AIR QUALITY CRITERIA
P ARTICULATE MATTER
   U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE
                  Public Health Service
         Consumer Protection and Environmental Health Service

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                                    450R69101
          AIR QUALITY CRITERIA

                      FOR
           PARTICULATE  MATTER
U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE
                Public Health Service
    Consumer Protection and Environmental Health Service
            National Air Pollution Control Administration
                    Washington, D.C.
                     January 1969

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National Air Pollution Control Administration  Publication No. AP—49

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                                       Preface
  Air quality criteria tell us what science has
thus far been able to measure of the obvious
as well as the insidious effects of air pollu-
tion on man and his environment. Such cri-
teria provide the most realistic basis that we
presently have for determining to what point
the levels of pollution must be reduced if we
are to protect the public health and welfare.
  The criteria that we can issue at the pres-
ent time do not tell us all that we would like
to know.  If all of man's previous experience
in  evaluating1  environmental  hazards pro-
vides us with a guide, it  is likely  that im-
proved knowledge will show that there are
identifiable  health and welfare hazards  as-
sociated with air pollution levels that were
previously thought to be innocuous. As our
scientific  knowledge  grows, air quality cri-
teria  will have to be reviewed and,  in  all
probability,  revised.  But the Congress has
made it clear that we are  expected, without
delay, to  make the most effective use of  the
knowledge we now have.
  The Air Quality Act of 1967 requires that
the Secretary of Health, Education, and Wel-
fare ". . . from time to time, but as soon as
practicable, develop and issue to the  States
such criteria of air quality as in his judgment
may be requisite for the  protection of the
public health and welfare.  . . . Such criteria
shall . . . reflect the  latest scientific knowl-
edge useful in indicating the kind and extent
of all identifiable effects on health and wel-
fare which may be expected from the pres-
ence of an air pollution agent. ..."
  Under the Air Quality Act, the issuance of
air quality criteria is a vital step in a pro-
gram designed to assist the States in taking
responsible  technological, social, and  politi-
cal  action to protect the public from the ad-
verse effects of air pollution.
  Briefly, the Act calls for the Secretary of
Health, Education, and Welfare to define the
broad  atmospheric areas  of  the  Nation in
which  climate, meteorology, and topography,
all of which influence the capacity of air to
dilute  and disperse pollution, are generally
homogeneous.
  Further, the Act requires the Secretary to
define  those  geographical regions  in the
country where air pollution is a  problem—
whether interstate or intrastate.  These  air
quality control regions will be designated on
the basis of meteorological, social, and po-
litical factors which suggest that  a group of
communities should be treated as  a unit for
setting limitations on concentrations of  at-
mospheric pollutants. Concurrently, the Sec-
retary is required to issue air quality criteria
for those pollutants he believes may be harm-
ful to  health  or welfare, and to publish  re-
lated  information on  the techniques  which
can be employed  to  control the  sources of
those pollutants.
  Once these  steps have been taken for any
region, and  for any pollutant or combination
of pollutants, then the State or States respon-
sible for the designated region are on notice
to develop ambient air quality standards ap-
plicable to the region for the pollutants  in-
volved,  and to develop plans  of  action for
implementing the standards.
  The Department of Health, Education, and
Welfare will  review, evaluate and approve
these standards and plans, and once they are
approved, the States will be expected to take
action to control pollution sources in the man-
ner outlined in their plans.
  At the direction of the Secretary, the Na-
tional Air Pollution Control Administration
has  established  appropriate  programs  to
carry out the several Federal responsibilities
specified in the legislation.
  Air Quality Criteria for Particulate Mat-
ter is the culmination of intensive and dedi-
cated effort on the part of many persons—so

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many, in fact, that it is not practical to name
all of them.
  In accordance with the Air Quality Act, a
National Air Quality Criteria Advisory Com-
mittee was established,  having a  member-
ship broadly representative of industry, uni-
versities, conservation interests, and all lev-
els  of government.  The  committee,  whose
members are listed following this discussion,
provided invaluable advice on policies and
procedures under which to issue criteria, and
provide major assistance in drafting this
document. To facilitate the committee's work,
subcommittees were formed to provide inten-
sive efforts relating to specific pollutants—
initially for particulate matter and for sul-
fur oxides.
  With the help of the Subcommittee on Par-
ticulate Matter, expert consultants were re-
tained to draft portions  of  this document,
with other segments  being drafted by staff
members of the National  Air Pollution Con-
trol Administration. After the initial draft-
ing, there followed a sequence of review and
revision by the subcommittee, and by the full
committee, as well as by individual review-
ers especially selected for their competence
and expertise in  the  many fields of science
and technology related to the problems of at-
mospheric  pollution by  particulate  matter.
These efforts, without which this document
could not have been completed successfully,
are acknowledged individually on the follow-
ing pages.
  As also required by the Air Quality Act of
1967, appropriate  Federal  departments and
agencies, also listed on the following pages,
were consulted prior to issuing this  criteria
document. A Federal consultation committee,
comprising members designated by the heads
of seventeen departments and agencies, re-
viewed the document, and met with staff per-
sonnel of the National Air Pollution  Control
Administration to discuss their comments.
  This Administration is pleased to acknowl-
edge the efforts of each of the persons specif-
ically named, as well as the many not named
who contributed to the  publication  of this
volume. In the last analysis, however, the Na-
tional Air Pollution Control Administration
is responsible for its content.
                    JOHN T. MIDDLETON,
       Commissioner, National Air Pollution
                    Control Administration
       IV

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         NATIONAL  AIR  QUALITY CRITERIA ADVISORY COMMITTEE

                                     Chairman
                        DR. JOHN T. MIDDLETON, Commissioner
                     National Air Pollution Control Administration
Dr. Herman R. Amberg
Manager, Manufacturing Services Dept.
Central Research Division
Crown Zellerbach Corp.
Camas, Wash.

Dr. Nyle C. Brady
Director, Agricultural Experiment
  Station
Cornell University
Ithaca, N.Y.

Dr. Seymour Calvert
Director, Statewide Air Pollution
  Research Center
University of California, Riverside
Riverside, Calif.

Dr. Adrian Ramond Chamberlain
Vice President
Colorado State University
Fort Collins, Colo.

*Dr. Raymond F. Dasmann
Senior Ecologist
Conservation Foundation
Washington, D.C.

Mr. James R. Garvey
President and Director
Bituminous Coal Research, Inc.
Monroeville, Pa.

Dr. David M. Gates
Director
Missouri Botanical Gardens
St. Louis, Mo.
  * Resigned, October 14, 1968.
Dr. Neil V. Hakala
President
Esso Research & Engineering Co.
Linden, N.J.

Dr. Ian T. Higgins
Professor, School of Public Health
The University of Michigan
Ann Arbor, Mich.

Mr. Donald A. Jensen
Executive Engineer
Ford Motor Co.
Dearborn, Mich.

Dr. Herbert E.  Klarman
Professor  of Public Health Administration
  and Political Economy
School of Hygiene and Public Health
Johns Hopkins University
Baltimore, Md.

Dr. Leonard T. Kurland
Professor  of Epidemiology
Mayo Graduate School of Medicine
Head, Medical Statistics
Epidemiology and Population Genetics
   Section, Mayo Clinic
Rochester, Minn.

Dr. Frederick Sargent II
Dean, College of Environmental
  Sciences
University of Wisconsin
Green  Bay, Wis.

Mr. William J. Stanley
Director, Chicago Department of
  Air Pollution Control
Chicago, 111.

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                       CONTRIBUTORS  AND  REVIEWERS
Dr. Donald F. Adams
Head, Air Pollution  Research Division
College  of Engineering
Washington  State University
Pullman, Wash.

Dr. Mary 0. Amdur
Associate Professor of Toxicology
Department of Physiology
School of Public Health
Harvard University
Boston,  Mass.

Dr. Rodney R. Beard
Executive Head, Department
  of Preventive Medicine
Stanford University Medical School
Palo Alto, Calif.

Dr. Francis E. Blacet
Emeritus Professor of Chemistry
University of California at Los Angeles
Los Angeles, Calif.

Dr. L. J. Brasser
Head, Atmospheric Pollution Division
Research Institute for
  Public Health Engineering
Delft, The Netherlands

Dr.  Leslie  A. Chambers
Professor and Chairman
Department of Environmental Health
School  of Public Health
University of Texas
Houston, Tex.

Dr. Robert Charlson
Research Associate Professor of
   Atmospheric Chemistry
Department of Civil Engineering
University of Washington
Seattle, Wash.

Dr.  Morton Corn
Associate Professor, Department of
   Occupational Health
Graduate School  of Public Health
University of Pittsburgh
Pittsburgh, Pa.
Dr. Ellis F. Darley
Plant Pathologist
Statewide Air Pollution Research Center
University of California at Riverside
Riverside, Calif.

Dr. Arthur DuBois
Department of Physiology
Graduate School of Medicine
University  of  Pennsylvania
Philadelphia, Pennsylvania

Dr. James G. Edinger
Professor of Meteorology
University of California
Los Angeles, Calif.

Dr. Lars Friberg
Chief, Department  of Hygiene
Karolinska Institute of Hygiene
Stockholm, Sweden

Dr. Sheldon K. Friedlander
Professor of  Chemical Engineering
  and Environmental  Health Engineering
California Institute of Technology
Pasadena, Calif.

Dr. John R. Goldsmith
Chief, Environmental Hazards
  Evaluation Unit
Department of Public  Health
State of California
Berkeley, Calif.

Dr. Leonard Greenburg
Professor of Preventive and
  Environmental Medicine
Albert Einstein College of Medicine
New York, N.Y.

Dr. Alexander Goetz
Senior Staff  Consultant
National Center for Atmospheric
   Research
Altadena, Calif.

Dr.  Paul Gross
Director, Research Laboratory
Industrial Hygiene Foundation of
   America, Inc.
Mellon  Institute
Pittsburgh, Pa.

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 Dr.  Harry Heimann
 Research Associate, Department of
  Physiology
 School of Public Health
 Harvard University
 Boston, Mass.

 Dr.  Walter  W. Holland
 Professor, Department of  Clinical
  Epidemiology and Social Medicine
 St.  Thomas' Hospital Medical School
 University of London
 London, England

 Mr. John H. Jacobs
 Principal Research Physicist
 Bell  & Howell Research Center
 (Chicago, 111.)
 Pasadena, Calif.

 Dr. P. E. Joosting
 Medical Service
 Research Institute for
  Public Health Engineering
 Delft, The Netherlands

 Mr.  Elmer R. Kaiser
 Senior Research  Scientist
 School of Engineering and Science
 New York University
 New York, N. Y.

 Dr. Herbert Landesman
 Consulting Chemist
 Pasadena, Calif.

 Dr.  Phillip  A.  Leighton
 Emeritus Professor of Chemistry
 Stanford University
 Palo Alto, Calif.

 Dr.  Mark H. Lepper
 Professor of Preventive  Medicine
 University of Illinois College
  of Medicine
 Chicago, 111.

 Mr.  Robert  H. Linnell
 Staff Associate, Departmental Science
  Development  Section
 National Science  Foundation
 Washington, D.C.

Mr. Benjamin Linsky
Professor, Department of Civil Engineering
West Virginia University
Morgantown, W. Va.
Dr. James P. Lodge
Program Scientist, National  Center
  for Atmospheric Research
Boulder, Colo.

Dr. Thomas C. Lloyd, Jr.
Associate  Professor, Department of
  Physiology
School of  Medicine
Case Western Reserve University
Cleveland,  Ohio

Mr.  John A. Maga
Executive Officer
Air Resources Board, State of
  California
Sacramento, Calif.

Dr. Roy McCauldin
Professor, Department of Environmental
  Engineering
College of  Engineering
University of Florida
Gainesville, Fla.

Dr. Herbert  C.  McKee
Assistant  Director, Department  of
  Chemistry  and Chemical  Engineering
Southwest Research Institute
Houston, Tex.

Dr. Paul  E.  Morrow
Professor  of Radiation  Biology and
  Biophysics
School of  Medicine and Dentistry
University of Rochester
Rochester, N. Y.

Dr. Edward  D.  Palmes
Professor  of Environmental  Medicine
Institute of Environmental  Medicine
New York University Medical Center
New York, N. Y.

Dr. James N. Pitts, Jr.
Professor of Chemistry
University of California at  Riverside
Riverside,  Calif.

Dr. Walter A. Quebedeaux, Jr.
Director, Harris County Air
  and Water Pollution Control Division
Houston, Tex.
                                                                           Vll

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Dr. Donald D. Reid
Professor of  Epidemiology and Director
  of Department
Department of Medical Statistics and
  Epidemiology
London School of Hygiene and
  Tropical Medicine
London, England

Dr.  Elmer Robinson
Chairman, Environmental Research
  Department
Stanford  Research Institute
Menlo Park, Calif.

Dr. Stanley N. Rokaw
Chief, Pulmonary Research Section
Rancho Lcs Amigos  Hospital
Los Angeles,  Calif.

Dr. August T. Rossano
Professor, Air Resources Program
Department of Civil Engineering
University of Washington
Seattle, Wash.

Mr. Jean J. Schueneman
Chief, Division of Air Quality Control
Maryland State Department of Health
Baltimore, Md.

Dr. Wayne T. Sproull
Consultant in Physics
Pasadena, Calif.

Dr.  Gordon H. Strom
Department of Aeronautical
  Engineering
College of Engineering
New York University
New York, N. Y.

Dr. 0. Clifton Taylor
Associate Director
Statewide Air Pollution Research Center
University of California at Riverside
Riverside, Calif.
Dr. Moyer D. Thomas
Editor, Inter-Society Committee Manual of
  Methods for Ambient Air Sampling and
  Analysis
Riverside, Calif.
Dr. Amos Turk
Professor, Chemistry  Department
The City College of the City University
  of New York
New York, N. Y.

Mr. Hans K. Ury
Special Consultant
Environmental Hazards Evaluation Unit
California State Department of Public Health
Berkeley, Calif.

Mr. Ralph C. Wands
Director, Advisory Center on Toxicology
National Research Council
Washington, D.C.

Dr. Richard P. Wayne
Oxford University
London, England
Visiting Professor in Photochemistry
University of California at Riverside
Riverside, Calif.
Dr. Phillip W. West
Professor of Chemistry
College of Chemistry and Physics
Louisiana State University
Baton Rouge, La.
Dr. Warren Winkelstein, Jr.
Professor and Head, Division of
  Epidemiology
School of Public Health
University of California
Berkeley, Calif.
Dr. Harold Wolozin
Professor and Chairman
Economics Department
University of Massachusetts
Boston, Mass.
Mr. John E. Yocom
Senior Research Engineer
Travelers Research Center, Inc.
Hartford, Conn.
       via

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               FEDERAL AGENCY LIAISON  REPRESENTATIVES
Department of Agriculture
Kenneth E. Grant
Associate Administrator
Soil Conservation Service

Department of Commerce
Paul T. O'Day
Staff Assistant to the Secretary

Department of Defense
Colonel Alvin F. Meyer, Jr.
Chairman
Environmental Pollution Control Committee

Department of Housing and Urban
  Development
Charles M. Haar
Assistant Secretary for Metropolitan
  Development

Department of the Interior
Harry Perry
Mineral Resources Research Advisor

Department of Justice
Walter Kiechel, Jr.
Assistant Chief
General Litigation Section
Land and Natural Resources Division

Department of Labor
Dr. Leonard R. Linsenmayer
Deputy Director
Bureau of Labor Standards

Department of Transportation
William H. Close
Assistant Director for Environmental
  Research
Office of Noise Abatement
Department of the Treasury
Gerard M. Brannon
Director
Office of Tax Analysis

Federal Power Commission
F. Stewart Brown
Chief
Bureau of Power

General Services Administration
Thomas E. Crocker
Director
Repair and Improvement Division
Public Buildings Service

National Aeronautics and Space
  Administration
Major General R. H. Curtin, USAF (Ret.)
Director of Facilities

National Science Foundation
Dr. Eugene W. Bierly
Program Director for Meteorology
Division of Environmental Sciences

Post Office Department
Louis B. Feldman
Chief
Transportation Equipment Branch
Bureau of Research and Engineering

Tennessee Valley Authority
Dr. F. E.  Gartrell
Assistant Director of Health

Atomic Energy Commission
Dr. Martin B. Biles
Director
Division of Operational Safety

Veterans Administration
Gerald M. Hollander
Director of Architecture and Engineering
Office of Construction
                                                                           IX

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           AIR  QUALITY  CRITERIA  FOR
                PARTICULATE  MATTER

                     TABLE  OF CONTENTS
Chapter                                                           Pa»e
      Preface                                                 .     iii
      Introduction                                                 xiii
   1  Atmospheric  Particles:  Definitions, Physical Properties, Sources
      Concentrations                                                 1
   2  Effects of Atmospheric Particulate Matter on Solar Radiation and
      and Climate Near the Ground                                   33
   3  Effects of Atmospheric Particulate Matter on Visibility              47
   4  Effects of Atmospheric Particulate Matter on Materials              63
   5  Economic Effects of Atmospheric Particulate Matter                77
   6  Effects of Atmospheric Particulate Matter on Vegetation             87
   7  Social Awareness of Particulate Pollution                          97
   8  Odors Associated with Atmospheric Particulate Matter             103
   9  The Respiratory System: Deposition, Retention, and  Clearance of
      Particulate Matter                                            109
  10  Toxicological  Studies  of Atmospheric Particulate Matter            127
  11  Epidemiological Appraisal of Atmospheric Particulate Matter        145
  12  Summary and Conclusions                                     179

Appendices
A—Symbols                                                       192
B—Abbreviations                                                  193
C—Conversion Factors                                        .      194
D—Glossary                                        .              195
Author Index                                        .              204
Subject Index                                                      208
Acknowledgements     .                              .              211
                                                                      XI

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                                INTRODUCTION
  Pursuant to  authority  delegated to the
Commissioner of the National Air Pollution
Control Administration, Air Quality Criteria
for Particulate  Matter is  issued  in  accord-
ance with Section 107bl of the Clean Air Act
(42U.S.C. 1857c-2bl).
  Air  quality criteria are an expression of
the scientific knowledge of the relationship
between various concentrations of pollutants
in the  air and their adverse  effects on man
and his environment. They are issued to as-
sist  the States  in  developing air  quality
standards.  Air quality criteria  are descrip-
tive; that is, they  describe the effects that
have been  observed to occur when the am-
bient air level of a pollutant  has reached or
exceeded specific figures for  a specific time
period. In developing criteria, many factors
have to be considered.  The chemical  and
physical characteristics of the pollutants and
the techniques available for measuring these
characteristics must  be  considered, along
with exposure time,  relative humidity, and
other conditions of the environment. The cri-
teria must consider the contribution of all
such variables to the effects of air pollution
on human health, agriculture, materials, vis-
ibility, and climate. Further, the  individual
characteristics of the receptor must be taken
into account. Table A, which appears at the
end of this introduction,  is a listing of the
major  factors that need to be considered in
developing criteria.1
  Air  quality  standards  are prescriptive.
They prescribe pollutant exposures which a
political jurisdiction  determines should not
be exceeded in a specified geographic  area,
  1 Calvert, S. Statement for air  quality criteria
hearings held by the Subcommittee on Air and Water
Pollution of the U.S.  Senate Committee on Public
Works.  July 30, 1968.
and are used as one of several factors in de-
signing legally enforceable pollutant emission
standards.
  The particulate  matter commonly found
dispersed in the atmosphere is composed of
a  large   variety  of  substances.  Some of
these—flourides, beryllium, lead, and asbes-
tos, for example—are known to be directly
toxic, although not necessarily at levels rou-
tinely found in the atmosphere today. There
may very well be  others whose toxic effects
have  riot yet been recognized. To evaluate
fully the effects on health and welfare of the
presence of each of these substances in the
air requires that they be given individual at-
tention, attention  as classes of similar sub-
stances,  or  that they  be  considered  in con-
junction  with other substances where syner-
gistic effects  may occur.  Such evaluations
will be made at a later time in separate docu-
ments.
  This document focuses on total particulate
matter of the kind normally measured by
high-volume sampling methods, by  paper-
tape sampling methods, and by dustfall col-
lection. Further, this document considers the
effects of particulate matter  in conjunction
with some gaseous materials, such as sulfur
dioxide, where important synergistic effects
are observed.  (Atmospheric sulfur oxides
are treated  in detail in a companion  criteria
document: Air  Quality Criteria for Sulfur
Oxides.)  No attempt is  made in this  docu-
ment  to  set up dose-response  relationships
for specific particulate pollutants.  Also,  the
large  and  diverse  contributions of agricul-
tural  and forest management operations to
air pollution, such as insecticide spraying and
slash  burning, .and the ingestion hazard to
animals and man of toxic particulate matter
deposited on plant materials, are treated only
for a few selected  examples;  details  are be-
                                                                             Xlll

