Subject 3, after 12 successive
washes in sodini lauryl sulfate
subjects. Data also for other
procedures and washing agents*
B1IK; COBPAEJTIVE EVALUATIONS;
CADBIUB; COPPER; IRON; BANGAMBSE;
ZINC;
REFERENCE
Liodh, 0.
Brune, D.
Hester, P.-O.
1980
Science of the Total
D;bc2ynski, R.
Boboli, K.
1976
Journal of
Hadioanalytical
Che»istry 31:267-289
Bhat, K.8.
Tegnasubra»anian , S.
Gangadharan, S.
1982
Science of the Total
Environment 22:169-178
Saliela, S.
vuori, E.
Kilpio, J.O.
1981
Analytics Chinica Acta
125: 131-137
00
00
(NEXT PAGE)
-------
Ccpper
7UHO-50-8
Cu
Stw 63.516, BP 1083 C, SP 2595 C, VP 1 mm Hg at 1628 c, 10 mm Hg at 1870 C
(CONTINUED)
TISSDE
6288
Heart
6289
Intestine
6290
Kidney
EXPOSURE ROUTE
ANALYTICAL
BETHOD
ES
ES
ES
NUHBER
OF CASES
a) 8
b) 2
c) 3
e) 1
10
a| 8
b) 2
c) 3
d) 1
e) 1
BAHGE
a) Not given
b) 5.0-13 ppm
C) 7.1-10 ppffl
e) Hot applicable
Dry wt
Hot given
a) Not given
b) 6.0*11 ppm
c) 6.0-21 ppo
d) Hot applicable
e) Hot applicable
Dry wt
BEA.N
d) 8.8 +or- 2.8 ppa
b) 9 ppm
c) 8.8 ppn
e) 4.5 ppm
Dry wt
6.0 +or- 2. 1 ppm dry
wt
a) 12 tor- 5.9 ppm
b) 8.5 ppm
c) 15.3 ppm
d) 8.2 ppm
e) 5.8 ppm
Dry «t
1
GEHEBU. IHFOEHATIOH
a) Normal healthy men
b) Chromium plating workers
c) Chromium refining iforkers
e) Stone mason
Autopsies
Japan
JAEAH; ADULTS; AUTOPSIES; ADCENAL
GUSDS; AOBTA; BOHES; HEART;
IHTESTIHES; KIDHEYS; LITER; LOUGS;
LYflPH NODES; PANCBEAS; SPLEEN;
SIOB4CH; TBIROID SLAITDS; TRACHEA;
AIDBINOB; BARIOB; CADBIOB; CALCIOB;
CHROBIDM: CCEALI; COPPER; IRON; LEAD;
BAGNESIOB; BAHGANESE; BETALS;
PCLYBDENOB; HICKBL; EBOSPHCRDS;
POTASSJOB; SILICOS; SILVER; SODIOB;
SIROHTIOB; IIK; TlrASIOB; VANADIDB;
ZISC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZAEDS;
TOHGOE; ZIRCONIOB; ELEBEHTS
Normal tissue
Autopsies
Japan
JAPAH; ADULTS; AOTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES: KIDHEYS; LIVER; LOHGS;
1YBPH HODIS; EAHCBEAS: SPLEBNj
STOBACB; THYROID GLAHDS; TRACHEA;
ALOBINUB; BARIDB; CADBIOB; CALCIUH;
CBROHIDS; COBALT; COPPER; IROS; LEAD;
HAGNESIDB; BANGANESE; BETALS;
BOLYBDEHtJH; NICKEL; PHOSPHORUS;
PCTASSIOB; SILICON: SILVER; SODIDB;
STEONTICB; TIH; TITAHIOH; VAHADIOfi;
ZINC; EIOACCUHOLATIOH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCOHIDB; ELEHENTS
a) Normal healthy men
b) Chromium plating norkers
c) Chromium refining workers
d) Airplane painter
e) Stone mason
Autopsies
JAPAH; ADULTS; AOTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES: KIDNEYS; LIVER; LUHGS;
IYBPH NODES; PANCCEAS; SPLEEN;
STOBACH: THYROID GLANDS; TRACHEA;
ALOBINUB; BARIUB; CADBIUB; CALCIDB ;
CHROBIOB; COBALT; COPPER; ISDN; LEAD;
BAGNESIUB; KANGANESE; BETALS;
BOLYBDEHUB; NICKEL; PHOSPHORUS;
POTASSIDS; SILICON: SILVER; SODIDB;
STROHTIOB; TIN; TITASIOB; VANADIDfl;
ZINC; BIOACCDBOLATIOH; HEALTH
HAZARDS; OCCUPATIOHAL HAZARDS;
TCNGtJE; ZIRCONIDB; ELBBENTS
REFERENCE
Teraoka , H.
1981
Archives of
36(«) 1155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4) M55-165
Teraoka, H.
1981
Archives of
Environmental Health
36(«): 155-165
(HEIT PAGE)
oo
-------
Copper
7440-50-8
Cu
At» 53.546, HP 1083 C, BP 2595 C, V? 1 ma Kg at 1628 c, 10 in Kg at 1870 C
(CONTINUED)
TISSUE
6291
Liver
6292
liver
6293
lung
1
EXPOSURE ROUTE
ANALYTICAL
METHOD
ES
AS 7
LSV
NA
IS
HUBBEB
OF CASES
a) 9
t>) 2
c) 3
d) 1
e) 1
30
a) 12
M 2
e\ 3
4) 1
e) 1
BADGE
a) Not given
b) 13-19 ppm
c) 14-21 pp»
d) Not applicable
e) Hot applicable
Dry wt
.
3.2-14.7 ug/g
8et lit
a) Not given
b) 8.0-10 ppn
c) 8.3-13 ppn
4) Sot applicable
e) Not applicable
Dry wt
BEAN
a) 18 tor- 7.7 ppa
b} 16 ppn
c) 18 ppm
d) 17 ppm
e) 11 ppm
Dry wt
Not given
a) 9.5 +or- 3.8 ppm
b) 9 ppn
c) 10.2 ppm
d) 7.2 ppm
e) 7.5 ppm
Dry wt
GENEBAL INFORBATION
a) Normal healthy men
b) chromium plating workers
c) chromium refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AOBTA; DOMES; BEABT;
INTESTINES; KIDNEYS; LITER; LONGS;
lifts NODES: PANCREAS; SPLEEN;
STOHACR; THYROID GLANDS; TRACHEA;
AIDBINUB; BARIUB; CADBIOH; CALCIOd;
CFSOBlnn; COEALT; COPPER; IBON: LEAD;
K1GNESIOH; MASGAHESE ; I1ETALS;
BCITBDENOB; NICKEL; PBOSPHOROS;
POTASSIDB; SILICON; SILTEB; SODIOB;
STRONTIDB; TIN; TITANIOB; ViNADIOB;
ZINC; BIOACCaHnLATIOll; BEllTB
BA2ARDS; OCCOPATIOSAL BAZAEDS;
TONGUE; ZIBCONIOB; ELEBENTS
Category 3 as proposed by
International workshop on Monitoring
Environmental Baterials and Specimen
Eanking (trace element of
environmental importance net included
ID first priority list)
Autopsies, Baltimore, BD,
Minneapolis, BN, and Seattle, H>
BABYLAND; BINBESOTA; VASBINGTON:
AUTOPSIES; LITER; BEASUBEBENT
BETHODS; ALOBINOB; 1NTIBONT; ARSENIC;
EAEIOB; CADBIDB; CRROBIUK; COBALT;
COPPEB; PLOORINE; IBON; LEAD;
BANGA«ESE; BERCDRT; BOLTBDENDB;
NICKEL; BDEIDIOB; SELENIQB; SILTEB;
SIRONTIOB; TBALLIOB; TIN; TANADIDB:
ZINC; POPULATION EXPOSURE
a) Normal healthy men
b) Chromium plating workers
c) Chromium refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA: BONES; BEABT;
INTESTINES; SIDNEYS; LITER; LUNGS;
LIfPH NODES; PANCREAS; SPLEEN;
STOHJCH; THIROID GLANDS; TRACBEA:
ALOBIN0B; BARIDB; CADBIUB; CALCIUB;
CBROBIUB; COBALT: COPPEB; IBON; LEAD:
BAGNESIUH; BANGANESE; BETALS;
BOLIBDENUB; NICKEL; PHOSPHORUS;
PCT1SSIOB; SILICON: SILVER; SODIUB ;
SIRONTIUB;. UN; TITAKDB; THADIUB;
ZINC; BIOACCUBUL1TION; HEALTH
HAZARDS; OCCOPATIOHAL HAZARDS;
ICNGOE; ZIBCONIUB; ELEBEHTS
(NEXT PAGE)
Teraoka, H.
1981
Archives of
Environmental
36(4) : 155-165
Harrison, S.H.
Zeisler, E.
wise, S.A.
1981
EPA 600/31-81-025, 6
pp.
Teraoka, H.
1981
Archives of
Environmental
36 (4):155-165
-------
Copper
"7 i) HO-50-8
Cu
Atw 63.546, HP 1083 C, BP 2595 C, VP 1 » Hg at 1628 C, 10 » Hg at 1870 C
(CONTINUED)
TISSUE
6294
lymph
node
6295
Pancreas
6296
spleen
EXPOSURE ROUTE
ANALYTICAL
KETROD
ES
IS
ES
I _
NOBBEH
or CASES
a) 3
b) 1
c| 3
d) 1
e) 1
5
a) 9
b) 2
cl 3
d) 1
e) 1
BADGE;
a) Not given
b) Hot applicable
c) 6.6-9.3 ppn
d> Hot applicable
e) Hot applicable
Dry wt
Not given
a) Hot given
b) 9.0-6.8 ppm
c) 3.8-8.6 ppm
d) Not applicable
e) Hot applicable
Dry wt
MEAN
a) 7.6 +or- 2 .3 ppm
b) 9.0 ppn
c) 7.6 ppm
d) 8.2 ppm
e) 3.3 ppm
Dry wt
5.0 *or- 1.7 ppm dry
wt
a} 6. 1 *or- 1.2 ppm
b) 7.9 ppm
c) 5.5 ppm
d) 15 pp»
e) 1.2 ppn
Dry wt
GEBEFJL IHFORBATIOS
a) Horval healthy Ben
b) Chroffi.ua plating worker
c) chroBiua refining workers
d) Airplane painter
e) stone nason
Autopsies
Japan
JAF&H; ADULTS; AUTOPSIES; ADEEHAL
GIAHDS; AOBIA; BOHES: BEAST;
ISTESTIBES: KIDNEYS; LIVER; LDHGSj
LTBPH SODES; EAHCEEAS; SPLIEB;
SIOBACH; THIBOID GLANDS; TEACBEA;
ALUHIHUH; BAEIUH; CADHIOfl; CALCIUB;
CBEOllIOR; COBALT; CO?P EE; IBOH; LEAD;
EAGHESIDH; nANGANESE; HETALS;
BCLYBDENnn; NICKEL; PHOSPHOBUS;
POHSSIDH-, SILICON; SILTEE; SODIOH;
S1ROHTIOB; TIN; IITAHIOB; VAIIADIIJfl;
ZINC; BIOACCUflULATIOH; HEA1TB
BIZAEDS; OCCUPATIONAL HAZAEOS;
TCNGUE; ZIBCONIDB; ELEBENTS
Norval tissue
Autopsies
Japan
JAP4N; ADULTS; AUTOPSIES; ADEENAL
GLASDS; AORTA; BOHgS; HEART;
IMESTIHES: KIDSETS; LIVES; LUNGS;
LYHPH NODES; PANCBEAS; SPtlBN;
STOHACH; THYEOID GLANDS; TBACHEA;
AIUBISOH; BAEIDB; CADHIUB; CALCIDB;
CBBOBIUB; COBALT; COPPEE; IRON; LEAD;
BAGSESIUH; BANGAHESE: BETAIS;
fOIYBBESUH; SICKEL; PHOSPHCROS;
POTASSIUS; SILICON; SILVER; SODIUB;
STEOMIIOll; TI»; TITA»II)»; VANADIOH;
ZINC; BIOACcnifULATION; BBAITB
HAZARDS; OCCOPATIONAl BAZAEDS;
; zieconian; ELEBEKTS
a) Noraal health; nen
b) Chroniaa plating workers
c) chroniua refining workers
dj Airplane painter
e) Stone lason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BEAR!;
INTESTINES; KIDNETS; LIVER; LUBGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACH; TRYROID GLANDS; T8ACHEA;
1LUBIBUB; BARIDB; CADBIUB; CALCIUB;
CBROBIUB; COBALT; COPPER; IRON; LEAD;
BAGHESIUN; SAHGSSESE; 8BTALS;
BOLYBDENDn; NICKEL; EHOSPHCRUS;
EOTASSIUB; SILICON; SILVER; SODIUB;
SIRONTIUB; TIN; TITANIUB; VANADIUfl;
ZISC; BIOACCOfltrLJTIOB; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TCSSUE: ZIECONIUB; ELEBENTS
(HEX! PAGE)
Teraoka, H.
1981
Archives of
Environaental Health
36(4): 155-165
Teraoka, H.
1981
Archives of
Environmental
36(4): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
-------
Copper
711 CIO-50-8
Cu
AtS 63.5«6, BP 1083 C, BP 2595 C, VP 1
Hg at 1628 C. 10
Kg at 1870 C
(CONTINUED)
6297
Stonach
6298
Thyroid
gland
6299
Tongue
BXPOSORE POOTE
ANALYTICAL
BETHOD
NOHBEB
OF CASES
Not given
Not given
Not given
6.0-+OC- 2.1 ppm dry
wt
3.4 *or-
wt
. 1 ppm dry
7.4 +or- 5.1 ppm dry
GENERAL INFORHATION
Noraal tissue
Autopsies
Japan
JAPAN: ADULTS: AUTOPSIES; ADRENAL
GLANDS; AOBTA: BONES; 8BAHT;
INTESTINES: SIDNEYS; LIVEE; LONGS;
LYBPB NODES; PANCREAS; SPLEEN;
STOBACB; THYROID GLANDS; TBACHEA;
ALOBINUB: BABina; CAOBIOB; CALCIM;
CBBOBIOB; COBALT; COPPER; IBON; LEAD;
aiGNESinn; HANSANESE; METALS;
noLTBDENnn; HICKIL; EHOSPHCBOS;
POTASSIOII; SILICON; SILVER; SODIOB;
SIEONTIOn; TIN; TITAHnB: VlBADIOa;
ZINC; BIOACCOMOLATION; HEALTH
HAZARDS; OCCDPATIONAL HiZABDS;
TOUGUE; ZIBCONIDB; ELEBEHTS
Noraal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AOETA; BONES; BEABT;
IHTESTINES; KIDNEYS; LITER; LONSS;
IYBPH NODES; PAHCBEAS; SPLEEN;
STOBACR; TBYROID GLANDS; TB1CHEA;
ALOBIHDfl; BARIDB; CADBIDB; CALCIDB;
CEBOBIDB; COBALT; CCPPEB; IBON; LEAD;
BAGHESIDB; nABGlllESZ; BETA IS;
BOLYBDENOB: NICltEL; PHOSPHOSOS;
POTASSIDB; SILICOB; SILVER; SODItJB;
STRONTIOB; TIN; TITAKIOB; VINADIUH;
ZISC; BIOACCDBOLSTIOS; HEALTH
BAZARDS; OCCOPlTICKiL HSZABDS;
TONGOE: ZIBCONIUB; ELEBENTS
Nonal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADREHAL
CLAUDS; HOETA; BODES; HEART;
INTESTINES: KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCEEAS; SPLEEN;
S10DACH; THYROID GLANDS; TRACHEA;
ILOHIIOH; BAHIDS; CADBIOB; CALCIDB;
CBROBIOB; COBALT; COPPER; IRON; LEAD;
BAGNESIDB; B1NGAIESE; BETALS;
BOLYBDENDB; NICKEL; PHOSPBOROS;
PCTASSIOH; SILICOS; SILVER; SODIUB;
STRONTIDB; TIN; TITANIOB: VANADIDB;
ZINC; BIOACCOBDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGOE; ZIRCONIOB; ELEBE»TS
Teraokar B.
1981
Archives of
Environmental Health
36(») : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(«):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(1):155-165
(NEIT PAGE)
-------
Ccpper
7190-50-8
Cu
At8 63.516, HP 1083 C, BP 2595 C, VP 1 •» Hg at 1628 C, 10 •• Hg at 1870 C
(COHTINUED)
TISSOE
fSOO
Trachea
EIPOSOBE EOtJIE
ANALYTICAL
BETBOD
ES
HOHBEB
OF C»SES
2
BAHGE
Hot given
MEAN
3.2 K>r- 0.07 ppin dry
wt
—
Ho
Au
Ja
Jt
SI
IV
IT
ST(
AL
CB
BA
B01
PO-
SI
21
HA
TC
GEIEBAL IHFOHI1ATIOH
Horial tissue
Autopsies
JAEAH; ADOLTS; AUTOPSIES; ADRENAL
GIAHDS; AOfiTl; SCUSS; BEAST;
INTESTINES: KIDNEIS; IIVEB; LOHGS;
tlBPfl HODES; PAHCBEAS; SPLEEN;
STOHACH; THTBOIO SLAHDS; TEACHEA;
JLOfllSUfl; BAGIOn; CAODIOn; CAICIOn;
CEEOfllOn; COBALT: COPPEfi; IRON; LEAD;
BAGHESIDH; HAHGAHESE; BETALS;
BOLTBDKHnM; HICItIL: PHOSPHCEOS;
POTASSIOB; SILICON: SIIYEE; soDinn;
STEONTIUB; TIH; TITAIIIDI); TANAOiaD;
2 ISC; BIOACCOHOLATIOH; BEALTH
HAZASDS; OCCUPATIONJl HAZAEDS;
TCSGOB; ZIBCOHIOB; ELEHEHTS
Teraoka, H.
1981
Archives of
EDTirouMental Bealth
36(«):155-165
comarin (8 ci)
2H-1-Benzopyran-2-one (9 CI)
91-611-5
C9-H6-02
n« 106.1, BP 70 C. BP 291.0 C, 7P 1 II Hg at 106.0 C
TISSUE
6301
Breath
EXPOSDBE HOOTE
AHALYTICJ1
BETHOD
sc/ns
HUB BEE
OF CASES
28
B1HSE
0.07-0.63 og/1
0.22 ng/1
GEHEBAL INFOEHITION
Estimated froi graph
Healthy 18-60 yr olds, nonsaokecs.
fiigid protocol 14 days before and
during study to liniaize nuiber and
aiount of exogenous constituents.
ACOLTS; BEEATH; ALCOHOLS; C9LOEIHE
CBGASIC COHPOOHDS: CHLOEOBEHZENES
BEFEEEHCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
claudio, H.P.A.
1977
Journal of
Chronatographic Science
I5:239-2««
U)
Cniene (8 CI)
Eenzene, (1-iethylethyl) - (9 CI)
98-82-8
C9-H12
BW 120.19, IIP -96 C, BP 152 C, VP 10 i« Hg at 38.3 C
TISSOE
6302
BXPOSOEE EOOTE
ANALYTICAL
HETHOD
GC/HS
imnBEE
OF CASES
28
EAHGE
0.08-2 ng/1
BEAM
0.35 ng/1
GESEBAL IHFOSBATIOS
Estimated froi graph
Healthy 18-60 yr olds, nonsiokers.
Eigid protocol 11 days before and
during stud; to ainilize nuiber and
aiount of exogenous constituents.
ACOLTS: BEEATH: ALCOHOLS; CHLOBJBE
ORGANIC COHPOONDS; CHLOEOBENZENES
EEFEEENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, B.P. A.
1977
Journal of
Chroaatographic Science
15:239-2»»
-------
CuriiiB
74(10-51-9
Ct
AtW 2147, HP 1310 * or - 10 C
IISSDB
6303
urine
EXPOSOPE BOUTE
Dermal
ANALYTICAL
HETHOD
NtJHBEB
OF CASES
a) 1
b) 1
c) \
at i
EA8GE
a) 16.3-0.07 dpm/day
b) 81-0. 15 dpa/day
c) 9.06-1.91 dpa/day
fi) 26.2-1.11 dpa/day
HEAN
a) Hot applicable
b) Not applicable
ci Not applicable
d) Not applicable
_
GENERAL INFORHATIOH
a) Day 1 and day 119 after uptake
through puncture voand in finger
t) Day 1 and day 115 after acid burn
c) normalized data for (a)
JtOlIS; CASE HISTORIES: OEIKE;
INDUSTRIAL ACCIDENTS; OCC0IATIOMAL
HAZARDS; EA OIOISOTOPES ; RJCIOHOCLIDES
REFERENCE
Parkinson, B.H.
Henley, L.C.
Nestor, c.».. Jr.
1980
Health Physics
39:977-980
Cyanide
57-12-5
C-H
"» 26.02
SSDE
1
od
EXPOSURE BODTE
Inhalation
ANA1ITICAL
flETHOD
OC
NOHBEB
OF CASES
53
BASSE
_
a) 0.5-13 umol/liter
b) 2.2-13 unol/liter
c| 0.5-3.9 amol/liter
d) 2.0-126 u«ol/liter
HEAN -
a) 5.0 umol/liter
b) 6.6 umol/liter
c) 2. 1 umol/liter
d) 25.8 umol/liter
a
c
t
c
c
a
u
e
c
c
s
c
c
I
GENEEAL IMFORP1JITICH
a) 17 fire survivors, no clinical
evidence of snoke inhalation. Hean
Carboxyheaoglobin, 3.8*
11 saofcers frci a) Hean
carb ozyhe «oglobin, U.7 %
c) 6 non-smokers froa a) . Hean
carboxyheioglobin, 2.\%
d) 36 fire survivors, clinical
evidence of sioke inhalation. Hean
carboxyheaoglobin, 11.5%. Blood
carboxyhenoglobin confirmed severe
sBoke inhalation in absence of
conclusive clinical evidence
SBOKE IHB&LVTI08; SCOTLABD; BLOOD;
CtANIDE; FUSES; HEALTH HAZAHDS:
INHALATION; SHORING
EEFEBENCE
Clark, C.J.
Campbell, D.
Eeid, U.S.
1981
tancet
1 (8231) : 1332-1335
Cyclohexane
110-82-7
C6-H12
US 81.16, IIP 6.5 C, BP 80.7 c, »P 100 BM Hg at 60.8 C
TISSUE
6305
Breath
EXEOSOfiE ROUTE
A NAUTICAL
METHOD
ac/ns
SOU BED
OF CASES
28
BA
2.3-8.5 ng/1
"4.5 ng/1
GENERAL INFORMATION
E£tiiated fron graph
Healthy 18-60 yr olds, nonsiokers.
Rigid protocol 14 days before and
daring stady to linikize nuiber and
aionnt of erogenous constituents.
AIULTS; EEI1TB; ALCOHOLS; CHLORINE
ORGANIC COHPOOHD5: CHLOBOBEHZEHES
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, B. p. A.
1977
Journal of
chromatagraphic Science
15:239-244
-------
Cyclohexane, 1,2,3,4,5,6-hexachloro-, alpha- (8 CI)
Cyclohexane, 1,2,3,»,5,6-hexachloro-, (lalpha,2alpha,3beta,1alpha,5beta.6beta)- (9 CI)
319-84-6
C6-H6-C16
UK 290.63, flP 159.5-160 c, BP 288 C, VP 0.02 im Hg at 20 C
TISSUE
6306
Adipose
6307
Adipose
6308
Blood,
serum
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC
GC
GC
NOflBER
OF CASES
a) 8
b) 3
a) 19
b) 9
C) 9
77
RANGE
a) 1-15 mg/kg
b) 0.01-0.2 mgAg
Extractable lipid basis
a) Not detected-0.08 ug/g
b) Not detected-0.08 ug/g
c) Hot detected
.
a) 1J-273 ug/1
b| 50-183 u0.01 ug/g)
t) Hexico city. Pesticide exposure
itainly from foods shipped in fron
other areas (7 samples >0, 01 ug/g)
c) Puebla. Industrial and traditional
agricultural region with low
pesticide use
Sondetectable le»els=0.005 ug/g
Residents of Mexico
MEXICO; AUTOPSIES; ADIPOSE TISSUE;
SOFGEBT; CHLORINATED HIDBOCABBOMS;
CHIORISE ORSAHIC COBPOONDS; DCD; DDE;
DET; EIELDRIB; HBXACHLOROCYCLOHEXAN E;
IINDA»E; PESTICIDES; PESTICIDE
RESIDUES; POPULATION EXPOSOBE; DRBAN
AREAS
a) 18 working in RCH synthesis
b) 7 vorXing in alpha-HCH extraction
c) 11 working in alpha-HCH
deconposition
d) 21 working in ga>ma-HCH
purification by fractional oethanolic
crystallization
e) 57 total of aj-d)
f) 20 controls
Saaples at end of working week
•g/cu B
Hales (nean age 42 +or- 10 yr)
esployed in lindane production for
1-30 yr (Bean exposure, 10 +or- 9
clerks.
GERHANY; ADOITS; ADIPOSE TISSUE;
BLOOD SERDH; INDUSTRIAL HEDICINB;
CHLORINATED HyDROCA RBONS;
HHfcCHLOBCCtCLOHnAHE; LIHCANE;
PISTICIDES; AIR POLLUTION;
EIOACCOMOLATION; HEALTH HAZARDS;
INDUSTRIAL ATMOSPHERES; INCUSTRUL
PLANTS; INHALATION; OCCUPATIONAL
HAZABDS; PESTICIDE RESIDUES;
INDUSTRIAL CHEMICALS
REFERENCE
fiauBann, R.
Angerer, J.
Heinrich, R.
Lehnert, G.
1980
International Archives
of Occupational and
47:119-127
...._.._
Albert, L.
ftendez, f.
Cebrian, M. B.
Portales, A.
1980
Archives of
STVTironmental Health
35 (5): 262-269
Baumann, K.
Angerer, J.
Heinrich, R.
Lehoert, G,
1980
International Archives
of Occupational and
Environmental Health
«7:119-127
VO
Ln
(KEXI PAGE)
-------
Cyclohexane, 1,2.3,4,5,6-hexachloro-, alpha- (8 CIJ
Cyclohexane, 1,2,3, 1,5,6-hexacbloro-, (lalpha, 2alpha,3beta,4alpha,5beta,6beta) - (9 CI)
319-81-6
C6-H6-C16
BW 290.83, IIP T59.5-160 c, BP 288 C, VP 0.02 mi Hg at 20 C
(CONTINUED)
TISSUE
I
6309
Blood,
serum
BIPOSOBE BOOTE
__ _ _ _ .
ANALYTICAL
HETHOD
SC
NOHBEE
OF CASES
a) 32
b) 27
c) 81
d) 68
BANGS
a) 0.0-0.04 ppm
b) 0.002-0.057 ppm
o) 0.003-0.016 ppm
d) 0.00 1-0.085 ppm
f) 0.021-0.131 ppa
g) 0.01S-0. 160 ppm
J.) 0.031-0.165 pp»
HEAS J GENIBAL INFOEBATICS
a) 0.01 tor- 0.0068
PP«
b) 0.010 tor- 0.0086
ppm
pp.
d) 0.018 tor- 0.0165
e) 0.016 tor- 0.008
f) 0.078 tor- 0.028
g> 0.096 »or- 0.039
ppm
h) 0.063 tor- 0.037
ppm
i) 0.077 tor- 0.02814
ppm
j) 0.051 tor- 0.0327
ppm
a) No previous exposure
b) 1 season of prior exposure
c) 2 seasons of prior exposure
d) 3 seasons of prior expsure
f) Group a) , post-exposure
g) Group b) , post-exposure
i) Group d) , post-exposure
a)-e) Pre-exposure
grade HCH (3.1% alpha, .11 beta, and
It gamma) , applied with pump (20
•g/sg ft)
19-49 yr old malaria spraymen with
0-1 seasons prior occupational
exposure
IDOLTS; BLOOD SEEDB; CHLORINtTED
HYBROCJEBONS; CHLORIHE OHGJKIC
COMPOUNDS; BEIiCKLOKOCTCLOFIIiBE;
PISTICIDBS; OCCDPJ1TIOHM, BJZJBDS;
PISTICIDE RISIDOES
EEFEEESCE
Gupta, S.K.
Parikh, J.S.
Shah, K. P.
Chatterjee, S.K.
1982
irchives of
37(1) :11-«1
Cyclohexane, 1,2,3,1,5,6-hexa
cyclohexane, 1,2,3,1,5,6-hexa
319-85-7
C6-H6-C16
»» 290.83, »P 311-315 C (subl
6310
Adipose
EXPOSURE BOOTE
hloro-, beta- (8 CI)
hloro-, (1alpha,2beta,3alpha,4beta,5alpha,6beta|- (9 CI)
mes), BP 60 C at 0.58 Km Hg, VP 0.005 mm Hg at 20 C
ANALYTICAL
METHOD
GC
NUNBEB
OF CASES
a) 8
b) 3
BANGE
a) 18-103 mg/kg
b) 0.3-2.1 mg/kg
Extractable lipid basis
MEAN
a) 45.6 +oc- 24.4
ag/kg
b) Not given
Extractable lipia
basis
.
GENERAL INFOEBATION
a) Hexachlorocyclohexane workers
b) Controls
Subcutaneous tissue from abdoien
Levels about 300-fold higher than in
serum
Bales employed in lindane production.
GEEBANT; ADULTS; ADIPOSE TISSUE:
BIOOD SEROB; IBDOSTBIil BEtlCIHt;
CELOBINATED fiTDBOClEBO NS ;
BIIACHLOBOCrCLOHEUBE; LIRDANE;
PISTICIDES: AIB POL10TI01I;
EIOACCOBDLATION; HEALTH HS2AEDS;
ISDOSTBI1L ATBOSPHEBES; INDOSTBIll
FLIRTS; INBAtATIOS; OCCOPA1IONAL
BAZABOS; PESTICIDE EESIDOES;
I1DQSTGIAL CHEBICALS
EEFEBENCE
Baumann, K.
Angerer, J.
Beinrich, R.
Lehnert, G.
1980
International Archives
of Occupational and
17:119-127
(BEIT PAGE)
-------
Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta- (8 CI)
Cyclohexane, 1,2, 3.«, 5,6-hexachloro-, (1alpka,2beta,3alpha,«beta,5alplia., 6ieta) - {9 CI|
319-85-7
C6-H6-C16
BS 290.83, BP 311-315 c (sublimes), BP 60 c at 0.58 mi Hg, VP 0.005 •• H0.01 ug/g)
t) nexico City. Pesticide exposure
•ainly fro* foods shipped in froi
ether areas fl samples >0.01 09/9)
c) Peubla. Industrial and
traditional agricultural region with
low pesticide use (2 saaples >0.01
ug/g)
levels based on extractable lipids.
Mondetectable leTels*0»005 ug/g
Residents of Hexico
BMICO; JOIOPSIBS; 1DIPOSE TISSUE;
SUCGEBI; CHLOEINJTEC HTOROCJBBO«S;
CBLOEISE OFGHNIC COHPODHDS: DEC; DDE:
OCT; CIELDBIK; HBUCBLOBOC ICLOBIIiS E;
LIUDJHE; PESTICIDES: PESTICIDE
EESIDOES; POPOL1IIO8 EJPOSOBE; DBB1H
1EIEILS
a) 18 vorkinq in HCH synthesis
b) 7 working in alpha-BCH extraction
c) 11 working in alpha-HCH
decomposition
d) 21 working in gaMna-HCH
purification by fractional Hetbanolic
crystallization
e) 57 total of a)-d)
f) 20 controls
Samples at end of working week
lir level at work places. 0.001-0.38
•g/cu •
Significant increase vith tive cf
employment
Hales (mean age 42 tor- 10 yr)
employed in lindane production for
1-30 yr (mean exposure, 10 tor- 9
yr), and as controls, unexposed
clerks.
GEBHaNT; ADOLTS; ADIPOSE TISSUE;
BLOOD szann; isDnsTpi.L miiciHE;
CBIOHIHATED HIDROCABB01IS:
HEXACHIOBCCTCLOHIXdBE; LIKCANE;
PISTICIDES; AIB VOLLOTIO1;
BIOACCOHnLATIOK; HEALTH HAZABDS:
IBDOSTBIAL ATHOSPHEBES; IKDOSTBIAL
PLAHTS-, IHBALATIOH; CCCO?IiTIO« AL
BAZABES; PESTICIDE BESIDOBS;
ISDDSTBIAL CBEBICALS
(HSXT Pt(,E)
BEFEBESCE
Albert, L.
nendez, F.
Cebrian, 8. E.
portales, A.
1980
Archives of
Environmental Health
35(5):262-269
Baumann, K.
Angerer, J.
Beinrich, B.
Lehnert, G.
1980
International Archives
of Occupational and
Environmental Health
47:119-127
-------
Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta- (8 CI)
Cyclohexine, 1,2,3,4,5,6-heiachloro-, (lalpha,2beta,3alpha,4beta,5alpha.6beta)- (9 CI)
319-65-7
C6-H6-C16
US 290.83, H? 314-315 C (sublimes), BP 60 C at 0.58 ID Hg. VP 0.005 mm Hg at 20 C
(CONTIiTJED)
TISSOB
6313
Biooa,
serum
EXPOSURE ROUTE
ANALYTICAL
HETHOD
GC
BOBBER
OF CASES
a) 32
b) 27
c) 81
d) 68
e) HO
BABGE
a) 0. 0-0. 250 ppu
b) 0.013-0.033 ppm
C) 0.014-0.689 ppm
d) 0.087-0.699 ppn
e) 0. 044-0. 421 ppm
f) 0.065-0.402 ppm
g) 0. 122-0. 4«4 ppn
h) 0.087-0.635 ppm
i) 0. 130-0.673 ppo
j| 0.089-0.445 ppm
.
BEAN
a) 0.058 *or- 0.0544
pp.
b) 0.086 *or- 0.0635
pp»
c) 0.266 K>r- 0.2005
PPn
d) 0.294 tar- 0. 1418
ppu
e) 0. 146 *or- 0.0781
ppm
f) 0.250 *or- 0.0814
ppm
g) 0.315 for- 0.0971
PP«
h) 0.289 »or- 0. 1072
ppi.
i) 0.385 »or- 0. 1324
ppm
j) 0.225 tor- 0.0723
PP"
a) NO previous exposure
t) 1 season of prior exposure
c) 2 seasons of prior exposure
d) 3 seascns of prior expsure
e) >3 seasons of prior exposure
f} Group a) post-exposure
g) Group b) post-exposure
h) Group c) post-exposure
i) Group d) post-exposure
j) Group e) post-exposure
a)-e) Pre-exposure
f)-j) After 16 wk spraying technical
grade HCH (3.1% alpha, .7% beta, and
IK ga««a), applied vith pu>p (20
ig/sg ft)
19-49 yr old aalaria sprafKen with
0-4 seasons prior occupational
exposure
iCOLTS; BLOOD SEEOB: CH10BINATED
HICBOCABBONS; CHLORINE OBGASIC
COPPOOHDS; BEZACBLOBOCICLOBIXAHE;
PISTICIDES; OCCOPATIOHAL RAZABDS;
PISIICIDE EISIDOES
Gupta, S.K.
Parikh, J.B.
Shah, n.P-
Chatterlee, S.K.
Kashyap, S.K.
1982
Archives of
Environmental Health
37(1) :»!-»»
Cyclohexane, 1,2,3,4,5,6-hexachloro-, ganaa- (8 CI)
Cyclohexane, 1,2,3, 4,5,6-heiachloro-, (1alpha,2alpha,31)eta,
-------
Cycloherane, 1,2,3,4,5,6-hexachloro-, qanta- (8 CI)
Cyclohexane, 1, 2, 3, 4,5,6-herachloro-, (1 alpha,2alpha,3beta,Halp4a,5alpua,Sbeta) - (9 CI)
56-89-9
C6-H6-C16
HR 290.85, up gamma-lsoner crystals 112.5 C, BP 323.4 C, 176.2 C at 10 BB Hg. VP 0.14 mm Hg at HO C
(CONTINUED)
TISSUE
6315
Blood
6316
Blood,
fetal
6317
Blood,
serum
EXPOSURE ROUTE
ANALYTICAL
METHOD
SC
GC
GC
SOBBE8
OT CJSES
100
100
77
BADGE
a) 2.4-135.0 ppb
b) Not given
c) Not given
d) Not given
ej Not given
f) Not given
g) Not given
a) 1.2-175.7 ppb
b) Not given
c) Not given
d) Not given
e) Not given
f) Not given
g) Not given
a) 9-56 ug/1
b) 17-67 ug/1
c) 5-17 ug/1
d) 19-188 ug/1
e) 5-188 ug/1
f) Hone detected
BEAN
a) 19.0 o - 12.4 ppb
b) 14.7 o - 19.2 ppb
0} 27.4 o - 28.8 ppb
d) 19. 1 0-11.8 ppb
e) 21.7 0 - 21.5 ppb
f) 18.4 o - 22.9 ppb
g) 12.2 o — 25.2 ppb
a) 11.8 o - 5.3 ppb
b) 10.2 o-16-l ppb
c) 14.9 0-6.3 ppb
d) 12.4 o - 2.0 ppb
e) 11.4 o - 7. 12 ppb
f) 8.8 +or- 9.6 ppb
g) 16.9 +or- 27.7 ppb
a) 20.4 +or- 12.1
ug/1
b) 35.5 *or- 18.0
ug/1
c) 12.3 tor- 3.5 ug/1
d| 64.3 +or- 53.5
ug/1
e) 36.9 +or- 39.9
ug/1
i) None detected
GENERAL INFORSiTION
a) All subjects
b) 60 subjects, ages 18-25 yr
c) «0 subjects, ages 26-3U yr
d) 42 subjects, vegetarians
e) 58 subjects, Don-vegetarians
f) 13 subjects, rural
g) 57 subjects, ucban
Katernal blood, collected 8-12 hr
before parturition
b) and c) , f) and g) significantly
different
Besidents of Lucknow, India
I»DI»: ADULTS; AGE; FETDS; BLOOD:
PLACENTA: CHLORINE OBGAHIC COBPOUHDS;
CCC; ODE; DDT; HEXACHLOBOCTXLOHIXANE;
LINDANE; PESTICIDES; AGRICULTURE;
BIOICCOBOLATIOS; DIETS; PREGNANCY;
RURAL AREAS; URBAN AREAS; PESTICIDE
RESIDUES; POPULATION EXPOSURE
a) All subjects
b) 56 subjects. Bother's age 18-25 yr
c> 34 subjects, mother's age 26- 3H yr
d) 36 subjects, vegetarian Bothers
e) 54 subjects, non-vegetarian
mothers
f) 42 subjects, rural
g) 48 subjects, urban
Cord blood, collected at delivery
b) and c) , f) and g( significantly
different
INDIA: ADULTS; AGE: FETUS; BLOOD;
PLACENTA: CHLORINE ORGANIC COBPOUNDS;
DEI; DDE; DDT: HEXACHLOROCYCLOHBT.ANE:
LIHDANE; PESTICIDES: AGRICULTURE;
BIOACCDHDLATIOH; DIETS; PREGNANCY:
BURAL AREAS; URBAN AREAS; PESTICIDE
RESIDUES; POPULATION EXPOSURE
a) 18 working in BCH synthesis
b) 7 working in alpha-fiCH extraction
c) 11 working in alpha-RCH
decomposition
d) 21 working in gaBaa-HCB
purification by fractional aethanolic
crystallization)
e) 57 total of a)-d)
f) 20 controls
Samples at end of working week
ag/cu B
Hales (Bean age 42 >or- 10 yr)
enployed in lindane production for
clerks.
GIBMABY; ADOLTS; ADIPOSE TISSUE;
BLOOD SERUfl; IHDUSTRIAL BEDICINE;
CHLORINATED HYDSOC1RB08S;
BIXACHLOEOCYCLOHIXANE; LINDANE;
PESTICIDES; AIR POLLUTION;
EIOkCCDTOHTIOS; HEALTH HAZARDS;
INDUSTRIAL ATBOSPBERES; INDUSTRIAL
PLANTS: INBILATICN: OCCUPATIONAL
HAZARDS; PESTICIDE RESIDUES;
INDUSTRIAL CBEBICALS
REFERENCE
Saxena, B.C.
Siddigui, H.K.J.
Bhargava, A.K.
Krishna flurti, C.R.
Kotty, D.
1981
48:12J-13»
Saxena, B.C.
Siddiqui, B.K.J.
Bhargava, A.K.
Krishna Burti, C.R.
Kutty, D.
1981
Archives of Toxicology
48:127-134
Bauaann, K.
Anqecer,
-------
cycloheiane, 1,2,3,4,5,6-hexachloro-, gamma- (8 CI)
Cyclohexane, 1,2 ,3, 4,5 ,6-hexachloro-, (lalpha, 2alp1ia, 3 beta, 4alpha, 5alpha,6beta) - (9 CI)
58-89-9
C6-H6-C16
US 290.85, HP gamma-isomer crystals 112.5 c, BP 323.4 C, 176.2 C at 10 mm Hg, VP 0.14 mm Hg at 40 C
(COSTin (JED)
TISSUE
Blood,
serum
- 6319
Placenta
EXPOSURE BOOTE
iSAtYTICAL
METHOD
GC
NUtlBEB
OF CASES
b) 27
C) 61
d) 68
100
DABGE
b) 0.0-0.051 ppm
o) 0.0-0.036 ppm
d) 0.0-0.057 ppm
f) 0.0-0.112 ppm
g) 0.0-0.099 ppm
h) 0.0-0.065 ppm
i) 0.0-0. 132 ppm
j) 0.0-0.063 ppm
a) 0.7-95.6 ppb
b) Hot given
c) Hot given
d) Hot given
e) Sot given
f) sot given
g) Sot given
BEAN
PP»
b) 0.004 tor- 0.0074
ppm
ppm
d) 0.009 tor- 0.0120
ppm
e) 0.008 tor- 0.0099
ppm
ppm
g) 0.037 tor- 0.0326
ppm
h) 0.028 tor- 0.0214
PPi
i) 0.034 tor- 0.0349
ppm
j) 0.025 tor1- 0.0168
PPm
_
a) 17.1 o - 15.8 ppb
b) 12.9 0-7.7 ppb
c) 23.'6 0-21.4 ppb
a) 13.7 o - 24.7 ppb
e) 16.5 0-15.7 ppb
f) 17.5 o - 16.9 ppb
g) 18.9 o - 17.6 ppb
GENERAL INFOBHATICH
t) ^ season of prioc exposure
c) 2 seasons of prior exposure
g) Group b) , post-exposure
h) Group c) , post-exposure
i) Group d) , post-exposure
j) Group e) , post-exposure
f)-j) After 16 vk spraying technical
grade HC9 (3. IK alpha, .7* beta, and
U gamma) , applied vith pump (20
mq/sq ft)
19-49 yr old malaria spraymen with
0-4 seasons prior occupational
exposure
ADOLTS; BLOOD SEE OB; CHLORINATED
HYDROCABBOHS; CHLORINE ORGANIC
COBPOONOS; HEXlCHLOBOCTCLOHEItHE;
PESTICIDES; OCCUPATIONAL BAZABDS;
PESTICIDE BESIDDES
a) ill subjects
t) 60 subjects agec '3 25 yr
c) 40 subjects ages 26-3" yr
d) 42 subjects vegetarians
e) 58 subjects non-vegetarians
f) 03 subjects rural
g) 57 subjects urban
Tissue collected at delivery
t) and c) significantly different
Residents of Lncknow, India
INDIA: ADOLTS; AGE; FETUS; BLOOD;
PLACENTA; CBLOHINE ORGANIC COBPODNDS;
DCT; DDE; DDT; HfliCHLOROCTCLOB IIANE;
IIIDAHE; PESTICIDES; AGRICOLTORE;
EIOACCOBOLATION; DIETS; PREGJANCt;
FDEAL AREAS; OEBAN ABE AS; PESTICIDE
RESIDUES ; POPOLATIOS EXPOSDBE
E8FEBENCE
Parikh, J.6.
Shah, n.P.
Chatter jee, s. K.
1982
Archives of
Environmental Health
37(1): 4 1-44
Saxena, B.C.
Siddiqui, U.K. J.
Bhargava^ A.K.
Krishna (lurti, C.B.
Itotty, D.
1981
Archives of Toxicology
48:127-134
1
O
o
Cyclohexanol
108-93-0
C6-H12-0
ns 100.16, HP 24 c, BP 161.5 C, VP 1 mm Bg at 21.0 C
6320
Breath
EXPOSURE BOOTS
ASALITICAL
HETHOD
HOHEEH
OF CASES
2.3-8.7 ng/1
4.3 ng/1
GESERAL IHFOBBATION
Estimated from graph
Healthy 18'60 yc olds, nonamokers.
Bigid protocol 14 days before and
during study to minimize number and
amount of exogenous constituents.
ACOLTS; BREATH; ALCOHOLS; CHLOBIBE
08GAIIC COSPOONDS; CRLOROB IIZEBES
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, B.
Claudio, B.P.A.
1977
Journal of
Chromatographic Science
15:239-244
-------
Cyclcpentanol
96-11-3
C?-H10-0
B» 86.13. BP -19 C, BP 139.5 C
TISSUE
6321
Breath
EXPOSURE ROUTE
ANALYTICAL
(IETBOD
oc/ns
NU9BER
OF CASES
28
BADGE
0.2-3.2 ng/1
HEAN
0.8 ng/1
GENERAL IBFORBATION
IstiBated from graph
Bealthy 18-60 yr olds* nonsaokers.
during stud? to liniiize nuiber and
avount of exogeneous constituents.
AEDLTS; BBEATB; ALCOHOLS; CHLORINE
ORGANIC COBPOUNDS; CBLOROBENZENES
BEFEBBNCE
Krotoszynski, 8.
Gabriel, G.
O'Neill, H.
Claudio, B. p. A.
1977
Journal of
ChrOBatographic Science
15:239-244
DDT, total |»o postings in CHEMISE) .
50-29-3
C14-H9-C15
MS 3511.50
TISSUE
6322
Adipose
6323
Blood
EXPOSURE ROUTE
^
ANALYTICAL
1ETHOD
GC
GC
NUREER
OF CASES
a) 19
b) 9
c| 9
100
GAUGE
a) 2.19-148.63 ug/g
b) 1.45-15.35 ng/g
c) Not detected-8.04 ag/g
a) 7.7- 1257.3 ppb
b) Hot given
c) sot given
d) Not given
e) Hot given
f) Not given
g) Not given
HE AN
_
a) 21.47 *or- 37. 10
uj/g
b) 8.31 »or- 1.95
ug/g
c) 3.44 *or- 3.25
ug/g
a) 47.2 tor- 52.2 ppb
b) 42. 1 tor- 38.5 ppb
c) 56.1 tor- 86. J ppb
d) 41.6 tor- 44.2 ppb
e) 72.1 tor- 183.4
ppb
£) 87.2 tor- 217.8
PPb
g) 55.4 tor- 52.4 ppo
GENERAL IHFORflATIOK
a) Torreon, Mexico. Agricultural
region with high pesticide use
b) Mexico City. Pesticide exposure
•ainly froa foods shipped in froi
ether areas
c) Puebla. Industrial and
traditional agricultural region with
lew pesticide use
Hondetectable levels^O.OOS ug/g
Residents of Nexico
HEXICC; AOTOPSIES; ADIPOSE IISSOE;
SURGERY; CHLORIHATEE H YDROCARBOSS;
CBLOBIHE ORGANIC COBPODNDS ; ODD: DDE;
DET; DIELDGIN; HEXACHLOROC TCLOHEXANE :
IISDANE; PESTICIDES: PESTICIDE
BISIDDES; POPULATION EXPOSURE; URBAN
AREAS
a) All subjects
b) 60 subjects, ages 18-25 yr
c) 40 subjects, ages 26-34 yr
d) 42 subjects, vegetarians
e) 58 subjects, non-vegetarians
f) 43 subjects, rural
g) 57 subjects, urban
SUB of p,p'-DDE, p, p»-DDD, and
p,p»-DDT
Haternal bleed, collected 8-12 br
before parturiticn
Residents of Lucknow, India
INDIA; ADULTS; AGE; FETUS; BLOOI;
PLACENTA; CHLORINE ORGANIC COBPOONDS;
DEE; DDE; DOT; HEIACHLOROC YCLOH EKA NE;
LINDANE; PESTICIDES; AGRICULTURE;
BIOACCUBULATION; DIETS; PREGNANCY;
RURAL AREAS; URBAN AREAS; PESTICIDE
RESIDUES; POPULATION EXPOSURE
REFERENCE
Albert, L.
Hendez, F.
cebrian, K. E.
portales, A.
1980
Archives of
Environmental Health
35(5) : 262-269
Saxena, B.C.
Siddigui, H.K.J.
Bhargava, A.K.
Krishna Hnrti, C.R.
Kutty, D.
1981
Archives of Toxicology
48:127-134
(BEiT PAGE)
-------
DDT, total (Ho postings in CHEHLINE).
50-29-3
C11-H9-C15
H« 354. 50
(CONTINUED)
TISSUE
6324
Blood,
fetal
6325
Blood,
serua
6326
Placenta
EXPOSURE ROUTE
.
ANALYTICAL
METHOD
GC
GC
GC
NUBBER
OF CASES
100
199
100
RANGE
a) 2.7-1029.8 ppb
b) Hot
c) Sot
d) Hot
e) Hot
f) Not
g) Hot
a) Hot
b) Hot
c) Hot
d) Hot
e) Hot
f) Hot
g) Hot
h) Not
i) Not
j) Hot
«) Not
1) Hot
») Hot
n) Hot
o) Hot
P) Hot
a) Hot
b) Hot
c) Hot
d) Hot
e) Hot
f) Hot
g) Hot
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
gi en
detected-298.7 ppb
given
given
given
given
given
given
BEAN
a) 50.7 +or-
ppb
b) 49.5 *or-
ppb
c) 51.1 tor—
d) 62.2 »or-
f) 10.6 tor-
g) 41.6 +or-
a) 25 ug/1
b) 26 ug/1
c) 35 ug/1
d) 16 ug/1
e) 50 ug/1
f) 112 ug/1
g) 62 ug/1
h) 113 ug/1
l) 100 ug/1
j) 252- ug/1
k) 180 ug/1
J.) 220 ug/1
m) 160 ug/1
n) 195 ug/1
o) 285 ug/1
P) 375 ug/1
Geometric
a) 56.2 0 -
b) 51.1 o -
c) 63.8 o -
d) 57.7 o -
e) 73.6 0 -
f) 75.7 o -
g) 58.1 or-
117.0
173.7
51.0 ppb
53. 1 ppb
72.1 ppb
51.6 ppb
18.3 ppb
56.9 ppb
59.4 ppb
73.7 ppb
70.7 ppb
12.4 ppb
GENERAL INFORBATION
a) All subjects
b) 56 subjects. Bother's age 18-25 yr
c) 31 subjects. Bother's age 26-34 yr
d) 36 subjects, vegetarian Bothers
aethers
g) 18 subjects, urban
SUB of p,p'-DDE, p,p'-DDD, p,p'-DDT
Cord blood, collected at delivery
Residents of Lucknow, India
INDIA; ADULTS; AGE; FETUS; BLOOD;
PLACENTA; CHLORINE ORGANIC COBPOUHDS;
DEC; DDE; DCT; HEIACHLOROCYCLOHIXANE;
LINDANE; PESTICIDES; AGRICULTURE;
BIOACCUHULATION; DIETS; PREGNANCY;
BUBAL AREAS; URBAN ABEAS; PESTICIDE
RESIDUES: POPULATION EXPOSURE
a) Feaales age or= 70
p) Bales >or- 70
Estiaated froa graph
Levels increased with age. Fish
consuaption was second strongest
aeterainant.
Residents of Triana, AL living
DDT-Banufacturing plant. 43.8* Bale,
56.2* feaale, 86.9* black, 361
children.
BLOOD SERUB; COB PAR ATI VE EVALUATIONS;
INDUSTRIAL PLANTS; HETABOL1TES; DDT;
ALtBABA; ADOLESCENTS; ADULTS;
CHILDREN; INFANTS
a) All subjects
b) 60 subjects ages 18-25 yr
c) 40 subjects ages 26-34 yr
d) 42 subjects vegetarians
e) 58 subjects non-vegetarians
f) 43 subjects rural
gl 57 subjects urban
SUB of p,p'-DDE, p,p'-DDD, and
p,p'-DDT
Tissue collected at delivery
Residents of Lucknow, India
INDIA; ADDLTS; AGE; FETUS; BLOOD;
PLACENTA: CBLORINE ORGAHIC COHPOUNDS;
DEE; DDE; DDT; HEIACHLOROCYCLOBIXANE;
LINDANE; PESTICIDES; AGRICULTURE;
EIOACCUnULATIOH; DIETS; PREGBAHCI;
BDRAL AREAS; ORB II » AREAS; PESTICIDE
RESIDUES; POPULATION EXPOSURE
REFERENCE
Saiena, B.C.
Siddigui, B.K.J.
Bhargava, A.K.
Krishna Burti, C.R.
Kutty, D.
1981
48:127-134
Kreiss, K.
zack, fl.B.
Kiabrough, R.D.
Needhai, L.L.
Sirek, A.L.
Jones, B.T.
1981
>gy
Journal of the American
nedical Association
245(19) :1926-1930
Saxena, B.C.
Siddigui, H.K. J.
Bhargava, A.K.
Krishna Hnrti, C.R.
Kutty, D.
1981
Archives of Toxicology
48:127-134
-------
Decanal
112-31-2
C10-B20-0
fV 156.27, NP -5 C, BP 208-209 C, If 1 »» Hg at 51.9 C
TISSDB
6327
Breath
EXPOSURE ROUTE
ANALYTICAL
HETHOD
GC/«!S
SDMBBB
OF CASES
28
BASSE
0.2.2-1 ng/1
BEAN
0.47 ng/1
GENERAL INFORBATICN
Estimated from graph
Health? 18-60 yr olds, nonsmckers.
Rigid protocol 14 days before and
during study to liniiize nuaber and
ADULTS: BREATH; ALCOBOIS; CHLOBINE
OEGIBIC COHSOUHDS; CHLOBOBIHZEI1IS
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, n. P. A.
1977
Chroaatographic Science
15:239-2«l|
Cecane
12U-18-5
C10-B22
UK 1»2.3, HP -29.7 C, BP 1711. 1 C, TP 1 III Hg at 16.5 C
TISSUE
6328
Breath
EXPOSURE P001E
ANALYTICAL
HETHOD
GC/HS
NUMBER
OF CASES
28
BADGE
0.01-3.5 ng/1
MEAN
0.37 ng/1
GBSF.RAI I8FOEJ1ATIOH
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 11 days before and
during study to minimize number and
amount of exogenous constituents.
ACOLTS; BREATH: ALCOHOLS; CHLORINE
ORGANIC COMPOUNDS; CHLOBOBENZENES
BEFEBENCE
.
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, H. P. A.
1977
Journal of
Chromatographic Science
15:239-211
M
O
U>
Eibutylamine (8 CI)
1-Butanamine, n-butyl- (9 CI)
111-92-2
C8-H19-N
BS 129.21, BP -60 to -59 C, BP 159-160 C, VP 2 ma Hg at 20 C
6329
Breath
EIPOSORE E017TE
ASALYTICAI.
HETHOD
GC/KS
SJHBEP,
OF CASES
28
BAHGE
0.08-1.2 og/1
__..
flEAN
0.32 og/1
GENERAL MFORHATION
Estimated fron graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 11 days before and
a fount of eiogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COBPOUUDS; CHLOROBINZENES
REFERENCE
Kiotoszynsltl, B.
Gabriel, G.
O'Neill, H.
Claudio, n.P.A.
1977
Chromatographic Science
15:239-211
-------
Ccdecane
112-40-3
C12-H26
BV 170.3, HP -12 C, BP 216.2 C, »p 1 in Hg at 47.8 C
TISSOE
6330
Breath
D00481 (No p
TISS0E
6331
Orine
EXPOSORE BOOTE
ASALYTICAL
HETHOD
GC/HS
MOBBEB
OF CASES
28
BADGE
0.09-1.2 ng/1
BEAN
0.32 ng/1
GENERAL INFORMATION
Estinated fro» graph
Healthy 18-60 ?c olds, noitSBOkers.
during stud; to ilniiize nuaber and
aiount of exogenous constituents.
ADDLTS; BBE4TH; ALCOHOLS; CHLOBIHE
OBGAMIC COHPOUHDS; CHLOROBEHZEMES
REFERENCE
K rotosz ynski, E.
G a br ie 1 , G .
O'Neill, R.
Claudio, fl.P.A.
1977
Journal of
Chronatographic Science
15:239-24«
stings in CHEMLINE) .
ETPOS0BE KOOTE
Ingestion
ANAITTKAL
HE! HOD
Badiouetry
NOHB Eft
OF CASES
6
BANGE
0.032-0.054% of dose
HEAN
0.041 *or- Q.0105S of
dose
GENERAL INFOBfl&TIOH
7 day emulative excretion after 50
aCi dose. fecal recovery after 7
days was 9t.3 +or- 1.9K
ORIMB; FOOD ADDITIVES
BEFE HENCE
Walson, P.O.
Carter, D-E.
Eyerson, B. A.
Clark, D.
1981
Food and Cosaetics
Toxicology 19:687-690
C00607 (no postings in CHEBLIHE).
TISSDE
6332
EXPOSURE BOtJTE
Ingestion
ANALYTICAL
Badioietry
_
N OH BEE
OF CASES
6
BANGE
0.031-0.088% of dose
MEAH
0.045 +or- 0.021% Of
- -
GESEBAL IIFOBBATIOH
7 day cumulative excretion after 50
»or- 1.7% after 7 days indicates
• iniaal intestinal absorption
Healthy 22-32 yr olds
OBIHE; FOOD ADDITIVES
BBFEBENCE
liaison, P.O.
Byerson, B. A.
clarX, D.
1981
Food and Cosaetics
Toxicology 19:687-690
Irgosta-5,22-dien-3beta-ol (8 CI)
Ergosta-5,22-(3ien-3-ol, (3fceta, 22E) - (9 CI)
H74-67-9
C28-B46-0
fl! 398.74
TISSUE
6333
Blood,
cells
EXPOSORE BOOTE
Ingestion
ANALYTICAL
HETHOD
ILC
GC/BS
HOUSES
OF CASES
3
RANGE
1.3-2.9 ug/g
BEAU
2.2 ug/g
GZIERAl KFOBIiATICH
Tctal noncholesterol sterols in diet,
393 >g/day for 3-D »k (2 subjects) or
8 wk (1 subject). Total sterols in
diet, 634 Bg/day
2 coraal ien, one 66 yr old
AEOLTS; BLCOD PLASH*: BEYTBBOCTTES ;
CBOLESTEROLS; DIETS; FOODS
REFERENCE
Connor, H.E.
Lin, D.S.
1981
Gastroenterology
81:276-284
(KEIT PASS)
-------
Ergosta-5,22-dien-3beta-ol (8 CI)
Ergosta-5,22-dlen-3-ol, (3beta,22B)- (9 CI)
474-67-9
C28-H46-0
KB 398.74
(COHTIBOED)
TISSUE
Blood,
EXPOSURE ROUTE
ANALYTICAL
HETHOD
GC/HS
NOMBEB
OF CASES
BANGE
MEAN
GENERAL IHFOEflMICH
282 Bg/day for 3-«( trie (6 subjects) or
8 wk (1 subject) . Total sterols in
diet, 017 »g/day or 631 »g/dar
8 no rial 23-H7 yr old «en, 1
hypercholesteroleaic 66 yr old HO* an
6DT1LTS; BLOOD PLASHA; EETTfiBOCTTES ;
CHOLESTEROLS; DIETS; FOODS
REFERENCE
Lin, D.S.
Cast roe nterology
81:276-284
Erqosta-5,2H (28)-dien-3beta-ol (8 CI)
Erqosta-5,2U(28)-dien-3-ol (3beta)- (9 CI)
U7K-63-5
C28-HU6-0
8« 398.74
6335
Blood,
cells
6336
Blood,
plasma
EXPOSURE BOtllE
Ingestion
IngestioD
AKA1YTIC4L
BETHOD
TIC
GC/HS
ILC
sc/ns
NUMBER
OF CASES
3
9
RANGE
7.2-12.3 ug/g
5.2-51.0 ug/ml
HE AN
9. 1 ug/g
15.6 ug/ml
GENERAL IHFOEHATIOH
1
393 «g/day (or 3-« wk (2 subjects) or
diet, 634 Bg/day
1DOLTS; BLOOD PLISHA; EBTTDROCYIES ;
CBOLESTEBOlSj DIETS; FOODS
282 «g/daf for 3-1 Kit (6 sab-)ects| or
393 »g/day for 3-tt wk (2 subjects) or
8 wk (1 subject). Total sterols in
diet, UU1 ig/day or 631 «g/day
8 normal 23-47 yr old Ben, 1
hypercholesterolemic 66 yr old woaan
»D01TS: BLOOD PLJSfli; ERTTHROCIIES;
CHOLESTEROLS; DIBTS; FOODS
- -
REFEREMCE
Lin, D.S.
1981
Gastroenterology
81:276-2811
Lin, D.S.
1981
Gastroenterology
81:276-284
-------
Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2- (p-chlorophenyl)- (8 CI)
Benzene, l-chloro-2- (2,2-dichLoro-1- (4-chlorophenyl) et hyl)- (9 CI)
53-19-0
53-19-0
C11-HIO-C14
«» 320.U5, HP 76-78 C
TISSDE
6337
Blood,
plasma
EJPOSn-RE ROUTE
Ingestion
ANALYTICAL
HETHOD
GC
HDHBER
OF CASES
RANGE
a) Not given
b) Not given
c) Hot given
d) Not given
e) Not given
f) 3.8-9.8 ug/nl
g) 7-16.5 ug/ul
h) 8.5-23 ug/nl
MEAN
a) 2.8 ug/ml
c) 3.0 ug/nl
a) 1.7 ug/ml
e) 0.5 ug/ml
f) 6. 1 ug/ml
g) 12 ug/ml
h) 16.2 ug/al
GEHEBAL IHfOBHATICN
a) In milk, 1H patients
c) ID granules, 12 patients
d) In tablets, 9 patients
e) In peanut oil/water emulsion, 6
patients
f ) In tablets, 8 patients
g) In peanut oil/water emulsion, 8
patients
h) In milk, 6 patients
a)-e) mean levels in first 10 hr
period after 2 g. 5 hr levels also
given
£)-h) 1.75-4 g/day for 30-60 days.
total dose 200 g
d) significantly lover than a), b) ,
and c) but significantly higher than
e)
f) Significantly lower than g) and h)
Estimated from graph
Patients treated foe disseminated
adrenocortical cancer or pituitary
dependent Gushing 's syndrome, Leiden,
The Netherlands
Nausea and borborygnus vhen
administered in chocolate cr emulsion
HETHE8LANCS; DISEASES; SARCOMAS;
BICOD PLASHA; DROG THERAPY; DB3GS;
CCHPARATIVE EV/ALDATJOHS;
CHEHOTBERAPI; ODD
REFERENCE
Boolenaar. A. J.
van Slooten, H.
van Seters, A. P.
Saeenk, D.
1981
Cancer chenotherapy and
Phar»acology 7:51-54
Ethane, 1,1-dichloro-2 ,2-bis(p-chlorphenyl} - (8 CI)
Benzene, 1, I1- (2, 2-dichlocoethylidene) bis (i|-chLoco- (9 CI)
72-5H-8
C1»-H10-cla
B8 350.«6, flP 221-222 C
6338
Adipose
EXPOSDBE BOOIE
ANALYTICAL
HETHOD
NOHBEB
OF CASES
a) 19
b) 9
c) 9
BANSE
a) Not detected- 1.03 ug/g
b) d. 04-1. 63 ug/g
c) Not detected-0.01 ug/g
HEAN
a) 0. 16 tor- 0.26
ug/g
b) 0.11 +or- 0.72
ug/g
c) Not given
(SEM
GENERAL INFOBBATICN
a) Torreoo, Hexico. Aqricultaral
region vith high pesticide use (9
saiples >0.01 ug/g)
t) Mexico City. Pesticide exposure
lainly fron foods shipped in froi
other areas (B samples >0.01 ug/9)
c) Pu«bla. Industrial and
traditional agricultural region vith
lev pesticide use
levels based on extractable lipids.
Nondetectable lev«ls*0.005 ag/g
Residents of Mexico
SEXICO; 1DTOPSIES; MJIPOSE 1ISSOE;
SOEGEBI; tBLOHISATED HIDBOCAEBONS;
CB10BINE OEG1HIC COBPOONOS; ODD; DOE;
CET; DIELDRIB; flEMCBLOSOCTCLOBIIME;
LIHDXE; PESTICIDES ; PESTICIDE
BESIDDES; POPDLATIOK EIPOSDBE; OEBAN
ABEAS
Albert, L.
nendez. t.
cebrian, H. E.
Portales, A.
1980
Archives of
Environmental Health
35(S):262-269
-------
Ethane, 1 , l-dichloro-2, 2-bis (p-chlorphenyl) - (8 CI)
Benzene, 1,V-(2,2-dichloroethylidene)bis(4-chloro- (9 CI)
72-51-8
C14-H10-C14
B» 350.46, HP 221-222 C
(CONTINUED)
TISSUE
Blood
63«0
Blood,
fetal
63H1
Placenta
EXPOSURE FOOTS
ANALYTICAL
HETHOD
GC
GC
cTOMBEE
OF CASES
too
,
100
BASSE
b) Hot given
c) Not given
d) Hot given
e) Sot given
f) Hot given
g) Not given
. _ .
aj Hot detected-48.2 ppb
b) Hot given
C) Wot given
d) Not given
e) Hot given
£> Hot given
g) Not given
a) Not detected-93.3 ppb
b) Not given
c) Not given
d) Not given
e) Hot given
f) Not given
MEAN
D) 4.9 +or- 7.7 ppb
c) 7.U +or- 8.2 ppb
d) 1.8 +or- 6.7 ppb
e) 15.7 +or- 62. 1 fpb
f) 18.9 +or- 9.5 ppb
g) 8.2 +or- 9.5 ppb
a) 7. 1 0-16.1 ppb
b) 5.8 0-9.2 ppb
c) 8.0 o - 14.8 ppb
d) 6.5 0-11.1 ppb
e) 8.4 0-11.6 ppb
f) 6.2 o - 9. 4 ppb
g) 7.3 o - 25.7 ppb
a) 8.3+0-9.9 ppb
b} 9.0+0- 11.3 ppb
c) 7,1 +o - 7 . 5 ppb
3) 7. 1 +o - 9.8 ppb
e) 10.5 + r- 15.9 p^b
£} 12.7 + r- 17.2 ppb
GENERAL INFOEtlATION
. ._.
fc) 60 subjects, age 18-25 yr
c) «0 subjects, age 26-34 yr
d) 42 subjects, vegetarians
e) 58 subjects, non-vegetarians
f) 113 subjects, rnral
g) 57 subjects, urban
Maternal blood, collected 8-12 hr
before parturition
1) and c) significantly different
Residents of Lucknov, India
INDIA; ADULTS; AGE; FETUS; BLOOD;
PLACENTA; CHLORINE ORGANIC COflPCUSDS;
DCD; DDE; DDT; HEXACHLOROCICLOHIXANE;
LINDANE; PESTICIDES; AGRICULTURE;
BIOACCUflBLATIOH; DIETS; PBESKABCY;
EURAL AREAS; URBAN AREAS
a) All subjects
b) 56 subjects, Bother's age 18-25 yr
c) 31 subjects, pother's age 26-31 yr
d) 36 subjects, vegetarian nothers
e) 54 subjects, non-vegetarian
i ethers
f) »2 subjects, rural
g) 48 subjects, urban
Ccrd" blood, collected at delive'ry
INDIA; ADULTS; AGE; FETDS; BLOOD!
PLACENTA; CBLORIBE ORGANIC COHPCDNDS;
Dtt: DDE: DDT: HEXACHLOROCYC10HIIAHE;
LINDABE; PESTICIDES; AGRICULTURE;
BIOACCOHULJTION: DIETS: PREGNANCY;
RURAL AREAS; URBAN AREAS; PESTICIDE
RESIDUES: POPULATION EXPOSURE
a) All subjects
t) 60 subjects, ages 18-25 yr
c) 40 subjects, ages 26-34 yr
d) 42 subjects, vegetarians
e) 58 subjects, non-vegetarians
f) «3 subjects, rural
Tissue collected at delivery
d) and e) , f) and g) significantly
different
Residents of Lucknow, India
INDIA; ADULTS; AGE: FETUS; BLOOD;
PLACENTA; CHLORINE ORGANIC COHPCUHDS;
DCt; DDE; DOT; HEXACBLOROCYCLOBIXANE;
LISDANE: PESTICIDES; AGRICULTURE;
BIOACCUBULATIOK; DIETS; PRESNANCY;
RURAL AREAS; URBAN AREAS; PESTICIDE
RESIDUES; POPULATION EXPOSUEE
REFERENCE
Siddigui, Pt.K.J.
Bhargava, A.K.
Krishna flurti, C.R.
Kutty, D.
1981
Archives of Toxicology
48:127-134
Saxena, B.C.
Siddigui, H.K.J.
Bhargava, A*K*
Krishna Hurti, C.R.
Kutty, D.
1981
Archives of Toxicology
48:127-134
Saxena, N.C.
Siddigui, H.K.J.
Bbargava, A.K.
Krishna nurti, C.R.
Kutty, B.
1981
48:127-134
O
--J
-------
Ethane, 1. 1,1-trlchloro-2, 2-bis (p-chlorophenyl)- (8 CI)
Benzene, 1,It-(2,2,2-trichloroetliylidene)bis (4-chloro- (9 CI)
50-29-3
C14-H9-C15
US 354.50, MP 108.5-109 C, BP 260 C, VP 1.5110(6-7) » Hg at 20 C
TISSOE
6312
Adipose
6313
Blood
Blood,
fetal
EXPOSURE ROUTE
ANALtTICAL
METHOD
GC
GC
GC
HOIt BEE
OF CASES
a) 19
b) 9
c| 9
100
SINGE
a) Hot detected-2.54 ug/g
b) 0.21-3.54 ug/g
c) Sot detected- 3. 09 ug/g
a) Hot detected-433.6 ppb
b) Hot given
c) Sot given
d) Hot given
e) Hot given
f) Hot given
g) Hot given
b) Hot given
c) Hot given
d) Hot given
e) Hot given
f) Hot given
g) Hot given
MEAN
a| 0.82 tor- 0.89
ug/g
b) 1.08 toe- 1. 13
ug/g
c) 0.48 tor- 0.92
ug/g
a) 17.3 tor- 37.3 pp
b) 15.3 tor- 42.4 pp
c) 21.5 tor- 28.8 pp
d) 21.7 tor- 39.7 pp
e| 23.7 tor- 11.3 pp
f) 142.2 tor- 86.9 pp
g) 24.4 tor- 34.4 pp
b). 7.3 tor- 17.2 ppb
c) 22. 1 tor- 12.3 ppl
d) 14.8 tor- 18.3 ppi
e) 17.0 tor- 23.0 pp
f) 17.0 tor- 26.2 pp
g) 13.7 tor- 14.5 ppl
GESIRAL IHFORHATION
a) Torreon, Mexico. Agricultural
region with high pesticide use (12
saiples >0.01 ug/g)
b) Mexico city. Pesticide exposure
•ainly froa foods shipped in frca
ether areas (8 saiples >0.01 ug/g)
c) Puebla. Industrial and
traditional agricultural region vith
lew pesticide use (5 saaples >0.01
ug/g)
levels based on extractable lipids.
Ncndetectable levels=0.005 ug/g
Residents of Mexico
MEXICO; AUTOPSIES; ADIPOSE TISSUE;
SURGERY; CHLORINATED HYDROCARBONS;
CBtORIHE OBS»»IC COMPOUNDS; ODD; DDE:
DtT; CIELDRIN; 8EXACHLOEOCTCLOHZXANE:
1ISDANE; PESTICIDES; PESTICIDE
RESIDUES; POPULATION EXPOSURE; URBAN
AREAS
a) 111 subjects
b) 60 subjects, ages 18-25 yr
c) 40 subjects, ages 26-34 yr
d) 42 subjects, vegeta-riacs
e) 58 subjects, non-vegetarians
f) 43 subjects, rural
g) 57 subjects, urban
Maternal bleed, collected 8-12 hr
before parturition
f) and g) significantly different
Residents of Lucknov, India
INDIA; ADOltS; AGE; FETOS; B100D;
PLACENTA; CHLORINE ORGANIC COMPOUNDS;
ODD; DDE; DDT; HEIACHLOHOCICLOHflANE;
LINDASE; PESTICIDES; AGRICULTURE;
BIOACCUMOHTIOS; DIETS; PREGNiNCT;
RURAL AREAS; URBAN AREAS; PESTICIDE
RESIDUES; POPULATION EXPOSURE
a) All subjects
b) 56 subjects. Bother's age 16-25 yr
c) 34 subjects. Bother's age 26-34 yr
d) 36 subjects, vegetarian Bothers
e) 54 subjects, non-vegetarian
BCthers
f) 42 subjects, rural
g) 46 subjects, urban
Cord blood, collected at delivery
I) and c) significantly different
Residents of LUCKQOV, India
11DI1; ADULTS; AGE; TITUS; BLOOD;
ELACEHT1; CBLOEINE ORGANIC COMPOUNDS;
DDc; DDE; DDT; HEXACHLOROCTCLOB1I1NE;
LIBDANE; PESTICIDES; AGRICULTURE:
BIOACCUHULATIOH; DIETS; PREGNABCT;
RURAL AREAS: URBA» AREAS; PESTICIDE
RESIDUES; POPULATIOB EXPOSURE
Albert, L.
(lender, F.
Cebrian, M. E.
Portales, A.
1980
Archives of
Environaental Health
35(5):262-269
Saxena, H.C.
siddigui, M.K.J.
Bhargava, A.K.
Krishna nurti, c.R.
Kutty, D.
1981
Archives of Toxicology
48:127-134
O
OO
Saxena, B.C.
Siddigui. M.K.J.
Bhargava, A.K.
Krishna Murti, c.R.
Kutty, D.
1981
Archives of Toxicology
48:127-130
(SEXT PAGE)
-------
Ethane, 1,1,!-trichloro-2,2-bis(p-chloropheafl)- (8 CI)
Benzene, 1, I1- (2,2, 2-trichloroethylidene) bis (H-chloro- (9 CI)
50-29-3
C14-H9-C15
fl» 354.50, HP 108.5-109 C, 3P 260 c, VP 1.5X10(1-7) •• Hg at 20 C
(COHTINBED)
TISSUE
63U5
Placenta
EXPOSURE BOOTE
AHUTTICAL
BETHOD
SC
SOBBEE
OP CASES
100
BANGE
a) Not detected-93.3 ppb
b) Hot given
c) Not given
d) Not giveo
e) Hot given
f) Not given
g) Not given
(IE AH
a) 18.1
b) 14.6
dj 18.8
e) 20.7
f) 23.0
g) 20.9
to - 20.
to - 22.
to - 18.
to - 22.
to - 20.
8 ppb
2 Ppb
0 ppb
1 ppb
2 ppb
1 ppb
GENERAL INFORBATICH
a) til subjects
t) 60 subjects, ages 18-25 yr
d) 92 subjects, vegetarians
e) 58 subjects, non-vegetarians
f) 43 subjects, rural
Tissue collected at delivery
t) and c) significantly different
Residents of Lucknov, India
INDIA; ADOITS; AGE; FETOS; BLOOD;
PLACENTA; CBIORUE ORGANIC COHPOONDS;
DEI; DDE; DDT; HEI1CHIOROC TCLOH EI1NE;
LISDANE; PESTICIDES; ASRICOITOBE:
BJOACCDBOL4TIOII; DIETS; PRIGSIHCY;
Html »EE1S; OBBJN AREAS; PESTICIDE
BISID0ES; POPOLATIOH IIPOSDBE
EEPEBB»CE
Saxena, H.C.
Siddiqui, B.K.J.
Krishna nurti, C.B.
Kutty, D,
1981
18:127-1311
Ethyl alcohol (8 CI)
Ethanol (9 CI)
sa-n-'J
C2-H6-0
B9 H6.07, BP -117.3 C, BP 78.32 C, VP 10 in Hg at 19 C
TISSOE
63»6
Blood
63»7
Breath
EXPOSOBE ROOTE
Inhalation
iMilYTICAL
METHOD
OC
GC/HS
MOBBEB
OF CASES
10
28
BADGE
a) Not given
b) Not given
c) Hot given
d) Not given
4-15 ng/1
MEAN
a) 0.27 tor- 0.04 g/1
b) 0.75 tor- 0.07 g/1
c) 0.68 tor- 0. 10 g/1
d) 0.72 tor- 0. 18 g/1
7 ng/1
GENERAL INFOBHATICN
a) O.Q g/kg, 10 subjects
b) 0.8 g/kg, 10 subjects
c) 0.8 g/kg, 10 subjects
d) 0.8 g/kg, 10 subjects
Flean peak levels after single dose.
Healthy 21-26 yr olds, wt 65-82 kg
Psychophysiological functions
iipaired. Deleterious effects of
•-xylene and alcohol usually
additive. Antagonistic effects on
body balance at the higher xylene
level
FINLAHD; ADOLT5 ; BLOOD; DBOGS;
RICOHGLS; ALCOHOLIC BEVERAGES;
ITHOSPHEBB; INHALATION; SOLVENTS
Estimated from graph
Healthy 18-60 yr olds, nonsnokers.
Rigid protocol 1ft days before and
daring study to linieize nuaber and
aMount of exogenous constituents.
ALOLTS; BREATH; A1COHOLS; CHLORINE
CBGAHIC COMPOUNDS; CHLOROBEHZEN2S
Savolainen, K.
1980
Acta Pharaacologica et
Toiicologica
i»6 (5): 366-372
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, H.P.A.
1977
Journal of
Chronatographic Science
15:239-2U«
-------
Ethylene glycol, dinitrate (8 CI)
1,2-Ethanediol, dinitrate (9 CI)
628-96-6
C2-H4-N2-06
tin 152.07, HP -20 C, BP llll C (explodes)
TISSDE
63»8
Blood
6319
Orine
EltPOSORE ROUTE
Dermal
Deraial
ANALYTICAL
DETHOD
GC-EC
GC-EC
HOHBEH
OP CASES
16
3
GAUGE
a) 2-U5 ng/ul
b) 40- 123. 3 ng/Bl
_
4.3-37.7 ng/ml
.
BEAN
a) Not given
b) Not given
Not given
GENERAL INFORMATION
b) Horning and afternoon saiples,
every other day tor 5 days. Horning
levels generally higher. Gauge of
• cans
Data also by sex and occupation
Workers at dynamite factory, Japan
Fall in blood pressures, headaches
INDDSTEIiL CBEHICM.S; JAPAN; SEX;
BLOOD; OBIHE; HITBATES; BLCOD
PEESSORE; HEALTH HAZARDS; INDUSTRIES;
OCCUPATIONAL HAZARDS
Horning and afternoon samples, every
other day for 5 days
Range of leans
F-all in blood pressures, headaches
INDUSTRIAL CHEHICALS; JAPAN; SEX;
BLOOD; DRINE; NITRATES; BLCOD
PRESSURE; HEALTH HAZARDS; INDUSTRIES;
OCCUPATIONAL HAZARDS
BEFERENCE
Pukuchi, T.
1981
International Archives
of Occupational and
Environiental Health
18:339-346
Fukuchi, T.
1981
International Archives
of Occupational and
«8:339-3«6
5thylene, tetrachloro- (8 CI)
Ethene, tetcachloro- (9 CI)
127-18-H
C2-C1K
HB 165.85, BP 121 C
TISSUE
6350
Blood
6351
Brain
EXPOSURE BOOTS
Inhalation
Inhalation
A»»LYTICAL
BET HOD
GC/BS
GC/HS
HOBBEE
OP CASES
1
1
BASGE
.
Not given
Hot given
HE AN
4.4 mg/100 ml
36 mg/100 g
GEHEKIL IKFORnHTICH
Autopsy. Acute exposure in dry
other drugs negative.
33 yr old
AUTOPSIES; CASE HISTORIES; BLOOD;
EEAIN; LONGS; CHLOEIS4TED
HTDBOCA8BOHS
Autopsy. Acute exposure in dry
cleaning machine. Tests for levels
negative. Tests for alcohol and
other drugs negative.
33 yr old
AUTOPSIES: CASE HISTORIES; BLOOD;
BEAIR; LONGS; CHLOBIHATED
HYDROCARBONS
REFERENCE
Lukaszeitski, T.
1979
Clinical Toxicology
15(») :« 1t-H 15
Lukaszeiski, T.
1979
clinical Toxicology
15(4):il11-i*15
(NEXT PAGE)
-------
rthylene, tetrachloro- (8 CI)
Ethene, tetrachloro- (9 CI)
127-18-H
C2-C1H
MB 165.85, BP 121 C
(CONTINUED)
TISSUE
Long
6353
filk
635H
Urine
EXPOSURE ROUTE
Inhalation
1
ANALYTICAL
METHOD
GC/HS
HDNBEB
OF CASES
H2
34
BANGE
._._.
a) 0.9-6.3 ng/ml
b) 4.0-43 ng/ffll
c) 0.7-26 ng/ffll
d> 0.1-2.5 ng/ml
e) 0.4->19 ng/ml
f) 0.1-43 ag/ffil
a) < 50 019/1
b) 50-100 mg/1
c) 50-170 mg/1
MEAN
0.3 Dig/100 g
a) 2.52 +or- 2.13
ng/inl
b] 15.9 +or- 15.9
rig/ti
c) 3.41 +or- 7. 13
ng/ml
d) 0.79 +or- 0.75
ng/ml
e) 3.21 +or- 6.02
ng/ml
rig /ml
d.} Not given
b) Not given
c) Not given
GEHERM, IHFOBSITIOS
cleaning Machine. Tests foe levels
negative. Tests for alcohol and
other drags negative.
33 yc old
AUTOPSIES; CASE BISTOEIES; BLOOD;
EEAIH; LUBGS; CHIOBIBATED
HYDEOCABBOBS
a) Bayonne, NJ, 6 saaples
b) Jersey city, NJ, 5 samples
c) Pittsbnrgh, PA, 12 saiples
d) Baton Rouge, LA, 10 sanples
e) Charleston, HV, 9 sanples
f) Total a)-«)
Dae to saall sanple size and
Study neasured environaental
lilk in pollutant studies near
chemical manufacturing plants and/or
industrial facilities. Additional
data, U.S. and foreign, reviewed.
For additional information contact
Environmental protection Agency,
Exposure Evaluation Division, Office
of Toxic Substances, Washington, DC
20161
Lactating volunteers, residing in
during preceding wk
LOUISIANA; NEB JERSEY; PENNSYLVANIA;
BEST VIRGINIA; ADULTS; HILK;
HEASDREBENT flBTBODS; BENZENES;
CBLORINATED HYDROCARBONS;
CBLOROBENZENES; DDE; INDUSTRIAL
AEEAS; INDUSTRIAL EMISSIONS;
LACTATION: PESTICIDE RESIDUES; URBAN
AREAS; INDUSTRIAL CHEMICALS; SOLVENTS
a) 25 ppm or less in air
b) 25-75 ppn in air
c) 75-UOO ppm in air
No linear correlation, plateaa
reached at about 75 ppa
Setrachloroethylene workshop
employees.
JAPAN; URINE; CHLORINATED
HYDROCARBONS; INDUSTRIAL A1MOSPHEEES;
BHABOLITES; OCCUPATIONAL HAZARDS;
INDUSTRIAL CHEMICALS
BEFEREHCE
Lukaszewski
1979
15(11) :411-i415
Erickson, n.D.
Harris, B.S.H. , III
Pellizzari, E. D.
Tomer, K.B.
Vaddell, E. D.
Uhitaker, D.A.
1980
EPA 560/13-80-029. 153
pp.
_ , . .. ..
Ikeda, B.
1977
Environmental Healtn
Perspectives 21:239-245
-------
Ethylene, trichloro- (8 CI)
Ithene, trichloro- (9 CI)
79-01-6
C2-H-C13
H» 131. 10, HP 73 C, BP 87.1 C.
?p 100 II Hg at 32 C
TISSDE
6355
Breath
6356
Urine
EXPOSURE BODTE
Inhalation
AHALITICAL
HETHOD
GC
VDK BEG
OF CASES
20
51
BADGE
a) 59-1.9 ppi
b) 29-2. <4 ppm
c) 16-0.7 ppu
d) 2.8-0. 18 ppm
a) 0-0.9 »g/l
b) Hot given
c) Not given
a
b
c
0.01 ag/g
other areas (9 saiples >0. 01 ag/g)
c) puebla. Indastrial and traditional
agricaltaral region tilth lov
pesticide ase (7 saiples >0.01 og/g)
levels based on eitractable lipids.
Dondetectable levels'0.005 ag/g
Besidents of Mexico
HEItCO; AOTOPSIES; ADIPOSE TISSUE;
SOEGERT; CHLOBIIIATED HTDBOCABBOIS;
CBLO8ISE OBGAHIC COBPOOMDS; DDD; DDE;
DET; DIELDBH; HEIICHIOBOCICLOBEIAHE;
IIBDAHE; PESTICIDES; PISTICIDE
BESIDOES: POPnLATIOS EIPOSORE; OBBAH
ABIAS
BEPEBEHCE
Albert. L.
Hendez, r.
Cebrian, (I.E.
1980
Archives o£
Environaental Health
35 (5): 262-269
(BEIT PAGE)
-------
tthylene, 1,1-dichloro-2,2-bis (p-chlorophenyl)- (8 CI)
Benzene, 1, I1- (dichloroethenylidene) bic (4-chloro- (9 CI)
72-55-9
C14-B8-C14
B« 318.02, BP 88. 4 C
(CONTINUED)
Tissne
6358
Blood
6359
Blood,
fetal
6360
flilk
EXPOSURE ROUTE
ANALYTICAL
BETHOC
GC
GC
GC/BS
NUMBER
OP CASES
100
100
5
EA3GE
a) 2.0-324.8 ppb
b) Not given
c) Not given
d) Hot given
e) Not given
fj Mot given
g) Not given
a) 1.0-850 ppb
b) Hot given
c) Not given
d) Not given
e) Sot given
f) Hot given
g) Not given
a) 45-73 ng/ml
b) 38-101 ng/ml
c) 38-101 ng/ml
MEAN
a) 18.8 or- 19.6 ppb
D) 14.4 or- 19.2 ppb
c) 27.6 or- 38.5 ppb
d) 11.3 or- 13.9 ppb
e) 28.2 or- 50.7 ppb
f ) 23.6 or- 56. 9 ppb
g) 24.7 or- 31.4 ppb
a) 15.8 +o - 31.5 ppb
b) 12.3 +o - 8.8 ppo
c) 23. 1 +o - 24.6 ppb
ppb
e) 20.5+0-28,4 ppb
g) 22.8 +o - 46,7 ppb
a) 59 ng/ml
b) 78 ng/ml
c) 71 u g/m 1
GENERAL INFOBBATIOH
a) All subjects
b) 60 subjects, ages 18-25 yr
c) 40 subjects, ages 26-34 yr
d) 42 subjects, Yegetarians
e) 58 subjects, non-vegetarians
f) 43 subjects, rural
g) 57 cases, urban
Haternal blood, collected 8-12 hr
before parturiticn
b) and c) , d) and e) significantly
different
INDIA; ACDLIS: AGE; FETUS; BLOOD;
PLACENTA; CBLORINE ORGANIC COHPODNDS;
Dtt; DDE; DDT; HEXACHLOBOCYCLOHIXANE;
IIUDAHS; PZStlCIEJS; AGRICULTURE;
EIOACCUBDLJTION; DIETS; POEGHANCY;
10BJL AREAS; URBAN ABEJS: PESTICIDE
BESIDUES; POPULATION EXPOSURE
a) All subjects
b) 56 subjects, other's age 18-25 yr
c) 34 subjects, other's age 26-34 yr
e) 54 subjects, on-vegetarian
•ethers
g) 48 subjects, rban
Cord blood, collected at delivery
INDIA; AD01TS; AGE; TET0S; BLOOD;
PLACENTA: CBLOBIHE ORGANIC COMPOUNDS;
DDf, ODE; DDt; HEHCHLOEOCYCLOBUHE;
UHOAKE; PESTICIEES; IGRICDLTDRE;
BIOACCOnOLATIOH; DIETS; PREGHASCY;
BOEAL AREAS; ORBAN ABE AS; PESTICIDE
RISIDOES; POPDLATIOH EIPOSORE
a) Pittsburgh, PA, 2 saiples
b) Charleson, HT, 3 saiples
c) Total, a)-b)
Selected saiples
Lactating volunteers, residing in
area >12 BO, no travel out of area
during preceding vk
LOUISIANA; NEW JERSEY; PENHSIL7ANI A;
VEST VIRGINIA; ADDLTS; KILK;
(IIASOREHEIIT (IETHODS ; BENZENES;
CBLORINATED HYDROCARBONS;
CaLOBOBENZENES; DDE; INDUSTRIAL
AREAS; INDUSTRIAL EnlSSIONS;
LACTATION; PESTICIDE RESIDDES; URBAN
AREAS; INDUSTRIAL CHEBICALS; SOLVENTS
REFERENCE
Saiena, B.C.
siddigni, H.K.J.
Bhargava, A.K.
Krishna Burtl, C.B.
Kutty, D.
1981
Archives of Toxicology
48:127-134
Saxena, H.C.
siddigai, B.K.J.
Bhargava, A.R.
Kutty, D.
1981
48:127-134
Erickson, H.D.
Harris. B.S.H., III
Pellizzari, E. D.
Tover, K.B.
Daddell. R.D.
Khitaker, D.A.
1980
EPJ 560/13-80-029. 153
PF-
i
(NEXT PAGE)
-------
Ethylene, 1, l-dichloro-2,2-bis(p-chlorophenyl| - (8 CI)
Benzene, 1,1'-(dichloroethenylidene)bis(1-chloro- (9 CI)
72-55-9
C11-H8-C14
H» 318.02, 9P 88."I C
(CONTINUED)
TISSDE
>361
alacenta
EXPOSOBE BOOTS
SNALYTICAL
HETHOD
SC
HOHBEB
OF CASES
100
RANGE
a) Hot detected-234.7 ppb
b) Not given
c) Not given
d) Not given
e) Hot given
f) Not given g) Not given
_
BEAN
a) 22.0 o - 31.0 ppb
b) 16.0 o - 24.9 ppb
c) 31.3 o - 30.2 ppb
i) 27.5 o - H6.4 ppb
e) 32.9 o - 39.6 ppb
i) 30.6 o - U2.5 ppb
g) 29.3 o - 42.3 ppb
GENERAL INFOBHATICH
a) ill subjects
b) 60 subjects, ages 18-25 yr
c) 10 subjects, ages 26-34 yr
d> 12 subjects, vegetarians
e) 58 subjects, non-vegetarians
f) 43 subjects, rural
g) 57 subjects, urban
Tissue collected at deliver;
t) and c) significantly different
IHDIA; ACOITS; AGEi FETUS; BLOOD:
PUCEHTA; CflLOBHE ORG4HIC COHPOONDS;
DEC; DDK; DDT; HEXXCHI OROCtCLOB IXANE;
LINDANE; PESTICIDES; AGBICOI.TOBE;
BIOICCOHOIATIOH: DIETS; PBIGSJBCY;
BOB XL ABE AS; 'JBBAH IBEAS; PESTICIDE
RESIDUES; POPULATION EXPOSURE
BEFEBENCB
Saxena, fl.C.
Siddiqui, B.K.J.
Bhargava, A.K.
Krishna Surti, C.S.
Kutty, D.
1981
Archives of Toxicology
18: 127- 131
Ferritins
9007-73-2
EXACT COMPOSITION UNKNOWN OR UNDETERHINED
6362
Blood,
setum
6363
Bloo3,
serum
EXPOSOEE BOHIE
LYTICAL
ETHOD
NOHBEB
OF CASES
a) 6
b) 6
86
BANGE
a) 36.9-3409 ng/nl
b) 3.K-65.9 ng/«l
a) 17-350 ug/1
b) 21—270 Ug/1
c) 16-3UO ug/1
d) 26—170 ucT/1
e) 13-500 ug/1
f) 80-900 ug/1
g) Hot given
MEAN
a) 1286 ng/nl
b) 319 ng/ml
a) 90 ug/1
b) 100 ug/1
c) 75 ug/1
e) 235 *or- 51 ug/1
f) 290 »or- 72 ug/1
g) 333 »or- 199 ug/1
GEHERAL INFOHMATIOH
b) Subjects with nonal Fe stores
Seru» ferritin levels did not reflect
tissue Fe levels
liver biopsy best diagnostic Method.
Family with precirrhotic
be»ochro«atosis
CHELATING AGENT; GEMBTIC STUDIES;
CASE HISTORIES; LIVER DISEASES; HETAL
POISOBING; BXOOD SEBUB; LIVEB; DBIHE;
I BON
a) 38 Ethiopian Bothers
•can Fe intake 200 ag/day
Fe intake slightly leas than 200
•g/day
d) 10 Swedish mothers, Fe supplement
during pregnancy
e) Cord blood, 15 Ethiopian new born s
cf group c) mothers
f) Cord blood, 10 Swedish nevborns of
group d) mothers
g) Cord blood, 5 nevborns of
Fe-deficient group c) mothers
a) and d) differed, P<0.001. b) and
c) not significantly different.
Ethiopian non-privileged (mean age
19.7 yr) and privileged (mean age
23. 1 yr) mothers. Swedish mothers
(mean age 29.8 yr) . Ethiopian
privileged newborns (mean tit 3356 g.
•ean gestation 40.7 wk) . Swedish
ncwbocns (mean wt 3871 g, mean
gestation 39.4 vk).
ETHIOPIA; ADULTS; SREDEH; BEBBORH;
AHEflIB; BLOOD SEE OH; IBOH; BETAIS;
DIETS; FOODS; PBEGNAHCT
REFE HENCE
Pont, A.
Kands, J. R.
Carter, E.A.
Foster, G,
Kourides, I. A.
Isselbacher, K.J.
1977
New England Journal o£
fledicine
296(25) :1<(22-1»26
Gebre-nedhin, «.
Birgegard, G.
1981
Baenatology 27:217-252
-------
Fluoride
1698»-»8-8
F
AtB 18.9981
TISSUE
6361
Blood,
serum
6365
Teeth
6366
Urine
EXPOSURE ROUTE
Ingest ion
ANALYTICAL
METHOD
ISE
SOMBER
OF CASES
„
a) 51
b) 61
c| 71
a) 10
RANGE
0.011-0.076 ppm
a) Not given
b) Sot given
c) Sot given
a) Hot given
b) 2.5-2.9 mg/day
c) Sot given
d) Sot given
f) Not given
g) Sot given
h) Mot given
1
1
BEAN
0.051
a| 3,361 ppm
b) 1,179 ppm
c) 2,036 ppa
Adjusted for depth
a) 8.0 mg
b) Not given
c) 2.8 mg/day
d) 2.2 mg/day
f) 7.5 mg/day (51X)
g) 11.0 mg/day (56%}
h| 21.0 mg/day
(21. OX)
GENERAL INFORMATION
Rural Chinese
CHINA; BLOOC SEBOH; HEASOHEHENT
HETHODS; FLOOBIDE; FLOOBINE
COKP00NDS; RURAL AREAS
a) Sodiua fluoride Tarnish
(Duraphat) * 2.2% fluoride
t) Silane fluoride varnish (Fluor
Protector) , 0.7* fluoride
c) Ho topical fluoride treataent
Hinute portion of enaael dissolved
away to aeasure fluoride content
a) and b) 6 mo after 5th seal-annual
application (Bean nuaber
applications, 4.7)
Exposed to fluoridated drinking water
water (1.0-1.2 pri) since birth
Fluoridated toothpastes coaaonly used
(69*)
Fluoride content decreased with
increasing depth
a) and b) significantly different
13-15 yr olds, Finland
FINLAND; CHIIDBEN; TEETH; DENTISTRY;
IN VIVO ANALYSIS; FLOORIDE ;
BIOACCOHOIATION; DRINKING WATER;
POPULATION EXPOSURE
a) 18- day excess excretion after
retention of 114 og
b) 3.9-4.3 ag/day plus 200-2200
•g/day Ca and 80C-1400 ag/day p.
•g/day dose
c) Dose 4.4 »g/day for 26 days. Net
absorption 96t
d) Dose 5. 4 ag/day plus 30 al
aluainuB hydroxide for 22 days. Net
excretion of fluoride in feces
€) 4 ag/day for 28 days
f) 14 ag/day for 32 days
g) 25 ag/day for 90 days
h) 44 nig/day for 76 days
ACDLTS; FECES; URINE; COMPARATIVE
EVALOATIONS; REVIEW; FLOOSIDE
REFERENCE
Belisle, J.
1981
Science 212:1509-1510
Seppa, L.
Luoaa, B.
Hans en, H.
1982
Caries Research 16:7-11
Spencer, H.
osis, D.
Lender, H.
1981
Environment 17:1-12
Fluorine
7782-11-1
AtW 18.9981, HP -219.61 C, BP -188.13 C, VP 100 II Hg at -203 C
TISSUE
6367
Blood,
serun
EXPOSURE BOUTE
ASALYTICAL
METHOD
HDHBER
OF CASES
8
RANGE
0.003-0.017 ppn
8EAS
O.C106 ppm
GENERAL INFORMATION
Organic fon
Rural Chinese not exposed to
f luorocheiicals
CHINA; BLOOD SEROM; BEASOEEBENT
HETHODS; FLOORIDE; FLUORINE
CCBPOONDS; RURAL AREAS
DEFERENCE
Belisle, J.
1981
Science 212:1509-1510
i
1
(NEXT P4GE)
-------
Fluorine
7782-»l-il
F
AtB 18.99814, BP -219.61 C, BP -188.13 c. If 100 •• Hg at -203 C
(CONTINUED)
TISSDE
6368
Liver
EXPOSURE BODTE
imiYTICAL
BETHOD
NUBBBH
OF CASES
30
RANC
0.06-1. 4 ug/g
wet vt
Not given
GENERAL INFORBATION
Category 1 (first priority element)
en Honitoring Environmental Baterials
and Specimen Banking
Autopsies, Baltimore, HD,
ninneapolis, US, and Seattle, DA
BARYLAND: BlSNESOTA; 8ASHINSTOH :
ADTOPSIES; 1I»ER j HEA5DREI1ENT
PETHCDS; ALOBIHUB; ABTItlONY; ARSENIC;
EAEIBH; CADBIHB; CHBOHIOfl; COBALT;
COPPER; FLUORINE; IRON; LEAD;
KAIGAHESE; BESCOET; aoLTBDimi«;
NICKEL; RUBIDIIM; SELZSItlH; SILVER;
SIEOHIIOII; TBALLIDB; TIS; VANADIDB;
ZI1IC; POPntAIIOM EIPOSOBE
REFER EHCE
Harcison, S.H.
Vise, S.A.
1981
EPA 600/S1-81-025, 6
pp.
Furan
110-00-9
CO-Hil-0
B« 68.07, BP -85.65 C, BP 31.36 C
TISSUE
6369
Breath
EIPOSORE ROUTE
AHALTTICAL
BETHOD
SC/XS
HDBCEE
OF CASES
28
-
RANGE
0.27-3.6 ng/1
DEAN
1 ng/1
GEHEEAL IIFORHATIOX
Estimated £COM graph
Healthy 18-60 yr olds, nonsiokers.
Rigid protocol 14 days before and
during study to liniaize nuaber and
aaount of exogeneous constituents.
ADULTS; BREATH; ALCOHOLS; CBLOBIKE
ORGANIC COBPOOBDS; CRLOROBF.NZEIES
REFERENCE
Krotoszynski, B.
Gabriel, a.
O'Neill, H.
Claudio, B.P.I.
1977
Journal of
Chconatographic Science
15:239-21"
Olycerol (8 CD
1,2,3-Propanetriol (9 CI)
56-81-5
C3-H8-03
B» 92.09, BP 17.9 C (also reported as »19.8 C), BP 290 C, VP 0.0025 »« Hg at 50 C
TISSDE
6370
Blood,
serum
EXPOSURE ROUTE
Injection
__ .
ABA1YTICAL
BETHOD
Enzymatic
.._
NOB BEE
OF CASES
9
BEE
ASES
RANGE
1.48-5.83 mg/ml
HEAN
Not given
GEHERAL IIFOBHATION
Dose, 0.75-1.75 5/*9/2 hr.
Steady-state levels. AUC 191.9-672.6
mg/min/ml
9-20 yr olds vith Reye's syndrome
Temporary renal disfanction and
hemolysis in 2 patients
ADULTS; CHILDREN; BLOOD SEEUB; DBOG
TBERAPT; DBOGS
-
PEFE HENCE
Nahata, B.C.
Kerzner, B.
Hcclung, H. J.
Sherard, E.5.
Hilty, H.D.
1981
Clinical pharmacology
and Therapeutics
29(6):782-787
-------
Gcia
74HO-57-5
An
StW 196.9665, HP 1061.76 C, BP 2700 C, »p 1 >l Hg at 1869 C, 10 mm Hg at 2160 C
TISSUE
63 7 1
Hair
6372
Rair
EXPOSURE ROUTE
1UIITICAL
BETHOD
HA
_
HA
son DEE
OF CASES
Sfi
BAHGE
E-6) g/cu CD
a) 0.01-0.78 ppm
i>| 0.01-0.22 pp«
c) 0.01-0.64 ppm
BEAN
cm
a) 0.08 *or- 0. 12 ppu
b) 0.08 +oc- 0.06 ppm
c) 0. 14 +or- 0.14 ppm
GEHERAL IHFOBHITICtl
Same samples belov detection limits
IBIDIOn; H»IR; FOBESSIC HEDICIBE;
BEASOREHEHT BETHOOS; tlTIHCKT;
JESESIC; BROBIHE; COPPER; GOLD;
HBTH1BOB; BAHGASESE; BESCORI;
BITAIS; SELEHIOB: SILTED; SODIUB;
SIB08TIU9; ZIHC; IHDOSTRtAL
AIBOSEBERES
a) 12 cm length, 101 samples
b) Boot section, 18 samples
c) Distal section, 19 samples
Metropolitan BOBbay, India
INCH; JDOIISCESTS; ADOLIS : HAIR:
AHTIBOKI: ARSENIC; BROHIHE; CADBIUB;
CHLORINE: CBROalUn; COBALT; COPPER;
GOLD; lODIHt; IROS; LAKTHABOB;
BAHGABESE; POT1SSIOB; SCABDIUfl;
SELEHIUB; SILVER; SODIUB; ZIHC; AIR
tCLLDTION; EIO ACCOBDIATION ; FOSSIL
IDELED POWES PLAITS; IHDUSIRIAL
AREAS; IHDUSTRIAI ATROSPHEEES;
IHDOSTRIAL tfllSSIONS; INDUSTRIAL
POLLUTIOH; POPDLATIOS EXPOSURE; ORBA1I
ABEAS; ISDUSTRIAL CHEBICALS
D;bcZ7nslci, R.
Boboli, K.
1976
Journal of
Badioanalytical
Chemistry 31:267-289
Bhat, K.R.
Arunachalai, J.
Yegnasobraaanian, S.
Gangadharan, S.
1982
Science of the Total
Environment 22:169-178
Beiatite (8 CI)
Be»atite FFe203
317-60-8
e2-03
V 159.7
(9 CI)
TISSDE
6373
Lung
EXPOSURE ROUTE
Inhalation
AHALTTICAL
BETHOD
_
_
H09BEIJ
OF CASES
16
_
BAN5E
a) n. 15-10. 11X dry »t
b) 4.61-8.00)1 dry »t
c) 1.99-4.951 dry »t
d) 1. 11-2. 75X dry «t
.. _.
BEAN
d) Not given
b) Not given
c) Hot given
d) Not gzven
GENERAL IMFOBH&TION
a) Coaplicated pneu»oconiosis, large
•assive lesions
b) CORplicated pneuioconiosis,
•odecate passive lesions
c) Complicated pneuaoconiosis, soall
•assive lesions
d) Sinple penuaoconiosis, no massive
lesions
Eiposure levels not reported.
Feck liners
LONGS; IRON; METALS; HINIHG;
OCCUPATIONAL BAZAEDS
EEPEREHCE
Guest, L.
1981
analyst 106:663-675
-------
Heptane
112-82-5
C7-H16
B» 100.20, BP 98.52 c. If HO am Hg at 22.3 C
TISSUE
6371
Breath
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC/BS
NOBBER
OF CASES
28
RANGE
0.9-1.5 ng/1
MEAH
2.1 119/1
GENERAL INFOR BATICN
Estimated fron graph
Healthy 18-60 yr olds, nonsmokers.
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COHPOONDS; CHLOROBF.NZENES
REFERENCE
Krotoszynski, B.
Gabriel, S,
0'Heill, H.
Claudia, N.P. A.
Journal of
Chronatographic Scieace
15:239-21411
Heptane, 2,2-dimethyl-
1011-26-7
C9-H20
BB 128.25, DP -113 C, BP 130 C
TISSUE
6375
Breath
EXPOSURE ROOTE
ANALYTICAL
9ETHOD
SC/BS
BOBBER
OF CASES
28
BADGE
0.5-2.5 ng/1
HE AS
1 ng/1
GENERAL INFORMATION
Estiiated fron graph
Healthy 18-60 yr olds, non smokers.
Rigid protocol 1»i days before aad
during study to tiniaize nuiber and
A COLTS; BBEJTH; ALCOHOLS; CBLORINE
OBGIHIC COnPOUNDS: CHLOBOBESZINES
REFERENCB
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Clavidlo, n.P.l.
1977
Chrosatographic Science
15:239-214
00
Heptane, 2,1-dinethyl-
2213-23-2
C9-H20
US 128.26, BP 133.5 C
TISSOE
6376
Breath
EXPOSURE ROOTE
ANALYTICAL
METHOD
GC/BS
.
NOBBEB
OF CASES
28
RANGE
0.3-1.8 ng/1
..
HEAN
0.7 ng/1
GENERAL INFORBATION
Estimated fron graph
daring study to liniiize naiber and
ADULTS; BREATH; ALCOHOLS; CHLORISE
ORGANIC COHPOUHDS; CHLOROBENZES tS
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, B.
cliudio, H.F.I.
1977
Chroaatographlc Science
15:239-2ft«
-------
Heptane, 2,5-diBethyl-
Z216-30-C
C9-H20
US 128.25, BP 136 C
6317
Breath
EXPOSUBE ROOIB
ANALYTICAL
BETHOD
GC/BS
NDHBEB
OF CASES
28
RANGE
0.18-1.7 ng/1
...
BEAU
0.6 as/1
GESEBAL IHFOHHATIOH
Estimated fcon graph
Rigid protocol 14 days before and
daring study to •iniiize nuaber and
aaount of exogenous constituents.
AtDlTS; BBIATH; ALCOHOLS; CHLORINE
ORGANIC COMPOUNDS; CHLOBOBENZENES
REFERENCE
Krotoszynski, B.
Gabriel, G.
Claudlo, B.p. A.
1977
Journal of
chronatographic science
15:239-2*4
Heptyl alcohol (8 CI)
1-Heptanol (9 CI)
111-70-6
C7-H16-0
nw 116.2, up -311.6 c, SP 175.8 c, vp i «« Hg at ii2.» c
6378
Breath
EXPOSURE ROUTE
ANALYTICAL
flETHOD
HOMBE6
OF CASES
2.7-8 ng/1
ng/1
GENERAL INFORMATION
Estinated fron graph
Healthy 18-60 yr olds, nonsaokers.
Rigid protocol 14 days before and
during study to ainivize nuiber and
aioant of erogenous constituents.
AEOLTS; EBEATB; ALCOHOLS; CHLORINE
OBGASIC COBEOOSDS; CHLOBOBEHZEBES
DEFERENCE
Krotoszynski, B.
.Gabriel, G.
O'Neill, H.
Claudio, B.p. A.
1977
Journal of
Chroaatographic Science
15:239-244
Hcxane
110-51-3
C6-H1H
»» 86.17, BP 68.7 C, If 100
TISSDE
6379
Breath
6380
nrine
EXPOSURE ROUTE
Inhalation
ANALYTICAL
HETH00
SC/HS
GC
BDHBER
OF CASES
.
28
41
RANGE
2-10 ng/1
a)
-------
Hexane, 1-chloro-
?"11-10-5
C6-B13-C1
(IB 120.62, BP -9« C, BP 131 C
TISSUE
6381
Breath
EXPOSURE ROUTE
ANALYTICAL
BETBOD
sc/«s
SUNBER
OF CASES
28
E4NGE
0.55-3.5 ng/1
HE AN
1.4 ng/1
GENERAL IHFOBHATIOH
Estiaated frOB graph
Healthy 18-60 yr olds, nonsBOkets.
Rigid protocol 14 days before and
during study to BiniBize nuaber and
aaount of exogenous constituents.
JCOLTS; BREATH; 4KOHOI5; CHLORIKE
CFGASIC COBPOIJSDS; CHIOEOBEIZEHE5
. .. . .
BEFEREHCE
Krotoszynski, B.
Gabriel, 6.
O'Neill, H.
Claudio, fl.P.A.
1977
Journal of
chronatographic Science
t5:239-2««
Hexane, 2,3-di»ethyl-
589-914-1
C8-H18
KB 11H.23, BP 116 C, VP 10 •• Hg at 9.9 C
6362
Breath
EXPOSURE ROUTE
LYTICSl
ETHOD
-
KCWBM
OF CASES
29
SASSE
3.5-18 ng/1
_
HESS
6 ng/1
GENERAL INDORSATION
Estiaated froa graph
Healthy 18-6Q yr olds, noasBOkets.
Rigid protocol 14 days before and
during study to BiniBize nuaber and
IDOLTS; BBBATH! ilCOBOlS; CHIOMW
0 EG ASIC COaECONDS; CHLCROB INZED B5
BEFEREKCE
...
Krotoszynski, B.
Sabriel, s.
O'Mill. H.
Claudio, B.P.A.
1977
ChroBatographic science
N3
O
ntxane, 2,3,5-trinethyl-
1069-53-0
C9-B20
BB 128.25, (IP -127.8 C, BP 131.3U C
1 TISSUE
1
6383
Breath
EXPOSURE ROUTE
A.HALYTIC1L
(IETHOO
oc/ns
_
BOBBER
OF CASES,
28
EANGE
1.5-9.5 ng/1
.
BEAH
3.8 ng/1
__l
GEBER4L IKFOBBJTICN
Estimated froa graph
Sealthy 18-60 yr olds, noosiokers.
Rigid protocol 14 days before and
dariog study to ainiiize ouiber and
anonnt of exogenous constituents.
ADULTS; BEHTHJ MCOBOLS; CHLOBHI
OEGAMIC COBPODHDS; CHLOR08 ESZEKES
RErEEEHCE
Krotoszynski, B.
Sabriel, G.
O'Beill, B.
Claudio, B. P.A.
1977
Journal of
Chroaatographic Science
15:239-2«4
-------
Bexane, 3,4-dimethyl-
583-1(8-2
C8-H18
»» 11H.23, BP 117.72 C, VP 10 II Hg at 11.3 C
TISSUE
6381
Breath
EXPOSURE BOOTE
ANALYTICAL
SETHOD
GC/BS
BOBBER
OF CASES
28
RANGE
1.7-5.5 U
-------
Iodine
1553-56-2
t» 126.9015, BP 113.60 C, BP 185.21 c, VF (solid) 0.03 mm Hg at 0 C, 0.305 mm Hg at 25 C. 2.154 nm Hg at 50 C, 26.78 mm Hg at 90 C
(CONTINUED)
TISSUE
Hver
6389
Orine
tltine
EXPOSURE ROOTS
_
ANALYTICAL
HETHOD
HA
NOBEER
OF CASES
6
RANGE
applicable
0.089-0.711 ug/ml
MEAN | GENERAL INFORflATIOS
1
1
.12 mg/dl
Not given
mg/dl solution. Autopsy data
57 yr old, epileptic and alcoholic.
fcund dead in residence
ADOLTS; AUTOPSIES; BLOOD; LI7ER;
URINE; BEASOEEnEST BETHODS; IODIKE
Precision < 6*. niniium detectable
level 0.05 ug/«l
OEIBB; HESSOEEBEHT BETHODS ; IODINE
•g/dl solution. Autopsy data
57 yr old, epileptic and alcoholic.
found dead in residence
ADOLTS; AOTOPSIBS; BLOOD; LIVES;
OEIHE; HESSOBBHEFT BETHODS; IODISE
BEPERENCE
1981
Clinical Toxicology
18(7):807-811
Blotcky, A.J.
Duven, D.B.
Grauer, w.fl.
Back, E.P.
1971
Analytical Cneaistry
16(7) : 8 38-8 12
1981
Clinical Toxicology
18(7) : 807-811
ri(Jiun
139-88-5
tn 192.22, BP 2150 C, BP approximately 1500 C
TISSUE
6391
Hair
EXPOSURE ROOTS
ANALYTICAL
BETHOD
HA
son BEE
OF CASES
1
BASSE
.
3.0X10 (E-6J-17.0X10 (E-6)
g/cu cm
HEAN
Not given
GENERAL INF08HATION
3 cm segments of single hairs
Some samples belou detection limits
I8IDIOH; BAIB: FORENSIC MEDICINE;
BEASOREBENT BETHODS; AHTISCHT;
ARSENIC: BROIIINE; COPPER; GOLD;
LUTHAIIOB; SAHGANESE; HERCDBI;
BETALS; SELENIDB; SILVER; SODIOB;
SIBO»TIDB; ZI«C; MIIISTRIAL
REFERENCE
Dybczynski, R.
Boboli, K.
1976
Journal of
Radioanalytical
Chemistry 31:267-289
-------
Iron
7H39-89-6
Fe »
AtS 55.847, BP 1535 C (pure), 1000-1300 C (cast), 1500 C (wrought), 1300 C (steel), BP 3000 C, IP 1 KB Hg at 1767 c, 10 mm Hg at 2040 C
TISSUE
6392
Adrenal
gland
6393
Aorta
639U
Blood,
serum
6395
Blood,
whole
EXPOSQRE ROUTE
ANALYTICAL
BETHOD
ES
ES
X-Ray
Spectronetry
NOBBEB
OF CASES
7
7
a) 6
b) 6
27
BANGE
Not given
Hot given
a) 190-330 ug/dl
b) 54-175 ug/dl
Hot given
BEAN
230 »or- 71 ppm dry
vt
110 «-or- 51 ppm dry
wt
a) 259 ug/dl
b) 116 ug/dl
J34 ppn
GEIEBAL INFOBBATION
Horaal tissue
Autopsies
Japan
TONGOE; ZISCONIOB; ELEBENTS: JAPAN;
ACOITS; AtFTOPSIES; ADBENAL GLANDS:
AOBTA; BONES; HEABT; INTESTINES:
KIDNEYS; LIVER; LONGS; LTBPB NODES;
SPLEEN; PANCREAS; STOBACH; THYEOID
GLANDS; TBACHEA; ALOBIHOH; BARIOB;
CADBIOB; CAICIOB; CHROBIOH; COBALT:
CCPPEB; IROH; LEAD; BAGNESIOB;
BANGANESE; BETALS; BOLYBDEBOB;
NICKEL; FHOSPHORDS; POTASSIIJB;
SILICON; SILVER; SODIOB; S1BOHTIOB:
1I»J TITAtllOB; ViNADIOB; ZINC;
EIOACCOBtJLATION; HEALTH HAZARDS;
OCCDPATIONAI HAZABDS
Normal tissue
Autopsies
Japan
TONGOE; ZIBCONIOfl; ELEBENTS: JAPAN;
A DOLTS; ADTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEABT; INTESTINES;
KIDNEYS; LIVER; LONGS; LYMPH NODES;
SPIEEN; PABCEEAS; STOBACH; TBYHCIO
GLANDS; TRACHEA; ALOBINOB; BABItJB;
CADBIOB; CALCIOfl; CHROKIOH; COBALT;
COPPBB; IBO»; LEJD: BAGSESI09;
BANGANESE; BETALS: BOLYBDEHOB;
NICKEL: PBOSPHOBOS; POTASSIOB:
SILICON; SILVER; SODIOB; STRONTIOB;
TIS; TITASIOB: VASADI08; ZIHC;
BIOACCOBOLATION; HEALTH HAZAfiDS:
OCCOPATIONAL HAZARDS
a) Subjects with increased Fe stores
b) Subjects with normal Fe stores
Serum levels did not reflect tissue
levels
Liver biopsy best diagnostic method
Fanily with precirrhotic
CBELATING AGENT; GENETIC STODIES;
CASE HISTORIES; LIVER DISEASES; HETAL
POISONING; BLOOD SEROB; LIVEE; OHIBE;
I EON
Precision 7K
ELOOD; BEASOREBENT BETHODS; COPPER:
IROS; BETALS; RDEIDIOB; SEI2HI09;
ZINC
.
REFERENCE
TeraoKa, H.
1931
Archives of
Environmental Health
36(»):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36 (») 1155-165
Feller, E.R.
Pont, A.
Hands, J.R.
Carter, E.A.
Foster, G.
Kourides, I. A.
Isselbacher, K.J.
Nev England Journal of
Medicine
296(25) :1H22-1«26
Bearse, B.C.
Close, D.A.
Balanify, J.J.
Dmbarger, C.J.
197H
Analytical chemistry
... ._ i
(NEXT PAUE)
-------
Iron
7H39-89-6
Fe
At» 55.847,
HP 1535 C (pure), 1000-1300 c (cast), 1500 C (wrought) , 1300 C (steel) , BP 3000 C, IP 1 mm Hg at 1787 C , 10 mm Hg at 2000 C
(CONTIHUED)
TISSO!
6396
Bone
6397
Hair
6398
Hair
6399
Hair
EXPOS0BE BOOTH
ANALYTICAL
BETHOD
ES
NA
NA
AtS
..
VUHBEB
OF CASES
5
60
3
--
BASSE
Not given
35-100 ug/g
a) 19-260 ppm
t>) 13-262 ppm
c) 35-166 ppn
d) 40-178 ppi
a) Hot give
b) Hot give
c) Not give
d) Hot give
e) Hot give
f) Hot given
BEAN
390 tor- 160 ppm dry
wt
Not given
a) 102 +or- 50 ppin
b) 110 +or- 54 ppa
c) 91 +or- 40 ppm
d) 99 +or- 40 ppm
a) 19.0 ug/g
b) 9.8 ug/g
c) 19.0 ug/g
d) 9.6 ug/g
e) 13.8 ug/g
f ) 11.4 ug/g
GENERAL IHFOBHATIOH
Normal tissue
Autopsies
Japan
TOHGOE; ZIBCOKina; ELBBENTS; JAP»»;
ADOLTS; AUTOPSIES; ADKESAI. GLANDS;
AORTA; BONES; HEART; IKTESIINES;
KIDHEYS; LIVEB: LONGS; LTBPH NODES:
SPLEEN; PANCREAS; STOBACH; THYROID
GLAHDS; TBACBEi; SLUBISOB; BABIOK;
CAMION; CiLCIUH; CHEOBinil; COBALT;
COPPER; IBON; LEAD; B AGNES I OH;
BANGtHESE; HBTALS; BOLTBDE«l)B;
HICKEL; FHOSPHOBOS: POTASSIOB;
SILICON; SIIVEB: SODIOfl; SIBOBTIOB;
TIN; TITANIOB; V1NADIBB; ZINC;
EIOACCOBOHTIOH-, HEALTH HAISBDS;
OCCnPATIONAI HAZARDS
Range of fleans, estimated from graph
Aswan, El Kharga, Assait, Cairo, and
Alexandria, Egypt
EGYPT; BUB; NAILS; INTIBONY;
CADBIOB; CESIOB; CHROBIOB; COBALT;
I ROB; aiHGANESE; METALS; HOLYBDEHOB ;
scmBinii; siiEsmaj SIUSBJ MUGSTJH;
ZINC; DRIDKIBG HATEE; POPULATION
EXPOSURE; SOILS; URBAN AREAS
a) 12 cm length, % samples
b) Poot section, 18 samples
c) Distal section, 18 samples
d) students in a) , 25 samples
Betropolitan Bombay, India
INDIA; ADOLESCEHTS; ADULTS; BAIR;
ABTIBONT; ARSENIC; BROBUE; CADBIUB;
CEIOSINE; CBROKIUB; COBALT: COPPER;
GOLD; IODINE; IRON; LABTHAHOB;
BABGANESE; POTASSIDB; SCAIDIOR;
SELENIUB; SILVER; SOOIOB; ZINC; AIR
EOLLOTIOB; BIOiCCOBOHIIOIl; POSSIL
FUELED POUER PLANTS; INDUSTRIAL
AEEkS; IBDnSTPIAL ITKOSPBUBES;
INDUSTRIAL EBISSIOHS; IBDOSTBIAL
POLLUTION; POPULITIOB EXPOSURE; URBAN
AREAS; INDUSTRIAL CHEBICALS
a) Subject 1, unwashed hair
b) Subject 1, after 12 successive
c) Subject 2, unwashed hair
d) Subject 2, after 12 successive
e) Subject 3, unwashed hair
f) Subject 3, after 12 successive
washes in sodiua laucyl sulfate
a), c) , e) 6-10 determinations, each
subject. -Data also foe other
.procedures and washing agents, for
ether procedures and washing agents.
HUE; COflPABATIYE EVALOATIOBS;
CADBIOB; COPPED; IBON; BANGABESE;
zinc
EEEEBENCE
Teraoka, B.
1981
Archives of
36 (»): 155-165
Kasperelc, K.
lYengar, G.v.
Peinendegen, L.E.
Hashish, s.
Bahfouz, «.
1982
Science of the Total
Environment 22:119-168
Bhat, K.B.
Arunachalam, J.
Yegnasubramanian, S.
Gangadharan, S.
1982
Science of the Total
Environment 22:169-178
Salmela, S.
Vuori, E.
Kilpio, J*0*
1981
Analytica chimica Acta
125: 131—1 37
(BEI1 PAGE)
-------
Icon
7039-89-6
Fe
It* 55.847, BP 1535 C (pure) , 1000-1300 C (cast), 1500 C (wrought), 1300 C (steel), BP 3000 C, If 1 » Hg at 1787 C , 10 H Bg at 20KO C
(CONTINUED)
TISSUE
6«00
Heart
6H01
Intestine
6U02
Kidney
EXPOSURE ROD IE
ANALYTICAL
METHOD
ES
ES
ES
N OM BEE
OF CASES
a) 6
b) 2
O 3
d) 1
e) 1
10
a) 8
b) 2
c) 3
d) 1
e) 1
RANGE
a) Mot given
b) 180-290 pp»
c) 180-650 pp«
d) Not applicable
e) Not applicable
Dry lit
Not given
a) Not given
b) 170-340 pp«
c) 160-110 pp»
d) Hot applicable
e) Hot applicable
Dry wt
BEAN
a) 240 + or- 38 ppm
b) 235 pp>
c) 357 ppn
d) 180 pp»
e) 200 pp»
Dry wt
170 +or- 75 ppm dry
»t
a) 320 »or- 1 10 ppn
b) 255 pp»
c| 293 ppm
d) 690 ppa
e) 390 ppn
Dry wt
GENERAL INFORHATIOH
a) Normal healthy men
by chroniam plating workers
c) chronate refining workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
TCNGOB; ZIBCONIOB; ELEHEHTS; JtPtN;
ADULTS; JOTOPSIES; »DB E»»L GLANDS;
iOBTA; BONES; HEART; INTESTINES;
KIDNEYS; LIVER; LUNGS; LTHPB NODES;
SPIEEN; PISC8EAS; STOBICB; TBTBOID
GLANDS; TRACHEA; ALOBIHOB; BAHIOB;
CADBIOn; CALCIOI1; CHBOHIDH; COBALT;
CCPPER; IHOH; LEAD; HAGHESIDB;
MANGANESE; METALS; HOLYBDENOX;
NICKEL; EHOSPHOROS; POTASS lOfl;
SILICON; SILVEE; SOOIOB; STSONTIDfl;
TIN; TITANIOB: ViBADIUH; ZINC;
BIOACCONHLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
. - _. ..
NorBal tissue
Autopsies
Japan
TCNGUE; ZIBCOHIOP; ELEMENTS; J-IPAN ;
ADULTS; AUTOPSIES; ADB1NAL GLANDS;
AOETA; BONES; BEART: INTESTINES;
KIDNEYS; LIVES; 1DNGS; LTBEH NODES;
SPLEEH; PAKCBEJS; STOdACB; THrEOtD
GLANDS; TKACHEA; ALDnlNUII; BARIOH;
CAOBIUB; CALCIDD; CBRCBIUB; COBALT;
CCFPER: IRON; LEAD; HAGNESIOH;
PANGANESE; 9ETALS; BOLYBDENUB;
NICKEL: PHOSPHORUS: POTASSIDB;
SILICON; SILVEB; SODIUB; SIRCNTIUB;
IIS; TITANIUB; VANADIUB; ZINC;
BIOACCDBDLATION; HEALTH HAZARDS;
OCCUPATIONAL BAZABDS
a) Horaal healthy icn
b) chroain* plating workers
c) chroiate refining workers
d) Airplane painter
e) Stone Mason
Autopsies
Japan
TCNGUE; ZIRCONIUB; ELEHENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL SLANDS;
AORTA: BONBS; HEJRT: INTESTINES;
KIDNEYS; LIVER; LUNGS; LYKPH NODES;
SPLEEN; PANCREAS; STOHACH; THYROID
GLANDS; TRACHEA; ALUBINUB: BARIUB;
CADBIOn; CAICIUB; CBROBIDH; COBALT;
CCPPER; IRON; LEAD; BAGNESIUB;
BANGANESE; BETALS; BOLYBDEBUH;
NICKEL: PHOSPHORUS: POTASSIOB;
SILICON; SILVER: SODIUB; S1RONTIUH;
TIN; TITAHIOfl; VANADIOB; ZINC;
BIOACCUBULATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36 (»): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(«):155-165
Teraoka, H.
1981
Archives of
36(11) :155-165
N5
Ul
(NEXT PAGE)
-------
lion
7H39-89-6
Fe
AtB 55.847, HP 1535 C (pure), 1000-1300 C (cast), 1500 C (wrought) , 1300 C (steel), BP 3000 C. VP 1 u Hg at 1787 c, 10 BB Hg at 2000 C
(COBTISUED)
6U03
Liver
60 OH
Liver
6» 05
Liver
5SOE
5
3r
r
EXPOSOBE BOOTE
AKALYTICAL
METHOD
ES
MS
NA
NOB BEE
OF CASES
a) 9
b) 2
c) 3
d) 1
e) 1
a) 5
b) 6
30
a INGE
a) Not given
b) 350-1100 ppn
d) Not applicable
e) Hot applicable
Dry wt
..
a) 800-2500 ug/100 mg
Dry wt
_
70-210 ug/g
BEAN | GENERAL INFORMATION
a) 1100 +or- 970 ppra
b) 725 ppm
I) 1800 ppm
e) 660 ppm
Dry wt
a) 1U50 ug/IQQ aj
Dry wt
Not given
a) Nornal healthy Ben
b) ChroBiui plating workers
d) airplane painter
e) Stone Bason
ADtopsies
Japan
TCNGOE; ZIECCSIOB; ELEHEKTS; JAPAS;
tDDLTS; IOTOPSIES; ADRENAL GLANDS;
AOETA: BORIS; BEAST; IHTES1INES;
KIDNEYS; IIVEE: LDNGS; LTBPH NODES;
SPLEEN; PANCBEAS; STCHACH; TBYEOID
GLAKDS; TEACHES; ALOHINnK; BABIOB;
CADBIUfl; CAICIOS: CHBOMIDI! ; COBALT;
CCPPEE; IEON; LEAD; nAGNESIUH;
KANGANESE; HETJLS; HOL YBDENHK ;
• ICItIL; FBOSPHOBOS; POTASS 10B:
SILICON; SIL7EE; SODIOB; SIEOBTIDn;
TIN; TITANIDH; JANADIUB; ZINC;
BIOACCOirailTION; HEALTB HAZAEDS;
OCCOPATIONAL BAZAEDS
a) Subjects vith increased Fe stores
Liver biopsy best diagnostic Bethod.
FaBily with precirrhotic
CBE1ATIBG AGINT; GENETIC STODIES;
CASE HISTOEIES; LITEE DISEASES; BETAL
POISOBING; BLOOD SEPOB; LIVES; OEINE;
icon
Category 2 as proposed by
International Workshop on Bonitoring
Environaental Baterials and speciaen
Bonitored for "norBal" levels)
Autopsies, Baltimore, BD,
flinneapolis, BH, and Seattle, «A
BABILAHD; BINNESOTA; BASHINGTOH;
AOTOPSIES; IIVEEJ BEAS0EEBEBT
BEtRODS; ALOI1INOB; ABTinOKY; ABSEBIC;
EAEIOB; CADBIOB; CHEOBIOB; COBALT;
CCPPEB; FLOOEINE; IEOB ; LEAD;
BiHGHKESE; BEPCDEI; HOLTBDS80B ;
NICKEL; ROBIDIUH; SELEBIOB; SHVEE ;
STEONTIOH; TBALLIOB; TIN; VAHADIOfl;
ZIKC; POPDLATIOB ET.POSOBB
BEFEEENCE
Terdoka, B.
1981
Environmental Bealth
36(4): 155-165
Feller. E.e.
Pont, A>
Vands, J.E.
Carter, E.A.
Foster, G.
Kourides, !•&.
Isselbacher, K.J.
1977
Bedicine
296(25) : H22-1U26
Barrison, S.H.
Zeisler, E.
Rise, S.A.
198 1
EPA 600/S1-81-025, 6
pp.
(NEXT PAGE)
-------
Iron
7(39-89-6
Fe
AtH 55.817,
DP 1535 c (purs), 1000-1300 C (cast), 1500 C (wrought), 1300 C (steel), BP 3000 C, VP 1 i! ag at 1787 C, 10 •• Hg at 2010 C
(CONTINUED)
TISSUE
fit 06
lung
6407
Long
6008
Lymph
node
6109
Hail
EXPOSURE ROUTE
Inhalation
ANALYTICAL
HETHOD
ES
ES
NA
SOUSES
OF CASES
a) 12
b| 2
c) 3
d) 1
e) 1
16
a) 3
b) 1
c) 3
d) 1
e) 1
66
BANGS
a) Hot given
b) 360-2900 ppi
c) 920-4200 ppm
d) Hot applicable
e) Not applicable
Dry wt
..
a) 5.43-11. 21X dry »t
c) 2.17-6.06* dry wt
d) 1.47-3. 25S dry ut
a) Not given
b) Not applicable
c) 1200-1900 ppo
d) Hot applicable
e) Not applicable
Dry wt
120-1080 ug/g
MEAN
a) 740 +or- 180 ppm
b) 1180 ppm
c) 2306 ppn
d) 460 ppa
e) 1300 ppa
Dry wt
a) Not given
c) Not given
dj Kot given
a) 1800 +or- 640 ppm
b) 800 ppm
c) 1600 ppa
d) 9«0 ppm
e) 600 ppm
Dry wt
Not given
GE1HB&L MFOBIUTION
a) Horaal healthy men
b) Chroiiui plating workers
c) Chroiate refining workers
d) Airplane painter
e) Stone nason
Autopsies
Japan
TCNGOE; ZIBCONIOfl; ELEflEHTS; JAPAN;
ADULTS; AUTOPSIES; ACBENAL GLANDS;
10STA; BONES; HEIKT; IHTES1IHES;
KIDHlyS; LIVES; LOHSS; LlgPO KOBBS;
SPLEEN; PANCREAS; STOB1CH; THTBOID
GLANDS; TRACHEA; ALOHINOK; BABIOn;
CADfllOB; CALCIDB; CHGOaiail; COBALT;
CCPPBB; 1808; IE1C; BiGHESiaH;
HANGANESE; HETALS; DDL YBDENDH;
NICKEL; PHOSPHOEOS; POTASSJOB:
SILICON: SILVER; SODinB; STRCNTIOB;
TIB; TITABI09; »»B4DIO»; ZINC;
EIOACcaaOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZABDS
a) conplicated pneuioconiosis, large
b) Coaplicated pneaBOconiosis,
lesions
Exposure levels not reported.
Cock Biners
LONGS; IRON; HETALS ; HIHINC:
OCCOPJTIONAt HAZARDS
a) Noraal healthy ven
b) ChrofliUB plating workers
c) chroaate refining workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
TCHGtJE; ZIRCONIOB; ELEBENTS; JAPAN;
SCOLTS; AOTOPSIES; ADRENAL GLANDS;
AORTA; BONES: HEAET; INTESTINES;
KIDNETS: LIVER; LONGS; LYHEB NODES;
SH.ZEN; PANCSEAS; STOBACH; THYROID
GLANDS; TRACHEA; ALUMINUM; BARIDB;
CAoniun; cAicioB; CHROBIDB; COBALT;
CCPPEB; IROH; LEAD; HAGNESIUB;
CANGASESE; BETALS; BOLIBDEDDIt;
NICKEL; PHOSPHORUS; POTASSIOH:
SILICON; SILVER; SODIOB; SIRONTIUB:
TIN; TITANIOB: VABIDIUB; ZINC;
BIOACCOBOLATIOH; HEALTH HA2ABDS;
CCCOPATIOHAL HAZARDS
Range of Beans, estimated froB graph
Aswan, El Kharga, Assuit, Cairo, and
Alexandria, Egypt
EGYPT; HAIR; NAILS; ANTIBONY;
CADHIDB: CESIOB; CHROBI0B; CCBALT:
IBON; BANGANESE; BETALS; BOLYBDENUB:
SCJUDIOH; SILEIIIOB; SILTBS; TOSGSTBK;
ZINC; DEINF.ING HATER; POPULATION
EIPOSDBE; SOILS; DEBAS AEEilS
REPERENCE
Teraoka, H.
1981
Archives of
Environtental liealth
36 (»): 155-165
Guest, L.
1981
Analyst 106-.663-675
Teraoka, H.
1981
Archives of
Environaental Health
36(1) : 155-165
Kasperek, K.
lye&gar, G.v.
Feinendegen, L.E.
Hashish, S.
flahfouz, B.
1982
Science of the Total
Environnent 22:149-168
(HEX! PAGE)
-------
Iron
7*139-89-6
re
ttf 55.8t7, HP 1535 C (pure), 1000-1300 C (cast), 1500 C (wrought), 1300 C (steel), BP 3000 c, VP 1 nm Hg at 1737 C, 10 BB Hg at 20HQ C
(CONTINUED)
TISSDE
6110
Pancreas
Spleen
6412
Stoiach
EXPOSURE ROTJTE
1
ANALYTICAL
BBTHOD
ES
ES
BOBBER
OF CASES
5
W 2
c) 3
a> 1
e) 1
10
EA8GE
Hot given
b) 1200-6800 ppm
c) 660-10000 ppm
d) Hot applicable
e) Not applicable
Dry »t
Sot given
BEAN
160 tor- 53 ppm dry
»t
b) 4000 ppm
c) 4353 ppm
d) 4800 pprn
e) 1900 ppm
Dry wt
170 +or- 75 ppm dry
vt
GEBEBAL ISFORBATICN
Normal tissue
Autopsies
Japan
TCSGOE; ZIRCONIOB; ELEHENTS: JAPAN;
AUDITS; JDTOPSIES; ADRENAL GLANDS;
AORTA: BONIS: HEART; INTESTINES:
KIDNET.S; LI?EE; LONGS; LIBPH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLANDS; TRACBEA; ALUBINUB; BARIUB;
CADBIOB; CALCIOB; CBROBIDB ; COBALT:
COPPER; IRON; LEAD; BAGNESIOB;
SANGAHESf; BETALS; HOLTBDENRB:
NICKEL; PHOSPHOROS; POTASSIDS;
SILICON; SILVER; SODIOB; ST80NTITO;
TIN; TITANIOH; V4NAPIOB; ZINC;
BIOACCOHDLATION; HEALTB BAZARDS;
OCCDPATIONAL HAZARDS
b) chromium plating workers
c) chromate refining workers
9) Airplane painter
•e) stone mason
Autopsies
Japan
TCNGDE; ZIRCONIUB; ELEBENTS: JAPAN;
ADULTS; ADTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HE JET; INTESTINES;
KIDNETS; LIVER; LUNGS; LIBER NODES;
SELEEN; PANCREAS; STOBACH; THTROID
GLANDS; TRACHEA; 4LOBINUB; BARIOB;
CADBIUB; CAICIDB; CBROHIDB; COBALT;
CCPPEB; IBON; LEAD; BAGNESIUB;
BAHCANESE; BETALS; BOLTBDEfOB;
NICKEL; EHOSPHORDS; POTASSIOB;
SILICON; SILVER; SODIUB; STRONTIDB;
TIN; TITAHIHH; VANADIDB; ZINC;
BIOACCUBOLATION; HEALTH HAZARDS;
CCCDflTIONAL BAZARDS
Normal tissue
Autopsies
TONGOE; ZIRCONIDB; ELEHEDTS: JAPAN;
ADOT1S; AUTOPSIES; ADRENAL GLIHOS;
AORTA: BONIS: HEART; INTESTINES;
KIDNEIS; LIVER: LONGS; LYBPH NODES;
SPLEEN; PANCREAS; STOBACH; THTROID
GLANDS; TBACBEA; ALDBINUB; BARIUB:
CADalOB; CALCIOfl; CBBOBIDB; COBALT;
COPPER; IRON: LEAD; BAGHESIUB;
B1NGANESI; B1TALS; BOLIBDENUB;
NICKEL; PHOSPHORUS; POTASSIOB;
SILICON; SILVER; SODIUB; STRONTIOH:
TIN; TITANIOB; TANADITJB; ZINC;
BIOACCOBOLATIOS; HEALTH HAZARDS;
OCCUPATIONAL BAZARDS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
1981
Archives of
Environmental Health
36(4): 155-165
Teraoka, H.
1981
Archives of
36(4) : 155-165
N>
00
(NEXT PAGE)
-------
Iron
7H39-89-6
Fe
Atw 55.847,
HP 1535 c (pure), 1000-1300 C (cast). 1500 C (Draught). 1300 C (steel), BP 3000 C, ff 1 » Hg at 1787 C, 10 u Hg at 2010 C
(CONTINUED)
TISSUE
6113
Thyroid
gland
611U
Tongue
6015
Trachea
2IPOSUBE BOUTE
AHALTTICAL
HETHOD
ES
ES
ES
HDD BED
OF CASES
II
2
2
BAN
Mot given
Sot given
Not given
90 +or- 18 ppa dry wt
95 +or- 3.5 ppn dry
wt
100 +or- 55 pp« dry
GENERAL IHFORBATION
Normal tissue
Autopsies
Japan
TONGUE; ZIBCCN1UB; ELEBEHTS; JAPAD;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BODES; HEART; INTESTINES;
KIDNEYS; LI7EB; LONGS; LTBPB BODES;
SPLEEN; PANCBEAS; STOB1CH; THYBOID
GLANDS; TBSCHEA; ALDBIHOB; B1HIOB;
CADBIOB; CALCIOB; CHBOHIHB; COBilT;
CCPPEB; IROI; I.EID-, BAGHeSIOB;
BJNGARESE; BETALS; 80LTBDEIDB:
•ICKEL; EHOSPHOBOS; POTASSIOn;
SIIICOB; SIITEE: SODIDB; S1BOHTIOB;
Tin; TITAKIOt!; rilMDIDR; SI»C;
EIOACCDBDLAIION; HEALTH RA2AEDS;
OCCUPATIONAL HAZABDS
Horial tissue
Anto^sies
Japan
TOXGDE; ZIBCOHIDB; ELEBBNTS; JAPAN;
ADOI.TS; AUTOPSIES; »DEE»Al GlAUDSj
AORTA; BODES; HEAST; INTESTINES;
KIDSF.IS; LI1EB; LmiGS; 1TSPH HOOTS;
SPIEEg; PlHCBEiS; STOHACH; TBrfiOID
GLANDS; TRACHEA: ALOBIHDB; BIRIOB;
CADHIOH; CAICIOB; CHBOBlnS; COBALT;
COPPER; IBOD; LEAD; BAGNESIOfl;
BANGANESE; BETALS; BOLYBDENOB;
NICKEL; PHOSPHORDS; POTASSIOB;
SIIICOD; SILVEB; SODIOB; STBODTIOB;
TID; TITABIOB: TAHADIOB; ZIDC;
BIOACCOBDLATIOD; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
Noraal tissue
Autopsies
Japan
TONGUE; ZIRCCHIUfl; ELEHEDTS; JAPAN;
ACOtTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BOSES; HEART; IHTISTHES;
KIDNETS; LIVER: LONGS; LTHEH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLANDS; TRACHEA; ALOBI NUB; BARIDB;
CADBIDB; CAiCIOB; CHBOSlnH; COBALT;
COPPER; IROD; LEAD; BAGNESIOB;
BiNGANESE; BETALS; BOLYBDENDB;
BICfEL; EHOSPHOROS; POTASS10H;
SILICON; SIL»EB; SODIBH; SIRODTIOB;
TIN; TITAKIOH; fADADIOB; ZINC;
BIOACCDHOLATIOB; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
(NEXT PAGE)
Teraoka, H.
1981
Archives of
Environmental Health
36(1): 155-165
Teraoka, R.
1981
Archives of
Environmental Health
3«(H|: 155-165
Tecaoka, H.
1981
Archives of
Environmental Health
36(4):155-165
-------
Iron
7H39-89-6
Fe
At» 55 847 HP 1535 C (pure), 1000-1300 C (cast), 1500 C (wrought), 1300 C (steel), BP 3000 C, VP 1 mm Hg at 1787 c , 1C n« Hg at 20140 C
(CONTINUED)
TISSCS
6»16
Urine
EXPOSURE BOOTE
Injection
imiYTICkL
BETHOD
SDBBEE
OF CASES
a) 6
n) 6
BASSE
a) 536-21,047 ug/2» hr
b) 272-888 ug/21 hr
BEAN
a) 7063 ug/2» hr
b) 696 ug/2» hr
GENEBAL IBFORBATICH
a) Subjects with increased Pe stores
b) Subjects with norKl Fe stores
IB
Chelatable Fe extraction did not
reflect tissue levels
liver biopsy best diagnostic lethod.
Family with precirrhotic
hecochroaatosis
CHELATING AGENT; GENETIC SIUDIES;
CASE HISTORIES; 1I7EB DISEASES; BETA!
FOISO»I»G; ELOOD SEBOH; LUEB; ORI1IE;
ICON
BEFEEENCE 1
Feller, E.B.
Pont, I.
Carter, E.A.
Foster, G.
Kourides, I. A.
Isselbacher, K.3.
1977
New England Journal of
fledicine
296(25) :1«22-1»26
IsobtttYl alcohol (8 CI)
1-Propanol, 2-«ethyl- (9 CI)
78-83-1
C1-H10-0
fB 7U.12, BP 107.90 C, VP 10 nil Hg at 21.7 C
TISSOE
6U17
Breath
EXPOS0BE RODTE
SNAIYTICAL
(IETHOO
GC/BS
HOUBEE
OF CASES
28
BADGE
0. 18-1. 5 ng/1
flEAH
0.5 ng/1
GE8EEAL INFOBHATIOH
Estiaated fron graph
Healthy 18-60 yr olds, nonsHokers.
Rigid protocol 14 days before and
during study to linilize nuiber and
amount of exogenous constituents.
AtUlTS; BREiTHj ALCOHOLS; CBIORIUF.
ORGAHIC COBPODHDS; CH10BOB ENZESES
. _..
REFBRESCE
Krotoszyoski, B.
Gabriel, G.
O'Neill, B.
Claudio, a. p. A.
1977
Journal of
Cbroaatographic Science
15:239-2»1
u>
o
Isooctyl alcohol (8 CI)
Isooctanol (9 CI)
2E952-21-6
C8-H18-0
US 130.22
TISSOE
6118
Breath
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC/BS
NOBBER
OF CASES
28
BADGE
1.2-6.8 ng/1
BEAN
3 ng/1
GEBEBAL I8FOBHATIOI
Estimated fro> graph
Rigid protocol 14 Says before and
aaount of exogenous constituents.
ACOLTS; BREATH; ALCOHOLS; CHLOKIHE
ORGAHIC COHPOOBDS; CHLOBOB ESZEBES
BEFEBESCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Clauaio. n.P.A.
1977
Journal of
Chroiatographic science
15:239-2141
-------
Isoprene (8 CI)
1,3-Butadiene, 2-aethyl- (9 CI)
78-79-5
C5-H8
BW 68.11, BP -146.7 C, BP 31 C, VP 400 aa Hg at 15.« C
TISSUE
64 1 9
Breath
EXPOSURE SOOTS
ABJirTICAL | SimBEli
METHOD
OF OSES
SiSSE
flEJ»
GEBEBA1 IHFORMTICS
roa grap
Wealthy 18-60 yr olds, nonsaokers.
Rigid protocol 14 days before aod
during study to Riniaize nuaber and
aaount of exogenous constituents.
•tOLTS; BREATH; AICOHOLS; CHLORINE
ORGANIC COHPOOSDS; CHLOBOB HHZEN ES
BEFERESCE
Gabriel, G.
O'Neill, B.
Claudio, K.P.A.
1977
Journal of
Chroiatographic Science
15:239-2H«
Isopcopyl alcohol (8 CI)
2-Propanol (9 CI)
67-63-0
C3-H8-0
B« 60.09, HP -88.5 to -89.5 C,BP 80.3 C, VP 10 HI Hg at 2.D C
TISSUE
6U20
Breath
EXPOS0BP ROOTE
*N»LYTIC»l
1ETHOD
GC/HS
HUHBEB
OF C»SES
28
BANGS
0. 18-7 ng/1
HE ill
1 ng/1
GEHEBiL INFOBHiTIOH
Estinated Ccoi graph
Healthy 18-€0 yr olds, nonsaokets.
Rigid protocol If days before and
during study to Minimize nunber and
aaount of exogenous constituents.
JCOT.TS; BREJTH; AlCOHOIS; CH10RISE
CBGHIIC COBPOdDDS; CH10SOBE8ZIBES
BEFEBEHCB
Krotoszynski, B.
Gabriel, G.
O'Heill, H.
Claudio, a. P. S.
1977
Journal of
Chroaatographic science
15:239-211)
anthaiius
139-91-0
a
tH 138.906, HP 920 C, BP 345« C, VP 3230 an Hg at «00 C, 3420 BB Hg at 760 C
TISSDE
61(21
Hair
EXPOSURE BOUTE
_
ISAtYTICAL
METHOD
Hi
HUBBER
OF CiSES
II
EANGE
0. 14X10 (E-6) -0.27X10 (E-6)
g/ca cm
GESERkL IHFOBntTIOD
Sot given
(BE.TT PAGE)
3 ca segnents of single hairs
Soae saaples below detection liaits
IRIDIUB; HAIR; FORENSIC BEDICINE;
BEASUREHENT HETHODS; AHTIBCNY;
ARSBHIC; BROBIBE; COPPER; GOLD;
LABTHANUH; BANGABESE: BERCORY;
BETA1S; SE1EBIUB; SILVER; SODIUB;
STROKTIUB; ZINC; INDUSTRIAL
ATMOSPHERES
Dybczynski, fi.
Boboli, K.
1976
Journal of
Radioanalytical
Chemistry 31:267-289
-------
lacthanua
7039-91-0
la
AtB 138.906, HP 920 C, SP 3454 C, VP 3230
Hg at 100 C, 3420 «i Hq at 760 C
(CONTINUED)
TISSUE
6922
Hair
1 _
EXPOSURE ROUTE
ANALYTICAL
BETHOD
NA
NOHBEB
OF CASES
BANGE
a) 0.003-0.22 pp«
b) 0.01-0.18 ppl
c) 0.01-0. 13 pp«
b)
c>
a; 0.05 +or- 0.03 ppm
b) 0.06 tor- 0.06 ppm
"» 0.04 +or- 0.04 ppm
GENERAL INFORMATION
a) 12 cm length, 98 sanples
b) Hoot section, 18 saiples
c) Distal section, 18 saaples
Metropolitan Boabay, India
INDIA; ADOLESCENTS; ADOLTS: HAIR;
AITIHONY; ARSENIC; BROHINE; CADBIUB;
CBLORINE; CHBOBItJH: COBALT; COPPER;
GC1D; IODINE; IRON; LANTHANUH;
BANGANESE; POTASSIOH; SCANOIOH;
SELENIUn; SILTEB; SODIOB; line; »IB
FC1LOTIOH; EIOACCOBDLATION; FOSSIL
FUELED POKER PLANTS; INDOSIRIAL
AfiEAS; IHDOSTEIAL iTBOSPHE5ES;
ISDOSTBUL MISSIONS; INDOSTRIll
POLLOTION; POPOLATION EIPOSOBE; OB BAN
AREAS; INDUSTRIAL CHEHICALS
REFERENCE
Bhat, K.R.
Aracachalai, J.
Tegnasubcananian, S.
Gangadharan, S.
1982
Science of the Total
EDTironient 22:169-178
lead
7439-92-1
Ft
AtB 207.2,
BP 327.4 C, BP 1740 C, TP 1.77 nil Hg at 1000 C,
Hg at 970 C, 10 an Hg at 1160 C
6423
Adrenal
gland
6424
Aocta
EXPOSURE flOOTE
ANALYTICAL
HETHOD
ES
ES
NtMBEB
OF CASES
7
7
RANGE
Not given
Not given
HE AS
2.2 +or- 1.7 ppm dry
vt
3.3 »or- 2.1 pp« dry
Ht
(HEX! PAGE)
GENERAL INFORMATION
Nocaal tissue
Autopsies
Japan
JAPAN; ADULTS; tOTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; BEAUT;
INTESTINES; KIDNEYS; LIVER; LUNGS;
ITBPB NODES; PANCREAS; SPLEEN;
STOSICH; TB1KOIO GllSOS; TBACHEI;
ALOBINtlB: BABIUH: CADBIRB; CALCIUI;
CESOHIOH; COBALT; COPPEB: IRON; LEAD:
lUGNESIOB; (UNGAHZSE; HSTAIS;
lOLYBDENUn; NICKEt: PHOSPRORDS;
POTASSIOfl; SILICON; SILTEB; SODIOB;
STBONTIOB; TIN; TITABIOB; VANADIOB;
ZINC; BIOACCDIIOLATION; BEALTB
BAZ1BDS; OCCDPATIOSA1 BAIABDS;
TONGDE; ZIRCONIUB; ELEBESTS
nocial tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BE1RT;
INTESTINES; KIDNEYS; LITER; LUNGS;
LIBPB NODES: PASCBEAS; SPLEEN;
STOBACH; TBYBOID GLANDS; TFACBEA;
ALUBINOB; BABIUB; CADBIUB; CALCIOB;
CBKOHHJH; COBALT: COPPER; ISOI; LEAD;
BAGNESIOB; BANGASESE; BETALS;
«ClYBDE»Da; NICKEL; PHOSPBCBDS;
PCTASSIOH; SILICON; SILTEB; SODIOH;
S1BOKTIUB; Til; TITANIUB; TAHADIUB;
ZI1C; BIOACCOBUL41ION; BEALTB
BAZABDS; OCCUPATIONAL BAZABDS;
TONGUE; ZIBCONIUB; ELEMENTS
Teraoka. B.
1981
Archives of
Environiental Health
36(4): 155-165
OJ
N3
Teraoka, H.
1981
Archives of
EnvironBental Health
36 («): 155-165
-------
lead
7139-92-1
Ft
At« 207.2,
IIP 327.1 C, SP 1710 C, VP 1.77 in Hg at 1000 C, 1 >• Hg at 970 C, 10 •• Hg at 1160 C
(COHTIlfOEDI
TISSOE
Blood
6126
Blood
61127
Blood
EXPOSURE BOOTS
Inhalation
ANALYTICAL
HETB00
AAS
AAS
NOHBEE
OF CASES
286
a) 13
b) 9
c| 8
d) 10
BANGS
b) Not given
c) Not given
d) Not given
e) Not given
f) Not given
h) Not given
a) 2-17 ug/100 ail
b) 3-10 ug/100 al
c) 5-13 ug/100 ml
a) Hot given
b) Mat given
c) Hot given
d) Hot given
REAM
b) 8 ug/100 Bl
c) 9 ug/100 •!
d) 8 ug/100 nl
e) 13 ug/100 al
f) 9 ug/100 •!
b) 9 ug/100 •!
a) 6.3 +or- 2.8
ug/100 Bl
b) 5.3 +or- 1.5
C) 9.4 tot- 3.2
d) 6.3 tor- 2.6
ug/100 »1
a) 0.95 tor- 0.09
u no 1/1
b) 1. 17 tor- 0.38
umol/1
c) 0.77 tor- 0.29
umol/1
UBOl/1
GENERAL IHFORBATION
uiits/vk. 111 ten
b) Non-sioXers, alcohol intake 2
QDits/vk, 231 voaen
c) Non-siokers, alcohol-abstraining,
13 Ben
80 voiec
e) Siokers (15-21 q tobacco/da;),
alcohol intake 12 units/wk, 161 >en
f) Siokers (15-21 q tobaccc/aav) ,
alcohol intake 4 units/irk, 128 voien
g) Siokecs (15-24 g tobacco/dar) ,
alcohol-abstaining, 7 Ken
h) Siokers (15-21 g tobacco/day).
Increased levels of siokers explained
by increased alcohol intake
Slotting contributed little to blood
Pb in alcohol-abstaining cases
10-yr olds, resident of Copenhagen,
?0« len, 518 voien
EEmiaCK; ADULTS; ELOOD: LEAD;
IICOHOLIC BETEB1GES; BIOACCO BOI. ATIOH;
SIIOKING; TOBACCOS
ug/100 >1
Turku. Beans fcoi other rural areas.
c) 5 children living < 500 • £to» Pb
sielting plant, Tikkurila. (lean
significantly higher than lean d)
d) 259 children, not living near
plant c)
No significant difference between age
groups, between urban and rural
light and heavy traffic density.
Finnish children, nevborn-7 yr elds,
(111 girls, 115 boys). 172 urban, 51
sielter and paint factory cperate.
FINLAND; AGt; CHILDBED; BLCOO; LEAD;
iOTOBOTIVE; »IS POllOTIOIl;
EIOACCDBDUTIOH; FBBES; GISOIIHE;
PAINTS; ?tm»L »RIAS; SBELTERS; OTB1N
ABCA5
. _
a) Norial renal function, creatinine
clearance >100 ml/min
b) Hild renal failure, creatinine
clearance 31-80 ll/iin
c) Boderate renal failure, creatinine
clearance 16-30 il/lin
clearance <16 il/ain
18 gen, 22 uoien, aged 18-72 yr
KIDNEI DISEASES; BLOOD: UBINE; LEAD
BEFEBESCE
Olsen. N.B.
Hollnagel, H.
1981
International Archives
of Occupational and
18:391-397
Bernberg, S.
1981
Environient 20:117-129
caipbell, B.C.
Elliott, H. L.
Meredith, p. A.
1981
Toxicology Letters
9:121-121
(NEXT PAGE)
OJ
UJ
-------
lead
7H39-92-1
El
AtB 207.2, HP 327.« C, BP T7»0 C, VP 1.77 mm Hg at 1000 C, 1 II Hg at 970 C, 10 im Hg at 1160 C
(COHTIMUKD)
TISSUE
6028
Blood
6<»29
Blood
Blood
6H31
Blood
6432
Blood
EXPOSURE HOtJTE
_
Ingest ion
.
.
AHALYTICAL "DflBER
HETHOD
..
AAS
OT CASES
1
a) «8
b) 50
c) 81
d) 83
e) 73
GAUGE
Not applicable
21. » 27.3 ug/ il
a) 0-10 ug/100 •!
b) 11-15 ug/100 Hi
c) 16-20 ug/100 «1
d) 21-25 ug/100 nl
e) 26-35 ug/100 »1
SEAN
70 ug/100 ll
_ .
a) Hot given
b) Not given
c) Not given
d) Hot given
e) Hot given
1
GENERAL IBFORSATIOB
6 yr old with sickle-cell anemia, and
peripheral neuropathy from paint
ingestion. Cose unknown
CBILDBEB; SE1AL POISOBIHG; NEUROLOGIC
HABIFESTATIOBS; BLOOD; ORIBE; LEAD;
BETJLS
Review
Ccrrelations between airborne Pb,
infants, children and adults are
difcussed
nWTED KINGDOn; DNITED STA1ES;
AEULTS; CHJLDREH; FETOS; BEWEOEH;
RACIAL STUDIES: SEI: BLOOD; BOOT;
CCHPAEATIVE EvlLOATIOHS; RE?IE»;
LEAD; BETAtS; AOTOHOTIVE; AIR
tOlLOTION; GASOLINE; HEALTB HAZARDS;
ROB1I JEB15; DRBAH AREAS
different laboratories
OIIITED KISGDOB; BLOOD; BEASOREaEHT
BETBODS; LEAD; BETALS; POPOLATIOH
Review
Effect of analytical variability on
interpretation of blood Pb data fcoi
il population studies is discussed.
«OH of variability in data attributed
to analytical error, resulting in
"false positive11 leasureaeots above
threshold li.its
ELOOD; HEUSOEEHENT BETHODS: BEVIEV;
LEAD; BETAIS
a) Bean (arithmetic and geoietric)
delta-aainolevulinic acid dehydratase
activity (AlA-d) 33.9 and 32.8
mol/iin/1 RBC
b) »LA-a 33.5 and 31.7 uioVii.n/1 SBC
c) ALA-d 32.3 and 30. « uiol/iin/1 RBC
d) »LA-d 31.6 and 29.3 uiol/iin/1 RBC
e) tLA-d 29. « and 26.3 uiol/iin/1 BBC
Statistical significance depends on
adequate choice of distribution
function of ALA-d, interindividnal
variability, analytical limitations.
and range of environmental exposure
Healthy nonoccupationally exposed
residents of Belgim
BELGIUM; ADOITS; ELOOD; LEAD;
LEVOLIHIC ACIDS; BET1LS; POPULATIOS
EXPOSURE
REFERE8CE
Anku, V.D.
Harris, J.H.
197H
Journal of Pediatics
85(3) : 337-310
Stephens, R.
1981
of Environnental
Studies 17: 73-83
Braughton, P.H.E.
Delves, B.T.
Elwood, P.C.
197H
1 (5907) :576
Lucas, J. fl.
1981
Aierican Industrial
Hygiene Association
Journal 12(2) : 88-96
Sartor, F.
Rondia, D.
1981
International Archives
of Occupational and
Environmental Health
«9:«5-51
1
1
(MS IT PAGE)
u>
.p-
-------
lead
7439-92-1
Pb
At« 207.2,
HP 327.4 C, BP 17HO C, VP 1.77 »m Hg at 1000 C, 1 •• Hg at 970 c, 10 mil Hg at 1160 C
(COBTINOED)
TISSUE
6(33
Plood
6434
Biooa
6435
Blood
6436
Bloofl
EXPOSURE ROUTE
Ingestion
Inhalation
&HAL5TICAL
METHOD
Fluorometry
Dithizone
A»S
IS
HOUSES
OF CASES
a) 5
b| 49
c| 149
d) 192
e) 170
f) 67
g) 32
h) 8
a) 201
b) 19
c) 11
31
5
MUGS
a) 100-190 ug/1
b| 200-290 ug/1
c) 300-390 ug/1
d) 400-190 ug/1
e) 500-590 ug/1
f) 600-690 ug/1
g) 700-790 ug/1 h)
800-890 ug/1
a) 0-0. 20 nig/1
b) 0.21-0.40 ng/1
c) >0,40 Kg/1
51-38 ug/100 ml
a) 0.17-0.25 ug/g
b) 0.08-0. 15 ug/g
WE AW
a) Not given
b) Not given
c) Not given
d) Not given
e) Not given
f) Not given
g) Not given
h) Not given
a) Not given
b) Not given
c) Not given
Not given
a) 19.4 ug/g
b) Not given
GEHEBAL I»FOP»ari08
a) 300(200-400) ug/1
bj 500(50-2000) ug/1
c) 600(200-0000) uq/1
d) 800(100-UOOO) ug/1
e) 1200(100-5000) ug/1
f) 1800(1000-7000) ug/1
g) 2200(1200-58001 ug/1
h) 3200(1100-5000) ug/1
Mean (range) erythrocyte porphyrin
Pciphyrin levels (expressed as
coproporphyxin 1} estimated fro*
graph
Children suspected of chronic Pb
ingestion plus nonselect children
from acute-care clinics, St. Louis
MISSOURI; CHILDHEM; ANEHIA; LEAD
POISONING; BLOOD; MEASUREMENT
BITHODS; LEAD
of 36 controls
No Pb intoxication observed
Iran
TEAM; ADD1TS; CHIIDHEM; BLCOD;
INDOSTEIAL HYGIENE; LEAD; METALS;
IBDOSTEIAL ATHOSPBEBES; OCCOPATIOHAL
HAZARDS
Initial and 18 MO values during a Pb
exposure abateaent prograi. Range of
• eans
BES YOBIt; CHILDEEB; HET»1 POISONISG:
E100D; LEAD; POP01A1I01I EIPOSOEE
a) Bean total Pb, 5 patients.
142-366 ug/aay
after 83-121 days of 105-201 ug/day
Pb(20«) nitrate (total daily intake
sane as prestudy) . Tracer
represented UOK-58% of total blood Pb
suggesting input fron other sources
such as skeleton or ataospbere. c)
Mean total Pb, 3 patients, 25-50 days
after entering lo«-pb, filtered-air
rccn
a),b) unfiltered air (0.1-2.1 ug
Eb/cu >), c) filtered air
(0.062-0.0087 ug Pb/cu •)
Estimated respiratory uptake 14 +or-
4 qg/day with exposures to 2 ug/cu •.
AIP POLUJTICH; DIETS; ISajlATIOS:
IEAD; BLOOD; HAIR ; NAILS; SKI8; 08IHE
EEFEBESCe
Hanna, T.L.
Dietzler, O.K.
Slith, C.B.
Gupta, S.
Zarkowsky, U.S.
1976
Clinical che.istry
22(2) :161-168
Sanai, G.H.
Ziai, ».
Ghiaai, A.
1975
EnTironaental Pollution
Proceedings of the
International Syaposiua
on Industrial
Toxicology, S. H. Zaidi
(Ed.), pp. 77-87
Klein, H.c.
Schlageter, H.
1975
Pediatrics
Babinovitz, n. B.
Retherill, S.W.
1977
Journal of Laboratory
and Clinical Hedicine
90(2) :238-248
(NEXT PJSE)
OJ
Ln
-------
Lead
7139-92-1
Pb
AtW 207.2, HP 327.4 C, BP 1740 c, VP 1.77 mm Hg at 1000 C, 1 nil Hg at 970 C, 10 mm Hg at 1160 C
(CONTINUED)
TISSUE
6*37
Blood
6038
Blood
6139
Blood
EXPOSURE ROUTE
Inhalation
Denial
ANALYTICAL
BETHOD
AAS
HAS
NUKBER
OF CASES
63
1
38
RANGE
a) 7-30 ug/dl
b) 31-59 ug/dl
a) Hot applicable
b) Hot applicable
c) Not applicable
a) Not given
b) 24-35 ug/dl
a) Not given
b) Not given
a) 3.7 uuol/1
b) 1.9 umol/1
c) 1.3 umol/1
a) 24.68 »or- 6.72
ug/dl
b) 29.6 ug/dl
GENERA! INFORMATION
a) 16 13-25 10 olds, 11 36-59 Id
olds, 5 60-75 mo olds
b) 13 13-25 mo olds, 12 36-59 10
elds, 3 60-75 >o olds
Results of neurobehavioral tests
provide evidence of altered CHS
function in young children Kith bod?
burdens below 30 ug/dl
Asymptomatic children, Host from
low-income. Black families in »c.
Potential exposure through parents
employed in Pb-rclated industries.
NORTH CAROLINA; CHILDREN; CENTRAL
NERVOUS SISTER DISEASES; LEAD
POISONING: BLOOD; LEAD;
BiOACCunuLAiioN; BET us
a) 1978
b) Dec 1979
c) Jan 1980
Source vas German paint powder
containing 472,750 ug/g Pb. Exposure
when patient Mixed powder and applied
to canvas vith hands.
27 yr old painter, United Kingdom
General malaise, nausea, vomiting,
colicky abdominal pain, constipation,
muscle pain and bilateral wrist drop
"Blue line1* on upper gingival margin.
Bone marrow sideroblastic.
Hemoglobin 7.4 g/dl, no basophilic
stippling. 12/79 measurements, Hb
was 12.0 g/dl and stippling was seen.