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yond the scope of this document.
  Methods of measuring the effects of partic-
ulate matter on meteorological conditions, at-
mospheric visibility, and materials are docu-
mented,  as well as is the resulting economic
loss. The effects  of particulate matter are
further considered as they relate to vegeta-
tion damage. Public awareness of air  pollu-
tion and the role of particulate matter  in the
odor problem are assessed. There is a  chap-
ter on the respiratory  system,  and particu-
late deposition therein and removal  there-
from, necessary to understanding of the final
chapters  which survey  toxicological  effects
of particulate matter and the epidemiological
data for man and animals.
  In general, the terminology employed fol-
lows usage recommended in the publications
style guide  of  the American Chemical So-
ciety. A glossary of terms, list of symbols and
abbreviations list of conversion factors for
various units of measurement, author  index,
and subject  index  are provided.
  The literature has been generally reviewed
on  a worldwide basis through  March 1968.
The results  and conclusions  of foreign in-
vestigations  are evaluated for their possible
application to the air  pollution problem in
the  United  States. This document is not in-
tended as a  complete, detailed literature re-
view, and it does not  cite every  published
article related  to  atmospheric particulates.
However, the literature has  been reviewed
thoroughly  for information  related to the
development  of criteria,  and the  document
not  only summarizes the current scientific
knowledge of particulate  air pollution, but
points  up  the major  deficiencies  in that
knowledge and the need for further research.
  Technological and economic aspects  of air
pollution control are considered in compan-
ion volumes to criteria documents. The best
methods available for controlling the sources
of  particulate air pollution,  as well as the
costs of  applying  these  methods,  are de-
scribed in:  Control  Techniques for Particu-
late Air Pollutants.
 Table A.—FACTORS TO BE  CONSIDERED IN
    DEVELOPING AIR QUALITY CRITERIA

Properties of Pollution:
    Concentration
    Chemical composition
    Mineralogical structure
    Adsorbed gases
    Coexisting pollutants
    Physical state of pollutant
       Solid
       Liquid
       Gaseous
    Rate of transfer to receptor domain
Measurement Methods:
    Hi-Vol sampler
    Spot-tape sampler
    Dust fall bucket (rate of deposition)
    Condensation nuclei counter
    Impinger (liquid filled)
    Cascade impactor
    Electrostatic precipitator
    Light scattering meter
    Chemical analysis
    Gas analysis (non-adsorbing)
    Adsorbed gas analysis
    Light scattering or attenuation
       (Ringleman or visibility observation)
    Colored suspension
    Nucleation of precipitation
    Stabilization of fog
    Odor
    Taste
Exposure Parameters:
    Duration
    Concomitant conditions, such as
       Temperature
       Pressure
       Humidity
Characteristics of Receptor:
    Physical characteristics
    Individual susceptibility
    State of health
    Rate and site of transfer to receptor
Responses:
    Effects  on health (diagnosable effects, latent
      effects, and effects predisposing the organism
      to disease) :
       Human health
       Animal health
       Plant health
    Effects on human comfort
    Soiling
    Other objectionable surface deposition
    Corrosion of materials
    Deterioration of materials
    Effects on atmospheric properties
    Effects on radiation and temperature
       XIV

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                  Chapter 1
ATMOSPHERIC PARTICLES: DEFINITIONS, PHYSICAL
  PROPERTIES, SOURCES, AND CONCENTRATIONS

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                            Table of Contents


A. INTRODUCTION                      	
B. PROPERTIES OF ATMOSPHERIC PARTICIPATE MATTER  .
   1. Surface Properties       .           .       	
   2. Motion .                             	
   3. Optical Properties
C. CHEMICAL REACTIONS  OF ATMOSPHERIC PARTICULATE
   MATTER                           .      	
D. SOURCES OF ATMOSPHERIC PARTICULATE MATTER      . .
E. ATMOSPHERIC PARTICULATE MATTER IN URBAN AREAS.
   1. Suspended Particulate Matter           	
   2. Dustfall           	                   	
F. SAMPLING AND ANALYSIS OF ATMOSPHERIC
   PARTICULATE MATTER
   1. Particles Larger than 10^                             .  .
   2. Particles 0.1,* to 10ft                     	
     a. Tape Samplers for Suspended Particulate Matter
     b. High-Volume Samplers for Suspended Particulate Matter .
   3. Particles Smaller than O.L/                    	
G. SIZE, CHEMICAL COMPOSITION, AND SOURCE STRENGTHS
   OF  PARTICULATE  MATTER  FROM SELECTED  EMISSION
   SOURCES     .                            	
   1. Open Hearth Furnaces
     a. Chemical Composition   .   .              .     	
     b. Particle Size           	            .      ....
   2. Incineration
     a. Chemical  Composition              	
     b. Particle Size                         .    .      .   .   ..
   3. Sulfuric Acid Manufacture: Chamber Process	
     a. Chemical  Composition           .         	
     b. Particle Size      .        .             .  .      	
   4. Sulfuric Acid Manufacture: Contact Process    .          . .
     a. Chemical  Composition          . .
     b. Particle Size           	
   5. Cement Plants      .           	      	
     a. Chemical  Composition   .      .     .     .    	
     b. Particle Size           .                  	
   6. Motor Vehicles          .
     a. Chemical  Composition .         . .       	
     b. Particle Size     	          	
     Fuel Oil  Combustion
7.
   8.
  a. Chemical  Composition
  b. Particle Size
  Combustion of Coal
  a. Chemical  Composition
  b. Particle Size
                                                               Page
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                                                                         Page
H. SUMMARY                                           	          27
I.  REFERENCES   .   . .                    .         	       29

                          List of  Figures
Figure
1-1  Sizes of Atmospheric Particulate Matter            .       .            6
1-2  Setting Velocities in Still Air at 0°C and 760 mm Pressure for Par-
     ticles Having a Density of 1 g/cm3 as a Function of Particle Diameter      7
1-3  Log-Normal Distribution of Particles Showing Various Average         7
     Diameters
1-4  Particle Size Distribution of Figure 1-3, Plotted Logarithmically         7
1-5  Cumulative Log—probability Curve for the Distribution of
     Figure 1-4                                                          8
1-6  Horizontal Elutriator Cut-off  Characteristics            .     ...      17
1-7  Dustfall Data for Six Cities                          .                18

                          List of Tables
Table
1-1  Emission Inventory of Particulate Material, Tons  Per  Year            12
1-2  Suspended Particle Concentrations (Geometric  Mean  of Center
     City Station)  in Urban Areas, 1961 to 1965                           13
1-3  Distribution  of Selected Cities by  Population  Class  and  Particle
     Concentration, 1957 to 1967                                          15
1-4  Distribution  of Selected  Nonurban  Monitoring Sites  by Category
     of Urban Proximity, 1957 to 1967               .             .   .     15
1-5  Arithmetic Mean and Maximum Urban Particulate Concentrations
     in the United States, Biweekly Samplings,  1960  to 1965                16
1-6  Emission Factors  for  Selected Categories  of  Uncontrolled Sources
     of Parti culates                     .                      ...      24

-------

-------
                                      Chapter  1

    ATMOSPHERIC PARTICLES:  DEFINITIONS, PHYSICAL PROPERTIES,
                        SOURCES, AND CONCENTRATIONS
           A.  INTRODUCTION

   Atmospheric  particles are  chemically  a
most diverse class of substances; they do,
however, have a number of physical proper-
ties in common, and for this reason are gen-
erally classed in a single category, sometimes
referred to as aerosols.
   Some workers restrict the concept of par-
ticulate matter to the solid phase; this dis-
tinction is, however, difficult to make in prac-
tice and is probably not proper. Others refer
to  airborne  particles as  nuclei because  of
their role in the nucleation of condensation,
especially of liquid or solid water. In this
document, the term "particle" is used to mean
any dispersed matter, solid or liquid in which
the  individual aggregates are  larger than
single small molecules (about 0.0002/t  in di-
ameter), but smaller than about 500/x. [One
micron (/*) is one-thousandth of a millimeter
or one-millionth of a meter.] Particles in this
size range have a life-time in the suspended
state varying from a few seconds  to several
months.
  Many disciplines  are involved in the  study
of particles,  and each appears to have devised
its own system of nomenclature to differenti-
ate classes of particles with respect to size,
physical state, origin, etc. Periodic, but rath-
er unsuccessful attempts have been made  to
resolve the confusion.1 The present document
will discuss the several classes of particles by
specifying the size or size interval in microns
(AI)  and,  where  appropriate,  the  physical
state. Figure 1-1 provides a graphic scheme
for relating meteorologic nomenclature for
aerosols to the particle sizes. Nonspherical
particles  may be idealized as spheres which
would have the same settling rate, but even
so,  size designations have frequently been
 ambiguous. For example,  "size" has  been
 taken to mean both  diameter and  radius.
 Again some workers interpret size to mean
 the physical or geometrical size, while others
 mean  some equivalent size based,  for ex-
 ample,  on optical laws relating  the  size of
 aerosol particles to the measured scattering
 of a light beam. In this document,  "size" ordi-
 narily refers to particle diameter or  Stokes'
 diameter as defined below.
  Particles larger than about a micron in di-
 ameter settle in still air at velocities approxi-
 mated by Stokes' Law:
        gd2
                                     (1-D
            1871
where
         v  is  velocity in cm/sec  (settling
            velocity or terminal velocity),
         g  is  the acceleration of gravity in
            cm/sec2,
         d  is  particle diameter in cm,
         PI  and p., are the densities of the
            particle and of air respectively
            in  g/cm3, and
         7i  is viscosity of air in poise.
The expression is  precisely  true only  for
spheres. An upper limit to its applicability is
set by the fact that, when a certain  settling
velocity is reached, the particle generates a
significant "wake". A lower limit is reached
when  the particles become  small enough,
around 1/x, that air resistance is no  longer
continuous but is rather the result of individ-
ual collisions with air molecules. Under these
conditions the particles "slip"  between mole-
cules  and the  Stokes' equation underesti-
mates  their  falling velocity. Correction fac-
tors exist to allow for this behavior, but they
need not be given here for the qualitative dis-
cussion which follows.  The approximate set-

-------
     NOMENCLATURE
           ATOMS,
         MOLECULES
         (Not Particles)
            AIR
         ELECTRICITY
        ATMOSPHERIC
           OPTICS
                                                                       Active
                                                                     Condensation
                                                                       Nuclei
  CLOUD
 PHYSICS
                                                                 Particles
                                                               Which Contain
                                                              Main Aerosol Mass
   AIR
CHEMISTRY
                                                                  Suspended
                                                               Particulate Matter
       ROUTINE AIR
       POLLUTION
     MEASUREMENTS
                                            10-
                                          DIAMETER.fi
FIGURE 1-1. Sizes of Atmospheric Particulate Matter2  (The figure shows the ranges of particle size  (diam-
         eter) of various types of participate matter which are found in the earth's atmosphere.)
tling velocities in still air at 0°C and 760 mm
pressure for particles having a density of 1
g/cm3 are:
     0.1/i, 8 x 10~5 cm/sec; 1/t, 4 x 1(H cm/sec;
     10/i, 0.3 cm/sec; 100//., 25 cm/sec; and
     1,000/t, 390 cm/sec. (See Figure 1-2.)
  In the case of a nonspherical particle, sub-
stitution of  v, g, Pl, p2,  and n in equation
(1-1), Stokes Law, leads to a fictitous diam-
eter, d, which is known as the  Stokes or aer-
odynamic diameter. Unless otherwise stated,
the word "diameter," as  applied to particles
suspended  in air or gas,  ordinarily means
Stokes diameter.
  If the density, />,  of the particles is not
known, it may arbitrarily be assigned a value
of 1 g/cm 3; in this  case d is  no longer the
"Stokes  diameter" but rather  the "reduced
sedimentation diameter"—that is, the diam-
eter of a spherical particle of unit density
having the same terminal fall velocity in still
air as the particles in question.
  The geometrical diameter of a particle will
be smaller than the reduced sedimentation di-
ameter if the particle has  a density greater
                                     than 1. A few quantitative examples can be
                                     given:3 a l-/t sphere of lead with a density of
                                     approximately 11 has a reduced sedimenta-
                                     tion diameter of 3.4,*; a bubble of air in water
                                     with an outer  diameter of I/* and a water
                                     film thickness of 0.1/t and consequently a den-
                                     sity of approximately 0.5 g/cm3 has a reduced
                                     sedimentation diameter of 0.7/t. Nonspherical
                                     particles  can also be assigned a "diameter"
                                     based on their settling rate.  A rectangular
                                     plate of density 1 g/cm3, and dimensions 5 X
                                     5x0.5ju, has a  reduced sedimentation diam-
                                     eter near 2/j..
                                        Some of the  smallest particles may be no
                                     more  than  statistical  aggregations of gas
                                     molecules  which act as a particle at one in-
                                     stant and cease to exist at the next.  Solid
                                     particles  and liquid droplets may be formed
                                     in the atmosphere by condensation of  a va-
                                     por. Solid particles produced by abrasion or
                                     grinding  are not  sphercial and  are called
                                     dust.
                                        This discussion  of size classes  must not
                                     obscure the fact that there is a continuous
                                     spectrum of sizes among the particles in the

-------
                                                               COUNT MODE (0.619/i)
                                                               COUNT MEDIAN (1.0//>
                                                               ARBITRARILY SET AT ONE
                                                                COUNT MEAN (1.272U)
                                                                     DIAMETER OF AVERAGE
                                                                     MASS (2.056 H)
                                                                       AREA MEDIAN (2.614W

                                                                           AREA MEAN (3.324 JZ)

                                                                             MASS MEDIAN (4.226U)
                                                                                     MASS MEAN -
                                                                                     (5.374/Z)
                                                                  2345

                                                                PARTICLE DIAMETER, U
  ID'1
     10-
            DIAMETER OF PARTICLE, MICRONS
FIGURE 1-2. Settling Velocities in Still Air at 0° C
  and 760 mm Pressure for Particles Having a Den-
  sity of  lg/cm3 as a Function of Particle Diameter.
  (This graph shows that, for spherical particles of
  unit density suspended in air near sea level, Stokes
  law applies over a considerable range of particle
  sizes, where the line is straight, but that correction
  is required  at the extremes where the line begins
  to curve.)
atmosphere and a corresponding  continuous
gradation of all their size-dependent proper-
ties. The distribution of particle sizes usually
encountered  approximates  closely a log-nor-
mal distribution.  In this  distribution, the
familiar  symmetrical bell-shaped probabili-
ty curve appears for a frequency graph plot-
ted against the logarithm of the particle size.
In this graph, the ordinate is the number of
particles per unit log (particle size)  interval.
Figures  1-3  and  1-4  show the  direct and
logarithmic frequency distribution curves for
for the log-normal distribution. In practice, a
cumulative distribution is plotted on special
graph  paper  with  log-probability scales so
FIGURE  1-3.  Log-normal Distribution  of Particles
  showing Various Average Diameters.1  (The graph
  is drawn from probability theory, assuming a count
  median diameter of lju,  and shows the numerical
  values relative to that diameter of several other
  weighted  average diameters discussed in the text.)
.0.5)
                 PARTICLE SIZE, JU

FIGURE 1-4. Particle Size Distribution of Figure 1-3,
  Plotted Logarithmically. (If the particle size distri-
  bution  is log-normal,  the graph is  symmetrical
  when plotted logarithmically. The figure should be
  contrasted with Figure 1-3.)

-------
that a straight line is obtained if the distribu-
tion is truly log normal; the best line is fitted
either by eye or mathematically. Such a plot
is shown in Figure 1-5, and the experimental
points give an idea of the extent to which the
size distribution of a typical industrial dust
approximates to log-normal.
  A  distribution  curve based  on an exact
mathematical function can  be specified in
terms of two  parameters. In the case of the
log-normal distribution, two frequently used
defining parameters are (1) the most proba-
ble size, which in this distribution is identical
with the geometric  mean, Mg,  and (2) the
geometric  standard  deviation, 
-------
specifically by a chemical interaction between
the surface and the gas, the process is known
as chemisorption. Absorption refers  to the
situation in which the gas is dissovled into
the  particle.
  A vapor (i.e., a gas below its critical tem-
perature) , present in amounts comparable to
its equilibrium vapor pressure, may lead to
a deepened sorbed layer, which then takes on
the character of a layer of true liquid or solid.
If the vapor is supersaturated, a droplet or
crystal may grow by further condensation on
the sorbed layer. The net result is nucleation,
a phenomenon which deserves more consid-
eration. A pure vapor, free of particles, must
be highly supersaturated before a condensed
phase  will form from it,  because an energy
barrier separates the molecular from the par-
ticulate state.
  Two like molecules of gas will not general-
ly stick together, and an  aggregate of three
molecules is still less  likely to retain its iden-
tity for any length of time. A small aggregate
of molecules is therefore unstable. On the
other hand, if a particle is split in two, energy
is required to create  the new surfaces, since
the  combined  surface area  of the two frag-
ments  is greater  than that of the original
particle (surface energy increases with a de-
crease in size). At  some point, these two
trends of decreasing stability meet at a maxi-
mum which corresponds to a certain particle
size. If a molecular aggregate can reach this
size, then the addition of a single molecule
puts it over the energy barrier and it will be- -
come more stable by collecting still more mol-
ecules. Conversely, the loss of a single mole-
cule  from a nucleus  of critical size can de-
stroy its stability with the probable  result
that it will return to the molecular or gaseous
state.
  The  important  point is  that  the critical
particle generally contains some tens of mole-
cules which must  all  come together at once.
Unless the vapor concentration is high, this
is an improbable event; for some substances,
homogeneous  nucleation  may  even require
supersaturations of many hundredfold. How-
ever, a complete sorbed layer on a particle
surface behaves like a drop of the same diam-
eter as the particle, and the energy barrier to
producing a droplet is avoided. Since parti-
cles  are always present in the atmosphere,
nucleation on them is of widespread occur-
rence.
  The last of the surface properties of conse-
quence is  adhesion.  All available evidence
suggests that solid particles with diameters
less  than l/i  (and liquid particles regardless
of size)  always adhere  when they  collide
with each other or with  a larger  surface.
Other factors being equal, reentrainment or
rebound becomes increasingly probable with
increasing particle  size.  Alternatively, the
adhesive property can be considered in terms
of the surface energy of small particles or
in terms  of the more complex shear forces
acting to dislodge  the larger particles.

                2.   Motion

  The second major class of properties com-
mon to all particles, regardless of composi-
tion, is their  mode of motion.  Particles with
sizes less than  0.1/t undergo large  random
(Brownian) motions caused by collision with
individual molecules.  Particles larger than
1/i have significant settling velocities,  and
their motions can vary significantly from the
motion of  the air in which they are borne.
For  particles between O.I/* and I/*, settling
velocities in still air, though finite, are small
compared with  air motions.  Despite fairly
high  concentrations, coagulation is  some-
what  slower  as  compared with  particles
smaller than 0.1/«  because  of  decreased
Brownian  motion.   Nevertheless,  the oper-
ation of this mechanism, together with the
processes which  generate larger particles and
which remove particles from the air, causes
the whole population of particulate matter in
the air to tend  towards  a constant size dis-
tribution.
  Although actual settling times  in  the at-
mosphere tend to differ from those computed
from Stokes  Law, because turbulence tends
to offset  gravitational  fall,  the  particles
larger than 5/x or 10/j. are removed to a large
extent by  gravity  and other inertial proc-
esses.
          3.   Optical Properties

  The final class  of physical  properties to
be discussed  is that of the behavior  of par-
ticles towards light. This behavior is clearly

-------
of importance in effects on visibility, and it
is through their optical effects that particles
are  usually  perceived  in the  atmosphere.
Once again, particles in the size range O.I/*
to Ip. exhibit properties showing a transition
between two extreme cases.
   Particles below O.l/* are sufficiently small
compared to the wavelength of light to obey
approximately the same laws of light scatter-
ing as molecules do. This so-called Rayleigh
scattering  varies as the sixth power of the
particle diameter and is fairly inconsequen-
tial in its effects on visibility. On the other
hand,  particles  very much larger than  1/x
are so much larger than the  wavelength of
visible light  that  they  obey the same laws
as macroscopic objects, intercepting or scat-
tering light roughly in  proportion to their
cross-sectional area.  Particles in the inter-
mediate size range obey complex scattering
laws  set forth by Mie;7 these laws are be-
yond the scope of the present discussion.  Be-
cause the particle dimensions are of the same
order of magnitude as the wavelength of visi-
ble radiation, interference phenomena play
a  complicating role, and a given scattering
behavior may correspond to several particle
sizes.  Unfortunately,  this  is precisely  the
size  range which  is most effective in light
scattering  and  thus most needful of study.
A more complete discussion of optical effects
is given in  Chapter 3.

     C.  CHEMICAL REACTIONS OF
      ATMOSPHERIC PARTICULATE
                MATTER
  In view  of the diverse chemical composi-
tions of particles,  it is not possible to make
general statements about the  chemical reac-
tions of  particulate atmospheric pollutants,
and the following discussion refers to some
specific reaction  systems that  have been
studied.  Both particle-gas and particle-par-
ticle reactions can occur, but the latter class
has been  studied  to an even lesser extent
than the former.  Such  particle-particle re-
actions should  certainly  occur  in the size
range  below 0.1/x  where collision between
particles is frequent, but, in particles large
enough to  be readily studied, collisions  are
relatively infrequent in the atmosphere  be-
cause of low concentrations. Samples of par-
ticles collected on filters may, however, react
and subsequent analysis can be very mislead-
ing if this fact is not taken into account.
  One of the particle-gas systems, the reac-
tion between sulfuric acid mist and ammonia
gas, was investigated by Robbins and Cadle.8
At high humidities the reaction rate was lim-
ited by  diffusion  of ammonia  to the mist
droplets.  At  low  humidities  the  droplets
were  viscous enough to result in diffusion of
the reaction product away from the surface
of the drops being the rate-determining step.
This work shows the effect of accumulation
of reaction products, and attempts to explain
the role  of humidity in a gas-particle reac-
tion.
  Goetz  and  Pueschel9  reported  a  study
which fully reveals the complexity  of even
a simplified model  of the photochemical air
pollution  found in  Los  Angeles.  The one
clear  relationship  is that  the  amount of re-
action product deposited on nuclei supplied
from  the gas phase is proportional to the
surface area of the nuclei.  The humidity ef-
fect  is  complex  and depends upon the
amounts and  the  order  of addition of the
other substances present.  The  obvious re-
actants (olefins, nitrogen  dioxide,  and sul-
fur dioxide) differ in action as well. Amounts
of  sulfur dioxide  of  the  order of 2 ppm
depress  aerosol  formation,  while  larger
amounts (15-16 ppm)  increase it. Nitrogen
dioxide is more effective if mixed with nuclei
before mixing with the olefin.
  Interactions  between sulfur  dioxide and
metal oxide aerosols have recently been stud-
ied by Smith et al.10 at ambient conditions of
temperature and humidity.  In measurements
that included an adsorption isotherm for sul-
fur dioxide on dispersed particles, preferen-
tial chemisorption on iron oxide and alumi-
num  oxide  aerosols was  observed  at low
sulfur dioxide concentrations (up to 2 ppm)
followed by multilayered physical adsorption
at higher concentrations.