GEBHANT; nNIIED 1UHGDOH; ADULTS; LEAD
POISONING; BLOOD: ORINE; LEAD;
COSKETICS; I»HJLATICH; OCCUPATIONAL
HAZARDS; PAINTS; BETAL5
a) 2.5 yr after exposure. 16 of 38
had cnelation therapy
b) 5 subjects from a) who had Tit
levels > 50 ug/dl and serum Pe levels
< 70 ug/dl
Children, mean age 8.5 yr
No correlation between blood pressure
and Pb levels, FEP levels, or
relative amount of Pb released
following cnelation 2-5 yr «fter
initial exposure and therapy
CHILDREN; BLOOD; DEI1E; LEAD; BETALS;
ELOOD PRESSDBZ
(HEX? PAGE)
Otto, D.A.
Benignus, T.A.
auller, K.E.
Barton, C.N.
1981
Electroencephalography
and Clinical
Neurophysiology
52:229-239
Graham, J.A.G.
Haxton, D.G.
Twort, C.H.C.
1981
Lancet
2(8256) :1159-1160
Prielander, H.A.
Brooks, C.T.
Sheehe, P.£.
1981
Archives of
Environmental Health
36 (6):3 10-315
-------
lead
7439-92-1
Pt
At» 207.2.
BP 327.4 C, BP 17110 C, VP 1.77 u Hg at 1000 C, 1 •• H10 yr olds, Australia
1 children with Pb levels > 25 ug/100
prctoporphyrin level > 2.0 UBO!
AGSTIIU.il; CHILDBED; SEX: BLOOD;
LEAD; HETALS; HEALTH HAZARDS: MINING;
RURAL IDEAS
Increased levels generally produced
synchronized EE6 between P3 and Pit in
all frequency bands
Asynptonatic children, ages 13-75 BO,
•ost froa low-incoie. Black families
patents employed in Pb-related-
industries.
»GE; CHIIDREB; HEDSOIOGIC
HJNIFESTATIONS; ELOOD: LEAD: flETALS
a) Participants in Pb blood survey 5
yr earlier, 75 subjects
c) Children with above average
intelligence froa a) , 4 subjects
d) children with below average
intelligence froB a) , 6 subjects
Intelligence rated by classrooB
teacher
7-1Q yr old children, United KingdOB
UNITED KINSDOn; CHILDBED; IEAD;
FETALS; POPULATION EXPOSUBI
a) No syaptOBS o£ Pb poisoning
b) Biochemical, bat no clinical
syaptOBS of pb poisoning
c) Before and after chelation
therapy. Exposure unknown.
Antipyrine half- life decreased froi
11.5 to 6.0 hr
Antipyrene half-life decreased froa
lil.O to 9.6 hr
Antipyrine half-life used as index of
drug-Betabolizing capacity which, for
a) and b) , was twice that of
1-7.5 yr olds
CHILDREN; LEAD POISONING; BETAL
ECISOHI1IS; BLOOD! BLOOD PllStIA;
CEDGS; LEAD; HETALS ; BETABOLIStl
REFERENCE |
Heyworth, F.
Spickett, J.
Dick, B.
Rargetts, B.
Arastrong, B.
1981
Australia 2:232-234
Benignus, T.A.
Otto, D.A.
Buller, K.E.
Seiple. K.J.
1981
B lectroencepha lo gra p hy
and Clinical
Neurophysiology
52:2»0-248
liiqby, E. P.
1977
Lancet 2(8008) -.421
Alvares, A. P.
Kapelner, S.
Sassa, 5.
Kappas, A.
1975
Clinical Pharaacology
and Therapeutics
17(2): 179-183
U)
(HEX! PAGE)
-------
Lead
in 39-92-1
Fb
At» 207.2,
HP 327.U c, BP 1740 C, VP 1.77 mm Hg at 1000 C, 1 »» Hg at 970 C, 10 ui Kg at 1160 c
(CONTINUED)
TISSUE
Blood
6045
Blood
6 H46
Blood
6HH7
Blood
EXPOSOBE ROUTE
Inhalation
ANALYTICAL
METHOD
AAS
HAS
.
NHHBEB
OF CASES
1
65
GANGS
b) Hot applicable
c) Not applicable
a) 11.5-16. 1 ug/dl
b) 6.8- 17. <1 ug/dl
c) 10.7-16.6 ug/dl
d) Sot given
f) Hot given
Hot applicable
17-78 vig/100 al
HE AN
b) 35 ug/dl
c) 18 ug/dl
a) 1U.7 ug/dl
b) 10 ug/dl
c) 13.3 ug/dl
3) 3.8 ug/dl
f) 3.5 ug/dl
53 +or- 10 ug/100 g
36 +or- 13 ug/100 al
GENERAL INFORMATION
b) 2 «k after start of chelation
therapy
therapy
20 hr/wk exposure to Pb at pistol
range
11 yr old
contractions. Hyperglycemia and
Slycosuria with no acetonuria. At
aqe 28 BO patient had been treated
vith transfusion therapy fcr Pb
poisoning with encephalopathy
ADULTS; HEART DISEASES; LEAD
PCISOHING; B1TAL POISONING; BLOOD;
1E»D; HETALS
a) Americans, start of expedition
3) Himalayan men
f) Himalayan children
a)-c) same 1 subjects, d)-f) 103
altogether
Nepalese adults and 3-14 yx old
children. Adult Americans on
expedition in Nepal.
LEAD; BETILS; BIOACCtHIOLATION: BOEAL
JtEAS; BLOOD; ASIA; AUDITS; CHILDREN
Prospective blood donor
Tcung, healthy subject employed in
ADULTS; BLOOD; LEAD; BETALS;
INDUSTRIES; OCCUPATIONAL HAZARDS
Correlation Hith increased
prctoporphyrin levels, 58-557 ug/100
•1 erythrocytes, and vith decreased
d«lta-aminolevulinic acid dehydratase
activity, 1057-97 umol
pcrphobilinogen/hr/1 erythrocytes)
3-18 jc exposure to dust containing
Etc, pbSOU and Pb stearate
Bange estimated from graph
Polyrinyl chloride factory «or*ers,
Japan
INDOSTBIAL CHEHIC1LS; JAPAN; ADULTS;
BLOOD; INDUSTRIAL HEDICINE; LEAD;
IEULS; PEOTOPOBPHTHINS; DOST;
ENZIBES; IBDOSTHIaL ABEAS;
OCCDPATIOHAL HAZARDS
Marcus, S.H.
1981
Veterinary and Huaaa
Toxicology
23 (6): 42*-'*25
Piomelli, s.
Corash, L.
Corash, H.B.
Seaman, C.
Hushalc, P.
Glover, B.
Padgett, B.
1980
Science
:1135-1137
OO
HcGraw, T.E.
1981
Journal of the American
Medical Association
2«6(22):2625
Tomokuni, K.
Osaka. I.
Ogata, II.
1975
Archives of
Environmental Health
30(4)=588-590
(NEST PAGE)
-------
Lead
7139-92-1
It
Atw 207.2, flP 327.4 C, BP 1740 C, VP 1.77 in Hg at 1000 C, 1 in Hg at 970 c. 10 ui Hg at 1160 C
(CONTINUED)
TISSUE
6448
Blood
6449
Blood
6450
Blood
EXPOSURE EOOTE
Ingestion
Inhalation
ANALYTICAL
KETHOD
NUHBEB
OF CASES
16
BASGE
a) 18-40 ug/IOOg
b) Not applicable
c) Not applicable
d) Hot applicable
e) Not applicable
£) Not applicable
g) Hot applicable
h) Hot applicable
i) Hot applicable
j) Sot applicable
k) Not applicable
1) Sot applicable
n) Hot applicable
BEAN
a) 25 ug/IOOg
D) 24 ug/IOOg
c) U2 ug/IOOg
d) 56 ug/IOOg
e) in ug/IOOg
£) 10 ug/IOOg
g) 30 ug/IOOg
h) 32 ug/IOOg
i) 38 ug/IOOg
i) 28 ug/lOOq
k) 32 ug/IOOg
1| at ug/IOOg
m) 34 ug/IOOg
GESEEAL ISFORBATIOH
a) 16 controls, 31-602 days (nean 270
d), intake 97-33* ug/d (nean 181
ug/d)
b) Dietary supplement 300 ug/d foe
020 days, 1 subject
c) Dietary supplement 1000 ug/d foe
1095 days, 1 subject
d) Dietary supplenent 2000 ug/d for
646 days, 1 subject
e) Dietary supplement 3000 ug/d for
113 days, 1 subject
f) Postexposure (63 days), subject b)
g) Postexposure (283 days) , subject
c)
h) Postexposure (992 days) , subject
a>
e)
j) Bean 24-hr inhalation 1.9 ug/cu m.
112 days, 1 subject, (chaacer level
C.010 >g/cu e, 9 hr/d, 3.5 d/«k) ,
k) nean 24-b inhalation 7.0 ug/cu >,
112 days, 1 subject, (chanter level
C.019 «g/ca l, 10.5 hr/d, 6 d/vk),
lean dietary intake 248 ug/d
1) Mean 24-h inhalation 19.3 uq/cu •,
112 days, 1 subject, (chanter level
0.157 ag/cu «, 6 hr/d, 3.5 d/«k) ,
•) Hean 24-h inhalation 30,1 ug/cu B,
364 days, 1 subject, (chanter level
0.152 mg/c
-------
Had
7439-92-1
Pb
»t» 207.2,
US 327.4 C, BP 1740 C, vp 1.77 •• Kg at 1000 C. 1 » Kg at 970 c, 10 «a Hg at 1160 C
(COHIIHOED)
6151
Blood
6452
Blood
6153
Blood
EIPOSUBE fiOOTE
Ingestion
ANALYTICAL
OETHOD
NONBEB
OP CASES
9
a) 84
b) 106
c) 919
d) 98
635
deliveries
BANGE
a) Hot given
b) Hot given
a) 0.53-1.06 u»ol/l
b) 0.81-1.33 u»ol/l
c) 0.81-1.49 uuol/1
d) 0.71- 1.91 uiol/1
a) 2-23 ug/dl
b) 1-25 ug/dl
c) 1-25 ug/dl
d) Hot given
e) Hot given
f) Hot given
g) Not given
b) Not given
i) Hot given
j) Not given
k) Hot given
-
HE AS
a) 96.22 »or- 20.01
b) 57. 44 *or- 7.83
A) Hot given
b) Mot given
c) Not given
3) Not given
a) 9.73 *or- «. 1
ug/dl
b) 9.85 »or- 4.4
ug/dl
c} 9.82 *or- 4.8
ug/dl
d) 9.8 *or- 3.6 ug/dl
e) 9.5 *or- 4.4 ug/dl
f) 10.1 *or- 4.5
ug/dl
g) 9.2 *or- 3.9 ug/dl
h) 8.7 +cl- 3.6 ug/dj.
l) 9.5 »oc- ».0 ug/41
j) 9. 1 toe- 3.9 ug/dl
k) 9.4 »or- 3.9 ug/dl
GENIB1L INFORB1TION
a) Levels before treatment vitb
penicillaiine (PCI) foe 1 wk (3
patients) or 2 "k (6 patients)
b) Levels after treatment vith PCA
fcr 1 »k (3 patients) or 2 «k (6
patients)
Adalts employed in Pb recycling at
batter; cell factor;. Exposures
2-108 Booths.
BIIICO; iDOITS; LE»D POISONIHS;
BLOOD; ISDOSTEIAl BEOICIHE; LEAD;
HEALTH HAZABDS; INDDSTBI1L FLINTS
a) Hardvater area
b) Softvater area. North Kales
c) Softwater area, Scotland
d) Softvater area. North Hales
Bange of leans
Drinking water levels less than
0.05->0.30 »g/l
Volunteers, United Kingdom
OHITED KIHGDOK: ADOITS; BLCOC; LEAD;
DPIHKIBG MAIEE; HEALTH HAZABDS; BATES
POILOTION; SCOTLAND; SALES
(NEXT PAGE)
a) Cord blood, 154 cases
b) Mothers, group a), 21 hr
postpartui
c) Nevborns, group a), 24 br
postpartui
d) Preiatuie rupture of Beibranes, 56
cases
e) 579 controls for d)
f) Preten deliver;, 71 cases
9) 561 controls
h) Preclaipsia, 32 cases
i) 603 controls for h)
3) Heconiui staining, 123 cases
It) 512 controls for j)
d) -k) cord blood
Bange a), b), and c) estimated fro>
graph
a)-c) correlation coefficients highly
significant
d-k) no statistically significant
differences
aethers age 13-40 vr (lean 21.1 ;r),
tables Mean gestational age 39.6 vk,
•ean birth vt 3,211 g, indigent urban
population, KT
ItllTOCKI; ADULTS; SEUBCBN; BLOOD;
LEAD; BETALS; POBPBT8IIS; ZINC;
BIOACCOIUJLATIOH; POPDLATIOI EXPCSDBE;
PBEGIANCT; OBBAN ABEAS I
I
Zuniga-Charles, N.A.
Gonzalez-Raiirez, J.O.
Holina-Ballesteros, G.
1981
Archives of
Environmental Health
36(1) :40-43
Thoaas, H.F.
Elwood, P.C.
Toothill, C.
Norton, N.
1981
Lancet
1 (8228) : 10X7-10H8
Angell, N.F.
Lavery, J.P.
1982
Aierican Journal of
obstetrics and
Gynecology l»2(1):»0-46
-P-
O
-------
Lead
7«39-92-1
Eh
AtV 207.2, HP 327.4 c, BP 17110 C, VP 1.77 •• Hg at 1000 C,
ay at 970 c, 10 •• Hg at 1160 C
(CONTINUED)
TISSDE
6454
Blood
6455
Blood
6156
Blood
EXPOSURE BODTB
»Mirricju
METHOD
Colorimetry
MS
AJS
ASS
UDDER
OF C1SES
a) 1172
b) «72
377
a) 22
b) 21
c) 36
d) 44
e) 29
BAVGE
a) 8-50 ug/dl
b) 6-10 ug/dl
c) Not given
a) Hot given
b) Hot given
c) Hot given
a) 9.7-40.5 ug/100 ml
b) 15.5-W.3 ug/100 ml
c) 7.6-24.8 ug/100 Hi
d) 5.3-17.7 ug/100 ml
e) 5.9-21.4 ug/100 al
BE* 11
a) 20.2 +or- 1.48
ug/dl
b) 15.2 tor- 1.40
ug/dl
c) 16.6 tor- 1.34
ug/dl
Geometric mean
a) 24.8 »or- 1.35
ug/dl
b) 27.7 tor- 1.35
ug/dl
c) 27.0 tor- 1.29
ug/dl
Geometric mean
a) 26.1 »or- 10.0
ug/100 ml
b) 29.7 tor- 8.4
ug/100 Ml
c) 16.0 tor- 3.8
ug/100 »1
d) 10.7 tor- 2.8
ug/100 Hi
e) 12.7 tor- 3. 1
ug/100 »1
..
GBBSBll JSfOBfllTIOS
a) 1967-69. colorimetric analysis
b) 1976-90. iAS analysis
c) 1978-60 data, as if determined b;
cclorimetric analysis
Estimated dietary intake 279 ug/day
(1971) and 146 ug/day (1980)
a) significantly higher than c)
Banges estimated fro* graph
Preemployment exaimnations, identical
age groups, United Kingdoi
DKITED KIHGDOH; BLOOD; IHDDSTEIHL
nlDICIHE; tltD; BCTJLS;
BICtCCDBUltTIOH; FOODS; HJEL
4DDITI1TES; POPOHTIOH EXPOSURE
a) children in ovner occupied housing
b) Childr
c) Childr
in private rental housing
c in public rental housing
Bousing o cupied for at least 1 yr
a)-c) no ignificant difference
11. 7* of ariation in blood-Pb level
could be zplained by socioeconoiic
status and Measured environmental
variables (soil, exterior and
interior paint, houfie dust)
1-72
old children, CT, 197H-1977
CONNECTICUT: CHILDREN; BLOOD: LEAD;
ItEItLS; DRINKING 1UTEB; DUST; PIIHTS;
POPOLaTIOH EXPOS06E; SOILS; OBBiN
a) School 1, <1 k» froH shelter
b) School 2, <1 let fro. s.elter
c) School 3, 2.5 k» from smelter
d) school 4, rural
e) School 5, urban
a) and b) significantly higher than
c)
d) and e) significantly lover than c)
e) significantly higher than d)
Ho evidence of nearophysiological
dysfunction
11 yr olds living near ore smelter,
rural and urtan controls matched for
age and socioeconomic status
CHILDBEH; BLOOD; COHPaBiTIIE
BViLDaTIOHS; LEAD; flETlLS; INDUSTRIAL
lEItS; IHEOSTBIIL tTHOSPHEBES;
IBDOSTRIAL EBISSIONS; IHDDSTBI11
FLINTS; INDOSTBIH PCLLDTICH;
COCQL1IIOH EIPOSOBE; BOBA1 ABEAS;
SBELTERS; OBBAN »REJS
(SEII PAGE)
BEPEBEHC"
Oxley, G.B.
1982
International Archives
of Occupational and
Environmental Health
49:341-343
Stark, A.D.
Quah, R.F.
neigs, J.D.
DeLouise, E.B.
1982
Environmental
27:372-383
Guerit, J.n.
(feulders, n.
Amand, G.
Boels, H.A.
Buchet, J.P.
Lauwerys, B.
Bruaux, P.
Claeys-Thoreau, F.
Ducoffre, G.
LaFontaine, A.
1981
Clinical Toxicology
18(11) : 1257-1267
-------
Lead
7039-92-1
Eb
At» 207.2,
HP 327.lt c, BP 1700 C, VP 1.77 urn Hg at 1000 C, I mi flg at 970 C, 10 mm Hg at 1160 c
ICOSTISOED)
TISSUE
6157
6458
Blood
6059
Blood
EXPOSURE BODTE
Ingestion
nha tion
.
ASALYTICAl
HETHOD
»AS
AAS
SDflBER
OF CASES
1
a) 72
b) 121
ct 73
d) 58
296
BANGE
a) Hot applicable
c) Hot applicable
d) Not applicable
e) Hot applicable
a) Hot given
b) Hot given
c) Hot given
d) Hot given
a) Hot given
b) Hot given
c) Hot given
d) Hot given
e) Hot given
f) Hot given
g) Hot given
h) Hot given
i) Hot given
j) Hot given
k) Hot given
1) Hot given
HE AS
a) 72 ug/dl
c) 71 ug/dl
d) 84 ug/dl
e) 103 ug/dl
a) 17.75 tor- 5.73
ug/100 ml
b) 16.09 tor- 5.70
ug/100 ml
c) 13.36 tor- 0.66
d) 13.28 tor- 6.62
ug/100 ml
a) 29.52 tor- 7.78
ug/100 ml
b) 21.74 tor- 5.63
ug/100 ml
c) 28.05 tor- 7.10
ug/100 ml
d) 21.60 tor- 5.19
ug/100 ml
e) 29.99 tor- 5.56
ug/100 ml
£) 20.99 tor- 6.00
ag/100 ml
g) 28.60 tor- 8.09
ug/100 ml
h) 22.87 tor- 8.59
ug/100 ml
l) 29.02 tor- 7.67
ug/100 ml
j) 21.05 tor- 5.27
ug/100 ml
k) 29.07 tor- 6.59
ug/100 ml
1) 22.13 tor- 6.60
ug/100 ml
GEHERAL INFORMATION
a) (larch, 1979
c) 10 days after chelation therapy (1
g CaHa2-EDT» 2X/day foe 5 days)
d) 3 wk after c) (patient had not
e) 8 wk after c) , June 1979, prior to
2nd course of chelation therapy
f) September 1979
6 vk occupational exposure to
powdered pigient containing IX Pt>.
Fatigue, dizziness, suscular pain in
turning pain in atdoaen, epigastric
irritability, severe anemia.
splenoaegaly, and basophilic
stippling of red blood cells
HEW TORK; ADULTS; CASE HISTORIES;
LEAD POISONING; METAL POISCMING;
BLOOD; URIHE; DROG THERAPY; LEAC;
HETALS; ZINC; HEALTH HAZARDS;
INHALATION; OCCUPATION AL HAZARDS;
CIGRENTS
a) Crown Street School
t) Bourke street School
c) Sacred Heart School
d) Darlington School
7 subjects with levels of 30 ug/100
Children, grades 2*6, Sydney,
Australia
AUSTRALIA; CHILDREN; BLOOD; LEAD;
(1ETALS; POPOLATIOM EXPOSURE
a) 228 traffic policeiea (exposed)
b) 68 office duty policemen
(controls)
c) 27 exposed, <21 yr old
d) 8 controls, <21 yr old
e) 36 exposed, 26-30 yr old
f) 10 controls, 26-30 yr old
g> 24 exposed, >36 yr old
h) 8 controls, >36 yr old
i) 85 exposed, employed <* yr
j) 26 controls, eaployed <1 yr
k) 59 exposed, ei ployed >8 yr
1) 18 controls, employed >8 yr
Exposed group levels significantly
greater than controls
No correlation between blood Pb and
age or length of e«ploynent
Iran
IRAN; ADOLTS; BLOOD; LEAD; HETALS;
AUTOMOTIVE;' AIR POLIDTZOf; PDEt
ADDITIVES; FOHES; GASOLINE ;
OCCUPATIONAL HAZARDS; URBAN AREAS
REFERENCE
Fischbeic, A.
Anderson, K.E,
Sassa, S.
Ron, s.
Kappas, A*
1982
Journal of the American
Medical Association
2«7(1H) :2007-2009
Nolan, B.H.
1982
Medical Journal of
Australia 1 (2) :57
Farsai, H.
Salari, G.B.
Nadin, A.
1982
Anerican Industrial
Hygiene Association
Journal 43:373-376
(NEXT PAGE)
-------
Lead
7139-92-1
Ft
At» 207.2, HP 327.it C, BP 17140 C. 7P 1.77
Hg at 1000 C, 1
Hg it 970 C, to in Hg at 1160 C
(CONTINUED)
TISSUE
61460
Blood
6461
EXPOSURE ROUTE
ANALYTICAL
HETHOD
HAS
HUJIBEB
OF CASES
a) 21
b) «3
BINGE
a) 53.0-91.0 ug/100 ml
b| 17.0-29.5 ug/100 «1
BEAN
a) 70.5 ug/100 «1
b| Hot given
GENERAL IHFOBBATICN
a) Pb exposed workers
b) controls
5-95 percentile range
Workers at secondary Pb saelting
plant
GEBflANT; A DOLTS; BLOOD; DBIHE;
COnPAEATI»E CTALOtTIONS; IHDOSTBIAL
BEOICIHE; ClD«la«; LSIC; BEBCDRV,
BETAL5; PeOTEIDS; HEALTH HAZARDS;
INDUSTRIAL PLANTS; OCCUPATIONAL
HJZARCS; SBB1TE8S
Beview. children with asyiptOMatic
p«rforaances on intelligence tests
CHILDREN; IEAD POISONING; BETAL
POISONING; NEUROLOGIC HA1IIFESHTIONS;
EtOOB; BEVIES; LEiD: HETALE; SES
YCRK; HASSACHUSETIS
REFERENCE
Schaller, R.H.
Gonzales* J.
Thnrauf, J.
Schiele. R.
1980
Zenlralblatt £aer
Bakteriologie,
Parasitenkunde,
Infektionskcanlcheiten
und H7gieDev Abteilung
1. originals, Reihe B.
H;giene, preventive
Sedizin 171:320-335
Needleman, H. L.
Leviton, A.
1981
Pediatrics
68(6) : 8914-896
(HE1CT PAGE)
-------
Lead
7439-92-1
Pb
At» 207.2,
BP 327.4 C, BP 1740 C, If 1.77 m> Hg at 1000 C, 1 » Hg it 970 C, 10 •« Hg at 1160 C
(COHTIBOED)
TISSOE
6462
Blood
ET.POSDBE BOOTS
ANALYTICAL
METHOD
ASS
» cm BZE
OF CASES
BANGS
a) Mot given
b| Sot given
c) Hot given
d) Sot given
e) Sot given
f) Mot given
gj Mot given
h) Sot given
i) Hot given
j) Sot given
k) Mot given
1) Mot given
•) Sot given
n) Sot given
o) Hot given
p) Mot given
q) Hot given
r) Sot given
s) Sot given
t) Sot given
u) Hot given
»£.!»
a) 6.8 ug/dl
b) 7.5 ug/dl
c) 8.7 ug/dl
d) a. 7 ug/dl
e) 10.0 ug/dl
£) 37.4 ug/dl
g) 45.1 ug/dl
h) 50.9 ug/dl
i) UK. 6 ug/dl
j) 27.6 ug/4i
k) 46.3 ug/dl
1) HI. 4 ug/dl
m) 45.9 ug/dl
n| 46.8 ug/dl
o) 35.3 ug/dl
p) >50 ug/dl
g) >50 ug/dl
r) 5U.7 ug/dl
s) 67.5 ug/dl
t) 52.3 ug/dl-
u) 45.9 ug/dl
GENERAL IHFOBBATICN
M,
a) Age 0-3 yr, 37 cases
b) Age 3-5 yr, 10 cases
c) Age 5-10 yr, 19 cases
d) Age 10-1S yr. 6 cases
e) Age >15 yr, 1 case
f) Age 0-3 yr, 57 cases
g) Age 3-5 yr, 11 cases
b) Age 5-10 yr, 20 cases
i) Age 10-15 yr, 10 cases
j) Age >15 yr, 9 cases
k) Age 0-3 yr, 92 cases
1) Age 3-5 yr, 56 cases
•) Age 5-10 yr, 37 cases
D) Age 10-15 yr, 56 cases
0) Age >15 yr, 138 cases (tales 39.3
ng/dl, females 32. » ug/dl)
p) 63 of 99 children attending day
care center in area with highest air
PI level
g) 1 of 25 children attending day
care center in area near sielter but
west of prevailing find currents
refinery, and battery plant, 1978.
Hean age 32.2 yr. Mean erythrocyte
pictoporphyrin (EP) 11.1 09/9
beaoglobin (Hb)
age 35.9 yr. Sean EP 15.5 ug/g Hb.
7 cases blood-Pi) (B-Pb) >100 ng/dl
t) 03 children (<15 yr old), parents
employed in shelter, refinecy, and
battery plant, 1980
a) 241 children (<15 yr old), parents
not employed as in t) , living in saae
city, 1980
a)-e) 73 nonexposed controls, dean
tt 3.9-0.9 ug/g Bb. Highest B-Pb. 19
uo/dl
f)-j) 107 of 321 exposed area
residents, 1978. vith EP >8 uq/g Hb.
Bean EP 12.0-8.1 ng/g Hb. Dean air
Fb level, 14.3 ug/cu •. 7 cases
S-Pb, 73-86 igd
: M -1) 379 exposed area residents.
1S80. Mean EP 9.65-5.3 ug/g Hb.
Bean air Pb level. 23. 8 ug/cn •
f)-l) Data excludes workers and
families in lead-related industries.
Residents oC Kosovska Hitrovica. site
of largest land shelters in Europe,
and Pristina, 40 km south cf saelter
(no Pb emissions) , Jugoslavia
Children with extremely high
blood-Pb, neurological disorders.
bistory cf convulsions, learning
disabilities, anorexia, and/or
insomnia, workers* symptoms
consistent kith poisoning.
TOGOSI.1VI1; ADOLESCEDTS; 1 CHITS;
CBXIDBEK; LEAD POISOIIIG; BETA!
POISORIBG; BLOOD; LEAD; BETALS;
PtCTOPOKPOTBIHS; AIR POLL0TI08;
BIOtCCOBDLATIOI; DOST; HEALTH
BAZAEDS; IHDOSTSIAL AEEAS; IUDDSTSIAt
A1HOSPHEBE5; I1DDSTBIAL EBISSIOKS;
I8DDSTBIAL PLABTS ; UDOSTRIAl
POU.OTIOI; IMDOSTBIES; IIHALATIOI;
CCCUPATIOHH. BlIAEBS; POPOLITIOS
EIPOSHBE; SHELTERS: OEBif 1BIAS
EEFEBESCE
Popovac, D.
Graziano, J.
Seaman, C.
Haul, B.
Cclakovic, B.
Popovac, R.
Osiani, I.
Haxhiu. B.
Begraca. B.
Bozovic, z.
Bikic, B.
1982
Archives of
Environmental Health
37(1) :19-23
(BBIT PASE)
-------
Kad
7039-92-1
Pt
MM 207.2, BP 327.t* c, BP 171*0 C, VP 1.77 BID Hg at 1000 C, 1 mm Hg at 970 Cf 10 mta Hg at 1160 C
(COMTIN'JED)
TISSUE
Blood,
cells
6461
Blood ,
cells
6165
Biooa ,
cells
6466
Bloofl,
plasma
EXPOSURE RODTE
ANALYTICAL
BETHOD
US
A«S
NOBBE8
OF CASES
a| 1
b) 1
a> 6
b) 1«
cl 5
d) 5
a) 31
b) «8
c) 56
d) 17
e) 13
B&BGB
a) 176-76 ug/100 11
b) 73-96 ug/100 Hi
a) 29-60 ug %
b) 102-178 ug %
c) 168-208 ug %
d) 102-120 ug %
a) -7 ug/100 Ml
b) -7 ug/100 ml
c) -7 ug/100 si
d) -6 ug/100 ml
e) -<* ug/100 ml
(NEXT
BEIS
_ -
at Not applicable
b) Hot applicable
a) 112 +or- 4 ug %
b) 1U2 +or- 6 ug IE
c) 185 +or- 7 ug X
d) 112 tor- 3 ug %
a) 3. 10 »or- 0.31
ug/100 ml
b) 3.20 *or- 0.29
ug/100 «1
c) 3. 10 +or- 0.26
ug/100 ml
d) 3.10 »or- 0.28
ug/100 ml
e) 3.0 »or- 0.31
uy/100 ml
PAGE)
5ESIE1L 1RPOEBJTIOR
ccntaining S.
-------
lead
71439-92-1
Pb
At» 207.2,
HP 327.4 c, BP 1740 c, VP 1.77 ma Hg at 1000 C, 1 11 Bg at 970 C, 10 mm Hg at 1160 C
(CONTINUED)
TISSUE
6467
Blood,
plasma
6468
Blood,
whole
.
6469
6»70
Bone
EXPOSURE ROUTE
Ingestion
_
ANALYTICAL
BSTHOD
_
ES
NUMBER
OF CASES
a) 1
b) 1
c) 18
e) 20
f) 27
g) 22
hi 4
a) 1
b) 1
5
BANGS
a) 4.90-0.69 ug/100 ml
b| 1.69-0.66 ug/100 nil
c) 0.14-0.57 tig/100 ml
el 0.26-1.16 ug/100 ml
f ) 0.38-1.48 ug/100 ml
g) 0.48-3.96 ug/100 ml
h) 1.64-3.42 ug/100 ml
a) 78-37 ug/100 ml
b) 36-46 ug/100 ml
Not given
MEAN
a) Not applicable
b) Not applicable
o) 0.27 tor- 0. 11
d) O.H8 tor- 0.22
ug/100 ml
e) C.69 tor- 0.25
ug/100 ml
f) 0.99 tor- 0.40
ug/100 ml
g) 1.43 tor- 0.77
ug/100 ml
h) 2.64 tor- 0.73
ug/100 ml
a) Not applicable
b) Not applicable
6.0 tor- 3.6 ppm dry
»t
GENERAL INFORMATION
a) 2 hr and 221 hr after 100 mg.
Pre-dose level 0.57 ug/100 al
b) 2 and 48 hr after 100 ig. 1.59
0.39 ug 100/ml
c) Erythrocyte Pb <39 ug/100 ml
d) Erythrocyte Pb UO-79 ug/100 il
e) Erythrocyte Pb 80-119 ug/100 ml
f) Erythrocyte Pb 120-159 ug/100 ml
g) Erythrocyte Pb 160-179 ug/100 ml
h) Erythrocyte Pb >200 ug/100 ml
Combined data in c) -h) for Pb workers
and non-occapationally exposed
subjects
BLOOD; BLOOD PLASBA; COMPARATIVE
EVALUATIONS; BEHSOTESENT METHODS;
LEAD: BETALS: EPIIHEOCTIBS
a) 2 and 221 hr after 100 mg.
Pre-dose level 16 ug/100 ml
b) 1 and 2 hr after 100 mg. Final
measurement 38 ug/100 ml at 48 hr.
Pre-dose level 18 ug/100 ml
BIOOD; BLOOD PL ASS A; COMPARATIVE
EVALUATIONS; BE ASUS EnEBT BETHODS;
IEJD; BETAIS: EBITBBOCITES
BevieH
blood and total levels of Pb in
discussed
UNITED KINSC09; UNITED STATES;
A DOLTS; CHILDB2S; FETDS; SEBBOBN;
EACIIL SIODIES; SSI; BLOOD; BOOT.;
CCnPAEiTHE EVALOATIOSS; BEVIE«;
LEAD; METALS; ADTOHOTIVE; AIE
POIIOTION; GASOLIHE; BEiLTB BAZAFDS;
BOEAL AEEAS; UEBAN JBEAS
normal tissue
Autopsies
JAPAN; ADOLTS; ADTOPSIES; ADEENAL
GLANDS; AOBTA; BORES; HEABT;
INTESTINES; KIDNEIS; LI7EB ; LONGS;
LIBPH NODES; PANCBEAS; SPLEEN;
STOHACR; THIEOID GLANDS; TBACBEA;
ALDBINUB; BABIOfl; CADBIOH; CALCIOH ;
CBBOBIDM; COBALT; COPPER; IHON; LEAD;
BAGsEsina: MANGANESE; BETALS;
BOLIBDENOB; NICKEL; PBOSPHCBOS;
EOTASSIOB; SILICON; SILVER: SODIDM ;
STBOHTIUB: TIB; 1ITAHIDB; 7ANADIUB;
tISC; BIOACCUBULATION; HEAIIB
HAZARDS; OCCUPATIONAL BAZABDS;
TONGUE; ZIBCONIOB; ELEMENTS
REFERENCE
deSilva, P.E.
1981
British Journal of
38:209-217
deSilva, P.E.
1981
British Journal of
Industrial Medicine
38:209-217
Stephens, R.
International Journal
studies 17: 73-83
Teraokar B.
1981
Archives of
36(4): 155-165
(NEIT PAGE)
-------
lead
7439-92-1
Pt
At» 207.2, BP 327.4 C, BP 17140 C, If 1.77 mm Hg at 1000 C, 1 11 Hg at 970 C, 10 »« Hg at 1160 C
(CONTINUED)
TISSUE
6171
Bone
6472
Bone
6H73
Breath
EXPOSURE POUTE
Inhalation
ANALYTICAL
METHOD
Colorimetry
SUB BEE
OF CASES
a) 7
b) 5
a) 1
b) 1
0) 1
d) 1
») 1
b) 1
c) 1
d) 1
BASGE
a) 6-82 ppm
b) 2.1-4.9 pp«
a) Not applicable
b) Not applicable
c) Not applicable
d) Mot applicable
f) Sot applicable
a) 39. 2-52. OS
b) 38.3-73.8!!
c) 21.4-39.0%
d) 46.0-47.0)!
BEAN
a) 15 ppm
b| 2.85 ppm
Medians
a) 0.71 ppm
b) 1.4 ppm
c) 0. 16 ppm
d) 0.11 ppm
f) 1.1 ppm
Dry wt
a) 44.4 +or- 4.4SJ
b) 47.0 »or- 9.0?
c) 31.4 +or- 5.9%
d) 46.5 »or- 0.7S
GENERAL ISPCBdATIOK
a) Exposed group
fcj Controls
Autopsies, femur
Controls from unpolluted areas
AKTiaONy; ABSENIC; CADfllUH ; COPPER:
LEAD; BEBCURT: SELEHIOB: SILVER; TIB;
ZINC; BIOACCOBULATIOB; ISDOSTRIAL
ATBOSPHEBES; ISDOST8IAL PLANTS;
POPULATION EXPOSURE; SBELTERS; EOSES;
FErUB; COBPARATIVE EVALUATIONS;
SSEDEN: AUTOPSIES; OCCUPATIONAL
HAZARDS: HETALS
a) Bandible, Rauca Negra site,
recently exposed, pre-ceramic,
pre-ietallarglcal, date 45CO-3000 yr
before present (bp)
post-ceramic, proto-me tallurgical,
date 3000-2500 yr bp
c) Bandible, Hauca Gallinazo site,
metallurgical, date 2000-1400 yr bp
d) Bandible, another person, site c)
e) nandible, another person, site c)
f) yertebra, mummy of wealthy female
Egyptian, Ptolemic period, 2200 yr bp
Ratio atomic Pb to atomic Ca in bones
of Peruvians buried 1600 yr was
3XlO(E-e), compared to
2100-3500X10 (E-8) in bones of
present-day residents of England and
the United States.
Specimens from Viru Valley, Peru and
Egypt
IGTPT; PERU: UNITED KINGDOB; UNITED
STATES; SOSES: TEETH; BABIDB;
CALCIUB; LEAD: BIOSCCUBULATIOS
a) Chamber level 0.010 mg/cu m, 9
measurements
b) Chamber level 0.019 mg/cu m. 12
measurements
c) Chamber level 0.157 mg/cu m, 15
d) Chamber level 0.288 mg/cu m, 2
measurements
* cf dose retained (amount inhaled
less amount exhaled, divided by
Particle size 50*
-------
lead
7139-92-1
Pb
»tn 207.2,
HP 327.4 C, BP 1740 C, VP 1.77 mm Kg at 1000 C, 1 11 8 i
el 1
BANGE
a) Hot given
b) Not given
C) Mot given
d) Hot given
e) Hot given
t) Hot given
g) Hot given
h) Hot given
i) Sot given
j) Hot given
k) Hot given
1) Hot given
m) Hot given
n) Hot given
o) Hot given
p) Hot given
g) Hot given
rj Sot given
a) Hot given
b) 0.45-1.9 ppa
c} 0.90-1.7 ppa
d) Sot applicable
e) Hot applicable
Dry wt
(NEXT
MEAN
a 8.4 ppm
b 7.3 ppm
c 7.3 ppm
3 5.7 ppm
e 10.3 ppm
f 9.9 ppa
g) 10.6 ppa
h) 6.9 ppm
i) 6.2 ppm
I) 5.7 ppa
fc> 8.7 ppn
1) 5.4 ppn
IB) 15.8 ppm
n) 8. 1 ppm
o) 8.96 ppn
p) 6.75 ppm
q) 6.75 ppn
r) 13.26 ppm
s) 15.5 ppm
t) 15.7 ppm
u) 9.0 ppm
v) 6.1 ppm
w) 6.5 ppm
x) 5.0 ppm
7) 8.1 ppm
z) 6.6 ppm
Geometric
a) 0.82 *or- 0.47 ppm
b) 1.2 ppn
c) 1.3 ppm
a>v 0.54 ppm
e) Q.35 ppn
Dry wt
PAGE)
GENEEiL INFOBKtTIOH
a) nothers (100)
c) Bothers, 16-24 yr old («7)
d) Infants of c)
e) Bothers, 25-30 yr old (29)
f ) Infants o£ e)
g) Bothers, 31-H2 yr old (28)
h) Infants of g)
1) Bothers, parity 1 (02)
j) Infants of i)
k) Bothers, parity 2 (24)
1) Infants cf k)
») Bothers parity 3 (19)
n) Infants of •)
o) NorBOtensire Mothers (73)
p) Infants of o)
g) Hypertensive Bothers (13)
c) Infants o£ q)
s) nothers vith pretera births (9)
t) Infants of s)
u) Bothers with underweight newborn
(10)
T) Infants cf u)
w) Bothers with »a If or led infants (9)
y) Bothers with norkal infants (63)
z) Infants of y)
i) and B) , s) and y), and t) and z)
significantly different
Mo positive association for Pb in
BCthers and infants. Levels in
aethers of parity 3 or greater.
higher than in priaiparoas Bothers.
Inverse relationship between Pb in
BCthers* hair and gestational age.
FRANCE; » DO ITS; AGE; NEWBOBN; HUB;
CCBPJBATIVE ET1LOATIOKS; CADBIDH;
LEAD; BETALS; BIOiCCOB OLATIOH ; BLOOD
PEESSIIRE; PBEGHAHCI; BOtUL AREAS
a) HorBal healthy Ben
b) chroBiUB plating workers
c) chroBate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JAPAH; ADOLTS; AUTOPSIES; ADBEI1L
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEIS; LIVER; LOHGS;
IIBPH NODES; PANCREAS; SPLEEN;
STOHACH; THIBOID GLANDS; TRACHEA;
ALORIIUB; BAEIOfl; CIDHIOH; CALCIOR;
CEBOBIDB; COBALT; COPPED: IRON; LEAD;
BAGNESIOB; BANGAIESE; BETAIS;
BOLTBDENOH; NICKEL; FHOSPHCBOS;
POTA5SIOB; SILICON; SILVER: S&DIOB ;
SIROSTIOB: TIN: TITANIOB; VANADIDR;
ZINC; BIOACCOHDLATION; HEALTH
BAZABDS; OCCUPATIONAL HAZABDS;
TONGOE; ZIRCONIDB; ELEHENTS
EEfERENCE
Huel, G.
Boudene , C.
Ibrahia, B.A.
1981
Archives of
36(51:221-227
Teraoka, H.
1981
Archives of
BnvironBental Health
36(4)1155-165
oo
-------
lead
7439-92-1
El
AtW 207.2, HP 327.14 C, BP 17110 C, VP 1.77 mm Hg at 1000 C, 1 •• Hq at 970 C, 10 ma Hg at 1160 C
(CONTINUED)
TISSOE
6476
Intestine
6077
Kidney
6476
Liver
EXPOSURE BOOTS
ANALYTICAL
HETHOO
ES
ES
ES
« OH BEE | BAKGE
OF CASES
10
a) 8
b| 2
C) 3
•J) 1
e) 1
a) 9
t» 2
c) 3
d) 1
e) 1
Hot given
a) Hot given
b) 0.8-2.8 ppm
c) 1.8-4.0 ppn
d) Not applicable
e) Hot applicable
Dry wt
a) Hot given
i>) 2,4-4.0 pp«
c) 2.6-12 ppm
d) Hot applicable
e) Hot applicable
Dry wt
BEAN
1.6 +or- 0.67 ppa dry
wt
a) 1.3 »or- 0.95 ppm
b) 1.8 ppm
c) 2.6 ppm
d} 1.6 ppm
e) 0.35 ppm
Dry wt
b) 3.2 ppa
c) 8.2 ppm
i) 7. 3 ppm
e) 1.1 ppm
Dry wt
GENERAL INECRBATION
Normal tissue
Autopsies
Japan
JAPAN; A DOLTS; AUTOPSIES; ADREHiL
GLIHDS; lOBIk; BOIES; BElKt;
UTESIIBES; KIDNEYS; LIVER; LONGS;
1YI1PH NODES; FANCEEtS; SPLtEN;
STOKACH; TBIROID GLANDS; TliACHEA;
ALCHI80H; CARIDH; CADBIOB; CAICIDK;
CHROBIOH: COBALT: COPPEB; IBON; LEAD;
BAGBBSIOn; HANGANESE; BETALS;
BOLTBDENDn; NICKEL; PHOSPHCROS;
FOTissinn: SILICON; SILVERS SODIOH;
STRO«Ti0rt: UN: TITANIOB; VANADIOB;
ZINC; BIOACCOBDLATION; REAITH
BMIBBS; OCCOP>TIO» »L BAZASDS;
TONGOE; ZIRCONI0B; ELEBENTS
a) normal healthy len
b) Chromium plating uotkers
c) Chromate refining vorkecs
dj Airplane painter
e) stone mason
Autopsies
Japan
JIEAN; ADDLTS; ADTOPSIES; ADREXAL
GLANDS; AOR1A; BONES; HEART;
INTESTINES; KIDHEYS; LIVES; LONGS;
IYPPH SOOES; PtNCtJElS; SPLEEN;
STOBACH; THYROID GLAHDS; TBACHEl:
ALOBINOB; BARIOB; CADBIOB; CALCIOB ;
CBROBIDB; COBALT; COPPtR; IRON; LEAD;
BAGNESIOn; BANGANESE; BETALS;
BOLYBDENOB; NICKEL; PHOSPBOROS;
PCTASSIOB; SILICON; SILVER; SODIOB;
S1RONTIOB; TIN; TITANIOfi; VANADIOK;
ZINC; BIOACCOBOHTIOB: HBAtTH
HAZARDS; OCCOPATIONAL BAZABDS;
TONGOE; ZIRCONIOB; ELEBENTS
b) Chromium plating rockers
c) Chcomate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADOLTS; AOTOPSIES; ADREDIL
G1JNDS; AORTA; BOHES; HEARI;
INTESTINES; KIDNEYS; LIVER; LONGS;
IYBPR NODES; PANCREAS; SPLEEN;
STOBACH; THYBOID GLANDS; TRACHEA;
ALTOIHC!!; BABIOB-. CIDBIOB; CkLCIOH;
CHFOnlttH; COBALT; COPPEE; IRON; LEAD;
KAGNESIOB: BANGANESE; BETAtS;
BOLYBDENOB; NICKEL; PHOSPHCBOS;
PCTASSIOB; SILICOB; SILVER; SODIOfl ;
STBONTIOB; TIN: TITANIOB; VANADIOB;
ZINC; EIOACCOBOLATIOH; HEA ITH
HAZARDS; OCCOPATIOHAL BAZABDS;
TOHGOE; ZIBCOBIOB; ELEBENTS
REFERENCE
TeraoJca, H.
T981
Archives of
Environmental Health
36(11) : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
Teraoka, R.
1981
Archives of
36(11): 155-165
(NEXT PiGE)
-------
lead
7439-92-1
Pb
AtW 207.2,
HP 327.4 C, BP 1740 C, VP 1.77 mm Hg at 1000 C, t mi Hg at 970 C, 10 mi Hg at 1160 C
(COHTIHUEi))
T1SSDE
6H79
Liver
6480
Lung
6481
Lymph
node
EXPOSURE ROUTE
ANALYTICAL
BETHOD
ASV
LSV
ES
ES
-
NOB BEE
OF OSES
30
a) 12
b) 2
c) 3
d) 1
e) 1
a) 3
b) 1
c) 3
d) 1
e) 1
HANGE
0.8-2.3 ug/g
Set wt
a) ilot given
b) 4.0-4.2 ppm
c) 2.6-8.7 ppn
d) Hot applicable
e) Hot applicable
Dry wt
a) Not given
b) Not applicable
c} 4.1-5.8 ppm
d) Not applicable
e) Hot applicable
Dry wt
BEAN
Sot given
a) 1.3 *or- 0". 66 ppa
b) 4.1 ppm
c) 5. 8 ppm
d) 6.4 ppm
e) 0.95 ppm
Dry wt
a) 14.0 +or- 0.67 ppm
b) 5.5 ppu
c) 5.2 ppm
d) 6.5 ppm
ej 1.7 ppm
Dry wt
GEHEBAL INFOPHSTICH
Category 1 (first priority element)
as proposed by International Workshop
en Honitorinq Environmental HateriaLs
and Specimen Banking
Autopsies, Baltimore, HD,
Minneapolis, IIN, and Seattle, Hi
; WASHIHGTOB;
AUTOPSIES; 1IVEE : HEASHRBHENT
BITHODS; AlUniNBB; JBT1B01I'?; ARSEHIC;
EABIOB; CAD»IOB; CHBOBIOB; COBALT;
CCPPEB; FLDORINE; IEO»; 1EAD;
BAHGANESE; 8EPCDFT; nOLYBDEBOB;
NICKEL; BDBIDIOB; SELENIOB: SILVER;
S1BOS1ID11; TBALLIOM; TI»: VANADIOH;
ZIBC; POPDLATION EXPOSBBE
a) Normal healthy aen
b) Chromium plating workers
c) chronate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GIARDS; AOETA; BONES; HEART;
INTESTINES; KIDNETS; LITER; LONGS;
IISPH NODES; PANCBEAS; SPLEEN;
STOBACR; THIBOID GLANDS; TRACHEA;
iLOHITOH; BABItJll; CAEHIDB; CALCIOB;
CBBOHIOB; COBALT; COPPER; IBON; LEAD;
EAGNESIOB; BANGANESE; BETALS;
BOLYBDENOH; SICKM.J PHOSPHOBOS;
FOTASSIDB; SILICON; SILVER; SODIUM;
S1BONTIDB; TIN; TITANIOB; VANADTOB;
ZINC; BIOACCOMOLATIOH; HEA1TB
BAZABDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIECOSIUB; ELEHEHTS
a) Normal healthy nen
b) Chromium plating worker
c) chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; AEBENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNEIS; LIVER; LUNGS;
ITtPR NODES; PANCREAS; SPLEEN;
STOBACH; THIROID GLANDS; TBACHEA;
ALUIIIIDH; EABIDB; CADHIOD; CAICIDH;
CHBOHIUB; COBALT; COPPEB; IBON; LEAD;
KAGNESIDB; BANGANESE; BETALS;
BCLIBDENOM; HICKEL; PHOSPHCBOS;
POTASSIUM; SILICON; SILVER; SODIUH;
S1BONTIUB; TIN; TITANIUtl; VANADIUM;
ZINC; EIOACCUHULATION; HEALTH
BAZABDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIHB; ELEHERTS
Harrison, S.H.
Zexsler, R.
wise, S.A.
1981
EPA 600/S1-81-025, 6
pp.
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
Teraoka, H.
1981
Archives of
Environmental
36(4):155-165
(NEXT PAGE)
-------
lead
7139-92-1
Pb
AW 207.2,
Bp 327.U c, BP 17(0 C, If 1.77 mi Hg at 1000 C, 1 mi Hg at 970 c, 10 mm Hg at 1160 C
(CO BUDDED)
TISSUE
6482
6083
Spleen
64814
Stomach
EtPOSORE ROUTE
_.
ANALYTICAL
BETHOD
ES
IS
ES
KOBBE8
OF CASES
5
a) 9
b) 2
c) 3
d) 1
e) 1
10
etnas
Not given
a) Mot given
b) 2.5-1.5 pp»
c) 3.1-6.5 ppm
d) tfot applicable
e) Hot applicable
Dry wt
Hot given
(NEXT
BEAN
0. 76 +OIJ- 0.19 ppai
dry wt
a) 1.9 tor- 1.2 ppm
b) 3.5 ppn
c) <4.6 ppm
d) 5. 5 ppffl
e) 1.1 ppin
Dry wt
1.6 +or- 0.67 ppa dry
wt
PiSEl
GEBEBAL IBFORBATICN
Normal tissue
Japan
JAPAN: ADULTS; AUTOPSIES; IDBEMll
GLANDS; AOB1J; BORES; HEART;
INTESTINES; KIDNEYS; LIVES; LUNGS;
LYBPH BODES; PANCBEJS; SPLEEN;
S10BACH; THIEOID GLANDS; TSACHEA;
ALDBISOB; BABIOH; CiDBIDS; CALCIOB ;
CBBOSIHB; COBALT; COPPER; IHON; LEAD;
HAGRESlnfl; BANGANESE; HETA1.S;
BOLYBDEDOB; NICKEL; PBOSPHOHOS;
POTASSIOB; SILICOll; SILVER J SODIOfl;
S1BONTIOB; TIB: TITiHIOH; V1BADIH9;
ZINC; BIOACCOBOLATION; HEAITB
BAZ&RDS; OCCOPATIONtL BAZABDS;
TCBSOE; ZIBCONIHB; ELEHENTS
a) Normal healthy nen
b) Chromium plating workers
c) Chronate refining workers
3) Airplane painter
e) Stone nasoo
Autopsies
Japan
JAPAN: ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LY5PH NODES; PABCBEAS; SPLEEN;
STOHACH; THYBOID GL1BOS; TRACHEA;
ALOBINOB; BARIOB; CADBIOB; CALCIOB;
CBP.OBIOB; COBALT; COPPEB; IRON; LEAD;
BAGNESIDB; ilANGSNESK; BETAIS;
BOITBDBOTB; NICltIL; PHOSPHORUS;
POTASSIOH; SILICON; SILVER; SODIOB;
STRONTIOB; TIN; TITJNIDB; VABADIDB;
2INC; BlOACCOBtJLATION; HEALTH
HAZARDS; OCCOPATIONtL HAZAUDS;
TCSSUE: zmco»rff»; ELEHSIITS
Normal tissue
Autopsies
Japan
JACAR; ADULTS; AUTOPSIES; ADRENAL
GLAKDS; AO8TA; BOKES: HEA5T;
IHTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCBEAS; SPLIEB;
STOHACH; THYROID GLANDS; TRACHEA;
ALOHINUa; BABIUB; CADBIDB; CALCIUB;
CHROBIUB; COBALT; COPPER; IRON; LEAD;
BAGNESIOB: HANGANESE; BETALS;
BCLYBDENUB; NICKEL: PHOSPHORUS;
fOTASSIDH; SILICON; SILVER; SODIOB;
STRONTIOB: TIB; TITABIOB; VANADIOfl;
7IRC: BIOACCOBOLJTION: HBAlTIi
HAZARDS; OCCUPATIORAL HAZARDS;
TONGOE; ZIRCOBIOB; ELEHENTS
REFERENCE
Teraoka, H.
1981
Archives of
36{»): 155-165
Teraoka, H.
1981
Archives of
36(4); 155-165
Teraoka, H.
1981
Archives of
36(4): 155-1 65
-------
Lead
7039-92-1
Ft
»t» 20-?. 2,
HP 327.4 C, BP 17110 C, »P 1.77 im Hg at 1000 C, 1 •» Hg at 970 C, 10 II Hg at 1160 C
(COHTIN'JED)
TISSUE
6U85
Teeth
6U36
Teeth
6487
Thyroid
gland
EXPOSURE ROUTE
ANALYTICAL
BET HOD
AAS
ns
_
ES
NOflBEa
OF CASES
a) 54
b) 23
c) 38
d| 22
e) 7
f) OS
g) 36
h) 21
i| 19
1) 9
k) 27
1) '5
a) 1
b) 1
c) 1
d) 1
4
CAUSE
a) Hot given
b) Hot given
c) Sot given
d) Hot given
e) Hot give
f) Hot give
g) Not give
h) Hot give
i) Hot give
j) Sot give
k) Not given
1} Hot given
a) Not applicable
b) Not applicable
c) Not applicable
d) Not applicable
Not given
BEAN
a) 17.8 ppi
b) 16.8 pp»
c) 10.8 ppi
1} 19.9 ppn
e) 9.8 ppm
f) 10.1 ppi
g) 8.9 ppi
h) 5. 1 ppn
1) 11.0 ppi
j) 7.9 pp.
k) 10.8 ppa
1) 6.2 ppi
Geometric
a) 0. 10 ppi
b) 0.23 ppi
c) 0.04 ppi
d) 0.06 ppn
Dry wt
0.74 +or- O.t9 ppi
dry yt
GENERAL INFOBItATIOH
a) Urtan, Pb paint exposure, incisor
b) Sale as a) , cuspid
c) Saie as a) , lolac
d) Urban, recent public housing, but
within Pb paint area, incisor
€) Sale as d) , golar
f) Urban, no Pb paint pcoblei,
incisor
g) Sale as £), cuspid
h) Sale as f), lolar
i) Suburban, incisor
j) Sane as i) lolar
k) Industrial area, incisor
1) Saie as k), lolar
Deciduous teeth
children froi netropolitan St. Louis,
PC.
B1SSOOBI; CBILDRIS; TEETH; LEAD;
HETALS; OKEAK AHIiS
a) Rauca Regra site, recently
exposed, pre-ceraiic,
pre-ietallnrqical, date 4500-3000 yr
before present (bp)
b) Guanape ceaeterr, speciiens
exposed on surface 30 yr,
post-ceraiic, proto-ietallurgical,
date 3000-2500 yr bp
c) Huaca Gallinazo site,
•etallurgical, date 2000-1400 yr bp
d) Ancther person, site c)
Enaiel
Speciiens froi viru valley. Pern
EGYPT; PERU; UNITED KINGDOfl; D1IITED
S1ATES; BORES; TEETH; BARIDB;
CHLCIOH; LIU; BIOACCOBOL1TION
Moraal tissue
Autopsies
Japan
JAEAB; ADOLTS; AOTOPSIES; ADRENAL
CLAUDS; AORTA; BOMBS; BEAR1;
INTESTINES; KIDNEYS; LITER: LDRSS;
LYBPB NODES: PANCREAS; SPL1EN;
STOMACH; THYROID SLAIOS; TRACHEA;
• LtJBINDB; BI8IOB; CADBIOB; CALCIDB;
CBROniBB; COBALT: COPPER: IRO»; LEAD;
BAGIESIOa; BANGADESE; BETALS;
BOLIBDEBDB; NICKEL; PHOSPHORUS;
FCTASSIOB; SILICON; SILVER; SODIUM;
STOOimBB; in; TIT1KJH; IMUIVIi
ZINC; BIO ACCUMULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TORGDE; ZIRCONIOH; ELEMENTS
Lockeretz, B.
1975
Archives of
Environmental Health
30:583-587
Ericson, J. E.
Sbirahata, H.
Patterson, C.C.
1979
Nev England Journal of
Medicine
300(17):946-951
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
(SEIT PAGE)
-------
lead
7S39-92-1
Fb
AtB 207.2,
BP 327.» C, BP 17»0 C, VP 1.77 in Hg at 1000 C, I •• Hg at 970 C, 10 II Hg at 1160 C
(CONTINUED)
TISSUE
6488
Tongue
6089
Trachea
6090
Urine
6091
_
EXPOSUBE ROUTE
ANALYTICAL
BETHOO
ES
ES
A»S
H DB BEE
OF CiSES
_
2
2
a) 13
b) 9
c) 8
d) 10
1
BANGS 1 HEAN
Not given
Not given
a) Not given
b) Not given
c) Not given
d) Not given
a) Not applicable
b) Not applicable
1.2 + or- 0.28 ppm dry
»t
1.6 +or- 0.02 ppm dry
wt
a) 0.11 tor- 0. 08
umol/20 hr
b) 0. 15 »or- 0.08
umol/2« hr
c) 0. 10 tor- 0.05
u»ol/2« hr
d) 0.13 *or- 0.10
umol/20 hr
a| 120 ug/1
. ug
GESERAL INFORBATION
Norval tissue
Autopsies
Japan
JAPAN; ADULTS; AOTOPSIES; ADBENAL
GLANDS; AORTA; BOHES; BEART;
I8TESTINES; KIDNEIS; LIVEE: LONGS;
llnPH NODES; PANCEE1S; SPLEEN;
STOBACH; THIEOID GLASDS; TBACBEA;
ALOBIHOn; BtEIDIt; CADHIUII; CALCIOH;
CBBOBinn; COEALT; COPPER; IRON; LEAD;
HAGNESIOK; HANGANESE; KSTAIS;
BOLIBDESnil; BICKEI; PBOSPHOBDS;
POTASSIDB; SILICON: SIIVZB ; SODIUB;
S1RONTIDS; TIN; 1ITANIOS; VAHADIUB;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TON5UE; ZIRCOHIDB; ELEBENTS
Mornal tissue
Autopsies
JAPAX; ADULTS; ADTOPSIES; ADRENAL
GLAHDS; AOBTA; BONES; HEART;
INTESTINES; KIDNZTS ; LIVES; IOKGS;
LIBPH NODES; PANCEEAS; SPLEEN;
STOrACH; THIROID GLANDS; TRACHEi;
ALtlKINUn; BABIUB; CADBIUB; CALCIU8;
CPPOBIDB; COBALT: COPPER; IRON; LEAD;
HAGNESIOH; 9ANGANESE; BETAIS;
BOLIBDENUfl; NICKEL; PHOSPHORUS:
POTASSIUB; SILICON; SILVER; SODIUB ;
S1RONTIUB; TIN; TITANID9; VASADIUB;
ZINC; BIOACCUnOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZAEDS;
TONGUE; ZIRCONIUB; ELEHENTS
a) Noroal renal function, creatinioe
clearance >100 Bl/ain
b) Rild renal failqre, creatinine
clearance 31-80 >l/nin
c) Moderate renal failure, creatinine
clearance 16-30 il/ain
d) Severe renal failure, creatinine
clearance <16 *l/ain
Pr. clearance was not influenced by
degree of renal failure
18 Ben, 22 women, aged 18-72 vr
KIDNEY DISEASES; BLOOD; UBINE: LEAD
a) During hospital stay
EDTA
6 yr old with sickle-cell anenia, and
peripheral neuropathy due to paint
ingestion.
vrist and foot drop
CBILDPEN; BITAL POISONING; NEOEOLOSIC
HAHIPESTATIOKS: BLOOD; ORISE; LEAD;
BITALS
REFERENCE
Teraoka, H.
1981
Archives of
Environiental Health
36(0): 155-165
Teraoka, H.
1981
Archives of
36(«): 155-165
Canpbell, B.C.
Elliott, H.L.
Beredith, P. A.
1981
Toxicology Letters
9: 121-120
Anku, V.D.
197K
Journal of Pediatics
85(3):337-3»0
(NEXT PJG£)
-------
lead
71439-92-1
Pb
At" 207.2,
9P 327.4 C, BP 1740 C, If 1.77 n. Bg at 1000 C, 1 •> Hg at 970 C, 10 am Hg at 1160 c
(CONTINUED)
TISSUE
6492
Urine
6493
Orine
64914
Irine
61195
nrine
FXPOStlBE ROUTE
Ingestion
Ingestion
Inhalation
Inhaiation
Dermal
ANALYTICAL
METHOD
ns
AAS
NUMBER
OF CSSE3
5
1
38
BANGE
31-472 ug/24 hr
27-38 ug/day
a) Not applicable
b) Not applicable
17-117 ug
HE AN
Not given
32.6 ug/day
a) 15,300 nmol/24 hr
b) 300 nmol/24 hr
50.7 +or- 29 ug
GENERAL INFORHATION
6-8 wk exposure to drinking water
vith 8.4 mg/1 Pb
19-36 yr old male employees of Dining
company, 27 yr old female cook and
3.5 yr old daughter, Australia
Peripheral neuropathy, sweating,
lethargy, abdominal pain,
hypothermia, anorexia, nausea.
AUSTRALIA; ADULTS; CHILDREN: HETAL
POISONING; BLOOD; LEAD; HETALS;
CHINKING WATEB; GROUND HATER
POLLUTION; OCCUPATIONAL HAZARDS
Output from subjects living in room
vith unfiltered air and ingesting
diet containing 142-366 ug/day
AIR POLLUTION; DIETS; INHALATION;
IEAD; BLOOD; HAIR; NAILS; SKIN; DRINE
a) During 3.5 yr, periodic use of
paint powder containing 472,750 ug/g
Pb
c) 3 mo after removal of exposure
source
27 yr old painter, United Kingdom
General malaise, nausea, vomiting,
colicky abdominal paio, constipation,
muscle pain and bilateral wrist drop
"Flue line" on upper gingival margin.
Bone marrow sideroblastic.
Hemoglobin 7.4 g/dl, no basophilic
stippling. 12/79 measurements, Hb
was 12.0 g/dl and stippling was seen.
GF.SHAKY; UNITED KINGDOM; ADULTS; LEAH
POISONING; BLOOD; URINE; LEAD;
COSHETICS; INHALATION; OCCUPATIONAL
BAZABDS; PAINTS; BETALS
[NEXT PAGE)
6 hr excretions after chelation (25
mg/kg oral penicillamine). Hean
increase was 7.6 tor- 9.5 ug/dl.
Subjects exposed to Pb 2-5 yr
previously and 16 received chelation
therapy then.
Children, mean age 8.5 yr
No correlation between blood pressure
and Pb levels, FEP levels, or
relative amount of Pb released
following chelation 2-5 yr after
initial exposure and therapy
CHILDREN; BLOOD; DEINE; LEAD; BETALS;
| HOOD PBESSORE
J
BEFEBENCE
Stack, E.H.
Cleland, L.G.
1974
Medical Journal of
Australia
1 (26) : 1038-10H 1
Rabinouitz, H. B.
Betherill, G.8.
Kopple, J.D.
1977
Journal of Laboratory
and Clinical Medicine
90 (2): 236-248
Graham, J.A.G.
naxton, D.G.
Twort, C.H.C.
1981
Lancet
2(8256) : 1159-1 160
U1
Frielander, H.A.
Brooks, C.T.
Sheehe, P.B.
1981
Archives of
Environmental Health
36(6)-. 310-315
-------
Lead
7U 39-92-1
Pb
At» 207.2, B.P 327.4 C, BP 1710 C, If 1.77 nn Hg at 1000 C. 1 mm Hg at 970 C, 10 »» Kg at 1160 C
(COSTINnED)
TISSDE
61196
Orine
6497
Orine
1
1
EXPOSOBE POUTE
Ingestion
Inhalation
Ingestion
Inhalation
ANALYTICAL
HETHOD
I UMBER
OP CASES
16
1
SANSS
a) 19-45 ug/d
b) Not applicable
c) Sot applicable
d) Not applicable
e) Not applicable
f) Hot applicable
g) Hot applicable
h) Not applicable
i) Not applicable
j) Sot applicable
k) Not applicable
1) not applicable
m) Sot applicable
Not applicable
MEAN
a) 29 ug/d
b) 32 ug/d
c) 81 ug/d
d) 109 ug/d
e) 78 ug/d
£) 18 ug/d
g) 60 u/d
h) 14 ug/d
i) 33 ug/d
]) 31 ug/d
k) 39 ug/d
1) 66 ug/d
B) 78 ug/d
30.7 mg
GENERAL IHFORBATIO"
a) 16 controls, 31-602 days (lean
2704) , intake 97-331 ug/d (lean 191
ug/d)
b) Dietary supplement 300 ug/d for
420 days, 1 subject
c) Dietary supplement 1000 iig/d for
1095 days, 1 subject
d) Dietary supplement 2000 ug/d for
646 days, 1 subject
e) Dietary supplement 3000 ug/d for
113 days, 1 subject
f) postexposnre (63 days), subject b)
g) Postexposure (283 days) , subject
c)
It) Postexpocure (992 days) , subject
a>
i) Postexposure (166 days), subject
€)
j) Bean 24-h inhalation 1.9 ug/cu >,
112 days, 1 subject, (chanber level
C.010 »g/cu i, 9 hr/d, 3.5 d/vk) ,
k) Bean 24-h inhalation 7.0 ug/cu *,
112 days, 1 subject, (chaiber level
0.019 mg/cu m, 10.5 hr/d, 6 d/vk).
1) (lean 24-hr inhalation 19.3 ug/cu
•, 112 days, 1 subject, (chaaber
level 0.157 mg/cu », 6 hr/d, 3.5
d/wk) , Bean dietary intake 260 ug/d
•) Nean 24-hr inhalation 30. 1 ng/cu
i, 361 days, 1 subject, (chaiber
level 0.152 mg/cu a, 7 hr/d, 5 d/»k) ,
Exposure periods j) , kt , and 1) not
long enough to reach eguilibriui
Faraaeter response due to chaiber
exposure not apparent at exposure
rates <75 ug/cu •
Dietary supplementation, Pb acetate
solution, one-third vith each Deal
11 Caucasians, 5 Blacks. Age 22-55
yr (nean 31 yr)
CBIO; ADULTS; BLOOD; LONGS; DBINE;
1EAD; BIOACCOBOLATION; DIETS;
I»HALATIO»; PAETICOLATIS; BETALS
Total excreted during chelation
therapy (1 g CaBa2-EDTA 2I/day for 5
days)
43 yr old art conservator, NY
Fatigue, dizziness, muscular pain in
extremities, weakness of legs,
burning pain in acdoaen, epigastric
irritability, severe anemia,
splenomegaly, and basophilic
stippling of red blood cells
Nf» IOBK; ADOLTS; CASE HISIOBIES;
LEAD POISONING; BET HI POISONING;
BIOOD; OEISE; DEOG THERAPY; LEAD;
BETILS; ZIHC; HEALTH HAZARDS;
INHALATION; OCC0P ATIOHAL HAZARDS;
FIG8ENTS
(HKX.T PAl>£)
REFERENCE
Gross, S.8.
1981
and Environmental
Health 8:333-377
Fischbein, A.
Wallace, J.
Anderson, K.E.
Sassa, S.
Kon, S.
Rohl, A.N.
Kappas, A.
1982
Journal of the American
HedicaL Association
247(14) :2007-2009
01
Ul
-------
lead
7139-92-1
Pb
At« 207.2, BP 327.4 C, BP 1740 C, »P 1.77 n Hg at 1000 C,
ad at 970 C, 10 ii
6498
Orine
EXPOSDBE BOOTE
»»ALYTICAL
BETHOD
AAS
NOBBEB
OF CASES
a) 21
B1HSE
a) 53.0-96.0 ag/g
b) 6. 1-29.8 ug/g
creatiaine
Hg at 1160 c
(COSTISOED)
BEAN
a) Sot given
b} Not given
GtHIRAL IHrOBBATIOH
a) Exposed
b) controls. Median 12.5 ug/g
creatinine
5-95 percentile range
Workers at secondary Pb sielting
plant
GBBBAHY; ADULTS; BLOOD; OR IDE;
COBPABiTIVB EVJLOaTIOHS; IMD0STBUL
BEDICIHE; CADBIOB; LEAD; BEBCBBT;
BITALS; PBOIEIHS: SEM.TH HIZABDS;
IND0STBIAL PLAHTS; OCCOPATIOHAL
HtZABDS; SBELTEBS
BEFEBMCE
schaller, K.B.
Gonzales, J-
Thorauf, J.
Schiele, B.
1980
Zentralblatt fuel:
Bakter iologie.
Parasitenkunde,
Infektionskrankheiten
und Hygiene, Abteilung
1. Originale, Beihe B.
Hygiene, Preventive
Bedizin 171:320-335
1
{
•-Xylene (8 CI)
Benzene, 1,3-dinsthyl- (9 CI)
108-38-3
C8-H10
«« 106.16, BP -«7.» C, TP 10 •» Hg »t 28.3 C
61199
Blood
EIPOSOBE BOOTE
InhaXation
ANALYTICA1.
BETHOD
GC
NOBBED
OF CASES
22
BAKGE
a) 7-8 umol/1
b) 15-30 u«ol/l
cl 30-10 uioZ/1
d) 8-15 u»ol/l
e) 15-50 u»ol/l
41 40-100 uiol/1
KE&S
a) Hot given
b) sot' given
c) not givea
d) Sot given
e) Not given
i) Hot given
G 5 SEP* 1, J»POH»»TIO»
a) constant 100 PP»» day 1,6
subjects
b) Constant 100 pp«, with
intermittent exercise, day 1, 8
subjects
c) Fluctuating 70-200 ppi (mean 100
ppa) , with exercise* day 1 , 8
subjects
d) Sa»e as a) , day 5
e) Same as b) , day 5
f) Sane as «) , day 5
exposure) and afternoon (3 hr
exposure) . on day 5 afternoon
exposures were doubled (200 ppi in d)
and e) and 130-400 (Bean 200) pp» in
Esti Bated froB graph
Healthy 18-35 yr olds
lapairaent of body balance and
increased reaction tiae
IMDUSTRIiL CHEMICALS; BHEATfl; TTLBHE;
IHHALATION; BLOOD
1
Siihiia
Savolai
1980
Annals
Hygiene
(NEXT PAGE)
-------
•-lylene (8 CI)
Benzene, 1,3-di««thyl- (9 CI)
108-38-3
C8-H10
By 106.16, HP -H7.I1 C, vp 10 » Hg at 28.3 C
(CONTINUED)
TISSUE
6500
Blood
6501
Breat h
6502
Breath
EXPOSURE ROOTE
I a halation
Inhalation
AMLTTICM.
HETHOD
ac
GC
GC/BS
_
NUBBER
OF CASES
10
22
28
BiHGB
a) Hot given
b) Sot given
c) Hot given
d) Hot given
a) 1.8-0.008 u no 1/1
b) 2.5-0.009 uiol/1
c) 2.0-0.005 umol/1
d) 0.5 - 0.008 u»ol/l
e) 0.» - 0.005 unol/1
f) 0.6 - 0.008 UMOl/1
0.07-2.5 ng/1
a) 22.1 +or- 2.5
umol/1
b) 32.9 +or- 8.2
uiol/l
c) 40.7 +or- 12.9
uool/1
d) 65.6 +oc- 12.5
ana1/1
Not giv<
Hot givt
Hot giv*
Not giv«
Not giv<
Not giv*
0.5 ng/1
{KBIT PAGE)
GENERAL ISFOBHATION
a) 7.7 and 5.9 uaol/1 time-weighted
average concentration in air fTHA) , 5
subjects each exposure
b) 5.9 UBOl/1 THA, 10 subjects
c) 10.7 and 11.5 o«ol/l TWA, 5
subjects each exposure
d) 11.9 umol/1 TMi, 10 sabjects
Mean peak levels, 4 hr exposure
periods
Healthy 21-26 yr olds, wt 65-82 kg
Fsychophysiological functions
impaired. Deleterious effects of
•-xylene and alcohol usually
additive. Antagonistic effects on
body balance at the higher xylene
level
FINLAND; ADULTS; BLOOD; DROGS;
ALCOHOLS; ALCOHOLIC BEVERAGES;
ATMOSPHERE; IHHALATTOW; SOLVENTS
a) 0 and 5 hr postexposure after
constant 100 PP». day 1, 6 subjects
b) 0 and 16 hr postexposure after
constant 100 PP»* with interiittent
exercise,, day 1, 6 subjects
c) *0 and 16 br postexposure aftec
fluctuating 70-200 ppv (lean 100 ppa)
vith intermittent exercise, day 1, 8
subjects
d) 0 and 6 hr, sane as a) , da; 5,
afternoon exposure 200 ppm
e) 0 and 68 br, same as b) , day 5,
afternoon exposure 200 pp«
f ) 0 and U5 br, saae as c) , day 5,
afternoon exposure 130-400 (mean 200)
ppa,
Exposures 3 br ID doming and 3 hr in
afternoon
Esti sated fron graph
Healthy 18-35 yr olds
Impairment of body balance and
increased reaction tiae
IBDHSTRIAL CHEHICALS; BREATH;
INHALATION
Estimated from graph
Healthy 18-60 yr olds, nonsiokers.
Rigid protocol 14 d ays before a nd
during study to mininize number and
anount of exogenous constituents.
AUCLTS; BEEATH; ALCOHOISj CHLOBISE
ORGANIC COKP00NDS: CHLOPObENZENES
Savolainen, K.
1930
Acta Pharaacologica et
Toxicologica
16(5) :366-372
Riihisaki, V.
Savolainen, K.
1980
Annals of Occupational
Hygiene 23:411-422
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, H.P.A.
1977
Journal of
Chroiatographic science
15:239-241*
-------
1-lCylene (8 CI)
Benzene, 1,3-dimethyl- (9 CI>
108-38-3
ce-HtC
fl» 106.16, BP -«7.« C, »P 10 mm Hg at 28.3 C
(COHTINTCD)
TISSUE
6503
Breath
6504
Orine
"EXPOSOKE ROUTE
Inhalation
Inhalation
AMLITICAL
HETHOD
iOBBEfi
' CUSES
BINGE
a) 51. 0-67. 5%
b) H9. 3-72*8%
a) 0. 7-0. 9 g/8 or
b) 0.7-1.2 g/8 hr
C) 1.0-1.3 g/2H hr
-------
ragnesiun
7H39-95-*
Hg
AtB 2H.305, Kf 651 C. BP 1100 C, VP 1 •» Hg at 621 C, 10 » Bg at 740 c
TISSDE
6505
Adrenal
gland
6506
Aorta
6507
Blood,
6508
Blood,
se rum
1
EXPOSOBE ROUTE
_
...
A NAUTICAL
HETHOD
ES
ES
AAS
AAS
«. OH BEE
OF CASES
7
7
133
a) 26
b| 21
c) 52
d) 11
e) 10
f) 21
g) 10
h) 10
i) 10
.
BADGE
Not given
Not given
a) Not given
b) Hot given
a) Mot given
bj Hot given
c) Hot given
dl Mot given
e) Hot given
f) Hot given
g) Not given
h) Hot given
i) Hot given
_ _
MEAN
«90 +or- 300 ppjs dry
wt
700 +or- 230 ppiu dry
wt
a) 1.79 +or- 0.012
yffiol/1
umol/1
a) 20.6 +or- 0. 7 ppm
o) 19.5 o-O.l ppm
c) 19.5 o - 2,5 ppoi
d) 20.3 0-1.4 ppm
e} 20.3 o - 0. 5 ppm
f) 19.7 o-1.7 ppui
g) 20.6 0-0.6 ppm
h) 21.1 0-0.4 ppm
i) 21.1 0-2.9 ppm
GEHEBAL IHFORHATIOS
Honal tissue
Autopsies
TONGUE; ZIHCONIOH; ELESENTS; JAPAN;
ADULTS; AUTOPSIES; ADPEKAL GLANDS;
AOBTS; BOSES; BEAST; ISTBSTISZS;
KIDKEIS; LI1TEB; LUNGS; LYdPH HODES;
SPLEEN; PANCREAS; STOBACH; THTSOID
GLAHDS; TRACHEA; ALOBIHD9; BABIOd;
CADBIOB; CALCIOH; CHBOBIOB; COBALT;
COPPEB; IRON; LEAD; 8JGSESIOB;
MANGANESE; BETALS; BOLIBDENDB;
NICKEL; PHOSPHOBUS; POTASSIOB;
SILICON; SILVEB; SO DID B; STBONTIDB;
TIN; TITANIUB; VAHADIOH; ZINC;
BIOACCUBULATION; HEALTH HAZABDS;
OCCUPATIOSAL HAZARDS
Noraal tissue
Autopsies
TONSOE; ZIBCONIDB; ELEBENTS; JAPAN;
ADOLTS; AUTOPSIES; ADBEUll GLANDS;
AORTA: BONES: BBABT; IBTESIINES;
KIDBBTS; LIVEE; LONGS; LIBPH NODBS;
SPLEEN; PANCREAS; STOHACH; THTEOID
GLANDS; TRACHEA; JU.UHI8HK; BARIO)!;
CADBIUB; CALCItJB; CHBOBIUB; COBALT;
COPPEB; I80N; LEAD; HAGNESIOB;
KANGANESE; HETALS; BOLTBDENDB;
KICItSL; PHOSPHORUS; POTASSIO»:
SILICOH; SILVEE: SODMS; STSONTIOB;
TIN; TITANIOB; 'ANADIHB; ZINC;
BIOACCOIUJLATION; HEALTH HAZARDS;
OCCnPJTIOKiL HAZARDS
a) 102 healthy controls
b) 31 patients with acute myocardial
BLOOD PLASBA; CABDIOVASC01 AR
DISEASES; HEART DISEASES; COPPER;
BAGNESIOB; BANSANESE; ZINC
a) Lung and respicatory tract
b) Gastrointestinal tract
c) Bceast
d) Cervii
e) Lymphatic leukeaia
f) Halignant nelaoomas
g) Hodgkin's lynphona
h) Healthy volunteers
i) Geriatric patients
a)~9> type cf cancer
No significant difference between
geriatric patients (65-81 yr olds) ,
OK
UNITED KINSDOB; CARCINOBAS; LEOKEBIA;
KELASOUSS: NEOPLASBS; SAECOBAS; BLOOD
SERdB; CALCIOS; COPPER; BAGNESIOH;
BAHGANESE; BETALS; ZINC;
BIOINDICATOBS
_
SEPERENC5
Teraoka, a.
1981
Archives of
36(4) : 155-165
Teraoka, H.
1981
Archives of
36 (»): 155-1 65
zuikley, H.
Bertram, R.p.
Tank. B.
Hirth, ».
1980
Trace Substances in
Environnental Health
V1V, D.D. Henphill, ed.
pp 211-216
Capel, I.B.
Pinnock , H. H.
Uillians, D.c.
Hanhan, I.w.F.
1982
Oncology 39:38-«1
(SEXT PSGE)
-------
Hagnesiui
7M9-95-1
At« 21.305, HP 651 C. BP 1100 C, 7P 1 in Bg at 621 c, 10 «a Hq at 740 C
(CONTINUES)
TISSUE
6509
tone
6510
Heart
6511
Intestine
EXPOSURE BOU1E
ANALYTICAL
HETHOD
ES
ES
ES
NUB3EB
OF CASES
5
a) 8
b) 2
c) 3
3) 1
e) 1
10
EA11GE
g
a) Sot given
b) 520-1300 pp»
c) 350—1000 PPB
d) Hot applicable
e) Not applicable
Dry »t
Not given
HEAN
wt
a) 930 +or- 370 ppm
b) 910 ppi
4) 460 ppu
e) 240 ppm
Dry wt
670 +or- 210 ppm dry
«t
I GEI1EEAL INFOEBATION
Autopsies
Japan
TONGUE; ZIRCONItJB; ELEHENTS; JAPAN;
ADULTS; AUTOPSIES; ADPENAL GLANDS;
AOETA; BONES; HEABT; INTESTINES;
KIDNEYS; LIVZB; LONGS; LYBPH NODES;
SPLE1H; PAliCfttAS; STOHACH; THIP.OID
GLANDS; TRACHEA; ALOBINUB; BARKffl;
CADBIUB; CALCIUB; CHBOSIUB ; COBALT;
COPPER; IRON; LEAD; BAGNESIDB;
KANGANESE; NSTAIS; BOLYBDENDB;
NICKEL: PHOSPHORDS: POTASSIOB;
SILICON; SIL»ER; SODIDB; STRONTIOB:
TIN; TITANIDfl; 7ANADIUB; ZINC;
BIOACCHBOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
a) Normal men
b) Chromium plating workers
5) Airplane painter
e) stone mason
Autopsies
Japan
TONGUE; ZIECONIUB; ELEBENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEABT; INTESTINES;
KIDNEYS; LITER: LOSGS; LYBPH NODES:
SPLEEN: PANCREAS; STOBACH; THYROID
GLANDS; TRACHEA; ALOBHUB: BARIDH;
CADBIUB; CALCIDfl; CHBOBIUB; COBALT;
COPPER; IRON; LEAD; BAGNESIUB;
BANGANESE; BETALS; BOLYBDENOB;
NICKEL; PHOSPHORUS; POTASS IUH;
SILICON; SIl'Efi; SODIOB; STBOSTIDa;
TIN: TITANIDB; VANADIUH; ZINC;
BIOACCOBULATION; HEALTH HAZAEDS ;
OCCUPATIONAL HAZARDS
Normal tissue
Autopsies
Japan
TONGUE; ZIRCOHIUH; ELEHEVTS; JAPAN;
ADULTS; AUTOPSIES; ADBENAL GLANDS;
AORTA; BONES; HEABT; INTESTINES;
KIDHEYS; LITEB; LOTGS; LYHPH MODES;
SPLEEN; PANCREAS; STOHACH; THYROID
GLAKDS; TRACBEA; 1LOHIIUB; BABIDB;
CAOBIUM; CALCMB; CHEOfllOS; COBALT;
COPPER; IEON; LEAD; BAGNESIDH;
BANGANESE; BETALS; HOLYBDEHUB;
NICKEL; PHOSPHORDS; POTASSIOB;
SILICON; SILTER; SODIDB; STB01CTIOB;
TIN; TITANIOB; VANADIOB; ZINC;
BIOACCUBULATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
REPEEBNCE
1981
Archives of
Environmental Health
36 (»|: 155-165
,
Teraoka, H.
1981
Environmental Health
36(»):155-165
Teraoka, R.
1991
Archives of
Environmental Health
36(l|):155-165
(NEXT PAGE)
-------
magnesium
7139-95-14
flg
At« 21.305, HP 651 C, 3P 1100 C, VP 1 »B Hg at 621 C, 10 im Hg. at 740 C
(CONTINUED)
TISSUE
6512
Kidney
6513
liver
6514
lung
EXPOSDBE BOUTE
iUllTTICXL
METHOD
ES
ES
ES
_
NOB BEE
OF CASES
a) 8
b) 2
C) 3
dl 1
e) 1
a) 9
b| 2
C) 3
4) 1
e} 1
a| 12
b) 2
c) 3
d) 1
e\ 1
SINCE
a) Hot given
b) 530-760 ppn
c) 530-1000 ppm
d) Hot applicable
e} Hot applicable
Dry wt
a) Not given
b( SI 0-830 ppn
c) 570-1100 ppm
d) Sot applicable
e) Hot applicable
Dry wt
a) Hot given
b) 600-630 ppm
c) 420-840 ppm
<1] Hot applicable
e) Hot applicable
Dry wt
a) 670 +or- 140 ppm
670 pp
763 ppn
1) 550 ppm
s) 200 pp
iry wt
a) 690 +or- 160 ppn
b) 720 ppm
c) 807 pptt
d| 390 ppm
e) 160 ppm
Dry wt
720 *or-
615 ppm
650 ppm
620 ppl
300 ppm
y wt
190 ppu
GEHEStl. MFOHfllTIOH
a) Nornal Ben
b) chroiiaB plating workers
c) cbroaate refitting vorkcrs
d) Airplane painter
e) Stone lason
Autopsies
Japan
TOKGOE; 2IRCONIOB; ELEBEHTS; JAPAN;
JDOLTS: AUTOPSIES; 4DBE1IAL SLAItDS;
AOBTA; BONES; BEARTj INTESTIHES;
KID»ETS; L1VEEJ 10HGS; LTBPH NODES;
SPLEEN; PANCREAS; 5TOBACH; THYROID
GLAK0S; TRACHEA; itO»r»n(!; BAEIOS;
CADBIOH; CALCIOB; CHROHIOn; COBALT;
COPPEB; IRON; LEAD; HAGNESIOH;
NAHGANESE; HETALS; nOLTBDENUn;
KICKEL; PHOSPHOROS: POTASSJOd;
SILICON; SILVER; SODIOH; STBONTIon;
TI»; TITANIOB; VANADIDH; ZINC;
BIOACCDBnLATION; HEALTH HAZARDS;
OCCUPATIONAL EAZABDS
a) Normal Ben
b) Chroniav plating workers
c) chronate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
TONGUE; ZI8COH0B: ELEHENTS: JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
kOHTK; BOSES; HEART; ISTESTISES;
HIDNBTS; LIVES; LDSGS; ITaPH BODES;
SPLEEN; PANCREAS; STOHUCH; THYROID
GLA8DS; TRACHEA; ALOHI«Dn; BARIOB;
CADniun; CAiciDK; cBROHina; COBALT;
COPPEB; IBOH; LBAB; SAGSESIOH;
nANGANESE; KETALS; nOLIBDENDn;
NICKEL; PHOSPHOROS; POTASSIOB;
SILICON; SILVER; SODIDH: SIROBTITO;
TI»; TITASID!!; 7A«ADIff«; ZINC;
BIOACCnMOHTIOS; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
a) Normal flen
b) ClvroniUB plating vockers
c) Chroaate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
TONGUE; ZIRCONIUM; ELEHENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AOBTA; B08ES; HEAET; ISTESTISES;
KIDNEYS; LIVER; LONGS; LYflJH NODES;
SPLEEB; PANCREAS; STOMACH; THYROID
GLANDS; TRACHEA; ALUSISDB; BARIUM;
CADMIUM; CALCIUM; CHROMIUM; COBALT;
COPPER; IBON; LEAD; SAGHESIUS;
MANGANESE; METALS; MOLYBDENUM;
NICKEL; PHOSPHOBDS; POTASSIUM;
SILICON: SILVER: SODIUM; S1BONTIUB;
TIN; TITANIUM; VANADIUB; ZINC;
BIOACCUSOLATION: HEALTH HAZABDS;
OCCOPATIOSAI. HAZARDS
(NEXT PAGE)
Teraoka, H.
1981
Archires of
EnvironBental Health
36(4) : 155-165
Teraoka, H.
1981
Archives of
Environaental
36(4) : 155-165
Teraoka, H.
1981
Archives of
Environaental Health
36(4) :155-165
-------
Hagnesiuo
7139-95-14
"5
AtW 2«. 305, HP 651 C, BP 1100 c, IP 1 mm Hg at 621 C, 10 mo Hq at 740 C
(COST IKIJ ED)
TISSUE
6515
Lyiph
node
6516
Pancreas
6517
Spleen
EKPOSOKE EOOTE
_
ANALYTICAL
METHOD
ES
ES
ES
8 DM BEE
or CASES
a) 3
bl 1
c) 3
a) i
e) 1
a) 9
b| 2
c) 3
3) 1
e) 1
BANGE
a) Not given
b) Sot applicable
c) 530- 1 100 ppm
d) Not applicable
e) Not applicable
Dry wt
Not given
a) Not given
b) 820-860 ppm
c) 400-1300 ppm
d) Not applicable
e) Not applicable
Dry wt
MEAN
a) 1200 +or- 480 ppm
b) 700 ppoi
c) 770 ppm
3) 760 ppm
e) 530 ppm
Dry wt
430 +or- 99 ppm dry
wt
a) 730 +or- 170 ppm
b) 840 ppm
c) 733 ppm
d) 710 ppm
e) 230 ppm
Dry wt
GENERAL IHFORHATIOB
a) Normal aen
b) Chromium plating worker
c) Chronate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
TOHGOE; ZIRCOHIUH; EtEHENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AOPTA; BONES; HEART; INTESTINES;
KIDNEYS; LIVEE; LONGS; LfflPH SODES;
SPLEEN; PANCREAS; STOHACH; THYROID
GLANDS; TRACHEA; ALUHINUfl; BARIUM;
CADMIUM; CALCIUM; CHROMIUM; COBALT;
COPPER; IRON; LEAD; HAGNESIUM;
MASGAHESE; SETALS; HOLIBDEHUR;
NICKEL; PHOSPHORUS; POTASSIOH;
SILICON; SILVER; SODIUM; STRONTIUM;
TIN; TITANIUM; VAHADIDH; ZINC;
BIOACCUHULATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
Noraal tissue
Autopsies
Japan
TONGOE; ZIRCONIOH; ELEMENTS; JAPAN;
A DOLTS; AOTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEART; INTESTINES;
KIDNEYS; LIVER; LONGS; LTBPH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLANDS; TRACHEA; ALOBINOB; BARIOB;
CADBIOB; CALCIOB; CHEOBIOB; COBALT;
COPPER: IRON; LEAD; BAGNESIOB;
BANGANESE; BETALS; BOLYBDENOB;
NICKEL; PHOSPH080S; POTASSItJB;
SIIICOH; SILVER; SOBIOli; S1IOHTKJS;
TIN; TITANIOB; 7ANADIOB; ZINC;
BIOACCOHOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
a) Nornal aen
b) chroniuH plating workers
c) chronate refining workers
d) Airplane painter
e) Stone lason
Autopsies
Japan
TONGOE; ZIRCONIUM; ELESENTS; JAPAN;
ADOLTS; AOTOPSIES; ADRENAL GLANDS;
AORTA; BONE5; HEART; INTESTINES;
KIDNEYS; LITER; LONGS; LYBPH NODES;
SPLEEN; PANCREAS; STOMACH; THYROID
GLANDS; TRACHEA; ALOBINOB; BARIOB;
CADMIUM; CALCIUM; CHROHIOB; COBALT;
COPPER; IRON; LEAD; BAGNESIOB;
SASGASESE; BETALS; BOLIBOEB3B;
NICKEL; PHOSPHORUS; POTASSIUM;
SILICON; SILVER; SODIUH; STRONTIOH;
UN; TITANIUM; VANADIOB; ZINC;
BIOACCOHDLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
-
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
Teraoka, H.
1981
Archives of
36 (H): 155-165
Teraoka, H.
1981
Archives of
Environnental Health
36(»): 155-165
..
(NEXT PAGE)
K>
-------
Hagnesiun
7139-95-1
flg
AtW 20.305, HP. 651 C, BP 1100 C, If 1 mm Eg at 621 C, 10 •> Hg at 740 C
(CONTINUED)
TISSOE
6518
Stonach
6519
Thyroid
gland
6520
Tongue
EXEOSOBE POOTE
A8ALYTICAL
METHOD
SS
ES
ES
HOB BEE
OF CASES
10
tl
2
EASGE
Hot given
_ .
Hot given
Not given
{BEIT
BEAM
670 +or- i10 ppin dry
wt
390 +or- 99 ppm dry
wt
wt
PAGE)
GENERAL iirroRaATios
Nornal tissue
Autopsies
Japan
TONGUE; ZIBCOHIU9: ELEHENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AOBTA: BOHES; HEART; IBTESTIHES;
KIDNEYS; H»ER; LOUGS; LIHPB HODES;
SP1EES; PANCREAS: STOBACH; TBIEOID
SLANCS; TS1CHEA; ALUHIHrin; B1RII7H;
CADBIOH; ciician; cHRoainn; COBALT;
COPPER; IROH; LEAD; aAG»ESItlB;
BAHGAMESE; BETALS; HOLTBDEROB;
HICKEL; PHOSPHOBOS; POTASSIOB;
SILICOH; SILVER; SODIOB; STROHTION;
TIH; TITANIOB; VANtDiaB; ZI»C;
BIOACCDBBLATIOH; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
Hartal tissue
Autopsies
Japan
TOSG01; ZISCOHiaB; ELEMEHTS; JAPAN;
ADDITS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BOBES; HEART; INTESTINES;
KIDNEYS; LI7ER; LONGS; LYBPH NODES;
SPLEEN; PABCEEAS; STOHACH; THYROID
GLANDS; TRACHEA; AlOBINUfl; BARIOB;
CADBI3B: CALCIOB; CHROHIOB; COBALT;
COPPEB; IROH; LEAD; BAGNESID!!;
BANGANESE; HETALS; SOLYBDEtiOf;
NICKEL; PHOSPHORUS; POTASSIOB;
SILICON; SILVER; SODIOH: STRO»TIO»;
TIN; TITAN10B; VANADIDB; ZINC;
BIOACCOaOLJlTIOB; HBA1TH HAZARDS;
OCCOPATIONAL HAZARDS
Autopsies
Japan
TONGOE; ZHCONIOH; ELEBENTS; JAPAN;
ADULTS; AUTOPSIES: ADRENAL GLANDS;
AORTA; BONES; HEART; INTESTINES;
KIDNEYS; LIVER; LONGS; LYBPH NODES;
SPLEEN; PANCREAS: STOBACH; THYROID
GLANDS; TBACHEA; ALOSISffB; BARIOB;
CADBIOB; CHLCIBB; CHBO»IOB; COBALT:
COPPER; IRON; LEAD; BAGNESIUB;
BANGANESE; BETALS; BOLYBDENOB;
NICKEL; PHOSPHORUS; POTASSIOH;
SILICON; SILVER; SODIOB; STRONTIDB;
TIN; TITANIOB; VANADIOB; ZINC;
BIOACCUBOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZABDS
REFERENCE |
Tecaoka, H.
1981
Archives of
Environieutal Health
36(1) :155-165
Teraoka, B.
1981
Archives of
36(1) : 155-165
1981
Archives of
36(1) : 155-165
-------
Nagnesiun
7139-95-4
»9
AtU 2H. 305, BP 651 C, BP 1100 C, VP 1 it Hg at 621 C, 10 11 Hg at 740 C
(COHTIHUED)
TISSUE
6521
Trachea
6522
Urine
EXPOSUEE BOUTE
Ingestion
ANALYTICAL
BETHOD
ES
A AS
HOB BEE
OF CASES
2
2
BADGE
iven
_
a) Not given
b) Not given
c) Hot given
d) Hot given
BEAN
wt
a) 170 »or- 6.9 »g/21
hr
b) 210 »or- 10.5
sg/21 hr
c) 185 »or- K.U «g/24
hr
d) 235 *or- 6.9 mg/24
hr
GESEBAL IBFOBBATIOH
Autopsies
Japan
TONGOF,; zlBcomaa; ELESEMTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AOOTA; BONES; BEAST; IHTESTIHES;
KIDHBIS; H»EE; LONGS; LrBPH HODES;
SPLEE»; PANCREAS; SIOBACH; TBTBOID
GLANDS; TBACBEA; ALOBIIUB; BABIDB:
CADBIOB; CALCIUM; CHROBICJB; COBALT;
COPPER; IBOII; LEAD; BAGHESIOB;
BANSAMESE; BETALS; BOLYBDENOB;
BICKEL; PBOSPHOBOS; POTASSIOB:
SILICON; SILVEB; SODIDB; STBODTIDB;
Tin: TITAHIOM; TiHADIOB; ZIBC:
BIOACCUBDLATIOII; HEALTH HAZARDS;
OCCDPATIO«AL BAZ ABDS
a) Subject 1, intake 318 >g/2U hr.
lov fiber diet
b) Subject 1, intake 650 ig/24 hr.
high fiber diet
c| Subject 2, intake 380 •g/ZI hr.
low fiber diet
d) Subject 2, intake 72« ig/20 hr.
high fiber diet
Total dietary intake
Beans of 10 2-day periods
SOT caloric intake from white bread
in a) and c) , and f ton high fiber.
loderate phytate, local bread in b)
and d)
Both subjects in negative balance on
high fiber diet.
35 and 28 yr old, lit 56.0 6 60.3 kg.
Iran
IBAB; ADULTS; SOTBITIONUL
DEFICIENCIES; BLOOD PLASflA; BLOOD
SEBUB; URINE; CALCIOB; HAGHESIUH;
EHOSPHOBOS; ZIHC; DIETS; FIBERS;
FOODS; BETALS
Teraoka, B.
1981
Archives of
BnvironBental Bealth
36(4) : 155-165
Beinhold, J.G.
Faradji, B.
Abadi. P.
Isiail-Beigi, F.
1976
Journal of Nutrition
106:093-503
-------
Manganese
7K39-96-5
AtV 54.9380, HP 1244 C, BP 2095 C. VP 1 •• Bg at 1292 C, 10 •• Hg at 1510 C
TISSUE
6523
aland
"
plasma
6526
Elood,
EXPOSURE ROOTE
AKALVTICiL
BETHOD
ES
ES
ins
AAS
I OH BEE
OF CASES
7
7
a) 26
c) 52
d| 11
e) 10
f) 21
g| 10
h) 10
BADGE
Hot given
Hot given
a) Hot given
b) Not given
a) Mot give
c) Hot give
d) Hot give
e) Sot give
It Hot give
g) Hot give
h) Hot give
(HEII
HEAN
0.79 +or- 0.11 ppa
dry vt
0.39 *or- 0.06 ppm
dry «t
a) 0.011-0.078 ujuxL/l
b) 0.023 +or- 0.01
uaiol/1
a) 0.007 «or- 0.001
b) 0.009 *or- 0.002
?PH
c) 0.008 *or- 0.002
PP»
d) 0.006 *or- 0.002
ppm
ppn
f) 0.011 »or- 0.004
ppn
g) 0.007 *or- 0.001
PP»
h) 0.008 »or- 0.001
pp.
i) 0.007 toe- 0.005
PP»
PAGE)
GEIERAL WFOEnHTIOd
formal tissue
Aatopsies
Japan
JAPiH; AODLTS; AUTOPSIES; ADREIAL
GLJUDS: AOBTA: BOBES; HEART;
IHTBSTIHES; KIDMETS ; LITBE; LOfGS;
ITBPH NODES; PtMCBEAS; SPLEEH;
STOBACH; THTSOID GIABDS; TRACHEA;
ALDIIIRDK; BIBing; CADnltJfl; ctLCIOH;
CHROHIOB; COBALT; COPPER; IROB; LEAD;
HAGHESIOII; flSBGAHESE; HETA1S;
BOLTBDENO!!; KICKEL; PHOSPHOBDS;
POUSSIDH; SILICO»; SIITER; SODinS;
sTBominii; Tin; TITAITIBB; VAHADIOB;
ZIRC; BIOiCCOBDLATIOB; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOHGOE: ZIBCOBIOB: ELESEHTS
Horaal tissae
Autopsies
JAPAN; AOOI.TS; AUTOPSIES; ADRESAI.
GIAHDS; AORTA; BOHES; HEART;
IHTBSTISES; KIDXErS; LI'EB; LffUGS;
ITHPH KODES; PAHCREiS; SPLEEH;
STOBACB; THTBOID GLA»DS; TBACHEA;
ALOflHUB; BAHIOfl; C4DBIDM; CALCID8;
CHBOHIOB; COBALT; COPPER; IBOH; LEAD;
BAG1ESIUB; HANGAHESE; BETALS;
BOLIBDEHOIf; NICKEL; PHOSPHOBOSr
POTASSIDfl; SILICON: SIIJEB; SODIUH;
SIBOHTTOH; TI»; TITABIOB; »A!"ADIOB;
ZMC; BIOACCOBOLATIOH; HEALTH
HAZARDS; OCCOPATIOHAL HAZARDS;
TONGOE: ZIRCONIUH; ELEHEXTS
a) Healtbf controls
b) 36 patients with acute ayocardial
infarction
BLOOD PLASHA; CARDIOVASCULAR
DISEASES; HEART DISEASES; COPPER;
BAGNESIOB; MAHGAKESE; ZINC
a) Lang and respiratory tract
c) Breast
4) Cer»ii
e) Lyiphatic leukeiia
f) nalignant >elano«as
g) Rodgkin*s lyaphona
h) Healthy volunteers
a) ~9) type of cancer
Ho significant difference between
controls and cancer patients
Cancer patients (15-81 yr olds) ,
geriatric patients (65-81 yr olds).
healthy volunteers (20-U& yr olds) ,
Olt
UHTTED KIHGDOB: CARCIHOHAS : LEOKESIA;
KELAKOHAS; KEOPLASHS; SABCOnAS; BLOOD
SEROB; CALCIDB; COPPEP ; BAGHESIUB;
BAIIGAHESI; BETALS: ZHC:
BIOHDICATOBS
HEFERESCE
-
Teraofca, B.
1981
Archives of
Environmental Health
36(1): 155-165
Teraoka, H.
1981
Archives of
36(4): 155-165
Zuikley. B.
Bertram, a. p.
Tetter, H.
Tank, B.
Birth, ».
1980
Trace Substances in
VI?, D.D. Heiphill, ed.
pp 211-216
Capel, I.D.
"illia.s. D.C.
Hanhai, I.e.F.
1982
Oncology 39:38-41
-------
Manganese
71439-96-5
tin
At« 54.9380,
HP 1244 C, BP 2095 C, vp 1 urn Hg at 1292 C, 10 •• Hg at 1510 C
(CONTINUED)
TISSUE
6527
Bone
6528
Hair
6529
Hair
6530
Hair
EXPOSURE SOUTE
ANALYTICAL
BETHOD
ES
HA
SA
NA
S OR BEE
OF CASES
5
56
59
BINGE
Hot given
0.062X10 (E-6)-43. 14X10(E-
6) g/cu CB
2-3.7 ng/g
a) 0.2-19.8 ppa
b) 0.08-13.6 pp>
cl 0.2-17.2 ppa
4) 0.2-7.5 ppn
<2.0 pp« dry lit
0.829I10(E-6) g/cu cm
Not given
a) 4.21 +oc- 3.66 ppm
D) 3. 9 *or- 3.5 pp»
c) -6.5 +oc- 4,1 ppa
d) 3.2 +oc- 1.8 ppin
GENERAL INFOBBATION
Nornal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
SLANDS; AOETA; BONES; HEART;
INTESTINES: KIOHEYS; LIVEE; LONGS;
L1HPH HODIE; PADCBEAS; SPLEES;
SIOBACB; THIEOID CLAUDS; TBACHEA;
ALOni»U«; BAEIDH; CADHIDH; CA1CIOB;
CHEOBIOB; COBALT; COPPEB; IBOM; LEAD;
BUGNESIOS; BAIGANESE; HETALS;
(lOLTBDEHaB; NICKEL; PHOSPHOBOS;
POTASSIBB; SILICON; SILVEB; SODIOS;
SISONTI0H; til; TITASIOH; VANADinB;
ZINC: BIOACCOBOLATIOK; HEALTH
HAZARDS; OCCUPATIONAL HAZAEDS;
TONGUE; ZIBCONIOB; ELEBENTS
3 CB segments of single hairs
Sore sa&ples beiou detection liaits
IEIDIOB; HAIB; FORENSIC SEDICINE;
HEASOREBEHT BETHODS; ANTIBOST;
AESENIC; BBOBINE; COPPER; GOLD;
LAKTHSNON; BANGANESE; BEECOET;
BETALS; SELERIDB; SILTEB; SODIOB;
SIFONTinB; zmc; INDOSTEIAL
ATMOSPHERES
Bange of leans, estiuted fcoi graph
Aswan, El Knarga, Assait* Cairo, and
Alexandria, Egypt
EGIPT; HAIR; NAILS; ANTIBONI;
CADBIUB; CESIOB; CHBOBIOB; COBALT;
IBON; BANGANESE; BETALS; BOLTBDE8DB;
SCANDIOB; SILENIUB; SILTEB; TDNGSTEN;
ZI»C; DBIK1UNG »ATEE; POPULATION
EXPOSOBE; SOILS; tJEBAN ABEAS
a) 12 en length, 103 saiples
b) Boot section, 18 samples
c) Distal section, IB sanples
d) -Students in a), 26 sattples
Levels in people near fossil fuel
povec station tvice those froi other
areas.
Betcopolitan Boibay, India
IHDIA; ADOLESCENTS: ADULTS; HAIR;
ANTinONT; ABSENIC; BBOBINE; CAOBIUB;
CHLOEISE; CBEOBIoa; COBALT; COPPEE;
GOLD: IODINE: IBON; LANTRANUB;
BANSAHESE; POTASSIDH; SCANDIDB;
SELENIOB; SILTEB; SODIUN; ZINC; AIB
POLLUTION; BIOACCOflOUTIOH: FOSSIL
FUELED POREB PLANTS; INDOSTBIAL
ABEAS; INDOSTBIAL ATBOSPBEBES;
IHDOSTEIAL ESISSIOSS; IHOtlSTBIAL
EOLLDTION; POPULATION ETPOSDBE; URBAN
ABEAS; INDUSTRIAL CHJHICALS
Teraoka, H.
1981
Archives of
Environaental Health
36(1) :155-165
Dybczynski, B.
Boboli, K.
1976
Journal of
Badioanalvtical
Chemistry 31:267-289
ON
Kasperek, K.
lyengar, 6.7.
Feinendegen, L.E.
Hashish, 5.
Bahfouz, B.
1982
Science of the Total
Environnent 22:149-168
Bhat, K.B.
Acunachalaa, J.
Tegnasabcamanian, 5.
Gangadharan, S.
1982
science of the Total
Environment 22:169-178
(NEXT PAGE)
-------
Manganese
7H39-96-5
Bn
At» 511.9380, HP 1241 C, BP 2095 C, VP 1
Bg at 1292 C, 10
Hg at 1510 C
(CONTIBOED)
TISSDE
6531
8air
6532
Heart
Intestine
EXPOSURE RODTE
ANALYTICAL
BETHOD
AAS
ES
NOB BEE
OF CASES
3
a) 8
b) 2
c| 3
d) 1
RANGE
a) Hot given
b) Hot given
d) Sot given
e) Hot given
a) Hot given
b) 0.73-2.9 ppn
c) 1.0-2.9 ppn
e) Bat applicable
Dry »t
flEAN
a) 3.89 ug/g
b) 2.70 ug/g
d) 1. 16 ug/g
e) 1.83 ug/g
a) 0.67 *or- 0.27 ppm
b) 1.6 PPB
0) 1.8 ppa
e] 0.51 ppo
Dry »t
wt
GENEEAL I» FORMATION
a) Subject 1, unwashed hair
J>) Subject 1, after 12 successive
c) Subject 2, unwashed hair
d) Subject 2, after 12 successive
e) Subject 3, unwashed hair
f) Subject 3, after 12 successive
washes in sodium lauryl sulfate
a) , c) e) , 6-10 determinations, each
subject. Data also for other
procedures and washing agents.
BAIR; COBPABATIVE EVALOATIOBS;
CADRIDH; COPPER; IEON; HABGABESE;
ZINC
a) Normal health? men
b) Chromium plating workers
c) Chromate refining workers
e) Stone mason
Autopsies
Japan
JAPAB; ADOLTS: AOTOPSIES; ADRENAL
GLANDS; AORTA; BOBES; HEART;
INTESTINES; KIDNEYS; LITER; LOBGS;
LYBPH BODES: PANCREAS; SPLEEN; -
STOBACH; THYROID GLABDS; TRACHEA:
ALtJBINOB; BARIOB; CADHIOB; CALCItJS;
CBEOBIOB; COBALT; COPPER; I50B; LEAD;
HAGBESIOB; BABGABESE; BETA IS;
fCLYBDEBOB; NICKEL; PHOSPHOROS;
POTASSIOS: SILICOB; SILVER; SODIHB;
STRONTIOH; TIS; TIHSIOH; VABADI1B;
ZINC; BIOACCD»!IL»TION; HEALTH
HAZARDS; OCCOPATIONAL HAZARDS;
TONGOE; ZIRCONIOB; ELEMENTS
Autopsies
JAPAN; ADOLTS; AOTOPSIES: ADBINAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LOBGS;
LYBPH BODES; PANCREAS; SPLEEN;
SIOSACH; THYROID GLANDS; TBACHEA;
ALOHINOI): BARIOB; CADBIOH; CALCIUB;
CBROBIOfl; COBALT; COPPER; IRON; LEAD;
BAGNESIOn; BABGANESE; BETALS;
BOLYBDE1SOH-, HICKIL; PHOSPHOROS;
POTASSIUS; SILICON; SILVER; SODIOB ;
S1BONTIOB; TIB; TITABIOB; VANADIDH;
ZINC; BIOACCOHOLATIOB; HEALTH
HAZARDS; OCCUPATION JL HAZARDS;
TOBGDE; ZIECONIOfl; ELEHENTS
. _.._..
BEFERESCE
- -
Salmela. S.
Vuori, E.
1981
Analytica Chiiica Acta
Teraolca, H.
1981
Archives of
36(4) : 155-165
1981
Archives of
36(0) .-155-165
(NEXT PAGE)
-------
Hanganese
7139-96-5
flu
AtW 54.9380. HP 1244 C, BP 2095 C, VP 1 ni Hg at 1292 C, 10 •• Hg at 1510 C
(CONTINUED)
6534
Kidney
6535
Liver
6536
Liver
EXPOSURE BOOTE
ANALYTICAL
flETHOD
S OB BEE
OF CASES
a) 8
D) 2
C) 3
d) 1
el 1
a) 9
o) 2
c) 3
d) 1
e) 1
30
BADGE
a) Hot given
b) 0. 95-4.il ppi
c) 1. 1-3.3 pp>
d) Not applicable
e) Hot applicable
Dry wt
a) Hot given
b) 2.3-7.6 ppM
c) 3.0-14.6 pp»
4) Hot applicable
e) Not applicable
Dry wt
0.5-1.9 ug/g
Wet vt
SEAS
a) 1.5 +or- 0.67 ppm
b) 2.7 pp«
c) 2.0 ppm
d) 0.90 ppn
e) 0.64 ppn
Dry wt
a) 4.4 *or- 1.8 ppm
b) 5.0 ppn
c) 3.8 pp»
d) 2. 1 PPM
e) 0.69 pp>
Dry vt
Not given
GENERAL IHFOSBATIOH
a) Normal healthy men
b) Chromium plating workers
c) Chroaate refining workers
d) Airplane painter
e) Stone Bason
autopsies
Japan
JIP1H; ADULTS; AUTOPSIES; ADREHM.
GLARDS; AORTA; BONES; HFAET;
IHTESTIHES; KIDHEIS; IIVER; LOUSS;
IYBP1 HODES; PABCBEAS: SPLEEN;
STOHACH; TBIROID GLANDS; TEACHEA;
ALBBI«ai!; BABIOD; CiDBIUH; CilCHJB;
CBEOnlDn; COBALT: COPPER; IRON; LEAD;
KAGNESIO)!; MANGANESE; METALS;
BOLIBDENOn; NICKEL; PHOSPHORUS;
POTASSIOB; SILICON; SILVER; SODIOH;
STRONTIOB; TIN: TITANIO!!; VANADIOB;
ZINC; BIOACCnBOLATION; HEALTB
HAZARDS; OCCOPATIOKAL BAZARD5;
TOHGDEJ ZIRCONIUM; ELEMENTS
a) Normal healthy men
b) chroniua plating Horkers
c) chroaate refining workers
d) Airplane painter
e) s tone lason
Autopsies
Japan
JAPAN; ADDLTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEART;
INTESTISES; 1CTONEIS; LITER; LONGS;
LY.B5H SODES: PANCREAS; SPLEZ»;
STOBACH; THIROID GLANDS; TRACHEA;
ALOHINOn; BASIOK; CADHIDB; CALCIOM;
CBROBIOB; COBALT; COPPER; IRON; LEAD;
MAGNESIUM; MANGANESE; METALS;
BOLTBDENDH; NICKEL; PBOSPBORDS;
POTASSIOB; SILICON; SILVER; SODIOB;
sisoNTinn; TIN: iiTANinii: VANADIOB;
ZINC; BIOACCOgOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIBCONIOM; ELEHENTS
Category 1 (first priority element)
as proposed by International Horkshop
on Monitoring Environmental Materials
and Specimen Banking
Autopsies, Baltiiore, MD,
Minneapolis. MN, and Seattle, IA
HAETLAND; nlRNESOIA; WASHINGTON:
ADTOPSIES; LIVER; HEASOREflEBT
BFTBODS; ALOKIliaB: i»TI»0»I; AES5NIC;
IAEIDB; CJDBIOM; CHBOI1HJH; COBALT;
COPPER; FLUORINE; IEON; LEAD;
BANGANESE; MERCORI; BOLTBDENDB;
NICKEL; RHBIDI0B; SELENIOB; SILVER;
STRORTIDB; TBALLIDM; TIN; VANADIUM;
ZINC; POPULATION EXPOSURE
DEFERENCE
Teraoka, H.
198)
Archives of
Environmental Healta
36(4): 155-165
Teraoka, B.
1981
Archives of
Environmental Health
36(4): 155-165
OO
Harrison, S.B.
Zeisler, R.
wise, S.A.
1981
EPA 600/S1-81-025. 6
pp.
(NEXT PAGE)
-------
Manganese
7"4 39-96-5
tin
Atw 50.9380. HP 124» C, BP 2095 C, IP 1 «» Hg at 1292 c, 10 BB Hg at 1510 C
(CONTINUED)
TISSUE
6537
Lung
6538
Lypph
node
Hail
EXPOSURE BOUTE
ANALYTICAL
BETHOD
ES
ES
» OH DEB
or CASES
a) 12
>>) 2
c) 3
e) 1
a) 3
b) 1
c) 3
e) t
RANGE
a) Hot given
b) 1.7-1.2 pp«
C) 1.3-18 pp«
e) Hot applicable
Dry wt
a) Hot given
b) Hot applicable
o) 2.4-11 pp«
e) Sot applicable
Dry wt
HEAD
a) 1.1 *or- 0.53 ppm
b) 2.9 ppa
c| 7.t ppB
e) 3.9 ppu
Dry wt
a) 7.5 *or- 3.9 ppn
b) 1.9 ppa
c) 5.6 ppB
e| 3.3 ppu
Dry wt
GEN1BAL IKFOfiBATIOS
a) NorBal healthy men
b) ChroaiUB plating workers
c) Chcomate refining vorkeci-
e) Stone lason
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADRENAL
GIANDS; AOSTA; BODES; HEABT;
IHTESTIHES; KIDSEIS; LITEB; LOKGS;
1TIPR KODES; PAKCEEAS; SPLEEH;
STOHACH; THISOID GIASDS; TB1CHEA;
ALnnmnn: BAEIOM; CAoninn; CAtcinn;
CBROniOB; COBALT; COPPER; IRON; LEAD;
HAGIESIOH; BANGANESE; METALS;
nOLYBDEHUH; BICKEL; PHOSPHOEOS:
POTASSIOB; SILICON; SILVER: SODHJS;
STBOHKDH; TIK; TITASIOB; Tm»Dia»;
ZIKC; BIOACCOBOL1TIOR; HEALTH
HAZAHD5; OCCOPJTIOK1L HJZABDS;
TOMGOE; ZIBCOBIOB; ELEBEBTS
a) Nornal healthy >«Q
b) chrOBini plating worker
c) Chronate refining workers
e) stone Bason
Auttfpsies
Japan
JAPAN; ADULTS; AUTOPSIES; JDBEHAL
GLANDS; AOBTA; BONES; BEAUT;
INTESTINES; KIDNEYS; LIVEB; LUNGS;
LYHPH BODES; PANCREAS; SPLEEN;
STOJIACH; THYROID GLANDS; TRACHEA;
ALUBINOB; B4BIOB; CADHIUH; CALCIOB;
CBBOniUB; COBALT; COPPER; IRON; LEAD;
KAGBESIUB; BANGANESE; KETALS;
HOLIBDENUB; NICKEL; PHOSPHORUS;
POTASSIOD; SILICON; SILVER; SODIUB:
STBONTIOH; TIK; TITANIOB; VJNADIUS;
ZINC; BIOACCOBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TONGUE; ZIRCONIUB; ELEBENTS
saBples £roB 5 Egyptian cities fro»
Aswan to Alexandria
Aswan, El Kharga, Assnit, Cairo, and
Alexandria, Egypt
EGYP'; HAIB; NAILS; ANTIBONY:
CiDBIUB; CESIUH; CHROBIUH; COBALT;
IRON; HANGAHESE; BETALS; BOLYBDENU 1!;
SCABDIOH; SELEBIUH; SILVEfi; TUBGSTE8;
ZINC; DRINKING WATER; POPULATION
EXPOSURE; SOILS; ORBiN »8J AS
_
DEFERENCE
Teraoka, H.
1981
Archives of
36 (»): 155-165
Teraoka, H.
1981
Archives of
36(1) : 155-165
lyengar, G.v.
Feinendegea, L.E.
Hashish, S.
Bahfouz, B.
1982
Science of the Total
Environment 22:119-168
(NEXT PAbE)
-------
Hanganese
H439-96-5
flu
At» 54.9380,
HP 1244 C, BP 2095 C, VP 1 mm Hg at 1292 C, 10 in Hg at 1510 C
(CONTINUED)
TISSUE
6540
Pancreas
6541
Spleen
65'I2
Stomach
EXPOSURE EODTE
ANALYTICAL
METHOD
ES
ts
SS
SOBBEB
OF CASES
5
a) 9
W 2
0) 3
d) 1
e) 1
10
BANGE
Hot given
a) Hot given
b) 0.82-5.5 ppm
o| 1.3-4.2 ppm
d) Hot appiicable
e) Hot applicable
Dry «t
Hot given
(NEXT
HEAH
1.6 tor- 0.47 pp« dry
wt
a) 1.3 +or- 0.75 ppm
b) 3.2 pp«
c) 3.1 ppm
d) 1.7 ppm
e) 1.3 ppm
Dry v t
1.1 +or- 0.47 ppm dry
wt
PAGE)
GENBBAL INFOBBATION
Normal tissue
Autopsies
Japan
JAFAS; ADDITS; AOTOPSIES; ADBEHAL
CLAUDS; AOETA; BONES; HE»BT;
INTESTINES; KIDBBTS; LIVEE ; IOHGSJ
ITBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYEOID GLANDS; TBACHEA;
ALUBUDB; BABIHB; CADBIOB; CALCIDB;
CHEOBIUB; COBALT; COPPEB; IBON; LEAD:
BAGNESIOB; BAHGANESE; BETALS;
BOLIBDENOB; NICKEL; PHOSPHORUS;
poTsssina; SILICOS; SILVER; SODIHB;
STSONTIOB; UK; IHAMintl; VAHADIOn;
ZINC; BIOACCOBOLJTION; HEALTH
HIZAEDS; OCCUPATIONAL HAZABDS;
TOUGH!; ZIECONIUfl; ELEBENTS
a) Normal healthy men
b) chromium plating workers
c) Chcomate refining vockecs
,d) Airplane painter
e} Stone mason
Autopsies
Japan
3APAN; UDDLTS; AOTOP3IES; APBBHAL
GLANDS; AORTt: BONGS; HEABI;
INTESTINES: KIDNEIS; LIVBB; LONGS;
IIBPR NODES; PANCBEAS; SPLEEN;
STOBACH; THtBOID GLANDS; TEACHEA;
SLOBIBnn; BARIDB; CADBIDB; CALCIOB;
CHBOBIOM: COBALT; COPPEB; IBOB! LEAD;
BAGNESIDB; IIASGHNESE; BETALS;
fOLTBBENOB; NICKEL; PBOSPHOBOS;
EOT1SSIDB; SILICON; SILVEB; SODIOB;
STBONTIOB; TIB; TITANIHB; VANADIOB;
ZINC: BioAccoanLAiioN; HEALTH
RAZABDS; OCCUPATIONAL HAZABDS;
TONGDE; ZIBCONIOB; ELEMENTS
Normal tissue
Autopsies
Japan
JAFSN; ADOLTS; AOTOPSIES; ADBEBAL
GLANDS; AOBTA; BONES; BESET;
INTESTINES; ItlDHEIS; LIVES; LONGS;
LTBPH NODES; PANCBEAS; SPLEEN;
STOBACH; IHTBOID GLANDS; TEACHEA;
ALOBIKOB; BABIOB; CADBIOB; CALCIOB;
CHBOBinS; COBALT; COPPEK; IBON; LEAD;
.IAGRESIOH; OABGASESE; BETALS;
BOLIBDENOB; NICKEL; PHOSPHOBOS;
POTASSIOB; SILICON: SILVEB; SODIOB;
STEONTIOB; TIB; TITANIOB; VANADIOB;
ZINC; BIOACCDBOL1TION; HEALTH
RAZABDS; OCCUPATIONAL RAZABDS;
TONGDE; ZIBCONIDB; ELBHEBTF
Teraoka, H.
1981
Archives of
Environmental Healta
36(4):155-165
Teraoka, H*
1981
&ccbives of
environmental. Health
36(4); 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36<»):155-165
-------
flanganese
7U39-96-5
HJJ
At» 50.9380, BP 12»« C, BP 2095 C, ?P 1 «J Hg at 1292 C, 10
Hg at 1510 C
(CONTINUED)
TISSUE
6543
Thyroid
gland
6544
Tongue
Trachea
EXPOS08E ROUTE
ANALYTICAL
9ETHOD
ES
ES
N OB BEE
OF CASES
4
2
2
SANGE
Not given
Not given
§
BEAN
0.44 tor- 0.11 ppm
dry vt
0.43 tor- 0.06 pp»
dry wt
dry vt
GENERAL INFOEHATION
Nona! tissue
Aatopsies
Japan
JAPAN; ADOtts; AUTOPSIES; AOBEHAt
GLANDS; AORTA: BONES; BEAE1;
INTESTINES; KIDNEYS; LI7EH; LONGS;
LYKPH NODES; PANCREAS; SPLEEN;
STOBACH: THYEOID GLANDS; TBACHEA:
ALOBINOH; BARIUS; CADBIUB; CALCIOB;
CHROBIOB; COBALT; COPPER: IRON; LEAD;
BAGNESIUB; HANGANESE; HETALS;
HOLYBDENOH; NICKEL; PHOSPHOBOS;
POTASSIUB; SILICON; SILVER; SODIUB ;
STRONTItW: TIN; TITlNinU; VASADIUf!;
ZINC; BIOACCOHULATION; HEALTH
HAZABDS; OCCUPATIONAL HAZABDS;
TONGOE; ZISCONIUB; ELEHFNTS
Norial tissue
Autopsies
Japan
JAPAN; ADOLTS; AOTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES: KIDNEYS; LIVES; LOSiS;
IYHPH IIODSS; PANCBBAS; SPLEEN;
ST08ACH; THYBOID GLANDS; TBACHSA;
ALOHINOB; BABIOB; CADBIUB; CALCIUB ;
CBROHIOH; COBALT: COPPER; IRON; LEAD;
HAGNESIOH; 8ANGANESE; HETALS;
HOLYBDENOB; NICKEL; FHOSPHOBOS;
POTASSIOB; SILICON: SILVER: SODIUH;
STRONTIUB; TIN; TITANIUB; VANADIUB;
ZINC; BIOACCUBULATION; HEALTH
HAZARDS; OCCOPATIOKAL HAZABDS;
TONGUE; ZIBCONIUH; ELEMENTS
Autopsies
Japan
JAPAN; ADOLTS; AOTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYHPH NODES; PANCREAS; SPLEEN;
STOBACH: THYEOID GLANDS; TBACHEA;
ALmiINU!!; BABIDB; C1DSIDH; C1LCIOTI;
CBBOnlUB; COBALT: COPPEE; IRON; LEAD;
BAGHESIOB; BANGANESE; BETAIS;
BOLYBDENOB; NICKEL; PHOSPHORUS;
POTASSIOB: SILICON; SILVER; SODIOB;
STBONTIOff: TIN; TITANIOB; VANADIUB;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCOPATIONAL HAZABDS;
TONGOE; ZIRCONIOB; ELEHENTS
1
REPEBESCE
Teraoka, H.
1981
Archives of
36(4) : 155-165
Teraoka, H.
1981
Archives of
Enriron&eatal Health
36 (4): 155-165
Teraoka , H,
1981
Archives of
36(«) : 155-165
-------
Mercury
7139-97-6
Hg
Its 200.59, BP -38.87 c, BP 356.72 C, 7P 2X10(E-3) u Hg at 25 C, 100 BB Hg at 260 C
TISSUE
6546
Blood
65(7
Blood
6548
Blood,
cells
6549
Blood,
cells
EXPOSURE BOOTS
logestion
ANALYTICAL
HETHOD
AAS
GC-EC
GC
(OTBEB
OF CASES
1
23
a) 26
b) 28
a) 28
b) 26
HA USE
Mot applicable
I.»-I7. 6 ug/100 ml
a) Hot given
b) Hot given
a) Hot given
b) Hot given
BEAH
251 ppb
Not given
a| 2.5 tor- 1.8 ng/g
b) i.« tor- 1.2 ng/g
a) 2.5 tor- 1.8 ng/g
b) 1.4 tor- 1.2 ng/g
GENEBAL IHFORBATION
Extrapolated froa hair Hg level
Sub-ject had pica for paper, caused by
F« deficiency. She inadvertently
consuBed 191-341 ppb Hq daily.
46 yr old, Fe-deficient native
(Indian or Inuit) , Canada
eitreBities
CANADA; CASE HISTORIES; HETAL
POISONIHG; HDTRITIOHAL DEFICIENCIES;
ElOOD: BERCOBI: BFIALS; HEALTH
HAZARDS; PICA
cheaical plant workers with average
workplace tiBe 8.25 yr
5-95 percentile range
GERBAHT; ADULTS; BLOOD! OBIHE;
COBPARATIVE EVALUATIONS: HIDOSTRIIL
KECICIHE; ODHIOB; LEAD; HEBCVRT;
HETiLS; PBOTEIHS; HEALTH EAZIRDS;
IRDDSTRIAL P1AHTS; OCCUPATIONAL
HAZARDS; SBELTEBS
a) Baternal saaples
b) Fetal saiples
Significant difference between a) and
b) (p < 0.01). Organic Hg levels
but significantly higher for b) (3.9
tor- 3.0 ng/g). Beither a) nor b)
correlated with placental inorganic
Bq levels
Patients residing in or near
Cleveland, OH
onio; ADULTS: HEHBORK; BLOOD PLASIIA;
EBVTHROCTTES; PLACEHTA; COBP.BATIVE
EULOATIOBS; HEBCOBI IHORGAHIC
COBPOBBDS; BEBCOBI OBGAHIC COBPOOHDS;
BETALS; PBEGDA1ICT; BEBCUBT
a) Maternal erythrocytes
b) Fetal erythrocytes
a) significantly higher than b)
Patients residing in Cleveland, OH.
CRZGHAHCI; KEBCUBY; HEBCOBT IHOBGANIC
COBPODSDS; KETHT1 RADICALS; BLOOD;
PLACEHTA; OHIO; FETUS; BRyTHROCITES
REFERS8CE
olynyk, F.
Sharpe, D.H.
1982
New England Journal of
Medicine
306(17) : 1056- 1057
Schaller, K.H.
Gonzales, J.
Thurauf, J.
Schiele, R.
1960
Zentralblatt fuer
Bakteriologie,
Parasitenkande ,
InfektionskranUieiten
und Hygiene, Abteilung
1. originals, Reihe B.
Hygiene, Preventive
fledizin 171:320-335
Ktthnert, P. H.
Kuhnert, B.6.
Erhard, P.
1981
obstetrics and
Gynecology 139:209-213
Kahnert, P.fl.
Kuhnert, B. B.
Erhard, p.
Prochaska, A.L.
1980
Proceedings, University
of Missouri Annual
Conference on Trace
Substances in
Environaental Health
14:182-188
-
to
(HEZT PAGE)
-------
Mercury
7639-97-6
Bq
AtK 200.59, HP -38.87 C, BP 356.72 C, VP 2X10(8-3) u Hg at 25 C, 100 •> Bg at 260 C
(COHUHOED)
TISSUE
6550
Blood,
6551
6552
Brain
6553
EXPOSURE POOTE
AHA1TTICAL
METHOD
GO EC
HA
AAS
AAS
SOBEEB
OF CASES
a) 22
b) 22
a) 7
b) 5
51
82
BINGE
a) Mot given
b) Mat given
a) <0. 02-0. 10 ppi
b) 0.00-0.096 pp«
a) <5-26 ug/kg
b) <5-22 ug/kg
c) <5-26 ug/kg
d) <5-17 ug/kg
e) <5-17 ug/kg
f| <5-16 ug/kg
g) <5-16 ug/kg
h) <5-14 ug/kg
i) <5-16 ug/kg
a) 1.7-69.9 ug/kg
b) Vat give
c) Not give
d) Mot give
e) Hot give
f) Sot give
g) Hot give
h) Hot given
(HEX!
BEAH
a) 1.7 *or- 1.4 ng/y
b) 2.6 tor- 1 .9 ng/g
a) O.OU5 ppi
b) O.OUO pp>
Medians
a) <5 U9/kg
b) <5 ug/kg
c) 6.3 ug/kg
d) <5 ug/kg
e| <5 ug/kg
f| <5 ug/kg
y) <5 ug/kg
h) <5 ug/kg
i) <5 ug/tg
Median
a) 8.1* *oc- 10.0
ug/kg
b) 6.8 ug/kg
c) 8.2 *or- 9.6 ug/kg
d) 10.7 tor- 16.9
ug/kg
e) 9.3 *or- 8.3 ug/'Kg
f) 9.0 +or- 9.4 ug/kg
g) 4.7 tor- 2.3 ug/Kg
h) 3.2 ug/kg
S.E.
PiGE)
GEHEBAL mFOBBATIOH
a) Maternal saaples
b) Petal samples
Significantly different (p < 0.02)
Both a) and b) significantly greater
than corresponding organic Hg levels
|0.t *or- 0.2 and O.i» *or- 0.3 ng/g.
respectively)
Ho correlation with inorganic Hg
levels in placenta
Patients residing in or near
Cleveland, OB
OHIO; ADULTS; NEVBOBH; BLOOD PLASH1;
IRrTHSOCriBS; PIACBKT1; COHPABAIIVE
EVJLOATIONS; BEECDBT IKORGJNIC
COBPODHDS; PIERCOBY ORGAHIC COHPOOHDS;
METALS; PEEGHASCY; HEECDRI
a) Exposed group
b) controls
Autopsies, feiur
AUTinONy; ARSENIC; CADHIOn; COPPEB;
LI»D; MEBCtTEI; SELEHIOH; SILVER; TIH;
ZI»C; BIOACCnMOLATIOH; IHDOSTBIAL
ATHeSPHEBES; ISDOSTEIAL PLAHTS?
POPDLATIOH EXPOSOBE; S9ELTEBS; BOHES;
FIMOB; COBPAEATIVE EVALDATIOHS;
SWEDES; AUTOPSIES; OCCUPATIONAL
HAZARDS; HETALS
a) Total
b) Men
c) Honen
d) Total
e) Men
£) Hoaeti
g) Total
h) Ben
i) tfomen
Autopsies, Gernany
GEBHAHI; AUTOPSIES; BBAIH; KIDHEYS;
LIVER; ME8CUBY; METALS
a) All sanples
b) 0-9 yr olds, 2 saiples
c) ftO-49 yr olds 6 samples
d) 50-59 yr olds 15 saiples
e) 60-69 yr olds 21 saaples
f) 70-79 yr olds 22 samples
q) 80-89 yr olds 1ft sanples
h) 90-96 yr olds 2 saiples
PostHorteas
Czechoslovakia, 1980
CZECBOSIOVAKIi; ADULTS; AUTOPSIES;
CHILD8EB; HEBBOBB; BLOOD; BEAIH;
HAIR; KIDKEIS; LIVEB; LOHGS; MUSCLES;
PAHCBEAS; PLACEHTA; DBIHE; MERCUBI ;
METALS; BIOACCUHDLATIOH; FOOD
PBESEBVATIVES; OCCUPATIONAL HAZABDS;
POEDLATIOK EXPOSOSE; BORll AEEiS;
DBBAH SBEAS
BEFEEEHCE
Kuhnert, P.M.
Kuhnert, B. B.
Erhard, p.
1981
American Journal of
Obstetrics anS
Synecology 139:209-213
Lindh, U.
Brune, D.
Nordberg, G.
Hester, P.-O.
1960
Environient 16:109-116
Schiele, R.
Freitag, E. H.
Schaller, K.H.
Schellnann, B.
» el tie, D.
<981
Zentralblatt fuer
Bakteriologie,
Parasi tenkunde ,
Infektionskrankheiten,
und Hygiene. Erste
Abteilung. originals
Beihe B. Hygiene,
Setrieb s hygiene.
Praeventive Kedizin
173:15-62
Tucek, J.
Tucek, M.
1981
Journal of Hygiene,
Epidemiology,
Microbiology and
Imunology
25(H):35
-------
Mercury
71139-97-6
At» 200.59, HP -38.87 C, BP 356.72 C, VP 2X10 (E-3) II Hg at 25 C, 100 II Hg at 260 C
(CONTISOED)
TISSUE
6554
Hair
6555
Hair
6556
Hair
6557
Hair
EXPOSURE POUTE
ANALYTICAL
HETHOD
DA
_
HA
NUMBER
OF CASES
58
a) 29
b) 44
C) 7
d) 8
2
30
1 RANGE
1
1.41-2.61 ug/g
a) 234-12,786 ug/kg
b) 113-1,508 ug/kg
c| 8,209-135,508 ug/kg
d) 503-1,958 ug/kg
5.06X10 (E-6)-10. 16X10 (E-6
) q/cu cm
a) 14. 8' 154. 6 nmol/g
b) 12. 1-99.6 nmol/g
c) 0.9-16.3 nmol/g
d) 1.1-15.0 nmol/g
e) 10.5-143.9 nmol/g
f) 11.0-90.4 nmol/g
g) 9.0-127.5 nmol/g
h) 11.0-55.5 nmol/g
MEAN
1.85 ug/g
a) 1,038 ug/kg
b) 355 ug/kg
c) 29,673 ug/kg
d) 2,683 ug/kg
Sot given
a) 48.8 nmol/g
b) 43.9 niiol/g
c) 5. 1 nmol/g
d) 52.3 nmol/g
e)43.7 nmol/g
f) 38.2 nmol/g
g) 37.8 nmol/g
h) 31.1 nmol/g
(NEXT PAGE)
GENERAL INFORflATIOH
Bange of leans, 5 localities
Residents o£ Iceland
ADULTS; HAIS; ARSENIC; CADKIOK;
BEBCORI; HETALS; SELEHIOS; ZIBC
a) Children, rural area
b) children, urban area
c) Exposed workers
d) Nonexposed workers
9-11 yr old children and employees at
grain Eungicide treatient facility,
Czechoslovakia
CZECHOSLOVAKIA; ADULTS; AUTOPSIES;
CHILDREN: DEWBORB; BLOOD; EBAIS;
HAIR; ItlDBEIS; LIVER; LONGS; HdSCLBS;
EAKCEEJS: PLACENTA; US IKE; HERCURT;
METALS; BlOiCCOBULATION; FOOD
PRESERVATIVES; OCCUPATIONAL HAZARDS;
POPULATION EXPOSURE; RURAL AREAS;
DREAD AREAS
3 cm segients of single hairs
Some samples belov detection limits
IBIDIOH; HAIR; FOREDSIC flEDICINE;
HEASUEEHENT KETHODS; ABTlnONT;
ARSEHIC; BROHIHE; COPPER; SOLD;
LAHTHAHUM; BANGANESE; BEBCOBI;
BETALS; SELEHIOH; SILVER; SODIDB;
SIROBTlnn; ZINC; INDUSTRIAL
ATHOSPHEHES
a) Bales, total Hg, 15 Hashed 1970
samples, reieasurei in 1981
t) Females, same aa a)
c) Hales, inorganic Hg, 15 washed
1970 samples, remeasared in 1991
d) Females, same as c)
e) Hales, organic Hg, a) minus c)
f) Females, organic Hg, b) minus d)
g) Hales, organic Rg, 15 unwashed
samples, original 1970 measurements
h) Females, same as g)
Higher 1981 Measurements attributed
to different treatment of samples
2-61 yr olds, high fisb consumption,
Japan
JAPAK; ADOLESCENTS; ADULTS; AGE;
CHILDREN; SIX; HAIR; BERCOET; HERCURI
INORGANIC COMPOUNDS; HERCURT ORGANIC
COBPOONDS; HETALS; BIOJCCOBOLATION;
FISHES; FOODS; POPULATION EXPOSURE
Johannesson, T.
LUQde, G.
Steinnes, E.
1981
Acta Pharmacologica et
Toxicologica 18:185-189
Tucek, J.
Tucek, H.
1981
Journal of Hygiene,
Epidemiology,
Hicrobiology and
Immunology
25(l|):354-363
Dybczynski, E.
Boboli, K.
1976
Journal of
Radioanalytical
Chemistry 31:267-289
Suzuki, T.
Xaaamoto, B.
1982
Bulletin of
Environmental
Contamination and
Toxicology 28:186-188
-------
nercury
7039-97-6
Hg
At» 200.59, HP -38.37 c, BP 356.72 C, If 2X10(E-3) mm Bg at 25 C, 100 mm Hg at 260 c
(COMTIflDED)
TISSOE
6558
Kiclney
6559
Kidney
6560
Liver
6561
Liver
BXPOSOEE BOOTS
AHALYTICAL
METHOD
AAS
AAS
AAS
AAS
SOMBER
OF CASES
51
83
51
30
RANGE
_
a> <2.5-801 ug/kg
6) <2. 5-153 ug/kg
c) <2. 5-801 ug/kg
a) 4.3-911.0 ug/kg
b) Not given
c) Sot given
d) Mot given
e) Not given
f) Hot given
g) Hot given
h) Hot given
a) <2. 5-137 ug/kg
i» <2. 5-137 ug/kg
c) 16-156 ug/kg
d) <2.5-158 ug/kg
e) <2. 5-158 ug/kg
f) 8-121 ug/kg
0.005-0.25 ug/g
Wet ut
(NEXT
MEAN
a) 96.0 ug/Xg
b) 95.5 ug/kg
c) 99.9 ug/kg
Median
a) 90.1 tor- 130.2
ug/kg
b) 158. 1 ug/kg
c) 39.1 tor- 30.6
ug/kg
d) 131.6 *or- 238.2
ug/kg
e) 61.0 tor- 62.8
ug/kg
f) 123.7 tor- U6.7
ug/kg
g) 93.5 tor- 118.7
ug/kg
h) 58.0 ug/kg
S.E.
a) 58.0 ug/kg
6) 55.5 ug/kg
c) 62.0 ug/kg
d) 51.0 ug/kg
e) 58.5 ug/kg
f) 55.0 ug/kg
Median
Not given
PAGE)
GENERAL IHTORBATIOH
a) Total
b) Hen
c) Woman
Autopsies, Germany
GEBBANV; AUTOPSIES: BRAIN; KIDNEYS;
WEB; MERCOEy; BETtLS
a) All saiples
b) 0-9 yr olds, 2 sanples
c) 10-19 yr olds 6 samples
d) 50-59 yr olds 15 samples
e) 69-69 rr olds 21 samples
f) 70-79 yr olds 23 samples
g) 80-89 7r olds 11 samples
h) 90-96 yr olds 2 samples
Postmortems
Czechoslovakia, 1980
CZECHOSLOVAKIA; ADOITS; AUTOPSIES;
CBIIDBZH; NEUBORH; B10OB; SKtIS ;
BAIE; KID»EYSJ LITEE; LONSS; BOSCLES;
PANCREAS; PLACENTA; URISE; nERCORI;
I1ETA1S; BIOACCUHOLATIOHJ FOOD
FRESERVATITES; OCCOPATIONA1 HAZARDS;
POPOZATIOH EXPOSURE ; RDRAi AREAS;
OPBM1 ABEAS
a) Total
b) Hen
c) Nomen
d) Total
e) Hen
f) Women
left (a-c) and right (d-f) lobes
Autopsies, Germany
GERgAKI; AUTOPSIES: BRAIN; KIDNSTS;
LITEE; (IERCORI; HETALS
Category 1 (first priority element)
as proposed by International Workshop
on Monitoring Environmental Materials
and Specimen Banking
Autopsies, Baltimore, MD,
Kinneapolis, UN, and Seattle, HA
flAHtLAND: HINNESOTA; BASHIHGTON;
AOTOPSirS; tI?ER; HEASOBEHEHT
METHODS; ALUSISBfl; iDTIMOSr,- ABSESIC;
EARIOM; CAD8IOB; CHBOMIOB; COBALT;
COPfEE; FLUOEISE; IEON ; LEAD;
HANGANESE; 9ERCOBI; BOLTBDENDH;
NICKEL; RUBIDIUM; SELENIUM; SILVER;
STROHTI0H; TH4LLIOB; TIN; VANADIOTI;
IIHC; POPOL»TIO» EXPOSURE
REFERS KCE
Schiele, R.
Fteitag, E. a.
Schaller, K.H.
Schellmann, 3.
Wei tie, D.
1981
Zentralblatt fuer
Bakteriologie,
Parasi tenkunde ,
Infektionskrankheiten,
und Hygiene. Brste
Abteilung. Originale
Reihe B. Hygiene,
Betriebshygien e.
Praeventive Bedizin
173:15-62
Tucek, J.
Tucek, M.
1981
Journal of Hygiene,
Epidemiology,
Microbiology and
Imnunology
25(1):351-363
Schiele, 8.
Freitag, E.M.
Schaller, K.H.
Schellmann, B.
Weltle, D.
1931
Zentralblatt fuer
Bakteriologie,
Parasi tenkunde.
Infektionskrankheiten,
und Hygiene. Erste
Abteilung. Originale
Reihe B. Hygiene,
Betriebshygiene,
Praevective nedizia
173:15-62
Harrison* S.R.
Zeisler, R.
Bise, S.A.
1981
EPA 600/S1-81-025, 6
PP-
—1
01
-------
Mercury
7939-97-6
Bg
AtH 200.59, HP -38.87 C, BP 356.72 C, VP 2X10(E-3)
Hg at 25 C. 100 »
(COSTIHUED)
TISSUE
6562
liver
6563
Lung
6564
Wuscle
EJCPOSOBE ROOTE
AH1LYTICAL
METHOD
AAS
AAS
AAS
NOPIBEB
OP CASES
87
75
83
BAHGE
a) 4.1-528.0 ug/kg
b) Hot given
c) Hot given
d) Sot given
e) Hot given
f) Hot given
g) Mot given
h) Hot given
a) 2.0-280.0 ug/kg
b) Not given
c) Hot given
d) Not given
e) Not given
£} Hot given
g) Hot given
h) Hot given
a) 0.9-45.0 ug/kg
b) Hot given
c) Hot given
d) Hot given
e) Hot given
£) Hot given
g) Hot given
h) Hot given
MEAN
a) 47.9 +or- 63 .a
ug/kg
b) 22.0 ug/kg
c) 41.7 *or- 47.3
ug/kg
d) 67.0 +or- 121.1
ug/kg
e) 36.4 +or- 23.3
ug/kg
f) 44.1 +or- 36.3
ug/kg
g) 46.0 +or- 28.4
ug/kg
h) 9. 1 ug/kg
S.B.
a) 25.3 +or- 37.6
ug/kg
c) 21.0 ug/kg
c) 16.0 +or- 25.3
ug/kg
d) 26.4 +or- 26.2
ug/kg
e) 23.8 -+or- 28.2
f) 33.3 tor- 61.7
ug/kg
g) 18.5 +or- 14.3
ug/kg
h) 18. 1 ug/kg
5.E,
a) 7.2 *or- 9.3 ug/kg
b) 7. 1 ug/kg
c) 8.7 tot- 15.0
ug/kg
d) 9.9 *or- 13.5
ug/kg
e) 6.8 tor- 7.4 ug/kg
f) 7.5 *or- 9.6 ug/kg
g) 4.3 »or- 1.9 ug/kg
h) 1.8 ug/kg
S.E.
GEREBAL IHF08HATIOH
a) All samples
b) 0-9 yr olds, 2 samples
c) 40-49 yr olds 6 samples
d) 50-59 yr olds 17 samples
e) 60-69 yr olds 21 samples
f) 70-79 yr olds 24 samples
g) 80-89 yr olds 15 samples
h) 90-96 yr olds 2 saiples
Postmortems
Czechoslovakia, 1980
CZ1CHOSLO»»!!I«; ADULTS; AOTOPSIES;
CBILDBE5; BEHBOBK; BLOOD; EBUIK;
BtlB; KIDKETS; LI7EK; LOIIGS; R0SCLES;
P1ICBEAS; PLACESTA; DRIHE; DEBCOST;
HETILS; BIO»CCO»OLiTIO»; FOOD
PRESERVATIVES; OCCUPATIONAL BAZJBDS;
POPOLATIOH EXPO SORE; BOTIAL ABEAS ;
DBBin ABE1S
a) All samples
b) 0-9 yr olds, 2 samples
c) 40-49 yr olds 5 samples
d) 50-59 yr olds 14 samples
e) 60-69 yr olds 21 samples
f) 70-79 yr olds 20 samples
g) 80-89 yr olds 11 samples
h) 90-96 yr olds 2 samples
Czechoslovakia, 1980
CZECHOSLOVAKIA; iBOLTS : AUTOPSIES;
CBiLDBEN; HESBOP.H: BLOOD; BBAII;
B1IB; KIDHEIS; LIVER; UIHGS; HQSCLES;
PAUCBEAS; PLACENTA; ORISE; HEHCOaT;
BETALS; BIOICCURDUTIOI; FOOD
PBZSEBv«TI»IS; OCCOPAIIOBll H»Z»BDS;
POPOLATIOR EIPOSDBE; ROEAL AREAS;
DREAM ABEAS
a) All samples
b) 0-9 yr olds, 2 samples
c) 40-49 yr olds 6 samples
d) 50-59 yr olds 15 samples
e) 6.0-69 yr olds 21 samples
£) 70-79 yr olds 23 samples
g) 60-89 yr olds 14 samples
h) 90-96 yr olds, 2 samples
Postmortems
Czechoslovakia, 1980
CZECHOSLOVAKIA; JDOLTS; AUTOPSIES;
CHILDBEH: IEIBOBK: BLOOD; BBAII:
HUB; KIDiETS: LITEB; LU1GS; HOSCLES;
PUCREIS; PLACESTl; OKIIS; SEECOEt;
nETALS; BIOACCDHOLlTIOl; FOOD
PBISEBViTITES; OCCOPATIOBAL BAZABOS;
POPOLATIOK EIPOSDBE; BUBAL ABEAS;
DBBAII ABE1S
BETEBEBCE
Tucek, J.
Tucek, B.
1981
Journal of Hygiene,
Epidemiology,
Microbiology and
Immunology
25(4):354-363
Tucek, J.
Tucek, n.
1981
Journal of Hygiene,
Epidemiology,
Hzcrobiology and
Immunology
25(4):354-363
Tucek, J.
Tucek. a.
1981
Journal of Hygiene,
Epidemiology,
flicrobiology and
Immunology
25(4): 3 54-363
[IEXT PAGE)
-------
Hercury
71139-97-6
Hg
ItW 200.59, BP -38.87 C, 8P 356.72 C. vp 2X10(E-3)
at 25 C, 100 •> Hg at 260 C
(COHTIHDED)
( TISSOE
1
6565
Pancreas
6566
Placenta
6567
Placenta
6568
Placenta
EXPOSURE BODTE
I ABALTTICAL
BETHOD
.. -
AAS
GC-EC
AAS
SC
BOHBEB
or CASES
27
2ft
1
2«
RAISE
a) 1.6-259.0 ug/kg
b) Hat given
c) Hot given
d) Hat given
e) Hot given
f) Hat given
Hot applicable
Sot given
HEAH
1
a) 29.5 *or- 50.7
ug/kg
b) 12.5 *or- 12.3
ug/kg
c) 35.1 tor- 38.3
ug/kg
d) 14.1 *or- 15.1
ug/kg
e) 16.9 *or- 80.5
ug/kg
f) 7.7 ug/kg
S.E.
5.3 *or~ 3.2 QQ/Q
12.9 ug/kg
5.3 *or- 3,2 ng/g
GENE6»L IHFOBBATIOH
a) All saaples
b) »0-*9 vr olds 3 saaples
c) 50-59 yr olds 6 samples
d) 60-69 yr olds 7 samples
e) 70-79 yr olds 9 samples
f) 80-89 yr olds 2 samples
Postaortems
Czechoslovakia, 1980
CZECHOSLOVAK I»; A DOLTS; AUTOPSIES ;
CBILDBES; NE8BOBH; BLOOD; EEAIK:
HUB; KIDHETS; LITEE; LOKGS: HOSCLES;
PHCDEkS; PLACEKT1; OTIUS; OTBCOBI J
HET11S; BIOACCOnOL»TIO»: FOOD
PEESEBftTITES; OCCOPATIOII1L HAZARDS;
PCPOLATION EIPOSUBE; EOBAL ABEiS;
DBBAH ABEAS
1.1 ng/g) significantly lover (p <
O.OOt)
Ho correlation vith inorganic Hg
cells or plas»a
Patients residing in or near
Cleveland, OH
OHIO; ADULTS; DEVBOBH; BLOOD PLAMA;
EHyTHBOCYTES; PLACEHTi ; COKPABATITE
EVALUATIONS; 8EBCOBT IHOBGAH1C
coaponHDS; BEBCHBY ORGANIC COHPOOHDS;
BETALS; PSESHAHCI; BERCOBy
Stillbirth
Czechoslovakia, 1980
CZECHOSLOVAKIA: ADULTS: AOTOP3IES;
CHILDREH; NEBBOBN; BLOOD; ERAIH:
BATE; KIDHETS; LIVER; LnNGS; BOSCLES;
EASCREAS; PLACEHTA; OBINE; BERCOBT;
BETALS; BIOACCDRDLATIOR; FOOD
FBESEBVATIVES; OCCUPATIONAL HAZARDS;
POPULATION EIPOSDRE; RURAL AREAS:
OREAH AREAS
Significantly higher than nethyl Hg
(1.» »or- 1.1 ng/g)
Patients residing in Cleveland, OH
PBEGHAUCI; HERCnBT; HEBOJKT IHOSGASIC
COnPODKDS; BETHIL RADICALS: BLOOD;
P1ACBHTA; OHIO; FETOS: EBTTHROCTTES
BEFEBEHCE
T«ceX, J.
Tucek, n.
1961
Journal of Hygiene,
E pideB iolog y.
Bicrobiology and
I»unologv
25(1) :35»-363
Knhnert, B. B.
Erhard, P.
1981
Obstetrics and
Gynecology 139:209-213
Tucek, J.
Tucek, n.
1981
Epideaiology,
Hicrobiology and
iBBUnology
25(») :35»-363
Knhnert, P.B.
Knhnert, B. R.
Erhard, P.
Prochaska, A. L.
1980
Proceedings, 0 Diversity
of Rissouri Annual
Conference on Trace
Substances in
Environmental Health
1«: 182- 188
(HEIT PAGE)
-------
Bercury
7439-97-6
Bg
At« 200.59, HP -38.87 c, BP 356.72 C, VP 2X10(E-3) u
at 25 C, 100 mm Hg at 260 c
(COHTIHUED)
6569
Orine
6570
Urine
EXPOSURE BOOTS
ANALYTICAL
BETHOD
its
NOB BEE
OF CASES
it) 29
b) 44
C) 7
«> 7
.
23
BANGE
a) 0.1-10.4 ug/1
b) 0.2-8.3 ug/1
c) 1.7-16.4 ug/1
d) 0.9-8.9 ug/1
53.0-746.0 ug/g
creatinine
BEAN
ai 1.7 ug/1
b) 1.1 ug/1
c) 8.8 ug/1
a) 2,8 ug/1
Not given
GENERAL INFORHATION
a) Children, rural area
b) Children, urban area
c) Exposed workers
d) Nonexposed workers
9-11 yr old children and employees at
grain fungicide treatment facility,
Czechoslovakia
CZECHOSLOVAKIA; ADULTS; AOTOPSIES:
CHILDBEN; NESBOBN; BLOOD; ERAIN;
HAIP; KIDNEYS: LIVER: LONGS; BOSCLES;
PANCREAS: PLACENTA; URINE; BERCUBY;
8ETJLS; BIOJCCBMOIATIOS; FOOD
PRESEEVATIVES; OCCOPATIOHAL HAZARDS;
POPULATION EXPOSDBE; EORAL ABEAS;
DBBAN ABEAS
Chemical plant workers, average
workplace tine 8.25 yr
GERHANY; ADULTS; BLOOD: ORINE;
COBPARATI»E EVALOATIOSS; INDOSTBIAL
BEDICINE; CADBIOB; LEAD; BERCDRY;
BETALS; PEOTIIBS: HEALTH HAZARDS;
IHDOSTRIAL PLANTS: OCCOPATIOHAL
HAZARDS; SBELTEBS
REFERENCE
Tucek, J.
Tucek, M.
1981
Journal of Hygiene,
Epidemiology,
Hicrobiology and
25(4):354-363
Schaller, K.H.
Gonzales, J.
Thurauf, J.
Schiele, R.
1980
Zentralblatt fuer
Bakteriologie,
Parasitenkunde,
Infektionskrankheiten
und Hygiene, Abteilung
1. Originale, Eeihe B.
Hygiene, Preventive
Bedizin 171:320-335
Hercury(1»), methyl-, ion (8 CI)
Bercury (1*). methyl- (9 CI)
22967-92-6
C-H3-Bg
B» 215.63
CX3
TISSOE
6571
Blood,
cells
6572
Blood,
cells
EIPOSOBE BOOTE
4SSLYTICAL
BETHOD
6C-EC
SC
NOBBER
OF CASES
a) 29
b) 29
a) 29
b) 29
,_.
BANGS
a) 0->6 ng/g
b) 0->6 ng/g
a) lot given
b) Not given
«EAN
a) 3.0 »or- 2. 1 ag/g
b) 3.9 »or- 3.0 ng/g
a) 3.0 +or- 2.1 ng/g
b| 3.9 »or- 3.0 ng/g
GENERAL INFORMATION
a) Maternal samples
b) Fetal samples
Correlation (p < 0.01) between a) and
b)
b) significantly higher than a) .
Inorganic Hg levels similar for a)
[2.-5 +or- 1.8 ng/g) but significantly
lover for b) (1.4 tor- 1.2 ng/g)
Patients residing in or near
Cleveland, OH
OHIO: ADULTS; NEHBORN; BLOOD PLASBA;
ERTTHROCTTES; PLACENTA: COBPtRATIVE
EVALUATIONS; BEBCOBY INORGANIC
COBPODNDS; MERCURY ORGANIC COMPOUNDS;
BETALS; PKEGNANCT; BERCtlRY
a) Baternal erythrocytes
b) Fetal erythrocytes
b) significantly higher than a)
Patients in active labor, Cleveland,
OB
PREGNANCY ; BiRCORY; HERCDBY INORGANIC
COBPODNDS; BETHYL RADICALS; BLOOD;
S>LIC?,«T1; OHIO; IETDS; ERYTHROCYTES
REFERENCE
ruhnert, P.B.
Kuhnert, B.R.
Erhard, P.
1981
Gynecology 139:209-213
Kuhnert, P. H.
Kuhnert, B.R.
Erhard, P.
Prochaska, A. L.
1980
proceedings, University
of Missouri Annual
Environmental Health
14:182-188
1
(KBIT PAGE)
-------
Mercury(!»), methyl-. Ion (8 CI)
BercuryO*) , methyl- (9 Ct)
22967-92-6
C-B3-Hq
Hi 215.63
(CONTINUED)
TISSUE
6573
Blood,
plasma
6571
Placenta
6575
placenta
EXPOSOBE ROUTE
ANALYTICAL
METBOD
GC-EC
GC-EC
GC
SUMBEE
OP CJSES
25
25
24
24
1 BANGS
a) Hot given
b) Hot given
Not given
Not given
BEAU
a) 0.4 »or- 0.2 ng/g
b) 0.4 +or- 0.3 ng/g
1. 4 +or- 1 . 1 ng/g
1.4 tor- 1. 1 ng/g
GESEBAL INFOBBATIOH
esitylene (8 CI)
enzene, 1,3,5-trim ethyl- (9 CI)
08-67-8
9-H12
W 120.2, BP -44.8 C, BP 164.7 C, VP 10 mm Bg at 47.4 C
TISSOE"
a) Maternal samples
b) Fetal saiples
Mot significantly different.
Inorganic Hg levels significantly
higher (1.7 and 2.6 ng/g,
respectively) for both a) and b)
Patients residing in or near
Cleveland, OB
OHIO; ADULTS: NEUBOBH; BLOOD PLASMA;
F.BYTBBOCITES; PLACENTA; COMPAEATITE
EVALUATIONS; HE8CUBY IHOBGANIC
COBPOOHDS; BEBCOBT OBGABIC COBPOONDS;
METALS; PPEGNANCY; MEBCOBY
Significant correlation with maternal
and cord red blood cell levels of
organic Bg, bat not with maternal or
fetal plasma levels
Placental inorganic Bg level (5.3
+or- 3.2 ng/g) significantly higher
(p < 0.001)
Patients residing in or near
Cleveland, OH
OHIO; AUDITS; NEWBORN; BIOOD PLASMA;
EBYTBBOCYTES; PLACENTA; COMPAEATIVE
EVALUATIONS; BEBCOBY INOBGANIC
COMPOUNDS; MEBCUBY OEGANIC COBPOONDS;
METALS; PBEGSANCY; BEECUBY
Significantly lower than inorganic
mercury (5.3 +or- 3.2 ng/g)
Patients residing in Cleveland, OB
PEEGKASCY; BEECOSY.: BEECOEY INOEGASIC
COBPOUNDS; METHYL BAOICALS; BLOOD;
PLACENTA; OBIO; FETDS; EEYTHBOCYTES
Knhnert, P.B.
Kuhnert, B.B.
Erhard, P.
1981
American Journal of
Obstetrics and
Gynecology 139:209-213
Kuhnert, P.M.
Kuunert, B.E.
Erhard, P.
1981
American Journal of
Obstetrics and
Gynecology 139:209-213
Kuhnert, P.M.
Kuhnert, B.R.
Erhard, P.
ProchasXa, A. L.
1980
Proceedings, University
of Missouri Annual
Conference on Trace
Substances in
Environmental Health
14:182-188
6576
Breath
EKPOSOBE BOUTE
...
ANALYTICAL
BETHOD
GC/BS
BOnBEB
OF CASES
28
BAHGE
.
0.7-4 ng/1
BEAN
1.7 ng/1
GENERAL INFORMATION
Estimated from graph
Bealthy 18-60 yr olds, uonsmokers.
Eigid protocol 14 days before and
during study to minimize number and
amount of exogenous constituents.
AtOLTS; BBEATB; ALCOBOLS; CHLORINE
CEGANIC COMPOUNDS; CHLOBOBENZENES
BEFEBENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, B.
Claudio, B. P. A.
1977
Journal of
Chromat ograpaic Science
15:239-244
-------
Methane, dichloro-
75-09-2
C-B2-C12
B» 84.9J. HP -95.1 c, BP 39.75 C. VP 380 » Hg at 22 C
6577
Blood
6576
Flood
6579
Breath
EXPOSORE ROOTE
Inhalation
Inhalation
Inhalation
JNJLTTICAL
NETHOD
GC
OC/BS
BOSSES
OP C1SES
a) 1
b| 1
O 1
d) 1
18
a) 1
b| 1
c) 1
d) 1
BADGE
a) 2-0. 12 Bg/i
b) O.B-0.03 Bg/1
c) 1.7-0.1 Bg/1
d) 0. 8-0. 02 Bg/1
a) 270-520 ppb
b) 270-560 ppb
c) Hot given
a) 70-0.4 ppn
b) »0-0 ppi
c) 60-0.5 ppo
d) 40-0 ppB
a) Not given
b) Not given
c) Hot given
d) Not given
a) 370 ppb
b) 414 ppb
cj < tOQ ppb
a) Not given
b) Not given
c) Hot given
d) Not given
GEHERAL INFQRHATIOB
a) Saoker, 3 he after start of
exposure and 6 hr postexposure. Ret
increase in COHb 3.OX after 7 1/2 hr
of exposure
b) Nonsaoker, 8 hr after start of
exposure and 16 hr postexposure
c) Volunteer, exercising at work
intensity of 28 mi 02 Bin/kg, 8 hr
after start of exposure and 16 hr
fostexposure
d) Volunteer, sedentary, 8 hr after
start of exposure and 7 hr
costexposure
B hr exposure to 100 pp*
Estimated froa graphs
Data also for other studies
23-27 yr olds
CARBON MONOXIDE; BLOOD; UBINE;
BE BAT R; CHLOEIHATED HTDROCAHBOWS
a) Painters, nonsaokers. Mean
baseline COHb of about 28* with
•axinua, increase of <1H during test
b) Painters, saokers. Bean baseline
COHb of 6.1* with maxima increase of
2.5* during test
c) Controls, below detection li»it.
Mean baseline COHb of 2 saokers 5.6*
vith Baxinua increase of 1.5X during
test. Nonsaokers baseline siailar to
a) vith no changes
Hean aethylene chloride exposure in
26 ain, Q50 ppa. Paint foraulation
contained 29* by vt. SiBalated hoBe
use of spray paint in exposure
chaaber.
23-H9 yr Olds
BLOOD; ADOLTS; CHLORINATED
HTDBOCABBOHS; PAINTS; SHOKIBG;
TOBACCOS
a) Saoker, 1 hr after start of
exposure and 6 hr posteiposare
b) Nonsaoker, 8 hr after start of
exposure and 16 hr postexposure
c) Volunteer, exercising at work
intensity of 28 ml 02 Bin/kg, 8 hr
after start of exposure and 16 hr
post exposure, net excretion of CO
14.34 »Bol
d) Volunteer, sedentary. 8 hr after
start of exposure and 7 hr
postexposure. Net excretion of CO
2.66 BBOI
8 hr exposure to 100 pp»
Estimated froa graphs
Conversion to CO 26* in c) and 10* in
d)
Data also for other studies.
23-27 yr olds
CARBON MONOXIDE; BLOOD; UBIHS;
BREATH; CHLORINATED HYDROCARBONS
(NEXT PAGE)
DiVincenzo, S.D.
Kaplan, C.J.
Toxicology and Applied
Pharmacology 59: 141-148
Stevenson, H. F.
Cooper, G.t.
Chenoweth, H.B.
1978
Clinical Toxicology
12{5) :551-561
DiViccenzo, G. D.
Kaplan, C.3.
Toxicology and Applied
Pharmacology 59:141-148
CD
O
-------
Methane, dichloro-
75-09-2
C-B2-C12
MS 84.94, HP -95.1 C, BP 39.75 C, »P 380 u Hg at 22 C
(CONTINUED)
6580
Urine
EXPOSURE BOUIE
ANALYTICAL
« El HOD
GC
. . ..
NDIEEB
0? CASES
a» 3
b) 2
BADGE
a) 142-318 ug/Say
b) 138-242 ug/day
HEAD
a) Hat given
b) Not given
GENERAL INFORMATION
a) Exercising and sedentary
volunteers
t>) Smokers
Ho apparent correlation with work
intensity or snoking
23-27 yr olds
CABBON BONO HIDE; BLOOD; DBINE;
BBEATB; CHLORINATED RTDBOCABBOBS
_
BEFEBZNCE
DiVincenzo, G.D.
Kaplan, C.J.
Toxicology and Applied
Pharmacology 59:141-148
Methane, dichlorodifluoro-
75-71-8
C-C12-F2
an 120.92, IIP -158 C, BP -29 C, VP 5 ati at 16.1 C
TISSUE
6581
Blood
EIPOSDBE BOOTE
Inhalation
ANALYTICAL
KETBOD
StMEEB
OF CASES
8
BUDGE
4) 0-2. 3 ug/Bl
b) 0.2-3.13 ug/ml
DEAD
a) Not given
b) Not given
GBHEB1L I»FOB»ATIOJ
a) 1 inhalation
b) 2 inhalations
Range of peak values 10-20 sec after
using ventolin aerosol inhaler
31-66 yr old patients with asthia or
chronic bronchitis
BLOOD; DRUG THEE APT; FLOOR HE
COMPOUNDS; IBHALATIO*
-
REFBBESCB
Dollery, C. T.
Willians, P.M.
Draff an, s. H.
Vise, G.
Sahyoan, R.
Paterson, J.R.
Walter, J.B.