    D.  SOURCES  OF ATMOSPHERIC
         PARTICULATE  MATTER
  In a broad  sense, particles in the atmos-
phere  are produced by  two mechanisms:
those  in the size range below l/i arise prin-
cipally by condensation, while  larger par-
       10

-------
tides  result  from  comminution,  although
there is considerable overlap.  For example,
Preining  et al.11  showed the  presence of
many particles smaller than l/j. in the spray
from a nebulizer, while the formation of very
small drops  during the rupture of bubbles
has been demonstrated.12 Dry grinding proc-
esses are rarely efficient in producing par-
ticle sizes  below a few microns because of
the rapid  increase in  energy necessary to
produce the additional surface.
   Combustion is complex in that it may pro-
duce four distinct types of particles.  These
may arise in the following ways:
   1. The heat may vaporize material  which
     subsequently  condenses to yield  parti-
     cles in the size range between 0.1/t and
     V,
   2. the energy available produces particles
     of very small size  (below O.l/*); these
     particles may be of short life as a result
     of their being simply unstable molec-
     ular clusters,
   3. mechanical processes may reduce  either
     fuel or ash to particle sizes larger than
     I/* and may entrain it,
   4. if  the fuel is itself an aerosol during
     combustion, a very fine ash may escape
     directly, and
   5. partial  combustion of fossil fuels may
     result in soot formation.
   Particles larger than 10/j,  frequently re-
sult from mechanical processes such as wind
erosion,  grinding,  spraying,  etc.,  although
raindrops,  snowflakes, hailstones, or  sleet
are obviously not  produced in this way.
   The sources of dust are usually apparent.
For example, a dustfall sample nearly always
contains particles of local soil. Another large
fraction  will  be materials dropped on the
ground and pulverized by vehicles, pedestri-
ans or  wind  action.   Although  actual soot
floes are increasingly absent as better home
heating is used,  there may be partially burnt
trash from  inefficient  incinerators.  Finally,
the process dust characteristic of local in-
dustry will  be present.  In urban  locations
particles between  1/x and 10/x  generally re-
flect industrial  and  combustion processes
with some local soil also present.  In  mari-
time locations, the bulk of the airborne sea
salt will be found in  particles  of  this size.
The finer process dusts  (ash, etc.) also fall
into this category. In  short,  atmospheric
particles in the l-/i to 10-/i range tend to have
a composition characteristic of local sources
and soil.
  As mentioned before, it is difficult to form
small particles by size reduction. The class
of  particles between O.l/* and 1/t compared
with the larger particles therefore tends to
contain increasing amounts of condensation
products. Products of combustion begin to
predominate  together  with  photochemical
aerosols. Particles below 0.1/< have not been
characterized  chemically but  the increase
over the natural level, characteristic of cities,
seems to be entirely the result of combustion.
  Table 1-1 shows typical particulate emis-
sion source data.  Section  G—1  gives some
typical  analytical  data on particulate matter
by  industry source.

    E.   ATMOSPHERIC  PARTICULATE
      MATTER  IN URBAN AREAS

     1.   Suspended Particulate  Matter
  The fraction of aerosol mass  in the par-
ticles below 0.1/x is small and concentrations
are  normally  reported in  number per unit
volume. Even the cleanest air rarely contains
fewer than  some  hundreds of particles per
cubic centimeter,  and  the particle count in
very polluted urban air 17 may reach 105/cm3.
  The bulk of current  data  on suspended
particles generally does not discriminate on
the basis of size.  Most data come  from the
National Air Surveillance Network (former-
ly the National Air Sampling Network.18-19
Blifford 20 has applied factorial  analysis to
these data to  show relationships among in-
dividual pollutant species.   Average  sus-
pended  particle mass  concentrations  range
from about  10 /*g/m3 in remote nonurban
areas to about 60  /ug/m3  in near urban loca-
tions. In urban areas, averages range from
60 /xg/m3 to 220 /ug/m3, depending on the size
of the  city  and  its industrial activity.  In
heavily  polluted areas, values of up to 2000
yug/m3 have been recorded.
  Table 1-2 lists the average suspended par-
ticle concentrations for a number of stand-
ard  metropolitan  statistical areas  through-
                                                                               11

-------
     Table 1-1.—EMISSION INVENTORY OF PARTICIPATE MATERIAL, TONS PER YEAR.
Metropolitan Area
Source Class
New York-
New Jersey l3

1966

Tons Percent
Fuel combustion
Power generation
Coal 	 ... .
Anthracite .
Bituminous
Fuel Oil
Distillate
Residual-
Natural Gas
Industrial
Coal
Anthracite
Bituminous
Fuel Oil
Distillate
Residual.. 	 . - -
Natural Gas
Domestic
Coal
Anthracite
Bituminous
Fuel Oil
Distillate
Residual
Natural Gas
Commercial and Government
Coal
Anthracite _
Bituminous
Fuel Oil
Distillate
Residual
Natural Gas
Refuse disposal _ . _ .
Incinerator _ _ _ .
Open burning
Transportation _ - - -
Motor Vehicles . _ 	
Gasoline
Diesel - . _ 	
Aircraft . _ _ .
Shipping _ - _
Railroads
Industrial Process
Asphalt Batching
Asphalt Roofing
Cement Plants
Chemical Plants
Coffee Processing
Coke Plant _ 	
Glass and Frit - 	 	
Grain Industry

134,
40,
31,

31,
7,

7,

33,
23,
8,
15,
9,
1,
8,

41,
17,
16,
1,
21,
15,
6,
1,
19,
8,
4,
3,
10,
3,
7

41,


35,
33,
22,
11,

1,

19,





__ Not
_- Not


410
042
722
47
675
593
593
727
599
442
022
420
569
479
090
588
073
767
561
206
580
326
254
726
696
139
432
707
894
281
613
663
734

245
761
630
131
,484"
914




reported
reported

58.1
17.3
13.7
13.7
3.3
3.3
14.5
10.5
3.5
6.7
4.1
0.6
3.5
17.8
7.7
7.2
0.5
9.3
6.6
2.7
0.7
8.5
3.5
1.9
1.6
4.7
1.4
3.3
18.0

15.2
14.6
9.8
4.8
0.6
8.6






Washington u

1965-66
St. Louis I5
1963
Tons Percent
19,
9,

9,

3,
1,
1,
5,
3,
3,
1,
1,
8,

280
912

890
22
19
3

351
135
135
182
23
159
34
166
735
685
50
839
154
685
592
851
891
153
738
814
661
153
146
155

6,245
5,678
4,031
1,647
410
157
1,110




Not
Not





reported
reported

55
28

28
0
0

1
0
0
0
0
0
0
9
2
2
0
5
3
2
1
16
11
0
10
5
1
3
0
23

18
16
11
4
1
0
3






.4
.5

.4
.1
.1

.0
.4
.4
.5
.1
.5
.1
.1
.1
.0
.1
.3
.3
.0
.7
.8
.2
.4
.7
.2
.9
.3
.4
.4

.0
.3
.6
.7
.2
.5
.2






Tons
86,800
22,400
22,400




68
39,000
37,990

683

423
19,900
18,873

671

354
5,500
5,450

34

27
15,800
1,700
14,100
7,100
4,700
4,100
600
211
670
1,500
37,500
198
NA
3,600
NA
38
73
NA
6,695
Percent
58.9
15.2
15.2





26.5
25.8

0.5

0.3
13.5
12.8

0.5

0.2
3.7
3.7





10.7
1.2
9.6
4.8
3.2
2.8
0.4
0.1
0.5
1.0
25.4
0.1
2.4



4.5
Los Angeles w
1965

Tons Percent
8,580
4,825






730






2,425






18.8
10.5






1.6






6.6






Included with
domestic





365
365
21,535
17,155
16,425
730
4,015
365 b
13,865
365
1,095
No plants
2,920
Not reported
No plants
730
Not reported





0.8
0.8
47.0
37.5
35.9
1.6
8.8
0.8
33.5
0.8
2.4
6.8
1.6
See footnotes at end of table.
     12

-------
  Table 1-1 (continued).—EMISSION INVENTORY OF PARTICULATE  MATERIAL, TONS  PER YEAR.
          Source Class
 New York-
New Jersey 13
                                      1966
                                                          Metropolitan Area
Washington 14
St. Louis 15
                                 Los Angeles 16
 1965-66
   1963
                                       1965
                                  Tons   Percent   Tons   Percent   Tons    Percent    Tons   Percent
Metals	
    Ferrous	
    Nonferrous	
Solvent Uses c	
Sulfuric Acid Mfg	
Superphosphate  Mfg_
Other	
               12,433
               12,392
                   41
                 NA
                 192
                 223
               14,063
          8.3
          8.3
                             0 . 1
                             0.2
                             9'.5
                                   2,920
                                   1,460
                                   1,460
                                   5,470
                                                                6.4
                                                                3.2
                                                                3.2
                                                               11.9
               Not reported
               No plants
                   365      0.8
      Total	  231,303    100.0   34,790    100.1   147,400    100.0   44,345
                                          100.0
    • Both aircraft and shipping.
    b Both shipping and railroads.
° Includes chemical plant emissions of solvents.
NA Not available.
Table 1-2.—SUSPENDED PARTICLE CONCENTRATIONS (GEOMETRIC MEAN  OF CENTER CITY STA-
                                TION) IN URBAN AREAS, 1961 TO 1965.
           Standard metropolitan statistical area
         Total
    suspended particles
            Benzene-soluble
            organic particles
                                                         /ig/m3
               Rank
          Mg/m3
                                       Rank
Chattanooga	
Chicago-Gary-Hammond-East Chicago	
Philadelphia	
St. Louis	
Canton	
Pittsburgh	
Indianapolis	
Wilmington	
Louisville	
Youngstown	
Denver	
Los Angeles-Long Beach	
Detroit	
Baltimore	
Birmingham	
Kansas City	
York	
New York-Jersey City-Newark-Passaic-Patterson-Clifton_
Akron	
Boston	
Cleveland	
Cincinnati	
Milwaukee	
Grand Rapids	
Nashville	
Syracuse	
Buffalo	
Reading	
Dayton	
Allentown-Bethlehem-Easton	
Columbus	
Memphis	
       180
       177
       170
       168
       165
       163
       158
       154
       152
       148
       147
       145.5
       143
       141
       141
       140
       140
       135
       134
       134
       134
       133
       133
       131
       128
       127
       126
       126
       123
       120.5
       113
       113
    1
    2
    3
    4
    5
    6
    7
    8
    9
   10
   11
   12
   13
   14.5
   14.5
   16.5
   16.5
   18
   20
   20
   20
   22.5
   22.5
   24
   25
   26
   27.5
   27.5
   29
   30
   31.5
   31.5
                                  14.5
                                  9.5
                                  10.7
                                  12.8
                                 12.
                                 10.
                                 12.
                                 10.
                                  9.6
                                 10.5
                                 11.7
                                 15.5
                                  8.4
                                 11.0
                                 10.9
                                  8.9
                                  8.1
                                 10.1
                                  8.3
                                 11.7
                                  8.3
                                  8.8
                                  7.4
                                  7.2
                                 11.9
                                  9.3
                                  6.0
                                  8.8
                                  7.5
                                  6.8
                                  7.5
                                  7.6
                                                                2
                                                               19.5
                                                               12.5
                                                                4
                                                                5
                                                               12.5
                                                                6
                                                               15
                                                               18
                                                               14
                                                                8.5
                                                                1
                                                               28
                                                               10
                                                               11
                                                               23
                                                               34
                                                               16
                                                               30.5
                                                                8.5
                                                               30.5
                                                               25
                                                               42
                                                               44.5
                                                                7
                                                               23
                                                               56
                                                               25
                                                               40.5
                                                               50
                                                               40.5
                                                               39
                                                                                          13

-------
 Table 1-2 (continued).-
-SUSPENDED PARTICLE CONCENTRATIONS (GEOMETRIC MEAN OF CENTER
     CITY STATION) IN URBAN AREAS, 1961 TO 1965.
          Standard metropolitan statistical area
                                     Total
                                suspended particles
        Benzene-soluble
        organic particles
                                                              Rank
                                                    Mg/m3
                 Rank
Portland (Oreg.)	
Providence	
Lancaster	
San Jose	
Toledo	
Hartford	
Washington	
Rochester	
Utica-Rome	
Houston	
Dallas	
Atlanta	
Richmond	
New Haven	
Wichita	
Bridgeport	
Flint	
Fort Worth	
New Orleans	
Worcester	
Albany-Schenectady-Troy _
Minneapolis-St. Paul	
San Diego	
San Francisco-Oakland	
Seattle	
Springfield-Holyoke	
Greensboro-High Point	
Miami	
                                   108
                                   108
                                   108
                                   105
                                   105
                                   104
                                   104
                                   103
                                   102
                                   101
                                    99
                                    98
                                    98
                                    97
                                    96
                                    93
                                    93
                                    93
                                    93
                                    93
                                    91.
                                    90
                                    89
                                    80
                                    77
                                    70
                                    60
                                    58
34
34
34
36.5
36.5
38.5
38.5
40
41
42
43
44.5
44.5
46
47
50
50
50
50
50
53
54
55
56
57
58
59
60
 9.5
17.7
 6.8
14.0
 5.6
 7.1
 9.4
 6.1
 7.0
 6.8
 8.8
 7.8
 8.3
 7.3
 5.2
 7.2
 5.3
 7.8
 9.7
 8.2
 6.6
 6.5
 8.5
 8.0
 8.3
 7.0
 6.3
 5.7
19.5
38
50
 3
58
46
21
55
47
50
25
36.5
30.5
43
60
44-5
59
36.5
17
33
52
53
27
35
30.5
47.5
54
57
out  the United  States.  For the most part,
measurements were taken at a single sam-
pling station in the downtown area  of  the
city.
   Based  on ten  years of sampling  at  ap-
proximately 370  sites, the highest  seasonal
average will exceed the  annual mean by 15
to 20 percent.  Seasonal averages for  the
high 2  percent of the sites exceeded the  an-
nual mean by 50 percent and the  lowest  2
percent exceeded the annual mean by about
5  percent.  Individual  24-hour  maximum
sample concentrations vary widely from  the
annual mean,  and on the average this vari-
ation is from 280 to 300 percent. Variations
as high as 700 percent of the annual mean
are  found for the  high  two percent  of  the
samples.   Sunday and holiday data are  us-
ually 15  to 20 percent below weekday con-
centrations. Table  1-3  shows  the relation
of population class of urban areas to particle
                            concentration  for  the  period  1958-1967,
                            while Table 1-4 shows the frequency distri-
                            bution of particle concentration in nonurban
                            areas for the same period.
                              Particle  concentrations  in  air have both
                            diurnal and annual  (seasonal)  cycles which
                            for  most cities are generally predictable in
                            shape.  A city with cold  winters will experi-
                            ence a seasonal maximum in  midwinter as
                            a result of  increased fuel use for space heat-
                            ing.  A  daily  maximum  in  the  morning,
                            probably between 6 and 8 o'clock, usually re-
                            lates to a combination of meteorological fac-
                            tors  and  an  increase in the strength  of
                            sources  of  particulates,  including the auto-
                            mobile traffic.
                              A  reflection of the effect of the strength of
                            various  sources  can also be seen in the pre-
                            viously mentioned lower weekend  and holi-
                            day versus  weekday concentrations.
                              In  cities where  photochemical  pollution
       14

-------
               Table 1-3.  DISTRIBUTION OF SELECTED CITIES  BY POPULATION
                     CLASS AND PARTICLE CONCENTRATION, 1957 TO 1967.
                                [Avg. particle concentration  A»g/m8]
Population class
>3 million
1-3 million
0 7—1 million
400-700,000
100^400,000 -
50-100,000- -
25-50,000
10-25,000
<10,000

Total urban

40
<40 to
59




3
2
5
7
1 5

1 22

60
to
79


1

7
20
24
18
7

77

80 1
to
99 :



4
30
28
12
19
15

108

LOO :
to
119 :


2
5
24
16
12
9
11

79

120 1
to
139 :



6
17
12
10
5
2

52

140 :
to
159 :
1
2
4
1
12
6
2
2
1

31

160 1
to
179 1

1 .

1
3
5
1
3
2

16

80
to :
99
1


1
2
1
?,
1


8

1
>200 (
in




1
3
3



7

fotal
:ities
table i:
2
3
7
18
99
93
71
64
44

401

Total
cities
n. U.S.A.
2
3
7
19
100
180

"5,453




    ' Incorporated and unincorporated areas with population over 2,500.
Table 1-4.—DISTRIBUTION OF SELECTED NON-
  URBAN  MONITORING SITES  BY  CATEGORY
  OF URBAN PROXIMITY, 1957 TO 1967.21


                    Average particle
   Category        concentrations, jug/m3    Total

               <20   20-39  40-59  60-79
Near urban •___ 	
Intermediate b
Remote ° 4

Total
nonurban 4
1
5
5

11
3
6


9
1 5
	 11
9

1 25
  a Near urban—although located in unsettled areas,
pollutant levels at these stations clearly indicate in-
fluence from nearby urban areas. All of these stations
are located near the northeast coast "population cor-
ridor."
  b Intermediate—distant  from large  urban  centers,
some agricultural activity, pollutant levels suggest that
some influence from human activity is possible.
  c Remote—minimum of human activity, negligible
agriculture, sites  are frequently in  state or national
forest preserve or park areas.

predominates,  the maximum  in concentra-
tion of particles in the range from 0.1/t to I/*
may come around noon,  after  the  sun has
had an opportunity to cause  photochemical
reaction.  Under these conditions, the highest
concentration  of  particles below O.I/*  will
come earlier, and there may be no clear trend
for larger particles.
  The above concentrations generally relate
to samples taken in the center-city commer-
cial district. This portion of the community
will generally not show annual average con-
centrations as high as those found in various
industrial  areas; however,  they  are  among
the  higher area concentrations  in a  com-
munity.  Annual concentrations in  nearby
suburban residential areas generally will be
about one-half of that found  in  center city.
   Particulate  air  pollution   is  not  only
source- and location-dependent  but  is also
a function of meteorological factors causing
a  variation in the natural  ventilation of a
community. Air pollution episodes are  char-
acterized  by minimum natural  ventilation,
and particulate concentrations at such  times
may  rise dramatically  as  indicated  by the
following examples:  during the  November-
December,  1962,  episode  in  the Eastern
United States, particulate concentrations in
several communities  rose  to two-to-three
times  normal; 22  during the  Thanksgiving
1966 episode, again  in the Eastern  United
States, particulate concentrations increased
by about a factor of two over mean autumn
levels.  In  fact, maximum  citywide average
concentrations in Philadelphia,  Worcester,
and  Boston exceeded maximum concentra-
tions recorded for an  autumn period  since
1961  at the National Air Surveillance Net-
work (NASN) stations.23
  Table 1-5 gives concentrations of certain
specific contaminants  found  in total  sus-
                                                                                 15

-------
 Table 1-5.  ARITHMETIC  MEAN AND MAXIMUM  URBAN PARTICULATE CONCENTRATIONS IN THE
                    UNITED STATES, BIWEEKLYY SAMPLINGS, 1960 TO 1965.18
                     Pollutant
    Number of
      stations
                                                                     Concentrations
                                                                 Arith. average '
               Maximum
Suspended particulates	
Fractions:
    Benzene-soluble organics_
    Nitrates	
    Sulfates	
    Ammonium	
    Antimony	
    Arsenic	
    Beryllium	
    Bismuth	
    Cadmium	
    Chromium	
    Cobalt	
    Copper	
    Iron	
    Lead	
    Manganese	
    Molybdenum	
    Nickel	
    Tin	
    Titanium	
    Vanadium	
    Zinc	
    Gross beta radioactivity..
             291  105
             218
              96
              96
              56
              35
             133
             100
              35
              35
             103
              35
             103
             104
             104
             103
              35
             103
              85
             104
              99
              99
             323
 6.8
 2.6
 10.6
 1.3
 0.001
 0.02
<0.0005
<0.0005
 0.002
 0.015
<0.0005
 0.09
 1.58
 0.79
 0.10
<0.005
 0.034
 0.02
 0.04
 0.050
 0.67
 (0.8 pCi/ms)
              1254
 39.7
101.2
 75.5
  0.160

  0.010
  0.064
  0.420
  0.330
  0.060
 10.00
 22.00
  8.60
  9.98
  0.78
  0.460
  0.50
  1.10
  2.200
 58.00
(12.4pCi/m3)
    a Arithmetic averages are presented to permit comparable expression of averages derived from quarterly com-
posite samples; as such they are not directly comparable to geometric means calculated for previous years' data. The
geometric mean for all urban stations during 1964-65 was SO yug/m3, for the nonurban stations, 28 /jg/m3.
    b No individual sample analyses performed.
pended participate matter. Certain sub-frac-
tional contaminants found in  total particu-
lates  may be related to community param-
eters; for example, average ambient  vana-
dium concentrations correlate  well  with the
kind of residual oil used, iron and manganese
correlate and  are attributed to their joint
emission from ferromanganese  blast fur-
naces, and annual gasoline sales correspond
with  the average lead fraction of suspended
particulates.   Similarly,  sulfates  correlate
with particulates in those communities which
derive  large  amounts  of  energy from  the
higher  sulfurous fuels.24
                2.  Dustfall
  Dustfall is the  usual  index of particles in
the size range greater  than 10/i, and it  has
mainly  been   reported   in short  tons  per
square  mile per month, arrived at by extra-
polation from  a jar a  few inches in  diam-
eter to  a square mile. Metric units are pref-
erable and the  current trend  is clearly in
their favor.  Typical  values for cities  are
0.35 to 3.5 mg/cm-'-month  (10 to 100 tons/
mile"-month),  while values  approaching 70
mg/cm2-month (2000 tons/mile2-month) have
been  measured  near  especially  offensive
sources.
   A search for  scientific interpretations or
correlations of dustfall data has been unsuc-
cessful.  There is no question that, within a
given city, dustfall  tends to increase with
the intensity  of human  activity.  Further-
more,  dustfall  measurements  are certainly
valuable in obtaining evidence against major
sources of dust.  However, trying to extract
detailed  information from small fluctuations
in dustfall appears to be an exercise in fu-
tility. Dustfall is complex, being affected by
the number of unvegetated  vacant  lots, ve-
hicular  traffic, uncontrolled  heavy industry,
and wind velocity. D:;sfiness of the environ-
       16

-------
 ment is an obvious nuisance  and a compo-
 nent of the economic  cost of pollution.