1974
Clinical phanacology
and Therapeutics
15(1) : 5 9-66
00
Methane, dichloronitro-
7119-89-3
C-B-C12-N-02
B« 129.93, BP 107 C
TISSDE
6582
Breath
EXPOSURE PODTB
ANALTTICAL
METHOD
_
GC/MS
NUHBEfi
OF CISES
28
BANGE
2-17 ng/1
BEAN
5.5 ng/1
GENEBAL IBFOBBATIOI
..
Estimated froa graph
Healthy 18-60 yr olds, nonsnokers.
Bigid protocol 14 days before and
daring study to Binivize nanber and
aBonnt of exogenous constituents.
ADULTS; BBBATH; ALCOHOLS; CHLOBUB
OSGANIC COMPOUNDS; CBLOBOBEIZENES
BEFEBENCE
Krotoszynsfci, B.
Gabriel, G.
O'Neill, B.
Claudio. H. P. A,
1977
Journal of
chrotatographic Science
16:239-244
-------
Methane, tricblorofluoro-
75-69-1
C-C13-F
BB 137.38. HP -111 C, BP 23.7 C at 760 •• Hg, 6.8 C at 100 •• Bg, -9.1 C at 200 •• Hg,
at 10 mm Hg, -67.6 C at 5 •• Bg, -81.3 C at 1.0 mm Hg
-23.0 C at 100 •• Hg, -32.3 C at 60 cm Hg, -39.0 C at 10 mm Rg, -19.7 C at 20 » Hg, -59.0 C
TISSUE
6583
Blood
EXPOSURE EODIE
.
Inhalation
iNALYTICSI,
MET BOD
GC
NUB BEE
OF CASES
e
BINGE
a) 0.26-2.0 ug/il
b) 0.53-3.1 ug/ll
BEAU
a) Not given
b) Not given
GEHEEAL IHFORBATION
a) 1 inhalation
b) 2 inhalations 30 sec apart
Range of peak values 10-20 sec after
using Ventolin aerosol inhaler
31-66 yr old patients with asthia or
chronic bronchitis
B10OD; DRUG THERAPY; FLUORIHE
CONFOUNDS; INHALATION
REFERENCE
Dollery, C.T.
Williams, F.H.
Draff an, G.H.
Rise, G.
Sahyoun, H.
Paterson, J.w.
Walker, J.R.
1971
Clinical Pharmacology
and Therapeutics
15(1): 59-66
Hethanearsonic acid, sodiui salt (8 CI)
Irsonic acid, methyl-, sodiui salt (9 CI)
22969-21-0
C-H5-»s-03.x-Na
nv 189, BP 113-116 C
TISSUE
.6581
Urine
EXPOSURE ROUTE
Ingestion
ANALYTICAL
HETHOD
AAS
son BEE
OF CASES
1
BADGE
Not given
BEAN
391.7 ug
GENERAL IBFORBATION
0-96 hr, total output after 500 ug
dcse. 0% inorganic arsenic, 87.1%.
flonoiethylarsonate, and 12.6%
dimethylarsinate. Data corrected for
basal excretion rate of 7. 1 ug/21 hr
Healthy 27-12 yr olds
ADULTS; URIHE; COHPAEATI7E
EVALUATIONS; iRSEKIC; AESENIC OBGAHIC
COHPOD»DS; IflBTiBOlITES
REFEBENCE
Buchet, J.P.
Lauverys, R.
Roels, H.
1981
International archives
of Occupational and
Environmental Health
18:71-79
oo
NJ
nethanol
67-56-1
C-H1-0
B» 32.01, HP -97.8 C, BP 61.7 C
6585
Breath
EXPOSURE ROUTE
ANALYTICAL
HETHOD
GC/BS
• OSBEB
OF CASES
28
BABGE
0.10-0.21 ng/1
BEAN
0.15 ng/1
GENERAL IHFOSHATION
_
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
during study to minimize number and
amount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COBPOUNDS; CHLOROBENZEUBS
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Clandio, B.P.A.
1977
Chromatographic Science
15:239-211
-------
Bethyl sulfide (8 CI)
Bethane, thiobis- (9 CI)
75-18-3
C2-H6-S
US 62.13, at -83.2 C, BP 37.5-38 C
6586
Breath
EXPOSURE EOOTE
ANALYTICAL
HETHOD
GC/HS
ROHBEB
OF CASES
28
BADGE
0.7-5 ng/1
-
2 ug/1
GENEBAL INFOBBATION
Estimated froa gra*>h
Healthy 18-60 yr olds, nonsaokers.
Rigid protocol 11 days before and
during study to ilniiize nunber and
aiount of exogenous constituents.
ADULTS; BBEJTH; AICOHOLS; CHLOBINE
OBGANIC COBPOONDS; CHLOBOBENZESES
Ktotoszynski, B.
Gabriel, G.
O'Neill, R.
Claudio, H.F.I.
1977
Journal o£
Chronatographic Science
15:239-2««
Iethyl-1-heptanone (Ho postings in CHEBLIDE).
C8-B16-0
B« 128.21
6587
Breath
EIPOSOBE FOOTS
IHtLITIOL
METBOD
GC/BS
HOflBEB
OF C1SE5
28
-
B1HGE
0.6-8 ng/1
HEAH
2.1 ng/1
GEIIBAL IKFOKBATION
Estimated froi graph
Healthy 18-60 yc olds, nonsnokers.
Bigid protocol 14 days before and
during study to liniiize umber and
aaount of exogenous constituents.
ADDITS; BBEATH; ALCOHOLS; CHLOBIHE
OBGAHIC COnPOUNDS; CHLOB08EHZEHES
EEPEBESCE
.
Rrotoszynski, B.
Gabriel, G.
O'Heill, H.
Claudio, n.P. 1.
1977
Journal of
Chcoiatogtaphic Science
15:239-2««
oo
7K39-98-7
no
»tt 95.94, «P 2622 C, BP 1825 C (approx), TP 1 » Hg at 3300 C, 10 an Hg at 3770 C
TISSUE
6538
Adrenal
gland
EIPOSDRE ROCTE
_.
AHALYTICAL
BETBOD
ES
.. _ __.. _. ..
«OBBEB
OF CASES
7
.. ._
BAHGE
Not given
BEAN
0.30 tor- 0.09 ppn
dry »t
GENERAL INFOBB&TICN
Norial tissue
Autopsies
Japan
JJPAN; ABOLTS; AOTOPSIES; ADBBSAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNEIS; LI'EB ; LUNGS;
IIBPH NODES; PASCBEAS; SPLEEN;
STOBACH; THT80IB GLANDS; TBACHEA;
ALOBIHDH; BAEIUH; CADBIOK; CALCIHB;
CBBOHIDK; COBALT; COPPEB; IBON; LEAD;
BAGNESIOB; BANGANESE; BETALS;
BOirBDEHIFB; HICKEL; PHOSPHCBBS;
FOTASSIUB; SILICON; SILVEB; SODIOS ;
S180STIDB; TIN; TITANIDH: TAHADIOB;
ZINC; BIOACCDBOLATION; HEA1TH
HAZABDS; OCCDPATIONAL HAZAEDS;
T01IGOE; ZIRCONIUB; ELEBENTS
(NEXT PAGE)
Teraoka, H.
1981
Archives of
Environaental Health
36(») : 155-165
-------
olybdenuH
ft 39-98-7
itw 95.90, HF 2622 C, BP US25 c (approx), 7P t » Hg at 3300 C, 10 u tig at 3770 C
(CONTINUED)
TISSUE
6589
korta
6590
Bone
659 1
Rait
EXPOSURE HOOT!
ANALYTICAL
BETBOD
IS
ES
H
iniBZS
OF OSES
7
5
54
I BADGE
Mot given
lot given
0.05*0. 16 ug/g
BEAK
<0.2 ppB dry wt
<2. 0 ppm dry vt
Not given
GENERAL INFORBATION
normal tissue
Autopsies
Japan
JAPAN; ADULTS: AOTOPSIES; ADRENAL
GLANDS; 40BIA: BONES; BEAST;
INTESTINES; KID NETS ; LIVER; LUNSS;
LYI1PR NODES; PANCBEAS; SPLEEN;
STOHACB; TSIBOID GLANDS; TRACHEA;
ALoniNun; BABIOH; CADBIUB; CALCIOH;
CHBOaiOH; COBALT; COPPER; IBON; LEAD;
DAGNESIDH; BANGANESE; HETALS;
ROLTBDENDH; NICKEL; PHOSPHOBDS;
POTASSIOB; SI1ICOS; SIL7EB ; SODIDII;
SIBOIITIDB; TIN; TITANIOH; TANADWH;
ZINC; BIOACCOHDLATION; BEALTB
BA2ABDS; OCCOPATIONAL HAZARDS;
T08GDE; ZIBCOIIIOB; BLEBESTS
Nornal tissue
Autopsies
Japan
JAPAN; ADOITS; ADTOPSIES; ADSENAL
GLANDS; AOBTA; BONES; BEABT;
INTESTINES; KIDKEIS; LITER; LONGS;
LTBPH NODES; PABCEEAS; SPLIEN;
STOBACH; TRIROID GIANDS; TBACBEI;
ALOHINUn; BAEIDn; CJDBHTfl; CAICIOB ;
CBBOBIDH; COBALT; COPPER; IBON: LEAD;
HAGRESIDH; BANGANESE; BETA IS;
BCLTBDENDB; NICKEL; PHOSPHOBUS;
POTASSIDB; SILICON; SILVER; SODIOB ;
STKOHTIOB; TIN; TIIAIIOfl; VANADIUB;
ZINC; BIOACCDBDLATION; HEA1T8
BAZARDS; OCCOPATIOBAL HAZARDS;
TONGOE; ZIBCOIIIOB; ELEHENTS
.
Range of leans, estimated from graph
Asvan, El Kharga, Assuit, Cairo, and
Alexandria, Egypt
EGTPT; BAIB; NAILS; ANTIHONY;
CADflltJH; CESIOH; CHKOBIaS; COBALT;
IRON; BANGANESE; BETALS; BOLTBDINDB;
SCABDItJB; SELENIHB; SILTEB; TONGSTEK;
ZINC; DRINKING SATED; POPULATION
EXPOS0RE; SOILS; OBEAN AREAS
BETE HENCE
Teraoka, B.
1981
Archives of
Environmental Bealth
36(1): 155-1 65
Teraoka, H.
1961
Archives of
Environmental Health
36(1):155-165
Kasperek, K.
lyengar, G*T*
FeinendegeDr L.E-
Hashish, 5.
Hahfouz, R.
1982
Science of the TotaL
Environaent 22:149-168
oo
(BEIT PAGE)
-------
nolybdenui
7139-98-7
no
At» 95.91, BP 2622 C, BP 1825 c (appro!), vp 1 u Hg at 3300 C, 10 •• Eg at 3770 C
(CONTINUED)
6592
Heart
6593
Intestine
6591
Kidney
EXPOSURE BOOTE
LYTICAL
ETHOD
BOB BBS
Ot CASES
a) 8
b) 2
c) 3
d) 1
e) 1
10
a) 8
b) 2
c) 3
d) 1
e) 1
EANGE
a) Hot given
b) <0.2-<0.2 PPB
c) <0.2-<0.2 ppB
d) Hot applicable
e) Hot applicable
Dry wt
Hot given
a) Hot given
b) <0.2-0.21 PPB
c) 0.22-0.13 PPB
d) Hot applicable
e) Hot applicable
Dry wt
BEAN
a) <0.2 ppB
b) <0.2 PPB
c) <0.2 PPB
d) <0.2 ppB
e) <0.2 ppB
Dry wt
<0.2 PPB dry wt
a) 0.51 +or- 0. 15 p
b) Not given
c) 0.33 ppB
d) <0.2 ppB
e) <0.2 ppB
Dry wt
GEHERAL INFORMATION
a) NorBal healthy Ben
b) ChroaiuB plating workers
c) ChroBate refining workers
d) Airplane painter
e) Stone Mason
Aatopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
G1ANDS; AORTA; BONES; HEIST;
INTESTINES; KIDHEIS; LIVER; LUNGS;
LIHPH NODES; PANCBEAS; SPLEEN;
STOHACH; TBTSOID GLANDS; TBACREA;
ALOHINOM; BABIUH; CADHIDH; CAtCIOH;
n: COBALT; CCPPEB; IBON; LEAD:
; HANGANESK; HETALS;
flCITBDEROB; NICKEL; PHOSPHCBOS;
POTASSIO»: SILICON: SILVEB; sooins;
STROSTIOB; TIH; TITAHIB!!;
ZINC; BIOACCDBDLATION; HEALTH
BAZABDS; OCCDPATIONAL HAZARDS;
TOHGDE; ZIBCONIUH; ELEBEHTS
Noraal tissae
Autopsies
Japan
JAPtH; ADOLTS; AOTOPSIES; ADBENAL
GLANDS; 10BTA; BONES; HEART;
IKTESTINES; KIDNEYS; LIVES; LONGS;
LIflPH NODES; PANCREAS; SPLEEN;
STOHACH; THI80ID GLAHDS; TBACREt;
ALDHINOn; BABIDH; CADKIHH; CALCIUH;
CBEOBIOH; COBALT; COPPER; IRON; LEAD;
KAGNESIDH; BANGANESE; BETALS;
HOLTBDENDB; HICK El; PHOSPHORUS;
POTASSIUM; SILICON; SILVER; SODIUM;
SIRONTIOB; TIH; TITANIUS; VANADIOn;
ZINC; BIOACCDHOLATIOH; HEALTH
HAZARDS; OCCOPATIOHAL HAZARDS;
TONSOE; ZIRCONIDB; ELEBENTS
a) Horaal healthy Hen
b) chroiian plating workers
c) cbroaate refining workers
d) Airplane painter
e) stone lason
Aatopsies
Japan
JAPAH; ADULTS: AUTOPSIES; ADREHAL
GLANDS; AORTA: BOHES; HEABT;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LTrPH NODES; PANCREAS; SPLEEN;
STOHACH: THYROID GLANDS; TRACHEA;
ALOniNDH; BARIUH; CiDBITJB; CALCIUH:
CHROBIUH; COBALT; COPPER; IBON; LEAD;
HlGNESIUn; H4KGANE3E: BETALS;
BOI.YBDENUB; HICKEL; PHOSPHOBOS;
POTASSIDB; SILICON; SILVER; SODIDH;
STRONTIDH; TIN; TITANIUH; VANADIDH;
ZINC; BIOACCOHULATIOH; HEALTH
HAZARDS; OCCOPATIOHAL HAZABDS;
TOHGHE: ZIBCOHIUB; ELEBENTS
(NEXT PAGE)
Teraoka, H.
1981
Archives of
Environmental Health
36(1) : 155-165
Teraoka, H.
1981
Archives of
Environaental Health
36(1):155-J«5
00
Ul
Teraoka* H.
1981
Archives of
Environmental Health
36(1):155-165
-------
Molybdenum
7439-98-7
Mo
AtH 95.94, MP 2622 C, BP 4625 C (approx), VP 1 mm Hg at 3300 C, 10 ma Hg at 3770 C
(CONTINUED)
6595
Liver
6596
liver
6597
Lung
EXPOSURE RODTB
ANALTTICAL
METHOD
ES
NA
ES
NUMBER
OP CASES
a) 9
b) 2
O 3
4) 1
e) 1
30
.
a) 12
b) 2
c) 3
d) 1
e) 1
BA«GE
a) Hot given
b) 1.3-1.4 ppm
c» 0. 60- 1.1 ppm
d) Not applicable
e) Hot applicable
Dry irt
0.4-1.6 ug/g
Wet wt
a) Hot given
b) <0.2-0.82 ppm
c) <0.2-2.2 ppm
d) Hot applicable
«1 Hot applicable
Dry wt
MEAN
a) 1.5 +or- 0.59 ppu
b) 1.4 ppm
c) 0.93 ppm
d) 0.78 ppm
e) 0.55 ppm
Dry wt
Not given
a) <0.2 ppm
b) Not given
c) Not given
d) <0.2 ppm
e| <0.2 ppm
Dry wt
GENERAL ISFORBATION
a) Normal healthy men
b) Chromium plating workers
c) Chronate refining workers
d) Airplane painter
e) stone nason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADTtENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNEYS ; LIVES; LOHSS;
LYflPH NODES; PANCBEAS; SPLEEN;
STOHACH; TBIROID GLANDS; TEACHEA;
M.D1I1TOH; BAKIDH; CADHIDB; CALCIDB;
CHBOnlDB; COBALT; COPPEF; IRON; LEAD;
HAGNESIDH; 8ANGANESE; HETALS;
BOLTBDENnB; NICKEL; PHOSPROBOS;
POTASSIOB; SILICON; SIL7ER ; SODIOfl;
STEONTinB; TIN; TITANIOB; VANADIDB;
ZINC: BIOACCOHnLATION; HEALTB
BAZABDS; OCCOPATIONAL HAZARDS;
TONGUE; ZI8CONIDH: ELEBENTS
Category 1 (first priority eleient)
as proposed by International workshop
on Monitoring Environmental Materials
and Specinen Banking
Autopsies, Baltimore, BD,
Binneapolis, UN, and Seattle, WA
RABTLAND; HINNESOTA; WASHINGTON;
AUTOPSIES; LIVER; BEASOREBENT
BETHODS; ALOSINnH; AHTIBONY: ARSENIC;
EARIOH; CADBIDB; CBBOfllOB; COBALT;
COPPER; ?ino8I»E; ISDN; HAD;
BANGANESE; BEBCDRI; BOI.TBDENOH;
NICKEL; BOBIDIDB; SELENIOH; SILVER;
STRONTIOB; THALLIDB ; TIN; VANADIUB;
ZINC; POPULATION EZPOSOBE
a) Normal healthy men
fi) chromium plating workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BEAST;
INTESTINES; KIDNEIS ; LIVEB; LUNGS;
LIltPH NODES; PANCREAS; SPLEEN;
STOMACH; THYBOID GLANDS; TRACHEA;
ALuRINUH; BA8IOB; CADBIDB; CALCIDB;
CBBOniUn; COBALT; COPPER; IRON; LEAD;
HAGNESIUB; BANGANESE; BETALS;
NOLTBDENUB; NICKEL; PHOSPBOROS;
POTASSIUM; SILICON; SILVER; SODIUB;
STBONTIDB; TIN; TITANIOB; VANADIUB;
ZINC; BIOACCDBDLATION; HEALTB
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUM; ELEMENTS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
Harrison, S.H.
Zeisler, R.
Wise, S.A.
1981
EPA 600/31-81-025, 6
pp.
Teraoka, H.
1981
Archives of
36(4) : 155-165
(NEXT PAGE)
OO
-------
BolybdenUB
7H39-98-7
Ho
AtR 95.91, IIP 2622 C, BP 1625 C (appcoi) , VP 1 » Bg at 3300 C, 10 BB Hg at 3770 C
(CONTINUED)
TISSUE
6598
Lymph
node
6599
Hail
6600
Pancreas
EXPOSURE ROUTE
ANALYTICAL
BETHOD
ES
NA
ES
HUH BEE
OF CASES
a) 3
b) 1
o) 3
a> i
e) 1
63
5
BA&GE
a) Sot given
b) Hot applicable
c) <0.4-0.64 ppii
d) Hot applicable
e) Hot applicable
Dry lit
0.07-0.33 ug/g
_
Hot given
a) <0.4 ppa
b) 0.41 ppi
c) Bot given
d) <0.4 ppa
e) <0.4 ppa
Dry lit
Not given
0.22 tor- 0.13 ppm
dry Hi
(NEXT PAGE)
GEBEBAL IHFORHATION
a) Noraal healthy Ben
b) chroaiuB plating worker
c) chroaate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JAPAN; ADULTS; AOTOPSIES; IDEEN1L
GUHDS; AORTA; BONES; BEABT;
INTESTINES; KIDNEIS; IIYEE; LOBGS;
LTIBPH HODES; PiNCEEHS; SPLEES;
STOHSCH; THySOID GLANDS; TEACHEl;
AIOHINOH: BARinn: CADHIOII; CALCIOI;
CBBOBIOB; COB1LT; COPPER; IRON; 1E»D;
niGNESinn; BAHGAHESE; METALS;
BOLYBDEIiOB; NICKEL; PHOSPHOBOS;
POTiSSIOH: SILICON; SILVER; SODIOB;
STBOBTI0H; UN; TIIlNIOfl; VAM1DIUH:
ZINC; BIOACCOBOLITIOH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONSBE; ZIBCONIDH; ELEBENTS
Range of Beans, estiaated froB graph
Aswan, El Kharga, Assuit, Cairo, and
Alexandria, Egypt
EGYPT; HAIR; BAILS; ANTIBOHT;
CADnlOM; CES10B; CHRORIOH; COBALT;
IKON; BANGANESE; BETALS; BOLYBDEHUB;
SC1NDIDR; SEIEBIOB; SILVER; TDNGSTEH;
ZINC; DBINKING HATER; POPOLATION
EXPOSURE; SOILS; ORBAS AREAS
Noraal tissue
Autopsies
Japan
JAPAB; ADULTS; AUTOPSIES; ADBEBAL
GLANDS; AORTA; BONES; HEABT;
INTESTIHES; KIDNEYS; LIVER; LDBGS;
LYHPH NODES; PANCREAS; SPLEEN;
STOHACB; THYROID GLANDS; TRACHEA;
ALUKINUn; BARIUB; CADHIUH; CALCIUd;
CHBOBIDB; COBALT; COPPER; IRON: LEAD;
DAGBESIUB; BANGANESE; BETALS;
BOLYBDENOB; NICKEL; PHOSPHOBDS;
POTASSIOB; SILICON; SILVER I SODMS;
STRONTIDB; TIN; TITANIUB; VANADIUB;
ZINC; BIOACCUBOLATIOB; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIBCOBIOH; ELEBENTS
Teraoka, H.
1931
Archives of
Environaental Health
36(1): 155-165
Kasperek, K.
lyengar, G.v.
Feinendegen, L.E.
Hashish, S.
Bahfouz, fl.
1982
Science of the Total
Environaent 22:149-168
00
Teraoka, H.
1981
Archives of
Environnental Health
36(4) : 155-165
-------
Iclybdenum
7439-98-7
no
At« 95.94, 8P 2622 C, BP 482S C (approx) . VP 1 >• Hg at 3300 C. 10 » Hg at 3770 C
(CONTINUED)
TISSUE
6601
Spleen
6602
Stomach
6603
Thyroid
glaal
EXPOSURE ROUTE
_
ANALYTICAL
RETROD
BS
ES
ES
- -
HURBEB
OF CASES
a) 9
b) 2
0 3
d| 1
e) 1
10
II
EillGE
a) Hot given
b) <0.2-1.2 ppm
c) <0.2-0.28 ppm
d) Mot applicable
e) Hot applicable
Dry lit
Hot given
Not given
HEAD
a) <0.2 pp«
b) Not given
c) Hot given
d) <0.2 pp«
e) <0.2 ppm
Dry «t
<0.2 ppm dry ut
<0.2 ppm dry vt
GEHEBAL INFORRATIOH
a) Normal healthy men
b) Chromium plating workers
c) Chcomate refining nortecs
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN: ADOLTS; AUTOPSIES; ADBENA1
GLANDS; AOBTA; BOXES; HEART;
IHTESTIHES; KIDNEYS; L1VEB: LUNGS;
IIBPH HODES; PtHCBEAS; SPLIEH;
STOHACH; THTBOID SLAHDS; TBACHEA;
AIDBIHUR; BAEIOB; CADfllOn; CiLCIOB;
CBTOBIBB! COBill! COPPER; IROH; IEAD:
HAGNESIDd; 8AHGAHESE; 8ETALS;
BOLTBDEHOH; NICKEL; PHOSPHOBHS;
pOTASsina: SIUCOH; SIIVEB; SODIOB;
STBO1III01); TH; TITAHIOH; VAHADIttH;
ZIKC; BIOACCDHOtATIOH; HEALTH
HAZABDS; OCCUPATIONAL KAZABDS;
TONGUE; ZIRCONinn; ELEMENTS
normal tissue
Autopsies
Japan
JAPAR; ADOLTS; AUTOPSIES; AOBEHAL
GLAHDS; AOBTA; BODES; HEART;
IHTESTIHES; KIDHEYS; LI VIE ; LOHSS;
LTHPH NODES; PAHCBEAS; SPLEEH;
STOHACH; THTROID GLANDS; TBACHEA;
ALOHIIDH; BARIUM; CADntOB; CALCIDR;
CB30BIOB; COBALT; COPPEB; IHOH; LEAD;
BAGHESIDH; HAHGAHESE; HETALS;
SOlTBDENOn; NICKEL; PROSPBOBDS;
PCTASSinR; SILICOH; SILVEB ; SODIOR ;
SIBONTIOR; TIN; TITAHIOn; VAHADIH9;
ZIHC; BIOACCOHOLATION; HEALTH
HAZARDS; OCCUPATIONAL RAZABDS;
TOHGOE; ZIRCOHIUfl; ELEDEHTS
Hormal tissue
Antopsies
Japan
JAPAN; ADULTS; AUTOPSIES; JDREKAL
GLANDS; AOBTA: BOHES; HEABT;
IBTESTINES; BIDNEIS ; LtTEB ; LOBGS;
LTBPH NODES; PANCREAS; SPLEEH;
STOHACH; THIROID GLANDS; TBACHEA;
ALOHIHUK; BABIUH; CADfllnH; CALCIUM ;
CBBORIHH; COBALT; COPPEB; IBOH; LEAD;
HAGNESIUH; 91HGAHESE; BETALS;
BOLTBDEHUR; NICKEL; PHOSPROBDS;
POTASSIUH; SILICOH; SIMEB; SODIDR;
STBOHTIUHi TIN; TITANIUR; YANADIOB;
ZINC; BIOACCUaULATION; HEALTH
HAZABDS; OCCUPATIONAL HAZABDS;
TOKGUE; ZIBCOHIOH; ELE8EHTS
BEFEBENCE
Teraoka , H.
1981
Archives of
Environmental Health
36(4) : 155-165
Teraoka • H.
1981
Archives of
Environmental Health
36(1) : 155-165
Teraoka, H.
1981
Archives of
36 (4): 155- 165
(KBIT PAGE)
00
00
-------
Bclybdenna
7»39-98-7
Ho
AtH 95.91, DC 2622 C, BP »825 c (approz) . VP 1 •• Hg it 3300 C. 10 » Hg at 3770 C
(CONTINUED)
660H
Tongue
6605
Trachea
EXPOSURE ROUTE
LITIC1L
ETHOD
BOBBER
OP CASES
2
2
RANGE
Hot given
Not given
BEAN
<0.2 pp. dry ut
<0.2 pp. dry Ht
Moraa]
Antop
Japan
JAPAN
GLAND
1NTES1
LTBPH
STOBi
ALUHI
CBROH
BAGNE
BOLTS
POMS
STRON1
BAZAR
TONGU
Nor.a
Autop
Japan
JAPAN
GLAND
INTES1
LYBPH
STOf!A(
ALUBI1
CHROB1
BAGNE
BOLYB
POTAS.
STRON"
HAIAR!
TONGU
GESEBAL I»?OBB«TIO»
JAP»»; ADULTS; ADTOFSIES; 1DHEKAL
GLANDS; AOBTA; BOMBS; BEAJ3T;
IITTESTINES; KIDHETS; LITI8; LONGS;
LTBPH NODES; PANCREAS; SPLEEN;
STOHACH: TH1HOID GLiSDS; TBACHEA;
; BAHIOH; CADBIOB; CALCIOB;
CBB01HOH; COBALT; COPPER; IRON: LEAD;
(1AGNESIOK; BAHGANESE; HZTALS;
BOLTBDENDH; NICKEL; PHOSP90SOS;
; SILICON; SILVER; SODIOI!;
STRONTIOH; TIN; TIT1NIUB; TANADIOB;
; BIOACCBHOLATIOS; HEALTH
BAZARDS; OCCUPATIONAL HAZARDS;
TONGDE: ZIRCONIDH; ELEMENTS
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LYIIPH NODES; PANCREAS; SPLEEN;
STOBACH; THtROID GLANDS; TRACHEA;
ALUBINDK; BARIUH; C4DHIOB; CALCIDB;
CHROBIUB; COBALT: COPPER; IRON; LEAD;
BAGNESIOB; IIANGANESE; 9ETALS;
BOLIBDENUB; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON; SILVEH; SODIUH;
STRONTIUB; TIN; TITANIUB; VANADIUB;
; BIOACCOBCTLATION; BEA LT»
BAIARDS; OCCDPATIOSAL HAZARDS;
TONGUE; ZIRCONIUB; ELEBENTS
Tecao)car H.
1981
Archives of
Environmental Healtt
36(») : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36 (It) .-155-165
00
Naphthalene
91-20-3
C10-HB
B» 128.16. BP 80.1 C. BP 217.9 C, VP 1 H Hg at 52.6 C
TISSUE
6606
Breath
EIPOSURE ROUTE
ANALYTICAL
BETHOD
GC/BS
NUBBER
OF CASES
28
EABGE
0.4-2.5 ng/1
9EAN
0.9 ng/1
GENERAL INFORBATICN
Estimated froa graph
Healthy 18-60 rr oldsr nonsaokers.
Rigid protocol 111 days before and
during study to ainiaize nnaber and
aaonnt of exogeneous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COBPOUNDS; CHLOHOBHZENES
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claadlo, B. p. A.
1977
Journal of
chroaatographic Science
15:239-2111
-------
naphthalene, methyl-
1321-9H-K
C11-H10
MS 1»2, St -22 C, BP 2414.6 C
TISSUE
6607
Breath
EXPOSDBE BOUTB
. .
ANALYTICAL
BETHOD
SC/MS
'
ND9BER
OF CASES
28
BADGE
0.08-0.75 ng/1
KEAN
0.25 ng/1
GENERAL IHFOBBATION
Estimated froa graph
Healthy 18-60 yc olds, nonsnokers.
Rigid protocol m days before and
daring study to liniaize nuiber and
JrOLTS; BFEAT8; ALCOHOLS ; C81ORINE
ORGANIC COHPOUHDS; CHLOHOE ENZENES
.
REFERENCE
I
Krotoszynski, B.
Gabriel, 6.
O'Neill, H.
Claudio, H. P. A.
1977
Chronatographic Science
15:239-2»«
nickel
HltO-02-0
Hi
At» 58.71, HP 1055 C, BP 2837 C, VP 10 » Hg at 2090 C, 100 •• Bq at 2370 C
TISSUE
6608
Adrenal
gland
6609
Aorta
EJCPOSOBE BOOTE
AKAtrTIClL
HETHOD
ES
15
KOMBBB
OF CASES
7
7
XAKGE
Not given
_ -
Not given
HEAD *
0.66 +or- 0.36 ppa
dry «t
0.50 »or- 0.20 pp>
dry lit
GENEBAL IHFOBHATION
Nornal tissae
AMtopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBEHAt
GIAIIDS; AOBTA: BONES; HEART;
IBTESTISES; KIDHETS; LITER; LUKGS;
ITI-PH NODES; PABCBEJS: SPLEEN;
STOBJCH; TBYEOID GLANDS; THACBEA;
ALDBISOB; BABIUB; CADBIUH; CALCIOK;
CHnoaion; COBALT; COPPZB; IBON; LEAD;
HAGNESIDH; MANGANESE; NZTAIS;
BOLIBDENOn; NICKEL; PH05PHOSDS;
POTASSIOH; SILICON; SILVER; SODIOH;
STHONTIOB; TIN; TITiNIOH; VANADIOB;
ZINC; BIOACCOBDLATIOS; HES1TB
RAZABDS; OCCOPATIONAL HAZARDS;
TONGUE; ZIHCONIOH; ELE9ENTS
Norial tissae
Autopsies
Japan
JAPAN; ADULTS: AUTOPSIES; ADBENAL
GU8DS; AOBTA; BONES; HEART;
INTESTINES; KID BETS: LITER; LUNGS;
LYBPH NODES; PAHCEEAS; SPLEEN;
STOHACH; THYROID GLANDS; TBACHEA!
ALORINUK; BARIOH; CADBIDB; CALCIUS ;
CBROSIUfl; COBALT; COPPER; IBON; LEAD:
aAGNESlnft; SASOABESB; HETALS;
ROLTBDENUH; NICKEL; PHOSPHORUS;
POTASSIUH; SILICON: SILTER ; SODIUB;
STRONTIUn; TIN; TITkNIUH; TANADIUH;
ZINC; BIOACCUanLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOIGDE; ZIBCONIDH; ELEMENTS
BEFE8BNCE
Teraoka, H.
1981
Archives of
Environaental Health
36(») : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(1) 5155-165
(NEI1 PAGE)
-------
nickel
HlW-02-0
Si
its 58.71, IIP 1055 C, EP 2837 c, VP 10 H Bg at 2090 C, 100 •• Hg at 2370 C
(CONTINUED)
TISSUE
6610
Bone
6611
Heart
6612
Intestine
EXPOSURE BOOTH
ANALYTICAL
BETHOC
ES
ES
ES
HOBBEE
01 CASES
5
, .
a) 8
b| 2
c) 3
4) 1
e) 1
10
BiHGE
Not given
_
a) Not given
b) 0.71-1.1 ppi
c) 0.27-12 pp«
d) got applicable
e) Not applicable
Dry wt
Hot given
BEAN
«I.O pp« dry wt
a) 0.43 *or- 0.23 ppa
b) 0.90 ppn
c) 4.22 pp«
d) 0.92 PP«
e) 0.29 pp«
Dry wt
0.51 +or- 0.18 ppm
dry »t
GENERAL INFOBBATION
Norial tissue
Autopsies
Japan
JAI>AH: A001TS; AUTOPSIES: ADBEKtL
GLANDS; JOBTA; BOBES; HEABT;
INTESTINES; KIDNEYS; LIVES; LUNGS;
LYBPH NODES: PANCEEiS; SPLEEN;
STOBACH; THYBOID GLANDS; THACREA;
ALDRINJK; B1EIOH; CiDBIUB; CALCIOn;
CBEOBIOB; COBALT: COPPEB; IRON; LEAD;
BASNESIDB; HANGANESE; BETALS;
BOLYBDENafl; NICKEL; PBOSPB080S;
POTASSIOII: snicoN; SILTEE; soorra;
STEOHTIOB; TIN; TITANinB; TANADIUB;
ZINC; BIOACCDBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
; IIBCOHIUR; ELEBEHTS
a) Norial healthy ten
b) chroniuB plating workers
c) chronate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JAPAN: ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; BEAUT;
INTESTINES; KIDNEYS; LITEB: LUNGS;
LYMPH NODES; PANCEEAS; SPLEEN;
STOMACH; THYROID GLANDS; TBACBEA;
ALCBINUB; BABIUB; CADBIDB; CALCIUB;
CBBOBIUB; COBALT; COPPEE; IBON; LEAD;
BAGNESIUH; KANGANESE; BETALS;
BOLYBDENUB; NICKEL; PHOSPBOBOS;
POTASSIDB; SILICON; SILVER; SODHB;
SIBONTIUB; TIN; TITANIOB; VANADIDB;
ZINC; BIOACCOBULATION; HEALTB
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE: ZIRCONIBB; ELEBENTS
Nonal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AOBTA; BOSBS; HEART;
INTESTINES; KIDNEYS; LIVES; LDNSS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYBOID GLANDS; TBACHEA;
ALUBINDH; BABIUfl; CADBIDB; CALCIUB;
CHBOHIOB; COBALT; COPPER; IBON; LEAD;
BAGNESIDB; BANGANESE; BETALS;
BOLYBDESUB; NICKEL; PHOSPHOBUS;
POTASSIOB; SILICON; SILVER: SODIOB;
ST50NTIUB; TIN: TITANIDB; VANADIUB;
ZINC; BIOACCDBULATION; HEALTH
HAZARDS; OCCUPATIONAL BAZABDS;
TONGUE; ZIBCOSIUB; ELEBEHTS
(NEXT PAGE)
Teraoka, H.
1981
Archives of
Environmental Health
36(0):155-165
Teraoka, H.
1981
Archives of
Environoental Health
36(1) :155-165
Teraoka. H.
1981
Archives of
Environnental Health
36(»):155-165
-------
nickel
I "490-02-0
Hi
At» 58.71,
HP 1S55 C, BP 2837 C, VP 10
Hg at 2090 C. 100 •• Hg at 2370 C
(CONTINUED)
TISSUE
6613
Kidney
661U
Liver
6615
lirer
1
1
EXPOSOBE BOOTE
_
AHALYTICAL
METHOD
ES
__
ES
.
1ST
1ST
» on BIS
OF CASES
a) 8
b) 2
0) 3
d) i
e) 1
a) 9
b) 2
c\ 3
d) 1
e) 1
30
BINGE
a) Hat given
b) 0. 55-1. 6 ppi
c) 0.22-100 ppi
e) Hot applicable
Dry ut
a) Hot given
b) 0.15-1.2 ppi
c) 0.3-34 ppi
d) Hot applicable
e) Hot applicable
Dry vt
.
0.009-0.32 ug/g
>et It
(HIZI
BEAU
a) 0.57 tor- 0.31 ppi
b) 1.1 pp.
c) 33.63 ppi
d) 1*6 ppi
e) 0.33 ppi
Dry »t
a) 0.33 «or- 0. 13 ppi
b) 0.82 ppi
c) 11.9 ppi
d) 2. « ppi
e) 0.36 ppi
Dry vt
Hot given
PAGE)
GESESAL UFOBBATIOH
a) Honal healthy ien
b) Chcoiiai plating workers
c) Chroiate refining vockets
d) tirplane paintec
e) Stone lason
Autopsies
Japan
J1PAH; tDDlTS; AUTOPSIES; IDBESM.
GLMDS; AOBTA; BOHES; HEtBT;
UTESTINES; KIDIETS ; LITEB ; 1DNGS;
LIBPR NODES: PAUCBEAS; SPLZER;
STOIllCH; TBIROID GLIHOS; TBICSEA;
alORIHun; B4BID1I; CADBIOB; CalCIon;
CBBOBIDR; COBALT; COPPER; IRON: LEAD;
HAGNESItffl; 8AHGAHESE; HXTALS;
flOlTBDEHDfl; HICK EL; PBOSPDOBOS;
POTASSIOH; SILICOH; SIITEB; SOBIOB ;
STBOHTIOB; TI»: TITAHIOn; TAHADIQH;
ZIHC; BIOACCOBULATIOH; HEALTH
BAZABDS; OCCOPATIOHAL BJIABDS;
TOH6DE; ZIBCOIIDH; ELE BESTS
a) Nocial healthy ien
b) chroiini plating workers
c) Chroiate refining vorkecs
d) Airplane painter
e) stone lason
Autopsies
Japan
JAPAH; ADULTS; AUTOPSIES; ADBEJAL
GLAH9S; AOBfA; BOHES; BEABT;
miSTimS; KIDIEIS; ITTEB; LOUGS;
LIBPH HODES; PAHCBEAS; SPLEEH;
STOHACH; THTBOID GLAHDS; TBACHEA;
ALOBIHOH; B4BIOB; CADBItJB; CALCHIB;
CEBOHIOB; COBALT; COPPER; I BOH: LEAD;
BAGSESIOB; KAHGAHESE; BEIAtS;
BOITBDEHDB; HICKEL; PHOSPBOBUS;
POTASSIOR; SILICOH; SILTEB; SODIOB ;
STBOSTIOB; TIM; TITABIOS; TAHADIDH;
ZIK; 3IOACCOBOLATI09; HEALTH
BAZABDS; OCCOPATIOIAL HAZARDS;
TOHGOE; ZIBCOHIUH; ELEBEIITS
Category 1 (first priori t eleient)
as proposed by International Workshop
on Honitoring Environmental Haterials
and Speciien Banking
Autopsies, Baltimore, HD,
Hinneapolis, BI, and Seattle, !A
BABTLAHD; HIIHESOTA; HASHIHGTOH;
urtopsiEsj LiTia; HEASDBEBEUT
BITHODS; ALOBIHOB; AHTIHOHT; AESEBIC;
EABIVR; CADBIUB; CHBOBUJB; COBALT;
COPPEt; FLDOBI1E; IBO»; LEAD;
OARGAHESE; 8EBCOBI; HOLTBDEHOH;
HICKEL; BOBIDIUB; SELE1IOB; SILTES ;
STBOHTIOH; TBALLlni: TIH; TAHADIDH;
ZIHC; POPITLATIOH EIPOSOBE
BEFEBESCE
Teraoka, H.
1981
Archives of
36(«) : 155-1 65
Teraoka , B.
1981
Archives of
Environmental Health
36(») ;155-165
Harrison, S.H.
Zeisler. It.
Vise, S.A.
1981
EPA 600/S1-81-025, 6
pp.
VO
-------
Hickel
7440-02-0
Si
it» 58.71.
6616
Lung
1455 C, BP 2837 C, TP 10 » Hg at 2090 C, 100 •• Bg at 2370 C
(CONTINUED)
6617
Ly.ph
node
6618
Pancreas
EXIOSOBE SODTE
A1AMTICAL
BETBOD
HUBBEB
OF CASES
a) 12
b) 2
C) 3
d) 1
e) 1
a) 3
b] 1
cl 3
d) 1
e| 1
5
BARGE
a) Not giyen
b) 4.1-4.5 pp«
c) 1.0-9.4 PPB
d) Hot applicable
e) Hot applicable
Dry wt
a) Hot given
b) Hot applicable
c) 1.1-13 ppa
d) Not applicable
e) Hot applicable
Dry vt
Hot given
HE AH
a) 0.73 +or- 0.33 PPB
b) 4.3 PPB
c) 4.2 pp»
d) 2.6 ppB
e) 1.0 ppM
Dry »t
a) 3.7 +or- 3.4 ppB
b) 7. 0 PPB
c) 8. 1 pp»
d) 4.1 ppB
e) 1.7 pp«
Dry lit
0.27 +or- 0.07 ppa
dry lit
GE»EBAL IIFOHBiTIOI
a) normal healthy Ben
b) ChroaiuB plating workers
c) cbroiate refining workers
d) iirplane painter
e) Stone Bason
autopsies
Japan
J»PA»; i DOITS; iOTOPSIES; tOBBNAL
GLJBD3; 10BTA; BOIES; HB»RT;
IITESTIKES; KIDBETS; LIVES; LOHGS;
ITIIPH NODES: P1MCBEJS; SPLEEH;
STOBJCH; TBIDOID GLllDS; TB1CHEJ;
llORTKra; ElHtai; CADHIOH; OLCIOH;
CHSOBinn; COBALT: COPPER; IBO»: LEAD;
BAGMESIOB; ailGHESE; BEIALS;
BOlIBDENOn; NICKEL; PHOSPBOBOS;
POTaSSIDH; SI1ICOB; SILTEB ; SODIOS;
S1BOITIUH; TI»; TIT A HI OB; TtHaDlnR;
tISC; BIOACCOnDLJTIOH; BEA1TB
HlfABDS; OCCDP1TIOI1L HIZaBDS;
TOUGnE; ZIRCOmtJfl: ELEHEITS
a) Horaal healthy Ben
b) Chro«iai plating worker
c) Chrosate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JifAS; ADOLTS; AOTOPSIES; ADEEJAL
GLANDS; AOBTA; BOMBS; BEAET;
IVTESTIHES; KIDNEYS; LIfEB; LDKGS;
ITBPR NODES; PANCfiEAS; SPLEEI;
STOBACH; THTBOIO CLAUDS; TRACHEA;
ALOHINHB; BABInB; CADHIDD; CALCIOB;
CBSOBIOB; COBALT; COPPER; IBOH; LEAD;
BAGHE3IUS; RARGA1ESE; HETALS;
BOLIBDESOn; NICKEL; PHOSPHORUS;
POTHSSIOB; 3IIICOH; SILTEB; SODIOB ;
S1BOITIDB; TIR; TIT A »I OB; fANADIHS;
ZIBC; BIOACC080LATIOM; BIALTB
HAZARDS; OCCOPATION AL BAZABDS;
TONGUE; ZIBCOIIDB: ELEHEITS
Horaal tissue
Autopsies
Japan
JAPAN; ADDLTS; AOTOPSIES; ADRENAL
GLASDS; AOBTA; BOHES; HEART;
IHTESTISES; KIDHETS; LITER; LOMGS;
LTDPB NODES; PAHCBEAS; SPLEEI;
STOBACH; THYROID GLANDS; TRACHEA;
ALOBIHtFH; BARIiJH; CADHIUB; CALCIOB:
CBROBIOB; COBALT; COPFEB; IRO»; LEAD;
BAGSE5ITIS; HABGA1ESE; BETALS;
BOLTBDENOB; HICKEL; PHOSPHOROS;
POTASSIOB; SILICON; SILTEB; SODIOB;
STRONTIOB; Til; TITASIOB; IHIDIOB;
ZINC; BIOACCOBOLATION; HEALTH
BAZABDS; OCCOPATIOHAL BAZABDS;
TOUGDE; ZIBCONIOB; ELEHEITS
-
REFEEEHCE
Teraoka* H.
1981
Archives of
Environaental Bealth
36(4) : 155-165
Teraoka, H.
1981
Archives of
36(«|J'55-I65
Teraoka, H.
1981
Arch ires of
SnrironBental Health
36(4):155-165
(NEXT PAGE)
-------
nickel
•7440-02-0
II
lt» 58.71,
BP 1*455 c, Bf 2837 C. VP 10 •• Bg at 2090 C. 100 II Hg at 2370 C
(CONTINUED)
TISSUE
6619
Spleen
6620
Stoiach
6621
Thyroid
gland
EXPOStTBE 800TE
ANALYTICAL
METHOD
ES
IS
ES
HUBBEB
OF OSES
a) 9
b| 2
c) 3
d) 1
el 1
10
11
BINGE
a) Hot given
b) 0.20*2.5 pp»
c) 0.20-31 pp»
d) Not applicable
e) Not applicable
Dry ut
Hot given
Not given
BEAN
a) O.H2 *or- 0.21 ppn
b) l.il ppm
c) 11.5 ppm
d) 2.4 pp.
e) 0.55 ppm
Dry wt
0.51 «or- 0.18 pp»
dry wt
0.43 +or- 0.27 pp»
dry wt
GENERAL INFOBBATION
a) Nornal healthy men
b) ChroBiua plating workers
c) chronate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADEENiL
61ANDS; AOSTA; BONES; BEABT;
INTESTINES; KIDNEYS; IIVER; 1UNGS;
IYBPH NODES; PANCBEAS; SPLEEN;
STOHACB; THTBOID GllHDS; TRACHEA;
ALUBIHUB; BABIUB; CADBIUH; CA1C10I1 ;
CHEOnlOB; COBALT; COPPER; IBOH; LEAD;
DAGNESIUII; HANGANESE; BETSIS;
HOLTBDENUH; SICKEL: PHOSPHORDS;
POTASSIDH; SILICON: SILVER; SODIUS;
ST50NTI09; TIB; TITABIOB; TANADIOB;
ZINC; BIOACCtlBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGUE; ZIBCOBIUH; ELEMENTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUHGS;
LTBPH NODES; PANCBEAS; SPLEEN;
5TOBACH; THYROID GLANDS; TRACHEA;
AlUBINUB; BARIUB; CADBIDH; CALCIUB;
CBBOBIUB; COBALT; COPPEB; IRON; LEAD;
HAGNESIUB; MANGANESE; DETALS;
BCLTBDEBUB; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON; SILVER; SODIUB;
S1BONTIUB; TIN; TIT* SI n«; VANADIUB;
ZINC; BIOACCDBULATION; HEALTH
BAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUM; ELEMENTS
Ronal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEABT;
INTESTINES; KIDNETS; LIVER; LUNGS;
LIBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TBACHEA;
AUHfisun; Basion; CADHIOH; CAICIUB;
C HBO BIO B ; COBALT; COPPEB; IRON; LEAD;
HAGNESIUB; HANGANESE; METALS;
BOLTBDENOB; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON; SILVEB; SODIUM;
STRONTIUM; TIN; TITANIDB; VANADIUM;
ZINC; BIOACCOBULATION; HZALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TONGUE; ZI8CONIOB; ELEMENTS
REFERENCE
Teraoka, H.
1981
Archives of
Environnental Health
36 (4): 155-165
Teraoka, H.
1931
Archives of
Environnental Health
36(4):155-165
Teraoka, B.
1981
Archives of
Environmental Health
36(4):155-165
(MBIT P1GE) ^
VO
-------
Nickel
7«ao-02-o
>i
Atw 58.71, DP 1*55 C, BP 2837 C, »P 10 >• Hg at 2090 C, 100 BB Hg at 2370 C
(CONTINUED)
1 TISSUE
6622
Tongue
6623
Trachea
6624
Urine
EIPOSORE ROOtE
Inhalation
A8AIYTICAL
BET BOD
ES
IS
BOBBER
OF C1SE5
2
2
al 1}
I 'J
b| 7
a 9
d» 7
e) m
fl «
g) 1«
h| 15
i) 83
BIHGE
Mot given
Not given
a) —6 ug/1
b) -6 ug/1
c) -5 ug/1
d) -18 ug/1
e) _u ug/1
f) 2-9 ug/1
g) 2-10 ug/1
h) 2-14 ug/1
i) 1-18 ug/1
BEAU
0.10 »or- 0.02 PPB
dry wt
0.39 *or- 0.21 pp«
dry »t
b) 2.2 or- 1.9 ug/i
c) 2.0 or- 2.0 ug/1
a) 3.8 or- 3. 1 ug/1
e) 3.0 or— 2.5 ug/i.
f) 4.3 or- 2.9 ug/I
g) 3.2 or- 1.9 ug/1
h) 6.4 or- 1 .9 ug/1
i) 3.3 or- 2.2 ug/1
Geoaetric
GEHEBiL IHTOBBILTIOli
Nornal tissue
Autopsies
Japan
JAP1K; BDOLTS; AUTOPSIES; ADEESAL
GIANDS: AOBTA; BOKES; BEABT;
IHTESTIHES; KIDHEIS; 1I»EE; LOHGS;
LYHPH NODES; PAHCBEAS; SPLEEN;
STOBACH; THTROID GLANDS; TRACHEA;
ALODiNon: BABiaa; CAoniun; cALCinn;
CHBOBIUB; COBALT; COPPER; IRON; LEAD;
BAGNESIOB; BANGADESE; BETA IS;
BOIIBDENUB; BICKEL; PHOSPHOBOS;
POTASSIOB; SILICON: SILVER ; SODIOB ;
STRONTIOB; TIN; TITANIBB; VABADIHB;
ZINC; EIOACCOHOLATION: HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIOB; ELEHENTS
Nonal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLARDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LITER; LONGS;
LT.BPH NODES; PANCREAS; SPLEEN;
STOSACH; THYROID GLANDS; TRACHEA;
ALOfliimn: BABITJB; CADBIUB; CALCIOB;
CBROSIOH; COBALT; COPPER; IROS; LEAD;
HAGNESIUH; MANGANESE; HETALS;
BOLYBDENDB; NICKEL; PHOSPHORDS;
POTASSIUn; SILICON; SILVER; SODIOfl;
SIROSTIOH; TI»; TITANIOB: VAUADIUB;
ZINC; BIOACCUBULATIOH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUB; ELEHENTS
previous 10 yr spent in Manual netal
arc veiling (BHA) , nonsaolcers
b) Saae as a) , saokers
d) Sane as c) , siokers
e) 50-89H BHA welders, nonstokers
£) saae as e) , saokecs
g) > or = 90K BHA welders, nonsiokers
h) Saae as g) , sBokers
i) All sa spies
No correlation vith exposure level
Stainless steel welders, Finland
FIHLAHD; URINE: CHROBIHB; HETALS;
NICKEL; FOBBS; INDUSTRIAL PLANTS;
INDUSTRIES; OCCUPATIOHAL HAZARDS;
SBOKING
BEFERHHCE
Teraoka, R.
1981
Archives of
36(4): 155-165
Teraoka, H.
1961
Archives of
Environmental Health
36{«):155-165
Kallio naki, p. — L.
Rahkonen, E.
Yaaraoen, V.
Kalliomaki, K.
Aitt onifiBX K.
1981
International Archives
of Occupational and
Environmental Health
1(9:67-75
-------
Nicotine (8 CI)
Pyridine, 3-<1-«ethyl-2-pyErolidinyl)-. (S)- (9 CI)
54-11-5
C10-B14-H2
BB 162.23, HP < -80 C, BP 247 c (partial decoip) at 745 •> Sq, 123-125 C at 17 «« Hg, VP 1 in Hg at 61.8 C
TISSUE
6625
Orine
EXPOSOBB BOOTI
Inhalation
Denal
»»»LTTICil
HETHOD
811
SUB BEE
OF CASES
.
42
BtXSE
a) 0-41 ug/100 119
creatine
b) 2.6-293 ug/100 «g
reatine
) 9-67 ug/100 ig
reatine
c ) 0-102 ug/100 ig
reatine
) 0-7.9 ug/100 »g
reatine
f) 0-45 ug/100 14
creatine
g) Hot given
h> 0-6.4 ug/100 »J
creatine
a) 8.4 ug/100 ig
creatine
b) 89.0 ug/100 «g
creatine
) 12.7 ug/100 «g
reatine
} 22.5 ug/100 ag
reatine
2.6 ug/100 mg
reatine
£) 11.4 ug/100 19
creatine
g) 15 ug/100 ag
creatine
h) 3.2 ug/100 >g
ereastine
GEHEBiL IHFOEnHTIOM
a) 16 tobacco pickers, pre-exposure
b) 16 tobacco pickers, Morning after
8 hr harvest exposure
c) 10 tobacco stringers, pre-exposure
d) 10 tobacco stringers, Morning
after 8 hr harvest exposure
e) 6 tractor drivers, pre-exposure
f) 6 tractor drivers, Morning after 8
hr harvest exposure
g) 1 novice siokers, Horning after
sioking 3 cigarettes containing 1.3
•g nicotine each during 30 Bin,
estimated froa graph
b) 6 non-exposed controls
Heasured as continine, Metabolite
North Carolina tobacco faras where
green-tobacco sickness had occurred.
Median age of workers, 14 yr
Nausea and dizziness, 3 workers
AGRICOLTORE; FUBHS; (1ETHBOLITBS;
OCCUPATIONAL HiZiBDS; SWOKIHG;
TOBACCOS; NICOTI8E; OCCQPATIOKAL
DISEASES; OBINB; BOBTR CABOLIHA
Ge hi back, S.H.
Perry, L.D.
Hillians, »-A.
Freeman, J.I.
1975
Lancet 1(7905):478-480
Nanane
111-84-2
C9-H20
a« 128.25. HP -53.7 C, BP 150.7 C. VP 10 » Hg at 38.0 C
TISSDE | EXPOSOttE BOdlK
6626
Breath
»«»LTTICIL
BETBOD
I HdHBEE
1 OF CAS S3
28
ElBGE
0.27-2.4 ag/1
BEIK
0.8 ng/1
GEHIBiL IHfOEHlTIOK
Estiaatecl froi graph
Healthy 18-60 yr olds* nonsiokers.
Bigid protocol 14 days before and
during stadT to linirtze nuMber and
anount of exogeneous constituents.
» DOLTS; BBE1TH: 4ICOBOLS; CHLOEIHB
OEGiRIC COHPODRDS: CHIOBOBEHZEBES
PEFEEEHCE
Krotoszynski, B.
Gabriel, S.
O'seill, B.
Claudio, B. P. 1.
1977
Journal of
Chronatographic Science
15:239-244
0-Xil.ene (8 CI)
Benzene, 1,2-diiethyl- (9 CI)
95-47-6
C8-H10
B« 106.16, at -25 C, B! 144 C, T? 10 II Bg at 32.1 C
TISSOE
6627
Breath
EIPOSDBE BODTE
iniTTICU.
BETBOD
6C/8S
KDBBBB
OF OSES
28
sites
0.37-3.4 ng/1
-
BEAK
1.1 ng/1
EEIEBAL HFOBHATIOI
Estiiated froi graph
Healthy 18-60 yr olds, nonaiokers.
Bigid protocol 14 days before and
daring study to liniiize naiber and
aionnt of exogenous constituents.
1DULTS; BBEITB; 1LCOH015; CBL01IIE
08GARIC COHPODRDS: CHLOBOBEIZEIES
BEFEBEICE
Krotoszynski, B.
Gabriel, G.
O'Xeill. H.
Clandio, B.P.I.
1977
Journal of
Chroiatographic Science
15:239-24»
-------
Octane
111-65-9
C8-H18
B» 114.23, BP 56.8 C, BP 125.8 C, TP 10 »« Bg at 19.2 c
6628
Breath
EXPOSURE ROUTE
AIALTTICAL
BETHOD
GC/NS
SOB BEE
OP CASES
28
BINGE
0.055-0.49 ng/1
HEAD
0.16 ng/1
GENERAL MFOBBATION
Estimated fcoi graph
Healthy 18-60 yr olds, nonsmokers.
Bigid protocol 14 days before and
daring study to liniiize noiber and
aioant of exogenous constituents.
HOLTS; BREATH: ALCOHOLS; CHLOBINE
ORGANIC COBPOUNDS; CHLOROBENZENES
REFERENCE
Krotoszynski, B.
Gabriel, s.
O'Neill, H.
Claudio, H.P.I.
1977
Journal of
ChroBatographic Science
15:239-21»
p-Cresol, 2,6-dl-tert-butyl- (8 CI)
Phenol. 2,6-bis(1,1-dl«ethylethyl)-»-«ethyl- (9 CD
128-37-0
C15-H21-0
B» 220.3, IIP 70 C, BP 265 C
TISSUE | EXPOSURE ROUTE
I
6629
Breath
HULYTICJL
HETHOD
GC/HS
>0«BEB
OF CASES
28
B1HGE
0. 13-3.8 ng/1
BEAK
0.7 ng/1
GEIERAL IBFORKATIOB
Esti Bated froi graph
Healthy 18-60 yr olds, nonsiokers.
Rigid protocol 14 days before and
during study to Biniiize nuuber and
amount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLOBIHE
OBGAHIC COBPOUDDS; CRLOROBE«ZERES
REPEBEHCE
Krotoszynski, B.
Sabriel, G.
O'Neill, H.
Claudio, B.P.I.
1977
Journal of
ChroaatograpKic science
15:239-2111
p-Cy«en-7-ol (8 CI|
Benzeneiiethanol, U-(1-methylethyl) - (9 CI)
536-60-7
C10-H11-0
HW 150.22, BP 28 C, BP 249 C, VP 1 •• Hg at 74.2 C
TISSUE I EXPOSURE ROUTE
I
6630
Breath
AHALTTICAL
HETHOD
GC/BS
B DB BEE
OF CASES
28
RANGE
0.05-0.5 ng/1
HEAD
0.16 ng/1
GENERAL INFOBBATI01
EstiMated froa graph
during study to •iniaize nuiber and
aiount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COBPOUNDS; CHLOROBENZENES
REFERENCE
Kcotoszynski, B.
Gabriel, G.
O'Neill, H.
1977
Journal of
chronatographic Science
15:239-244
-------
p-»entha-1,8-diene (8 CI)
Cyclohexene, 1-methyl-
-------
Pentaner 2-aethyl-
107-83-5
C6-H11
US 86.16, HP -153.67 C, BP 514-60 C, VP 100 mm Hg at 8. 1 C
6634
Urine
EXPOSURE ROUTE
Inhalation
ANALYTIC*!
HETHOD
NUBBER
OF CASES
<0.1-5.15 mg/1
1. 28 mg/1
GENERAL IHFOBHATIOH
2-1ethyl-2-pentanol, metabolite of
2-methylpentane. Exposure, 11-250
mg/cu m {mean 77 ig/cu m) , commercial
hexane
Workers in shoe factories.
INDUSTRIAL CHEBICALS; IT1LY; ADULTS;
URINE; INDUSTRIAL AREAS; INHALATION;
BETABOLITES; OCCUPATIONAL HAZARDS;
SOLVENTS
REFEBEKCE
Perbellini, L.
Brugnone, F.
Faggionato, G.
1981
British Journal of
Industrial Bedicine
38:20-26
Pentane, 3-ethyl-
617-78-7
C7-H16
BK 100.21, BP -118.60» C, EP 93.5 C, VP 10 mm Hg at -6.8 C
TISSUE ~ EXEOSURE'BOUTEANALYTICAL NUBBEB"~~RANGEBEAN G!NERAL~iiiFOBBATio» REFERENCE"
BETHOD OF CASES
6635 GC/BS 28 0.12-1.0 ng/1 0.33 ng/1 Estimated from graph Krotoszynski, B.
Breath Gabriel, G.
Healthy 18-60 yr olds, nonsmokers. o'Heill, H.
Bigid protocol 114 days before and claudio, B.P.A.
during study to minimize number and 1977
amount of exogenous constituents. Journal of
Chromatographic science
ADULTS; BREATH; ALCOHOLS; CHLORINE 15:239-2114
OEGASIC COBtOOKDS; CHLOROBENZENES
Pentane, 3-methyl-
96-114-0
C6-H14
B» 86.17, BP 63.3 C, VP 100 mm Hg at 10.5 C
TISSUE EXc6snSE~im>TE ANALYTICAL NUB BEE BANSE BEAN 7 GS"5EEAL~IBFOEBATION
BETHOD OF CASES |
6636 Inhalation GC HI <0.1-1.0 mg/1 0.16 «g/l 3-Bethyl-2-pentanol, metabolite of Perbellini, L.
Urine 3-methylpentane. Exposure, 10-204 Brugnone, F.
mg/cu m (mean 63 mg/cu m), comnercial Fagqionato, G.
hexane 1981
British Journal of
Workers in shoe factories. Industrial Medicine
38:20-26
INDUSTRIAL CHEBICALS; ITALY; ADULTS;
URINE: INDUSTRIAL AREAS; INHALATION;
BETABOLITES; OCCUPATIONAL HAZAEDS;
SOLVENTS
-------
Pentanoic acid, 2-aethyl-, ethyl ester
39255-32-8
C8-H16-02
Hi 144.211
6637
Breath
EXPOSURE ROUTE
GC/HS
C1L
D
HUB BEE
OF CASES
28
RANGE
0.03-0.22 ng/1
HEAN
0.08 ng/1
GENERAL INFORS1TION
Estimated f£OB graph
Healthy 18-60 yr olds, nonsiokers.
Rigid protocol 14 days before and
during study to liniaize nuiber and
anonnt of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COBPOBNDS; CHLOROBENZENES
Krotoszynski, B.
Gabriel, G.
O'Heill, H.
Claudio, a. P. t.
1977
Journal of
Chroaatographic Science
15:239-244
Eentyl alcohol (8 CI)
1-Pentanol (9 CI)
71-41-0
C5-H12-0
18 88.1, HP -79 C, BP 137.8 C, VP 1 •• Eg at 13.6 C, 10 •• Bg at 44.9 C
TISSUE
6638
Breath
EXPOSURE ROUTE
AHALTTICAL
METHOD
GC/HS
11 08 8F.fi
OF CASES
28
RADGE
0.2-3 ag/1
HSAN
0.75 ng/1
GENERAL INFORSATION
Estimated froi graph
Healthy 18-60 yr olds, nonsiokers.
Rigid protocol 14 days before and
during study to liniaize nnaber and
aiount of eiogenous constituents.
ADOLTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COHPOUNDS; CHLOROBENZBNES
Krotoszynski, B.
Gabriel, G.
O'Neill. H.
Claudio. H.P.A.
1977
Journal of
Chroaatographic Science
15:239-244
O
O
Phenol
108-95-2
C6-H6-0
US 94.11. HC 40.85 c, BP 182 C, VP 1 •• 89 at 40.1 C
TISSUE
6639
Skin
EXPOSURE ROUTE
.
Berial
ABALITICAL
BETBOD
- - -
IUHBEB
OF CASES
12
RANGE
a) lot given
b) lot giTen
c) lot given
d) lot given
e) Not given
HEAN
a), 0.391 tor- 0.118
«g
b) 0.632 tor- 0.219
»g
c) 1.136 tor- 0.350
•9
d) 1.44 tor- 0.37 ig
e) 2.4 tor- 0.38 ig
GEIERAL INFOFRATION
a) 7.6* of dose absorbed after IS «in
exposure of 2.5 q/i on 15.9 sq cm.
Atsorption rate 0.098 tor- 0.029
•g/sg CM/hr
b) 12.6* of dose absorbed after 30
rate 0.079 tor- 0.026 ig/sq ci/hr
c) 22.7% of dose absorbed after 60
•in exposure as in a) . Absorption
rate 0.080 tor- 0.026 ftg/sq ci/hr
d) 14. 4* of dose absorbed after 30
•in exposure to 5.0 g/1 on 15.9 sg
CM. Absorption rate 0.181 tor- 0.047
•g/sg. o/hr
e) 12. OX of dose absorbed after 30
•in 'exposure to 10 g/1 on 15.9 sq CM.
Absorption rate 0.301 tor- 0.048
•g/sg c*/hr
20-42 yr olds
ORINE; PHENOLS; IIDOSTBIAL CHEHICALS;
SOLVENTS
REFERENCE
Bara no wska-Dut ki evicz ,
B.
1981
International Archives
of Occupational and
Envi roniental Health
49:99-104
(•BIT PASK)
-------
Phenol
108-95-2
C6-H6-0
HI 9H.11, HP DO.85 C, BP 182 C. VP 1 II Hg at 40.1 C
(CONTINUED)
TISSUE
Urine
6641
Drlne
EIPOSORB ROUTE
ANALYTICAL
BEIHOD
IUBBEB
OF C1SES
12
639
EANGE
-
a) 10-15 mg
b) 21-30 ig
c) 28-42 mg
4) 3
-------
Phenol, pentachloro-
81-86-5
ce-H-C15-0
HW 266.35, DP 190-191 C, BP 309-310 C (decomp) , TP 10 M Hcj at 211.2 C
TISSOE
66 «2
Adipose
6613
Blood
6644
Grain
6615
Kidney
6616
Liver
EXPOSURE SODTE
ANALYTICAL
BETHOD
.
GC
GC
GC
GC
GC
NUHBEB
OF CASES
21
21
21
21
21
BINGE
Mot given
5-69 ng/nl
Not given
Not given
-
Not given
HEAI
It. 18 ng/g
26.03 ng/»l
49.14 ng/g
64. 14 ng/g
86.0 ng/g
GENERAL INFOBHATION
5 and 95 peccentiles, 10.00 and 22.45
ng/g. Median 12.67 ng/g. Autopsy
data
Northern Bavaria
GEBBANY; AOIOPSIES: ADIPOSE TISSOE:
UJINE; PESTACBLOEOPHENOL
Detection limit 5 ng/al
Autopsy data
GEEHAHY; AUTOPSIES; ADIPOSE TISSUE;
E100D; BBAIN: KIDNEYS; LIVEB; SPLEEN;
UBINE; PENTACHLOEOPHENOL
5 and 95 percentiles 19.00 and 72.45
ng/g. Median 47.00 ng/g. Autopsy
data.
GEBKANY; AUTOPSIES; ADIPOSE TISSUE;
BLOOD; BHAIS; KIDNEYS; LIVES; SPLEEN;
ORINE; PEHTACHLOBOPHENOL
5 and 95 percentiles. 24.00 and 94.95
ng/g. Hedian 43.00 ng/g. Autopsy
data.
Northern Bavaria
GEEHANY; AUTOPSIES; ADIPOSE TISSUE:
USISE; PEHTACHLOBOPHENOL
5 and 95 percentiles 17.00 and 173.45
ng/g. Redian 67.00 ng/g. Autopsy
data
Northern Bavaria
GEEHANY; AUTOPSIES; ADIPOSE TISSUE;
BLOOD; BBAIN; KIDNEYS; LIVES; SPLEEN;
UKINE; PEKTACHLOBOPBEDOL
BEFEEENCE
Grin, B.-G.
Schellnann, B.
Schaller, K.-H.
Gossler, K.
1981
Zentralblatt fuer
Bakteriologie,
Infektionskrankheiten
und Hygiene, Abteilung
1. Originate. Eeihe B
174:77-90
Gri», H.-G.
Schelliano, B.
Schaller. K.-H.
1981
Zentralblatt fuer
Bakteriologie,
Parasitenkunde ,
Infektionskrankheiten
und Hygiene, Abteilung
1. Originals, Eeihe B
174:77-90
Grimm, B.-G.
Schelliann, B.
Schaller, K.-H.
Gossler, K.
Zentralblatt fuer
Bakteriologie,
Parasi tenkunde ,
Infektionskrankheiten
und Hygiene. Abteiluug
1. Oriqinale, Beihe B
174:77-90
Grin, H.-G.
Schelliann, B.
Schaller, K.-H.
Gossler, K.
1981
Zentralblatt fuer
Bakteriologie,
Infektionskrankheiten
und Hygiene, Abteilung
1. Originale, Beihe B
174:77-90
Grimm, H.-G.
Schellaann, B.
Schaller, K.-H.
Gossler, K-
1981
Zentralblatt fuer
Bakteriologie,
Parasi tenkunde,
Infektionskrankheiten
und Hygiene, Abteilung
1. Originale. Beihe B
174:77-90
(NEXT JAGE)
O
K3
-------
Phenol, pentachloro-
87-86-5
C6-H-C15-0
BB 266.35, IIP 190-191 C, BP 309-310 C (decoip) , 7P 40 u Hg at 211.2 C
(CONTINUED)
6647
Spleen
6648
Orine
6649
Orine
EXPOSORE ROTJ1E
IBILITICH
BETHOD
GC
GC
HDBB2B
or CISES
21
21
B1HGB
Not given
a) 150-2700 ug/g
creatinine
c) 340-3400 ppb
fl) 32-HOO ppb
e) 0-31 ppb
1-260 ng/»l
BZ1»
20.76 ng/g
a) 760 ug/g
creatinine
c) 1200 ppb
d) 150 ppb
e) Not given
29.65 ng/»l
GENERAL IHFOBBATICN
5 and 95 perceotiles 7.00 and 32. US
ng/g. Median 19.00 ng/g. Autopsy
data.
Northern Bavaria
GERBANY; AOTOPSIES; ADIPOSE TISSOB;
BLOOD: BEAIN; KIDNEYS; LIVER; SPLEEN;
OBIHE; PENTACHLOROPHENOL
_
a) Occupational exposure
b) Reduced occupational exposure
d) Saie as b)
e) Controls
No correlation vith exposure tine or
age
PCP factory workers
ORINE; HEASOBEBENT BETHODS; CHLORINE
OBGUIIC COKPOOSDS; PBH1ACHLOEOPHMOL;
PESTICIDES; PESTICIDE EESIDDES
Detection lilit 1 ng/nl
GERHAHY; AOTOPSIES; ADIPOSE TISSUE;
BLOOD; BBAIN; KIDNEYS; LIVER; SPLEEN;
OEISE; PBHTACRLOBOPHEHOL
REFERENCE
Srill, H.-S.
Schellaanc, B.
Schaller, It.-H.
GossXer, K.
1931
Zentralblatt fuer
Bakteriologie,
Para si tenkunde ,
In f e kt ionskra nkheiten
and Hygiene, Abteilung
1. Originate , Peite B
174:77-90
Sigueira, B.E.P. B.
Fernicola, N.J.G.G.
Bulletin of
Environmental
ContaHination and
Toxicology 27:380-385
Griaa, H.-G.
Schaller, K.-H.
1981
Zentralblatt fuer
Bakteriologie,
Parasitenkunde,
Infektionskrankheiten
und Hygiene, Abteilung
1. Originale, fieihe B
174:77-90
NJ
O
Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
3380-34-5
C12-B7-C13-02
B» 289.5. BP 55-57 C
TISSUE
6650
Skin
EXPOSURE BOOTE
Demi
.
iNiLTTICAL
METHOD
Radio»etry
NOHBEB
OP CASES
1 per
tee at lent
EANGE
_
a) Not applicable
b) Not applicable
c) Hot applicable
d) Mot applicable
e) Hot applicable
f) Mot applicable
g) Mot applicable
MEAN
a) 0. 13 1 uq/sq ca
b) .79 ug/sq ca
c) "•. 106 ug/sq c»
d) .-. 114 ug/sg en
e) 0. 126 ug/sg ca
f) 0.241 ug/sq ca
g) < 0.01 ug/sg CB
GENERAL INFORMATION
a) 10 ain after wash with
conventional soap
b) 10 min after wash with
equilibrated soap
c) 10 Bin after wash vith n en- soap
detergent
d) 10 Bin after 6 washes with
conventional soap
e) 10 Bin after 6 washes with
equilibrated soap
f) 10 ain after 6 washes with
n en- soap detergent
g) 48 h after wash, all samples a)
through f)
Washed for 2 nin vith 0.25 mi of an
[3H]-DP300 fresh or equilibrated 1 wk
with shaking for 10 ain twice daily
Total epiderais plus derais
GE8HICIDE; SKIM; HATS
HEFERENCE
Black, J.G.
Howes, D.
Rutherford, T.
1975
Toxicology 3: 33-d7
-------
Phosphoric acid, 2,2-dichlorovinyl dimethyl ester (8 CI)
Phosphoric acid, 2,2-dichloroethenyl di.ethyl ester (9 CI)
62-73-7
C4-H7-C12-04-P
fin 220.98. BP 120 C at lit •• Kg
6651
Brine
EIFOSOEB ROUTE
ANALYTICAL
BF.THOD
HOB BEE
or CASES
17
RABGE
3.1-789.1 ug
BEAN
176.1 »or- 225.9 ug
GENERAL IHFORIIATION
vaponlte netabolite (0,0,dinethyl,
o-a«yl phosphate). Bean 8 hr outputs
for preshift, shift and postshift
periods. Hean air exposure 4.1-131.0
ug/cu n. workers also exposed to
Diazinon (0.8-41.0 ug/cu n) which
yields sane urinary netabolite
Pest control operators, Texas
TEXAS; URINE: INDUSTRIAL RIGIENE;
ORGANOPBOSPBATES; OCCUPATIONAL
BAZARDS; PESTICIDE RESIDUES
Hayes, ».L.
Rise, S.A.
Heir. F.H.
1980
Anerican Industrial
Hygiene Association
Journal 41:568-575
Phosphorodithioic acid, s,s'-»eth)rlene 0,0,0',0'-tetr«ethyl ester
563-12-2
C9-B22-04-P2-S4
Bit 384.48, IP -12 to -13 C
TISSUE
6652
Urine
EXPOSURE ROUTE
Inhalation
Dernal
ANALYTICAL
BETRCD
GC
NUBBEB
OF CASES
17
RANGE
a) 137. 1-470.4 ppb
b) 71.5-282.0 ppb
c) 119.8-642.1 ppb
d) 89.6-541.1 ppb
BEAN
a) 266.3 »or- 111.3
ppb
b) 132.8 *or- 75.9
ppb
c) 349.8 «or- 167.6
Ppb
d) 183.2 tor- 139.5
ppb
GEHEBAL IK FOR BAT IOK
a) Diethyl thiophosphate. 8 workers
who niiefl ethion ana filled spray
tanks
b) Diethyl thiophosphate. 9 workers
who operated tractors pulling ethion
air blast sprayers
c) Diethyl dithiophosphate. Saie as
a)
d) Diethyl dithiophosphate. Sane as
b)
Range of neans
Estinates given for levels of dernal
and respiratory exposure
Citrus grove workers, Florida
FLORIDA; URINE; PESTICIDES;
AGRICULTURE; CROP DUSTING;
OCCUPATIONAL HAZARDS; ORCBARDS;
PESTICIDE RESIDUES
Kojeck, G.A.
Bigg, H.N.
Stanper, J. B.
Bradway, D.E.
1981
Archives of
Environmental
Contamination and
Toxicology 10:725-735
-------
Phosphorcthioic add, 0,0-diethyl o-(p-aitrophenyl) ester (8 CD
Phosphorothioic add, 0,0-diethvl 0- (4-nitcophenyl) ester (9 CI)
56-38-2
C10-H14-I-05-P-S
81 291.27, SP 6 C, BF 375 C at 760 » Sg, 157-162 C at 0.6 » flg
TISSUE
6653
orine
B IPOS ORE BOUTS
AJUiyTICAL
HETHOD
GC
IDHBB1
OF C1SES
23-40
B1SGE
a) 0.10-0.19 pp«
b) lot detectable-0.19
PP«
c) lot detectable-0.28
pp»
d) 0.10-0.22 pp.
e) Hot detectable-0.15
pp.
f) Hot detectable
h) 0.10-0.13 ppi
pp.
•j) <0. 10-0. 30 pi
1} Mat detectable
•) Sot detectable
a) <0. 10-0. 59 ppa
p) Hot detectable
q) Hat detectable
«EJJ
a) Hot give
b) Mot give
c) Hot give
d) Hot give
e) Hot give
f) Hot give
g) Hot give
b) Hot give
i) Hot give
k) Hot give
•) Hot give
a) Hot give
p) Hot given
q) Hot given
GBHBUAL INFORHATICH
a) 0,0-DiBethylphosphoric acid (DHP) ,
farmworkers, baseline
b) 0,0-Diethylphosphorothioic acid
(DETP) , f ar« workers, baseline
c) 0,0-Diaethylphosphorothioic acid
(DHTP), farmworkers, baseline
d) DHP, f ariuockerSf reentry
e) DETP, facMHorkecs, reentry
f) DHTP, farKvorkers, reentry
h) DBTF, farmworkers, post reentry
^) DHP, volunteers baseline
k) DHP, volunteers, baseline controls
•) DHTP, volunteers, baseline
n) DHP, volunteers, reentry
p) DETP, volunteers, reentry
g) DflTP, volunteers, reentry
Baseline (1*3 mo before), reentry,
and postreentry (2-3 HO after) levels
(1 trk before) and reentry levels for
student volunteers working in groves
treated 30 days earlier with
parathion (H lb/100 gal water/acre or
assigned to untreated plots. Daily
•edian values also given '
older, and 19-28 yr old college
students, CA
Baseline (nonexposure)
acetylcholinesterase (AChE) and
plasma cholinesterase (PChE)
activities were significantly higher
volunteers PChE declined but AChE and
residue levels changed little after
exposure
CillFORHIA; ADDLTS; OEIHE;
OPGiSOPHOSPBATES; PESTICIDES; CHOP
DOSTIHG; FAB MS; HETABOtlTES;
OCCUPATIOHAi HAZARDS
Kraas, J.F.
Hull, B.
Kurtz, t.
Hinterlln, ».
Frantl, C.E.
Borbani, H.
Kilgore, 8.
1981
Journal of Toxicology
and Environmental
Health 8:169-18tt
Phosphorothioio acid, 0,0-diethjl 0-(3,5,6-trichloro-2-pyridrl) ester (8 CI)
Phosphorcthioic acid, 0,0-diethyl o-(3,5,6-trichloro-2-pyridinrl) ester (9 CI|
2921-88-2
C9-B11-C13-B-03-P-S
H« 350.57, HP ai-»2 C
TISSDE
6651
Urine
El POSH BE BOOIE
IHILITICAL
BETBOD
6C
IDHBEB
OF CASES
16
BINGE
a) 4.8-344.1 ug
b) 1.0-34.9 ug
HEiN
a) 48.3 tor- 58. 6 ug
b) 8.3 +or- 9.0 ug
GEHEBAL INFOFHkTION
a) 0,0-diethyl, 0-aiyl phosphate
b) 0,0-diethyl, 0-a.yl
phosphorothiooate
Average 8 hr outputs for preshift,
shift and postshift periods. Hean
air exposure 0.4-27.6 (Bean 7.54)
ug/cu B
TEXAS; 0RIHZ; IHDOSTRIAL HYGIEHE;
ORGABOPHOSPBATE5; OCCDPATIOHAl
HAZABOS: PESTICIDE BESIODES
BEFEBESCE
Hayes, A.I.
vise, B.A.
«eir, F.«.
1980
American Industrial
Hygiene Association
Journal 41:568-575
-------
Fhosphorothioic arid, o,o-aiethyl, O-(2-isopropyl-6-«ethyl-4-pyri»idinyl ester (8 CI)
Phosphorothioic acid, o,0-diethyl o-(6-»ethyl-2-(1-»ethylethyl)-»-pvri»ioinyl) ester 19 CI)
333-41-5
C12-H21-N2-03-P-S
HW 301.36, IIP aecoip above 120 C, BP 83-8H C at 0.002 n Bg, TF 4. 1110 (E-4) at 20 C, l.1X10(E-3) at 40 C
TISSUE
6655
Urine
EXPOS ORE ROUTE
-
ANALYTICAL
BETHOD
6C
NOSBER
OF CASES
17
RANGE
a) 31-789. 1 ug
b) 3.3-7.9 ug
HE1H
a) 176.1 «or- 225.9
ag
b) 5.6 tig
GENERAL INFOBBATIOH
a) 0,0-diiethyl, O-aiyl phosphate
b) 0,0-diiethyl, 0-a«yl
phosphorot h iona te
shift and postshift periods. Bean
air exposure 0.8-41.0 (lean 6.29)
Taponite (4.1-131.0 ug/cu I) vhich
produces •etabolite (a)
TEXAS; URINE: INDUSTRIAL HTGIENE;
ORGAHOFHOSPHATES; OCCUPATIONAL
HAZABDS; PESTICIDE EESIDDES
BEFE PENCE
Hayes, A.I.
wise, B.A.
Weir, F.H.
Aierican Industrial
Hygiene Association
Phosphorus
7723-14-0
F
lt» 30.97376, DP 44.1 C, EP 280 C, TP 10 mm Hg at 127 C
TISSUE
6656
Rdrenal
gland
6657
Aorta
EXPOSDRE ROOTE
AHAL1TICAL
HETHOD
ES
ES
HOUSE!
OF CASES
7
..
B1HGE
Hot given
Hot given
HEAH
3500 «or- 1400 pp»
dry «t
»t
GENERAL IHFOS HATIOH
HorBal tissue
Autopsies
Japan
TOHGOE; ZIRCOHIOH; ELEHEHTS; JAPAH;
ADDLTS; AUTOPSIES; IDEENiL GLARDS;
AOBTA; BONES; HEART; INTESTINES;
KIDHEIS; LITER; LDNGS; LTHPH »OD1S ;
SPIEHI; PXBC8EAS; 3TOBACH; THTBOID
GtAHDS; TRACBEA; ALOHIHDB; BARIOH;
CADBIOfl; CALCIDH; CHROHIOH; COBALT;
COPPER; 1801; LEAD; BAGNESIOB;
RAHGARESE; 9ETALS; HOLIBDE9DH;
NICKEL; PEOSPHOROS; POTASS 1011;
SILICON; SILTER; SODIDB; ST80NTIUH;
TIN; TITANIOB; TANADIDH; ZINC;
BIOACCBHOLATION ; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
Autopsies
Japan
TONGUE; ZIKCONIOH; ELEHEHTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; EONES: BEAST; INTESTINES;
KIDNETS; LITER; LONGS; LTHPB NODES;
SPLEEN; PANCREAS; STOHACH; THTEOID
GLANDS; TRACBEA; ALDHIIU8; BARIOB;
CADHIUH; CALCIDB; CHBOBIDB; COBALT;
COPPER; IRON: LEAD; BAGHESIOB;
HANGAHESE; BETALS; HOLTBDENUH;
NICKEL; PHOSPHORUS; POTASS IOB;
SILICON; SILTER; SODIDB: SIRONTIUH;
TIN; TITAN'IUH; TANADIUH; ZINC;
BIOACCDBDLATIOK; REALTB HAZARDS;
OCCUPATIONAL HAZARDS
..
REFERENCE
Teraoka, H.
1981
Archives of
36(4) : 155-165
1981
Archives of
Environmental Health
36(4): 155-165
(NEXT PAG£)
S3
O
-------
Phosphorus
7723-14-0
P
Atw 30.97376, tip 44.1 C, BF 280 C, TP 10 mm Eg at 127 C
(CONTINUED)
TISSOE
6658
Blood,
plasaa
6659
Blood,
seruB
6660
Bone
EXPOS ORE FOU1E
Inqestion
AHALYTICAL
SETBOO
..
AAS
Photometry
IS
SOflBEB
OF CASES
a) 20
Ml 20
2
5
BINGE
a) Hot given
b) Sot given
a) 3.5-4. 1 mg/100 ml
b) 3.8-4.0 >9/100 .1
c) 3.0-3.5 mg/100 ml
d) 3.1-3.5 mg/100 »1
Hot given
HEAH
a) 3.08 +or- 0.68
umol/1
b) 2.92 tor- 0.6
u no 1/1
a) Not given
b) Hot given
c) Hot given
d) Hot given
46000 «or- 14000 ppm
dry wt
GEHF.BAL HFORHATION
a) Limited care dialysis patients
b) Hoie dialysis patients
Clinically stable patients on
intermittent dialysis >9 tenths
HEHODISLTSIS; KI1HET DISEASES;
CALCION; BET»LS; PHOSPHOBOS; BLOOD;
BLOOD PLtSHt; XLDSI »!]!•.
..
a) Subject 1, intake 1288 ig/24 hr.
low fiber diet
b) Subject 1, intake 1740 ig/24 hr.
high fiber diet
c) Subject 2, intake 1400 ig/24 hr.
d) Subject 2, intake 1940 ig/24 he.
high fiber diet
Total dietary intake
for 20 days followed by 20 days on
high fiber, moderate phytate local
bread
35 and 24 yr old, wt 56.0 6 60.3 kg.
Iran
IE1H; iDULTS; HOTEITIOH11L
DIYICISHCIES; BLOOD PLaSfli; BLOOD
SEDOK; tJBINE; CA1CIOH; IUGNESIOB;
tBOSPHOEDS; ZIHC; DJSTS; FIBESS;
FOODS; BETiLS
Norial tissue
Autopsies
Japan
TCSGUE: ZIRCONIOB; ELEnEHTS; JAPAN;
J DOLTS; AOTOPSIES; ADEE8AL GLANDS;
AOBTA: BONES; HEJBT; INTESTINES;
KIDHETS; LIVED; LONGS; LtBPfl HODES ;
SPLEEH; PANCBEAS; STOSACH; THYBOID
GLAHDS; TEJCHEA; ALOBISOB; BASIDfl;
CADHIOH; CAlCtOM; CHBOBinB; COBALT;
COPPEE; IBOH; LEAD; BAGHESIOB;
HAHGAHESE; HETALS; HOLTBDEBOr,;
HICKEL: PHOSPHOBOS: POMSSIOfl;
SILICON; SILVEB; SODIDI1; SIBOHTIDS;
TIN; TITANIITB; VANADIDfl; ZINC;
BIOICCTHOLATIOH; HEALTH HAZARDS:
0 CCU PIT ION 11 BAZABDS
BEFEBENCE 1
Znikley, H.
Bertram, H.P.
Graefe, a.
Langer, K.
1980
Proceedings, University
of Hissonri Annual
Conference on Trace
Substances in
Environmental Health
14:299-303
Beinhold, J.G.
Faradji, B.
Abadi. P.
Ismail-Beigi, F.
1976
106:493-503
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
(HEIT PAGE)
NP
O
-------
Phosphorus
7723-11-0
P
At« 30.97376, HP 11.1 C, BP 280 C. »P 10 » Hg at 127 C
(CONTINUED)
TISSUE
6661
Heart
6662
Intestine
6663
Kidnev
EXPOSURE B001B
AB&ITTICiL
NET HOD
ES
ES
ES
HOT BEE
OF OSES
a) 8
b) 2
c) 3
d) 1
e) 1
10
a) 8
b| 2
c) 3
d) 1
e) 1
BASSE
a) not given
b) 1200-3000 pp»
c) 1200-1900 ppn
d) Hot applicable
e) Hot applicable
Dry »t
Mot given
a) Not given
b) 1500-3200 pp>
c) 1300-5000 pp»
d) lot applicable
e) Dot applicable
Dri lit
BEAM
a) 3100 tor- 1700 pp«
b) 2100 pp«
c) 2633 pp«
d) 2000 ppl
e) 2100 ppa
Dry wt
2100 »or- 930 pp» dry
wt
a) 3800 *or- 1800 ppl
b) 23SO ppl
c) 2867 pp»
aj 3100 pp»
e) 2800 pp«
Dry vt
GENEBAL IBFORHATIOI
a) Norial healthy len
b) chromium plating workers
c) chroiate refining workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
TCBGOE; ZIBCONIOH; ETEBESTS; JAP AS;
ADULTS; AUTOPSIES; ADBEMAL GLANDS;
AOGTA; BONES; HEABT ; IBTESTIHES;
KIDIEIS; LIVER: LOVES; LIBPH (ODES:
SPLEEH; PANCREAS; STOHACH; THTROID
GLANDS; IE AC HE A; ALOfllHOfl; BARIOB;
CADBIOS; CALCIOS; CHBOBIBH: COB»LT;
CCPPEB; I BOH; LEAD; flAGNES 101!;
BAHGAHESE; flETALS; BOLIBDEIDB;
•ICKEL; PHOSPHORUS: POTASSIDB;
SILICON; SILVER; 30DIUB; STROITlnfl;
TIH; TITA1IIOB: TABADinH; ZUCj
BIOACCDBOLATIOH; HEALTH HAZABDS;
OCCOPATION1L HAZARDS
BotBal tissue
Autopsies
Japan
TOKGUE; ZIHCOSIOB; ELEBEBTS; JAPAN;
ADULTS; JHTOFSIES; ADSEKAL GLJKDS;
AORTA; BOIES; HEART; IHTESTIUBS;
KIDRETS; LITER; LDIGS; LTHPH BODES;
SPLEEN; PAICREAS; STOBACH; THTROID
GLARDS; TBACREA; ALOBIITOB; BAEIOB;
CADHIDH; CALCIOB; CHfiOBIOB; COBALT;
COPPEB; IBO»; LEAD; BAGBESIOB;
BANGANESE; BETAL5; BOLIBDEJOB;
» ICKEL: PHOSPHORUS; POTASSID8;
SILICON; SILVER; SO DIOR; STBOBTIOK;
Til; TITAIHOH; VAHADIDH; ZIIC;
BIOACCaNULATION; HEALTH HAZARDS;
OCCllPATIOBAL HiZABDS
a) »or«al healthy >en
b) chroiloM plating vorfcers
c) Chroiate refining workers
d) Airplane painter
e) stone «ason
Autopsies
Japan
TCBGOE; ZIBCOIiaa; ELEBEHTS; JJPA»;
ACDLTS; AUTOPSIES; ADBEKAL GLAHDS;
AOETA; BONES; HEART; UTESTIHBS;
KIDIETS; LIVER; LDNGS; LTHPH BODES;
SPLBEB; PAKCSEAS; STOHACH; THtBOID
GLAIDS; TBACHEA; ALUBIITOB; BARIOB;
CADBIUS: CALCIDB; CHBOBIOB; COBALT;
COPPER; IRO>; LEAD; BJGBESIOB;
HAX3AKESC; FlETALS; HOLTBDEStJB;
NICKEL; EHOSPHOB0S; POTASSIOfl;
SILICON: SILVER; SODIOH; STBOHTIOB;
TIB; TITABIDH; VABADIDH; ZIIC;
BIOACCOBDLATIOS; HEALTH HAZARDS;
OCCDPATIOHAL HAZARDS
REFERENCE
Tetaoka, H.
1981
Archives of
Environmental Health
36(»): 155-165
Tecaoka, H.
1981
Archives of
Environiental Realth
36(«): 155-165
Teraoka , H*
1981
Archives of
Environmental Health
36(») : 155-165
(NBIT PAGE)
K)
O
00
-------
Phosphorus
1723-14-0
F
AtB 30.97376, HP 44.1 C, BP 280 C. IS 10 •• Bg at 127 C
(COHTIBDED)
TISSOE
666H
Liver
6665
lung
6666
lyiph
node
EIPOSOBE POBTE
.
ANALYTICAL
BETBOD
ES
ES
ES
HOBBEB
OF OSES
a) 9
b) 2
cl 3
a> i
e) 1
a) 12
b) 2
C) 3
d) 1
e| 1
a) 3
b) 1
0 3
d) 1
e) 1
BABGE
a) Hot given
b) 3200-4200 PPB
c) 2300-5100 ppm
d) Hot applicable
e) Hot applicable
Dry »t
a) Hot given
b) 1700-3500 ppm
c) 1700-4300 ppm
d) Hot applicable
e) Hot applicable
Dry vt
„
a) Hot given
b) Hot applicable
c) 2600-3900 pp»
d) lot applicable
e) Hot applicable
Dry »t
HE 4S
a) 5000 toe- 2500 pp*
b) 2700 ppa
c) 4233 ppa
d) 3900 ppl
e) 1900 ppB
Dry wt
a) 4800 toe- 2300 ppi
bi 2600 ppfi
c) 3033 ppa
d) 2800 ppm
e) 3600 ppB
Dry »t
a) 6100 »ot- 3000 p,>B
b) 4600 ppm
c) 3433 pp»
d) 4200 ppm
&i 10,000 ppa
Dry vt
GENEBiL IIFORflATIOH
a) loraal healthy Ben
b) chroniiiB plating uorkars
c) chromate refining workeES
d) Airplane painter
e) S tone Bason
Autopsies
Japan
TCHGOE; ZIECOHIOH; ELEHEHTS; JiPlH;
kDOT. 15; kOTOPSIES; ADBSHU GLMDS;
10BTA; BONES; HE1BT: IHTESTIHES;
KIDHEIS; LITEB; LOHG5; LIBPB IODES;
SPIEEIT; P1HCBESS; SIOSICHJ THTFOIB
GLHOS; TE1CHHM HOHIiail; BiBIOH;
CADHIOH; C1LCIOB; CH80BIDH: COBALT;
COPPEB; IBOH; LEAD; HAGHESIDB;
8AHGAHESE; SETALS; BOLTBDZHOH;
8ICKEL: CBOSCHORHS; POTASSIOH;
SILICOH; SILVEB; SODIDH; SIBOHTIOP1;
Til; TITIBIOB; TAIADIOH; ZIHC;
BIOACCUMULATIOH; HEALTH HtZASDS;
OCCDPATIOHAt HAZABDS
a) Horaal healthy Men
b) chEomitu plating norkers
c) chroiate refining nortecs
d) Airplane painter
e) Stone Mason
Autopsies
Japan
TOBGUE-, H8COSIOB; ELEHIBIS; J»Pl»;
ADULTS; AUTOPSIES; ADREBAL GLABDS;
AORTA; BOHES; HEART; IHTBSTIBES;
KIDHEIS; LIVER; LOBGS; LIHPB HODES;
SPLEBH; PKBCBEAS; STOB1CB-, THIBOIB
GLABDS; TBACBEA; ALOHIHOII; B1BIUH;
CADHIOB; CAICIOB; CRBOBIOB; COBALT;
COPPEB; IROH: LEAD; BAGHESIDH;
BAHGAHESE-. 8ETALS; HOLIBDEBUB;
NICKEL; PBOSPHORDS; POTASSIOB;
SILICOH: SILVER; SODIOB; STBOBTIOB;
TIB; TITAHIOn; VAHADIDB; ZIBC;
BIOACCUflVLATIOB; REALTB HlIiBDS;
OCCUPATIONAL BAZARDS
a) Bornal men
b) chroBiuB plating vorker
c) chronate refining workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
TCSGtlE; ZIRCONIOB; ELEHEHTS; JAPAH;
ADULTS; AUTOPSIES; ADBEHAL GLAHDS;
AOBTA; EOSES; BEABT; INTESTINES;
KIDBEIS; LI?EB; LOHGS; LTBPH »ODES;
SPLEEH; PANCREAS; STOBACB; TBIBOID
GLABDS; TBACBEA; ALDgilOB; BABIOB;
CADBIOB; CALCIUB; CHBOBIUB; COBALT;
COPPER; IBOI; LEAD; BAGNESHJP;
BABGAHESE; 8ETALS; BOLTBDEBDH;
NICKEL; PBOSPBOBDS; POTASSIOB;
SILICOB; SILVER; SODIDB; STBOBTIOB:
TIB; TITABIOR; VAB4DIOH; ZIBC;
BIOACCOHDLATIOB; BE1LTB HAZABDS;
| OCCUPATIONAL BAZ1RDS
(BEIT PAGE)
Teraoka, B.
1-981
Arcaives of
Environnental Health
36(4):155-165
Teraoka, H.
1981
Archives of
EnvironBental Health
36(4) :155-165
S3
o
Teraoka, H.
1981
Archives of
Environmental Health
36(«):155-165
-------
Phosphorus
1723-11-0
p
At« 30.97376, HP 44.1 c, BP 280 C. VP 10 « Bg at 127 C
(CONTINUED)
TISSOE
6667
Pancreas
6668
Spleen
6669
StOBach
EXPOSURE ROOTS
A Hitmen
NETHOD
ES
-
ES
ES
NDflBER
OF CASES
5
a) 9
b| 2
ol 3
4) 1
e) 1
to
BUGS
Not given
a) Not given
b) 3600-5000 pp.
c) 1800-6000 pp.
d) Hot applicable
e) Hot applicable
Dry »t
Not given
BEAN
6400 +or- 1900 ppB
dry «t
a) 4900 *or- 2600 ppn
b) 4300 pp.
c) 4433 pp.
d) 5200 ppa
e) 5200 ppm
Dry wt
2100 *oc- 930 ppm dry
wt
GENERAL IHFORBATION
Mortal tissue
Autopsies
Japan
TONGUE; ZIBCONIOfl; ELEMENTS; JAPAN:
ADOLTS; AUTOPSIES; ADRENAL SLANDS;
AOKTA; BONES: BEABT; IHTESTINES;
KIDNETS; LI1TEE; tOKGS; LTHPH NODES;
SPLEEN; PANCREAS; STOBACH; TBYEOID
CLAUDS; TEACHEA; ALUBINUH; BAP.IOB;
CAE8IOB; CALCIOfl; CHROBIOB ; COBALT;
COPPEH; IP.ON; LEAD; BAGNESIHH:
BANGANESE; BETALS; BOLTEDENOB;
NICKEL; PBOSPBOBOS; POTASSIOS;
SILICOB; SI1VEH; SODIOH; SWONTIOB:
TIN; TITANIOB; 7ANADIOB; ZINC;
BIOiCOimiLATION; HEALTH HAZARDS;
OCCDPATIONAL HAZARDS
a) Nornal healthy nen
b) ChroaiuB plating workers
c) ChrOBate refining workers
i] Airplane painter
e) Stone vason
Autopsies
Japan
TONGUE; ZIRCONIHB; ELEBENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL SLANDS;
AORTA; BONES; HEART; INTESTINES;
KIDNEYS; LITER; IOSGS; LTHPH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLANDS; TRACHEA; ALOBINDB; BARIDB;
CADHIUB; CALCIOS; CHROBIOB; COBALT;
CCPPER; IRON; LEAD; BAGNESIOH;
BANGANESE; DETALS; BOLYBDENUB;
NICKEL; PHOSPHOHDS; POTASSIOH;
SILICON; SILVER; SODIOH; STBONTIOH;
TIN; TITANIOH; VANADIOB; ZINC;
BIOiCCOBOLAZION; HEALTH HAZARDS;
OCCVPATIONAL HAZARDS
Noraal tissue
Autopsies
Japan
TONGOE; ZIRCONIOB; ELEHENTS; JAPAN;
ADULTS; AOTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEART; INTESTINES;
KIDNEYS; LIVER; LOHGS; LYBPH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLANDS; TRACHEA; ALOBINOB; BARIUH;
CIDHIVH; CALCIOB; CBROBIOB; COBALT;
COPPER; IRON; LEAD; HAGNESIOH;
HANGANESI; BETALS; BOLYBDENOtl;
NICKEL; PHOSPBORDS; POTASSIOB;
SILICON; SILVER; SODIOB; STRONTIOH;
TIN; TITANIOB; TASADIOB; ZINC;
BIOACCO BOLATION; HEALTH HAZARDS;
OCCOPATIONAL HAZARDS
Teraoka. B.
1981
Archives of
Bnvironaental
36(4): 155-165
Teraoka, H.
1981
Archives of
EnvironBental Health
36(1):155-165
I-1
O
Teraoka, H.
1981
Archives of
EnvironBental Health
36(4) : 155-165
(NEXT PAGE)
-------
Phosphorus
1723- 1
-------
Phosphorus
1723-11-0
I
At» 30.97376, IIP 14.1 C. BP 260 C, IF 10 •• Hg at 127 C
(CONTINUED)
6673
Urine
EXPOSURE BODTE
Ingestion
ANALYTICAL
BBTBOD
Photometry
. -
NDHBEB
OF OSES
2
BANGS
a) Hot given
b) Hot given
c) Hot given
d) Hot given
BEAN
a) 764 tor- 51 ig/100
•1
b) 654 tor- 69 « g/1 00
.1
c) 887 *or- 21 ig/100
d) 12*0 tor- 75
•g/100 .1
GENERAL INFOEBATION
a) Sub-fee t 1, intake 1288 ig/24 hr.
lav fiber diet
t) Subject 1, intake 1740 ig/24 hr.
high fiber diet
c) Subject 2, intake 1400 ig/24 hr.
d) Subject 2, intake 1940 ig/24 hr.
high fiber diet
for 20 days followed bj 20 days on
high fiber, Moderate phytate local
bread
35 and 24 jr old, «t 56.0 B 60.3 kg.
Iran
IBA»; ADULTS; NUTRITIONAL
DEFICIENCIES; BLOOD PLASBA; BtOOD
SEBOH: URINE; CALCIUB; BAGHESIOB;
EHOSPHOBUS; ZINC; DIETS; FIBEBS ;
FOODS; BETJLS
BEFEfiEHCE
Beinhold, J.s.
Paradji, B.
Ibadi, P.
Isiail-Beigi, F.
1976
106:493-503
PlDtoniui
7440-07-5
Etf
AtV 242, 244, BP 639.5 C (also reported as 641 C), BP 3232 C
(MBIT PAGE)
TISSDE
6674
Body
6675
Bone
EIPOSUBE BODTE
-
ANALYTICAL
HETBOD
SOB BEE
OF CASES
BiKGE
BEAN
SEIEBAL HFOBBJTIOK
ivpact of pu and consideration of
protection standards
GONADS; AUTOPSIES; CASE HISTOBIES;
BODY; BOIES: KIDNEIS; LIVEB; LONGS;
LinpH NODES; SKIN; PLOTOIION; AIB
POLLUTION; INDOSTEIAL ACCIDENTS;
OCCUPATIONAL BAZABDS; BADIATION
DOSES; EJDIONOCLIDBS
Bevieu. Evaluatioo of environ«ental
iipact of pn and consideration of
protection standards
GONADS; AUTOPSIES; CASE HISTOBIBS;
BODY; BONES: KIDNEYS; LIVES; LONGS;
LYBPR NODES; SKIN; PLOT01IOB; AIR
POLLUTION; INDDSTBIAL ACCIDENTS;
OCCOPATI01AL HAZABDS; BADIATIOI
DOSES; BADIONDCLIDES
BEFEBENCE
Yoder, U.K., Ir.
>renn, B.E.
Bennett, B.G.
Bair, W.J.
Burr, 8. »., Jr.
Bichmond, C.R.
Thompson, B.C.
Stannard, J.N.
1974
EPA Testimony, December
10-11. 1974,
Hashing ton, DC,
RASH-1359, 339 pp.
Liveman, J.L.
Yoder, B.E., Jr.
Vrenn, B.E.
Bennett, B.G.
Bair. K.J.
Burr, B.B., Jr.
Bich.ond, C.B.
Thoapson, B.C.
Stannard, J.H.
1974
EPA Testinonr, December
10-11, 1974,
lashington. DC,
WASB-1359, 339 pp.
-------
Flutoniui
7440-07-5
Fu
its 212, 2111, HP 639.5 c (also reported as 641 C) , BP 3232 c
(CORTIBOED)
TISSUE
6676
Gooads
6677
Kidney
6678
lirer
6679
Lung
EXPOS0BE ROUTE
AHALTTICiL
HETHOD
HU9BEB
Of CASES
BARGE
(BEIT
BEA»
PAGE)
GEIEBAL IBFORHSTIOB
iipact of Pu and consideration of
protection standards
GORADS; ADTOPSIES; CASE HISTORIES;
BODT; BORES; KIDHETS; 1IVEB; LOBGS;
ITRPH NODES; SKIR: PLOTORlna; >IB
FOILOTIOR; IRDOSTBIAL ACCIDENTS;
OCCUPATIONAL HAZABDS; B&DI&TIOH
COSES; BADIOROCLIDES
iipact of Pu and consideration of
protection standards
GONADS; iOTOPSIES; CASE HISTORIES;
BODT; BOHES; KID BETS; LIVES; LffNGS;
IIBPH NODES; SKIH; PLOTOMIOH; AIE
POILOTION; INDOSTRIiL ACCIDENTS;
OCCUPATIONAL HAZABDS; BADIATIOH
COSES; RIDIOSOCLIDES
_ - - - -
BeTiev. Evaluation of enTironiental
iipact of Pu and consideration of
protection standards
GOIADS; AOTOPSIES; CASE HISTOBIES;
BODT; BONES; KIDRETS; UTEB; LOIGS;
ITHPB NODES; SKIB; PLOTOSIOn: AID
P011DTIOB; IBDUSTEIAL ACCIDEBTS;
OCCOPATIOBAL BAZABDS; BADIATIOK
CCSES; EHDIOBOC1IDES
iapact of Pu and consideration of
protection standards
GOftADS; AUTOPSIES; CASE HISTOBIES;
BODT; BORES; KIDRETS: LIVER; LDRGS;
LTHPH BODES; SKIB; PLDTOHIDH; AIR
POLLUTION; IRDOSTRIAL ACCIDENTS;
OCCOPATIOBAl BAZABDS; BADIATIOB
DOSES; RADIONOCIIDES
BEFEBEBCE |
1
loder, R.E. , Jr.
Hrenn, n.E.
Bennett* B.G.
Bair, K.J.
Burr, ».»., Jr.
Richmond, c.R.
Tboipson, B.C.
Stannard, j.n.
1974
EPA Testiaonr, Deceaber
10-11, 197U,
Washington, DC,
»»SH-1359, 339 pp.
Toder, R.E. , Jr.
Krenn. (I.E.
Bennett, B.G.
Bair. 8.J.
Burr, ».»., Jr.
Richaond, c.B.
Thompson, B.C.
Stannard, J.B.
197K
EPA Testimony, Deceaber
10-11, 197»,
Washington, DC,
WASH-1359, 339 pp.
Livernan, J.L.
rader, E.E., Jr.
wrenn, I.E.
Bennett, B.G.
Bair. V.J.
Borr, U.S., Jr.
Bichiond, C.B.
Thompson, B.C.
Stannard, J.B.
1974
10-11, 1974,
(Tashington, DC,
HiSH-1359, 339 pp.
Toder, B.E., Jr.
wrenn, a.E.
Bennett, B.G.
Bair, W.J.
Burr, ».«., Jr.
Bichiond, C.R.
Thompson, B.C.
Stannard, J.B.
1974
EPA Testinon?, Decenber
10-11, 1974.
Washington, DC,
WASH-1359, 339 PP-
ro
h-1
U)
-------
Plutonium
7HUO-07-5
Fu
At» 212, 2
GENERAL INFORMATION
a) Faners
b) Chemical vorkers
16-59 yr old faciers with knovn PBB
exposure and disabling health
problems, aod 23-62 yr old chemical
vorkers in PBB manufacture, aichigan.
Bepatomegaly and skin rashes in
farmers. Binor elevations of serum
uric acid, iron, cholesterol and
triglyceridos
MICHIGAN; BLOOD SEBOH; BBOHINE
ORGANIC C08POUNDS; BIPHENTL
COBPODNDS; OCCDPaTIONAL HAZABDS:
POPnlATION BXPOSORE; ADIPOSE TISSDE;
F1BHS; HEALTH HAZARDS; POLYBHORIR1TED
BIPBMILS; FOOD COSHHIHiTION
Stross, J-K.
Smokier, I.A.
Isbister, J.
Oilcox. K.R.
1981
Toxicology and Applied
Pharmacology 58:105-150
-------
Polybroiinated biphenyls («o postings In CHE1LME).
TISSDE
(COBTI80EDI
EXPOSURE ROOTE
ANALYTICAL
BET BOD
NOBBSR
or CASES
a) 23
b\ 28
c) 9
BiHGE
a) lot given
b) Mot given
c) Hot given
BEAN
-
a) 0.011 PP«
b) o.o»8 pp»
c) 0.002 pp«
GENERAL INFORBATION
a) Farmers
b) Chemical workers
c) Public Health staff( controls
16-59 yr old farm-rs with known PBB
eiposure and disabling health
problems, and 23-62 yr old chemical
workers in PBB manufacture, Hichigan.
farmers, ninor elevations of serum
aric acid, iron, cholesterol and
triglycerides
HICHIGAN; BLOOD SEROH; BBOniBE
OEGANIC COBPOOSDS; BIPHEilYL
COBPOOHDS; OCCOPATIOSJt HAZARDS ;
POPOLATIOB EKPOSOflE; ADIPOSE TISSOE;
FABHS; HEALTH HAZARDS; POITBEOH INATED
BIPHE8YLS; POOD COST HBIH1TION
EEPEEESCE I
1
stross, J.K.
s«okler, I. A.
Isbister. j.
»ilcoi, K.B.
1981
Toxicology and Applied
Phariacology 58:145-150
Eotassiua
74110-09-7
S
AtH 39.098, HP 63.2 C, BP 765.5 C, VP 100 >• Hg at 590 C
6684
Adrenal
gland
6685
Aorta
EXPOSOBE BOD1E
AHALITICAL
METHOD
ES
ES
HDBBEB
OP CASES
7
7
BJNGE
Hot given
Not given
._
4500 +or- 2400 ppm
dry »t
3700 +or- 600 ppa dry
lit
(BEIT PAGE)
GEBEEAL INFOBBATICN
Noraal tissue
Japan
TCDGOE; ZIRCOKIOH; ELEBE1ITS; JAPAN;
ACOLTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEART; INTESTINES;
KIDNEYS; LITER; LONGS; LYI1PH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLANDS; TRACHEA; At OBIHI9; BABIHH;
CAniSIDH; CALCIUH; CHSOHIOH; COBALT;
COPPER; IRON; LEAD; BAGNESIUH;
KANGANESE; BETALS; BOLYBDENOH;
NICKEL; PHOSPHORUS; POTASSIOB;
SILICON; SILVER; SODI09; STHONTIOB;
TIN; TITANIOB; VAHADIOfl; ZINC;
BIOICCOBOLATION; HEALTH HIZABDS;
OCCOPATIONAL HAZARDS
Norial tissue
Japan
TOHGOE; ZIRCONIOB; ELESENTS; JAPAN;
ADULTS: AUTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEART; INTESTINES;
KIDNEYS; LIVER; LONGS; LYHPH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLANDS; TRACHEA; ALOHINOB; BABIDB;
CIDDIOB; CALCIOB; CHROBIOB; COBALT;
COPPER; IRON; LEAD; HAGNESIOH;
(UHGANESE; BETALS; HOL YBDENtTH;
NICKEL: PHOSPHORDS; POTASSIOH;
SILICON; SILVER; SODIOfl; STRONTIBH;
TIN; TITANIOB; VANADIUB; ZINC;
BIOACCUBOLATION; HEALTH HAZARDS;
OCCOPATIONAL HAZARDS
Teraoka, H.
1981
Archives of
Environmental Health
36(»):155-165
Teraoka, fl.
1981
Archives of
Environmental Health
36(4): 155-165
-------
Pctassiui
7440-09-7
K
Its 39.096, IP 63.2 C, EP 765.5 C, VP 100 •• Hg at 590 C
(CONTINUED)
TISSUE
6686
Blood,
serua
6687
Bone
6688
Bale
1
1
BIPOSOBE EOUTE
Ingestion
ARALYTICAL
B ETROD
IS
RA
NOBBER
OF CASES
20
5
BAHGE
a) 3.0-1.4 lEq/1
b) 3.2-5.2 lEq/1
c) 3. 1-4.2 »Eq/l
d) 3.0-4.8 lEq/1
e) 3.1-4.5 .Eq/1
f) 2.9-4.0 .Eq/1
g) 3.2-4.0 .Eq/1
h) 3.1-4.3 «Eq/l
i) 3. 1-4.0 mEq/1
•)} 3.1-3.8 lZq/1
lot given
a) 3.8-165 pp»
b) 20-137 ppi
c) 5.4-71 pp.
(KIT
HEAR
a) 3.76 tor- 0.57
BES/1
b) 3.85 tor- 0.67
»Eq/l
c) 3.72 tor- 0.46
•Eg/i
d) 3.89 tor- 0.61
11 Eq/1
e) 3.75 tor- 0.48
»Eq/l
f) 3.47 tor- 0.29
»Bq/l
g) 3.62 tor- 0.41
• Eq/1
h) 3.70 tor- 0.39
.Eq/1
i) 3.61 tor- 0.29
•Eq/1
}) 3.47 tor- -0.24
•Eg/1
4000 tor- 3200 pp«
dry »t
-
a) 42 + OE- 32 ppB
b) 56 +or- 40 ppa
c) 33 +or- 22 pp»
P4GEI
GE8EEAL IKFOSHtTIOH
a) Before therapy, patients to
initially recei e liquid snppleients
b) 40 .Eg/day a K-gluconate
solution, at 2 K
c) 40 lEg/dar, s K-glaconate
solution, at 4 k
d) 48 lEg/dat, s KC1 tablet, at 6 vie
e) 48 .Eq/day, s KC1 tablet, at 8 wk
f) Before thera ;, patients to
initially recei e tablets
g) 48 lEg/day a KC1 tablet, at 2 »k
h) >8 «Eq/day a Itcl tablet, at 4 «k
i) 40 lEg/dar a K-glaconate
solution, at 6 k
•)) 10 mEq/iay a K-gluconate
solution, at 8 vk
•o significant differences between
levels with the two for.s. Not all
patients adhered strictly to regiien.
Hypertension patients, 43-67 yr olds
1DDLTS; UIPERTEBSIOII; BLOOD SEBOK;
niORETICS; POT1SSIUH
Rorial tissue
Japan
TOSGOE; ZIBCOKIOH; Z1EHEVT5; JiPiH ;
IDOLTS; JOTOPSIES; 1DBE»»L GLUHOS;
»CBT»; BORES; BEiBT; IHTESIKES;
KIDNEYS; IKES; LDHGS; LTHPH ROOES;
SPLEEN; PIBCBE1S; STOHiCH; THTEOID
GLANDS; TKACHEJ; iLDHINUll; BtSIOK;
C1DHIOII; CtLCIDI; CHEOBIOn; COBALT;
COPPER; IKON; LEIO; HISHESIOR;
RARGIHESE; NBTILS; ROLIBDIROR;
NICKEL; PHOSPHOBOS; POTASSIOB;
SILICON; SILTEB; SODinR; STBORTIOR;
Til; TITS »I OB; TANADIOH; ZIRC;
BIOACCTBOLiTION; HEALTH HAZ4BDS;
OCCOP1TIOBAL BAZABDS
a) 12 c. length, 104 sa.ples
b) Hoot section, 18 samples
c) Distal section, 18 samples
Hetropolitan Bombay, India
INDIA; ADOLESCENTS; ADOLTS ; HA IB;
ANTIBONT; AE5ERIC; BBOBINE; CADBIOB;
CBLOBINE; CBEOBIOB: COBALT; COPPER;
GOLD; IODINE; IBOR; LARTBAIDR;
BJBGANESE; POTASS HJB; SC&RDIUR;
SBLENIOn; SILVER; SODIOB; ZINC; AIB
POLLUTION; BIOACCURULATIOS; FOSSIL
FOELED POKES PLARTS; IRDDSTBIAL
AEEA3; IBDOSTBI1L HTBOSPBEEES ;
INDOSTBIAL E8ISSIORS; INDOSTBIll
POLLUTION; POPRLATIOR EIPOSOBE; DBBAR
ABEAS; INDOSTBIAL CHEBICALS
1EFEBEHCE
Hutchison, J. C.
197»
Journal of Clinical
Pharnacology
14(11/12) :624-629
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
Bhat, It. 9.
Aruaachala** J*
Tegnasubralianian, S.
Gangadharan, S.
1982
Science of the Total
Environment 22:169-178
-------
Pctassiui
•7HKO-09-7
t
At» 39.098, IP 63.2 C, BP 765.5 C. ?P tOO •« Hg at 590 C
(CONTINUED)
TISSUE
6689
React
6690
Intestine
6691
Kidney
EZPOSUBE BOOTE
__
ANALYTICAL
BETHOD
ES
ES
ES
JOBBER
OF CASES
8
10
8
BANGE
lot given
•ot given
Not given
BEAM
9100 +or- 1700 ppa
dry wt
5200 tor- 1800 ppi
dry »t
7000 *or- 810 pp« dry
vt
GENBBAL INFOBBATION
Norial tissue
Japan
TONGUE; ZIBCONIUH; ELEBENTS; JAPAN;
ADULTS; AUTOPSIES; ADEENAl GLANDS;
AOBTA; BONES; HEABT; INTESTINES;
KIDNEYS: LI'tB; LUNGS; 1IBPH NODES;
SPLEEN; PANCBEAS; STOHACH; TRYBOID
GLANDS; TEACHEA; ALUMINUM; BABIUR;
CADHIUH; CALCIUH; CHBONIOH; COBALT;
COPPEB: IBON; LEAD; HAGNESIUB;
BANGANESE; BBTALS: MOLYBDENUM;
NICKEL; PHOSPHOR OS; POTASSIOB;
SILICON; SILVER; SODIUB; STRONTIUM;
TIN; TITANIUM; TANADIUB; ZINC;
BIOACCOBULATION; HEALTH RAZAEDS;
OCCUPATIONAL HAZABDS
_. -
Normal tissue
•ean of stoiach and intestine
Japan
TONGUE; ZIRCONIUB; ELEMENTS; JAPAN;
ADULTS; AUTOPSIES; ADBENAL GLANDS;
AOBTA; BONES; HEABT; INTESTINES;
KIDNEYS; LITER; LUNGS; LIB PR NODES;
SPLEEN; PANCfiEAS; STOHACH; THYBOID
GLANDS; TESCHEA; ALDBINUH; BARIOM;
CADHIUB; CALCIUB; CHEOBIOB; COBALT;
COPPEB; IBON; LEAD; BAGNESIDB;
MANGANESE; BBTALS; HOLIBDENOH;
NICKEL; PHOSPHOR OS; POTASSIOB;
SILICON; SILVER; SODIUB; STBONTIOH;
TIN; TITANIOH; TANADIUB; ZINC;
BIOACCUBULATION; HEALTH HAZABDS;
OCCUPATIONAL HAZABDS
No»al tissue
Japan
TONGUE; ZIRCON 10 B; ELEMENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AOBTA; BONES; HEAKT; INTESTINES;
KIDNEYS; LIVER; LONGS; LIBPH NODES;
SPLEEN; PANCBEAS: STOBACH; TRYBOID
GLANDS; TRACHEA; ALUBINUB; BA8IOB;
CADHIUB; CALCIDH; CHROBlOB; COBALT;
CCPPES; IKON; LEAD; 9ACKBSIOB;
BANGANESE; BETALS; BOLTBDENOB;
NICKEL; PHOSPHOBOS; POTASSIOB;
SILICON; SIHEB; SODiaS; STSONTIUH;
TIN; TITANIDK; VANADIUM; ZINC;
BIOACCOBOLATION; HEALTH HAZABDS;
OCCUPATIONAL HAZABDS
BEFEBENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(») : 155-165
Teraoka, H.
1981
Archives of
36 (»): 155-165
Teraoka. H.
1981
Archives of
36(1) : 155-165
(NEXT PAGE)
-------
Potassium
7DHO-09-7
K
its 39.098, HP 63.2 C, BP 765.5 C, VP 100 mi Hq at 590 C
(CONTINUED)
6692
liver
6693
Lung
6691
Lymph
node
EXPOSURE FOOTE
ANALYTICAL
METHOD
ES
ES
ES
NUBBEB
OF CASES
9
12
3
RANGE
Not given
Mot given
Mot given
(BEIT
DEAN
7200 »or- 1300 ppB
dry wt
7100 *or- 1200 ppn
dry »t
13000 + or- 4500 pp»
dry »t
PAGE)
GENERAL INFORMATION
Normal tissue
Japan
TONGUE: ZIHCONIDB; ELEBENTS; JAPAN;
A DOLTS; AUTOPSIES; ADRENAL GLANDS;
AOBTA; BONES; HEiET ; INTESTINES;
KIDNEYS; LIVER: LUHGS; LYflPH NODES;
SPIEEM; PANCREAS; STOH4CH; TBTROID
GLANDS; TRACHEA; ALDSIHOB: BARIOH;
CADBIOB: CALCinn; CBBOfllOB; COBALT;
CCPPER; IBO»: LEAD; BAGNESIOBj
BAHGABESE; BETALS; BOLrBDEHOB;
SICKEL; PHOSPBOSOS; POIASSIOB;
SILICON; SILVER; SODI09; STRONTIOB;
UN; TITANIOB; VABADIOB; ZINC;
BIOACCOBOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
Noraal tissue
Japan
TOHGtJE; ZIBCONIUBJ ELEBEMTS; JAPAN;
ADOLTS; AUTOPSIES; ADRENAL GLANDS;
AORTA: BOMIS; HEART; I1ITEST1SES:
KIDNETS; LIVER: LONGS; LYBPH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLINDS; TRACHEA; ALOfllNOH; BARIOB;
CAdBInn; CALCIHB; CHROBIDB; COBALT;
COPPER; IRON: LEAD; BASNESIOB;
BANGANESE; BETALS; BOLYBDENDB;
NICKEL; PHOSPHOSOS; POTASS IBB;
SILICON; SILVER; SODIOH; STRONTIDB;
TIN; TITANIOfl: VASADIOB: ZINC;
BioAccoanLATios ; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
NorBal tissue
Japan
TON60E; ZIRCOBlnfl; ELEBENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEART; INTESTINES:
KIDNEYS: LIVER; LONGS; LHPH NODES;
SPLEEN; PANCREAS; STOBACH; THYROID
GLiBDS; TRACHEA: ALD8I1TOB; BURIDB:
CADHIUB; CALCIDB; CHROBIDB; COBALT;
COPPER: IRON; LEAD; BAGNESIUB;
BAHSANESE: H2TALS; BOLtBDEITOII;
NICKEL; PHOSPHORUS; POTASSIUM;
SILICON: SILVER; SODIUfl; STRONTIOB;
TIN; TITANinB; V»NADIUB: ZINC;
BIOACCUHOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(1) : 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(1) :155-165
Teraoka, H.
1981
Archives of
36 (»): 155-165
t-0
I—'
CD
-------
Fotassiui
HUD-09-7
f
ItB 39.098, BP 63.2 C, BP 765.5 C, VP 100 » Hg at 590 C
(CONTINUED)
TISSOE
6695
Pancreas
6696
Spleen
6697
Stoaach
EXPOSURE BOOTS
ANALYTICAL
METHOD
ES
ES
ES
HOB BEE
OF C1SES
5
9
10
BINGE
Not given
Not given
Not given
(NEXT
HEAH
7100 tor- 1<400 ppn.
dry wt
10000 *or- 2000 ppa
dry «t
5200 +or- 1800 pptt
dry wt
PAGE)
GE8ERIL IKFORBATIOS
Norial tissue
Japan
TONGUE; ZIRCONIOH; ELEBENTS; JAPAN;
AD01TS; AUTOPSIES; 1DREHAL GLANDS;
AORTA; BONES; HEART; IHTESTISES;
KIDHEYS; 1IVEE: LOM6S: LinPB NODES;
SP1EEH; PiNCBElS; STOBACH; THYROID
GIUHDS; TCiCHEt; JLDHI NOH; BAEI05;
CADBIOH; CUCIOB; CHROBIOH; COBALT;
COPPEE; IRON; LEAD; BIGSESIOB;
BAHGANESE; DETALS; BOLTBDENOB;
HICKEL; PHOSPHOSOS; POTASSIOB;
SILICON; SILVER; SODIOB; S1RONTIOM;
TIN; TITABIOB; 7AN»DIOM; ZINC;
BIOACCOBOLATION; HEALTH HAZARDS;
OCCUPATIONS HAZABDS
Noc«al tissue
Japan
TOBGOE; ZIRCONIOB; ELEBENTS; JAPAN;
ADOLTS; AOTOPSIES; ADBENAL GLANDS;
AORTA; BOHES; HEART: ISTESTISES;
KIDNEYS; LITER; LONGS; LYBPH NODES;
SPLEEN; PANCREAS; STOBACH; THYEOID
GLANDS; TRACHEA; ALOBINOH; BASIOI1;
CAOBItTB; CALCI0B; CHROBIOH ; COBALT;
COPPER; IRON; LEAD; BAGNESWH;
BANGANESE; BETALS; HOLYBDENOn;
NICKEL; PHOSPHOROS; POTASSIOB;
SI1ICON; SILVER; SODIOB; STROHTIDN;
TIS; TTTAMIOB; VANADIOB; ZINC;
BIOACCDHnLATIOH; HEALTH HAZARDS;
OCCOPATIONAL HAZARDS
Nocaal tissue
•ean of stoaach and intestine
TONGOE: ZIHC08IUB; ELEBENTS; JAPAN;
ADULTS; AOTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEAET; INTESTINES;
KIDNEYS; LI?EE; LONGS: LYBPH NODES;
SPLEEN: PANCREAS; STCBACH; THYEOID
GLANDS; TRACHEA; ALOBINOB; BARIDB:
CADBIOB; CSLCIOH; CHROBIUH; COBALT;
COPPER; IRON; LEAD; HJGHESIOB;
HANGANESE; BETALS; BOLYBDENOB;
NICKEL; PHOSPHOROS; POTASSIOfl;
SILICON; SILVER: SODIOfl; STRONTWH;
TIN; TITANIOB; VtNADIOB; ZINC;
BIOACCOBOLATION; HEALTH HAZARDS;
OCCOPATIONAL HAZARDS
REPERENCE
Teraoka, H.
1981
Archives of
36(1): 155-165
Tecaoka, H.
1981
Archives of
36(«): 155-165
Teraoka, H.
1981
Archives of
36(
-------
fotassiua
74110-09-7
K
At» 39.098, DP 63.2 C. BP 765.5 C, TP 100 •• Bg at 590 C
(COHTIBBED)
TISSOE
6698
Thyroid
gland
6699
Tongue
6700
Trachea
EXPOSURE ROUTE
ASALITICAL
BETHOD
ZS
ES
IS
IUBBER
OF CASES
4
2
2
BABGB
lot given
Hot given
lot given
BEAM
3300 tor- 560 p;n dry
lit
6200 -foe- 710 ppM dry
vt
3600 »or- 1100 pp«
dry wt
GEIEBAL IHFORBATIOH
florial tissue
Japan
TOVGOE; ZIBCO1IIDH; ELEBEHTS; J»P«H;
ADOLTS; AUTOPSIES; »DEE8AL SLIROS;
«08T>: DOPES: HE1BT; IHTBSTIHES;
KIDHEIS; LIVEB; ITOGS; LIBPH MODES;
SPLEEN; PKC8EIS; STCBiCH; TBTROID
GllUDS; TBACBEA; ILBBIBtTe; B1SIBH;
ODHIOM; C1LCIOB; CHBOHIDH; COBALT:
COPPER; IROS: LEAD; BACHES JOB;
BAIGA1ESE; BETALS; nOLIBDEIDB;
IIICKEL; PHOSPHORUS; POTASSIOB;
SLLICOH; SILVER; SODIOB; S1ROBTHJB;
Til; TITAHIOII; TAHADIDB; ZIKC;
BIOACCUBOLATIOH; HEALTH BAZABDS;
OCCDPiTIOHAL BAZABDS
lonal tissue
Japan
.TCISDE; ZIRCODIOB; ELEB2HTS; J APAB ;
ADULTS; AUTOPSIES; AD8EHAL GLADDS;
AOETA; BOHESi HEART; IBTESTIBES ;
KIDIEIS; LITES: LUHGS; LTBPH BODES;
SPLEBB; PABCEEAS; STOHACB: THYROID
GLAICDS; TRACHEA; AtOMlTCFn: BASIVH;
CADBIDN; CALCIOH; CHROBIHB; COBALT;
COPPEB; IBOI: LEAD; BAGBESIOB;
(IABGAIISE; BETALS; HOLTBDEIUH;
IICKEL; PROSPBOBUS; POTASSIDB;
SILICOX; SILVER; SODIOB; STROHTIDB;
Til; TITABIU8: VABADIDB; ZIBC;
BIOACCOBULATIOK; HEALTH HAZABDS;
OCCUPATIONAL BAZABDS
Vorval tissue
Japan
TOHGDE; ZIBCOHIOB; ELEBEDTS: JAPAX;
ADULTS; AUTOPSIES; ADREHAL GLADDS;
AORTA; BODES; HEART ; IHTESTISES;
KIDIETS; LITER; LOHGS; LIBPH (ODES;
SPLEEB; PAUCBEAS; ST08ACR; THTBOID
CLAUDS; TRACHEA; ALUHimTR; BAKIUH;
CADBIUB; CALCIUB; CBBOBIDB; COBALT:
CCPPEB; I BOB; LEAD; BAGRESIDB;
BAIGAIESE; BETALS; BOLIBDEiOB;
IICKEL; PHOSPHOBOS; POTASSIOB;
SILICOX; SILVEE; SODIUB: STROHTIOB;
TIR; TITmiaB; VABADIOB; ZIK;
BIOACCOHOLATIOH; BEALTH HAZABDS;
CCCOPATIOIAL HAZABDS
BEFERESCE
Teraokaf H.
1981
Archives o£
36(*): 155-165
Teraoka, H.
1981
Archives of
36(»): 155-165
Teraoka , H*
1981
Archives of
Environmental Health
36(4): 155-165
K)
O
-------
Potassiui, isotope of lass (to
13966-00-2
>
B» 39.098, HP 63.2 C, EP 765.5 c (also reported as 771 C)
TISSUE
«701
Body
BXPOSUBE ROUTE
AHAIITICAL
BETHOD
Radioietry
HOIBEB
or CASES
68
BADGE
a) lot given
b) Hot given
c) Hot given
d) Hot given
BEAH
a) 2.22 *or- 0.21
g/*g
b) 2.60 *or- 0. 19
g/kg
c) 2. »0 »or- 0. 15
g/fcg
d) 2.71 «or- 0. Ht
g/kg
GEHBBAl IMFOBBinOH
a) Rhole body •easureaent, urban
residents
b) Pat-free mass, urban residents
c) Hhole body Measurement, rural
residents
d) Fat-free mass, rural residents
12-19 yr old Japan
boys
JAPAH; CKXLDREH; BOOT; CORP1RATIVE
ETtLUtTIOHS; IH TITO »»»LTSIS;
POTiSSIOfl; DSBiH 1REIS
REPEREHCE
Anzai, I.
Sakaaoto, K.
Togo, fl.
Katsunuia, H.
1981
Annals of Haaan Biology
8(2) .-109-117
Propane, 2-nitro-
79-K6-9
C3-H7-H-02
HH 89.09, BP 120 C, TP 10 I] Hg at 15.8 C
6702
Breath
EIPOSOBE ROOTE
AHAIITICAL
METHOD
» OH BEE
OF CASES
O.lt-1.3 ng/1
BEAH
0.7 ng/1
GEHEBAL INPOB BATICH
Estiaated froa graph
Healthy 18-60 yr olds, nonsnokers.
Rigid protocol 14 days before and
during stady to aininize nuBber and
amount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORIHE
ORGAHIC COHPOOHDSJ CHIOROBEHZEHI5
-
REFEREHCE
Krotoszynski, B.
Gabriel, G.
O'Neill. H.
Clandio, I), p. A.
1977
Journal of
Chroaatographic Science
15:239-21"
K)
Propionic acid, 3-mercapto-, ethyl ester (8 CI)
Propanoic acid, 3-aercapto-, ethyl ester (9 CI)
ei66-06-8
C5-H10-02-S
UK 134.21
TISSDE
6703
Breath
EIPOSDF.E H001E
ANALYTICAL
METHOD
GC/BS
NUBOEB
OF CASES
28
BADGE
2.2-5.7 ng/1
BEAH
--
1 ng/1
GEBERAL INFORtllTIOH
Estimated from gcaph
Healthy 18-60 yr olds, nonsaokers.
Bigid protocol 14 days before and
during study to minimize number and
amount of exogenous constituents.
AD0LTS; BRC&TH; ALCOHOLS; CHLORINE
ORGANIC COHPOONDS: CHLOROBENZENES
Gabriel, G.
O'Heill, H.
Clandio, B. P. A .
1977
Journal of
chroaatographic Science
15:239-241
-------
Cropiophenone (8 CD
1-Propanone, 1-phenyl- (9 CI)
93-55-0
C9-H10-0
B» 131.2, HP 21 C, BP 218.0 C, VP 1 •• Hg at 50.0 C
6701
Breath
EXPOSURE BOUTS
ANALtTICAL
BETBOD
GC/BS
BOBBER
OF CASES
0.12-1.5 ng/1
0.4 ng/1
1 GENEBAL INFORHATION
1
Estimated Scorn graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 14 days before and
during study to minimize number and
amount of exogenous constituents.
ADULTS; BBEATH; ALCOHOLS; CHL08INE
ORGANIC COBPOUNDS; CHLOROBE»ZENES
REFERENCE
Krotoszynskl, B.
Gabriel, 6.
O'Neill, B.
Claudio, S.P. A.
1977
Journal of
Chromatographic Science
15:239-21*
Fsendohexyl alcohol
2-Ethylbutanol
2-Ethylbatyl alcohol
2-Ethyl-1-butanol
3-aethylolpentane
97-95-0
C6-HU-0
BB 102.17, IIP -15 C, BP 118.9 C, VP 0.9
II Hg at 20 C
TISSUE
1
6705
Breath
EXPOSURE ROUTE
ABallTICAL
BETHOD
GC/BS
HOB BEE
OF CUSES
28
BANGS
O.H3-2.3 ng/1
SEAS
1 ng/1
GESEBAL INFOEBATIOH
Estiiated from graph
Healthy 18-60 yr olds, nonsiokers.
Rigid protocol 14 days before and
during study to liniilze nuiber and
anoont of exogenous constituents.
ACOLTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COBPOOBDS; CHIOROBENZEBES
REFERENCE
Krotoszynski, B.
Gabriel, 6.
O'Neill, H.
Claudio, B. P. A.
1977
Journal of
Chroiatographic Science
15:239-244
1
- .- - - 1
KJ
Pyrene
129-00-0
C16-H10
BI 202.24, RP 156 C, BP 404 C
TISSUE
6706
Adipose
6707
LiTer
BtPOSDBE ROOtE
AHALITICAL
HETBOD
HPX.C
HPtC
IOBBER
01 CUSES
10
6
BADGE
.
49-2700 ppt net vt
270-470 ppt vet lit
HE AH
1140 ppt net «t
383 ppt vet vt
GENERAL IHFOBBATION
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CBEBICALS; JAPAN;
AUTOPSIES; ADIPOSE TISSUE; LIVER;
POPULATION HIPOSURE
Autopsies
27-66 yr olds, Japan
INDUSTRIAL CHEBICALS; JAPAN;
AUTOPSIES; ADIPOSE TISSUE; LIVES;
POPULATION EXPOSURE
_..
REFERENCE
Obana, H.
Hori. S.
Kashiioto, T.
Knnita, N.
1981
Bulletin of
Environmental
Contamination and
Toxicology 27:23-27
Obana, H.
Hori, S.
Kashiaoto, T.
ICunita, N.
1981
Bulletin of
Environmental
Contamination and
Toxicology 27:23-27
-------
Badiui
7«ao-HI-l|
8a
»t» 226. HP 700 C, BP 1110 C (also reported as 1737 c)
6708
Body
6709
Bone
6710
Lung
EXPOSURE BOOTS
A NAUTICAL
BETBOD
KtU BEE
OF CASES
GENERAL IHFORHJTION
Beviev. Clinical and autopsy
findings, subjects surviving 25 yr
after first industrial exposure to
Ra-226 and Ba-228
KlCIDII; NEB JERSET; AUTOPSIES; CASE
HISTORIES; ANEKIA; CARCINOHAS;
OCCUPATIONAL DISEASES; ORAl DISEASES;
OSTEOS\RCOS»S; BODT; BOBES; LUNGS;
RETIEB; INDUSTRIES; OCCUPATIONAL
H12ABDS; P1IHTS; BUDIATIOS DOSES:
E»DIO»nCLIDES
Beview. Clinical and autopsy
findings* subjects surviving 25 yr
after first industrial exposure to
Ba-226 and Ba-228
HE» JERSEY; AOTOPSIES; CASE
HISTOSIES; ASEfllA; CARCIHOBAS;
OCCOPHTJOBAL DISEASES; OBAL DISEASES;
OSTEOSARCOflAS: BODT; BODES; 1UH6S;
BETIEK; IHDOSTBIES; OCCOPATIOMAL
HilAKDS; PAIDTS; BkOUTIOS SOSES;
BADIOSOCLIDE5
Bevie«. Clinical and autopsy
findings* subjects surviving 25 yr
after first industrial exposure.to
Ba-226 and Ba-228
BADIDM; NED JERSEI: AOTOPSIES: CASE
HISTORIES; AHEHIJ; CAPCINOBA5;
OCCOPATIONAL DISEASES; ORAI DISEASES;
OSTEOSJECOBAS; BODI; BONES; LONGS;
SETIES; IUDDSTBIES; OCCOPATIONAl
HAZARDS; PAINTS; RADIATION DOSES;
RADIOHUCLIDES
Sharpe, B.D.
19711
Environmental Research
8:213-383
Sharpe* H.D.
1974
Environmental Research
8:2«3-383
Sharpe, W.D.
19711
£nvii:onK«Dtal Research
8:2«3-383
Eutidiun
7UUO-17-7
AtW 85.H678, HP 39 C, BP 688 C. vp 10 » Hg at 390 C
TISSUE
6711
Blood,
whole
EXPOSURE ROUTE
ANALYTICAL
HETHOD
I-Ray
Spectroietry
SDKBEB
OF CASES
27
BASSE
-
Not given
0.9 ppm
GENERAL INFORHATION
Precision 19*
ELOOD; 8EASOBEHE11T BETBODS; COPPER:
IBOS; METALS; BDBIDIOH; SELENIDH;
zinc
(NEXT PASE)
Bearse, B.C.
Close, D.A.
Halanify. J.J.
Oabarger, C.J.
197»
inaljticsl Chemistry
«6(«): 199-503
-------
Rubldiui
TWO-17-7
Bb
AtB 85.U678. IIP 39 C. BP 688 C, If 10 » Hq at 390 C
(COHTIHOED)
TISSUE
__._
6712
liver
EXPOSURE ROUTE
-
ABALITICAL
BETHOD
IA
KOBBEB
or CASES
30
BINGE
7-12 ug/g
II et «t
HE1S
Not given
GESERAL IHFORHATIOII
Category 2 as proposed by
International workshop on Monitoring
Banking (non-pollutant trace element
•onitored foe "normal" levels)
Autopsies, Baltimore, BD,
Binneapolis* BH, and Seattle, HA
BARTLAHD; lUHHESOTA; BiSfllFGTON;
soTopsiBS; iiren: HEJSOBEBZMT
HETRODS; JLOniHOII; tHTIKOHI; 1BSEHIC;
EJEIOB; ciDiunn; CHBODIOB; COBALT;
CCPPIB; FLOOBISE; IBOS ; LEID;
BUGABESE; BEECH El; flOLIBDEBOB;
IICKEL; RUBIDIUB; SELEHIIKI; SILVEC;
STBOITIOH; THALLIOT; TIK; fAKJOIOB;
ri»C; POPOLATION EXPOS OB E
BEFEEEKCE
Harrison, S.R.
Zeisler, E.
Rise, s . &•
1981
EP1 600/S1-81-025, 6
pp.
Salicylic acid, ion(l-) (8 CI)
Benzole acid, 2-hydcoiy-, ion(l-) (9 CI) (?«H)
63-36-5
C7-H5-03
K« 138.12, HP 157-159 C, BP about 211 C at 20 •• Hg
6713
Blood
EXPOSURE ROUTE
AI1LTTICIL
BETHOD
GC
TLC
nt
GC/BS
Enzyaatic
HDBBEB
OF C1SES
2
B1BGE
Trace- 17 t »g/l
BEAI
Not given
GENERAL IHFOBHATTON
Dose probably less than toxic aaoant
identical samples for toxic screen
of cases
Laboratories agreed on 6 of 23 drugs
re for ted present in seen* of 20
patients
Levels Mere variable and appeared
in-precise.
Probable drag overdose patients.
Boston, Rft
1USS4CHBSETTS: BLOOD; HAIGESICS;
AITICOHVOLS1HTS; MTIDEPBESSITE
1GOITS; AKTIPI8ETICS; DBOG ABUSE;
BKOS5; HTPJOTICS: H1BCOTICS;
SEDATIVES; TBAHQOILIZEBS; COBPABATITE
ETAtDATIOIS; ALCOHOLS; BEASOBtBZKT
BETBODS
BEPEREHCE
Ingelfinger, J.i.
Shine, D.
Costel lo , C » E •
Goldian, P.
1981
Clinical Pharmacology
and Therapeutics
29(5):570-575
-
KJ
-------
Scan dim
7440-20-2
Sc
»ti 44.9559, DP 1538 C, BP 2832 C
TISSUE
67 1»
Hair
6715
Hair
6716
Kail
EIPOSUBE BOOTE
AIALITICAL
BETBOD
•A
BJ
8A
.
BOB BEE
OF CASES
»5
..
61
BAIGE
10-40 ng/g
a) 0.002-0.04 ppi
b) 0.005-0.04 pp<
c) 0.004-0.04 ppi
50-680 ng/g
HE41
Hot given
a) 0.012 »or- 0.010
PP«
b) 0.016 tor- 0.01
pp»
c) 0.02 tor- 0.002
PP«
Not given
GEIERIL IKOBBATIOH
ttange of means, estimated from graph
Alexandria, Egypt
EGIPT; HAIB; HAILS; AHTISOHY;
CADBIOB; CESIUH; CHBOBIUB; COBALT;
IEOB; BAHGAHESE; HETALS; BOLYBDEHUB;
SCAHDIUfi; 5ELEHIUH; SILVER; TUIGSTEH;
ZIBC; DBINKIHG RATER; POPULATIOH
EXPOSUBE; SOILS; UBBAH ABEAS
a) 12 cm length, 98 samples
b) Root section, 18 samples
c) Distal section, 18 samples
Betropolitan Bombay, India
IBDIA; ADOLESCENTS; ADULTS; HAIB;
AHTIBOHT; ABSEHIC; BROB.IHE; CADIIUB;
CHLORIHE; CHBOBIUH; COBALT; COPPEB;
GOLD; IODIBS; IBOB; LABTHABUB;
BAHGAHESE; POTASSIDfl; SCAIDIDB;
SELEHIDB; SILVER; SODIOH; ZIBC; AIR
EOLLUTION; EIOACCOBULATIOH ; FOSSIL
FUELED POSER PLAITS; IHDUSTBIAL
ABEAS; INDUSTRIAL ATBOSPHEBES;
INDUSTRIAL lflISSIO!IS; IHDOSTRIAL
POLLUTION; POPULATIOH EXPOSOBE; UBBAB
IBEAS; INDUSTBIAL CREBICALS
Bange of means, estimated from graph
Aswan, El Kharga, Assuit, Cairo, and
Alexandria, Egypt
EGYPT; BAIB; HAILS; AHTIBOHY;
CADBIUB; CESIUB: CHBOBIOB; COBALT;
IBOB; BAHGAHESE; BETALS; BOLIBDEIU8;
SCABDI0B; SELEHIUfl; SILVEB; TUIGSTEH;
ZIHC; DBIHKIHG WATER; POPULATIOH
EXPOSUBE; SOILS; ORBAH ABEAS
BEFE
Kasperek, K
lyemgar, G.
Hashish, S.
Kahfouz, B.
1982
Science of
Environment
Bhat, K.B.
Aronachalam
Yegnasubram
Gangadharan
1982
science of
Environment
Kasperek, K
lyengac, 6.
Feinendegen
Hashish, S.
Bahfouz. B.
1982
Science of
Environment
V.
the Total
22:149-168
, J.
anian, S.
, S.
the Total
22:169-178
f.
, L.E.
the Total
22:149-168
NJ
NJ
(Jl
Seleniun
7782-49-2
Se
»t» 78.96, BP 170-217 c, BE 685 C, VP
1 » Hg at 356 C, 10 la Hg at 429 C
TISSUE
6717
Aorta
EIPOSUBE BOUTE
AIALITICAL
BETHOD
HA
H OH BEE
OF CASES
a) 3
M 3
C) 3
d) 6
«) 7
l\ ^
BADGE
a) 0.79-1.72 ug/g
b) 0.82-1.08 ug/g
c) 0.87-1.32 ug/g
d) 0.93-2.78 ag/g
e) 0.82-1.87 u9/g
f) 0.38-1.65 ug/g
Dry lit
(BEIT PAGE)
HEAH
a) 1.20 *or-
ug/g
b) 0.96 «or-
ug/g
c) 1.07 +or-
ug/g
d) 1.67 tor-
ug/g
e) 1.23 »or-
ug/g
f) 0.95 tor-
ag/g
Dry vt
0.22
0.02
0.05
0.68
0.32
0.43
GEBEBiL INFOEBATIOS
a) Hornal intiaa, nedian 1.09 ag/g
b) Rornal edia, aedian 0.98 ag/g
c) (anal dventitia, ndian 1.01
ng/g
d) Atheron intiia, median 1.58 ng/g
e) Atheroa nedia, median 1.20 ug/g
f) Atheroi adventitia, median 0.92
ag/g
Ho knovn selenium exposure
1 day-79 yr old, autopsies
AGE; AUTOPSIES; AOBTi; BBOBIIE
REFEBEHCE J
1
-
cross, J.D.
Bale, B.B.
S.ith. R.
1981
Journal of clinical
Pathology 34:393-395
-------
seleniui
7782-19-2
Se
At« 78.96, HP 170-217 C, BP 685 C, VP 1 »i Kg at 356 C, 10 » tig at 129 C
{CONTINUED)
TISSUE
_.. _._
6718
Biooa,
6719
plasia
6720
Blood,
platelets
EXPOSURE ROUTE
Ingestion
AHALTTICAL
HETHOD
111
HA
HA
HUBEEB
0? OSES
a) 20
b) 20
d) 10
e) 30
f) 30
a) 20
c) 10
d) 10
e) 30
t) 30
a) 10
b) 8
BINGE
..
a) Hot given
b) Not given
d) Hot given
e) Hot given
f) Hot given
a) Hot given
c) not given
4) Not given
e) Hot given
t) Hot given
a) 700-150 ng/g
b) 400-150 ng/g
BEAH
a) 440 or- 90 nj/g
b) 469 or- 70 ng/g
d) 470 or- 60 ng/g
e) 558 or- 112 ng/j
f) 571 or- 109 ng/j
Dry lit
a) 972 +o - 372 ng/g
c) 908 +o - 283 ng/g
d) 872 +o - 307 ug/g
e) 1210 + r- 382 ng/g
f) 1190 + r- 364 ng/g
Dry lit
a) Not given
b) Not given
GENERAL INFORFIATION
aj Adults, cardiovascular disease,
urban area
c) Adults, cardiovascular disease,
rural area
hypertensives, urban area
f) Controls for e)
Brythrocytes
Adults, mean age 55 yr, and students,
Chatham and Evans counties, GA
Depressed erythrocyte glutathione
feroxidase
CACHinn; METALS; SELENIUM; RURAL
AREAS; 0RBAN ABBAS; GEORGIA;
CfcBDIOTlLSCULAR DISEASES;
HYPERTENSION; BLOOD; BLOOD PLAStlA;
ERYTHROCYTES
a) Adults, cardiovascular disease.
b) Controls for a)
c) Adults, cardiovascular disease,
rural area
d) Controls for c)
e) High School seniors.
f) Controls for e)
Levels lover than those for residents
of nidvestern O.S.
Adults, nean age 55 yc, and students
Depressed erythrocyte glutathione
peroxidase
CADHIOB; BETiLS; SELENIUfl; SOB1L
IBEaS; URBAN 1EEJS: GBOBGIi;
CAEDIOVASCOLA8 DISEASES;
HIPEBTENSIOH: BLOOD; BLOOD PLlSnA;
ESrTBKO CITES
a) 1.5-9.5 ;r old controls* before
breakfast
b) 2.5-7.8 yr old patients, lov Se
diet
Estimated fro* graph
Platelet Se levels below nonal (600
erythrocytes and plasia very low
6 children Kith phenylketonuria, 2
vith Haple-syrup-urine disease, and
controls.
SELZNIOB; NOTBITIOHAL DISOBOERS;
BIOOD; PIHE1ETS; CEIIDEEK;
EBTTHBOCT^ES; BIOOD BliSSi
BE7E8EHCE
tndrevs, J. «.
Hates, C.G.
Davis, J.H.
1980
Proceedings, University
of Missouri Annual
Conference on Trace
Substances iu
1«:33-«2
Andrews, J. if.
netts, J.c., Jr.
Davis. J.B.
1980
Proceedings, university
of Missouri Annual
Substances in
Environmental Health
14:33-»2
Kasperek, K.
Lonbeck, I.
Kiel, J.
lyengar, 6. T.
lang, Y.X.
Feinendegen, L'.E.
1982
Biological Trace
Element Research
(,:29-34
(HUT PAGE)
N3
NJ
-------
ScleninB
7782-49-2
Se
At» 78.96, IIP 170-217 C. BP 685 C, VP 1 •• Hg at 356 C, 10 » Hg at 429 C
(CONTINUED)
TISSUE
6721
Blood,
seruB
6722
Blood,
vhole
6723
Bone
6721
Hair
6725
Hair
6726
Hair
EXPOSURE ROUTE
Ingestion
_
ANALYTICAL
asiHOB
GC
J-Bay
Spectroietty
Hi
SI
_
HA
•It
NUBBEB
OF OSES
a) 8
b) 20
27
a) 7
b) 5
54
1
46
BADGE
a) 55-115 ng/al
b) 35-115 ng/al
Hot given
a) <0. 02-0. 58 ppa
b) <0. 06-0. 12 pp«
O.H6-0.52 ug/g
49.2X10 (E-6)-981.7I10(E-6
) g/cu CB
0.45-0.9 ng/g
HEAD
a) 78.2 +or- 19.2
ng/Bl
b) 55.0 *or- 16.8
ng/Bl
0.2 pp«
a) 0.040 ppm
b) 0.057 ppa
Medians
0.49 ug/g
237.34X10(E-6) g/cu
CB
Mot given
GENERAL INFORHATION
a) HUBan Bilk diet. Bean Se intake.
birth to 3 BO, 16.3 *or- 4.9 ng/tl.
Bean daily Se intake at 3 BO 10.08
+or- 2.96 ug/day
birth to 3 BO, 8.6 +or- 0.9 ng/Bl,
Bean daily Se intake at 3 BO 7.22
«or- 1.26 ug/day
a) significantly higher than b)
Se intake group a) significantly
higher than that of group b)
Bange estinated frOB graph
3 KO old infants, IL
ILLINOIS; ADULTS; INFANTS; BLOOD
SEEOH; SILK; HETALS; SBLBNinn; DIETS;
FOODS; LACTATION
Precision 50*
ELOOD; HEASDREHEliT HETBODS; COPPEB;
IBOS; flETALS; ROBIDIDII; SEIEHIOI;
ZIBC
a) Exposed group
b) Controls
Autopsies, feaur
Controls froB unpolluted areas
ANTinOlY; ABSEHIC: CADKIDK; COPPED;
LJAD; BEBCOBT; SELEBIOB; SILVER; TIH;
ZIHC; BIOACCOHDLATION; IKDDSTHIAL
ATHOSPHEEES; IHDHSTBIAL PLABTS;
POPtJLATIOH EXPOSOEE; SBELTEHS; BONES;
FEBDR; COBPARATIVE ETALOATIONS ;
SWEDEN: ADTOPSIES; OCCDPATIONAL
HAZARDS; HETALS
Bange of Beans, 5 localities
ADULTS; HAIB; ARSENIC; CADBIDH;
BEBCORT; BETALS; SELENIUK; ZIBC
3 CB segaents of single hairs
Soae sanples belov detection liaits
IBIDIDB; HAIB; FOEENSIC 8EDICINE;
lEAStlREBENT BETHODS; ANTIHONY;
AB5ESIC; BPOBISE; COPPER; GOLD;
HBTHAHOn; MANGANESE; BERCOHY;
BETALS; SELENIOB; SILVER; SODIOB;
STBOIITIOB; ZINC; INDUSTRIAL
ATBOSPHERES
Bange of Beans, estinated fro* graph
Aswan, El Kharga, Assnit, Cairo, and
Alexandria, Egypt
EGYPT; HAIR; NAILS; ANTINOMY;
IBON: BANGANESE; BETALS; BOLIBDEBOa;
SCANDIDM; SELENIDH; SILVER; TONGSTEN;
ZINC; DRINKING HATER; POPULATION
EXPOSURE; SOILS; OS BAN AREAS
REFERENCE
SBith. A.fl.
Picciano, a.F.
nilner, J.A.
1982
clinical Nutrition
35:521-526
Bearse, R.c.
Close, D.A.
flalanify, J.J.
Uabarger, c.J.
1974
Analytical Cheaistry
46(4) : 199-503
Lindh, U.
Brune, D.
Nordberg, G.
aester, P.-o.
Science of the Total
Environaent 16:109-116
Johannesson, T.
Lunde, G.
1981
Acta Phamacologica et
Toxicologica 48:185-189
Dybczynski, R.
Boboli, K.
1976
Journal of
Radioanalytical
Cheaistry 31:267-269
Kasperek, X.
lyengar, G.v.
Feinendegen, L.E.
Hashish, S.
nahfouz, n.
1982
Eniironaent 22:149-168
(NEXT PAGE)
NJ
NJ
-------
Selenium
7782-49-2
Se
At» 78.96. BP 170-217 c, BP 685 C, 7P 1 •• Hg at 356 C, 10 » Ug at »29 C
(CONTINUED)
6727
Rair
6728
Kidney
6729
Liver
EXPOSOBE EOOTE
ANALYTICAL
BETHOD
IA
Pluorometry
HA
HDHBER
OF CASES
123
30
.. _
BAHGE
a) 0.18-3.4 ppl
bj 0.56-2.68 pp»
c) O.U-2-53 ppm
a) Hot given
b) Hot giv n
c) Hot giv n
d) Hot giv n
e) lot giv n
f) Hot giv n
h) Hot giv n
i) Hot giv n
0.097-0.68 ug/g
»et vt
BEAH
a) 1.4 +or- 1.2 ppm
b) 1.32 +or- 0.58 ppm
c) 1.26 *or- 0.6 ppa
a) 1.1 or- 0.5 ug/g
b) 1.2 or- 0.1 ug/g
c) 1.2 or- 0.4 ug/g
d) 1.0 or- 0.4 ug/j
e) 0.8 or- 0.2 ug/g
£) 1.3 or- 1.2 U9/9
h) 0.7 or- 0.5 ug/g
i) 1.2 or- 0.5 ug/g
Hot given
GEHEB1L INFOB8ATIOH
a) 12 CB length, 95 samples
b) Boot section. Id samples
c) Distal section, Id samples
Metropolitan Boibar, India
INDIA; ADOLESCEHTS: ADULTS; HAIB;
ARTlnONT; ARSENIC; BBOHINE; CADnlDII;
CBIORIHE; CBBOBIOB; COBALT; COPPEB;
SOLD; IODIS!; ISOS; L1HTHAKIIH;
BAHGtHESE; POTASSIDB; SCAHDIDB;
SELEHIOB; SILVEH; SODIDB; ZISC; AIB
EOLLOTIOH; BIOACCOBOLATIOH; TOSSIL
FOELED POSEB PLAHTS ; IHDOSTBIAL
ABEAS; INDUSTRIAL ATBOSPBEBES;
IHDOSTBIAL BBISSIOHS; IHDOSTBIAL
POLIOTION; POPOLATIOH EXPOSURE; UBBAH
ABEAS; IHDOSTBIAL CHEBICALS
a) All cases
b) Hypertension, 35 cases
c) Atherosclerosis, 45 cases
d) Cancer, 32 cases
e) Cancer and Metastases, 16 cases
£) leukeiia, 7 cases
h) Benal disease, 4 cases
i) Other, 28 cases
Autopsies
Se/cd ratios greater in patients vith
smoking and nonsmoking patients
CADBIOB; KETALS; SELENIOt!; ZIHC;
CADA7EBS; CABCIHOBAS; ETPEBTEHSION;
KIDBEI DISEASES; LEOKEBIA; KIDHEIS;
SBOKIHG
Category 1 (first priority eleaent)
as proposed by International Workshop
co Booitocing Environmental gaterials
and specimen Banking
Autopsies, Baltimore, PD,
ninneapolis, RH. and Seattle, «A
.1ABIL4NO; BIHJIESOT1; RAS9IIIGTOII;
AOTOPSIES; LIVEE; HEASOBEBEHT
METHODS; AI.OBIHOB; AHTIflORT; AESEHIC;
EABIDB; CADBIOB; CBBOBIOB; COBALT;
COPPEB; FLUORINE; IRON; LEAD;
BARGAHESE; BEBCOBI; BOLTBDEHOB;
NICKEL; BOBIDIOH; SELEHIUB; SIL7EE;
STBONTIOB; TRALLIOD; TIN; VANADIOB ;
ZIIC; POPOLATION EXPOSURE
BEFEBEHCE
Bhat, K.B.
Arunachalam, J.
Tegnasuforamanian, S.
Gangadharan, S.
1982
Shamberger, B.J.
Bra tush, C.B.
1980
Proceedings, University
of Bissouri Annual
Conference on Trace
Environmental Health
14:203-210
Harrison, S.H.
Zeisler, B.
Rise. S.A.
1981
EPA 600/S1-81-025, 6
PP.
(HEX! PAGE)
OO
-------
Seleaiun
7782-49-2
Se
At» 78.96, HP 170-217 C, Sf 685 C. VP 1 •• Bg at 356 C, 10 •• Ug it 429 C
(COMINOBD)
6730
Bilk
6731
Nail
6732
Orine
EXPOSURE BOOTH
.
ANALYTICAL
BETHOD
GC
NA
FluoriBetry
NOHBtR
OF CASES
13
44
11
RA8GE
a) 8-34 ng/Bl
b) Not given
c) ot given
d) ot given
e) ot given
f) ot given
g) ot given
h) ot given
0.5-0.95 ug/g
a) 35-61 ng/Bl
b) 33-36 ng/ag creatinine
c) 33-63 ug
d) 19-248 ng/Bl
e) 26-240 ng/ig
creatinine
£) 7-95 ug
BEAU
a) 16.3 tor- 4.9
ng/Bl
b) 41.2 tor- 17.3
ng/»l
b) 15.7 tor- 4.9
ng/Bl
d) 16.3 tor- 4.8
ng/Bl
e) 14.4 tor- 1.6
ng/»l
f) 15.2 tor- 3.2
ng/Bl
g) 14.1 »or- 3.2
ng/Bl
h) 15.9 tor- 3.4
ng/Bl
Not given
a) 47 »o - 20 ng/Bl
b) 35 +o - 11 ng/ag
creatini e
c) 45 »o - 15 ug
d) 99 to - 28 ng/Bl
e) 95 to - 12 ng/ag
creatinine
f) 26 tor- 10 ug
GENERAL IHFORBATION
a) 8 nothecs, saipled 3x/day before
nursing, at 1, 2, and 3 mo postpartui
b) 4 Bothers, colostra* saiples froa
each breast, 1-4 days postpartui
c) saipled before nursing at 2 »k
lactation
d) Sampled after nursing at 2 wk
lactation
e) Saipled before nursing at 1 .0
lactation
f) Sampled after nursing at 1 BO
lactation
g) Sampled before nursing at 2 mo
lactation
h) Saapled after nursing at 2 mo
lactation
c)-h) 5 Bothers saipled 2x/day a) .and
t|, g) and hi differed, p <0.05.
Significant positive correlation with
protein content, r » 0.49
Additional data presented
Lactating aothers, 1 day-3 BO
postpartuB, IL
I1LINOIS; ADULTS: INFANTS; BLOOD
SBEDB; HILK; HETALS; SELENIDB; DIETS;
FOODS; LACTATIOB
Range of Beans, estimated fro« -graph
Asvan, El Rharga, Assuit, Cairo, and
Alexandria, Egypt
EGYPT; HAIS; NAILS; ANTIBONI;
CADBIOB; CESIOB; CHSOBIOB; COBALT;
IRON; BANGABESE; BETALS; BOLTBDEBUH;
SCANDIRB; SELEBIOB; SILVER; TOBGSTEB;
ZINC; DRINKING HATER; POPULATION
EIPOSBBE; SOILS; BE BAN ABEAS
a) 24 hr output, based on 7 saaples
(1 per Bonth) for 7 Months, 3
subjects
b) Saae as a) expressed in tens of
creatinine
c) saae as a), total Se output
d) Spot saaples taken over 24 hr in
subjects
e) Saae as d) expressed in teras of
creatinine
f) SaBe as d) , total Se output
Data presented in b) and e) subject
to least variation and dilution
effect.
JAPAN; URIBE; BEASOREBENT BETBODS;
HETALS; SELEBIOB
REFERENCE
SBith. A.B.
Picciano, n.F.
Bilner, J.i.
1982
Aaerican Journal of
Clinical Nutrition
35:521-526
Kasperek, K.
lyengar, G.V.
Feinendegen, L.2.
Hashish, S.
Bahfouz, B.
1982
Science of the Total
EnvironBent 22:149-168
Hojo, I.
1981
Bulletin of
EnvironBental
Contaaination and
Toxicology 27:213-220
-------
Silicon
HtHO-21-3
Si
AtH 28.086. BP 1010 C, BP 2600 C, TP 1 » Hg at 1720 C
6733
Id renal
gland
673»
Aorta
6735
Bone
EXPOSURE ROOTE
ANALYTICAL
METHOD
NOB BEE
OF CASES
7
7
5
BINGE
Hot given
Hot given
Hot given
BEAN
46 +or- 26 PPH dry wt
3» *or- 22 tfm dry «t
<10 PPB dry vt
GENERAL INFORSATIOH
Noraal tissue
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BORES; BEART;
INTESTINES; ItlDBEIS; LIVER; LONGS;
LTBPB MODES; P1NCBEAS; SPLEEN;
STOBACH; TBIROID G1ANDS; TBACHEA;
AIC8ISDB; BJBIOB; CiDBIDn; CJLCIOB;
CBROBIOM; COBALT; COPPER; IRON; LEAD;
BAGSESIOB; BtHGaHESE; BETA IS;
BCLTBDENOB; NICKEL; PHOSPHORUS:
POT1SSIUB; SI1ICOH; SILVER; SOPIOB;
STHONTIDB; TIN; TIT A SI OB; VIHADIUB;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOHSOE: ZISCOHIDB; ElEIEHTS
Horial tissue
Autopsies
OAPkli; ADDLTS; ADTOPSIES; ADEESAL
GLANDS: AORTA; BOUTS; HEART;
INTESTINES; ICIDHEIS; LITER; LONGS;
LY1PH NODES; PANCREAS; SPLEEN;
STOBACH; TBTEOID GLANDS; TRACHEA;
ALOBIHOB; BABIOB; CAOfllOB; CALCI08:
CHROBIOB; COBALT; COPPER; IRON; LEAD;
BAGSESIDB; BtNGANESE; BETALS;
aOLTBDESOB; NICKEL; PHOSPHOROS;
poTASsioa: SILICON; SIIVER; SODIOB;
S1BONTIOB; TIN; TIT A NI OB; 7ANADIOB;
ZINC; BIOACCOBOLATIOS; HEALTH
HAZARDS; OCCOPATIOB AL HAZARDS;
TONGDE; ZIRCONIDH; ELE BENTS
Noraal tissue
Autopsies
JAPAN; ADOLTS; AOTOPSIES; ADRENAL
GLAKDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LTflPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TBACHEA;
ALOBINUB; BABIOB; CADBIOB; CALCIOB;
CHROBIOB; COBALT; COPPER; IRON; LEAD;
BAGNESIOB; BANSANESE; BETALS;
BOLTBDEBOB; NICKEL; PHOSPHORUS;
EOTASSIOB; SILICON; SILVER; SODIOB;
STBOHTIOB; TIN; TITANIUB; VANADIOB ;
ZIIC; BIOACCDBOLiTIOS; HEALTH
HAZARDS; OCCOPATIOSAL HAZARDS;
TONGOE; ZIRCONIUM: ELESESTS
REFERENCE
Teraolca, H.
1981
Archives of
Environaental Health
36{0); 155-165
Teraoka* H>
1981
Archives of
36(
OJ
o
-------
Silicon
7HHO-21-3
Si
AtH 28.086, HP 1410 C. BP 2600 C. It 1 » Hg at 1721 C
(CONTINUED)
TIS5DE
6736
Heart
6737
Intestine
6738
Kidney
EXPOSURE BOOTE
„!