    F.   SAMPLING AND ANALYSIS  OF
      ATMOSPHERIC PARTICULATE
                 MATTER
      1.  Particles Larger Than 10/t
   Particles larger than 10/<, exist in the at-
 mosphere in very low numerical concentra-
 tions.   The  high  concentrations  that are
 sometimes found in ducts or in work spaces
 are the province  of industrial hygiene and
 are not considered here.
   Since the largest   particles  have  appre-
 ciable settling velocities and impact readily
 at low velocities, they  are usually determined
 gravimetrically following collection by depo-
 sition in a dustfall jar.23  Although a cylin-
 drical jar might  be expected to  collect the
 equivalent of the dust content of an air col-
 umn  of its own diameter extending  to the
 top of  the atmosphere,  in fact the aerody-
 namic effects of the jar edges, of the mount-
 ing  brackets  for  the  jar, and of adjacent
 structures tend to complicate the collection
 pattern. Only relative significance may be
 attached to the resulting data, and only then
 if conditions are carefully standardized.26-28
 (There is a legend of  a city which decreased
 its reported dustfall by half  in a single year
 by changing the height of its dustfall jars
 from 8 to 20 feet above ground level.)  There
 is no definitive  study  of the effect on meas-
 ured  dustfall  of the height  of the collector
 above ground.
   Gruber29 has successfully used an adhe-
 sive coating on the outside of cylindrical con-
 tainers  to ascertain the wind direction corre-
 sponding  to  maximum dust content of the
 air.  This  often permits identification of ma-
 jor dust sources. Evaluation  is visual. Euro-
 pean  practice favors  flat adhesive surfaces
 placed horizontally as  dust collectors.30 The
 advantages are not apparent, and analogous
 studies  using greased  microscope slides for
 pollen collection have shown  them  to  be
 highly variable in collection efficiency.31
  Cyclonic collectors have been employed in
combination with  high-volume samplers for
the selective sampling of  particles.32  While
 such collectors can remove virtually all parti-
 cles above 5/x, they also remove a significant
 amount of smaller particles. During an in-
 vestigation of atmospheric protein, a small
 cyclone separator was used ahead of a high-
 volume sampler. Particles exhausted through
 the cyclone outlet were collected on a filter of
 the high-volume sampler. The samples col-
 lected on  the filter of  the combination unit
 averaged about one-half  the weight of those
 collected at the same time on the filter of a
 high-volume  sampler with  no cyclone at-
 tached.
   A few studies 32~34 have used long horizon-
 tal tunnels as fractional  elutriators to deter-
 mine particle size distributions. The elutria-
 tor acts as  a prefilter for  the removal  of
 larger-sized particles in a manner similar to
 the cyclone  high-volume sampler  combina-
 tion. Both the cyclone and the elutriator, op-
 erating on aerodynamic principles, have  a
 graded selectivity (Figure 1-6) rather than
 a sharp cut-off point at a specific particle size.
 The size range  of the particles which pene-
 trate the elutriator but are  retained  on the
 filter at the outlet duct depends on the air-
 flow rate through the system  (Figure 1-6).
   Other methods for the  selective removal of
 larger  (nonrespirable) particles  have been
 described by Lippmann and Harris 36 and by
 Roesler.37
   The first stage of most cascade impactors 3S
 collects particles larger than about  5 to 10/u.
 Since, except in very dusty atmospheres, the
 mass mean diameter is smaller than this, col-
 lections on the first stage will be meager un-
 less the sampling time is set specifically  to
              AERODYNAMIC SIZE,/!

FIGURE  1-6. Horizontal  Elutriator Cut-off Charac-
  teristics.35 (This graph shows that  the elutriator
  collects  all particles  larger than 3%^ diameter
  when operated at 10 cfm, but at 50 cfm some par-
  ticles as large as 7^ diameter escape.)
                                                                               17

-------
give ample material. Adhesion of such large
particles is poor  (Section B-l),  so an ad-
hesive may be necessary to avoid bounce-off
or reentrainment.
  A variation is a  single-stage impactor with
size  discrimination developed  by  Dessens.39
He used a coarse  slit  followed by a shaped
channel  to  induce turbulent  deposition of
particles along  a  microscope  slide  with a
size  gradation from larger to smaller.
  It appears, therefore,  that no  presently
used technique for the concentration meas-
urement of particles larger than about 10/x is
superior to a properly installed dustfall jar;
this  method is also the least expensive. How-
ever, the jar  lacks time  resolution since it
must usually be exposed for two weeks to a
month to obtain a significant  sample. Dust-
fall jars should be more widely standardized,
and  more study  is  needed  of  alternative
means of sampling the largest particles in the
atmosphere. Chapter 11 shows some correla-
tions of health effects  with air pollution, us-
ing dustfall as an index of air pollution.
  Any  collection  technique  can  provide a
sample for subsequent analysis, although the
adhesives used in many of the methods de-
scribed can,  unless  carefully chosen, inter-
fere severely with  characterization of the
particles.  The  standard techniques used to
analyze  dustfall samples generally  reveal
which elements are somewhere in the sample
without giving any information as to which
particles  contain which  elements or  what
compounds these elements represent. Never-
theless, such  general  chemical composition
data are  often helpful. One simple type of
chemical  characterization which  gives this
sort of information for particles larger than
KV is morphological identification under the
microscope. Although this may be applied to
smaller particles as  well,  it is most effective
in the largest size range.  McCrone40 has
published a photomicrographic atlas of dust
components which should permit recognition
of up to 90 percent of the particles above 10/x
in a typical urban sample. In the hands of an
experienced microscopist, this  technique  is
one of the most potent tools in dust analysis.
X-ray diffraction  techniques  will  identify
chemical  compounds  present  rather than
merely the elements.
   Dustfall  levels have decreased  in most
cities  (Figure 1-7) and there is a  trend
 i-
 o
 O

 LU
     250 -
     200
     150
 DC
 LU
 >   100
      50
                   PITTSBURGH  ^	

               — — "*" CINCINNATI
                               CHICAGO
                                                                                    10
                                         I
                                         z
                                         O
                                                                                       !
                                                                                       EC
                                                                                       LU
        1935
                   1940
                                1945
                                             1950
                                                         1955
                                                                      1960
                                                                                  1965
 FIGURE 1-7. Dustfall Data for Six  Cities.  (This graph  is from a U.S.  Government publication, but
                             original source of the data is unknown.)
                                        the
       18

-------
 toward abandoning routine dustfall measure-
 ments, as they may no longer be indicative of
 pollution levels. This viewpoint is defensible,
 although, since excessive dustfall is one of
 the most noticeable  nuisances  consequent
 upon air pollution, there is public pressure to
 abate high dust emissions  (Chapter 7).

          2.  Particles  O.l^i  to  10/*
   A single group  of sampling and  analysis
 methods  generally serves for the size range
 from  O.lju to ID/*. This size range  includes
 both the bulk of the particulate mass and  a
 large  fraction of the numbers. The prepon-
 derant optical effects also arise from parti-
 cles in this portion of the size spectrum,  and
 most of the estimation methods  not involving
 collection are optical. Collection and analysis
 techniques in this size range have been re-
 viewed by Lodge41- *'-' and discussed  in  two
 chapters  of the 1968 treatise, Air Pollution,
 edited by Stern.43-44
   The simplest optical technique involves use
 of a photometer developed in its present form
 by Volz  4" for determining  air turbidity. A
 simple photocell is pointed at the sun through
 a series  of small apertures and a glass filter
 peaking at a wavelength of 500/x. An attached
 sight and spirit level allow  measurement of
 sun angle, which corrects the reading for air
 layer thickness  along the path between  the
 instrument and the sun.  A  nomogram may
 then be  used  to obtain the turbidity coeiffi-
 cient.  Greater accuracy,  if warranted, may
 be achieved by  using a computer; a simple
 program  has been developed for the calcula-
 tion.46 McCormick" found  that  turbidity
 measurements  from the   bottom and from
 the top of a high building  gave, by difference,
 a reasonable estimate of the concentration of
 the intervening particulate  matter.  This is
 the cheapest and simplest technique, although
 it cannot  measure continuously nor can it be
 used at night or during cloudy weather.
   Next in complexity is the "nephelometer"
 described by Charlson.48  This device meas-
 ures light scattered by particles suspended in
 a defined volume of air. It is illuminated by a
 flash tube placed so that nearly the total solid
 angle from full forward to direct back-scat-
tering occurs. Integral scattering is recorded
and, in the absence of a powerful nearby
 particle source, is very nearly a linear func-
 tion of mass concentration. A disadvantage
 of the method is that a constant particle-size
 distribution and composition  must  be as-
 sumed.
   Other light-scattering instruments include
 total  forward-scattering  and  right-angle-
 scattering  photometers as  well as  instru-
 ments which count and size individual parti-
 cles.49 The latter consist of:
     1.  A sampling system which dilutes the
        sample stream with purified air  until
        only one particle at a time is likely to
        be in the sensitive portion of the de-
        vice,
     2.  a light source and optics to illuminate
        a small volume (a  few mm3 at most)
        at a defined angle,
     3.  a phototube  (usually  a multiplier)
        sensitive enough to detect the indi-
        vidual  flashes of  light as particles
        pass the illuminated volume, and
     4.  a pulse height analyzer and counting
        electronics.
   A number of other principles for size an-
alysis  of particles without  collection were
surveyed during World War  II and the im-
mediate postwar years, but  none  seem  to
have warranted  commercial exploitation ex-
cept one device  to measure mobility in an
electric field. This latter technique is more
applicable to smaller particles and will be
discussed in  that  connection  (see Section
G-3).
   Cascade impactors 3S have  been found  to
be useful devices for simultaneously collect-
ing and classifying particles throughout most
of this size range, thereby yielding consider-
able information •r'°-"3 on  the  urban aerosol
size  distribution of selected  chemical com-
ponents  including  sulfate, lead,  and other
metals.  Similar  information  has  been  ob-
tained by use of a  helical-channel  centri-
fuge 54-56 as a classifier.
  Goetz •~>7 has described a  single-stage mov-
ing-slide impactor with some novel features.
It is  part of a system which includes mirror-
surfaced collecting slides and  incident dark-
field  microphotometry which is particularly
well  adapted to physical characterization of
particles from  roughly 0.2,*, to 2/*.  Informa-
                                                                               19

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tion on coalescence tendency and heat lability
is easily obtained.
  Spurny58 has studied the application  of
recently developed filter material to particle
research. The filter is a plane film of polycar-
bonate which is exposed to fission fragments
and then treated  to remove the radiation
damage. A number of pore sizes are avail-
able; the pores are uniform, straight, and cir-
cular in cross section. The plane upper sur-
face is ideal for both optical and electron mi-
croscopy  (the latter after replication), and
the filtration  characteristics  are excellent.
The uniformity of  the material commends its
use for gravimetric purposes  and for "smoke
shade"  determination. The only evident dis-
advantage at the moment is its price.
  Frank and Lodge 59 have described the use
of  electron microscopy  for  morphological
identification of several species of particles
smaller than I/*. Although the technique is
not so  broadly applicable as is optical mi-
croscopy of dusts, it may permit some an-
alyses, including the identification of sulfuric
acid droplets below I//,.
  In view of the extensive literature involv-
ing filter tape and  high-volume  samplers,
some further discussion of these devices is in
order,  especially since  air quality criteria
must ultimately relate to  accurate measure-
ments.  Both samplers are inexpensive and
durable, and both provide data which have
stringent limitations that are  not  always
understood.

a. Tape Samplers  for Suspended Particulate
   Matter
  The tape sampler most  widely used in the
United  States has  been the AISI (American
Iron and  Steel Institute)  sampler developed
by  Hemeon and his  colleagues.60 Other ver-
sions exist, but all are alike in function. A
series of portions of filter  paper, usually suc-
cessive  areas of a  paper tape, are positioned
so as to be clamped  between an intake tube
and a  vacuum  connection.  Air  is  drawn
through the filter for a selected time, usually
one to four hours,  and a new portion of tape
is then  moved into position and sampling is
resumed.
  The fundamental basis  of evaluating sam-
ples is  optical,  although   a  few nonoptical
methods have been studied. The visual color
of the spots may be compared with a stand-
ard gray scale. The reflectance may be meas-
ured photometrically. The transmittance of
light through both filter and deposit may be
compared with transmittance through a clean
portion  of  the filter. Visual and reflectance
measurements determine the blackness of the
deposit,  while  transmittance  measures a
function of all particles collected, and under
some circumstances measurements made by
the two techniques may not be identical. For
example, a gram of magnesium oxide smoke
collected in a single spot would not be visibly
gray and might even increase reflectance, but
would transmit no light at all. Urban particu-
late matter is not, however, pure magnesium
oxide, and, in fact, the three measures (vis-
ual, reflectance,  and transmittance)  gener-
ally correlate fairly well in the short run.
Over longer periods, the introduction of new
sources  and the  removal of old ones may be
expected to change the  composition of  the
particles enough to cause divergence of the
different techniques. For example, if a resi-
dential  area  abruptly  converts  from coal
heating to  gas, the virtual disappearance of
soot will have an enormous effect on reflect-
ance which may not appear so strikingly in
transmittance.
  Transmittance is by no means a  unique
function of the total concentration of partic-
ulate matter. Stalker et «L61 compared trans-
mittance and particle concentrations in  dif-
ferent  parts of  Nashville,  Tennessee. The
slopes of the regression lines varied by a fac-
tor greater than three, and at some locations
i o correlations appeared to exist between the
two measurements.
  Additional  complications  arise in  three
ways. First, none of the methods of measure-
ment  exhibit a  linear relationship between
the quantity determined and the number of
particles collected. Reflectance changes will
depend  on whether later deposits  are re-
tained on the surface of, or penetrate deeply
into, the layers first deposited. Measurements
of transmittance are similarly dependent on
whether an  added increment  simply adds
thickness to the collected deposit or fills pores
and gaps,  thus  increasing the bulk density
but not  the thickness of the layer.
       20

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   Second, the rate of sampling is not con-
stant but depends on the amount of material
already  collected and the structure of the
deposit.62 Hence the assumption of a constant
sampling rate will be seriously in error, es-
pecially for heavy deposits. Averaging initial
and final sampling rates, or recording the
sampling rate continuously,  represent im-
provements  at the cost of greatly increased
attention to the instrument,  or of increased
complexity and expense.
   Third, reflectance methods  lose all discrim-
ination beyond  a certain deposit  density.
Once the filter  is covered with  particulate
matter, only the exposed surface of the de-
posit affects  the reflectance;  the  reflectance
then become a measure of the composition,
but not the amount of material collected. This
problem is recognized,  but not solved, in  a
proposed European standard method.63
   Transmittance, which is most widely^ meas-
ured in the United States, is normally con-
verted into units of coh's per thousand linear
feet of air passing through  the  filter. Coh
stands for "coefficient of haze." A coh unit is
defined as that  quantity of  light-scattering
solids  (on the filter) which produces an opti-
cal density equivalent of 0.01 when measured
by light transmission. Optical density is de-
fined as the common (decadic) logarithm of
the opacity  (inverse of fractional transmis-
sion) .  Thus if one-fifth  of the incident light
is transmitted through the paper, as  com-
pared  with clean paper, the  opacity is five.
A coh measurement is  routinely  reduced to
coh  per 1,000 linear feet of air  passing
through the filter tape by dividing the unre-
duced coh value by the number of thousands
of feet actually drawn in the test.
   For  reflectance, a  RUDS test is made by
measuring the percentage reflectance of the
filter tape and similarly reducing the meas-
urement to 1,000 linear feet  of air.  Reflect-
ance of  clean paper  tape is  the  reference
standard, set at 100 on the reflectometer.
RUDS is an acronym for "reflectance unit of
dirt shade."
   Reflectance measurements are used in vari-
ous European countries for calculating am-
bient air concentrations of "smoke" or "dark
suspended matter." 63 The darkness  of the
filter stain is not considered proportional to
total particle concentration in the air but to
the  concentration of "dark suspended  mat-
ter" resulting  primarily from  combustion.
The darkness of the stain, as measured by a
reflectometer, is converted to surface concen-
tration of  smoke by means of a calibration
curve. The derived surface concentration is
then translated into an ambient concentra-
tion using  the relationship:
            SA
       C=	                   (1-2)
             V
where C = the concentration of smoke in the
           air (/xg/m3),
       S = the derived surface concentration
           (jug/cm2),
       A = the area of  the filter stain (cm2),
           and
       V = the volume  of  air sampled (m3).
  Experimental work on the form of the
calibration curve for  deriving surface  con-
centrations has been carried out in France,
the  Netherlands,  and  the United  Kingdom.
The Working Party on Methods of Measur-
ing Air Pollution and  Survey  Techniques of
the Organization  for Economic Cooperation
and Development has  proposed a Standard
International Calibration Curve  (the mean
of the curves developed in the three countries
listed above) as well as a standard sampling
and measurement procedure.63
  The use  of the conversion curves to make
international comparisons is potentially  dan-
gerous. The method has the disadvantage of
credibility; that is,  it is too  easy to overlook
the arbitrary nature of the units, and to be-
lieve that  actual airborne  particle concen-
trations have been measured. This is of  con-
cern for those areas of the United  States for
which air quality standards  already exist; in
most cases the standards include separate
values  for  "airborne particulate matter" ex-
pressed in gravimetric  units, and for "atmos-
pheric soiling"  determined by  transmittance
or reflectance measurements on deposits of
the sort described here.
  For  many  purposes,  the  International
Standard Calibration Curve will be found in-
convenient. It is the empirical product  of a
complex physical phenomenon  (light absorp-
tion and scattering) and an arbitrary instru-
ment response. The curve is  not  a mathe-
                                                                              21

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matical one, and hence computer reduction of
data is made awkward.
  Still other conversion formulae have been
suggested by Kemeny64 in South Africa, by
Ellison 65 in England, and by Sullivan ee  in
Australia. These workers, following Clark,67
have  attempted to  convert  their  readings
mathematically into units of milligrams per
cubic meter of "smoke" in the air. As Sander-
son and Katz 6S have correctly stated, "There
is considerable doubt whether a truly satis-
factory expression exists for the translation
of optical density readings into units related
to smoke and haze concentrations." The re-
sults of Stalker et al.,ei previously mentioned,
suggest that this may be an understatement.
The method yields only an index of and not a
measurement  of absolute concentrations  of
suspended particulate matter.
  Notwithstanding its limitations,  the tape
sampler is cheap, simple, and rugged, and it
will certainly  continue to be used. It should,
however, be used with the knowledge that its
measurements, in  whatever units,  are arbi-
trary and  artificial  and  without   absolute
meaning. Their relative values can  be useful
if the samplers, as well as  their locations,
their installation, and the technique of meas-
urement,  are  rigorously standardized. Fur-
thermore, it must be kept in mind that long-
term trends  may  reflect  changes   in com-
position  as well as in  amount of  airborne
particles.