ANALYTICAL
BETHOD
ES
_ _
ES
ES
HDBBER
OF CASES
a) 8
b) 2
c) 3
d) 1
e) 1
10
a) 8
b) 2
c) 3
d) 1
e) 1
BINGE
a) Hot given
b) 30-76 ppi
c) 43-82 ppi
d) Not applicable
e) Hot applicable
Dry »t
Not given
a) Not given
b) 33-64 ppi
c) 31-68 ppi
d) Mot applicable
e) Hot applicable
Dry »t
HE in
_________ _________
a) 18 +or- 6. 3 ppi
b) S3 ppi
c) 62 ppi
d) 37 ppi
e) 53 ppi
Dry wt
31 *or- 1i* ppi dry ¥t
a) 23 + or- 17 ppa
b) 48 ppi
c) 21 pp«
d) S3 ppi
e) 42 ppm
Dry wt
GENERAL INFORBATION
a) Horial healthy ien
b) Chroiiui plating workers
c) chroiate refining workers
d) Airplane painter
e) Stone nason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENA1
GLANDS: AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVES; LONGS;
LYBPH NODES; PJNCEEAS; SPLEEN;
STOBACR; THIBOID GLANDS; TKACREA;
ALOHINHH; BABIOH; CADBIDH; CALCIBH ;
CBROniDH; COBALT; COPPER; IRON; LEAD;
HAGNESID9; 9ANGANZSE; BETALS;
BOLIBDENHa; NICKEL; PHOSPHORUS;
POTASSIDD; SILICON; SILVER; SODIUB;
STEONIIOB: TIN; TITANIOB; VANADIHB;
ZINC; BIOACCDBDLAIION: HEALTH
RAZASDS; OCCUPATIONAL HAZARDS:
TCNGHE; ZIRCONIOB; ELEBENTS
Norial tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; IDRE»AL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LITER; LUNGS;
LYMPH NODES; PAHCKEAS; SPLEEN;
STOHACH: TBIROID GLANDS; TRACHEA;
ALDBINQB; BARIUB; CADHIUB; CALCIDB ;
CBROBIBB: COBALT: COPPER; ISOH; LEAD;
H1GNESIUB; BANGASESE; HETALS:
EOLYBDENDB; NICKEL; PHOSPHOIDS;
POTASSIOB; SILICON; SILVER; SODIDB;
STRONTIDH; TIN'. TITAKIDB; ?ANADIUH;
ZINC; BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUH: ELEHEItTS
a) Nornal healthy ien
b) Chroiiui plAting workers
c) chroiate refining workers
d) Airplane painter
e) stone lason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES: KIDNEYS; LITER; LUNGS;
IYBPH NODES; PANCREAS; SPLEEN;
STOHACR; THYROID GLANDS; TRACHEA;
1LUBINOB; BARIUB; CADBIUH; CALCHIB;
CRROBIUB; COBALT; COPPER; IRON; LEAD;
HAGNESIUB; BANGAHESE; BETA IS;
BOLYBDENDB; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON; SILTER; SODIUB;
STRONTIDH; TIN; TITA1IIUB; TANADIUS;
ZISC; BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIDB; ELEBENTS
(NEXT PAGE)
Teraoka, B.
1981
Archives of
E nvi con^ental He alt h
36 t»): 155-165
Teraoka, H.
1981
Archives of
EovicoDBental Health
i 155-165
Teraoka, H.
1981
Archives of
Environnental Health
:155-165
-------
Silicon
7(110-21-3
Si
At« 28.086,
6739
liver
SP 1110 C, BP 2600 C, VP 1 » Hq at 1720 C
(COHTIRUED)
67«0
Lung
6741
Lyiph
node
EXPOS UEE BOOTS
ANALYTICAL
METHOD
ES
ES
ES
RUBBER
OF OSES
a) 9
b) 2
c) 3
d) 1
e) 1
a) 12
b) 2
0 3
d) 1
e) 1
a) 3
b) 1
c) 3
d) 1
e) 1
BARGE
a) Hot given
b) 22-61 ppi
c) 46-230 ppi
d) Sot applicable
ej Hot applicable
Drr wt
a) Hot given
b) 450-630 pp»
c) 330-890 ppi
d) Hot applicable
e) Hot applicable
Or; lit
a) Hot given
b) Hot applicable
c) 790-4700 ppi
d) Hot applicable
e) Hot applicable
Dir it
,
HEAR
b) 42 ppi
c) 109 ppi
d) 46 ppi
e) 290 ppi
Dry wt
a) 390 *or- 280 ppi
b) 540 ppi
c) 845 ppi
d) 410 ppi
e) 9500 ppi
Dry wt
a) 7000 *or- 3000 ppi
b) 1800 ppi
c) 3230 ppi
d) 7100 ppi
e) 21000 ppi
Dry wt
GERERAL IHFORKATIOH
b) chroiiui plating workers
c) chroiate refiniig workers
d) Airplane painter
e) Stone lason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBEHAL
GLARDS; AOBTA; BORES; HEART;
IRTESTIHES; KIDHEIS; LIVER; LONGS;
LYHPH RODIS; PAHCBEAS; SPLBER;
STOBACH; THIEOID GLA8DS; TBACHEA;
ALUBISUB; BAKIOB; CADBIOB; CALCIOB;
CHBOHIUH; COBALT: COPPE1; IBOR; LEAD;
BAGRISIOH; HARGARESE; HETALS:
SOLTBOEHDH; NICKEL; PHOSPHORUS;
POT AS Sln«; SILICON; SILVER; SODIUB;
STEOHTIUB; TIH; TITAHIOB; VARADIUB ;
ZIKC; BIOACCOBDLATIOR; HEALTH
HAZARDS; OCCDPATIOHAL HAZARDS;
TONGDE; ZIECONIUB: ELEBENTS
a) Horial healthy ien
b) Chroiiui plating workers
c) Chroiate refining workers
d) Airplane painter
e) stone lason
Autopsies
Japan
JAPAR; ADULTS; AUTOPSIES; ADBEHAL
GLARDS; AOBTA; BORES; HEART;
INTESTINES; ICIDHETS; LITEB; LUNGS;
LIBPB ROD2S; PAHCBEAS; SPLEER;
STOBACH; THIEOID GLAHDS; TRACHEA;
ALOBINOB; BARIOB; C4DSIUB; CALCIDB;
CBPOBIDB; COBALT; COPPEE; IBOR; LEAD;
BAGNESIDB; HAR6AHESE; HETALS;
BOLTBDEHOH; NICKEL; PHOSPHORUS;
EOTAS5IDB; SILICOR; SILVEB; SODIOB;
STBOHTIUB; TIR; TITAHIUB; TARADIDH;
ZIRC; BIOACCDHULATIOR; HEALTH
HAZABbS; OCCDPATIOIAL BAZABDS;
TOHGDX; ZIBCOHIDH; ELEMENTS
a) Ronal healthy ien
b) chroiiui plating worker
c) chroiate refining workers
d) Airplane painter
e) Stone lason
Antopsies
Japan
JAFAR; ADDLTS; AUTOPSIES; ADBE1AL
GLARDS; AORTA; BORES; HEABT;
UTESTINES; KIDRETS; LITER; LUNGS;
LIBPH HODES; PAHCBBAS; SPLEER;
STOBACH; THIBOID GLARDS; TRACHEA;
ALOBIBUB; BARIOH; CADBIUB; C1LCIOB;
CBBOHIUH: COBALT; COPPEB; IRON; LEAD;
HAGRESIOB; BARGAIESE; HETALS;
BOLYBSERUH; NICKEL; PHOSPHORUS;
POTASSIUH; SILICOR; SILVER; SODIUM;
STBORTIUH; TIR; TITAHIUB; TARADIUB:
ZIRC; BIOACCtJHUHTION; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TORGUE; ZIBCORIUH; ELEHERTS
BEFEEESCE
1981
Archives of
Environmental Health
36(4): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
Teraoka, H.
1981
Archives of
36(4): 155-165
N3
OJ
(REXT PAGE)
-------
silicon
7440-21-3
Si
At» 28.086,
HP 1«10 C, BF 2600 C, VP 1 » Hg at 1724 C
(CONTINUED)
TISSUE
6742
Pancreas
6703
Spleen
6744
stoaach
t
t
ETPOSORE ROUTE
ANALYTICAL
HETHOD
ES
ES
ES
JOBBER
OF CASES
5
a) 9
b) 2
0 3
d) 1
e) 1
10
RANGE
Mot given
a) Mot given
b) 32-160 ppi
c) 46-100 ppa
d) Hot applicable
e) lot applicable
Dry wt
.
Not given
DEAN
33 *or- 23 ppa dry wt
a) 48 «or- 45 ppa
b) 96 ppa
c) 109 pp.
d) 130 pp»
e) 3900 ppi
Dry wt
31 +or- 14 ppM dry wt
GENERAL INFOBBATION
NorBal tissue
Autopsies
Japan
JAPAN: ADDLTS; AUTOPSIES; ADEENAL
GLANDS: AOBTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVES; LUNGS;
LYBPH NODES; PANCREAS; SPLIEN;
STOBJCB; TKTROID GLiBDS; TBACHEA;
ALCHINOH; BARIOB; CiDBIIJB; CILCIOB;
CHBOflltlB; COBALT; COPPKB; IKON; LEAD;
BJGNESIOB; BAHGANESE; HETALS;
B01IBDEROB; NICKEL; PROSPHOBOS;
POTtSSIDB; SILICOM; SILVER; SODinn;
STROHTIUH; TI»; TITANinH; VAMADIOll:
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCDPATIONAL HAZARDS;
TONGUE; ZIRCONItm; ZLEHENTS
a) Nor«al healthy aen
b) chroniua plating workers
c) ChroMate refining workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEIS; LIVER; LUNGS;
ITBPH NODES: PANCREAS; SPLEEN;
STOHACH; TBIBOID GLANDS; TRACHEA;
ALoniNun; BiRicin; CADBIOB; CALciun;
CHROBIOB; COBALT; COPPER; IRON; LEAD;
HAGNESIUB; HANGANESB; HBTALS;
HOLTBDENUn; NICKEL; PHOSPROBUS;
FCTASsion: SILICON; SIIVES; SODIUB:
S1RONTIUB; TIN; TITANIOH; VANADIUB;
ZINC; BIOACCOBOLATIOH; HEALTH
RAZABDS; OCCDPATIONAL HAZARDS;
TONGUE; ZIBCONIOH; ELEtlENTS
NorBal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVES; LUNGS;
LTBPH NODES; PANCREAS; SPLEEN;
STOHACH; THYROID GLANDS; TRACHEA;
ALUBINUB; BABIDB; CADBIUH; CALCIUB;
CHROniUB; COBALT; COPPER: IRON; LEAD;
BAGNESIDB; BANGANES2; HETALS;
BOLYBDENUH; NICKEL; PHOSPRCRDS;
POTASSIUB; SILICON: SILVER; SODIOH;
STBONTIDH; TIN; TITANIUB; VANADIUB;
ZINC; BIOACCnauLATION; HEALTH
HAZARDS; OCCDPATIOBAL RAZABDS;
TONGUE; ZIRCONIOH; ELEHENTS
(NEXT PAGE)
Teraoka, H.
1981
Archives of
Environaental Health
36(1):155-165
Teraoka, H.
1981
Archives of
Environaental Health
36(4):155-165
U)
Teraoka, H.
1981
Archives of
Environaental He<h
36(4):155-165
-------
Silicon
7440-21-3
Si
AtH 26.066, tit 1410 c, BP 2600 C, VF 1 a» Eg at 1724 C
(CONTINUED)
TISSUE
6745
Thyroid
gland
6746
Tongue
6747
Trachea
EXPOSURE JtOOTE
ANALYTICAL
I1ETHOD
SS
ES
SS
NOBEEB
OF CASES
II
2
2
BANGE
Not given
Hot given
Not given
16 »or- 5.0 ppi dry
»t
17 +or- 9.9 ppM dry
lit
25 +or- 11 ppa dry wt
GENERAL HFORBATION
BEFEREBCE
Normal tissue
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADBENAL
GLANDS; AOBTA; BOHES; HEART;
INTESTINES; KIDHETS; LIVES: LOSGS;
1IHPH NODES: PANCREAS; SPLEEN;
STOHACH; THtBOID GLANDS; TBACHEA;
ALDBISOB; BABI08; CADBIOH; CALCIUM;
CHROrtlUfl; COBALT; COPPEB; IBON; LEAD;
HAGNESIOH; HANGANESE; BETHIS;
ROLTBDENOH; NICKEL; PHOSPHOBUS:
POTASSIDB; SILICOII; SIL'IB; SODIOH;
STBOHTIO!!: IIN; TITANIon; VAHADIOB;
ZINC; BIOACCOBOLATION; HEALTH
HAZABDS; OCCOPATIONAL HAZABDS;
TONGOE; ZIBCONIOH; ELEBENTS
Nor»al tissue
Autopsies
Japan
JAPAN; JDOLTS; AOTOPSIES; ADBENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVEB; LONGS;
LYSPH NODES; PAHCBEAS; SPLEEN;
STOBACR; THtEOID GLANDS; TBSCHBA;
ALOBINUB; BABIOB; CADBIOH; CALCIBB;
CBEOHIOH; COBALT; COPPEB; IBON; LEAD;
BAGNESIOn; MANGANESE; BETALS;
BOLTBDEN08; NICKEL; PROSPHOBOS;
POTASSIOB; SILICON; SILVER; SODIOB;
STBONTIDB; TIN; TITANIOH; VANADIHB;
ZINC; EIOACCnHOLATIOS; BBALTH
HAZABDS; OCCUPATIONAL HAZABDS;
TONGUE; ZIKCONIOB; ELEBENTS
Norial tissue
Autopsies
Japan
JAPAN: ADOLTS; AUTOPSIES; ADBENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNETS; LI7EB; LUNGS:
LtBPH NODES; PANCREAS; SPLEEN;
STOBACR: THTBOID GLANDS; TRACHEA;
ALtmiNUB; BJRIOfl; CADBIOB; CALCIUB:
CBBOBIUB; COBALT; COPPER; IRON; LEAD;
BAGNESIOB; MANGANESE; BETALS;
BOLTBDENUB; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON; SILVEF; SODIOB;
STBONTIOB; TIN; TITANIDB; VANADIUB;
ZINC; BIOACCONnLATIOIl; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOBGIJE; ZIRCONIUR; ILSBEHTS
Tecaoka. R.
1981
Archives of
Environmental Health
36(«):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
Teraoka, R.
1961
Archives of
Environmental Bealth
36(4):155-165
-------
Silver
7100-22-11
»9
AtW 107.868, HP 960.5 C, BP 2000 c. VP 1 » Kg at 1310 C, 10 " Bg at 1540 C
TISSOE
67 «8
Adrenal
gland
67K9
Aorta
6750
Bone
6751
Bone
EXPOSOSE ROUTE
ANA1YTICA1
BETHOD
ES
ES
ES
Nt
KOflBEI
07 CASES
7
7
5
7
EAKGE
Not given
Not given
Not giv«a
<0. 003-0. 025 ppn
BEAN
<0.03 ppm dry wt
<0.03 ppm dry wt
<0.3 ppm dry wt
Not aiven
GENERAL XNFORBATION
Normal tissue
Autopsies
Japan
JAPAN; ADOLTS; AOTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART:
IHTESTISBS; KIDNEYS; LIVER; LONGS;
LYBPR NODES; PANCREAS; SPLEEN;
S10BACH; THYROID GLANDS; TRACHEA;
AlOHINOM; BAEIOB; CADBIUB; CALCIOB;
CRROBIUB; COBALT; COPPER; IRON; LEAD;
HAG1IESIUB; HANGANESE; BETALS;
BOLYBDENOB; NICKEL: PHOSPHOEUS;
POTASSIOB; SILICON; SILVER; SODIOB ;
S1RONTIOB; TIN; TITABIOB; VANADIOB;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUH; ELEBENTS
Normal tissue
Autopsies
Japan
JAPAN; ADOLTS; AOTOPSIES; ADRENAL
GLJSDS; AORTA; BONES; HEART:
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
ALOBINOH: BARIOB; CADBIOB; CALCIUB;
CBSOSIUH; COBALT; COPPER; IBOS; LEAD;
BAGNESIOB; BANGANESE; BETALS;
BOLYBDENOB; NICKEL; PHOSPHORUS;
POTASSIOB; SILICON: SILVER; SODIOB;
STRONTIOfl; TIN; TITANIOB; VANADIOB;
ZISC; BIOACCOfiULATIOH; HEALTH
HAZARDS; OCCOPATIONAL HAZARDS;
TONGUE; ZIRCCNIOB; ELEBENTS
Noraal tissue
Autopsies
Japan
JAPAN; ADOLTS: AOTOPSIES; ADRE8AL
GLANDS; AORTA; BONES; HEART:
INTESTINES; KIDNEYS; LIVER; LUNGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOHACH; THYROID GLANDS; TRACHEA;
ALBHI1TOH; BABIOH; CADHIUB; CALCIOB;
CBROBIOH; COBALT; COPPER; IRON; LEAD;
BAGNESIOB; BANGANESE; BETALS;
BOLYBDEHUB; NICKEL; PHOSPHORUS;
POTASSIOH; SILICON; SILVER; SODIOB;
S1R08THJB; TIB; TITA8IOS-, VA8ADIOH;
ZINC; BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGUE; ZIRCONIOB; ELEBENTS
Autopsies, feiur
45-75 yr old factory workers, Sweden
ASTIROBY; ARSE»IC; CADRIOB ; COPPER;
LEAD; BERCORY; SELENIOB; SILVER; TIN;
ZINC; BIOACCOBOLATION; INDUSTRIAL
ATBOSPHERES; INDOSTBIAL PLANTS;
POPOLATION EXPOSURE; SBELTEBS; BONES;
JESOR; COBPARATHE EVALIHTIOIIS;
SOEDEN; AUTOPSIES; OCCUPATIONAL
HAZARDS; BETALS
_
REFE8ENCE
Teraoka, H.
1981
Archives of
36(«l : 155-165
Teraoka, B,
1981
Archives of
Environmental Health
36(1) :155-165
Teraoka. R.
1981
Archives of
Environmental Health
36(1): 155-165
Lindh, 0.
Brune, D.
Hordberg, G.
Sester, P.-o.
1980
Science of the Total
Environment 16:109-116
(NEXT PAGE)
-------
Silver
7440-22-4
>9
AtR 107.868,
HP 960.5 C, BP 2000 C, VP 1 mm Hg at 1310 C, 10 BB Hg at 1540 C
(COHTIHUED)
TISSUE
6752
Hair
6753
Hair
6754
.Hair
6755
Heart
EXFOSORE BOOTS
ANALYTICAL
HETHOD
Ik
HA
ni
BS
I OK BEE
OF CASES
56
21 saaples
. _ -
a) 8
b) 2
O 3
d) 1
e) 1
BADGE
46.5I10(E-6)-2643XIO(E-6)
g/cu CM
180-1450 ng/g
a) 0.07-8.2 ppB
b) 9.48-2.93 ppB
c) 0.14—2.85 ppB
a) Mot given
b) <0. 03-0. 04 pp»
c) <0. 03-0. 09 ppl
d) Hot applicable
e) Hot applicable
Dry *t
HEAH
99.45I10(E-6) g/ca c»
Not given
a) 0.87 +or- 1. 1 ppn
b) 1.0 +or- 0.73 ppa
c) 1 . 25 +or— 0. 9 ppo
a) <0*03 ppB
b) lot given
c) lot given
d) <0.03
e) <0.03
Dry «t
GEHEBAL IHFORBATIOI
3 cm segments of single hairs
Data froB 4 persons, others belov
detection liiits
IRIDIDB; HAIB; FOREISIC BEDICIHE;
BE1SOBEBEHT BET BODS; ARTIHOHT;
ABSEIIC; EBOUIE; COPPED; GOLD;
LiHTHSHOn; HAIGAHESE; BEBCORI;
HETAIS; SELEIIOH; SIUEBj SODIOH;
STROHTinn; ZIHC; IIDOSTEIAL
ATHOSPHERES
Range of leans, estimated froi graph
Aswan, £1 Kharga, Assiut* Cairo, and
Alexandria , Egypt
EGYPT; HAIR: HAILS; AHTIBOBT;
CADHIOH; CES1QH; CHEOHI0H; COBALT;
I BOH; HAIGAHESE; HETALS; BOLtBDEKOB;
SCAHDHJB; SELEIIOS; SILTEB ; TOHOSTBH;
ZINC; DBIHKIIG >ATEB; POPOL1TIOH
IIPOSOBE; SOILS; ORBAH AREAS
.
a) 12 c> length, 91 saiples
b) Root section, 18 samples
sa>p es
Hetropolitan Bombay , India
IHDIA; ADOLESCEITS; ADULTS; HAIB;
AHTinOiy; ABSZHIC; BROHIHE; CJDKIOB;
CELORIHE; CHEOfllOn; COBALT; COPPER;
GOLD; IODIIE; IROH; LARTHAHDH;
KAHGAIESE; POTASSIDB; SCAHDIOH;
SELEIIng; SILVER; SODICIB; 7IIC; AIR
IOLLOTIOH; BIOACCDKDLATION ; FOSSIL
IOELED POHEB PLAITS; IHDDSTBIAL
AKEAS; IIDOSTBIAL ATHOSPHERES;
IIDOSTBIAL EBISSIOHS; INDUSTRIAL
FOLLOTIOH; POP0LATIOH EXPOSDBE; DRBAH
ABEAS; IHDHSTBIAL CHEHICALS
b) ChroniuB plating vorkers
c) Chronate refining vorkers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JAFAH; ADULTS; AUTOPSIES; ADBEIAL
GLAIDS; AOBTA; BOIES; HEART;
IITESTIIES; KIDIEIS; LIVEB; LDHGS;
LTBPH IODES; PA»CBEAS; SPLEES:
STOBACH; THIBOID CLAUDS; TBACRE1;
ALOBHOB; BARIOB; CADBIDB; CiLCIHB ;
CHBOBIDB; COBALT; COFFEE; I10H; LEAD;
BAGIESIOB; BAIGAIESE; BETA IS;
BOLTBDEHUB; SICK EL; PBOSPHOBOS;
POTASSIUB; SILICOH; SILVER; SODIOB ;
S1BOHTIOB: Til; TIT1HIOB; V1HADIUB;
ZIHC; BIOACCOBOLATIOH; HEALTB
HAZARDS; OCCOPATIOH1L BAZABDS;
TOHGOE; ZIRCOHIOB: ELEREITS
BEFEREHCE
Dybczynski, R,
Boboli, 1C.
1976
Journal of
Radioanalytical
chenistry 31:267-289
Kasperek, K.
lyengar, G. V.
Feinendegen« L.E.
Hashish, S.
aahfouz, B.
19B2
Bhat, K.R.
Arunachal B, J.
Sangadhar n, S.
1982
Science o the Total
Environne t 22:169-178
T e ra ok a , H .
1981
Archives of
36(4) : 155-165
N3
10
(BEtl PACE)
-------
Silver
7440-22-4
At* 107.868, BP 960.5 C, BP 2000 C, VP 1 •• Bg at 1310 C. 10 •• Hg at 1540 C
(COHTHUED)
TISSUE
6756
Intestine
6757
Kidney
6758
User
EXPOSURE ROUTE
ANALYTICAL
BETHOD
IS
ES
IS
JOBBER
OF CASES
10
a) 8
b) 2
c| 3
4) 1
e) 1
a) 9
b) 2
c) 3
1) 1
e) 1
RANGE
Hot given
a) Vat given
b) 0.01-0.05 ppi
c) 0.04-0.09 ppi
d) Nat applicable
e) Hat applicable
Dry (ft
a) Hot given
b) 0.06-0.13 ppi
c) 0.06-0.10 ppi
d) Not applicable
e) Hat applicable
Dry wt
(HUT
BEAN
0.06 +or- 0.03 ppa
dry wt
-
a) <0.03 ppi
b) 0.04 ppi
c) 0.06 ppi
d) 0. 13 ppi
e) <0.03 ppl
Dry «t
a) 0. 15 *or- 0.39 ppm
b) .09 ppi
c) .08 ppi
d) 0.06 ppi
e) 0.03 ppi
Dry wt
PAGE)
GENERAL IIFOBBATION
Norial tissae
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
CLAUDS; AOBTA; BONES; HEART;
INTESTINES; KID NETS ; LIVER; LUNGS;
ITBPH NODES; PANCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TBACHEA;
ALOBIHOB; BARIOfl; CADHIOB; CALCItM;
CBBOniOK; COBALT; COPPER; IRON; LEAD;
HAGHESIOH; BANGABESE: HETALS;
BOLtBDEHUB; NICKEL; PHOSPHORDS;
FOTASSID!); SILICON; SILVER; SODIOB;
STROSTIOB; TIH; TIT A NI OB; VANADIUB ;
ZIHC; BIOACCOBnLATIOR; HEALTH
HAZARDS; OCCUPATIOBtL BMIBDS;
TOHGDE; ZIRCONIOB; ELEHENTS
a) Honal healthy ien
b) chroiim plating nockers
c) chroiate refining workers
d) Airplane painter
e) stone lason
Aotopsies
Japan
JAPAN; ADULTS; AOTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDHET5 ; LIVES; LONGS;
1I8PH NODES; PANCBEAS; SPLEEN;
STOKACH; THYROID GLANDS; TRACHEA;
ALCBINOII; BARIOI!; CADBIUfl; CALCItJB ;
CHROaiUB; COBALT: COPPER: IRON; LEAD:
nAGNESIOH; 8AHGANESE; KETALS;
nOLYBDENUfl; NICKEL; PHOSPHOROS;
EOTlSSlnH: SILICON; SILVER; SODKJH;
STPONTIOn; TIN; TITAHIOH; VANADIOK;
ZINC; BIOACCUHULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIQH; ELEBENTS
a) No rial healthy ten
b) chroiiui plating workers
c) Chroiate refining workers
d) Airplane painter
e) Stone lason
Aatopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BOHES; HEART;
INTESTINES; KIDNETS; LIVER; LONGS;
LTHPH NODES: PANCBEAS; SPLEEN;
STOBACH; THIROID GLANDS: TRACHEA;
ALtmiBUB; BARIOB; CADHIHII; CALCIUB ;
CBBOBIOH; COBALT; COPPER; IRON; LIAD;
BAGHESIUB; BANGANESE; KETALS;
BOLIBDENUH; NICKEL; PHOSPHOROS;
POTASSinil; SILICON: SILVER; SODIUfl;
STROSTIOS; TIN; TITAHIOn; VANADIUH:
ZIHC; BIOACCOHDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
1 TOBGOE; ZIRCONIOR; ELEBENTS
1
REFERENCE
T-eraoka, H.
1981
Archives of
36(«):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
Teraoka , H.
1981
Archives of
Environmental Health
36(»):155-165
K3
-------
Silver
7«»0-22-
b) <0.06 ppm
c) <0.06 ppm
d) <0.06 ppi
e) <0.06 ppi
Dry wt
GENERAL IHFORBATION
Category 2 as proposed by
International workshop on Monitoring
Environmental Materials and Specimen
Banking (noo-pollutant trace element
f '
Autopsies, Baltimore, HD,
(linneapolis, UN, and Seattle, »A
MARYLAND; gINNESOTA; HASHINGTON;
AOTOPSIES; LITER; KE1SOREIIENT
HETHODS; ALOillNOH; ANTlnONI; ARSENIC;
EARIOH; CADSIOHj CHROBlafl; COBALT:
COPPER! FLUORINE; IEON; LEAD;
MANGANESE; HERCOEI; HOLTBDENOR;
NICKEL: RDBIDIOII; SELEHIOB; SILVER;
STROHTIDB; TBALLIOH; TIM; VAHADIOH;
ZINC; POPULATION EXPOSORE
a) Normal healthy men
b) Chromium plating workers
c) chromate refining workers
d) Airplane paintec
e) stone mason
Autopsies
•Japan
JAPAS; ADDLTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LIHPH NODES; PANCREAS; SPLEEN;
STOHACH; THIEOID GLANDS; TRACHEA;
AioaiNon; BABina; CADBIOB; CALCIOS;
CBRoninn; COBALT; COPPER; IRON; LEAD;
n AGNES ion; MANGANESE; METALS;
NOLTBDENOK; NICKEL; PHOSPHORDS;
POTASSI09; SILICON; SILVER; SODIHH;
STROBTIOB; TIN; TITANIOB; VAKADIO!!;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZlttCONIUK; SLEflENTS
a) Normal healthy men
b) Chroniun plating worker
c) Chromate refining workers
d} Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOHACH; THIROID GLANDS; TRACHEA;
AUJKINnn; BARIUH; CADSIan; CALCIOB;
CBBOHIUH: COBALT; COPPER; IRON; LEAD;
HAGNBSIUH; 1ANGANESE; HETALS;
BOLTBDENUH; NICKEL; PHOSPHOROS;
EOTASSIUH; SILICON; SILVER; SODIUB;
STRONTIOH; TIN: TITANIOH; VANAOIUH;
ZINC; BIOACCDHDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUH; ELE BESTS
REFERENCE
Harrison, S.H.
Zeisler, B.
Vise, S.A.
1981
WP4 600 /SI —81 ~02 5 6
pp.
Tcraoka, H.
1981
Archives of
36(«) :155-165
Teraoka, 8.
1981
Archives of
Environmental Health
36(4): 155-165
_
(NEIT PAGE)
u>
00
-------
Silrer
TmO-22-1
«?
AtW 107.868, DP 960.5 C, BP 2000 C, VP 1 mm Hg at 1310 C, 10 » Hg at 151)0 C
(CONTINUED)
TISSUE
6762
Nail
6763
Pancreas
67 6«
Spleen
EXPOSURE ROUTE
ANALYTICAL
BETHOD
Hi
ES
ES
NUMBER
OF CASES
19 samples
5
a) 9
b) 2
c) 3
d) 1
e) 1
BAHGE
350-850 ng/g
-
Not given
a) Hot given
b) <0.03-<0.07 ppm
c) <0.03-<0.03 ppm
d) Hot applicable
e) Not applicable
Dry vt
Not given
<0.03 pp« dry »t
a) <0,03 pp«
b) <0.05 ppm
c) <0.03 ppm
d) <0.03 ppm
e) <0.03 ppa
Dcy wt
GENERAL INDORSATION
Range of means, estimated from graph
Asvan, El Kharga, Assiut, Cairo, and
Alexandria, Egypt
EGYPT; HAIR; SAILS; ANTISONY;
CADBIUfl! CESIOB; CHROBIUB; COBALT;
IRON; MANGANESE; HETALS; KOLYBDENUM;
SCUKDICll; SELEmtJS; SIL7E8; TDSGSTSN;
ZINC; DEIHKING SATES: POPOLATION
EXPOSDSE; SOILS; DBBAN AREAS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
G1HHOS; AOSTA; BOHES; HEART;
INTESTINES; KIDKETS: LIVES: LUNSS;
LYBPH NODES; PANCGEAS; SPLIEN;
STOBACH; THYROID GLANDS; TRACHEA;
AinniNUB; BARius; cAoaiuii; CALCIUB;
CHEOBIUB; COBALT; COPPER; IBON; LEAD;
BASNESIDB; BAKGANESE; HETALS;
HfllYBDESUB; NICKEL; PHOSPHOBOS;
POTASSIUB; SILICON; SILVER; SODItJB;
STRONTIOB; TIN; TITANIUB; VANADIRB;
ZINC; BIOACCUBOLATION; HEALTH
HtZABDS; OCCOPATIOSAL HAZABDS;-
TONGUE; ZIRCONIUB; ELEBENTS
a) Nornal healthy men
b) chromium plating workers
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS! LIVER; LUNGS;
LYBPR NODES; PANCREAS; SPLEEN;
STOMACH; THYROID GLANDS; TRACHEA;
ALUBINUB; BAEI08; CIDBIUH; CllCIOB;
CBBOBIDB; COBALT: COPPER: IRON; LEAD;
BAGNESIU1; BASGANESE; BETALS;
BOLIBDENUB; NICKEL; PHOSPHORUS;
POTASSIOB; SILICON; SILVER: SODIUB;
STRONTIOH; TI»; TirANIUB; VABADIUB;
ZIBC; 3IOACCOBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONSUE; ZIRCONIUfl; SLEHENTS
BEFESENCE
Kasperek, K.
I yen gar, G.v.
Feinendegen, L.E.
Hashish, 5.
Nahfouz, B.
1982
Science of the Total
Environment 22:1«9-168
Teraoka, H.
1981
Archives of
Environmental
36(») :155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(0) : 155-165
(NEXT PAGE)
-------
Silver
T100-22-4
Ag
ltd 107.868, HP 960.5 C, BP 2000 C, TP 1 •• Hg at 1310 C, 10 » Hg at 1510 C
(COKTIRUED)
TISSUE
6765
StORach
6766
Thyroid
gland
6767
Tongue
E IPOS ODE ROUTE
ANALYTICAL
nETBOD
ES
IS
ts
SOB BEE
OF CASES
10
4
2
RABSE
Dot given
Mot given
lot given
(IE IT
HEAD
0.06 *or- 0.03 ppB
dry lit
<0.03 pp» dry ut
.
<0.03 pp« dry tit
PAGE)
GENERAL IRFORHATIOR
Horaal tissue
Autopsies '
Japan
JAP**; ADOITS; AUTOPSIES; ADREffAL
GLAHDS; AOBTA; BOXES; HEARI;
IHTESTIHESJ ICIDBEIS; LITER; LOMSS;
ITBPB NODES; PAHCREAS; SPLEEK;
STOBACH; THYROID GLABDS; TBICHEA;
ALOnlBOfl; BARIOH; CADBjnn; CALCIOH;
CBEOHID8; COBALT; COPPER; IROH; LEAD;
BAGSESIOB; HAHSAHESE; (IETALS;
BOLIBDEBOa; NICKEL; PnoSPHOBDS;
POTASSIDH; SILICON; SILVER ; SO Din 9;
STROBTIOH; TIN; TITAHIOB; VAMADIDB;
ZI«C; BIOACCOnOIATIOll; HEALTH
HAZARDS; OCCOPATIOBAL HAZARDS;
TOBGOE; ZIECOBIOB; ILEBEBTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADREXAL
GLABDS; AOETA: BORES; HEART;
IITESTIRES; KIDBEKS; LITE!; LURES;
LIBPH RODES; PARCREAS; SPLEER;
STOBACH; TRIROID GLABDS; TRACHEA;
ALDBIRDH; BARIOH; CADBHH1; CALCIUB :
CHBOBIOB; COBALT; COPPER; IBOB; LEAD;
BAGRESIDH; BABGANESE: HETALS;
DOLTBDEROH; RICKEL; PHOSPHORUS;
POTASSIDB; SILICON; SILVER; SODIOH ;
STRORTIDH; TIR; TITARIOB; VANADIOK;
ZIRC; BIOACCDBOLATIOR; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TORGUE; ZIHCOBIOn; ELEgERTS
Rorial tis&ae
Autopsies
Japan
JAPAR; ADULTS; AUTOPSIES; ADRERAL
GLAJDS; AORTA; BORES; HEAHT;
IRTESTIRES; KIDRETS; LITER: LUKGS;
LTBPH RODES; PARCREAS; SPLEER;
STOBACH; T8I80ID GLARDS; TRACHEA;
AtUHIROn; BABIOB; CADBIUH; CALCIOB;
CE50BIOB; COBALT; COPPER; IROR; LEAD;
(I1SHISIOB; URSAVESE; Bill IS;
BOLIBDEBOB; NICKEL; PHOSPHORUS;
POTASSIUfl; SILICON: SILTER; SODIUH;
STRORTIOH; Tin; TITABIOB: TARADIUB;
ZIRC; BIOACCOBOLATIOB; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS:
TOBGOE: ZIRCORIDR: ELEHERTS
REFERENCE
Teraoka, H.
1981
Archives of
EnvironaentaL Health
36 («): 155-165
Teraoka, H.
1931
Archives of
36(»): 155-165
Teracka, H.
1981
Archives of
Environmental Health
36 («) 1155-165
to
*-
O
-------
Silver
7«»0-22-»
>9
Atw 107.868, HP 960.5 C, BP 2000 c, TP 1 •• Hg at 1310 c, 10 •> fig at 1540 C
(CONTINUED)
TISSUE
6768
Trachea
.
EIPOSORE BOOTE
ANALYTICAL
RETHOD
ES
IOHBEB
or CASES
2
BINGE
Not given
MEAN
<0.03 +or- 0.01 ppm
dry »t
GEIEBAL INFORHATION
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AOTOPSIES; ADREIAL
GLANDS; AORTA; BONES: HEART;
INTESTINES; KIDNEYS: LITER; LDNGS;
LYBPH HOSES; PKNCBEAS; SPLEEN;
STOHACH; THOOID GLANDS; TRACHEA;
ALOHIHUH; BAHinH; CADBIOB; CALCIOH;
CBBOMIOH; COBALT; COPPEE; IIOH; LEAD;
HAGHESIDH; HAHGAVESE; METALS;
SOLTBDEBtln; SICKEL; PHOSPHOHDS;
FOTASSIOn; SILICON; SILTED; SODIOH;
STBOHTIDII; TIN; TIT A HI OB; TAHADI08;
ZI»C; BIOACCOBBLATI08; HEALTH
BIZABDS; OCCnPATIOBil HilABDS;
TOUGH E; ZIRCOSIOII; ELERE1CTS
BEFEBEKCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
Scdiui
7HHO-23-5
Da
At» 22.98977, BP 97.82 C, EP 881.1 C, TP 1 •• Kg at 110 c, 10 •• Hg at 546 C
TISSUE
6769
Adrenal
gland
6770
Aorta
EXPOSURE BODTE
AHALITICAL
HETHOD
ES
ES
HIMBER
OF CASES
7
7
RANGE
Not given
Hot given
BEAN
5200 *or- IttOO ppm
dry «t
8700 »or- 2800 ppi
dry »t
GENERAL INFOFBATION
Noraal tissqe
Japan
TOKGOE; ZIRCONIDB; ELEMENTS; JAPAN;
A COLTS; AUTOPSIES; ADRENAL GLANDS;
AOBTA; BONES; HEART; INTESTINES;
KIDNEYS; LITER; LONGS; LTBPH NODES;
SPLEEN; PANCBEAS; STOBACH; THYROID
GLANDS; TBACflEA; ALOBINHS: BARIUM;
CADHIUB; CALCIOM; CBRORIUH; COBALT;
CCPPEE; IRON; LEAD: DAGBESIDH;
HASGANESE; METALS; MOLYBDENUM;
NICKEL; PHOSPHORUS; POTASSIOB;
SILICON; SILTEB; SODIUM; STROSTIOH;
TIN; TITADlaa; ?l«ADIOB; ZINC;
BIOACCBBDLATION; BEALTH HAZARDS;
CCCOPATIONAL BAZAEDS
Noraal tissue
Japan
TONGUE; 2IRCONI1M; ELEMENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BOHES; HEART; INTESTINES;
KIDNEYS; LIVER; LONGS; LTBPR NODES;
SPLEEN; PANCREAS; STOMACH; THYROID
GLANDS; TPACHEA; 1LOHINDH; BARIUM;
CADMIUM; CALCIUM; CHROHIOB; COBALT;
CCFPER; IRON; LEAD; BAGNESIUB;
BANGANESE; RETALS; MOLYBDENUM;
NICKEL; PHOSPHOBOS: TOTASSIOR;
SILICON; SILTER; SODIDfl; STROSTIUB;
TIN; TITANIDB; TANADIUB; ZINC;
BIOACCUBHLATION; BEALTH HAZARDS;
CCCOPATIONAL HAZARDS
(NEXT PAGE)
REFERENCE
Teraoka* H.
1981
Archives of
Environmental Health
36(11:155-165
Teraofca, H.
1981
Archives of
Environmental Health
36(»):155-165
-------
Sodiui
7440-23-5
Ha
At« 22.98977, nP 97.82 C. BP 881.0 C, VP 1 » Hg at 440 C, 10 11 Hg at 546 C
(CONTINUED)
TISSUE
6771
Bone
6772
Hair
6773
Heart
EXPOSURE ROUTE
ANALYTICAL
RETROD
ES
»A
ES
HUSBER
OF CASES
5
8
RANGE
Hot given
a) 24-530 pp«
b) 39-304 PP«
c) 22-320 pp»
Hot given
HE4K
8100 +or- 2100 ppa
dry «t
a) 96 »or- 75 ppm
b) 107 «or- 64 ppu
c) 90 *or- 74 pp»
5600 +or- 1300 ppn
dry »t
GENERAL MFOEHHTIOK
Japan
T05GOE; ZIECOXIafl; E1EHENT5; JAP1N;
iDOLTS; JOTOPSIES; »D8ES»I GLANDS;
»OET»; BOHES; HE»ET; IHTESTIHES;
KIDNEYS; LIVEB; LOHGS; LYUPB HODES;
SPLEEN; PANCBEJS; STOMACH; THTBOID
GLANDS; TEACBEH; ALnHlBnH; BABIDS;
cionion; CALCIDH: CHBOHIO«; COBALT;
COPPER; IBON; LEAD: BAGNESII1B;
BAHGANESE; BETALS; BOLTBDEKHH;
NICKEL; PHOSPHOBOS; POTlSSIUn;
SIIICOH; SILVEB; SODIOH; SI80BTIOI1:
TIN; TITINIOM: TAMDlnH; ZINC;
BIOACCOnOLJTIOS; HEALTH HAZARDS;
OCCUPATIONAL BAZJBDS
a) 12 CB length, 104 samples
b) Root section, IB samples
c) Distal section, 19 saiples
Metropolitan Boaba;, India
ISDIA; ADOLESCENTS; ADULTS; HAIR;
ANTinONT; ABSENIC; BBOHINE; CADKIDH;
CBLOBIBE; CBBOHIOB; COBiLT; COPPEE;
SOLD; IODINE; IRON; LkHTHOOH;
H1NGANESE; POTASSIOfl; SCAN 01OB;
SELENIUH; SILVEB: SODIOH; ZINC; AIE
EOLLDTION; BIOACCDHULATIOH; FOSSIL
FUELED POKES PLAHTS; INDUSTRIAL
ABEAS; IDDOSTRIAl iTBOSPHEBES;
INDUSTRIAL EMISSIONS; INDUSTRIAL
POLLUTION; POPULATION EXPOSURE; DKSAN
ABEAS; INDUSTBIAL CHEIIICALS
Normal tissue
Japan
TONGUE; ZIRCONIUB; ELEBENTS; JAPAN;
ADULTS; AUTOPSIES; ADBEHAL GLANDS;
AORTA; BONES; HEART; INTESTINES;
KIDNETS; LIVEB; LUBGS; LYNCH NODES;
SPLEEN; PANCREAS; STOBACH; THYBOID
GLAHDS; TRACHEA; ALDIUNOH; BARIUH;
CADHIOtl; CALCIUH; CHEOBIUa; COBALT;
COPPER; IRON; LEAD; HAGNESIUH;
BANGANESE; BETALS; BOLIBDENUB;
NICKEL; PHOSPHORUS; POTASSIUB;
SILICON; SILVER; SODIUB; STBOBTIUB;
TIN; TITANIDH; TANAOIUB; ZINC;
EIOACCOHULATION; H2ALTB HAZARDS;
OCrnPHTIONAL HAZARDS
Teraoka. H.
1981
Archives at
Environmental Health
3«(«( : 155-165
Bhat, K.R.
Arunachalaa, J.
Tegnasubraaanian, 5.
Gangadharan, S.
1982
Science of the Total
Environient 22:169-178
N3
•P>
N>
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
(NEIT PAGE)
-------
Scdiui
7440-23-5
Ha
At« 22.98977, HP 97.82 C. EP 881.4 C, TP 1 •• Hq at DUO C, 10 ma Hg at 546 C
(CONTINUED)
TISSUE
6774
Intestine
6775
Kianey
6776
liver
EIPOSURE ROUTE
ANALYTICAL
MET BOD
ES
IS
ES
N09BER
OF CASES
10
a
9
BADGE
.
Hot given
Hot given
Hot given
(BEIT
HEAD
1300 tot- 1200 ppa
dry ¥t
10000 -tor- 3400 ppM
dry vt
5900 -for- 1900 pp«
dry »t
PAGE)
GENERAL INFORMATION
Horm&l tissue
Japan
TONGUE: ZIRCONIUM; ELEMENTS; JAPAN;
AD01TS; AOTOPSIES; ADBENAL GLANDS;
AOBTA; BONES: BEABT; IBTESIINES ;
KIDNEYS; LITER; LONGS; LYHPH NODES;
SPLEEN; PAHCEEAS; STOSACH; THYROID
GLANDS; TRACHEA; JLOBISOrt; BARIDK;
CAOniOII; CALCIDK; CHEOfllUn; COBALT;
COPPER; IBON; LEAD; BAGNESIOB;
KANGANES!; METALS; MOLIBDENDH;
NICKEL; PHOSPHORUS; POTASSIDM;
SILICON; SILTEB; SODIUB; STHONTIOH;
TIN; TITANIUM; tiNADIOB; ZINC;
BIOACCDHDLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
Noraal tissue
Japan
TONGUE; ZIRCOVIDM; ELEHENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEART; INTESTINES;
KIDNEYS; LITER; LUNGS; LYHPH NODES;
SPLEEN; PANCBEAS; STOMACH; THYROID
GLANDS; TRACHEA; ALUMINUM; BARIUM;
CAMIUM; CALCIUM; CHROHIUH; COBALT;
CCPPER; IBON; LEAD; MAGNESIUM;
MANGANESE; METALS: MOLYBDENUM;
NICKEL; PH05PH060S; POTASSIUM;
SILICON; SILVER; SODIU8; SIBONTIUS;
TIN; TITANIUM; VANADIUM; ZINC;
BIOACCUMULATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
Noraal tissqe
Japan
TONGUE: ZIRCONIUM; ELEMENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AOETA; BOSIS; HE AST ; IHTESDIHES;
KIDNEYS; LITER; LUNGS; LYHPH NODES;
SPLEEN; PANCREAS; STOHACH; THYROID
GLANDS; TBACHEA; ALUMINUM; BARIUM;
CADMIUM; CALCIUM; CHBOMIUM; COBALT;
COPPEB; IBON; LEAD; MAGNESIUM;
MANGANESE; METALS; MOLYBDENUM:
NICKEL; EHOSPHOBDS; POTASSIUM;
SILICON; SILTER; SODIUM; STRONTIUM;
TIN: TITABIOM; TASADIUM; ZINC:
BIOACCUHDLATION; HEALTH HAZABDS;
OCCUPATIONAL HAZARDS
BEFEBENCE
Tecaoka, H.
1981
Archives of
36(4): 155-165
Teraoka, H.
1981
Archives of
36(1): 155-165
Teraoka, H.
1981
Archives of
G nvi ronaental He alt b
36 (U): 155-165
N)
-------
Sodiai
7II40-23-5
da
AtB 22.98977, BP 97.82 C, BP 891.4 C, VP 1 » Hg at 440 C, 10 •• Hg at 546 C
(CONTINUED)
TISSUE
6777
lung
6778
Lyvph
node
6779
Pancreas
EXPOSURE BODTE
ANALYTICAL
BETHOD
ES
BS
IS
NUHBER
OF CASES
12
3
5
BANGS
Not given
-
Mot given
Not given
HEAN
11000 -for- 2700 ppa
dry wt
6200 +or- 2100 pp»
dry wt
7100 «or- 2900 ppi
dry vt
GENEBAL INFORHATION
Normal tissue
Japan
TOSGOE; ZIBCOHiaH; ELEKEITS; JiPlS ;
ADULTS; JOTOPSIES; 1DBEBAL GLAKDS;
AOBTA; BOHES: HE11T; I8TESTI1ES;
KIDNEYS; LIVER; LONGS; LTBPH MODES;
SPLEEN; PJKCEEiS; STOHACH; THTEOID
GLANDS; TBACHEA; 1LDBIBOH; BABIDfl;
CiDHIOB; CALCIDH; CHBOfllOK; COBALT;
COPPEB; IBOB; LEAD; 9AGNZSIOR;
HANGANESE; HETALS; HOLTBDENOH;
NICKEL; PHOSPHORUS; POTASSIDB;
SILICON; SILTED; SODIDH; SlBONTItM;
TIN; TITARIDR; T1NADIDH; ZINC;
BIOACCOHOLATION; HEALTH HAZABDS;
OCCDPATIONAL HAZIBDS
Noraal tissae
Japan
TOHGOE; ZIBCOBIOB; ELEHENTS; JAPAN;
ADULTS; AOTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEABT; INTESTINES;
KIDNEYS; LIYEB; LONGS; LTHPH NODES;
SPLEEN; PAICBEAS; STOHACH; THTBOID
GLANDS; TRACHEA; ALOnlNOH; BARID!);
CADHIUB; CALCIOH; CHROHI0H; COBALT;
COPPEB; IRON; LEAD; HAGSESIOB;
9ANGANESE; IETALS; HOLTBDENDH;
NICKEL; PHOSPHORDS; POTASSIOB;
SILICON; SILTED; SODIOH; STRONTIDH;
TIN; TITANIDH; TINADIDD; ZINC;
BIOACCUHDLATION; HEALTH HAZARDS;
OCCVPATIONAL HAZABDS
No»al tissue
Japan
TOKGOE; ZIRCOBIUB; ELSIENTS; JAPAN;
ADULTS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BONES; HEIR; INTESTINES;
KIDNEIS; LITER; LUNGS; LTRPR NODES;
SPLEEN; PANCREAS: STOHACH; THTBOID
GLANDS; TRACHEA; ALUHINUH; BA1IOH;
CADKIUH; CALCIUH; CHROHIUH; COBALT:
COPPER; IRON; LEAD; BAGNESIOB;
HANGANESE; BETALS; BOLIBDENDB;
NICKEL; PHOSPHORUS; POTASS IOB;
SILICON; SILTIR; SODIUH; STRONTIHH;
TIN; TITANIUI; T1NADIDH; ZINC;
BIOACCUHULATION ; HEALTH HAZARDS;
OCCDPATIONAL HAZARDS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(1) :1S5-165
Teraoka, H.
1981
Archives of
36(4): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(1): 155-165
N>
.p-
(NEXT PAGE)
-------
Scdiui
74110-23-5
Ha
»t» 22.98977, BP 97.82 C. BP 881.« C. »P t •> Hg at »40 C, 10 •• Hg at 546 C
(CONTINUED)
TISSUE
6780
Spleen
6781
Stomach
6782
Thyroid
gland
EIPOSOBE EODTE
.
ANALYTICAL
BETHOD
BS
BS
ES
NUHBEB
01 CASES
9
10
«
BANGE
Not given
Not given
Hot given
(BEIT
BEAN
6200 +OL- 1700 ppi
dry »t
4300 »or- 1200 ppi
dry vt
6800 tor- 1300 ppi
dry lit
PAGE)
GENEBAL IIFOBHATION
Nonal tissue
Japan
TONGUE; ZIBCOIIUB; EIE1ENTS; JiPJI;
ADULTS; 4DTOPSIES; aDHEKat GLANDS;
AOBTJ; BOIES; HEiBT; INTESTINES;
KIDNEIS; LI?EB; LUNGS; LTHPH NODES;
SPLEEN; PANCBE1S; STOIUCH; IHTBOID
GLANDS; TKACREA; ALOBINDII; BABIOH;
C1DBIDH; C1LCIDB: CHBOBIOB; COBALT;
CCPPEB; IRON; LEAD; HAGNESIDB;
8ANGANESE; BETALS; BOtTBDENDB;
NICKEL; PHOSPHOKOS; POTASSIDB;
SILICON; SILTED; SODI08; STBONTIOB;
TIN; TITANIOB; TANADIDH; ZINC;
BIOACCOBOLATION; HEALTH HAZABDS;
OCCUPATIONAL HAZABDS
normal tissue
Japan
TONGDE; ZIBCOHIdH; ELEBENTS; JAPAN;
ADULTS; AOTOPSIES; ADBENaL GLaNDS;
AOBTA; BONES; BEAST; INTESTINES;
KIDNEYS; LIVES; LUNGS; LTBPH NODES;
SPLEEN; PANCBEAS; STOBACH; THTEOID
GLANDS; TBACHEA; iLUBINUB; BABIOB;
CADBIOB; CALCIOB; CHBOBIUB; COBALT;
COPPEB; IBON; LEAD; HAGNESIOB;
BANGANISE; BETALS; BOLTBDEND8;
NICKEL: PHOSPROBD5; POTA3SIUB;
SILICON; SILVER; SODIUB; S1BOHTIUB;
TIN; TITANIOB; TAHADIOH; ZINC;
BIOACCHBULATI01I; HEALTH HAZARDS;
OCCUPATIONAL HAZABDS
Nonal tissue
Japan
TONGUE; ZIBCONIUH; ELEBENTS; JAPAN;
ADULTS; AUTOPSIES; ADBENAL GLANDS;
AOBTA; BONES; HEART; INTESTINES;
KIDNETS; LITBE; LONGS; LYHPH NODES;
SPLEEN; PAICBEAS; STOHACR; TBIBOID
GLANDS; TBACHEA; ALDHINUB; BABIUB;
CADBIUB; CALCIUB; CHBOBIOB; COBALT;
COPPEB; IKON; LEAD; BAGNESIUB;
BANGANESE; BETALS; BOLYBDENUH;
NICKEL: PHOSPHOBUS; POTASSIOH;
SILICON; SILTEB; SODIUB; STBONTIUB;
TIN; TITANIOB; VAHADItJB; ZINC;
BIOACCUBOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZABDS
5E7EBENCE
Teraoka* H.
1981
Archives of
Environaental Health
36[») I 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(») :155-165
Teraoka. H.
1981
Archives of
Environmental Health
36(4): 155-165
-------
lt« 22.98977, SP 97.82 C, EP 881.4 C, VP 1 •• Hq at 440 C, 10 •• Hg at 546 C
(COHTIHU1D)
6783
Tongue
6784
Trachea
Mot given
Not given
3000 +OE- 0 ppm dry
yt
8600 *or- 3400 ppm
dry »t
GENERAL I8FOBNATION
Normal tissue
Japan
TONGOE; ZIRCONIBB; ELEBENTS; JAPAN;
A DOITS; AUTOPSIES; ADRENAL GLANDS;
AORTA; BONES; RESET; IHTESTISES;
KIDNEYS; UTEB; LONGS; LYBPH NODES;
SPLEEN; PANCREAS; STOBACH; THTBOID
GLANDS; TRACHEA; ALOBINOB; BAilDB;
CADHIOB; CALCIOH; CHRONIUB; COBALT;
COPPER; IRON; LEAD; nAGNESIDH;
BANGANE5E: BETALS; HOLIBDENOB;
NICKEL; PHOSPHORUS; POTASSIOB;
SI1ICON; SILTEB; SODIOfl; STBONTIOB;
TIN; TITANIOB; TANADIHB; ZINC;
BIOACCOnOLiTION; HEALTH HAZARDS;
OCCOPATIONAL HAZARDS
Horaal tissue
Japan
TONGUE; ZIRCODIOH; ELEMENTS; JAPAN;
AEDLTS; ADTOPSIES; ADREHAL GLANDS;
AOETA; BONES; HEART; INTESTINES;
IQDNETS; LITEB; LONGS;. LTBCH NODES;
SPLEEN; PANCBEAS; SIOBACH; THIBOID
GLANDS; TBACBEA; ALOBIKOB; BABIOB;
CADBIUB; CtLCIDR; CHBOBIOB; COBALT;
COPPER; IBON; LEAD; BtGNESIOB;
HANGANESE; BETALS; HOLIBDENOB;
NICKEL; PHOSPHOROS; POTASSIOB;
SILICON; SILTEB; SODIOH; STBONTIUfl;
TIN; TITANIOH; VANADIOB; ZINC;
BIOACCOBOLATION; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(«): 155-165
Teraoka, R.
1981
Archives o£
Environmental Health
36(1): 155-165
Strontium
74«0-2»-6
SI
At* 87.62, HP 357 C. BP 1366 C, TP 10 mm Hq at 898 C, 1 mm Hq at 740 C
6785
Adrenal
gland
EXPOSURE BOOIE
E
ANALITICAL
HETHOD
ES
NOB BEE
OF CASES
7
BADGE
Not given
BEAK
0.41 *or- 0.20 ppm
dry »t
GENEBAL INFOEBATION
Normal tissue
Autopsies
Japac
JAPAN; ADDLTS; AUTOPSIES ; ADRENAL
GIANDS; AOETA; BOIES; BE JET;
INTESTINES; KIDNEtS ; LIVER; LONGS;
LTHPH NODES; PANCBEAS; SPLEEN;
STOBACH; THTBOID GLANDS; TRACHEA;
ALUflltTOB; BABIOH; CADBIOH; CALCIUB;
CHBOSIDH; COBALT; COPPER; IHOS; LEAD;
B1GNESIDB; 9ANGAHESE; BETALS;
HOLTBDENOH; NICKEL; PHOSPHOBOS;
POT1SSIOB; SILICON; SILTEE; SODIOB ;
STEONTIOB; TIN; TITANIOB; TAHIDKI8;
ZINC; BIOACCOBOL1TION; HEALTH
HAZABDS; OCCOPATIONAL HAZARDS;
TONGUE; ZIRCOBIDB; ELE BENTS
Teraoka, R.
1981
Archives of
Enviconnental Health
36(4): 155-165
(MBIT PIGB)
-------
strontium
71100-21-6
Sr
At» 87.62,
IIP 357 C, BP 1366 C, 7P 10 » Hg at 898 C, 1 •• Hg at 740 C
(CONTINUED)
TISSUE
6786
Aorta
6787
Bone
6788
Hair
6789
Heart
EXPOSURE ROUTE
ANALYTICAL
HETHOD
ES
ES
HI
ES
NUMBER
OF CASES
7
e
5
a) 8
b) 2
c) 3
d) 1
e) 1
BANGE
Not given
2.4110 (E-6J-113.3X10 (5-6)
q/cu en
a) Not given
b) 0.72-1.3 ppm
c) 1.2-7.1 ppm
d) Not applicable
e) Hat applicable
Dry «t
BEAM
2.1 +or- 0.68 ppn dry
lit
lit
16. 13X10 (E-6| g/cu cm
a) 0.24 *or- 0.08 ppm
b) 1.0 pp»
c) 3.1 ppn
d) 2. 3 ppm
e) 1.2 ppm
Dry »t
GENEEAL INFORMATION
_
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA: BONES; HEART;
INTESTINES; KIDNEYS; LITER; LONGS;
IYMPH NODES; PANCREAS; SPLEEN;
STOHACH; THYROID SLABDS; TRACHEA;
ALUMINUM; BARIDII; CADMIUM; CALCIUM;
CHBOMIOM; COBALT: COPPER; IRON; LEAD;
MAGNESIUM; MANGANESE; METALS;
MOLYBDENUM; NICKEL; EHOSPHOSOS;
POTASSIOB; SILICON: SILVER; SODIOB;
STRONTIUM; TIN; TITANIUM; VANADIDK ;
ZINC; BIOACCntlOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUM; ELEMENTS
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADEENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
1YHPH NODES: PASCEEAS: SPLEEN;
STOMACH; THYROID GLANDS; TRACHEA;
ALUMINUM; BABIOM; CADHI08; CALCIOM ;
CBBOMIDM; COBALT; COPPER; IRON; LEAD;
MAGNESIUM; MANGANESE; METALS;
MOLYBDENOM; NICKEL; PHOSPHORUS;
POTASSIOH; SILICON; SILVER; SODIOH;
SIBOBTIDM; TIN; TITAHIUM; VANADM8-,
ZINC; BIOACCOMOLATION; HEALTH
HAZARDS; OCCOPATION AL HAZABDS;
TCTGUE; ZIRCONIOM; ELEMENTS
3 en segments of single hairs
Soiie sanples belov detection limits
IRIDIDM; HAIR; FOSENSIC MEDICINE;
MEASUREMENT METHODS; ANTIMONY.;
ARSENIC; BROMINE; COPPER; GOLD;
ItlTHANUH; MANGANESE; MERCORY;
METALS; SELENIUM; SILVER: SODIUM;
SJEONTIOB; ZINC; INDUSTRIAL
ATMOSPHERES
a) Nornal healthy Hen
b) Chroaini plating workers
c) Chroiate refining vorkers
d) Airplane painter
e) Stone lason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEAET;
INTESTINES; KIDNEYS; LIVER; LONGS;
IYMPH NODES; PANCREAS; SPLEEN;
STOMACH; THYROID GLANDS; TRACHEA;
ALUMINUM; BAEIUM; CADMIUH; CALCIUM;
CHROMIDM; COBALT; COPPER; IRON; LEAD;
MAGNESIUM; MANGANESE; METALS;
MOLYBDENUM; NICKEL; PHOSPHORUS;
POTASSIUM: SILICON; SILVER; SODIUM;
STRONTIUM; TIN; TITANIUM; VANADIUM;
ZINC; BIOACCDMDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TONGUE: ZIRCONIUM; ELEMENTS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36 («) -.155-165
1981
Archives of
Environmental Health
36(4): 155- 165
Dybczynski, K.
Boboli, K.
1976
Journal of
Radioanalytical
Chemistry 31:267-289
Teraoka, H.
1981
Archives of
Environmental Health
36(») :155-165
(NEXT PAGE)
Is)
-P-
"•J
-------
Strontiui
7H40-2U-6
Sr
Its 87.62, IIP 357 C, BP 1366 C, VP 10 •• Hg at 898 C, 1 » Hg at 7I40 C
(COHTINOED)
TISSUE
6790
Intestine
6791
Kidney
6792
Livsr
EXPOSURE ROUTE
ANALYTICAL
HETBOD
__
ES
ES
ES
NOBBEB
OF OSES
10
a) 8
b) 2
c) 3
d) 1
e) 1
a) 9
b) 2
c) 3
d) 1
e) 1
BAHGE
Hot given
a) Hot given
b) 1.2-2.0 ppa
c) 0.39-4.5 pp»
d) lot applicable
e) Dot applicable
Dry vt
a) Hot given
b) 0.35-1.2 fpm
c) 2.0-1.2 ppi
d) lot applicable
e) Mot applicable
Dry vt
(KBIT
HE1H
0.54 *or- 0.22 ppa
dry wt
a) 0.38 *or- 0.09 ppa
b) 1.6 ppl
c) 2.3 ppl
d) 2.7 pp«
e) 0.81 ppi
Dry wt
a) 0.20 +or- 0.07 ppa
dry »t
b) 0.77 ppn
c) 3.3 pp«
d) 1.9 ppi
e) 0.79 ppi
Dry wt
P1GE)
GENERAL INTOBHATION
Norial tissue
Autopsies
Japan
JAPAH; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA: BONES; HEART;
INTESTINES; KIDNEYS; LIVES; LONGS;
LYHPH NODES: PANCREAS; SPLEEN;
STOHACH; THYROID GLANDS; TBACHEA;
ALDniiran; BAEIOB; CADBIOB; CALCIOK;
CBBOniOB; COBALT; COPPER; IBON; LEAD;
HAGNESIHH; BA8GANESE: HETALS;
NOLYBDENDH; NICKEL; PHOSPHOfiOS;
POTASSIDn; SILICON; SILJBB; SODIOH;
STEO»TIUH; TIN; TITASIOfl; VANADIHN;
ZINC; BIOACCOBULATIOH; HEALTH
HAZAEDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIBCOHIOB; ELEDENTS
a) Norial healthy »en
b) cbroHiaa plating vortcers
c) chronate refining workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; 1DBENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCREAS; SPLEEN;
STORACH; THYBOID GLANDS; TBACHEA;
ALOHINUH: BARIDB; CADHION; CALCIDK;
CHBOBIOn; COBALT: COPPEB; IBON; LEAD;
BAGBISIDB; BANGANESE; BETALS;
HOLYBDENOR; NICKEL; PHOSPHORUS;
POTASSIBS; SILICON: SILTBB ; SODItTHj
STBORTIOR; TIN; TITANIDR; TANADHJB;
ZINC; BIOACCDHULATION; HEALTH
HAZARDS; OCCUPATIONAL BAZABDS;
TCNGOE; ZIBCONIOB; ELEBBNTS
a) Nocial healthy «en
b) ChroMiuH plating workers
c) Chronate refining workers
d) Airplane painter
e) Stone Mason
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADBENAL
GLANDS; AOBTA; BONES; HEABT;
INTESTIVXS; KIDNEYS; LIVEB; LONGS;
LYHPH NODES; PANCSEAS; SPLEEN;
STOHACH; THYBOID GLANDS; TBACHEA;
ALORINOH; BABIOB; CADHIUK; CALCIOB;
CHROBIOB; COBALT; COPPER; IBON; LEAD;
BAGNESIUB: H1IGANESE; NETALS;
HOLYBDEIOH; NICKEL; PHOSPHOBOS;
POTASSIOR; SILICON: SILTEB; SODIOB;
STBONTIOB; TIN; TITANIOH; 7ANADIOB;
ZINC; BIOACCOBHLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGOE; ZIRCONIUn; ELEflENTS
Teraoka* H.
1981
Archives of
Environnental Health
36(»):155-165
Teraoka, H.
1981
Archives of
Environmental Bealth
36(«):155-165
00
Teraoka* H.
1981
Archives of
Environmental Health
36(4):155-165
-------
strontium
74HO-24-6
Sr
AtV 87.62,
6793
Liver
IIP 357 c, BP 1366 C, TP 10 •• Hg at 898 C, 1 » Bg at 740 C
(CONTINUED)
6794
Lung
6795
lymph
node
EXPOSURE BOOTS
ANALYTICAL
HETHOD
BS
ES
__
HUBBER
OF CASES
30
a) 12
b) 2
c) 3
ai i
e) 1
a) 3
b) 1
c) 3
3) 1
e) 1
BANGE
0.01 ng/g
net »t
a) Hot given
b) 1.7-2.1 ppm
d) Hot applicable
e) Hot applicable
Dry wt
a) Hot given
b) Not applicable
c) 3.2-111 ppi
d) Hot applicable
e) Hot applicable
Dry wt
BEAN
Hot given
a) 0.55 *or- O.It ppu
b) 1.9 ppm
c) 4.2 Ppm
d) 2.4 ppm
e) 2.2 PP«
Dry wt
a) 3. 4 +or- 1 .6 ppa
b) 3.5 pp»
c) 7. 1 ppa
d) 4. 1 ppn
e) 5.0 ppm
Dry *t
GENERAL IBTORHATIOH
Category 3 as proposed by
International Rorkshop on Monitoring
Banking (trace eleaent of
eovironMental importance not included
in first priority list)
Autopsies, Baltimore, HD,
flinneapolis, an, and Seattle, Hi
BAETIiSD; RIHIESOTA: WJSHIHGTOH;
AUTOPSIES: LIVES; HEASUBEn EOT
aiTHODS; ALnnisnM; ARTHIORI; ABSEHIC;
EABinn; cAoaioa; cHBonioB; COBALT;
CCPPEB; FtOOEISE; IROH; LEAD;
HAH6AHESE; BEBCUEY; BOLIBDEHOn ;
NICKEL; EOBIDIOB; SELERIOH; SILTEB;
STBOHTIOB; THJ1LIOB; Till; VAMADIDH;
ZIHC; POPOLATIOH EXPOSOBE
a) Nor Hal healthy »en
b) Chroiiai plating workers
d) Airplane painter
e) stone nason
Autopsies
•Japan
JAPAH; AD0LTS; AUTOPSIES; AOBEHAL
GLAHDS; AOBTA; BONES; HEABI;
INTESTINES; KIDHEIS : LITER; LOHGS;
LTBPB NODES; PANCBEAS; SPLEEN;
STOKACH; THYROID GLAHDS; TBACHEA;
ALDBIHOB; BABIDD; CADHIDH; CALCIIIB;
CBBOKinB; COBALT; COPPEB; IBOH; LEAD;
HAGHESIOH; 8AHGAHESE; HETALS;
HOLTBDENOB; NICK El; PHOSPHOBUS;
POTASSIOH; SILICON; SILTEB; SODIOfl;
SIBOHTIHII; TIH; TITAMDB; VAHADIOH;
ZIHC; SIOiCCOnnIJTION; BEAITH
HAZARDS; OCCUPATIONAL HAZARDS;
TOSGOE; ZIBCOHIUB; ELEBE8TS
a) Honal healthy men
b) chroniui plating iiorlcers
c) Chroiate refining workers
d) Airplane painter
e) stone aason
Autopsies
Japan
JAPAH; ADULTS; AUTOPSIES; ADBEHAL
GLAHDS; AOBTA; BOHES; HEABT;
IHTESTIHES; KIDHEIS: LITBB; LDHGS;
LTHPH HODES; PAHCBEAS; SPLEEH;
STOKACH; TBIROID GLAHDS; TBACHEI;
ALU9IHOH-. BASIOS; CADHIO!!; CALCIOH;
CBBOalUH; COBALT; COPPEB; ISOH; LEAD;
IUGHESIOH; HAHGAHESE; HETALS;
BOLTBDEH0H; HICKEL; JHOSPHOHOS;
POTASSIUB; SILICON; SILTEB; SODIUB;
STKOHTIUH; TIH; TITAHIOB; TAHADIUB;
ZIHC; BIOACCOBOLATIOH; HEALTH
HAZARDS; OCCUPATIOHAL HAZARDS;
TOHGUE; ZIBCOHIDH; ELEBEHTS
REFERENCE
Harrison, S.H.
Zeisler, R.
1981
EPA 600/S1-81-025, 6
PP-
Teraoka, H.
1981
Environmental Health
36(4): 155-165
Teraoka, R.
1981
Archives of
36(«) : 155-165
(HEIT PAGE)
K3
.p-
-------
StrontiuB
1IKIO-2I4-6
Sr
At» 87.62, HP 357 C, Bf 1366 C, VP 10 BB Bg at 898 C. 1 >• Hg at 710 C
(CONTINUED)
TISSUE
6796
Pancreas
6797
Spleen
6798
stoBach
EXPOSURE ROUTE
AHALYTIC1L
BETHOO
ES
ES
ES
SUB BEE
OF OSES
5
a) 9
b) 2
c) 3
d) 1
e) 1
10
BASSE
Mot given
a) lot given
b) 0.40-2.7 ppi
c) 1. 1-5.5 ppB
d) Not applicable
e) Hot applicable
Dry lit
Not given
MEAN
0.21 »or- 0.06 ppB
dry vt
a) 0.23 *or- 0.07 ppa
b) 1.6 pp«
c) 3.8 ppB
d) 5. 2 ppm
e) 0.91 pp»
Dry »t
0.5» *or- 0.22 ppB
dry »t
GENERAL INFOBHATION
NorBal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEABT;
INTESTINES; KIDNEYS; LITER ; 10NGS;
LIBPH NODES: PANCBEAS; SPLEEN;
STOMACH; THYROID GLANDS; TBACHEA;
JlOfllsrj.l; BiSIOH; C1DRIB.1; CJICIH":
CBBOHIOH; COBALT; COPPEB; IBON; LEAD;
HAGNESIDH; 9ANGANESE; HETALS;
BOLIBDENOH; NICKEL; PHOSPHOBDS;
PCTASSIBfl; SILICOS; SILTEB; SODIDB ;
SlBONTinn; TIN; TITASIOn; TABADimij
ZINC; BIOACCOBtlLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGOE; ZIBCONIOB; ELEBEHTS
a) Norial healthy Ben
b) chroniui plating workers
c) chroHate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JiPAH; ABOITS; IOTOPSIIS: 1BBHK1I.
GLANDS; AOBTA; BOHES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
1YIPH NODES: PANCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TBACHEA;
ALDBINDH; BARIDB; CADBIHB; CALCIUH;
CHBOBIOB; COBALT; COPPER; IRON; LEAD;
BAGNESIDB; BANGANESE; B3TALS;
BOLYBDENDB; NICKEL; PHOSPHOROS;
POTASSIOB; SILICON; SILVER; SODIOH;
STBONTlnfl; TIN; TITANIOB; TANADIDB;
ZINC; BIOACCOHOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGOE; ZIRCONIUB; ELEBENTS
NorBal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BOHES; HEART;
INTESTINES; KIDNETS ; LIVER: LUNGS;
LYBPB NODES; PANCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
ALOBINUB; BABIOB; CADBIUB; CALCIUB;
CHROHIUH; COBALT: COPPER; IRON; LEAD;
BAGNZSIUB; BANGANESE; HETALS;
BOLYBDENUH; NICKEL; PHOSPHOROS;
fOTASSIUB; SILICON; SILVER; SODIDfl;
STRONTIOH; TIN; TITANIDH; VAHADIUH;
ZINC; BIOACCUBDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGDE; ZIRCONIUB: ELEMENTS
REFERENCE
Teraoka , H.
1981
Archives of
EnvironBental Health
36(0) :155-165
Teraoka, H.
1981
Archives of
36(lt) : 155-165
Teraoka* H.
1981
Archives of
EnviEonBentaL Health
36(»): 155-165
_
INEZ! PAGE)
NJ
Ln
O
-------
Strontiui
74HO-24-6
Sr
ltd 67.62, HP 357 C. BP 1366 C, ?P 10 •« Hg at 896 C, 1 » Hg at 740 C
(CONTINUED)
TISSUE
6799
Thyroid
gland
6800
Tongue
6601
Trachea
EXPOSURE EOUTE
ANALYTICAL
METHOD
.
ES
ES
ES
NUMBER
OF CASES
«
2
2
BINGE
Hot given
Not given
_
Not given
MEAN
0.61 +or- 0.21 pp«
dry wt
0.21 +or- 0 ppn dry
wt
0.79 »or- 0.44 ppm
dry »t
GENERAL INFORMATION
Nonal tissue
Autopsies
Japan
JAPAN; ADULTS; ADTOPSIES; ADRENAL
GLANDS; AOBT1; BOIES; BEAST;
IBTESTIBES; KIDNEYS; LIVER; LDNGS;
LIUPH MODES; PANCBEAS; SPLEEN;
STOHACH; TRIBOID GLANDS; TBACHEA;
ALUHIBOn; BABinn; CIDBIIjn; CALCIOIt;
CHEOBIOB; COBALT; COPPEB; IBON; LEAD;
nAGSEsiaa: MANGANESE; METALS;
HOLTBDENOfli NICKEL; PHOSPHCROS;
POtASSIUnS SILICOH; SIL'EB ; SODIOK;
STBOBTIOB; TIN; TITANIOT; VANABIOB;
ZINC; BIOtCCOBDLATION; HEALTH
HAZARDS; OCCUPATIONAL BAZA EDS;
TONGUE; ZIBCOHIOB; ELEMENTS
Horial tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDHETS; LIVES; LUNGS;
LYMPH NODES; PANCBEAS; SPLEEN;
STOMACH; THYBOID GLANDS; TRACHEA;
ALUMINUM; BABIUM; CADMIU1; CALCIOH;
CHROMIUM; COBALT; COPPEB; IBON; LEAD;
MAGNESIUM; MANGANESE; METALS;
SOUBBEMB; NICKEL; PHOSPHORUS;
POTASSIUM; SILICON; SILVEB; SODIUM;
STBONTIOM; TIH; TITANIUM; VANADIUM;
ZINC; BIOACCONULATION; HEALTH
HAZABDS; OCCUPATIONAL RAZABDS;
TONGUE; ZIBCONIUfl; ELEMENTS
Nor«al tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LYMPH NODES; PANCREAS; SPLEEN;
STOMACH; THYROID GLANDS; TBACHEA;
ALUMINUM; BABIUM; CADMIUM; CALCIUM;
CHROMIUM; COBALT; COPPER; IBON; LEAD;
MAGSESIOS; MANGANESE; SETALS;
HOLYBDENOB; NICKEL; PHOSPHORUS;
POTASSIUM! SILICON: SILVER; SODIUM;
STEONTIUB; TIN; TITANIUI; VANADIUM;
ZINC; BIOACCUaDLATION; HEALTH
HAZABDS; OCCUPATIONAL RAZABDS;
TONGUE; ZIRCONIUM; ELEMENTS
REFERENCE
Teraoka, H.
1981
Archives of
Environaental Health
36 (4): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36 (S) : 155-165
Teraoka, H.
1981
Archives of
36(4): 155-165
-------
Styrene (8 ci)
Benzene, ethenyl- (9 CD
100-112-5
C8-H8
B» 101. 11, HP -31 C. BP 145-146 C, VP 39.1 ati at 374. 1 C
6802
Blood
6803
Breath
EXPOSURE BOOTE
Inhalation
Deraal
Inhalation
Demi
ANALYTICAL
KETHOD
GC/BS
GC/BS
HOB BEE
OF CASES
8
8
HAHGE
a) Hot given
b) Hot given
c) Hat given
d) Hat given
e) Hat given
f ) Hat given
g) Hat given
h) Hat given
i) Hat given
j) Hat given
k) Hot given
1) Hot given
a) Hot given
b) Hot given
c) Hot given
d) Hot given
e) Hot given
£) Hot given
g) Hot given
h) Hot given
i) Hot given
j) Hot given
k( Hat given
1) Hot given
-
(HEX!
BEAU
a) 0. 16 tor- 0.06
ug/Bl
b) 1.22 »or- 0.69
ug/Bl
c) 0. 17 tor- 0. 11
ug/nl
d) 0.17 tor- 0.08
ug/Bl
e) 0.31 tor- 0.14
ug/Bl
f) 0. 16 tor- 0. 05
ug/ai
g) 0. 17 tor- 0.07
ug/il
h) 0.94 tor- 0.32
ug/nl
i) 0.20 tor- 0.08
ug/Bl
j) 0.16 tor- 0.09
ug/Bl
k) 0.20 tor- 0. 13
ug/nl
1) 0. 12 tor- 0.01
ug/Bl
a) 1.59 tor- 0.84
ug/1
b) 9.46 tor- 2.46
ug/1
c) 2.04 tor- 0.78
ug/1
d) 1.70 tor- 0.55
ug/1
e) 2.86 tor- 1.03
ug/1
£) 1.37 tor- 0.26
ug/1
g) 2.07 tor- 1.49
ug/1
h) 8.55 tor- 2.36
ug/1
i) 1.74 tor- 0.54
ug/1
j) 1.82 tor- 0.59
ug/1
k) 2.98 tor- 1.76
ug/1
1) 1.26 tor- 0.55
ug/1
P4GE)
GENERAL IHFORBATION
a) Pre-work, no protective clothing
b) End of 6 hr work-shift, group a)
o) 16 hr post-shift, group a)
d) pre-vork, wearing respirator
e) End of 8 hr vcrk-shift, group d)
f) 16 hr post-shift, group d)
g) Pre-work, wearing polvvinyl
alcohol gloves and protective
clothing
h) End of 8 hr work-shift, group g)
i) 16 hr post-shift, group g)
j) pre-work, wearing gloves.
protective clothing, and respirator
k) End of 8 hr work-shift, group j)
1) 16 hr post-shift, group j)
Hean aibient air levels during
wort- shift, 60-90 PPB (est listed froB
graph)
End of work-shift levels for groups
using respirator significantly lower
than groups not using respirator
by following aorning
Dorkets with extensive exposure in
aannfacture of fibrous glass boats, 4
SBOkers, 4 nonsBokers
IDOLTS; BLOOD: BEEiTH; OHIHE;
STTREHES; tie POILDTIOH; IHDOSTRIAL
JTflOSPHEHES; IHDOSTRIAL PLAHTS;
IHHAtATIOn; BETABOIISH; 9ETABOLITES;
OCCUPATIOHAl HAZARDS; INDUSTRIAL
CHEMICALS; INDUSTRIAL HTGIZHE
a) Pre-work, no protective clothing
b) End of 8 hr work-shift, group a)
c) 16 hr post-shift, group a)
d) Pre-vork, wearing respirator
e) End of 8 hr wcrk-shift, group d)
f) 16 hr post-shift, group d)
g) Pre-work, wearing polvvinyl
alcohol gloves and protective
clothing
h) End of 8 hr work-shift, group g)
i) 16 hr post-shift, group g}
j> Pre-work, wearing gloves.
protective clothing , and respirator
k) End of 8 hr wcrk-shift, group j)
1) 16 hr post-shift, group j)
Rean tiBe of saBple 10.2 tor- 6.3 Bin
work-shift, 60-90 ppa (estiBated froB
graph)
Dse of respirator significantly
reduced level in expired breath
All values returned to control levels
by following aorning
Bannfactnre of fibrous glass boats, 4
SBokers, 4.nonsBokers
« BOLTS; BLOOD; BREATH; 0BIRE;
STHEWES; AIR POILDTIOH; IHDOSTRIAL
ATROSPHERES; IHDOSTRIAL PLAHTS;
I1HALATIOI; HETABOLISR; BETIBOLITES ;
OCCOPATIOHAL HAZARDS; IHDOSTBIAL
CBEHICALS; IBDVSTRIAL HTGIXV.Z
REFERENCE
Brooks, s.n.
Anderson, L.
EBBett, E.
Carson, A.
Tsay. J.-r.
Ella, 7.
Buncher, S.
Karbowsky, R.
1980
Archives of
35(5) :287-294
Brooks, S.n.
Anderson, L.
Eiaett, E.
Carson, A.
Tsay, J.-I.
Elia, V.
Buncher, R.
Karbowsky, R.
1980
Archives of
EnvironBental Health
35 (5) : 287-294
N3
Ln
NJ
-------
styrene (8 CI)
Benzene, ethenyl- (9 CI)
100-12-5
C6-B8
B» 104.10, IIP -31 C, BP 145-1*6 C, VP 39.4 atm at 374.4 C
(CONTINUED)
TISSUE
6804
Urine
6805
Urine
EXPOSURE ROUTE
Inhalation
Dermal
ANALYTICAL
HETBOD
SC
6C
SOU BEE
OF OSES
8
55
BANGE
a) Hot given
b) lot given
c) Hot given
d) Hot given
e) Hot given
f) Hot given
g) Hot given
h) Hot given
a) 16-2500 ig/g
cceatinine
b) <5-2200 »g./g
creatinine
HEAH
a) 149 *or- 108 »g/g
creatinine
b) 1330 *or- 591 mg/g
creatiaine
c) 248 tor- 1 10 mg/g
creatinine
d) 194 *or- 1 15 mg/g
creatinine
e) 128 +or- 87 mg/g
creatinine
f) 301 *or- 165 mg/g
creatinine
g) 280 tor- 217 mg/g
creatinine
h) 262 tor- 252 iig/g
creatinine
a) Hot given
b) Not given
GENERAL INFORBATION
a) Handelic acid, pre-vork, no
protective equipment
b) Handelic acid, end of shift, no
protective equipment
c) Handelic acid, pre-uork.
protective equipment
d) Handelic acid, end of shift.
protective equipment
e) Phenylglyoxylic acid [PGl~],
pre-vork, no protective equipment
f) PSA, end of shift, no protective
equipment
g) PSA, pre-vork, protective
equipment
h) PGA, end of shift, protective
equipment
styrene metabolites
Hean aabient air levels, 60-90 ppm
(estimated fro« graph)
Workers with extensive exposure in
Manufacture of fibrous glass boats, 4
smokers, 4 nonsiokers
A DOITS; BLOOD: BREATH; URINE;
STIREKES; AIR POILDTIOH; INDOSTRIAL
ATMOSPHERES; INDUSTRIAL PLANTS;
INHALATION; HETABOLISn; HETABOLITES ;
OCCUPATIONAL HAZARDS; INDUSTRIAL
CHznicALS: IHDOSTRIAL HYGIENE
a) Handelic and phenylglyozylic acids
b) Kandelic acid only
After stvreue eiposure of 2.8-83.4
pp» (8 hr tine-weighted average)
Post shift saiples
Plastics factory employees
ADDLTS; DHITED STATES; URINE;
HEASDRBHEHT BET HODS; STTREHES; HEALTH
HAZARDS; INDUSTRIAL ATMOSPHERES;
METABOLITES; OCCUPATIONAL HAZARDS;
INDUSTRIAL CHEHICALS
REFERENCE
Brooks, S.K.
Anderson, L.
ElHtt, E.
Carson, A.
Tsay. J.-Y.
Ella, 7.
Buncher, R.
Karbovsky, R.
1980
Archives of
Environmental Health
35(51:287-294
Elia, V.J.
Anderson, L.A.
BacOonalS, T.J.
Carson, A.
Buncher, C, R.
Brooks, S.a.
1980
Anerican Industrial
Hygiene Association
Journal 41:922-926
Succinaiic acid, 3-aiino-N-(alpha-carboxyphenethyl)-, H-iethyl ester,
L-Chenylalanine, N-L-alpha-aspartyl-, 1-iethyl ester (9 CI)
22839-47-0
C14-H18-N2-05
KB 294.30, «P 246-247 C
stereoisoier (8 CI) (TAN)
TISSUE
6806
Blood,
plasaa
EIPOSORE ROUTE
Inqestion
ANALYTICAL
BETHOD
NOBBER
OF CASES
34
RANGE
_
a) 5.86-12.0 uiol/dl
b) 4.83-8.95 u»ol/dl
c) 5.92-15.1 u»ol/dl
d) 6.40-7.84 a»oVdl
e) 4.40-5.46 u«ol/dl
f) 3.77-4.29 uiol/dl
HE A
a) Not giv
b) Not giv
c) Hot giv
d) Not giv
e) Not giv
£) Not giv
H
GEHERAL IHFORHATION
- -
a) Phenylalanine, 12 noraal Hales
b) Phenylalanine, 10 normal feaales
c) Phenylalanine, 12 females
heterozygous to phenylketonuria
d) Tyrosioe, same as a)
e) Tyrosine, same as b)
f) Tyrosine, same as c)
Range of means
Dose 34 mg/kg aspartame
Slower rate of metabolism of
CALIFORNIA; IOWA; BLOOD PLASHA; AHINO
ACIDS; SWEETENING AGENTS
REFERENCE
Stegink, L. D.
Koch, 5.
Blaskovics, B.E.
Filer, L.J., Jr.
Baker, G.L.
BcDonnell, J.E.
1981
Toxicology 20:81-90
-------
Sulfide, methyl propyl (3 CI)
Propane, 1-(aethythio)- (9 CI)
3677-15-4
C4-H10-S
KM 90.19, BP -113 C, BP 95.54 C
TISSUE
6807
Breath
EXPOSURE ROUTE
ANALYTICAL
BETHOD
GC/HS
NDBBER
OF CASES
28
BADGE
1-8.4 ng/1
.-
3 ng/1
GENERAL INFORBATION
Estiaated froa graph
Healthy 18-60 yc olds, nonsmokers.
Rigid protocol 14 days before and
during study to aininize nunber and
aoount of exogenous constituents.
SDOLTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COHPOONDS; CHLOROBEHZENES
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, H.P.A.
1977
Journal of
Chromatographic Science
15:239-244
tert-Butyl disulfide (8 CI)
Disultide, bis( 1,1-di«ethylethyl) (9 CI)
110-06-5
C8-H18-S2
B« 178.36
6808
Breath
EXPOSURE ROUTE
ANALYTICAL
BETHOD
GC/BS
NOSBEB
OF CASES
28
BANGS
.
0.1-4 ng/1
__
0.65 ng/1
GENERAL INFORMATION
Estiaated froa graph
Healthy 18-60 yr olds, nonsaokers.
Rigid protocol 14 days 'before and
during study to Minimize nunber and
aaount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGANIC COBPOUNDS; CHLOROBF.HZENES
Krotoszynski, E.
Gabriel, G.
O'Neill, H.
Claudio, B.P.A.
1977
Journal of
Chroma tographic Science
15:239-241
NJ
Ul
Thalliui
7140-28-0
Tl
Att 201.37, «P 303.5 C, BP 1457 C, ?P 1 •• Hg at 825 C, 10 •• Bg at 1000 C
TISSUE
6809
Liver
EXPOSURE ROUTE
ANALYTICAL
BETHOD
NUBBEB
OF CASES
30
BAHGE
0.001-0.009 ug/g
net lit
HEAD
No^ given
GENERAL IVF08BATICN
Category 1 (first priority eleftent)
as proposed by International Horkshop
on Honitoring Environaental Baterials
and Speciaen Banking
Autopsies, Baltiaore, HD,
Binneapolis, BN, and Seattle, HA
BIRTLAND: BINNES01A; BASHINGTON;
AUTOPSIES; LITER; BBASOREBEBT
BETRODS; ALUHINUIt; ANTIHONI; ARSENIC;
BAFIDB; CADBIUB; CHEOHIUB; COBALT;
COPPER; FLUORINE: IRON; LEAD;
BANGAHESE; BEBCUR!; HOLYBDENUB,
HICKEL: ROBIDIUB; SBLEHUB; SILVER;
SIRONTIUB; THALLIHB; Tin; TANADIUB;
ZINC; POPULATION EXPOSURE
Harrison, S.H*
Zeisler, R.
Wise, S.A.
1981
EPA 600/S1-81-025, 6
pp.
-------
Thiocyanlc acid, ion(l-) (8 CI)
Thiocyanate (9 CI)
302-04-5
C-S-S
MS 58.08
TISSUE
6810
Blood
Thiocyclopen
( TISSUE
6811
Breath
EKPOSORE ROUTE
ANALYTICAL
METHOD
AAS
HDBBER
OF CASES
72
RANGE
...
a) Hot given
b) Not given
c) Hot given
d) Hot given
KEAN
a) 38.6 »or- 26.7
UfflOl/1
b) 100.9 *or- 50.3
uaiol/l
c) 33.0 +or- 22.8
d) 81.3 +OC- 39.1
amoi/1
GEHERAL INFORMATION
a) Maternal blood, 31 nonsiokers
b) Maternal blood, 41 smokers
c) Cord blood, 31 nonsnokers
d) Cord blood, 41 smokers
a), b) during active labor
b) significantly greater than a)
d) significantly greater than c)
Mean age 22 and 23 yr, mean infant
birth lit 30911 and 3136 g, mean
gestation time 39.0 and 39.4 wk for
smokers and nonsnokers, respectively.
OB
CBIO: ADULTS; NEBBORH; BLOOD:
P1BCEHTA; COMPARATIVE EVALUATIONS;
CSDMI0M; MET4LS; THIOCYAHATES;
EICACCDMULAT10H; HEALTH HAZAHDS;
PBEGHBHCY; SBOKIHG
FEFEBEHCE
Kuhnert, P.M.
Kuhnert, B. R.
Bottoms, S. F.
Erhard, P.
1982
Obstetcics and
Gynecoloqy 112 : 1021
ane (Ho postings in CHEMLINE) .
EXPOSURE ROUTE
18ALY.TICHL
METHOD
GC/MS
BOBBER
OF CASES
28
BASGE
0.28-2.8 ng/1
SEAN
0.9 ng/1
GEHEEAL IHFORMATIOS
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
Eigid protocol 14 days before and
JttllTS; BBEATH; ALCOHOLS; CHLOEINE
OEGAHIC COMPODHDS; CHLOSOBESZEHES
REFERENCE
Krotosz ynsHir B.
Gabriel, G.
O'Neill, H.
Claudio, n.p.A.
1977
Chromatographic Science
15:239-2«it
Thioether (9
C4-H10-S
K)
Ul
Ul
postings in CBEBLISE).
TISSUE
6812
_
EXPOSURE BODTE
Inhalation
ANALYTICAL
METHOD
Chem
NUMBER
OF OSES
224
RANGE
a) Mot given
c) Not given
d) Hot given
e) Hot given
f) Not given
g) Not given
BEAH
a) 47 »or- 1.8
b) 37 *or- 1.6
umol/mmol creatinine
c) 77 »or- 8.5
d) 42 »or- 2. 3
uiuol/mmol creatinine
e) 115 +or- 20
umol/mmol creatinine
i) 74 +or- It
umol/muol creatiaine
g) 57 +or- 3
uaal/maol creatinite
S.E.
GENERAL INFORMATION
a) 90 men, workers
c) 23 women, workers
d) 48 women, controls
f) 8 women, moderate skin
contamination
g) 3 women, light sKin contamination
Thioether levels indicative of
exposure to alkylating agents
Data also given by department and
curing status of rubber
Specimens collected after 8 hr work
day on Fri.
Rubber plant employees, office
workers.
URINE: INDUSTRIAL HYGIENE; INDOSTPIAI
MEDICINE; HEALTH HAZARDS; INDUSTRIAL
PLANTS; OCCUPATIONAL HAZARDS: BUBBBR
THIOETHEPS; INDUSTRIAL CHEMICALS
Kilpikari, I.
1981
British Journal of
Industrial Medicine
38:98-100
-------
Thorium, isotope of mass 228
14274-82-9
Th
B« 232.0381, HP approi 1750 c
TISSUE
6813
Body
6814
Urine
EXPOSURE FOOTE
Inhalation
Inhalation
ANALYTICAL
METHOD
ES
Radiometry
ES
Radiometry
NOBBEB
OF CASES
1
1
BANGE
at Not given
b) Not given
cj Not given
d) Not given
e) Not given
f) Not given
g) Not given
h) ot given
i) ot given
11 ot given
k) ot given
1) ot given
») Not given
n} Not given
9-0.3 pCi/day
HEAN
a) 11.2 to - 0.8 aCi
b) 10.5 to - 0.8 nCi
c) 14.7 to - 0.9 nCi
d) 8.3 tor 0.9 nCi
e) 13.2 to - 1.0 nCi
f) 10.1 to - 1.0 nCi
g) 7.7 tor- 0.3 nCi
h| 11.4 tor- 0.3 nCi
i) 8.6 tor- 0.3 nci
i) 6 nCi
k) 4 nCi
1) 2 nCi
ml 1.5 nci
n) 0.75 nCi
Not given
GENERAL INFOBBATION
a) 0
b) 5
c) 15
d) 47
e) 68
f| 103
g) 187
h) 257
i) 327
j) 500
k) 1000
1) 1500
I) 2000
n) 2500
Days after first measurement
Values are Bi-212 content from
whole-body counting
3) -n) estimated from graph
oxide form, between Sept 1962 and Dec
1963
THOBIDfl; BISBUTB; INDUSTRIAL
ACCIDENTS; I8HILATIOS; SIDIOJOCLIDES;
BOOT; URINE; IN TI»0 ANALYSIS
Alpha-activity 0 to 2600 days after
day of first measnrment
Laboratory worker contaminated,
presumably through inhalation of
thorium in oxide form, between Sept
1962 and Dec 1963
THOBIUH; BISSOTH; INDUSTRIAL
ACCIDENTS; INHALATION; RADIONOCLIDZS;
BODY; URINE: IN VITO ANALYSIS
REFERENCE
Newton, D.
Rundo, 3,
Eakins, J.D.
1981
Health Physics
40:291-298
Newton, D.
Bundo, J.
Eakins, J.D.
1981
Health Physics
40:291-298
Tin
7MO-31-5
£c
At« 118.69. HP 231.9 C, BF 2507 C. It 1 •• Hg at 1610 C, 10 mm Hg at 1990 C
TISSUE
6815
Adrenal
gland
EXPOSURE BOOTS
UNilVTicAL
(1ETBOD
IS
H OH BEE.
Of CtSES
7
BINGE
Hot given
(un
HE1N
0.82 tor- 0.48 ppm
dry wt
P1GE)
GESEBAL INPOB81TION
Normal tissue
Autopsies
Japan
JAPAN; JDDLTS; AUTOPSIES; ADEEHAI,
GI.ASDS; AORTA; BONES: HEART;
INTESTINES; KIDIEIS; LI7SR ; LDNSS;
IIIPB NODES: PAHCBEAS; SPLIEN;
STOHACB; THTBOID GLANDS; TBACBEA:
ALOHINOH; BARIOH; CADnum; CAlcrOT:
CBBOgiDB; .COBALT; COPPEB; IBON; LEAD;
HAGSESIUn; HAHGAHESE; BXTALS;
nOLTBDENUH; NICKEL; PHOSPH08DS;
pOTASSina; SILICON; SILTIB; soDioa:
STBONTIOB; TIN; TITANIDB; VANADIOB :
ZINC; BIOACCUHULATIOB; HEALTH
HAZARDS; OCCOPlTIOd AL HAZAItDS;
TONGOE; ZIBCONIOH;' BLEHINTS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4) : 155-165
-------
Tin
7HBO-31-5
Sn
At« 116.69, HP 231.9 C, BP 2507 C, VP 1 •• Hg at 1610 C, 10 •• Hg at 1890 C
(CONTINUED)
TISSUE
6816
Aorta
6817
Bone
6818
Bone
EXPOSURE ROUTE
ANALYTICAL
METHOD
ES
ES
«A
NUMBER
OF CASES
7
5
a| 7
b) 5
RANGE
Not given
Not given
a) 0.03-1.2 ppi
b) 0.06-1.4 ppi
(NEIT
MEAN
0.71 *or- 0.39 ppi
dry wt
al tissue
Autopsies
Japan
JAPAN; ADULTS: AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEAFT;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LYMPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TEACHEA;
ALUtllHUH; BARIUM; CADMIUM; CALCIUM:
CHROMIUM; COBALT: COPPER; IRON; LEAD;
MAGNESIUM; MANGANESE; METALS;
MOLYBDENUM; NICKEL; PHOSPHORUS:
POTISSHJH; SILICON; SIL7EP.; SODIHH;
STRONTIUM; TIN; TITANIUM; VANADIUM;
ZIBC; BIOACCOMULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE: ZIRCONIUM; ELEMENTS
a) Exposed group
b) Controls
Autopsies, fenur
05-75 yr old factory workers, Sweden.
Controls fro* unpolluted areas
ANTIMONY; A6SENIC; CADMIUM; COPPED;
LEAD: MERCURI; SELENIUM; SILVER; TIN;
ZINC; BIOACCOMD1.ATIOB: INDBSTRIAL
ATMOSPHERES; INDUSTRIAL PLANTS;
POPULATION EXPOSURE; SMELTERS; BONES;
PEMUE; COMPARATIVE EVALUATIONS;
SDEDEN; AUTOPSIES; OCCUPATIONAL
HAZARDS; METALS
Teraoka, H.
1981
Archives of
Environmental Health
36(4):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(») : 155-165
K)
t_n
—I
Lindh, 0.
Brune, D.
Nordberg, G.
Wester, P.-O.
1980
Science of the Total
Enviroment 16:109-116
-------
Tin
7440-31-5
Atw 118.69, HP 231.9 C, BP 2507 C. IP 1 mi Hg at 1610 c, 10 am Hg at 1890 C
(CONTINUED)
TISSUE
6819
Heart
6820
Intestine
6821
Kidney
EIPOSUBE ROUTE
ANALYTICAL
BETHOD
ES
ES
ES
NUMBER
OF CASES
a) 8
b) 2
C) 3
d) 1
e) 1
10
a) 8
b) 2
c) 3
e) 1
BANGE
a) Mot given
b) 0.38-0.59 ppm
c) 0.45-1.1 ppm
A) Nat applicable
e) Sot applicable
Dry wt
Not given
a) Not given
b) 0.40-1.7 ppn
c) 0.36-1.6 ppn
e) Not applicable
Dry vt
BEAU
a) 0.59 »or- 0.25 ppa
b) 0.48 ppm
c) 0.79 tt"
d) 0.31 ppn
e) 0.15 ppm
Dry wt
0.88 +or- 0.55 ppm
dry w t
a) 0.72 +or- 0.25 pfcim
b) 1.0 ppm
c) .87 ppm
e| 0.33 ppm
Dry wt
GENBBAL INFOBBATION
a) Normal healthy nen
b) Chromium plating workers
c) Chromate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN: ADDLTSj AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEABT;
INTESTINES; KIDNEYS; LIVEB; LUNSS;
LTBPH HODES; PANCREAS; SPtEES;
STOBACH; THTBOID GLANDS; TBACHEA;
AiuniNun; BjBiui; cADniui; cALCinn;
cHRoniun: COBALT: COPPER; IRON: LEAD;
SAGSESION; BANGANESE; BETALS;
BOLTBDENUB; NICKEL: PHOSPHORUS;
PCTASSIUB; SILICON: SILVER; SODIUS;
S1ROBTIU1; TIN; TITANIU1; VA8ADIUR ;
ZIHC; BIOACCUBULATION; HEAtTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZI8CONIUB; ELEMENTS
Normal tissue
Autopsies
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS: LIVER; LUNGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBSCH; THYBOID GLANDS; TBACHEA;
ALDBISUB; BABIOH; CADBIUB; CALCIUB;
CBSOBII1B; COBALT; COPPER; IRON; LEAD;
PAGNESIU1; BANGABESE; HETALS;
BOLTBDEBOfl; NICKEL: PHOSPHOSUS;
POTASSIoa; SILICON; SILVER; SODIOd;
STRONTIUB; TIN; TITASIDB; VANADItJB;
ZINC; BIOACCDHULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCOHIUB; ELEBEHTS
a) Normal healthy men
b) chromiufi plating workers
c) Chromate refining workers
e) Stone mason
Autopsies
Japa n
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEART;
INTESTINES: KIDNEYS; LIVES; LUNGS;
1YBPH HODES; PANCBEAS; SPLEEN;
STOHACH; THYBOID GLANDS; TRACHEA;
ALHBINUB; BABIUa; CADBIU1: CSLCIOB;
CHPOBIUB; COBALT; COPPEB: IRON; LEAD;
BAGNESIUB; MANGANESE; BETALS;
BOLYBDENUB; NICKEL: PHOSPHORUS;
POTASSIUS; SILICON; SILVER; SODI09;
STSONTIUB; TIB; TITANIUB; VASADIU9;
ZINC; BIOACCOBULATION; HEALTH
HAZARDS: OCCUPATIONAL HAZARDS;
TCNGUE; ZIRCOBI0H; ELEBENTS
BEFEBENCE
Teraoka, H.
1981
Archives or
Environmental Health
36(4) : 155-161;
Teraoka, H.
1981
Archives of
36(4) : 155-165
Teraoka, H.
1981
Archives of
36 (4): 155-165
ro
Ul
oo
(NEXT PAGE)
-------
Tin
7*110-31-5
Sn
AtB 118.69, HP 231.9 C, BP 2507 C, VP 1 mm Kg at 1610 C, 10 II Bg at 1890 C
(CONTINUED)
TISSOE
6822
liver
6823
Liver
68 2U
Lung
EXPOSDRE RODTE
_
ANALYTICAL
BETHOD
ES
ES
-
NOB
OF C
a) 9
b) 2
c) 3
4) 1
e) 1
30
a) 12
b) 2
0 3
d) 1
e) 1
HDHBEB
OF CASES
1) 9
3) 2
:) 3
1) 1
6) 1
30
»> 12
b) 2
3 3
d) 1
e) 1
BABGE
Not given
b) 1.1-3.2 ppm
c| 1.3-1.7 ppm
d) Hot applicable
e) Hot applicable
Dry «t
0.08-0.65 ug/g
Vet wt
a) Not given
b) 3.1-9.6 ppm
c) 3* 7~ 1 00 ppn
d) Not applicable
e) Hot applicable
Dry wt
MEAN
a) 1.1 »or- 0.41 ppm
b) 2.2 ppm
c) 1.5 ppm
d) 0.93 ppm
e) 0.53 ppm
Dry wt
Not given
a) 1.5 +oc- 0.80 ppm
b) 6.3 ppm
c) 36 . 2 ppm
d) 1.7 ppa
e) 1.0 ppm
Dry wt
GEBEBAL IBFORBATIOB
a) Bormal healthy aen
b) Chromium plating workers
c) chcomate refining workers
d) Airplane painter
e) stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AOETA; BONES; HEABT;
INTESTINES; KIDBETS; IIVEB; IBNSS;
ItBPH NODES; PANCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
ALUBINOB; BJKI01; CADBIOS; CALCOTB;
CBBOB1UB; COBALT: COPPEB; IBON; LEAD;
9AGNESIDH; BANGANESE; HETALS;
BOLTBDENOB; NICKEL; PHOSPHOROS;
POTASSIOB; SILICON: SILVER; SODIOS;
SlROSTIOll; TIM; TnASIOB; VASADIOB;
ZINC; BIOACCOBDLATION; HEAITH
HAZARDS; OCCUPATIONAL BA7ACDS;
TONGUE; ZIRCOSIOB; ELE8EBTS
Category 1 (first priority element)
as proposed by International Workshop
and Specimen Banking
Autopsies, Baltimore, BD,
Minneapolis, HN, and Seattle, WA
BJRlLSND; BINNEBOTA; BASHINOTOB ;
AUTOPSIES; LITER; HEASUREBENT
HETHODS; ALOBINaB; AHTIBONT; ARSENIC;
E6BIOR; CkDHIBB; CHSOBI13B; COBALT;
COPPEK; FLDORINB; IEON: LEAD:
BANGiNESE: HERCOBY; BOLIBDE»0»;
NICKEL; BOBIDIOB; SELENIOH; SILVER;
S1ROHTIDB; THALLI1W, TI»; VAHUDIflfl;
ZINC; POPDLATION EtPOSORB
a) Normal healthy aen
b) Chromium plating workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JiPHS; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
ALOBINOB; BARIDB: CADBIOS; CALCIHB;
CBROBIOH; COBALT: COPPER: IRON: LEAD;
BAGNESIOH; BANGANESE; HETALS;
BOLYBDENaB; NICKEL; PHOSPHOROS;
POTASSIOH: SILICON; SILVER; SODIOB ;
STBOHTIOl; TIS; TITANIOB; VANADIUB;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL BA2ARDS;
TONGUE; ZIRCONIBB; ELEBENTS
REFERENCE
Teraoka , H.
1981
Archives of
Environmental
36(1) :155-165
Harrison, S.H
zeisler, R.
1981
EPA 600/S1-81
pp.
Teraoka, H.
1981
Archives of
Environmental
36(0) :155-165
Health
-025, 6
__.
Health
01
(NEXT PAGE)
-------
Tin
71110-31-5
So
At* 118.69,
6825
Ly«ph
node
IIP 231.9 C, BP 2507 C, It 1 » Hg at 1610 c, 10 II Bg at 1890 C
(CONTINUED]
6826
Pancreas
6827
Spleen
EXPOSURE ROUTE
ANALYTICAL
METHOD
ES
BS
BS
...
NUUBBB
OF CASES
a) 3
0) 1
c) 3
ai 1
el 1
5
-
a) 9
b) 2
c) 3
d) 1
e) 1
-
BANGE
a) Not given
b) Hot applicable
c) 5. 2- tOO 9p&
d) Not applicable
e) Not applicable
Dry wt
Sot git en
.
a) Hot given
b) 2.2-2.3 pp.
c) O.J1-2.5 ppi
d) Hot applicable
e) Hot applicable
Dry wt
-
(NEXT
BEAN
a) 9.8 »or- 1.3 ppn
b) 11 pp.
c) 39.1 pp.
d) 5.9 ppn
e| 0.7 pp.
Dry wt
0.43 *or- 0.17 ppm
dry wt
a) O.S5 »or- 0.37 ppo
b) 2.2 pp.
c) 1.6 pp.
4) 0.32 pp.
e) 0.30 pp«
Dry wt
-
PAGE)
GENERAL IHFORHATION
a) Normal healthy sen
b) Chroniui plating worker
c) Chromate refining workers
d) Airplane painter
e) Stone aasoa
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES: ADRENAL
GLANDS; AOKTA; BONES; HEART;
INTESTINES; KIDNEYS; LITEP; LUNGS;
1TBPH NODES: PAHCBEAS; SPLEEN;
STOgACH; THTEOID GLANDS; TBACHZ1;
H.OHITOH; BAKIOH; CADSinS; CAlClnB;
CBEOBItia; COBALT; COPPEB; ISDN; LEAD;
ttJGKESICH; HANGANESE; ItBTALS;
nOLYBDENOH; NICKEL; PHOSPHORUS;
POTASSIUM; SILICON; SILVEE; SODItlB;
SlBOHTIOn; TIN; TITANIOH; VAHADIDH;
ZIHC; BIOACCOI101ATION; HEALTH
HAZAEDS; OCCBPATIOHAL HAZABDS;
TONGOB; ZIBCONItm; ELE»B»TS
Horial tissae
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BODES; HEASI;
INTESTINES; KIDNETS; LITER; L0NGS;
LTflPB NODES; PANCEEAS; SPLEEN;
STONACH; THIEOID GLANDS; THACBEA;
ALODINDn; BABIUN; CADBIUB; CALCIDH;
CHFOHIUn; COBALT; COPPER; IRON; LEAD:
MAGKXSinn; 1HSG182SE; ilETALS;
NOLIBDENOH; NICKEL; PHOSPHORUS:
POTASSIDB; SILICON; SILTER; SODIIJB;
SIRONTIDB; UN; TITANIOH; JANiDITO;
ZINC; BIOACCtJHOLATION: HEALTH
HAZAEDS; OCCOPATIONAL BAZABDS;
TONGUE; ZISCONIUB; ELEMENTS
a) Noraal healthy Men
b) chroiiun plating workers
cj chroiate refining workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNETS; LITER; LUNGS;
LiHPH NODES; PAHCBEAS; SPLEEN:
STOMACH; TRTEOID GLANDS; TRACHEA;
MCKimfl; BIEIDH; CAOHMB; CALCIUI;
CBROHIDH; COBALT; COPPER; IBON; LEAD;
RAGNE5IUH; «ANGAH£SE; HETALS;
80LYBDENUH; NICKEL; PHOSPHORUS;
POTASSIUB;.SILICON; SILTER; SODIUB;
STRONTIUB; TIN; TITANIUH; VANADIUB;
IINC; BIOACCUaULiHON; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZI8CONIUH; ELEHENTS
Teraoka, R.
1981
Archives of
Environmental Health
36(»):155-165
Teraoka. H.
1981
Archives of
Environcental Health
36 (»): 155-165
rO
C^
O
Teraoka, B.
1981
Archives of
Environmental Health
36(»): 155-165
I
-------
Tin
70HO-31-5
Sn
At« 118.69, HP 231.9 C. BP 2507 c, VP 1 »• Hg at 1610 c, 10 mm Bg at 1890 c
(COSTINOED)
TISSUE
6828
Stomach
6829
Thyroid
gland
6830
Tongue
EXPOSURE ROUTE
__.
ANALYTICAL
BETHOD
ES
IS
ES
NOBBER
or OSES
10
«
2
HANGE
Not given
Hot given
Hot given
0.88 -tor- 0.55 ppn
dry »t
0.37 +or- 0.25 ppa
dry »t
O."40 tor- 0.02 ppm
dry »t
(HEX! PAGE)
GENERAL III FOE Bill OH
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES: ADBENAL
GLAHDS; AORTA; BOHES; HEART;
IHTESTIHES; KIDNEYS; LIVER; LONGS;
LYHPH HODES; PAHCBEAS; SPLEEH;
STOBACH; THIBOID GtAHDS; TBACREA;
iLoni»nn; BABIDH; CADHIDD; cAicinn;
CBEOBIOB; COBALT; COPPER; IBOH; LEAD;
KAGHESIOH; HAH6AKESE; KETALS;
HOLIBDEHDB: NICKEL; PHOSPHOBOS;
POTASSIOH; SILICOH; SILVER; SODIOH;
S1ROHTIOB; TIB; TITABIOB; VAVADIOK;
ZHC; BIOACCOBDLAIIOH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOHGDE; ZIRCONIOB; ELEBEMTS
Hortal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLASDS; AORTA; BOHES; BSARI:
IBTBSTIHES; KIDHEIS; LIVER; LOHGS;
IIPPH HODES; PAHCREAS; SPLEEH;-
STOMACH; THXROID GLANDS; TRACHEA;
ALDNIHUB; BARIOB; CADBIOH; CALCIOB;
CHROBIOB; COBALT; COPPER; IROH; LEAD;
nAGHESiOl; HANSAHESE; HETALS;
BOLIBDENOB; NICKEL; PHOSPHORUS;
POTASSI08; SILICOH; SILTEB; SODHJB;
STBOHTIOB; TIH; TITAHIOB; VAHADIOB;
ZIHC; BIOACCnflBLATIOH; HEALTH
HAZARDS; OCCOPATIOHAL HAZARDS;
TOHGOE; ZIRCOHIOB; ELE8EHTS
Hornal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLAHDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVES; LONGS;
LYBPH HODES; PAHCBEAS; SPLEEH;
STOHACH; THYROID GLANDS; TRACHEA;
ALOBINUB; BABIDB; CADBIUB: CALCIOB;
CBBOBIDH; COBALT; COPPER; IROH; LEAD;
BAGNESIOD; HANGANERE; BETALS;
BOLYBDEHOH; HICKEL; PHOSPHOBOS;
POTASSIOB; SILICOH; SILVER; SODIOB;
SIROHTIUH; TIH; TITAHIOB; TANADIUB;
ZIHC; BIOACCOHOLATIOH; HEALTH
HAZARDS; OCCOPATIOHAL HAZARDS;
TONGUE; ZIBCOHIUB; ELEBEHTS
Teraoka, E.
1981
Archives of
Environmental Health
36(»):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(»):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
-------
Tin
7HHO-31-5
Sn
AtW 118.69, BP 231.9 C. BP 2507 C, VP t •> Hg at 1610 C, 10 IB Bg at 1890 C
(CONTINUED)
6831
Trachea
EXPOSURE ROOTE
LYTICAL
ETBOD
NOHEER
OF CASES
2
BINGE
Hot given
HE1N
0.72 »or- 0.54 pp»
dry wt
GENERAL INFORHATION
Normal tissue
Autopsies
JAPAN; ADULTS; AOTOPSIES; ADRENAL
GLANDS; AORTA: BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNSS;
1YHPH NODES; PANCREAS; SPLEEN;
STOBACH; THIROID GLANDS; TBACREA;
ALOHINUH; BABIUB; CADHIOfl; CALCIUB;
CBROHIOB: COBALT; COPPEE; IRON; LEAD;
BAGNESIDB; MANGANESE; BETALS:
HOLYBDENDH; NICKEL; PBOSPHORDS;
POTASSIUM; SILICON; SILVER; SODIDB ;
STROSTIUH; TIB; TITiUltHI; V»»iDin»;
ZINC; BIOACCOHOLATION; HEALTH
HAZARDS; OCCVPATIONAL HAZARDS;
TOHGHE; ZIRCOHIOB; ELEIIENTS
REFERENCE
Teraolcav R.
1981
Archives of
36(1) :155-165
litanim
7H10-32-6
Ti
At« 17.90, HP 1677 C. BP 3277 C, VP 1 » Hq at 2180 C, 10 •• Bg at 2480 C
6832
Adrenal
gland
6833
Aorta
HPOSOBE ROUTE
ANALYTICAL
HETHOD
NUDBER
OF CASES
Hot given
Not given
1.0 +or- 0.69 ppm dry
wt
0.45 tor- 0.29 pp>
dry wt
GENERAL INFOBBATION
Normal tissue
Autopsies
Japan
JAPAN; ADULTS: AUTOPSIES; ADRENAL
GLANDS; AOBTA: BONES; HEART;
INTESTINES: KIDNEYS; LIVEB; LONGS:
LItlPH NODES; PANCBEAS; SPLEEN;
STOMACH; TRTROID GLANDS; TBACHEA;
ALUBINDH; BABIOH; CADHIOK; CALCIOfl:
CBEOBIDB; COBALT; COPPER; IRON; LEAD;
RAGNESIDH; MANGANESE; NETALS;
aOLTBDENOH; NICKEL; PROSPBOROS;
PCTASSigH; SILICOK; SILVER; SODIOd;
STBONTIDH; TIN; TITANIDS; VANADIOH:
ZINC; BIOACCOBBLATIOtl; HEALTH
HAZARDS; OCCUPATIONAL HiZABDS;
TONGUE; ZIBCONIOB; ELEBENTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEART;
INTESTIMES; KIDNEYS; LIVES; LONGS;
LYBPR NODES; PANCREAS; SPLEEN;
STOMACH; THIKOIO GLANDS; TKlCHEi;
ALUfllNun; BABIOfl; CADHIQH; CALCIT1H;
CHROBI1JH: COBALT; COPPEB; IRON; LEAD;
HAGNESIDH; HAN6ANESE; HETALS;
BOLIBDENUM; NICKEL; PHOSPHORUS;
POT1SSIDH; SILICON; SILVER: SODTUB;
STROHTIOH; TIN! TITANIDH; VANADIOB:
ZINC; BIOACCOHDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TON GO I; liaCOmoB; ELEBS1I1S
Teraokav H.
1981
Archives of
Environmental Health
36(») : 155-165
Teraoka, R.
1981
Archives of
Environaental Health
36(«):'5S-165
(NEXT PAGE)
Kl
-------
Titanium
71HIO-32-6
Ti
»t« 17.90, HP 1677 c, BP 3277 C, YP 1 H Hg at 2180 C, 10 mm Bq at 2480 C
(CONTINUED)
TISSDB
6834
Bone
6835
Heart
6836
Intestine
EXPOSURE ROUTE
ANALYTICAL
BETHOD
ES
ES
ES
NOB BEE
OF CASES
5
a) 8
b) 2
c) 3
d) 1
e) 1
10
RANGE
Hot given
a) Hot given
b) 1. 1-1.6 ppn
c) 0.27-1.5 PP»
d) Hot applicable
e) Not applicable
Dry wt
Hot given
[HE XT
BEAN
<4.0 ppi dry
a) 0.23 *or-
b) 1.4 pp«
c) 0.75 ppa
d) 0.92 ppn
e) 2.5 pp»
Dry »t
0.51 »or- 0.2
dry »t
PAGE)
0.06 ppn
GEIEBAL ISFOBHATION
Hornal tissue
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
IHTESTIHES; KIDNEYS; IIVER; LONGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOHACH: THYROID GLAHDS; TSACBEA;
AinaiNnn; BiiiiOH: cAoninn: CALCIOB;
CBBOnlDB; COBALT; COPPER; IRON; LEAD;
IIAGNESIDH; 8ANGANESE; BETALS;
BOLIBDEHOI1; SICKEL! PHOSPHOSdS;
POTASSIOR; SILICON; SILVER; SODIM;
SIRONTlna; IIS; TITANlnn; VAHADIOTI;
ZINC; BIOACCOaOLAHON; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCOSItJH; ELEBENTS
a) Nocnal health; aen
b) chroaiua plating vorkers
c) Chronate refining workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BOBES; HEART;
INTESTINES; KIDNEYS; LIVED; LBHGS;
LYBPH NODZS; PANCEEAS; SPL«8;
STOBACH; THYROID GLANDS: TRACHEA;
ALDBINDH; BARIUB; CADBIOH; CAICIOB;
CHBOBIDfl; COBALT; COPPER; IBON; LEAD;
BAGNESIDIl; KAN8ANESE; UETALS;
BOLTBDEBUH; NICKEL; PHOSPHORUS;
POTASSIOH; SILICON; SILVER; SODIDB;
STRONTIDB; TIN; TITANIOB; VANADIOB;
ZISC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZISCONIDB; ELEBENTS
Noraal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS: LIVER; LUSGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOHACH; THYROID GLANDS; TRACHEA:
ALORIHUB; BARIDB; CADBIUB; CALCIOB;
CHROHIUS; COBALT; COPPER; IRON; LEAD;
BASNESIUH; BARGANESE; BETALS;
DOLYBDENDB; NICKEL: PHOSPHORUS:
POTASSIOB; SILICON; SILVER: SODIDB;
SHROHTIUB; TIN; TITASIUB; VAKADIDH;
ZINC; BIOACCUBULATIOH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIHH; ELEflENTS
teraoka* H.
1981
Archives of
Environnental Health
36(»):155-165
Teraoka, H.
1981
Archives of
Environaental Health
36 (4): 155-165
ON
U)
Teraoka, H.
1981
Archives of
Environnental Health
36(»):155-165
-------
litaniui
7*40-32-6
Ti
its 47.90,
6837
Kidney
MP 1677 C, BP 3277 C, »P 1 •> Hg at 2160 C, 10 mm Hg at 2480 C
(CONTINUED)
6838
LiTer
6839
lung
EXPOSURE ROOTE
ANALYTICAL
BET HOD
ES
ES
_
ES
NUMBER
OF CASES
a) 8
b) 2
C) 3
d) 1
e) 1
a) 9
b) 2
O 3
»\ 1
**J 1
e) 1
a) 12
b) 2
c) 3
4) 1
e) 1
BAHGE
a) Not given
b) 0.20-0.411 ppa
c) 0.24-0.95 pp.
d) Not applicable
e) Not applicable
Dry wt
— ._
a) Hot given
b) 0.26-0.74 pp.
o) 0.46-1.7 ppa
e) Hot applicable
Dry vt
-
_
a) Not given
b) 9.2-22 pp.
c) 23-210 ppB
d) Not applicable
e) Not applicable
Dry »t
DEAN
a) 0.27 +or- 0.03 pp.
b) 0.32 pp.
c) 0.58 ppa
d) 4.1 ppB
e) 1.7 pp.
Dry wt
a) 0.37 *or- 0. 18 ppu
b) 0.50 fpm
c) .93 pp.
e) 12 ppB
Dry wt
a) 33 + or- 32 ppa
b) 15.6 pp.
c) 89 ppB
d) 920 pp.
e) 110 ppa
Dry vt
GENERAL INFORMATION
a) Hor«al healthy Ben
b) CnroaioB plating workers
c) chroaate refining workers
d) Airplane painter
e) stone Hasan
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADEEKJL
GltNDS; AOBTA; BORES; HEART;
IBTESTISES; KIDNEYS; LIVES ; LONGS;
LTBPR NODES; PA11CBE1S; SPLEEH;
STOMACH; THIBOID GLANDS; TRiCBEA;
ALOHIKOI!; BASIIU1; ClDnlD!); C11CIDI);
cHRoniun; COBALT; COPPER; IBON; LEAD;
DASNESIOH; IIANGAHESE; BETALS;
SOIIBDENOH; NICKEL: PHOSPHOROS;
POTASSHJB; SILICON; SILTEH: SODTDa;
STBONTIOH; TIN; TITANIDH; TANADIOH;
2I»C; BIOACCOHOLATIOH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIOB; ELEMENTS
a) Nor.al healthy nen
b) chroilu. plating workers
c) chronate refining workers
e) stone aason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES: KIDNETS; LI7ER; LONGS;
LIHPH NODES; PANCREAS; SPLEEN;
STOMACH; THIHOID GLANDS; TRACHEA;
ALUHIRETH; BARIUB; CADHIITII; CALCIOR;
CHKOniUH; COBALT; COPPER; IRON; LEAD;
HAGNKSIUtl; HANGANESE; HETALS;
BOlIBDENUn; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON; SILVER; SODIUB:
STSONTIUH; TIN; TITAHIOB; ?»H»Dlna;
ZIBC; BIOiCCDilDLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOKGUE; ZIRCOHIUB; ELEMENTS
...
a) Norial healthy Ben
b) Chro.iu. plating workers
d) Airplane painter
e) stone Bason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BEART;
INTESTINES; KID NETS; LITER; LUNGS;
LTRPH NODES; PAHCBEaS; SPLEEN;
STOHACH; TBIROID GLANDS; TRACHEA;
ALONIRUB; BARIUM; CADMIUM; CALCIUM;
CBSOMIUH; COBALT; COPPER; IRON; LEAD;
MAGIESIUM; MANGANESE; METALS;
MOLYBDENUM; NICKEL: PHOSPHORUS;
POTASSIUM; SILICON; SILTER ; SODIUM;
STRONTIUM: TIN; TITANIUM; VANADIUM;
ZIBC; BIOACCUMULATXON; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS-
TONGUE: ZIRCONIUM; ELEMENTS
i . ,,
EEPEREKCE
Teraoka. H.
1981
Archives of
36(4): 155-165
Teraoka, H.
1981
Archives of
36(4) : 155-165
Teraoka , H.
1981
Environmental Health
36(»): 155-165
N3
O\
(NEXT PAGE)
-------
Titanium
KHlO-32-6
Ti
AtB HI. 90, tlf 1677 C, EP 3277 c, VP 1 n Hg at 2180 C, 10 •• Hg at 2480 C
(CONTINUED)
TISSUE
6810
Lyiph
node
6841
Pancreas
6802
Spleen
EXPOSURE ROUTE
ANALYTICAL
HETHOD
ES
ES
ES
» on BEE
OF CASES
a) 3
b) 1
c) 3
d) 1
e> 1
5
a) 9
b) 2
c) 3
d) 1
e) 1
BAHGE
a) Hot given
b) Vat applicable
c) 29-95 ppi
d) Hat applicable
e) Hat applicable
Dry wt
Hot given
a) Hat given
b) 0. 73-2.0 ppi
c) 0.65-2.9 ppi
d) Hot applicable
e) Hot applicable
Dry vt
HE1H
a) 150 +or- 60 ppa
b) 36 ppi c) 52 ppi
d) 2800 ppi
e) 330 ppi
Dry wt
0.82 +or- 0.27 ppm
dry »t
a) 0.98 +or- 0.89 ppu
b) 1.36 ppi
c) 1.6 ppa
d) 7.1 pp.
e) 33 ppi
Dry wt
(NEXT PAGE)
GENERAL INPOEHATIOH
a) normal healthy len
b) chroiiai plating worker
c) cbroiate refining workers
d) Airplane painter
e) Stone lason
Autopsies
3apai>
JAPAH; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LITER; LONGS;
LIBPH HODES; PA DC BE AS; SPLEEN;
STOBACB; THIBOID G14SDS; TRACHEA;
ALOBINUH; BABIUB; C1CBIUB; CALCIUB;
CHROSIUB; COBALT; COPPER; IBOH; LEAD;
BAGHESIOn; BANGABBSE; BETAIS;
BC1TBDESIJB; NICKEL; PHOSPHOBDS;
POTASSIOB; SILICOB; SILVER; SODIOn;
STBOHTI08; TIH; TITASIOn; VABADIOB;
ZIBC; BIOACCOBOLATIOH; HEALTH
HAZARDS; OCCUPATIONAL BAZABDS;
TOHSDE; ZIBCOHIOB; ELEBIHTS
Norial tissue
Autopsies
Japan
JAPAH; ADULTS; AOTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEABT;
IHTESTIHES; KIDHEIS; LIVES; LOHSS;
LIMPH KODES; PANCREAS; SPLEEN;
STOHACH; THTBOID GLANDS; TRACHEA;
AIDBISDB; BARIOH; CADHIOH; CALCIOB;
CHBOnlllH; COBALT; COPPER; IBOH; LEAD;
BAGNESIOB; BANGAKESE; BETALS;
BCLIBDENOH; HICKEL; PHOSPBOBOS;
BOTASsins; snicosj SILVER; sooins;
STBONTIDB; TIN; TITiSIOl!: VAHADIOH;
ZINC; BIOACCOBULATION; REALTB
HAZARDS; OCCUPATIONAL HAZARDS;
TONGOE; ZIRCOHIOB; ELEHEHTS
a) Norial healthy ien
b) chcoiim plating workers
c) Chroiate refining workers
d) Airplane painter
e) Stone lason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADKEHAL
GLANDS; AOBTA; BONES; HEABT;
INTESTINES; KIDNETS; LIVES; LONGS;
LYMPH NODES; PANCEEAS; SPLEEN;
STOHACH; THIBOID GLANDS! TRACHEA;
A10BTNOB; BABIOB; CADBItJB; CALCIUB;
CBROHIDB; COBALT; COPPER; IRON; LEAD;
8AGNESIOB; BANGANESE; BETALS;
BOLIBDEN0B; NICKEL: PHOSPHORUS;
POTASSIDB; SILICON; SILVER; SODIUH;
STBONnua; TIH; TITANIOB; VAHADIOH;
ZINC; BIOACCUBBLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUB; ELEBEHTS
Teraoka, H.
1981
Archives of
Environmental Health
36(») :155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(1) :155-165
NJ
ON
Ln
Teraoka, H.
1981
Archives of
Environmental Health
36(») : 155-165
-------
Titaniui
7440-32-6
ti
AtW 47.90, IIP 1677 C, BP 3277 c, VP 1 •• Hg at 2180 c, 10 •• Hg at 2480 C
(CONTINUED)
TISSUE
6843
Stomach
6844
Thyroid
gland
6845
Tongue
EXPOSURE ROUTE
ANALYTICAL
HETHOD
ES
ES
ES
NUBBEB
OF CASES
10
4
2
BINGE
Not given
Hot given
Hot given
BEAN
0.51 tar- 0.29 ppu
dry »t
0.37 tor- 0.22 ppn
dry lit
0.39 tor- 0.25 pp«
dry »t
GENERAL INFORNATI08
Nonal tissue
Autopsies
Japan
JAPAN: ADULTS; iOTOPSIES; »DfiEN»L
GUNDS; tOBTA; BONES; HEABT;
IHTESTIIIES; KIDHEYS; 1I7EE i LDH6S:
1YBPH BODES: P»»CBBJS; SPIIEHj
STOBACH; THYBOID 6LJHDS; TBACHEA;
AinniHDH; BABioa; CADnloil; OI.CIOB;
cBBoainn: COBALT; COPPEB; IBO»; LEAD;
BAGSESinn; BANGiHESE; flETAlS;
nOLYBDEHUH ; HICSE1; PHOSPBCBDS;
pOTAssina; SILICON: SILVEB; SODIDB:
STBOHTIDB: TIB; TITANIOB; VAHADIOT:
ZIHC; BIOACCDBOLATIOH; HEALTH
HAZARDS; OCCUPATIONAL BAZABOS ;
TOHGtlE; ZIBCOHIUB; ELEBEHTS
ftornal tissue
Autopsies
JAPAN; A DOLTS; AUTOPSIES; ADBEHAL
GLANDS; AOBTA; BONES; BEAST;
INTESTINES; KIDNEYS; LITZB ; LUNGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACH: THYROID GLANDS; TBACHEA;
ALOHIHOK; BABIVB; CADBIOB; CAICIOB ;
CBBOBIBB; COBALT; COPPEK; IBON; LEAD;
BAGNESIDB; BANSANESE; BETAtS;
BOLYBDENDfl; NICKEL; PHOSPHOBDS;
POTASSIUB; SILICON; SILVEB; 30DIOB;
STBONTIOB; TIN; TITANIUB; »AllADinB;
ZINC; BIOACCOHOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCOHIOB; ELEBENTS
Norial tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEABT;
INTESTINES; KIDNEYS; LIVER; 1BNGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
ALDHINUn; BAEION; CADBIDB; CALCIOB;
CHBOHIUB; COBALT; COPPER; IRON; LEAD;
BAGNESIOB: HANGANESE; BETAIS;
BOLYBDENOB; NICKEL; PHOSPHORUS;
POTASSIUB; SItlCON: SILVER; SODIUB;
STRONTIUB; TIN; TITANIOB; 1ANADIUB;
ZIBC; BIOtCCUHOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGOE; ZIBCONIDB; ELEMENTS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(4); 155-165
Teraoka, H.
1981
Archives of
36(4):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
(NEXT PAGE)
NJ
-------
litaniUB
7100-32-6
Ti
AtW U7.90, «P 1677 C, 8P 3277 C, VP 1 » Hg at 2180 C, 10 •• Hg at 2480 C
(CONTINUED)
TISSUE
68D6
Trachea
EXPOSURE ROUTE
ANALYTICAL
BETBOD
ES
II OH BEE
OF CASES
2
RANGE
Not given
BEAM
0.38 +or- 0.23 ppia
dry wt
GENERAL INFORBATIOB
Normal tissue
Autopsies
JAPAN: ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; BEART;
INTESTINES; KIDNEYS; LITER; LUNGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACB; TBIROID GLANDS; TBJCBEI;
ALDBINOH; BAEIUB; CADBIUB; CAICIOS;
CBROBIUfl; COBALT; COPPER; IRON; LEAD;
BAGNESIOB; BANGANESE; BETALS:
BOLYBDEBUB; NICKEL; PHOSPBCRIJS;
POTASSICB; SILICON; SILVER; SODIUfl ;
STRONTIOK; TIB; TITANIUH; VANADIUB;
ZINC; BIOACCOBULATIOB; HEALTB
BJZARDS; OCCUPATIONAL BAZARDS;
TONGUE; ZIRCONIUM; ELEBENTS
REFERENCE
Teraoka, B.
1981
Archives of
36(K): 155-165
Toluene (8 CI)
Benzene, aethyl- (9 CI)
108-88-3
C7-B8
B» 92.13, BP -95 to -94.5 C, BP 110.6 C, VP 36.7 u Hg at 30 C
TISSUE
68U7
Blood
6848
whole
6849
Breath
EIPOSORE ROUTE
Inhalation
Inhalation
ANALYTICAL
BETBOD
GC
GC
GC/BS
HOB BEE
OF CASES
a) 70
b) 11
C) 10
4) 6
a) 7
t) »
C() 11
h) 8
i) 5
.. .
20
28
BANGS
a) 141-3622 ug/1
b) 526-4530 ug/1
c) 181-415 ug/L
d) 72-214 ug/1
e) 336-742 ug/1
f) 134-824 ug/1
g) 350-763 ug/1
h) 30-349 ug/1
i) 30-145 ug/1
755.3-21.9 ug/1
4-20 ng/1
BEAU
a) 1591 ug/1
b) 1615 ug/1
c) 299 ug/1
d) 138 ug/1
e) 587 ug/1
£) 433 ug/1
g) 545 ug/1
h) 134 ug/1
i) 80 ug/1
Not applicable
10 ng/1
GENERAL INFORBATION
a) 129 il/sg n. Bean concentration
in room air, (sane for b-i)
b) 109 ul/sg ID
c) 19 «l/sq
o) 13 nl/sg
e) 23 il/sq
f) 18 «l/sq
g) 21 ml/sq
h) 3 ml/sq m
i) 2 »l/sg >
Correlation between exposure and
blood levels
Printing shop workers, Geraany
INDUSTRIAL SOLVENTS; INDUSTRIAL
CHEBICAiS: GEEBANY; ADULTS; BLOOD;
INDUSTRIAL AREAS; INDUSTRIAL
ATBOSPBERES; INHALATION; OCCUPATIONAL
HAZARDS; PRINTING INDUSTRY
0 and 20 hr after exposure to 200 ppm
10 ug/1
Ranqe of Means
INDUSTRIAL CHEBICALS; ADULTS; BLOOD;
URINE; TOLUENE; ISBALATION;
BETABOLITES; GEHBJNY
Estimated froa graph
Healthy 16-60 yr olds, nons&okers.
Rigid protocol 14 days before and
during study to Bininize nunber and
anount of exogenous constituents.
ADULTS; BREATB; ALCOBOLS; CBL08INE
ORGANIC COBPOUSDS; CHLOROBENZENES
Angere
Behlin
1981
I ate rn
of Occ
Enviro
48:137
naivod
1981
Brit is
Indust
Krotos
Gabrie
o'Neil
Claudi
1977
Journa
Chroia
15:239
(NEXT PAGE)
-------
•toluene (S CI)
Benzene, methyl- (9 CI)
108-88-3
C7-H8
. /-do
IK 92.13, HP -95 to -91.5 C, BP 110.6 C, VP 36.7 •• Hg at 30 C
(CONTINUED)
TISSDE
6850
Orioe
EXPOSURE BOOTS
Inhalation
ANALYTICAL
METHOD
GC
lUKBEB
Of CASES
a) 19
b) 19
c) 18
1) 19
e) 18
BAHGE
a) 4.208-0.680 g/1
b) 1.603-0.130 »g/l
c) 0.599-<0.2 »g/l
d) 39.590-40.968 ag/1
e) 3.483-6.900 «g/l
a) Not applicable
b) Not applicable
c) Hot applicable
d) Not applicable
e) Not applicable
GENEBAL INFORMATION
a) Hippuric acid, 0 and 44 hr.
Preexposure level 0.823 g/1
t) o-cresol, 0 and 44 hr.
Preexposure level 0.159 mg/1
c) a-Cresol, 4 and 44 hr. Preexposure
level <0.2 ag/1
d) p-Cresol, 0 and 4 hr. Preexposure
level 31.206 Bg/1
e) Phenol, 0 and 20 hr. Preexposure
level 4.869 Bg/1
Toluene metabolites, after 4 hr
exposure to 200 ppn in air.
INDUSTRIAL CHE1ICALS; ADULTS; BLOOD;
OBINE; TOLUENE; INHALATION;
HETABOLITES; GERMANY
Woiwode, K.
Drysch, 1C.
1981
British Journal of
Industrial Medicine
38: 194-197
Toluene, o-nitro- (8 CI)
Eenzene, 1-«ethyl-2-nitro- (9 CI)
88-72-2
C7-H7-N-02
HW 137.1, BP -4.1 C, BP 222.3 C, VP 1 » Hg at 50 C
- TISSUE
Breath
EX PCS QBE POOTE
ANALYTICAL
METHOD
_
NUMBER
OF CASES
BANGE
BEAN
GENEBAL INFORMATION
Healthy 18-60 yr olds, nonsaokers.
during study to •iniaize nuaber and
ADOLTS; BREATH; ALCOHOLS; CHLOPINE
OBGANIC COBPOONOS; CHLOBOB EHZEN ES
REFEEENCE
Gabriel, G.
O'Neill, H.
1977
chrOBatographic Science
15:239-244
K3
ON
00
Tungsten
7440-33-7
>
At» 183.85, HP 3410 C, BP 5900 C. TP 1 BB Hg at 3980 C, 10 BB Ug at 4490 C
TISSUE
6852
Hair
EXPOSURE ROOTE
ANALYTICAL
BETHOD
HA
NOHBEB
OF CASES
51
BADGE
0.005-0.037 ug/g
HEAD
Not given
GENERAL IHFOBHATION
_.
Range of Beans, estiBated froB graph
Aswan, El Kharga, Assuit, Cairo, and
EGYPT; HAIB; NAILS; ANTlnONY;
CADBIOB; CESIOB; CHROBIOB; COBALT;
SCANDIUB; SELE8IUB; SILVER; TUNGSTEN;
ZINC; DRINKING VATER; POPULATION
EXPO.SOBE; SOILS; UBBAN AREAS
REFERENCE
Kasperek, K.
lyengar, G. V.
Feinendegen, L.E.
Bahfouz, B.
1982
Science of the Total
(HEIT PAGE)
-------
Tungsten
74SO-33-7
«
AtV 183.85, ft 3110 C, BP 5900 c, VP 1 «• Hg at 3980 C, 10 » Hg at "4190 C
(CONTINUED)
6853
Nail
EXPOSURE ROUTE
ANALYTICAL
HETHOD
NDHBEB
OF C1SES
0.008-0.036 ug/g
Not given
GENERAL INFOBHATION
Range of means, estimated from graph
Aswan, EL Kharga, Assait, Cairo, and
Alexandria, Egypt
EGYPT; BilB: NAILS; ANTHONY;
CADHIUH; CESION; CHBOHIUH; COBALT;
IRON; BANGANESE; flETALS; BOLYBDENUH;
SCANDIUB; SELENIDB; SHVEB ; TUNGSTEN;
ZIHC; DRINKING (TATEB; POPULATION
EXPOSURE; SOILS: URBAN AREAS
Kaspecek, K.
lyengar, G.V.
Feinendegea, L.E.
Hashish, S.
Hahfouz, ».
1982
Science of the Total
Environment 22:119-168
Valeric acid, ethyl ester (8 CI)
Pentanoic acid, ethyl ester (9 CI)
539-82-2
C7-H11-02
Hff 130. 18, DP 115-116 C
6854
Breath
EXPOSURE BOOTE
ANALYTICAL
flETHOD
GC/HS
son BBS
OF CASES
28
BINGE
0.06-0.5 ng/1
DEAN
0.19 ng/1
GENERAL INFORMATION
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol \u days before and
during study to vinimize nunber. and
anount of exogenous constituents.
ACOLTS; BREATH; ALCOHOLS; CHLORINE
OBGANIC COHPOOBDS; CHLOROBENZEBES
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
claudio. n. P. A.
1977
Journal of
ChroBatographic Science
15:239-211
ho
o~-
VO
vanadiua
70QO-62-2
V
AtK 50.9111, HP 1917 C, BP 3000 c, VP 1 BB Hg at 2290 C, 10 •• Hg at 2570 C
«855
Adrenal
gland
EXPOSURE ROUTE
ANALYTICAL
HETHOD
NOB BEE
OF CASES
7
RANGE
Sot given
MEAN
<0.« pprn dry ut
GESEPAL INFORHATION
Normal tissue
Autopsies
Japan
JAEAB; ADULTS; AUTOPSIES; ADRENAL
GIANDS; AORTA: BONES; HEAPT;
INTESTINES; KIDNEYS; LIVHR; LONGS;
LYNPB NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
AllWISOa; BARIUB; CSDHH7H; CAICI&9;
CHROHInn; COBALT: COPPER; IRON; LEAD;
KAGNESIOH; KANGANESE; BETALS:
BOLYBDEBOH; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON: SILVER; SODIUM;
STRONTIDB; TIN; TITANIOH; VANADIDB;
ZINC; BIOACCOHULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGUE; ZlfCONIUB; ELEBENTS
(KEXT PAGE)
Teraoka, H.
1981
Archives of
Environmental Health
36(1) : 155-165
-------
vanadium
7HHO-62-2
V
At« 50.9HHI, BP 1917 C, BP 3000 C, VP 1 mm Hg at 2290 C, 10 mm Hg at 2570 C
(CONTINUED)
TISSUE
6856
Aorta
6857
Blood
6858
Bone
6859
Heart
EXPOSURE ROUTE
ANALYTICAL
HETHOD
ES
NA
ES
ES
NUHBBR
OF CASES
7
5
a) 8
b) 2
0 3
e) 1
8ANGE
Not given
a) 0.024-0.939 ng/»l
b) 0. 016-0. 139 ag/ml
Not given
a) Not given
b) 0.62-0.70 ppm
c) 0.90-1.6 ppm
e) Not applicable
Dry «t
BEAN
1.7 tor- 0.67 ppm dry
wt
a) Not given
b) Not given
19 +or- 3.0 ppm dry
wt
a) <0.4 ppm
b) 0.66 ppm
c) 1.2 ppm
e) 0.76 ppm
Dry wt
GENERAL INFORBATION
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOHACH; THYROID GLANDS; TRACHEA;
BLDHINDB; BARI0B: CADBIUM; CALCIUB;
CHROBIUS; COBALT; COPPER; IHON ; LEAD;
BAGNESIOtl; BANGANESE; BETALS;
BOLYBDENUB; NICKEL; PHOSPHORUS;
POTASSIOH; SILICON; SILVER; SODIUH ;
S1ROSTIHB; TIN; TITANIUB; VANADIUB;
ZINC; BIOACCU8ULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUB: ELEBENTS
a) Ben
b) women
Healthy subjects
BELGIDH; BLOOD; BETALS; VANADIUB
Normal tissue
Autopsies
Japan
JAPAN; ADDLTS: AUTOPSIES; ADEENAL
GLANDS; AORTA; BONES; BEAST:
INTESTINES: KIDNEYS; LIVER; LDNSS ;
LIBPH NODES: PANCREAS: SPLEEN;
STOHACH; THYROID GLANDS; TRACHEA;
ALOHINOB; BARIUH; CADHID1; CALCIUS:
CEROBIUH; COBALT; COPPER; IRON; LEAD;
HAGNESItJB; BANGANESE; BETALS;
BOLYBDENUB; NICKEL; PHOSPHORUS;
PCTAS3IUB; SILICON; SILVER; SODIUH;
SISONTIUB: TIN; TITANIUB; VANADIUB;
ZINC; BIOACCOBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIOB; ELEBENTS
a) Normal healthy men
b) Chromium plating workers
c) ChroEate refining workers
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA: BONES; HEART;
INTESTINES; KIDNEYS; LIVES; LUNGS;
IYBPH NODES; PANCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
ALOHINUn; BASIUH; CADBIUS; CALCIUM;
CHBOBIUB; COBALT; COPPER; IBON; LEAD;
(IAGNESIUB; HANGANESE; METALS;
BOLYBDENUH; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON; SILVEB; SODIOT ;
STBONTIUH; UN; TITANIUfl; VANADIUH ;
ZINC; BIOACCOBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOHSriT ZIBCOHTUB; ELEBENTS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36(») :155-165
Cornells, R.
versieck, J.
1961
Lancet 2(8256) :1179
Teraoka, H.
1981
Archives of
Environmental Health
36(») : 155-165
Teraoka, H.
1981
Archives of
36 (»): 155-165
ho
^-4
o
(NEXT PAGE)
-------
Vanadium
7110-62-2
V
AtV 50.9H1I4, up 1917 c. BP 3000 C, VP 1 •• Hg at 2290 C, 10 •• Hg at 2570 C
(CONTINUED)
I TISSUE
1
6860
Intestine
6861
Kidney
6862
Liter
EXPOSURE BOUTE
ANALYTICAL
BETHOD
ES
ES
IS
HtJBBEB
OF CASES
to
a) 8
b) 2
c) 3
d) 1
e) 1
a) 9
b) 2
c) 3
dl 1
uj <
e) 1
BADGE
Nat given
a) Hot given
b) 0. 72- 1.1 ppm
c) 0.82-1.5 ppm
d) Hot applicable
e) Hot applicable
Dry wt
a) Hot given
b) <0.4-1.3 ppm
c) 1.7-2.0 ppm
e) Not applicable
Dry wt
BEAN
0.49 *or- 0.21 ppm
dry vt
a) 0.67 +or- 0.35 ppm
b) 0.91 pp«
c) 1.24 pp«
d) 1.7 ppm
e) 0.81 ppn
Dry wt
a) 0.37 +or- 0.08 ppm
b) Not given
c) 1.9 ppn
e) 0.81 ppm
Dry wt
GENERAL INFOEBATION
_
Nornal tissue
Autopsies
Japan
JAPAN; IDOLTS; AUTOPSIES; ADRENAL
GIANDS; AOBTA; BONES; HEABT;
INTESTINES; KIDNEYS; LIVES; LONGS;
LYBPH BODES; PASCR1AS; SPLSSS ;
STOBJCfi; THYBOID GLANDS; TBJCHEA;
ALOHINOH; BARI01; CADBIOB; CALCIOH;
CHBOBIDB; COBALT; COPPEB; IHON; LEAD;
BASNESlnn; BANSANESE; BETALS;
BOLIBDENUB; NICKEL; PHOSPHOBtJS;
POTASSIUB; SILICON; SILVEB ; SODIOB ;
SIBONTIDB; TIN; TITANIOB; VADADItia;
ZIHC; BIOACCOBULATION; HEALTH
HAZABDS; OCCOPATIONAL HAZABDS;
TONGDE; ZIBCONIOB; ELEBENTS
a) Normal healthy men
b) chromium plating workers
c) chronate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBEHAL
GIANDS; AOBTA; BONES; HEABT;
INTESTINES; KIDSEYS; LIVEB; LONGS;
LTflPH NODES; PANCBEAS; SPLEEN;
STOBACH; THIBOID GLANDS; TRACHEA;
ALOBINUB; BABIUB; CADHI01; CALCIUB ;
CHBOBIDB; COBALT; COPPEB; IBON; LEAD;
flAGNESIOfl; BANGANESE; BETALS;
BOLYBDESUB; NICKEL; PHOSPHOBOS;
POTASSIUB; SILICON; SILVEB; SODIU9 ;
STRONTTUH; TIN; TITA»It»; 'MtABUJfl;
ZINC; BIOACCOBOLATIOS; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TONGUE; ZIRCONIOfl; ELEBENTS
a) Normal healthy nen
b) Chromium plating workers
c) Chromate refining workers
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GIASDS; A08TA; BONES; HEUBT;
INTESTINES; KIDNEYS; LIVER; LUNGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACH; THYBOID GLANDS: TRACHEA;
ALUBINUB; BARIUB; CADHIDB; CALCIUB;
CHBOBIUB; COBALT; COPPEB; IBON; LEAD;
HJGNESIDH; BANGANESE; flETAlS;
BOLYBDENUB; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON: SILVER; SODIUB ;
STRONTIUB; TIN; TITANIDB; VANADIUB;
ZINC; BIOACCUBOLATION; HEALTH
HAZARBS; OCCDPATIONJI HAZABDS;
TONGUE: ZIRCONIUB; ELEBENTS
REFERENCE |
1
Teraoka, B.
1981
Archives of
Environmental Health
36(4) : 155-165
Teraoka, H.
1981
Archives of
KnvironmeDtal Health
36(4): 155-165
Teraoka, H.
1981
Archives of
36(4): 155-165
(NEXT PAGE)
-------
Vanadiun
7440-62-2
At» 50.9414, HP 1917 C. BP 3000 C, VP 1 » flg at 2290 c, 10 mi Hg at 2570 C
(CONTINUED)
TISSDE
6B63
liver
6864
Lung
$865
Lyaph
node
EXPOSURE ROOTB
ANALYTICAL
KETBOD
IS
ES
NUB BEE
OF CASES
30
a| 12
b) 2
c) 3
d) 1
e) 1
i) 3
b) 1
c) 3
d) 1
e) 1
BAHGE
<0. 007-0. 09 ug/g
net wt
a) Mat given
b) 1.6-1.7 pp»
c) 1.6-3.6 pp.
d) Not applicable
e) Hot applicable
Dry »t
a) Hat given
b) Hot applicable
c) 1.7-1.1 pp.
d) Hot applicable
e) Hot applicable
Dry wt
SEAN
Not given
a) <0.4 pp.
b) 1.6 pp«
c) 2.4 pp.
d) 1 . *i PP*
e) 3. 1 pp»
Dry lit
a) 4.8 tor- 2.7 pp«
b) 2.0 pp.
c) 2.9 pp.
d) 2.7 ppl
e) 6.0 ppi
Dry «t
GEBERAL IHFOEHATIOH
Category 1 (first priority element)
as proposed by International Workshop
on Monitoring Environmental Haterials
and Specimen Banking
Autopsies, Baltinore, HDr
Kinneapolis, tin. and Seattle, HI
IOPT1AHD; HIHHESOrA; VASHI8GTON;
AOTOPSIES; 1I7EB; HEASOHEHEHT
BE1HODS: ftLUBIHUH; AKTHOHT; AESEDIC;
BAEIUrt; CACniOM; CHBOBIOH; COBALT;
COPPEB; FWOEIHE: IEOS ; LEAD;
HAHGAHESE; BEBCBET; nOLTBDEHOB;
NICrEL; HOBIDIDB; SELBHIUfl; SIL7EB;
51BOHTIOH: THA1LIOB; TI»: VAHADIOB:
ZIBC; POPULATION EZPOSDBE
a) Noraal healthy ien
b) Chroaia. plating workers
c) Chroaate refining workers
d) Airplane painter
e) Stone kason
Autopsies
Japan
JAPAX; ADDLTS; 10TOPSIES; ADRENAL
GLABDS; AOBTA: BOHES; BEAET;
IHTESTIHES; KID NETS; LITEB; LD1IGS;
LIHPH HODBS; PABCBEAS; SPLEES;
STOKACB; TBTBOID GLANDS; TRACHEA;
ALDHINOn; BABI09; CADHIDH; CALCIUB;
CHBoainn; COBALT; COPPEB; IBOH; LSAD;
nAGNeslDII; HANGAHESE; BETA IS;
nOLtBOERUn; NICKEL; PROSPBOBDS;
POTASSIOBJ SILICOH; SILVER; SODIOB;
STEOHTinfl; TIN; TITANIOB; VAHADIOB;
ZIHC; BIOACCOBOLATIOII; BEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCOHIUH; ELEHEBTS
a) Norial healthy Men
b) Chro.in. plating worker
c) Chroiate refining workers
d) Airplane painter
e) Stone aasoc
Autopsies
Japan
JAPAH; ADDLTS; AOTOPSIES; ADRENAL
GLANDS; AOFTA; BOHES; REAET;
ISTESTISES; HIDSE1S; LI7BB ; LDKGS;
LTHPH NODES; PAHCEEAS; SPLEEN;
STOHACR; IHYEOID GLANDS; TRACBXt;
ALOHIHOB; BARIUM; CADHIDB; CALCIDB ;
CBROSIUB; COBALT: COPPEB; IRON; LEAD;
HAGNESIUH; BANGANESE; METALS;
BOLTBDENOH; NICKEL; PBOSPHOHOS:
POTASSIUB; SILICOH; SILVER; SODIOH;
STEOHTIOB; TIN; TITANIDI; VANADIOB;
ZIHC; BIOACCOaOLAUOS; HEALTfl
HAZARDS; OCCUPATIONAL BAZARDS;
TONGUE; ZIBCONIOB; ELEHESTS
REFERENCE
Harrison, S.H.
Zei.sler, R.
Vise, S.A.
1981
EPA 600/S1-81-025, 6
pp.
Teraoka, B.
1981
Archives of
36(«): 155-165
Teraoka, H.
1981
Archives of
36(4). -155-165
(HBIT PiGE)
-------
vanadium
70HO-62-2
1
At» 50.9ml, HP 1917 C. BP 3000 C, YP 1 •« Eg at 2290 C, 10 •• Bg at 2570 C
(CONTINUED)
6866
Pancreas
6667
Spleen
6668
Stomach
ORE ROUTE
ANALYTICAL
HETHOD
BS
ES
ES
SMEER
OF CASES
5
a) 9
b| 2
c) 3
d) 1
e) 1
10
BA»GB
Not given
a) Mot given
b) <0. 1-2.0 PP»
c) 0.81-3.5 PP«
d) Not applicable
e) Hot applicable
Dry ut
Not given
BEAU
<0.« ppm dry «t
a) <0.4 ppm
b) Not given
c) 2.2 pp»
d) 3.5 ftm
e) 1.3 ppm
Dry wt
0.49 +or- 0.24 ppa
dry wt
GEHEFA1 ISPOBHVriOH
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART:
INTESTINES; KIDNEYS; LITER; LUNGS;
1Y1PH NODES; PANCREAS; SPLEEN;
STOHACH; THYROID GLANDS; TRACHEA;
AIUHIN0H: BARIUH; CADHIUB; CALCIOH;
CBBOBIOH; COBALT; COPPEB; IRON; LE1D;
BAGNESIUH; UHGl«ESE; RETILS;
KOLTBDENOH; NICKEL; PROSPHOROS;
POTASSIOH; SILICON; SIL7BH; SODIUB;
STRONTIOn; TIN; TITANinH; TiNtDinn;
ZINC; BIOACCnnOLATIOH; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIBCONIUB; ELEflENTS
a) Noraal healthy nen
b) Chroffliua plating workers
c) Chrosate refining workers
d) Airplane painter
e) Stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRE'NAL
GLANDS; AORTA: BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
IYBPH NODES; PANCREAS; SPLEEN;
STOBACH; TBTBOID GLANDS; TRACHEA;
ILOBINUB; BARIUB; CADHIUB; CALCIUB;
CHROHIUB; COBW.T; COPPER; I8O8; LEAD;
BAGNBSIUB; BANGANESE; BETALS;
BOLYBDENUB; NICKEL; PHOSPHORUS;
POTASSIUfl; SILICON; SILVER; SODIUB ;
STRONTIUB; TIN; TITANIUB; VANADIOB;
ZINC; BIO ACCUMULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIOH; ELEBENTS
Nornal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTl; BONES; HEART;
INTESTINES: KIDNEYS; LIVEH ; LUNGS;
LYBPR NODES: PANCREAS; SPLEEN;
STOHACH; THYROID ELANDS; TRACHEA;
ALUHINUB; BARIUB; CADBIUB; CALCIUB;
CHROBIUB; COBALT: COPPER; IRON; LEAD;
BAGNESIUB; BANGANESE; BETALS;
BOLYBDENUB; NICKEL; PHOSPHCRDS;
fOTASSIUH; SILICON; SILVER; SODIUH;
STRONTIOB: TIN: TITANIOfl; VANADIUB;
ZINC; BIOACCUnULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUB; ELEBENTS
REPERENCE
Teraoka, R.
1981
Archives of
36(») 1 155-1 65
Teraoka, R.
1981
Archives of
Environaental Health
36 (»): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(») : 155-165
(NEXT PAGE)
IS3
•^1
OJ
-------
vanadiun
TCtO-62-2
V
At» 50.9111, HP 1917 C, BP 3000 C, IP 1 an Bg at 2290 C, 10 •• Bg at 2570 C
(CONTINUED)
TISSUE
6869
Thyroid
gland
6870
Tongue
6871
Trachea
EXPOSURE EOUTE
ANALYTICAL
BETBOD
ES
ES
ES
NUBEEE
or CASES
1
2
2
BINGE
Not given
Mot given
Hot given
BEAN
<0.67 +or- 0.19 ppm
dry wt
-------
Vitaiin A
11103-57-*
EXACT COBPOSITIOB U«KNC«N CR UNDETERMINED
TISSUE
6872
Blood,
serui
EXPOSURE ROUTE
ANALYTICAL
BETBOD
_
NUMBER
Of CASES
10
B4NGE
a) 2.87-11.00 IU/»1
b) 2.66-10.20 I0/«l
BEAN
a) 5.88 tor- 0.88
iu/»i
b) 5.39 *or- 0.83
ID/Hi
GEHEBAL INFORBATICN
a) Before heaodialysis
b) After 8 br heaodialysis
slight decrease after heiodialysis
did not justify supplementation
Patients with chronic ureiia
CAROTENOIDS: KIDNEY DISEASES: BLOOD
SZRUM; BEMODIALISIS; VITAMIN A;
ISRAEL
Gotloib, L.
sklan, D.
nines, K.
1978
Journal o£ the Aaericao
Heaical Association
239(8) :751
Zinc
7»»0-66-6
Zc
At« 65.38, 8P 119.5 C, BP 908 C, 7P 1 •« Hg at 187 C, 10 » Hq at 590 C
TISSUE
6873
Adrenal
gland
68711
Aorta
"IXPOSOSE BOUIE
ANALYTICAL
HETHOD
ES
ES
HOKBEE
OF CASES
7
7
RANGE
Not given
Not given
HEAB
69 tor- 20 pp» dry wt
83 «-or- 12 ppa dry wt
GENERAL INFORMATION
Nornal tissue
Autopsies
JAPAS; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LITER; LDN.GS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
AIOBIBUB; BARIOB: CADBIUB; CALCIUB;
CHROBIDB; COBALT; COPPER; IRON; LEAD;
BAGNESIOB; MANGANESE; BETALS;
BOIYBDENUB: NICKEL; PHOSPHORUS;
POTASSIU8; SILICON; SILVER; SODIOS;
STRONTIUH; TIN; TITANIUM; VANADIUM;
ZINC; BIOACCUBOLATION; HEALTH
HAZARDS; OCCUPATIOBAL HAZARDS;
TONGUE; ZIRCONIUH; ELEBENTS
Nornal tissue
Autopsies
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUNGS;
L1BPH SODES: PASCBEAS; SPLEEN;
STOHACH; THYROID GLANDS; TRACHEA;
ALUBINUH; BARIUM; CADBIUB; CALCIUB;
CBROMIUB; COBALT; COPPER; IRON; LEAD;
MAGNESIUM; BANGANESE; BETALS;
MOLYBDENUM; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON: SILVER; SODIUM:
STBOHTIUB; TIN; TITANIUM; VANADIUM;
ZINC; BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATION Al BAZiEDS;
TONGUE; ZIRCONIUM: ELEBENTS
REFERENCE
Teraoka, H.
1981
Archives of
36 (U): 155-165
Teraoka, H.
1981
Archives of
36(1) : 155-165
K>
(NEXT PAGE)
-------
Zinc
7MO-66-6
Zc
At« 65.38,
HP «19.S C, BP 908 C, vp 1 » Hq at 187 c, 10 » Hg at 590 C
(COHTIHOED)
TISSOE
6875
Blood,
cells
6876
Blood,
plasaa
6877
Blood,
plaSia
6878
Blood,
plasia
EIPOSOEE HOOTE
Ingestion
._
AHALITICAL
HETHOD
..
AAS
AAS
us
NUflBEE
OF C1SE5
3
6
a) 12
b| 19
2
E4HGE
a) 5.7- 10. 1 ug/ll
b) 6.4-8.7 ug/al
a) 93-97*
b| 105-103%
c) 92-79X
d) 92-9lt!t
. . _ -
a) 52-155 ug/dl
b) 53-113 ug/dl
a) Not applicable
b) Hot applicable
c) Dot applicable
1 IIEAH
a) Rot given
b) Hot given
a) Not given
b) Hot given
c) Hot given
d) Hot given
a) 82 »or- 1.3 ug/dl
b) 77.0 »or- 3.0
ug/dl
s.e.
a) 87 ug/100 ml
b) 96 ug/100 .1
c) 9« ug/100 «1
GEBEBAL INFOBHATIOH
a) Pretreatrent
b) After 2n therapy
Range of Beans
2.6-12 yr old children with
acrodernatitis enteropathica
Therapy decreased irritability.
Remission laintaioed by 1-2
iq/kg/day.
CHILDREK; DISEASES: HOTEITIOHAL
DEflCIEHCIES; BLOOD; HAI8;
IHTESTIBES; SKIH; UBIHE; HSTALS; ZIHC
a) Fasting
b) Ethanol (35 g)
c) Food
d) Food and ethanol
Percent at 9 An base value of 0.39
*or- 0.02 ug/«l, at 11 AH and 3 P«.
Significant decrease in c) and
significant difference between c) and
3)
Esti Bated froB graph.
Healthy 21-36 yr olds
BLOOD PL&StU; COHPA BAT IV?
ET&LD&TIONS; ALCOHOLS; METALS; KIHC;
FOODS
a) Fasting men (21 saaples)
b) Fasting woven (25 sa IB pies)
So significant difference between a)
and b)
Levels increased by 85 ug/dl at 2 hr
after 25 «g dose (as 110 »g ZnSOd) .
Increase significantly reduced by
coadninistration of nonhe«e Fe (25-75
•g ferrous salf ate) , bat not by he«e
iron (75 >g he«e chloride) . Ronhene
Fe (100 ag) did not have significant
effect when Zn (51 ag) given as 60 g
rav Atlantic oyster
Real thy adults
ADULTS; HDTBITIOHAL DEFICIEHCIES;
BLOOD PLASni; COflPARATIVE
EVALOATIOHS; IBOH; HETALS; ZINC;
DIETS
a) Beginning of study, 2 subjects
b) Subject 1, end of study
c) Subject 2, end of study
Study period, 20 days «ith 50*
caloric intake froa white bread
followed by 20 days in vhich high
fiber Boderate phytate, local bread
replaced white bread
35 and 2« yr old, vt 56.0 (• 60.3 kg.
Iran
IBM; ADOLTS; HOTEITIOHAL
DEFICIENCIES; BLOOD PLASBA; BLOOD
SEBDK; URINE; C A LCI OH; BIGBESCTB;
EBOSPHOBOS; ZIHC; DIETS; FIBEES;
FOODS; BBT1LS
EEFEBE»CE
Halravens, p. A.
Haibidge. K.fl.
Heldner, K.H.
Silveraan, A.
van Doorninck, N.J.
Hierau, 6.
Favara, B.
1978
93 (1):71-73
Bichards, B.
Flint, D.H.
"ahlquist, K.I.
1981
Hutrition Reports
International
23 (5): 939-943
Solovons, N.H.
Jacob, R.A.
1981
31t»75-«82
Beinhold, J.G.
Faradji, B.
Abadi, P.
Isiail-Beigi, F.
1976
Journal of Nutrition
106:193-503
(•BIT PAGE)
KJ
—J
-------
Zinc
711140-66-6
Zo
At» 65.38, HP 019.5 C, BP 90B C, VP 1 •• Hg at 187 C, 10 •> Hg at 590 C
(COIIZiaED)
6879
Blood,
plasma
6880
Blood,
plasma
6881
Blood,
plasna
EX £050 BE BOOTE
Ingestion
AHALYTICAL
METHOD
AAS
AtS
AUS
BIBBER
OF CASES
6
SO
110
BADGE
a) 80-108 ug/dl
b) 70-102 as
c) 63-104 U?
/41
/dl
d) £6-101 ug/dl
a) Hot given
b) Hot given
a) Hot give
b) Hot give
c) Hot give
d) Hot give
e) Hot give
f) Hot give
g) Hot give
a) Hot give
i) Hot give
3) Hot give
k) Hot give
11 Hot give
m) Hot give
n) Hot give
o) Hot give
p) Hot givei
i
q) Hot given
r) Hot givei
i
s) Hot given
BEAU
A) 97 *or- 11 ug/dl
b) 89 *or- 12 ug/dl
c) 91 «or- 15 ug/dl
d) 85 *or- 12 ug/dl
a.) 11. 18 tor- 2.6
umol/1
b) 6.88 +or- 2.83
umol/1
a) 71.7 +or- 0.96
ug/100 ml
b) 70.1 »or- 5.1
ug/100 ml
c) 75.1 *or- 2.0
ug/100 ml
d| 76.2 +or- 1.3
ug/100 ml
e) 77.9 *or- 1.8
ug/100 ml
f) 80.7 ug/100 ml
g) 66. » »or- 7.0
ug/100 ml
h) 75.6 *or- 1.7
ug/100 ml
l) 75.2 +or- 1.5
ug/100 ml
j) 77.9 «or- 1.8
ug/100 ml
X) 79.3 +01- 2.2
ug/100 ml
1) 72.0 +or- 2.5
ug/100 ml
m) 73.1 +or- 1.6
ug/100 ml
n) 77.1 +or- 2.0
ug/100 ml
o) 77.3 +or- 2.0
ug/100 ml
p) 76.8 »or- 2.9
ug/100 ml
q) 76.9 »or- 4.7
ug/100 ml
r) 71.1 +or- 6.7
ug/100 ml
s) 73.3 +or- 6.4
ug/100 ml
S.E.