6. High-Volume Samplers for Suspended
   Particulate Matter
  The original high-volume sampler  con-
sisted of the motor and blower of a tank-type
vacuum cleaner, suitably enclosed and fitted
with a holder for flat filter paper in place of
a dust bag. Present versions are  more re-
fined, but little different in concept. The use
of a blower necessitates a filter of large area1
and low air resistance, and  also makes  the
sampling rate very dependent on the mass of
material collected.
  Current samplers J9 are  generally exposed
inside a case  which places the filter surface
horizontal,  facing  upward, under a  roof
which keeps out rain and snow, and  generally
prevents collection of particles larger than
about 100/i. Filters are felts  of glass or syn-
thetic organic fiber. Since the fibers are sub-
stantially less than 1/j. in diameter, these fil-
ters  are highly efficient despite  their open
structure and consequent low resistance  to
airflow. Samples are normally collected for
24 hours and sampling rates are measured at
the beginning and end  of the period.
  Since the filters are weighed before use, it
is possible to determine the weight of col-
lected material if one standardizes the weigh-
ing conditions, optimally at 25 °C and at rela-
tive humidities below 50 percent. Thereafter,
samples  may be  extracted,  heated,  or in-
cinerated, and determination can  be made of
organic  content, carbon, minerals  or any
other suitable  and/or interesting fraction,
element, or substance. The collected sample
is the  particulate  content of approximately
2,000 m3 of  air,  and is large  enough for
nearly any sort of  analysis,  although care
must be used in interpreting the data. There
are a few studies on interactions between col-
lected species, loss through volatilization, and1
similar problems.  The performance charac-
teristics  of high-volume  samplers today are
quite well understood, though reactions  on
sampler filters are not.
  Many analyses are plagued by the lack of a
universally applicable filter material.  Glass
fiber filters are convenient for determining
total  particle concentration.  However, the
very fine glass fibers are water and acid sol-
uble,   and the  glass  contains   significant
amounts of a large number of metals, as well
as sulfate, silicate, and other anions. Hence
inorganic  analyses  are  performed  over  a
background from  the filter which-is by  no
means constant. Polystyrene fiber filters can
be made extremely low in inorganic  content,
but are virtually useless for organic analysis.
Membrane filters are very useful in special
applications,  e.g., when alkaline metals are to
be determined.
   Suspended particle concentrations,  deter-
mined  by high-volume  samplers in  urban
areas,  are shown  in  Table 1-2.  The column
listing "Benzene soluble organic particles" is
a measure of the organic particulate matter
in the  total sample. Much of this material is
derived  from the  incomplete combustion  of
fuels. The data on organics may be further.
analyzed for polycyclic aromatic hydrocarbon
       22

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content; a possible significance of these com-
pounds in carcinogenesis is discused in Chap-
ter 10.

     3.  Particles Smaller  Than  O.l/*

   Several techniques  have been  used sys-
tematically for the characterization of parti-
cles smaller than 0.1/t.
    1. Saturation of the air and subsequent
       rapid expansion to cause a high su-
       persaturation:  the resulting droplet
       count is assumed equal to the  total
       particle  concentration.  Successively
       smaller  degrees  of  supersaturation
       presumably activate only larger parti-
       cles to act as nuclei. Size spectra may
       be generated in this way, although the
       results do not necessarily agree with
       those of other  methods. Most of the
       available data were  obtained by this
       technique.69
    2. Passage of  the air  through  a  long
       narrow channel:  The smallest parti-
       cles will be removed most rapidly by
       diffusion, and the extend of the ef-
       fect can be  calculated.70 Differential
       condensation nuclei counts  after dif-
       ferent diffusion lengths permit deter-
       mination of a size spectrum.
    3. Measurement  of  the   mobility  of
       charged particles in  an electric field:
       It  is necessary to  assume or to  com-
       pute the efficiency of electrical charg-
       ing of these  smallest particles to de-
       rive numbers and  effective sizes. Orr
       and his coworkers 71 used this method
       to study changes in the size of hygro-
       scopic particles with relative humid-
       ity, and Whitby 72 has set up a facility
       for obtaining count-size distributions
       of  particles  in  air, using a series of
       instruments with overlapping ranges.
    4. Electron microscopic techniques  have
       been used to obtain particle counts as
       well  as  information  on the size and
       morphology  of  these small particles.

   Of these methods only the electrical mobil-
ity separator has been used n for chemical
characterization of  particles below O.lju, but
little analytical information is  now available.
The electron microscopic methods of Frank
and Lodge,59 and the earlier work of Tufts
and Lodge,73 provide some insight into the
chemical  composition of  the  particles,  al-
though even in the most favorable cases, the
authors were able to  account for the  com-
position of less than half of the particles
seen.


G.   SIZE, CHEMICAL COMPOSITION, AND
SOURCE  STRENGTHS  OF PARTICULATE
  MATTER FROM SELECTED EMISSION
                SOURCES

  A listing of source strengths  is given in
Table  1-6. Composition of particles  and,
where available, data on particle size distri-
bution from various sources follow.

        1.  Open-Hearth Furnaces

a. Chemical Composition
  Analysis 7* of particulate emissions from a
200-ton oxygen-lanced open-hearth furnace,
a composite sample for all process stages, in-
dicates the following chemical composition:
      Compound
       Fe,03
       FeO
       Si02
       A1203
       MnO
       Alkalis
       P205
       S
Percent
 89.1
  1.9
  0.9
  0.5
  0.6
  1.4
  0.5
  0.4
Fluorides may be present in open-hearth fur-
nace particulate emissions if fluorspar fluxes
or fluoride-containing  ores are used.  While
fluoride emissions are generally insignificant,
problems  have  been reported in the vicinity
of at least one plant  which uses fluorspar
fluxes and one which uses an ore with a high
fluoride content.75

b. Particle Size
  By number, the majority of particles emit-
ted by  an open-hearth  furnace are  below
O.lju, in diameter.76  Size analysis 74 of a com-
posite sample over  the  entire hearth indi-
cated the following distribution:
                                                                              23

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    Diameter
      (fj
        2
        5
       10
       20
       40
  Weight percent
less than stated size
       20
       46
       68
       85
       93
               2.   Incineration
a. Chemical Composition
  Analysis of emissions from municipal in-
cinerators in Los Angeles " indicated 20 per-
cent by weight of the discharge to be  con-
densable and approximately 5  to 15 percent
of the condensate to  be sulfuric acid.  The
remaining- 80 percent was particulate mat-
ter containing silicon, lead,  aluminum, cal-
cium,  iron, and traces of other elements.
   Particulate samples from the stack effluent
of  municipal incinerators  in   Milwaukee,78
ashed  and subjected  to spectographic  and
Table 1-6.—EMISSION FACTORS FOR SELECTED  CATEGORIES  OF  UNCONTROLLED SOURCES  OF
                                        PARTICULATES."
                Emission source
                                   Emission factor
Natural gas combustion:
    Power plants
    Industrial boilers
    Domestic and commercial furnaces
Distillate oil combustion:
    Industrial and  commercial  furnaces
    Domestic furnaces
Residual oil combustion:
    Power plants
    Industrial and commercial furnaces
Coal combustion:
    Cyclone furnaces
    Other pulverized coal-fired furnaces
    Spreader stokers
    Other stokers
Incineration:
    Municipal incinerator  (multiple chamber)
    Commercial  incinerator (multiple  chamber)
    Commercial  incinerator (single chamber)
    Flue-fed incinerator
    Domestic incinerator (gas-fired)
    Open burning of municipal refuse
Motor vehicles:
    Gasoline-powered engines
    Diesel-powered engines
Grey iron  cupola furnaces
Cement manufacturing
Kraft pulp mills:
    Smelt tank
    Lime  kiln
    Recovery furnaces b
Sulfuric acid manufacturing
Steel manufacturing:
    Open-hearth furnaces
    Electric arc  furnaces
                     15 Ib/million ft3 of gas burned
                     18 Ib/million ft3 of gas burned
                     19 Ib/million ft3 of gas burned

                     15 Ib/thousand gallons of oil burned
                      8 Ib/thousand gallons of oil burned

                     10 Ib/thousand gallons of oil burned
                     23 Ib/thousand gallons of oil burned

                     2X (ash percent) Ib/ton of coal burned
                     13-17X (ash percent) Ib/ton of coal burned
                     13X (ash percent) Ib/ton of coal burned
                     2-5X (ash percent) Ib/ton of coal burned

                     17 Ib/ton of refuse burned
                      3 Ib/ton of refuse burned
                     10 Ib/ton of refuse burned
                     28 Ib/ton of refuse burned
                     15 Ib/ton of refuse burned
                     16 Ib/ton of refuse burned

                      12 Ib/thousand gallons of gasoline burned
                     110 Ib/thousand gallons of diesel fuel burned
                     17.4 Ib/ton of metal charged
                     38 Ib/barrel of cement produced

                      20 Ib/ton of dried pulp produced
                      94 Ib/ton of dried pulp produced
                     150 Ib/ton of dried pulp produced
                     0.3-7.5 Ib. acid mist/ton of acid produced

                     1,5-20 Ib/ton of steel  produced
                     15 Ib/ton of metal charged
  a For more detailed data, consult "Control Techniques for Particulate Air Pollutants," U.S. Department of
Health, Education, and Welfare, Dec. 1968
  b With primary stack gas scrubber
        24

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wet chemistry analysis,  had the  following
composition:

      SPECTOGRAPHIC ANALYSIS
  Elements reported in percent of ashed material
       Element
       Calcium
       Silicon
       Sodium
       Nickel .
       Aluminum
       Zinc
       Magnesium
       Titanium
       Iron
       Barium
                              Percent
                               10 +
                                5 +
                               1-10
                               1-10
                               1-10
                               1-10
                               1-10
                             0.5-5.0
                             0.5-5.0
                             0.1-1.0
Small amounts (less than 1 percent) of man-
ganese, chromium, copper, vanadium, tin, sil-
ver, boron, beryllium, and lead were present.

      WET CHEMICAL ANALYSIS
       Phosphorus
       Silicate
       Phosphates
       Nitrates
       Sulfates
       Chlorides
                              Percent
                                1.46

                                0.88
                                0.62
                                5.0
                                0.02
  Analysis of fly ash collected at three New
York 79 incinerators and of that emitted from
their stacks showed the following chemical
composition:
                           Weight percent
                      Collected       Emitted
                        49.5
                        22.9
                         6.3
                         8.8
Silicon as Si02
Aluminum as A1203
Iron as Fe203
Calcium as CaO
Magnesium as MgO
Sodium as Na2O  1
Potassium as K2OJ
Titanium  as Ti02
Sulfur as  S03 .
                         2.2

                         6.0
                         1.3
                         3.0
36.3
25.7
 7.1
 8.8
 2.8
10.4
 0.9
 8.0
b. Particle Size
  Analysis of the particulate emissions from
the Los Angeles municipal incinerators in-
dicated 30 percent  (by weight) of the par-
ticles were less than 5/t in diameter. Particle
size analysis of the samples  collected at the
Milwaukee7S incinerators showed the  fol-
lowing distribution:
           Diameter
             (ft)
               5
              10
              20
              30
              44
                            Weight percent
                           less than stated size
                                 6.0
                                20.5
                                47.2
                                68.7
                                89.2
 3.  Sulfuric Acid Manufacture:  Chamber
                  Process

a. Chemical  Composition
   Acid mist  emissions contain sulfuric acid
and dissolved nitrogen oxides.  The nitrogen
oxides constitute  approximately 10 percent
by weight of total acid  mist emissions.

b. Particle Size
   The weight percentage of acid mist par-
ticles less than 3^i in diameter found in sam-
ples from two chamber acid plants, one using
molten dark  sulfur and  one  using solid sul-
fur, were  10.1 percent  and  3.5 percent re-
spectively.

  4.  Sulfuric Acid  Manufacture: Contact
                 Process so
a. Chemical  Composition
   Discharge  gases contain sulfuric acid mist
as well as unabsorbed sulfur trioxide, which
converts to acid mist upon reaching the at-
mosphere.  Trace  amounts of nitrogen ox-
ides may arise if  the fuel  used in the proc-
ess contains nitrogenous matter.

b. Particle Size
   In plants where particle size has been de-
termined, the weight percentage of particles
3//. or less  in diameter leaving the absorber
unit ahead of any mist  recovery equipment
ranged from  7.5 percent to 95  percent. The
mean percentage was 63.5.
  When  oleum is produced,  the proportion
of acid mist  particles smaller than 3/i in di-
ameter increases.  In one plant, the percent-
age rose from 9.5 percent to 54 percent.

           5.   Cement  Plants
a. Chemical Composition
  Chemical analysis  of  the  raw  kiln  feed
dust and the  kiln dust from the precipitator
outlet of portland cement plants in the Le-
                                                                              25

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high  Valley,  Pennsylvania,  region showed
the following composition:

                     Weight percent
Compound*
CaO
CaCO3
SiO,
A1203
Fe203
MgO
Na20
K20
MnO
Ti02
CuO
Ignition Loss
*No determination
Raw kiln
feed dust
(Average for
three types
of cement)

75.9
13.4
3.7
2.1






Dust from
precipitator
outlet (Average
of three
samples)
40.9

18.8
7.1
9.6
2.5
1.1
7.3
0.2
0.1
Trace
12.7
of sulfur made.
b.  Particle Size
  Examples of the  distribution  of  particle
sizes in cement plant raw kiln feed and kiln
emissions are indicated  below:

            Raw kiln feed      Kiln emissions
Diameter    weight percent     weight percent
  (tt)      less than stated size  less than stated size
              Ref. 81     Ref. 81 *      Ref. 1
60
50   .
40   .
30   .
20   .
10
 5
 2.5
  a Average of two samples

           6.   Motor Vehicles

a.  Chemical Composition
  Particles contained in vehicle exhaust in-
clude lead compounds, carbon particles, motor
oil, and nonvolatile reaction products formed
from motor oil in the combustion zone. The
reaction  products  include  high  molecular
weight  olefins, carbonyl compounds (alde-
hydes  and ketones), and free acids. Lead
particles in the exhaust are principally in the
from of PbClBr, the  <* and /3 forms of NH4C1.
81.4
73.1
63.8
53.3
41.5
23.5
10.8



96.5
92.9
84.6
56.3
15.5

97-100
95-100
85-95
70-90
50-70
30-55
20-40
10-35
2PbClBr and  2NH4C1 • PbClBr.  Particulates
discharged through  the blowby consist al-
most entirely  of unchanged lubricating oil.82
b. Particle Size
  Analysis83 of diluted exhaust from automo-
biles operated at crusing conditions showed
a particle  concentration of 40  to 52/ng per
liter of exhaust. From 62 to 80 percent of the
particulate mass consisted of particles  with
aerodynamic diameters below 2/j at unit den-
sity. The  lead content  of  particulate emis-
sions  averaged  about 40  percent and ap-
peared to  be  independent of particle  size.
Measurements S4 with undiluted auto exhaust
indicate that about 90 percent by weight of
exhaust lead  is  contained  in  particles  with
diameters below 0.5/i.

         7.  Fuel  Oil Combustion
a. Chemical Composition
  The probable constituents 85 of fly ash from
oil combustion have been identified as A1203,
A12(S04)3, CaO,  CaS04,  Fe203, Fe2(S04)3,
MgO,  MgS04,  NiO,  NiSO4  Si02, Na2S04,
NaHS04,   Na2S2O7,  V203,  V2O4.V2O5,  ZnO,
ZnS04, Na»C.V203> 2Na2O.V205,  3Na2O.V205,
2NiO.VL,05,  3NiO.V205,  Fe203.V203,  Fe203.
2V20,,  Na,O.V204.5V205   and  5Na20-V204.
HV20.,.
  Analysis 8e of fly ash from a plant using
residual oil produced the following percent-
age composition:






Element





Carbon
Ether Soluble
Ash (900°C)
Sulfates as S03
(Including H2S04)
Iron as Fe203
Nickel as NiO
Vanadium as V203
Silicon as Si02
Aluminum as A1203
Sodium as Na20
Test A Test B
Total solids Total solids
from burn- from burn-
ing PS 400 ing 4° API
oil (Col- oil (Col-
lected in a lected in a
laboratory glass
Electrical filter sock
precipitator at 300°F)
at230°F)
(Weight (Weight
percent) percent)
58.1a 18.1
2.3 4.4
17.4 51.2
17.5 25.0

3.1 3.7
1.8 13.2
2.5 4.7
0.6 9.7
1.6 14.9
0.9 3.0
a May include some hydrogen
       26

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  Less than  1  percent of the following ele-
ments or  compounds was present: Cl,  N03,
Cr02, Co203, BaO,  MgO,  PbO,  CaO,  CuO,
Ti02, Mo02,  B203,  Mn02, ZnO,  P205,  SrO,
TiO.

6. Particle Size
  A literature  survey8T of the size distribu-
tion of particles emitted by large oil-burning
units gave the following results:
          SIZE DISTRIBUTION
             (Percent by number)
0/j. to
            to 2
                   2to
                                 Largest size
48.4
64.2
93.5
94.8
28.8
18.8
3.2
2.2
16.7
10.0
2.0
1.5
6.1
7.0
1.3
1.0
15/i
15/i
20/i
20/x
  One reference indicated 47  percent, by
weight, was less than 3/i diameter.

        8.  Combustion of  Coal8S

a. Chemical Composition
  The following ranges in chemical composi-
tion were  indicated by analysis of fly ash
emissions from a variety of coal combustion
units.  The  figures are the  extreme values
 Particle Size
     (/i)
      10
      20
      40
      60
      80
     100
     200
             H.  SUMMARY
  Aerodispersed solid  and liquid particles
constitute a significant fraction of the pollut-
ants found in urban atmospheres. Such par-
ticulate matter vary greatly in chemical com-
position and consist of multimolecular assem-
blies that may range in complexity from salt
crystals and acid  droplets to  heterogeneous
liquid and solid aggregates and living cells.
In this document,  a particle is any dispersed
matter, solid or liquid, in which the indi-
WEIGHT PERCENT LESS THAN
Pulverized Fuel Cyclone
Fired Furnace Furnace
30 76
50 83
70 90
80 92
85 94
90 95
96 97
STATED SIZE
Spreader
Stoker-Fired
Furnace
10
20
37
47
54
60
—
found in four investigations,  each of which
reports wide ranges also.
                                 Percentage
Compound                          of fly ash
Carbon, C                        0.37-36.2 *
Iron (as Fe203 or Fe304)  .   .     2.0 -26.8
Magnesium (as MgO)            0.06-  4.77
Calcium  (as CaO)	    0.12-14.73
Aluminum (as A1203)             9.81-58.4
Sulfur (as SO,)                  0.12-24.33
Titanium  (as  TiOa)               0  -  2.8
Carbonate  (as CO3)     ,          0-2.6
Silicon (as  Si02)                17.3 -63.6
Phosphorus (as P2O5)          .   0.07-47.2
Potassium  (as KL,0)              2.8 -  3.0
Sodium (as Na20)                0.2 -  0.9
Undetermined                    0.08-18.9
  a Ignition loss
b. Particle Size
   Estimated particle size distributions 8S for
four  broad  classifications  of  combustion
equipment are listed below. All distributions
represent the size of the particles leaving the
boiler or furnace before  any control equip-
ment. The distributions reported for all four
equipment  classifications  ranged widely;
those shown  in the  table  are  considered
"typical."
                                                                             Stoker-Fired
                                                                             (Other-than
                                                                             Spreader)
                                                                                 7
                                                                                15
                                                                                26
                                                                                •36
                                                                                43
                                                                                50
                                                                                66
                                              vidual  aggregates  are  larger than  single
                                              molecules  (about 0.0002/*), but smaller than
                                              about 500/i diameter.
                                                Atmospheric particles have size-dependent
                                              dynamic, optical, and  electrical  properties,
                                              and are characterized by such surface activi-
                                              ties as sorption, nucleation, and adhesion.
                                              Particles in  the size range below O.I//, dis-
                                              play a  behavior similar  to that of molecules
                                              and are characterized by large random mo-
                                              tions caused by collisions with gas molecules.
                                                                               27