GEHEBAL IHFORHATIOH
a) Initial Beasureaent
b) After 1 «k lo. Zn diet
c) After 2 wk lov Zn diet
d) After 3 «k low Zn diet
23-aH yr old Onlversity of Teras
students in good health vith adequate
Za
HDTBITIOHAL DE?ICIEHCIES; TEIAS;
* COLTS; SE<; BLOOD PLASDA; SALIVA;
ZIHC; BIOIHDICATOBS; DIETS
a) 19 healthy controls
b) 31 patients with acute lyocardial
infarction
Close correlation betveen fall in
plasia Zn and rise in CPK
(creatinine-paospbate-kinase) in
acute lyocardial infarction patients.
B100D PLASIJA: CABDIOVASCIILAB
DISEASES: HEART DISEASES; COPSEB;
BAGHESIOB; HAHGAHESE; ZIHC
a) All children
t) Jelght, 85-89*, 5 children
c) Height, 90-91X, 18 children
d) Height, 95-99%, »6 children
e) Height, 100-101*. 20 children
f) Height, > or « 105T, 2 coildren
q) Height, 85-89%, 1 children
h) Weight, 90-9»», 15 children
i) Height 95-99K, 31 children
3) Height 100-10»%, 21 children
k) Height > or = 105K, 19 children
1) Ar« circumference, 80-81*, 5
children
•) Ara circunference, 85-89*, 26
children
n) Arm circumference, 90-91*, 23
children
o) Arm circumference 95-99', 22
children
p) Arm circumference > or - 100*, 16
children
q) Taste acuity normal, 55 children
r) Hild hypogeusia, 17 children
s) (federate and severe hypogeusia, 1
children
Height, weight, and arm
circumference, as * of median levels,
significantly correlated with Zn
level. Moderate to severe hypogeusia
significantly associated with low Zn
levels
9-12 yr old school children,
Yugoslavia
YUGOSLAVIA; CHILDBEH; BUTEITIOHAL
DEflCIEHCIES; BLOOD PLASHA; HAIB;
HETALS; ZIHC
(MBIT PAGE)
DEFERENCE
Freeland-Graves, J.H.
Hendrickson, P.J.
Ebangit, B.L.
Snowden, J,T.
1981
American Journal of
clinical nutrition
31:312-321
Zumkley, H.
Bertram, H.P.
Vetter, H.
Tank, B.
Wirth, 1.
1980
Trace Substances in
Environmental Healta
VIV, D.D. Remphill, ed.
pp 211-216
Buzina, B.
Jus ic, M.
sapunar, j.
ailanovic, ».
1980
American Journal of
Clinical nutrition
33(11) :2262-2267
NJ
—1
-------
Zinc
7110-66-6
zc
»t» 65.38, IIP 119.5 C, BP 908 C, VP 1 » Bg at 187 C, 10 » Bg at 590 C
(CONTINUED)
TISSUE
6882
Blood,
plasna
6883
Blood,
serun
6881
Blood,
serui
6885
Blood,
whole
6886
Body
EXPOSURE ROUTE
Ingestion
. -. . .
ANALYTICAL
METHOD
IAS
AAS
_
IAS
I-Ray
Spectroaetry
Badioftetry
NUMBER
OF CASES
a) 24
b) 21
C) 8
88
a) 26
b) 21
c) 52
d) 11
e) 10
£) 21
g) 10
hi 10
i) 10
27
12
BINGE
a) Not given
b) Hot given
c) Hot given
a) 0.65-1.23 ug/ll
b) 0.15-1.3 ug/ul
c) 0.15-0.8 ug/«l
d) 0.25-1. 48 ug/ll
a) Hot give
b) Not give
c) lot give
d) Hot give
e) Not give
f) Not give
g) Not give
h) Not given
i) Not given
Mot given
19-99*
MEAN
a) 12.8 +oc- 0.8
umol/1
b) 12.1 +or- 0.4
umol/1
c) 12.6 +or- 0.4
HBO 1/1
a) 0.92 +or- 0. 12
ug/nl
b) 0.68 +oc- 0. 13
ug/ll
ug/ll
dj 0.56 +or- 0.23
ug/ml
e) 1. 13 +or- 0. 23
ug/al
a) 1.2 tor- 0.6 ppm
b) 1.0 or- 0.6 ppm
c) 0.9 or- 0.4 ppn
d) 1. 1 or- 0 . 5 ppa
e) 1.0 or- 0.4 ppm
f) 1.1 or- 0.3 ppn
g) 0.9 or- 0.4 ppm
h) 0.9 or- 0. 1 ppm
i) 1.1 or- 0.2 ppa
6.1 ppm
Hot given
GENEBAL INFORMATICS
a) So Li therapy
b) Li therapy for 6 BO
c) Li therapy for T-2 yr
No significant differences
Hanic-depressive pa tients
DEBFRBK; BEHAVIOR DISORDERS; CENTRAL
NEEVOOS SYSTBH DISEASES; BLOOD
PLAS1A; DPOG THEEAPY; METALS; ZIHC
a) 28 controls
fc) 20-22 wk gestation, 60 subjects
c) 36-37 wk gestation, SO subjects
d) Postpartum, 29 subjects
Bangs estiiated from graph
Effects of snoking. alcohol, parity.
oral contracept ives considered
Healthy 19-24 yr old Caucasians
taking Fe and folic acid, no other B
vitamins. Controls, 18-23 yr old.
nonpregnant students, no vitamin
Ireland
IEELAND; ADULTS; BLOOD SBROH; HAIR;
ORAL CONTRACEPTIVES; ZIHC; ALCOHOLIC
BEVEB&GES; PHEGHAHCY.; SHOKING; METALS
a) Lung and respiratory tract
b) Gastrointestinal tract
c) Breast
d) Cervix
e) Lymphatic leukeBia
f) Malignant nelanoBas
g) Hodgkin*s lyaphoaa
h) Healthy volunteers
i) Geriatric patients
a) -g) type of cancer
so significant difference between
controls and cancer patients
Cancer patients (15-81 yr elds).
geiiatric patients (65-81 yr olds).
healthy volunteers (20-11 yr olds).
OK
UNITED KINGDOH; CAB CIKOflAS ; LEOKEniA;
niLANOMiS; NEOPLASMS; SARCOMAS; BLOOD
SZKU9; CALCIBB; COPPZB: HA6HESIOB;
"ABGSNESF; HETALS; ZINC;
BIOI8DICAT08S
Precision 7t. Accuracy within 10% by
ccnparison to atoaic absorption
spectronetry.
ELOOD; BEASOKEHENT METHODS; COPPER;
IEO»: BETALS; BOBIDIQH; SEL5BIOB;
ZINC
t of dose absorbed 24 hr after 1-2
uci Zn-65
Estiaated fro. graph
significant correlation vith urinary
excretion (p <0.001)
Patients with hypogeusia and hyposmia
DISEASES; BOOT; 08IHE; aEASDPEMCHT
4 HET80DS; ZISC; BADIOHUCLIDES; HBTfcLS
1-
FEFEBENCE
Schou, M.
Bolt, E.
1981
Acta Pharnacologica et
Toxicologica 19:298-300
vir, s.c.
Love, A.H. G.
Thompson, U.
1981
Clinical Nutrition
31:2800-2807
Capel, I.D.
Pinnock, M.H.
Williams, D.C.
Hanhan, I.H.F.
1982
Oncology 39:38-11
Bearse, B.C.
Close, D. A.
Balanify, J.J.
oabarger, C.J.
1971
Analytical chemistry
16(1) :499-503
Henkin, R.I.
Aaiodt, 8.1.
1975
Lancet
1 (7921) : 1379-1380
ro
^j
oo
(BEIT PAGE)
-------
Zinc
7400-66-6
Zn
»t» 65.38, at 419.5 C, BP 908 C, 7P 1 »» Eg at 487 C, 10 •• Hg at 590 C
(CONTINUED)
TISSOE
Body
6888
Eo3y
6689
Bone
6890
Bone
6891
Hair
EXPOSOBE ROUTE
Ingest ion
ANALYTICAL
HETHOD
Radiometry
ES
NA
NA
HOBEEE
OP CASES
75
5
a) 7
b) 5
58
BAHSE
40-86% of dose
Not given
a) 71-137 ppm
b) 92-102 ppm
143-191 ug/g
HEAN
65 +or- 11X of dose
200 *or- 56 ppm dry
vt
a) 104 pp«
b) 95 pp«
Medians
172 ug/g
G5BEPAL INFORMATION
(Zn-65) after 14 hr fast
Healthy 18-84 yr olds
BODY; METALS; ZINC
Intestinal absorption of 10 uci dose
Zn-65 after 14 hr fast
Healthy 18-84 yr olds
BODY; METALS; ZINC
Normal tissue
Autopsies
Japan
JAPAN; AD01TS; AOTOP5IES; ADRENAL
GLANDS; AORTA; BONES; BEABT;
INTESTINES; KIDHEYS; LIVEE; LU»GS;
IYBBH NODES; PAKCEEAS; SPLEEN; -
STOHACH; THYEOID GLASOS; THACHEA;
AinBINUH; BARIDB; CAOBIOB; CALCIUB;
CBECBinn; COBALT: COPPEP; IROS; LEAD;
BAGN5SIOM; HANGIHESE; HETALS;
BOLYBDENOH; NICKEL; PHOSPHORUS;
POTASSIOB; SILICOS; SILTSE; SODIOB ;
SIEONTIOB; UN; TITANIOB; VA1ADIOB;
ZINC; BIOACCOBOLAHON: HEALTH
HAZARDS; OCCOPATIONAl HAZARDS;
TON90E; ZIRCONIOH; ELEMENTS
a) Exposed group
b) Controls
Autopsies, femur
45-75 yr old factory workers, Sweden.
AKTIflOSY; AESENIC; CADBIUB; COPPER;
LEAD; BERCORY: SELE8IOB; SIL1TEE; TIN;
ZINC; BIOACCtJfltJLATION: INDDSTRIAL
JTJIOSPHEBES; ISDBSTBUL PL JUTS;
POPOLATIO» EJPOSOEE: SHELTERS; BOHES;
FEHUR; COBPARATIVE ETA LtJATIOSS ;
SWEDEN; ADTOPSIBS; OCCUPATIONAL
HAZARDS; BETALS
Range of means, 5 localities
Residents of Iceland
ADULTS; HAIR; ARSENIC; CADHIUH;
HEECURY; METALS; SELES IOB; ZIHC
REFERENCE
Ramble, B.F.
Johnston, G.S.
Markley, E.J.
Henkin, R.I.
1981
American Journal of
Clinical Nutrition
311:2648-2652
Aamodt, R.L.
Rumble, B.r.
Johnston, G.S.
Harkley, E.J.
Henkin, E.I.
1981
clinical Sutrition
34: 2648-2652
T era oka, H.
1981
Archives of
Environmental Health
36(4):155-165
Lindh, U.
Brune, D.
Nordberg, 3.
Hester, P.-o.
1980
Environment 16:109-116
Johannesson, T.
Lunde, G.
Steinnes, P.
1981
Acta Pharmacalogica et
Tolicologica 48:185-189
K3
-~J
VO
(NEXT PAGE)
-------
Zinc
THO-66-6
2n
At» 65.38,
BP 119.5 C, BP 908 C, VP 1 » Hq at U87 C, 10 » Hg at 590 C
(COHTIHOBD)
TISSUE
6892
Hair
6893
Hair
689H
Hair
EXPOSURE BOD1B
ANALYTICAL
tlETHOD
AAS
»A
H OH BEE
OF CASES
3
88
56
BAN5E
a) 66-89 ug/g
b) 75-120 ug/g
a) 127-225 ug/g
b) 110-238 ug/g
c) 88-222 ug/g
d) 98-208 ug/g
71. 3110 (E-6) -1521110(2-6)
g/cu CH
BEAN
a) Hot given
b) Hot given
a) 178.2 »or- 25.1
"9/9
b) 183 tor- 26 ug/g
c) 170 +or- 26 ug/g
319.7I10(E-6) g/cu on
GENERAL I»FORBATIO»
a) Pretreatient
b) After Zn therapy
Range of Beans
2.6-12 yr old children vith
acroderaatitis eoteropathica
nervousness, and restlessness.
«g/kg/aay.
CBILDBEN; DISEASES; HOTRITIOMJL
DETICIEKCIES: BLOOD: HAIR;
IHTESTIKES; SKI N ; 08ISE; BETA1S; ZISC
a) 28 controls
b) 20-22 vk gestation, 60 subjects
c) 36-37 ilk gestation, 50 subjects
d) Postpartu», 29 subjects
Effect of snoking, alcohol, parity,
oral contraceptives considered
Healthy 19-20 yr old Caucasians
taking Fe and folic acid, no other B
nonpregnant students, no vitaain
supplements no oral contraceptives.
Ireland
IBFLAND; ADDLTS; BLOOD SEROH; HAIB;
OBAl COHTBACBPTI»ES; ZIBC; ALCOHOLIC
BEVERAGES; PBEGHA1ICT; SBOICIHG; BEIALS
3 cm segments of single hairs
So»e saiples below detection liiits
iBiDinn; HAIE; TOBEHSIC BEDICIHE;
BEASDEEBEHT BETHODS ; ANTIHONT;
ARSENIC; BBOBIHE; COPPED; GOLD;
LANTHAN'JH; BUGtlESE; HEPCURY;
BETALS; SELEHIOB; SILVER; SODIHB;
SIROBTIDB; ZIHC; INDUSTRIAL
ATBOSPHERES
REFEBEKCE
Walravens, P. A.
Haabidge, K.H.
Neldner, K.H.
Silveraan, A.
van Doorninck, H.J.
Hierau, G.
Favara, B.
Journal of Pediatrics
vir, S.C.
Love, A.H.G.
Thompson, 9.
1981
Clinical Nutrition
3«:280 0-2807
Dybczynski, B,
Boboli, 1C.
1976
Journal of
Radioanalytical
Chemistry 31:267-289
(BEIT CAGE)
NJ
C»
o
-------
zinc
70UO-66-6
Zn
AtB 65.38. IIP 419.5 C, BP 908 C. If 1 » Hg at 187 c, 10 mm Hg at 590 C
(CONTINUED)
TISS0E
6895
Hair
6896
Hair
6897
Hair
EXPOS0RE ROt/TE
i NAUTICAL
BETHOD
IAS
NA
NA
H0.1BIB
OP CASES
.
110
65
BJNGE
a) Mot given
b) Hot given
c) Hot given
d) Not given
e) Hot given
£) Hot given
g) Hot given
h) Not given
i) Hot given
j) Hot given
k) Hot given
1] Not given
•) Not given
n) Not given
o) Not given
p) Hot given
q) Hot given
c) Not given
s) Not given
.
150—185 ug/g
a) 51-348 ppm
b) 77-177 pp«
c) 91-211 ppm
d) 71-171 pp*
BEAU
a) 90.3 tor- 2.6 ppm
b| 82.1 tor- 13.3 ppm
c) 90.1 tor- 4.5 ppm
d) 92.2 tor- 4.8 ppn
e| 95.9 tor- 6.2 ppm
f) 89.4 ppm
gi 73.7 +or- 6.0 ppa
h) 89.6 tor- 9.2 ppm
i) 88.6 tor- 3.5 ppm
j) 94.5 tor- 7.0 ppm
k) 94.8 tor- 6.5 ppm
1) 85.7 tor- 6.2 ppm
m) 88.4 tor- 5.3 ppm
u) 90.8 tor- 5.6 ppm
o) 93.6 tor- 4.0 ppm
g) 116.3 tor- 38.9
ppm
r) 91.6 *or- 45.4 ppm
s) 88.2 tor- 27.8 ppm
S.E.
.
given
a) 138 tor- 45 ppm
b) 137 tor- 25 ppm
c) 166 tor- 43.6 ppm
d) 126 tor- 26 ppm
GENERAL INFOB HATI C»
a) All children
b) Height, 85-89*, 5 children
c) Height, 90-94H, 18 children
d) Height, 95-99X, 46 children
e) Height, 100-104*, 20 children
g) Height, 85-891, 4 children
h) Height, 90-94*, 15 children
i) Weight 95-99*. 31 children
j) Height 100-104X, 21 children
k) Height > or - 105*. 19 children
1) Arm circumference, 80-84*, 5
children
m) Arm circumference, 85-89*. 26
children
children
children
p) Ari circumference > or - 100%, 16
children
g) Taste acuity normal, 55 children
r) Kild hypoqeusia, 17 children
s) Moderate and severe hypogeusia, 4
children
Height, veight, and arm
circumference, as % of median levels.
significantly correlated vith Zn
level, loderate to severe hypoqeusia
significantly associated vith low Zn
levels
9-12 yr old school children.
Yugoslavia
YUGOSLAVIA; CHILDSEH; HOTEITIOB AL
DEFICIENCIES; BLOOD PLASMA; HAIE;
BETALS; ZIBC
Asvan, El Kharga, Assuit, Cairo, and
Alexandria, Egypt
EGYPT; HAIP; HAIIS; ANTIBOSY;
CADBIOH; CESIOfl; CHKOBIUI; COBALT;
IEOH; BAHGAHESE; BETALS; BOLYBDEDtJB ;
SCAHDIOB; SELEHUJB: SILVER; TOSSSTEB;
ZIHC; DEIBKING HATES; POPHIATIOH
EIPOSBEE; SOILS; BSBAS ABEAS
a) 12 CD length, 106 samples
b) Root section, 18 samples
c) Distal section, 18 samples
d) Students in a) , 32 samples
Betropolitan Bombay, India
ISDIA; ADOLESCENTS; ADULTS: HAIR;
ABTIBOSY; AESEBIC; BROBI8E; CADBIOB:
CHLORINE; CHBOBItm: COBALT: COPPER;
G01D: IODISE; IRON; LASTHANOB;
BAKGSNESE; POTASSIOH; SCA»DI[IH;
SELEHIDH; SILVER; SOOIOH; ZIBC; AIB
EOLLnTION; BIOACCDHOLATIOB; FOSSIL
FOEIED POHER PLANTS; ISDOSTRIAL
AREAS; IKDOSTRIAI AMOSPHEB2S ;
IBDnSTRIAL EBISSIOKS; IBDOSTBIAL
POLLUTION; POPDLATION EIPOSOBE; ORBAN
ABEAS; INDUSTRIAL CHEBICALS
REFERENCE 1
Buzina, R.
Jusic, H.
Sapunar, J.
Bilanovic, H.
1980
Clinical Nutrition
33(11) : 2262-2267
lyengar, G.7.
Feinendegen, L.E.
Hashish. S.
Bahfouz. H.
1982
Science of the Total
Environment 22:149-168
Bhat, K.R.
Arunachalam, J.
Yegnasubramanian , S.
Gangadharan, S.
1982
Science of the Total
Environment 22:169-178
(NEXT PAGE)
00
-------
Zinc
•?
Dry wt
71 *or- 17 ppa dry wt
-
GEHEHiL IirOB8»IOI
a) Subject 1* unwashed hair
k) Subject 1, after 12 successive
acetone washes
c) Subject 2, unwashed hair
A) Subject 2, after 12 successive
e) Subject 3, unwashed hair
f) Subject 3, after 12 successive
washes in sodiun lauryl sulfate
a), c) , e) . 6-10 determinations, each
subject. Data also for other
procedures and washing agents.
«JIS; COHPiBATIVE EVILDJTIOHS;
CtDBIDB; COPPED; IRON; fUNGlSESE;
ZIHC
a) Normal healthy len
b) chroiiuB plating workers
c) chronate refining workers
d) Airplane painter
e) Stone lason
autopsies
Japan
JUPAN; ADULTS; AUTOPSIES; ADRENAL
&LAHDS; AORTA; B08ES; HEART;
INTESTINES; KIDNETS; LITER; LUNGS;
LYBPR NODES; PANCREAS; SPLEEN;
STOSACH; THtROID GLAHDS; TRACHEA;
ALCBIHOB; BARina; CADBinn; CALCItJB ;
CHROBIOB; COBALT; COPPE8; IRON; LEAD;
nAGHESIUH; SANGAHESE; RETALS;
BOLTBDESOR; HICK1L; PHOSPHOBBS;
SOTaSSIUS; SILICON; SILVER; SOBIUB;
STBOMTIDH; IIS; TITA8IOH ; VAHADIOn;
ZINC; BIOACCUBOLATION; HEAITH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUH; ELEBEHTS
Noraal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADREHAL
CUNDS; AORTA; BONES; HEAPT;
INTESTINES; KIDNEYS: LITER; LDNGS;
LIBPH NODES; PAHCBEAS; SPLEEN;
STOBACH; THTROID GLANDS; TRACHEA;
ALOBISOB; 31EIOH; CAD8IDB; CALCIOT ;
CBSOSIUB; COBALT; COPPER; IRON; LEAD;
BAGNESIUB; BAHGAHESE; HETALS;
BOLIBDEHUB; NICltELJ PHOSPHOBUS;
POTASSIUH; SILICOH; SILVER; SODIDB;
STBONTIOS; TIN; TIT AS I OB; VADADItia;
ZINC; BIOACCUHOLATION; HEALTH
HAZARDS; OCOJPATIOHM. HAZARDS;
TONGUE; ZIRCOHIDB; ELEHENTS
(SEIT PAGE)
Saliela, S.
Tuori, E.
tcilpio, J.O.
1981
Analytica Chisica Acta
125:131-137
Teraoka. H.
1981
Archives of
36(«): 155-165
NJ
C»
Teraoka, H>
1981
Archives of
Bnvironnental Health
36(4): 155-165
-------
Zinc
7«IO-66-6
Zn
At» 65.38. HP 419.5 C. BP 908 C, VP 1 » Hg at 487 C, 10 •• Hg at 590 C
(CONTINUED)
6901
Intestine
6902
Kidney
6903
Kidney
AMIrTICAI
HETHOD
ES
tts
ii t>9 BBS
or OSES
3
4) 8
b) 2
0) 3
«) '
123
HUGE
a) Hot applicable
b) Not applicable
c) lot applicable
.
a) Not given
b) 150-440 ft*
c) 180-330 pp«
e) Not applicable
Dry wt
a) Hot given
b) Not given
c) Hot given
d) Not given
e) Not given
gj Not given
h) Not given
i) Not given
BEAN
a) 77 ug/g
b) 321 ug/g
c) 97 ag/g
Dry weight
a) 150 *or- 72 PPD
b) 295 pp>
c) 250 pp«
e) 280 ppn
Dry wt
a) 6.5 or- 2.7 u«/g
b) 5.8 or- 2.9 uH/g
c) 5.3 or- 2.6 uM/g
d) 7.7 or- 2.7 uH/g
e) 7.6 or- 2.6 un/j
g) 8.0 or- 2.5 ua/g
h) 5. 1 or- 1.7 uH/g
i) 6.0 +or- 2.5 uH/g
GENERAL IHFORHATIOH
a) pretreataent
b) After 2 ao Zn therapy
c) 2 controls
Peroral jejuna! biopsies
12 yr old girl. 6-7 yr old controls.
Therapy decreased irritability.
nervousness, and restlessness.
ig/kg/day.
CHILDREN; DISEASES; HOTEITIONil
DEFICIENCIES; BLOOD; HUE;
INTESTINES; SKIN; 0RIHE; BETHLS; ZINC
a) Noraal healthy sen
b) Chromiun plating workers
c) Chronate refining vorkers
e) stone aason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADSEHAL
GIANDS; AODTA; BONES; HEABT;
INTESTINES; KIDNEYS; LIVER; LONGS;
LyBPH NODES; PANCREAS; SPLEEN;
STOHACH; TRtROID GLBNDS; TRACHEA;
ALOHINOB; BARI08; CADBIOB; CALCIOH ;
CHROHIOn: COBALT; COPPER; IRON; LEAD;
BAGNESIDB; BANSANESE; HETALS;
HOLIBDEHnH; NICKEL; PHOSPHORUS;
POTASSIOB; SILICON; SILVER ; .SODIOB :
siRONTinn; TIN; TITANIOB; VANADIBB;
ZINC; BIOACCOBOLATIOS; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGDE; ZIRCONIUH; ELEBENTS
a) All cases
b) Hypertension. 35 cases
c) Atherosclerosis. 45 cases
d) Cancer, 32 cases
e) Cancer and netastases, 16 cases
M Renal disease, U cases
1) Other, 28 cases
Autopsies
Postiive significant correlation
between Zn and cd in all cases.
Snoking and nonsnoking patients
CADBIUB; HETALS; SELENIDB; ZINC;
CADAVERS; CARCINOBAS; HIPEBTENSION;
KIDNET DISEASES; LEDKEHIA; KIDNETS ;
SBOFING
1 . _ . . . _
EEPEREKCE
Halravens, P.A.
Hanbidge, K.B.
Neldner, K.H.
silvernan, A.
van Doorninck. H.J.
Bierau, G.
Favara, B.
1978
Journal of Pediatrics
T era oka, H.
1981
Archives of
36(4): 155-165
Shaaberger. R.J.
Bratush, C.H.
1980
Proceedings, University
Substances in
Environmental Health
14:203-210
(NEXT PAGE)
co
UJ
-------
Zinc
7440-66-6
Zn
At» 65.38,
6904
Liver
HP 119.5 c. BP 908 C. If 1 •> Eg at 487 C. 10 mm Hg at 590 C
(CONTINUED)
6905
Liver
6906
Long
EXPOSURE ROOTS
ANALYTICAL
BETHOD
IS
_
AST
1ST
II
ES
I0HBEB
or OSES
a) 9
b) 2
c) 3
4) 1
el 1
30
-
a) 12
b) 2
c) 3
d» \
e) 1
BAHGE
a) lot given
b) 86-220 PPB
c) (5-400 ppi
d) Mot applicable
e) lot applicable
Dry lit
31-30 ag/g
let tit
a) lot given
b) 86-220 fpm
c) 65-400 ppi
4> lot applicable
e) Hot applicable
Dry wt
BEAU
a) 210 +or- 89 ppi
ta) 153 ppi
c) 198 ppi
d) 87 ppi
e) 270 ppi
Dry ¥t
Hot given
_
a) 77 +or- 22 ppi
b) 153 ppi
c) 198 ppi
4) ft! pj>»
e) 270 ppi
Dry wt
GENERAL INFOBHATION
a) Normal healthy iien
b) Chroaiui plating workers
c) Chronate refining uorkers
d) airplane painter
e) Stonp Bason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADSEHAL
GLANDS; AOBTA; BONES; HEART;
IBTESTI»ES; KIDBEIS; LIVES; LONGS;
LTBPH NODES; PASCEEAS; SPLEEN;
STonscH: THYROID GLANDS; TPACHE*;
ALnniNnn; BASina; cioainB; CALCIOB:
CHEOBItIB; COBALT; COPPEB; IBO»; LEAD;
BAGKESIOB; BANGANESE; BETAIS;
BOLIBDEBOB; SICItPL; PHOSPHOBOS;
POTASSIOB; SILICON; SILVEE; SODID1;
STBOHTI09; TIN; IITANIOH; VABADIOB;
ZINC; BIOACCO«HI,iTIO«; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIBCONIOB; ELEBEHTS
Category 1 (first priority eleaent)
a£ proposed by International Hockshop
on Bonitoring Environaental flaterials
aod Specinen Banking
Aatopsies, Baltinore, BD,
Binneapolis, BN, and Seattle* HA
BABTLAND; HISNESOT*; RASHINGTON;
ADTOPSIES; LIVEB; BEASDREBENT
BETHODS; AUJBINUB; ABTIBONT; AESENIC;
EARIOS; CADBIOB; CHEOBIOB; COBALT;
COPPEB: FLOOBINE; IRON; LEAD;
B&HGAHESE; BEBCaBI; BOITBDEBOB;
NICKEL; BOBIDIUH; SELEBIOB; SILTEE;
ST10NTIDB; TBALLIDB; TIN; VANADIUM;
ZINC; POPULATION BIPOSUBE
a) Norial healthy aen
b) chroaiua plating workers
c) chroBate refining workers
A) Airplane painter
e) Stone nason
Autopsies
Japan
JAPAN: ADULTS: ADTOFSIES; ADBENAL
GLANDS; AOBTA; BOIES; BEABT;
IFTESTINES; KIDNEIS; LIVES; LONGS;
1TBPH IODES; PiUCBEIS; SPLEEN;
STOBACB; TBTBOID GLANDS; TRACHEA;
ALUBIIUB; BABIOB; CIDBIUB; C&LCIUH;
CEBOBIUB; COBALT; COPPEB; IRON; LEAD;
BAGNESIDfl; BAHGABESE; METALS;
nOLIBDENOB; NICKEL; PHOSPBOBUS;
POTASSIUfl; SI1ICOB; SILVER; SODIUB:
STEONTIUB; TIN; TIT1NIUB; TANADIOB;
ZINC; BIOACCOBOLATI08; HEALTH
HAZARDS; OCCUPATIONAL HAZABDS;
TONGUE; ZIBCOIIUB; ELEBENTS
(HEIT PAGE)
Teraoka, B.
1981
Archives of
E&vironBental Health
36(4): 155-165
Harrison, S.H.
Zeisler. B.
Dise, S.A.
1981
EPA 600/S1-81-025. 6
pp.
00
Teraoka, H.
1981
Archives of
Environlental Health
36(4): 155-165
-------
Zinc
7440-66-6
Zn
At» 65.38, SP 119.5 C, BP 908 C, It
1 mm Hg at 187 C, 10 mm Hg at 590 C
TISSUE
6907
Lymph
6908
Nail
6909
Pancreas
6910
Saliva
EXPOSURE ROUTE
Ingestion
ANALYTICAL
BBTHOD
ES
Hi
ES
US
BOBBER
or CASES
a) 3
b) 1
c| 3
a) i
el 1
66
5
7
BUGS
a) Hot given
b) not applicable
c) 7«-380 pp«
d) lot applicable
e) Hot applicable
Dry wt
130-250 ug/g
Hot given
a) 172-413 ng/ml
b) 157-438 ng/ml
c) 171-549 ng/>l
d) 178-537 ng/»l
HE IN
a) 110 tor- 34 pp*
b) 110 ppm
c) 228 ppm
d) 150 PP»
e) 600 ppm
Dry wt
Hot given
120 tor- 30 pp» dry
wt
a) 266 +or- 89 lig/mi
b) 280 +or- 111 ng/ml
c) 302 »or- 136 nq/»l
d) 312 tor- 128 ag/al
GENERAL IHPOEBATIOII
a) Honal health; >en
b) Chromiui plating worker
c) chroaate refining workers
d) Airplane painter
e) Stone Bason
Autopsies
Japan
JJP»S; ABOLTS; IOTOPSIES; ADRENAL
eltKDS; AOETt; B08ES; HEART;
IBTESTIHES: KID NETS; IIVEF; LD»SS;
L1BPB NODES; Pi NC BE AS; S PLIES;
STOHACH: THYROID GL4HDS; TBACHEl;
ALUBIITOB; BABIUB; CADBIUH: CALCIOB;
CBSOBIDH; COBALT: COPPES; IBOH; 1EAD;
HAGHESIOH; BANGiHESE; BETALS;
BOLYBDEtlOB; HICKEL: PHOSPHOROS;
ponssinn; siLicoH; SIIVEE; SODIDS;
STBOBTI08: TM; IIUKIOII; V»»»DIO!!;
ZIKC; BIOACCBBHLATI01I; HEA1TB
HAZARDS; OCCUPATIONAL HAZARDS;
TCSGOE; ZIECOSIOB; ELEHEHTS
Range of neans, estimated froa graph
Asvanf El Kharga* hssait, Cairo, and
Alexandria, Egypt
EGIPT; HAIR; SAILS: AHTTHOHY;
CADBIDB; CESIOn; CHSOBIOB; COBALT;
IRON; HAHGAHESE; BETALS: BOLYBDEHO B;
SCAHDItlB; SELE»IOH: SILVER; TDHGSTEH;
ZIHC; DRISKIHG SATEB; POPOLATIOS
EXPOSURE; SOILS; OFBAH AREAS
Hormal tissue
Autopsies
Japan
JAPAN; AD1TLTS; AUTOPSIES; ADRENAL
GLANDS; AORTA; BOHES; HEART;
INTESTINES; KIDNEYS; LIVER; LONGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOHACH; THtBOID GLANDS; TRACHEA;
A10SINBH; BABItm: CAOBIDH: CALCIDB;
CEROBinB; COBALT: COPPEB: IBON! LEAD:
BAGNESIDn; BANGANESE: BETA LS ;
BOLYBDEHOB: NICKEL; PHOSPHORUS!
POTASSIUB; SILICON: SILVER; SODIOB;
STRONTIOM; TIN; TITANIOH; VANADIQB;
ZIHC; BIOACCUBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCOHIUH; ELEBEHTS
a) Baseline levels
b) After 1 vk on low Zn diet
c) After 2 vk on low Zn diet
d) After 3 wk on low Zn diet
Range of Beans for individual
23-44 yr old university of Texas
students in good health with adequate
Zu
NUTRITIONAL DEPICISHCI ES; TEXAS;
ADULTS; SEX; BLOOD PLASHA; SALIVA;
ZINC; BI01NDICATOES; DIETS
REFERENCE
Teraoka, H.
1981
Archives of
Environmental Health
36 (4): 155-165
Kasperek, K.
I yen gar, G.v.
Feineadegen, L«E.
Hashish, S.
Hahfouz, B.
1982
Science of the Total
Environment 22:149-168
Teraoka, H.
1981
Archives of
Environmental Health
36(4): 155-165
Preeland-Graves, J. H.
Hendrickson, P.J.
E ban git, H. L.
Snowden, J.Y.
1981
Clinical Nutrition
34:312-321
(NEXT PAGE)
N3
00
Ln
-------
zinc
7440-66-6
Zn
AtB 65.38, IIP 119.5 C, BP 908 C,
Hg at 187 C, 10
Hg at 590 C
(CONTINUED)
TISSUE
6911
Salivary
sediment
6912
Skin
6913
Spleen
69 14
Stomach
EXPOSOP.E ROOTE
Ingestion
ANALYTICAL
IIETHOD
AAS
IS
ES
NOKBEB
OF CISES
5
5
a) 9
b) 2
d) 1
e| 1
10
HINGE
a) 101-162 ug/g
b) 79-118 ug/g
a) Not given
b) Hot given
c) Dot given
d) Not given
a) Hot given
b) 63-040 pp»
d) Hot applicable
e) Hot applicable
Dry wt
Not given
(KBIT
BEAN
a) Not given
b) Hot given
a) 6.7 ug/g
b) 10. 4 ug/g
c) 26.3 ug/g
d) 22.43 ug/g
Dry weight
a) 84 *or- 30 pp»
b| 254 pp.
d) 120 ppm
e) 330 ppa
Dry vt '
71 +OE- 17 ppa dry vt
P4GE)
GENERAL INFORBATION
a) Baseline levels Zn
k) After low Zn diet for 22 Says
Estimated from graph
23-44 yr old Onivecsity of Teras
Zn
BDTEITIONSI, DEFICIENCIES; TEXUS;
4DDLTS; SET; BLOOD PLASH*; SALIVA;
2ISC; BIOIHDIC1TOES; DIETS
a) Pretreatient , 1 subject
b) After 2 »o Zn therapy, subject a)
c) After 13 to Zn therapy, subject a)
d) 4 controls
Subject a) 31 no old boy
Therapy decreased irritability,
nervousness, and restlessness.
•gAg/day.
CHILDBED; DISEASES; 10TEITIOSAL
DEFICIENCIES; BLOOD; HUB;
INTESTINES; SKIN; OSINE; BETALS; ZINC
a) Normal healthy ten
b) chroniui plating vorXers
d} Airplane painter
e) stone lason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEART;
IKTESTINES; KDHEYS; LI7ER-, LONGS;
ITSPH NODES; PANCBEAS; SPLFBN;
STOPIACH; THIBOID GLANDS; IBJCHE*;
ALOnlNnd; BABI09; CADBIOS; CALCIBH;
CHEOBIOB; COBALT; COPPIB; I8ON! LEAD;
BAGSESID1; flASGANESE; BETALS;
BOLYBDENOH; NICKEL; PHOSPHOEOS;
POT1SSIDH; SILICOB; SILVER; SODItJB;
STBONTIOB: TIN; TITANIOB; VANADIOB;
ZIHC; BIOACCOMDLiTIOH; HEALTH
HAZISDS; OCCOPIIIONAL HAIKSDS;
TONGOE: ZIP.CONIHII; ELEBEHTS
Nornal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLIHDS; AOETAJ BOHES; HEABT;
INTESTINES; KIDHEYS; LIVER; LONGS;
LYBPH NODES; PAHCEEAS; SPLEEN;
SIOBACH; THYBOID GLANDS; TRACHEA;
ALOBINOH; DAEIOH; CADHIDB; CALCIOB ;
CBHOBinB; COBALT: COPPER; IRON: LEAD;
H1GNESI&H; BANGANESE; BETALS;
HOLYBDENOB; NICKEL; PHOSPHORUS;
POTASSIOH; SILICOH; SILVER; SODIDS;
STRONTIDB; TIN; IITINIDB; VADADIOB;
IIUC; BIOICCIOTLITIOH; HEMTB
HAZJIDS; OCCOPATIORAL HAZARDS;
TONGUE; ZIBCOHIOH; ELE9ENTS
REFERENCE
Freeland-Graves, J.H.
Hendrickson, P.J.
Ebangit, B.L.
Snowden, J. Y.
1981
Clinical Nutrition
34:312-321
valravens, p. A.
Haubidge, K.H.
neldner, K.H.
silversan, A.
van Doorninck, tf.J.
Nierau, e.
Favara, B.
1978
93(1):71-73
Teraoka, H.
1981
Environmental Health
36(4) : 155-165
Teraoka, S.
1981
Archives of
Environmental Health
36(4): 155-165
ho
00
-------
Zinc
71IHO-66-6
Zn
At« 65.38. BP 419.5 C, BP 908 C, If 1 u Bg at 187 C, 10 II Bg at 590 C
(CONTINUED)
TISSUE
6915
Thyroid
gland
6916
Tongue
6917
Trachea
6918
Orine
EXPOS0RE BOOTS
I&gestion
ANALYTICAL
BETBOD
ES
ES
SS
Radiometr;
KtMBBB
OF CASES
Not given
Not given
.01-.15 uCi
80 +or- 13 ppa dry wt
65 *or- 7.8 ppm dry
32 *or- 11. pp« dry
Not given
(NEXT PAGE)
GENERAL INFORMATION
Normal tissue
Autopsies
Japan
JAPAN; AD01TS; AUTOPSIES; ADRENAL
GLAHDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVES; LUNGS;
LYBPB NODES; PANCREAS; SPLEEN;
STOMACH; THYROID GLANDS; TRACHEA;
ALCBINUB; BARIUB; CADBIUH; CALCIOB;
CBROHION; COBALT; COPPER; IBON; LEAD;
nASNESIUH; HANGANESE; HETALS;
flOLYBDENan; NICKEL; PHOSPHORUS;
POTASSIoa; SILICON; SILVER; SODMB;
STOONTIOB; TIN; TITABIdn; VASADIOH;
ZINC; BIOACCUBULATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TOSGDE; ZIRCONIUB: ELEHESTS
Normal tissue
Autopsies
Japan
JAPAN; SDOLTS; AUTOPSIES; ADRENAL
GIAHDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LIVER; LUHGS;
LYMPH NODES; PASCREAS; SPLEEN;
STOBACB; THYROID GLANDS; TRACHEA;
ALDBINOB; BlRItJ*; CADBIOB; CALCION J
cBROBinn; COBALT; COPPER; IRON; LEAD;
HAGNESIOB; BANGANESE; BETALS;
SOIYBDENOB; NICKEL; PHOSPHORUS;
POTASSIOH; SILICON: SILVER; SOD1DB;
STEONTIUB; TIN; TITANIOB; VANADIOB;
ZINC; BIOACCOBULATIOS; HEALTH
HA7ARDS; OCCOPATIONAL HAZARDS:
TONGUE; ZIRCONIOB; ELEBENTS
formal tissue
Autopsies
Japan
JAPAN; ADULTS; AOTOPSIES; ADRENAL
GLANDS; AORTA; BONES; HEART;
INTESTINES: KIDNEYS; LIVE8; LONGS;
IYBPH NODES: PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
AIOBINDfl: BARIUB; CADBIOB; CALCIOB;
CBROBIHB: COBALT: COPPER; IRON; LEAD;
BAGN5SIOB; BANGANESE; BETALS;
B01YBDENOB; NICKEL; PHOSPHORUS;
POTASSIDfl; SILICON; SILVER; SODIDB;
STRONTIOH; TIN; TITANIOB; VANADIDB:
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TCNGOE; ZIRCONIOB; ELEBENTS
24 hr excretion after 1-2 uCi ?n-65
Estimated from graph
Significant correlation with
absorption
patients with hypogeusia and hyposmia
DISEASES; BODY; ORINE; BEASOREBENT
BETHODS; ZINC; RADIONUCLIDES; BETALS
Teraoka, H.
1981
Archives of
Environmental Health
36(K):155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(»): 155-165
OO
Teraoka. H.
1981
Archives of
Environmental Health
36 (9): 155-165
Henkin, R.I.
Aamodt, R.L.
1975
Lancet
1 (7921) : 1379-1380
-------
Zioc
74110-66-6
Zn
At« 65.38,
BP 119.5 C, BP 908 C, »P 1 » Hg at 487 C, 10 >i flg at 590 C
(CONTINUED)
TISSUE
6919
Urine
6920
Orine
ETEOSOEE ROOTE
Ingestion
1 ANALYTICAL
BETHOD
IAS
N OH BEE
or CASES
3
2
EANSE
a) 37-56 ug/24 hr
b) 286-1168 ug/24 hr
a) Hot given
b) Not given
c) Hot given
d) Not given
BEAN
a) Not given
b) Not given
a) 0.7 ig/24 hr
b) 0.7 ig/24 hr
c) 0.7 mi}/ 21 hr
d) 0.8 mg/2t hr
GHEBAL INFOBItATIOS
a) Pretreataent
b) After Zn therapy
Range of weans
2.6-12 yr old children with
acrodernati tis enteropathica
Therapy decreased irritability.
nervousness, and restlessness.
Reaission Maintained t>y 1-2
•g/kg/day.
CHILDREN; DISEASES; NOTEITIONAL
DEFICIEBCIES; BLOOD; BAIB;
INTESTIBES; SKIH; OBI HE; BETALS; ZI»C
a) Subject 1, intake 18.1 lg/24 hr.
low fiber diet
b) Subject 1. intake 19.0 «g/20 hr.
high fiber diet
c) Subject 2, intake 19.0 ig/24 hr.
low fiber diet
d) Subject 2, intake 19. » mq/21 hr.
Mgh fiber diet
Total dietary intake
Beans of 10 2-day periods
in a) and c) and CroB high fiber.
Moderate phytate local bread in b)
and d)
Both subjects in negative balance on
high fiber diet
35 and 21 yr old, wt 56.0 £ 60.3 kg.
Iran
IEAN; ADULTS; NUTRITIONAL
DEFICIENCIES; BLOOD PLASI1A; BLOOD
SERfln; OBINE; C 4 LCI OH; HAGNESIUH;
IHOSPHOBU5 ; ZINC; DIETS; FIBERS;
POODS; HETALS
BEFESEHCE
Balravens, P. A.
Hanbidge, K.K.
Neldn r, K. H.
Silve «an, A.
van D orninck, w.J.
Bier a , 6.
Favar , B.
1978
Journal of Pediatrics
93(1| :71-73
Be in ho Id, J.3.
Faradji, B.
Abadi, P.
IsiaU-Beigi, F.
1976
Journal of Nutrition
106:193-503
00
CO
Zinc 70 (No postings in CBEHLINE).
Zn
HI 65.38, BP 419.5 C, BP 908 C, vp 1 >. Hg at 487 C
TISSUE
6921
Blood,
plasia
EXPOSUEE EOOTE
Ingestion
ANALYTICAL
BETHOD
NA
NDBBI8
OF CASES
H
BADGE
Not given
BEAU
0.3%
Peak
Healt
ADOLT
BETBO
GENERAL INFOF.BATICN
Peak radioactivity, % of 3.2 mg dose
Healthy 24-37 yr olds, wt. 54-67 kg
ADULTS; BLOOD PLASBA; BEiSOBEBEBT
8ETHODS; BETALS; ZINC
Jangnorbani, R.
Ting, B.T.O.
Istfan. N.«.
Touag, v.ft.
1981
Aierican Journal of
Clinical Nutrition
34:581-591
-------
Zinc, (dihydrogen 3,7, 12,17-tetraiethyl-8,13-diriny1-2,18-pocphinedipropiocate(2-))- (8 CI|
Zinc, (7,12-diethenyl-3,8. 13,17-tetra«ethyl-21H,23H-porphine-2,18-dipropanoato(2-)-N(21) ,»(22) . N(23),N(24))-, (SP-H-2)- (9 CI)
151112-60-5
C31-H30-N1-01-Zn.2H
H8 626.03
TISSOE
6922
Blood
6923
Blood
692H
Blood
BIPOSORE E001E
ANALYTICAL
BETHOD
Fluoroietry
_ _
Fluoroaetry
NOT! BEE
OF CASES
391
1
RANGE
3-61 ug/dl
a) 12-105 ug/dl
b) 5-100 ug/dl
Not applicable
BEAM
Hot given
a) 41.2 «or- 17.0
ug/dl
b) 28.6 «or- 12.9
ug/dl
269 ug/dl
GENERAL INFORBATICN
Subjects tilth blood Pb <»0 ug/dl.
Prospective eaployees, no knovn
occupational Pb exposure
(IGOD; 9EASOBEBEHT BETHODS ; LEAD;
9ETAIS; PSOTOPORPHIEIUS; PCPOIAIIOH
EXFOSDHE
a) Cord blood
b) Maternal blood
a) significantly higher than b)
Range estiaated from graph
Bothers age 13-40 yr (Kan 21.1 yr) ,
tables nean gestational age 39.6 vk,
nean birth ut 3,211 g, indigent urban
population, K7
KESTDCKy; ACOLTS; HEHBOIK; BLOOD;
LEAD; METALS; POBPHYHIUS; ZI1IC;
BIOACCOBOIATIOH; POPOLATIOI1 EXPOSURE;
PBEGHAKCT; DRBAH AREAS
8 wk after chelation therapy (1 g
Ca»a2-EDTA 2I/day for 5 days)
Blood Pb, 103 ug/dl
»E» IORK; ACOLTS; CASE HISTORIES;
LEAD POISOHISG; BEIAL POISOHIBG;
BLOOD; DBI5E; DEOG TBEBAf V ; LEAD;
BETALS; ZIBC; HEALTH HAZARDS;
IDHALATI01I; OCCOPATIOHAL HAZARDS;
PIGB5HTS
REFERENCE
Suga, R.S.
Fischinger, A.J.
ICnoch, F.I.
1981
A>erican Industrial
Hygiene Association
Journal «2:637-6»2
Angell, K.F.
Lavery, J.P.
1982
American Journal o£
Obstetrics and
Gynecology 1K2 (1) :«0-»6
Fischbein, A.
Wallace, J.
Anderson, K.E.
Sassa, S.
Ron, 5.
Rohl, A.N.
Kappas, A.
1982
Journal of the American
Bedical Association
217(111) :2007-2009
t-0
00
VO
Zirconium
71KO-67-7
Zr
AtW 91.22, BP 1852 C, BP 3577 C
TISSUE
6925
Adrenal
gland
EIPOSORE ROOTS
ANALITICAL
BETHOD
ES
XDHBEB
OF CASES
7
BANGS
Not given
<0.4 ppB dry wt
(I EXT PAGE)
GENERAL INFOEHATION
Noraal tissue
Autopsies
Japan
JAPAX; AD0LTS; AOTOPSIES; ADHEBAL
GLANDS; AORTA; BONES; HEART;
INTESTINES; KIDNEYS; LI7BE; LONGS;
1TBPH NODES; PANCREAS; SPLIEN;
STOBACH; THYROID GLANDS; TRACBBA;
ALDBINOH; BARIOBJ CADBUJB; CALCIOH;
CBROBIOB; COBALT: COPPEE; IRON; LEAD:
HAGNESIDH; BAKGAIIESE: BKTALS:
BOLYBDENtlB; NICKEL: PHOSPHCBOS;
FOTASSIOB; SILICON: SILTEE; SODIDB;
STEONTIOB; TIN; TITANIOB; VANADIDB;
ZINC; BIOACCOBOLATION; HEALTH
HAZARDS; OCCOPATIONAL HAZARDS;
TONGOE; ZISCONIOB: ELE8ENTS
Teraoka, H.
1981
Archiies of
Environmental Health
36(11) : 155-165
-------
Zirconim
7110-67-7
zr
At» 91.22, BP 1852 C, BP 3577 C
(CONTINUED)
TISSUE
6926
fcorta
6927
Bone
6928
Heart
EIPOSDEE ROUTE
ANALYTICAL
BETHOD
IS
ES
ES
BOBBER
OF CASES
7
5
'
a) 8
b) 2
C) 3
d) 1
e) 1
BASSE
Mot given
Dot given
a) lot given
b) <0.4-<0.» pp«
c) <0.1 ppB-<0.4 ppa
d) Hot applicable
e) lot applicable
Dry vt
BEAN
<0.1 ppi dry lit
<0.1 ppi dry wt
a) <0.4 ppi
b) <0.» ppm
c) <0.» pp«
d) <0.« ppl
e) <0.4 ppa
Di^ vt
GENEHiL HPOEBATIOK
NorKal tissue
Autopsies
Japan
JAPAN; ADOLTS; AOTOPSIES; ADFCTAL
G1ANDS; AOSTA; BONES; REABT;
IHTESTIHES; KID1IEYS; LIVEE; LOBGS ;
LTBPH NODES: PAHCBEAS; SPLEEH;
STOBACH; THTBOID CLAUDS; TEACHEA;
AlOBIHOB; BABIOB; CADBIOK; CALCHH;
CBB09IOB; COBALT; COPPER; IBOM; LEAD;
BAGHESIOfl; BABGANESE; HETALS;
BCLTBDENOB; NICKEL; PHOSPHOHOS;
POTASSIOB; SILICON: SILVEB: SODIUB;
SlBOHTIOn; TIK; TITASIOB; VASADinK;
ZIBC; BIOACC0BDLATIOS; HEAITB
HAZARDS; OCCOPATIOKAL HAZABDS;
IOIIGOE; ZIBCOBI3B; E1EBEBTS
Boraal tissue
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADRENAL
GLANDS; A08TA; BONES; HEART:
IKTESTIHBS; KIDSETS; LIVES: LONGS;
LTBPH BODES; PANCREAS; SPLEEN;
STOBACH; THIEOID GLANDS; TBACHEA;
ALOIflNUn; BAEinn; CADHIOK; CALCIOH;
CBBOBIOB; COBALT; COPPER; IRON: LEAD;
BAGNESIOB; SARGANESE; HETALS;
BOLIBDEBOB: NICKEL; PHOSPHCROS;
FOTHSSlnS; SILICON; SILVER; SOOIUH;
STBONTIDH; TIN; TITA8IOB; VABADIOfl ;
ZINC; BIOSCCOBOLATIOB; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGOE; ZIRCONIUM; ELZBENTS
a) Nomal healthy men
b) Chromiui plating vorXers
d) Airplane painter
e) Stone nason
Autopsies
Japan
JAPAN; ADOLTS; AUTOPSIES; ADRENAL
GLANDS; AORTA: BONES; HEART;
IBTESTINES; KIDBETS; LIVER; LOBGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THIROID GLANDS; TRACHEA;
ALOHINDH; BJFIUS; CADBIUS; CALCIOB;
CHROHIOB; COBALT; COPPER; IRON; LEAD;
MAGNESI08; SA8GABESE; SETALS;
BOLTBDENOB; NICKEL: PHOSPHCEOS;
FOTASSIOM; SILICON; SILVER; SODWB;
STRONTIOH; TIN; TITABIOH; VABADIOB;
ZINC; BIOACCOaOLATIOB; HEALTH
HAZARDS; OCCOPATIONAL HAZABDS;
TONGOE: ZIRCONIOB; ELEBEBTS
REFERENCE
Teraolta, H.
1981
Archives of
36(«):155-165
TeraoKa, H.
1981
Archives of
36(1): 155-165
Teraoka, H.
1981
Archives of
36(1): 155- 165
_
(NEXT PAGE)
-------
Zirconium
7440-67-7
zr
At» 91.22. IIP 1852 C, BP 3577 C
(CONTINUED)
TISSUE
6929
Intestine
6930
Kidney
6931
liver
EXPOSURE ROUTE
___«_ _____ ___
ANALYTICAL
BETHOD
ES
ES
ES
SOU BEE
OF C15ES
10
a) 8
b) 2
c) 3
d) 1
e) 1
a) 9
b) 2
c) 3
d) 1
e) 1
BANGS
.
Mot given
a) Not given
b) <0.4-<0.4 pp.
c) <0.4-<0.4 pp»
d) Hot applicable
e) lot applicable
Dry wt
-
a) Not given
b) <0.4-0.76 ppm
c) <0.»-1.4 pps
d) Hot applicable
e) Not applicable
Dry wt
(NEXT
BEAN
<0.4 ppm dry wt
a) <0.4 ppm
b) <0.4 ppm
c) <0.14 ppm
d) <0.« ppm
e) <0.4 ppm
Dry wt
a) <0.t pp«
b) Not given
c) Hot givea
d) 0.46 pp«
e) 0.50 ppa
Dry vt
PA(iE)
GENEBAL IN FOE NATION
Homal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AOBTA; BOHES; HE»BT;
INTESTINES; KIDNEYS; LIVEE; LONGS;
LYBPH NODES; PANCBE1S; SPLEEN;
STOBACH; THYROID GLANDS; TBACHEt;
AlDfllNOB; BSRIOB; CADBIOB; CALCIOB;
CEBOBIOB; COBALT; COPPEB; IBON; LEAD;
BAGNESIttK; BANSANESE; BETALS;
POLTBDFNOB; NICKEL: PHOSPHOEOS;
POTASSIUB; SILICOH; SIL7EB; SODIOB;
STBOBTIDB; TIN; TITANIOB; VANACI08;
ZINC; BIOACCOnOLATION; HEALTH
HAZABDS; OCCUPATIONAL HAZAEDS;
TONGUE; ZIBCONIUR; ELEBESTS
a) Noraal healthy men
b) chronium platiog workers
c) Chromate refining workers
d) Airplane painter
e) Stone nason
Autopsies
Japan
JAPAH; ADULTS; AUTOPSIES; ADBENAL
GLANDS; AOETA; BOBES; HEABT;
INTESTINES; KIDBEYS; LI7EE; LUBGS;
LYHPH NODES; PASCEEAS; SPLEEN;
STOBACH; TBYEOIO GLANDS; TRACHEA;
ALUBINON; BAEIOB; CADBIUB; CALCIUH;
CBFOHIUH; COBALT; COPPEE; IBO»; LEAD;
HAGNESIUH; BASGANESE; BETALS;
BOLYBDENUB; NICKEL; PHOSPHORUS;
POTASSIUH; SILICON; SI17EB; SODIUB ;
STRONTIUM; TIS; TITANIUB; VANADIUB;
ZINC; BIOACCUBULATION; HEALTH
HAZABDS; OCCUPATIONAL HAZAEDS;
TONGUE: ZIBCONIUB; ELEBENTS
_
a) Normal healthy nen
b) Chroniun plating workers
c) chromate refining workers
d) Airplane painter
e) Stone nason
Autopsies
Japan
JAPAS; ADULTS: AUTOPSIES; ADBENAL
GLANDS; AORTA; BONES; HEART:
INTESTINES; KIDNEYS; LIVBB; LUHGS;
LYBPH NODES; PANCREAS; SPLEEN;
STOBACH; THYROID GLANDS; TBACHEA;
A1UHINOH; BARIUB; CADSItJH; CALCIUn;
CBROBIUB: COBALT; COPPER; IBON; LEAD;
BAGNESIDB; HANGANESE; BETALS;
BOLYBDENDB; NICKEL; PHOSPHORUS;
POTASSIUB; SILICON: SILVER; SODIUB;
SIRONTIUB: TIN: TITANIUM; VANADIUB;
ZINC; B10ACCUBULATION; HEALTH
HAZABDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUB; ELEBESTS
REFERENCE
T-eraoka, H.
1931
Archives of
Environnental Health
36(1): 155-165
Teraoka , H.
1981
Archives of
Environmental Health
36(4):155-165
Teraoka, R.
1981
Archives of
Environmental Health
36(4):755-165
S3
-------
Zirconium
7410-67-7
Zr
AtB 91.22, tl 1852 C, BP 3577 C
(CONTINUED)
TISSUE
6932
Lung
6933
lymph
node
6934
Pancreas
EXPOSURE ROUTE
ANALYTICAL
BET HOD
BS
ES
JS
NOflBEB
OF CASES
a) 12
b) 2
c* 3
d( 1
e) 1
a) 3
b) 1
c) 3
d) 1
e) 1
5
BANSE
a) Not given
b) 1.3-1.6 ppl
o) O.M-H. \ ppm
d) Mot applicable
e) Not applicable
Cry wt
__
a) Hot given
b) Hot applicable
c) 0.1-3.6 ppm
d) lot applicable
e) Not applicable
Dry wt
Not given
«EAN
a) 0.19 *or- 0. 19 ppm
b) 1.1 ppm
c) 2.1 ppm
d) 0.87 ppm
e) 5.0 ppm
Dry wt
a) 11 *or- 3.9 pp»
b) 1.7 ppm
c) 2.4 ppm
d) 6.5 ppm
e) 18 ppi
Dry »t"
<0.» pp» dry »t
SENEBAL ISFORHATIOH
a) Normal healthy len
b) chromium plating workers
c) chronate refining workers
d) Airplane painter
e) stone mason
Autopsies
Japan
JIEAH; ADULTS; AUTOPSIES; ADBENll
GLANDS; AOBTA; BONES; HEART;
INTESTINES; KIDNEIS; LIVER; LUNGS;
LYMPH NODES: PANCBEAS; SPLEEN;
STOHACH; THY.ROID GLA80S; TtUCHEA;
ALOHINOB; BARIOH; CADBIHII; CAICIBH;
CHEOBItJtl; COBALT; COPPER; IRON; LEAD;
HAGNESIUII: SANGASESE; BETALS;
noLTBDE»nn: NICKEL; PHOSPHORUS;
EOTASSItJH: SILICON; SILVER; SODIOn;
STBoNTinn: TIN; TITANIUB; VANADIDB;
ZINC; BIOACCUBOLaTION; HEALTH
HAZARDS; OCCUPATIONAL HAZARDS;
TONGUE; ZIRCONIUII; ELSHENTS
a) normal healthy men
b) Chromium plating worker
c) chromate refining workers
d) Airplane painter
e) stone mason
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; ADRENAL
GLANDS; AOBTA; BONES; HEART;
IHTESTIBES; KIDNEYS; LIVES; LONGS;
LYBPH NODES; PANCBEAS; SPLEEN;
STOBACH; THYROID GLANDS; TRACHEA;
AlOHINOB; BARIOB; CADHIUB; CAICIUB;
CBBOHICH: COEALT; COPPER; IROS; LEAD;
BAGNESIDB; BANGANESE; BETALS:
BOLTBDESUB; NICKEL; PHOSPHOBUS:
SOTtSSIBH; SILICON; SILVER; SODIUB;
STEOSTIOB; TIN; TITIKKW; VWADIOB;
ZINC; BIOACCDHOLATION; HEALTH
HAZABDS; OCCUPATIONAL HAZARDS;
TONG1E; ZISCONIUH; ELESBNTS
Normal tissue
Autopsies
Japan
JAPAN; ADULTS; AUTOPSIES; AD8ENAL
GIANDS; AOBTA; BOSES; HEART;
INTESTINES; KIDSEIS; LITER; LOHSS;
IYBPH NODES: PANCBEAS: SPLEEN;
STOBACR; THYROID SLANDS; TftftCHEA;
ALOHINUn; BAEHUB; CADBIUH; CALCIDB;
CHSOHIUK; COBUTJ COPPEB; ISDN; LIAD;
BAGNESIUB; BANSANBSE; HETALS:
BOLYBDEKUB; NICKEL; PHOSPHOBUS;
POTASSIBB; SILICOH; SILVER; SODIUB;
STRoiraiatij TIN; TITANIOB; VAHADHIK;
ZINC; BIOACCUWJLAnON; HEALTH
HAZARDS; OCCUPATIONAL HAZASDS;
TONGUE; ZIRCONIDH; ELEBENTS
Teraoka, H.
1981
Archives of
Environmental Health
36(1): 155-165
Teraoka, H.
1981
Archives of
Environmental Health
36(»):155-165
N3
\0
N>
Teraoka, H.
1981
Archives of
Environmental Health
36(1): 155-165
(NEXT PAGE)
-------
ZirconiUM
7HHO-67-7
Zr
»t« 91.22, BP 1852 C, BP 3577 c
(CONTISUED)
TISSUE
6935
Spleen
6936
Stonacb
6937
Thyroid
gland
EXPOSURE ROUTE
ANALYTICAL
BBTHOD
ES
ES
IS
RUBBER
OF CASES
a) 9
b» 2
=) 3
d) 1
e) 1
10
M
B1HGE
a) Hot given
b) 0.64-2.0 ppB
c) <0.
b) 1.32 ppM
c) Hot given
d) 1.3 ppM
e| 1.8 fpm
Dry »t
<0.4 PPM dry Ht
<0.
-------
Zircofliui
7
-------
1-Hexanol, 2-ethll-
10D-76-7
C8-H18-0
H» 130.22, BP 181-185 C
6911
Breath
EXPOSURE BOOTE
ANALTTICAL
METHOD
GC/HS
NOB BEE
OF CASES
28
BAHGE
2.2-8 ng/1
-
BEAH
4 ng/1
GENEBAL INFORMATICS
Estimated from graph
Healthy 18-60 yr olds. nonsmokers.
Rigid protocol 14 days before and
during stud; to minimize number and
aaount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORINE
ORGASIC COHPO08DS; CHtOROBEHZENES
Kjrotoszyaski, B.
Gabriel, G.
O'Neill. H.
claudio. B. P. A.
1977
Journal of
Chromatographic Science
15:239-241
1-Octene, 2-iethyl-
1588-1B-5
C9-H18
B» 126.27
6942
Breath
EXPOSnSE ROUTE
ANALYTICAL
NETHOD
GC/BS
NUHBEE
OP CASES
0.03-0.29 ng/1
0.095 ng/i
GEDERAL IHFORB»TIO»
Estimated fron graph
Healthy 18-60 yr olds, nonsvokers.
Rigid protocol 14 days before and
during study to aininize nunber and
aooont of exogenous constituents.
AD0LTS; BREATH; ALCOHOLS; CRLORIKE
ORGAHIC COHEOOKOS; CHLOROBIHZEHES
RBFERE1ICE
Krotoszynski, B.
Gabriel, s.
O'Keill, H.
Claudio, B.P.A.
1977
Journal of
Chromatographic Science
15:239-211
NJ
VO
-Pentanol, 2-ethyl-1-methyl-
06-67-2
8-H18-0
K 130.26
TISSUE
6943
Breath
EIPOSDBE ROOTE
ANALYTICAL
METHOD
GC/BS
NUMBER
OF CASES
28
BADGE
0.9-9 ng/1
2.8 ng/1
GEBERAL INFORMATION
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 14 days before and
during study to minimize number and
amount o£ exogenous constituents.
AtOLTS; BREATH; ALCOHOLS; CHLORIRE
ORGANIC COBPOOBDS; CHLOROB FSZENES
Krotos
Gabr ie
O'Neil
claudi
1977
Journa
Chroma
15:239-
-------
1-Pentanol, 2-nethyl-
105-30-6
C6-H11-0
HI 102.18, BP 148 C
TISSUE
699H
Breath
EXPOS ODE ROUTE
ANALYTICAL
BETHOD
GC/BS
N OK BEE
OF CJSES
28
BADGE
0.5-7.K ng/1
HEAD
1.9 ng/1
GENERAL INFORMATION
Estimated fron graph
Healthy 18-60 yc olds, nonsBofcers.
during study to •inisize nuiber and
anount of exogenous constituents.
ACOLTS; BREATH; AICOHOLS; CHLOEIHE
OBGASIC COHPOONDS; CH10ROBEHZENES
REFERENCE
Krotosz ynski, 8.
Gabriel, G.
O'Neill. H.
Claudio. H. P.A.
1977
Chronatographic Science
15:239-2H1
1-Pentanol, 2,2-di>ethJl-
2370-12-9
C7-H16-0
BB 116.20
TISSUE
69DS
Breath
EXPOSOBE BODTE
ANALYTICAL
METflOD
GC/BS
VDBBEE
OF CASES
28
BANGS
2-12 09/1
HE&H
K.5 ng/1
GESEEAL DlrOEH»TIO»
Estiaated fcoi graph
Healthy 18-60 yr olds* nonsnokers.
Bigid protocol \H days before and
during study to liniiize number and
anount of exogenous constituents.
ADULTS: BBEATB; AICOBOiS; CHLOBINE
OBGANIC COBPOUNDS; CHLOBOBEHZEHES
BEFEBEKCE
Krotoszynslci, B.
Gabriel, G.
0'Heill, H.
Claudio, fl.P.A.
1977
Journal of
Chroaatographic Science
15:239-2«»
1-Pentanol, 2,2,«-tri»ethyl-
123-HU-ll
C8-H18-0
B« 130
TISSUE
6946
Breath
EXFOSUBE ROUTE
AHALTTICAL
BETHOD
SC/BS
II DB BBS
or CASES
28
BADGE
2.5-10 ng/1
BEAD
5 ng/1
GE8EBAL IHFORHATIOH
Estiiated from graph
Healthy 18-60 yr olds, nonsnokers.
Bigid protocol 11 days before and
during stndy to liniiize nuaber and
anount of exogenous constituents.
ADULTS; BBE1TH; ALCOHOLS; CHLOBIHE
OBGARIC COnPOOSDS; CHLOROBESZESIS
EEFEBEMCE
Krotoszynski, B.
Gabriel, G.
O'seill, B.
Claudio, H. P. A.
1977
Journal of
chronatograpaic Science
15:239-241
-------
1-Propanol, 2,2-aimethyl-, acetate
926-m-0
C7-HU-02
BW 130.18
I TISSUE
69117
Breath
EXPOSURE ROOTS
--
ANALYTICAL
BETHOD
GC/BS
RUBBEB
Of CASES
28
BADGE
1.2-5 ng/1
BE ill
2.5 ng/1
GENERAL ISFORBATION
Estimated from graph
ADULTS; BREATH; ALCOHOLS; CBLORIBE
ORGANIC COBPOUNDS; CHLOROBENZEN ES
KrotoszynsJci, B.
Gabriel, G.
O'Neill, H.
Claudia, B.p. A.
1977
Journal of
Chromatographic Science
15:239-211 l
0.07 ug/g
Hedian
0.8 ng/il
Bedian
GENERAL ISFORBATION
Capacitor manufacture workers. 1
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASBA;
FOIYCB10SINATID BIPHEKTLS;
OCCUPATIONAL HAZARDS; MDUSTRIEs
Capacitor manufacture workers. 1976
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASBA;
EOIYCHLORIHATFD BIP HEX TLS :
OCCUPATIONAL HAZARDS; INDUSTRIES
Bolff, B.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
Solff, fl. S.
Thornton, J.
Fischbein, A.
Lilxs, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
-------
1,1'-Biphenyl, 2,2'.3.3',«,«',5-heptachloro-
35065-30-6
C12-B3-C17
BB 395
TISSOE
Adipose
6952
Blood
Blood,
plasna
E IPOS ORE RODTE
Ingestion
ANALYTICAL
METHOD
GC
HUBBER
OF CASES
a) 10
b) 9
c| 7
BADGE
..
a) Hot given
) Sot given
c) Hot given
_.
MEAD
ledlan
a) 1. 18 *or- 0.45 ppb
b) 0.28 tor- 0.09 ppb
c) 0.11 tor- 0.04 ppb
Median
GENERAL INFOBBATI05
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSDE; BLOOD PLASHA;
PCIYCHLORIHATED EIPHENYLS;
OCOJPATI08M. RiliRDS; ISDDSTEIES
a) Taiwan, PCB poisoning
t) Japan, PCB poisoning
c) Japan, controls
Few months (a) and 5 yr (b) after
ingesting contaminated rice oil.
TAIWAN; JAPAN; BLOOD; CHLORINATED
HYDROCARBONS; POIYCHLORINA TED
BIPHESYLS; BIOACCOBOLATION; FOOD
CONTAMINATION; POPULATION EKPOSDRE;
INDUSTRIAL CHESICSLS
clinical health survey. Relative
levels used to calculate
adipose- plasna partition
ADIPOSE TISSOE; BLOOD PLASflA;
POIYCHLOSIHATEB BIPHENYLS;
OCCUPATIOHAL HAZARDS; HDOSTSIES
REFERENCE
Thornton, J.
Pischbein, A.
Ulis. s.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Hasuda, Y.
Kuroki, B.
Yamaryo, T.
Haraguchi, K.
Kuratsune, n.
Hsu, S.T.
1991
Chemosphere
11(2) : 1 99-206
Thornton, J.
Fischbein, A.
Lllis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
N3
^O
oo
1,1'-Biphenyl, 2,2',3,3",0,K'.S.S'-octachloro-
35694-08-7
C12-B2-C18
fl» 429.74
TISSOE
Adipose
EXPOSOEE ROOTE
A NAUTICAL
BETHOD
NOHBEG
OF CASES
BSHGB
HEA«
GENERAL INFORMATION
clinical health survey.
ACIPOSE TISSOE; BLOOD PLASHA;
IOIYCHLORIN4TED BIPHEBYLS;
OCCDPATIONAL HAZAEDS; INDOSTRIES
REFERENCE
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
1,V-Biphenyl, 2,2', 3, 3' ,4 ,4« ,5,6'-octachloro-
12740-50-1
C12-H2-C18
fl» 429.74
TISSDE
6955
Adipose
EXPOSURE ROUTE
_
ANALYTICAL
HETHOD
GC
NDBBEB
OF CASES
26
t
RANGE
0.05-0.2 ug/g
MEAN
0. 1 ug/g
Median
GENERAL INFORMATION
Capacitor manufacture vorkers. 1976
clinical health survey. Relative
levels used to calculate
adipose- plasna partition
ADIPOSE TISSDE; BLOOD PLASBA;
P01YC8LOSIBATED BIPHENYLS;
OCCOPATIONAL HAZARDS; INDUSTRIES
REFERENCE
Wolff, M.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
(SEXT PAGE)
-------
I.l'-Biphenyl. 2,2'.3,3",4,4',5,6'-octachloro-
127*0-50-1
C12-B2-C18
MB 429.74
(CONTINUED)
TISSUE
6956
Blood,
plasma
EXPOSURE BOOTH
A NAUTICAL
METHOD
GC
D
OF
26
UnBEB
CASES
BANGE
..
0.2-1 ng/ml
BEAN
0.7 ng/nl
Median
GENEEAL IBFOBBATIOD
Capacitor manufacture workers. 1976
clinical health survey. Belative
levels used to calculate
adipose-plasma partition
JDIPOSB TISSUE; BLOOD PLASMA;
POIYCHLOBIHSTED EIPHENHS;
OCCUPATIOBH HAZARDS; IHDUSTPIES
BBFEBEDCE
«olff, M.S.
Thornton, J.
Fischbein, A.
Lllis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
1,1'-Blphenyl, 2,2',3,3',1,5,5",6'-octachloro-
52663-75-9
C12-H2-C18
(IB 429.74
TISSUE
6957
Adipose
6958
Elood,
plasma
EXPOSURE P00TE
ANALYTICAL
BETH CD
GC
GC
NUMBER
OF CASES
26
26
BADGE
0.05-0. 5 ug/g
0.2-2 ng/dl
BE AS
0.2 ug/g
Median
1 ng/ol
Med^aji
GESEEAL INFOBHATIOB
Capacitor manufacture workers. 1976
clinical health survey. Eelative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
PCLTCBLOBIHATED BIPHENTLS;
OCCDPATIONAL HAZAEDS; INDOSTRIES
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASHA;
FC1TCHLOEISSTED EIPHEHYtS;
OCCUPATIOSAl HAZAEDS; ISDDSTBIES
BEFEEEHCE
»0l£f, M.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff. I.J.
1982
Toxicology and Applied
pharmacology 62:294-306
colff, M.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
ho
VD
1,1'-Biphenyl, 2,2",3,3",4,5,6<-heptachloro-
38411-25-5
C12-R3-C17
M« 395.30
6959
Adipose
EXPOSURE BOOTS
ANALYTICAL
METHOD
GC
NONBEB
OF CASES
26
BADGE
0.05-0.2 ug/g
HEAD
0.09 ug/g
Median
Median
GENEBAL ISFOEaATION
Capacitor manufacture workers. 1976
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASMA;
FOIYCHLOEIDATED BIPHEDTLS;
OCCOPATIOSAL HAZAEDS: ISDnSTBI"S
clinical health survey.
ADIPOSE TISSUE: BLOOD PLASMA;
EOIYCHLOBINITED EIPHEBYLS;
OCC3PATIORAL HiZJBDS; IKDUSTP1BS
BEFEBENCE
Wolff, M.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Thornton, J.
Pischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
-------
1,1'-Biphenyl, 2.2',3,3'.«,5'-hexachloro-
52663-66-8
C12-H3-C17
IIS 395.30
TISSUE
6961
Adipose
6962
Blood,
plasna
.. ..
EXPOSURE BOOT!
ANALYTICAL
HETHOD
6C
6C
NOBBER
OF CiSES
26
26
BARGE
0.05-0.3 ug/g
.
0.2-2 ng/il
BEAN
0. 1 ug/g
Median
0.1 ng/Ml
Median
GENERAL INFORMATION.
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; B1OOD PIASHA;
POLYCHLORINATF.D EIPBENYLS:
OCCUPATIONAL BAZAHDS; INDUSTRIES
Capacitor nanufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasna partition
ADIPOSE TISSUE; BLOOD PLASBA;
EOLYCBLOBHATED EIPBEBItS;
OCCOPATIOKAL BAZAEDS; ISDOSTSIES
Solff, H.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Sellkoff, I.J.
1982
Toxicologv and Applied
Pharmacology 62:294-306
nolff, n.s.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1962
Toxicology and Applied
Pharmacology 62:291-306
1,1'-Biphenyl, 2,2' ,3, S'.'/S'^'-heptachloro-
J2663-70-1
C12-B3-C17
»V 395.30
TISSOE
Adipose
6964
Blood,
plasia
EXPOSaPE ROUTE
AKALyTICAL
RETHOD
GC
HOB BED
OF CASES
26
BASGE
0.2-0.5 ng/>l
BE AH
Dedian
0.4 ng/il
Median
GESEBAL IHFOBBATIOH
clinical health survey.
ADIPOSE TISSUE; BLOOD PIASHA;
iOIYCH10BI»ATED BIPBEHYLS;
OCCOPATIOBAI H1ZJRDS; IKOOSTBIES
Capacitor Manufacture workers. 1976
clinical health survey.
ADIPOSE TISSOE; BLOOD P1ASB»;
P01TCH10BIBA1ED BIPHIHHS;
OCCUPATIONAL BAZABDS; ISDOSTBIES
REFERENCE
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Wolff, B.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selitoft, I.J.
1982
Toxicology and Applied
Phariacology 62:294-306
o
o
1,1'-Biphenyl, 2,2',3,4-tetrachloro-
52663-59-9
C12-B6-C14
n« 291.98
TISSUE
6965
Adipose
EIPOSDBE ROUTE
ANALYTICAL
METHOD
GC
IUHBEB
OF CASES
26
EAHGE
0.04-3 ug/g
BEAS
0.3 u«/g
aedian
GENERAL INFORBJTIOH
Analytically indistinguishable froa
3,5,3',5'-tetrachlorobiphenyl
Capacitor nanufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasaa partition
ADIPOSE TISSOE; BLOOD PJ.ASBA;
fOIICHLOEINATID EIPBEHYLS;
OCCUPATIONAL BAZARDS; IHDUSTBIES
Holff, B.S.
Thornton, J.
Fischbein, A.
Lilis. R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
(HEXT PAGE)
-------
l.l'-Biphenyl, 2,2',3,4-tetrachloro-
52663-59-9
C12-H6-C14
81 291.98
(COHTISOED)
6966
Blood,
plasma
EXPOSURE BOOTE
ANALYTICAL
METHOD
HIM BEE
OF CASES
26
E1HGE
0.2-12 ng/ml
MEAD
1 ng/ml
Median
GENERAL INFORMATION
Analytically indistinguishable from
3, 5, 3 • , 5 • -tetrachlorob iphe nyl
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASMA;
EOIYCHLOBIHATED BIPBESYtS;
OCCUPATIONAL HAZABDS; IHDUSTBIES
BEFEBENCE
Wolff. U.S.
Thornton* J.
Fischbein. A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62: 29*- 306
1,1'-Biphenyl, 2,2' .3,
35065-29-3
C12-H3-C17
«« 395
.5,5'-heptachloio-
TISSUE
6967
Adipose
6968
Blood
Blood,
plasma
EXPOSURE ROUTE
Ingestion
ANALYTICAL
METHOD
GC
GC
SUBEES
or CJSES
26
a) 10
b) 9
BADGE
0.05-3 ug/g
.
a) Hot given
) Hot given
HEAD
0.6 ug/g
Median
a) 1.73 +or- 0.63 ppb
b) 0.44 +or- 0.15 ppb
Median
SEHESAL IHFOB»ATIOH
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels osed to calculate
adipose-plasma partition
ADIPOSE TISSDE; BLOOD PLASBA;
POiyCHLOBIHATED EIPHEHUS;
OCCOPAT10HAL HAZABDS; IHDOSTEIES
a) Taiwan, PCB -poisoning
b) Japan, PCB -poisoning
Fe» months (a) and 5 yr (b) after
ingesting contaminated rice oil.
TAIBJH; JAFIN; BLOOD; CHLORINATED
HYDROCAPBOHS; POLYC HLOBIHATED
EIPHEHYIS; BIOACCOHOLATIOH; FOOD
CCKTJBISATIOil; POPOIATIOH EXPOSDBE;
IHDOSTB1AL CHEMICALS
clinical health survey. Relative
levels used to calculate
adipose- plasma partition
ADIPOSF TISSUE: BLOOD PLASMA;
PCIYC HLOBIHATED BIPHEHYLS;
OCCDPATIOHAL HAZARDS; IHDOSTBIES
BEFEREHCE
SOlff, B.S.
Thornton, J.
Fischbein, A.
Lilis, a.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Hasuda, Y.
Kuroki, H.
Raraguchi, ft.
Kuratsune, n.
Hsu, S.T.
1931
Chemosphere
11 (2) : 199-206
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology aad Applied
Pharmacology 62:294-306
I.l'-Biphenyl, 2,2',3,4,4',5'-hexachloro-
35065-28-2
C12-B4-C16
KW 361
Tissas
Uipose
ETPOSORE ROaTB
ASAIYTICIL
METHOD
»0«BEE
OF CASES
BINGE
0 06 4
_
«2i»
Median
GEHEBAL INFORMATION
clinical health survey. Belative
levels used to calculate
adipose-plasma partition
ADIPOSf TISSUE; BLOOD PLASMA;
POIYCHLORIN1TED BIPHESYLS;
OCCOPATI08AL HAZABDS; INDUSTRIES
REFEREHCB
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
(NEXT PAGE)
-------
1,I'-Biphenyl, 2.2',3,0,4',5'-hexachloro-
35065-28-2
C12-H4-C16
B« 361
(CONTINUED)
Blood
6972
Blood,
plasia
EXPOSURE ROUTE
Ingestlon
ANALYTICAL
BBTHOD
GC
_
GC
NUMBER
or CASES
a) 10
b) 9
0) 7
26
BANGS
a) Hot given
) Hot given
c| Not given
0.5-17 ng/ml
BE4H
a) J4.66 tor- 1.43 ppb
b) 0.65 »or- 0.21 ppb
c) 0.17 tor- 0.07 ppb
4 og/al
Seaian
- -
GENERAL INFORMATION
a) Taiwan, J?CB poisoning
fc) Japan, PCB poisoning
c) Japan, controls
Few nonths (a) and 5 yr (b) after
ingesting contaminated rice oil.
TAIHAN; JAP UN; BLOOD; CHLORINATED
HYDROCARBONS; POLYCHLOEINATEO
BIPHESY.LS; BIOACCDBULATI011 ; FOOD
CCSTABINATION; POPULATION EXPOSURE;
INDUSTRIAL CHEMICALS
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
POLTCHLORINATED BIPHENILS;
OCCUPATIONAL HAZARDS; INDUSTRIES
KEfERBNCE
nasuda, I.
Kuroki, H.
Yauaryo, T.
Haraguchi, K.
Kuratsune, n.
Hsu, S.T.
1981
Cheaosphere
11 (2) : 199-2 06
BOlff, tl.S.
Thornton, J.
Pischbein, A.
Lilis, S.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
I.l'-Biphenyl, 2, 2* .3,
-------
1,I'-Biphenyl, 2.2',3,0,S'-pentachloro-
38380-02-8
C12-H5-C15
tt 326.12
(CONTINUED)
TISSUE
BlOOd,
plasna
EXPOS0BE ROUTE
ANALYTICAL
METHOD
NUflBBR
OF CASES
8ANGE
(IE A 8
Median
.
GENERAL IWFOPHATIOH
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASKA;
EOIYCHLORIHATZD BIPHENYLS;
OCCUPATIONAL HAZARDS; ISDOSTRIES
REFERENCE
Thornton, J.
Pischbein, A.
Lilis. S.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
I.l'-Blphenyl. 2,2' .3, »• ,5,5'-hexachloro-
51908-16-8
C12-BH-C16
B« 360.66
TISSUE
6977
Adipose
6978
Elood,
plasma
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC
GC
HOB BEE
OF CASES
26
26
BANGE
0.05-0.7 ug/g
0.2-2 ng/ml
BEAN
0.1 ug/g
Median
0.7 ng/Bl
Median
GENERAL ISFOPMATION
Capacitor manufacture workers. 1976
clinical health survey. Relative
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASMA:
POIYCHLCBIIIATED EIPHEBYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
EOLYCHLORINATED BIPHESYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
REFERENCE
Solff, M.S.
Thornton, J.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
Bolff, M.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
UJ
o
u>
l,l'-Biphenyl, 2,2",3,1',5,5',6-heptachloro-
52663-68-0
C12-H3-C17
H« 395. 30
TISSUE
Adipose
Blood,
plas»a
EXPOSURE ROOTE
AHAITTICU
METHOD
.
HOflEER
OF CASES
BINGE
-
0.2 2 ng/ml
BEAN
Median
Median
GENERAL INFORMATION
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
POIYCBLORINATED BIPHENYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASMA;
POIYCHLORINATED BIPHESYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
REFERENCE
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
»9B2
Toxicology and Applied
Pharmacology 52:291-306
Thornton/ J,
Fischbein, A.
Lilis, fi.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:29»-306
-------
l,l'-Biphenyl, 2,2',3,5,5'-pentachloro-
52«63-61-3
C12-B5-C15
nil 326.42
TISSUE
Adipose
6982
Blood,
plasna
EXPOSURE ROOTS
ANALYTICAL
BETHOD
.
GC
SOB BEE
OP CASES
.
26
BINGE
0.6-2 ng/ml
BEAU
fledian
0.9 ng/ml
Median
GENERAL INFOKHATION
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASMA;
POLYCHLOEIHATED BIPBEHYLS;
OCCUPATIONAL BAZABDS; INDUSTRIES
Capacitor manufacture* workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
POIYCBLOBINATED BIPBEHYLS:
OCCUPATIONAL BAZAEDS; INDUSTRIES
REFERENCE |
'
Thornton, J.
Fischbein, A.
Li Us, 8.
Selikoff, 1.3.
1982
Toxicology and Applied
Pharmacology 62:291-306
Holff, U.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
1,1'-Biphenyl, 2,2' ,3,5'-tetrachloro-
1114611-39-5
C12-B6-C14
n» 291.98
TISSUE
6993
Adipose
6981
Blood,
plasma
EXPOSURE ROUTE
A NAUTICAL
HETHOD
GC
6C
N OB BEE
OF CASES
26
26
ESNGE
0.1-5 ug/g
0.4-55 ng/«l
HEAN
0.5 ug/g
Hedian
-
3 ng/il
Dedian
GENERAL INFOBBATION
Capacitor nanufactnre workers. 1976
clinical health survey. Relative
concentrations used to calculate
adipose-plassa partition
AETPOSE TISSUE! BLOOD PLASKA;
POLYCBLORINATED EIPBESTLS;
OCCUPATIONAL BAZABDS; INDUSTRIES
Capacitor manufacture workers. 1976
clinical health survey. Belative
concentrations used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASHA;
P01TCBLOBIBATED BIPHENILS;
OCCUPATIONAL BAZABDS; INDUSTRIES
Holtf. H.S.
Thornton* J.
Fischbein, A.
lilis, B.
Selitoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Uoltf, U.S.
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
1.1'-Biphenyl, 2,2', 3, 5',6-pentachloro-
36379-99-6
C12-B5-C15
R« 326.42
TISSUE
6985
Adipose
EXPOSURE ROUTE
ANALYTICAL
HETBOD
—
GC
NOIIBEfi
OF CASES
. -
26
BANGE
0.05-2 ug/g
BE AH
0.2 ug/g
Median
GENERAL IKFOBnATION
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASMA;
P01ICHLORIBATED EIPHEHYLS;
OCCUPATIONAL BAZARD'S; INDUSTRIES
So Iff, B.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
(NEXT PAGE)
-------
1 ,V-Biphenyl, 2,2'.3,5*, 6-pentachloro-
38379-99-6
C12-H5-C15
B» 326.42
(CONTINUED)
TISSOE
Blood.
plasna
EXPOSORE POOTE
ANALYTIC*!
HETHOD
HOB BBS
OF CASES
BANGS
UAN
Median
SENBBiL INFOSBATIOH
clinical health survey. Relative
levels used to calculate
adipose-plasia partition
ADIPOSE TISSUE; BLOOD PLA5BA;
rolYCHLOSIHATED EIPHESYLS;
OCCOPATIOHAL HAZARDS; IHDOSTBtES
BEFEBE.1 CS
Thornton, J.
Fisohbeln. A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Phar»acology 62:294-306
I,l'-Eiphenyl, 2,2',1,1',5-pentachloro-
38380-01-7
C12-H5-C15
fl« 326.142
TISSOE
«9B7
Adipose
6988
Blood,
plasaa
EXPOSURE 800TE
ANALYTICAL
BETHOD
GC
GC
NOtlBEB
OF CASES
26
26
BANGE
0.07-5 ug/g
0.4-12 ng/»l
HEAD
1 ug/g
Kedian
4 ng/ll
Bedian
GESEBAL IHFOBHATIOB
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasaa partition
ADIPOSE TISSUE; BLOOD PLASHA;
POIYCHLOBIMATED BIPHEHYLS;
OCCnPATIOKJL HAZABDS; IHDOSTBIES
Capacitor aanufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasia partition
ADIPOSE TISSUE; B10OD PLASflA;
POLYCHLOBIHATED BIPHEHYtS;
OCCOPATI01I1L HAZARDS; IBDOSTBIES
Bolff, U.S.
Thornton, J.
Fischbein, A.
Hiis. B.
Selikoff, I.J.
1982
Toxicology and Applied
Phar«acology 62:29»-306
Bolff, a.s.
Thornton. J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Phareacology 62:291-306
1,1'-Biphenyl, 2,2',1,»',5,5'-hexachloro-
3E065-27-1
C12-H»-C16
ns 361
6989
Adipose
6990
Blood
EIPOSUBE BOOIE
Ingestion
ANALYTICAL
BETBOD
SC
GC
Htm BEE
OF CASES
26
a) 10
b) 9
c) 7
RANGE
0.09-1 ug/g
a) Hot given
) Mot given
c) Hot given
(NEXT
(IE AH
1 ug/g
Kedian
a) 2.51 +or- 0.96 ppb
b) 0.52 *or- 0.22 ppb
c) 0.15 +or- 0.07 ppb
PAGE)
GENERAL ISFORBHTIOH
Capacitor manufacture workers. T976
clinical health survey. Relative
levels used to calculate
adipose-plasia partition
ADIPOSE TISSUE; BLOOD PLASKA;
POIYCBLORI8ATED BIPHENYLS;
OCCUPATIONAL HAZARDS; IHDUSTRIES
a) Taiwan, PCB poisoning
b) Japan, PCB poisoning
c) Japan, controls
Few «onths (a) and 5 yr (b) after
ingesting contaminated rice oil.
TAI9AH; JAPAN; BLOOD; CBLOBIHATED
HYDPOCABBOHS; POLYCHLOBINATED
BIPHEHYLS; BIOACCUBULATIOH; FOOD
CCHTABINATIOH; POPULATIOH EXPOSURE:
INDUSTRIAL CHEHICALS
BEFERESCE
Kolff. B.S.
Thornton, J.
Fischbein, A.
Lilis. R.
Selikoff. I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Basuda, Y.
Kuroki, R.
Yanaryo, T.
Haraguchi, K.
Kuratsnne, H.
Hsu, S.T.
1981
CheBOSphere
11 (2) : 199-206
-------
1,1'-Biphe»yl, 2.2' ,1, 1',5,5'-hexachloro-
3J065-27-1
C12-BU-C16
»« 361
(CONTIH'JED)
TISSOE
6991
Blood,
plasma
EKEOSORE ROUTE
ANALYTICAL
KETROD
GC
NOHBEB
OF CASES
26
BADGE
0.7-12 ng/ml
5 ng/ml
Median
GENEBAL INFORMATION
capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSOE: BLOOD PLASMA;
POLYCBL08IHATED EIPBENYLS:
OCCUPATIONAL HAZABDS; INDOST8IES
Bolff, U.S.
Thornton, J.
Fischbein, A.
Lilis, 8.
Selikoff, 1.3.
1982
Toxicology and Applied
Pharmacology 62:291-306
I.l'-Biphenyl. 2,2' ,»,5,5'-pentachloro-
37680-73-2
C12-B5-C15
ns 326.42
IISSDE
6992
Adipose
Blood,
plasia
EICOSDRE HODTE
ANALYTICAL
HETHOD
GC
NOBBBB
OF CASES
26
BAHCE
0.07-0.5 ug/g
.
HE IN
0. 1 ug/g
nedian
Median
..
GEMEfiAL ISFOEBATI01I
Capacitor nanufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plas«a partition
ADIPOSE TISSOE; BLOOD PLASMA;
POIYCBLOBIBATED BIPHEBYLS;
OCCOPATIOBAL BAZAEDS; IBOOSTEIES
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASHA;
POIYCHLOEIHATED BIPBEHYLS;
OCCOPAIIOHAL BAZAEDS; ISDOSTBIES
REFERENCE
Wolff, U.S.
Thornton, J.
Fischbein, A.
Lilis, E.
Selikoff, 1.3.
1982
Toxicology and Applied
Pharmacology 62:291-306
Thornton, J.
Fischbein, A.
Lilis, E.
Selikoff, 1.3.
1982
Toxicology and Applied
Pharmacology 62-. 29H-306
I.t•-Biphenyl, 2,2',1,5'-tetrachloro-
1111611-110-8
C12-B6-C11
BV 291.98
TISSOE
Adipose
6995
Blood,
plasma
ET.COSHBE BOtlTE
.._
ANALYTICAL
flETHOD
GC
HOHBEB
OF CASES
.
26
BASSE
. . .
0.2-12 ng/ml
HE AS
Median
2 ng/nl
Median
.
GENEEAL INFOBBATION
clinical health survey. Relative
concentrations used to calculate
adipose-plasma partition
ADIPOSE TISSOE: BLOOD PLASMA;
PCIYCHLOSIHATED BIPHEHYLS:
OCCUPATIONAL HAZABDS; INDUSTRIES
Capacitor manufacture workers. 1976
clinical health survey. Relative
concentrations used to calculate
adipose- plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
POIYCHLOBINATED BIPBEHYLS;
OCCUPATIONAL HAZARBS; I»DOSTRIES
R
Thornton
Fischbei
Lilis, B
Selikoff
1982
Toxicolo
Pharmaco
Holff, II
Thornton
Fischbei
Lilis. B
Selikoff
1982
Toxicolo
Pharmaco
-------
1,1'-Biphenjl. 2,2',5,5'-tetrachloro-
•S693-99-3
C12-B6-C14
B« 291.98
TISSUE
Adipose
6997
Blood ,
plasma
El POSH BE ROUIE
ANALYTICAL
8ETHOD
GC
N UB BEE
OF CASES
_.
36
BADGE
...
0.5-23 ng/ml
.
BEAN
...
fledian
4 ng/ml
Bediaa
GENERAL INFORBATIOH
clinical health survey. Relative
concentrations used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PL1SBA;
POIYCHLORINATED EIPHENYLS;
OCCUPATIONAL HAZARDS ; INDUSTRIES
Capacitor manufacture workers. 1976
clinical health survey. Relative
concentrations used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASHA;
POIYCHLORINiTED EIPHEHYLS;
OCCUPATIONAL HAZARDS: INDUSTRIES
_
REFEBBSCE
Thornton, J.
Fischbein, A.
Lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Wolff, H.S.
Thornton, J.
Fischbein, A.
Lilis, B.
SeliXoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
1,1'-Biphenyl, 2, 3, 3',»,»' ,5-hexachloro-
38380-08-4
C12-H1-C16
XV 361
TISSUE
6998
laipose
Blood
Blood,
EXPOSUBE BOUTE
AHALTTICAL
HETHOD
GC
N D« BEE
Of CASES
26
b) 9
C| 7
-
BASGE
0.08-2 ug/g
) Hot given
c) Hot given
-
KEAN
0.4 ug/g
Median
b) 0.28 tor- 0.07 ppb
c) 0.04 tor- 0.02 ppb
Median
GENERAL INFORBSTIOH
Capacitor manufacture uorkers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE: BLOOD PLASMA;
POITCHLOfilSATED BIPHEHYLS;
OCCUPATIONAL BAZABDS; INDUSTRIES
t) Japan, PCB poisoning
c) Japan, controls
Few months (a) and 5 yr (b) after
ingesting contaminated rice oil.
T»I«MI; JAP18; BLOOD; CRWHIBAT5D
HYDROCARBONS; POLYCHLORIHATED
BIPHENYLS; BIOACCOBOLATIOS; FOOD
CONTABINATION; POPULATION EXPOSURE:
INDUSTRIAL CHEBICALS
clinical health survey. Belative
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
EOLYCHLORISATED EIPHENYLS;
OCCUPATIONAL HAZABDS; INDUSTEIES
BEFEBENCE
Wolff, B.S.
Thornton, J.
Ftschbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
Kuroki, H.
Yamaryo, T.
Haraguchi, K.
Kuratsune, B.
Hsu, S.T.
1981
C hem osp here
11 (2): 199-206
Thornton, J.
Lilis, R.
Selikoff. I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
-------
l.V-Biphenyl, 2,3, 3',t,5,5'-hexachloro-
39635-35-3
C12-B4-C16
B» 360.86
TISSUE
7001
Adipose
7002
Blood,
plasma
EXPOSURE ROUTE
_
ANALYTICAL
METHOD
_.
GC
GC
NOBBEB
OP CASES
26
26
BINGE
0.05-1 ug/g
0.4-4 ng/ml
0.3 ug/g
Median
1 ng/ml
Median
GENERAL INFORMATION
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
POLYCHLORINATED BIPHENYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
Capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASBA;
POLYCHLORINATED BIPHENYLS;
OCCUPATIONAL BAZ1EDS; ISDUSTRIES
»0lf£, U.S.
Thorntonv J.
Fischbein, A.
Lilis. R.
Selikoff. 1.3.
1982
Toxicology and Applied
Pharmacology 62:294-306
Solff. M.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff. I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
1, V-Biphenyl, 2,3,3*f<*1 ,5-pentachloro-
70H2I4-68-9
C12-B5-C15
US 326.112
TISSUE
7003
Adipose
7004
Blood,
plasma
EXPOSURE ROUTE
ANALYTICAL
flETHOD
GC
OC
IDHBER
OF CASES
26
._
26
BADGE
._
0.09-0.2 ug/g
0.4-1 ng/«l
DEAD
0. 1 ug/g
Hedian
0.6 ng/il
aedian
GENERAL IHFORBATIOD
Capacitor manufacture workers. 1976
clinical health survey.
ADIPOSE TISSUE; BLOOD PUS HA;
POLTCHL08I1I1TED BIPHESILS;
OCCOPATIOKAL HAZABDS; IHDDSTRIES
Capacitor manufacture workers. 1976
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASBA;
FOiyCHLORISATED BIPHBHILS;
OCCUPATIONAL HAZARDS; INDUSTRIES
REFERENCE
Wolff, B.S.
Thornton, J.
Fischbein. A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and
Applied
Pharmacology 62:294-306
wolff, B.S.
Thornton, J.
Fiscbbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and
Pharmacology 62
Applied
: 294-306
O
O3
1,1f-Biphenyl, 2,3,3',4»,6-pentachloro-
36380-03-9
C12-B5-C15
a« 326.42
TISSUE
7005
Adipose
EXPOSURE ROUTE
AIALITICAL
SETHOD
GC
HUB BEE
OF CASES
26
BAHGE
0.07-0.3 ug/g
BEAB |
1
1
1
0.1 ug/g 1 An
Median I 3,
1 ca
1 cl
1
1 AD
1 PO
1 OC
1
GEKBBAL INFORBATICH
Analytically indistinguishable from
3,4,3',4'-tetrachlorobiphenyl
Capacitor manufacture workers. 1976
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASHA;
POLYCHLORIHATED BIPHENILSJ
OCCUPATIONAL HAZARDS; IHDUSTBIES
(MBIT PAG?)
wolff, a.s.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
-------
1,1'-Biphenyl, 2,3, 3',1',6-pentachloro-
383BO-03-9
C12-H5-C15
B« 326.12
(COVTIHVED)
TISSUE
7006
plasma
EIPOSDKE EOOTE
ANALYTICAL
BETHOD
GC
I OH EBB
OF CASES
26
BAIGE
__
0.3-3 ng/ml
BEAN
0.5 ng/ml
GENERAL INFORBATION
Analytically indistinguishable from
Capacitor manufacture workers. 1976
clinical health survey.
ADIPOSE TISSUE; BLOOD PLASnlj
POLYCBLOBINATED BIPHENYLS;
OCCUPATIONAL HAZARDS; INDUSTRIES
REFERENCE
Wolff, n.S.
Fischbein, A.
Liiis, R.
Selikoff. I.J.
1982
Toxicology and Applied
Pharmacology 62:291-306
1,1'-Biphenyl, 2,3',", »• ,5, 5'-heiachloto-
52663-72-6
C12-H8-C16
a« 360.66
TISSUE
7007
Sdipose
7008
Blood,
plasia
ETPOSD8E ROUTE
AIALITICAL
BETHOD
..
6C
GC
HOUBEB
OF CASES
26
26
BAMGE
0.05-0. it ug/g
0.2-2 ng/«l
HEAB
0.1 ug/g
Median
0.5 ng/il
Hedian
GESEBAL I»rOEfl»TIO»
Capacitor nanufacture uorkers. 1976
clinical health survey. Relative
adipose-plasaa partition
ADIPOSE TISSDE; B100D PIASHA;
EOIYCHLORINATED BIPHEHYLS;
OCC0PATrO»AL HAZABDS; ISDOSTEIES
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BIOOD PIASBA;
POITCHLORISATED BIPHEBILS;
OCCUPATIONAL HAZABDS; ISDOSTRIES
REFEREHCE
. .
wolff, x.s.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
19B2
Toxicology and Applied
Pharmacology 62:29^-306
Wolff, n.s.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:29«-306
OJ
o
VO
l,1'-Biphenyl, 2,1,t'-trichloro-
7012-37-5
C12-H7-C13
KH 257.5»
TISSUE
7009
Adipose
7010
Blood,
plasna
EXPOSOEE ROUTE
A8ALTTICAL
BETBOD
GC
SC
_.
IOBBEB
OF CASES
26
26
KAHGE
0.5-183 ug/g
1-850 ng/>l
-
BEAN
9 ug/g
aedian
27 ng/al
nedian
GEHEHAL IHFOBBATIOH
Capacitor nanufacture workers. 1976
clinical health survey. Relative
concentrations used to calculate
adipose-plasna partition
ADIPOSE TISSUE: BLOOD PLASRA;
POLYCHLOBIHATED BIPHESYLS;
OCCUPATIONAL BAZABDS; INDUSTRIES
Analytically indistinguishable frog
2,5, Uf-trichlorobiphen yl
Capacitor manufacture workers, 7976
clinical health survey
Relative concentration used to
calculate adipose-plasna partition
ADIPOSE TISSUE; BLOOD PLASflA;
FOIYCHLORISATED EIPBENTLS;
OCCUPATIONAL BAZABDS; INDUSTRIES
Wolff, U.S.
Thornton, J.
Fischbein, A.
Lilis, R.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:29»-306
Wolff, U.S.
Thornton, J.
Fischbein, A.
Lilis, R.
selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:29*-306
-------
1,1'-Biphenyl, 3,3' ,4,5'-tetrachloro-
4 W1-18-6
C12-H6-C14
«« 291.98
TISSDE
7011
id i pose
7012
Blood,
plasma
EXFOSOBE HOOTE | ANALYTICAL
BETHOD
GC
ac
NOflBBB
OP C1SES
26
26
BiNGB
0.03-6 ug/g
0.7-29 ng/ml
KEiN
0.9 ug/g
3 ng/ml
Median
1
GENERAL IN FOE HA TICK
Analytically indistinguishable from
2 . 3, H ,1 ' -tstrach lorobi phen yl
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
ADIPOSE TISSUE; BLOOD PLASHA;
POLYCBLOBIHATED BIPHENILS;
OCCUPATIONAL HAZARDS; INDOSTBIES
Analytically indistinguishable fro*
2,3,4,4'-tetrachlorobiphenyl
capacitor manufacture workers. 1976
clinical health survey. Relative
levels used to calculate
adipose-plasma partition
JDIPOSP TISSDE; BLOOD PLASM;
POIYCBLOHINATED EIPHENYLS;
OCCUPATIONAL BAZAEDS; IKDDSTEIES
BEFEBEHCE
Wolff, M.S.
Thornton, J.
Lilis, B.
Selikoff, I.J.
1982
Toxicology aad Applied
Pharmacology 62:291-306
BOiff. 9. S.
Thornton, J.
Fischbein. A.
lilis, B.
Selikoff, I.J.
1982
Toxicology and Applied
Pharmacology 62:294-306
,2-Benzisothiazolin-3-one. 1,1-diozide (8 CI)
t2-Benzisothiazol-3(2H)-one, 1,1-dioxide (9 CI)
81-07-2
C7-B5-K-03-S
n» 183.2, BE 228 c (decomp) , BP (sublimes)
1 TISSOI
7013
Blood,
plasma
701»
Blood,
plasma
EIPOSOBE ROUTE
Ingestion
Injection
Ingestion
IH1LTTICU
nETBOD
BPLC
BPIC
Houses
OF C1SES
a) 3
b) 1
c) 2
3
BINGE
a) 1 120-2 156 ng/ml
b) Hot applicable
c) 550-575 ng/ml
a) 75-0.1 ug/ml
b) 80-1.2 ug/ml
c) 27-O.O ug/ml
d) 1«-<1.0 ug/ml
HE AS
a) 1533 cg/ml
b) 983 ng/ml
c) 562 ng/al
a) Not given
b) Not given
c) Not given
d) Not given
GENERAL ISPOBMATIOB
a) Peak level 0.5-1.0 hr after 75
mg/6 hr, area under the
concentration-time curve (ADC) ,
113.6-69.1 ng hr/ml
b) Peak level 0.5 hr a«ter 50 mg/6
hr, tOC, 41.1 ng hr/ml
c) peak level 0.5 hr after 25 mg/6
hr, ADC, 41.2-62.1) ng hr/ml
Dose given 4x/day for 3 days prior to
measurement
27-43 yr old (mean 32) , >t 54-96 kg
(mean 74), normal subjects, used
saccharine regularly
ADULTS; BLOOD PLASBA; (JRIHE; FOOD
ADDITIVES; SWEETENING »GE»TS
. _. .
a) 5 and 400 min after 10 ig/V.q IT
bolus
b) Same as a], plus SOO mg profcenecid
12 and 2 hr before and 2 hr after
saccharin
c) 0.5-1.0 and >25 hr hr after 2.0 g
oral, after overnight fast
d) 1.5-2 aad >25 nr after 2.0 g oral.
1-2 hr after a meal
Range of means, estimated from graph
25-37 yr olds, lit 77-1J6 kg, oeited
Kingdom
EIOOD FLASS1; OBI KB; COBPARATII'Z
EVALUATIONS; FOOD iDDITITES;
SV FETCHING AGEHTS; OBI TED KINGDOB
(SBIT PAGE)
Colburn, H.A.
Bekersky, I.
Blumenthal, a. P.
1981
Clinical Pharmacology
and Therapeutics
30(4):558-563
Sweatman, T.w.
Benvick, t.G.
Burgess, C.D.
1981
Xenobiotica
11(81:531-540
LO
I-1
O
-------
1,2-Benzisothiazolin-3-one, 1,1-dioxide (8 CD
1,2-Benzisothiazol-3(2H)-one. 1,1-dioxide (9 CI)
61-07-2
C7-H5-H-03-S
«» 183.2, tit 228 C (decomp) , BP (sublimes)
(COHTHOED)
TISSUE
7015
Blood,
plasma
7016
Ortne
7017
Orine
7016
EXPOSOBE BOUTE
Ingestion
Ingestion
Ingestion
Ingest ion
AHALITICAL
METHOD
GC/«S
BPLC
8PLC
ec/Ms
HOTBEB
OF CASES
«) 5
b) 5
c» 5
a) 3
b) 1
c) 2
3
a| 5
b) 5
c) 5
B1HGB
a) 1.83-0.5 ug/ml
b) 9.34-1.5 ug/nl
c) 13.77-2.0 ug/ml
a) 77-105 ug
b) Hot applicable
c) 32-3» ig
a) 86.0-91.3* of dose
b) 81.7-83.5* of dose
c) 98. 6-105. 3* of dose
d) 97.2-100.7% of dose
a) Hot given
b) Hot given
c) Hot given
HEAH
a) Hot given
b) Hot given
c) Hot given
a) 91 ig
b) 75 mg
c) 33 mg
a) 89.2 »or- 7.8* of
dose
b) 86.2 tor- 3.9% ot
dose
c) 101. 1 *or- 3.6* of
dose
d) 98.9 »or- 1.8* of
dose
a) 16.7 ig
b) 124.1 mg
c) 265.3 »g
GEHEKAL ISFORBSTIOH
a) 50 19/60 kg
b) 150 mg/60 kg
c) 333 oq/60 kg
30-60 and 240 Bin after dose. Levels
at 5 Bin, < 2 og/«l
Range of means, soae levels estimated
frci graph
Health; volunteers
BLOOD PLkSIU; DEINE; S1EETENING
iGEHTS
a) 75 mg/6 hr
b) 50 mg/6 hr
c) 25 »g/6 hr
Doses given Ix/day for 3 days prior
to Measurements
Excreted 0-6 hr after last dose
27-H3 yr old (mean 32) , vt 5K-96 kg
(nean 74), normal subjects, used
saccharine regularly
ADULTS; BLOOD PLASKA; UBIHE; FOOD
ADDITIVES; SHEETEHIHG AGENTS
a) 0-96 hr after 2. 0 g oral, after
overnight fast
b) 0-96 hr after 2.0 g oral, 1-2 hr
after meal
c) 0-48 hr after »0 eg/kg 17
d) same as c) plus 500 mg probenecid
12 and 2 hr before and 2 hr after
saccharin
25-37 yr olds, vt 77-126 kg. United
Kingdom
ELOOD PLASHA; OBINE; COMPARATIVE
EVALUATIOHS; FOOD ADDITIVES;
S9EETESIHS AGESTS; DSITED KINGDOM
a) 78.0% of 50 ag/60 Kg dose
b) 74.0* of 150 mg/60 kg dose
c) 74. 9* of 333 mg/60 kg dose
Cumulative 24 hr output
Healthy volunteers
BLOOD PLASHA; UBIBE; SWEETENING
AGENTS
BEFEBEHCE
Pantarotto, c.
Salmona, n.
Garattini, s.
1981
Toxicology Letters
9:367-371
Colburn, «.A.
Bekersky, I.
Blumenthal, H. P.
1981
Clinical Pharmacology
and Therapeutics
30(4) ; 558-563
Sweatman, T.ff.
Benwick, A.G.
Burgess, c. D.
1981
Xenobiotica
11 (8):531-540
Pantarotto, c.
Salmona, n.
Garattini, s.
1931
Toxicology Letters
9:367-371
-------
1,3-cycloheptadiene (no postings in CHEBLINE).
C7-H10
HB 911.16, BF 120-121 C
TISSOS
7019
Breath
EXPOSOBE ROOTS
ABALTTICAL
HETHOD
SC/SS
N OH BEE
OF CASES
28
BINGE
0.05-0. 21 ng/1
DEAN
0. 12 ng/1
GEIIEBAL IHFOBHATIOH
Estiaated fron graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 111 days before and
during study to minimize number and
amount of exogenous constituents.
ADOLTS; BBEATH; ALCOHOLS; CHIOEIHE
OBGASIC COHPOOHDS; CHLOROBESZEHES
Krotoszynski, B.
Gabriel, G.
O'Beill, H.
Claudio, H.P.A.
1977
Journal of
chromatographic Science
15:239-2»i|
1,3, ii-Hetheno-2U-cyclobata fcd)pentalen-2-one,
1«3-50-0
C10-C110-0
B« «90.68, VP <3X10(B-7) ** Hg at 25 C
, 5i», 6-decachlocooctahydro-
TISSOB
7020
Adipose
7021
Bile
EXPOSOEE BODTE
AKALTTICAL
BETUOD
BDHBBE
OF CASES
BADGE
..
flEJH
GEHEEAL ISFOEBATIOli
Eeview. Heiopecf asion not effective
in removing chlordecone froa blood of
industrially exposed workers, oral
administration of cholestyraaine,
increased fecal excretion of
pesticide and accelerated
disappearance froa body
workers at Kepone manufacturing
Plant, VA
Irritability, memory loss, anxiety.
liver damage and low motile sperm
count
VIBGIKIA; AUDITS; LITER DISEASES;
HEEVOUS SYSTES DISEASES; ADIPOSE
TISSUE; BILE; BLOOD; FECES; LIVES;
BUSCLES; I3DUSTBIA1 BEDICIHE;
CBLORI1IE OEGABIC COMPOUNDS;
PESTICIDES; HEALTH RAZAEDS;
OCCUPATIOHAL BA2A8DS; PESTICIDE
BESIDOES
Deviev. Hemoperf osion not effective
in removing chlordecone frcm blood of
industrially exposed vorkers. Oral
administration of cholestyramine,
increased fecal excretion of
pesticide and accelerated
disappearance from body
Sorters at Kepone manufacturing
plant, TA
Irritability, memory loss, anxiety.
Liver damage and lov motile sperm
count
7IEGIHIA; ADOLTS; LIVES DISEASES;
NEETOOS SISTE9 DISEASES; ADIPOSE
IISSOZ; BIL«; BLOOD; FECZS; LIVED;
BDSCLES; ISDOSTBIAl BEDICIHE;
CELOEIHE ORGASIC COHPODSBS;
PESTICIDES; HEALTH RAZAEDS;
OCCOFtTIOHAI. BAZAEDS; PESTICIDE
RESIDOES
BEFBBESCE
Guzelian, P.S.
1981
Journal of Toxicology
a cd Environmental
Health 8:757-766
Guzelian, P.S.
1981
Journal of Toxicology
and Environmental
Health 8:757-766
u>
(KBIT PAGE)
-------
1,3,«-fletheno-2H-cyclobuta (cd)pentalen-2-one, I.1a,3.3a,t,5.5,5a,5b,6-aecachlorooctahydro-
1H3-50-0
C10-CHO-0
»i »90.68, YP <3I10(E-7) •• Sg at 25 C
(CONTINUED)
TISSUE
7022
Blood
7023
liver
702*
Hnscle
IirOSUBE EOOIE
AHALITICAL
HETBOD
VOREEB
OF CASES
BASSE
BEAU
GENERAL INFORMATION
Review. Hemoperf usion not effective
in renoving chlordecone from blood of
industrially exposed workers. Oral
pesticide and accelerated
disappearance fro* body
plant, VA
Appendicular treaor, opsoclonus.
liver damage and lov motile spern
count
VIRGINIi; SDOLTS; LI»ES DISBSSES;
NEBTOnS STSIEB DISEASES; ADIPOSE
TISSUE; BILE: BLOOD; FECES : LIVES:
BOSCLES; IHDnSTRIll BEDICIDE;
CHLOBIBE OESHHC COnPOONDS;
PESTICICES; BEiLTB HAZARDS;
OCCUPATIONAL HAZARDS; PESTICIDE
RESIDUES
Review. Heaoperf usion not effective
in removing chlordecone frcn blcod of
industrially exposed workers, oral
administration of cholestyraaine,
increased fecal excretion of
pesticide and accelerated
disappearance froa body
Workers at Kepone manufacturing
plant, 7»
Irritability, ne»ory loss, anxiety.
liver danage and low Botile spern
count
VIR6I1IIA; ADULTS; LITER DISEASES;
NERVOUS SYSTEB DISEASES; ADIPOSE
TISSOE: BILE; BLOOD; FECES ; LIVER;
HDSCLES; IKDUSTRIAL DEDICIRB;
CBLORIHE ORGANIC COMPOUNDS:
PESTICIDES; BEALTH HAZARDS;
OCCUPATIONAL HAZARDS; PESTICIDE
RESIDUES
Review. Heioperf usion not effective
in removing chlordecone from blood of
industrially exposed workers. oral
administration of cholestyramine,
increased fecal excretion of
pesticide and accelerated
Workers at Kepone manufacturing
plant, VA
Liver danage and low motile sperm
count
VIRGISIA; ADULTS; 1 IVE8 DISEASES:
NERVOUS SISTEB DISEASES; ADIPOSE
1ISSUE; BILE; BLOOD; FECES; LIVER;
BOSCLES; INDUSTRIAL BEDICINE:
CHLORINE ORGANIC COBPODHDS;
PESTICIDES; HEALTH HAZARDS;
OCCUPATIONAL HAZARDS; PESTICIDE
RESIDUES
REFERENCE
Guzelian, P.s.
1981
Journal of Toxicology
and Environmental
Bealth 8:757-766
Guzelian, P.S.
1981
Journal of Toxicology
and Environmental
Health 8:757-766
Guzelian, P.s.
1981
Journal of Toxicology
and Environmental
Health 8:757-766
u>
M
to
-------
1,3,5-Cycloheptatriene
5H4-25-2
C7-H8
H» 92.15. HP -79.119 C, BP 117 C
TISSUE
7025
Breath
EXPOSOBE BOOTE
AHALTTICAl
METHOD
flC/SS
HDD EEC
OF CASES
28
BINGE
1.9-7.3 ng/1
BEAN
3.8 ng/1
GEHEBAL IHFOBBATIOH
Estimated from graph
Healthy 18-60 yr old nonsmoXers.
Bigid protocol 14 days before and
during study to minimize number and
anount of exogenous constituents.
ADULTS; BBEATH; ALCOHOLS; CHLOBIHE
OBGAHIC COBPOUBDS; CHLOBOBIHZE»ES
BEFEREHCE
Krotoszynski, B.
Gabriel, G.
0' Belli, B.
Claudio, B. P. A.
1977
Journal of
Chroma tographic Science
15:239-244
t«:5,8-Dimethanonaphthalenef 1,2,3,4,10, 10-heiachloro-1 ,4,4a, 5,8,8a-hexahydro-, endo.ezo- (3 CI)
,4:5,8-Di»ethanonaphtbalene. 1,2,3,1,10, 10-hexachloro-1,4,4a,5,8,8a-hexahydro-, (1alpha,4alplia,4abeta,5alpha, 8alpha,8abeta) - (9 CI)
309-00-2
C12-H8-C16
tl« 365.93, HP 104 C, If 6X10(E-6) am Rg at 25 C
TISSOE
7026
Blood
7027
Blood,
fetal
EXPOSOBE BOBTE
AHAHTICAL
BEIHOB
GC
GC
BUHBEB
OP CASES
100
100
BADGE
a) Hot detected- 143. 5 ppb
b) Hot given
d) Sot given
I) tot given
g) Hot given
a) Hot detected-253.3 ppb
b) Hot given
c) Hot given
d) Hot given
e) Hot given
£) Not given
HE AH
a) 21.2 »or- 30.4 ppb
b) 20.6 *0£- 30.7 ppb
d) 17.9 +or- 25.5 ppb
() 23.9 tor- 30.3 ppb
g) 20.8 *or- 26.5 ppb
a) 19.8 »o - 34.3 ppb
b) 18.5 to - 105.0
ppb
c) 22.6 to - 25.1 ppb
d) 34.9 to - 32.8 ppb
e) 17.3 to - 30.7 ppb
g) 22.8 to - 46.7 ppb
GEHEBAL IHFOBSATICH
a) All subjects
t) 60 subjects, ages 18-25 yr
d) 42 subjects, vegetarians
f) »3 subjects, rural
g) 57 subjects, urban
naternal blood, collected 8-12 hr
before parturition
Besidents of Lucknow, India
IHDIA; ADOLTS; AGEJ FETUS; BLOOD;
FLACEHTA; CHLOBIHE OBGAHIC COHPODHDS;
ODD; DDE; DDT; HEIACHLOBOCTCLOHKAHE;
LIHDA8E; PESTICIDES; AGBTCULTUBE;
BIOACCOBULATIOH; DIETS; PBEGHAHCY;
BUBAL ABEAS; OBBAH ABEAS; PESTICIDE
BESIDUES: POPOLATIOB EIPOSDBE
a) All subjects
b) 56 subjects, mother *s age 18-25 yr
c) 34 subjects, mother's age 26-34 yr
d) 36 subjects, vegetarian nothers
e) 54 subjects, non-vegetarian
mothers
q) 48 subjects, urban
Cord blood, collected at delivery
d) and e) , f( and g) significantly
different
IHDIA; ADULTS; AGE; FETUS; BLOOD;
PLACEHTA; CBLOBIHE OBGAHIC CODPOOBDS;
DEC; DDE; DDT; HEXACHLOROCyCLOB fXAKE;
LISDANE; PESTICIDES; AGBICtJLTOKE;
BIOACC
-------
1,«:5,8-DiBethanonaphthalene
1,4: 5,8-Diaethanonaphthalene
309-00-2
C12-B8-C16
HW 365.93, HP 104 C, VP 6X10CE-6) n Hg at 25 C
1,2,3,4,10, 10-hexachloco-1,4,4a,5,8,Sa-hexahydro-, endo.exo- (3 cl)
1,2,3,4,10, 10-hexachloro-1,4,4a,5,8,8a-hexahydro-, (1alpha,4alpha,4abeta,5alpha, Balpha ,8abeta) - (9 CI)
(COJiriH&ED)
TISSUE
7028
Placenta
EXPOSURE ROUTE
ANALYTICAL
IIETHOD
GC
NUKBEE
Of CASES
100
RANGE
a) lot detected-83.3 ppb
b) Hot given
c) Hot given
d) Hot given
e) Hot given
£) Hot given
Hot g ven
MEAH
a) 12.7 to
b) 13.7 to
o) 11.2 to
d) 12.1 to
e) 13.8 to
f) 15.3 to
-.1
-20.4 ppb
- 22.7 ppb
- 15.9 ppb
- 27.5 ppb
-22.5 ppb
- 29.0 ppb
GENERAL INFORMATION
a) All subjects
b) 60 subjects, ages 18-25 yr
c) 40 subjects, ages 26-34 yc
d) 42 subjects, vegetarians
e) 58 subjects, non-vegetarians
f) 43 subjects, rural
Tissue collected at delivery
Residents of Lucknov, India
INDIA; ADULTS: AGE: FETUS; BLOOD:
PLACENTA; CHLORINE OaGAHIC COBPOUNDS;
ODD; DDE; DDT; HEIACHLOEOCTCLOB BEAHE;
LISDAHE; PESTICIDES; AGRICULTURE;
BIOACCUMBLATIOS; DIETS; PREGHAHCY;
RURAL AREAS; UEBAH AEEAS; PESTICIDE
RESIDUES; POPULATION EXPOSURE
REFERENCE
Saxena, n.c.
Siddiqui, M.K.J.
Bhargava, A.K.
Krishna nurti, C.R.
Kutty, D.
1981
48:127-134
1,l»:5,8-Diaethanonaphtbalene, 1,2, 3,4, 10, 10-hexachloro-6,7-epo y- 1,4,4a,5,6,7,8, 8a-octahyaro-, endo,endo- (8 CI)
2,7:3,6-Di«ethanonaphth(2,3-b)oiirene, 3,4,5,6,9,9-hexachloco- a,2,2a,3,6,6a,7,7a-octahydro-, (1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha)- (9 CI)
72-20-8
C12-B8-C16-0
K« 380.9, HP 200 C (deconp), also reported as 245 C (decoip)
TISSUE
7029
Adipose
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC
NUMBER
OF CASES
a) 19
b) 9
c) 9
EiNGE
a) Not detected
b) Not detected
c) Not detected-0.02 ug/g
BEAN j
a) Hot applicable
b) Not applicable
c) Not given
GESEFAL I»FOR»ATIO»
a) Torreon, sexico. Agricultural
region with high pesticide use
b) Hexico City. Pesticide exposure
mainly from foods shipped in fron
other areas
c) Peubla. Industrial and
traditional agricultural region with
low pesticide use (2 samples >0.01
ug/g)
Levels based on extractable lipids.
Nondetectable levels=0.005 ug/g
Residents of Mexico
HEXICC; SUIOPSIES; ADIPOSE TISSUE;
SUSGERY; CHLORINATED HYDROCARBONS;
CHLORINE ORGANIC COBPODSDS; ODD: DDE;
DDT; DIELDRIN: HET.ACHI.OROCYCLOHEXAN E;
LINDAHE; PESTICIDES: PESTICIDE
RESIDUES; POPBliTIOB EXPOSURE; URBAN
AREAS
Albert, L.
Hendez, f.
Cebrian, H.E.
Portales, A.
1980
Archives of
Environmental
35(51:262-269
U>
H-1
Ul
-------
!,»:5,8-Di«ethanonaphthalene, l,2,3,», 10, IO-hexachloro-6,7-epoir-l»««»a. 5,6,7,8,8a-octahydro-, endo.exo- (8 CI)
2,7:3,6-Diiethanonaphth(2, 3-b)oxirene, 3,»,5,6,9.9-heiachloro-1a.2,2a.3,6,6a.7,7a-octahydro-, (laalpha, 2beta,2aalpba,3beta.6beta,6aalpha.7beta.7aalptiat - (9 CI)
6C-57-1
C12-B8-C16-0
B« 380.93, BP 176-177 C. VP 7.783MO(E-7) •• flg at 20 C
TISSUE
7030
Adipose
EIPOSOBE ROUTE
AULRICAL
BETHOD
SC
..
HOBBBB
OF CASES
a) 19
b) 9
c) 9
BUDGE
a) 0.05-0.2» ug/g
b) Sot detected-0.«9 ug/g
c) Hot detected-0.12 ug/g
BEl»
a) 0.06 «oc- 0.07
ug/g
b) 0. 18 *or- 0. 15
ug/g
c) Sot given
GESEBIL INFOK1UTIOS
a) Torreon, Hexicin. Agricultural
region with high pesticide use (11
sanples >0.01 ug/g|
t) nexico City, pesticide exposure
•ainly frov foods shipped in fron
other areas (8 saiples >0. 01 ug/g)
c) Peubla. Industrial and
traditional agricultural region with
low pesticide use (2 sa«ples >0.01
Hondetectable levels=0.005 ug/g
Residents of Metico
HEIICO; AHTOPSIES; ADIPOSE TISSUE;
SOBGEBT; CH1OBISATED HrDBOCABBO»S;
CHLORINE OEGA8IC COBPOOSDS; ODD; DDE;
DDT; DIELDBIH; HEXA CBL050CYCLOBEXANE;
HKDASE; PESTICIDES; PESTICIDE
BESIDUES; POPDLATIOS EIPOSOBE; UEBAB
AREAS
BEFEEESCE
Albert, I.
Bendez, F.
Cebrian, H.E.
Portales, A.
1980
Archives of
Environmental Health
35(51:262-269
2-Bntanol, 3-»ethjl-
598-75-1
C5-H12-0
B« 88.15, BP 128 c
TISSUE
7031
Breath
EIPOSOBE BOOTE
iBiLITICAI
BETHOD
GC/BS
tfOBBEB
OF CASES
28
1ANSE
0.09-1.9 ng/1
asm
..
0.1 ng/1
GENERAL IHFOBBATIOH
Estimated fron graph
Bealthy 18-60 yr olds, nonsaokers.
during study to liniaize nuaber and
aiiount of exogenous constituents.
AEOLTS; BBEATH; 1LCOBO1S; CBXOBIBE
OBGisic CO«POHBDS; CHIOSOBE»ZE»ZS
BEFEBEHCE
KrotoszynsKi, B.
Gabriel, G.
O'Neill, B.
Claudio, B.P.A.
1977
Journal of
chroaatographic Science
15:239- 2»«
2-Butanone, 3,3-diiethyl
75-97-8
C6-B12-0
(l« 100.16, BP -1)9.8 C, BP 106 C at 760 » Hg
7032
Breath
EXPOSURE BOUTE
AKllITICAL
BETBOD
GC/BS
HOHBEB
Of CASES
28
B1HCE
0.2-2.1 ng/1
BEAU
0.65 ng/1
GENEPAL IVFOR NATION
Estimated froi graph
Healthy 18-60 yr olds, nonsnokers.
Bigld protocol 14 days before and
during study to linliize nuiber and
a leant of exogenous constituents.
A DOLTS; BPE4TH; ALCOHOLS; CHLORINE
CEGAHIC COHPOOHDS; CHLOKOBEBZENES
ICrotoszynskir B.
Gabriel, 6.
O'Veill. H.
Claudio, H.P.&.
1977
Journal of
Chroaatocraphic science
15:239-2
-------
2-Octanol
123-96-6
C8-H16-0
B» 130.2, BP -31.6 C. BP 178.5 C, TP 1 •• Hq at 32.8 C
TISSUE
7033
Breath
EXPOSURE ROUTE
ANALYTICAL
KETHOD
GC/BS
»OBBEB
or CASES
23
-
BABGE
0.35-8.5 ng/1
BE ill
1.7 ng/1
GESEKJL IKFOSHATIOS
Estimated from graph
Pigid protocol m flays before and
during study to liniaize number and
ADULTS; BREATH; ALCOHOLS; CBLOB1HE
OEGAHIC COBPOOKDS; CHLOBOBENZENES
BEFEBEHCB
Krotoszynski, B.
Gabriel, a.
Claudio, B.P.A.
1977
Chronatographic Science
15:239-2»<1
2-Pinene (8 CI)
Bicyclo(3.1.1)hept-2-ene, 2.6,6-tri«ethyl- (9 CI)
80-56-8
C10-H16
B« 136.23, BP 155-156 C
TISSOE
7031
Elood
nrine
EIPOSOBE BOD1E
logestioD
nges
IHILITICAL
HETBOD
GCXHS
HOIBEB
OF CASES
1
B1HGE
17 ->1 ug/.l
..
HEiK
Not applicable
GEMERAL I8FOBBRTIOH
•1 pine oil which contained 575 alpha
pinene
Estiaated fron graph
«9 yr old, wt 85 kg, atteapted
suitf ide
Headache, erytheaa of nouth and
larynx, flushed face, ataxia.
spontaneous hyperventilation. 10 hr
after ingestion, inpaired
consciousness, drop in blocd
BLOOD; OPIHE; HETABOLJSH;
flETABOIITES; IBDaSTEIAL CHE1ICALS;
SOLVEKTS
•etabolite (bornyla estate) of alpha
pineoe, after ingesting 400-500 al
pine oil (57y alpha pinene)
B9 yc old, wt 85 kg, attenptea
Headache, erytheia of month and
larynx, flushed face, ataxia.
spontaneous hyperventilation. 10 hr
after ingestion, impaired
consciousness, drop in blood
pressure, leukocytosis
BLCOD; DRINE; METABOLISM;
METABOLITES; IHDOSTEIAL CHEMICALS;
SOLVENTS
BEPEREHCE
Koppel, C.
Tonnesnann, a.
Schrop, T.
Ibe, K.
1981
Archives of Ton coiogy
49: 73-78
Tenczer, J.
Toimesmann, o.
Schirop, T.
Ibe, K.
1981
49:73-78
-------
2,2-Dinethyl-3-hexanone (Ho postings in CHEBLIHE).
C8-H16-0
SH 128.22. BP 115-118 c
TISSUE
7036
Breath
EXEOSOEE ROOTE
A NAUTICAL
METHOD
SC/HS
BOBBER
OP CASES
28
BANGE
0.23-1.8 ng/1
READ
0.65 ng/1
GESEEAL INFORHATION
Estimated froai graph
Healthy 18-60 yr olds, nansiokers.
during study to lininize nuiber and
aiount of exogenous constituents.
ADULTS; BBEATH; ALCOHOLS: CHLOBIHS
ORGAHIC COBPOOHDS; CHLOBOBENZEHES
REFERENCE
Krotoszynski, B,
Gabriel, S.
O'seill, H.
Claudio, H.P.A.
1977
Journal of
Chrooatographic Science
15: 239-2HO
2,2-Di>ethylhexanol (Ho postings in CHEBLINE).
2370-13-0
C6-H18-0
ns 130.26
TISSUE
7037
Breath
EXPOSURE ROUTE
AHALtTICAL
BETNOD
GC/BS
OF CASES
28
BAHGE
0.28-<* ag/1
.
BEAN
1 ng/1
GENERAL IHFOBBATICH
Estinated from graph
Pigid protocol 11 days before and
during study to Bini&ize nunber and
aaount of exogenous constituents.
ACDLTS; BREATH; ALCOHOLS; CHLORIDE
ORGASIC COflPOONDS; CBLOROBEKZEHES
REFEREHCE
Krotoszynski, B.
Gabriel, a.
O'Neill, H.
Claudio, H.P.A.
1977
Journal of
chronatographic Science
15:239-211
1
2,2-Di>ethyloctanol (Ho postings in CHEHLINE).
2370-U-1
C10-H22-O
HS 158.29
U)
H"
oo
TISSOE
7038
Breath
EXPOSDRE BOBT2
ADALITICAL
BETHOD
.
GC/BS
KOBBZ!)
OF CASES
28
-
BADGE
0.35-1.5 ng/1
BEAU
1.3 ng/1
GEUEFAL ISFOBBATIOB
Estimated fron graph
during study to ainifflize nunber and
aaount of exogenous constituents.
ADOLTS; BREATH; ALCOHOLS; CHLOBIHE
ORGANIC COBPOONDS; CHLOROB ENZENES
REFEBE»CE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, fl. P. A.
1977
Journal of
chroiatographic science
15:239-2»«
2.2,3,3-Tetraiethylhexane (Ho postings in CHEflLINE).
13475-81-5
C10-H22
SB 112.32, BP 160.3 C
( TISSOS
7039
Breath
EIEOSDSS H00«
AIALItlCAL
HETBOD
GC/BS
HUB BEE
OF CASES
28
EASGB
0.38-3.8 ng/1
BE AS
1.2 ng/1
-
GENERAL INFOBBATtOH
Estimated froH graph
Healthy 18-60 yr olds, nonsaokers.
Bigid protocol 14 dajrs before and
during study to liniiize nniber and
anount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CRLOBIXE
OBGASIC COBPOOrDS: CHLOBOBEHZERES
.
KEFE HENCE
Krotoszynski, B.
Gabriel, G.
O'Heill, H.
Claudio, B.P.A.
1977
Journal of
chroaatographic Science
15:239-2«1
-------
2,2,5,5-Tetraaethylhexane (Ho postings in CHEBLI8E) .
TISSUE
7040
Breath
EXPOSURE ROUTE
ANALYTICAL
BETHOD
GC/BS
NUHBER
OF CASES
28
BANGE
0.15-1.5 ag/1
HEAH
0.15 ng/I
....
GENJBAL IS FOR NATION
Estimated frOB graph
Healthy 18-60 yr olds, nonsaokecs.
during study to Biniaize nuaber and
amount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS: CHLOBINE
OPGAHIC COflPOUUDS ; CHIOBOBE»ZE»SS
REFERENCE
KrotoszynsJei, B.
Gabriel, G.
O'Neill, H.
claudio, H.P.A.
1977
Journal of
chroaatographic science
15:239-244
2,3,3-Triaethylhexane (No postings in CHENLINE).
C9-H2-0
n« 128.25, BP 137.7 C, TP 10.1 in Bg at 25 C
TISSUE
7041
Breath
EXPOSURE ROUTE
ANALYTICAL
BETHOD
GC/BS
NOBBEE
OF CASES
28
BANGE
0.35-3.3 ag/1
1. 1 ng/1
GEHEEAL IHFOtflATICN
EstiBated fron graph
Healthy 18-60 yr olds, nonsnokers.
Bigid protocol 11 days before and
during study to ninimize number and
anount of erogenous constituents.
ADOLTS; BPEATH; ALCOHOLS; CHLOBINE
OBGANIC COMPOUNDS; CHLOBOBENZENES
K ro tosz yns^ i, 0.
Gabriel, G.
O'Neill, H.
claudio, H.P.A.
1977
Journal of
Chroaatographic Science
15:239-2<*(*
2,3,3,1-Tetraaethylpentane (No postings inCHEflLINE).
16707-38-9
C9-H2-0
g« 128.25, BP -102.123 C, BP 1H1.551 C
to
TISSUE
7002
Breath
EXPOSUEE ROUTE
ANALYTICAL
HETROD
GC/BS
NUII BEE
OF CASES
28
BANGE
0.6-3 ng/1
BEAN
1.4 ng/1
GENEBAL ISFOBBATIOH
Estimated froa graph
Healthy 18-60 yr olds, nonsnokers.
Bigid protocol lit days before and
during study to nininize nuaber and
amount of exogenous constituents.
8DOLTS; BREATH; ALCOHOLS; CHLOEINE
OBGABIC COHEOUNDS; CHLOEOBINZENES
REFERENCE
Krotoszynski, 3.
Gabriel, G.
O'Seill, H.
Claudio, It. p. A.
1977
Journal of
Chromatographic science
15:239-2411
3-Heptanone, 2-aethyl-
13019-20-0
C8-H16-0
B« 128.24
TISSUE
7043
Breath
BIPOSOBE SOOTE
ANALYTICAL
BETHOD
GC/BS
HU8BZB
OF CASES
29
BADGE
0.2-1.6 ng/1
0.55 ng/1
GENEBAL IHFOBBATIOH
Estimated froa graph
Healthy 18-60 yr olds, nonsaokers.
Eigid protocol lit days before and
during study to aininize nuaber and
amount of exogenous constituents.
ACDLTS; BREA.TH; ALCOHOLS; CHLORINE
OEGAHIC COHPODHDS; CHLOROBEBZEHES
i
Krotoszynski, B.
Gabriel, G.
0'Belli, H.
Claudio, n.p.A.
1977
Journal of
Chronatographic Science
15:239-2111
-------
3-Heptanone, 5-aethyl-
501-85-5
C8-H16-0
en 123.22, BP 160.5 C, VP 2.0 •• Hg at 25 C
TISSUE
70411
Breath
EXPOSURE EOOTE
ANALYTICAL
BETHOD
GC/BS
BOBBER
OF C1SES
28
BAHGE
0.08-0.35 ng/1
BEAN
0.18 nq/1
GESEBAL INFOEHATION
Estiaated fron graph
Healthy 18-60 yr olds, nonsaokers.
during study to niniaize nuuber and
attount of exogenous constituents.
ACOLTS; BBEATH; ALCOHOLS; CHLORINE
OEGA»IC COBPOOHDS; CHLOROBINZEHES
EEFEBEHCE
Gabriel, S.
O'Neill, B.
Claudio, B.P.A.
1977
Chcoaatographic Science
15:239-2HU
3-Hexanone, 2,1-dijethyl-
18601-70-8
C8-H16-0
BW 128.21, BF 1X5 C
7015
Breath
EIPOSUfiE ROOTE
ANALYTICAL
BETHOD
H On BEE
OF CJSES
28
0.035-0.52 ng/1
0.13 ng/1
GEHEBAL HIFOEIHTIOK
Estioated from graph
Healthy 18-60 yr olds, nonsiokers.
Rigid protocol 14 days before and
during stud; to liniiize nuiber and
avotlnt of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLOEDIE
ORGANIC COBPOOBDS; CHLOEOBENZE8ES
Krotoszynski, B.
Gabriel. G.
O'Neill, B.
Claudio, B.P.A.
1977
Journal of
Chroaatographic Science
15:239-200
CO
K)
o
3-Hexen-1-ol, (E)-
928-97-2
C6-H12-0
US 100.16, BP 156-157 C
TISSUE
70 »6
Breath
EKfOSOBE EOOTE
_
AHALTTICAL
BETBOD
_
GC/BS
_ ... -
MDBBEB
or CASES
28
BINGE
0.5-6 ng/1
BEAN
1.8 nq/1
GENERAL INFORHATION
Estimated froi graph
Healthy 18-60 yr olds, nonsiokers.
Pigid protocol It days before and
daring study to •iniaize number and
aaount of exogenous constituents.
ADOLTS; BEEATH; ALCOHOLS; CHLOEIKE
ORGANIC COHPOUNDS; CHLOBOBENZEB ES
EEFESENCE
KrotoszYoski, B.
Gabriel. G.
O'Neill, H.
Claudio, B.P.A.
1977
Journal of
chroaatographic Science
15:239-200
-------
3-Pentanone, 2-methyl-
565-69-5
C6-H12-0
US 100.16. BP 11».5-115 C
TISSOE
70H7
Breath
EXPOSOBE BOOTE
ANALYTICAL
HETHOD
GC/BS
NOBBEB
OF CASES
28
RANGE
0.09-0.55 ng/1
BE AH
0.23 ng/1
GENEBAL INFOBBATION
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
Bigid protocol 14 days before and
during study to minimize number and
amount of exogenous constituents.
ADULTS; BREATH; ALCOHOLS; CHLORINE
OBGANIC COBPOOSDS: CHLOBOBENZEN BS
BEFEBEHCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, B. P. A.
1977
Journal of
Chromatographic science
I5:239-2«K
3,3-Diethylpentane (No postings in CHEBLIHE) .
TISSOE
7018
Breath
_
EXPOSURE BOOTE
ANALYTICAL
BETHOD
GC/BS
HOBEEE
OF CASES
28
RANGE
0.09-0.9 ng/1
BEAN
0.3 ng/1
GENERAL INFOBBATION
Estimated from graph
Piqid protocol I1* days before and
during study to minimize number and
amount of exogenous constituents.
ACDLTS; BBEATH; ALCOHOLS; CBLOBINE
OBGASIC COHPOOSDS; CHLOBOB EHZENES
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, B.P. A.
1977
Journal of
Chromatographic Science
15:239-21111
3,4-Dimethylheptane (No postings in CHEBLIME).
922-28-1
C9-B2-0
B» 128.25, BP 1140.6 C
70*9
Breath
F.XPOSOBE BOOTE
ANALYITCAL
BETHOD
.
GC/BS
-
NDHBEB
OF CASES
28
BANGE
0.55-5 ng/1
BEAU
1.5 ng/1
GENEBAL INFOBBATI08
Estimated from graph
Healthy 18-60 yr olds, nonsmokers.
aiount of exogenous constituents.
ADULTS; BEEJTH! ALCOHOLS; CHLORINE
OEGANIC COBPOONDS; CHLOBOBENZENES
B
Kcotosz y
Gabriel,
O'Neill,
Claudio,
1977
Journal
Chromato
15:239-2
4-EOnenal, (E)-
2277-16-9
C9-H16-0
TISSOE
7050
Breath
1
EIPOSOBE EOOTE
ANALYTICAL
BETHOD
GC/BS
.
HOHEEB
OF CASES
28
RANGE
0.65-9 ng/1
KEAN
2.3 ng/1
GENERAL INFORBATICN
Estimated fcoii graph
Healthy 18-60 yr olds, nonsmokers.
Rigid protocol 1<* days before and
during study to minimize number and
ADULTS; EBEATH; ALCOHOLS; CHLOBIRE
ORGANIC COHPOONDS; CHLOBOBINZENES
REFERENCE
Krotoszynski, B.
Gabriel, G.
O'Neill, H.
Claudio, B. P. ».
1977
Chromatographic Science
15:239-2iia
-------
I.H'-Bipyridinium, 1,1 '-dimethyl-
1685-11-7
C12-H1H-N2
(IB 166. HP 300 C (decoipl
7051
Bile
7052
Blood,
plasna
7053
Brain
EXFOSUBE ROUTE
Ingestion
Ingestion
Ingestion
»«»LYIICAL
BEIHOD
Coloriietr;
Colorimetry
Colorimeter
NUHBER
OF CASES
0.10-3.0 ppl
a) Hot given
b| >0.25-0.041 ppm
0.09-0.3 ppm
Not given
a) 1.5 ppm
b) Mot given
Hot given
GENERAL IHFOBHATIOH
Suicide victims
28 and 57 yr old Caucasians,
California
Nausea, muscle cramps, anuria,
hypotension, shock
lungs heavy and airless vith
congestion, edema* and fibrosis.
Eronchi and trachea contained thick
bloody liquid. Liver enlarged vith
greenish or yellow discoloration and
centrilobular necroses. Acute
tubular necrosis of kidney. Cortical
necrosis and focal hemorrhages of
adrenal.
CALIFOFNIA; ADULTS; AUTOPSIES;
SUICIDE; BLOOD PLASBA; PLEURAL FLUID;
ORISE; HEASOREHEHT BETHODS;
PESTICIDES
a) 30 hr after 2.5 cups of 21*
solution. Postmortem sample 0.5 ppm
b) 20 hr and 13 days after 0.5 cups
of 20* solution
Suicides
28 yr old Caucasian and 18 yr old
Oriental, California
Hausea, nuscle cramps, anuria,
hypotension, shock
Xutigs heavy ana airless with
congestion, edema, and fibrosis.
Bronchi and trachea contained thick
bloody liquid. Liver enlarged with
greenish or yellow discoloration and
centrilobular necroses. Acute
tubular necrosis of kidney. Cortical
necrosis and focal hemorrhages of
adrenal.
CALIFORNIA; ADULTS; AUTOPSIES;
SUICIDE; BLOOD PLASBA; PLEURAL FLUID;
DRIHE; HEASOREnEHT flETBODS;
PESTICIDES
(BEXT PAGE)
Suicide victims
18 yr old oriental and 28 and 57 yr
old Caucasians, California
Hausea, muscle cramps, anuria,
hypotension, shock
Lungs heavy and airless vith
congestion, edema, and fibrosis*
Bronchi and trachea contained thick
bloody liquid. Liver enlarged with
greenish or. yellow discoloration aod
centrilobular necroses. Acute
tubular necrosis of kidney. Cortical
necrosis and focal hemorrhages of
adrenal.
CALIFORBIA; ADULTS; AUTOPSIES;
SOICIDE; BLOOD F1ASH1; PLEURAL FLUID;
OEINE; KEASDBEHEHT BET BODS;
J PESTICIDES
I
Russell, L. ».
Stone, B.E.
Booney, p.A.
1981
Clinical Toxicology
18(8):915-928
Russell, L.I.
Stoue, B.E.
Booney, P.A.
1981
Clinical Toiieology
18(8)1915-928
U)
Russell, L.A.
Stoae, B.E.
Booney, P.A.
1981
Clinical Toxicology
18(8):915-928
-------
-------
(.H'-Bipyridiniui. 1,1 '-di.ethyl-
H685-1H-7
C12-B11-82
HW 186, HP 300 C (decoip)
(COHTIinJED)
TISSUE
7057
Luag
Pleural
fluid
7059
Spleen
EIPOSUBE ROOTE
Ingestion
ANALITIC4L
HETHOD
Coloriietr;
NOB BEE
OF CISES
3
1
BADGE
0.05-3.0 ppl
Hot applicable
Not given
0.049 ppm
(NEXT PAGE)
SENEGAL INFORMATION
Suicide victims
16 yr old Oriental, and 28 and 57 yr
old Caucasians, California
Nausea, nuscle cramps, anuria,
hypotension, shock.
lungs heavy and airless with
congestion, edema, and fibrosis.
Bronchi and trachea contained thick
bloody liquid. Liver enlarged with
greenish or yellow discoloration and
cectrilobular necroses. Acute
tubular necrosis of kidney. Cortical
necrosis and focal hemorrhages of
adrenal.
CALIFORNIA; ADULTS; AUTOPSIES;
SOICIDE; BLOOD PLASMA; PLEUBAL FLUID;
URINE; MEASUREMENT METHODS;
PESTICIDES
3 days aftec 0.5 cups of 20%
solution, suicide victim
18 yr old Oriental, California
Nausea, muscle cramps, anuria,
hypotension, shock
Lungs heavy and airless with
congestion, edema, and fibrosis.
Eronchi and trachea contained thick.
bloody liquid. Liver enlarged with
greenish or yellow discoloration and
centrilobular necroses. Acute
tubular necrosis of kidney. Cortical
necrosis and focal hemorrhages of
adrenal.
CALIFORNIA; ADDLTS; AUTOPSIES;
SUICIDE; BLCOD PLASMA; PLEURAL FLOID;
DRIHB; MEASUREMENT METHODS;
PESTICIDES
Suicide victim
28 yr old, California
Nausea, muscle cramps, anuria,
hypotension, shock
Lungs heavy and airless with
congestion, edema, and fibrosis.
Bronchi and trachea contained thick
bloody liquid. Liver enlarged with
greenish or yellow discoloration and
centrilobular necroses. Acute
tubular necrosis of kidney, cortical
necrosis and focal hemorrhages of
adrenal.
CALIFORNIA; ADULTS; AUTOPSIES;
SUICIDE; BLOOD PLASMA; PLEURAL FLUID;
DEINE; MEASOBBHEBT METHODS;
PESTICIDES |
I.
Russell, L.A.
Stone, B.E.
Booney, p.i.
1981
Clinical Toxicology
18 (8) :9 15-928
Russell* L,A.
Stone, B.E.
Booney, p*A.
1981
Clinical Toxicology
18<8):915-928
Russell, L.A.
Stone, B.E.
Booney, P.A.
1981
Clinical Toxicology
18[8):915-928
-------
»,
Ln
TISSUE
7061
Blood,
EXPOSDEE EODTE
Injection
Ingestion
AHALTTICAL
BETHOD
BP1C
NUnBEE
OP C1SES
a) «
b) 7
EANGE
a) 3.1-1.3 ug/nl
b) 12-30 ag/il
BEAN
a) Hot gxven
b) Not given
GENEBAL IHFORHATION
a) «5 Bin and 2 hr after 1.5 mg/kg IV
bolus and sustained infusion of *>
ug/kg/min. Final neasurement 1.7
ug/nl at 10 hr
b) 0.5 and 1.5 hr after 3 ng/kq oral.
Final Bieasureatent 1.5 ug/nil at 5 hr
Kange of means, estimated froa graph
Patients with congestive heart
failure
HEAET DISEASES; BLOOD PLASMA; DRUG
THEPAPY; DPTJGS
_
BEFEEBHCE
Edelson* 0.
LeJentel, T.H.
Alousi, A. A.
Biddlecome, C.
Haskin, C,s,
Sonnenblick , E.H.
1981
Clinical Phaoacology
and Therapeutics
29(6):723-728
-------
Acetamide, N-anidino-2-(2.6-dichlorphenyl)- (8 CD
Benzeneacetamide, N-(aminoiminomethyl)-2,€-dichloro- (9 CI)
29110-H7-2
C9-H9-C12-S3-0
BB 246.11
TISSUE
7062
Blood,
plasma
7063
Blood,
serun
.
706«
Orine
EXPOSURE 500TE
Injection
Ingestion
Injection
Injection
AMLY.TICAL
HETHOD
sc/ns
GC/BS
GC-EC
-
SDHBEB
OP OSES
18
a) 6
b) 6
c) 6
RMiGE
a) 3.5-9.7 ng/al
b) 0.8-1.9 ng/ml
a) 23-2 ng/il
b) 12-2 ng/il
a) Hot given
b| Hot given
c) Not given
GENERAL INFORBATICN
a) Not given
D) Not given
a) Mot given
b) Not given
a) 57 tor- 32.0)1
(1.71 g)
b) 11.0 +or- 9.0*
(0.12 g)
c) 7.5 »or- 2.4X
(0.23 g)
a) Day 5 of therapy
b) US hr after last dose
Dose 3 ag/day
Levels not significantly correlated
with degree of renal impairment
21-65 yr old hypertensive patients
with glomerular filtration cate
between 3.8-113 »l/»in.
GEPHA»y; HYPERTENSION; KIDNEY
DISEASES; BLOOD PLISS1; UBISE;
JSTIHY.PERTEBSIVE AGENTS; DBUGS;
GIEB1HY
a) Hypertensive patients with normal
renal function
b) urenic patients
Initial measurement and 48 hr after 3
•9, IV
Pange of means estimated fron graph
GERH8BT; HIPEHTEHSION; KIDNEY
DISEASES; BLOOD PUSBA; DRINE;
ANTIBYPERTENSIVE AGENTS; DRUGS
a) Normal renal function
b) Moderate renal impairment
c) Oremic patients
Cumulative excretion ap to 48 hr
after 3 mg, IV
21-65 yr old hypertensive patients
GERBANY; HYPERTENSION; KIDNEY
DISEASES; BLOOD PLASBA; URINE;
ASTIHYPERTEBSIVE ASENTS; DROSS;
GERBANY
Kirch, H.
Kohlec, H.
Braun, H.
Gizycfci, C.v.
1980
Clinical
Pharmacofcinetics
5:176-483
Kirch, B.
Kohler, H.
Braun, W.
Gizycki, C.v.
I960
Clinical
Pharmacokinetics
5:476-483
Kirch, ».
Kohler, H.
Bcaun, H.
Gizycki, C.v.
1980
Clinical
Phacmacokinetics
5:476-483
-------
Acetaii.de, 2-(p- (2-hydroxy-3- (isopropylamino) propoxy) phenyl) - (8 CI)
Benzeenacetamide, »-(2-hydroiy-3-((l-«ethylethyl| a«ino) propoxy) - (9 CI)
29122-68-7
C14-H22-N2-03
HS 266.31, DP 146-1118 C
TISSUE
7065
Blood,
plasma
7066
Blood,
plasma
7067
Urine
EXPOSURE R001E
Ingestion
Ingestion
Infection
Ingestion
&HALITICAL
METHOD
Fluoroietry
GC
?luorometry
1 HOHBEB
OF OSES
6
a) 5
b) 5
c) 5
d) 5
6
SINGE
a) Hot given
b) Hot given
c) Hot given
d) Hot given
e) Not given
f) Hot given
g) Hot given
h) Hot given
a) 0.5-0.03 ug/Bl
b) 0.6-0.2 ug/ml
c) 0.8-0.08 ug/ml
d) 1. 1-0.05 ug/Bl
a) 3.9-5.0 ig
b) Hot applicable
c) Hot given
d) Hot given
e) Hot given
f) Hot given
g) Hot given
fa) Hot given
i) Hot given
j) Sot given
BEAN
a) 511 or- 59 ng/ml
b) 250 or- 13 ng/ml
c) 163 o- 56 ng/»l
d) 463 or- 56 ng/nl
e) 410 or- 28 ng/ml
f) 325 or- 27 ng/ml
g) 360 or- 58 ng/ml
h) 511 or- 30 ng/ml
S.E.
a) Not given
b) Not given
c) Not given
d) Hot given
a) 4.4 +or- 0.2 mg
b) 14.3 g
c) 40 o - 6 mg
d) 31 0 - 3 ng
e) 48 o - 8 mg
:) 48 o - 3 mg
g) 47 o - 5 mg
h) 36 o - 3 mg
i) 31 o - 6 mg
]) 36 o - 6 mg
S-E .
GENERAL INFORMATION
a) Single dose 100 log
t) Single dose 100 mg plus 500 mg Ca
c) Single dose 100 mg plus 5.6 g
Al(OH) 3
d) Single dose 100 mg plus 40 mg
f urosemide
e) Dose as in a) for 6 days
f) Dose as in b) for 6 days
g) Dose as in c) for 6 days
h) Dose as in d) for 6 days
Peak level 2.5-4.0 hr after last dose
A1(OH)3 decreased mean peak 20*
Ca decreased mean peak 51% and
increased elimination half-life
Healthy 25-32 yr olds
ADULTS; BLOOD PLASHA; URINE;
ANTIARBHYTHIIC AGEBTS;
ANTIHY.PEBTENSIVE AGENTS: DIURETICS;
DRUG THEHAPY; DBOGS ; AMBI HUB;
CA1CIUH; BLOOD PBESSURE
a) 1 and 33 hr after 25 mg
b) 2 and 48 hr after 50 mg . Initial
measurement 0.03 ug/ml at 1 hr
c) 1 and 48 hr after 100 mg
d) 2 and 48 hr after 200 mg. Initial
measurement 0.09 ug/ml at 1 hr
Range of means, estimated from graph
Healthy 18-33 yr olds
Duration of cardiac beta blocking
activity determined by elimination
half life and dose.
ADULTS; BLOOD PLAStlA; DRUGS;
C01PJRATIVE EVALOAriOBS
a) After 5 mg 11, 5 subjects
b) After 20 mg IV, 1 subject
c) After single oral dose, 100 mg, 6
subjects
d) After single oral dose, 100 mg.
plus 500 mg Ca, 6 subjects
e) After single oral dose, 100 ig.
plus 5.6 g A1(OH)3 6 subjects
f) After single oral dose, 100 mg.
plus 40 mg furosemide, fi subjects
subjects
h) Dose as in d) for 6 days, 6
subjects
i) Dose as in e) for 6 iays, ft
subjects
1) Dose as in f) for 6 days, f
subjects
48 hr total after last dose
Kinetics changed with addition of Ca
Healthy 25-32 yr olds
ADOLTS; BLOOD PLASMA; UBINE;
AKTIABPPYTHBIC AGENTS;
ANTIPYPEBTEHSIVf! ASENTS; DIURETICS;
DRDG THERAPY; DRDGS ; AHJHIBUH;
CA1CIU1; ELOCD PRESSURE
REFERENCE
Kirch, w.
Schafer-Korting, H.
Axthelm, T.
Kohler, H.
Hutschler, E.
1981
Clinical Pharmacology
and Therapeutics
30 (4): 429-435
Harron, D.H.G
Balnave, K.
Kinney, C.D.
Wilson, F.
Russell, C.J.
Shanks, E.G.
1981
and Therapeutics
29(3):295-302
Kirch, «.
Schafer-Korting, 1.
Axthelm, T.
Kohler, H.
nutschler, E.
1981
Clinical Pharmacology
and Therapeutics
30(4) :H29-435
-------
Acetamide, 2,2-dichloro-N- (beta-hydroiy-alpha- (hydroiymethyl) -p-nitrophenethyl) -, D-threo-(-)-, (8 CI)
Acetamide, 2,2-dichloro-N- (2-hydroxy- 1- (hydroiymethyl) -2- (4-nltrophenyl)ethyl) -, (E-(R*,B»))- (9 CI)
56-75-7
C11-H12-C12-S2-05
HB 323.14, HP 150.5-151.5 C
Tissoy
7068
Blood,
serum
Blood,
seruB
1070
Drine
EIPOSOBI BOOTS
.
Injection
Infection
A«iLITlc»L
HETHOD
CC
cc
HDHBEB
OF CASES
12
b| 2
12
BINGE
3) 3. 94-76. 8» ag/ml
b) 0.11-3.9 ug/ml
o| 9.3-66.67 ug/ml
d) 3.66-13.7 ug/ml
b) 6.7-52 ug/»l
s| 7.56K-42.56S
b) 3.05X-25.8X
a) 27.91 »ot- 19.13
ug/«l
b) 1.59 *or- d. 93
ug/»l
c) 29.64 »or- 16.17
ug/Bl
d) 13.82 tor- 11.61
ug/Bl
GEKEEJL IKFOEIIATICN
a) Hot applicable
b) Hot applicable
a) Hot qirea
b) Not given
aj Peak levels chlocaiphenicol
succinate (prodcug)
b> 6 hr, chlorajDphenicol succinate
c) Peak levels chloraophenicol
(metabolite)
d) Trough levels chloraiphenicol
Steady states
After chloraaphenisol succinate, 100
•g/kg/'lay, in i» equal doses, 0.5-1 ht
IV for at least 2 days before
steady-state neasurevents
Data show incomplete hydrolysis of
chlorairphenicol succinate to
chlora»phenicol
2.5 .0-20 yr old patients
CHILDREN: I9FASTS; CENTEAL NERVOOS
SySTEM DISEASES: BLOOD SEEOB; OEISE;
ANTIBIOTICS: DRUG THEEAPT; DRUGS;
HETABOLISH; 8ETABOI.IIES
a) 2 and 6 hr after 25 nq/kq IV.
Initial neasureaent 35 ug/al
b) Initial Measurement and 2 hr after
25 «q/kg IV. Level at 6 hr 9.5
ug/il. Phenobeiibital also qiven
a) Significantly higher than b) at 1
hr
Range of neans, estimated from graph
3-18 so old infants, treated for
meningitis, brain abcess, or
pneumonia
EESPIPATOBT DISEASES; INFAHTS;
CENTRAL NESVOOS SISIEB DISEASES;
BLOOD SERUfl; ANTIBIOTICS: DSOG
INTERACTION; DEOG TBERiPT; DEOG5
a) Unchanged chloramphenicol
succinate (prodrug)
b) CVilorampbenicol (metabolite)
* cf dose recovered during 6 hr
interval
After chloramphenicol soccinate, 100
mg/kg/day, in 4 equal doses, 0.5-1 hr
IV for at least 2 days before
measurement
Data demonstrated incomplete
hydrolysis of chloramphenicol
succinate to chloramphenicol
2.5 mo-20 yr old patients
CHILDREN: INFANTS: CENTRAL NERVOOS
STSTE9 DISEASES; BLOOD SBROfl; OBINE;
ANTIBIOTICS: DSOG THERAPI; DRUGS:
nETABOLISBj BET ABOMTES
REFERENCE
Nahata, n.c.
Povell, D.A.
1981
Clinical Pharmacology
and Therapeutics
30(31:368-372
Burckart, G.J.
Barrett, I.r.
Straughn, A.B.
Ternullo, S.B.
1982
Journal of Clinical
Pharmacology 22:19-52
UJ
U)
O
Nahata, n.c.
Powell, D.A.
1981
Clinical Pharmacology
and Therapeutics
30(3):368-372
-------
Acetanilide, 4'-hvdroxy- (8 CI)
tcetamide, B-(4-hydroxyphenyl)- (9 CI)
103-90-2
C8-H9-B-02
B« 151.16, 8P 169-170.5 C
TISSUE
7071
Blood,
plasma
7072
Blood,
plasma
7073
Blood,
plasma
7074
Blood,
serum
EIPOSOBE BOOTE
Ingestion
Inqestion
AHALTTICAL
BETHOD
HPIC
GC
HPIC
8PLC
NOR BEE
OF CASES
1
1
a) 15
b) 17
c) 12
d) 14
e( 3
£( 7
9) 26
h) 52
1
B1HGE
270-10 ug/il
a) Hat applicable
b) Hat applicable
c) Hot applicable
a) Hat give
b) Hat giv
c) Hot giv
d) Hot giv
e) Hat giv
f) Hot giv
g) Hot give
h) Hat give
Hat applicable
(HEIT
HEAH
Hot given
a) 1,150 mg/1
b) 810 mg/1
c) 47 mg/1
a) 136 tor- 46 ug/Bil
b) 310 tor- 161 uq/ml
c) 2310 *or- 910
ug/ml
d) 2626 «or- 618
ug/ml
e) 1126 *or- 367
ug/ml
f) 3255 »or- 1446
ug/ml
q) 30.2 »or- 3.5
ug/ml
h) 27 »or- 2. 1 ug/ml
21 mg/1
PAGE)
GEHEBIL INPOBnATICK
7.S and 30.5 hr after overdose of
30-UO 750-»g capsules
Fstiaated froa graph
26 vr old vho attempted suicide
tDDLIS; CA5E HISTORIES; BLCOD PL1SH1;
DEIIE; *S1I.GESICS; DBDG 1BOSE; DBDGS
a) It adiission
t) 17 hr later, at beginning of
charcoal heaoperfusion
c) after 10 hr heBOperfasion
Dose unknown
43 yr old
Unconscious, hypotensive, recurrent
•yoclonns, vertical nystagmus,
•etabolic acidosis, lov plasva
bicarbonate, cerebral infarcts,
intracerebral heiatoaa
0BITED KIHSDOH; iDOLESCEHTS; tDOLTS;
CASE HISTOBIES; BLOOD PUSS A; DBRG
ABUSE; DBIIGS; HTPHOTICS; BUSCLE
BELAXAHTS; THEOPBYLIISES
a) Acetylcysteine therapy vithin 10
hr of overdose, 12-16 yr olds
t) Same as a), 17-21 yr olds
c) Acetylcysteine Therapy 10-2H hr
postingestion, 12-16 yr olds
d) Same as c), 17-21 yr olds
e) Acetylcysteine therapy 2tt* hr
postingestion, 12-16 yr olds
f) Same as e), 17-21 yr olds
g) Ingestion of nontoxic dose, 12-16
yr olds
h) As in g) 17-21 JT olds
Knovn or suspected ingestien of 7.5 g
or Bore.
Crug overdose victims
Ho relationship to subsequent Eeye's
syndrome could be demonstrated
ADOLESCENTS: CHILDREN; BLOOD PLASMA;
ANALGESICS; DROG ABUSE; DRDGS
1 day after about 20 500 mg tablets
43 yr old alcoholic. The Netherlands
Drowsiness, thrombocytopenia and
diffuse abdominal pain
CASE HISTOBIES; CHILDBEH; BLOOD
SEB0B; AHALGESICS; AHTI-IHPLAHBATOBr
AGEKTS; DR0GS; NETHER!A»DS; ADULTS
BEFEBEHCE
nelethil, s.
Poklis, A.
Schwartz, H.s.
1981
Veterinary and Human
Toxicology
23(6) :421-»23
Baper, s.
Crome, P.
Vale, A.
Helliwell, H.
Widdop, B.
1982
Archives of Toxicology
49:303-310
Bumack, B.H.
Peterson, B.G.
1978
pediatrics
62(suppl.):898-903
Oges, D.B.A.
Bloemhof, K.
Christensen, E.K.J.
1981
Pharnaceutisch Ueekblad
Scientific Edition
3:205-211
-------
Jcetanili.de, U'-hyStoxy- (8 CI)
Acetaiide, H-(4-hydroxyphenyl)- (9 CI)
1C3-90-2
C8-H9-H-02
NH 151.16. HP 169-170.5 C
(CONTINUED)
TISSUE
7075
Blood,
serum
7076
Urine
EXPOSURE ROUTE
Ingestion
Ingestion
ANALYTICAL
niTHOD
color! metry
N on BEE
OP CASES
1
1
BADGE
a) Hot applicable
b) Hot applicable
294-370 mg/hr
MEAN
a| 94 119/1!
b) 26 ug/nl
331 mg/hi
GENERAL INFOBHATION
a) 24 he after estimated 35 325-mg
tablets
b) 48 hr
3 yr old, vt 14.2 kg. Kith
acetaminophen poisoning, NC
Headache, nausea, vomiting, anorexia.
paleness, lethargy, somnolence.
followed by high levels of hepatic
enzymes and bilirubin.
Increased prothrombin tine due to
BOPTH CABOLIHA; CHILDBEN; BLOOD
SERUH; ANALGESICS; ANTIPYEETICS ;
DPUGS
_
10-22.5 hr after overdose of 30-40
750 mg capsules
26 yr old who attempted suicide
AUDITS; CASE HISTORIES; BLOOD PLASnA;
OBIHE; ANALGESICS; DBDG ABUSE; DRUGS
REFERENCE
Arena, J.B.
Rourk, H.H., Jr.
sibrack, C.D.
1978
Pediatrics 61(1):68-72
Heletbll, S.
Poklis, A.
Schwartz, H.S.
1981
Veterinary and Human
Toxicology
23(6) :i421-423
Acetone (8 CI)
2-Propanone (9 CI)
67-61-1
C3-H6-0
B» 58.08, «P -9U.6 C,
BP 56.»8 C, ?P UOO •> Bg at 39.5 C
UJ
U>
K)
TISSUE
7077
Blood,
serun
EXPOSDRE ROUTE
Ingestion
ANALYTICAL
BKTHOD
SC
KDflDER
Of CASKS
1
BADGE
Hat applicable
0.18 g/1
GSSERAL WFORHATIO"
Unknown dose of ethanol-isopropanol
45 yr old
Coma, respiratory distress
BLOOD SEEOB; DRUG ABUSE; DBOGS;
AICOHOLS
rasiliades, J.