-------
In addition, they frequently collide with each
other and form larger aggregates. Particles
larger than I//, have significant settling veloci-
ties; their motions deviate from the motion
of the air in which they are borne, and their
rates of coagulation into larger aggregates
are low. The aerodynamic behavior of parti-
cles with diameters from 0.1/t to 1/t is transi-
tional between these two regimes.  Particles
larger than 10/* have rapid settling velocities
and therefore remain in the air for relatively
short durations. The size range between 0.1/t
and 10/t accounts for the bulk of the particu-
late mass in the atmosphere.
  Particles below 0.1/* obey the same laws of
light scattering as molecules  do and their ef-
fects on visibility are inconsequential. Parti-
cles very much larger than I//, obey the same
optical  laws  as macroscopic objects, inter-
cepting or scattering light roughly in propor-
tion  to  their  cross-sectional area.  Particles
between O.l/* and a few microns obey the very
complex scattering laws  set forth by  Mie.
This is the particle size range that is most ef-
fective in scattering light. (See Chapter 3.)
  Particles in the  atmosphere can be said to
originate by two types of mechanism. Small
particles in the size range below I/* arise prin-
cipally  by  condensation  and  combustion,
while the larger particles with the exception
of rain, snow, hail, and sleet,  result from
comminution.  Although the chemical compo-
sition of particles below O.I//,  diameter has
not been widely studied, the increase  over
natural levels of particles in this size range
seems to be entirely due to combustion. Com-
bustion products and photochemical aerosols
make up a large fraction of the  particles in
the range of 0.1-/x to I-/* diameter. Particles
between I/* and 10/i generally include  local
soil, fine dusts emitted by industry and,  at
maritime locations, airborne sea  salt. Indus-
trial  sources  of particulate  matter include
municipal incineration, cement  plants,  steel
mills, sulfuric acid manufacturing, industrial
furnaces, kraft pulp mills, and others. Parti-
cles  larger than 10/x diameter frequently re-
sult from mechanical processes such as high-
way  construction,  wind  erosion, grinding,
spraying, etc., and include material that is
dropped on the ground and pulverized by ve-
hicles and pedestrians.
  Dustfall measurements  provide  a rough
index of those particles which readily settle
out of the air. Typical values encountered in
urban areas range from 0.35 mg/cm2-month
to 3.5 mg/cm2-month (10 tons/mi2-month to
100 tons/mi2-month) while values approach-
ing 70 mg/cm2-month (2000 tons/mi2-month)
have  been measured close to very severe
sources.  Levels of dustfall have  apparently
declined  in cities, and dustfall measurement
is probably not useful as an index of overall
particulate levels.  Nevertheless,  dustfall  it-
self constitutes a nuisance, and its measure-
ment  provides  some  indication  of urban
dirtiness.
  A number of  methods are available  to
measure the mass concentration of suspended
particles. Optical techniques, such as the sun
photometer, the  integrating  nephelometer,
and light-scattering counters,  provide an in-
dication of particle concentrations in the size
range from 0.1/* to 10/*. Two of the most com-
mon instruments for measuring mass con-
centrations are spot samplers and  high-vol-
ume samplers.  In  the former, air is drawn
through  an exposed portion of a paper tape;
then  the tape  is moved  to expose  another
spot.  The spots that result on the tape are
evaluated optically by measuring their  light
reflectance or transmittance.  Although the
spot sampler is cheap, simple, and rugged,  its
use is better suited to the determination  of
relative  rather than  absolute mass concen-
trations. High-volume  samplers employ  a
blower  which sends  air  through a special
filter  over a specified time period. By weigh-
ing the material collected by the filter, the
mass  concentration  can  be   readily deter-
mined; chemical analyses also  can be carried
out. High-volume sampling is  the method  of
choice for measuring particulate levels. As
with  any other point-sampling method, the
location  of the sampling instrument is very
critical, and data for an entire  city should not
be  based on a single sample located  at a
single place.
  Most of the data on suspended particulates
come  from the National Air Surveillance Net-
work  (NASN), which employs the high-vol-
ume sampler. NASN currently  consists  of
about 200 urban and 30 nonurban stations,
and it is supplemented  by State and  local
       28

-------
networks. Based on these data, annual geo-
metric  mean  concentrations  of  suspended
particulate  matter range from  60 jug/m3  to
about 200 /xg/m3 in urban areas.  The maxi-
mum  average   concentrations   for  24-hour
periods is about  3 times the annual mean
with values of 7 times the mean occurring in
about 2 percent of the communities. In gen-
eral, mean  particulate concentrations  corre-
late with urban  population class, but there is
a wide  range of concentrations within each
urban  population  class,  and many smaller
communities have higher concentrations than
larger  ones. In nonurban areas, typical geo-
metric mean concentrations  range between
10 /xg/m3 and 60
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        30

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60. Hemeon, W.  C.  L., Haines,  G.  F., Jr.,  and  Ide,
    H. M. "Determination of Haze and Smoke Con-
    centration by Filter Paper  Samplers." Air Re-
    pair, Vol. 3, pp.  22-28, 1953.
61. Stalker, W. W., Dickerson,  R.  C., and  Kramer,
    G. D.  "Atmospheric Sulfur Dioxide and Particu-
    late Matter, a Comparison of Methods of Meas-
    urement."  Am. Ind. Hyg. Assoc. J., Vol. 24, pp.
    68-79, 1963.
62. Park,  J. C., Keagy, D. M.,  and Stalker, W. W.
    "Developments in the Use of the A. I. S. I. Auto-
    matic  Smoke Sampler." J. Air Pollution Control
    Assoc., Vol. 10, pp. 303-306, 1960.
63. "Methods of Measuring Air  Pollution. Report of
    the  Working Party  on  Methods of  Measuring
    Air Pollution and Survey Techniques." Organi-
    zation for  Economic Cooperation  and Develop-
    ment,  Paris, France, 1964, 94 pp.
64. Kemeny, E.  "The Determination of Gravimetric
    Pollution  Concentrations by  Means of  Filter
    Paper." J. Air Pollution  Control Assoc., Vol. 12,
    pp. 278-281, 1962.
65. Ellison, J.  M. "Die Schatzung der Konzentration
    teilchenformiger  Luftverunreinigungen  durch
    Bestimmung des Verschmutzungsgrades von Fil-
    tertapieren."  Staub, Vol.  28,  pp. 240-246, 1968.
66. Sullivan, J.  L. "The  Calibration of Smoke Den-
    sity."  J. Air Pollution Control Assoc., Vol. 12,
    pp. 474-478, 1962.
67. Clark, J. G. "Calibration  of  Dr. Owen's Appara-
    tus for the  Estimation of Suspended Solid Pollu-
    tion in the  Atmosphere. Report on Observations
    in the  Year  1966-67." Advisory Committee on
    Air Pollution.
68. Sanderson,  H. P.  and Katz, M. "The Optical
    Evaluation  of Smokes or  Particulate Matter  Col-
    lected  on Filter Paper." J.  Air Pollution Con-
    trol Assoc.,  Vol. 13, pp. 476-482, 1963.
69. Rich, T. A., Pollak, L.  W., and Metnieks, A. L.
    "Estimation of Average Size of Submicron Par-
    ticles from the Number  of  All and Uncharged
    Particles." Geofis. Pura Appl., Vol. 44, pp. 233-
    241, 1959.
70. Megaw, W. J. "Recent Research on Small Ions
     and Aitken  Nuclei." J.  Rech.  Atmospheriques,
    Vol. 2, pp. 53-68, 1966.
71. Orr, C., Kurd, F. K., Hendrix, W. P., and Junge,
    C.  E.  "The  Behavior  of Condensation Nuclei
    under  Changing  Humidities." J. Meteorol., Vol.
    15, pp. 240-242, 1958.
72. Whitby, K. T. and Clark, W. E. "Electric Aero-
    sol  Particle  Connecting and  Size Distribution
    Measuring System  for  the 0.015 to  lju  Size
    Range." Tellus,  Vol. 18, pp. 573-586,  1966.
73. Tufts, B. J. and Lodge, J. P. "Chemical Identifi-
    cation of Halide and Sulfate in Submicron Par-
    ticles." Anal. Chem., Vol. 30, pp. 300-303, 1958.
74. Strauss, W.  "Cleaning Waste Gases from Open
    Hearth  Steel  Processes." Chem. Process  Eng.,
    Vol. 41, pp. 339-343, 331, 1960.
75. Purvance, W. T.  "Atmospheric  Pollution Con-
    trol."  Chem.  Process Eng.,  Vol.  55,  pp.  49-53,
    1959.
76. Silverman, L. "Technical Aspects of High Tem-
    perature Gas Cleaning for  Steel Making Proc-
    esses." Air Repair, Vol. 4, pp. 189-196, 321, 1955.
77. Chass,  R.  L.  and Rose, A. H.  "Discharge from
    Municipal Incinerators."  Preprint.  (Presented
    at the 46th Annual Meeting, Air Pollution Con-
    trol Association, 1953.)
78. Jens, W. and Rehm, F.  R.  "Municipal Inciner-
    ation  and  Air  Pollution  Control."   Preprint.
    (Presented at  the  National  Incinerator  Con-
    ference, American Society of  Mechanical Engi-
    neers, New York, May  20-24, 1966.)
79. Kaiser, E. R. "Refuse Composition and Flue Gas
    Analyses  from  Municipal Incinerators." Proc.
    Natl. Incinerator Conf., American Society of Me-
    chanical Engineers, 1964. pp. 35-51.
80. "Atmospheric  Emissions from  Sulfuric  Acid
    Manufacturing Processes. A  Cooperative  Study
    Project of the Manufacturing Chemists' Associa-
    tion, Inc." U.S. Dept. of Health, Education, and
    Welfare, Div. of Air Pollution,  Cincinnati, Ohio,
    PHS-Pub-999-AP-13, 1965.
81. Doherty, R. E. "Current Status and Future Pros-
    pects, Cement Mill Air Pollution Control." Proc.
    Natl.  Conf.  Air Pollution, Washington,  D.C.,
    1966, pp. 242-249.
82. "Motor Vehicles,  Air Pollution, and Health. A
    report of the Surgeon  General  to the U.S. Con-
    gress."  U.S.  Dept.  of Health, Education,  and
    Welfare, National Center for Air Pollution Con-
    trol, Washington, D.C.  1962.
83. Mueller, P. K.,  Helwig,  H.  L., Alcocer, A. E.,
    Gong, W. K.,  and Jones E. E. "Concentration of
    Fine Particles and Lead in Car Exhaust." Amer-
    ican  Society  for  Testing and  Materials, Spec.
    Tech. Pub. 352, 1964, pp.  60-73.
84. Lee, R. E., Jr., Patterson, R. K.,  Crider, W. L.,
    and  Wagman, J. "Concentration  and Particle
    Size  Distribution of  Particulate Emissions in
    Auto Exhaust."  1968.  (Manuscript in  Prepara-
    tion) .
85. Bowden, A. T.. Draper,  P., and Rowling, H. "The
    Problem of Fuel  Oil Deposition in Open Cycle
    Gas  Turbines." Am. Inst. Mech. Engrs.  Proc.,
    Vol.  167, pp. 291-300, 1953.
86. MacPhee, R. D., Taylor, J. R., and Chaney, A. L.
    "Some Data on  Particles from Fuel  Oil  Burn-
                                                                                            31

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   ing." Air Pollution Control District, Air Analysis        nati, Ohio, PHS-Pub-999-AP-2, November 1962.
   Division, Los Angeles, California, Analysis Paper     88. Smith, W. S.  and Gruber, C. W.  "Atmospheric
   7, November 18, 1957.                                Emissions  from Coal Combustion.  An Inventory
87. Smith, W.  S. "Atmospheric Emissions from Fuel        Guide." U.S.  Dept.  of  Health,  Education,  and
   Oil Combustion." U.S. Dept. of Health, Educa-        Welfare, Div.  of Air Pollution, Cincinnati, Ohio,
   tion,  and Welfare, Div. of  Air Pollution, Cincin-        PHS-Pub-999-AP-24, April  1966.
        32

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                   Chapter 2
EFFECTS OF ATMOSPHERIC PARTICULATE MATTER ON
         SOLAR RADIATION AND CLIMATE
              NEAR  THE GROUND

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                         Table of Contents
                                                                      Page
 A. INTRODUCTION                                     	     35
 B. EFFECTS OF PARTICULATE MATTER IN THE ATMOSPHERE
    ON VISIBLE RADIATION                     	    35

 C. EFFECTS OF PARTICULATE MATTER IN THE ATMOSPHERE
    ON TOTAL SOLAR RADIATION                               .    38
    1. Physical Factors                                          ...    38
    2. Seasonal Variations                                        .  .    39
    3. Weekly Variations                                 	      39
    4. Other Variations                                       .          40
 D. INFLUENCE  ON  PRECIPITATION                                40
 E. RELATION TO WORLDWIDE CLIMATE CHANGE                   42

 F. SUMMARY                                                       43

 G. REFERENCES                                           .         44

                          List of Figures
 Figure
 2-1   Relation of Solar Transmissivity to Height Above Ground in "Pol-
       luted" and "Clean" Areas           .      	    36
 2-2   Annual  Variation of the Ratio of Illumination Levels in Central Lon-
       don and at Kew  (•), and of Concentration of Particulate matter at
       kew (o)                                                   .     37
 2-3   Causes  of Cyclical Diurnal Smoke Variations                        41
 2-4   Yearly Cycle (Averaged Over Six Years) of Deposited Pollutants       41
 2-5   Precipitation Values at Selected Indiana Stations and  Smoke-Haze
       Days at Chicago             .                                     42

                           List of Tables
 Table
 2-1   Approximate Association  Between  Atmospheric Aerosol Concentra-
       tions and Relative Solar Radiation Levels                           39
 2-2   Loss  of Sun's Radiation in Three European Cities Over That in the
       Adjacent Country              .                   ....      40
 2-3   Mean Number of Condensation Nuclei for Various Ranges of Dust
       Concentrations in City Air               ...            .       .40
34

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                                     Chapter  2

EFFECTS OF ATMOSPHERIC PARTICULATE MATTER ON SOLAR RADIATION
                         AND  CLIMATE NEAR  THE  GROUND
           A.  INTRODUCTION

  Particles in the atmosphere play several
roles  in the behavior and  determination of
the weather. Among the most obvious is the
effect they have on  the radiation from the
sun. They scatter the light to greater or lesser
extents in different wavelength regions, de-
pending on their size, character, and concen-
tration,  and thus  provide  the sky with  its
variable hues, its colorful dawns and sunsets,
and also  dense hazes and  dark urban palls.
More subtle changes  are occasioned by parti-
cles when they reduce the amount of solar en-
ergy that reaches the ground.
  Particles play a less  advertised but very
essential  role  in  the formation  of clouds.
Without them, liquid water clouds could not
form  except at supersaturations  of several
hundred percent. However, the sort of parti-
cles required (called condensation nuclei) are
provided  in overabundance by natural proc-
esses. Only to the extent  that higher-than-
normal nuclei concentrations can affect the
cloud-forming process, does man's introduc-
tion of additional  particulate material into
the atmosphere produce  changes in observed
cloud structure and  occurrence.
  The kinds of particles  which cause precipi-
tation from clouds, in contrast to those neces-
sary for  cloud formation,  are frequently in
short supply  in the atmosphere.  In warm
(above freezing) clouds, the  requirement is
a wide distribution  of condensation nuclei,
some of which are giant hygroscopic nuclei
larger than 1/x. These "giants" promote the
rapid growth of cloud droplets by producing
some droplets  large  enough to fall with re-
spect  to the others.  These grow rapidly  by
sweeping up smaller  drops and very soon be-
come massive enough to fall from the base of
the cloud as rain.
  Another kind of particle  is required to
stimulate  the rapid transformation of cloud
droplets  into  precipitation  in supercooled
(subfreezing)  parts of clouds. Such particles
are  termed freezing nuclei. Without  these,
the water  droplets would not freeze except
at temperatures below — 40°C. Once frozen,
small ice  particles grow rapidly at the ex-
pense of the surrounding water droplets and
begin to fall as snow. They may later melt to
become rain.  Dramatic  changes  in  cloud
structure have been achieved by seeding su-
persaturated clouds with appropriate  freez-
ing nuclei. There is evidence, discussed below,
that some observed changes in precipitation
patterns in a few sections of the country can
be  ascribed to the inadvertent  seeding of
clouds by industrial contaminants.
  Finally, tentative as our current informa-
tion and  understanding  may  be,  the long-
range potential  effect  of  adding  more  and
more particles to the  atmosphere cannot be
ignored. As more is learned about the general
circulation of the atmosphere and the deli-
cate balance between incoming and outgoing
radiation  (the "throttle on the atmospheric
engine"), it seems increasingly possible that
small changes such as those occasioned by in-
creasing  particle loads in the atmosphere
may produce very long-term  meteorological
effects.

B.   EFFECTS OF PARTICULATE MATTER
  IN THE ATMOSPHERE ON VISIBLE
               RADIATION
  Stable particles of negligible fall velocity
are probably the most common and persistent
air pollutants. Their optical effects in produc-
                                                                             35

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                        WJLHOI3H
                                                                            VI
                                                                            g
                                                                            •
36

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ing haziness,  atmospheric turbidity, and a
reduction of visibility which  hampers the
safe operation of aircraft and motor vehicles,
are well  known. (See Chapter  3.) The  solar
radiation transmissivity (![A]/!O[A] where
I [A.] is the intensity of the normal-incidence
solar radiation and IO[A] is the extra-terres-
trial value at this  wavelength) varies  with
height and is strongly influenced by the dust
loading in the lower atmosphere.1 Figure 2-1
illustrates  the  relation of  transmissivity at
A = 5000 A to height in the atmosphere above
an urban area under  varying  conditions of
particulate loading. In the case of heavily
polluted air, this radiation may be reduced by
more than one-half in the lowest 300 meters
of the atmosphere. There is also an increased
attenuation of  visible radiation  near the
ground in  clean air but the amount is  small
by comparison (Figure 2-1).
  It is well known that the reduction or at-
tenuation of visible radiation  in industrial-
ized urban areas, and the attendant gloom
caused by excessive  concentrations of sus-
pended particles in the air,  create a  need
for additional  artificial illumination in  of-
fices,  factories, and homes,  and  produces
added economic stresses. This is particularly
true in winter, when the  days are shorter
and  the particulate  content  of the urban
air is greater because  of greater combustion
of fuels.  Data given by Shepherd 1 illustrate
some relationship, shown in Figure 2-2, be-
tween  particle  concentrations and relative
visible radiation  levels in London  during
summer  and winter months. Daylight illumi-
nation was measured at two sites, one in cen-
tral London, the other in Kew Observatory, a
slightly  less  heavily polluted  area 13  miles
WSW  of the first site. As another example,
the average  loss of sunlight  in  the  city of
Leningrad compared to the countryside was
estimated to be 40 percent over the period of
a year; in winter the loss was estimated to
reach 70 percent in the city, while in summer
the loss was about 10 percent.3
  Haze in the atmosphere due to forest  fires,
dust storms, or smoke from  other sources,
may become so concentrated  at times that
the sun  appears red in the sky despite the
absence of clouds. Just after sunrise or just
before sunset,  the  haze may reduce the  in-
               VISIBLE RADIATION
                 LONDON/KEW
                         o   o
                M

             PARTICULATE LOADING
                AT KEW, mg/m3
FIGURE 2-2.  Annual Variation of the Ratio of Visi-
  ble Radiation Levels in  Central  London  and  at
  Kew  (•), and of Concentration of Particulate
  Matter at Kew (o) *  (This figure  indicates  the
  relative attenuation of light at two sites in a large
  city.)
tensity of the direct sunlight so much that
one can look directly at the sun without eye
strain  or injury.  In  other words,  haze in
the atmosphere due  to suspended particles
scatters  the  light from the sun, making  it
appear dim.
  Scattering of the sunlight by the particles
makes  the air seem "turbid," and an optical
device  called the  Volz sun photometer has
been devised to  measure this  "turbidity"
quantitatively.4  Starting with equations 3-2
in Chapter  3 (Lambert's  Law), one calcu-
lates from the readings of this  instrument
a "turbidity coefficient,"  B, related to the
extinction coefficient b in equation 3-2, Chap-
ter 3,  or more specifically to bscat  defined
there.  The  relationship between B and  b
is outlined by McCormick  and Baulch,2 who
found that in a city Bz, the value of B meas-
ured by  the Volz  instrument at a height of
z meters above the ground, is related to B0,
the value of  B measured near ground level,
by the  equation
              Bz=B0e-°-00346z          (2-1)
                                                                               37

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  From  scattering theory,  McCormick  and
Baulch estimate that at any height, z, up to
200 meters above the ground, the number of
particles per cubic meter, n' (z),  in the ra-
dius range between 0.7/* and 1/x is given by
       n'(z)=17.3xl09B0e-°-00346z  .   (2-2)
  Both of these equations are rough approxi-
mations  for light-wind, clear-sky conditions
in a city during  moderate to heavy  pollu-
tion situations.  In terms of mass loading
near the ground,   [m'  (o)],
          m'(o)«a03B0 Ugm-3)       (2-3)
C.  EFFECTS OF PARTICULATE MATTER
    IN THE ATMOSPHERE  ON TOTAL
           SOLAR RADIATION

  Landsberg 5 reports that cities in general
receive 15  percent to 20 percent less insola-
tion (on a  horizontal surface)  than do their
rural  environs.  Insolation,  as used here,
means the  total solar radiation received at
the earth's surface  per unit area per unit
time. This discussion considers the part that
airborne particles take in  the diminution of
insolation received by cities.