Pollock, J.
Robinson, C.A.
1978
Clinical Chemistry
2U(2):383-385
-------
Aluiinun
7429-90-5
Al
AtB 26.98154, HP 660 C. BP 2327 C, VP 1 n Hg at 1540 C
TISSUE
7078
Blood,
plasna
EIPOSOBE BOOTE
ANALYTICAL
BETHOD
A»S
NOBBEB
OF CiSES
a) 20
b) 20
BINGE
a) Not given
b) Not given
BEAN
a) 1.59 »ot- 1.26
umol/1
b) 4.39 tor- 3.69
umol/1
GENEBAL INFOEIHTION
a) Limited care dialysis patients.
Daily oral »1(OH3) dose ?. 13 tor- 4.3
g. »1 dialvsate 0.037 umol/1
b) Home dialysis patients. Daily
oral »1(OB3) dose 5.4 *or- 6.7 g. Al
dialysate 0.37 *or- 0. »9 uiol/1
b) significantly higher than a)
Clinically stable patients on
intenittent dialysis >9 months.
HEBODISLYSIS; KIDNEY DISEASES;
CALCIDH; HETALS; PHOSPHOBOS; BLOOD;
BIOOD PLASMA; ALOBINOII
BEFEBENCE
Zuakley, H.
Bertrav* H.p.
Graefe, 0.
Langer, K.
1980
Proceedings, Diuversity
of Missouri Annual
Conference on Trace
Substances in
Environmental Health
14:299-303
(NEXT PAGE)
-------
AluainuB
7(29-90-5
II
At« 26.98154, HP 660 C, BP 2327 C, vp t it Kg at 1540 C
7079
Blood,
plasaa
7080
Cartilage
EXPOSURE ROUTE
Ingestion
Ingestion
ANALYTICAL
SETHOD
Polarograpby
(COHTIHUED)
NUHBEB
OP CASES
5
0 1
>) *
BINGE
a) 10-27 ug/1
b) Hat
c) Hat
d) Hat
e( Hot
f) Hat
g) Hot
h| Hot
i| Nat
1) Hat
k) Hat
1) Hot
B) Hot
n) Hat
a) Hat
P) Hot
q) Hot
a) lot
b) Hat
given
given
given
given
given
give
give
give
give
give
give
give
give
give
give
give
given
given
a) 19 ug/1
b) 42 ug/1
c) 117 ug/1
a) 77 ag/1
36 ag/1
16 ug/1
29 ug/1
22 ug/1
39 ug/1
101 ug/1
125 ug/1
18 ug/1
91 ug/1
71 ug/1
43 ug/1
88 ug/1
82 ug/1
a) 22 ug/g
b) 8.3 »or- 2.0 ug/g
net >t
S.E.
GENERAL INFOBBATIOH
a) 71 yr old with osteoporosis, Al
intake 3.28 ag/day, Al balance -0.7
ng/day, periods 1-5
k) Patient a), intake S.22 ng/day,
balance 0.3 aq/day, periods 6-10
C) Patient a), intake 1082 ag/day
(diet plus 90 ml/day Haalox), balance
255 ng/day, periods 11-14
d) Patient a), intake 5.09 ig/day,
balance -0.2 Bg/day, periods 15-18
e) 69 yr old, intake 14.93 ag/day,
balance -24.7 ag/day, periods 1-1
J) Patient e) , intake 1910 ag/day
(diet plus 90 Bl/day Amphogel) , Al
balance 247 ag/day, periods 5-7
g) 12 yr old with osteoporosis,
intake 1637 ag/day (diet plus 120
Hi/day nylanta), balance 250 ag/day,
periods 10-11
h) Patient g) , intake 3.31* ag/day,
balance -8.8 ag/day, periods 15-19
i) 54 yr old vith osteoporosis and
cerebellar degeneration, intake 5.15
ag/day, Al balance -3.5 ag/day,
periods 1-5
1) Patient i) , intake 1081 ag/day
(diet plus 90 al/aay naalox), balance
89 ag/day, periods 6-10
k) Patient i), intake 5.28 ag/day,
balance -6.0 «g/day, periods 11-1S
1) 50 yr old, history of osteoporosis
and alcoholism, intake 3.67 >g/day,
balance -3.9 ag/day, periods 1-5
•) Patient 1), intake 1080 ag/day
(diet plus 90 nl/day naalox) , balance
23 ag/day, periods 6-10
n) patient 1), intake 3.54 ag/day,
balance -10.6 ag/day, periods 11-10
o) 58 yr old, history tnaoral
calcinosis, intake 3.51 ag/aay,
balance -5.2 Bg/daT» periods 1-7
p) Patient o), intake 2899 ag/day
(diet plus Aaphogel and Naalox),
balance 276 Bg/day, periods 8-16
-------
AluainuB
7U29-SO-5
II
At» 26.9815H, HP 660 C, BP 2327 c, VP 1 •• Hg at 1510 C
TISSUE
7081
Synovial
fluid
7082
Synovial
tissue
EXPOSURE RODTE
Ingestion
Ingestion
ANALYTICAL
BETBOD
Pulse- pola rogra ph
J
Polarography
BOBBER
OF CASES
a) 6
b) 1
5
RANGE
a) Not given
b) Not given
a) Not given
b) Not given
BEAN
a) 10.8 »or- 5.0 ug/1
b) 87 ug/1
S.E.
a) 3. 7 ug/g
b) 2.2 ug/g
c) 0.8 *or- 0.2 ug/g
net »t
S.E.
GENERAL INFORMATION
_
a) Controls
b) 48 yr old on 4-10 g daily dose
Al-hydroride for 5 yr
Patient on heiodialysis for chronic
renal failure after transplant
rejection. Controls had not received
Al coapounds.
JDOLTS; BONE DISEASES; KIDNEY
DISEASES; CARTILAGE; SYNOVIAL
BEBBRAHIS: HIBO DIAL YSIS; ALOBINOB
a) 08 yr old on 4-10 g daily dose
Al-hydroxide for 5 yr. Tissue saaple
fron anterior capsule of feaoral head
c) 4 Controls
Patient on henodialysis for chronic
renal failure after transplant
Al compounds
ADOLTS; BOSE DISEASES; KIDNEY
DISEASES; CARTILAGE; SYNOVIAL
BEHBRAUES; HEIIODI AL YSIS; AlCJfllNtTH
REFERENCE
Setter, P.
Burncl, D.
Hutin, B.F.
Kessler, H.F.
Faure, G.
1981
Lancet
1 (8228) : 1056-1057
Netter, P.
Burnel, D.
Hutin, B.F.
Faure, G.
1981
Lancet
1 (8228) :1056-1057
U)
-------
Aluminum
7M29-90-5
Al
Its 26.98150, HP 660 C, BP 2327 C, vp I mm Hg at 1540 C
(COST IS (JED)
TISSDE
7083
Drine
EXPOSOEE BOUIE
Ingestion
ANALYTICAL
BETHOD
A AS
S D« BEE
OF CASIS
6
BANSE
a) 0.051-0.084 ag/day
h) 0.021-0.018 ag/day
c) 0.184-0.255 mg/day
d) 0.053-0.111 mg/day
e) Hot give
£) Not give
g) Hot give
h) Hot give
i) at give
j) at give
k) ot give
1) ot give
a) ot give
n) ot give
o) ot give
p| ot give
q) Bot give
rl Hot given
s) Not given
MEAN
a) 0.066 mg/day
b) 0.033 mg/day
c) 0.221 mg/day
d) 0.080 mg/day
e) 0.098 Big/day
f) 0.282 ig/day
g) 0.338 ng/day
h) 0.229 eg/day
i) 0.230 ag/day
j) 0.200 ag/day
k) 0.051 ag/day
1) 0. 173 mg/day
m) 0.053 mg/day
n) 0.0148 mg/day
o) 0. 139 fig/day
p) 0.076 mg/da;
gj 0.067 mg/day
r) 0.223 ng/day
s) 0.211 mg/day
GZNEBAL INFOPBATION
a) 71 yr old with osteoporosis,
intake 3.28 ing/day, Al balance -0.7
ng/aay, periods 1-5
b) Patient a), intake 5.22 ig/day,
balance 0.3 mg/day, periods 6-10
c) Patient a), intake 1082 mg/day
(diet plus 90 ml/day Haalox), balance
255 mg/day, periods 11-14
d) Patient a), intake 5.09 ag/day,
balance -0.2 mg/day, periods 15-18
e) 69 yr old, intake a.93 ng/day,
balance -21.7 mg/day, periods 1-4
f) Patient e) , intake 1910 ig/day
(diet plus 90 ml/day Amphogel),
balance 247 mg/day, periods 5-7
g) 12 yr old vith osteoporosis,
intake 1219 mg/day (diet plus 90
ml/day Hylanta) , balance 258 mg/day,
periods 1-5
h) Patient g), intake 1250 mg/aay
(diet plus 90 ml/day Bylanta),
balance 92 mg/day, periods 6-9
i) Patient g), intake 1637 mg/day
(diet plus 120 mg/day Hylanta),
balance 250 ng/day, periods 10-14
j) Patient g), intake 3.34 mg/da;,
balance -8.8 mg/day, periods 15-19
k) 54 yr old with osteoporosis and
cerebellar degeneration, intake 5. 15
mg/aay, balance -3.5 »g/aay, periods
1-5
1) Patient k), intake 1081 mg/day
(diet plus 90 ml/day Haaloi), balance
89 mg/aay, periods 6-10
m) Patient k) , intake 5.28 mg/day,
balance -6.0 mg/day, periods 11-15
n) 50 yr old, history of osteoporosis
and alcoholism, intake 3.67 mg/day,
balance -3.9 ag/day, periods 1-5
o) Patient n), intake 1080 mg/day
(diet plus 90 ml/day Haaloi) , balance
23 mg/day, periods 6-10
P) Patient n) , intake 3.54 mg/day,
balance -10.6 ig/day, periods 11-14
q) 58 yr old, history tumoral
calcinosis, intake 3.57 mg/day,
balance -5.2 mg/day, periods 1-7
r) Patient g), intake 2899 mg/day
(diet plus Amphogel and Kaalox),
balance 276 ag/day, periods 8-16
s) Patient g}, intake 2719 mg/day
(diet plus Amphogel and Naalox),
talance 314 mg/aay, periods 17-21
Each period = 6 days
Data mean of all 6 day periods on
constant intake
Al in caraifie (used as stool marker)
included in intake
Haalox, Hylanta, and Amphogel,
commercial antacids containing
12.0-21.2 g Al/1
Volunteers, admitted for evaiuationn
of various medical problems, II
Illinois; ADULTS; BONB DISEASES;
DISEASES; BLOOD PUSHA; OBINE; DRUG
THERAPY; DEOGS; ANTACIDS; ALimiStlH;
BIOACCOHULATIOM; 01EIS
Gorsky, J.E.
Dietz, A.A.
Spencer, B.
Osis, D.
1979
Clinical Chemistry
25(10) :1739-1743
U)
U>
-------
Anthcanilic acid, H-2,3-«ylyl- (8 CI)
Benzole acid. 2-((2, 3-diiethylphenyl)auino)- (9 CI)
61-68-T
C15-B15-H-02
B« 211.28, SP 230-231 C
TISSUE
70 8»
Blood,
plasma
EXPOSOBE ROUTE
Ingestlon
ANALYTICAL
HETHOD
HPLC
NOHBEB
OF CASES
a) 13
b) 12
c) W
d) «
e) 11
£) 18
BAHGB
a) < 1 ug/il
b) 1-10 ag/ml
c) 12-100 ug/il
d) 30-50 ug/Bl
e) 8-150 ug/il
f) 11-100 ug/ml
nthranilic acid, i*-chloro-N-fucfucyl-5-sulfamoyl- (8 CI)
enzoic acid, 5- (aninosulf onyl) -l4-chloro-2-( (2-furanylaethyl) aaino) - (9 CI)
H-31-9
12-H11-C1-82-05-S
» 330.77, »P 206 C
7085
Elood,
serum
7086
Orine
EXPOSOEE ROUTE
In-jec tion
In jection
a) Not given
b) Not given
c) Not given
d) Not given
e) 73 + or- 46 ug/al
f) 38 +or- 24 ug/ml
GENERAL INFORMATICS
a) Below detection limits
b) Therapeutic range
c) No symptoms
A) Muscle twitching
e) Convulsions
f) Ho convulsions
54 patieats reported to have taken
between 1.5 and 50 g 1-18 hr before
initial measurements
Ranges estimated front graph
Overdose patients, 1969-1980,
Scotland
Diarrhea, vo nit ing, muscle twitching,
progressing, in some patients, to
grand oal convulsions
UNITED KINGDOM; BLOOD PLASMA;
ANALGESICS; DHOG ABUSE; DPOG
INTERACTION; DRUGS
Balali-flood, M.
Proudfoot, A.T.
Critchley, J.A.J.H.
Prescott, 1.P.
1981
Lancet
1 (82341 :1354-1356
LYTICAL
ETHOD
•etcy
NOHBEB
OF CASES
8
18
BANGE
a) 9-0. 15 ug/ml
b) 10-0.3 ug/ml
a) Hot given
b) Hot given
c) Hot given
d) Hot given
a) Not given
b) Not given
a) 28.08 *or- 2.60 mg
b) 24.00 +or- 0.74 mg
c) 23.64 *or- 2.03 mg
d} 26.94 +or- 2.30 jg
(NEXT PAGE)
GENEEAL INFORMATION
a) 5 and 360 Bin after 40 ig IV
b) 5 and 360 min after 40 mg IV, plus
indomethacin (100 ag about 8 hr
before and 100 mg 30-60 min before
f urosemide)
Range of means, estimated from graph
Healthy 22-27 yr olds, 50.0-86.2 kg
BLOOD SERUH; ANALGESICS; DIORETICS;
DHOG INTERACTION; DRUGS
a) Moderate congestive heart failure
(8 sub-jects)
b) Advanced congestive heart failure
(10 sublects)
c) As in b) (8 subjects)
d) As in b) , with 0.2 mg/kg
hydralazine
6 hr cumulative output after 40 mg
Diuretic effect correlated with urine
level and augmented by hydralazine
29-64 yr old cardiac patients
CARDIOVASCULAR DISEASES; ORIHB;
DIURETICS; DRUG THEEAPY; DROGS; JAPAS
I
LO
OJ
*-J
Chennavasin, P.
Seiwell* R.
Brater, O.c.
1980
Journal of Ptiarmacology
and Experimental
Therapeutics
215(1) :77-81
Nomura, A.
Yasuda, H.
linami, H.
Akiraoto, T.
Hiyazaki, K.
Arita, T.
1981
Clinical Pharmacology
and Therapeutics
30(2) : 177-182
-------
Jnthranilic acid, ll-chloro-N-f urf uryl-5-sulf aioyl • (8 CI)
Benzole acid, 5- (aninosulf onyl) -H-ckloro-2- ( (2-f uranylaethyl) anlno) - (9 CI)
51-31-9
C12-BI1-C1-82-05-S
B« 330.77, HP 206 C
(CONTINUED)
TISSUE
7087
Orine
EXPOSDRE BOOTE
Injection
ANALYTIC*!,
BETHOD
HPLC
NOBBEB
OF C»SES
8
BINGE
a) Hot given
b) Not given
c) Hot given
d) Hot given
BEAN
a) 9.3 »or- 1.1 jig
b) 9.4 »oc- O.H ig
c) 19.7 »or- 2.2 og
d) 18.8 *oc- 1.7 ag
GENERAL INFORMATION
a) 24 hr emulative excretion after
20 mg
b) Same as a) , plus indonethacin (100
•g about 8 hr before and 100 mg 30-60
• in before furosemide)
c) 21 hr emulative excretion after
QO mg
dj Same as c) plus indoaethacin as in
b)
No significant differences between a)
and b) and c) and d)
Healthy 22-27 yr olds, 50.0-86.2 kg
BIOOO SESU«: ANJIGESICS; DIURETICSJ
DBOG IXTBBUCTION; DRUGS
Chennavasin, p.
Seiwell, R.
Brater, o.C.
1980
Journal of Pharmacology
and Experimental
Therapeutics
215{1):77-81
»ntipyrine (8 CI)
3H-Pyrazol-3-one, 1.2-dihydro-1,5-di«ethyl-2-phenyl- (9 CI)
60-80-0
C11-H12-N2-0
B» 188.22, HP 111-113 C
TISSOE
7088
Blood,
plasia
7089
Blood,
plasna
EIPOSDRE ROOTS
Injection
miYTICUL
BETHOD
Photometry
nan ECS
OF CASES
3
a) 1
b) 1
BINGE
a) 60-30 ug/2 ml
b) 50-12 ug/2 ml
c) "12-1 1 ug/2 ill
d) 65-35 ug/2 »1
e) 50-22 ug/2 il
a) 50-15 ug/ll
b) 70-6 ug/Bl
.
BEAN
a) Not applicable
b) Not applicable
c) Not applicable
d) Hot applicable
e) Not applicable
a) Not applicable
b) Not applicable
GENERAL INFORMATION
a) Pb poisoned, exposure unknown,
blood Pb 60 ug/100 »1
b) After chelation therapy, blood Pb
20 ug/IOQ ml
c) Sibling of a), not Pb poisoned
4) Pb poisoned, exposure unknown,
blood Pb 72 ug/100 nl
e) After c halation therapy. 52 ug
Pb/100 ml
Estimated from graph
3 and 18 hr after unspecified dose
2.0-3.5 yr olds
CHILDREN; LEAD POISONING; BETAL
POISONIHG; BLOOD; BLOOD PLASBA;
DRUGS; LEAD; METALS; METABOLISM
a) Oral contraceptive user
b) Control
Initial measurement and 25 hr after
1.0-1.2 g dose
Actipyrine clearance i•paired by oral
contraceptive steroids
BLOOD PLASMA; SEDATIVES;
ANTIPYRETICS; DRUG INTERACTION; DRUG
THERAPY; DROSS
REFERENCE
Alvares, A.P.
Kapelner, S.
Sassa, 5.
Kappas, A.
1975
Clinical Pharmacology
and Therapeutics
17(21:179-183
Abernethy, D.8.
Greenblatt, D.J.
1981
Clinical Pharmacology
and Therapeutics
29(1):106-110
OJ
U)
CO
-------
Antipyrine, 1-(di«et bylaiino) - (8 cl)
3H-Pjrazol-3-one. »-(diBethylaBino)-1,2-dihydro-1,5-ai«ethyl-2-phenyl- (9 CI)
58-15-)
C13-S17-M3-0
B« 231.29, BP 107-109 C
TISSUE
7090
Breath
EXPOSOBE EOOTE
Injection
ANALYTICAL
HETflOO
Badioaetry
SOB BBS
OF C1SE5
a) 115
b) 19
c| 22
d) 46
e( 9
BINGE
a) 5-10%
b) 6. 1-1 7*
c) 0.8-«. 5%
d) 0.8-7*
e) 3.5-8.2!(
_
a) 6.2%
b) 9.1%
c) 2.5%
d) 3.5%
e) 6%
GENERAL IHFOBHtTIOH
a) Controls
b) Patients on anticonvulsants
c) Patients tilth hepatocellular
disease
d) Patients vith hepatic neoplasBS
e) Patients with cholestasis
2 hr output of C-1» after 1 uCi
Significant increase in b) and
decrease in c) and d)
Estinated froB graph
43-57 yr old hospital patients
Confusion or dysarthria occurred in
cue control and 8 patients with
hepatocellular disease
BREATH; CIBBHOSIS; LIVEB DISEASES;
UEIHE; ANALGESICS; ANTICOKTOLSANTS;
ANTIPYBJTICS; OBOG INTEBACTIOH;
DEUGS; TSANQOILIZEHS; COBPABATIVE
EVALUATIONS
Hepner, G.w.
Vesell, E.s.
Upton, A.
Harvey, H.A.
Wilkinson, G.B.
Schenker, s.
1977
Jcarnal of Laboratory
and Clinical ledicine
90 (3) : 110-456
Asparaginase
9015-68-3
EXACT COHPOSITIOH OBKHOSH OB nBDBTEBBINED
TISSOE
7091
Blood,
plasna
7092
Orine
.
EXPOSOBE BOOTE
Injection
Injection
ANALYTICAL
BETHOD
Badioaetry
BadioBetry
HUHBEB
OF CASES
a) 1
b) 5
c) 1
d) 1
e) 1
a) 7
b) 5
BADGE
a) Hot applicable
b) 11. 6-28.0 10/Bl
c) Hot applicable
d) 0.20-1.10 I0/«l
e) Hot applicable
a) Hot given
b) None detected
HEAH
a) 8.3 10/Bl (83%)
b) 22.7 10/Bl (76%)
c) 37.8 IO/.1 (63%)
d) 0.88 Id /ml (15%)
e) 0.04 10/Bl < IV
d) After 10,000 I0/sq m in (peak
level)
level)
* of dose
Patients «ith leuteBia and Betastatic
cancer, vt 50-127 kg
AHTITONOB AGENTS; AOOITS; CABCIHOBAS;
LEOIC5BIA: NEOPLASBS; OSTEOSABCOBAS ;
ELOOD PLASBA; OBINE; DBUGS ;
CCHPABATIVE EV1IDATI09S; SHZIBBS
a) Excreted within 24 h after
16,500-100,000 ItJ/sq », IV
b) Excreted within 3 d after
10,000-20,000 I0/sg n, in
% of dose
Patients with leukeaia and Betastatic
cancer, wt 50-127 kg
AKTITUBCB AGENTS; ADOITS; CABCIS08AS;
lEHKEBIA; NBOPLASBS; OSTEOSABCOBAS;
ELOOD PLASHA; HEINE; DRUGS;
COBPABATIVE EVALOATIORS; ENZYBES
BEFEBENCE
Ho, D.H.H.
Tap, H.Y.
Brown, N.
Benjaain, P.S.
Friereich, E. J.
Bodey, S.P.
1981
Journal of clinical
Pharaacology 21:72-78
Ho, D.H.a.
Yap, H.Y.
Brown, N.
Benjaain, H.S.
Friereich, E.J.
Bluaenschein, G. B.
Bodey, G.P.
1981
Journal of clinical
Pharmacology 21:72-78
-------
Barbituric acid, 5-(1-cyclohexen-1-yl)-1,5-dimethyl- (8 CI} n«uj
2,11,6 (1H, 3H, 5H)-Pyrimidinetrione, 5-{1-cyclohexen-l-yl)-1,5-dimethyl- (9 CI}
E6-29-1
C12-H16-K2-03
US 236.26, «P 1H5-117 c
TISSUE
7093
Blood,
plasma
EXPOSURE ROUTE
Ingestion
ABALY.TICAL
BETH OB
SC
SOHBEB
OF CASES
6
BINGE
1.2-0.5 ug/ml
nets
Mot given
GENERAL IBFORBATION
5 and 2<* he after SCO ag on day 1 of
a s day study during which time
(C£D) every 1 hr. Initial
measurement 0.03 ug/nl at 30 vin.
after CBD treatment, peak levels were
as much as 50% lower
Range of means, estimated from graph
Healthy 21-28 yr olds
Increased fatigue, and tremor.
impaired eye tracking performance.
and altered electro encephalogram.
Effects not altered by CBD.
BIOOD P1AS(!«; DRUG IHTEFACTIOII:
DBOGS; HYPNOTICS; PSICHOTROPIC DBOGS;
SEDHTIVES; COHPAEiTIVE EVAIOATIOSS;
MITABOLISM
EEFEEEHCE |
Benowitl, N.L.
Nguyen, T.R.
Herning, E.I.
Sachnan, J.
Clinical Pharmacology
and Therapeutics
28(1> -.115-120
Barbituric acid, 5-(l-cycloheien-1-yl)-5-ethyl- (8 CI)
2rO,6(lH,3H,5B|-pyrimidinetrione, 5-(1-cyclohe*en-1-yl)-5 ethyl- (9 CI)
52-31-3
C12-H 16-112-03
«B 236.26, IIP 171-171 C
TISSDE
7094
Blood
7095
Brain
7096
Liver
EIPOSOBE ROOTE
ASA1YTICAL
METHOD
SC
0V
GC
ov
ec
ov
NOHBEB
OF CASES
1
1
1
BARGE
a) Hot applicable
b) not applicable
a) Hot applicable
b) Hot applicable
.
a) Hot applicable
b) Hot applicable
BEAN
a) 1. 1 jig/IOOg
b| 1.4 «g/100g
a) 0.5 mg/IOOg
ft) 0.8 mg/100g
a) 1.3 mg/lOOg
b) 0.9 mg/100g
SEHE5AL ISFOBBATICH
a) solvent extraction aethod
b) XAO-2 resin bag extraction method
Fatal overdose case
Poland
POLAKD; BLOOD; BEAIH; LlfEB: DRUG
ABUSE; DRUGS; BEASdREnEHT BBTHODS
a) Solvent extraction method
b) JfAD-2 resin bag extraction aethod
Fatal overdose case
Poland
POLAND; BLOOD; BEAIH; LITEE; DROO
AEOSE; DROGS; BEASOREBEHT BETHODS
a) Solvent extraction aethod
b) TAD-2 resin bag extraction method
Fatal overdose case
Poland
POLAHD; BLOOD; BE»I»; LIVES; DRUG
ABUSE; DRDOS; BEASOREHEHT BETHODS
REFERENCE
Bogusz, H.
Gierz, J.
Bialka, J.
1978b
Forensic Science
International 12:73-82
Bogusz, B*
Gierz, J.
Bialka, J.
1978b
Forensic Science
International 12:73-82
Bogusz, tl.
Gierz, J.
Bialka, J.
1978b
Forensic Science
International 12:73-82
-------
Barbituric acid. 5-allTl-5-(1-«ethylbutyl|- (8 CI)
2.1,6 (lH,3H,5H)-Pyri«idinetrione, 5- (1-«ethylbutyl) -5- (2-propenyl) - (9 CI)
76-73-3
C12-H18-H2-03
H« 33D
TISSUE
7097
Blood
7098
Blood
7099
Blood
7100
Urine
EIPOSDRE BOOTE
Ingestion
. ...
Ingestion
ANALYTICAL
8ETHOD
SC
TLC
0V
GC/HS
Enzymatic
GC
UV
BIA
BOBBISH
OF CASES
2
15
5
1
BANGB
3.6-23.5 «g/l
a) 1.5-6.6 ug/il
b) 1.5-4.1 ug/«l
c) 1.1-5.6 ug/»l
d) 1.3-5.3 ag/il
0.11-0.7 mg/100 Hi
Hot given
1
HEAD
Not given
a) 3.1 +or- 0.7 ug/al
b) 2.1 *or- 0.4 ug/ml
c) 3.5 tor- 0.1 iig/nl
d) 2.8 »or- 0.6 ug/«l
Hot given
>500 ug/1
GENERAL INFORnATION
Dose probably sufficient tc
contribute to signs and syaptoas
Results from 1 laboratories receiving
identical saaples for toxic screen
Overdose drugs identified in 50J-70X
of cases
Laboratories agreed on 6 of 23 drugs
patients
Levels were variable and appeared
inprecise .
Probable drug overdose patients.
Boston, HA
HASSACHUSETTS; BLOOD; ANALGESICS;
ASTICOHTULSAHTS; 1NTIDEPRESSITE
AGESTS; ANTIPYRETICS; DEJG ABUSE:
DSUGS; HYPNOTICS; NARCOTICS;
SEDATIVES; TRANQUILIZERS; COBPARATI7E
EVALUATIONS; ALCOHOLS; lEASUBEflENT
BETHODS
a) 6 controls, toxic level
b) 6 controls, 7 hr after last dose
c) 9 patients, toxic level
d) 9 patients, 7 hr after last dose
Hean dose 672 tai- 65 mg Tuinal (50*
secobarbital and 50t anobarbital by
«or- 169 «g Tuinal/150 Ib for
patients. Dose schedule 100-200 ng
total barbituate/hr until tonic level
reached
17-35 yr old secobarbital/avobarbital
drug abusers and controls
Drowsiness, slurred speech, ataxia.
and combination of vertical and
BLOOD; DBUG AB0SE; DRUG INTERACTION
DPUGS; HYPNOTICS; PSYCHOTROPIC DBUGS;
SEDATIVES
Crug induced fatalities, ethanol (5
cases, 0.07-0.32 g/100 ml) and
phenobarbital (1 case, 0.20 ag/100
ol) also found.
Autopsies, 1975-76, Los Angeles
county, CA
CALIFORNIA; AUTOPSIES; CASE
HISTORIES; BLOOD; D ROG ABUSE; DRUGS;
FORESSIC MEDICINE; ALCOHOLS
1-72 hr after 100 »g
Volunteer
URIBE; DRUGS; HYPNOTICS; NARCOTICS;
HEASHREHEST HETHODS
REFERENCE
Ingelfinger, J.A.
Isakson, G.
Shine, D.
Costello, C.E.
Gold Ban, P.
1981
Cli&ical Pharnacology
29(5):570-575
Faulkner, T.P.
ncSinity, J.w.
Hayden, J.H.
Olsen. D.A.
Coustock, E.I.
1979
Pharaacology
19(10) :605-616
Nakanura, G.B.
Noguchi, T.T.
Griesener, B.C.
1979
Toxicology 3:137-112
Osategai-Goaez, n.
Heveran, J.E.
cleelaod, K.
KcGhee, B.
Telischak. Z.
Awdziej, T.
Grunberg, E.
1975
Clinical Chemistry
21 (10): 1378-1382
UJ
.p-
-------
Sarbituric acla, S-allyl-5-isobutyl- (8 CI)
2,4,6(1H,3H,5H)-Pyriiidinetrione, 5- (2-»ethylpropyl)-5-(2-propeoyl) - (9 CI)
77-26-9
C11-H16-H2-03
B» 224.3, HP 137-140 C
TISSUE
7101
Blood
EXPOSURE ROUTE
AKALmcAt.
BETHOD
ec
TLC
UV
SC/SS
Enzymatic
SUHBES
OP CASES
a) 0-8.0 »g/l
b) 0-13.0 ig/1
GENEBAL IBFOBBiTICII
a) Hot given
b) Hot given
a) Dose probably sufficient to
contribute to signs and sy»pto«s
b) Doses probably less than toxic
avounts
Results fro» 4 laboratories receiving
Identical samples for toxic screen
Overdose drugs identified in 50*-70*
of cases
laboratories agreed on 6 of 23 drugs
reported present in serua of 20
patients
levels were variable and appeared
inprecise.
Probable drug overdose patients.
Boston, BA
IIASSACHUSETTS; BLOOD; ANALGESICS;
AKTICOSVULSANTS; ISTIDEPBESSI'S
AGENTS; ANTIPYRETICS; DBOG ABUSE;
DEaGS; HIPKOTICS; NARCOTICS;
SEDATIVES; TEANOOILIZEES; COHPARATIvE
EV»LO»TIO»S; ALCOHOLS; SEASOBEBEKT
HETHODS
Ingelfinger, J.A.
Isafcson, G.
Shine, D.
Costello. C.E.
Goldian, P.
1981
Clinical Pharnacology
and Therapeutics
29(5):570-57-;
Barbituric acid, 5-ethvl-5-(1-»ethyt-1-butenyl) - (8 CI)
2,«,6(1B,3H,5H)-Pyri»idinetrione, 5-ethyl-5- (1-«ethyl- 1-batenyl) - (9 CI)
125-U2-8
C11-H16-II2-03
H» 22K.3, DP 160-163 C
N3
TISSUE
7102
Blood
7103
Kidney
7101
Llv«r
7105
urine
El EOS ORE ROUTE
Ingestion
Ingestion
luges tion
Ingestion
ANALITICAL
BETHOD
TLC
Coloriietr;
TLC
Colorivetry
TLC
Color i.etrj
ILC
NOBBER
OF CASES
1
-
1
1
1
BADGE
Not applicable
Not applicable
Hot applicable
Hot applicable
-
HE AS
5.3 ig/100 «1
8.5 ig/100 ag
16. II «g/100 >g
8.0 mg/100 mi
GENERAL INFORtlATIOR
Dnknovn dose
75 yr old suicide victim
AOTOPSIESj SUICIDE; BLOOD; KIOHETS;
LITER; ORIHE; OR OS ABDSE; DBOGS;
FORENSIC BEDICIHE
Unknown dose
75 yr old suicide victu
AUTOPSIES; SUICIDE; BLOOD; ICIDRETS;
LITEF: D8INE; DRUG ABUSE: DRUGS;
FORENSIC HECICIHE
75 yr old suicide victi«
AUTOPSIES; SUICIDE; BLOOD; KID«BTS;
LIVEB; URINE; DRUS ABUSE; DRUGS;
FORENSIC BIDICIHE
U&knovii dose
75 yr old suicide victii
iOTOPSIES; SUICIDE; BLOOD; KIDNEYS;
IITER: HEINE; DRUG ABUSE; DRUGS;
FOBEICSIC HEDICIHE
REFERENCE
PoKlis, A.
Haneli, ».Z.
1975
Archives of Toxicology
3»: 77-80
Poklis, A.
Haieli, A.Z.
1975
Archives of Toxicology
34:77-80
Poklis, A.
Ha.eli. A.Z.
1975
Archives of Toxicology
34:77-80
Poklis, A.
Haieli, A.Z.
1975
Archives o£ Toxicology
34:77-80
-------
Barbituric acid, 5-ethyl-5-(1-«ethylbutyl)- (8 CI)
2,»,6(1H,3H.5B)-Prriiidinetrione, 5-ethyl-5-(1-iethylbiityl)- (9 CI)
76-71-11
C1I-H18-H2-03
B« 226.31
TISSUE
7106
Bile
7107
Blood
7106
Blood
7109
Blood
7110
Blood,
plasaa
7111
Blood,
plasma
EXPOSURE ROUTE
Injection
Ingestion
Ingestion
Infection
Ingestion
Ingest ion
Ingestion
MAI.TTICAL
HETHOD
GC
coloriaetry
TLC
GC
nv
sc
sit
HOHBEE
OF CASES
2
1
2
6
6
7
RANGE
111-3480 ug/al
Not applicable
113-173 ug/nl
0.4-0.8 B.g/100 »1
a) Hot given
b) Hot given
c) Mot given
1.2-2,1 ug/«l
HE AM
Not applicable
15 ag/100 •!
Not applicable
Sot given
a) 2.60 +or- 0.63
ug/al
b) 1.98 +or- O.(i8
ug/al
ug/nl
Hot given
GENERAL IHFORHATIOI,
Suicide victias, dose unknown
38 yr old Caucasian and 32 yr old
East Indian, CA
Congestion and edeaa of langs
CALIFORNIA; ADULTS; SUICIDE; BIIE;
BLOOD; BBAIN; HEART; KIDKEYS; LIVEH;
LONGS; URINE; DFOG ABUSE; OBOGS;
HYPNOTICS; SEDATIVES
Estimated absorbed dose 1. 5 g
Suicide victim
AUTOPSIES; SOICICE; BLOOD; KIDNEYS;
LIVER; DEOG ABUSE; DRUGS
Suicide victins, dose unknown
38 yr old Caucasian and 32 yr old
East Indian, CA
Congestion and edeaa of lungs
CALIFORNIA; ADULTS; SUICIDE; BILE;
BLOOD; ERAIH; HEART; KIDNEYS; LIVER;
IUHGS; DRIHE; DRDG ABUSE; DRUGS;
HYPNOTICS; SEDATIVES
Drug induced fatalities. Ethanol (6
cases, 0.02-0. 35 g/100 nl) and
propoxvphene (1 case, 0.12 ag/100 al)
also found.
Autopsies, 1975-76, Los Angeles
County, CA
CA1IFOPHIA; AUTOPSIES; CASE
HISTORIES; BLOOD; DRUG ABUSE; DRUGS;
FOBEHSIC BEDICIHE; ALCOHOLS
a) Before
delta-9-tetrahyflcocannabinol (THC)
b) During THC
c) After THC
It days
Healthy 20-29 yr olds
E1COD PLASBJ; DEDG IHTEBACTIOH;
DEDGS; SEDXTIVES; 1ETABOLISB
9 hr after 100 ng on day 1,8, 15
during 14 day study with one dose per
night
Fange of Beans
Healthy 21-60 yr olds with sleep
difficulties
Slightly reduced sleep latency, but
of wakings. No effect on psychoaotor
performance.
BLCOD PLASflU; DEOG TBEEAPy; DBOGS;
HIPHOTICS
BEFEBEHCE |
Shaw, B.F.
1981
Clinical Toxicology
18 (8): 965-968
Poklis, A.
Haneli, A.Z.
1975
3»:77-80
S haw , B . P .
1981
Clinical Toxicology
18(8) : 965-968
Nakamura, G.R.
tioguchi, T. T.
GrieseBer, E.C.
1979
Journal of Analytical
Toxicology 3:137-112
Benovitz, N.L.
Jones, E.T.
1977
Clinical Pharnacology
22 (3) :259-268
Linnoila, B.
Erwin, C.iT.
Brendle, A.
1982
Journal of clinical
Pharmacology 22:11-19
(KBIT PAGE)
U)
js
U)
-------
Barbituric acia, 5-ethyl-5-(1-»ethylbutyl)- (8 CI)
2,»,6(1H,3H,5H)-Pyi:iiidinetrione, 5-ethyl-5- (1-»ethylbutyl) - (9 CI)
76-7U-1
C11-H18-N2-03
BV 226.31
(CONTIHUED)
TISSUE
7112
Bra io
7113
Heart
711»
Kidney
7115
Kidney
Liver
7117
Liver
EXPOSURE ROUTE
Infection
IngestioB
Ingestion
Ingestion
Injection
Ingestion
Infection
Ingestion
ANALYTICAL
HETHOD
GC
GC
ColoriKtry
TIC
GC
TIC
_
GC
HOUSES
OF OSES
2
1
1
2
2
EAHGE
100-112 ug/g
Not applicable
Not applicable
190-1457 ug/g
-
._
158-1580 ug/g
BEAN
Mot applicable
180 ug/g
6.3 ag/100 Kg
Not applicable
Not applicable
(NEXT PAGE)
GENERAL ISFOR8ATION
Suicide victims, dose unknown
38 yr old Caucasian and 32 yr old
East Indian, CA
Congestion and edeaa of lungs
CJLIPORSIl; JDDITS; SUICIDE; BI1E;
BIOOD; BRAIN; HEABT; KIDNEYS; LIVER;
LONGS; DKIBE; DBOG ABUSE; DRUGS;
HYEHOTICS; SEDATIVES
Suicide victi>, dose unynown
32 yr old East Indian, CA
Congestion and edema of lungs
CALIfORNIA; ADULTS; SUICIDE; BILE;
BLOOD; BBJIH; HEART; KIDNEYS; LIVE5;
IDNG5; URIHE; DRUG ABUSE; DBUGS;
HYPNOTICS; SEDATIVES
Estimated absorbed dose 1.5 g
Suicide »icti«
AUTOPSIES; SUICIDE; BLOOD; KIDNEYS;
LIVEE; DRUG ABUSE; DRUGS
Suicide victifts, dose unknown
38 yr old Caucasian and 32 yr old
East Indian, CA
Congestion and edeia of lungs
CALIFORNIA; ADULTS; SUICIDE; BILE;
BLOOD; BRAIB; HEART; KIDNEYS; LIVER;
LONGS; UBItlE; DBOG ABUSE; DRUGS;
HYPSOTICS; SEDATIVES
Estimated absorbed dose 1.5 g
Suicide victi«
AUTOPSIES; SUICIDE; BLOOD; KIDNEYS;
LIVER; DRUG ABUSE; DRUGS
Suicide victims, dose unknown
38 yr old Caucasian and 32 yr old
East Indian, CA
congestion and edeaa of lungs
CALIFORNIA; ADULTS; SUICIDE; BILE;
BLOOD; BBiI»; HEIST; KIDSIYS; LIVER;
LDHGS; URINE; DROG ABUSE; DRUGS;
HYPNOTICS; SEDATIVES
Shaw, R.F.
1981
Clinical Toxicology
18(8) : 965-968
Shaw, R.F.
1981
Clinical Toxicology
18(81:965-968
Poklis, A.
Haieli, A.Z.
1975
Archives of Toxicology
34:77-80
Shaw, R.F.
1981
Clinical Toxicology
18(8) :965-968
PoUis, A.
HaKli, A.Z.
1975
Archives of Toxicology
31:77-80
Shav, R.F.
1981
Clinical Toxicology
18(8):965-968
-------
Barbituric acid, 5-ethjl-S-(1-ietUylbutyl)- (8 CI)
2,1,6(1H,3H,5H)-pyri»idinetrione, 5-ethyl-5-(1-«ethylbutyl)- (9 CI)
76-71-1
C11-H18-N2-03
an 226.31
(CONTINUED)
TISSDE
7118
Lung
7119
Orine
7120
Orine
EIPOSOBE BOOTE
In jection
Ingestion
Ingestion
Injection
Ingestion
ANALYTICAL
HETHOD
GC
Coloriaetry
GC
BUB BEE
OF C1SES
2
2
BINGE
.
148-217 ug/g
2-17 ug/«l
._.
8.3-115 ug/al
BEAN
Not applicable
Not given
Not applicable
GENERAL INFORDtTICN
Suicide victias, dose unknown
38 yr old Caucasian and 32 yr old
East Indian, CA
Congestion and edeaa of lungs
CALIFORNIA: ADULTS; SOICIDE: BILE;
BLOOD; BBAIN; HBABT; KIDNEYS; LITEB;
LUNGS; URINE; DBUG ABUSE; DBUG5;
HYESOTICS; SSDATIVES
1 and 8 hr after 100 nq. Final
•easuceoent 10 ug/Bl at 12 hr.
Estinated fro* graph. Data corrected
to urine relative density of 1.021.
OFIHS; DBOGS; HYPNOTICS; SEDATIVES;
nEASDREIIENT BEIHODS
Suicide victins^ dose unknown
38 yr old Caucasian and 32 yr old
East Indian, CA
Ccngestion and edena of lungs
CALIFOfiNIl; ADULTS; SUICIDE; BIIS;
BLOOD; ERAIN; HEABT; KIDNEYS; H7BB;
LUNGS; UBINE; DEUG ABUSE; DBOGS;
HYPNOTICS; SEDATIVES
Shaw, B.F.
1981
Clinical Toxicology
18(8):965-963
Pehr, F.
1975
Clinical Chemistry
21(11): 1609-1611
Shaw, B.F.
1981
Clinical Toxicology
18 (8) :965-968
Barbituric acid, 5-ethyl-5-isopentyl- (8 CI)
2,tt,6(1H,3H,5H)-Pyriliiinetrione, 5-ethyl-5- (3-«ethylbutyl)- (9 CI)
57-13-2
C11-H18-S2-03
H« 226.27, BP 156-158 C
TISSUE
7121
Blood
EX POSO BE ROUTE
Ingestion
ANALYTICAL
METHOD
GC
NDBBEB
OF CASES
15
BANGE
a) 2.3-7.6 ug/al
b] 2.0-5.2 ug/al
c) 2.7-9.7 ug/al
d) 2.11-8.7 ug/al
HEAN
. .. _
b) 3.0 *or- 0.5 ug/ai
d) ». t *or- 1.0 ug/al
GESEBAL IKFOBBATION
b) 6 controls, 7 hr after last dose
d) 9 patients, 6 hr after last dose
Bean dose 672 *or- 65 »g Tuinal (50*
secobarbital and SOT anobarbital by
+OE- 169 mg Tuinal/150 lb for
patients. Dose schedule 100-200 >g
total barbituate/hr until toxic level
reached
17-35 yr old secobarbital/a«obacbital
drug abusecs and controls
Drowsiness, slurred speech , atari a.
lateral nystagmus
BIOOD; DBOG ABDSE; DROG INTBR&CTIOH;
DROGSJ HYPNOTICS; PSYCHOTROPIC DROGS;
SED&TIVES
REFEBEHCE
Faullcner, T.P.
WcSini ty, J.fr.
Hayden, J.H.
Olsen, D.A.
COBStOCk, E.G.
1979
Journal of clinical
Pharmacology
19 (10) :605-616
(NEXT PAGE)
-------
Barbituric acid, 5-ethyl-5-lsopentyl- (8 CI)
2.4,6(1H,3H,5H)-pyrimidinetrione, 5-ethyl-5-(3-methylbutyl)- (9 CI|
57-43-2
C11-H18-H2-03
fl» 226.27, HP 156-158 C
(COBTMDED)
TISSOE
7122
Blood ,
plasma
7123
Drine
EXPOSURE EOOTB
lagestion
Ingestion
ANALYTICAL
BETHOD
colorimetrv
HUBBgB
OP CASES
Mot given
4-16
it.5 ug/ml
Hot given
GESEBAL IHTOBBATIOH
6 hr after 1 g Amoquine (^90 mg
dihydroguinidine, <*10 sg amobatbital)
16 yr oia
Headache, vertigo, sleepiness,
photophobia, sinus tachycardia (125
kpa) at admission 6 hr after dose.
SEIGIOB; ADOLESCESTS; CASE HISTORIES:
BLOOD PLASBJ; OEI»E: AHTI1RRHTTBIIIC
JGINTS; DEOG ABOSE: DRUGS; LAVUGE
1 and 7 hr after 400 mg. Final
Measurement 12 ug/Bl at 12 hr
Estinated from qraph
ftesults corrected to a urine relative
density of 1.024.
URINE; DEDGS; HtPSDTICS; SEDATHES;
BEASDBEBE8T BETHODS
Lesne, n.
Deios, D.H.
Reynaert, M.
1981
Clinical Toxicology
IB (6): 659-662
Pete, P.
1975
Clinical chemistry
21 (11) : 1609-1611
Barbituric acid, 5-ethyl-5-phenyl- (8 CI)
2,«,6(1H,3H,5H)-pyrimidinetrione, 5-etnyl-5-phenyl- (9 CI)
50-06-6
C12-B12-N2-03
a» 232.23, BP 174-178 C
TISSOE
7124
Blood
EXPOSURE POUTE
XNiLTTICAL
HETHOD
GC
TLC
DV
GC/HS
Enzyaatic
KOBBER
OP CASES
2
EAHGE
50.0-77.0 «g/l
BEAB
Hot given
GESEEtL IHFORmtTION
Dose probably sufficient to
contribute to signs and syiptoss
Results frOB 4 laboratories receiving
identical samples for toxic screen
Overdose drugs identified in 50H-70*
of cases
Laboratories agreed on 6 of 23 drugs
patients
levels were variable and appeared
imprecise.
Probable drug overdose patients,
Boston, MA
BASSACROSETTS; BLOOD; ANALGESICS;
ARTICONVOLSANTS; AHTI DEPRESSIVE
AGniTS; AHTIPISEIICS; DSOS ABOSI;
DEOGS; HTPBOTICS; SASCOMCS;
SEDATIVES; TRABQOILIZEES; COSPAHATIVE
HVALOATIOHS: ALCOHOLS; SEASOBEMENT
HEIHOOS
U>
*-
OS
(HSIT PAGE)
ng
»
s
VE
REEEREBCE
Ingelfioger, J.A,
Isakson, G.
Shine, D.
Costello,
Goldman,
1981
Clinical
C.E.
P.
Pharmacology
and Therapeutics
29(51:570-575
-------
Barbituric acid, 5-ethyl-5-phenyl- (8 CI)
2,4,6(1B,3H,5B)-pyriaidinetrione, 5-ethyl-S-phenyl- (9 CI)
50-06-6
C12-B12-N2-03
US 232.23, HP 174-178 C
(CONTINUED)
TISSUE
7125
Blood
7126
Blood
7127
Blood,
EXPOSURE BOOT!
Ingestion
ANALYTICAL
HETBOD
0»
GC
GC
HtfflBEB
or CJSES
11
1
a)
t>>
d)
e)
f)
9)
hi
i)
1)
BADGE
0.5-7.D ag/100 »1
Hot applicable
a) Not applicable
b) Hot applicable
4) Not applicable
e) Not applicable
f) 26-2 ug/ll
g) 40-9 ug/al
h) 7-1.5 ug/al
i) 8-3.5 ug/.l
J) 10-0.2 ug/al
HEAH
Not given
0.4 mgt
a) 25.3 ug/al
b) 31.1 ug/al
d) 11.0 ug/.l
e) 10.5 ug/al
f) Not given
g) Not given
h) Not given
i) Not given
j) Not given
GENERAL INFORBATION
Drug induced fatalities. Ethanol (9
cases, 0.01-0.38 g/100 ml).
secobarbital (1 case, 0.2 ag/100 all.
ethchlorvynol (1 case, 0.34 ag/100
• 1) , aaobarbital-secobarbital (1
case, 0.6 ng/100 al) , phenytoin (1
case, 0.1 ag/100 ol), and
diphenhydraa (1 case, 0.01 «g/100 •!)
also found.
Autopsies, 1975-76, Los Angeles
Ccunty, CA
CALIFORNIA; AUTOPSIES; CAS I
HISTOEIES; BLOOD; DBUG ABOSE; DBOSS;
FCSEHSIC MEDICINE; ALCOBOLS
Driver fatally injured in single-car
crash. Blood alcohol 30 ag*
North Carolina
NOBTH CAROLINA; BLOOD; DEOG ABOSE;
DRUGS; ALCOBOLS
a) Mother, at delivery, dose 100 ag
b) Bother, at delivery, dose 2QO ag.
trinester
e) Mother, at delivery, dose 75 mg
f) Infant of a), 12 hr-15 day after
parturition, cord blood level 21.8
ug/al
g) Infant of b) , 12 hr-10 day after
parturition, cord blood level 35.8
ug/«l
h) Infant of c) , 12 hr-9.5 day after
parturition, cord blood level 5,4
ug/al
i) Infant of d) , 18 hr-7 day after
parturition, cord blood level 9.2
ug/al
j) Infant of e) , 36 hr-15 day after
parturition, cord blood level 10.0
ug/al
Daily dose during pregnancy with last
dose 2.5-12.5 hr before delivery
in 3 of 5 newborns
f)-j) estimated from graph
Epileptic aothers and their full-tera
JAPAN; ADOLTS; NESBOBN; CENTBAL
SEB70US SySTEB DISEASES; BLOOD
PLJSBA; AWICOHVOLSAI'TS: DRDGS;
BTPNOTICS; SEDATIVES; PBEGNANCT; DEDG
THERAPY
REFERENCE
Nakaaara, Q.B.
Noguchi, T.T.
Grieseaer, B.C.
1979
Journal of Analytical
Toiicology 3:I37-1«2
Turk, 8.F.
McBay, A.J.
Budson, P.
1974
Sciences 19(l):90-97
Ishizaki, I.
Tokochi, Jt.
Tabuchi, T.
Hagatsuaa, T.
1981
Pediatric Pharnacology
1:291-303
U)
.p-
(NEXT PAGE)
-------
Barbituric acid, 5-«thyl-5-phecyl- (8 cl)
2,1,6 (1H,3H,5H)-PyriBidinetrione, 5-ethyl-5-phenyl- (9 CI)
50-06-6
C12-H12-N2-03
US 232.23, «p 1711-178 c
(CONTINUED)
TISSUE
7T28
Blood,
plasma
7129
Blood,
pi as B a
7130
Blood,
plasma
EXPOSURE ROUTE
Injection
Ingestion
ANALYTICAL
HETHOD
SC
GC
SC
NtWBEB
or CASES
a| 6
b) 6
a) 64
b) 31
2
BINGE
a) 11.5-20.0 ug/«l
b) 9.6-16.9 ug/Bl
a) 5. 1-28.0 ug/Bl
bl 9.5-35.5 ag/mi
a) Not applicable
b) Not applicable
c) Hot applicable
4( Hat applicable
«) Hot applicable
f) Dot applicable
HEAN
a) 16.2 tot- 3. 1
ug/nl
b) 13.8 «or- 2.5
ug/Bl
a) 11.1 »or- t.5
ug/Bl
b) 17.8 *or- 6.»
ug/Bl
a) 135 «g/l
b) 155 «g/l
c) 60 »g/l
d) 185 «q/l
e) 100 ig/1
£) 5« «g/l
GENERAL IHFOBBiTICH
a) Peak, 0.25-2.00 hr (Bean 0.92 +or-
0.60 hr) after 10 ag/kg phenobarbital
sodiun, in
b) Peak, 1.0-6.0 hr (Bean 5.83 +or-
2.3» hr) after 10 »gAg phenobarbital
acid, in
Peak tines significantly different
5-18 no old children «ith febrile
convulsions
ELOOD PltSHt; CEREBBOSPISAL 7LOID:
A»TICONVOLS»»IS; DRUGS; BYPKOTICS;
SEDATIVES; COnPABSTIVE ETAIOATIOHS
a) 2.71 *or- 1.81 «gAg/Jay
b) 2.51 +or- 1.20 ag/kg/day, plus
valproate sodium
a) and b) significantly different.
For both a) and bj ratio of level to
0.25-16.2 yr old epileptics
AGE; CHILDREN: BLOOD PLSSHA;
4HTICOSVOLSA1ITS; DSDG INTEBACTIOl! ;
DRDG THERAPI; DRUGS
. . _
heBOperfusioo
c) After 7 hr hemoperf usion
d) 18 yr old, initial aeasuresent
e) After 1.5 hr charcoal
hesoperf usion
Dose unknown
Unconscious, hypothertic.
hypotensive, hypoiic
UNITED KINGDOB; ADOLESCENTS; ADOLTS;
CASE HISTORIES; BLOOD PLASSA; DBOS
ABUSE; BHOSS; HIETOTICS; B OSCLE
RELAIANTS; TBEOPHYLLINES
REFERENCE
Hinagawa, K.
Biura, H.
Chiba, K.
Ishizaki, T.
1981
Pediatric Pharnacology
1:279-289
SuganuBa, T.
Ishizaki, T.
Chiba, !C.
Hori, «.
1981
99 (2) -.3 11-317
Vale, A.
Hellivell, ».
«iddop, B.
1982
Archives of Toxicology
00
(NEIT PAGE)
-------
Barbituric acid, 5-ethyl-5-phenyl- <8 CI)
2,U,6(lH,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl- (9 CI)
5C-06-6
C12-H12-N2-03
HR 232.23, HP 1711-178 C
(CO BUNDED)
TISSUE
Blood,
plasna
7132
Blood,
serum
7133
Blood,
serun
7131
cerebrosp
inal
fluid
EJPOSOBE BOOT!
Ingestion
Inqestion
Injection
Inqestion
Injection
ANALYTICAL
BETHOD
_ _
GC
Hit
GC
HOHBEB
OF CASES
21
1
a) 6
b) 6
BAHGE
b) 2-9 ug/ml
c) 18-40 ug/ml
e) 0.7-U.5 ug/ml
f ) 1. 5- 12 ug/ml
g) 3-10 ug/ml
h) 17-30 ug/ml
i| 2.3-7 ug/ml
j) 1.3-6 ug/ml
13.2-71.6 «g/l
11.9-18.9 ug/ml
a) 3.2-6.6 ug/al
b) 1.1-9.2 ug/ml
MEAN
b) Not give
c) Not give
e) Not give
f) Not give
g) Not give
h) Not give
i) Hot give
j) Not give
35. 9 ag/1
Median
Not applicable
a) 5.t +oc- 1.3 ug/ml
b) 6.0 + or- 1.6 ug/ml
GENERAL INFORMATION
mq 2x/day
b) Newborn of a) at delivery
treatment. 5 mg/kg within 2 hr of
birth, IH, and 50 »g/Jcg/day, oral.
thereafter
d) Newborn of a) , 20 days after
birth, treatment as in c)
e) Mothers as in a) , 3 days after
delivery
f) it mothers, at delivery, after 50
mg 2x/day
g) Newborn of f) at delivery
h) Hewborn of f) at end of 7 day
treatment, dose reginea as in c) ,
receiving phototherapy for elevated
serum bilirubin levels
i) Sew born of f ) , 20 days after
birth, dose regiaen as in c) , on
phot otherapy
1) Bothers as in f) , 3 days after
delivery
Esti nated from graph
Expectant Bothers and newborn
(gestational age 32-37 wk) receiving
phenobarbital to reduce risk of
hyper bilirubinemia
ADDLTS; NEWBORN; BLOOD PLASNA; DBDG
THERAPY; £>E DCS ; PREGNANCY
Dose 8-34 ng/kg (mean 23. ft *or- 7.1
mg/*;g) , rate 120 nq/hr until
predetermined clinical end-point.
Barbi tur ate addicts , 1 6-73 yr old.
estimated mean daily intake 1 g
(range 0.5-H g)
ADULTS; BLOOD SERUM ; ANTICONVDLSANTS;
DPOG ABDSE; DRUG THEKAPY; DRUGS
7 and 16 days after birth
Doses: 10 nq/kg, IV, on day 2 and
followed by 10 mg/12 hr, to day 7
(changed from IV to roal on day S) .
Phenytoin also administered.
Infant, wt 1,695 g, suffering
seizures 2nd day after birth and
treated with Dilantin and
phenobarbital
NEWBORN; BLOOD SEROM;
ASTICONVULSANTS; DROG THEBAPY; DRUGS
a) 1 hr after 10 »g/kg phenobarbital
sodium, IH. 36 1 of plassa level
b) 1 hr after 10 mg/kg phenobarbital
acid, IH. 50% of plasna level
peak plasma levels attained
5-18 mo old children with febrile
convulsions
Transient sedation in some
BLOOD PLASM*; CEBEB EOS PIKAL FLDID;
ANTICON70LS4STS; DRUGS; HYPNOTICS;
SEDATIVES; CCHPABATIVE EVALUATIONS
BEFEBENCE
Jailing, B.
Wallin, A.
Journal of Pediatrics
93 (D) 1695-6 98
Robinson, G.H.
Sellers, S.s.
Janecek, B.
1981
Clinical Pharmacology
and Therapeutics
30 (1) :71-76
Kiriyathian. S.
Kaojarern, S.
Rosenfeld, C.R.
1982
Journal of Pediatrics
100(1) : 1U6-149
Hinagawa, R.
niura, H.
Chiba, K.
Ishizaki, T.
Pediatric Pharmacology
1:279-289
(SBXT PAGE)
-------
Barbituric acia, S-ethyl-5-phenyl- (8 CI)
2,1,6(1H,3fl,5H>-Pyrimidinetrione, 5-ethyl-5-pheayl- (9 CI)
50-06-6
C12-B12-B2-03
»» 232.23, HP 174-178 C
(COKTIBOED)
TISSOE
7135
Urine
EXPOS ORE BOOTE
Inqestion
ANALYTICAL
BETHOD
Colorimetry
DOBBEB
OF CASES
BADGE
13-2 ug/ml
Dot given
GSDIEAL IDFOBflATIOB
3 hr and 7 days after 100 mg.
Initial measurement u ug/al at 1 hr.
Results corrected to a urine relative
density of 1.02500 ag/1
BEAM
0.3 ig/100 .1
Dot given
GEDEEAL IDPOEHATIOD
Drug induced fatality. Ethanol (0.16
g/100 •!) and phenobarbital (0.4
• g/100 Hi) also found.
Autopsy, 1975-76, Los Angeles County,
Ci
CALIFORNIA,; AUTOPSIES ; CASE
BISTOBIES; BLOOD; DRUG ABUSE; DBUGS ;
FOEESSIC HEBICIDE; ALCOHOLS
1-48 hr after 100 «g. Initial
•easureient 10 ug/1. 260 ug/1 at 72
hr.
Volunteer
URINE; DBUGS; HYPBOTICS; DABCOTICS;
nEASUREHEBT BETHODS
EEPERBSCE
Dakanura, G.B.
Doguchi, T.T.
Grieseaer, B.C.
1979
Journal of Analytical
Toxicology 3:137-U2
Usategui-GoBer , M.
Heveran, J. E.
Cleeland, R.
HcGhee, B.
Talischak, z.
Avdziej, T.
Grunberg, E.
1975
Clinical Chemistry
21 (10) : 1378-1382
.
U)
Ui
o
Bcnzeneethanaiine, alpha-»ethyl-D-propyl-, (»-)-
59366-97-1
C12-B19-D
B» 177.32
TISSOE
7138
Urine
EIFOSOBE ROUTE
Ingestioc
ANALYTICAL
HETHOD
GC
DDBBIB
OP CASES
2
BAHGE
a) lot given
b) Not given
HEAD
a) 13.4% of dose
b) 3.5% of dose
GEDEBAL INPORBATIOD
a) Betabolite,
l-d-hydroiypheoyl) -2- (u-propylaii.no)
propane
b) Setabolite,
1- (Q-hydroxy-3-«ethoxyphenyl)-2-n-pro
pylaiino) propane
2» hr output after 25 >g (base
equivalent) dose
Healthy 28 and 44 rr old
UBIRE; ADTOBOBIC DRUGS; DBOGS;
PSTCHOTSOPIC DROSS; BETABOLITES
BEFEREKCE
Coutts, B.T.
Davson, G. H.
1977
Research couuaications
in Chemical Pathology
and Pharmacology
17(21:349-352
-------
beta-D-Glucopyranosiduronic add, cyanophenylmethyl, (8)-
1332-94-1
C14-H15-N-07
III 309.27, HP 211-216 C
TISSUE
7139
Blood
71«0
Blood,
plasma
EXPOSURE FOOTE
Injection
Ingestion
ANALYTICAL
BETHOD
colorimetry
oc/as
» OH BEE
OF CISES
6
6
BANGE
a) 0.4-2.05 ug/ml
b) 1.01-2.01 ug/ml
a) Hot given
bi Not given
c) 2-27 ug/il
(NEXT
HEAH
a) Not given
b) Hot given
a) 1, 160 ug/ml
b) <1 ug/ml
c) Hot given
PAGE)
GENERAL INPORBATIOH
a) Range of CH peaks 1.5 - 2 he after
for 7 days, 6 subjects
b) CH peaks, days 4 and 5 after 0.5
g, oral, 3x/day plus 30 g almonds
with breakfasts, 1 subject. Peak
before almonds, 0.6 ug/ml
Amygdalin at doses and schedules used
had no significant side effects.
Adding almonds to diet increased
blood CN and caused nausea, vomiting,
headache, light-headedness, laden
sensations in extrenities. Syactoas
subsided after 1.5 hr. Malignancies
progressed at periods of 5 to 15
weeks after starting treatment.
CiRCIHOIUS; SJHCOBAS; BLOOD; BIOOO
PLASHA; URIBE; DRUG IHTER1CTIOH ; DRDG
TBEFAPY: DSOGS; CIA HIDE;
TBIOCYAHATES; DIETS; HETABOLITES
a) Peak, unchanged drug after 4.5
g/sq »/day, IV, for 21 days
b) Peak, unchanged drag 30-60 min
after first dose of 0. 5 g, oral
c) llean peak levels thiocyanate 2 h
after 0.5 g, oral, a.n., day 1 and
day 14. Total dose 0. 5 g 3l/day
Host IV dose excreted unchanged in
urine
Increased blood cyanide after oral
dose
Terminal cancer patients, Ht 47-86 kg
had no significant side effects.
blood cyanide, and caused nausea,
vomiting, headache, light-headedness,
laden sensations in extremities.
Symptoms subsided after 1. 5 hr.
naligcancies progressed at periods of
5 to 15 veeks after starting
treatment.
CARCIHOHAS; SiBCOBAS; BLOOD; BLOOD
PLASHA; ORIHE; DRUG INTERACTION; DRUG
TSERIPY; DRUGS; CriKIDZ;
TBIOCIAHATES; DIETS; BETABOIITES
REEEREHCE
Koertel, C.G.
Ames, B.B.
Kovach, J.S.
Boyer, T.P.
Rubin, J.R.
Tinier, J.H.
1981
Bedical Association
245(6) : 591- 594
Hoertel, c.G.
Ames, B.g.
Rovach, J.S.
Boyer, T.P.
Rubin, J.E.
Tinker, J.H.
1981
Journal of the American
Bedical Association
245(6) :591-594
OJ
Ln
-------
beta-D-Glucopyranosiduronic acid, cyanophenylaethyl, (R) -
1332-94-1
C14-H15-N-07
US 309.27, DP 211-216 c
(CONTINUED)
TISSUE
Urine
EXPOSURE ROUTE
Injection
logestion
ANALYTICAL
BETHOD
BDBBER
OF CASES
BAHGE
b) 8-32X
a) Not given
b) Hot given
GENERAL INFORBATIOH
a) 4.5 g/sg (/day. IV, 21 days
b) 0.5 g 3x/day, oral, 7 days
* of dose
nean 24 h excretion
Terminal cancer patients, wt 47-66 kg
Anvgdalin at doses and schedules used
had no significant side effects.
Adding alnonds to diet increased
blood CN and caused nausea, vomiting,
headache, light-headedness, laden
sensations in extremities, symptoms
subsided after 1.5 hr. Malignancies
progressed at periods of 5 to 15
weeks after starting treatment.
CAPCINOBAS; SARCOBAS; BLOOD; BLOOD
PLISBM URINE; BEOG INTERACTION; DRBS
THERAPY; DRUGS; CYANIDE;
THIOCYAHATES; DIETS; HETABOLITES
Hoertel, C.6.
Ales, U.K.
Kovach, J.S.
floyer, T.P.
Rubin, J.R.
Tinker, J.H.
1981
Journal of the American
Medical Association
215(6) : 591-59«
Biguanide, 1,1-dimethyl- (6 CI)
Imidodicarbonimidic diamide, N,N-dimethyl- (9 CI)
657-2»-9
C4-HI1-B5
B» 129.17
I TISSUE
1
71H2
Blood,
plasma
71«3
Urine
EXPOSURE BOOTE
Injection
Ingestlon
Injection
Ingestion
I ANALYTICAL
I BETHOD
OC-EC
OC-EC
. .
BOBBER
OF CASES
16
16
RANGE
a) 9-0.02 ug/ml
b) 1.30-0.59 ug/ml
c) 4.03-1.81 ug/ml
d) «. 20- 1.89 ug/ml
e) 6. 10-1. 79 ug/ml
f) Hot given
a) Hot given
b) 31.6%-59.5«
c) 28.8X-13.3X
d) 26.6X-48.2X
e) 18.1X-39.5X
1
BEAN
a) Not given
b) 1.02 tor- 0.34
ug/ml
c) 3, 10 tor- 0.93
ug/ml
d) 3.25 tor- 0.97
ug/ml
e) 3.24 tor- 1.46
ug/ml
f) 2.5 ug/ml
a) 79X tor- 2X
b) 49. 6X tor- 12.5*
c) 37.9% tor- 6.6X
d) 38. IX tor- 8.9X
e) 34. 7X tor- 7. OX
GENERAL IHFORBATION
a) 0 and 12 hr after 0.25 g IV (»
subjects)
t) nean peaks, 2.2 hr after 0.5 g
oral (0 subjects)
c) Bean peaks, 1.5 hr after 1.5 g
oral (U subjects)
d) Bean peaks, 2.1 hr after 1.0 g
oral (4 diabetics)
e) nean peaks, 2.4 hr after 1.0 g
oral (8 diabetics, 4 taking
chlorpropramide)
f) Peak level, after 0.5 g 2x/day for
12 days (4 diabetics)
a) and f) estimated from graph
46-81 yr old maturity onset diabetics
and healthy 30-36 yr olds
ADULTS; DIABETES; BLOOD PLASBA;
OBINE; DRUG THERAPY; DRUGS;
BIOACCUBUIATIOS
a) 0.25 g IV (4 subjects)
b) 0.5 9 oral (4 subjects)
c) 1.5 g oral (4 subjects)
d) 1.0 g oral (4 diabetics)
e) 1.0 g oral (8 diabetics, 4 taking
chlorpropramide)
V unchanged drug recovered within 72
hr
a) estimated from graph
46-81 yr old maturity onset diabetics
and healthy 30-36 yr olds
JDOITS; DIABETES: BLOOD PLiSHA;
URINE; DRUG THERAPI ; DRUGS;
BIOACCUHULATI08
REFERENCE
Tucker, G.T.
Casey, c.
Phillips, P.J.
Connor, H.
Ward, J.D.
Hoods, K.F.
1981
British Journal of
Clinical Pharmacology
12:235-246
Tucker, G.T.
Casey, c.
Phillips. P.J.
Connor, H.
ward, J.D.
Hoods, H.F.
1981
British Journal of
Clinical Pharmacology
12:235-246
-------
Eismuth
70110-69-9
Ei
AtB 208.98, HP 271.5 C, BP 1579 C
7144
Blood
7145
Urine
EXPOSUEE ROUTE
Ingestion
Ingestion
ANALYTICAL
BETHOD
.
AAS
.
AAS
HDBBEE
OF CASES
52
32
BADGE
a) 1.0-1.2 ug/ml
b) 0.9-2.6 ug/1
c) 2.5-8.0 ug/1
d) 2.0-35.0 ug/1
a) 240-704 ug/24 hr
b) 400-1350 ug/24 hr
c) 118-1330 ug/24 hr
d) 85-1052 ug/24 hr
e) 76-997 ug/24 hr
f) 82-684 ug/24 hr
BEAN
a) 1.0 ug/1
b) 1.7 +or- 0.7 ug/1
c) 4.2 *or- 2.0 ug/1
d) Not given
a) 410 «or- 134 ug/24
hr
b) 926 *or- 267 ug/24
hr
c) Not given
d) Mot given
e) Not given
f) Not given
Eromide
21959-67-9
Er
B« 79.90, BP -7.2 C, BP 58.78 C
GENEEAL IHFORBATION
a) 3 of 20 healthy blood donors
b) Day 5 after 10 ml (18 mg Bi/il)
OX/day (8 subjects)
c) Day 10. Same as b) followed by 20
ml Hi/day for 5 days (8 subjects)
d) Last day after 5 •! «/day for 1-6
¥k (24 ulcer patients)
G»STBOINTESTIN4L DISEASES; BLOOD;
DEINE; DB0G THES1PY; DRUGS; BISMUTH;
BETSLS
a) Day '- after 10 il (18 mg Bi/il)
4I/day (8 subjects)
b) Day 10. Same as a) followed by 20
nl 41/day for 5 days (8 subjects)
c) Last day after 5 il 4X/day for 4-6
vk (24 ulcer patients)
d) 5 days posttreatment (saae as c)
e) 10 days posttreataent (sane as c)
f) 15 days posttreataent (sale as c)
As tripotassiam dicitrato-bisauthate
21-68 yr olds
GASTROINTESTINAL DISEASES; BLOOD;
OBIBE; DBUG THEHACT; DBOSS; BISBOTH;
BETALS
Lee. S.P.
1981
Research Communications
in Che meal Pathology
and Pharmacology
34(2):359-364
Lee, S.P.
1981
Research Communications
in Chemical Pathology
and Pharmacology
34 (2): 359-364
OJ
Ln
TISSUE
7146
Blood,
serum
.....
EXPOSURE HODTE
ANALYTICAL
HETHOD
nan BEE
OF CASES
GAUGE
a) 0-49 mg/dl
b) 50-99 »g/dl
c) 100-199 mg/dl
d) >200 mg/dl
HEAN
a) Not applicable
b) Hot applicable
c) Not applicable
d) Not applicable
GENERAL I»FORHATIO»
a) »8. 4-49.2S of patients
b) 20.3-22. 4»
c) 22. 5-25. 0*
d) 5. 9-6.3J
Data expressed as NaBr
Levels in patients admitted to
psychiatric hospitals
Australia
AUSTRALIA; ADULTS; BLOOD SE8US; DRUG
ABOSE; DRUGS
REFEEEKCE
Andrews, S.
Francis, I.
Oey, B.G.
1974
Medical Journal of
Australia 1 (1) :18-19
-------
Eutjrophenone, 4- (4- (p-chloropbenyl) -4-hydroxypiperidino) -4'-fluoro- (8 CI)
1-Butanone, 1- (»- (»-chlorophenrl)-4-hydrojy-l-piperidinyl|- 1- (4-fluorophenyl) - (9 CI)
52-86-8
C21-B23-C1-F-N-02
8« 375.88, HP 118-119.11 C
TISSUE
71117
Blood,
plasna
7K8
Blood,
serum
7149
Saliva
EIPOSUEE ROUTE
luges tion
Ingestion
ANALYTICAL
HETHOD
RIA
BIl
811
NUHBEB
OF CASES
a) 1
b) 1
c) 1
4) 1
98
98
EANGE
a) 16. 2-23. K ng/ll
b) 21.9-27.6 ng/ml
c) 80.3-162.8 ng/»l
d) 104.9-181.6 ng/«l
a) 8-30 nq/*I
b) 13-100 ng/ll
c| 25-65 ng/»l
a) 2-32 ng/.l
b) 4-140 ng/il
c) 35-160 ng/«l
BEAH
a) Hot given
b) Hot given
c) Hot given
d) Not given
3) Hot given
b) Hot given
c) Hot given
a) Not given
b) Not given
c) Not given
GENERAL IS FORMATION
a) 10 «g/day
b| 20 «g/day
c) 60 »g/day
d) 60 ag/day
Bange of weekly aeans. Tceated 3 «k.
Absence of coffee and tea during nk 2
did not increase bioavailability.
dentally retarded patients with
psychotic disturbances.
NEB ZEALAND; ADDLTS ; BEHAVIOB
DISOBDEPS; BENTAL RETARDATION; BLOOD
PLASHA; PSYCBOTBOPIC DBDGS ;
COBP1BATIVE EVALOSIIOHS; DIETS:
DBDGS; CAFFEINE
a) 10-100 ug/kg/day
b) >100-200 ag/kg/day
c) >200-300 ug/kg/day
Positive correlation with salivary
levels
18-5tt yr old schizophrenics, Japan
JAPAN: CENTRAL NERVOUS SISIEH
DISEASES; NERVOUS SISTEB DISEASES;
BLOOD SFROn; SALIVA; DEDS TRERAPI;
DBDGS; PSICBOTBOPIC OR05S;
BEASOBEnENT BETHODS
a) 10-100 ug/kg/day
b) >100-200 ug/kg/day
c) >200-300 ngAg/iay
Bange estimated fron graph
Positive correlation with sera*
levels
18-54 yr old schizophrenics, Japan
JAPAN: CENTRAL NERVOUS ST51EB
DISEASES; NBEVOUS STSTEB DISBASES;
BLOOD SEROS; SALITA; DSBS THBBAPr;
DBDGS; PSICBOTBOPIC DRUGS;
HEASDBEHENT BETHODS
REFERENCE
&owen, S*
Taylor, K.B.
Glbb, I. A. HcL.
1981
Lancet
1(8231) -.1217-1218
Tanazaai, S.
Biura, S.
1981
Pharnacopsychiatry
16:1711-183
Taaazuni, S.
fliura, S.
1981
International
Phariacopsychiatry
16:174-183
Co
Ui
caffeine (8 CI)
1B-Purine-2,6-dlone. 3,7-dihydro-1,3,7-tri«ethyl- (9 CI)
58-08-2
C8-B10-N4-02
HR 1911.19, BF 238 C
TISSUE
7150
Blood,
plasia
EXPOSURE BOOTE
Ingestion
ANALYTICAL
BETBOD
TLC
6C
HUB, BIB
OF CASES
a) 1
b) 1
-
BADGE
a) 1800-500 ng/Ml
b) 1700-1300 ag/«l
BEiS
a) Hot applicable
b) Not applicable
GE»EBAl XSrOBBATIOS
-
a) 0.5 and 12 hr
b) 1 and 12 hr
Estimated from graph
Dose 64 mg pins 454 «g salicylic acid
324 ig phenacetin, and 60 ig codeine
phosphate
30 and 32 yr old nursing (others
ADULTS; BLOOD PLASBA; BILK;
ANALGESICS; DBUGS; NARCOTICS;
CAFTEINE; LACTATIOH
BWBHENCE
F India y, J.8.S.
DeAngelis« R. L.
Kearney, N. F.
Welch, B.9.
Findlay, J.fl.
1981
Clinical Pharnacology
and Therapeutics
29(51:625-633
1
(HBIT PAGE)
-------
Caffeine (8 CI)
1H-Purine-2,6-aione. 3,7-dihydro-l,3,7-tti»ethil- (9 CI)
56-08-2
C8-H10-H4-02
HV 194.19, Xf 238 C
(COHTIHOED)
TISSUE
7151
Blood,
plasma
7152
Bilk
EIPOSOBE BOOTS
Ingestion
Ingestion
AHAiyTICAL
BETBOD
HPLC
TLC
GC
son BEE
OF CASES
16
a| 1
b) 1
BINGE
2.80-2.37 ug/sl
a) 1300-400 eg/Hi
b) 1600-200 ng/«l
BEAM
Hot given
a) Hot applicable
b) Hot applicable
GESEEHL INFOBBJTIOII
2 and 4 he after 250 >g. Initial
Beasurement 2.66 ug/Bl at 1 hr
Increase in plasna free fatty acid
levels and urinary catecholaBines,
but no change in plasaa binding of
chlordiazepoxide, diazepaft, or
propranolol.
BICOD PtASNA; DBOG ISTEBACTIOB;
DBDGSJ FATS; CAFFEISE
a) 1.5 and 12 hr. Initial
•easureaent 600 ng/Bl at 0.5 hr
t) 3 and 48 hr. Initial Measurement
1000 ng/»l at 0.5 hr
Estimated froB gcaph
Dose 64 ag, plus 321 Bg phenacetin.
45Q ig aspirin and 60 ig codeine
phosphate
30 and 32 yr old nursing Bothers
•DOLTS; BLOOD PLASBA: BILK;
JHALGESICSj DBOGS; HiBCOTICS;
CAtPEIKE; 1AC1ATIOH
BEFERENCE
Patwardhan, B. V.
DesBond, P. V.
Johnson, B.F.
Dunn, G.D.
Bobectson, D.H.
HoyuBpa, A. H.
Schenker, s.
1980
Clinical Phacaacology
and Therapeutics
28(31:398-403
Findlay, J.B.J.
DeAngelis, B. L.
Kearney, n.F.
Helen, U.K.
Findlay, J. n.
1981
Clinical pharmacology
and Therapeutics
29 (5): 625-633
calciui
7440-70-2
Ca
AtH 40.08, HP 850 C, BP 1»»0 C. »P 10
Sg at 983 C
U>
Ul
Ul
TISSUE
7153
Blood,
plasBa
EXJOSOBE BODTE
Ingestion
AHALTTICAL
BETHOD
>AS
NH8BEB
OF CASES
a) 10
b) 20
cl 20
BINGE
a) 9.3-9.7 ng/100 al
b) 9.2-9.9 nig/100 al
c) 9.2-9.8 ag/100 nl
MEAN
a) 9.5 «g/100 •!
b) 9.5 » g/1 00 nl
c) 9.6 ag/100 mi
.
GENERiL ISTFOEnATIOH
a) Controls, no n- nutrient supplement
plus lactose-containing placebo
t) High protein-vitanin liquid
supplement plus Mineral capsule (100
ng Ca (CaCO3)r 6 days/wk
c) Supplement and mineral capsule as
in b) plus i*0 mg Zn as cartonate, 6
Eange of means over 20 mo
No supplements daring 4 mo summer
vacation
Significantly increased ht, vtr and
bone ages in boys receiving Zn during
final 12 mo of supplementation.
despite subnormal Zn levels in plasma
throughout study
Ca levels maintained within normal
limits vith a few exceptions
13 yc old prepubertal village
schoolboys, southern Iran
IBM); ADOLESCENTS; HUTBITIOHAL
CfFICIENCIES; BLOOD PtASHA; BLOOD
SEfiOM; EBYTBPOCTTES ; CALCIOH; I SON ;
IHOSPHOEOS; ZINC; DIETS
EEPEB2HCE
Konaghy, H. A.
Reinhold, J.S.
Mahloudji, H.
Ghavami, p.
Spivey Pox, H. R.
Halsted, J. A.
197U
Clinical Nutrition
27(2) :112-121
(NEXT PAGE)
-------
Calcium
7440-70-2
Ca
AtS 10.08, HP 850 C, BP I1DO c, VP 10
Sq at 983 C
(CONTINUED)
TISSUE
7154
Blood,
serum
7155
Blood,
serum
7156
Orine
EXPOSURE BODTE
-
Injection
Rectal
Ingestion
ANALYTICAL
METHOD
Chem
.
US
NOBBER
OF CASES
100
1
8
RANGE
a) Mot given
b) Hot g iven
c) Hot given
d) Hot given
a) Hot applicable
b) Hot applicable
c) Hot applicable
d) Mot applicable
e) Not applicable
f) Not applicable
..
a) Hot given
b) Hot given
c) Hot given
d) Not given
e) Hot given
f| Hot given
h) Hot given
HEAH
a) 9.06 +or- 0.84
ag/100 ml
b) 9.03 tor- O.flO
mg/100 «1
c) 9.61 *or- 0.76
d) 9.90 +oc- 0.72
mg/100 ml
a) 9.2 mg/100 ml
b) 5.8 mg/100 il
c) 8. 1 mg/100 ml
d) 8.8 mg/100 ml
e) 8.9 mg/100 ml
£) 9.6 mg/100 ml
a) 100 +or- 28 ng/day
b) 68 *or- 19 mg/day
c) 198 +or- 71 mg/day
d) 149 »or- 14 mg/day
e) 66 +or- 16 mg/day
f) 43 *or- 12 mg/day
h) 58 »or- 6 mg/day
GENERAL IN?OBBATIOS
a) 75 women lactating 2 BO or more
b) 25 women from a)
c) Homen in b) , 1 mo after
supplementation with 500 ng Ca and
1,600 Id (40 ug) vitamin D daily
supplement
22-34 yr olds. North India
Serum chemistry suggested
osteomalacia, but radiographs of
no abnormalities.
OSTEOHALACIA; DIETS; LACTATIOK;
PREGNANCY; CALCIOH; PHOSPBOBUS;
IHDIA; BOSS DISEASES; HBTBITIONAL
DEFICIEHCIES; NUIBITIOHAL DISOHDEBS;
BLOOD SEBOH
a) 13 mo before admission
b) At admission, 12 hr after fleet
emema (238 mEq phosphate)
c) Day 2, after 180 mg Ca gluconate.
81 mg Ca chloride, KO mEg HaHC03, all
IV
d) Day 3, additional 90 mg Ca and 40
»Ig HaHCOS
3) Day 4
f) Day 7
4.5 yr old uitK chronic renal failure
Carpopedal spasm, hyperventilation.
diarrhea, tachycardia
CBIIDRED; KIDHEr. DISEASES; BLOOD
SEROH; CALCIUB; PHOSPBOBDS
a) 226 mg/day
b) 214 mg/day
c) 2236 mg/day
d) 2307 mg/day
e) 228 mg/day
f) 225 mg/day
h) 2358 mg/day
ILLIKOIS; 08IHE; CALCItja; FLOORIDE;
PHOSPHORUS; HETABOLISB
_
BEFEREHCE
^arya, R.K.
Bathee, S.
Arora, S.R.
1981
Annals of Nutritional
Hetabolism 25.56 64
Oxnard, S.C.
O'Bell, J.
Stupe, H.E.
1974
Pediatrics
53(1) :105-106
Spencer, H.
Osis, D.
Kramer, L.
wiatrovski, E.
Harris, c.
1975
105:733-740
CO
-------
Chloral hydrate (8 CI)
1,1-Ethanediol, 2,2,2-trichloro- (9 CI)
302-17-0
C2-H3-C13-02
BS 165.42, HP 57 C (also reported as 52 C), BP 98 C
TISSOE
7157
Blood
EXPOSURE EOOTE
ANALYTICAL
BETBOD
RUBBER
OF CASES
3
BASSE
0.01-1.9 lg/100 ll
BEAD
Not given
GENERAL INFOSHATION
Drug induced fatalities.
A«itriptyline (2 cases, 0.02-0.03
no/100 ml), ethanol (1 case, 0. lit
g/100 ml) , pentobarbital (1 case,
0.10 ig/100 ml), and codeine (1 case,
0.05 mg/100 nl) also found
Measured as trichloroethancl
Autopsies, 1975-76, Los Angeles
County, CA
CA1IFOENIA; AUTOPSIES; CASE
HISTORIES: BLOOD; DRUG ABOSB; DRUGS;
FCSEHSIC BEDICINE; ALCOHOLS
REFERENCE
Nakamura, G.R.
Griesener, B.C.
1979
Journal of Analytical
Toxicology 3:137-142
Chloranphenicol-3-Bonosuccinate (No postings in CHEMLINE) .
TISSOE
7158
Elood,
serun
7159
Orine
Clcdrcnate d
TISSDE
7160
Blood,
plasma
EXPOSURE EOOTE
Injection
Injection
sodium (Ho posti
EXPOSURE EODTE
Injection
ANALYTICAL
SBTBOD
BPLC
BPLC
NOHBER
OP CASES
<*5
15
EANGE
a) 0-40 ug/ml
b) 5-47 ug/ml
a) 6-80X
b) 3-60 %
c) 2-42*
BEAN
a) Hot given
b) Not given
a) 33 »or- 5. 3%
b) 18 tor- 3X
c) 14 tor- 2%
S.E.
GENERAL INFORBATION
b) Chloraraphenicoi
Peak levels during first 3 hr after
initiation of therapy. Dose 15-200
mg/kg/21 hr IV
Estinated from graph
Hospitalized infants and children,
age 3 days-16 yr, being treated for
infections
CHILDREN; INFANTS; INFECTIONS; BLOOD
SERtJH; ORIHE; ANTIBIOTICS; DROG
THEEAPT; DEOGS
a) Chloranphenicol succinate
b) Chloramphenicci glucuronide
c) Chloranphenicol
? of dose
Dose, 15-200 mg/kg/24 hr IV as
succinate
CHILDREN; IHFANTS: INFECTIONS; BLOOD
SEEUH; BRINE; ANTIBIOTICS; DROG
THERAPY; DRUGS
REFERENCE
Kauffaan, R.E.
Hiceli, J.N.
Strebel, I.
Buckley, J.A.
Done, A.K.
Dajani, A.s.
1981
Journal of Pediatrics
98(2) :315-320
Kauffnan, R.E.
Biceli, J.N.
Strebel, L.
Buckley, J.A.
Done, A.K.
Dajani, A.S.
1981
Journal of Pediatrics
98(21:315-320
gs in CHEBLISE).
ANALYTICAL
BETHOD
CC
NUBBEB
OP CASES
e
iABGE
a) 13-2.3 ug/ml
b) 20-2. 1 ug/ml
c) 40-3. 2 ug/ml
BEAK
a) Not given
b) Not given
c) Not given
GENERAL INFORBATION
a) 1 and 4 hr after 3 igAg (lean ADC
29.8 ug/al hr)
b) 1 and 6 hr after 6 »g/kg (lean AUC
58.3 ug/Bl hr)
c) 1 and 6 hr after 10 ng/kg («ean
AOC 102.7 ug/ml hr|
Healthy 23-30 yr olds
ADUITS; BLOOD PLASH A; URINE; DRUGS
1
REFERENCE
Conrad, K.A.
Lee, S.fl.
1981
Clinical Pharmacology
and Therapeutics
30(1) :114-120
(NEXT PAGE)
-------
Clodronate aisodiuft (So postings in CHESLIHEJ .
(COHTINUED)
Tissor
7161
Orine
EXPOSURE ROUTE
Injection
ANALYTICAL
METHOD
CC
HUB BEE
OF CASES
6
BADGE
Not given
BEAN
76.2 tor- 8.7*
GENERAL ISFOEHATIOS
48 he cuaulative output of unchanged
drug. No difference between 3, 6 and
1C mg/kg doses
Healthy 23-30 yr olds
ADULTS; BIOOD PLAS9A; OBIHEj DP06S
BBFEBENCE
Conrad, K.A.
lee, s.n.
1981
Clinical Pharmacology
and Therapeutics
30(1): 1 11-120
ccpper
74UO-50-8
Cu
AtB 63.516, HP 1083 C, BP 2595 C, YP 1 •• Hg at 1628 C. 10 IB flg at 1870 C
TISSDE
7162
Blood,
EXPOSURE BODTE
Injection
ANALYTICAL
BBTBOB
AAS
HUHEEB
OF CASES
a) 23
b) 22
BAHGE
a) 21-16.5 u»ol/l
b| 22-18 u«ol/l
BEAH
a) liot given
b) Not given
GENERAL IKFOTBATIOS
a ) P reope ra ti ve and po stop ecat i ve day
2. 18. 5 u«ol/l on day 5
Pceoperative level 19 mo 1/1. 20 nq
Zn and 1.2 mg cu iv daily
Range of means, est imated fco» graph
Surgery patients
ACOLTS; BtOOD SEPUM; COPPER; HETALS;
ZINC
REPEREHCE
HallbooV, T.
Hedelin, H.
flcta Chirurgica
Scandinavica
14«: «23-«26
Cotinine (8 CI)
2-Pyrrolidinone, 1-«et hyl-5-(3-pyridinyl-, (S) - (9 CI)
U86-56-6
C10-H12-B2-0
BW 176.21, 210-211 C at 6 ill Hg
OJ
Ol
00
TISSUE | EXPOSURE ROOTE
1163
f-lasva
Inhalation
Oral
absorption
ASAITTICAL
flETHOD
GC
NUNBEB
OF CASKS
161
EANGE
a) 12-576.1 n»ol/l
b) 13.1-3857.0 n»ol/l
c) 82.1-3421.0 n«ol/l
d) 29.1-5319.0 niol/1
e) 135.7-4310.1 n«ol/l
«EAH
a) 202. 8 naol/1
b) 1200.6 a»ol/l
c) 1757.8 n»ol/l
d) 2560.2 n«ol/l
e) 1913.3 »or- 834.7
nnol/1
GENERAL INFORMATION
a) 3 subjects, never used snuff.
range 8.6-667.0 nnol/1 before
snuffing
t) 10 occasional snuffers, range
11.8-3941.0 nmol/1 before snuffing
c) 8 daily snuffers, range
d) t) multiple dose snuffers, range
5.1-5227.0 before snuffing
e) 136 heavy cigarette smokers 2 sin
after finishing cigarette
25 snuff users at seating in
Wellington , Soaerset, United Kingdom
136 heavy cigarette snokers at
saokers ' clinic. Bauds ley Hospital
UNITED KINGDOM; ADULTS; BLOOD PLASHA;
NICOTINE; HETABOLISa; BETABOLITES;
SMOKING; TOBACCOS
PEPEEBNCE
Bussell, H. A.H .
Jarvis, a.J.
Devitt, G.
Feyerabend, C.
1981
British Medical Journal
/
i
-------
Counarin, 3-(alpha-acetonylbenzyl)-1-hydrozy- (8 CI)
2H-1-Benzopyran-2-one, S-hydroxy-3-(3-oxo-1-phenylbatyl) - (9 CI)
81-81-2
C19-H16-0"4
KB 308.32, (IB 161 C
TISS0E
Blood,
plasna
EXPOSOBE BOOTE
ANALYTICAL
HETHOD
US
1-Propanamine, 3-dibenz (b, e) ore pin- 11 (6H) -ylidene
1668-19-5
C19-H21-H-0
BW 279.37, BP 151-157 C at 0.03 >i Hg, 260-270 C
TISSUE
7165
Blood
EIPOSDBE B001E
ANALYTICAL
METHOD
HOBBEB
OF CASES
6
BADGE
b) 5.53-0.02 ug/ol
c) 6.02-0.08 ug/nl
d) 5.73-0.03 ug/»l
e) 11.57-0.17 uq/Bl
f) 11.26-0.05 ug/al
HEA8
b) Not given
c) Mot given
d) Sot given
e) Not given
f) Sot given
GENERAL INFORMATION
ug/nl at 1 hr
b) Saae as a). Dose plus
secobarbital. 1 .86 ug/il at 1 hr
c) C13-5(-) warfarin level. 2.56
ug/nl at 1 hr
d) Saae as c) . Dose plus
secobarbital. 1.90 ug/nl at 1 hr
e) C12/C13-K, S (+ and -) warfarin.
5.61 tig/Bl at 1 hr
f ) Saae as ej . Dose plus
secobarbital. 3.76 ug/»l at 1 hr
Dcse 1. 5 ng/kg warfarin
p sue dor ace nate. Secobarbital 100
ng/day for 7 days before and 5-9 days
after warfarin
Pange of means at 4 and 210 hr after
dose
Healthy 18-30 yr olds
Secobarbital reduced
hypoprothrombinenia of the
pseudoracenic warfarin
BLOOD PLASHA; ANTICOAGULANTS; DRUG
INTERACTION; DPOGS
REFERENCE
Trager, W.F .
Motley, C.H.
Howald, fl.
1980
Clinical Pharmacology
and Therapeutics
28(2): 187-195
s,»-di»ethyl- (9 CI)
t 0.2 u> Hg
NUBBEB
OF CASES
2
BANGE
. _
0.10-0. 16 ng/100 Bl
ME5N
Not given
GENERAL INFORMATION
Crug induced fatalities. Ethanol (1
case, 0.19 g/100 ml) and propoxyphene
(1 case, 0.03 ng/100 nl) also found.
Autopsies, 1975-76, Los Angeles
County, CA
CALIFORNIA; AUTOPSIES; CASE
HISTORIES; BLOOD; DRUG ABUSE; DRUGS;
POPESSIC MEDICINE; ALCOHOLS
REFERENCE
Nakanmra, G.8.
Noguchi. T.T.
Griesener , E. C .
1979
Journal of Analytical
Toxicology 3: 137-112
-------
Diflunisal (So postings in CHEBLINE).
C13-H8-F2-03
fl« 250.20, HP 210-211 C
TISSUE
7166
Blood,
plasma
'7167
urine
EXtOSOEE BOOTE
Ingestion
Ingestion
ANALYTICAL
HETHOD
Fluorometry
Fluorometry
NUMBER
OF C1SES
12
BADGE
a) Not given
b) Wot given
c) Not given
d) Not given
e) Not given
f) Not given
.
b) Not given
c) Not given
d) Sot given
e) Not given
f) Not given
BEAN
a) 36.0 tor- 5.8
ug/ml
b) 30.1 tor- 5.6
ug/ml
c) 19.5 tor- 6.2
ug/ml
d) 29.7 tor- 6.5
ug/ml
e) 38.7 tor- 7.5
ug/ml
f) 31.6 tor- 7.5
ug/ml
b) 173 tor- 23 mg
c) 155 tor- 30 mg
d) 18» tor- 21 mg
e) 180 tor- 37 mg
f) 179 tor- 27 mg
GEBEBAL IKFOBHATION
a) 2.12 tor- 0.88 hr, fasted control.
no antacid
b) 3.10 tor- 1.17 hr, postprandial.
no antacifl
c) 2.99 tor- 1.33 hr, fasted, 15 ml
A1(OH)3 gel
d) 3.58 tor- 1.56 hr, postprandial.
15 ml A1(OH)3 gel
Mg(OH)2 suspension
f) 3.28 tor- 1.68 hr, postprandial.
15 ml Al(OH)3/Hg(OH)2 mixture
nean time to peak level after 250 mg
diflunisal given just after antacids
A1(OH)3 gel reduced peak level «6*
Hg(OH)2 suspension (fasting)
increased early levels (1301 at 0.5
hr and 6«* at 1 hr)
Bean age 23 yr, mean tft 72 kg.
healthy subjects
ASTACIDS; ADULTS; BLOOD PL ASH A;
UBIBE; ANALGESICS; ANTI-INFLAHBATOBY
AGSNTS; DfiOS INTBBACTION; DRUGS;
AIOSIDDII; BUGBESIOH
b) Postprandial, no antacia
c) Fasted, 15 ml 11 (OH) 3 gel
d) Postprandial, 15 ml Al (OH) 3 gel
e) Fasted, 10 ml Bg(OH)2 suspension
Al(OH) 3/Bg(OH)2 suspension
Hean 96 hr recovery after 250 »g
diflunisal given just after antacids
en urinary recovery
A1(OH)3 gel reduced mean 96 hr
excretion 1»*
Bean age 23 yr, mean vt 72 kg.
healthy subjects
ANTACIDS; ADULTS; BLOOD PLASBA;
UEINE; ANALGESICS; AHTI-IHFLAHBATORY
AGEHTS; DEUG INTEBACTIOH ; DRUGS;
1
EEFEEENCE
Tcbert, J.A.
Deschepper, P.
Tjandramaga, T.B.
Hullie, A.
Butinx, A. P.
Heisinger, H. A. p.
Huber, P.B.
Hall, T.L.P.
1981
Clinical Pharmacology
and Therapeutics
30(3) :385-389
Deschepper, P.
Tjandramaga, T.B.
Bullie. A.
Butinx, A. P.
Huber, P.B.
Hall, T.L.P.
Teh, K.c.
1 981
Clinical Pharmacology
and Therapeutics
30(3):385-389
Co
ON
O
-------
Eigoxin (8 CI)
Card-20(22) -enolide, 3- ((0-2,6-diaeoxy-beta-D-ribo-hexopvranosyl- (l-
-------
tigoxin (8 CD
Card-20 (22) -enolide , 3- ((0-2,6-dideoxy-beta-D-ribo-hexopyranosyl- (l-4)-o-2,6-dideoxy-beta-D-nfao-hexopyranosyl- (1-4 ) -2,6-dideoxy-beta-D-ribo-hexopyranosylJoxy) -12, 11-aihydroxy-,
(3beta,5beta,12beta)- (9 CI)
20830-75-5
C"41-B6«-01»
B» 780.92, HP about 265 C (decomp)
(COHTISUED)
TISSUE
7172
Orine
EXPOSURE ROUTE
Infection
ANALYTICAL
BETHOD
NOBBEB
OF CASES
a) 5
b| 1
c) 1
BASGE
a) 5.0-21.1*
b) dot applicable
c| Nat applicable
HE AN
a) 11.1 »or- 6.7S
b| 3.1*
c) 3. 9*
GEHEBAL IHPORBATION
a) 21 hr after 0.02 ug/kg
b) 8 hr after 0.02 «g/kg
c) 12 hr after 0.02 »g/kg
f of dose
Bean renal digoxin clearance 10. tt
26-36 wk («ean 29.9 vk) , postnatal
age 1-9 days (Dean 1.1 days), wt
820-2710 g (mean 1160 g)
Therapy for left ventricular volune
overload secondary to patent ductus
arteriosus
HEBBORN; BtOOD SESOB; OBIHI;
AHTiaRRHYTHfllC 4GENTS; DIORETICS;
CEOG THEEUPY; DRUGS
REFERENCE
Kg, P.K.
Cote, J.
Schiff, 0.
Collins-Sakai, R.L.
1981
in Cbeoical Pathology
3t (2) :207-216
E«€tine (8 CI)
Eietan, 6',7*,10,11-tetra«ethoiy- (9 CI)
H83-18-1
C29-BIIO-N2-01
US H80.63, (IP 74 C
7173
Bile
717)1
Blood
EKPOStJBE EOD1E
Ingestion
Ingestion
1
iHAlYTICAL
BETHOD
TLC
TIC
NDBBEB
OF C1SES
1
1
BADGE
Hot applicable
Not applicable
BEAM
1.9 ug/g
2.4 ug/g
GEBEBAL IHPOBBATIOH
After 90-120 nl ipecac syrup/day
(63-81 rng enetine) over 3 mo. Total
consumption 5.67 to 7.56 g eoetine
Autopsy samples.
26 yr old, slightly over»eight
At admission, narked shortness of
breath, heart palpitations, chest
tightness, exertional dyspnea,
eitreie fatigne, blood pressure 75/60
«• Hg, pulse rate 150. Increased
hypotension over next 2<» hr until
terminal vertricular tachycardia and
fibrillation developed.
PERICARDIA! FLUID: PEBNSYI. VANIi;
ADOITS; AUTOPSIES: BI1E; B100D;
CEEEBSOSPIBAL F1DID; KIDSETS; II/ER;
DEOG ABUSE; DRUGS; BLOOD PRESSURE
After 90-120 »1 ipecac syrup/day
(63-8 1 Big eaetine) over 3 10. Total
ccnsuiption 5.67 to 7. 56 g eietine
Autopsy sanples.
26 yr old, slightly overweight
At admission, narked shortness of
breath, heart palpitations, chest
tightness, exertional dyspnea,
cxtreae fatigue, Plood pressure 75/60
•• Hg, pulse rate 150. Increased
hypotension over next 2» hr until
terminal vertricular tachycardia and
fibrillation developed.
PEFIC1EDIA1 JLOII;
1MITS; JBTOPSIES; BILB; BLOOD;
CEBEBROSPIHAL FIDID ; KIDHEtS; LIVES;
DECS ABUSE; DRUGS; BLOOD PRESSURE
Adler, A.G.
Walinsky, P.
Krall. R.A.
Cho, S.Y.
1980
Journal of the Anencan
Nedical Association
213(19! :1927-1928
LO
ON
to
Adler, A.G.
Walinsky, P.
Krall, B.A.
Cho, S.Y.
1980
Journal of the American
Medical Association
213(19) :1927-1928
(IEIT PASS)
-------
Eietine (8 CI)
Eietan, 6' ,T , 10 , 11-tetra«ethoiy- (9 CI)
1183-18-1
C29-H10-K2-01
BW 480.63, HP 74 C
(COHTINOED)
TISSUE
1175
Cerebrosp
inal
fluid
7176
KLiaey
7177
Liver
EXPOSORE BOOTE
Ingestion
Ingestion
Ingestion
AMLYTICJI.
BETHOD
TIC
TIC
0»
HUB BEE
OF CASES
1
1
1
BADGE
Hot applicable
Not applicable
__
Not applicable
HEAD
0.1 ug/g
7.4 ug/g
14.0 ug/g
GENERAL INFORMATICS
After 90-120 nl ipecac syrup/day
(63-81 ng emetine) over 3 no. Total
consunption 5.67 to 7.56 g emetine
Autopsy samples.
26 yr old, slightly overweight
At adaission, marked shortness of
treat h, heart palpitations, chest
tightness, exertional dyspnea,
extreme fatigue, blood pressure 75/60
nm Hg, pulse rate 150. Increased
hypotension over subseguent 2tt hr
until terminal vertricular
tachycardia and fibrillation
developed.
PEPICAFDIAL ?LOTD; PENNSYLVANIA;
ADULTS; AUTOPSIES; BIIB; BLOOD;
CERF.BROSPINAL PLOID; KIDNEYS; I.IVRB;
DRUG ABUSE; DRUGS; BLOOD P8BSSURE
After 90-120 ml ipecac syrup/day
(63-9U ing enetine) over 3 ao. Total
consumption 5.67 to 7.56 g emetine
Autopsy samples.
26 yr old, slightly overweight
At admission, narked shortness of
treat h, heart palpitations r chest
tightness, exertional dyspnea,
extreme fatigue, blood pressure 75/60
am Hg, pulse rate 150. Increased
hypotension over next 2U hr until
terminal vectricular tachycardia and
fibrillation developed.
PERICARDIA! FLCirD; PESNSYXVAKIA;
ADOLTS; AUTOPSIES; BILE; BIOOD;
CEPEBROSPIHAL FLUID; KIDNEYS; 1IVEB;
ERDG ABUSE; DRUGS; BLOOD PRESSURE
After 90-120 ml ipecac syrup/day
(63-81* aq eaetine) over 1 BO. Total
consueption 5.67 to 7.56 g enetine
Autopsy sanples.
26 yr old, slightly overweight
At admission, marked shortness cf
breath, heart palpitations, chest
tightness, exertional dyspnea,
extreme fatigue, blood pressure 75/60
nm Hg, pulse rate 150. Increased
hypotension over next 21 hr until
terninal vertricttlar tachycardia and
fibrillation developed.
FEPIC4PDIAL FtOID; PENNSTLVANIA;
ACOLTS; AUTOPSIES; BILE; BIOOD;
CES5BSOSPINAL FLUID; KIDNEYS; LIVER;
DBHG ABDSE; DRUGS; BLOOD PRESSURE
Adler, A.G.
Halinsfcy, p.
Krall, R.A.
Cho, S.Y.
1980
Journal of the American
Hedical Association
213(19) M927-1928
Adler, A. (3.
Halinsky, p.
[trail, 6.4.
Cho, S.Y.
1980
Journal of the American
Medical Association
243( 19) : 1927-1928
CO
O
U>
Adler, A.G.
Halinsky, P.
Krall, P.A.
Cho, S.Y.
1980
Journal of the Auerican
Bed ica1 Ass oc i at ion
2<*3<19) :1927-1928
(NEXT PAGE)
-------
Emetine (8 CD
Emetan, 6 ', T, 10, 11-tetramethoxy- (9 CI)
483-18-1
C29-H40-d2-04
BS 480.63, HP 11 C
(CONTINUED)
TISSUE
7178
Pericardi
al fluid
TISSUE
7179
Blood,
plasma
EXPOSURE BOUTE
Ingestion
ANALYTICAL
METHOD
TLC
NUMBER
OF CASES
1
BANGE
Not applicable
MEAN
0.7 ug/g
GENEfiAL INFORHATIOH
after 90-120 •! ipecac syrup/day
(63-84 rag emetine) over 3 BO. Total
consumption 5. 67 to 7, 56 g enet ine
Autopsy samples.
yr old, slightly overweight
At admission, marked shortness of
breath, heart palpitations, chest
tightness, exertional dyspnea.
extrene fatigue, blood pressure 75/60
mm Hg, pulse rate 150. Increased
hypotension over next 2* hr unt il
terminal vertricolar tachycardia and
fibrillation developed.
FEEICABDIAL FLUID; PENNSYLVANIA;
ACOLTS; AUTOPSIES; BILE; BLOOD;
CBBEBSOSPISAL FLUID; KIDHEYS; LIVEB;
DBDG ABD5E; DRUGS; BLOOD PRESSURE
_
BEFEBENCE
Adler, A. 6.
Halinsky, P.
frail. 8. A.
Cho, S.T.
1980
Hedical Association
243(19) :1927-1928
1
navigated {So postings in CHEHLIBE) .
EXPOSURE BOUTE
Vaginal
ANALYTICAL
METHOD
EIA
HUH BEE
OF CASES
a) 6
b) 6
c) 4
d> 5
e) 11
f) 14
BANGB
a) Sot given
b) Not given
c) Hot given
d) Hot given
e) Not given
f) Not given
HEAN
a) 47.7 +oc- 5.0
pg/ml
b) -0.7 +or- 9.0
pg/ml
c) 103.0 +or- 16.4
pg/ml
d) 35.8 +or- 7.0
pg/ml
e) 125.3 + or- 20.1
pg/ml
f) 93.7 +or- 11.7
pg/ml
Changes from basal
level
GENERAL INFORHATICN
a) 0.3 mg/day oral
b) 0.3 mg/day vaginal
c) 0.625 ag/day oral
d) 0.625 eg/day vaginal
e) 1.25 ng/day oral
f) 1.25 mg/day vaginal
After 1 wk therapy with conjugated
estrogen preparation
Basal level 25-62 pg/»l
Vaginal application therapeutically
effective, even at 0.3 ng/day.
level
ADULTS: BLOOD PLASHA; DRUG THERAPY:
DRUGS; BORHONES;
REFERENCE
Deutsch, S.
Ossovski, R.
Benjamin, I.
1981
American Journal of
Obstetrics aad
Gynecology
139(8) :967-968
-------
Ethyl alcohol (8 CI)
Ethanol (9 CI)
6 It-17-5
C2-H6-0
B« 116.07, HP -117.3 C, BP 78.32 C, VP 40 II Hg at 19 C
TISSUE
7180
Blood
1181
Blood
7182
Blood
7183
Blood
7181
Blood
EXPOSURE ROUTE
Ingestion
Inqestion
Ingestion
IHllYTICAl
HETHOD
GC
TLC
TJV
GC/HS
Enzymatic
Enzymatic
GC
HOaBEB
OF CASES
a) 1
b) 1
a
12
4
46
BINGE
a) 1100-1240 «a/l
b) 0-560 »g/l
13.5-34.0 »»ole/l
a) 130-10 «g/100 ml
b) 120-10 ng/100 ml
0.08-0. 18X
(weight/weight)
O.Ot-G.38 nig/100 ml
HEAN
a) Not given
b) Not given
23. 1 +or- 1.3 mmole/1
a) Not given
b) Not given
Not given
Not given
GENERAL INFORMATION
a) Dose probably less than toxic
amount
b) Patient denied taking drug
Results from i| laboratories receiving
identical samples for toxic screen
Overdose drugs identified in 501-70%
of cases. Laboratories agreed on 6
of 23 drugs reported present in the
serum of 20 pateints
Levels variable and appeared
imprecise.
Probable drug overdose patients.
Boston, HA
MASSACHUSETTS; BLOOD; ANALGESICS;
ANTICONVULSANTS; ANTIDEPRESSI VE
AGENTS; ANTIPYFSTICS; DBOG ABOSE;
DRUGS; HYPNOTICS; KAHCOTICS;
SEDATIVES; TRANQUILIZERS ; COMPARATIVE
EVALUATIONS; ALCOHOLS; HBASOREHENT
METHODS
0.73 g/>g loading dose (30 ain after
15 ng antipyrine) and 0.73 g/Vg
maintenance dose for 12 hr. Range of
means at 3, 6, 9, and 12 hr
Healthy 22-60 yr olds, wt H8-95" kg
Ithanol caused no change in the
half-life, distribution volume, or
clearance of antipyrine
ADULTS; BLOOD; DRUG INTERACTION;
DRUGS; ALCOHOLS
a) 100 and 720 min after 1.t(3 q/kg
b) 100 and 720 min after 1.H3 gAg-
Chlormethiazole given at 230 and 650
• in
Healthy 21-46 yr old moderate
drinkers
BLOOD; DRUG THERAPY; DRUGS; ALCOHOLS;
ALCOHOLIC BEVERAGES
Intracranial blood clots from victims
surviving up to 13 hr after severe
Peripheral blood 0-0.02'
(weight/volume) .
AUTOPSIES; BLOOD; BRAIN; DRUG ABUSE;
DRUGS; FORENSIC HEDICINE; ALCOHOLS
Drug induced fatalities. Other drags
also found.
Autopsies, 1975-76, Los Angeles
County, CA
CALIFORNIA; AUTOPSIES; CASE
HISTOBIF-S; BLOOD; D RIG ABUSE; DBDGS;
FOBENSIC MEDICINE; ALCOHOLS
REFERENCE
Inge If inger, J.A.
Isakson, G.
Shine, D.
Costello, C.E.
Goldman, P.
1981
Clinical Pharmacology
and Therapeutics
29(5) : 570-575
Dossing* M.
Andreasen, P. B.
1981
Clinical Pharmacology
and Therapeutics
30(1) : 101-104
_
Hyrsten, A,L.
Rydberg, U.
Idestrom, C.M.
Lamble, R.
1980
Psychopharmacology
69:117-125
Freireich, A.M.
Bidanset, J.R.
1S75
Journal of Forensic
Sciences 20 (1) :83-85
Nakamurar G.R .
Noguchi, T.T.
Griesemer, E.G.
1979
Journal of Ana lytical
Toxicology 3:137-142
(SEXT PAGE)
-------
Ethyl alcohol (a ci)
Fthanol (Q CI)
6 q- 17-5
C2-H6-C
PW H6.Cn, IP -117.3 C,
78.32 C, VP 110 mm
TTSSU17
TIBS
Blool
HRfi
PloO'3
7187
Ploqa
7188
Blood
7189
Blood,
plasma
FXFOSUB? ROUTE
Inqestion
A NALYTICAL
TCTFCD
GC
GC
GC
GC
NUMBER
Of CBSES
501
39
a) 69
*) 112
14
flANGS
a) 300-349 mg/UQ ml
D) 350-399 mj/100 ml
c» >or=430 mg/100 ml
a) Sot detected
b) 30-99 mg%
c) 100-199 mg%
d) 200-400 ag9E
a) >0.05 g/100 ml
b) >0.10 g/100 ml
c) >0. 15 g/100 ml
a) 20-420 rng/dl
b) 10-500 mg/ai
a) Not given
b) Hot given
C) Sot given
tfEAN
a) Not given
D) sot given
J) Not given
a) Mot given
a) Not given
c) hot given
d) Not given
a) Not given
fa) Not given
c) (jot given
a) Not given
b) Not given
a) 97.7 *or- 19.7
mg/dl
b) 73.4 +or- 10.4
«g/dl
c) 108.7 -tor- 20.8
rng/dl
GENERAL IHFOSBaTIOH
a) 03 of 20U unnatural deaths
b) 38 of 113 vinr. atural deaths
c) 132 of 184 unnatural deaths
Deaths attributed solely to acute
ethanol poisoning
Xutopsy flata, 2* mo period
Data also by race, sex, age, cause
and place o£ death, day of death.
occupation, population density, and
from other areas of the U.S.
Whites, Blacks, and American Indians,
age 16->80 yr, with blood ethanol
>300 ng/100 il, NC
SOUTH CSR01IHI1: »GE ; RICHL STUDIES;
SEX; BLOOD; DROG »BOSE; DBDGS;
CC«PAB»TI¥E EV1L01TIOSS; ALCOHOLS
a) 13 drivers
b) 5 drivers
c) 10 drivers
d) 11 drivers
Ocivecs fatally injured in single car
crashes. nean level 180 ngf. In two
cases phenobarbital or propoiyphene
also detected.
north Carolina
NORTH CABOLIHA; BLOOD; HIHJG ABUSE;
EEDGS; A ICO HOLS
a) 21. 3J, 17. 8K, 27. It, 8.7*
b) 16. 3J. 12.2*, 21. OS, 6.0%
c) 10. 6*, 7.3Jf, 13. 7X, 3.7*
Mean percentages, 197U-1977, of road
accident casualties, for 35,591
drivers, respectively
Victoria, Australia
AUSTRALIA; BLOOD; BBOG ABUSE;
ALCOHOLS; ALCOHOLIC BEVERAGES
a) Deaths involving morphine and
ethanol
b) Deaths involving morphine, quinine
and ethanol
Dayne County, HI
MICHIGAN; ABTOPSI1S; DRDO ABUSE;
DROSS; NARCOTICS; PSYCHOTBOPIC DRUGS;
SEDATIVES
a) Before
delta-9-te trahyirocannaM.no! (THC)
b) During THC
c) After THC
Dose 1 ml 95* ethanol/kg. THC 10
mg/l hr for 1C days. Three other
patients showed no decrease during
THC
Healthy 20-29 yr olds
BLCOD PLASHA; DBUG ISTEB SCTION ;
DKOGS; SEDATIVES; RETABOLISH
BEFEBESCE
Taylor, H.L.
Hudson, E.P.
1977
Journal of Forensic
Sciences 22(3) :639-653
Turk, fl.F.
BcBay, A.J.
Hudson, P.
1970
Journal of Forensic
Sciences 19(1) :90-97
BcDermott, F.
strang, P.
1976
Medical Journal of
Australia 2(1 «) : 612-615
Honf orte, J.B.
1977
Journal of Forensic
Sciences 22 (H) :7 18-724
Benouitz, H.L.
Jones, R.T.
1977
Clinical Pharmacology
and Therapeutics
22(3) :259-268
(NEXT PAGE)
-------
Ethyl alcohol (8 CI)
Ethanol (9 CI)
61-17-5
C2-H6-0
FIB H6.07, »P -117.3 C, BP 78.32 C, VP 10 mm flg at 19 C
(CONTINUED)
TISSUE
7190
Blood,
serum
7191
Blood,
serun
7192
Brain
_
EXPOSURE EOniE
Inqest ion
Injection
Ingestion
ANALYTICAL
METHOD
GC
StMBEB
OF CASES
1
8
K
BANGS
Not applicable
a) 159-13 mg/100 .1
b) 178-8 mg /100 »1
c) 153-5 «g/100 «1
0.05-0. 13*
(weight/weight)
BEAK
0.90 g/1
a) Not given
b) Not given
c) Not given
Not given
GENERAL INFOKHATICN
Unknown dose of ethanol-isopropanol
45 yr old
BLOOD SERDH; DRUG ABUSE; DRUGS;
ALCOHOLS
a) 1 g/kg IV, plus 2 g/kg glucose,
oral
b) 1 q/kg IV, plus 2 gAg fructose.
c) 1g/kg IV, plus 4 g/kg sucrose,
oral
1 hr and 5-6 hr (roe an) after dose.
Alcohol removal rate significantly
lower with b) and c) than with a)
25-53 yc old chronic alcoholics,
normal liver function, abstained from
BLOOD SEBOM; DRUG IHTEEACTIOH ; DBOGS;
SEDATIVES; BETABOIISH
Victias surviving up to 13 hr after
severe head injury while intoxicated.
Peripheral blood levels 0-0. 02?
(Height/volume)
AUTOPSIES; BLOOD; BEAIN; D BOG ABUSE;
DBtJGS; FOBEHSIC MEDICINE; ALCOHOLS
HEFEBEHCE
Vasiliades, J.
Pollock, J.
Robinson, C.A.
1978
2»(2) : 383-385
soterakis, J.
Iber. ?.L.
1975
Clinical Nutrition
28:251-257
Freireich, l.H.
Bidanset, J.H.
Lukash, L.
1975
Journal of Forensic
Sciences 20 (1) :83-85
Ethylanine, 2-(diphenyliethoiy)-N,»-diiethyl- (8 CI)
Ethanamine, 2-(diphenyliethoiy)-S,N-di«ethyl- (9 CI)
58-73-1
C17-H21-N-0
BB 255.35. BP 150-165 C at 2.0 «n Kg
TISSDE
7193
Blood
EXPOSURE ROUTE
ANALYTICAL
9ETHOD
N OK EBB
OP CASES
1
BANGS
Not applicable
SEAN
0.80 ug/100 &1
GENERAL INFORMATION
Drug induced fatality. Ethanol, 0.29
g/100 ml, also found.
Autopsy, 1975-76, Los Angeles county.
c»
CALIFORNIA; AUTOPSIES; CASE
HISTORIES; BLOOD; DRUG ABUSE; DRUGS;
FORENSIC flEDICINE; ALCOHOLS
BEFE8EKCE
..
Hakanura, 3.R.
Moguchi, T.T.
Griesemer, B.C.
1979
Journal of Analytical
Toxicology 3:U7-I
-------
Ferritics
9007-73-2
IXiCT COBPOSITIOH ONKBOBS OE ONDETEBBIHED
7191
Blood,
serun
EXPOSOEE SOOTE
Injection
ANALYTICAL
BETHOD
HUMBEB
OF CASES
2
BAHGE
230-240 ug/1
-
Hot given
GESERJ1 INFOBSATIOH
Peaks, 7-9 days after 1-2 g elemental
Fe
Estimated from graph
68 and 76 yc old anemias
B100D SEEOH; D80G THEE1PT; DRUGS;
I80H; (lETALS; AHEBIA
BEFEEENCE
Blunden, R. H.
Lloyd, J.V.
Radzki, Z.
Kiibec, 8.J.
1981
Annals of Clinical
Biochemistry 18:215-217
Fluoride
1698U-18-8
F
AtW 18.9980
TISSOE
7195
Blood,
serum
7196
Blood,
serum
EXPOS0BE ROOIE
Inhalation
Ingestion
1 ANALYTICAL
HETHOD
ISE
.
NUflBEE
OF CASES
18
20
BANGE
a) Not given
b) 10.7-1.8 UB
a) 0.01-0.023 ppm
b) 0.02-0.05 pp>
c) 0. 035-0. OH5 ppm
.
a) 3.4 uM
b) Not given
a) 0.016 ppH
b) 0.029 ppa
c) 0.040 ppa
(NEXT PAGE)
G2HEBM ISFORHfcTICIS
a) P tee x po s u re 1 e ve 1
fcj 3 and 2U hr after 0.6-2* with
nitrous oxide, 60* in oxygen
Irogranic fluoride
fiange of neans
Patients undergoing ear- surgery and
receiving enflurane anesthesia
ADOLTS; BLOOD SEEUH; &HBSTHETICS;
DRUG THERAPY; DRDGS; PLOORIDE
a) Basal diet (0.43 ag F/day) for 5-9
wk, 5 sub jects
b) Basal diet plus 5 ag 7/day
supplement for 4 trie, (aean F intake
5.40 ng/day) , 8 sub jec ts
c) Basal diet pins 10 mg F/day
supplement for 5 wfc» (mean F intaVe
10.38 ng/day), « subjects
Supplement given as 2.2 ng sodium
fluoride tablets in divided doses
with aeals
Biweekly saaples
Range estimated froa graph
Healthy volunteers, 20-45 yr old
(Bean, 32 yr), wt 60-88 kg (Bean 70
kg), 158-188 ca (mean 174 ca) , CA
CALIFORNIA; ADULTS; BLOOD SEBOH;
ORIHE; FLOOHIDE; BIOACCOHOLATION;
DIETS
Duvaldestin, P.
Hauge, F.
Desnonts, J.-H.
1981
Clinical Pharmacology
and Therapeutics
29{1):6l-64
Mabeshvari, U.R,
IcDonald, J.T.
Schneider, V.S.
Brunetti, fi.J.
Leybin, L.
Newburn, E.
Hodge, B.C.
1981
Aaerican Journal of
Clinical Nutrition
34:26T9-268t|
OO
-------
Fluoride
16984-48-8
F
AtB 18.99814
(CONTINUED)
TISSUE
7197
Urine
7198
Drine
EXPOSOSE ROUTE
Ingestion
Ingestion
ANALYTICAL
METHOD
__
HOMBEB
OF CASES
20
3
BINGE
a) 0.53-0.98 mg/day
b) 3. 14-4. 12 mg/day
o) 5.78-7.47 mg/day
a) Not given
b) Hot given
c) Not given
d) Not given
e) Not given
f) Hot given
g) Not given
h) Not given
a) 0.7 Bg/day
b) 3.5 sg/day
c) 6.76 mg/day
a) 2.9 »or- 0.13
Bg/day
b) 3.2 »or- 0.31
mg/day
c) 2.9 »or- 0.40
mg/day
d) 2.9 »or- 0.31
mg/day
e) 7.8 *or- 0.66
mg/day
£) 7.8 »or- 0.70
mg/day
g) 7.4 tor- 0.95
mg/day
h) 7.4 tor- 0.87
•g/day
GENERAL INFORMATION
a) Basal diet (0.43 mg F/day) for 5-9
wk, 9 subjects. Mean f balance,
-0.40 Bg/day
b) Basal diet plus 5 sg/day f
supplement for 4 wk (mean F intake
5.40 Bg/day), 8 subjects. Mean F
balance +1.38 mg/day
c) Basal diet plus 10 mg/day
supplement for 5 wk (mean F intake
10.38 mg/day), 4 subjects. Bean F
balance +2.38 Bg/day
Supplement given as 2.2 Bg sodina
fluoride tablets in divided doses
with meals
Healthy volunteers, 20-45 yr old
(mean, 32 yr) , »t 60-88 kg (mean 70
kg), 158-188 CB (Bean 17» cm), CA
CALIFORNIA; ADULTS; BLOOD SESDM;
URINE; FLDOEIDE; BI0 ACCUMULATION;
DIETS
a) 4.0 Bg/day
b) 4.1 Bg/day
c) 3.9 mg/day
d) 4.4 Bg/day
e) 13.1 mg/day
f) 13.2 mg/day
g) 1"3.8 mg/day
h) 13.6 mg/day
Intake in a)-d) from diet and
fluoridated drinking water, in e)-h)
from diet, fluoridated drinking
water, and supplement of Na fluoride.
Ca and P given simultaneously had no
significant effect.
Metabolic research ward patients
ILLINOIS; URINE; C1LCIOB; FLUORIDE;
PHOSPHORUS; METABOLISM
Maheshwari, 'i.e.
McDonald, J.T.
Schneider, V.S.
Brunetti, A.J.
Leybin, L.
Newburn, E.
Hodge, B.C.
1981
American Journal of
Clinical Nutrition
34:2679-2684
Spencer, H.
Osis, D.
Kraaer, L.
WUtrowski, E.
Norris, C.
1975
Journal of Nutrition
105:733-740
-------
Flupentixol (Ho postings in CHEMLINE) .
2709-56-0
C23-H25-F3-H2-0-S
»S H34.54
TISSOE
7199
Blood,
plasma
EXPOSUBE ROOTS
Infection
Ingestion
_
ANALYTICAL
METHOD
BIA
NUMBER
OF CASES
2
BADGE
a) 31-22 ug/1
b) 1-6.5 ug/1
c) 5-19 ug/1
d) 7-13 ug/1
flEA»
a) Sot given
b) (Jot given
c) Not given
d) Hot given
GENERAL INFOHflATICN
3} 2 and 2U hr after 12 ng, oral.
Fluctuation 2-7 hr* then gradual
decline for 7 days, 1 subject
b) 0-7 days after 20 mg
sustained-release preparation, 11, 1
subject
c) 0-7 days after 10 nq
sustained-release preparation, Irt,
subject in b)
d) 0-7 days after 2nd 10 nq
subject in b)
t> , cj , d) levels increased to peak
level at 1ft days
Estimated fron graph
Earfcinsonian side-effects beginning 7
hr after administration and recurring
over next U8 hr with oral dose.
BICOD PLASHi; DBOG IHTEl&CTIOB; DROG
THERAPY; DRUGS; TEAHQUILIZERS;
HEASDBEnENT METHODS
REFERENCE
Robinson, D.
Eisby, D.
1977
Clinical Chemistry
23(11) :2085-2Q88
GlutariBide, 2-ethyl-2-pheoyl- (8 CI)
2,6-Piperidinedione, 3-ethyl-3-phenyl- (9 CI)
77-21-11
C13-H15-N-02
H» 217.26, 9P dl fora 6H C
OJ
•^J
O
7200
Blood
7201
Blood,
plasaa
BXPOSOHB FOOTE
Ingestion
.
ANALYTICAL
HITHOD
GC
GC
HOBBEB
or CASES
1
1
BANGS
Not applicable
...
a) 12.1-3.8 ug/«l
b) 16.8-22.7 ug/il
BEAN
0.59 »9/100 •!
a) Not given
b) Not given
GENERAL INFOS NATION
Drag induced fatality. Phenytoin,
0.1 ag/100 «l, also found.
Autopsy, 1975-76, Los Angeles County,
CA
CALIFOFHIA; AUTOPSIES; CASE
BISTOEIES; B100D; DRUG ABUSE; DBTCS;
POBENSIC SECICINE; ALCOHOLS
a) 7.5 and 21 hr after 6 g
b) 7.5 and 11 hr after 6 g. Final
neasurenent 20.3 ug/al at 21 hr.
Betabolite
(4-hydroxy-2-et hyl-2-phenylqlutari«id
e)
Range of Beans
In cooa for 30 hr
AUTOPSIES; BLOOD PLASHA; BRAIN;
KIDHETS; LITER; DROG ABUSE; DHOGS;
BIPBOTICS; SEDATIfBS; BETABOLITES
BEFERESCE
Nakaaara, G.R.
Noguchi, T.T.
Griesener, B.C.
1979
Journal of Analytical
Toiicology 3: 137-112
Hansen, A. B.
Fischer, L.J.
197»
Clinical Cheilstry
20(2) :236-2«2
(NEXT PAGE)
-------
Glutarinide, 2-ethyl-2-phenyl- (8 CI)
2,6-PiperidiDedione, 3-ethyl-3-phenyl- !9 CI)
77-21-4
C13-H15-N-02
»S 217.26, Sf 31 fom 814 C
(CONTINUED)
TISSUE
7202
Blood,
plasna
Blood,
serum
7204
Brain
Cerebrosp
inal
fluid
7206
Kidney
EXPOSURE ROUTE
AHAITTICAL
METHOD
GC
GC
GC
NU8BEB
OF CASES
1
a) 1
b| 1
1
BANGS
a) Hot applicable
b) Not applicable
c) Hot applicable
b) 7-72 mg/1
a) 71-72 ug/g
bj 3-6 ug/g
c) 5-7 ug/g
d) 13-16 ug/g
b) 1-19 mg/1
a) 9-11 ug/g
b) 34-39 ug/g
BEAN
a) 34 «g/l
b) 31 «g/l
c) 8 mg/1
b) Not given
a) 72 ug/g
b( 5 ug/g
c) 6 ug/g
d) 44 ug/g
b) Not given
a) 10 ug/g
b) 37 ug/g
GENERAL INFORMATION
a) 24 hr after admission.
b) 36 hr later, at beginning of
charcoal he noper fusion
c) After 11.5 he hemoperf usion
Dose unknown
yr o
Unconscio us, hypotensive.
hypot heroic, aref lexic , hy poric
UNITED KINGDOM; ADOLESCENTS; ADULTS;
CASE HISTORIES; BLOOD PLASMA; DRUG
ABUSE; DROGS; HYPNOTICS; HDSCLE
RELAX AHTS; THEOPHYLLISES
<0-82.5 hr) following overdose
t) Same as a). Three associated
compounds (eluting near glutethinide
on GC column)
Doses not reported
BIOOD SFROJT; CEREBROSP INAL PLfTID;
DRDG ABUSE; DRUGS; SEDATIVES;
METABOLISM
a) 2 autopsy sa nples
b) Same as a), metabolite
{1-hydroxy-2-ethyl- 2-phenyl glut aria id
e) (U-HG)
c)2 autopsy samples
fl) Saaie as c) , netabolite (4-HG)
Dose unknown
AUTOPSIES
BICOD PLASHA
EBAIN
KIDNEYS
LIVE5
DRUG ABUSE
DRUGS
HYPNOTICS
SEDATIVES
METABOLITES
following drug overdose
b) Same as a). Associated conpound
eluting near glutet hinide en GC
coluotn
Doses not reported
Duration of coma 0-82.5 hr
BIOOD SERUfl; CEEHBROSP ItJAL FLUID;
DRUG ABUSE; DRUGS; SEDATIVES;
KETABOLISH
a) 2 autopsy samples
b) Same as a) , metabolite
(tt-hydroxy-2-ethy 1-2-phenylglutarimid
e)
Dose unknown
AUTOPSIES; BLOOD PLASMA; BRAIN;
KIPHEYS; LIVER; DRUG ABUSE; DRUGS;
HYPNOTICS; SEDATIVES; METABOLITES
REFERENCE
Haper, S.
croae, P.
Vale, A.
Hellinell, B.
Widdop, B.
1982
«9:303-310
Tassoni f E.
Etzi, n.
Plathew, G.
1974
Clinical Cheaistry
20(2): 195-199
Hansen, A.R.
Fischer, r.. J.
1974
clinical chemistry
20(2) :236-242
Tassoni, E.
Etzl, H.
nathev, G.
1974
Clinical chemistry
20 (2) : 195-199
Hansen, A.R.
Fischer, L.J.
19714
Clinical chemistry
20(2) :236-2»2
(NEXT PAGE)
-------
Glutarimide, 2-ethyl-2-phenyl- (8 CI)
2,6-Piperidinedioue, 3-ethyl-3-phenyl- (9 CI)
77-21-1
C13-H15-N-02
BW 217.26, HP dl form 81 C
(CONTINUES)
TISSUE
7207
Liver
7208
Liver
EXPOSURE ROUTE
ANALYTICAL
BETBOD
GC
GC
07
NUBBER
OF CASES
1
RANGE
a) 166-211 ug/g
b| 8-9 ag/q
b) Hot applicable
HE»S
a) 190 ug/g
b) 8 ug/g
b) 6.1 mg/IOOg
GENERAL INFORHATIOS
a) 2 autopsy samples
b) Same as a), metabolite
(1-hydrory-2-ethyl-2-pheny Iglutarimid
e)
Dose unknown
AUTOPSIES; BLOOD PLASH*; BRAIN;
KIDNEYS; LIVER; DRUG ABUSE; DRUGS;
HYPNOTICS; SEDATIVES; BETABOLITES
b) XAD-2 resin bag extraction method
Fatal overdose case
Poland
POLAND; BLOOD; BBAIN; LI7EH; DROG
ABUSE; DRDGS; HEASDRBBENT BETHODS
REFERENCE
Hansen, A.R.
Fischer, L. J.
197U
Clinical Chemistry
20 (2): 236-212
Gierz, J.
Bialka, J.
1978b
Foceixsic Sciance
Guanidine, N-cyano-B'-iethyl-N' •-(2-(((S-«ethyl-1B-i«idazol-1-yl) uethyl) thio) ethyl) -
51181-61-9
C10-H16-N6-S
BB 252.38
TISSUE
7209
Blood,
plasma
EXPOSURE ROUTE
Ingestion
ANALYTICAL
BETHOD
HPLC
NOB8EB
OF CASES
8
BANSE
-
0.80-1.75 ug/il
HEAN
Not given
GENERAL INFORSATION
_ -
Pange of mean steady state levels
after 300 «g IX/day for 7 days. ADC
10C-850 ug/mlX»in
Healthy 21-12 yr olds.
cimetidine reduced liver blood flow
and aetabolisB of propranolol. Pulse
rates at rest also reduced.
ADULTS; BLOOD PLASMA; DRUG
INTERACTION: DRUG THERAPY; DRUGS
REFERENCE
Feely, J.
Wilkinson, G. R.
Hood, A.J.,7.
1981
New England Journal of
Medicine
301(12) :692-695
OJ
-------
Heparin
9005-»9-6
EXACT COMPOSITION ONKNCHN OH UNDETERMINED
BB 6000-20,000
TISSOE
7210
Blood,
plasna
EXPOSURE ROOTE
Injection
ANALYTICAL
BETHOD
Photonetry
NOB BEE
OF CASES
a) 8
b) e
c) 7
d) 10
BANGS
a) Not given
b) Not given
c) Hot given
d) Hot given
BEAN
a) 2.00 *or- 0.33
0/»1
b) 1.56 *or- 0.68
U/ml
c) 1.52 *or- 0.57
5/nl
d) 1.17 *or- 0.58
0/rnl
GENERAL INFORBATIOH
a) Healthy adults, 75 D/kg, IV
b) Infants, 33-36 vk gestation, 100
0/kg, IV
c) Infants, 29-32 vk gestation, 100
a/kg, IV
d) Infants, 25-28 wk gestation, 100
a/kg, IV
Initial level after bolus infusion as
Na salt
b) ,c) ,d) dose given within 4 hr after
birth. Clearance rate significantly
greater in infants than in adults.
Healthy adults and newborns, vt
3210-680 g, 3 small for gestational
age, 2 twins, 7 with transient
tachypnea, 17 with hyaline aenbrane
disease, 1 with pneumonia, 2 infants
of diabetic mothers.
; NEWBORN; BIOOD PLASHA;
ANTICOAGULANTS; DROGS; HBASOREBENT
METHODS
ScDonald, H.H.
Jacobson, L.J.
Hay, «.»., Jr.
Hathaway. W.E.
1981
Pediatric Research
15:1015-1018
Hydantoin, 5,5-diphenyl- (8 CI)
2,1-Imidazolidinedione, 5,5-diphenyl- (9 CI)
57-41-0
C15-H12-N2-02
BB 252.26, BP 295-298 C
OJ
TISSUE
7211
Blood
7212
Elood,
plasna
1
1
EXPOSURE ROOTS
Ingestion
ANALYTICAL
BETHOD
GC
TLC
0V
GC/BS
Enzymatic
GC
NUMBER
OF CASES
2
i
RANGE
0-26.0 rcg/1
97-25 »g/l
Hot given
Not given
GEHEEiL INFORMATION
Dose probably less than toxic amount
Desalts f ron <* laboratories receiving
identical samples for toxic screen
Overflose drags identified in 50)1-70%
of cases
Laboratories agreed on 6 of 23 drugs
reported present an serum of 20
patients
Levels were variable and appeared
imprecise.
Probable drug overdose patients,
Boston, MA
MASSACHUSETTS; BLOOD; ANALGESICS;
ASTICONVOLSAHTS; AHTIDEPHFSSIVB
AGENTS; ANTIPYRETICS; CROG ABOSE;
DEDGS; HYPNOTICS; HiBCOTICS;
SEDATIVES; TRANQDILIZERS; COMPARATIVE
EVALUATIONS; ALCOHOLS; nBASUSEHENP
MITHODS
« and 11 days after estinated 100
100-nq Dilantin capsules plus 50 250
ng Hysoline tablets. Initial
neasurenent, 56.5 ng/1 about 90 ain
after overdose.
lethargic, atoiic and dysarthric in
Stage II cona. Borderline
intraventricular conduction delay and
a sinus tachycardia (110 beat per
Bin) .
SUICIDE; BLOOD PLASMA;
AHTICONVOLSANTS; DRUG ABUSE; DROGS
(NEXT PAGE)
REFERENCE
Inge If inger, J .A.
I sate son, G.
Shine, D.
Costello, C.E.
Goldman, P.
1981
Clinical Pharaacology
and Therapeutics
29 (5): 570-575
Hatzke, G.R.
Cloyd, J.C.
Sawchuk, B.J.
1981
Journal of Clinical
Pharmacology 21:92-99
-------
Hydantoin, 5 ,5-diphenyl- (8 CI)
2,4-Imidazolidinedione, 5, 5-diphenyl- (9 CI)
C15-H12-N2-02
BW 252.26, HP 295-296 C
(CONTINUED)
TISSDE
Blood ,
plasma
721(1
Blood,
plasma
7215
Blood,
plasma
EXPOSURE ROUTE
Ingestion
Ingestion
Ingestion
ANALYTICAL
METHOD
Enzymatic
GC
GC/BS
NONBEB
OF CASES
a)
b)
c)
d)
e)
f|
a-c) 1
d-t) 1
RANGE
a) 3,3-21.9 mg/1
b| 3.8-22.7 mg/1
c) 2.95-25.4 mg/1
d) 3.i»-29.9 mg/1
a) Hot applicable
b) Not applicable
c) Not applicable
d) 7-1.5 ug/ml
e) 4.6-3 ug/»X
f) 4.3-3 ug/«l
a) 4.3498-0.0178 ug/ml
b) 0.0602-0.0121 ug/ml
c) 1.6248-0.0114 ug/ml
d) 5.2586-0.0232 ug/al
e) 0.1200-0.0145 ug/ml
£) 2.1725-0.0359 ug/ml
(KBIT
BEAN
a) 9.6 mg/1
b) 11.9 mg/1
c) 8.8 mg/1
4) 10.2 mg/1
a) 6.6 ug/al
b) 1.3 ug/al
c) 6. 5 ug/»l
d) Not given
e) Not given
f) Not given
a) Not given
b) Dot given
c) Not given
d) Hot given
e) Not given
t) Dot given
PAGE)
GENERAL INFORBATIOB
a) Days 4-6 of 20 day study period.
ethanol ingestion phase (500-800 ag/1
blood alcohol level)
b) Bays 7-9, ethanol withdrawal phase
c) Days 10-12, ethanol withdrawal
phase
d) Days 18-20, ethanol withdrawal
phase
Phenytoin dose, 300 mg IV and 300 ng
oral (loading dose) followed by 150
mg oral or IV every 12 hr, 20 days.
Alcoholic men with history of
consumption of 470 +or- 184 g/day.
6-30 yr. Steady drinking 1 wk before
admission.
ADULTS; ANTICONVULSANTS; D8UG
THERAPY; DRUGS; ALCOHOLS
a) Bother, at delivery, dose 200 mg
b) Bother, at delivery, dose 200 mg
c) Bother, at delivery, dose 200 mg
d) Infant of a) , 12 hr-S day after
parturition, cord blood level 6,2
ug/ml
e) Infant of b) , 18-36 hr after
parturition, cord blood level 3.9
ug/ml
f) Intant of cl , 21-48 hr after
parturition, cord blood level 6.8
Daily dose during pregnancy with last
dose 4.9-12.5 hr before delivery
Temporary increase 1st day postpartum
d)-f) estimated from graph
Epileptic mothers and their full-term
male infants, Tokyo
Jaundice in two newborns
JAPAN; ADULTS; NEHBORN; CENTRAL
NERVOUS SYSTEfl DISEASES; BLOOD
PLASBA; ANTICONTOLSANTS; DRUGS;
HYPNOTICS; SEDATIVES; PREGNANCY
a) Parent compound (1 subject). 4
and 96 hr after dose. 3.9216 ug/ml
at 1 hr
b) Betabolite,
5- (4-hydroxyphenylJ -5-phenylhydantoin
(II). 10 and 48 br after dose.
0.0318 ug/ml at 1 hr
c) Betabolite, glucuronide of II. 8
and 96 hr after dose. 0.7236 ug/ml
at 1 hr
d) Same as a), second study (1
subject) . 6 and 96 hr after dose.
2.1200 ug/ml at 1 hr
e) Same as b) , 10 and 72 hr after
dose. 0.0484 ug/ml at 1 hr
f) Same as c} , 10 and 96 hr after
dose. 0.5095 ug/ml at 1 hr
Dose 250 mg
Healthy 25 and 36 yr old
BLOOD PLASBA; SALIVA; AHTIAHKHITHBIC
AGENTS; A NTICONVDLSASTS; DRUGS;
SETJBOLITES
REFERENCE
Sandor, p.
Sellers, E.B.
Dumbrell, B.
Khouw, V.
1981
Clinical Pharmacology
and Therapeutics
30(3): 390-397
Ishizaki, T.
Yokocht, K.
chiba, 1C.
Tabuchi, T.
Hagatsuma, T.
1981
Pediatric Pharmacology
1:291-303
Baba, S.
Goromara, T.
Yamazali, K.
Kasuya, Y.
1980
Journal o£
Pharmaceutical Sciences
69(11) : 1300-1307
-------
Bjdantoin, 5,5-diphenyl- (8 CI)
2,
-------
Hydroquifcidine (8 CIV
Cinchonan-9-ol, 10,11-dihydro-6'-liethoxy-. (9S)- (9 CI|
1135-55-8
C20-H26-N2-02
nv 326.HO, HE 169 C
7219
Blood,
plastta
1220
Orioe
EXPOSURE EOOTE
Ingestion
Ingest ion
AHALYTICAl
BETHOD
NUHBER
OT CASES
1
1
RANGE
--
1.8-0 ug/al
Not given
Not given
230 Bg
GENERAL IHFOP.BATION
Hydroguinidine, 6-19.1 hr after 1 g
luoquine (590 mg dihydroquinidine,
410 Bg aBobarbital)
Estimated from graph
16 yr old
Headache, vertigo, sleepiness,
photophobia, sinus tachycardia (125
bpm) at admission 6 hr after dose.
BEIGIDH; ADOLESCENTS; CASE HISTORIES;
ELOOO PLASMA; URINE; ABTIARBHtTHHIC
IGENTS; DPOG ABUSE; DRUGS; LAVAGE
Total hydroquinidine recovered 26 hr
after 1 g Aaoguine (590 ag
dibrdroquioidine, 410 mq aaobarbital)
154 ng recovered at 6 hr
Furoseaide given, IV, to increase
urine output
16 yr old
Headache, vertigo, sleepiness,
photophobia, sinus tachycardia (125
bpm) at adnission 6 hr after dose.
EE1GIOB; ADOLESCEHTS; CASE HISTORIES:
BICOD PLASBA; DEINE; AHTIARBHYTHBIC
AGENTS; DRUG ABUSE; DRUGS; LAVAGE
Lesne, fl.
Devos, D.M.
Reynaert, fl.
1961
Clinical Toxicology
18 (6): 659-662
Lesne, B.
Devos, D.H.
Reynaert, fl.
1981
Clinical Toxicology
18(6):659-662
OJ
Iiidazo(2, 1-b) thiazole, 2, 3, 5,6-tetrabydro-6-phenyl, (S)-
14769-73-4
C11-H12-B2-S
B« 204.31, BP 87-89 C
TISSOE
7221
Blood,
plasaa
i
EXPOSURE POUTE
Ingestion
ANALYTICAL
8ETHOD
GC
_.
KUHBEB .
OE CASES
1
RANGE
_.
0.45-0.02 ug/ll
BEAN
GENERAL INFOBHATIOH
4 and 24 hr after 150 ig, orally.
ANTHELBINTIC; BLOOD PLASBA; DRUG
THERAPY; DRUGS; MEASUREMENT BETHODS;
BELGIUH
BEFE HENCE
Hoestenborghs, R.
Nicliielsen, L.
Heykants, J.
1981
Journal of
ChcOBAtogcaphy
224:25-32
-------
Imiilazole-1-etharol, alpha-(iethoiy»ethyl)-2-nitro- (8 CI)
IH-Inidazole-l-ethanol, alpha-(rethoxymethyl)-2-nitro- (9 CI)
13551-87-6
C7-H11-N3-04
US 201.11
TISSUE
7222
Blood,
plasma
7223
Mammary
gland
EXPOSURE ROUTE
Inqestion
Ingestion
ANALYTICAL
BETHOD
HPLC
HPLC
NOBBED
OF CASES
a) 10
b| 1
1
BINGE
a) 36-8 ug/ml
b) 1-143 ug/ml
3-42 119/9
HEAD
a) Hot given
b) Not applicable
Not applicable
GENERAL INFOBHATICN
_
a) Measurements at 2 hr and 24 hr
after 1 gm/sq m. Initial measurement
25 ng/ml at 30 min
b) 30 min and 3 hr after 1 q/sq m.
Final aeasurenent 43 ug/ll at 4.2 hr
Nornalized doses. Estinated from
graph
Patients »ith carcinoia or lelanoiia.
sootrs; cjscisoaas; BEIISOBAS; BIOOD
PtASKAj CEEEBEOSPIKAt FLUID; (IABBABY
GIABDS; DPUQ THERAPY; DRUGS;
COBPARATIVE EV At UAT ION S ; C HEHOTHERAPT
1 and 1.3 hr after normalized dose of
1 g/sq m
Estimated from graph. Biopsies of
tumor
Patient vith breast carcincia
ADULTS; CAECINOBAS; BELANOBAS; BLOOD
PLASBA; CEE6BEOSPINAL FLUID; BAB1ARI
GLANDS; DRUS THEEAPT; DRUGS;
COMPARATIVE EVALUATIONS; CHEBOTHERAPY
EEFEREBCE
Dische, s.
Saunders, B.I.
Eiley. P.J.
HaucX, J.
Bennett. H. a.
Stratford, B.E.L.
Hinchinton, A.I.
1981
British Journal of
Cancer «3:3
-------
Indole, 3-(2-iaimethylaBinc) ethyl) - (8 CI)
1H-Inaole-3-ethana»ine, N,S-dimethyl- (9 CI)
61-50-7
C12-H16-N2
HV 188.26, HP 44.6-46.8 C
TISSOE
7225
Elood
7226
Orine
EXPOSURE R00TE
Injection
Injection
ANAIYTICAL
METHOD
GC/HS
GC/HS
NOB BEE
OF CASES
11
7
RANGE
..
98-1 n Kg at 50 C, 26.78 mm H? at 90 C
TISSDE | ETPOSOBE EOOTE
|
7227
serum
Ingestion
ANALYTICAL
BETHOD
Chen
HOB BEE
OF CASES
a) 3
c) 3
d> 1
BANGE
a) 100-15.7 ug/100 Bl
c) 92. 1-19.9 ug/100 Bl
d) 65.2-133 ug/100 »1
BEAN
a) Not given
c) Not given
d) Hot given
GEBEBAL INFOBIfATION
a) 2 and 24 hr after 5 »1 iodinated
bound I. Initial level 5.95 ug/100
Bl
b) 1 and 24 hr after 2 iodinated
glycerol tablets, 30 Bg organically
bound I. Initial level 2.4 ug/100 «1
c) 4 and 24 hr after 20 drcps of
iodinatea glycerol in aqueous
solution, 25 Bg organically bound I.
Initial level 3.3 ag/100 Bl
d) 4 and 56 hr following repeated
therapeutic doses of iodinated
glycerol solution, 25 Bg organically
bound I, 4 I/day. Initial level 4.9
ug/100 Bl, reached again 36 hr after
treataent discontinued on 7th day
Bange of Beans, serus 12
Thyroxine I varied within normal
range
Healthy subjects
THYROXINE: BLOOD SEEOB; DBOG TBEBAPT;
DBOGS; IODISE; HALOGENS
REFERENCE
HeBoitin, B.O.
1974
Journal of
Pharaaceutical Sciences
63(8) : 1323-1325
OJ
^J
00
-------
Iron
71439-89-6
te
Atw 55.8H7, HP 1535 C (pure), 1000-1300 C (cast). 1500 C (vcought) , 1300 C (steel), BP 3000 C, VP 1 » Hq at 1787 C, 10 mm Hg at 2010 C
TISSUE
7228
Blood
7229
7230
Blood
7231
plasma
ETPOSOFF. RODTE
Ingest ion
I n g es t io n
Inqestion
Inqestlon
ANALYTICAL
METHOD
Radiometry
Radiometry
Radiometry
AAS
It OH BEE
OF CASES
32
27
37
a) 25
b) 25
C) 25
RANGE
a) 5.8-18.3% of dose
b) 1.2-3.4% of dose
c) 18.2-10.9% of dose
d) 2.4-4.3% of dose
Geometric
a) 1.2-31.3* of dose
b) 3.1-28.5% of dose
c) 1.7- 24.44 of dose
e) 0.8-4.7* of dose
f) 0.2-3.3% of dose
g) 0.3-25. OX of dose
M 0.6-17.2% of dose
a) Hot gi en
c) Hot gi en
d) Not 91 en
e) tiot gi en
g) Sot gi en
h) Not gi en
a) Not given
b) Mot given
c) Not given
BEAN
a) Not given
b) Not given
c) Not given
d) Not given
a) 3. 8% of dose
b) 9.6% of dose
c) 5.5% of dose
e) 2,3% of dose
f) 1.4% of dose
g) 4. 1% of dose
Q) 2.0% of dose
Geometric
a) 0.33 + or- O.G5X of
b) 0.51 *or- 0. 11% of
dos
c) .01 +oc- 0.35S of
d) .36 +or- 0.50X of
dos
e) .37 +or- 0.32* of
dos
f) .91 +or- 0.63% of
dos
g) .86 +or- 0.37% ot
dos
h) .86 +or- 0.43X of
dos
a) 104 tig/100 mi
b) 101 ug/100 ml
c) 92 ug/100 ml
GENERAL INFORMATION
a) Standard meal, 4.1 »g Fe
b) Semisynthetic aeal, 4. 1 mg Fe
sulfate
d) Semisynthetic meal with 25-100 gf
fceef
Range of means
Healthy 18-30 yr olds
B100D; IBON; METALS ; DIETS; FOODS
a) Senisynthetic aeal (4.1 *g Fe){13
subjects)
b) As in a) but no protein (13
c) As in a) but no carbohydrate (13
subjects)
d) AS in a) but no fat (13 sub-Jects)
e} Seaisynthetic aeal (4.1 >g Fe)(14
subjects)
f) As in e) but double protein (14
subjects)
g) As in e) but double carbohydrate
(14 subjects)
h) AS in e) but double fat (14
subjects)
Healthy 18-36 yr olds
BLOOD; IRON; METALS; DIETS; FOODS
a) Basal food (10.5 mg Fe, includi ng
radioactive tracer) (7 subjects)
b) Basal food (11.8 mg Fe, including
3.4 mg ferrous sulfate added) (7
c) Same as a), plus fruit (7
subjects)
d) Sane as b) , plus fruit (7
subjects)
e) Sane as a), plus meat (7 subjects)
f) Same as b) , plus meat (7 subjects)
g) Sane as a), plus fruit and meat (8
subjects)
h) Same as b) , plus fruit and meat (3
subjects)
Easal diet, rice, cabbage, collards.
string beans, chili paste, fish sauce
and coconut creaa
Healthy 18-30 yr olds, Thailand
THAILAND; ADULTS ; BLOOD; BODY; IRON;
METALS; DIETS; FOODS
a) 8 mo after 20 ag Zn and 20 mg Fe
per dav
b) 8 mo after 20 mg Fe/day
c) Placebo
6-12 yr olds, Iran
stimulate growth or bone development.
IEAV; CHILDREN; SLOOD PLASMA; IRON;
HETALS; ZINC; DIETS; ROBAL AREAS
REPE PENCE
cook, J.D.
fi onsen, E_B.
1975
Clinical Nutrition
28 (11) -.1289-1295
Sons en, E, R.
Cook, J.D,
1979
Clinical Nutrition
32:804-806
Hallberg, L.
Suwanik, p.
Bjorn-B asmussen, E.
1974
Clinical Nutrition
27(8) :826-836
Ffahloudji, M.
Reinhold, J.G.
Haghshenass, M .
Ronaghy, H. A.
Fox, H.R.S.
Halsted, J.A.
1975
Clinical Nutrition
(NEXT PAGE)
-------
Iron
7139-89-6
Fe
AtS 55.8*7,
IIP 1535 C (pure), 1000-1300 C (cast), 1500 C (Brought) , 1300 C (steel). BP 3000 c, VP 1 mm Hg at 1787 C, 10 mm Hq at 2010 C
(CONTINUED)
TISSUE
Blood,
serum
7233
Blood,
serun
7234
Blood,
serum
7235
Blood,
serun
7236
Body
EXPOSURE BOUTE
nges
Ingestion
Ingestion
Ingestion
ANALYTICAL
flETHOD
Radiometry
___.
NUHBE8
OF CASES
b) DO
c) 51
a) 10
b) 20
c) 20
247
2
37
RANGE
.
b) Not given
c) Hot given
a) 74-105 ug/100 ml
b) 73-109 ug/100 ml
c) 33-113 ug/100 .1
a) 130-50 ug/100 .1
b) 110-60 ug/100 ml
4750-8000 u.ol/1
20. 0-28. 8X of dose
BEAU
.
b) 107 *or- 31 ug/dl
c) 118 tor- 47 Ui/ai
a) 90 ug/100 ml
b) 92 ug/100 ml
c) 96 ug/100 ml
a) Hot given
b) not given
Not given
Not given
GEBERAL INFOHHATIOH
b) Without supplements
c) Combined a) and b)
•lean age 52.9 +or- t5. 3 yr.
vegetarians 19 *cr- 17 yr.
ADULTS; BLOOD SEE CJM ; HAIB;
HECOGLCBINS; IRON; ZINC; DIETS
a) Controls, non- nutrient supplement
plus lactose containing placebo
capsule
t) High protein-vitamin liquid
supplement plus Mineral capsule (100
ng Fe as ferrous funarate) 6 days/irk
in b) plus 40 mg Zn as carbonate 6
days/wk)
Range of means over 20 months
No supplement during 4 no summer
vacation
Significantly increased fit, wt, and
tone ages in boys receiving 3n during
final 12 no of supplementation.
despite subnormal Zn levels in plasma
throughout study
Serum Fe rose gradually during study.
but rise in b) and c) (iron
supplevented) did not exceed that of
a)
13 yr old, prepubertal, village
schoolboys, southern Iran
IRJH; ADOLESCENTS: SOTRITIOHAL
DEFICIENCIES; BLOOD PLASHA; BLOOD
SEEOB; EEITBEOCYTES; CJICIOB; IEON;
EHOSPHORUS; ZINC; DIETS
a) Infant formula fortified uith 1.2
ig/1
b| Infant formula fortified with 9.4
mg/1
age 6 mo, estimated from graph
(expressed as ug»)
Healthy infants, birth vt >2. 5 kg.
New South wales
AOSTBALIA; IHFAHTS; BLOOD SBEUB ;
IROH; HETALS: DIETS
Peaks, immediately after 1 or 2 g
68 and 76 yr old anemics
BLOOD SESOfl; DRUG THERAPY; DRUGS;
IEON; ItETALS; ANEMIA
3.7 mg Fe as ferrous sulfate with 30
mg ascorbic acid, daily for 4 days
Healthy 18-30 yr olds, Thailand
THAILAND; ADULTS; BLOOD; B CDT ; IRON;
BKALS; DIETS; FOODS
REFEEENCE
Gibson, R.S.
Sabry, J.H.
1981
clinical Nutrition
34:1042-1048
Konaghy, H.A.
Reinhold, J.G.
flahloudji, ».
Ghavami, P.
Spivey Fox, M.It.
Halsted, J.A.
American Journal o£
Clinical Nutrition
27(2) : 112-121
Lamii, A.T.
Lovric, T.A.
Hemphill, U.S.
1915
Australia 1 (14) : 441-443
Blunden, R.H.
Lloyd, J.V.
Rudzki, Z.
Kimber, B.J.
1981
Annals of clinical
Biochemistry 18:215-217
Hallberg, L.
Garby, L.
SuuaniK, H.
B jorn-Ras«ussen, E.
1974
American Journal of
Clinical nutrition
27 (8): 826-836
U)
00
o
-------
Isonipecotic acid, l-nethyl-4-pbenyl-, ethyl ester (8 CI)
«-Piperidinecarboxylic acid, 1-«ethyl-4-phenyl-, ethyl ester (9 CI)
?7-42-1
C15-H21-H-02
»W 247.35, HP 186-189 C
TISSUE
7237
fluid
7236
Blood
7239
Blood
7210
Blood,
plasma
EXPOSURE BOOTE
Injection
Injection
Injection
ANALYTICAL
HETHOD
GC
GC
GC
» or BEE
OF CASES
a) 3
b| 2
c) 2
d> 5
e) 2
g) 1
h) 1
i) 3
1) 1
k) 2
D 2
a) 9
b| 9
c) 9
t
a) 5
b) 1
c) 1
41 3
e) 2
f) 2
11 5
*0 2
1) 3
3) 7
k) 1
1) 3
m) 1
n) 2
o) 2
RANGE
a) 0.01-0.02 ug/ml
b) Not applicable
c) 0.05-0.07 U9/«l
d) 0.01-0.13 ug/iil
e) 0.03-0.05 ug/ml
g) 0.01-0.09 ug/nl
h) Hot applicable
i| 0.02-0.09 ug/il
j) Not applicable
k) 0.05-0.07 ug/ml
1) 0.03-0.07 ug/ml
a) 0.20-0.514 ug/ml
b| 0.22-0.59 ug/ml
c) 0.27-0.70 ug/ml
Hot applicable
a) 0.11-0.37 ug/ml
b) Not applicable
c) Sot applicable
d) 0. 14-0.32 ug/«l
e) 0. 11-0. 13 ug/ml
f) 0.13-0. 69 ug/ml
g) 0. 11-0.19 ug/ml
h) 0. 11-0.38 ug/ml
i) 0. 13-0.23 ug/ml
j) 0.06-0.37 ug/ml
k) Hat applicable
1) 0. 12-0.22 ug/ml
m) Not applicable
n) Not applicable
o) 0.07-0. 13 ug/ml
DEAN
a) Not given
b) 0.02 ug/ml
c) Not given
d) Not given
e) Not given
g) Not given
h) 0.02 ug/ml
i) Not given
j) 0.01 ug/ml
k) Not given
1) Not given
a) 0.11 tor- 0. 17
ug/ml
b) 0.42 tor- 0. 17
ug/ml
c) 0.46 tor- 0. 13
ug/ml
0.30 mg/100 Hi
a) Not given
b) 0.28 ug/al
c) 0.27 ug/ml
d) Not given
e) Not given
f) Mot given
g; Not given
hi Not given
i* Not given
:)) Not given
k) 0. 16 ug/Bl
1) Not given
m) 0. 11 ug/nl
n) 0. 12 ug/Dl
o) Not given
GBNEBAL IHFOE BUTTON
a) 30 nin
b) 35 uin
c) 40 »in
d) 45 min
e) 50 Bin
g) 60 min
h) 70 min
M 75 min
j) 100 »in
k) 120 min
1) 155 tin
limes after 100 lg IB. Not detected
at 15-25 min. Levels in blood plasma
also measured.
Women undergoing abortions at 16-20
wk of pregnancy, NY
NEB VOEK; 1SNIOTIC FLUID; BLOOD
PLASH4; JNJLGESICS; DSOGS; PSEGmKCY
a) Severe pain present
b) Moderate paiu present
c) Effective analgesic levels
Dose 75 or 100 ng at maximum of once
every 1.5 hr
Range of Beans
postoperative patients, ages 25-63
yr, «t 65-93 kg, Australia
ADULTS; BLOOD; ANALGESICS; DRUGS;
JDSTRALI*
Crug induced fatality. Ethanol, 0.10
g/100 ml, also found.
Autopsy, 1975-76, Los Angeles County,
CA
CALIFORNIA; AUTOPSIES; CASE
HISTOBIES; BLOOD; DRUG ABUSE; DRUGS;
FORENSIC flEDICINE; ALCOHOLS
a) 15 min
b) 20 min
c) 25 min
d) 30 min
e) 35 min
f) 40 nin
g) 45 min
h) 50 min
i) 55 iiin
j) 60 min
k) 70 min
1) 75 min
) 100 min
) 120 min
) 155 mm
imes after 100 mg IH. Levels in
nniotic fluid also measured. Plasma
nd amniotic fluid eguilibrium
eachefl at 120-155 min
Hcnen undergoing abortions at 16-20
wk of pregnancy, NY
BEH YORK; ASNIOTIC FLUID; BLOOD
PLAS1A; ANALGESICS; DPDGS; SEDATIVES;
PREGNANCY
BEFERENCE
S?eto, H.H.
Zervoudakis, I. A.
Cederqvist, L. X..
Inturrisl, C.E.
1978
Gynecology 52(1): 59-62
Austin, K-L.
Stapleton, J. v.
Bather, L.E.
1980
Anesthesiology
53(6) :160-466
Nakamura, G.R.
iloguchi, T. T.
Griesemer, E. C.
1979
Journal of Analytical
Toxicology 3:137-142
Szeto, H.H.
Zervoudakis, I. A.
Cedergvist, L. L.
Inturrisi, C.E.
1978
Obstetrics and
Gynecology 52(11:59-62
U)
00
(NEXT PAGE)
-------
Isonipecotic acid, l-«ethy1-U-pbenyl-, ethyl ester (8 CI)
U-Piperidinecarboiylic acid, 1->ethyl-U-phenyl-, ethyl ester (9 CI)
S1-H2-1
C15-H21-H-02
BB 217.35, HP 186-189 c
(CONTINUED)
7211
Blood,
serun
72H2
Blood,
serum
72<43
Orine
EXPOSURE ROUTE
Infection
Infection
Injection
INiLYTICAL
BETHOD
NOflBEB
07 C»SBS
a) 5
b) 5
a) 12
b) 12
10
BADGE
a) 0. 1K-0.02 ug/nl
b) 0.16-0.01 ug/ul
_.
a) 0.131-0.03 ug/»l
b) 0. 127-0.03 ug/Bl
a) Mot given
Not given
BEAN
a) Not given
b) Not given
a) Not giveu
b) Not given
a) 31. 7X
b) 43.5*
GEWEBAL IHFORHATION
a) 60 and 430 sin after 26 ng/cu n.
Initial measurement 0.03 ug/ml at 15
• in
tl 6Q and *t80 min after 26 mg/cu •
plus 30 ng/cu • chlorpronazine.
Tnitial neasuresent 0.03 ug/»l at 15
nin
Bangs of means
Estimated froa graph
Healthy 2t-30 yr olds.
Harked lethargy and greater
depression of mean systolic and
diastolic pressures when drugs given
together.
8DULTS; BLOOD SEBOH; OEISE;
AHALGESICS; DBOG IHTERACTIOH; DRUGS ;
JLOOD PRESSOBE
a) 1 and 8 br after 50 mg I« (test
product) as hydrochloride. Initial
neasurenent 0.110 ug/ml at 0.5 hr
b) 1 and 8 br after 50 ng in
(reference product) . Initial
neasurement 0.105 ug/nl at 0.5 hr
Ho significant differences feetveen a)
and b)
Range of Beans, estimated from graph
Healthy 21-30 yr olds, wt 110-185 Ib
Dizziness, dry nouth, light
headed ness
B1000 SEROH; ANALGESICS; DBOGS
a) 24 hr emulative output* including
•etabolites after 26 »g/cu • dose
b) 2t| hr emulative output, including
aetabolites, after 26 ig/cu a dose
plus 30 ng/cu a chlorproaazine
Healthy 21-30 yr olds
Barked lethargy and greater
diastolic pressures when drugs given
together.
ADOLTS; BLOOD SEEOS ; ORIME ;
ANALGESICS; DRUG IN TER ACTION; DRUGS ;
BLOOD PBESS0HE
PEFERENC2
Staabaugh, J.B .
wainer, I.H.
1981
Journal of Clinical
Pharmacology 21:140-146
Staabaugh, J. E .
Hainer, i.w.
1974
Journal of Clinical
Pharmacology
14(10) :552-559
Stanbaugh, J.E.
Wainer, I.H.
1981
Journal of Clinical
Pharmacology 21:140-146
00
K3
-------
Isopropyl alcohol (8 CI)
2-Propanol (9 CI)
67-63-0
C3-B8-0
BS 60.09, HP -88.5 to -69.5 C,BP 80.3 C, VP 10 II Bg at 2.4 C
TISSUE
7214
EXPOSURE ROUTE
Ingest ion
ANALYTICAL
HETHOD
GC
_
NOB BEE
OF CASES
1
RANGE
Not applicable
.._.
HE AH
1.65 q/1
GENERAL IHFORSATIOS
Unknown dose of ethanol-isopropanol
45 yr old
Coma, respiratory distress
BLCOD SERUH; DBUG ABUSE; DRUGS;
ALCOHOLS
_
REFERENCE
vasiliades, j.
Pollock, J.
Bobinson, c.A.