           1.  Physical Factors
  The attenuation of solar radiation through
the atmosphere is  caused by  a number of
physical factors: -• 6-10
     1. Scattering of  radiation, known  as
       Rayleigh scattering, by the air mole-
       cules, such as  N2  and  O,,  and par-
       ticles in  size ranges less  than  the
       wavelength   of  the  solar   radiation
        (the scattering coefficient is inversely
       proportional  to  the fourth  power of
       the wavelength of the  incident ra-
       diation; hence  the short wavelength
       radiation  is  scattered most, so that
       the sky appears to be blue) ;
     2. Selective  absorption  by the gaseous
       constituents  of  the atmosphere such
       as ozone and C02,  and by  water va-
       por; and
     3.  Scattering and absorption  by atmos-
       pheric dusts and  particulate matter
       of size greater than in (a) .
  The attenuation of solar radiation by wa-
 ter vapor and ozone is negligible in the visible
 wavelength  region  usually  studied.6-T- "
   The scattering of light by aerosol particles
 in ambient air is a complicated process. Part
 of the incident light is transmitted, part is
 reflected in all directions either at the front
 surface of the particle or at an internal dis-
 continuity, and part is absorbed.  The trans-
 mission  factor for scattering is  a function
 of the wavelength of the incident light and
 the  physical qualities of the scattering me-
 dium. In simple cases  where the form, size,
 and composition of the scattering particles
 are  known,  the factor can  be derived on a
 theoretical basis and is known as "Mie" scat-
 tering. Chapter 3 provides  a more extended
 discussion.
   Diffuse  radiation  is an  important factor
 in the amount of heat and  light received at
 any  given location.3-10 The intensity  and
 spectral distribution of direct sunlight and
 scattered daylight, and the varation of in-
 tensity with time of  day,  season, latitude,
 altitude, and atmospheric conditions such as
 turbidity,  are  important because they affect
 photosynthesis  in  plants  and the distribu-
 tion  of  plants and  animals on earth,  the
 weathering  of  natural and man-made ma-
 terials, climate, and  illumination for human
 activity.9 The percentage of direct solar ra-
 diation which  will remain after its attenua-
 tion  by smoke and  other atmospheric  con-
Xtituents depends  both on  the atmospheric
 turbidity caused by  the smoke,  and on  the
 altitude of the sun above the horizon, as well
 as on the other factors 3 previously noted.
   Except in cases of heavy particulate pollu-
 tion  of the  atmosphere, such as may occur
 in large urban  centers or heavy industry
 areas, it appears that the effect of turbidity
 is to scatter radiation out of the direct solar
 beam and to add an  almost equal amount of
 radiation to the diffuse beam arriving from
 the  rest  of  the sky by forward-scattering.
 In cases of heavy particle concentrations,
 however, the loss from the  direct solar beam
 greatly  exceeds  the  gain in the downward
 scattered beam, the  difference being lost to
 back-scattering off the top of the pollution
 layer and to absorption within  the polluted
 layer or column.
   Studies indicate a  fair approximation of
       38

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the association between atmospheric aerosol
concentration and  relative  solar  radiation
levels, as shown in Table 2-1.

Table  2-1.—APPROXIMATE  ASSOCIATION  BE
   TWEEN ATMOSPHERIC AEROSOL CONCEN-
   TRATIONS AND RELATIVE SOLAR RADIA-
   TION LEVELS.

                     Solar radiation, percent of
Aerosol concentration,

       tig ni-3
value for 100 ^.g m-3
 Total   Ultraviolet
50
100
200
400
105
100
95
90
104
100
92
77
  The reduction in ultraviolet light reaching
the surface may be  as important as  the at-
tenuation of other, longer wave, components
of solar radiation. Available data are sparse
but one study12 indicates that ultraviolet in-
tensity decreased by about 7.5 percent for
each  100 jug/m-3 increase in aerosol con-
tent of the  atmosphere with an average de-
ficiency of over 20 percent in the city as com-
pared  with its environs in winter.  Some
studies suggest that a  5 percent reduction
in total solar radiation resulting from smoke
almost completely eliminates the ultraviolet
component.3-12   Even in  a  comparatively
clean  atmosphere, the  effective ultraviolet
drops to very low values when the sun's ele-
vation is below 30 degrees.13
  The net influence of atmospheric turbidity
on surface temperature is uncertain, but for
typical turbidity indices in the United States,
it is likely to be small.  The effect on  solar
radiation (warming in  the upper region  of
the pollution layer due  to  extinction  by the
upper  region)  tends to  be compensated by
the effect on radiation  returning to space
from  the earth's surface  and  atmosphere.
The extent to which the solar radiation effect
prevails  over the terrestrial radiation effect,
or vice versa, is dependent on a number  of
factors which include:
    1. the time of day  and year (on which
       the intensity of  solar radiation  is it-
       self dependent);
    2. the total mass and vertical distribu-
       tion of the particles;
     3. the size distribution of the particles;
     4. relative humidity, which, in the case
       of hygroscopic  aerosols, may alter
       the effective absorptivity and reflec-
       tivity of the particles; and
     5. temperature of  the air and ground
       (on which the intensity of the terres-
       trial radiation depends).

          2.   Seasonal  Variations

  The concentration of suspended particu-
late matter which ranges from less than 60
jug/m3 to 1700 /ig/m3 in various American
cities  shows  a  notable  annual  variation.
Autumn  and winter particulate levels are in-
variably  highest, and summer levels  lowest.
The weakening of radiation caused by smoke
is less during the summer when the sun is
high  than in the  winter. This  would  be
true even if there were the same degree of
pollution in the air. The losses in intensity
of direct total solar radiation during its pas-
sage  through  an  atmosphere  polluted  by
smoke may  become as  high as one-third in
the summer and two-thirds in the winter.3
  Landsberg5 has summarized the radiation
loss data compiled by Steinhauser 13 for three
Central  European  cities—Frankfurt, Leip-
zig, Vienna—and their adjacent rural areas,
for the four seasons of the year. There are
contrasts in loss  of solar radiation between
spring or summer and winter, as will be
seen  in  Table  2-2. Steinhauser  and  co-
workers " also reported that Vienna receives
a lesser total radiation than the nearby coun-
tryside:  in  winter 85  percent  of the total
solar radiation of  suburban  Hoche  Warte,
in spring 92 percent, in summer 92 percent,
and in autumn 87  percent.R-13  The absorp-
tion is strongest in the short (ultraviolet)
wavelengths.s- "• "•14
  This annual cycle is observed to be a func-
tion of latitude, dependent on the changing
midday sun angle.  The scattered radiation
during the summer months  (May-August)
may amount to approximately 60 percent to
65 percent of the direct radiation at 60° lati-
tude and to about 45 percent at 40° latitude.

          3.   Weekly Variations
  In  addition to the seasonal  and diurnal
variations or  patterns  of  total solar radia-
                                                                              39

-------
tion in  urban communities,  a weekly cycle
of intensity of total solar radiation has been
observed,15^17 which is related to the weekly
cycle of industrial and commercial  activity.
In general, the total solar radiation  received
is  inversely related to the concentration of
smoke and  suspended particles; thus solar
radiation measurements may be used, in the
absence of clouds, as a crude index of par-
ticulate air pollution.

Table 2-2.—LOSS  OF  SUN'S  RADIATION  IN
   THREE EUROPEAN CITIES OVER THAT IN
   THE ADJACENT COUNTRY.5
                   Solar Elevation
Season
10°
20°
30°
45°

Winter
Spring
Summer
Autumn
Percent
36
29
29
34
Percent
26
20
21
23
Percent
21
15
18
19
Percent
—
11
14
16
  Mateer17  studied the total solar and sky
radiation patterns in  metropolitan Toronto
from October 1937 to 1960 and compared the
radiation received on  Sundays to the aver-
age  of  the  weekday radiation readings at
the same central site. The average radiation
on Sundays for this period was  313.8 lang-
leys (1 langley = l g cal/cm2) while the mean
for the weekday radiation was  305.2 lang-
leys, a difference of 8.6 langleys or 2.8 per-
cent.  The probability of  obtaining  such a
difference by chance was less than 0.5 per-
cent.  Thus, while a  real difference in radia-
tion exists between  Sundays  and weekdays,
the magnitude is rather small.
           4.  Other  Variations
  Hand 1S has noted that  the average  daily
solar radiation in various  cities was  signifi-
cantly higher over the entire year 1932 than
over the prior year.  The largest increase in
solar radiation was found to be in New York
City ( + 21.9 percent), while Pittsburgh and
Washington  showed yearly increases of 6.2
percent and 8 percent respectively. The busi-
ness depression was probably a major factor
in this   increase.  Records for New York,
Chicago, and Pittsburgh  for the year 1932
showed the  marked  diminution in dust and
smoke levels resulting from the falling off
in the amount of manufacturing during this
period.

   D.  INFLUENCE ON PRECIPITATION

  There is evidence  that some of the parti-
cles introduced into the atmosphere by man's
activities can act as nuclei in processes which
affect the formation of clouds and  precipi-
tation.
  Condensation  nuclei  in  the size range
greater than l/j. are often made up of hygro-
scopic particles.19-20  Because of their affinity
for water, these particles play an important
role in the transformation  and condensation
of water vapor into liquid water droplets or
solid  ice particles, and are of vital impor-
tance in the formation of fog, clouds, and
rain.  Combustion products of man's indus-
try and technology, as well as volcanic erup-
tions and ocean spray, are significant sources
of these nuclei. A parallelism exists  between
the concentration of dust and that of conden-
sation nuclei in city air.  (See Table 2-3.)

Table 2-3.—MEAN  NUMBER OF CONDENSATION
   NUCLEI FOR  VARIOUS  RANGES OF  DUST
   CONCENTRATIONS IN CITY AIR.19
                                     Number of
                                    dust particles
                                      per cm3
                                       <500
                                     500-999
                                       >999
                                                  Mean number of
                                                 condensation nuclei
                                                      per cm3
                                                      189,000
                                                      211,000
                                                      223,000
                                   A pronounced  parallelism  can also be
                                 found  with respect to  diurnal and annual
                                 variations  in  the contents of  atmospheric
                                 dust and nuclei.16-19~22 The excess production
                                 of condensation  nuclei in the air over cities
                                 is a long established fact,5-20-23 and has been
                                 reaffirmed  with  many  amplifying circum-
                                 stances.22- 23  Evidence  has been  presented
                                 that giant nuclei, which may initiate the coa-
                                 lescence  process, are more abundant in in-
                                 dustrial areas than elsewhere.16
                                   The  diurnal, weekly,  and yearly cycles of
                                 both suspended and dustfall particle concen-
                                 trations, correspond closely to man's pattern
                                 of activities  and combustion  requirements.
                                 There  are  usually  two  diurnal peaks  (see
       40

-------
Figure 2-3), greater midweek concentrations
compared to Sundays, and greater mean con-
centrations in winter than in summer (see
Figure 2-4).16
  A correlation has been found between pat-
terns of precipitation over cities and the ad-
n
 8
   CT| I   I*  1   j«,, i — ii |   |   |   |   j   j   y   j
      INEFFICIENT     SMOKE FROM NEIGHBORING
     •COMBUSTION^^ DISTRICTS

   4°JEFFECT  "^Im/ SMOKE
   30
                  X   ^"*^v^
                 /EFFECT OF    5?
                f  TURBULENCE^*
     'EFFECT OF
      TURBULENCE'


X.COAL CONSUMPTION
                                 V
     024  6  8  10  12 14  16  18  20  22 24
                   CLOCK TIME

FIGURE 2-3.  Causes of Cyclical Diurnal Smoke Vari-
  ations.16 (This figure shows causes of changes in
  the diurnal airborne particulate concentration in
  an urban location.)
   2.0
 I

 §1.6
  I
 CM
 31.0
 5
 in
 O
   0.5
            TOTAL INSOLUBLE MATTER
TOTAL DISSOLVED MATTER
                OC  >  Z  J  O  fc   H  >  O
FIGURE 2-4.  Yearly  Cycle  (Averaged  Over Six
  Years) of Deposited Pollutants.  (This figure illus-
  trates the variation of amount of pollutants de-
  posited at Leicester town hall averaged over the
  six  years ending March  1939, and shows the
  greater mean concentration in winter as compared
  with summer.)
jacent countryside and the variations of par-
ticle  concentrations  in the atmosphere.22-24
The influence  of cities on precipitation is
complex;  however, there is a general tend-
ency for urban factors to increase precipita-
tion.23 These factors, not necessarily in order
of importance, are:
    1. water  vapor  addition from  combus-
       tion sources and processes;
    2. thermal updrafts from local heating;
    3. updrafts from increased friction tur-
       bulence;
    4. added  condensation nuclei leading to
       more ready cloud formation; and,
    5. added nuclei which may act as freez-
       ing nuclei for super-cooled cloud par-
       ticles.
  Landsberg 23 cites as evidence the gradual
increase  of  rainfall  which  followed  the
growth of Tulsa,  Oklahoma, from  a village
to a city in five decades and the concomitant
increase in  particle concentrations.  A  study
by Kline and Brier 25 in metropolitan Wash-
ington, D.C.,  indicates that there is a con-
siderably higher level  of freezing nuclei in
the metropolitan area than there is in the ad-
jacent countryside.
  Ashworth 24  first suggested the  correlation
between the weekly cycle of smoke in indus-
trial areas and that  of precipitation.  Fred-
erick,26 in a more recent analysis, showed a
definite minimum Sunday rainfall for a ten-
year  period in Louisville, Pittsburgh, and
Buffalo.23'26 Precipitation occurred  in these
less often  on  Sundays than on  other days
of the week,  and the  average rainfall was
less for   Sundays  than  for weekdays.  A
strong city influence is also suggested in the
snow  patterns in Toronto.27
  An interesting and significant  increase in
precipitation has been observed at La Porte,
Indiana, since 1925.   La Porte is  30  miles
east of the large  complex of heavy indus-
tries  in  the  metropolitan  Chicago  area.
Changnon28  compared precipitation at La
Porte, Valparaiso, and South Bend, Indiana,
with a five-year moving average of the num-
ber of smoky and hazy days in Chicago  (Fig-
ure 2-5).  The temporal distribution of the
smoke-haze days after 1930 is rather similar
to the La Porte curve.  A notable  increase in
                                                                                 41

-------
 smoke-haze  days began in 1935, becoming
 more marked after 1940, coincident with the
 sharp increase in the La Porte precipitation
 curve.  The reduction in the frequency of
 smoke-haze  days after  the  peak reached in
 1947 also generally  matches the decline of
 the La Porte curve since 1947.28
   Stout29 has shown that the shape of the
 time-series curve for La Porte precipitation
 also generally matched a time-series curve
 for  annual steel production in  the Chicago
 industrial complex. Between 1905 and 1965,
 peaks in  steel  production,  which  occurred
 when  production in  most  other industries
 was also  high, were all  associated with high
 points in  the La Porte precipitation curve.
   The effect of industrial pollution on pre-
 cipitation has also been  studied by Telford.30
                                               He found that smoke from steel furnaces was
                                               a prolific source of freezing nuclei,  increas-
                                               ing  counts  by a factor of 50 over those in
                                               nearby clean air.  He concluded that there
                                               should  be  increased  rainfall downwind  of
                                               such installations.

                                                   E.   RELATION TO WORLDWIDE
                                                          CLIMATIC CHANGE
                                                 Theoretical considerations and empirical
                                               evidence indicate that atmospheric turbidity,
                                               itself a function of aerosol concentration, is
                                               an important factor in the heat balance  of
                                               the  earth-atmosphere system. The observed
                                               increase in  turbidity over the past few dec-
                                               ades may play a role in the reported decrease
                                               in worldwide air temperature since 1940 by
                                               increasing the planetary albedo.7-31
   300
   270
o
z
o
(L
O
   240
   210
   180
   150
                                                                CHICAGO
                                                                SMOKE HAZE
                                                                DAYS
                OBSERVER
                CHANGES AT
                LA PORTE
                                                                                1800
                                                                                 1400
                                                                                 1000
                                                                                 600
                                                                                        o
                                                                                        UJ
                                                                                        N

                                                                                        X
                                                                                        Q
                                                                                        2
                                                                                        <
                                                                                        UJ
                                                                                        C/J
                                                                                        I
                                                                                         _
                                                                                        O
                                                                                        DC
                                                                                        HI
                                                                                        CQ
                                                                                        5
                                                                                 200
           1910
                       1920
                                   1930
                                                1940
                                                            1950
                                                                        1960
                           ENDING YEAR OF 5-YEAR MOVING AVERAGE
FIGURE 2-5. Precipitation Values at Selected Indiana Stations and Smoke-Haze Days at Chicago. (This figure
  shows the way in which precipitation trends at La Porte follow the haze changes in Chicago. The results are
  plotted as five-year moving averages.)
       42

-------
   Angstrom estimated roughly that a change
in the albedo  from 0.40 to 0.41 corresponds
to a change in the mean temperature of the
earth-atmospheric system of close to 1°  C.32
Humphreys 33  made similar calculations with
roughly the same results, and  also showed
that the interception of outgoing radiation
by fine atmospheric dusts is wholly negligible
in comparison with the interception of in-
coming solar  radiation.  Temporal and spa-
tial changes in the atmospheric turbidity of
100 percent, corresponding to albedo changes
of 10 percent to 15 percent,  from  one  day
to the next or from one locality to  another,
are very commonplace.31 Even though these
figures  may  well  overestimate the actual
changes brought about in atmospheric tem-
peratures, the course of atmospheric turbid-
ity over the earth  is an important  climatic
factor.
   There are data available 31-34 from which
the trend in turbidity during1 the past cen-
tury can be estimated.  Angstrom gave 0.098
as the value of the mean annual turbidity at
Washington,  B.C.  (1903  to  1907)," and
0.024 as the value at the Davos Observatory,
Switzerland (1914 to 1926).  The values for
Washington were determined from  data on
solar transmission  (by wavelength)  pub-
lished by the  Smithsonian Institution;  those
for Davos were from data attributed to Lind-
holm on dust absorption.  In  1962, deter-
minations of the atmospheric turbidity were
begun  at the Continuous Air Monitoring
Program station 31-35 of the  Public Health
Service,  near  the Smithsonian Institution;
the mean annual turbidity recorded for 1962
to 1966 was 0.154,35 a 57 percent increase
over the 1903 to 1907 values.  From 1957
to 1959, determinations of atmospheric tur-
bidity were again made for Davos by Valko 3G
and  were given as 0.043, a  70 percent in-
crease.
  When the scattering theory with a Junge
distribution of  particle  size4 is  used,  the
values of turbidity change imply an increase
in the average annual number of aerosol par-
ticles, in the range of O.l/i to 1/j. radius, of
2.8xlOTcm2 and  0.95xlOT/cm2  over Wash-
ington and  Davos  respectively, during  the
periods  shown.   Nearly two-thirds of  the
Washington increase might be attributed to
the increased population and urbanization of
the District since the turn  of the century.
A significant remainder, however, as judged
by the Davos increase, may be indicative of
a much more general buildup of atmospheric
aerosol.
   When the above  facts are put together,
they indicate that for Washington, D.C., dur-
ing the period  1903 to 1966, there has been
a  possible decrease of  nearly 3  percent in
the total  available solar energy at ground
level and  a possible increase in the average
annual  number   of aerosol  particles  of
2.8 X 107cm-'.  The net effect of this apparent
secular  increase  in turbidity  (which from
the Davos, Switzerland, and other evidence 34
appears likely to be worldwide) is probably
to increase the mean  albedo of  the  planet
and  reduce the  mean  temperature of  the
earth-atmosphere system.
   The  increase  in atmospheric turbidity
consequent  upon  volcanic  eruptions  may
have temporary effects on atmospheric tem-
peratures.  Mitchell37  concluded  that  tem-
peratures over  large areas of the world may
be depressed by 0.5° F or more  in the first
or second year following an unusually violent
eruption.   However, McCormick  and Lud-
wig 31 suggest that the effects of man's pol-
lution  of  his  environment  are  increasing
steadily along  with the  world  population.
The emission of long-lived particles, keeping
pace with the accelerated worldwide produc-
tion  of  CO;., may well be leading to the de-
crease in  world air temperature  in spite of
the apparent buildup of CQ2.™

             F.   SUMMARY
  Atmospheric particles scatter and absorb
light from the sun, thus reducing the visible
radiation  available  to cities  and the solar
radiation that reaches the earth.  The gloom
due to reduced illumination  in urban  areas
creates a need for artificial lighting in offices,
factories,  and  homes and produces related"
economic stresses.  The average year-round
illumination (i.e.,  the  portion of the  spec-
trum that is visible to the eye) may  be re-
duced by  one-third or more in some cities.
Daylight illumination in the center of Lon-
don,  for example,  was found to be 20 per-
cent  less than that found at a slightly less-
                                                                              43

-------
polluted part of the city quite near the center.
  Part of the sunlight reaching the earth
comes from the direct  beam and part from
that scattered from the rest of the sky. The
total solar energy reaching the earth is the
sum of both the direct and the scattered ra-
diation.  In general,  cities receive  15  per-
cent to 20 percent less total solar radiation
than do rural environments, although the net
reduction may be considerably greater under
some circumstances.   For a  typical urban
area in the United States, with a geometric
mean annual  concentration of  roughly  100
/ig/m3, the total sunlight is reduced approxi-
mately 5 percent for  every doubling of par-
ticle concentration. This effect is more pro-
nounced on the ultraviolet portions of the
spectrum.
  Diurnal, weekly, and yearly cycles of both
suspended particulates and dustfall particles
correspond closely to man's pattern of activi-
ties  and his combustion requirements. There
are usually two daily peaks, greater midweek
concentrations compared with Sundays, and
greater mean concentrations in autumn and
winter than in spring and summer. The sea-
sonal variations are due  largely to  the use
of coal and heavy fuel oil for heating pur-
poses. Solar radiation  attenuation patterns
also  show weekly  and seasonal variations.
On   weekdays, the attenuation  is  slightly
more than on Sundays, and the losses in in-
tensity of the  direct beam during its  passage
through an atmosphere polluted by smoke
may become as high as one-third in the sum-
mer and two-thirds in the winter. Even vari-
ations from year  to year  have been noted;
for example,  levels of  total  solar radiation
measured in various cities  were significantly
higher in  1932 than  in the prior year,  un-
doubtedly  because  of the  decline in manu-
facturing  and industrial  activity brought
about by  the  depression.  Reductions in the
intensity of solar radiation or changes in its
spectral  distribution  have significance  for
the photosynthesis of vegetation, the distri-
bution of plants  and animals on the earth,
the weathering of natural and manmade ma-
terials,  and man's aesthetic  enjoyment and
physical well-being.
  The increased emission of fine particles
into  the atmosphere also may cause changes
in the delicate  heat  balance of the earth-
atmosphere system, thus altering worldwide
climatic conditions. The rise in atmospheric
turbidity increases the planetary reflectivity,
or albedo, and reduces the solar energy avail-
able to maintain surface temperatures.  This
phenomenon may be  responsible for the re-
ported decrease in worldwide  temperature
since the  1940's.  Comparisons at  different
sites over the world covering periods as long
as fifty years  suggest that a general world-
wide  rise  in turbidity may be taking place.
This  may  well  be  indicative of a  gradual
buildup of worldwide background  levels  of
suspended  particulates. The increasing lev-
els of atmospheric carbon dioxide resulting
from man's combustion  of  fuels  probably
exerts an  opposite effect on worldwide  tem-
peratures, but the emission of long-lived par-
ticles to the air may gradually depress world
air temperature despite the apparent build-
up of carbon dioxide.
  Some of the particles introduced into the
atmosphere by man's activities also can af-
fect the weather by serving as condensation
nuclei that influence the formation of clouds,
rain,  and snow.  The large airborne particles
generated in metropolitan areas serve  as a
base  for the condensation of moisture and
lead to the rapid formation of rain droplets
or ice crystals.  Patterns of  precipitation
over cities and the adjacent countryside  have
shown a correlation with particle concentra-
tions  in the atmosphere. Some cities display
a  definite  minimum  rainfall  on Sundays,
when participate levels are  usually  lowest,
and records over several decades reveal that
rainfall levels may increase with  the  con-
comitant rise in particulate levels that  gen-
erally accompanies urban growth.  In addi-
tion,  long-term changes in the frequency  of
smoke-haze days in one city may affect rain-
fall levels in a nearby  downwind city.
  Thus airborne particles  can, through  a
number of mechanisms, influence man's sur-
roundings and have  considerable impact  on
weather and climatic conditions.