1978
Clinical Cheiistry
2tt(2):383-385
L-Proline, 1- (3-mercapto-2-methyl-l-cxopropyl) -, (S) -
62571-86-2
C9-H15-N-03-S
BB 217.31
TISSUE
7215
7246
EXPOSURE ROUTE
Ingestion
Ingestion
ANALYTICAL
(1ETHOD
HPLC
GC/MS
NOBBEH
OF CASES
12
12
RANGE
a) Not given
b) Not given
c) Not given
d) Not given
e) Hot given
f) Not given
a) 400-450 ng/ml
b) Not given
c) 500-6 ng/ml
(NEXT
HEAN
a) 364 +or- 64 ng/mi
b) 342 +or- 76 ng/ml
c) 80 ng/ml
d) 210 ng/»l
e) 0 ng/ml
f) 40 ng/ml
a) Not given
b) 7 ng/ml
c) Not given
PAC.E)
GENERAL INJORBATION
a) 1 hr, 5 normal sub-Jects
b) 1 hr, 7 patients with chronic
renal failure (CRF)
c) 2 hr, group a)
d) 2 hr, group b)
e) tt hr, group a)
f) it hr, group b)
Times after 50 mg, oral
c)-f) estimated from graph
Significantly prolonged retention in
urinary excretion.
Normal subjects, mean age 37.3 yr, wt
66.7 kg. Patients with chronic renal
failure caused by glomerulonephritis.
mean age 47.4 yr, «t 55.6 kg
ADULTS; KIOSE1T DISEASES; BLOOD;
URINE; AN1IHYPERTEHSIVE AGENTS;
DRUGS; BETABOLISB; BETABOLITES
a) 1 hr after doses 1,4 and 7
b) About 8 hr after dose 6
c) 0.5 and 8 hr after dose 7
Range of means, estimated from graph
100 mg 3x/day (7 doses)
Mean peak level 713.1 ng/ml at mean
time of 1.1 hr. Bean AUC 1067.2 ng
hr/ml (0-8 hr)
Significantly lower levels in milk
Healthy 21-35 yr olds, wt 50-86 kg
ADULTS; 3LOOD; MILK; ASTTH1PE1TENSIVE
AGENTS: DBUG THERAPY; DRUGS;
LACTATION
REFERENCE
_
Onoyama , K.
Hirakata, H.
Iseki, K.
Fujimi, S.
Omae, T.
Kobayashi, B.
Kawahara, y.
1981
Hypertension
3(4) :456-459
Devlin, E.G.
Fleiss, P. a.
1981
Journal of clinical
Pharmacology 21:110-113
UJ
00
U)
-------
L-Proline, 1-(3-aercapto-2-methyl-1 -oxopropyl)-, (S)-
€2'=71-86-2
C9-H15-N-03-S
BS 217.31
(COS1IHIJED)
TISSOE
72H7
Bilk
7248
Urine
EXPOSDPE BODTE
luges tion
Ingestion
ANALYTICAL
SBTHOD
GC/BS
HPIC
NUHBBB
OF CASES
11
a| 5
t>> 7
BANGS
a) 1.8-3.0 ng/ml
b) Hot given
c) 2.2-5.5 Eg/ml
a) Hat given
b) Hot given
.
a) Hot given
b) 2.0 ng/ml
c) Hot given
29 mg
8 .9
GENEBAL INFOBBATION
a) 1 hr after doses 1, 4, 7
b) About 8 hr after dose 6
c) 0.5 and 1 hr after dose 7. Final
measuresent 3.0 ng/ml at 8 hr
Range of means, estimated froa graph
100 mg 3z/3aj (7 doses). Bean peak
level 4.7 ng/ml at Bean time of 3.8
hr. Bean AOC 22.9 ng hr/ml
Levels significantly lower than those
in blood
Healthy 21-35 yr olds, irt 50-86 kg
SDDLTS; BLOOD; BILK! SNTIHYPEPTENSI7E
SCENTS; DRUG THEBAPY; DRUGS;
LACTATION
a) Hornal subjects
b) Patients with chronic renal
failure (CBF)
Cumulative excretion 6 hr after 50
ng, oral
Estimated from graph
significant decrease in excretion by
CEF patient important factor in
retention of drug.
Nornal subjects, mean age 37.3 yr, vt
66.7 kg. patients with chronic renal
failure caused by glonerulonephritis,
•ean age 47.4 yr, wt 55.6 kg
ADULTS; KIDNBI DISEASES; BLOOD;
OEINE; 6HTIBYPEETEBSIVE AGENTS;
DEOGS; BETIBOLISB; BETJBOLITES
BEFEBENCE
Devlin, E.G.
Fleiss, P.H.
1981
Journal of Clinical
Pharmacology 21:110-113
Onoyama, K.
Hirakata, K.
Iseki, K.
Fujimi, S.
Omae, T.
Kobayashi, B.
Kavahara, T.
1981
Hypertension
3 (1) :«56-«59
00
Leurocristine (8 CI)
Vincaleukoblastine, 22-oxo- (9 CI)
57-22-7
C"46-H56-H«-010
B8 82".9t, BP 218-220 C
72U9
Elood,
serxliD
7250
Cerebrosp
inal
fluid
EXPOSUHE BOOTS
Injection
Injection
HALYTIC4L
BETHOD
NOB BEE
OF CASES
a) 1
b) 1
a) 1
b) 1
3 1
BANGE
a) 8. 91 10 (E-7) -2X10 (E-9)
b)
1. 91 10 (E-7)- 1.5X10 (E-9) fl
a)
7110 (E- 10)-1.2X10 (E-9) a
b) 9.5I10(E-10)H
c) 2. 6110 (E-9) B
flEAS
a) Not applicable
b) Hot applicable
a) Hot given
b) Not given
c) Hot given
GENEEAL INFOBSSTICK
a) 8 min and 24 hr after 2 mg
b) 5 min and 21 hr after 2 «q
Four other patients' spot samples at
2.0-1.0 hr ranged from 5.0TlO(E-9)fl
to 2.8110 (E-8) 9
Patients with lymphoma or leukemia
CARCINOBAS; LEDKEBIl; BLOOD SEEOH;
CEBEBEOSPIHAL FLUID; DRUG TBEEAPT;
DBUGS; CHEBOTBEEAPT
a) 30 min and 6 hr after 2 mg
b) 30 min .after 2 mg
c) 3 hr after 2 mg
&t other time periods neasureneats
fell below detectible limits
Patients with lymrhoma or leukemia
CAECIHOBAS; LEOKEHII; BLOOD SEBBB;
CEBEBBOSPIHAL FLUID; DBOS THEEAPT;
DBUGS; CHEBOTHEBAPt
Jackson, D.V., Jr.
Sethi, V. S.
Spurr, C.L.
BcKhorter, J.N.
1981
Cancer Eesearch
41:1466-68
Jackson, D.Y., jr.
Sethi, v.s.
Spurr, C.L.
Hc»horter, J.«.
1981
Cancer Eesearch
41:1466-68
-------
lithiun
7U39-93-2
II
AtW 6.9H1, MP 180.5U C, BP 1336 C, VP 1 •» Hg at 723 C, 10 II Bg at 890 C
TISSUE
7251
Blood ,
serum
72S2
Blood,
serum
EXPOSURE ROUTE
Ingestion
ANALYTICAL
METHOD
AAS
HHHBEE
OF C1SES
16
60
BASSE
a) 0.65-0. U8 «eq/l
b) 0.78-0.50 meg/1
.
a) < 0.6 naol/1
b) 0.6-0.8 niBOl/1
c) >0.8 mnol/1
HEAD
a) Not given
b) Not given
a) Not given
b) Not given
c) Not given
GENERAL INFORHATIOH
a) He an daily range (12 Pfl and 8 PH)
for seven day study. 450 »g slow
release tablet given at B AS, and 8
PH. 0.55 meq/1 average at 8 AH
before first dose
b) Mean daily range for 300 mg
and 8 PR during 7 day study. Peak
level occurred at 10 AH, mini BUB
before 8 AS. Secondary peaks (0.7
and 0,65 neg/1) at 1 PM and 10 Pfl,
about 2 hr after 2nd and 3rd doses
Esti nated from graph
Healthy 19-30 yr olds
BLOOD SERUM; DRUGS; COMPARATIVE
EVALUATIONS; LITHIUM
a) 33. 3* of patients
b) 33.3* of patients
c) 32* of patients
receiving prophylactic Li therapy
Australia
AUSTRALIA; NEBVOUS SYSTEM DISEASES;
BLOOD SERUH; AHTIDEPFESSIVE AGEHTS;
DRUG THERAPY; DRUGS
REFERENCE
Caldvell, B.C.
HestlaJte, W.J.
Schriver, R.c.
Bunbier, E.E.
1981
Journal of Clinical
Cor, J.
B vans, L.
Siskind, 7.
Medical Journal of
Australia 1 (13): 622
Co
, , , .,,.. — . „,...,._. , ^^j
Ln
ethanesulfonanilide, 4'-{l-hydroxy-2-(isopropylaBino) ethyl)- (8 CI)
ethanesulf onanlde, »-(«-(1-hydroiy-2-( (1-nethylethyl) amino) eth7l) phenyl) - (9 CII
930-20-9
12-H20-N2-03-S
272.36
TISSUE
7253
Blood,
plasma
7254
Blood,
plasma
EXPOSURE ROUTE
Ingestion
Ingestion
AS1LTTICSL
METHOD
HPLC
» on DEE
OF CASES
5
a) 6
b) 6
RANGE
0. 18-2.65 ug/ml
a) 970-160 ng/Dil
b) 1210-160 ng/nl
(HEX!
KEAH
Not given
a) Hot given
b) Not given
PAGE)
GEHEHAI. INFORMATION
0.25 and 3 br after 320 ng. Final
neasureaent, 0.27 ug/ml at 30 hr
Range of veans
Healthy 21-30 yr olds. Bean ut 63 kg
BLOOD PLASMA: OBIME; A STIHYPEBTENSIVE
JGEKTS; DBOSS
a) 2 and 10 hr after 160 ng dose.
Initial Beasurevent 700 ng/al at 1 hr
b) 2 and 10 hr after 160 Bq dose.
Initial Beasureaent 690 ng/Bl at 1
hr. Blood alcohol level of 0,0-150
Bg/100 Bl (lean 67.6 *or- 55.2 Bg/100
• 1)
Range of Beans
Healthy students, aean age 22.9 yc.
mean wt 63.9 kg.
ADULTS; BLOOD PLASMA: ASTI ABBHY. 1H>!IC
SGEHTS; DROS IHTEEACTIOM; DHOGS;
A1COHCLS
REFERENCE
Fourtillan, J. B.
Lefebvre, M.A.
Courtois, p.
Saux, rt.C.
1981
Therapie 36:»57-H63
Sotanieai, E.A.
Anttila. n.
Rautio, A.
stengard, J.
Saukko, P.
Jarvensivu, p.
1981
Clinical Pharaacology
and Therapeatics
29(6) : 705-7 10
-------
Nethanesulfonanilide, »'-(l-hydroxy-2-(isopropylamino) ethyl) - (8 CI)
Rethanesulfonamide, N- (it- (1-hydroiy-2- ((1-nethyletbyl) amino) ethyl) phenyl) - (9 CI)
3930-20-9
C12-H20-N2-C3-S
BB 272. 36
(COUTISOfB)
TISSUE
7255
Blood,
plasma
7256
Urine
1 _ ...
EXPOSURE EOUTE
Ingestion
Ingestion
ANALYTICAL
HETHOD
fluorometry
HPLC
NOBBED
OF CASES
a) 5
b) 5
c) 5
d) 5
5
RANGE
a) 0.7-0.1 ug/ml
b) 0.8-0.06 ug/ml
c) 1.5-0.2 ug/ml
d) 4-0.4 ug/ml
3.8-58.9* of dose
BE AS
a) Not given
fa) Not given
c) Not given
d) Not given
Not given
GENERAL INFOP NATION
a) 2 and 148 hr after 50 »g . Initial
measurement 0.15 ug/ml at 1 hr
b) 2 and 48 hr after 100 »g. Initial
neasurement 0.5 uq/ml at 1 hr
c) 4 and 48 hr after 200 mg. Initial
measurement 0.8 uq/ml at 1 hr
d) 2 and 48 hr after 400 mg. Initial
measurement 2 ug/ol at 1 hr
Pange of means, estimated from graph
Healthy 18-33 yr olds
Duration of cardiac beta blacking
activity determined by elittination
half life and dose.
IDULTS; BLOOD PL1S1U; DRUGS;
COHPABSTIVE EVALUATIONS
2 and 48 hr after 320 mq
Cumulative output. Range of means
Healthy 21-30 yr olds, mean wt 63 kg
BICOD PLASMA; URISE; ANTIB JPERTENSIVE
JGENTS; DRUGS
REFERENCE
Harron, D.K.G
Balnave, K.
Kinney, C.D-
Wilson, E.
Russell, C.J.
Shanks, R.s.
1981
Clinical Pharmacology
and Therapeutics
29 (3):295-302
Fourtillan, J.B.
lefebvre, 11. A.
Courtois, P.
Saux, n.C.
1981
Therapie 36:457-463
1
I
Hcrphinan-3.6alpha-aiol, 7,8-diaehyaro-4,Salpha-epoxy-17-methyl- (8 CI)
Morphinan-3,6-dlol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha) - (9 CI)
57-27-2
C17-H19-N-03
n« 285.33, tip 197 C (metastable phase), 254 C (decomp)
00
TISSDE
7257
Bile
7258
Bile
EXPOSURE ROUTE
Injection
Inhalation
ANALYTICAL
BET HOD
BIA
Hit
GC/BS
NUHBEB
OP CASES
19
6
BANGE
52-5254 ug/»l
3.40-72.42 »g/41
KEAN
621 ug/ml
Sot given
GENEBiL IKFORBATION
19 of 66 cases submitted foe
toxicological analysis, autopsy
material.
New Jersey
NCT JEESEY; AUTOPSIES; BILE; BLOOD;
BSAIH; KIDNEYS; LITER; DRUG ABUSE;
DRUGS; NARCOTICS; FORENSIC 5EDICINB;
HETABOLITES
(NEXT PAGE)
Suspected oc known cocaine overdose
fatalities, autopsy data
18-26 yr olds, Los Angeles County, CA
CALIFORNIA; AUTOPSIES; BILE; BLOOD;
BRIBE: DRUG ABUSE; DRUGS; NARCOTICS;
I FORENSIC BEDICINE; INHALATION
I
Coumbis, R.G.
Kaul, B.
197«
Journal of Forensic
Sciences 19 (2) :307-312
Nakaiura, G.R.
Noguchi, T.T.
1981
Clinical Toxicology
18(8) : 895-905
-------
florphinan-3,6alpha-diol, 7,8-didehydro-&,5alpha-epoxy-17-aethyl- (8 CD
flcrphinan-3.6-ai.ol, 7, 8-aiaehydro-il,5-epoxy-17-«ethyl- (5alpha,6alpha|- (9 CI)
•=7-27-2
C17-B19-N-03
flB 285.33, DP 197 c (netastacle phase), 2S4 C (decoip)
(CONTINUED)
7259
Blooa
7261
Blood
7262
Blood
EXPOSURE ROUTE
Injection
Injection
Inhalation
ANALYTICAL
METHOD
RIA
GC/BS
HIS
GC/BS
NOBBER
OF CASES
Negligible-200 ug/nl
a) Not applicable
b) Sot applicable
0.2 ag/100 «1
814 ug/nl
a) 0. 13 «g/kg
b| 0.33 tig/kg
GEHEBAL IHFORBATION
38 hr after overdose
26 yr old
Asystolic state, without spontaneous
respirations, conatose and
hypotensive.
Henorrhagic bronchopneuaonia.
Centrolobular hepatic necrosis and
renal tubular necrosis.
AUTOPSIES; CASE HISTORIES; BLOOD;
IIVEP; D80G ABUSE; HAFCOTICS;
FOBENSIC BEDICIHE
20 of 66 cases submitted for
toxicological analysis, autopsy
naterial.
New Jersey
NEW JEBSEY; AUTOPSIES; BILE; BLOOD;
IBAIS; HIDSEYS; LIVES; DBBG ABUSE;
DRUGS; NARCOTICS; FORENSIC MEDICINE;
SETABOI.ITES
a) 2100 q fetus. Mother dependent >
4 yr. Codeine not detected
b) 205t g male fetus, deaa at least
3-tt aays pre-delivery. Codeine level
O.OK Bg/kg
Stillborn infants of 20 and 21 yr old
heroin-dependent Bothers
Death frcB intrauterine anoxia and
acute intoxication. ("others had
ingestea or injectea morphine
derivative and/or propoxyphene.
FETUS; INFANTS; BLOOD: BB1IN;
KIDN1TS; LIVEB; LONGS; ANALGESICS;
DPOG ABUSE; DRUGS; NARCOTICS;
BETABCLISB; BETAEOLITES
Stispectea or known cocaine overdose
fatalities, autopsy data
22-26 yr olds, Los Angeles County, CA
CALIFORNIA; AUTOPSIES; BILE; BLOOD;
URINE; TBITG ABUSE; DRUGS; NAPCOTICS;
FOBENSIC MEDICINE; INHALATION
(NEXT PAGE)
REFERENCE
wisely, D.v.
NakaBura, G.R.
1980
Journal of Forensic
Sciences 25(2) :366-368
coumbis, R.G.
Kaul, B.
19714
Journal of Forensic
Sciences 19 (2) :307-J12
Cravey, R.H.
Reed, D.
1981
Clinical Toxicology
18(8) :911-91I4
to
CO
Nakamura, G.B.
Noguchi, T.T.
1981
clinical Toxi-ology
18 (8): 895-905
-------
florphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoiy-17-methyl- (8 CI)
Mcrphinan-3,6-diol, 7, 8-didehydro-0.5-epoxy-17-methyl- (Salpia,6alpha|- (9 CI)
57-27-2
C17-H19-N-03
BH 28S.33, HP 197 c (metastable phase), 254 C (decomp)
(CONTINUED)
TISSOE
7263
Blood
72 6 4
Blood,
plasma
7265
Blood,
plasma
EXPOSOBE BOtJTE 1 A81LYTICM
Injection
Injection
BETHOD
Fluorometry
Badionetry
NUMBER
OF CASES
a) 23
b) 27
c) 268
d) 61
e) 69
f) 7»
g) 112
h) 12
12
12
_
BANGE
a) Hot detected-299 ug/dl
b) Sot detected-29 ug/dl
c) Hot detected- 199 ug/dl
d) 1-100* ug/dl
e) 1-99 ug/dl
f) 1-99 ug/dl
g) 1-99 ug/dl
h) 2-31 ug/dl
a) 49-5 nug/iil
b) 160-50 mug/ml
c| 51-4.5 mug/al
d) 180-50 aug/al
a) 55-5 mug/ml
b) 46-4 mug/ml
c) 45-5 mug/ml
d) 43-3 mug/ml
e) 170-50 mug/ml
f) 170-60 mug/Bl
g) 170-50 lug/il
h) 190-70 mug/ml
«EAN
a) Not given
b) Rot given
c) Not given
d) Not given
e) Not given
f) Hot given
*// Mot given
h) Not given
a) Not given
b) Not given
c) Bot given
d) Hot 'given
a) Sot give
b) Not give
c) Not give
d) Sot give
e) Hot give
1) Hot give
g) Not given
h) Not given
GENZEAI. INFORMATION
a) Narcotic addiction deaths, 1974,
23 cases, 6 above 29 ug/dl
b) Homicide deaths, 1974, 27 cases
c) Narcotic addiction deaths, 1975,
268 cases. 33 above 29 ug/dl
d) Deaths involving morphine, 61
cases of c) , 13 above 29 ug/dl
e) Deaths involving morphine and
ethanol, 69 cases of c), 11 above 29
ug/dl
f) Deaths involving morphine and
quinine, 74 cases of c), 12 above 29
ug/ai
g) Deaths involving morphine, ethanol
and guinine, 112 cases of c) , 17
above 29 ug/dl
h) Deaths involving morphine and
diazepan, 12 cases of c) , none above
29 og/31
Bayne county, MI
MICHIGAN; AUTOPSIES; DRIJS ABOSE;
DRUGS; NARCOTICS; PSYCHOTROPIC DPOGS;
SEDATIVES
a) Free morphine. 0.25 and 6 hr after
5.75 mg/sq m (6 subjects)
b) Conjugated morphine. 0.5 and fc hr
after dose as in a) . Initial
measurement 148 lug/ml at 0.25 hr
c) Free morphine (second study) .
0.25 and 6 hr after 5.75 mg/sq m (6
subjects)
d) conjugated morphine. 0.25 and 6
hr after dose as in c)
Bange of means, estimated from graph
Guanethidine (5 or 10 mg/6 hr| had
little effect on plasma levels
Healthy 20-28 yr olds
BICOD PLASKA: DBISE; DEDG
INTERACTION: DROGS; NARCOTICS;
HETABOLITES
a) Free morphine (6 subjects)
b) Free morphine. Dose plus 0.6 g
aspirin/6 hr (same subjects as a))
c) Free morphine (6 subjects)
3) Free morphine. Dose plus 1. 2 g
aspirin/6 hr (same subjects as c) )
e) conjugated morphine (metabolite)
(6 subjects)
f) conjugated morphine. Morphine
dose plus 0.6 g aspirin/6 hr (same
subjects as e) )
g) conjugated morphine {6 subjects)
h) conjugated morphine. Morphine
dose plus 1 .2 g aspirin/6 hr (same
subjects as g) )
Heans (estimated from graph) at 0.25
and 6 hr after 5.75 mg morphine/sq m.
Levels at ti.5 hr for e) , f) and g)
slightly higher than 170 m»g/ml
Significant differences between a)
and b), c) and d) , g) and h)
Healthy 21-28 yr olds
BLOOD PLASMA; OBINE; ASALGESICS; DRUG
INTERACTION; DRDGS; HABCOTICS
REFEBENCE
Monforte, J.R.
1977
Journal of Forensic
Sciences 22 (»| :7 18-724
Brunk. S.F.
Delle, H.
ailson, «.E.
1974c
Journal of clinical
Pharmacology
14(11/12) :581-587
Brunk, S.F.
Delle, «.
Hilson, B.B.
1974b
Clinical pharmacology
and Therapeutics
15(3) : 2 83-290
(HEX! PAGE)
00
00
-------
ncrphinan-3,6alpha-diol, 7,8-didehydro-4fSalpha-epoxy-17-iethyl- (8 CI)
norphinan-3,6-diol, 7,8-didehydro-4.5-epoxy-17-Bethyl- (5alpha,6alpha)- (9 CI)
C17-H19-N-03
BW 285.33, »P 197 C (net as table phase), 254 C (deco»p)
(CONTINUED)
TISSUE
7266
Blood,
plasma
7267
Blood,
secum
7268
Brain
7269
Brain
EXPOSURE EOOTE
Injection
Injection
ANALYTICAL
HETHOD
RIA
RIA
RIA
GC/HS
NUHBER
OP CASES
12
3-1 1
13
2
BANGE
a) 53-5 Bug/ml
b) 48-5 BUg/Bl
c) 160-50 ms/ml
d) 170-50 mug/Hi
a) 0.4-0.02 ug/iil
b) 0.07-0.02 ug/ml
c) 0.025-0.075 ug/nl
Negligo.ble-200 ug/IOOg
a) Not applicable
b) Mot applicable
BEAN
a) Not given
b) Hot given
c) Not given
d) Not given
a) Not given
bj Not given
c) Not given
35 ug/IOOg
a) 0.08 ag/kg
b) 0.08 mg/kg
GENERAL INFORBATION
a) Free norphine. 0.25 and 6 hr
after 5.75 mg/sg B (6 subjects)
b) Sane as a), second stud; (6
subjects)
c) Conjugated morphine (saie study as
a)|. 0.5 and 6 hr after dose. 150
flug/Bl at 0.25 hr
d) Conjugated morphine (sane study as
b) . 0.5 and 6 hr after dose. 150
Bug/ml at 0.25 hr
Pange of Beans estiaated froa graph
Propranolol (20 or 10 Bg/6 hr) had
little effect on levels.
Healthy 21-28 yr olds
BLOOD PLXSflJ; URINE; DRUG
INTERACTION: DBOGS; NARCOTICS;
BETABOLITES
a) Total morphine. Initial
measurement and 4 hr after 10 rng/70
kg, IV
b) Free morphine. Initial
measurement and U hr after 10 mg/70
kg, in
c) conjugated morphine, same study as
t) . 0.0 and 2 hr
Range of means, estimated from graph
Patients >50 yr old had significantly
higher levels during first 5 Bin
23-75 yr old surgical patients
AGE; BLOOD SERU1; DBOG THERAPY;
DRUGS; NARCOTICS
43 of 66 cases submitted for
toxicological analysis, autopsy
material.
New Jersey
NEW JERSEY; AUTOPSIES; BILE; BLOOD;
ERAIN; KIDNEYS; LIVER; DRUG tBtJSE;
DRUGS; NARCOTICS; FORENSIC HEDICINE;
METABOLITES
a) 2100 fetus. ' Bother dependent > 4
yr. Codeine not detected
b) 2054 g male dead at least 3-4 days
pre-delivery. Codeine not detected
Stillbcrn infants of 20 and 21 yr old
heroin-dependent mothers
acute intoxication. Mothers had
ingested or injected morphine
derivative and/or propoxyphene.
FETOS; INFANTS; BLOOD: BRAIN;
KIDNEYS: LI7ER; LUNGS; ANALGESICS;
DRUG ABUSE; DRUGS; NARCOTICS:
HETABCLISn; flETABOLITES
REFERENCE
.
Brunk, s.f.
Delle, n.
Vilson, «.R.
1974a
Clinical Pharaacology
and Therapeutics
16(6): 1039-1044
Berkowitz, B.A.
Sgai, S.H.
yang, J.C.
Heapstead, B.S.
Spector, S.
1975
Clinical Pharmacology
and Therapeutics
17(6) : 629-635
CouBbis, R.G.
Kaul, B.
1974
Sciences 19 (2) :307-312
Cravey, R.H.
Reed, D.
1981
Clinical Toxicology
18 (8) :9 11-914
(NEXT PAGE)
00
-------
florphinan-3,6alpha-diol, 7 ,8-didehydro-4, 5alpha-epo«y- 17-iethyl- (8 CI)
flcrphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-Bethyl- (Salpha ,6alpha) - (9 CI)
57-27-2
C17-H19-N-03
B» 285.33, MP 197 c (»etastable phase), 254 C (decoBp)
(CONTINUED)
TISSUE
7270
Kidney
7271
Kidney
7272
Liver
7273
liver
7274
liver
EXPOSURE ROUTE
Inlection
ANALYTICAL
METHOD
BI»
EIA
GC/MS
6C
Bit
RIA
GC/MS
SOflBEE
OF CASES
29
1
1
»«
2
SINGE
5-225 ug/IOOg
Hot applicable
Hot given
6-200 ug/lOOg
a) Hot applicable
b) Nat applicable
BEAN
93 ug/IOOg
0.21 Bg/kg
0.05 Bg/100 g
72 ag/100g
a) 0. 18 eg/kg
b) 0. 12 B 4
yr, codeine level 0.02 ng/kg.
Stillborn infant o£ 20 yr old
h«ro in-dependent mother
FITHS; ISFANTS; BLOOD; BRAID;
KIDNEYS; IIVEB; LOUGS; A9ALGBSICS;
DRUG ABOSE; DRUGS; NARCOTICS;
BETABOLIS11; METABOLITES
38 hr after overdose
26 yr old
Asystolic state, without spontaneous
hypotensive.
HeBorrhagic bronchopneuaonia.
Centrolobular hepatic necrosis and
renal tubular necrosis.
AUTOPSIES; CASE HISTORIES; BLOOD;
LIVER; DRUG ABUSE; NARCOTICS;
FOREBSIC 8EBICINE
U U of 66 cases submitted for
tcxicological analysis, autopsy
• aterial.
New Jersey
AUTOPSIES; BILE; BLOOD; BRtlN;
KIDNEYS; IIVEB; DHUG ABUSE; DRUGS;
NARCOTICS; FORENSIC MEDICINE;
MSTiBOLITES
2100 g fetus. Mother dependent > 4
yr. Codeine not detected
b) 3614 g fetus dead 4-5 days
pre-delivery.
Stillborn infants of 20 and 21 yr old
heroin-dependent Bothers
acute intoxication. Bothers had
ingested or injected Morphine
derivative and/or propoiypnene.
FETUS; INPASTS; BLOOD; BRAIN;
KIDBEIS; LIVER; LUNGS; ANALGESICS;
DRUG ABUSE; DRUGS: NARCOTICS;
METJBOIISB; BETiBOLITES
REFERENCE
COUBbis, R.G.
Kaul, B.
1974
Sciences 19(21:307-312
Cravey, R.H.
Reed, D.
1981
Clinical Toricology
18(8) -.911-914
Hisely, D.V.
NakaBura, G.R.
1980
Journal of Forensic
Sciences 25(21:366-368
CouBbis, B.C.
Kaul, B.
1974
Sciences 19(21:307-312
Cravey, B.H.
Reed, D.
1981
Clinical Toxicology
18(8):911-914
(NEXT PAGE)
LO
>sD
O
-------
Horphinan-3 ,6alpha-diolr 7 ,8-didehydro-4, 5alpha-epoxy- 17-aethyl- (8 CI)
Horphinan-3,6-diol, 7,8-aidehydro-»,S-epoiy-17-«ethyl- (5alpha,6alpha)- (9 CI)
57-27-2
C17-H19-N-03
!•» 285.33, BP 197 c (netastable phase), 251 c (deco«p)
(COHTIHDED)
TISSUE
7275
Lung
7276
7277
7278
7279
EXPOSURE POOTE
I n jec tion
Injection
In lection
Injection
ANALYTICAL I NOMBEB
METHOD
RIA
GC/flS
RIA
PI A
TLC
GC
OF CASES
1
1
a) 1
bj 1
c) 1
3) 1
e) 1
4
12
BANGE
Mot applicable
a) 7979-80 ug/1
b) 2000-21 ug/1
a) 5.334-7.423 «q
b) 12.407-11.2111 mg
c) 8.775-14.383 mg
d) 26.100-32.792 mg
e) 35.100-37.298 ng
a) 6.60-9.90X of dose
b) 62.97-82.80% of dose
a) 4-11% of dose
b) 5-11% of dose
c) 5-48X of dose
d) 7-50% of dose
SE
HEAN
0.20 «g/kg
a) Hot given
b) Hot given
a) Not given
b) Hot given
c) Hot given
d) Hot given
e) Not given
a) 8.27 +or- 0. 60% of
dose
b) 76.1*9 + or- 2.40X
of dose
SE
a) Not given
b) Not given
c) Hot given
d) Not given
GENERAL INFORMATION
2100 g fetus. aether dependent > U
jr. Codeine level 0.02 mg/kg.
stillborn infant of 20 yr old
heroin- dependent Bother
acute intoxication.
FETUS; INFANTS: SLOOD; BRAIN;
KIDNEYS; LIVER; LUNGS; ANALGESICS;
CBUG ABUSE; DRUGS; HAPCOTICS;
METABOLISH; HETABOLITES
a) 0-72 hr after 10 ng/70 kg, subject
t
b) 0-72 hr after 10 ag/7Q kg, subject
2
Bepresentative data from 12 subjects
expressed as »orphine equivalents.
Volunteers
ORIHE; DRUGS; HYPNOTICS; HARCOTICS;
HEASOREHEHT METHODS
a) 53.3-7H.21f of 10 mg dose
b) 62.0-71-2* of 20 jog dose
c) 29.3-17.9* of 30 mg dose
d) 65. 3-82. OK of 10 mg dose
e) 70.2-71.6' of 50 mg dose
Total cumulative output (nocphine and
after IV dose.
Hospital patients, Japan
HEINE; DRUGS; NARCOTICS; MEASUREMENT
METHODS; JAPAH
a) Free morphine
b) Total , including metabolites
Hean daily output for 7 day period
after stabi lizat ion on 60 mg, as
sulfate, 1 X/day for U vk. Data also
given for individual metabolites
27-1 1 yr old morphine addicts
DPDG ABUSE; DBUGS; NARCOTICS; UBINE;
METABOLITES
a) Free morphine. 0.25 and 24 hr
cumulative output after 5.75 ng/sq m
(6 subjects)
b) Same as a) second study (6
subjects)
c) Same as a) , conjugated morphine
d) Same as b) conjugated morphine
Range of means, estimated from graph
Guanethidine (5 or 10 mg/6 hr) had
little effect on cumulative output
Healthy 20-28 yr olds
BICOD PLASIU; OPINE; DROG
I NTER ACTIO W ; DR D GS ; NA RC OT 1C S ;
METABOLITES
BEFERENCE
Cravey, R .H .
Reed, D.
1981
Clinical Toxicology
18(8):911-914
U sat eg ui- Gomez, M.
Heveran, J.E.
C lee land, R.
McGhee, B.
TelischaX, z.
Andziej, T.
Grunberg, E.
1975
Clinical Chemistry
21 (10) : 1378-1382
Takahashi, M.
Koida, H.
Koneto, H.
Goto, Y,
Haseba , S.
1975
Pharmacology 25:348-349
Yeh, S.Y.
1975
Journal of Pharmacology
and Experimental
Therapeutics
192(1) :20 1-210
Brunk, S.F.
Delle, H.
Wilson, H.B.
1974c
Journal of Clinical
Pharmacology
14(1 1/12):581-587
(NEXT PAGP)
OJ
VO
-------
Norphinan-3,6alpha-diol, 7, 8-didehydro-4, Salpha-epoxy- 17-Bethyl- (8 CI|
Sorphinan-3,6-diol. 7, 8-didehydro-4,5-epoxy- 17-»ethyl- (5alpha,6alpha) - (9 CI)
51-27-2
51-27-2
C17-H19-N-03
MB 285.33, HP 197 C (metastable phase)
251 C (decoap)
(CONTINUED)
tlSSOE
7280
Drine
-7281
Urine
7282
Urine
EXPOSUBE SOfl IE
Infection
_.
Injection
Injection
kBALTTICAt,
METHOD
Saaiometry
Radioaetry
8
-------
Borphinan-3,6alpha-diol, 7,8-ydro-'l, 5alpha-epojy- 17-methyl- (8 CI)
Bcrphinan-3,6-diol, 7, 8-didehydro-H,5-epoxy-17-methyl- (5alpha,6alpaa) - (9 CI)
57-27-2
C17-H19-H-03
B« 285.33, SP 197 C (metastable phase), 25U C (decomp)
(CONTINUED)
TISSUE
J2&3
irine
28U
rine
285
rine
EXPOSOBE KODTE
Injection
ANALYTICAL
BETHOD
81 A
OC/BS
GC
Pluorometry
0V
Spin immunoassay
NOB BEE
OF CASES
1
a) 32
b| 2
c) «
10
RANGE
Not applicable
a) 0. 1-4.0 mg/100 ml
b) 0.1-0.2 «g/100 ml
c) 0.5-K.O mg/100 ml
..
a) 20000-2 ng Eg/ml
b) 15.2-136.1 ng Eg
BEAN
5.00 mg/dl
a) Not given
b) Not given
c) Not given
a) Not given
b) 50 ng Eg
GEBEEAL INFOR9STION
Suspected cocaine overdose fatality.
autopsy data
37 yr old, Los Angeles County, CA
CALIFOBHIA; 40TOPSIF.S: BILE; B100D;
OPISE; DRUG ABDSE; DRUGS; NARCOTICS;
FORENSIC BEDICINE; INHALATION
a) 0. S. Army separation center A, 890
tests, 1971
b) U.S. Army separation center B, 393
tests, 1971
tests, 1971
BRINE; DUOS ABUSE; DRUGS; KABCOTICS
a) Day 0 and 13 after start of heroin
withdrawal
b) Total output for first 72 hr
following withdrawal
Last dose 100-750 Bg. lean daily
intake exceeded 1000 pg
Pange of medians estimated from graph
Bilitary personnel, mean age 20.3 yr.
leading Viet Nam
TIETNAB; ADULTS; UBIHE: ANALGESICS;
CPOG ABUSE; DRUGS; SEDATIVES
REFERENCE
Nakaaura, 3.R.
Noguchi, I.T.
1981
Clinical Toxicology
18(8):895-905
Sinter, P.B.
Stahl, C. J.
Goldbaum, L.R.
Dominguez, A. H.
1971
Sciences 19 (2) :3 17-321
Robinson, B.G.
Howe, B.C.
Ream, N.W.
Siegel, H.w.
Hegge, ?. H.
1970
Clinical Pharmacology
and Therapeutics
16(2) :303-309
VO
OJ
Horphinan-3,6alpha-diol, 7,8-didehydro-H,5alpha-epoiy- 17-methyl-, diacetate (ester) (8 CI)
Hcrphinan-3,6-diol, 7, 8-di3ehydro-U,5-epoxy-17-methyl-(5alpha,6alpha)-, diacetate (ester) (9 CI)
561-27-3
C2I-H23-S-05
fl» 369.40. BP 173 C, BP 273 c at 12 mm Hg
TISSDE
7286
Elood,
plasma
EIPOSURE HOOTE
Injection
ANALYTICAL
HETHOD
BIA
NOBBER
OF CASES
a) 16
b) 3
RANGE
a) 0-160 ng/ml
b| 0.5-15 ug/ml
BEAN
a) Not given
b) Not given
GENERAL INFORMATICX
a) nen
b ) V o Be n
Dose >150 ng/day
Heroin addicts, 1 9-25 yr old
Significant reduction of testosterone
changes in those of androstenedione.
luteinizing horn one, and follicle
stinu la ting hormone
BLOOD PLASN»; DBDG ABOSE; DFDGS;
NAFCOTICS
REFERENCE
Bolelli, G.
Lafisca, S.
Flaaigni, c .
Lodi, S,
F r an cesc het t i , F .
Filicoci, H.
Hosca, B.
Toxicology 15: 19-29
-------
Borphinan-f-one, 17- (cyclopropylnethyl) -4,5alpha-epoxy-3 ,14-dihydroxy- (8 CI)
Borphinan-6-one, 17-, 24
+or- 11 ng Eq/ml at 150 «in
e) Sane as a), 3 nin. Conjugated
fern, 0.9 ng Eg/nl at 30-90 «in
f) Saie as b), 10-180 nin.
Conjugated forn, 0.8 ng Eq/Bl at 300
nin
q) Sane as c) , 3 nin. Conjugated
forn, 0.2 ng Eq/«l at 30-180 nin
h) 5a«e as d) , 3 nin. Conjugated
forn 0.2 ng Eq/nl at 15-60 nin
Mean peaks after 50 nq oral (a)-d) )
and 1 ng IV (e)-h|)
Healthy 18-30 yr olds
BLOOD PLASHJ; OBIHE; D8UGS;
HETAB01ITES
a) 48 hr cunulative excretion after
50 nq oral, as hydrochloride
b) 72 hr cunulative excretion after 1
ng I1)
Healthy 18-30 yr olds
BICOD PLASBJ: OBINE: DRUGS;
BET1BOLITES
Wall, (I.E.
Brine, D.B.
Perez-Reyes, fl.
1981
Dcuq Hetabolisn
Disposition
9 (4) :369-375
Hall. H.E.
Brine. D.B.
Perez-Reyes
1961
Druq Hetabolis
Disposition
9(4) :369-375
B.
Borphinan-6-one, 4,5alpha-€poxy-3-hydroxy-17-nethyl- (8 CI)
Borphinan-6-one, 4,5-epoxy-3-hydroxy-17-nethyl-, (Salpha)- (9 CI)
166-99-9
C17-H19-N-03
»8 285.33, BP 266-267 c (crystals fron ethanol)
TISSDE
7289
Blood,
plasna
EXPOSORE ROOTE
Injection,
Inqestion
INALTTICiL
HETHOO
BIA
NOB BEE
OF CISCS
6
BANGE
a) 1.5-0.01 nq/nl
b) 1.3-0.2 ng/nl
a) Not given
b) Hot given
GENERAL INFORMATION
a) 15 nin and 12 hr after 2 ng IV
dean AOC 83.05 ng/nl x hr)
b) "75 nin and 12 hr after 4 ng oral.
Initial neasurenent 0.6 ng/nl at 15
nin (mean AOC 87.16 nq/nl x hr)
Range of neans, estinated fron graph
25-29 yr old nonsnoXers
ACOLTS; BLOOD PLASBA; DRUGS;
NARCOTICS
Vallner, J. J.
Stewart, J.T.
F.otian, J.A.
Kirsten, E.B.
Qonigberg, I.L.
1981
Journal of Clinical
Pharmacology 21:152-156
-------
Hcrphinan-6-oner 4,5alpha-epoxy-3-iethoxy-17-aethyl- {8 CI)
Horphinan-6-one , 4,5-epoxy-3-nethoxy-17-Bethyl-, (5 alp ha) - (9 CI)
125-29-1
C18-H21-S-03
US 299.36. B
TISSUE
7290
Blood
EtPQSUSE ROOTS
Ingestioo
-01 alcohol)
ANALYTICAL
HETBOD
RIA
KUHBEK
OF CASES
a) 1
b) 1
BSNSE
a) Mot applicable
b) Hot applicable
.
flEAS
al 1.5 »g/l
b) 1.2 «g/l
GEHEEAL IMFOBflATIOH
a) Dose unknovn. 960 ig/1 ethanol
also present
b) Dose reported to be 6 oz Hycodan
(5 ag/5 al hydrocodone bitartrate) .
0.9 ug/1 diazepan and 0.6 Bg/1
nordiazepaa also present.
27 yr old drug abuser and 35 yr old
suicide victim
AUTOPSIES; SUICIDE; BIOOD; DRUG
ABUSE; DRUGS; FORESSIC HEDICIBE;
BEASUREKEBT METHODS
_
BZFEBEHCE
Cinbura, G.
Koves, E.
1981
Journal of Analytical
Toxicology 5: 296-299
Horphinan-6alpha-ol, 7,8-didehydro-4,5alpha-epoxy-3-aethoiy-17-sethyl- (8 CI)
Bcrphinan-6-ol, 7,8-diaehyaro-H,5-epoxy-3-niethoiy-17-ietbyl-. (5alpha,6alpha) - (9 CI)
76-57-3
C18-H21-H-03
nv 299.36, BP 151-156 c (after drying at 80 C)
TISSUE
7291
Bile
Elood
Blood
7294
Blood,
plasna
EXPOSURE ROUTE
Injection
Ingestion
ANALYTICAL
METHOD
RIA
GC/MS
GC/MS
Gc/ns
GC/MS
NOKBEEt
OF CASES
1
a| 1
b) 1
RANGE
..
Not applicable
app
a) 117-25 ng/»l
b) 97-15 ng/ml
MEAN
0.60 mg/dl
a) Not given
b) Not given
GENERAL INFORMATION
Suspected cocaine overdose fatality
22 yr old, Los Angeles County, .CA
CALIFOPNIA; AUTOPSIES; BILE; BLOOD;
OPINE; DRUG ABUSE; DROGS; NARCOTICS;
FORENSIC MEDICINE; INHALATION
days pre-delivecy. Morphine level
0.33 ng/*g
Stillborn infant of heroin-dependent
nother
Death froa intrauterine anoxia and
acute intoxication. Bother used
heroin and propoxyp hene during
pregnancy.
FETOS; INFANTS; BLOOD; BRAIN;
KIDNEYS; 1IVEB; LffffGS; ANALGESICS;
DRUG ABOSE; DROGS; NARCOTICS;
METABOLISM; METABOLITES
22 yr old, Los Angeles County, CA
CALIFORNIA; AffTOPSIES; BILE; BtOOD ;
OPINE; DRUG ABOSE; DRUGS; NARCOTICS;
FORENSIC MEDICINE; INHALATION
a) 1 and 8 hr after 60 ng as sulfate.
Initial measurement 110 ng/al at 0.5
hr
b) 1 and 8 hr after 60 mg as sulfate.
Initial measurement Q1 ng/ml at 0. 5
hr
Healthy subjects
ELOOD PLASMA; DROGS; NARCOTICS;
MEASUREMENT METHODS; METABOLITES
REFERENCE
Nakanura, G.R.
Noguchi, T.T.
1981
Clinical Toxicology
18(8} :895-905
Reed , D .
1981
Clinical Toxicology
18(8) :9I1-914
Hoguchi, T.T.
1981
Clinical Toxicology
18 (8): 895-905
Branson, R. K«
Nash, J.F.
1975
Clinical Chemistry
21 (13) :1956-1960
(NEXT PAGE)
OJ
*£>
Ln
-------
4orphinan-6alpha-ol, 7,8-didehydro-4, 5alFha-epoxy-3-metho:ty-17-methYl- (8 CI)
Horphinan-6-ol, 7,8-;lidehydro-4,5-epoTy-3-aethory-17-ttethYl-, (5alpha,6alpha)- (9 CI)
76-57-3
C18-B21-H-03
HW 299.36, (IP 154-156 C (after drying at 80 C)
(CONTINUED)
TISSUE
7295
Elood,
plasma
7296
Blooa,
plasma
7297
Kidney
7298
rung
EXPOSURE BOH1E
Ingestion
Injection
Ingestion
HIIALJTICAL
BETHOD
BIS
RIA
SI A
GC/BS
H08BEB
OF CASES
2
6
1
1
BAHGE
a] 200-15 ng/ml
b| 18-4 ng/nl
c) 200-4 ng/ml
d) 7-1.5 ng/Hl
a) 195-340 ng/ml
b) 102-140 ng/»l
Hot applicable
Not applicable
SEH«
a) Not applicable
b) Not applicable
c) Not applicable
d) Not applicable
a) 264 ng/ml
b) 111 ng/ml
0.02 ng/kg
0.02 mg/kg
GESERll IHFOKHHTIOH
a) 1 and 12 hr, subject 1
b) 1 and 12 hr. Betabolite
(morphine) , subject 1
c) 1 and 12 hr, subject 2
d| 1 and 12 hr. Betabolite
(morphine), subject 2
Dose 60 mg as phosphate, plus 454 mg
aspirin, 324 ng phenacetin and 64 mg
caffeine
Fstimated from graph
30 and 32 yr old nursing mothers
ArULTS; BLOOD PLASBA; SILK;
ANALGESICS: DROGS; HABCOTICS;
CAFFEINE; LACTATION
a) 65 mg, IF!, as phosphate
b) 65 mg , oral, as phosphate
Peak levels, at 0.25-1 hr (a) and
0.75-1 hr (b) .
Healthy 18-21 yr olds
B1OOO PLJSHA; DROGS; « ARCO T ICS -,
BEASOREBENT BETHODS
2100 g fetus. Bother dependent > 4
yi-
Stillborn infant of heroin-dependent
B ct he r
FF.TOS; INFAHTS; BLOOP; BR8IN;
KIDNEYS; LIVES; LUNGS; ANALGESICS;
DBUG ABUSE; DROGS; NABCOTICS;
BETABOLISB; BETABOLITES
2100 g fetus. Bother dependent > 4
yr. Borphine level 0.20 mg/kg
Stillborn infant of heroin-dependent
mother
FETDS; IHFAHTS; BLOOD; BRAIN;
KIDHE1S; LIVES; LOTSGS; 1 » A 1SE SICS ;
DROG ABUSE; DRUGS; NARCOTICS;
BZTABOLISB; BETABOLITES
REFERBSCE
Findlay, J. ». A .
DeAngelis, R.L.
Kearney, H.F.
Belch, S.B.
Findlay, J. H.
1981
Clinical Pharmacology
and Therapeutics
29(5) : 6 25-633
Findlay, J.W.A.
Butz, a.F.
Welch, R.B.
1977
Clinical Pharmacology
and Therapeutics
22(4) : 439-446
Cravey, Et.H.
Seed, D.
1981
Clinical Toxicology
18(8) :911-914
Cravey, R.H.
Reed, D.
1981
Clinical Toxicology
18(8) :911-914
(NEXT PAGE)
-------
Borphinan-6alpha-ol, 7,8-didehydro-4,5alpha-epoxy-3-methoKy-17-methyl- (8 CI)
Mcrphinan-6-ol, 7,8-didehydro-4,5-epoxy>3-methory-17-methyl-, {5alpha,6alpha)- (9
76-57-3
C18-H21-N-03
BS 299.36, BP 154-156 C (after drying at 80 C)
(CONTINUED)
TISSUE
_.
7299
Bilk
7300
Urine
EXPOSURE EOOTE
Ingestion
Injection
ANALYTICAL
HETHOD
EIA
51 A
GC/BS
NOHBEB
OF CASES
2
1
BAHGE
a) 500-20 ng/ml
t» 2-20 ng/ml
c) 500-5 ag/ml
d) 8-3 ng/«l
Hot applicable
HEAN
a) Not applicable
b) Not applicable
c) Not applicable
d| Not applicable
0. 11 mq/dl
GENEEAL INFOEBATIOH
a) 1 and 12 hr. Initial neasurenent
105 ng/»l at 0.5 hr, subject 1
b) 0.5 and 12 hr. Metabolite
(norphine), subject 1
c) 1.5 and m hr. Initial measurement
300 ng/ml at 1.0 hr, subject 2
d) 1.5 and 36 hr. Setabolite
(morphine), subject 2
Dose 60 ng as phosphate, plus 454 ng
aspirin, 3214 eg phenacetin and 64 mg
caffeine
Estimated from graph
30 and 32 yc old nursing mothers
AEULTS; BLOOD PLASBA; BILK;
ANALGESICS; DRUGS; NSECOTICS;
CAFFEINE; LACTATION
Suspected cocaine overdose fatality
37 yr old, Los Angeles county, CA
CALIFORNIA; AUTOPSIES; BILE; BLOOD;
UEISE; DUOS ABDSE; DRUGS; NARCOTICS;
FOBESSIC MEDICINE; INHALATION
FinJlay, a. B.A.
De&ngelis, R.L.
Kearney, B. F.
Welch, R.B.
Findlay, a.B.
198)
Clinical Pharmacology
and Therapeutics
29(5):625-633
Makanura, G.E.
Noguchi, T.T.
1981
Clinical Toxicology
18(8) :895-905
CO
VO
-------
Nicotine (3 CI)
Pjridine, 3- O-aethjl-2-pyri:olidin7l) -, (S)- (9 CI)
51-11-5
C10-H14-N2
B» 162.23, HP < -80 c, BP 217 C (partial decomp) at 7145 »n Hq. 123-125 c at 17 ml Hg, VP 1 mu Kg at 61.8 C
TISSUE
1
7301
Blood,
plasma
7302
Blood,
plasna
EXPOSD8E R001E
Inhalation
Oral
absorption
Injection
HILITICAL
HETHOD
GC
NDaBEB
OF CiSES
163
6
BJSGE
a) 6.2-91.2 a.ol/1
b) 4.9-165.8 n»ol/l
c) 57.3-418.8 Iinol/l
d| 78.9-797.2 mol/1
e) 37.0-K74.7 n»ol/l
f) 66.6-431.6 nial/1
g) 130-295 niol/1
h| 800-150 n«ol/l
a) 3-23 ag/ml
b) 4-27 ng/»l
37.9 nmol/1
72.8 nmol/1
222.3 naol/1
464.9 nmo1/1
226.3 naol/1
296.5 naol/1
Mot given
Not given
a) Not given
b) Not given
GENERAL INFORMATION
a) il subjects, never ased snuff,
range 3.7-102.3 nmol/1 before
snuffing. Bean decrease after
snuffing 3.1 naol/1
b) 10 occasional snuffers, range
0-180.0 naiol/1 before snuffing, mean
increase after snuffing, 12.3 *or-
20.3 nmol/1
c) 8 daily snuffers, range 22.2-238.6
nmol/l before snuffing, aean increase
after snuffing, 77.7 + or- 70.3 naol/1
d) 5 multiple dose snuffers, range
0-2*11. 7 nnol/1 before snuffing, mean
increase after snuffinq, 332.9 *or-
199.1 nmol/1
€) 136 heavy cigarette smokers 2 nin
after finishing cigarette, aean
increase after 1 cigarette 62.3
nnol/1 *or-
-------
Sitroglycerin (8 CI)
1,2,3-Propaoetriol, trinitrate (9 CI)
55-63-0
C3-B5-K3-09
BB 227.09, BP 2.8 C (labile), 13.5 C (stable)
7303
Blood
EXPOSURE ROUTE
ANALYTICAL
BETBOD
GC
NOB BEE
OF CASES
RANGE
a) 0. 15-0. 18 ng/ml
b) 0.36-0.47 ng/ml
c) 0.37-0.24 ng/al
d) 0.20-0.88 ng/ml
a) 0. 17 ng/ml
b) 0.41 ng/Bl
c) Not given
d) Hot given
GENERAL IHFORBATIOB
a) Peaks, 30 Bin after 16 ag to 25 sg
en. <0.05 ng/ml at 90 «in (3
subjects)
b) Peaks, »5 Bin after 16 ig to 100
sq cm. 0.16-0.32 (Bean 0.25) Bg/il
at 90 nin, (3 subjects)
c) 60 and 90 Bin after 16 mg to 100
sg ci. 0.31 ng/sl at 30 Bin (1
subject)
d) 30 and 60 Bin after 32 »g to 100
sg cm. 0.83 ng/Bl at 90 Bin (1
subject)
2T ointment applied to chest
Healthy adults
•CULTS; DRUGS: VASODILATORS: BLOOD
Sved, S.
McLean, H.s.
flcGilveray, I.J.
1981
Journal of
Pharmaceutical Sciences
70(12) : 1368-1369
Cialic acid (8 CI)
Ethanedioic acid (9 CI)
140-62-7
C2-B2-04
tlV 90.04, BP 101-102 C, BP 150 C (sublimes)
TISSUE
7304
Orine
EXPOSURE ROUTE
Ingestion
ABALYTICAL
I"ETHOD
Eaaioietcy
NOHBEB
OF CASES
a) 15
:) 4
d) 7
BADGE
_
a) Not given
c) Hot given
d) Mot given
HE IN
) 0.49 *or- 0.07
) 0.64 +OC- 0.14
mol
) 0.70 *or- 0.39
mol
d) 1.20 tor- 0.75
mmol
GENERAL INFORBJTICN
a) Controls
c) Ileocecal resection patients
A) End to side jejunoileal bypass
patients
36 hr excretion after 8 ng (60 umol) .
Ka oialate and 2.5 uCi of [C-1H ]
oxalate after overniqht fast
d) significantly different from a)
and b) .
Patients and noraal controls on no
other drugs before or during study.
UEI8E; HINEHAI. DEPOSITS; SIHERflL
METABOLISM; SSPDEN
REPEEEHCE
Tiselius, H.-G.
Luadstcoa, B.
Hilsson, H.-i.
1981
Clinical Chemistry
27(10) : 1682-1685
-------
p-Acetophenetidide (8 CI)
Acetamide, H-(4-ethoxyphenyl) - (9 CI)
62-10-2
C10-B13-N-02
HB 179.21, HP 130-135 C
TISSUE
7305
Blood,
plasma
7306
Bilk
EXPOSURE KOUTE
Ingestion
Ingestion
ANALYTICAL
HETHOD
BI»
an
B08BEB
OF CASES
2
2
BANGE
a) 900-3 ug/ml
b) 2000-300 ng/ml
c) 3000-2 ng/ml
d) 1500-150 ng/ml
a) 500-3 ng/ml
b) 1500-500 ng/ml
c) 2000-15 ng/ml
d) 1500-50 ng/ml
._
a) Sot applicable
b) Not applicable
c) Hot applicable
d) Not applicable
a) Mot applicable
b) Hot applicable
c) Hot applicable
d) Hot applicable
GENERAL INFOBSATION
a) 0.5 and 12 he, subject 1
b) 1.5 and 12 hr. Initial
measurement 1500 ng/ml at 0,5 hr.
Phenacetin netabolite
(acetaminophen), subject 1
c) 1 and 12 hr, subject 2
d) 1 and 12 hr. Phenacetin metabolite
(acetaminophen), subject 2
Dose 324 ng plus 454 no. aspirin, 64
ng caffeine and 60 mg codeine
phosphate
Estimated from graph
30 and 32 yr old nursing mothers
ADULTS; BLOOD PLJSBA; BILKJ
ANALGESICS; DROSS; NARCOTICS;
CAFFEINE; LACTATION
a) 0.5 and 12 hr, subject 1
t) 3 and 12 hr. Initial measurement
700 ng/ml at 0.5 hr. Phenacetin
metabolite (acetaminophen, subject 1)
c) 1 and 7 hr, subject 2
d) 2 and 20 hr. Initial measurement
800 ng/ml at 0.5 hr. Phenacetin
metabolite (acetaminophen, subject 2)
Dose 321 mg plus »50 mg aspirin, 60
ng caffeine and 60 mg codeine
phosphate
Estimated from graph
30 and 32 yr old nursing mothers
ADULTS; BLOOD Pt,»StU; RILK;
AHALGESICS; DBOSSi NARCOTICS:
CAFFEINE; LACTATION
EEFEREHCE
Findlay, J.B.H.
DeAngelis, R.L.
Kearney, fl.F.
Belch, E.n.
Findlay, J.B.
1981
Clinical Pharmacology
and Therapeutics
29(5):625-633
Tindlay, a.fl.H.
DeAngelis, R.L.
Kearney, H. p.
Belch. P.fl.
Findlay, J.B.
1981
Clinical Pharmacology
and Therapeutics
29(5):625-633
O
O
Phenethylamine, alpha-methyl-, (*) - (8 CI)
Eenzeneethanamine, alpha-methyl-, (S)- (9 CI)
E1-60-9
C9-H13-H
BS 135.20, BP 200-203 C
7307
SSDE
7
ne
EXPOSURE R00TE
Ingestion
__ _
»N»LITICAI
BETHOD
GC
NUMBER
OF CASES
12
RANGE
a) Not given
b] Hot given
c) Hot given
BEAN
a) 28 * of dose
b) 29% of dose
c) 28% of dose
-. . . —
GENERAL IN FOR BAT! OH
a) After 5 mg/70 kg
b| After 10 mg/70 kg
c) After 15 mg/70 kg
12 hr cumulative excretion
Healthy 21-30 yr olds
dose (evaluated by modified Cornel
neoical Index)
ORIN5; AOTONOHIC DBDGS; DRUGS;
PSTCHOTROPIC DRDGS
REFERENCE
Evans, U.S.
Sinbish. S.
Griffis, L.
Bartz, R.
Brown, D.J.
Rodda, B.E.
Lomberger, L.
Forney, R.B.
1977
Sciences 22(11:197-201
—
-------
Phenethylamine, alpha-methyl-, (»-) - (8 CI)
Benzeneethananine, alpha-methyl-, (*-}- (9 CI)
300-62-9
C9-H13-N
BW 135.20, BP 200-203 C at 760 iti Hg, 82-85 C at 13 mm Hg
TISSOE
7308
Blood
7309
Elood,
plasma
7310
Brain
7311
Kidney
7312
Liver
7313
Lung
73 1«
(•uscle
EXPOSURE ROUTE
In-tection
Ingestion
Injection
Injection
Injection
Injection
Injection
ANALYTICAL
HBTHOD
TIC
Fluoroaetry
Enzymatic
TLC
Fluorometry
TLC
Fluorometry
TLC
Fluorometry
TLC
Fluorometry
TLC
Fluorometry
SUflBEB
OF CASES
1
2
1
1
1
1
1
B1BSE
Not applicable
a) 81-15 ng/ml
b) 10-71 ng/ml
c) 124-20 ng/ml
d) 96-10 ng/ml
Not applicable
Not applicable
Hot applicable
Not applicable
Not applicable
__
SEAS
0.7 mg/100 mg
a) Not given
b) Not given
c) Not given
d) Not given
0.3 mg/100 mg
1.9 mg/100 mg
1.2 ng/100 mg
1.7 mg/100 mg
0.4 ng/100 mg
GEHESAL INFOS HATIC»
Lethal overdose
22 yr old, Netherlands
AUTOPSIES; BLOOD; BBAIN; KIDHEYS;
LIVER; LONSS; BUSCLES; UBINE; DBUG
AF.OSE; DRUGS; PSYCHOTB OPIC DRUGS;
FORENSIC BEDICINE; NETHERLANDS
._
a) 5 and 27 hr after 0.23 mg/kg (free
base), as d-amphetamine sulfate.
Initial measurement 51 ng/ml at 2 hr
b) 1 and 3 hr after 0.23 mg/kg (free
base), as 1-amphetamine sulfate.
Final measurement 13 ng/ml at 2<* hr
c) 3 and 25 hr after 0.5 mg/kg (free
tase) , d-ampheta mine sulfate.
d) 1 and 30 hr after 0.5 mg/kg (free
base), as 1-amphetamine salfate
Estimated fcom graph
BLOOD PLAS1J; DBUGS; PSYCHOTBOPIC
DRUGS; MEASUREMENT WBTHODS
lethal overdose
22 yr old, Netherlands
AUTOPSIES; BLOOD; 3SAIM; KIDNETS;
LIVES; LONGS; 10SCLES; UBISE; DBtIG
ABDSS; OBOGS; PSICHOTBOPIC DRUGS;
FOBFNSIC HEDICIBE; NETHERLANDS
22 yr old, Netherlands
AUTOPSIES; BLOOD; BBAIN; KIDNEIS;
IIVZR; LONGS; KUSCLES; UBINE; CBUG
ABUSE; DBUGS; PSYCHOTBOPIC DEUGS;
FOPENSIC BEDICISE; NETHPBLSNDS
Lethal overdose
22 yc old, Netherlands
AUTOPSIES; BLOOD; BBAIN; KIDNETS;
LIVEB; LUNGS; 1USCLES; UBINE; DBUG
ABUSE; DBUGS; PSTCHOTBOPIC DBUGS;
FOBENSIC flEDICIHE; NETHERLANDS
lethal overdose
22 yr old, Netherlands
AOTOPSIFS; BLOOD; BRAIN; KIDNETS;
LITER; LUNGS; HDSCLES; OPIHE; DRUG
ABUSE; DRUGS; PSTCHOTEOPIC DRUGS;
FOBENSIC BEDICINE; NETHERLANDS
Lethal overdose
22 yr old, Netherlands
AOTOPSIES; BLOOD: BRAIN; KIDNETS;
LIVEB; LUNGS; BOSCLES; URINE; DBUS
ABUSE; DPUGS; PSYCHOTBOPIC DRUGS;
FOEEHSTC MEDICINE; NETHERLANDS
REFERENCE
van Hoof, p.
Heyndrickx, A.
Timperman, J.
197H
Archives of Toxicology
32:307-312
Kreuz, D.S.
Axelrod, J.
197
-------
Phenethylamine, alpha-net hyl-, (»-)- (SCI)
Benzeneethanamint, alpha-methyl-, (*-)- {9 CI)
300-62-9
C9-H13-N
MH 135.20, BP 200-203 C at 760 IB Hg, 82-85 C at 13
H<3
(COSTIKOED)
TISSUV
7315
Urine
EXPOSURE ROUTE
Injection
ANALYTICAL
SETHOD
TLC
Fluoroaetry
NUMEEE
OF CASES
1
RANGE
Hot applicable
MEAN
24.2 ag/100 ng
GENERAL INFORBATION
Lethal overdose
22 yr old, Netherlands
LIVEF; LUNGS; BOSCLES; URINE; DRUG
ABOSE; DRUGS; PSYCHOTROPIC DRUGS;
FORENSIC HEDICISE; HETHF.SL ANDS
REFSREHCE
van Hoof, F.
Heyndrickx, \.
Timpcraan, J.
1971
32:307-312
Phenol, p- (dipethylanino) -, hydrochloride (8 CI)
Phenol, »- (dinethylani.no)-, hydrochloride (9 CI)
5862-48-4
C8-H11-N-O.C1-H
H8 173.66
TISSUE
7316
Urine
EXPOSOBE ROUTE
Injection
IHIITTICIL
BETHOD
TLC
Colorinetry
NOBBEB
OF CASES
6
BASSE
a) 33.2-50. 7X
t) 3.7-14.9*
c) 12.1-17.5%
d) 59. 9-74. 4*
e| 6.9-15.4X
f) 0.3-0.7J
40.7 »or- 4.3*
11.6 *or- 1.6J
15.3 *or- 1.8X
67.6 »or- 4.2J
9.4 +or- 2.3*
0.5 tor- 0.1*
GENERAL IHFOBBATIOS
a) 4-dinethylaninophenol
(DnAP)-glucuronide
t) D1AP-S04
c) DHAP-thioethers
d) a) *b)»c)
e) Tris-(cys)-DHAP
f) Tcis-(B-acys)-D8AP
Hetabolites in 2» hr urine after 3.2
ig D»AP-HCL/kg IT
K of dose
Healthy volunteers, wt 70-90 kg
ADULTS; URINE; DRBSS; BETiBOLISB;
BETABOLITES
Jancso, p,
Szinicz, L.
Eyer, P.
1981
Archives of Toxicology
47:39-45
Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl-
54340-58-8
C15-H23-K-0
B« 233.39
TISSUE
7317
Blood,
plasna
EIPOSnBE HOUTE
Injection
HALTTICM.
HETBOD
.
HPLC
80HEEE
OF CASES
26
BINGE
a) 22-343 ng/al
b) 16-124 ug/al
c) U-»7 ag/«l
e) <3-4 ng/«l
i) <3-3 ng/»l
g) <3 ng/.l
HEAD
a) Not given
b) Not given
c) Not given
e) Not given
f| Not given
g) Hot given
GE8ERAL INFORBATION
a) Baternal levels (12 subjects)
b) Initial neonatal levels (13
subjects)
birth (7 subjects)
d) Neonatal levels 8 hr after birth
(2 subjects)
(6 subjects)
t) Neonatal levels 18 hr after birth
(5 subjects)
g) neonatal levels 24 hr after birth
(6 subjects)
Baternal dose 100-150 »g IB about 3
hr before delivery, proceeded in 3
cases by 1 or 2 doses at 3 hr
intervals.
Pregnant uoaen 55-91 kg (aean 72 kg)
AUDITS; NEBBORN; BLOOD; ANALGESICS;
DRUGS; PREGNANCY
Fr
Fr
Ro
19
Br
cl
Franklin, E.A,
Frost, T.
Bobson, p.J.
Jackson, H.B.A.
1981
British Journal of
Clinical Phacnacology
12:88-90
-------
Phenol, g oral.
Initial measurement 16 nnol/1 at 15
•in
d) 0.5 and 8 hr after 10 mg , oral.
Initial measurement 58 nnol/1 at 15
Bin
273 nnol/1 at 1-1.5 hr for 2.5 nig
oral dose and 58 nnol/1 at 3 hr f or a
2.5 ug IV dose
Pange of means
Healthy 22-25 yc olds
(federate increase in heart rate and
systolic pressure. HO effect on
diastolic pressure. IV and maximum
oral dose resulted in a feeling of
te nsi on an 3 pal p ita t ions
BLOOD PLASMA; AtJTONOMIC DRUGS; DRUGS
REFERENCE
Graffner, c.
Hoffmann, K.-J.
Jotmsson, G,
Lundborq, P.
Ronn, 0.
1981
European Journal of
Clinical Pharmacology
20:91-97
Phenothiazine, 10-(2-(dimethylaiino) pcopyl) - (8 CI)
IOH-Phenothiazlne-10-ethanaaine, »,H.alpha-trimethyl- (9 CI)
60-87-7
C17-B20-'' -S
f« 284.it, HP 60 C, BP 190-192 C at 3 » Bg
O
U)
TISSUE
T319
Blood,
plasna
EXPOSURE BOOTE
Ingestion
Recta 1
ASALtTICiL
METHOD
HPLC
NUHBEE
OF CASES
6
BADGE
a) Hot given
b) Hot given
c) Not given
d) Hot given
MEAN
a) 39.2 +or- 8.2
ng/ffll
b) 11.2 +or- 2.6
ng/al
c) 10.2 tor- 2.1*
ng/nl
d) 7.5 +or- 2.7 ng/ml
GEHEBAL INFORflATION
a) 2.5 *or- 0.6 hr after 50 »g in
solution, oral
b) 2.7 +o - 0.6 hr after 25 sg in
solution ral
c) 3.1 +o - 0.7 hr after 25 ing in
solution, rectal
d) 5.2 +o - 0.9 hr after 25 »g in
supposito y, rectal
Peak levels
As hydrochloride
Health volunteers, 21-27 yr old.
=8-84 Xg
dose of 50 ig
RDOLTS; BLOOD SERUM; ANESTHETICS;
DROGS; SEDATIVES; ANTIHISTAMIHE ;
COMPARATIVE EVALUATION
REPERESCE
Moolenaar, p.
Ensing, J.G.
Bolhuis, Q.G.
visser, J.
1981
International Journal
of Pharmaceutics
9:353-357
-------
Phenothiazine, 10-(3-(4-nethyl-1-piperazinyl)propyl)-2-(trifluoronethyl) - (8 CI)
10H-Phenothiazine. 10- (3- (it-methyl- 1-piperaziny 1) propyl) -2- (trirluoronethy 1) - (9 CI)
1 17-89-5
C21-H2H-F3-S3-S
an HQ7.09, BP 202-210 c at 0.6 me Hq
TISSUE
7320
Bloofl,
plasma
Eloa<3,
plasma
1322
Blood,
plasma
EXPOSURE ROUTE
ABALYTICAl
METHOD
Radioreceptor
assay
GC
NUMBER
OF CASES
a) 1
b| 1
c) 1
d) 1
ai 2
b) 7
0) 3
f) 2
RANGE
a) < 1.0 ng/Il
b| 2.0-6.5 ng/Bl
c) 2. 6- 1H. 6 ng/nl
d) 9.3-12.5 ng/»l
a) 0.3-0.5 ng/ml
b) 0.5-2.0 ng/«l
o) 0.5-1.5 ng/al
d) 2.0-3.0 ng/ul
f| 9.9-10 ng/al
. ._ . .
HEAS
a) Sot given
D| Mot given
c) Not given
d) Not given
at Not give
b) Hot give
c) Not give
d) Sot give
f) Sot give
GENERAL INFORMATION
a) it mg/day
b) 15 »g/day
c) 15 ng/aay
d) 30 ig/day
Range of weekly Beans. Treated 3 wk.
Absence of coffee and tea during wk 2
did not increase bioavailafcility.
Mentally retarded patients with
psychotic disturbances.
BE" ZEALAND; ADULTS; BEHAVIOR
DISORDEFS; flENTlL RETARDATION; BLOOD
PLRSRA; PSICBOTKOPIC DSUSS ;
CCHPARATIVE EVALUATIONS; DIETS;
CSOSS; CAFFEINE
ng as hydrochloride
Psychiatric patients
CENTRAL NERV00S SYSTEM DISEASES;
BLOOD PLASMA; DBOG THEESPY; DEOOS;
PSYCHOTPOPIC DRUGS; MEASUREMENT
METHODS
a) 7 mg/day
b) 10 ng/day
c) 20 ng/day
d) 25 «g/day
f) 60 »g/day
graph
Schizophrenic patients undergoing
therapy
BLOOD PLASMA; DRUS THERAPY; DROSS;
TRANQUILIZERS; MEASOBEBENT METHODS
REFERENCE
Bowen, S.
Taylor, K.H.
sibb, I. A. Mel.
1981
Lancet
1 (8231) : 1217-1218
Sipes, I.S.
1981
Journal of
Ch rona t ogra ph y
223:95-102
Javaid, J.I.
Dekirvenjian, H.
Davis, J.H.
1982
Pharmaceutical Sciences
-p-
o
Phenothiazine, 2-chloro- 10- (3- (diðylanino) propyl) - (8 CIJ
IOH-Phenothiazine-10-propanaiine, 2-cbloro-N,N-diB€thyl- {9 CI)
50-53-3
C17-B19-C1-N2-S
B« 318.89
TISSUE
7323
Blood
732H
Blood
EXPOSURE ROUTE
ANALYTICAL
METHOD
GC
DV
NUMBER
OF CASES
1
1
RANGE
a) Hot applicable
b) 0.0-0.1 »(]*
a) Mot applicable
b) Hot applicable
(KBIT
HEAN
a) 0.5 agX
b) Hot given
a) 0.6 ag/lOOg
b) 1.9 ig/IOOg
PAGE)
GENERAL IKFORHATIOH
a) XAD-2 resin extraction
b) Solvent extraction, 2 nethods
Fatal poisoning
AUTOPSIES; BLOOD: BRAIfc; KIDNEYS;
LI7EE; DBTC ABUSE; DB3GS; FORESSIC
MIDICIKE; MEASDREBENT METHODS
a) Solvent extraction lethod
b) XAD-2 resin bag extraction lethod
Poland
POLAND; BLOOD; BRAIB; LIVES; DKDG
ABUSE; DRUGS; MEASOEEMENT METHODS
REFERENCE
Bogusz, H.
Gierz, J.
Bialka, J.
1978 a
Archives of Toxicology
HI: 153-162
Bogusz, H.
Gierz, J.
1978b
Forensic Science
International 12:73-82
-------
Phenothiazine, 2-cKloro-IO-(3-(ailethylailino) propyl)- (8 CD
IOR-Phenothiazine-10-propananine, 2-chloro-H,H-di»ethyl- <9 CI)
50-53-3
C17-H19-C1-N2-S
B« 318.89
(CONTINUED)
TISSUE
7325
Blood,
plasaa
7326
Blood,
plassa
7327
Blood,
7328
?rain
EXPOSURE ROUTE
ANALYTICAL
METHOD
Badioreceptor
assay
HPLC
RIA
N DPI BEE
OF CASES
a) 1
b) 1
c) 1
d) 1
BINGE
a) 5.8-29.3 ag/il
b) H9.5-67.S ng/«l
c) 26.5-81.8 ng/il
d) 90.3-141.9 ng/al
a) Not given
b) Nat give
d) Hot give
e) Not give
f) Not give
_.
a) ot give
!i| ot give
c) ot give
d) ot give
e) ot give
f) Hot give
b) 0.1-1.9 igX
(NEXT
BEAN
a) Not given
b) Not given
c) Not given
d) Bat given
a) 27.6 *or- 6.1
ng/nl
ng/»l
c) 19.0 »or- 4.1
ng/nl
d) 64.7 »or- 19.9
ng/Bl
e) 15.3 »or- 4.9
ng/ml
f) 85.2 »or- 18.0
ug/il
a) 87.9 +or- 26.8 ng
Eg/ml
b) 119.9 »or- 13.6 ug
BS/UI
c) 91.0 »or- 15.5 ng
Eg/ Hi
3) 126.5 »or- 24.1 ng
Eg/nl
e) 77.0 »or- 18.0 ng
Eg/ml
f) 147.5 *oc- 11.3 ng
Eg/il
b) Not given
PAGE)
GENERAL INFORMATION
a) 100 ag/day
b) 200 ag/day
c) 300 ag/day
d) 600 eg/day
Range of weekly Beans. Treated 3 wk.
Absence of coffee and tea during wk 2
did not increase bioa^ailatality.
Mentally retarded patients with
psychotic disturbances.
NEW ZEALAND; ADO ITS ; BEHAVIOR
DISORDERS; MENTAL BETARDATION; BLOOD
PLASMA; PSYCHOTROPIC DRUGS;
COMPARATIVE EVALUATIONS; DIETS;
C80G5; CAFFEINE
a) Week 5, without propranolol, 7
cases
c) Week 6, without propranolol, 6
cases
d) week 6, with propranolol, 6 cases
e) week 7, without propranolol, 6
cases
f) week 7, with propranolol, 6 cases
Dose 2.5-13.8 >g/kg (aean 6.7
•g/k#)/day for 7 vk with or without
"4.6-10.0 ag/kg/day propranolol.-
31-56 yr old schizophrenics
BIOOD PLiSHA; BLOOD SEtmn;
AHTIAEEHYTHMIC AGENTS; DROG
INTER ACTION; DRUGS; TEANQUILIZEES;
METABOLITES: BEHAVIOR DISORDERS
a) Week 5, without propranolol, 7
cases
b) Keek 5, with propranolol, 7 cases
c) Meek 6, without propranolol, 6
cases
d) Week 6, with propranolol, 6 cases
e) Week 7, without propranolol, 6
cases
f) week 7, with propranolol, 6 cases
Dose 2.5-13.8 ng/kg {aean 6.7
•gAq)/^ay for 7 wk with or without
1.6-10.0 ag/kg/day propranolol.
31-*>6 yr old schizophrenics
BLOOD PIASMA; BLOOD SEBOH;
ANTIABRHYTHflIC AGEHTS; DROG
INTERACTION; DRUGS; TP ANQUILIZERS ;
METABOLITES; BEHAVIOR DISORDERS
.
b) solvent extraction, 2 nethods
AUTOPSIES; BLOOD; BRAID; KIDNEYS:
LIVER; DRUG ABOSE; DROSS; FOMHSIC
BEDICINE; BEJS08EHENT METHODS
REFERENCE
Bowen, S.
Taylor, K.S.
sibb, I. A. BcL.
1981
Lancet
1(8231) :1217-1218
Peet, H.
fliddleiiss, D.N.
1980
lancet 2(8201) :978
Peet, B.
Oiddleiiss, D.N.
rates, 8. A.
1980
lancet 2(8201) :978
Gierz, J.
1978a
Archives of Toxicology
41:153-162
o
01
-------
Pbenothiazine, 2-chloro-10-(3-(diiethylaiino)propyll- (8 CI(
10H-Phenothiazine-10-propana«ine, 2-chloro-N,N-di«ethyl- (9 CI)
50-53-3
CV7-H19-C1-S2-S
BS 318.81!
(CONTINUED)
TISSUE
7329
Brain
7330
Kidney
7331
Liver
7332
liver
EXPOSURE ROUTE
ANALYTICAL
BETHOD
GC
UV
GC
0»
NUBBER
OP CASES
1
2
2
1
BADGE
a) Hot applicable
c) Hot applicable
a) 0.5-5.3 »g*
o| 0.2-3.7 «gt
a) 1. 1-11.8 »g%
b) 0.8-11.3 »g*
a) Hot applicable
b) Not applicable
HEAN
a) 2.3 Ag/100g
b) 5.7 «g/IOOg
a) Not given
b) Hot given
a) Not given
b) not given
a) 11.6 ag/IOOg
b) 23.1 »g/100q
GENERAL IBF08HATIOK
a) Solvent extraction Bethod
b) TAD- 2 resin bag extraction lethod
Fatal overdose case
POLAND; BLOOD: BRAIN; LIVER; DPUG
ABUSE; DEUGS; HEASDRF.BEHT BETHODS
a) 3CAD-2 resin extraction
b) Solvent extraction, 2 methods
AUTOPSIES; BLOOD: BRAIN; KIDHEYS;
LIVER: DRUG ABUSE; BROGS ; FOIBNSIC
HEDICIHE; HEASOEEBB9T BETHODS
a) JAD-2 resin extraction
AUTOPSIES; BLOOD; BRAIS; KIDNEYS;
LIVER; DRUG ABUSE; DRUGS; TORBNSIC
BEDICI»E; BEJSOB2HEHT HETHODS
a) Solvent extraction nethod
b) XAD-2 resin bag extraction lethod
Fatal overdose case
Poland
POLUHD; BLOOD; BRMN; LIV8R; DSUS
AEOSE; DRUGS; BEASOREBENT BBTBODS
SJFBRESCE |
1
Boqusz, n.
Gierz, J.
Blalka, J.
1978b
International 12:73-82
Bogusz, M.
Giecz, J.
1978a
Archives of Toxicology
11:153-162
Bogusz, tf.
G ier z, J .
Bialka, J.
1978a
Archives o£ Toxicology
m: 153-162
Bogusz, B.
Gierz, J.
Bialka, J.
1978b
Forensic Science
International 12:73-82
o
ON
Phcsphonic acid, (1, 2-epoxypropyl) - , (1B,2S)-(-)- (8 CI)
Phcsphonic acid, (3-«ethyloxiranyl)-, (25-cis)- (9 CI|
:3155-02-»
CJ-HT-O^-P
BS 138.1, BP approx 9H c
7333
Blood,
serun
EXPOSURE ROUTE
Injection
Inqestioa
ANALYTICAL
BETHOD
Bicrobio logical
NUSBER
OF CASES
7
RADGE
a) 132-4.5 ug/al
b) 259-6.8 ug/>l
c) 0.2-7. 1 ag/ml
d) 0.3-9.4 ug/nl
HG&N
a) Not given
b) Not given
c) Not given
d) Not given
| GEBESAL IHFOBBSTION
1
a) Initial level and 8 hr after 20
ngAg IV
b) Initial level and 8 hr after 10
»g/kg IV
c) 0.25 and 2 hr after 20 ig/kg oral.
Final leasurenent 0.7 ug/»l at 2* hr
d) 0.25 and 1 hr after 40 »gAg oral.
Final Measurement 1.3 ug/al at 24 hr
Range of Means, esti«ated froi graph
Healthy 25-56 yr olds
BLOOD SERUB: URINE; AHTIBIOTICS;
DRUGS
1
Goto, B
Sagiyan
Dakajii
Taaashi
1981
Antiiic
and Che
20 (3): 3
iEFERENCE
. »•
, S.
a, H.
obial Agents
otherapy
13-397
(SEXT PAGE)
-------
Phcsphonic acid
Phcsphonic acid
23155-02-1
C3-H7-01-P
»« 138.1. HP approx
(1,2-epozypropyl)-, (1S,2S)-{-)- (8 CI)
<3-aethyloiiranyl)-, (2E-cis) - (9 CI)
(CONTINUED)
TISSOE
7331
Ocine
EXPOSURE POUTS
In-fection
Ingestion
ANALYTICAL
BETHOD
Microbiological
Klin BEE
OF CASES
7
BINGE
a) 78-83* of dose
b) 18-21% of dose
BEAN
a) Not given
b) Hot given
GENERAL INFORBATION
a) 21 hr output after 20 or 10 ag/kg
IV dose
b) 21 hr output after 20 or 10 ag/kg
oral close
Range of leans, estimated from graph
Healthy 25-56 yr olds
BLOOD SERUB; OBINE; ANTIBIOTICS;
DP.OGS
REFERENCE
Goto, w.
Sugiyama, n.
Nakaliaa, s.
Yaaashioa, H.
1981
Antiaicrobial Agents
and cheaothera py
20(3):393-397
Pbcsphorus
7723-11-0
P
AtW 30.97376, HP "W.I C, BP 280 C, ?P 10 am Hg at 127 C
TISSOE
7335
Biooa,
secun
7336
Blood,
serum
EXPOSURE POOTE
In-jection
ANALYTICAL
BETHOD
Chen
NUHBEB
OF CASES
100
1
BANGE
a) Hot given
b) Sot given
c) Hot given
d) Hot given
a) Hot applicable
b) Hot applicable
c) Hot applicable
d) Hot applicable
e) Not applicable
f) Hot applicable
a) 3. 76 +or- 0.65
mg/100 «1
b) 3.73 »or- 0.80
Big/100 •!
c) 3.85 +or- 0.72
>g/100 «1
d) 3.59 »or- 0.85
Bg/100 al
a) 6.2 »q/100 il
b) 21.« ng/100 ui
c) 8.1 ag/100 il
d) 5.6 iig/100 .1
e) 3.9 ig/100 al
f) 4.5 »g/100 •!
(NEXT PAGE)
SENEP.AL INFORHATIUM
a) 75 women lactating 2 no or aore
b) 25 women froa a)
c) Women in b) , 1 mo. after
supplementation with 500 mg Ca and
1,fOO 10 (KO ug) vitaain D daily
d) "25 nonlactating controls, no
supplement
22-31 yr olds. North India
Serun chemistry suggested
osteomalacia, but radiographs of
pelvis and dorsolumbar spine shoved
no abnormalities.
OSTE09ALACIA; DIETS: LACTATION;
PREGNANCY; CALCIOH; PHOSPHORUS;
INDIA; BONE DISEASES; NUTRITIONAL
DEFICIENCIES; NUTRITIONAL DISORDERS;
BLOOD SER01
a) 13 mo before adaission
b) At admission, 12 hr after Fleet
enema (238 mEg phosphate)
c) Day 2, after 180 ag Ca gluconate,
81 mg ca chloride, 10 mEq NaHC03, all
IV
d) Day 3, additional 90 mg Ca and 10
mEg HaHC03
e) Day 1
f) Day 7
1.5 yr old with chronic renal failure
carpopedal spasm, hyperventilation,
diarrhea, tachycardia
CHILDREN; KIDNEY DISEASES; BLOOD
SE'Ud; CALCIUH; PHOSPHORUS
«arya, R.K.
Rathee, s.
Acora, S.R.
1981
Annals of Nutritional
fletabolisa 25:56-61
Oxnard, S.c.
O'Bell, J.
Grupe, H.E.
1971
Pediatrics
53(1) : 105-1 06
-------
Phcsphorus
7723-11-0
f
At« 30.97376, HP «1.1 C, BP 280 C, VP 10 mm Hg at 127 C
(CONTINUED)
7337
Blood,
serus
7338
Or ine
EXPOSURE FOOTS
Ittgest'ion
ANALYTICAL
BETHOD
Colorimetry
SDH BEE | E»NGE
or OSES
a) 10
bl 20
C) 20
8
a) 4.2-5.7 »g/100 •!
b) 4.2-5.1 mg/100 »1
c) 1.3-5.0 mg/100 111
-
a) Not given
b) Hot given
c) Nat given
d) Not given
e) Not given
£) Not given
g) Not given
h) Not given
HEAN
a) 1.7 lg/100 il
b) 1.6 mg/100 ml
c) 1.7 mg/100 ml
a) 535 or- 30 mg/day
b) 931 . or- 61 mg/day
c) 114 or- 20 ag/day
d) 757 or- 48 ig/day
e) 515 or- 27 mg/day
f) 896 or- 62 ig/day
g) 435 or- 58 mg/day
h) 795 or- 79 mg/day
GENE DAI IBFOIHiTION
a) Controls, non-natrient supplement
plus lactose-containing placebo
b) High protein-vitaain liguid
sapplenent plus linexal capsule 6
days/ilk
in b) plus 40 «g Zn as carbonate, 6
days/wk
Bacge of aeans over 20 tenths
No supplements during 4 BO suBaer
vaca tion
Significantly increased ht, vt, and
bone ages in boys receiving ZD during
final 12 mo of supplementation.
despite subnormal Zn levels in plasma
throughout study
study
13 yr old prepubertal village
schoolboys, southern Iran
IRAK; ADOLESCENTS; NUTRITIONAL
DEFICIENCIES: BLOOD PLASnA; BLOOD
•SEFBS: EBITHROCriES; C1LCIOK; ISOS;
EHOSPH080S; ZISC ; DIETS
a) 889 mg/day
b) 1313 mg/day
c) 928 mg/day
d) 1557 mg/day
e) 895 mg/day
f) 1345 mg/day
g) 920 mg/day
h) 1473 mg/day
Ketabolic research ward patients
ILLINOIS; UBINE; CALCIDB; FLUORIDE;
FBCSPBOBBS; (IETABOLISH
REFERENCE
Konagh;, H.A.
Reinhold, J.G.
Bahloudji, B.
Ghavami, P.
Spivey Fox, It. B.
1974
American Journal of
Clinical Satri tion
27(2): 112-121
Spencer, H.
Osist D.
Kramer, L.
Wiatrowski, E.
Norris, c.
1975
Journal of Hutritian
105:733-710
._
o
oo
-------
Piperazine,
Piperazine,
19216-56-9
C19-H21-H5-0
H« 362.12,
7339
Blood,
plasna
7310
Blood,
plasma
-(4-a«ino-6,7-ai«ethoxy-2-quinazolinjl)-4-(2-f«royl)- (8 CI)
- (4-aaino-6,7-diMethoxy-2-quinazolinyl)-4-(2-furanylcarboayl) - (9 CI)
278-280 C
EXPOSURE ROOTS
Injection
Ingestion
AMALTTICAL
BETHOD
HPLC
CC
Pluoroietry
N OH BEE
Of CASES
8
8
BAHGE
a) 23-48 ng/«l
b) 3.3-13.0 ng/il
c) 1.3-6.8 ng/»l
d) 4.9-11.4 ng/>l
e) 7.9-18.6 ng/.l
f) 11.3-33.0 ng/«l
g) 13.3-21.3 ng/«l
b) Hot applicable
a) Hot given
b) Hot given
c) Not given
d) Hot given
iEAH
a) Not given
b) 6.7 tor- 2.9 ng/mi
c) 3.3 +or- 1.8 ng/ml
d) 7.6 tor- 2.3 ng/al
e) 12.8 tor- 4.0
uq/ti
f) 20.5 tor- 8. 1
ng/il
g) 16.5 tor- 4.2
ng/»l
h) 30.0 ng/al
a) 6.2 tor- 0.9 ag/ml
b) 9.4 tor- 2.5 ng/jil
c) 20.3 tor- 3. 1
ng/nl
d) 37.1 tor- 6.9
ng/Bl
5.E.
GENERAL ISFOBfllTICH
a) Peaks, after 0-5 >g, IT, 1
patients, b) Peaks, 3-120 «in after
0.5 ng, oral, 8 patients
c) Steady-state level after 0.5 ig,
oral, 3x/d for 2 wk, 8 patients
d) Steady-state level after 1 ig,
oral, 3x/d for 2 ntc, 8 patients
e) steady-state level after 2 ig,
oral, 3x/d for 2 »k, 7 patients
f) Steady-state level after 3 ig,
oral, 3i/d for 2 wk, 5 patients
g) Steady-state level after 4 >g,
cral, 3jc/d for 2 »k, 3 patients
h) steady-state level after 5 «g,
oral, 3l/d for 2 wk, 1 patient
a) BstiBated fcoi graph
Untreated hypertensives, lit 70-110 kg
(lean 82.8 kg)
ADULTS; HIPEETEHSIOD; BLOOD PLASHA;
AHTIHIPESTEBSIVE AGEHTS; DEOG
THEEAPT; DEUGS
a) Dose 0.5 ag. AOC, 38 tor- 8
ng/»l/hr, 8 subjects
b) Dose 1 >g. AOC, 64 tor- 16
ng/Bl/hr, 8 subjects
c) Dose 2 «g. AUC, 169 tor- 30"
ng/«l/hr, 5 subjects
d) Dose 4 >g. AUC, 254 tor- 48
ng/nl/hr, 5 subjects
Hean peak levels 2 hr after dose
Seduced clearance in patients with
heart failure
Ht-67 yr old chronic heart failure
patients
Postural hypotension at doses of >1
•g, 3 patients
ADULTS; HEART DISEASES; BLOOD PLASI1A;
DRUG THE?HPT; DRUGS
REFEREHCE
Grahnea, A.
Seideian, p.
Liadstroi, B.
Haglund, 1C.
von Bahr, c.
1981
Clinical Pharsacology
and Therapeutics
30 (4): 439-446
silke, B.
Lakhani, 2.H.
Taylor, S.H.
1981
Journal of
Cardiovascular
Pharmacology 3:329-335
-C-
o
VO
-------
Fiperidine, ?-{ 1-phenylcyclohexyl) -
77-10-1
C17-H25-N
»» 2»3.38, HP 46 C, W 135-137 C at 1 •» Hg
73K1
Elood
7312
Blood
7343
Blood,
plasma
73»
-------
Eiperidine, 1-(1-phenylcyclohexyl)-
77-10-1
C17-H25-H
(IW 213.38, HP 06 C, BP 135-137 C at 1 11 Hg
(CONTINUED)
TISSUE
7305
orine
7306
Orine
7317
Orine
EXPOSURE ROOTB
Inqestion
Inhalation
Inqestion
Inhalation
AHAirTICAL
BETHOD
GC/ns
HI A
GC
HOflBEB
OF CASES
1
200
SINGE
1680-90 ng/ml
a) 0.1-100 ng/»l
b) Hot applicable
c) Hot applicable
d) Hot applicable
II Hot applicable
0.1-34 ug/»l
BEAU
Sot applicable
a) 13.5 nq/»l
b) 100 ng/al
c) 100 ng/Hl
dj 76 ng/Bl
£) 16 ng/al
0.5 ug/ml
GENERAL IHFOBHATION
Range foe varying urinary pH values
(<1.8-7.a),. Levels decreased with
increasing pfl. Data for 3.5 day
period starting 6 days after 500 mg
overdose. Total amount excreted
18 yc old
BICOD PLASMA; ORJHE; DRDG ABOSE;
DBOGS; PSYCHOTBOPIC DROt5S
a) 200 pateints (mostly teenagers)
with mild to severe psychotic
symptoms with or without acute
schizophrenia
salivating* bizarre BO venents. level
U3 hr later, 70 ng/«l
c) 16 yr old male, unmanageable.
10, 35 ng/»l and day 13, 25 ng/nl
d) 15 yr old aale, acute psychosis,
delusionary , used LSD, phencyclidine,
and aarMuana
e| t5 yr old male, disorderly and
silly behavior, serum negative for
phencyclidine
f) IS yr old female, strange
behavior, hypecacti ve, talkative,
pressured speech, serum negative for
phencyclidiae
violent, agressive behavior with
delusions, hallucinations, agitation.
ADOLESCENTS; BLOOD; URINE; DRUG
AEOSE; DRUGS
_ . .
24 of 26 samples positive. Exposure
to unknown anount by accidental
ingestion or inhalation of s»o*e in
antient air
Children, age 4-52 no (mean 16 BO)
with diagnosis of phencyclidine
intoxication, Ck
Dull, trance-like stare, agitation
alternating with lethargy, horizontal
ataxia. Additionally, some miosis,
hyper salivation, choreoathetoid
Bovements, diminish ed response to
pain, seizuces, signs of respiratory
depression. Sy mptoms lasted 1- 100 hr
(mild cases) and 16-200 hr (severe
cases) .
CALIFORNIA; CHILDREN; URINE; DRDG
ABUSE; DRUGS; PSYCHOTPOPIC DRUGS;
IBHALATION
REFERENCE
Domino, B.F.
Wilson, A.E.
1977
Clinical Pharmacology
and Therapeutics
Kaul, B.
Davidon, E.
1980
Journal of Clinical
20(89) : 500-505
Kacp, H.H.
Kaufman( H. D.
Anand. S.fC.
1980
97(6)11006-1009
(NEXT PAuE)
-------
Piperidine, 1-<1-phenylcycloheiyl)-
77-10-1
C17-H25-N
BW 2H3.38, »P 46 C, BP 135-131 C at 1 mm Hg
(CONTINUED)
TISSDE
73»8
EXPOSURE ROUTE
_
ANALYTICAL
METHOD
GC
N D« BEE
OP CASES
al 1
b) 1
RANGE
a) Nat applicable
.
BEAN
a) 15.95 ng/»l
GENERAL INFOBBATION
a) Handled PCP regularly, sample pH
b) No contact Kith PCP for 6 mo,
sample pH 6.3
officers, CA
CAtlFCRNIA; ADOLT5; BLOOD; OfilSB;
DEOG ABOSE; DFDGS; PSTCHOTBOPIC
DEOGS; FOBES; OCCOPATIOSA1 BAZASDS
BEFEREHCE
Pitts, F.».
Aniline, 0.
Tago, L.S.
1981
18(9): 1015-1020
Pipendinim, 1, 1 •- (Salpha, 17beta-dihydroiy-5alpha-androstan-2beta, ISbeta-ylene) bis (1-«etliyl-, dibronde, diacetate (8CI)
Eiperi4ini\i«, \, \<- ( (2beta,3alpha,Salpha, Hbeta, 17beta)-3,17-bis(acetTloxy)androstane-2, 16-diyl) bis (l-«etiyl-, aibroiide (9 CI)
15500-66-0
C35-B60-H2-0«.2Br
BS 732.70, IIP 215 C
TISSUE
7309
Blood
EXPOSURE HOOTE
_
Injection
ANALYTICAL
BETHOD
Fluoroaetr;
8DHBEB
OF CASES
1
BANGE
Not applicable
HEAN
1.6 .g/1
.
GENERAL INFOBBATICN
Estimated dose 10 mq, or 0.1U iq/Xq
Validity of levels questionable to
storage
Autopsy, 30 yr old, vt 73 Kg.
ADULTS; SUICIDE; DBUGS; MUSCLE
BILAXANTS; FORENSIC NEDICINE
Poklis, A.
Melanson, E.G.
1980
Journal of Analytical
Toxicology 1:275-280
N)
7100-09-7
At» 39.098, BP 63.2 C, BP 765.5 C, VP 100 mm Hg at 590 C
7350
Blood,
serum
EXPOSURE BOOTE
Ingestion
AHAUTICAt
HETHOD
HUM BEE
OF CASES
1
BANGE
Not applicable
BEAN
lit »Eq/l
GENEBAL INFOS NATION
Accidental ingestion of 8 Slow-K
tablets
Pcstmortem, 15 mo old
Vomiting, unconsciousness, cyanosis,
shallow respiration, quiet heart
sounds, peripheral circulatory
failure. Electrocardiogram shoved
atrial activity stopped, irregular
ventricular rhythm with grossly
elongated complexes.
AUTOPSIES; CHILDREN; BLOOD SEBUB;
DOTGS; POTASSKJB
Bacon, C.
197»
British Medical journal
1(590»):389-390
-------
Pregna-1,1-diene-3,11,20-trione,
53-03-2
C21-H26-05
H« 358.11, BP 235 C
17.21-dihydroxy-
TISSUE
7351
serun
_
ElfOSDBE BOOTE
Ingestion
ANALYTICAL
BETHOD
BIA
HOHBEB
OP CASES
16
E1HGE
a) 125. 14-321.1 ug/Bl x hr
o) 115.1-271.7 ng/al x hr
c) 151.0-297.9 ng/Bl I ht
d) 137.1-285.9 ng/Bl x hr
HEAX
a) 196.9 ng/il x hr
b) 194. 1 ng/Bl x hr
c) 217.2 ng/»l x hr
3) 213.3 ng/Bl x hr
GENERAL HFOBnATIOS
a) 5 mg predoisone (Oeltascne,
Dp^ohn)
b) 5 ng prednisolone
c) 5 ng prednisolone
d) 5 ag prednisolone
b) ,c) , & d) froB different Lots of
tablets (Delta-Cortef, Upjohn)
ADC data 0-12 hr after treatment
Healthy 18-55 yr olds, vt 52.2-83.9
kg
BIOOD SEEDS; i«TI-I»FLl»N»TOBY
JGENTS; DBIJG INTEBJCTIOH; DBUGS;
CCBPJBJTIVE EVALOATIOBS; flETABOUTES
Wagoer,
DlSanto
Gillesp
Albert,
1981
Besearc
in Chen
and Ph a
32(3):3
Pregna-1,1-aiene-3,20-dione, 1Ibeta,17,21-trihyaroiy- (8 CI)
Pregna-1, "t-diene-3, 20-dione. 11,17, 21-trihydroiy-, (1 Ibeta)- (9 CI)
50-21-8
C21-H28-05
n« 360.11, BP 210-211 C (decoBp)
TISSUE
7352
Blood,
serun
EIPOSDBE BOtJTE
lugestion
ANALYTICAL
BETHOD
BIA
HOUSES
OF CASES
16
BADGE
a) 389.3-1191 ug/Bl x hr
b) 113.5-1265 ug/Bl I hr
c) 361.5-1530 ug/Bl x hr
DEAD
a) 785. 1 ug/Bl x hr
b) 738.8 ug/»l x hr
c) 775.8 ug/Bl x hr
GENERAL IH FOBBATIOH
a) 5 ag prednisolone
b) 5 ag prednisolone
c) 5 Bg prednisolone
a) ,b) , and c) froa different lots of
tablets (Delta-cortef , Opjchn)
AOC data, 0-12 hr after treataent
Healthy 18-55 yr olds, vt 52.2-83.9
kg
BLOOD SF.BDB; ANTI-INFLAHHATOBY
AGENTS; DBOG ISTEBACTIOS; DBOGS;
CCSPABATIVE F.7ALOATIOHS; BF.TABOLITES
REFERENCE
Hagner, J.G.
DiSanto, A. B.
Glllespie, H.B.
Albert, K.S.
1981
Besearch COBBunicatlons
in Cheaical Pathology
and Pharaacology
32(3) :387-105
-------
Pregna-1,<4-diene-3,20-dione, 9-flnoro-l Ibeta. 17,21- trihydroiy- 16beta-«ethyl- (8CI)
Pregna-1, U-di.eae-3, 20-dioive, 9-f looco- It, 17,21-trihydcoxy-16-Bettiyl-, (1Ibeta,ISbetal - (9
378-OK-9
C22-H29-F-05
flV 392.«5, IIP 231-23H (dec)
TISSDE
7353
Blood,
fetal
EXPOSURE ROUTE
Injection
iSSLYTICAL
METHOD
Bit
BOBBER
OP C4SES
a) 14
b) 9
c| 18
d) 17
EANGE
a) Sot given
b) Not given
c} Hot given
d) Mot given
a) 8.6 +or- 0.9 ug
cortisol Sq/dl
b) 9.8 +or- 2.6 utj
cortisol Eq/dl
c) fc.8 +or- 1.0 ug
coctisol Eg/dl
d) 6. 1 +or- 0.9 ug
cortisol Eg/dl
GENERAL ISFORMATIOH
a) Hales. Hother received one or
nore 12 mg doses (as acetate and
phosphate)/ 12-21 hr. Delivery <2U
hr after 1st dose
I) Females. Sane as in a)
c) Males, Mother received 1 doses of
6 mg/12 hr. Delivery <60 hr after
first dose
d) Females. Sane as in c)
No significant differences
Premature infants, 751-1750 gm, CA
Incidence of respiratory distress
syndrome higher io Bales. Ho sex
difference in suppression of serua
cortisol, dehydrocpiandrosterone
sulfate, and growth hormone
CALIFORNIA; FETOS; HEHBORH; BLOOD;
DBUG THERAPY; DRUGS
BallarS, P.L.
Ballard, R.A.
Granberg, J.P.
Snidernan, 5.
Sluckean, P.D.
Kaplan, S.L.
Grunbach, M .1.
1980
Journal of Pediatrics
97(31 :H51-H54
Prizidilol (Ho postings in CHEfUINE).
TISSUE
735«
Blood,
plasma
EXPOS0BE ROUTE
Ingestion
HiLYTICSL
METHOD
BPLC
HUNBER
OF C»SES
6
BINGE
a) 0.09-0.21 ug/.l
b) 0.33-1.33 ug/«l
GEHEHAL IHFOHflATION
a) Hot applicable
b) Hot applicable
a) 1 and H hr after 6 ag/kq. Rapid
acetylator phenotype (3 subjects)
b) 1 and 3 hr after 6 mg/kg. 1.09
ug/nl at « hr. slow acetylator
phenotype (3 subjects)
Significantly higher in b)
Range of leans
24-66 yr old hypertensive patients
Systolic blood pressure decreased
after 3.0-6.0 ng/kgf diastolic
decreased after 4.5-6.0 «g/kg
ACOLTS; HYPERTEHSIOS; BLOOD PLASMA;
AHTIHYPERTENSIVE AGENTS; DROG
THEBAPT; DEDGS; BLOOD PFESS3RE
Larsson, R.
Karlberg, B.E.
Horlander, B.
Hirsen, A.
1981
Clinical Pharmacology
and Therapeutics
29 (5): 588-593
Propanamide, H- (1-(2- (»-et hyl-tt,5-dihydro-5-oro-lH-tetrazol-1-yl) ethyl) -4- (nethoxyaethyl) -1-p iperidinyl) -«-phenyl-
71195-58-9
C21-H32-H6-03
HH 416.59
| TISSUE
7355
Blood,
plasma
EXPOSURE HOOTB
Injection
ANALYTICAL
8ETHOD
GC
HOnBEB
0? CASES
1
BABGE
2230-7.6 ng/»l
HE AH
Not given
GEHEBAL ISFORIItTIOH
0-6 hr after 0.125 »g/kg body vt, IT
Estimated CCOM graph
ELOOD PLASH A; ANALGESICS; DRUGS;
HARCOTICS; HEASOREflEBT HETBODS;
BE1GIUB
EEFEEEBCE
noestenborghs, B.
Hichielsen, L.
Heykants, J.
1981b
Journal of
Chroaatography
22«t 122-127
-------
Propionanilide, N-(l-phenethyl-ft-piperidyl)-, citrate (1:1) (8 CI)
Propanamide, N-phenyl-H- (1- (2-phenylethyl) -ft-piperidinyl)-, 2-hvdroiy-l,2, 3-pr
990-73-8
990-73-8
C22-B28-N2-O.C6-H8-07
gt 528.95, BP 1H9-151 c
propanetricarboxylate (1:1) (9CI)
TISSUE
7356
Blood,
plasma
7357
Urine
EXPOSURE ROUTE
Injection
Injection
ANALYTICAL
METHOD
Radio* etry
Radiometry
HDHBEB
OF CASES
7
5
GAUGE
a) 16-2.5 ng/ml
b) 13-0.35 ng/ml
c) 3-1.3 ng/nl
a) Hot given
b) Hot given
__ -
MEAN
a) Hot given
b) Hot given
c) Hot given
a) 76X of dose
b) 8% of dose
GENERAL IHFORBATIOH
a) Total radioactivity
b) Radioactive fentanyl
c) Radioactive metabolites
Initial measurements and 8 hr after
6. ft ug/kg
Range of neaas, estimated from graph
Healthy 22-29 yr olds
BLOOD PL ASH A,; OR INF.; ANALGESICS;
DEUGS; HABCOTICS
a) Total radioactivity
b) Radioactive fentanyl
emulative 72 hr output after 6.
ug/kg
Healthy 22-29 yr olds
BICOO PUSFU; OEISE; ANALGESICS;
DRUGS; HARCOTICS
HcClain, D. A.
Bug, C.C.
1980
clinical Pharmacology
and Therapeutics
28(1): 106-11H
ncClain, D.A.
Hug, C.C.
1980
Clinical Pharmacology
and Therapeutics
28(1): 106-11»
Pyridine, 2- (p-chloro-alpha- (2- (dliethylanino) ethyDbenzyl) - (8 CI)
2-Pyridinepropananine, ganma-(t-chlorophenyl)-»,H-di«ethyl- (9 CI)
132-22-9
C16-H19-C1-H2
B« 27H.80, BP 130-135 c (Allergisan), BP 1»2 C at 1.0 u Hg
TISSUE
7358
Bile
7359
Blood
EXPOSURE ROUTE
ANALYTICAL
HETHOD
GC
GC
HUKBEB
OF CASES
.
1
1
EAHGE
Hot applicable
Hot applicable
BEAH
1.5 »g/l
1 . 1 ng/1
GEHERAL IHFORBATIOH
fatal ethanol and chlorpheniranine
overdose
roadside, age early 20's, wt 150 Ib,
CA
Pulmonary edera, congestion of liver
spleen, kidneys
CALIFORNIA; AUTOPSIES; BILE; BLOOD;
ERAIN; KIDNEYS; LIVES; tUHGS; DRUG
ABUSE; DRUGS; FORENSIC BEOICINE
fatal ethanol and chlorpheniranine
overdose
roadside, age early 20 's, wt 150 Ib,
CA
Pulmonary edema, congestion of liver
spleen, kidneys
CALIFORNIA; AUTOPSIES; BILE; BLOOD;
EEAIH; KIDNEYS; LIVER; LUHGS; DRUG
ABUSE; DRUGS; FORENSIC BEDICINE
REFERENCE
Reed, D.
1981
Clinical Toricology
18(8) :9itl-9»3
Reed, D.
1981
Clinical Toxicology
18 (8) :9»1-9H3
(NEXT PAGE)
-------
Pyridine, 2- (p-chloro-alpha- (2- (diiethylaiino) ethyl) benzyl) - (8 CD
2-Pyridinepropanaaine, gamBa- (4-chlorophenyl)-N,N-diBethyl- (9 CI)
132-22-9
C16-H19-C1-B2
tin 270.80, »P 130-135 C (Allergisan), BP 142 C at 1.0 •• Hg
(CONTINUED)
•TISSUE
7360
Blood,
seruB
7361
Brain
7362
Kidney
7363
Liver
7361
lung
EXPOSURE ROUTE
Infection
II1LYTICAL
HETBOD
t
cc/as
sc
GC
GC
GC
NDBBEE
OF CASES
1
1
1
1
1
BINGE
118-4.2 ng/»l
Mot applicable
Not applicable
_
Not applicable
_
Hot applicable
HEAR
Hot given
2.5 ig/kg
1.4 ng/kg
6.6 ng/fcg
5.2 »g/kg
GENERAL mFOR»ATION
0.25 and 24 hr after 0.10 ig/kg
Pharmacokinetic data for 6 other
children also given
Estimated froa graph
11 yr old, »t 57 kg, vlth chronic
rhinitis
CHILDREN; BLOOD SERUH: AOTOHOHIC
DRDG5; DRUGS; JHTIH ISTABIHE
fatal ethanol and chlorpheniranine
overdose
roadside, age early 20 fs, wt 150 Ib,
CA
Palaonary edeia, congestion of liver,
spleen, kidneys
CALIFORNIA; AUTOPSIES; BILE; BLOOD;
ERAIN; KIDNEYS; LITER; LONGS; DRUG
ABUSE; DSOSS; FOSE«SIC HEDICUE
Fatal ethaool and chlorpheniraMine
overdose
roadside, age early 20
-------
Fyridoxal, 5-{dihydrogen phosphate (8 CI)
4-Pyridinecarboxaldehyde, 3-hydroxy-2-nethyl-5- ((phosphonooxy) Bethyl) (9 CI)
50-47-7
C8-H10-B-06-S
BV 207.15, HP 1(0-1113 C
TISSUE
7365
Blood,
plasaa
EXPOSURE E001E
AHALTTICAL
IETROD
«o«:
OF CI
a) 4
b) 9
c) 10
d) 9
e) 10
f) 1
•OlBEB
OF CASES
a) 4
b) 9
c) 10
9) 9
e) 10
f) 1
BARGE
-
a) Hot given
b) 2.8-9.2 ng/Bl
c) 1.6-9.8 ng/Bl
d) 23.0->58.6 ng/Bl
e) 3.2-X0.4 ng/Bl
f) Hot given
g) Hot given
a) 16
b) 4.
c) 3.
d) 28
ng/Bl
e) 12
Bg/Bl
f) 10
g) >
BEAH
.9 ng/Bl
3 ng/nl
3 ng/Bl
.4 tor- 9.8
.2 tor- 4.5
.6 ng/nl
60 ng/Bl
GEHERAL IHFORBATIOR
a) Honpregnant vo»en, 20-34 vc old
b) Hocmal pregnant vonen, prior to
delivery
c) Pre-eclaiptic voBen, prior to
delivery
d) Infants fro» normal pregnancy,
cord blood
e) Infants froa pre-ecla«ptic
aethers, cord blood
£) MoL'nal pregnant voaan snppleaented
with pyridozine, 5 Bg/dav, 63 days
latter half of pregnancy
g) cord, woBan in f)
Obstetrical patients, Texas
TEJX5: ADOllS; HEHBOBH; RIPEBTENSIOS;
BEKTSL KET»BD»TIO»; IDTRITIOITtl
CEflCIEKCIES; BLOOD PLASHa; VITtKIHS;
ELOOD PBESSUBE; PBEGNtHCT
Brophy, n.u.
Siiteri, P.
1975
&Berican Journal of
Obstetrics and
Gynecology
121(8) : 1075-1079
Quinidine (8 CI)
cinchonan-9-ol, 6'-Bethoiy-, (9S)- (9 CI)
56-50-2
C20-H24-B2-02
B» 321.41, HP 171-175 C
7366
Blood,
seruB
EXPOSUEE BOUIE
Ingestion
AHHYTIC1I
flETHCD
BPIC
NOB BEE
OF CtSES
1
BABGE
0.85-0.35 Bg/1
fiEAH
Hot given
GEHEBAL IHFOBHATIOH
3 and 8 hr after 200 »g as sulfate,
0.38 »g/l at 1 hr
Estimated froB graph
HEABT DISEASES: BLOOO SEBDB;
AKTURPBrTBKIC AGESTS; CROG THEBAPI;
DEUGS: HEASUBHIEHT KETHODS
EEFEBEHCE
Crouthaiel, H.G.
Kouarski, B.
Harang, P.K.
1977
Clinical Cheaistry
23(11) .-2030-2033
Cuinine (8 CI)
Cinchonan-9-ol, 6<-Bethoiy-, (8alpha,9B)- (9 CI)
130-95-0
C20-H21-H2-02
I« 321.16
TISSUE
7367
Blood
EXPOSURE ROUTE
ANALYTICAL
flETHOD
0V
HUBBEB
OF CASES
a) 7»
b) 112
BADGE
a) 0.4-9.9 ng/dl
b) 0.5-11 ug/dl
DEAH
a) Hot given
b) Hot given
GEIEBAL IHFOBBATIOH
a) Deaths involving Borphine and
qainine
b) Deaths involving Borphine,
ethanol, and qaioine
Rayne County, HI
HICHIGAH; AUTOPSIES; DBUG ABUSE;
DBUGS: HAECOIICS; PSTCHOTBCPIC DRUGS;
SEDATIVES
BEFEBEHCE
Bonforte, J.B.
1977
Journal of Forensic
Sciences 22 (») :7 18-72*
-------
Quinoline, 7-chloro-t|-< (it- (diethylaaioo) -1-aet hylbutyl|a«ino) - (8 CI)
1.1-Pentanediamine, H (U) - (7-chloro-»-quinolinyl)-N (1) , N (1) -Uetfcyl- (9 CI)
SK-O?-?
C18-H26-C1-N3
HH 319.89, BE 87 C
TISSUE
7368
Blood
7369
Kidney
7370
liver
7371
lung
EXPOSURE POOTE
ANALYTICAL
dETHOD
GC
GC
GC
GC
NOHBEB
0? CASES
1
1
1
1
RANGE
Not applicable
Hot applicable
Mot applicable
..
Not applicable
(KBIT
BEAN
33 ug/»l
110 ug/g
169 ug/g
73 ug/g
PAGE)
GENERAL INFOBBATION
Suicide »ieti«, dose unknown
15 yr old Laotian, resident of San
Jose, CJ
Cerebral edena with anoxic cortical
reaction, pulnonacy congestion and
edena, heoorrhagic gastritis
ClLIrOEBIl; VJTOSSIES; SUICIDE;
BLOOD! KIDNEYS; LI7E8; LOHGS; ORINE;
»NTI-I»FLA!!9»TORY AGEHTS;
ASTIAEEHJTHIIIC AGENTS; DBOG ABUSE;
OEDGS; FOBEKSIC OEDICINB
Suicide victia, dose unknown
Jose, CA
Cerebral edeaa with anoxic cortical
reaction, pulnonary congestion and
edena, emorrhagic gastritis
CALIFOEBIA; AUTOPSIES; SOICIOE;
BLOOD; KIDSETS; L1»E8; LONGS; OBIIIE;
8»TI-I»FL»fl»ATOBY AGENTS;
ABTIABPHyTHBIC AGENTS; DBOG ABUSE;
DEDGS; FOBENSIC BEDICISE
Suicide victia, dose unknova
15 yr old Laotian, resident of San
Jose, CA
Cerebral edeaa with anoxic cortical
reaction, pulaonary congestion and
edeaa, heaorrhagic gastritis
CALIFOB»IA; ADTOPSIES; SOICIDE;
BLOOD; KIDNEYS: LITEB; LtJHGS; OBINE;
ANTI-INFLAHBATOBY AGENTS;
ANTIABBHYTHHIC AGENTS; DBOG ABOSE;
DETCS; FOBEHSIC (1EDICIBE
Suicide victia, dose unknown
15 yr old Laotian, resident of San
Jose, CA
reaction, pulaonary congestion and
edeaa, a&d heaorrh&gic gastritis
CALIFORNIA; AOTOPSIES; SOICIDE:
BLOOD; KIDNEYS; LI7EB; LONGS; DBINE;
ARTI-INFLAflBlTOBI AGE8TS;
ABTIABBHYTHBIC AGENTS; DBHG ABOSE;
DBOGS; FOEEBSIC HEDICINE
B8FEBE8CE
Ueingarten, H.L.
Cherry, E.J.
1981
Clinical Toxicology
18(8) :959-963
Heingarten, fl. L.
Cherry, E.J.
clinical Toxicology
18(8):959-963
Reingarten, H.L.
Cherry, E.J.
1981
18 (8): 9 59-963
Heingarten, H.L.
Cherry, E.J.
1981
clinical Toxicology
18{8):959-963
00
-------
Cuinoline, 7-chloro-4- ((4- (diethylamino) -1-methylbutyl) amino) - (8 CI)
1,4-Pentanediamine, N (1) - <7-chloro-4-guinolinyl) -N( I) , K(1) -dlethjl- (9 CI)
EU-05-7
C18-B26-C1-N3
MH 319.89, HP 87 c
(CONTINUED)
7372
Urine
EXPOSURE ROUTE
ANALYTICAL ,
BETHOD
GC
NOflBER
OF CASES
Mot applicable
367 Uq/»l
GENERAL INFOHBATION
Suicide victim, dose unknown
15 yr old Laotian, resident of San
Jose, CI
Cerebral edema with anoxic cortical
reaction, pulmonary congestion and
edema, and aemorrhagic gastritis
CAIIFORBIA; AUTOPSIES; SOICIDE;
BLOOD; KIDHEYS; LIVES; LUBGS; URINE;
ABTI-IBFLABMAT08Y AGENTS;
ABTIARPHYTHSIC AGEHTS; DRUG SBOSE;
DRUGS; FORENSIC HEDICINE
Heinqarten, H. L.
Chercy, E.J.
1981
Clinical Toxicology
18(8( :959-963
Resorcinol (8 CI)
1,3-Benzenediol (9 CI)
108-46-3
C6-B6-02
HW 110.11, HP 109-111 C, BP 280 C (also reported as 276.5 C) , VP 1 na ag at 108.4 C
TISSUE
7373
Urine
EXPOSURE ROUTE
Dermal
ANALYTICAL
METHOD
HPLC
N 0.1 BEE
OF CASES
a) 3
b) 1
RANGE
a) 3.75-22.98 mg
b) 0 mg
MEAN
a) 13.13 mg
b) 0 mg
GENERAL INFORMATION
a) 24 hr sample after 2 weeks of 800
mg/day, topical application
b) Untreated control
OBTOS; BEASUEEMBST BETHODS
REFERENCE
Yeung, D.
Nacht, S.
Gans, E.H.
1981
Chromatography
224: 513-518
Salicylic acid (8 CI)
BenToic acid, 2-rydroxy- (9 CI)
65-72-7
C7-H6-03
He 138.12, HP 157-159 C, BP about 211 C at 20 mm Hg
TISSUE
73711
Blood,
plasna
EXPOSURE ROUTE
Ingestion
ANALYTICAL
METHOD
NUflBEE
OF CASES
a) 1
b) 1
a) 35-2.5 ug/»l
b) 45-1.0 ug/nl
a) Not applicable
b) Not applicable
GENERAL IHFORHATIOK
a) 1 and 12 hr. Initial measurement
29 ug/nl at O.S he
b) 1 and 12 hr
Bstinated from graph
Dose 1*5*1 mg, plus 32t ng phenacetin,
64 mg caffeine, and 60 mg codeine
phosphate
30 and 32 yc old nursing mothers
ADULTS; BLOOD PLUSHi; MILK;
HHALGESICS; DRDGS; NARCOTICS;
CAFF5INE; LACTATION
REFERENCE
Findlay, J.K.A.
DeAngelis, R.L.
Kearney, H.F.
Vlelch, R.B.
Findlay, J.».
19S1
Clinical Pharmacology
and Therapeutics
29(5) :625-633
(BEIT PAGE)
-------
Salicylic acid (B cl)
Benzoic acid* 2-hydroxy- (9 CI)
69-72-7
C7-H6-03
US 138.12, HP 157-159 C. BP about 211 c at 20 aa eg
(CONTINUED)
7375
Blood,
serun
7376
Hilk
EXPOSOBE HOQTE
Demi
Ingest ion
, , ,,
ANALYTICAL
METHOD
HPLC
. .
NUMBER
OF CASES
1
a) 1
b) 1
BINGE
670-84 ag/1
a) 0.27-1.0 ug/ll
b) 1.5-0.2 ug/al
SEAN
Not applicable
a) Hot applicable
b) Hot applicable
GENEBAL IN FOP NATION
Day 1 and 3 after 150 g/day for 4
days as a 10V ointaent.
Detoxification began on day 2.
7 yr old with congenital ichthyosis.
The Netherlands
Hyperventilation, hyperpyrexia and
coaa. Brain edeaa, coagulopathy and
netabolic acidosis. During the weeks
following treatment, patient was
hypertonic, opisthotonic and
exhibited extension spasas. EEG
abnornalities and paroxysaal brain
stea disorders.
CASE HISTORIES; CHILDREN; BLOOD
SEK01; ANALGESICS; ANTI-INFLAMB ATORY
•GENTS; DBDGS; NETHERLANDS
a) 0.5 and 2 hr after 454 ag. Final
neasureaent 0.8 ug/Bl at 12 hr
b) 1.5 and 24 hr after 454 ag.
Initial measureaent 0.9 ug/al at 0.5
hr
Estiaated froa graph
lose included 32" ag phenacetin. 64
•g caffeine and 60 a? codeine
phosphate
30 and 32 yr old nursing aothers
ADULTS; BLOOD PLASMA; BILK;
AHALGESICS; DROGS; HARCOT1CS;
CAFFE1HE; LACTATIOS
REFEBEUCE
ages, D.E.A.
Bloeahof. H.
Christensen, E.E.J.
1981
Pharaaceutisch Reekblad
Scientific Edition
3:205-211
Findlay, J. ».».
DeAngelis, R.L.
Kearney* H.F.
Welch, B.B.
Findlay, J. n.
1981
Clinical Pharaacology
and Therapeutics
29 (5):625-633
fo
o
Salicylic acid acetate (8 CI)
Benioic acid, 2-(acetyloxy)- (9 CI)
50-78-2
C9-H8-OU
US 180.2, BP 135 C
TISSUE
7377
Elood,
serua
EXPOSURE ROUTE
.
ANALYTICAL
METHOD
BPLC
HOHEEB
OF CASES
63
-
BANGE
a) 20-308 ag/1
b) 0.3-12.1 ag/1
c) Dot given
d) Not given
e) Mot given
f) Hot given
g) Hot given
DEAN
a) Not given
b) 3.8 ag/1
c) 5.6 ag/1
d) 4.3 ag/1
f) 5.3 ag/1
g) 9.5 ag/1
GENERAL INFORHATIOM
a) Salicylic acid, 62 patients
d) Salicyluric acid, 63 patients
c) Salicyluric acid, 7 patients in b)
<30 yr old
d) Salicyluric acid, 5 patients in b)
30-39 yr old
e) Salicylnric acid, 9 patients in b)
40-49 yr old
f) Salicyluric acid, 12 patients in
t) 50-59 yr old
g) Salicyluric acid, 10 patients in
b) >60 yr old
Metabolites of salicylic acid acetate
c)-g) patients with salicylic acid
levels >1OO ag/1, estiaated froa
graph
Patients on chronic acetylsalicylic
acid therapy
ADULTS; RHEOBATOID, AKTHRITIS; BLOOD
SEROII; ANALGESICS; ANTIPYRETICS; DRUG
THERAPY; DROGS; BETABOLITES
Hontgoaery, P.R.
Sitar, D.S.
1981
Gerontology 27:329-333
-------
Salicylic acid, ioo(l-) (8 CI)
Benzole acid, 2-hydroxy-, ion(l-) (9 CI) (Til)
63-36-5
C7-H5-03
n( 136.12, HP 157-159 C, BP about 211 C at 20 » Hg
TISSUE
7378
Blood,
serui
7379
Blood,
serum
7380
nilk
EXPOSURE ROUTE
Ingestion
Ingestion
Ingest ion
ASALTTICAL
METHOD
BPLC
HOHBEB
OF CASES
1
20
6
BADGE
59-12 mg/dl
a) Hot giren
b) Not given
c) Hot giyen
a) 0.42-0.78 mgX
b) 1.20-2.11 mgX
c) 1.80-1.81 mgX
«EAN
Hot given
a) 143. 1 ug/ml
b) 131.9 ug/»l
c) 138.9 ug/ml
a) 0.58 mgX
b) 1.60 mg<
c) 3.87 mgX
GENERAL INFOBSATIOH
Initial measurement and 2 days after
52 yr old
Mental agitation and confusion.
labored respiration, bilateral rales
vith expiratory nheezes in lover
parts of lungs. Deep tendon
hyperreflexia, minimal acrocyanosis,
tachycardia. Pulmonary edema.
CASE HISTORIES; BLOOD SBROB;
ANALGESICS; CHUG ABOSE; OR OGS
a) Plain aspirin
b) Buffered aspirin
Dose 3.9 g/day for 7 days
Healthy 21-15 yr olds
Submucosal hemorrhages after plain or
buffered aspirin
BLOOD SEBUS; ANALGESICS; DBDG
THERAPY; DRUGS
a) 2-1 hr after 500 >g
b) "2-6 hr after 1000 «q
c) 2-1 hr after 1500 «g
Administered as 500 ig acetysalicylic
acid tablets 1 hr after breakfast
Peak levels
Healthy nursing mothers, 21-32 yr old
(mean 29 yr) , 16-65 kg (mean 58 kg),
2-6 no post-partua (mean 5 mo)
ADOLTS; BILK; ANALGESICS;
AHTIPIRETICS; DRUGS; LACTATION;
METABOLITES
Liebman, E.B.
Katz, H.H.
1981
Journal of the American
nedical Association
206(19):2227-2228
Lanza. F.L.
Royer, G. L., Jr.
Nelson, R.S.
1980
New England Journal of
Kedicine 303(3):136-138
Jamali, F.
Keshavarz, E.
1981
International Journal
of Pharmaceutics
8:285-290
-p-
N5
Sulfuric acid atsodium salt
7757-62-6
B2-01-S.2Na
KB 112.06, BP approximately 800 c
TISSUE
7381
urine
EXPOSURE ROUTE
Ingestion
lltlLTTICIL
HETHOD
Colorimetry
« US BEE
OF CASES
5
BADGE
a) 13.0-25.0 m.oles/24 hr
b) 17.3-55.2 mmoles
c) 38.8-71.5 mmoles
d) 27.9-59.8 mmoles
e) 50.8-69.3 mmoles
a) Not given
b) 36.4 +oc- 15.4
Dholes
C) 53.4 +or- 15.8
OBOles
d) <*3.5 +or- 12.0
••oles
e) 61.8 +or- 7.8
••oles
a) Baseline
b) 24 he output after 18.1 g as
decahydrate
b) 72 hr emulative output after 18.1
g as decahydcate
d) Saie as b) , 4 equally divided
hourly doses
e) Saie as c) , 4 equally divided
hourly doses
Healthy volunteers
Severe diarrhea after single dose.
Ho diarrhea or only aild cases of
short duration after multiple sialler
doses.
SDLFATE;
; DKIGS
Cocchetto, O.M.
Levy, G.
1981
Journal of
Pharmaceutical Sciences
70(3) :331-333
-------
Tctrahydrocannabinol cross-reacting cannabinoids (Bo postings in CHEHLINE).
TISSUE
7382
nrine
7383
Urine
EXPOSURE ROUTE
Ingestion
Inhalation
Inhalation
ANALYTICAL
BETHOD
Hoaogeneous
Enzyae laaunossay
NUBEEE
OF CASES
7
a) 1
b) 1
BAHGE
a) 132-918 ug/1
b) 561-363 ug/1
c) 63-118 ug/1
d) Hot detectible
e) 128-705 ug/1
f) 100-800 ug/1
a) Hot given
b) Not given
HE AN
a) Not give
b) Not give
c) Hot give
d) Not give
e) Not give
f} Hot give
a) 60 ng/al
b) >250 ng/al
GEHIRAL ISFOR8ATI011
a) 2 and 6 hr after 30 ag delta-9
tetrahydcocannabinol (TRC
at 24 hr. Predose level
subject)
b) 6 and 18 hr after 30 •
THC (1 subject)
c) 2 and 18 hr alter 100
cannabidiol. Predose lev
(1 subject)
d) 100 ng cannabidiol (1 subject)
e) 2 and 12 hr after 100 Eg
cannabinol (1 subject)
£) Peak levels 1-5 hr >
•arijuana cigarette (4 subjects)
levels expressed as THC-9 acid
OBINE; DBUGS; PSYCHOTROPIC DROSS;
BEASOREBEHT METHODS
cigarette (20 ag delta-9
tetrahydrocannabinol) (THC)
b) 5 hr after a stani
cigarette. Specific
ORIHS; DRUGS: PSICHOTROPIC DRUGS;
1EASOBEBEHT HETHODS
tlOll
1 delta-9
) . 311 ug/1
216 ug/1 (1
g delta-9
•g
el 132 ug/1
subject)
ag
er stoking 1
bjects)
acid
frott graph
c DROGS;
•arijuana
C)
•arijuana
y found 2 1
-delta-9 THC
C DRUGS;
ECTEHEBCE
Rodgers, R.
Croirl, C.P.
Eiistad. V.fl.
Hu, n.v.
Kai, J.K.
Ronald, R.C.
Rowley, G. L.
Oll»an,-E.r.
1978
Clinical Cneiistry
21(1) :95-100
Gross, S.J.
Soares, J.I.
1978
Journal of Analytical
Toticology 2:98-100
(8 CI)
1H-Purine-2,6-dione, 3,7-dihydro-1,3-di»ethyl- (9 CI)
58-55-9
C7-H8-HH-02
BB 180.17, BP 270-27t( c
K3
7381
Blood,
plasma
7385
Blood,
plasia
EXPOSOHE EOOTE
Ingestion
Injection
1BALITICXL
HETHOD
HDHBEB
OF CASES
a) 9
b) 8
a) 1
b) 1
c) 1
BAHGE
a) 3.5-6 »g/l
b) 6-9. 8 >g/l
a) 21-13 ug/il
b) 1H-6.5 ug/»l
c) 7-3.8 ug/ll
HEAN
a) 4.8 »or- 0.7 ng/j.
b) 8. 1 «or- 1 . 1 »g/l
a) Hot given
b) Not given
c) Not given
SESERAL IHFORB1TION
a) Stokers (1 Hen, 5 woven)
Saaples collected over 8 hr period
Range of Means estimated fro* graph
In cigarette saokers H-denethylation
increased aore than B-hydroxylation
61. tt kg. Nonsaokers, aean age 29.7
yr, nean wt 60.3 kg
ADULTS; BLOOD PLASHA; ORIHE; DRUG
THERAPY; DRUGS; BOSCLE BELAXAHTS;
THEOPHTLLINES; BETABOLISB;
BETABOLITE5: SBOKIHG
a) 30 and 360 ain after 3.2-5.3
ag/kg. Initial aeasureaent 17 ng/al
at 15 ain
b) 30 and 360 ain after 3.2-5.3
ag/kg. Initial aeasureaent 7.3 ug/al
at 15 ain
c) 30 and 300 ain aftei. 3.2-5.3
ag/kg. Initial aeasureaent 6.8 ug/al
at 20 ain
Estiaated froa graph
24-32 yr old astfeaatics
BLOOD PLASBA; BILK; DRUGS; AUTOHOHIC
DSOGS; DIURETICS
BEFEREHCE
Grygiel, J.J.
Birkett, D.J.
1981
Clinical Pharaacology
and Therapeutics
30(4) :491-496
Stec, S.P.
Greenberger, P.
Rao. T.I.
Henthorn, T.
Horito, T.
Atkinson, A.J. , Jr.
Patterson, B.
1980
Clinical Pharaacology
and Therapeutics
28(3) : 104-1 08
(HER PAGE)
-------
Theophylline (8 CI)
1B-Purine-2.6-dione. 3.7-dihyaro-l,3-di»ethyl- (9 CI)
56-55-9
C7-B8-HH-02
B« 180.17, HP 270-271 C
(COHTIHOEO)
TISSOE
7386
Blood,
plaSBa
7387
Bilk
7388
Drine
EXPOSOBE BOOTE
Ingestion
Injection
Ingestion
ANALYTICAL
BETHOD
GC
HPLC
HPLC
HtfflBEB
OF OSES
1
a) 1
b) 1
c) 1
a) 9
b) 6
RINSE
a) Not applicable
b) Not applicable
c) Hot applicable
a) 12-6.5 ug/Bl
b) IO-it.5 ug/Bl
c) 5.7-2.7 ug/Bl
a) Hot given
b) Hot given
BEAU
a) 146 ag/1
b) 98 ag/1
c) 31 ag/1
a) Mot given
b) Hot given
c) Not given
a) 99.5 »or- 1.6S
b) 103 »or- 5.3t
GEHCTAL IHTOBHITIO»
a) 16 hr after aose
b) At start of charcoal heiopecfasion
c) After 3 hr heaoperfasion
Dose 1,575 g
15 yr old, OR
Hypotension, tachycardia,
carflio-respiratory arrest
(resuscitated), acidosis,
hypokaleiia, hypocalcelia, cardiac
arrhythmias, convulsions
OHITED FISGDOM; JOOLESCEBTS; ADULTS;
CASE BISTOEIES; BLOOD PLASRA: DBOS
AEOSE; DEOGS; HYPBOTICS; 1IOSCLE
8ELAXAHTS; TBEOPByLLISES
a) 30 and 330 (in after 3.2-5.3 ig/kg
b) 30 and 330 (in after 3.2-5.3 13/kg
c) 30 and 300 «in after 3.2-5.3 «g/fcg
21-32 yr old asthaatics
BLCOD PLAS3J; BILK; DBOGS; AtJTONOBIC
DEDGS; DIDBETICS
a) Saokers (4 Ben, 5 voien)
3) Nonsnokers (1 Ben,
-------
Theophylline, co»pd. with ethylenediaiine (2:1) (8 CI)
1H-Purine-2,6-dione, 3,7-dihydro-1,3-di»etliyl-, coipd. Kith 1.2-ethanediaiine (2:1) (9 CI)
317-34-0
C7-H8-H4-02.1/2C2-H8-H2
B« 420.44. BP 276-278 C
7389
Blood,
plasaa
EXFOSOBE ROUTE
Ingestion
ANALYTICAL
METHOD
HPLC
NUMBER
OF CASES
11
BADGE
a) Mot given
b) Hot given
c) Hot given
«} Sot given
f) Hot given
g) Mot given
i) Not given
j) Hot given
HBAH
a) 5.6 *or- 1.8 ug/il
b) 5.5 »or- 2.0 ug/Ml
c) 11.8 «or- 3.5
6) 13. 1 »or- 5. 3
ug/»l
e) 12.5 *or- 4.9
f) 15.5 +or- 7.2
vig/al
g) 11.5 *or- 4.2
h) !«.« *or- 6.2
ug/»l
i) 12.5 «or- 4.7
ug/»l
ug/»l
GEHEGtL INFORBATICN
a) Day 1, 2 hr after licrocrystalline
for*
b) Day 1, 4.5 he after
c) Day 2, 2 hr after nicrocrystalline
fo»
d) Day 2, 4.5 hr after
e) Day 3, 2 hr after Macrocrystalline
£cr«
f) Bay 3, ».5 hr after
g) Day 4, 2 hr after Microcrystalline
fori
h) Day «, 4.5 hr after
sustained-release fora
fora
j) Day 5, 4.5 hr after
nicrocrvstalline dose of 187.5 «g
375 mq every 12 hr, over 5 days
Healthy 20-35 yr olds. Northern
Ireland
Sleep difficulties, headache, nausea,
treaors, voiiting, diuresis, aalaise,
agitation, loss of appetite.
IBH.&ND; A DOLTS; BLOOD PLiSHi; DRtJGS;
RQSCLE ?ELAIANT3; COMPIiRATIVB
EVALOITIOITS; THEOPHrillHFS
Bussell, C.J.
El«00d, K.K.
Kinney, c.
ncDevitt, D.s.
1980
European Journal of
clinical Pharmacology
18:351-354
TkeophylUne, 7- (2, 3-dihydrojypropyl) - (8 CI)
lB-Purine-2,6-dione, 7-(2, 3-dihydroiypropyl)-3,7-dihydro-1,3-4i»ethyl- (9 CI)
479-18-5
C10-B14-S4-04
US 254.25, IIP 158 C
TISSUE
7390
Blood,
serai
EIPOSOPE ROD1E
_ _
Injection
4H4LITIC1L
HETHOD
HPLC
KDBBEG
OF OSES
20
EDGE
6.3-16.8 ug/ll
_
MEAN
10.7 +or- 3.1 ug/Hl
GEHEEJI. IRFOBHtTIQH
Initial level (extrapolation to ti«e
0) after 5 ig/Jig
Peaks reached vithin 2 hr, peaks in
lilk nithin 2-4 hr
ililk to serui ratio, 2.08 »or- 0.52
Lactating 20-35 yr olds, Kentucky
KE«T
-------
Thioxanthene-delta(9, gaiaa)-propvlanine, 2-chloro-»,H-(li«et«yl-, (Z)- (8 CI)
1-Propana»ine,3-(2-chloro-9H-thioxaathen-9-ylidene)-1l,N-di«etIiyl-, (Z)- (9 CI)
113-59-7
Cie-HlB-Cl-S-S
fl» 315.9, IIP 91-95 C
7391
Brain
7392
liver
ABlirTICiL
METHOD
GC
UT
GC
ov
NOBBEB
0? OSES
1
1
BAHGE
a) Hot applicable
b) Hot applicable
a) Hot applicable
b) Hot applicable
HEAH
a) O.e mg/IOOg
b) 0.4 19/1009
-
a) 0.8 ag/IOOg
b) 1.0 ng/IOOg
GBIERAL IHFORBATIOH
a) Solvent extraction vethod
b) XAD-2 resin bag extraction aethod
Poland
POLAND: BLOOD; BRAIN; LIVER; DRUG
tEUSE; DROGS; BEASOREBENT SETBODS
a) Solvent extraction aethod
b) XAD-2 resin bag extraction aethod
Fatal overdose case
Poland
POLAND; BLOOD: BRAIH; LIVSR; DEOG
ABUSE; DSOGS; BEASDREnEHT BETHODS
BEFEBEBCE
Sffgasz, B.
Gierz, J.
1978b
Forensic Science
International 12:73-32
Bogusz, B.
Gierz, J.
Bialka, J.
1978b
Forensic Science
International 12:73-82
Tryptophan, 5-hydroxy-, L- (8 CI)
1-Tryptophan, 5-hydroxy- (9 CI)
1350-09-8
C11-H12-H2-03
B« 220.23, BP 270 C (dec.)
7393
Elood,
plasna
EXPOSURE ROUTE
Ingestion
ANALYTIC \i
BETHO:
HPLC
Fluoroaetry
HOB BEE
OF CASES
15
GAUGE
a) 0. 15-0.40 uiol/1
b) 1.6-3.6 UKJl/1
c) 1.7-3.7 u»ol/l
d) 1.6-2.8 uiol/1
e) 3.0-5.0 u.ol/1
f) 2.2-9.3 u»ol/l
g) 2.9-5.8 uiol/1
DEAN
a) Not given
b) Hot given
c) Not given
d) 2.4 UBOl/1
e) 3.9 o»ol/l
f) Not given
g) Hot given
GEHFBAL IHFORBATIOH
a) 0.5 and 2 hr after 2 ng/tcg. Final
neasureaent 0.25 onol/1 at 8 hr (3
patients)
b) 0.5 and 2 hr after 2 ig/kq. Final
teasareeent 1.8 u»ol/l at 8 hr.
After 50 «g carbidopa daily for 14
days (3 patients)
c) 0.5 and 2 hr after 2 «g/kq. Final
•easurevent 1.7 uaol/1 at d hr. Vith
50 mg carbidopa (3 patients)
d) Peaks 0.5-5 hr after 50 «g »ith 50
•g cardidopa (6 normal subjects)
e) Peaks 0.5-4 hi after 100 ig >ith
50 »g cardidopa (6 ncraal subjects)
f) Peaks 1-3 hr after 50 mg with and
without 100 ng L-dopa and 25 Kg
fcenserazide (6 parkinsonian patients)
g) Peaks 1-7 hr after 50 »
-------
Oracil, 5-fluoro- (8 CI) (VAN)
2,11 (1H,3H)-PyriBidinedione, 5-fluoro- (9 CI)
51-21-8
C4-H3-F-H2
SB 130.08, lit 282-283 C (decoip)
Blood,
plasaa
EXPOSURE ROUTE
Infection
ANALYTICAL
METHOD
HO»BEE
OF CASES
1
BAHGE
a) 30-2.5 UBOl/1
b) 4.5-2.3 UBOl/1
c) 3.3-2.0 UBOl/1
d) 2.0-1.8 UBOl/1
HEAN
a) sot given
b) Not given
c) fiat given
d) Not given
GENERAL ISFORBATIOB
a) Initial measurenent and
Portal vein
b) 15 lin and 4 hr. Peripheral
artery. Initial leasureient 3 u«ol/l
c) 15 Bin and H hr. Peripheral vein
d) 30 «in and » hr.
Initial leasureient
Dose 1040 ag (Q BR)
(1 hr dwell time}.
for 7th treataent at
Estiaated frOB graph
Patients vith adecocarcinOBa of tbe
colon
CIRCINCMS; BLOOD ?L>SHt; D80G
THERJPTJ DRUGS; CHEBOTHER1PY
hr.
Hepatic vein.
1.8 uBol/1
IP in dialysate
Data also given
14 weeks
Speyer, J.L.
Sugarbaker* P.H.
Collins. J.tl.
Dedrick, R.L.
Klecker, R.W., Jr.
flyers. C.E.
19B1
Cancer Research
41:1916-1922
area. (2-broBO-2-ethylbutyr»l)- (8 CI)
EutanaBide, »-(aBinocarbonyl)-2-broBO-2-ethyl- (9 CI)
TJ-65-6
C7-H13-Br-N2-02
«» 237.11, IIP 1 16-1 19 C
TISStll
7395
Blood
EXPOSURE SOOIS
Ingestion
...
iHtLMICll
BETHOD
_
GC
SOT BEE
OP C1SES
4
RANGE
-
a) 30-2 nBOl/Bl
b) 15-5 BBOl/Bl
c) 2-1 niol/il
HEiH
a) Not given
b) Hot given
cj sot given
-
GEKERAL MFOBBATIOX
a) 0.5 and 24 hr after 1 g (4.2 nmol)
b) 2 and 24 hr after 1 g. Initial
BeasureBent 7 n«oL/«l at 0.5 hr.
netabolite (broioethylbnty ra»ide)
c) 0.5 and 24 after 1 g. netabolite
(ethylbntyrlnrea)
Range of Beans
BLOOD; OS DOS: SEDATIVES; BROMINE
ORGANIC COHPOONDS
REFERENCE
Vohland. B.-«.
HadisoeBarto, S.
vanke. B.
1976
Archives of Toxicology
36:31-42
-------
valeric acid, 2-propyl- (8 CI)
pentanoic acid, 2-propyl- f9 CI)
99-66-1
C8-H16-02
g» 144.21, BP 720-121 C at 1« •• Hg, 128-130 C at 20 II Hg
TISSUE
7396
Blood,
E7.POSDBE ROUTE
Ingestion
ABALTTICAL
METHOD
GC
HOBBEB
OF CASES
a)
b)
f)
g)
h) 1
BAHGE
a) Mot applicable
b) Hot applicable
d) Hot applicable
f) 75-2 ug/Bl
g) 35.7-1.2 ug/»l
h) 60-20 ug/»l
HEAH
a) 46.5 ug/al
b) 52.6 ug/»l
d) 56.0 ug/il
f) Hot given
g) Hot given
h) Hot. given
GEHEBAL IBFORBATIOS
a) Bother, at delivery, dose 600 >g
b) Bother, at delivery, dose 800 ig
d) Hotter, at delivery, dose 1200 ig
parturition, cord blood level 69.0
ug/il
f) Infant of b) , 12 hr-8 day after
parturition, cord blood level 80.0
ug/«l
q( Infant of c) , 18 hr-? 1/2 day
after parturition, cord blood level
35.7 ug/ll
h) Infant of d) , 12 hr-2 1/2 day
after parturition, cord blood level
80.8 ug/*l
Daily dose to Bother during pregnancy
with last dose 1.9-12.5 hr before
delivery
e)-h) estiaated fron graph
Epileptic mothers and their full-terB
•ale infants, Tokyo
Jaundice in tuo nevborns
JAPAN; ADULTS; HF.HBOBN; CEHTBAL
SERVOUS srsien DISEASES; BLOOD
PUSBA; AHTICOHVtUSAHTS; DBOG5;
HIPMOTICS; SIDATIVES; PBEGHASCI
BEFEBEHCE
Ishizaki, T.
Tokochi, K.
Tabuchi, T.
1981
Pediatric Pharnacology
1:291-303
(HEXT PAGE)
-------
Valeric acid, 2-propyl- (8 CI)
Pentanoic acid, 2-propyl- (9 CI)
99-66-1
C8-H16-02
B» 144.21, BP 120-121 c at 11 » Hg,
128-130 C at 20
Hg
(COHII8DED)
7397
Blood,
serun
EXPOSURE HOD1E
Ingestlon
AHALITICil
METHOD
GC/BS
1
» on BEE
OF CASES
6
BAHGE
a) Mot given
bj Hot given
c) Hot giv
e) Hot giv
f) Hot giv
g) Hot giv
h) Hot giv
i) Hot giv
5) Hot giv
k) Hot giv
1) Hot giv
•) Hot giv
n) Hot gi.v
o) Hot giv
p) Hot give
g) Not give
(»EXT
flEAH
a) 43.2 ug/il
i>) 70.5 ug/»l
c) 0.6 ug/il
d) 83*3 UCI/B!
e) 62.7 ug/»l
E) 88. 0 ug/il
g) 31.6 ug/ll
h) 41.6 ug/il
i) 43.5 aq/ml
i\ 27.1 ug/«l
k) 80.0 ug/ll
1) 0.5 ug/il
m) 33.3 ug/ll
o) 34.0 ug/Hl
p) 25. 1 ug/»l
g) 31.0 ug/Hl
PAGE)
GEHER1L IHFOEBATIOH
a) naternal level at 4elivecy, 11.7
he after aailr dose of 31 »g/kg.
Hetabolites about 6 ug/il
retabolites about 10 uq/Bl
c) Newborn of a) at 260 hr after
birth. Metabolites 0.7 ug/il
e) Baternal level 1.5 hr after
delivery. 25 aq/kq 6.0 hr before
delivery. Hetabolites about 12 ug/il
f) Cord blood of e) . netabolites
about 12 ug/il
after 7.7 ig/kg. Hetabolites about 3
ug/»l
netabolites about u ug/al
i) Arterial cord blood of g) .
Netabolites about 4 ug/gl
11 naternal level at delivery. 10.7
hr after 26.7 ig/kg, plus 7.4 ig/kg
priaidone. Hetabolites about 4 ng/al
k) Cord blood of j) at delivery.
netabolites about 6 ug/nl
1) Hevborn of j) at 260 hr
•) is in j) , 12 days postnatal
n) naternal level at delivery, 6.0 hr
after 15.5 «g/kg, plus u. 8 ig/kg
priiidone. Netabolites about 3 ug/>l
o) Cord blood of n) . netabolites
about 6 ug/il
p) Hateroal blood at delivery 15.5 hr
after 25.8 igAg plus 5.0 ig/kg
phenytoin. netabolites 3.5 ug/il
q) Cord blood of p) at delivery.
Hetabolites about 5 og/al
c) and 1) estimated froi graph.
Epileptic Bothers and their newborn
6 cf 8 neonates developed icterus
aecnatoruB. ninor abnormalities vere
hernias, diastasis of ausculus rectus
abdoiinis and weak abdominal vails.
2 vere Microcephalic
iDOLTS; FETOS: HEWBORH; CEHIR4L
BEF700S STSTEn DISEASES; B100D SERUH;
BILK; ANIICOKTDLSiBTS; DRUG THERAPI:
DEOGS; I1CTATIOH; HETABOIIIBS;
PBEGNAHCy
DEFERENCE
Sau, H.
Bating, 0.
Koch, S.
Helge, H.
1981
and Ezperinental
Therapeutics
219(31:768-777
N>
00
-------
Valeric acid, 2-propyl- (8 CI)
Peotanoic acid, 2-propyl- (9 CI)
99-66-1
C8-H16-02
H« 144.21, BP 120-121 C at 11 •» Hg, 128-130 C at 20 •• tig
(COHTIHOED)
TISSOE
7398
Bilk
E IPOS ORE FOOTS
Ingestion
ANALYTICAL
BETHOD
GC/BS
_
0
a)
b)
d)
e)
t)
Valeric Tid, 2-propyl-, sodiui salt (8 CI)
Fentanc; acid, 2-propyl-, sodiun salt (9 CI)
1069-66-5
C8-H16-02.Na
BS 167.23
HUH BED
OF CASES
1)
b|
:)
3)
e)
E)
818SB
a) 2.2-5.4 ug/il
b) 0.03H-4.7 ug/il
c) 0.15-1). 72 ug/ll
d) 0.12-1.05 ug/»l
e) 1.2-1.5 ug/.l
f) 0.18-1.6 ug/il
SEA*
a) Hot give
b) Not give
c) Not give
d) Not give
e) Hot give
f) Hot give
SBJEBAL ISFOBHATIOII
a) 4-20 days postnatal (pn) . Dose
31.0 ng/kg/day. Serui levels
83.3-102.2 ug/Bl
b) 5-29 days pn. Dose 10.1 ig/kg/day.
Serui, 4.74-96.3 ug/Bl
c) 3-25 days pa. Dose 9.6 ag/kg/day.
d) 38-47 days pn. Dose 9.5
•g/kg/day. Serua 7.6-26.8 ug/Bl
e) «- 12 days pn. Dose 26.7
Bg/kg/day, plus 7.4 priaidone/kg/day.
serai 33.3-44.6 ug/Bl
f) 7-82 days pn . Dose 25.8 ig/kg/day
plus 5.0 Bg phenytoin/kg/day. Secnn
15.2-73.8 ug/ml
Data also given for aetabolite.
Epileptics
6 cf 8 neonates developed icterus
neonatorUB. Hinor abnornalities were
hernias, diastasis of vusculus rectus
2 were aiccocephalic
ADULTS: FETOS; HEUBOKH; CESTBAL
HEEVOOS STSTEB DISEASES; BLOOD SEBOS;
BILK; ASTICOHVOLSAHTS: DROG THEBAPI;
DBOGS; LACTATIOH; BETABOLITES;
PREGNAHCT
EEFEREBCZ
Hau, H.
Bating, D.
Koch, S.
Rausec, I.
Helge, H.
1981
and Experimental
Therapeutics
219(3) : 768- 777
1
-p-
N3
VO
TISSOE | EXPOSURE B001E
1
I
7399 | Ingestion
Blood, |
plasna |
1
1
1
1
1
ANALYTICAL
BF.THOD
GC
NOBBEB
OF CASES
24
BANGE
27-118 ug/al
5
57.0 +or- 29.6 ug/nl
GEHEBAL IHFOBBATIOH
Bean dose 22.0 igAg/day, plus
phenobarbital
0.25-16.2 yr old epileptics
ACI; CHILDBEB; BLOOD PLASBA;
AKTICOHVOLSAHTS; DBOG IHTEEACTIOH;
DBUG THEBAPY; DBOGS
Suganuaa, T.
Ishizaki, T.
Chiba, K.
Hori, B.
1981
Journal of Pediatrics
99(2) :31»-317
Valeronitrile, S- ((3,4-diiethoxyphenethyl) lethylaiino) -2- (3,4-4i»ethoiyphenyl) -2-isopropyl- (C CI)
Benieneacetonitrile, alpha- (3-( (2- (3,4-ai>ethozrphenyl)ethyl) (ethylaiino) propyl) -3, 4-di«ethoxy-alpha- (1-»etaylethyl) - (9 CI)
52-53-9
C27-H38-H2-04
88 454.59, BP 243-246 C at 0.01 •• Hg
TISSOE | EXPOSOBE ROOTE
1
1
1
7400 I Ingestion
Blood |
1
1
1
1
ANALYTICAL
BETHOD
GC
_ ....
NOBBEB
OF CASES
1
BANGE
Hot applicable
BEAN
8.8 ug/Bl
GEHERAL IHFOBflATICH
Fastmorten saaple, suicidal overdose
40 yr old
AUTOPSIES; SOICIEE; BLOOD: ItlDRETS:
LIV!a; AOTOHOBIC DBOGS; OROG ABOSE;
VASODILATORS; FORENSIC BEDICINE;
BEASUBBBEHT BETBODS; NE» ZZALAHO
BEFEBEHCE
Thonson, B.B.
Pannell. L.K.
1981
Journal of Analytical
Toxicology 5:105-109
(KBIT PAGE)
-------
Valeronitrile, s- ((3.4-diaethoxyphenethyl) methylaaino) -2- (3.4-dimethoxyplienyl) -2-isopropyl- (8 CI)
Benzeneacetonitrile, alpha-<3-((2-(3, 4-diaethoiyphenyl)ethyl) aettylaiino) propyl)-3,4-diaethoxy-alpha- (1-aethylethy1)- ("> CI)
52-53-9
C27-B38-N2-04
HS 854.59, BP 243-246 C at 0.01 IB Hg
(COSTIN8ED)
TISSDE
7K01
Blood,
pi a sn a
7U02
Blood,
plasna
7M03
Blood,
plasma
7«0i»
Blood,
plasBa
EXPOSURE BOOTB
Injection
Ingest ion
Injection
Injection
ANALYTICAL
METHOD
HPLC
HPLC
GC
NUMBER
OP CASES
12
12
II
a) 5
b) 1
c| 1
4) 5
e) 5
f) 5
BASGE
a) 100-500 ng/sl
0) 1-5-20 ng/»l
c) 1.5-9 ng/al
a) 2-90 ng/al
b\ 70-300 ng/al
c) 2-30 ng/al
d) 1.5-50 ng/al
e) 70-150 ng/al
f) 10-60 ng/Ml
a) 80-40 ng/al
b) 7-9 ng/al
c) 600-80 ng/al
d) 30-15 ng/al
a) 50-3 ng/al
b) tO~4 ng/ail
c) 30-7 Jig/ml
d) 40-1 ng/il
«) 40-1 ng/al
f ) 15-1 ng/Ml
(NEXT
HEAH
a) Not given
b) Not given
c) Not given
a) Hot given
b) Hot given
c) Not given
d) Hot given
e) Not given
f) Not given*
a) Not given
b) Not given
c) Not given
d) Not given
a) Not give
c) Not give
d) Not give
e) Not give
£) Not give
PAGE)
GEHE8AI, JSFOBaiTIOK
a) Initial Beasureaents
b) at 300 lin
cj Final aeasurenen ts at 30G-900 Bin
1 5 Kg dose
Estimated froa graph
fibrillation
CUPDIOVASCOLAR DISEASES; BIOOD
PLASHA; ASTIAERHTTHHIC AGENTS; DRUG
THERAPY; DRUGS; BETSBOIITES
a) Initial aeasurenents, <1 hr
b| Peak values, 1-3 hr
c) 12 hr
d) Horverapanil. Initial aeasarenents
at <1 hr
d) »or»erapa«il. Peak values at 1-4
hr
f) Norverapaail. 12 hr
120 ng dose
Estiaated fron graph
Patients with chronic atrial
fibrillation
CARDIOVASC0LAB DISEASES; BLOOD
PUSHA; AHTIARRHITHBIC ASESTS; DPOG
THERAPY; DEOGS; BETAB01ITES
a) 5 and 30 Bin after 10 Bg IV in
left brachial vein. Saaples froa
ascending aorta
b) 5 and 30 Bin after 10 ag IV in
left brachial veio. Saaples frOB
hepatic vein
c) 5 and 30 Bin after 10 ag IA in
brachial artery. Saaples froB
ascending aorta
d) 5 and 20 Bin after 10 ag IA in
brachial artery. Final measurement
17 ng/al at 30 Bin. Saaples froa
hepatic vein
Patients vith organic heart disease.
CARDIOVASCDLA8 DISEASES; BLOOD
PLASKA; ANTIAERHYTBKIC AGENTS; DRUG
THERAPY; HETABOLISK
a) Liver patients, at 1 and 12 hr
hr
c) Intensive care patient, at 1 and 8
hr
4 hr
t] Healthy subjects, upper Halts at
1 and 7 hr
f) Healthy subjects, lover Halts at
1 and 6 hr
After 5 ag
Range of menus (a, d-£)
33-57 yr old liver disease patients.
16-73 yr old intensive cars patients.
29-64 yr old controls
LIVZR DISEASES; BLOOD PLASBA:
AUTIAREnTTHBIC AGENTS; DRUGS
REFEHEKCE
Kates, S.E.
Keefe. D.L.D.
Schwartz, J.
Harapat, s.
Kirsten, E.B.
Harrison, D.c.
1981
Clinical Pharmacology
and Therapeutics
30(1) :4«-51
Kates, R.E.
Keefe, D.L.D.
sohwartz, J.
Harapat, S.
Kirsten, E.B.
Harrison, D.c.
1981
Clinical Pharaacology
and Therapeutics
30(1):44-51
Hoodcock, B.3.
schulz, ».
Kober, a.
Rietbrock, N.
1981
Clinical Pharaacology
and Therapeutics
30(1):52-56
woodcock, B.G.
Vohringer, H. 7.
Rietbrocfc, ».
1981
and Therapeutics
29(1):27-3»
OJ
o
-------
Vale ton! trile, s-((3,4-diaethoxyphenethyl) aethylaaino) -2- (3, 4-diaethoxypheuyl) -2-isopropyl- (8 CI)
Benzeneacetonitrile, alpha- (3- ((2- (3, «-<3i«ethojcyp6eoyl)ethyl) iethylami.no) propyl) -3,4-diaetooxy-alpha- (1-aethylethy1) - (9 CI)
52-53-9
C27-H38-H2-04
BK 454.59, BP 213-246 C at 0.01 aa flg
(CONTINUED)
TISSOE
7(105
Kidney
7H06
liver
EXPOSURE ROOTS
Ingestion
Ingestion
ANALYTICAL
BETHOD
GC
HPLC
GC
HPLC
HOBBER
OF CASES
1
1
BAHGE
17-35 ug/g
132-200 ag
HE1N
Hot applicable
Hot applicable
GESEBAL H»FORSATIO»
.--
Range for different extraction and
aeasurenent aethods. Chlorofora
PostaorteB saaples, suicidal
overdose.
»0 yr old
HOTOPSIES; SOICIDE: BIOOD: KIDBBTS;
IIVEB; AOTOSOHIC DEOGS; DROG 1BOSE;
ViSOOILATOBS; FORENSIC HEDICIKE;
BEASORE11E8T 9ETHODS ; HOT ZEJliHD
Range for different extraction and
•easurenent aethods. chlorofora
extraction gave value of 2.4 ng.
PostnorteM savple, suicidal overdose.
HO yr old
KOTOPSIES; SUICIDE; BLOOD; KIDNEYS;
IKTEP; ABTOSOSIC DRUGS; DROG ABUSE;
VASODILATORS; FOPEHSIC HEDICIBE;
BIASOREnElIT BETHODS; »ES ZEALAND
REFEREHCE
Thomson. B.H.
Pannell. L.K.
Journal of Analytical
Toxicology 5:105-109
Thomson, B.B.
Pannell, L. K.
1981
Journal o£ Analytical
Toxicology 5: 105-109
1
1
Valine, 3-mercapto-, D- (8 CI)
D-valine, 3-«ercapto- (9 CI)
52-67-5
C5-H11-B-02-S
BS 119.21, BP 198.5 C (D-form)
U)
TISSUE
71107
Blood
EXPOSURE ROUTE
Ingestion
IHAITTICAL
BETBOD
HPLC
NOSBEB
OF CASES
1
BAHGE
a) Hot applicable
b) Hot applicable
c) Hot applicable
d) Hot applicable
e) Not applicable
(NEXT
HEAD
a) 6.5 ug/»l
b) 5.9 ug/«l
c) 3.7 ug/ll
d) 2.8 ug/il
e) 1.9 ug/»l
PAGE)
GENERAL IBFORBATIOH
a) Plasna, 120 iin after <750 ag.
solution, fasting subject (50 Kg/Hi
by nasogastric tube, sone lost during
adBinistration)
b) Plasma, 140 Bin after 750 iq ,
capsules, fasting subject
c) Plas«a, 180 ain after 750 «g.
capsules, pceceeded by large
breakfast
d) Whole blood, 120 Bin after 750 mg.
capsules, fasting subject
e) Packed cell concentrations, 140
•in after 750 ag, capsules, fasting
subject
Peaks
Onusual double peaks with first
lower, seen in fasting studies only
Estinated fcon graph
30 yr old, wt 81.6 kg
ALOLTS; BHEOHATOID ABTRRITIS; BLOOD;
BLOOD SEROM; ORIHE; DRUGS;
PENICILLABI«E
REPEBEHCE
Bergstroa, R.F.
Kay, D.R.
Harkcoa, T. n.
Hagner, J.G.
1981
Clinical Pharaacology
and Therapeutics
30(3) :404-413
-------
»aline, 3-iercapto-, D- (8 CI)
D-Valine. 3-iercapto- (9 CI)
52-67-5
CE-B11-H-02-S
BB 109.21, BP 198.5 C (D-fori)
(COHTIHDED)
tISSOE
71108
Blood,
plasia
7W9
nrine
EIPOSOBE POOTE
Injection
Ingestion
aHAHTicil
BETBOD
HPLC
BPLC
HOHBEB
OF CASES
2
5
BAHGE
a) 6.75-8 ug/il
b) 1.SO-6.SO ug/il
c) 3.00-5.00 ng/il
4) 1.75-2.00 ug/ml
a) 245-68.7 ig
b( 178-74. 7 ig
c) 83.7-30.2 ig
d) 32.7-7.5 .g
e) 56.3-10.6 ig
ft lot applicable
8EAH
a) Hot given
b) Hot given
c) Hot given
d( Hot given
a) liot given
b) Hot given
c) Hot given
d) Hot given
e) Hot given
f) 125 «g
GE8ERAL MFORHATIOH
a) 240 and 160 min after 1,000 mq
b) 240 and 150 min after 750 ng
c) 240 and 120 min after 500 *g
d) 240 and 120 min after 250 mg
Range of peaks
Unusual double peaks with first
usually lover
Capsules in Multiples of 125 mg.
oral, after by overnight fast
Normal adults
aCOLTS; BHEOJIiTOID ARTHRITIS; BIOOD;
BLOOD SER0H; OEIHE; DBOGS;
PEBTCT1LAHINE
a) Dose 1000 mgt capsules, Q fasting
subjects
b) Dose 750 »g, capsules* 4 fasting
subjects
c) Dose 500 mq, capsules, 5 fasting
subjects
d) Dose 250 mq, capsules, 5 fasting
subjects
breakfast, 2 subjects
f) Dose <750 ig, solution nasogastric
tube, 1 fasting subject
Normal adults
ftDntTS; BHBanATOID AKTHEITIS; BLOOD;
BLOOD SERDN; DRIME; DBOGS;
EEKICILL4HISE
REPEBEHCE
Becgstroi* B.P.
Kay, D.B.
Hark con, T. S.
Vagn«r, J.G.
1981
Clinical Pharmacology
and Therapeutics
30(3):1
GEIECAL INFOPBVTIOK
aV controls, non-nutrient suppleient
plus lactose-coiLtaining placebo
b) High protein-vitaiin liquid
supplement plus linecal capsule, 6
days/Bit
in b) plus 40 ig Zn as carbonate, 6
days/wit
Bange of leans over 20 lontbs
Ho supplements during 4 10 suner
vacation
Significantly increased bt , vt, and
bone ages in boys receiving Zn during
final 12 10 of supplement at ton.
despite sabnonal Zn levels in plasia
throughout 'study
13 yr old, prepubertal, village
schoolboys, southern Iran
IBM: ADOLESCENTS; HOTBITIOHlL
DEFICIENCIES; BLOOD PLASBA; BIOOD
SEBDH; EBITBBOCITES; C A LCI OH; I BOB;
EHOSPBOBDS; ZI»C J DIETS
KEFEREH CE
Bonaghy, B.A.
SeLnhold, J.6.
Dahloudji, II.
Ghavaii, P-
Spivey Pox, H. B.
1974
Clinical nutrition
27(21:112-121
(HEII PAGE)
-------
Zinc
71100-66-6
ZD
At» 65.38, tit 119.5 C, BP 908 C. VP 1 •» Hg at «87 c, 10 mm Hg at 590 C
(CONTINUED)
TISSUE
Tin
Blood,
plasma
7412
Blood,
plasma
7»13
Blood,
plasma
EXPOSURE ROUTS
Ingestion
Ingestion
Ingestion
ANALTTICAL
HETHOO
its
IAS
NOSBEB
or CASES
a) 11
b) It
c) 6
d) 6
a) 10
b) 20
e> ID
BINGE
a) Not given
b) Hot given
c) not given
d) Hot given
e) Hot given
£) Not given
a) 4.3-11.5 u.ol/1
b) 9.5-17.2 umol/1
c) 9.9-13.9 umol/1
d) 14.3-18.2 umol/1
a) 58-77 ug/100 mi
b) 57-75 ug/100 »1
c) 5»-73 ug/100 ml
BEAN
a) 65.3 ug/100 ml
b) 55.6 ug/100 il
c) 64.3 ug/100 ml
d) 58.5 ug/100 mi
e) 59.0 ug/100 il
f) 48.8 ug/100 il
a) 7.5 *or- 0.6
UBOl/1
b) 13.9 tor- 0.8
UmOl/1
c| 12.1 »or- 0.6
u mo 1/1
d) 16.0 »oc- 0.6
u mo 1/1
a) 68.6 ug/100 mi
o) 66.6 ug/100 ml
c) 64 ug/100 ll
GEHEBAL INFORMATION
a) Pretrea ment, 25 cases
b) Group a after 8 mo regimen of 20
mg Zl\/dav nd 20 mq Ye/day
c) Pretrea meat, 25 cases
d) Group c after 8 mo regimen of 20
mg Pe/day
e) Pretrea cent, placebo, 25 cases
f) Group e after 8 mo
Low zn lev Is thought to be due to
diet high in fiber and phjtates
6-12 yr olds, Iran
zn and Fe supplementation did not
stimulate growth or bone development,
bat ?e alone did.
IP AS; CHILDBEH; BLOOD PLASBA; IHON;
HIT4LS; ZIHC: DIITS; ROB»1 »BE1S
a) Before Zn supplement
b) After Zn supplement
c) Before Zn supplement
d) After Zn supplement
Malnourished children on soya-based
diet (a) and receiving mean of 100
+ or- 16 umol/!tg/day (b) or on cow1 5
milk-based diet (c) and receiving
mean of 7 1 *or- 20 umol/kg/day (d) .
Jamaican 6-17 mo olds, suffering from
marasmus, maramic kwashiorkor or
kwashiorkor.
Zn supplement increased rate of
weight gain, decreased energy ccst of
tissue deposition, and was associated
with regrowth of thymus and
activation of Ha pump.
CHILDREN; HOTRITIOHAl
DEFICIENCIES; B10OD PL ASIA; nETALS;
ZJHC; DIITS; lilHZBAI DWICIBSCIES
a) Controls, non-nutrient supplement
plus lactose-containing placebo
t) ffigh protein-vitamin liquid
supplement plus mineral capsule, 6
days/wk
c) Supplement and mineral capsule as
in b) plus 40 mg Zn as carbonate, 6
aays/wll
Pange of means over 20 months
Ho supplements during 4 mo summer
vacation
significantly increased at, wt, and
bone ages in boys receiving Zn during
final 12 mo of supplementation,
despite subnormal Zn levels in plasma
throughout study
13 yr old, prepubertal, village
schoolboys, southern Iran
IEAS; ADOLSSCEHTS; HOTIIITIOHAJ.
DEFICIENCIES; BLOOD PLASMA; ET.OOD
SEROB; EBTTHBOCTTES; CALCIDH; I BOH;
IBCSPBCRBS; ZIHC: DIETS
(HEX! PAKE)
Bahloudji, B.
Beinhold, J.G.
H&ghshenass, n.
Bonaghy, H.A.
Fox, B.R.S.
Bllsted, J.A.
1975
American Journal of
Clinical Nutrition
28(7):721-725
Solden, H.H.N.
Golden, B.C.
1981
American Journal of
Clinical Nutrition
31:900-908
4>
(^i
U)
Eonaghy, H. A.
Reinhold, J.S.
Bahloodji, fl.
Ghavami, p.
Spivey Fox, H.B.
Halsted, J.A.
1974
American journal of
Clinical nutrition
27(2): 112-121
-------
Zinc
7140-66-6
Zn
US 65.38.
ap 119.5 c, BP 908 c, ff I mm ag at 487 c, 10 >i Hg-at 590 c
(COHTIHOED)
TISSUE
7414
Blood,
plasma
7415
plasma
7116
7417
Blood,
EXPOSURE ROUTE | ANALYTICAL
i
Ingestion
Ingestion
Injection
METHOD
AAS
AAS
AAS
AAS
NOHBEB
OF CASES
a) 6 b) 5
c) d
d) 5
e) 5
f) 5
q) A
h) 5
i) 5
1) 5
7
47
a) 23
b) 22
HAHGE
a) Hot applicable
D) Hot applicable
cj Hot applicable
d) Not applicable
e) Not applicable
g) Sot applicable
h) Not applicable
i) Not applicable
3) Hot applicable
a) Hot applicable
b) Not applicable
c) Not applicable
d) Mot applicable
Rot given
a) 8.5-12.3 umol/1
b) 11.5-16 UBol/X
HEAB
a) »142 ug/dl
b) »43. 5 ug/dl
c) -4 ug/dl
d) »49 ug/dl
e) »42 ug/dl
g) »4 ag/dl
h) *3 ug/dl
i) -6.5 ug/dl
3) -18.5 ug/dl
a) 3.2 ufl/1
b) 12.5 uB/1
c) 21.1 uB/1
d) 12.2 ud/1
99.3 »or- 23.9 ug/dl
a) lot given
b) Hot given
GENERAL IHFOBBATICN
a) 120 g oysters (108 ag Zn)
b) same as a), plus 120 g black bean
gruel (BBG)
c) same as a), plus 120 g corn
tcrtillas (CT)
plus 120 g BBG
e) 120 g oysters, plus 120 g BBG
f) 475 ma znS04.7H20 (108 mg Zn),
plus 120 g CT
g) 120 g oysters (108 mg Zn) , plus
120 g CT
h) 120 g herring
i) Same as h) , plus 70 g white bread
and 10 g batter
1) same as h) , plus 70 g CT
pretest levels (not reported) at 1-1
hr after intake.
Healthy adults
ADULTS; BLOOD PLASMA; COMPARATIVE
EVALUATIONS; HETALS; Z1«C; DIETS;
FCODS
a) During therapy of 1800 mq/day
di-iodohydroxyquinoline (Diodoquin) .
Oral contraceptive taken concurrently
b) 1500 Ag/day Diodoquin, oral
contraceptive discontinued
c) peak, 6 days after start of 150
mq/day ZQS04 supplement, plus 1500
mq/day Diodoquin
d) oral contraceptive taken
concurrently vith 150 mg/day ZnSOl
supplement. Diodoquin discontinued
25 yr old with acrodermatitis
enteropathica
ADULTS; NUTRITIONAL DEFICIENCIES;
NUTRITIONAL DISORDERS; BLOOD SEROH;
URINE; DRUG INTERACTION; DRUG
TBERAPT; OBAL CONTRACEPTIVES; ZINC;
METALS
Mean daily intake, 9.2 tor- 2.5 mg.
no supplements
Seventh-Day Adventist Canadian Homen,
mean age 52.9 +or- 15.3 yr.
vegetarians 19 *or- 17 yr.
ADULTS; BLOOD SEBOT ; HUB;
atmsLOBms; IEOB; zinc; DIETS
a) Postoperative day 2 and 5,
preoperative level 11.4 umol/1
b) Postoperative day 1 and day 5,
pceoperative level 11.7 umol/1. 20
mq Zn and 1.2 mg Cu IV daily
Range of means, estimated from graph.
surgery patients
ADULTS; BLOOD SEROM ; COPPER; RETALS;
ZINC
REFERENCE
Solomons, N.R.
Jacob, G.A.
Pineda, 0.
Viteri, F.
1979
and Clinical Medicine
91(2) :335-313
Jackson, H.J.
19T7
Journal of Clinical
Patholoqy 30:284-287
Anderson, B.N.
G ibson, U.S.
Sate y, J. a.
1981
American Journal of
Clinical Nutrition
34:1042-1048
HaUbook, T.
Bedelin, H.
1978
Acta Chirurgica
Scandimavica
144:423-426
(BEIT PAGE)
-------
Zinc
70IIO-6S-6
Zt
»t» 65,38, HP 119.5 C, BP 908 c, VP 1 •• Hg at 087 c, 10 •• Hg at 590 C
(COHTIHDED)
TISSUE
7»18
Blood,
serum
7419
Hair
7«20
Urine
EXPOSURE BOOTE
Ingestion
Ingestion
Ingestion
AHALITICiL
BETHOD
AAS
HA
its
HUKBEB
OF CASES
33
52
1
BINGE
a) Hot given
b) Hot given
c) Hot given
d) Hot given
e) Hot give
£) Hot give
g) Hot give
a) Hot given
i) Hot give
j) Hot give
Hot given
Hot applicable
HE1H
a) 105 »or- 7 ug/100
•1
b) 212 »or- 17 ug/100
Ml
c) 336 tor- 8 ug/100
.1
i) 227 »or- 8 ug/100
»L
ej 87 *or- 3 ug/100
ml
£) 135 *or- 8 ug/100
•1
g) 131 tor- 7 ug/100
•1
h) 98 *or- »g/100 al
i) 219 tor- 16 ug/100
•1
j) 184 *or- 13 ug/100
•1
187 +or- 44 ug/g
2.9 uM/2(t hr
GB»EBAL I»FOBH1TIO»
a) Fasting, no supple* en t
b) Fasting, 25 ig supplement
c) Fasting, SO ag supplement
d) 50 ng sappleaent with black coffee
only
e) 50 ig supplement with seal plus
•ilk and cheese
f) 50 ag supplement with meaL plus
water and dry neat
g) 50 ng supplement plus meal
h) 50 mg with meal as in a)
i) 50 ng with «eal as in f)
j) 50 mg with mean as in g)
Supplement as sulfate
Basic »eal of coffee, bread, butter
and Jan. Broun bread (high phytic
acid) in e)-g). White bread in h)-j>
Additional data presented for
purified inhibitors.
19-U7 yr olds (mean 28 yr)
Gastric disconfort 1/2-1 hr after 50
tg ia so Be subjects
HQTRITIONAL DEFICIEBCIES; BLOOD
SEBOM; ZINC; DIETS; FOODS
Mean daily intake, 9.2 +or- 2.5 Btg,
no supplements
Seventh-Day Adventist Canadian Women,
vegetarians 19 *or- 11 yr .
ADULTS; BLOOD SEEUH; HAIR;
HEMOGLOBINS; IRON; ZINC; DIETS
Woman talcing oral contraceptives and
1 800 »g/day di-iodohydroxyquinoline
for 2 yr
25 yr old with acroderaatitis
enter opathica
AtOLTS; HaTBITIOHAL DEFICIENCIES;
NUTRITIONAL DISOEDERS; BLOOD SERUH;
URINE; DRUG ISTEEACTION; DRUG
THFRAPY; ORAL CONTRACEPTIVES; ZINC;
HETALS
BBFEBB»C2
Pe,coud, A.
Donzel, p.
Schelling, J. L.
1975
Clinical Pharmacology
and Therapeutics
17 (4): 469-474
Anderson, B.n.
Gibson, 8.S.
Sabry, J. H.
1981
Clinical nutrition
34:1042*1048
Jackson, H. J.
1977
Journal of Clinical
Pathology 30:284-287
U>
Ln
-------
1-penten-4-yn-3-ol, 1-chloro-3-ethyl-
113-18-8
C7-H9-C1-0
nw tin.61, BP 173-17H c, also reported as 181 c
TISSUE
71121
Blood
71122
Blood
71123
Blood
EXPOSURE ROUTE
_
Inhalation
ANALYTICAL
flETHOD
EC
TLC
ov
GC/HS
Enzyiatic
sc
Bit
GC/BS
_ ....
HUHBEE
OF CiSES
1
3
1
BADGE
0-41.5 «g/l
0.30-1.86 »g/100 .1
Not applicable
BEAN
Hot given
.
Mot given
0.63 >g/dl
SEKEFAL INFORSATIOir
Dose probably sufficient to
contribute to signs and syiptois
identical samples foe toxic screen
Overdose drags identified in 50H-70*
of cases
laboratories agreed on 6 of 23 drugs
reported present in serai of 20
patients
levels were variable and appeared
imprecise.
Probable drug overdose patelnts,
Boston, HI
HASSACHUSETTS; BLOOD; ANALGESICS:
ANTICOHVULSANTS; ANTIDEPRESSI VE
AGENTS; ANTIPYRETICS; DRUG ABUSE;
DRUGS; HYPNOTICS: NABCOTICS;
SEDATITES; TBANQUILIZEBS; COKPAEATI'E
EVALUATIONS; ALCOHOLS; HBASUBESENT
BETHODS
Drug induced fatalities. Ethanol (2
cases, 0.09-0.17 g/100 «1) and
secobarbital (1 case, 0.80 >g/100 il)
Auto-psies, 1975-76, Los Angeles
County, CA
CALIFORNIA: AUTOPSIES; CASE
HISTOBIES; BLOOD; DRUG ABUSE; DRUGS;
FOBEHSIC BEDICINE: ALCOHOLS
cocaine and 0.10 ag/dl etbanol also
present
05 yr old, Los Angeles county, CA
CA1IFOBHIA: AOTOPSIES; BILE; BLOOD;
UCINE; DRUG ABUSE; DRUGS; HABCOTICS ;
FOBEHSIC 8EDICINE; INHALATION
Inqelfioger, J.A.
Isakson, G.
Shine, D.
Costello. C.G.
Goldnan, P.
1981
Clinical Pharmacology
and Therapeutics
29(5):570-575
Nakavura, G.B.
Noguchi. T.T.
Griesener, E.c.
1979
Journal of Analytical
Toxicology 3:137-1H2
, G.B.
T.T,
Nakaiura
Noguchi,
1981
Clinical Toxicology
18(8) : 895-905
1-Piperazineethanol, 4- (3- (2- (trif luoroiethyl) -9H-t hLoianthao-9-ylideDe) propyl-. (z) -
53772-82-0
C23-H25-F3-B2-0-S
nil 434.54
TISSUE
7424
liniotic
fluid
EXPOSURE HOOTE
ANALYTICAL
BETHOD
RIA
HOB BEE
OF CASES
2
-
RANGE
0.4-0.5 ng/ll
BE AH
0.45 ng/ll
GENEBtL INFOBIIATION
Dose, 40 >g/2 vk (decanoate). Serui
levels 1.7 and 2.1 ng/il
NEHBOBS; ASNIOIIC FLUID; BLOOD SEBUB;
BI1K; DBDfi THERAPY; DRUGS;
TBANQOTLIZERS; LACTATION; PREGNANCY
REFERENCE
Kirk. L.
Jorgensen, A.
1980
psychopharaacology
72:107-108
(BEIT PAGE)
-------
1-Piperazioeethanol, 4-(3- (2- (ttif Zuoroiethyl) -9H-thioianthen-9-ylideiie) propyl-, (Z| -
53772-82-0
C23-H25-F3-N2-0-S
H» 934.51
(CONTINUED)
TISSUE
7425
Blood,
serun
7426
Bilk
EXPOSURE ROUTE
1-Piperazineethanol, t*-(3-(2-
1-Piperazineethanol, 4-(3-(2-
69-23-8
C22-H26-F3-N3-0-S
«W 137.52, BP 268-274 C at 0.!
TISSUE
71127
Blood,
plasma
EXPOSURE ROOTE
ANALYTICAL
METHOD
RIA
BI»
trif luoronethyl) phe
trif luoro«ethyl)-10
ma Hg, 250-252 C a
ASALYTICAL
METHOD
Radioreceptoc
assay
HOB BEE
OF CiSES
5
3
BINGE
a) 1.3-4.3 ng/«l
b) 0.3-0.9 ng/ml
c) 1.3-1.5 ng/iil
0.8-1.8 ng/ml
MEAN
a) 2.7 nq/Ml
b) 0.6 ng/«l
c) 1.4 Eg/ml
1.6 ng/sl
GENERAL IHFORBATIOH
b) Uabilical cord serui
c) Maternal serun, postpartnn, n-4 1
days
nose 2 ng/day or 30-60 »g/2 or 3 vk
(decanoate)
2»-29 yr olds
DP.DGS; PSYCHOTEOPIC DRUOS;
TRABQDILIZBRS; HEWBORII; BI.OOD SEFUH;
AHNIOTIC FLUID; BIIK; DRUG THEEJPy;
I1CTATION; PBEGSANCY
1.3-1.5 ng/»l. Dose. 2 «g/day or 40
•g/2 wk or 60 mg/3 wk
BEVBORN: AHHTOTIC FLUID; B100D SEROS;
BIIK; DBOG IHERAPI; DRUGS;
TRANQUILIZERS; LACTATION; PREGNANCY
REFERENCE
Kirk, L.
Jorgensen, A.
1980
Psychopharftacolog y
72: 107-108
ICirk. L.
Jorgensen, A.
1980
Psychopharmacology
72:107-108
othiazin-10-yl)propyl) - (8 CI)
i-phenothlazin-10-yllpropyl)- (9 CI)
0.3 ii Hg
NUHBER
OF CftSES
a) 1
b) 1
0) 1
3) 1
BAHGE
a) < 1.0 ng/Ql
b) 2.0-6.5 ng/»l
c) 2.6-U.6 eg/ml
d) 9.1-12.5 og/nl
BEAN
a) Not given
b) Not given
c) Not given
d) Not given
GEBEBAL IIIFOP BSTICK
a) 5 «g/day
b) 15 ng/day
c) 15 rag/ day
d) 30 mg/day
Range of weekly Beans. Treated 3 «k.
Absence of coffee and tea during wk 2
did not increase bioavailatility.
Mentally retarded patients with
psychotic disturbances.
BE« ZEALAND; ADULTS; BEHAVIOR
DISORDERS; SEHTAL RETARDATION; BLOOD
PLASMA; PSYCHOTROPIC DRUGS:
CCnPARATIVE EVALDATIOSS; DI^TS;
TEOGS; CAFFEINE
BEPE8ENCE
Bowen, S.
Taylor, K.n.
Gibb, I. A. del.
1981
Lancet
1 (8231) : 1217-1218
-------
1-Piperiainebutanol, alpha-(4-(1, 1-dimethylethylJ pheny 1) -4- (aydroxydiphenylmethyl) -
cC679-08-8
C32-H41-H-02
US 211.28
SSOE
8
od,
sna
E1CPOSUBE BOOTE
Ingestion
A»ALYTICA1
8ETHOD
BI»
aadiometry
N OH BEE
or CASES
a) 14
b) IK
c) 6
BiHGE
a) 1.303-0.053 ng/«l
b) 4.14H-0.276 ug/»l
c) 342-42 ng-egviT./nl
BEAN
a) Hot given
b) Mot given
c) Not given
GENEBAL INFOEBATION
a) 1 and 48 hr after 60 Bg. Initial
aeasurement 1.255 ng/ml at 0.5 hr.
ADC 1 1.864 ng hr/ml
b) 1 and »8 hr after 180 «g. Initial
measurement 3.344 ng/ml at 0.5 hr.
AUC 44.341 ng hr/ml
c) 1.5 and 12 hr after 60 »g (40 aCi)
of C-14 labelled terfenadine.
Initial measurement 96 ng-equiv,/ml
at 0.5 hr. ADC 2297.71 ng-equiv./Bl
ADtJLTS: BLOOD PLASBA; DBOGS;
ANTIHISTAHISE; BEASDBEBENT BETHODS
BEFEEENCE
Okerholm, B.H.
Seiner, D.L.
Hook, a.H.
aalker, B.J.
Leeson, G.A.
Biedenbach, S. A.
Cawein, B.J.
Dusebout, T.D.
H right, G.J.
Byers, B.
schindler, 7.
Cook, C.E.
1981
Biopharmaceutics (
Drug
Disposition 2:185-190
1
1,2-Propanediol, 3-(2-nitroi»idasol-1-yl)- (SCI)
1,2-Propanediol, 3-<2-nitro-1H-i»ida7ol-1-yl- (9 CI)
12551-92-3
C6-H9-B3-04
fV 187.18
TISSUE
7429
Blood,
plasma
7430
Cerebrosp
inal
fluid
7831
gland
EXPOSOBE ROOIE
Ingestion
Ingestion
..
ANILTTICAt
BETHOD
HPLC
HPLC
HPIC
NOBEEB
OF CASES
a) 16
b| 1
8
1
BASSE
_..
a) 35-2 ug/Bl
b) 28-34 ug/il
0-12 uq/«l
23-33 ug/g
HEAD
a) Not given
b) Not applicable
Hot given
Not applicable
GENERAL INFOBHATION
a) 1 and 24 hr after 1 g/sq •
b) 30 iiin and 3 hr after dose o£ 1
g/sq B. Normalized doses. Final
Estimated from graph.
Patients Mith carcinoma or melanoma
ADULTS; CiBCINOBAS; BELANOBAS; BLOOD
PLASBA; CEBEBBOSPINAL FLOID: BABBART
GLAHDS; DKHG TBEEiPT; BSOGS;
COBPABATIVE EVALUATIONS; CBEBOTBEB API
1 and 3 hr after normalized dose of 1
g/sg m. Final measurement 7 ug/Bl at
13 hr
Estimated from graph.
Patients with malignancies.
ADULTS; CAHCISOBAS; BELANOSiS; BLOOD
PLASBA; CEBEBEOSPINAL FLUID; BASBA8T
GLANDS: DRUG THEEAPI; DEOGS;
COBPABATI7E EV AHJATIOSS; CBEBOTMBiPY
1 and 2 hr after normalized dose of 1
4.5 hr
Estimated from graph. Biopsies of
tumor
Patient Kith breast carciaoma
ADULTS; CaBCINOBAS; BELANOBAS; BLOOD
CllSBA; CEBE8BOSPIN1L FLOID; B1BBABT
GLANDS; DBUS THBEAPY; DBUGS;
COI)P1BJTI7E E7ALO»TIONS; CBEBOTHEfiiPl
BEKBENCE
Dische, S.
Saanders, B.I.
Biley, P.J.
Bennett. B.H.
Stratford, a.B.L.
Binchinton, A.I.
1981
British Journal of
Cancer 43:344-349
Dische, S.
Saunders, H.I.
Riley, P.J.
Rauck, J.
Bennett, B.H.
Stratford, a.B.L.
Binchinton, A.I.
1981
British Journal of
Cancer 43:344-349
Dische, S.
Siley, P.J.
Hauck, J.
Bennett* B.H.
Stratford, B.B.L.
ainchintoi, A.I.
1981
British Journal of
Cancer 43:3*4-349
00
-------
1,4-Dihydroxy-5,8-bis((2-( (2-hydroxyethyl) amino) ethyl) aiino)-9. 10-anthracenedione dihydrochloride (No postings in CHESLINE).
7U32
Elood,
plasna
EXPOSURE ROUTE
Injection
ANALYTICAL
HETBOD
. .
HPLC
HOI! BEE
OP CASES
4
BASSE
400-960 ag/ml
MEAN
630 »or- 223 ug/ml
GENEBAL INFORBATION
Max levels after 30 Bin IT of 12
Bg/sg •
Cancer patients
CARCIHOBAS; SAPCOHAS; BLOOD PLASMA;
DRUG TBEBAPY; DRUGS
REFERENCE
Reynolds, D.L.
Ulrich, K.K.
Pat ton, T.F.
Repta, A.J.
Stecnson, L.A.
Byron. B.C.
Taylor, S.A.
1981
of Pharmaceutics
9:67-71
1alphaH,5alphaH-Tropane-2beta-carboxylic acid, 3beta-hydroxy-, methyl ester, benzoata (ester) (8 CI)
8~Azabicyclo(3.2. II octane-2-carboxylic acid, 3-(benzoyloiy)-8-«ethyl-. methyl ester, (IB-(exo,exo))- (9 CI)
50-36-2
C17-H21-N-04
(IS 303.35, HP 98 C, BP 187-188 C at O.I •• Hq
TISSDE
71133
Bile
7131
Plood
7<135
Elood
7436
Blood
EXEOSORE ROD1E
Injection
Inqestion
Inhalation
Inqestion
Infection
Inhalation
Rectal
I n 1 ec t io n
Inqestion
Inhalation
ANALYTICAL
HETBOD
HI A
GC/BS
GC
CIA
GC/HS
HOKBEB
OF CASES
20
1
a) 3
b) 6
16
RANGE
Trace- 0. 7 U ig/dl
a) Hot applicable
b) Not applicable
a) Hot detected-0.82
ng/100 »1
b) < 0.01-2.1 ng/100 Hi
0.08-0.80 »g/dl
BEAN
Not given
a) 3.6 ug/ul
b) 5.2 ug/«l
a) Not given
b) Not given
Not given
GENERAl IHFOKBATICH
Drag overdose fatalities
18-10 yr olds, Los Angeles County, CA
CALIFORNIA; AOTOPSIES; BILE; BLOOD;
OEINE; DRUG ABOSE; DRUGS; NARCOTICS;
FOB.ENSIC BEDICISE; INHALATION
a) 4 hr after exposure
b) About 24 hr after exposure
After ingestion of 6 Condons
containing 5 g each, 1 of which
ruptured during endoscopy.
31 yr old
Disorientation, euphoria, loss of
consciousness. Systolic pressure 40
BB Hg, pulse rate 140/Bin. Apnea,
seiz ures
BLOOD; DRUG ABUSE; DRUGS; NARCOTICS
a) Cocaine overdose implicated as
b) Other drugs present
overdose or suicide victims, CA and
TX
SUICIDE; BLOOD; ERSIN; ETE; KIDHETS;
LIVEP; I.ON3S; DBINE; OEDG ABDSE;
DRUGS; NARCOTICS; CALIFORNIA; TEXAS
Deaths attributed to cocaine
overdose. In 6 other drug fatalities
0.13 mg/dl and other drugs, including
BOrphine, codeine, methaqualone, were
also found.
18-40 yr olds, Los Angeles County, CA
CJLIFCBNIA; AUTOPSIES; BILI; BLOOD;
OPINE; DStJG ABUSE; DRDGS; NARCOTICS;
FCBENSIC BEDICINE; INHALATION
_ -
REFEBENCE
Nakamura, G.R.
Noguchi, T.T.
1981
Clinical Toxicology
18(8) : 895-905
Suarez, C.A.
Arango, A.
Lester, J.L.
1977
Journal of the Aaerican
Bedical Association
238(13) :139 1-1392
Lundberg, G.D.
Garriott, J.c.
Reynolds, P.C.
Cravey, R.H.
Shair, R.F.
1977
Sciences 22(21:402-408
Nakamura, G.B.
Noquchi, T.T.
1981
Clinical Toxicology
18(8) : 895-905
(NEXT PAGE)
-P-
w
VO
-------
1alphaB,5alphaH-Tropane-2beta-carboxylic acid. 3beta-hydroiy-, methyl ester, benzoate (ester) (8 CI)
8-Habicyclo(3.2.11octane-2-carboxvlic acid, 3- (benzoyloiy)-S-iiethyl-. methyl ester, (IS- (exo.exo)) - (9 CI)
50-36-2
C17-B21-N-04
PS 303.35, HP 98 C, Bp 187-188 C at O.I mm Hg
(COHTISOED)
TISSUE
7H37
Brain
7438
7H39
Liver
7(HiO
lung
7IU1
Or ice
orine
7HH3
Orine
EXPOSU8E P00TB
In-jection
Inhalation
In lection
Injection
Inhalation
Injection
Inhalation
Injection
Inhalation
Rectal
_ _.
Injection
..
ANALYTICAL
METHOD
CC
CC
CC
CC
._
CC
-
TIC
RIA
Enzyme
Immunoassay
BIA
GC/BS
NOKBER
OF CASES
a| 1
b) 2
a) 2
a» 3
b) 6
a) 1
b) 3
4
1
-
BANGE
a) Not applicable
b) 0.03-1.5 mg/100 g
a) 1.68-2.70 mg/100 g
a) 0.01-0. 15 19/100 g
b) Hot detected- 2.0
mg/100 g
a) Hot applicable
b) 0.09-0.6 mg/100 g
0.15-21.5 mg/100 ml
b) 10.50-39.11 mq
c) 13.62-41.07 mg
Hot applicable
(KBIT
MEAN
a) 0. OK mg/100 g
b) not given
a) Not given
Not given
b) Not given
a) 0.01 mg/100 g
b) Not given
Not given
b) Not given
c) Not given
0.18 mg/dl
PASS)
GEKEEHL INFOGBATICN
a) cocaine overdose itplicated as
direct cause of death
b) other drugs present
Overdose or suicide victins, CA
SDICIDE; BLOOD; BHilH; EIE J ICIDSETS;
IIVES; in»SS; DBINE; DBOS ABOSE;
DBOGS; NARCOTICS; CAIIFOBNH; TEltAS
a) cocaine overdose implicated as
b) Other drugs present
Overdose or suicide victims, CA
SDICIDE; BLOOD; BBAIN; EIE; SIDNEYS;
IIVBP; lanes; UBIHE; DEDG IBOSE;
DBOGS; NARCOTICS; CALIFORNIA; TEXAS
a) cocaine overdose implicated as
direct cause of death
b) other drugs present
Overdose or suicide victims, Ci
SUICIDE; BLOOD; BBAIN; EYE; KIDNEYS;
LITER; LOSSS; URISE; DRDO ABUSE:
CPDGS; NARCOTICS; CALIFORNIA; TET.AS
a) cocaine overdose implicated as
direct cause of death
b) Other drugs present
Overdose or suicide victims, CA
LITER; LUNGS; (JRIHE; DSKG ABBSE;
DEOGS; NABCOTICS; CALIFORNIA; TEXAS
Drug overdose, or suicide victims, CA
and TX. other drugs also present
SDICIDE; BLOOD; BRAIN; EYE; KIDNEYS;
LIVER; LUNGS; DBINE; DRDG ABUSE;
DRUGS; HABCOTICS; CALIIOSNH; TEXAS
b) Hetabolite (benzoylecgonine) , 24
hr
c) Total, 168 hr
Dose 66.96-109.73 mq (average 98. 2T
absorbed)
Healthy 23-34 yr olds
OEINE; DBDGS; NARCOTICS; HEiSOBEHENT
BETHODS
Cose unknown* autopsy data
37 rr old resident of Los Angeles
County, CA
CALIFOEHIi; WTOPSIES; BILE; BLOOD;
HEINE; DBDG ABDSE; DROSS; NABCOTICS;
FORENSIC MEDICINE; INHALATION
BEFEBENCE
Lundberg, G.D.
Garriott, J.C.
Bevnolds, P.C.
Cravey, E.H.
Shaw, R.F.
1977
Journal of Forensic
Sciences 22 (2) :402-408
Lundberg, G.D.
Reynolds, p.c.
Cravey, B.H.
Shaw, E.F.
1977
Journal of Forensic
Sciences 22(21:402-408
Lundberg, G.D.
Garriott, J.C.
Reynolds, P.c.
Cravey, B.H.
Shaw, B.F.
1977
Journal of Forensic
Sciences 22(2) :4 02-408
Lundberg, 5,0,
Garriott, J.C.
Reynolds, P.c.
Cravey, B.H.
Shaw, R.F.
1977
Sciences 22 (2) : 402-408
Lundberg, G.D.
Garriott, J.C.
Reynolds, P.c.
Cravey, B.H.
Shaw, R.F.
1977
Journal of Forensic
Sciences 22|2) :402-408
Wallace, J.E.
Shimek, E.L.
Land, p.
Harris, S.C.
christenson, J.G.
1977
Journal of Forensic
Sciences 22 («) .-697-707
Nakamura, S.R.
Nognchi, T.T.
1981
clinical Toxicology
18 (8): 895-9 05
-------
1alphaH,5alphaH-Tropane-2beta-carboxylic acia, 3beta-hydroxy-, lethyl ester, benzoate (ester) (8 CI)
9-Hzabicyclo (3.2. 1)octane-2-carboxylic acid. 3- (benzoyloxy) -8-«ethyl-, «ethyl ester, (IB- (exo.exo)) - (9CI1
50-36-2
ci7-B2i-N-o«
«» 303.35, HP 98 C, BP 187-188 C at 0.1 » Hq
(COSTIBOED)
TISSUE
Till
Vitceous
hunor
EXPOSURE K001E
._. _
Injection
.
IHILYTICH
BETHOD
CC
K08B1B
OF cases
1
BINGE
Not applicable
HE4N
0.38 ig/100 ml
GESEBAL IN FOB SATIOH
Overdose victia, TX
SOICIOE; BLOOD: BEJIH; ETE ; KIDNETS;
tITEB; LOSGS; nEIBE; DBOS IBHSZ;
DBOGS; H1ECOTICS; C4LIF08SIA; TEX4S
BEFEHENCE
LUDdberq, G.D.
Garriott, J.c.
Peynolds, P.C.
Cravey, D.H.
Shav, B.F.
1977
Joaciidl of Foce&sic
Sciences 22 (2) :«02-»08
2-(2-«ethoxy-«-(«ethylsul£iiiyl) phenjl)-
73384-60-8
C14-H13-N3-02-S
H« 287.36
TISSUE
Blooa,
plasma
74U6
arine
EXPOSUBE BOIITE
Ingestion
Ingest ion
AHJLYTICAL
HETHOD
N OB BEE
OP CASES
EANGE
b) 1575-<10 ng/ml
c) 940-<10 ng/al
e) <140-<10 ng/al
_
Not given
HEAH
b) Not given
c) Kot given
e) Not given
51X
GENEEAL IKFOEIIATIOll
0.7 mg/kg IV
b) 30 ain and 10 hr after 150 »g.
ng/al at 15 ain
c) 15 Bin and 8 hr after 100 ag , oral
d) 15 min and 8 hr after 75 mg, oral
e) 15 Bin and 8 hr after 50 ag, oral
Healthy 30-59 yr olds.
BLOOD PLISIU; H8TIABBHITHBIC &GEKTS ;
DEDGS
J radioactivity of 2.0 ag/kg dose
eliainated in 24 hr
OFIHE; AHTIAEBHYTHHIC AGENTS; DBOGSj
BITABOLITES
BEFEEENCE
Ziaaer, A.
Busch, n.
Arzneiaittel-Forschting/
Drug Besearch
31 (1) , 1a:236-239
Eoth W.
Proi, A.
Beuter, A.
Schaxd, J.
Ziiaer, A.
2ipp, H.
1981
Arzneiaittel-Forschung/
Drug Besearch
31 (1), US232-231;
-------
IH-Indene-3-aeetic acid, 5-Elaoro-2-«ethyl-1-( (»-»ethylsalf injl) pbtenyl) methylene) -,
38194-50-2
C2o-nn-r-o3-s
(1» 356. It, np 182-185 c (dec)
(Z)-
I TISSOE
7UU7
Blood,
plasna
7»«8
tjrine
EXPOSURE 80DTE
Ingestioc
Ingestion
ANkLYTICtL
BETHOD
HP1C
HPLC
NUBBEE
OP C1SES
»
a
B1HGE
a) 5.0-0.3 Uq/«l
b| 0.2-2.5 ug/Bl
c) 0.11-1.6 ug/ol
a) Sot given
b) Not given
BEJB
a) Sot given
i) Hot given
c) Hot given
a) 15.6 *q
b) 27.17 »g
GENERAL INFORMATION
a) Sulindac. 2 and 8 hr after dose.
Initial Measurement 0.35 ug/sl at
about 15 »in
b) Metabolite (sulindac sulfide),
0.5 and 3.5 he after dose. Final
•easureoent 0.5 ug/nl at 8 hr
c) Metabolite (salindac sulfone).
0.5 and 3 hr after dose. Final
•easurenent 0.8 ug/al at 8 hr
Dose 200 iag
Kange of neans, estinated fro« graph.
Healthy 30-
-------
1IR-Pyrido(2,1-b)guinazoline-8-carboxylic acid, 2-methory-11-oxo
63091-36-0
CU-H10-B2-OH
MS 210.26
TISSUE
7450
Blood.
plasma
EXPOSURE BOUTE
Ingestion
ANALYTICAL
BETBOD
RIA
HOJ
OF C
a) 1
b) 1
c) 1
nun BUB
OF CASES
>) 1
b) 1
:) 1
HUGE
a) 280-2 ng/ml
b) 700-3 ng/ul
c) 6000*3 ng/ml
.
BEAN
a) Not applicable
b) Hot applicable
c) Hot applicable
GENEBAL IBFOPBATIOB
a) About 2 and 36 hr after 2 mg.
Initial measurement 220 ng/ml
b) About 3 and 36 hr after 10 ig.
c) About 0.5 and 60 hr after 50 mg
Estimated from graph
Healthy adults
B100D PLAS1A; AUTON09IC DRUGS; DBUGS;
ANTIHISTABINE; BBiSOBEBENT BETHODS
DEFERENCE
Dixon, B.
Lucek, B.
Ha, T.-T.
Parsonnet, B.
1980
Research Communications
in Chemical Pathology
and Pharmacology
30(1) : 163-170
2-Butanol, 1-(dinet hylamino)-3-»ethyl-1,2-diphenyl-, propionate (ester), (2S,3B)- (8 CI)
Benieneethanol, alpha-(2-(di»ethyla«ino)-l-methylethyl)-alpl>a-phenyl-. propanoate (ester), (S-(B«,S*))- (9CI)
069-62-5
C22-B29-N-02
n« 339.«8, BP 75-76 C
TISSUE
7H51
Blood
7»52
_
7U53
Plood
SXrOSBBE BOB-IE
ABALITICAL
BETHOD
6C
TIC
0V
GC/BS
Enzyaatic
GC
DV
N UHOEB
OF CASES
2
1859
10
BANGE
0-0.2 «g/l
0->20 ug/iil
0.02-0.50 mg/100 ml
(NEXT
BEAN
Hot given
Not given
Not given
PAGE)
GENERAL INFOBHATION
Doses probably less than toxic amount
Besults from H laboratories receiving
identical samples for toxic screen
Overdose drugs identified in 50K-70*
of cases
laboratories agreed on 6 of 23. drugs
reported present in serun cf 20
patients
levels vere variable and appeared
imprecise.
Probable drug overdose patients.
Boston, HA
HAS5ACHOSETTS; BLOOD; AHALBESICS;
ANTICONVDLSANTS; ANTIDEPBESSI VE
AGENTS; ANTIPYRETICS; DRUG ABUSE;
DROGS; HYPNOTICS; NARCOTICS;
SEDATIVES; TFANatHLIZEBS; COMPARATIVE
EVALUATIONS; ALCOHOLS; BEA SOREBENT
BETHODS
_
88.6* were multiple drug toxicities.
therapeutic ranges
Autopsy reports. United States and
Canada, 1976-78
ADULTS; AUTOPSIES: BLOOD; ANALGESICS;
DEUG ABUSE; DEUGS; FORENSIC BFDICINE
Drug induced fatalities. Bthanol (7
cases, 0. 03-0.3U g/100 ml) ,
phenobarbital (3 cases, 0.1-0.7
•g/100 ml) , and pentobarbital (2
cases, 0.3-0.7 mg/100 ml).
diphenhydram (1 case, 0.2 mg/MQO ml) ,
tethagualone (1 case, 0.30 mg/100 ml)
also found.
Autopsies, 1975-76, Los Angeles
County, CA
CALIFORNIA: AUTOPSIES! CASE
HISTORIES; BLOOD; BBUG ABUSE; DBDGS ;
FORENSIC BEDICINE; ALCOHOLS
REFEBENCE
Ingelfinger, J.A.
Isakson, G.
Shine, D.
Costello, C.E.
Goldman, P.
1981
Clinical Pharmacology
and Therapeutics
29(5) :570-575
Finkle, B.S.
Garriott, J.c.
lonforte, J.8.
Shaw, R.F.
Sonsalla, P.K.
1981
Sciences 26 (U) :739-757
Nakaiuca, G.R.
Noguchi, T. T.
Griesemer, B.C.
1979
Journal of Analytical
Toxicology 3: 137-142
-------
l|-(di«ethyla»ino)-3-«ethyl-1,2-diphenyl-, propionate (ester), (2S.3
ianol, alpha- (2- (diaethyla lino) -l-Bethylethyl)-alpha-phenyl-, propaao
2-Butanol,
Benzeneeth
169-62-5
C22-H29-N-02
BH 339.»8, HP 75-76 C
(2S.3R)- (8 CI)
ate (ester),
(CONTINUED)
TISSUE
7»5(
Blood
7U55
Elool
7H56
Liver
EXPOSURE EOOTE
Ingestion
Ingestion
ANALYTICAL
BETHOD
TIC
GC
GC
TLC
GC
N OH BEE
OF CASES
1
2
1
RANGE
a) Hot applicable
b) Not applicable
Not applicable
a) Not applicable
b) Not applicable
-
ItEAH
a) 0. 10 ag/kg
b) 1. 70 »g/kg
0.07 agX
a) 5.6 ig/kg
b) 16.0 ag/kg
GENERAL ISFORSATIOH
a) Propoxyphene
b) Norpropoxyphene
100 ng Oarvon-H ttx/day as drug
20511 g stillborn infant of 21 yr old
heroin-dependent Bother on
detoxification prograa for 1 yr
acute intoxication. Bother had
ingested or injected BOrphine
derivative and/or propoxypbene.
FETUS: INFANTS; BLOOD; BRAIN;
KIDH5Y.S; LIVES; LUHGS; ANALGESICS:
DRUG ABUSE; DRUGS; NARCOTICS;
BETABOLISH; BETABOLITES
Drivers fatally injured in single- car
crash. Blood alcohol 220 ag*
North Carolina
SOETH CAROLINA; BLOOD; DRUG ABUSE;
DRUGS; ALCOHOLS
a) Propoxyphene
b) Norpropoxyphene
100 Bg Darvon-N HX/day as drug
substitute
heroin-dependent Bother on
detoxification prograa for 1 yr
acute intoxication. Bother had
ingested or injected aorphine
derivative and/or Propoxyphene.
FETUS; INFANTS; BLOOD; BRAIN;
KIDNEIS; LIVER: LUHGS; ANALGESICS;
DRUG ABUSE; DRUGS; NARCOTICS;
HETABOLISS; SETABOLITES
REFERENCE
Cravey, R.H.
Reed, D.
1981
18(8) :9 11-9 111
Turk, R.F.
BcBay, A.J.
Hudson, P.
1971
Journal of Forensic
sciences 19 (1| :90-97
Cravey, R.H.
Reed, D.
1981
Clinical Toxicology
18 (8): 9 11-9 14
-------
2-Imidazoline, 2- (2,6-dichloroanilino) - <8 CI)
Benzenamine, 2,6-dichloro-N-2-iiidazolidinylldene- (9 CI)
6205-90-7
C9-H9-C12-N3
ni 230.11, 8P 305 C
TISSUE
7457
Blood ,
plasma
EXPOSURE ROUTE
Ingestion
ANALYTICAL
BETHOD
6C
NOBBEB
OF CASES
a) 2
b) 3
c) 5
d) 14
BINGE
a) 3.9-2.3 ng/ml
b) 1.2-2.2 ng/ml
c) 0.6-1.1 ng/ml
d) 0.4-0.7 ng/«l
BEAN
a) Hot given
b) Hot given
c) Not given
d) Not given
GENERAL INFORBATION
a) 600 ug 2z/day. 2 and 12 hr after
morning dose. 3.1 ng/ml at 0 he
b) 400 ag 2z/day. 0 and 2 hr after
sorning dose. 1.6 ng/ml at 12 hr
c) 200 ug 2j/day. 0 and 2 hr after
acrning dose. 0.7 ng/ml at 12 hr
d) 100 ag 2x/day. 0 and 2 hr after
norning dose. 0.5 ng/ml at 12 hr
Correlation with systolic blood
pressure
Range of Means
1(2-61 yr old hypertension patients
BIOOD PLASBA; ANTIHYPEBTEN SIVE
AGENTS; DRUGS; BIOOD PBESSUBE
BEFBBE8CE
Hogan, H.J.
vallin, J.D.
Chu, I.-C.
1981
Clinical Pharmacology
and Therapeutics
30(6) : 729-7311
2-Propanol
2-Propanol
525-66-6
C16-H21-N-02
HE 259.34, HP 96 C
- (isopropylamino) -3-( 1-naphthyloxy) - (8 CI)
-({1-methYlethyl)aBino)-3-(1-naphthalenyloxy)- (9 CI)
7H58
Blood,
plasma
7(159
Blood,
plasma
EXPOSOKE ROOTE
Inqestion
Inqestion
ANALYTICAL
HETHOD
Fluorometcy
NUBBER
OF CASES
a) 8
b) S
22
B>NGE
a) 91-12 ng/al
b) 57-11 ng/ml
a) 5-205 ng/«l
b) 35-251 ng/ml
c) Not given
d) Not given
e) Not given
f) Not given
HEAN
a) Not given
b) Not given
a) 38.6 *or- 5.6
ng/ml
b) 74.5 »or- 11.5
ng/ml
c) 33.6 *or- 7.8
tig/ml
d) 61.9 »or- 15.9
ng/ml
e) 58. 1 *or- 6. 4
ng/ml
f) 87.4 +or— 19.6
ng/ml
GENEEAL INFORMATION
a) At 1 and 10 hr after 80 »g dose
b) At 1 and 10 hr after 80 mg dcse
mg/100 ml (»ean 67.8 »or- 55.2 mg/100
ml)
Range of means
Healthy students, mean age 22.9 yr.
mean wt 63.9 kg.
ADULTS; BLOOD PLASBA; ANTI A8RHYTHBIC
•GENTS; DRUG INTERACTION; DRUGS;
AICOHOLE
a) 22 hyperthyroid patients.
continuous treatment for 8.4 *or- 0.5
days
b) 18 euthyroid patients from a)
following surgery (12), carbinazol
(3), or radioiodine therapy (3).
Continuous treatment for 5.6 tor- 0.6
wk
c) Smokers in a), mean age 45 +or- 5
yr, 11 patients
+or- 5 yr, 11 patients
e) Smokers in b) , 8 patients
f) Non-smokers in b) , 11 patients
4 hr after 160 mg/day
Positive correlation of plasma levels
with age in both hyperthyrcid and
euthyroid patients
Levels higher in smokers.
16-75 yr olds, mean wt 53.9 +or- 1.9
kg (hyperthyroids) and 56.1 +or- 1.8
kg (euthyroids)
HTPBRTHYROIDISB; »GE; BLOOD PLASBA;
ANTIARRBTTHBIC AGENTS; D^UG THEBAPY;
DEUGS; SMOKING
REFERENCE
Sotaiuemi, E. A.
Anttila, B.
Rautio, A.
Stengard, J.
Saukko, P.
Jarvensivu, P.
1981
Clinical Pharmacology
and Therapeutics
29(6) :705-710
Feely, J.
Crooks, J.
Stevenson, I. H .
1981
British Journal of
Clinical Pharmacology
12:73-78
(NEXT PAGE)
-------
2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)- (8 CI)
2-Propanol, 1- ((1-methylethyl) a lino) -3-( 1-naphthalenyloxy) - (9 ci)
525-66-6
C16-H21-H-02
BB 259.34, HP 96 C
7460
Elood,
serun
7461
Blood,
whole
EIPOSOBE FOOTE
Ingestion
Ingestion
ANALYTICAL
BETHOD
Fluorometry
Fluorometry
(COHTIHOED)
SUHBSB
OF C»SE3
7
-
6
BANGS
a) 0-144 ng/ml
b) 0-382 ng/ml
c| 21-102 ng/ml
d) 81-287 09/1!
e) 206-562 ng/ml
a) 172.5-15 ug/1
b) 85-10 ug/1
MEAN
a) 36 ng/ml
b) 80 ng/Dl
c) 100 ng/ml
d) 149 ng/ml
e) 373 ng/Bl
a) Not given
b) Not given
GENERAL ISFORBATICN
a) 10 jig
b) 20 mg
c| 40 »g
d) 80 mg
€) 160 mg
Dose 4 x daily
tachycardia correlated with level
Ho reliable way to document beta
blockade when exercise could not be
perforned
Healthy 22-28 yr olds
AOTLTS; HE1BT DISEASES; BLOOD SEBUH;
ANTIAEBHYTHHIC AGEHTS; DBOG TBEBAPY;
DRUGS
a) 1.5 and 12 he after 60 lg dose.
Initial measurement 30 ug/1 at 30
•in. Area under the curve (ADC) 727
+or- 125.6 ug/1 Bin
b) 1.4 and 12 hr after 80 mg dose.
Initial measurement 12 ag/1 at 30
«in. IOC 450 *or- 167.9 ug/1 min.
Cimetidine users (Ig/day)
Estimated from graph
22-70 yr old patients with peptic
ulcers
BLOOD: DRUG IHTEBiCTION; DSOGS
BEFEBESCE
Hager, U.D.
Pieniaszek, B.J. , Jr.
Perrier, D.
Wayersohn, H.
Goldberger, V.
1981
and Therapeutics
30(31:283-290
Heagerty, A.H.
Donovan. R.A.
Castleden, C.I.
Pohl, J.F.
Patel, L.
Bedgesf A.
1981
British Bedical Journal
282: 1917-1919
2-Propanol, - (tert-butylamino) -3- ( (4-morcholi.no-1,2r5-thiadia2Ol-3-yl) oxy) -, (S)-(-)- (8 CI)
2-Propanol. -( (1.1-dimethylethyl) amino)-3-( (4-(4-morpholinyl)-1.2, 5-thiadiazol-3-yl) oxyl-, (S) - (9 CII
26839-75-8
C13-H24-N4-03-S
BV 316.42, (IP 71.5-72.5 C
TISSUE
7462
Blood,
plasma
EXPOSORE BOBTE
Ingestion
ANALYTICAL
BETHOD
OC-EC
NUBBEF
or CASES
—— ^ ^ —
14
EAHGE
a) H.5-92.25 ng/ml
b) 21.0-105.6 ng/ml
c) 43.7-231.0 ug/ml
d) 30.2-160.75 ng/ml
e) 11.5-194.0 ug/ml
HEAN
a) 36.0 *or- 9.3
ng/ml
b) 53.7 »or- 13.39
ng/ml
c) 111.2 tor- 11.7
ng/ml
d) 69.3 tor- 19.95
ng/ml
e) 93.2 tor— 19*56
ng/ml
SE«
GE8EBAL IH FOR NATION
a) 5 mg, 3 x/d. 8 controls
b) 10 mg, 3 x/d. 8 controls
c) 15 mg, 3 x/d. 8 controls
d) 15 mg, 3 x/d. 6 coronary artery
patients
e) 25 mg and 20 mg doses, 2 x/d. 6
coronary artery patients
Peak levels, about 1.5 hr after dose.
Considerable beta-blocking effects.
Systolic time intervals of coronary
patients affected. Equipotent doses
prolonged the preejection period.
isovolumetric contraction time, and
ratio of pteejection period over left
ventricular election time.
CAFDIOVJSCOLAR DISEASES; HEABT
DISEASES; BLOOD PL1SBA;
ANTIBIPEBTENSIVE AGEHTS; DROG
THEBAPI; DRUGS
REFERENCE
Singh, B.N.
ffilliams, F.n.
Khitlock, R.B. L.
Collett, J.
Chew, C.
1980
Clinical pharmacology
and Therapeutics
2 8 (2 ) : 1 59— 1 66
-------
2-Propanol, 1- (1- (2-methoxyethyl) phenoxy) -3- ((1 -nethylethyl) amxno)-, (+-) -
37350-58-6
C15-H25-H-03
flW 267.38
TISSUE
7(163
Blood,
plasia
EXPOSOfiF RODTE
Ingestion
AHALTTICU.
BETHOD
CC
SOSBEB
OF CASES
a) 5
b) 5
c) 5
d) 5
BADGE
a) 50-4 ng/Bl
b) 90-1 ng/ml
c) 200-8 ng/ml
d) 500-7 ng/ml
BEAU
a) Not given
b) -*;ot given
c) Not given
d) Sot given
GENERAL INFOHBATIOH
a) 2 and 33 hr after 50 >g. Initial
measurement HO ng/ml at 1 hr
b) 2 and 33 hr after 100 «g. Initial
measurement 80 ng/Bl at 1 hr
c) 2 and 2« hr after 200 mg. Initial
•easureaent 180 ng/Bl at 1 hr
4) 1 and 33 hr after 100 «q
Healthy 18-33 yr olds
Duration of cardiac beta blocking
activity determined by elimination
half life and dose.
»DOLTS: BLOOD PLASHA; DRUGS;
CCBPABATIVE EVALUATIONS
BEFEBEIICE
Harron, D.H.G
Balnave, K.
Kinney, C.D.
Bilson, H.
Russell, C.J.
Shanks. E.G.
1981
and Therapeutics
29(3) : 2 95-302
2-Propen-1-amine, 3- (U-bromophenyl) -N,S-dimethyl-3- (3-pyridinyl)-, (Z)-
56775-68-3
C16-H17-Br-S2
ns 317.25
TISSOE
7U6U
Elood,
7U65
Cerebrosp
inal
fluid
\
I
1
EXPOSOEE POOIE
Ingestion
ANALYTICAL
BETHOD
CC
CC
SOBBED
OF CASES
8
8
BAHGE
.
a) 29. 2- 102. « ng/»l
b) 145.14-554 ng/Bl
a) 2.7-6.9 ng/ml
b) 26.7-72.0 ng/ml
MEAN
a) 71.3 *or- 29.4
iig/ml
b) 251. 1 tor- 142-t
ng/ml
a) 5.7 +or- 1.8 ng/ml
b) 42.9 *or- 16.1
ng/ml
GENERAL IKFOBH1TIOH
a) zioelidine
b) Norzimelidine (active metabolite)
8.
-------
2,»-Piperiainedione, 3,3-diethyl-5-Bethyl-
125-611-li
cio-an-N-o2
»» 183.26, HP 74-77 C
TISSUE
7(66
Bloo3
FXPOSUBE ROUTE
ANALYTICAL
HETHOD
BOB BEE
OF CASES
3
SSSGB
0.87-3.57 Bg/100 »1
.
BEAN
Not given
GESEBAL IHFOHBATIOB
Drag induced fatalities. Ethanol (2
cases, 0.01-0.20 g/100 «1) ana
apobarbital-secobarbital (1 case.
0.80 ag/100 Bl) also found.
Autopsies, 1975-76, Los Angeles
County, CA
CALIFORNIA; AUTOPSIES; CASE
HISTORIES; BLOOD; DRUG ABUSE; DRUGS ;
FORENSIC HEDICISE; ALCOHOLS
BEFEREHCE
Nakaaura, G.K.
Noguchi, T.T.
Grieseaec, B.C.
1979
Journal of Analytical
Toxicology 3:137-142
2.1-Pyriiidinediamine, 6-(1-piperidinyl)-, 3-oxide
3830l|-9l-5
C9-B15-B5-0
B» 209.29
TISSUE
71167
Elood,
serum
EIPOSDBE ROUTE
ANALYTICAL
METHOD
HOflBES
OF CASES
1
B4NGE
150-0.5 ng/Bl
HE4S
Hat applicable
GEHEBAL IHFOB BATICB
3 hr and 13 hr after ingestion of
possibly as BUCh as 100 ng
2 yr old boy
Beflex tachycardia was observed
pulse rate dropped fron 160/nin to
120/«in
CHILDBEH; BLOOD SEBU»;
ABTIHYPEBTEHSIVE AGENTS
_
REFERENCE
Isles, C.
flacKay, A.
Barton, P.J.B.
Bitchell. I.
1981
Lancet 1(8211) :97
2,»r6(1H,3H,5S)-PyriDiidinetri
8065-05-2
C 12-H18-H2-03.C11-al8-»2-03.2
n« 510.61
oe, 5-ethyl-5-(3-Bethylbutyl)-, BOnosodiuK salt, Bijtt. Kith 5- (1-aethylbutyl) -5- (2-propenyl) -2,1,6 (1H.3H, 5H) -pyriBidinetrione BOnosodiUB salt
TISSUE
7168
Biooa
EXPOSOBE BOOTE
ANALYTICAL
BETHOD
UT
NUBBEB
OF CASES
,
BANGE
0.3-0. 8 Bg/100 Bl
BEAN
Not given
Or
ca
ph
•1
Au
Co
CJ
Bl
FO
GENERAL INFOBBATION
Drug induced fatalities. Ethanol (3
cases, 0.02-0.19 g/100 Bl) ,
phenobarbital (1 case, 0.5 Bg/100
and phenytoin (1 case, 0.16
g/100 ml) also found.
Autopsies, 1975-76, Los Angeles
County, CA
CALIFORNIA; AUTOPSIES; CASE
BISTOBIES; BLOOD; DBUG ABUSE; DRUGS;
FORENSIC BEDICINE; ALCOHOLS
Nakanura, S.B.
Noguchi, T.T.
GrieseBer, B.C.
1979
Journal of Analytical
Toxicology 3:137-1»2
00
-------
2,7-(Epoxypentadeca(1,11,1 3) trieniiino) naphtho (2,1-b) f uran-1, 11 (2B) -diooe,
5.6,9,17, 19,2l-hexahydroxy-23-methoxy-2,4.12,16, 18, 20, 22-heptamethyl-8-(N-(4-methyl-l-piperazinyl) f ormimidoyl)-, 21 -acetate (8 CD
Bifamycin, 3- (( (U-uethyl-1 -piperalinyl) imino) methyl) - (9 CD
13292-46-1
CH3-H58-N4-012
nv 822.96, ap platelets fro» acetone 183-188 C (decomp)
TISSUE
Eile
Blood
7471
liver
7172
Orine
EXPOSDBE ROUTE
Ingestion
Ingestion
Inqestion
ANALYTICAL
nETHOD
BPLC
HPLC
•OHBEB
OP CASES
1
1
SANGE
b) Hot applicable
__
_
a) Not applicable
b) Not applicable
c) Hot applicable
a) Mot applicable
b) Hot applicable
c) Not applicable
SEAS
b) 13 +or- 3 ug/mi
a) 373 +or- 75 ug/g
b) 225 tor- 60 ug/g
c) 268 *or- 18 uj/g
a) U75 «oc- 22 iig/nl
b) 31 +oc- 4 ug/al
c) 796 +or- 29 ag/al
SEHEEIL XnrORHlTIOK
t) Hetabolite (3-Fornylrl(a«ycin ST)
8-10 hr after about 15 g overdose
28 yr old suicide victim, «t 7Q kg
Congestion and swelling of brain and
kidneys. Liver abnormalities
ADULTS; SUICIDE: BILE; BLOOD; LIVER;
OBINE; ANTIBIOTICS; DPUG JBUSE;
[BOGS; ALCOHOLS; BETABOLITES
28 yr old suicide victin, wt 70 kg
Severe, acute pulmonary edema.
kidneys. Liver abnormalities
ADULTS; SOICIDE; BILE; BLOOD; LIVEB;
OEIBE; ANTIBIOTICS; DE OG ABUSE;
DBOGS; ALCOHOLS; HETABOLITES
a) Parent coipoucd
b) Metabolite (3-For«ylrif aiycin SV)
c) Metabolite
(25-Desacetylrifaipicin)
8-10 hr after about 15 g overdose
28 yr old suicide victim, vt 70 kg
Severe, acute pulmonary edema.
Congestion and swelling of brain and
kidneys. Liver abnormalities
ADULTS; SUICIDE; BILE; BLOOD; LIVBB;
OBIHE; ANTIBIOTICS; D80G ABUSE;
ERUGS; ALCOHOLS; dETABOLITES
a) Parent compound
b) Metabolite (3-Pormylrif amycin SV)
c) Metabolite
(25-Desacetylrifampicin)
8-10 hr after about 15 g overdose
28 yr old suicide victim, vt 70 kg
Severe, acute pulmonary edema.
Congestion and swelling of brain and
ADULTS; SUICIDE; BILE; BLOOD; LIVES;
UBIHE; ANTIBIOTICS; DBUG ABUSE;
DRUGS; ALCOHOLS; METABOLITES
BEFEBENCE
Battista, H.J.
Unterdorfec, H.
van Ditmarsch, H.c.
Maes, B.&.&.
1981
48:2<45-252
Battista, H.J.
Dnterdorfer, H.
van Ditmarsch, H.C.
Haes, B.A.A.
Archives of Toxicology
48:2»5-252
Plomp, T.A.
Battista, H.J.
Onterdorfer, H.
van Ditnarsch, B.C.
Maes, B.A.A.
1981
Archives of Toxicology
48:245-252
Plomp. T.A.
Battista, H.J.
Unterdorfer, H.
van Ditaarsch, v.c.
Maes, B.A.A.
1981
Archives of Toxicology
48:245-252
-------
2',6'-AcetojylUide, 2- (diethylaBino) - (8 CI)
Acetaiide, 2-(diethylamino)-H-(2,6-diBethylphenyl)- (9 CI)
137-58-6
C1U-H22-H2-0
HW 234.33, SP 68-69 C, BP 180-181 C at 4 B« Hg, 159-160 C at 2
Hg
TISSUE
7173
Blood
7474
Blood
7475
Blood
7176
Blood
EXPOSURE ROUTE
Injection
Infection
Inqestion
Injection
Inhalation
ANALYTICAL
HETHOD
OC
GC
ELISX
RIA
GC/HS
H OH BEE
OF CASES
a) 16
b) 16
9
1
3
BANGE
a) 0.28-0.09 ug/inl
bj 0.01-0. 15 lig/al
_
a) 1.3-0.09 uq/Bl
b) 1.2-0.07 ug/il
a.) Sot applicable
b) not applicable
c) Not applicable
0.01-0.70 »g/ai
HE1N
a) Hot given
b) Not given
a) Mot given
b) Not given
a) 10 uq/n.1
b) 6.3 ug/Bl
c) 0 ug/Bl
Not given
GENERAL IHFOBHATION
a) 120 and 160 sin after 100 eg
spinal injection. Initial
•easurement, 0.15 ug/nl at IS nin
b) 15 and 60 miu after 100 ag with
0.2 tag adrenaline. Fina 1
neasurement, 0.08 ug/nl at 480 Bin
Range of means, estimated from graph
(15-75 yr old hospital patients
undergoing linor operations
BLOOD; ANESTHETICS; DROG INTERACTIOB;
DE0GS
a) Fasting
b) sith food
0.5 and
-------
2R-1.2,U-Benzothiadiazine-7-sulfonaBide, 6-chloro-, 1,1-dioxide
58-94-6
C7-H6-C1-S3-0
-------
2H-1,4-Ben2odiazepin-J-one, 7-chloro-1-(2-(di.ethylamino| ethyl) -5- (o-£luorophenyl| -1,3-dihydro- (8 CI)
2H-l,4-Benzodiazepin-2-one, 7-chloro- 1- (2- (diethylamino) ethyl) -5- (2-fluoropheayl) -1.3-dihydro- (9 CI)
17617-23-1
C21-H23-C1-T-H3-0
BB 387.91
TISSUE
7481
Blood,
plasma
EXPOSUBE BOtJTE
Ingestion
ANALYTICAL
BETHOD
GC
MM BEE
OF CASES
26
BADGE
a) 5.3-19.6 ng/ml
b) 11.5-20.2 ng/ml
c) 8.2-15.1 ng/ml
d) 10.3-19.1 ng/ml
e] 40-65 ng/ml
f) 34-143 ng/»l
g) 63-102 ng/ml
t) 59-151 ng/ml
BEAN
a) 10.2 ng/ml
b) 14.5 ng/ml
c) 11.1 ng/ml
d) 12.4 ng/ml
e) 53 ng/ml
£) 85 ng/ml
g) 81 ng/ml
0) 86 ng/ml
GEHEBAL ISFOBBATIOB
a) 7 young men, mean time to peak 4. 1
hr
b) 7 young women, mean time to peak
23.3 hr
c) 6 elderly men, mean time to peak
28.5 hr d) 6 elderly women, mean time
to peak 17.6 hr
e) Group a) , mean time to
steady-state level 89 hr, 4 subjects
f) Group b) , mean time to
steady-state level 74 hr, 5 subjects
g) Group c) , mean time to
steady-state level 115 hr, 4 subjects
h) Group d) , mean time to
steady-state level 104 hr, 5 subjects
a)-d) peak level desalkylf lurazepam
(metabolite) after single 15 mg dose
e)-h) steady-state level
desalkylf lurazepam after 15 mg
nightly for 15 nights
Time to peak (0.5-96 hr) not
influenced by age
Half-life longer in elderly men than
in young men
So evidence of increased sensitivity
in elderly
19-34 yr old young subjects, and
61-85 yr Old elderly subjects.
Healthy, non-inso»niac.
ADULTS; BLOOD PLASBA; DH0G THEBAPY;
DBUGS; HYPNOTICS; HETJBOLISB;
BETABOLITES
BEFEBEHCE
Greenblatt, D.J.
Divoll, B.
Harmatz, J. S.
BacLaughlin, D.S.
Shader, B.I.
1981
Clinical Pharmacology
and Therapeutics
30(4) :475-486
2H-1,4-Benzodiazepin-2-one, 7-cbloro-1,3-dihydro-1-methyl-5-phenyl-
139-14-5
C16-H13-C1-H2-0
fl» 284.76, HP 125-126 C
TISSUE
7482
Blood
EXPOSDBE RODTE
_
1
ANALYTICAL
BETHOD
ac
TIC
ov
GC/BS
Enzymatic
-
NOBBEB
OF CASES
a) 1
b) 2
c) 3
BASSE
a) 0-2.1 mg/1
b) 0-2.6 mg/1
c) 0-1.0 mg/1
BEAM
a) Not given
b) Not given
c) Hot given
GESEEAL IHFORH1TICH
a) Dose probably sufficient to
contribute to signs and sy»pto«s
b) Doses probably less than toxic
anounts
c) Patients denied taking drag
Results fro* 4 laboratories receiving
overdose drugs identified in 50S-70J6
of cases. Laboratories agreed on 6
of 23 drugs reported present in sera*
of 20 patients
ii precise.
Probable drug overdose patients.
Boston, Ha
HASSACHOSETTS; BLOOD; &H&LGESICS;
AHTICONVULS&NTS; AHTIDEPRE SSI7E
AGENTS; ANTIPYRETICS; DRUG IBflSE;
DEDGS; HYPHOTICS; HiSCOTICS;
SEDATIVES; TB4HQOILIZEBS; COHPAHATIVE
EV&LQ&TIOMS; ALCOHOLS; HEASOREHENT
METHODS
8EPEREHCE
Inge If inger , J . A .
Isakson, G.
Shine, D.
costello, C.E.
Goldnan, P.
1981
Clinical Pharsacology
and Therapeutics
29 (5): 570-575
(BEIT PAGE)
-------
2R-1, '4-Benzodiazepin-2-one , 7-chloro-1, 3-dihydro-1-Bethyl-5-phenyl-
U39-11-5
C16-HI3-C1-S2-0
BW 28H.76, HP 125-126 C
(COHIIHOED)
TISSUE
7*83
?loofl
7484
Blood
7485
Blood
7«8f
Blood,
plasma
7487
Blood,
plasma
EXPOSURE FQOTE
Inqestion
Injection
Inqestion
ANALYTICAL
METHOD
RIA
Fluorometry
GC
GC-EC
8SHBEB
OP CASES
1
10
12
6
110
BADGE
a) Hat applicable
b) Not applicable
0.01-0.09 mg/100 ml
0.6-7.4 ug/ml
a) 570-150 ng/Bl
b) 9-1 ng/ml
c) 7-32 ng/Bl
d) 800-200 ng/ml
e) 12-3 ng/ml
f) 3-15 ag/ml
16-1412 ng/Bl
(NEXT
MEAN
a) 0.9 Bg/1
b) 0.6 mg/1
Not given
Not given
a) Not go. en
b) Not gi en
c) Not gi en
d) Not gi en
e) Not gi en
f) Not gi en
329 *or- 272 ng/al
PAGE)
GENERAL INFORMATION
_
a) Diazepan
b) Nordiazepam
1.2 mg/1 hydrocodone also present.
Reported to have ingested 6 oz
Hycodan (5 mg/5 mi hydrocodone
hitartrate)
35 yr old suicide victim
AUTOPSIES ; SUICIDE; BLOOD; DRUG
ABOSE; DRUGS; POEEHSIC MEDICINE;
MEASUREMENT METHODS
Drug induced fatalities. Ethanol (4
cases, 0.15-0.33 g/100 ml), raethadone
{2 cases, 0.01-0.04 mg/100 ml).
amobarbital {2 cases, 0. 13-0.5 mg/100
ml), methapyrilene (1 case, 0.25
rag/100 ml) , propoxyphene (2 cases.
0.02-0.09 mg/100 ml), and aeperidine
(1 case, 0,02 ng/100 ml) also found.
Autopsies, 1975-76, Los Angeles
County, Cft
CALIFORNIA; AUTOPSIES; CASE
HISTORIES; BLOOD; D RtTG ABUSE; DRUGS;
FORENSIC MEDICINE; ALCOHOLS
Deaths involving diazepam and
morphine (2-31 ug/dl)
Hayne County, HI
MICHIGAN; AUTOPSIES; DRUG ABUSE;
DRUGS; NARCOTICS; PSYCHOTROPIC DRUGS;
SEDATIVES
a) Total diazepam. 20 min and 8 hr
after dose. 160 ag/ml at about H min
b) Plasma free diazepam. 10 min and
8 hr after dose. 15 ng/ml at about 4
inin
c) Plasma total H-desmethyldiazepa m.
t*0 min and 8 l»c after dose
d) Same as a). 240 ng/nl at about 4
din
e) Same as b) - 30 ng/ml at about 4
min
f) Sane as c)
Dcse in a) -c) 10 mg IV. Dose in
d)-f) 10 mg IV, «ith plasma ethanol
level 800-1000 mg/1
Range of means, estimated from graph
Healthy 21-32 yr olds
BICOD PIASOfA; DRUG INTERACTION;
DRUGS; SEDATIVES; TRASQOILIZERS;
ALCOHOLS; DIAZEPAMS
2-^5 fog diazepam/day (Bean 19.9
lag/day) . Correlation with age and
highly significant correlation with
dose.
24-69 yr old psychiatric patients, vi.
DRUGS; BLCCD PLASMA; SEDATIVES; DRUG
THERAPY; METABOLITES; AGS
8EFE8ESCE (
1
Cimbura, G.
Koves, E.
1981
Journal of Analytical
Toxicology 5: 296-299
Nakanura, G.B.
Noguchi , T. T.
Griesemer, E« C .
1979
Journal of Ana lytical
Toxicology 3: 137-14Z
Monforte, J.H.
1977
Sciences 22 (4) :7 18-724
Sellers, E.H,
Haranjo, C.A.
Giles, H.G.
Frecker, B.C.
Beeching, M.
1980
Clinical Pharmacology
and Therapeutics
28(5) :638-645
Greenblatt, D.J.
Laughren, T.P.
Allen, n.D.
Harmatz, J.S-
Shader, P.I.
1981
Clinica 1 Phaca acology
11:35-40
Ui
UJ
-------
2H-1, 4-Bensodiazepin-2-one, 7-chloro-1,3-dihydro-1-»ethyl-5-phenyl-
U39-14-5
C16-H13-C1-N2-0
BB 284.76, HP 125-126 C
(CONTINUED)
TISSUE
7U88
Breath
7489
flrine
EXPOSURE ROUTE
Injection
Injection
iMimau.
HETHOD
Radionetry
Kadionetry
Basses
OF CASES
a) 11
b) 17
c| 15
d) 27
e) 9
a) 11
b| 17
c) 15
d) 9
a) 15-3
b) 11-2
c| 4-13
d) 2-21
e| 11-3
a) Hot
b) Hot
c) Hot
d) Nat
BiHSE
a) 15-38*
b) 11-22*
c| 4-13*
d) 2-21*
e| 11-31*
_
a) Hot given
ta) Sot given
c) Hot given
d) Nat given
BEAK
a) 26.6 tor- 7. IX
b) 14.0 tor- 2.6*
c) 8. 1 tor- 2. 3%
d) 11.1 tor- 3.7S
e) 15.7 tor- 3.3*
a) 14. 1 tor- 2.3*
b) 14.0 tor- 2.5*
c) 3.3 tor- 0.8*
d) 15.5 tor- 6.3S
GENERAL IHFORHATIOH
a) Patients on anticonvulsants
b) Controls
c) Patients «ith hepatocellular
disease
d> Patients with hepatic neoplasn
e) Patients with cholestasis
24 hr excretion of C-14 after 5 uci
differences at 6 hr and later.
Estimated from graph
43-57 yr old hospital patients
Confusion or dysarthria occurred in
hepatocellular disease
EEE»TB; CIRRHOSIS; 1IVER DISEiSES;
DEIHE; SHJIGSSICS; ANTICOH VULS»HTS ;
JBTIPTRETICS; DE06 IKTEBACIIOS:
DROGS; TRiNQOILIZIRS; COBPJRIIIVE
EVJLOHIOBS
a) Patients on anticocvulsants
b) Controls
c) Patients with hepatocellular
disease
d) Patients with cholestasis
24 hr output of C-11 after 5 uCi (5
• g)
43-57 yr olds
Confusion or dysarthria occurred in
one control and 8 patients with
hepatocellular disease
EBEHTH; CIRRHOSIS; LIVER DISEHSES;
OHIHE; JNALSESICS; ANTICOH VOLSABTS ;
ANTIPTRETICS; DRUG INTERACTION:
DBDGS; TR ANOOIIIZER S; COHP4BATIVE
EVALUATIONS
REFERENCE
Bepner, G.H.
Vesell, E.S.
Lipton, A.
Harvey, H.».
Wilkinson, G.R.
Schenker, S.
1977
and Clinical Medicine
90(3) :«40-456
Hepnei:, G.W.
vesell, E.S.
Lipton, i.
Harvey, H. A.
uilkinson, G.R.
Schecker, S.
1977
Journal of Laboratory
and Clinical Medicine
90 (3): 440-4 56
Ln
2H-1, 4-Ben7odiazepin-2-one , 7-cbloro-1,3-dihydro-3-hydroxy-5-phenyl-
604-75-1
C15-H11-C1-B2-02
US 286.74, up 205-206 C
TISSDE
7490
Blood
EXPOSURE ROOTE
AMLrricAL
BETHOD
GC
07
__
NDHBER
OF CASES
1
BA«GE
a) Nat applicable
b) Hat applicable
HEAN
a) 1.6 mg/lOOg
b) 1.0 19/1 OOg
GENERAL INFOEHATION
a) Solvent extraction nethod
b) XAD-2 resin bag extraction Method
Poland
POLAND; BLOOD; BRAIN; LIVES; DRUG
ABUSE; DRUGS; HEASUREHENT SETRODS
REFERENCE
Bogusz, ff.
Gierz, J.
1978b
Forensic Science
International 12:73-82
(NEXT PAGE)
-------
2H-1 ,4-Benzodiazepin-2-one, 7-chloro-l ,3-dihydro-3-hydroxy-5-pnenyl-
608-75-1
C15-H11-C1-H2-02
«» 286.74, «P 205-206 C
(COHTIHBEDI
TISSUE
7191
Blood,
plasna
7
-------
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dittydro-3-uydroxy-1-methyl- (8 LI)
2H-l,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)- l,3-4iaydro-3-hydroxy-l-iiethyl- (9 CI)
818-75-9
C16-H12-C12-N2-02
SB 335.20
7095
Blood,
plasma
71(96
Urine
EXPOSURE ROUTE
Ingestion
Ingestion
ANALYTICAL
HETHOD
RIA
SUflBER
OF CASES
a) 2.7-0.2 ng/nl
b) 2.11-0. 1 ng/ml
c) 34-52 ng/ml
d) 37-48 ng/ml
a) Hot given
b) Hot given
a) Sot given
b) Not given
c) Hot given
d) Hot given
a) OK of dose
b) 3.8X of dose
GENERAL INFORMATION
a) 2 and 24 hr iiith hemodialysis
treatment
b) 2 and 24 tic without heaodialysis
c) 2 and 8 hr, glucuronide
metabolite, without hemodialysis.
Final measurement 39 ng/ml at 48 hr
d) 2 and 12 hr, glucuronide
metabolite. Hith hemodialysis.
Final measurement 40 ng/ml at 48 hr
After 1 mg dose
Hemodialysis 1-4 or 5 hr after dose
Range of means, estimated from graph
36-65 yr old patients with terminal
renal failure
Drug biotransfornation unaltered, but
glucuronide metabolite cumulates by a
factor of 5 to 6 as a result of
urenia
ADULTS; KIDNEY DISEASES; BLOOD
PLAS1A; 08INE; DBOS TREHAPY; DBOGS;
SEDATIVES: coifPiSArrvE EVAIUATIOHS:
HFBODIALYSTS: BESZODIAZEPIBES;
GERBANY
a) 48 hr cumulative output
b) 48 hr cumulative output,
glucuronide netabolite
After 1 mg dose
3(-tS jr old patients vith terminal
renal failure
Drug biotransforaation unaltered, but
glucuronide metabolite cumulates by a
factor of 5 to 6 as a result of
uremia
ADULTS; KIDHET DISEASES; BLOOD
PLASBA: OEI8E; DBOG THERAPY; DRDGS;
SEDATIVES; COBPAEATI7E EVALUATIONS;
HFBODIALYSIS; BENZODHZEPIKES:
GERMANY
Kampf, D.
Huempel, H.
Lerche, 0.
Kessel, ».
1981
Clinical Pharmacology
and Therapeutics
30(1) :77-85
Kampf, D.
Huempel, fl.
terche, a.
Kessel, M,
1981
Clinical Pharmacology
and Therapeutics
30(1) :77-85
-t-
Ul
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorphenyl)-1,3-dihydro-3-hydrojcy- (8 CI)
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy- (9 CI)
846-49-1
C15-H10-C12-N2-02
BS 321.16, BP 166-168 C
TISSUE
7497
Amniotic
fluid
EXPOSURE 800TE
Injection
Ingestion
ANALYTICAL
BETHOD
GC-EC
»t/»BES
OF CASES
23
IMSE
a) Not given
b) Hot given
c) Not given
d) Not given
HEAN
a) 2.0 *or- 2.2 ng/ml
b) 4.9 +or- 3.0 ng/ml
c) 4.2 »or- 2.3 ng/ml
d) 19.1 +or- 13.0
ng/ml
GENERAL IKFOEttUTION
a) 0-2 hr after 2.0 ng IH.
Unconjugated
b) Save as a). Conjugated
c) 11-15.5- hr after 2.5 mg, oral.
Onconjugated
d) Saae as c) . conjugated
Healthy pregnant voaen
FETOS; BIOOD SEBDM; ORINB; DBOG
THE8KPY; DRQGS; SEDHTI7ES; PBEGS1HCY 1
Kanto, J-
Aaltonen* L.
Liukko, P.
Naenpaa, K.
1980
4cta pharaacologica et
Toxicologica 47:130-134
PAGE)
-------
2H-1,G-Benzodiazepin-2-one , 7-chloro-5-(o-chlorphenyl)-1,3-dihydro-3-hydro*y- (8 CI
2H-1,W-Benzodiazepin-2-one, 7-chloro-5- (2-chlorophenyl)-l,3-dihydro-3-hydroxy- [9 CI)
8H6-49-1
C15-H10-C12-S2-02
HS 321.16, SP 166-168 C
(CONTINUED;
TISSUE
7U98
Blood,
serum
EXPOSURE POOTE
i
Injection
Ingest ion
ANALYTICAL
HETHOP
GC-EC
H OH BEE
OF CASES
23
BAHGE
a) Hot given
b) Hot given
c) Hot given
d) Not given
e) Hot given
f) Hot given
g) Hot given
h) Hot given
i) Hot given
j) Hot given
fc) Hot given
1) Hot given
HEAK
al 8.1 +or- 3.4 ng/al
b) 18.1 +or- 17.2
ng/ml
c) 7.0 +or- 2.3 ng/ml
d) 33.9 +or- 23.7
ng/mi
e) 7. 1 +or- 2.7 ng/ml
£) U. 6 +oc- 3.8 nq/Bl
g) 8.8 +or- 5.6 ng/ml
li) 23.5 +or- 11.7
ng/ml
i) 6.9 + or- 2.0 ng/ml
^) 4.8 +or- 3.6 ng/ml
k) 8.7 + or- 3.6 ng/ml
e) 25.4 +or- 13.3
ng/ml
GENERAL INFORMATION
a) 0.8-7.7 hi after 2.0 og IB.
Maternal vein. Onconjugated
b) Sane as a) . Conjugated
c) 11-15.5 hr after 2.5 ig oral.
laternal vein. Unconjugated
d) Sane as c) . Conjugated
e) Same as a). Umbilical vein
f ) Sa e as b) . Umbilical ein
g) Sa e as c) . Umbilical ein
h) Sa e as d) . Umbilical ein
i) Sa e as a). Umbilical ctery
1) Sa e as b) . Umbilical rtery
k) Sa e as c) . Umbilical rtery
1) Sane as d) . Umbilical rtery
In a) , b) , e) , f ) , i) and 1) dose
given during first stage of labor.
In other cases dose given night
before elective cesacean section
Healthy pregnant women
FFTOS; BLOOD SERUH; OPINE; DRUG
THERAPY; DfcUGS; SEDATIVES; PBBGHXHC?
REFERENCE 1
Kanto, 3.
Aaltonen, L.
Liukko, P.
Maenpaa, K.
1980
Acta Pliarmacologica et
Toxicologica 17:130-134
3-Heptanol, 6- (dimethylainino) -1ri*-diphenyl-, acetate (ester) (8 CI) (VAN)
Benzeneethanol, beta-{2-(dimethylanino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester) (9 CI) (VAN)
5C9-74-0
C23-H31-N-02
BB 353.U9, HP 193-217 C
TISSUE
Blood,
plasma
EXPOSURE ROUTE
ANALYTICAL
METHOD
NUltBEE
OF CASES
EAN6E j
b) 70-260 ng/ml
c) 40-170 nq/ml
BEAN
b) Not given
c) Not given
GENEBU IHFOR BATICN
0.73-0.92 >g/kg/08 hr. 70 ng/il on
0.73-0.92 ngAg/118 hr. 220 ng/«l on
day 19. Metabolite
(dinorace t?l»ethatiol)
c) 3 and 13 days after start of
0.73-0.92 »cjAg/U8 hr. 1»0 cg/il on
day 19. Hetabolite
(noracetylmethadol)
Pange of neans, estimated from graph
Treatment began 2H hr after
discontinuation of methadone
Patients on methadone maintenance
program
BIOOD PLASHA; DBOG THEEAPY ; DRDGS;
NABCOTICS; COBPAEATIVE EVAIOATI011S
EEFEBEDCE
weinberg, J.A.
Hargreaves, H.A.
Lau, D.H.H.
Tyler, J.
Balcerr B.
1977
Journal of Analytical
Toxicology 1(1) : '-5
-------
3-Heptanone , 6-(dinethylagino)-4,4-diphenyl-
76-99-3
C21-H27-N-0
US 309.49
TISSUE
7500
fluid
7501
Jnniotic
7502
Bile
7503
EXPOSURE ROCTE
Ingestion
Ingestion
Ingestion
ANALYTICAL
BETHOD
GC
GC
GC
GC
av
GC/HS
Enzyiatic
8 On BEE
OP CASES
10
14
1
1
RANGE
0.07-0.39 ug/»l
0.01-0.67 ug/ll
a) 0.23-0.08 ug/»l
b) 119.5-24.1 ug/ll
c| 0. 1 1-0. 03 ug/ll
0-0.4 »g/l
BEAN
Not given
0. 20 ug/ll
a) Not given
b) Not given
c) Wot given
Hot given
GENERAL INFORHATIO"
Dose 30-100 ag/day, 1 sanple/subject.
0.14-0.48 ag/ml. Aiiniotic fluid to
Patients on aethadone
Severe withdrawal syiptow-s in sone
newborns
»EW TOEIC; 9IKBOBN; JfllllOTIC FLD10:
BtOOD PLASIU; nilK; DEINEj DSOG
•IHESiPI; DRUGS; NARCOTICS; LACTATION;
PREGNANCY
Dose 5-60 mg/day
All Infants of aethers on aethaione
at tide of delivery exhibited
withdrawal syBptoas. Severity
positively correlated vith total
•aternal dose during last 12 vk of
pregnancy, daily dose at delivery.
and intra par tarn sera* level.
HEHBOBH; ftHHIOTIC FLUID; BLOOD;
OBISE; DSDG THERiPT; DRUGS
a) Hethadone
b) Pyrrolidine, netabolite of a)
c) Pyrroline, aetabolite of a)
0-6 and 18-24 hr after 100 ng
60 yr old surgical patient
BILE; BLOOD PL AS HA; DRUG THEBXPT;
DRUGS; NAKCOTICS; METABOLITES
Dose probably less than toxic a»oant
identical saiples for toxic screen
overdose drags identified in 50X-70X
of cases
Laboratories agreed on 6 of 23 drugs
reported present in serai cf 20
patients
Levels were variable and appeared
imprecise.
Probable drug overdose patients.
Boston, HA
niSSACHOSETTS; BLOOD; AHALGESICS;
ANTICONVOL5ANTS ; ASTIDEPRE SSI VE
AGENTS; ANTIPYRETICS; DRUG ABUSE;
DHUGS; HYPSOTICS; HARCOTICS;
SEDATIVES; TRiBQUILIZEBS ; COHPA8ATI7E
EVALUATIONS; ALCOHOLS; HEaSUBZHBHT
METHODS
REFERENCE
Blinick, G.
Jerez, E.
1975
Gynecology
121 (5) :617-621
Harper, R.G*
Solish, G.
Sokal, B.n.
1977
Gynecology 129:417-424
Kreck, «.J.
Kalisian,
-------
3-Heptanone, 6- lauethylaiino) -U.it-a
76-99-3
C21-B27-B-0
HI 309.19
(CO»TISUED>
TISSUE
7504
Blood
7505
Blood
7506
Flood
7507
Blood
7508
Blood,
fetal
EXPOSOBE RODTE
Infection
Ingestion
Ingesiton
ASJLtTICAL
tlETHOD
GC
GC
SC
GC
BOBBER
OF C1SES
a) «
b) 4
1
2
H\ 6
b) 4
C) 6
19
BANGS
a) 42-1 ug/ml
b) 420-180 ng/nl
a) 95-50 ug/al
b) 6.7-3.7 ng/iil
0.01-0.04 mg/100 ml
A) 35-5.2 ng/nl
b) 25-6 ng/atl
c) 15-3,5 ng/ml
0-0. 12 ug/al
MEAN
a) Not given
b) Hot given
a) Not given
b) Not given
Not given
a) Not given
b) Sot given
c) Not given
0.05 ug/al
GENERAL INFORMATION
a) Won addicts. 1 and 24 hr after 10
•g/1.79 sg a, IM, as hydrochloride.
Haxinun in gastric fluid 2800 ng/nl
at 3 hr
b) Ex-heroin addicts on lethadone. l
and 24 hr after 53.7-80.5 mgr in, as
hydrochloriae. Haxiaua in gastric
fluid 28000 ng/Bl at 2 hr
Range of Beans estimated froa graph
Healthy subjects betveen 20 and 30 yc
BLOOD; SALIVA; DFOG AEOSE; DROGS;
NAPCOTICS
a) Hethadone, 2 and 24 he after 75
ng. Initial measurement, 67 ng/nl
t> Pyrrolidine metabolite tor a) , 4
and 24 hr. Initial measurement, 4.0
ng/nl
lethadone maintenance patient
BIOOD; DROG THESAPY; DRUSS;
NARCOTICS; MEASOEEHEST HETBODS;
HETABOLITES
Drug induced fatalities. Ethanol,
Autopsies, 197^-76, Los Angeles
Ccunty, CA
CALI?ORNIA; AUTOPSIES; CASE
HISTORIES; BLOOD; DRUG ABOSE; DRSGS;
FOREHSIC MEDICINE; ALCOHOLS
a) 2 and 72 hr after 15 ng
d,l-methadone. 30 ng/ml at 1 hr
d-iaethadone, 22 ng/ml at 1 hr
c) 2 and 72 hr after 7.5 mg
1-nethadone. 13 ng/nl at 1 hr
Range of means, estimated f ron graph
a) and c) had greater effects on
respiration
Healthy 21-35 yr olds
Antidiarectic effect
BLOOD; ANALGESICS; DROGS; NARCOTICS;
COHPABRTIVE EVALUATIONS
Haternal daily dose 5-60 ng.
mothers
All infants of aethers on lethadone
at time of delivery exhibited
withdrawal syaptons. Severity
positively correlated with total
pregnancy, daily dose at delivery,
and intrapactnm serun level.
NEWBORN; AMHIOTIC FLUID; BLOOD;
URINE; DRUG THERAPY; DROGS
REFERENCE
Lynn, R.K.
Olsen, G.D.
Leger, R.H.
Gordon, fl.P.
Slith, E.G.
Gerber, N.
1975
Drug Metabolism and
Disposition
4 (5) :504-509
Jacob, P.
Rigod, J.F.
Pond, S.H.
Benowitz, N.L-
1981
Journal of Ana ly tical
Toxicology 5:292-295
Nakaniira, s.B.
Noguchi , T. T.
Grieseaer, B.C.
1979
Journal of Analytical
Toxicology 3:137-142
Olsen, G.D.
Mendel, H.A.
Livereore, j. D.
Leger, H.H.
Lynn, R.K.
Gerber, N.
1977
Clinical Pharmacology
and Therapeutics
21 (2) : 147-157
Harper, P.S.
Solish, G.
Feingold, E .
Gersten-Hoolf , N-B.
Sokal, N.M.
1977
Obstetrics and
Gynecology 129:417-424
(BEIT P4GE)
Ul
VO
-------
3-Heptanone, 6- (dimethylamino) -4,4-diphenyl-
16-99-3
C21-H27-N-0
BS 309.09
(CONTINUED)
TISSUE
7509
B 1 o od f
plasma
7510
Blood ,
plasma
7511
Blood,
plasma
7512
Elood,
plasma
7513
Blood,
plasma
EXPOSURE HOOTE
Ingest ion
Ingestion
Ingestioo
_
Ingestion
ANALYTICAL
HETHOD
GC
GC
GC
GC
.
GC
NUBBER
OF CASES
13
11
25
11
1
RANGE
a| 0.18-0.53 ug/ml
b) 0.08-0.28 ug/ml
c| 0.02-0.53 ug/»l
149-53 ng/ml
a) 0.14-0. "48 ug/ml
b) 0.05-0.38 ug/ml
c) 0.04-0.25 ug/ml
d) 0.06-1.66 ug/ml
40-420 ng/nl
0.90-0.42 ug/ml
(HEX!
1 BEAN
a) 0. 358 ug/nl
b) 0. 179 ug/ml
c) 0.377 ug/ial
Not given
a) Not given
b) Hot given
c) hot given
d) Not 'given
Sot given
Hot given
P&GE)
GENERAL INFORMATION
a) 3 reliable patients, stead? state
level. Mean daily dose 1. 13 ng/fcg
b) Sane as a) following one day dose
anission
c) 10 patients at clinic, randon
selection. Mean daily dose 1.25
»g/kg
prescribed dose not taken.
Methadone maintenance patients
BLOOD PLASMS; DRUG THERAPY: DRUGS;
NABCOTICS
1 and 5 days after discontinuation of
0.62-1.00 mg/kg/day
Patients on methodone Maintenance
program
B100D PLASMA; DEOG THEBAPY; DRUGS;
NARCOTICS; COBPARATIVE EVALUATIONS
a) Dose 30-100 mg/Say. 14-40 »k
gestation. Amniotic fluid levels
0.07-0.39 ug/ml (10 cases)
b) Hose 40-100 ag/aay. 38-41 uk
gestation (12 cases)
c) Umbilical cord plasma for b) .
Bean ratio of c) to b) 0.57
d) Dose 10-80 Big/day, 3-10 days
postpartum (10 cases). Levels in
.ilk 0.05-0.57 ug/ml
Patients on methadone
Severe withdrawal symptoms in some
newbocns
NEW rORK; SEBBORS; A9NIOTIC FLOID;
BLOOD PL1SH1; BILK; MINE; DRUG
TBERiPY; DROGS; NARCOTICS; LACTiTIOS;
PREGSJNCY
Dose 20-85 »g/day. Beekly
measurements over 5-28 wk. Dose self
adjusted (as much as 5 mg/wk) . Large
fluctuations in plasma levels per
given dose. No relationship between
plasma level and symptom complaints.
Patients in methadone treatment
program
BLOOD PLASH J; OBDG THERAPY; DRUGS;
NARCOTICS
3 and 2« hr after 100 «g. 0.6H ug/ml
at 2 hr
60 yr old surgical patient
BILE; BLOOD PLASBA; DROG THERAPI;
DRUGS; NARCOTICS: BETJBOLITES
REFERENCE
Verebely, K.
Kutt, H.
1975
Research communications
in chemical Pathology
and Pharmacology
11 (3) :373-386
Henderson, G.I.
Weinberg, J.A.
Hargreaves, U. A.
Lau, D.H.fl.
Tyler, J.
Baker, B.
1977
Journal of Analytical
Toxicology 1(1) : 1-5
Blinick, G.
Inturrisi, C.E.
Jerez, E.
nallach, B.C.
1975
American Journal of
Obstetrics and
Gynecology
121(5) :617-621
Horns, ».B.
Rado, fl.
Goldstein, A.
1975
Clinical Pharmacology
and Therapeutics
17(6) :636-649
Kreck, B.J.
Kalisman, fl.
Irwin, «.
Jaffery. ».F.
Scheflan. a.
1980
Research Communications
in Chemical Pathology
and Pharmacology
29 (1) :67-78
-p-
ON
O
-------
3-Heptanoner 6-{
T6-99-3
C21-H27-N-0
H« 309.49
(COHTIH01D)
TISSOE
751U
Blood,
serum
7M5
Milk
7516
Saliva
7^ 17
Urine
EXPOSURE ROUTE
Ingestion
I n q es t io n
Infection
Ingestion
ANALYTICAL
METHOD
GC
GC
GC
_
GC
)
1 !
NUMBER
OF CASES
20
10
a) U
b) 4
6
RANGE
0-0.66 uq/al
0.05-0.57 ug/ml
a) 28-63 ng/ml
b) 2500-420 ng/ol
a) 7.4-33% of dose
b) 9.6-22% of dose
c) Sot applicable
d ) Sot applicable
e) Mot applicable
f ) Hot applicable
g) 2.9-2456 of dose
h) 14-43* of dose
MEAN
0.19 ug/inl
Not given
a) Not given
b) Not given
a) Not given
b) Hot given
c) 28% of dose
d) 14% of dose
e) 1 1% of dose
f) 11% of dose
g) Not given
' Not given
i -i
GENERAL INFORMATION
Maternal intrapartum serun. Daily
dose 5-60 ng.
Methadone-aaintained mothers
positively correlated with total
naternal dose during last 12 vk of
pregnancy, daily dose at delivery.
VEHBOEN; AMNIOTIC FLUID; B100D;
URINE; PROG THERAPY ; DRUGS; NARCOTICS
Dose 10-80 mg/day, 1 sample/subject.
3-10 days postpartum. Mean nil* to
plasma ratio 0.83
Patients on nethadone
Severe withdrawa 1 symptoms in some
nevborns
NEW YORK; VEHBOSN; AMNIOTIC FLUID;
ELCOD PLASMA; MILK; OPINE; DRUG
THERAPY; DROGS; NARCOTICS; LACTATION;
PREGNANCY
a) Nonaddicts, 0.5 and 3 hr after 10
rag/ 1.79 sq m, IM, as hydrochloride.
Final measurement 45 ng/ml in 7 hr
b) Ex-heroin addicts, 3 and 7 hr
after 53.7-80.5 ag, IM, as
hydrochloride. Initia 1 measurement
960 nq/ml at 0.5 hr
Bange of means estimated from graph
Healthy subjects between 20 and 30 yr
BLOOD; SALIVA; DRUG ABUSE,- DRUGS;
NARCOTICS
a) 10 rag/day (5 subjects)
b) Same as a) , metabolite
(2-ethylidine-l, 5-dimethyl-3, 3-diphen
ylpyrrolidine(M-l) J
c) 25 mg/day (1 subject)
d) Same as c) , M- 1
e) 50 mg/day (1 subject)
f) Same as e) , H- 1
q) 80 mg/day (5 subjects)
h) Same as gj , M- 1
Mean daily output for 5 day periods.
Ratio of M- 1 to met had one increased
with increasing dose. Six other
20-30 yr old detoxified opiate
addicts , Sweden
REFERENCE
Harper, E.G.
Solish, G.
Feingold, E.
Gersten-Woolf , N.B.
Sofcal, H.M.
1977
Obstetrics and
Gynecologv 129:417-424
Blinick, G.
Inturrisi, c. E.
Jerez, E.
Hallach, H.C.
1975
Obstetrics and
Gynecology
121 (5) :617-621
Lynn, R.K.
Olsen, G.D.
Leger, R.M.
Gordon, W.P.
Smith, R.G.
Gerber, N.
1975
Drug Metabolisn and
Disposition
4(5) :504-509
Anggard, E.
Gunne, L.-H .
Holnstrand, J.
McMahon, R. E.
Sandberg, C.-G .
Sullivan, H.R.
1975
Clinical Pharmacology
and Therapeutics
17 (3) :258-266
;
OPINE; DRUG THERAPY; DRUGS;
NARCOTICS; METABOLITES; SWEDE!'
(NEXT
-------
''5 IB
'J r i at
7519
Orine
rnq^j.on
1
GC
GC
!9
30
1) J . ,SC;-.19. V ug/Dll
Dl ). 12 <>.07 uq/ui
c| ,. U-r.5J jq/Bl
J) J. '0-3-01- ug/ml
a) 0.095-6.2 ug/«l
b) 0.01-15 ng/ml
r n v e -i
SL i jiven
; V't civen
1 f*.>t given
a) 1.49 ug/ml
b) 4.08 ug/ml
3,5-pyrazolidinedione, «-butyl-1,2-diphenyl-
5C-33-9
C19-H20-B2-02
HS 308.37, IIP 105 C
1 c)
I -1)
Severe w it h draw a 1 symptoms in sotae
newborns
NEW TORK; V5XBORN; AMNIOTIC FLUID;
BLOOD PtASIA; flILK; URINE; DRUG
THEPAPY; DHDGS; NARCOTICS; LACTATION;
PEEGNAWCY
A a* r ic a n J o u r n a _ o t
^-tjsttitrics -and
Gvr.ecol.agy
121 f5) :617-621
a) 16 newborn of methadone-naintained
mothers. Maternal dose 5-60 ng/flay
b) 14 Mothers
All infants of mothers on aethadone
at time of delivery exhibited
withdrawal synptoms. severity
positively correlated vith total
naterual dose during last 12 «k of
pregnancy, daily dose at delivery,
and intrapartum serun level.
NEWBORN; AHNIOTIC FLUID; B100D;
URINE; DRUG THERAPY; DPOGS
Harper, E.G.
Solish, G.
Feingold, S.
Gersten-WooIf, S.B.
Soltal, H.M.
1977
A ne r ic a n Jo ur n al of
Obstetrics and
Gynecology 129 :t 17-H24
4>-
&
N3
TISSUE
7520
Blood,
plasaa
EXPOSOHE EOOTE
Ingestion
ANALYTICAL
HETHOD
HPLC
sanBEB
OF CASES
6
StHSE
a) 83-98 mg/1
b) 81-112 mg/1
c) 75-115 mg/1
SEHH
a) Not given
b) Sot given
c) Not given
_
SBHESAL IHFORHATIOS
a) Total phenylbutazoner after 200
mg/day. Unbound fraction 0.8-2.4
mg/1. Oxyphenbutazone (OPB) level
8-23 mg/1
b) -After 300 mg/day. Unbound
fraction 1.7-3.1 mg/1. OPB 7-18 mg/1
c) Total pbenylbutazone, after 400
mg/day. unbound fraction 2.2-5.0
•9/1. OPB 5-15 ug/1
steady-state levels
Estimated from graph
56-65 yr old rheumatoid arthritic
patients
RHEUMATOID ARTHRITIS; BLOOD PLASHA;
A»TI-IllPLA»aATORT AGESTS; DRUG
THERAPY; DROSS
Hi
Aa
Ho
LT
80
19
Br
cl
12
C.
Aarons, L.
Holt, P.J.I.
B.
Rowland, S.
1981
British Journal of
Clinical Pharmacology
12:123-129
-------
3H-l,»-Benzodiazepine, 7-chloro-2-(iethyla«ino) -5-phenyl-, 1-oiide (SCI)
3H-1,1-Benzodiazepin-2-a«ine, 7-chloro-H-Bethyl-5-phenyl-, 1-oxide (9 CI)
56-25-3
C16-H11-C1-N3-0
fl» 299.75, HP 236-236.5 C
TISSOE
7521
Blood
7522
Blood,
plasma
EXPOSURE ROUTE 1 ANALYTICAL
Ingestion
HBTHOD
GC
TIC
0V
Gc/ns
Enzynatic
HPLC
sun BEE
or CASES
a) 1
b) 1
a) 1
b) 1
SUBGE
a) 1.2-9.1 «g/l
b) 0-0. 1 »g/l
a) 1.30-0.040 ug/.l
b) O.OH6-0.11 ug/>l
0) 1.30-0.053 ug/»l
d) 0.056-0.10 ug/«l
BEAU
a) Not given
b) Not given
a) Not applicable
b) Not applicable
c) Not applicable
d) Not applicable
GENERAL I»TOBB»TION
a) Dose probably less than toxic
amount
b) Patient denied taking drug
Results froi 4 laboratories receiving
identical saaples for toxic screen
Cverdose drugs identified in 50K-70*
of 23 drugs reported present in sertla
of 20 patients
Levels variable and appeared
imprecise.
Probable drug overdose patients.
BostoUi HA
IHSSACHOSETTS; BLOOD; ANALGESICS;
AHTICONVtJLSAHTS; JNTIDEPEESSIVE
AGENTS; ANTIPTSETICS; D80G ABOSE;
DBOGS; RtPNOTlCS: NARCOTICS;
SEDA1HES; T»»»QnH,IIESS; COHPARXTI7E
BV«lt/*TIO»S; ALCOHOLS; HEASOKEHEKT
METHODS
a) 0.5 and «8 hr, <0.0eth»lphenyl)- (9 CI)
72-114-6
C16-B11-N2-0
B» 250.29, HP 120 C, also given as 111-116 C
TISSOE
7523
Blood
7521
Blood
EXPOSURE ROOTS
Injection
Inhalation
ANJIYTICAL
HETHOD
GO/US
0V
RIA
GC/BS
NOKEER
OF CJSES
3
2
BANGE
Not detected- 19 ig/1
0.01-0.30 og/dl
BEAN
Not given
Rot given
GENERAL INFORMATION
Suicide victias. Dose unknown.
ADIOPSIES; SOICIDE; BLOOD; LIVER;
OPINE: DHOG ABUSE: DROGS;
BETABOLITES; SWEDEN
Suspected cocaine overdose fatalities
26 and 36 yr old, Los Angeles county.
CA
CALIFOPNIA; AUTOPSIES; BILE; BLOOD;
URINS; DRUG ABUSE; DROGS; NARCOTICS;
FORENSIC MEDICINE; INHALATION
Bo
Ma
Ry
19
CI
20
Ha
No<
19
CI
Bonnichseo, B.
Jarde, Y.
lyhage, 6.
197H
CliDical Chemistry
20 (2): 230-235
Hakanara, G.R.
Hoquchi, T.T.
1981
Clinical Toxicology
:895-905
I SETT
-------
also yiiren as IH-11S C
(CONTINUED)
> "7-j ;s~T~
|
\
i rlv y'
<
1
1
1
S
i 1526
I Liver
1
1
1
1
1
1
1 7527
1 Urine
1
1
!
i
i
i
1 7528
1 tTrine
1
1
1
1
1
i
1
1
I
i
i
1
I
!
I
;
1
1
1
1
!
i
(
1 7529
1 Urine
r
S
S
£
J
1 7530
1 Urine
(•:* ^.;">~r: FouYr \ ~~ ', ^LYTT^AI ' lii/u^i;
; HETHOL ' 0? CAdES
r i
ri-:-~.^ori f V! ( 5J
1 s :
'
i ,
[
1
1 GC/HS | 3
1 t>V !
I 1
I 1
1 1
1 1
1 1
1 1
1 GC/WS | 3
1 0V 1
! 1
1 1
\ I
I 1
| |
I !
Ingest ion I GC I a) 1
1 1 W 1
1 1 c) 1
1 1 d| 1
1 1 el 1
1 1
1 I
1 !
{ 1
1 1
i 1
1 !
! 1
: i
i 1
i !
1 1
! '
! 1
! i
c E
1
i 't
[ t
Inqestior j GC/NS ) 3
! 1
<
5
|
?
Ingestior. . ; t
SilHJE !
i
1
1- - rq '1 5 «
!
5
'
,
i
Not detected-84 »g/kg i Not
[
£
1
|
1
1
1
i
1
;
i
i
a) Not given I a|
b) Hot given I b)
c) Hot given I c)
d) Hot given I d|
e) Hot given t e)
i
1
1
j
!
!
1
!
;
I
i
!
I
*
t
a) 0. 114-0. 28% of dose i al
b) 29-44* of dose I b)
0.57-0. 16 ug/ml I Not
d£iU,F < GZCrT^i. Ifs'O.'n.Vj'le.' j
i '•
I 1
or- 3 mg/I » Cat.es aocaaent-el- San Diev,o nost-it-i
i q 1
' 13-52 yr olds (mean 27 yr) , c.. !
( '
J Depressed level of consciousness (a. (
1 levels >9 rag/1) . Tachycardia
i dysarthna, hypoief lexia, nystagmus, s
1 mydriasis, ataxia
I CSIIFORHIA; BLOOD SEEUB; DRUG ABUSE: >
I DRUGS; HYPNOTICS; SEDATIVES '
{ B
given 1 Suicide victims. Dose unknown. 1
) \
I AUTOPSIES; SUICIDE: BLOOD; LIVER; I
| USTNS; DEUG ABUSE: DBUGS; |
| METABOLITES; SBEDEB |
1 1
I i
1 I
1 1
1 AUTOPSIES; SUICIDE; BLOOD; LIVER; |
1 URISE; DRUG ABUSE; DRUGS; HETABOLITES |
1 1
J t
I I
! !
35.01 mg I a) 2*t hr cunulative excretioc after (
67.17 mg } 300 tog |
35.28 nig 1 b) S^ie as a) {
34.20 og t c) Sane as a) t
80.50 mg I d) 2H hr emulative excretion after f
1 last dose (2 300 mg tablets taken 21 (
I hr apart) j
1 e) Same as d) |
| Total for 5 netabolites. TJata also (
i given for individual metabolites. 5
I 2-nethyl-3-f 2- (hydroxymethyl) phenyi;]- t
| H (3H) -quinazolinone, and (
J 2-Bethyl-3-(2-»ethyl-4-hydroiyphenyl) E
1 -1 (3H) -quinazolinone were the j
( principal netabolites \
i
\ Health volunteers ;
, !
] Drowsiness began 45 >in after i
{ ingestion and persisted 3 hr. '
I Sluctred speech in some individuals. r
1 OEINfi; DRUGS; HAECOTICS; {
| TRUHQOILIZEBS; HETABOLITBS
j ,
Not given 1 a) Unmetabolized drug [
Not given i b) 5 metabolites I
( 70 hf cunulative output after 200-400 !
1 ag dose t
1 Data also given for individual f
1 metabolites I
1 Estimated from graph
1
| DEIHJ; DEUGS; HIPHOTICS; HETABOLITES ,
1 ._ ... i
given E 2 and 26 hr after 250 mg as 1
| hydrochloride 1
T^'l 3FiE?;Ce,
3-'.' /
Jourual o.; fmaiytj.: .:
Toxicology 5:279-20'
Bonn ich sen, R.
Sarde, I.
Byhaqe, B.
1974
Clinical Chemistry
20(2):230-235
8arde, r.
Ryhage, R.
1974
20(2) :230-235
Kazyak, L.
Kelley, J.A.
Cella, J.i.
Droege, R.E.
Hilpert, L.R.
Permisohn, B.C.
1971
Clinical chemistry
23 (11) -.2001-2006
i
I
I
i
i
Ericsson, 0, :
Danielsson, B.
1977 :
Drug netabolism and
Disposition ;
5(61:497-50; ;
Tilstone, W.J. ;
Beavey, P.C.
! Healthy volunteer
:
I OBIH5; DBUGS
I 197:
f Clinical Pharmacology
i and Therapeutics
I
-------
i4-0xa-l-azabicyclo(3.2.0) hEptane-2-carboxylic acid, 3- (2-hydroxyethyiidene)-7-oxo-, (2E- (2alpha,3Z,5alpha)) -
58001-UI4-8
C8-H9-N-05
B« 199.18
TISSUE
7531
Blood,
serum
7532
Cerebrosp
inal
fluid
EXPOSURE ROUTE
Ingestion
Ingestion
ANALYTICAL 1 NUMBER
METHOD i OF CASES
Microbiological ) 21
I
I
I
I
I
Microbiological I
1
I
1
1
1
1
1
BASSE
4.3-0.3 mg/1
a) 0.«-2.0 mg/l
b) 0.2-0.5 mg/l
ilEAH
Not applicable
a) Not given
b) Not given
GENERAL IHFOBHATICN
1 and 6 hr after 250 mg, oral.
Initial measurement 1.5 mg/l at 0.3
hr
BLOOD SERUM; CEREBBOSPISAL FLUIC;
DEUGS
a) 0.5 and 14 hr after 250 mg. Final
measurement 1.6 «g/l at 6 hr
b) 2 and 6 hr after 250 mg
Estimated from graph
BLOOD SEBUM; CEB EBHOSPINAL FLUID;
DRUGS
_
REFERENCE
lunch, R.
Luthy, a.
Blaser, J.
1981
Journal of
Antimicrobial
Chemotherapy 8:29-37
Munch, B.
Luthy, R.
Blaser, J.
Siegenthaler, «.
1981
Journal of
Antimicrobial
Chemotherapy 3:29-37
t-Thia-1-azabicyclo (3. 2. 0) heptane-2-carboxyJ.ic acid, 6-(2-ammo-2- (p-hydroxyphenyl) acetamido) -3,3-dimethyl-7-oxo-, D- (8 CI)
l-Thia-1-azabicyclo (3. 2.0) heptane- 2-carboxylic acid, 6-( (amino (<4-hydroxyphenyl) acetyl) ammo)-3, 3-dimethyl~7-oxo, (25- <2alpha, 5alpha, 6beta fs*() ) - (9 CI)
16767-78-0
26767-78-0
C16-H19-N3-05-S
KV 365.M, MP 191 c (beta-Naphthalenesulfonate trihydrate)
I
| TISSUF
1
1
I
| 7533
| Bile
1
1
1
1
1
|
1
1
1
1
1
1
I
1
1
1
|
I
1
1
1
1
| 7531
( Blood,
( serum
!
1
l
i
:
i
i
i
i.
(
i
i
EXPOSURE POUTE
In jec tion
Infection
ANALYTICAL
(fETHOD
Microbiological
_
Microbiological
HUMBEB
or CASES
22
a) 9
b) 10
c) 13
d) 9
_
BASSE
.
a) 3.7-7.8 u/ml
b) 0.6-1.1 u/ml
c) 9.0-22.5 u/ml
d) 5.7-12.6 u/ml
e) 7.5-114.0 u/il
a) 7.0-17.2 ug/nl
b) 8.0-111.8 ug/mi
c) 8.6-13.2 ug/ml
d) 3.«-12.0 ug/i.1
IffilK 1 GEBEBJL INFORHJTIM | 8EFEEEKCE
1 1
I 1
1 !
a) 5.2 *or- 0.7 j/«u I a] cholecystic bile, cystic duct I Kiss, I.J.
b) 0.9 *or- 0.2 u/ml j open, 70-110 min, 6 cases j Farago, E.
c) 13.2 tor- 1.2 u/ml I b) cholecystic bile, cystic duct 1 Schnitzler, J.
d) 8.7 *oc- 1.3 u/aJ. 1 closed, 70-110 min, 1 cases | Varhelyi, I.
e) 10.9 *or- 1.1 u/ml | c) Choledochal bile, 70-110 min, 10 1 1981
I cases 1 International Journal
| d) Cholecystic bile, cystic duct I of Clinical
J open, 120-160 nin, 5 cases | Pharmacology, Therapy
| e) Choledochal bile, 120-160 min, 5 1 and Toxicology
| cases | 19(2):67-7a
| Samples taken during surgery I
1 higher than with similar dose of I
I aapicillin I
I i
I 22-69 yr old patients, »t 145-77 kg 1
1 1
1 ADULTS: INFECTIONS: BILE! BLOOD 1
J SFPUa; GALL BLADDER: LIVER; LtJ»SS; |
| ANTIBIOTICS; DFUS THEEAPY: DBOCS; 1
( CCMPABATIVE EVALUATIONS; SURGERY 1
!
! I
a) 11,7 +or- 1.0 | a) Lung operations, 60-110 mm i Kiss, I.J.
ucj/ail ; b) Lunq operations, 120-160 mm ) ?arago, B.
o) 10.7 +or- C.7 ; c) Biliary operations, 70-110 min ^ Schnitzler, 7.
ug/ml \ d) Biliary operations, 120-160 min I Varhelyi, £.
c} 11.1 «or- J.I , Times after t •;, in , ;931
bg/ml u Surgical samples international Journal
-'} 6.8 *or- 0.9 ,ig/ml : Serum^ 'ule, and tissue levels 2X ' cf clinical
i .'^her than with similar dose of ; Pharmacology, Therapy
! :- ' Llcll.'in ; a^d Tcxicolog /
! " ; i 9 (2) -.67-711
i 22-7" >; CJ,L ^dt^^^Sp 1 45-80 'xg i
1
S A?'TL!5^ l!S?':C?".C/3; Bli.E; BLOOt) !
', SEE01; G.-'ll, ELftLBES; LIVER; LONGS; i
1 ,\1?!3IO'-ICS • C^r.-l '•I'ES.-.PT; DRUGS; !
i CC^'-AFArivE 2 -.'I. li^rnIC«'SB Sf!RG£RY i
i f E
-------
-Thia-l-a-zabicyclo (3.2.0) heptane-2-carboxylic acid, 6-(2-amno-2- (p-hydroxjphenyll acetanido) -3,3-dinetiyl-7-oxo-, D- (8 CI)
-Thia- 1-azabicyclo (3. 2.0) heptane- 2-carboxylic acia, 6-( (aiiDO (
-------
l4,»'-Stilbenedioa. alpha,alpha'-diethyl-, (E)- (8 CI)
Phenol, l4,U'-<1,2-diethyl-1,2-etheneaiyl) bis-, (E)- (9 CI)
56-53-1
C18-H20-02
MW 268.34, «f 172 C
TISSUE
7538
Blood,
plasma
EXPOSURE 5001B
Ingestion
ISHTTICkL
METHOD
RIA
GC/NS
HOBBBB
OF C1SES
2
B»»GE
a) 1.2-2.4 ng/ol
b| O.H-1.5 ng/«l
c) 0.7-2.7 ng/al
ME4H
a) Not given
bj Not given
c) Not given
GENERAL INFORMATION
a) 1.5-2 hr after first of three 1 »g
doses/day
t) Secondary peaks at about 5-6 hr
c) 1.5-2 hr after second dose
Range of peaks, estimated froB graph
of 5 patients
Patients with cancer of the prostate
NEOPLASMS; BLOOD PLASMA; DRUG
THERAPY; DRUGS; HORMONES;
CHEBOTHERAPI; MEASUREMENT METHODS;
REFERENCE
Keip, H.A.
Read, G.F.
Riad-Fah«y, D.
Pike, A.W.
Gaskell, S.J.
Harper, M.S.
Griffiths, If.
1981
Cancer Research
»1:»693-»697
4,6(1H,5H)-pyriiidinedione, 5-ethyldihydro-5-phenyl-
125-33-7
C12-R14-S2-02
flu 218.25, HP 281-282 C
TISSUE
7539
Blood,
plasma
7540
Blood,
i serum
,
EXPOSURE FOOTE
Ingestion
Ingestion
ASA1YTIC&L
METHOD
GC
GC
HOHBER 1 BAHGE
OF CASES |
1
t | a) 96.5-0 mg/1
t b) 53-ta ttg/1
i
i
1
1
I
1
1
t
i
j
\
1
i
i
i
i
I
19 I a) 5.0-13.4 mg/1
I b) 3.3-34.6 mg/1
f c) 1.4-9.9 mg/1
| d) 1.4-11.2 mg/1
I O 2. ''-lit. 1 mg/1
t
(
BEAN | GENEBAL INFORM ATI ON
1
1
I
a) Not given | a) 90 min and 96 hr
b) Hot given \ b) 96 and 264 hr. Initial
| raeasurenent, 28.5 ag/1 at about 90
| mm. fletabolite (phenobarbital)
| Cverdose of 50 250-ng flysoline
I tablets and 100 100-sig Dilantin
I capsules.
1
| 26 yr old epilepsy patient
1
| Lethargic, atoxic and dysarthric in
1 Stage II coma. Bordei line
i intra ventricular conduction delay and
| a sinus tachycardia (1 10 beat pec
i nin).
1
I SUICIDE; BLOOD PLftSHA;
i
I
a) Not gi ec J a) Prunidoiie, 10 cases
bj Not gi en ( b) Phenobarbital, 10 cases
c) Not gx en [ c) Ptienyle*:hyl ma lonaoi.de, 10 cases
d) Not gi eu j d) Primi<3one, 9 cases
•;) Not gi er ) f) Phony lethylmaiOD ami df, 9 cases
j Steady state values aftt-: initial 250
; E q -1 O S 0 it i Cl ' r/ J S El y / fJ hi'
\ mail '"f-n ;* ' p , •<__-. 'T
1 lonot if rd ; -* >~~ , 5 \\ - c Tbinat ion
1 therauv wit.- >v i. -"- ? r' ' f T 1 optic
I IT uar» ' - t •
EEFEKENCE
Matzke, G.P.
Cloyd, J-C.
Sawchuk , R. J.
1981
Journal of Clinical
Pharmacology 21:92-99
Cloyd, J.c.
Miller, K. H.
Lcoptk , I- P. {
19B' (
and The tape Lit t cs
"2^ ' 3{ : 40^- 4 07 ;
f
:
-------
4,6 (IB, 5H)-pvri«i<3iiieaione. 5-ethyldihydro-5-phejiyl-
125-33-7
C12-H14-N2-02
«« 518. 25, HP 281-282 C
(CONTINUED)
TISSUE
7541
Blood,
serum
EXPOSURE RODIE
Ingestion
ANALYTICAL
METHOD
GC
NUMBER
OF CASES
1) 10
b) 9
B4NGE
a) 4.8-2.5 mg/1
b) 4.5-1.2 mg/1
flEAN ! GENERAL INFORMATION
1
1
a) Not given t a) 4 and 24 hr after 250 mg. Initial
b) Not given J measurement 2.6 ng/1 at 1 hr.
1 Mcnotherapy patient?
I t) 4 and 24 hr after 253 mg. Initial
] measurement 2.5 >g/l at 1 hr.
| combination therapy patients
1 Range of means, estimated from graph
1 17-69 yr old seizure patients
1
I ADULTS; CENTRAL NERVOUS SYSTEM
1 DISESSFS: BLOOD SERUM;
1 ABTICONVULSAHTS; DRUG THERAPY; DSUSS;
I COMPARATIVE EVALUATIONS; METABOLITES
1
REFERENCE
cloyd, J.C.
Miller, K.».
Leppik, I.E.
1981
Clinical Pharmacology
and Therapeutics
29(3) : 4 02-4 07
5-Oxa-1-azabicyclo (4.2.0) oct-2-ene-2-carboxylic acid, 7- ((carboxy (4-hydroxyphenyl) acetyl) anino) -7-methoxy-3- (£(1-methyl-l H-tetrazol-5- yl) thio) methyl) -8-oxo-
61552-97-2
C20-H20-N6-09-S
KS 520.52
TISSUE
7542
Blood,
serum
EZPOSOBE BOOTS
Injection
AHlirTICAL
METHOD
HPLC
1
NUMBER
OF CASES
14
_
RANGE
a) 195-29.5 ug/nl
L) 214-28.8 ug/ol
HEAN
a) Not given
b) Not given
GEBERAI. INFORMATION
a) 2 g dose
b) 3 g doss
Mean peak and trough steady state
concentrations (dose once every 8 hr)
Patients »ith bacterial infections
INFECTIONS; BLOOD SERUB; ANTIBIOTICS;
DRUG THERAPY; DRUGS; COMPARATIVE
EVALUATIONS
REFERENCE
Garzone, P.
Lyon, J.
Yu, V.L.
Zuravleff, J.
Diven, ».
Pasculle, V.
1981
Clinical Pharmacology
and Therapeutics
30 (1) : 86-94
.. .
-P-
c^
00
5-^hia-l-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3- ((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl) (metboxyimiuo)acetyl)aaino)-8-oxo -, (6R-trans)-
60846-21-1
C16-H17-N5-07-S2
TISSUE
7543
Blood,
serun
7544
cerebrosp
inal
fluid
EIPOSDRE ROUTE
Injection
ANALTTICAl
METHOD
Microbiological
Microbiological
NUMBER
OF CASES
12
12
BANGE |
a) 4-4S ug/ul
b) 3-9 ug/ml
c) 2.8-3 ug/ml
a) 3-19 ug/»l
b) 2-11 ug/«l
c) 1.8-14.3 ug/ml
d) 0.25-0.45 ug/»l
a) Not given
b) Not given
c) Not given
a) Not given
b) Not given
c) Hot given
d) Sot given
GENERAL INFORMATION
a) 1-2 hr
b) 3-4 hr
c) 5-5 hr
Dose 150-200 »g/kg/24 hr
Infants and children to 11 mo old
with bacterial meningitis.
CHILDREN: INFANTS; INFECTIONS;
CEBEBROSPIHAL FLOID; ANTIBIOTICS;
BBDG THERIPY; DRUGS
a) 1-2 hr
b) 3-4 hr
c) 4-5 hr
d) 5-6 hr
Dose 150 or 200
ig/kg/24 hr
Infants and children to 11 mo old
with bacterial meningitis.
CHILDBBH; INrjNTS; INFECTIONS;
CEBEBROSPINAI FLUID; ANTIBIOTICS;
DRUG THERAPY; DRUGS
Borderon, J.C.
Prieur, D.
Hoguet, B.
1981
La Nouvelle Press
Hedicale 10 (8) :580-584
Borderon, J.C.
Prieur, D.
Hoguet, B.
1981
La Mouvelle Press
Medicale 10(8) :580-584
-------
5-lhia-1-azabicyclo(».2. 0) oct-2-ene-2-carboiylic acid, 7 - (((2-(a linOBethyl) phenyl) acetyl) atino) -3-1 ((1- (carboxyaethyl) -1-H-tetrazol-5-yl) thiol methyl)-8-oxo-, (6R-trans)-
60925-61-3
C20-H21-N7-Q6-S2
B8 519.60
TISSUE
7545
Blood,
serum
7546
Urine
EXPOSURE ROUTE
Injection
Injection
AHALYTICAL
METHOD
Hicrobiological
Microbiological
NOB BEE
OF CASES
29
29
BJHGE
-
a) 14.7 tor- 3.0 - 51.5
+or- 3. 8 ugyml
b) 7.6 tor- 1.2 - 9.4
*or- 1.1 ug/Bl
c) 91.8 toe- 16.2 - 73.4
*or- 1 ug/Bl
d) 5.6 +or- 1.6 - 6.5
+or- 2.2 ug/ml
e) 33-56 ug/Bl
f) 22-64 ug/»l
266-3213 ug/»l
HEAN
a) Not given
b) Hot given
c) Mot given
d) Not given
e) 42.7 ug/Bi
f) 42.8 ug/ml
1315.8 *or- 347.7
ug/ml
GENERAL INFOBBATION
a) Mean peaks at end of infusion, day
1 and day 3 or 4. Dose, 30 lin IV of
500 «g, every 6 hr, 10 patients
b) Mean trough levels 6 hr after
infusion, day 1 and day 7 or 8. Dose
as in a)
c} Mean peaks at end of infusion, day
1 and day 7 or 8. Dose, 30 sin IV of
1 g, every 12 hr, 10 patients
d) Hean trough levels 12 hr after
infusion, day 7 or 8 and day 3 or U.
Dose as in c)
e) After 30 min IV of 500 mg (loading
dose) followed by continuous infusion
of 500 mg, 4 hr TVs. A.N. saaples on
day 3 or 4
f} Dose as in e) . A.n. sanples on day
7 or 8
MininUB inhibitory concentration for
either 500 mg, IV, every 6 hr, or 1
ga, IV, every 12 hr. Bo evidence of
drug cumulation.
Cancer patients, 17-71 yrs old, wt
42-120 kg
CARCINOHAS; SAECOBAS; BLOOD SEKUH;
ORINE; ANTIBIOTICS; DStlG THERAPY.;
DEOGS
6 hr after 1 g IV, over 30 ain.
23«-67* (mean 55«) of dose
Cancer patients, 17-71 yr old, wt
42-120 kg
CAPCINOIUS; SARCOHAS; BLOOD SEBOH;
UBIHE; ANTIBIOTICS; DEOG THERAPY;
DRUGS
BBFEBENCE
Estey, E. H.
Heaver, S.S.
LeBlanc, B.n.
Brovn. S.
Ho, D.H.
Bodey, G.P.
1961
Clinical Pharmacology
and Therapeutics
30 (3) : 398-403
Estey, E.H.
Heaver, S.S.
LeBlanc, B. H.
Brown, M.
Ho, D.H.
Bodey, G.P.
1981
Clinical Pharmacology
and Therapeutics
30(3) :398-403
5-Thia-l-azabicyclo (4. 2. 0) oct-2-ene-2-carboxylic acid, 7-((Uydroiyphenylaoetyl) amlno) -3- (((1-nethyl-1H-tetrazol-5-yl) thio) nethyl)-B-oio-, (6B- (6alpha, 7beta(B*)) )-
34444-01-4
C18-H18-U6-05-S2
HH 462.54
TissnE
Cerebrosp
inal
fluid
EXPOSURE BODTE
_
Injection
ANALYTICAL
BETHOD
»nnBEB
OF CASES
BABGE
b) 0.1-0.8 ug/ml
US&S
b) 0.28 ug/ml
GENERAL IKFOBHATIOK
ug/ml at 6 hr. Patients with
aeningeal inflammation
b) 2 and 2.5 hr. Final measurement
0.2 ug/Bl at 6 hr. Patients without
Keninqeal inflammation
Dose 100 mq/kg (1800-2500 mg/sq m
body surface)
Range of means
Newborn-14 yr old children
CHILDREN; CENTRAL NEEVOOS SYSTEM
DISEASES; INFECTIONS; CEREEROSPINAL
fLDID; AHTIBIOTICS; DRUG TBESAPY;
DRUGS
BEFEBENCE
Gahol, P.
Villanueva, R.
lonides, P.
1981
Drugs in Eiperiiental
Clinical Research
7(2) : 81-84
-------
cH-Oibenz (b,£)az€pine-5-carboxamide
398-46-4
Clf-H12-N2-0
tit 236.16, 8P 204-206 C
TISSUE
7548
Blood,
75H9
Blood,
EXEOSORE FOOTS
Ingestion
I n qes t io n
AHALYTICaL
METHOD
BPLC
BPLC
N0HB2B
OF CASES
35
1
BANGE
a) 1. 11-16.51 mg/1
b) 0.60-3.83 ag/1
a| 27-7 mg/1
b) «->1 mg/1
BEAN
a) Not given
b) Not given
a) Not given
b) Not given
GENERAL IHFOBBATION
a) Carbanazepine (C9Z)
t)
Carbamazepine-10, 11-epoiide (CB^EPOI) ,
letabolite
5. 1-212. 2» of C«Z present as C9ZEPOX.
Dose 0.3-2.0 g/day CflZ
Epileptic patients
AOSTRALIA; CENTRAL NERVOUS SYSTEH
DISEASES; BLOOD FLAS»A;
ABTICONVULSASIS; DROG TSEEAPT; DBOGSj
COBPABATIVE EVALUATIONS; HEASOREBENT
BETHODS
a) At admission to hospital and 166
hr later. 18 iig/1 at 2« hr and 27
nq/1 at about 36 hr
b) 36 and 120 hr after admission.
Initial neasureaent 3 ng/1.
about one day before admission
85 yr old
unresponsive to painful stinuli,
neurologically abnoraal
CAlirORBIA; NERVOOS SYSTEM DISEASES;
ELOOD PI ASIA; ANALGESICS;
ANTICOBVOLSANTS; DROG THESAPY; DEOGS;
BETABOLITES
REFERENCE
Bihaly, O.W.
Phillips, J.A.
Louis. S.J.
VajJa, ?.J.
1977
Clinical chemistry
23(12) :2283-2287
Bockoff, s.
Baselt. B.C.
1981
Clinical Toxicology
18(81:935-939
5H-Dibenz(b,f)azepine, 10,1l-dihydro-5-(3- (iethyla«ino)propyl)-, lODOhydrochloride (8 CI)
5B-Dibecz(b,f)azepine-5-propana»ine, 10.11-dihydro-»-«ethyl-, lonohydrochloride (9 CI)
58-28-6
C18-H22-N2.C1-H
B» 302.88, HP 211-218 C
7550
Blood,
plasma
EXPOSURE ROOTE
Ingestion
ANALYTICAL
HETHOD
NOBBEB
OF CASES
12
RANGE
a) 4.5-51.5 ng/il
b) 62-t07 ng/ml
a) Not given
b) Not given
GENEEAL INFORHAHON
a) 24 hr after 50 mg
b) steady state levels at 150 mg/day
Significant correlation betveen 24 hr
and steady state levels
22-41 yr old physically healthy
patients vith depressive symptoms.
BEHAVIOR DISOBDERS; BLOOD;
ASTIDEPRESSIVE AGENTS; DROG THERAPY;
DROSS
Rudorfer, S.V.
Young, R*c.
1980
Communications in
Psychopharmacology
4:185-188
-------
5H-Dibenz (b,f) azepine, 5-(3-(dimethylamino) propyl) - 10,11-dihydro- (8 CI)
5H-Dibenz(b,f)azepine-5-propanamine. 10. 11-dihydro-H,H-dimethyl- (9 CI)
•=0-49-7
C19-H24-H2
ne 280.uo, BP 160 c at o.oi mm Hg
TISSUE
7551
Blood
7552
Blood
7553
Blood
7554
Brain
7555
Pram
7556
liver
EXPOSURE ROUTE
ANALYTICAL
RETROD
GC
TLC
UV
GC/HS
Enzymatic
_
ac
oc
UV
GC
sc
uv
GC
NOflBEB
OF CASES
1
1
1
1
1
1
EAHGE
05. -1.0 mg/1
a) Hot applicable
b) Hot applicable
a) Hot applicable
b) Hot applicable
a) Hot applicable
b) Hot applicable
a) Hot applicable
b) Hot applicable
a) Hot applicable
b) Hot applicable
HEi«
Hot given
a) 0.05 «q*
b) 0.02 mgX
a) 0.02 »g/100g
b) 0.05 mg/lOOg
a) 0.5 mgH
b) 0.2 mgX
a) 0.3 ng/IGOq
b) 0.6 mg/lOOg
a) 1.2 mgS
b) 0.4 mgjf
GENERAL IHFORHATIOH
Dose probably sufficient to
contribute to signs and syaptois
Results fro* 4 laboratories receiving
identical samples foe toxic screen
Overdose drugs identified in 50f-70*
of cases
Laboratories agreed on 6 of 23 drugs
reported present in serui of 20
patients
imprecise.
probable drug overdose patients/
Boston, Ht
mSSACHOSETTS; BLOOD; AHULGESICS;
HBTIC08VD1SAHTS; iHTIDEPKESSIVE
AGCTTSj AHTIPYFETICS; DROG iBOSE;
DEOGS; HYPHOTICS; HAECOTICS;
SEDATIVES; TRAHflOILIZEES; COHPARATIVE
EVALOATIOHS; ALCOHOLS; BEASUREflEHT
HETHODS
a) XAD-2 resin extraction
HtlTOPSIES; BLOOD; BBMS-, KIDNEYS;
LIVES; DRUG ABUSE; DBOGS; TOEEHSIC
BEDICIHE; BEASOSEBEHT METHODS
a) Solvent extraction nethod
b) XAD-2 resin baq extraction method
Pcland
POLAHD; BLOOD; BRSIH; LIVER; DROG
JBUSE; DRUGS; BEASUKESEHT BETHODS
a) XAD-2 resin extraction
AUTOPSIES; BLOOD; BRAIH; KIDHEYS;
LIVER; DRUG ABUSE; DRUGS; ?OSEHSIC
BECICI1IE; BEASUREnEBT BETHODS
a) Solvent extraction aethod
b) X&D-2 resin baq extraction method
Fatal overdose case
Poland
POLAHD; BLOOD; BRAIN; LIVER; DRUG
ABUSE; DRIIGS; H E A SU RE « E8T HETHOOS
Fatal poisoning
LIVER; DRUG ABUSE; DRUGS; FOREHSIC
MEDICINE; nEASUREHEDT METHODS
REFER EH CE
Ingelfinger, J.&.
Isakson, G.
Shine, D.
Costello, C.E.
Goldman, P.
1981
Clinical Pharmacology
and Therapeutics
29(5) :570-575
Bogusz, M.
sierz, J.
Bialka, J.
1978a
Archives of Toxicology
41: 153-162
Bogusz, n.
Gierz, J.
1978b
Forensic Science
International 12:73-82
Bogusz, n.
Gierz, J.
Bialka, J.
1978a
Archives of Toxicology
41:153-162
Bogusz, H.
Gierz, J.
Bialka, J.
1978b
Forensic Science
International 12:73-82
Bogusz, B.
Gierz, J.
Bialka, J.
1978a
41:153-162
.c-
-g
(NEXT PAGE)
-------
5fl-Dibenz
-------
5H-Dibenzo(a,d) cycloheptene-delta(5,gamaa)-propylamiae, 10.11-dihydro-8,N-diaethyl- (8 CD
1-Propanaaine, 3- (10,11-dihydro-5H-dibenzo(a,d) cyclohepten-5-ylldene) -H,N-dimethyl- (9 CI)
50-48-6
C20-H23-N
MS 277.39, HP Hydrochloride 196-197 C
(CONTINUED)
Tissue
7561
Eiooa
7562
Eiooa,
plasna
7563
Blood,
plasma
EXPOSURE ROUTE
Ingestion
Ingestion
RHALYTICAL
METHOD
GC
GC
NDflBEB
OF CASES
7
6
6
B4NGB
0.04-0.73 »g/100 ml
._ ..
a) 5.0-33 ag/ml
S) 1*4-39 ng/»l
C) 0.9-3.3 ng/ml
d) 2.1-il.a ng/ml
e) 4.5-14 ng/ml
f) 1.3-6.4 ng/ml
g) 5.5-66 ng/al
b) 36-75 ng/ml
i) 1.8-9.5 ng/«l
IV 1.0-9 ng/ml
*) a-25 ng/nl
1) 3.4-19 ng/«l
a) 15-73 ng/il
b) 1.5-9.2 ng/ml
C) 5.6-28 ng/ml
d) 4.4-15 ng/al
DEAN
Not given
a) Hot gi e
b) not gi e
c) Not gi e
d) Not gi e
e) Not gji e
f) Sot gi e
g) Not gi e
h) Not gi e
i) Not gi e
j) sot gi e
h) Not gi en
1) Sot gi en
a) Sot given
b) Not given
c) sot given
d) Not given
GESEEHL ISFOBBSTION
Drag induced fatalities. Ethanol (2
cases, 0.02-0.15 g/100 «1) ,
desipraaine (1 case, 0.03 ng/100 •!) ,
thioridazine (2 cases, 0.07-0.18
ng/100 nl) f methadone f2 cases, 0.03
ng/100 ml), and carisoprodol (1 case.
0.2 ng/100 al) also found.
Sutopsies, 1975-76, Los Angeles
County, CA
CJ1IFOBNU; AUTOPSIES; CASE
HISTORIES; BLOOD; DRUG AB0SB; DBUGS;
FORENSIC HEDICISE; 1LCOHOLS
a) Initial •easurenents at 2 hr after
50 ug
b) Peak valaes at 3-« he after 50 ng
c) Final measureaents at 72 hr after
50 og
3) Betabolite (nortriptyline) .
Initial neasurenents at 2-3 hr after
50 rag
e) Metabolite (nortriptyline). pea*
valoes at lj-24 hr after 50 ng
f) Metabolite (nortriptyline). Final
•easurements at 72 hr after 50 ng .
g) Initial aeasurenents at 1-2 hr
after 100 mg
h) peaX values at 2-(| hr after 100 Big
i) Final neasureaents at «8-72 hr
100 mg
k) metabolite (nortriptyline). Peak
valoes at 1-12 hr after 100 ag
1) Metabolite (nortriptylina) . Final
measurements at 18-72 hr after 100 ng
Healthy volunteers < 40 yr old
ADOLTS; BLOOD PL1SM; ASTIDEPEESSI VE
BGISTS; DRUGS; BI1SBOLITES
a) Peak levels at 4-12 hr. Initial
measurements 1.0-19 ng/ml at 1-3 hr
b) Final measurements for a) at 48-72
hr
c) Peak levels at 8-48 hr.
Nortriptyline (metabolite) . Initial
measurements 1.5-7.7 ng/nl at 3-8 hr
d) Final neasureaents for c) at 48-72
hr
Dose, 100 mg sustained release tablet
BIOOD PIASBi; ANTIDEPRESSI VB AGENTS;
DROGS; METABOLITES; UNITED KINGDOM
DEFERENCE
Nakamura, 5.R.
Soguchi. T.T.
Griesemer, E.C.
1979
Journal of Analytical
Toxicology 3:137-142
Burch, J.E.
Hullin, B.P.
1981a
Psychopharmacology
74:35-42
Burch, J.E.
Hullin, E.P.
1981b
Psycho pharmacology
74:43-50
(NEXT PAGE)
-------
5H-Dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine, 10,11-dihydro-H,N-di«ethyl- [8 CI)
1-Propanamine, 3-(10,1l-dihydro-5R-dibenzo (a,d)cyclohepten-5-yliden9)-S,H-dimethyl- (9 CI)
50-18-6
C20-H23-N
BB 277.39, HP Hydrochloride 196-197 C
(CONTINUED)
TISSUE
7561
Elood,
plasma
7565
"Brain
7566
Cerebrosp
inal
fluid
7567
Heart
1
(
EXPOSURE BOUTE
Ingestion
Ingest ion
Inqestion
Ingestion
A HA L IT 1C A L
METHOD
GC
GC
GC
TLC
Km see
OF CASES
1
1
1
32
EA8SE
.
a) 1070-360 ng/ul
i)| 350-150 tig/ml
c) Hot applicable
d) Not applicable
a) 6.1-8.5 ug/g
b) 18.6-25.8 ug/g
a) Hat applicable
b) Not applicable
a) 0.09-18.10 ag/g
b) lot detected-10.02
ug/g
(BEIT
BEAN
a) Hot given
b) Mot given
c) 0.25 ug/al
d) 0.58 ug/ml
a) Not given
b) Not given
a) 0.55 ug/ml
b) 1.10 ug/ml
al 11.29 toe- 16.25
ug/g
b) 6.11 *or- 9.12
ug/g
PAGE)
GENERAL INFOBMATtON
a) Estimated 10 and 30 hr after
overdose. 110 ng/ml at 12 hr
b) Estimated 15 and 30 hr after
overdose. 100 ng/nl at 12 hr.
Metabolite (nortriptyline)
c) Autopsy sanple (death about 15 hr
after overdose)
d) Autopsy sample. Metabolite
(nortriptyline)
Estimated fron graph
Cose and tiie of ingestion not known.
33 yr old suicide victim
Elevated pulse and blood pressure,
sinus tachycardia, coma,
cardiopulBOnary arrest.
ADULTS; AUTOPSIES; SUICIDE; BILE;
BIOOD PLASMA; BBAIN; CEBEBBOSPISAL
FLUID; HEABT; KIDNEYS; LIVBB;
PITUITASI GLAND; VITBEOOS HUflOB;
SIBINAL VESICLES; ANTIDEPRESSIVE
AGENTS; DEOG ABUSE; DBUGS
a) Aiitriptyline
b) Metabolite (ncrtriptyline)
Autopsy saaples, dose unknown. Bange
for different areas of brain
33 yr old suicide victim
Elevated pulse and blood pressure,
sinus tachycardia, coma,
cardiopulmonary arrest.
ADOTTS; AUTOPSIES; SUICIDE; BILE;
BLOOD PLAStU; BRAIN; CEBEBBOSPINAL
FLUID; HEABT; KIDNEYS; LIVER;
PITUITARY GLAND; VITBEOOS HUHOB;
SEHISiL VESICLES: A»TIDEPRESSIVE
AGENTS; DRUG ABUSE; DRUGS
a) Amitriptyline
b) Metabolite (nortriptyline)
Autopsy sanples. Dose unknown
33 yr old suicide victim
Elevated pulse and blood pressure,
sinus tachycardia, coma,
cardiopulmonary arrest.
ADULTS; AUTOPSIES; SUICIDE; BILE;
BLOOD PLASMA; BE1IH; CEBBBBOSPIDAL
PIUID; HEART; KIDKBYS; LITER;
PITUITARY GLAND; VITREOUS HUHOR;
SEMINAL VESICLES; ANTIDEPRESSIVE
AGZHTS; DROG ABUSE; DBUSS
a) Parent compound
b) Metabolite (nortriptvline)
Suicide victims, San Diego, CA
AUTOPSIES; SUICIDE; BLOOD; HEART;
IIVER; ANTIDEPRESSIVE AGEHTS; DRUG
ABUSE; DRUGS; FORENSIC MEDICINE
Hurst, H.E.
Jarboe, C.H.
1981
Clinical Toxicology
18(1) :119-125
Hurst, H.E.
Jarboe, C.H.
1981
Clinical Toxicology
18(1) : 1 19-125
Hurst, H.E.
Jarboe, C.H.
1981
Clinical Toxicology
Bailey, D.S.
Shaw, s.f.
1980
Journal of Analytical
Toxicology 1:232-136
-------
5H-Dlbenzo(a,d) cycloheptene-delta(5,ga«»a|-propylaaine, 10. 11-dinvdro-B,N-di«etliyl- (8 CI)
1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepte«-5-ylidene)-N,N-di»ethyl- (9 CI)
50-148-6
C20-H23-N
tit 277.39, HP Hydrochloride 196-197 C
(CONTINUED)
TISSUE
7568
Heart
7569
Kidney
7570
liver
7571
liver
EXPOSURE BODTE
I ngestion
Ingestion
Ingestion
Ingestion
ANALYTICAL
METHOD
GC
GC
TLC
GC
HOB BEE
or CASES
1
1
32
1
BINGE
a) Hot applicable
b) Hot applicable
a) Hot applicable
b) Nat applicable
.
a) 0. 15-243.00 ug/g
b) Not detected-156.00
ug/g
a) Not applicable
b) Not applicable
HEAN
a) 2.7 ug/g
b) 9-6 ug/g
a) 2.9 ug/g
b) 8.2 og/g
a) 62.21 »or- 71.47
ug/g
b) 141.93 *or- 89.28
ug/g
a) 1,7 ug/g
b) 3,0 ug/g
GENEBAL INFORMATION
a) Amitriptyline
b) netabolite (nortriptyline)
33 yr old suicide victim
Elevated pulse and blood pressure,
sinus tachycardia, coma,
cardicpulnonary arrest.
ADULTS: AUTOPSIES; SUICIDE; BILE;
BLOOD PLASMA; BRAIN; CEREBBOSPINAL
FLUID; HEART; KIDNEYS; LIVEB;
fITOITARY G1AND; VIIEEOUS ROBOE;
IHTIDEPRESSIVB AGENTS; DRUG IBOSE;
DBUGS; SEMINAL VESICLES
a) Aaitriptyline
t) Betabolite (ncrtriptyline)
Autopsy sanples. Dose unknown
33 yr old suicide 7icti«
Elerated pulse and blood pressure,
sinus tachycardia, cona.
AOOLTS; AUTOPSIES; SDICIDS; BILE;
BLOOD PLASBA; BRAIN: CEREBSCSPlNAL
FLUID; HE1RT; KIDNEYS; LIVER;
FITDITAET GLAND; VITREOUS HUnOR;
ANTIDEPRESSIVE AGENTS; DRUG ABUSE;
tRUGS; SEMINAL VESICLES
a) Parent compound
t) netabolite (ncrtriptyline)
Suicide victims, San Diego, CA
AUTOPSIES; SUICIDE; BLOOD; HEART;
LIVER; ANTIDEPRBSSIVE AGENTS; DRUG
ABUSE: DRUGS; FOEESSIC BEDICINE
a) Anitriptyline
b) Betabolite (nortriptyline)
Autopsy samples. Dose unknown
33 yr old suicide victim
Elevated pulse and blood pressure,
sinus tachycardia, coma,
cardiopulmonary arrest.
ADULTS; AUTOPSIES; SUICIDE; BILE;
BLOOD PLASBA; BRAIN; CEREBROSPINAL
FLUID; HEARI; KIDNEYS; LIVES;
EITuTTARY SLASD; VITREOUS HOBOR ;
ANTIDEPPBSSIVZ AGENTS; DRUG ABDSE;
[BUGS; SEMINAL VESICLES
REFERENCE
Hurst, H.E.
Jarboe, C.H.
Clinical Toxicology
18(1) :119-125
Hurst, H.E.
Jarboe, C.H.
1981
Clinical Toxicology
18 (1) : 1 19-125
Bailey, D.S.
Shaw, R.F.
1980
Journal of Analytical
Toxicology 1: 232-236
Hurst, H.E.
Jarboe, C.H.
1981
Clinical Toxicology
18(1): 119-125
(NEXT PAGE)
Oi
-------
?H-Dibenzo(a,d) cycloheptene-delta (5,gama) -propylamine, 10, 1 1-dihydro-B.B-dimethyl- (8 CI)
1-Propananine, 3- (10, T 1-aihydro-5K-dibemo(a,di cyclohepten-5-yLidene) -N(N-di.methyl- (9 CI)
5C-18-6
C20-B23-H
HW 277.39, HP Hydrochloride 196-197 c
(CONTINUED)
TISSUE
7572
Pituitary
7573
Seminal
vesicle
7511*
Vitreous
huaor
EXPOSOEE HODTE
iDgestioo
Ingest ion
Inqestion
AWALYTIC&L
HETHOD
GC
GC
GC
-..-
BOBBER
or CASES
1
1
1
BANGE
a) Not applicable
bj Hot applicable
a) Hot applicable
b) Sat applicable
a) Sat applicable
b) Hat applicable
BEAN
a) 3.8 ug/g
b) 13.8 ug/g
a) 3.8 ug/g
b) l.li ug/g
a) 0.05 ug/»l
b) 0.06 ug/ml
GEBERAL IHFOBB1TI08
a) Unitriptyline
t) Hetabolite (ncrtriptyline)
iutopsy sabples. Dose unknown
33 yr old suicide victi«
Elevated pulse and blood pressure,
sinas tachycardia, coma,
cardiopulBOnacy arrest.
JCOITS; AUTOPSIES; SniCIDE; BILE;
BLOOD PLASBA; BR»IS ; CEBEBEOSPIHAL
FLOID; HEART: KIDSEYS; LIVEB;
FITOITAPy GLABD; VITHEOHS HIJNOB;
SEHIBAl VESICLES: A11TI DEPEESSHZ
JGENTS; DStlG ABUSE: DBOGS
a) Amitriptyline
t) netabolite (nortriptyline)
Autopsy saaples. Dose unknown
33 yr old suicide victim
Elevated pulse and blood pressure,
sinus tachycardia, coma,
cardiopulmonary arrest:.
ACOLTS; AUTOPSIES; SOTCIDE; BItE;
BLOOD PLASflJ; BBdIN; C EBEBECSPIHAL
fLOID; HEAKT; KIDBETS; LIVER;
PITOITAEY GLABD; VITSEOHS HUHOB;
AHTIDEPBESSIVE AGEKTS; DSUG JBOSB;
EROGS; SEH1HAL VESICLES
a) ABitriptyline
b) Metabolite (nortriptyline)
Autopsy sacples. Dose unkDovn
33 yr old suicide v let in
Elevated pulse and blood pressure,
sinus tachycardia, coma,
cardicpulftonary arrest.
ADOLTS; AOTOPSIES; SOICIDE; BILE;
BLCOD PLASNA; BRAIN; CEGEBROSPIBtL
FLDID; HEART; KIDNEYS; LIVER:
PITUITARY GLAND; VITREOOS HOBOB ;
SEHIHAL VESICLES: ANTIDEPRESSIVE
AGENTS; DRUG ABUSE; DRUGS
REFERENCE
Hurst, H.E.
Jarboe, C. H,
1981
Clinical Toxicology
18(1) :119-125
Burst, H.E.
Jarboe, C.H.
1981
Clinical Toxicology
18 (1) :1 19-125
Hurst, H.E.
Jarboe, C.S.
1961
18(1): 119-125
-------
6,1«-Ethenoiorphinan-7-iiethanol, 17- (cyclopropylnethyl)-alpha- (I, 1-dimethylethyl)-1,5-epoiy-18, 19-dihydro-3-nydro I y-6-«etho*y-alpha-«einyl-, (Salpha,7alpha(S) | -
52185-79-7
C29-Hil1-N-0<4
BS U67.71
TTSSdE
7575
EXPOSURE ROUTE
Injection
18HLTTICM.
BETHOD
RIA
NOB BSE
OF CASES
214
BADGE
-
a) 18.62-0.37 ng/ml
b) 11. 62-0. 38 ag/al
c) 3.61-0.36 ng/ml
HEAH
a) Not given
b) Sot given
c) Not given
GENERAL IHFOBHATION
a) 2 and 180 Bin after 0.3 log,
intraoperatively, IV
b) 2 and 130 Bin after 0.3 >g.
postoperatively, IV, given 180 iin
after the initial intraoperative dose
(10 subjects)
c) 5 and 130 min after 0.3 mg.
postoperatively IM, given 180 Bin
after initial intraoperative dose (11
subjects). Initial measurement 3.56
ng/ol at 2 min.
Hospital patients undergoing total
hip rep lace aent surgery.
ELOOD PIASHA; ANALGESICS; DROG
THERAPY; DBflGS; SiSCOTICS; SDBGEBT
BEFEBEHCE
BullinghaB, R. E. S.
HcQuay, H.J.
Hooce, A.
Bennett, H.B. D.
1980
Clinical Pharmacology
and Th e ra pe ut i cs
26 (5): 667-672
6H-Dibenzo (b.d) pjran-1-ol, 6a,7,8, 10a-tetrahydro-6,6-9-trimatiiYl-3-pantyl-,
1972-08-3
C21-H30-02
B» 31H.U5
TISSUE
7576
Blood,
plasma
EXPOSURE ROUTE
Inlection
Ingestion
Inhalation
ANALYTICAL
HETHOD
GC/BS
SUB BEE
OF CASES
11
BADGE
.
a) 220-1 ng/ml
b) 80-2 ng/ml
c) 6-1.5 ng/ml
a) Not given
b) Not given
c) Not given
GENERAL INFORBATIOH
.
a) 3 and 2HO nin after 5 Bg I»
b) 3 and 210 min after 19 ig
cigarette
c) 60 and 360 min after 20 mg oral.
Initial measurement 3 ng/ml at 30 min
Relationship to degree of
Range of means, estimated from graph
18-35 yr old volunteers
pulse rate
ADULTS; BLOOD PLSSHA ; DRTCS:
PSYCHCTROPIC DRUGS; COBPAEATIVE
EVALUATIONS
REFERENCE
Hollister, L.E.
Gillespie, H.K.
Ohlsson, A.
Lindgren* J.E.
Hahlen, A.
Agnrell, S.
Journal of Clinical
Pharmacology
21:1713-1773
(NEXT PAGE)
-------
6H-Dibenzo(b,d) pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6-9-triBethyl-3-pentyl~, {6aB-trans)-
1972-08-3
CJ1-B30-02
B8 311.15
(COHTIHUED)
TISSUE
7577
Blood,
plasma
7578
plasma
Blood,
plasma
7580
Blood,
plasma
EJtPOSOBE BOOTE
Injection
Ingestion
Inhalation
Inhalation
Inhalation
ANALYTICAL
METHOD
GC/BS
TLC
GC/BS
.
EIA
-
SOBBEB
OF CASES
11
_
EANGE
a) 0.8-9.3 ng/ml
b) 1.0-8.8 ng/ml
c) 0.2-62 ng/ml
d) 0. 1-3.1 ng/ml
e) 2.0-0.025% of dose
f) 0.12-0* of dose
37.5-1.9 ng/nl
b) 100-0.25 ng/ml
-
a) I7S-0 ng/ml
b) 180-20 ng/ml
MEAN
a) Not given
b) Not given
c) Not given
d) Not given
e) Not given
f) Not given
Not given
b) Not given
a) sot given
b) Hot given
GENERAL IHFORBATION
a) 15 and 360 lain after 20 mg oral.
Final neasurement 1.3 ng/ml at 1110
•in (6 subjects)
b) 15 and 360 min after 20 mg oral.
Metabolite, 1 1-hydroxy-3elta-9
tetrahydrocannabinol (11-OH-THC) .
• in. Other metabolites totaled 128
ng/Bl (same subjects as a) )
c) Initial level and 20 min after 25
Bin IV of 1-5 »g. 2.1 ng/Bl at 1320
min (7 subjects)
d) Initial level and 25 min after 25
min IV of »-5 mg. 0.2 ng/ml at 1320
in. Hetabolite (11-OH-THC). Other
metabolites totaled about 17 ng/ml at
20 sin (sane subjects as c))
e) ^ and 1U1Q Bin after 6.8 mg, from
smoking
f) 20 and 1110 min after 6.8 mg, from
smoking. Betabolite (11-OH-THC).
Other metabolites acocunted for 2-1*
of dose
from graph.
ELOOD PLASBA; DEINE; DBOGS;
PSYCHOTEOPIC DBOGS; INHALATION:
BETABOLISH; BBTABOLITES
0.25 and 21 hr after SBOking
Initial aeasureaent 3.8 ng/Bl
fiange of means
Healthy 21-26 yr olds
B100D PLASBA; DEOGS; PSYCHOTEOPIC
oral dose, and following 2 Bin IT of
2 mg
b) At 5 and 1600 min after chronic
oral dose (20 or 30 mg every 1 hr for
12 days) and following 2 min IT of 2
mg
Estimated from graph
Healthy 22-30 yr olds, »t 66.2-83.7
cigarettes per week for 5.8 yr
(average)
ADULTS; BLOOD PLASHA; DEINE; DBOGS;
PSICHOTEOPIC D8DGS
a) 0.25 and 1 hr after 3 consecutive
marihuana cigarettes
b) 0.25 and 18 hr. Same study as a).
Pre-intoxication level approxiaately
50 ng/ml. Hetabolite
( 11-nor-9-carboxy-delta-9
tetra-hydrocannabinol
Estiaated froa graph
BLOOD PlASflA; SALIVA; DRUGS;
PSICHOTEOPIC DBOGS; HEASOREBEBT
HETHODS
BEFERBNCE
«all, M.E.
Perez-Reyes, B.
1981
Journal of Clinical
pharmacology
21:1785-1895
valentine, J.L.
sutshall, P.L.
Gano, H.B.
Lovegreen, P.D.
Thompson, E.D.
Niu, B.C.
1977
Pharmaceutical sciences
66(1): 1263-1266
Jones, Et.T.
1980
Journal of Pharmacology
and Experimental
Therapeutics
215(1) :35-11
Gross, S.J.
Soares, J.E.
1978
Journal of Analytical
Toxicology 2:98-100
1
(HEIT PAGE)
CO
-------
6H-Dibenzo(b,d) pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6-9-trimethyl-3-pentyl-, (6aR-trans)-
1972-08-3
C21-H30-02
B8 31H.4S
(COHTIH3ED)
TISSDE
T581
Saliva
7582
arine
7583
Urine
EXPOSOBE BOOTE
Injection
Injection
Ingestion
ANALYTICAL
BETHOD
BIA
GC/MS
TLC
HPLC
NOHBEB
OF CASES
7
6
BANGE
a) 90-35 ng/ml
b) 67-25 ng/ml
a) 5-1.2% of dose
b) 3.5-0.7% of dose
c) 1.5-0.5% of dose
a) Not given
b) Not given
BEAN
a) Hot given
b) Hot given
a) Hot given
b) Hot given
c) Not given
a) 23.2 »or- 1.2%
b) 17.5 *or- 3.3%
GENERAL IHFOBHATION
a) 0.25 and 4.5 hr after 3 marijuana
b) 0.25 and 3.5 hr. Same study as a)
Hetabolite (ll-nor-9-carboxy-delta-9
tetrahydrocannabinol)
BLCOD PLASBA; SALIVA: DBOGS;
PSYCHOTBOPIC DBOGS; 1EASOBES.ENT
METHODS
a) Total cannabinoids
b) Conjugated cannabinoids
c) Free cannabinoids
20 and 72 hr after 1-5 mg IV
B100D PLASBA; OBINE; DBOGS:
PSYCHOTtOPIC DBOGS: INHALATION;
METABOLISM; METABOLITES
a) 96 hr output, before chronic oral
dose and following 2 min IV of 2 mg
b) After chronic oral dose (20 or 30
ag every 4 hr for 12 days) and
following 2 min IV of 2 »g
Healthy 22-30 yr olds. «t 66.2-83.7
kg. Smoked 11-40 marijuana
cigarettes per week for 5.8 yr
(average)
IDCLTS; BLOOD PUSH*; OBXHI; BEDGS;
PSYCHCTBOPIC DROGS
BEFEBENCI
Gross. S.J.
Soares. J.B.
1978
Journal of Analytical
Toxicology 2:98-100
Rail. M.E.
Perez-Reyes, n.
1981
Journal of clinical
Pharmacology
21: 1785-1895
Runt, C.A.
Jones, B.T.
1980
Journal of Pharmacology
and Experimental
Therapeutics
215(1) : 35-44
7H-Furo(3,2-g)(1)benzopyran-7-one, tt-nethoiy-
181-20-8
CI2-H8-01
B8 216. 18
TISSUE
7581
Blood,
serun
7585
Orine
EXPOSOBE BOOTE
Ingestion
Ingestion
AHALYTICAL
BETHOD
HPLC
HPLC
TLC
NOBBEB
OF CASES
a) 'I
b) 3
5
EANGE
a) 257-530 ug/1
b) 61-152 ug/1
2.0-8.6 ug/2U hr
HEAH
a) 406 *or- 103 ug/1
b) 92 «or- 52 ug/1
5.7 »or- 2.5 ug/2t hr
GEHEB»L INFOBBATTOH
a) 2.5-1 hr (mean 3.2 hr) after 1.2
«g/kg
b) 2.5-3 hr («ean 2.8 hr) after 0.6
Peak level
Psoriasis patients, 21-69 yr old, wt
61-93 kg
ADtlLTS; SKIN DISEASES; BLOOD SEBtJH ;
OBIHE; DBtJG THEBAPY; DBDGS
Dose 1.2 og/kg. Not detected in 2
patients.
Psoriasis patients, 21-69 yr old, wt
61-93 kg
AD01TS; SKIS DISEASES; BLOOD SEBOil;
HEINE; DBOG THEBJPY; DBDGS
BEFEB5NCE
Stolk, L.H.L.
Kesterhof, v.
Cormane, B.H.
1981
British Journal of
Dermatology 105:115-420
Stolk, L.fl.L.
Wester hot, H.
Cormane, B.H.
Van Zvieten, P. A.
1981
Dermatology 105:415-420
-------
9H-Dibenzo(b,di pyran-9-one, 3-(
51022-71-0
, 1-diieth;lheptyl.)~G.6a, l,S. 10, 10a-a8Xdhy4i:o-5-iiydroxy-6,&-dimethyl-, trans- (<•-)-
TISSUE
7586
Blood,
plasma
7587
Urine
EXPOSURE ROOTE
I n jec tion
Ingestion
I n *1 ec t io n
Ingestion
ABALYTICAL
HETHOD
TLC
Radi.onet.ry
TLC
Badionetry
HOHBEB
OF CASES
8
8
BAHGE
a) 40-0.3 ng Eq/ml
b) 25-0.55 ng Eq/al
c) 1.8-0.7 ng Eq/mi
a> t.3-12 ng Sq/ml
e) 0.7-1.7 ng Eg/ml
£) 0. 13-1.2 ng Eg/ml
a) Hot given
b) Hot given
HEAD
_
a) Hot given
b) Hot given
CJ Not given
d) Hot given
e) Hot given
f) Hot given
a) 22* of dose
b) 24% of dose
GESE8SL IHFOEII1LTIO!!
a) Total radioactivity. 0 and 72 hr
(5 sub-jects)
b) Habilone. 0 and 8 hr (2 snb-Jects)
c) Alcohol netabolite of nabilone. 0
and 4 hr (3 subjects)
d) Total radioactivity. Initial
•easarenent and U hr. 1.4 ng Eq/al
at 72 hr (2 subjects)
e) Habilone. 1 and 8 hr. Initial
•easurement 0.7 ng Eq/sl (2 subjects)
f) Alcohol aetabolite of nabilone.
Bq/il at 8 hr (2 subjects)
Pange of neans, estimated from graph.
after 0.5 «q (12 uci) IT (a)-cH or
2.0 ng (48 uci) oral (d)-f)).
Healthy 23-13 yr olds
BLOOD PLASH1; DBIHE; DRUSS;
PSTCHOTEOPIC DEHB5; HETABOIITES
a) 7 day cumulative excretion after
0.5 ng (12 uci) 17 (5 subjects)
b) Cumulative excretion after 2.0 ag
(48 uci) oral (2 subjects)
Bealthy 23-43 yr olds
E1COD PLASBA; "JSIHEj DEUGS ;
PSTCHOTFOPIC DRDGS; »ETABOLI1ES
KEFEB
Bubin, A.
Lenberger, L
Darrick, P.
Crabtree, P..
Sullivan, H.
Roue , H .
oberaeyer, B
1977
Clinical Pha
and Therapeu
22(1):85-91
Rubin, A.
Lemberger, L
Warrick, P.
Crabtree, B.
Sullivan, H.
Bowe, H.
Obermeyer* B
1977
Clinical Phat
and Therapeut
22(1) :85-91
00
O
-------
481
J0272 -1
REPORT DOCUMENTATION
PAGE
I. REPORT NO
EPA 560/5-82-003 A and B
[2.EIS-163/V5/
Pi and P2
«. Title and Subtitle
Chemicals Identified in Human Biological Media, A Data Base,
Fourth Annual Report, October 1982
3 Rec.pienfs Accession No
5 Report Date
7. Author^) M. Virginia Cone, Margaret F. Baldauf,
Dennis M. Opresko, and Mary S. Uziel
8. Performing Organization Rept. No
9. Performing Organization Name and Address
Chemical Effects Information Center
Information Center Complex/Information Division
Oak Ridge National Laboratory
Oak Ridge, Tennessee 37830
JO. Proiect/Task/Work Unit No.
11. Contract(C) or Grant(G) No
EPA TAG No. 78-D-X383
(G)
12. Sponsoring Organization Name and Address
U.S. Environmental Protection Agency
Office of Toxic Substances
Exposure Evaluation Division (TS-798)
Washington, D.C. 20460
13. Type of Report 8, Period Covered
Annual Report 9/81-9/82
15. Supplementary Notes
16. Abstract (Limit- 200 words)
A comprehensive data base of chemicals identified in human biological media (tissues
and body fluids) has been established under the direction of the Environmental Protection
Agency's Office of Toxic Substances Exposure Evaluation Division. This centralized resource
of body-burden information was inspired by the concern of government scientists over
continuing reports of toxic chemicals in human tissues and body fluids.
Body burden is a reflection of exposures to food, air, and water contaminants,
as well as Pharmaceuticals. The systematic acquisition of body-burden data will facil-
itate a more relevant assessment of human exposure to toxic chemicals and xenobiotics
than was previously possible using environmental contamination levels.
Data were obtained primarily from the open literature through manual searches of
selected journals. Retrospective searching to 1974 is complete and has yielded about 4400
pertinent documents of which approximately 2380 have been entered into the data base as of
this report. These sources identify over 1000 chemicals that have been found in human
biological media.
17. Document Analysis a. Descriptors
Body burden
Human tissues/body fluids
Residues
b. Identifier^/Ooen-Ended Terms
c CCSATI Fx^/C--
IS. Availability Statement
RELEASE TO PUBLIC
19. Security Class (This Report)
UNCLASSIFIED
20. Security Class (This Page)
UNCIASSIFIED
21. No of Pages
858
22. Price
(See ANSI-Z39 IS)
See Instructions on Reverse
OPTIONAL FORM 272 (4-77)
(Formerly NTIS-35)
OpDartment of commerce
-------
483
EPA 560/5-82-003B
ORNL/EIS-163/V5-P2
INTERNAL DISTRIBUTION
1. S. I. Auerbach
2. M. F. Baldauf
3. M. V. Cone
4. J. T. Ensminger
5. W. Fulkerson
6. H. B. Gerstner
7. D. M. Opresko
8. C. R. Richmond
9. G. D. Robbins
10. M. S. Uziel
11. Biology Library
12-13. Central Research Library
14. Document Reference Section
15. ICC Publications Office, 2001
16-25. ICC Resource Center, 2001
26-27. Laboratory Records
28. Laboratory Records, RC
29. ORNL Patent Office
EXTERNAL DISTRIBUTION
30. Executive Director, Oak Ridge Associated Universities,
P.O. Box 117, Oak Ridge, Tennessee 37830.
31. Office of Assistant Manager, Energy Research and Development,
Department of Energy, Oak Ridge Operations Office, Oak Ridge,
Tennessee.
32-58. Technical Information Center, Department of Energy, Oak Ridge,
Tennessee 37830.
U S GOVERNMENT PRINTING OFFICE 1983-646055/266
------- |