            G.  REFERENCES
 1. Sheppard, P.  A.  "The Effect of Pollution  on
   Radiation in the  Atmosphere."  Intern. J. Air
   Pollution, Vol. 1, pp. 31-43, 1958.
       44

-------
 2.  McCormick, R. A. and Baulch, D. M.  "The Vari-    17.
    ation with Height of the Dust Loading over a
    City as Determined from the Atmospheric  Tur-
    bidity." J. Air Pollution  Control Assoc., Vol. 12,
    pp. 492-496, 1962.                                 18.
 3.  Sheleikhovskii,  G.  V.   "Smoke  Pollution  of
    Towns." Akademiya Kommunal'nogo  Khzyaistva
    im.  K. D.  Pamfilova. [Academy  of Municipal    19.
    Economy im.  K. D. Pamfilova.]  IzdatePstvo  Min-
   isterstva  Kommunal'nogo Khozyaistva  RSFSR,
    Moskva-Leningrad.   1949.  (Translated   from    20.
    Russian and published for the National Science
    Foundation, Washington, D.C. by the Israel Pro-
    gram  for  Scientific  translations,  Jerusalem,    21.
    1961.)
 4.  Volz,, F.  "Photometer mit  Selen-Photoelement
    zur  spektralen  Messung der   Sonnenstrahlung
    und zur Bestimmung der  Wellenlangenabhangig-    22.
    keit der Dunsttrubung." Arch. Meterol. Geophys.
    Bioklimatol., Ser. B, Vol. 10, pp 100-131,  1959.
 5.  Landsberg, H. "Physical Climatology."  2nd edi-    23.
    tion, Gray, DuBois,  Pennsylvania, 1958, pp.  317-
    326.
 6.  Angstrom, A. K.  "On the Atmospheric Trans-
    mission of Sun Radiation II."  Geograph.  Ann.
    (Stockholm), Vol. 12, pp. 139-159, 1930.           24.
 7.  McCormick,  R.  A.  "Atmospheric  Turbidity."
    Preprint.   (Presented at  the 60th Annual Meet-
    ing, Air  Pollution  Control  Association, Cleve-
    land, Ohio, June 11-16, 1967.)                       25.
 8.  Stagg, J.  M.  "Solar Radiation of Kew Observa-
    tory." Air Ministry, Meteorological  Office,  Lon-
    don, Geophysical  Memoirs 86, 1950.
 9.  Gates,  D. M.  "Spectral  Distribution  of Solar    26.
    Radiation at the  Earth's  Surface." Science, Vol.
    151, pp. 523-529, 1966.                            27.
10.  Robinson, N.  "Solar Radiation." Elsevier,  Am-
    sterdam,  London and New York, 1966.
11.  Angstrom, A. K.  "On the Atmospheric Trans-    28.
    mission of Sun Radiation and Dust in the Air."
    Geograph. Ann.  (Stockholm), Vol. 11, pp.  156-
    166, 1929.                                        29.
12.  Shrader,  J. H., Coblentz,  M. H.,  and Korff, F. A.
    "Effect of Atmospheric Pollution upon Incidence
    of  Solar  Ultraviolet  Light."  Am.   J.  Public
    Health, Vol. 19, pp. 717-724, 1929.
13.  Steinhauser,   F.,   Eckel,  O., and  Sauberer,  F.
    "Klima und  Bioklima von Wien." Wetter und    30.
    Leben, Vol. 7, 1955, 120 pp.
14.  Kenrick,  G.  W. and Ortiz, H.   "Measurements
    of Ultra-Violet Solar Radiation  in Puerto Rico."    31.
    Trans. Am. Geophy. Union, 19th, 1938, pp.  138-
    140.
15.  Meetham, A.  R.  "Atmospheric  Pollution  in    32.
    Leicester. A Scientific Survey."  Dept. of Scien-
    tific and  Industrial  Research,  London, Atmos-
    pheric  Pollution   Research Technical Paper 1,    33.
    1945.
16.  Meetham, A. R.  "Atmospheric Pollution: Its
    Origin and  Prevention."  Pergamon Press,  New
    York, 1961.
Mateer, C. L.  "Note on the Effect of the Weekly
Cycle of  Air Pollution  on  Solar Radiation at
Toronto."  Intern. J.  Air Water Pollution,  Vol.
4, pp. 52-54,  1961.
Hand,  I.  F.  "Solar  Radiation Measurements
During December 1932." Monthly Weather Rev.,
Vol. 60, pp. 256-257, 1932.
Neuberger, H. "Condensation Nuclei: Their Sig-
nificance in Atmospheric Pollution."  Mech. Eng.,
Vol. 70, pp. 221-225, 1948.
Landsberg, H.  "Atmospheric  Condensation Nu-
clei." Erg. Kosm. Physik., Vol.  3,  pp.  155-252,
1938.
Giner, R.  and Hess,  V. F. "Studie uber die  Ver-
teilung der Aerosole  in  der Luft von Innsbruk
und Umgebung." Gerlands Beitr. Geophys., Vol.
50,  pp. 22-43, 1937.
Georgii, H. W. "Probleme und Stand der Erfor-
schung  des  Atmospharischen  Aerosols."   Ber.
Deutsche Wetterdienste., Vol. 7, pp. 44-52, 1959.
Landsberg, H.  "City Air—Better  or  Worse."
In:   Air  Over Cities  Symposium, U.S.  Dept. of
Health,  Education, and Welfare, Robert A.  Taft
Sanitary Engineering Center,  Cincinnati, Ohio,
Technical Report A62-5, 1962, pp.  1-22.
Ashworth,  J.  R.  "The Influence of Smoke and
Hot Gases from  Factory Chimneys on Rainfall."
Quart. J.  Roy. Meteorol. Soc., Vol.  55,  pp.  341-
350, 1929.
Kline, D.  B.  and Brier, G.  W.   "Some Experi-
ences on the Measurement of  Natural  Ice  Nu-
clei." Monthly Weather  Rev..  Vol.  89,  pp.  263-
272, 1961.
Frederick,  R.  H.  Personal communication.  U.S.
Weather Bureau.
Potter, J. G.   "Changes in Seasonal Snowfall in
Cities."  Canadian Geographer, Vol. 5, pp. 37-42,
1961.
Changnon, S. A. Jr.  "The La  Porte  Weather
Anomaly, Fact or Fiction."  Bull. Am. Meteorol.
Soc., Vol. 49, pp. 4-11, 1968.
Stout, G.  E.  "Some Observations of Cloud Ini-
tiation in Industrial Areas." In:  Air Over Cities
Symposium,  U.S.  Dept. of  Health,  Education,
and Welfare, Robert A. Taft Sanitary Engineer-
ing   Center, Cincinnati, Ohio,  Technical Report
A62-5, 1962, pp.  147-153.
Telford, J. W. "Freezing Nuclei from Industrial
Processes."  J. Meteorol., Vol.  17,  pp.  676-679,
1960.
McCormick, R. A. and  Ludwig, J.  H. "Climate
Modification by Atmospheric Aerosols."  Science,
Vol. 156, pp. 1358-1359, 1967.
Angstrom,  A. K. "Atmospheric  Turbidity,  Glo-
bal   Illuminators  and  Planetary Albedo of the
Earth."  Tellus,  Vol. 14, pp.  435-450,  1962.
Humphreys,  W.  J.  "Volcanic  Dust and Other
Factors in the Production of  Climatic  Changes
and their Possible Relation  to  Ice Ages."  Bull.
Mount.  Weather  Observatory,  Vol. 6, pp. 1-34,
1914.
                                                                                            45

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34.  Peterson, J. T. and Bryson, R. A. "Atmospheric
    Aerosols: Increased Concentrations During the
    Last Decade."  Science, Vol. 162, pp. 120-121,
    1968.
35.  "Atmospheric Turbidity Report." U.S. Dept. of
    Health,  Education, and Welfare, National Cen-
    ter for Air Pollution  Control, Cincinnati, Ohio.
    (Quarterly)
36.  Valko,  P.  "Untersuchung  iiber die  vertikale
    Triibungsschichtung  der  Atmosphare."   Arch.
    Meteorol. Geophys. Bioklimatol., Ser. B, Vol. 11,
    pp. 143-210, 1961.
37.  Mitchell, J. M., Jr.  "Recent Secular Changes in
    Global  Temperatures."  Ann.  N.Y. Acad.  Sci.,
    Vol. 95, pp. 235-250, 1961.
38.  "Restoring  the Quality of Our Environment."
    Report of the  Environmental Pollution Panel,
    President's  Science Advisory Committee,  The
    White House, Washington, D.C., November 1965,
    pp. 111-131.
        46

-------
              Chapter 3
EFFECTS OF ATMOSPHERIC PARTICULATE
        MATTER ON VISIBILITY

-------
                           Table of  Contents
                                                                     Page
A. INTRODUCTION                                                  51

B. IMPORTANCE OF ATMOSPHERIC  AEROSOLS  TO  THE GEN-
   ERAL OPTICAL PROBLEM                                        51

C. PHYSICAL RELATIONSHIPS BETWEEN VISIBILITY AND PAR-
   TICLE CONCENTRATION                                 .        52

D. COMPLICATIONS AND LIMITATIONS IN THE  VISIBILITY
   PROBLEM                                                        53
   1.  Smoke Plumes                                             .      53
   2.  Natural Aerosols and Hazes                                   .    53
   3.  Fogs                                     	     54

E. THE  LOW-HUMIDITY, WELL-AGED HAZE .                .       54
   1.  Size Distribution                         .                ...     54
   2.  Mie Solutions                                           ...       54
   3.  Dependence of Extinction of Particle  Size for the Atmospheric Case
   4.  The Mass-Light Scattering Relationship                       .      55

F. DETERMINATION OF WELL-DEFINED CASES OF MASS-
   VISIBILITY RELATIONSHIPS                              .   .    58

G. METHODS FOR  DETERMINING LIGHT  SCATTERING COEFI-
   CIENT-MASS CONCENTRATION RELATIONSHIP          ...     59
H. SUMMARY                                                  ..      60

I.  REFERENCES                                             .  ...    61

                            List of Figures
Figure
3—1  Four Typical Measured Size Distributions of Atmospheric Suspended
     Particles Together with the Corresponding Visibilities                 54
3-2  The Relation of Scattering Cross-Section to Particle Size for Parti-
     cles of Three Different Refractive Indices                           55
3-3  Cross Section Curve for Typical Atmospheric Size Distribution     .    55
3-4  The Dependence of Scattering Coefficient (m-1) on Volume of Aero-
     sol  Particles (/*3/cm3) Calculated from Measured Size Distributions      56
3-5  Measured Dependence of Mass of Aerosol Particles per Volume  (/tig/
     m3)  on the Light Scattering Coefficient (nr1) in Seattle, November-
     December 1966                                                   56
3-6  Histogram of Equivalent Visual Range-Mass Concentration Product
     at Several Locations                .        ...               57
3-7  Relation Between Visual Range and the  Mass Concentration           57
3-8  Three Horizontal Profiles through  the City of Seattle Taken under
     Differing Meteorological Conditions      .   .         	     59

      48

-------
                             List  of Tables
Table                                                                   Pa<>e
3-1  Relation Between Equivalent Visual Range and Particle Concentra-
     tion  .               .                	       57
3-2  The Relative Humidity at which Phase Change Occurs in Some De-
     liquescent Aerosols   .              	      59
                                                                            49

-------

-------
                                      Chapter 3

   EFFECTS  OF ATMOSPHERIC PARTICULATE  MATTER  ON  VISIBILITY
           A.   INTRODUCTION
  One of the  dramatic effects of air pollu-
tion is a degradation of the visibility.  Visi-
bility in the atmosphere is reduced by two
optical effects which air molecules and aero-
sol particles have upon visible radiation. One
is the attenuation by the molecules and par-
ticles of the light passing from object to ob-
server.  It is  the result  both  of absorption
of light and of the scattering of light out of
the  incident beam.  The light  received from
the  object  and that  received from  its back-
ground  are diminished by this  attenuation,
and  the difference  between  the two  (con-
trast)  is  consequently diminished  with the
result that the eye's ability  to distinguish the
object from its background is reduced. The
other optical effect that degrades the contrast
between object and background is the illumi-
nation of the  intervening air which results
when sunlight is scattered into the line of
sight by the molecules and particles in the
line  of  sight.  It is  a common  observation
that  dark  objects   become  progressively
lighter in shade as they become more distant.
The most distant mountain that  one can dis-
tinguish typically is almost as light or bright
as its sky background.
  In those cases where a clear-cut relation-
ship can be shown to exist between visibility
and the mass of suspended particles per vol-
ume of  air (mass concentration), it is pos-
sible to use some of  the meteorological  visi-
bility records  to infer the  amount  of pollu-
tion in past years as well as to study trends.
In fact, many such studies have been made
even without a substantive knowledge of the
relationship.  Holzworth 1 used existing  visi-
bility data both as  an  indication of  the
amount of pollution  for comparison of an
urban  (Columbus, Ohio) area with a rural
area, and  for the qualitative  inference of
trends of  both increasing  and  decreasing
amounts of smoke or other atmospheric aero-
sol. Robinson - also discussed the use of me-
teorological  visibility  records   and  their
interpretation.  Both Holzworth 1 and Robin-
son -  demonstrated that visibility  degrada-
tion can be  associated with  air pollution.
Neither, however, developed the sort of cor-
relation between mass of suspended particu-
late matter per volume of air and  visibility
that is needed for air quality criteria. Rob-
inson indicated doubt in the existence of a
generally  applicable  relationship  between
mass   concentration  and  visibility.  This
doubt was  based  on experimental results as
well as on the complexity of the  problem.
Recent  experimental  and  theoretical ad-
vances  make possible some useful conclu-
sions, and  this  chapter will define  a simple
relationship between mass of suspended par-
ticles   and  visibility,  specify  the  circum-
stances under which it can be expected to be
reliable,  and  describe the conditions which
are too complex for this simple treatment.
  In the United States, the words  visibility
and visual range are usually used synony-
mously to  mean the distance at which it is
just possible  to perceive  an object against
the horizon sky.  Middleton3  reports that
the originator  of both terms  intended that
only visual range be considered as a distance,
while visibility should convey  a more quali-
tative judgment about the clearness of see-
ing. In this chapter, however, the terms visi-
bility and  visual  range will be used inter-
changeably to mean a distance.

  B.  IMPORTANCE  OF  ATMOSPHERIC
     AEROSOLS  TO THE  GENERAL
           OPTICAL  PROBLEM
  Decreased  visibility obviously interferes
with  certain important  human activities,
                                                                              51

-------
such as  the  safe operation of aircraft  and
automobiles  and the  enjoyment of scenic
vistas. The effect of decreased visibility on
the large-scale operations of commercial  air-
craft  in  metropolitan areas is a  problem of
growing concern.  The  Federal Air Regula-
tions  of 19674  (paragraphs  91.105   and
91.107)  prescribe limitations on aircraft op-
eration  that  become increasingly severe as
visibility decreases below five miles. Most re-
strictions are invoked when the visibility is
below three miles. In areas with a high den-
sity of aircraft traffic, visibilities much below
five miles tend to slow down operations by
maintaining larger separations between  air-
craft. Even  though most commercial  air-
planes always fly under  Instrument Flight
Rules rather than Visual Flight Rules, good
visibility increases  both the safety and per-
mitted traffic density. Light airplane opera-
tions  are limited even  more  severely when
visibility is less than three miles, because of
their  limited instrument flight capability.
  A 1963 report by the Civil Aeronautics
Board to the Committee on  Public Works,
U.S. Senate,5 states  that records  of both au-
tomobile and aircraft accidents  show cases
where poor visibility due to smoke and air
pollution was an important  causal  factor.
Evidence presented  at Federal air pollution
abatement conferences e-7  shows  the  exist-
ence of  air pollution that curtails visibility,
endangering  the  safety  of people traveling
by both  land and air, and in addition, causing
inconvenience and economic loss  to the pub-
lic and  to transportation companies due to
disruption of traffic  schedules.


    C.   PHYSICAL RELATIONSHIPS
      BETWEEN VISIBILITY  AND
      PARTICLE  CONCENTRATION

  Many  derivations of visibility theory have
been  published.  Although Robinson's2  ap-
proach is directed towards the air pollution
problem, Middleton's 3 book presents a more
complete view of the problem of atmospheric
clarity.
  For the simplest  case of attenuation of a
light  beam along its path,  the  intensity, I,
decreases by an  increment dl over the in-
crement  of path dx.  The  relationship be-
tween intensity and distance is:
                dl
or, in integrated form,
                                     (3-1)
                                     (3-2)
                                  abs-gas'
where b is the extinction coefficient assumed
to be constant over x, and I0 represents the
intensity of light at x = 0.
  The extinction coefficient, b, is the sum of
four terms:
  1. the scattering coefficient of the air mole-
     cules, b^   .  . ,  ;
            Rayleigh
  2. the  scattering coefficient of particles or
     aerosol, b    , :
              scat
  3. the light absorption by gases, b
     and,
  4. the  light absorption by the aerosol, b
     abs-aerosol.
  Of these four, the scattering due to aerosol
is usually assumed to dominate in haze.2 The
process of scattering amounts to the removal
of light from the original beam and its redis-
tribution  in  different directions. Scattering
thus differs  from absorption in which the
light energy is lost to the absorber; in scatter-
ing, the light energy is only spatially redis-
tributed. Nonetheless, this removal of light
from the beam (or line of viewing) does  re-
sult in extinction.  It suffices to state only the
final  result in  equation 3-2 for the usual
assumption of 2% contrast threshdld for an
"average" human eye.2-3
                    3.9
                    b
                      scat
                                     (3-3)
  Here, Lv is the visual range in meters and
b is, as before, the extinction coefficient per
meter along the path of sight for the case of
a black object. If b is  determined at a point
without knowledge of  the entire sight path,
then Lv is "equivalent  visual range," i.e., the
distance one could see if the extinction coeffi-
cient were constant along the sight path. A
discussion  of  the dependence of  extinction
coefficient  on  the  amount of  atmospheric
aerosol follows in Section F.
       52

-------
  "Visual quality" as perceived by even the
well-trained observer is not so easily describ-
ed. Among the complications is the fact that
particles responsible for urban haze scatter
more light in a direction close to that of the
original  beam  (so-called  forward-scatter)
and less light in a backward direction. Thus,
the same haze may appear to be much more
dense when looking toward the sun and less
dense when looking away from the sun.
  Besides this directional factor, there is also
a wavelength  (or color)  dependence. Ang-
strom,8 Junge,9 and others have shown that
the extinction coefficient of hazes in general
is inversely proportional to a power of wave-
length:
              b  =  —
                    Aa
(3-4)
where a has measured values of around 1.0 to
1.5. This relation indicates that blue light (of
shorter wavelengths) will be  scattered to a
greater  degree  than red light  (of  longer
wavelengths). It is for this reason that the"
sun's disc, when observed through a haze that
is dense  enough to permit such viewing, ap-
pears red, orange or even brown though light
absorption is not necessarily occurring.

D.   COMPLICATIONS  AND  LIMITATIONS
     IN  THE VISIBILITY PROBLEM

            1.   Smoke Plumes
  Conner and Hodkinson,10  in tests on  the
optical properties of well-controlled experi-
mental smoke, found that visual  effects  are
not inherent properties of the plumes  but
vary with the background of the plume and
with  illuminating  and  viewing  conditions.
Variation  was  much   greater with  white
plumes than with black.  Tests conducted with
trained  smoke inspectors showed that their
evaluations of non-black smoke plumes were
significantly influenced  by these  variations.
  At least two real difficulties exist in making
any  generalizations about visual aspects of
smoke plumes. First, it  is not possible to de-
termine the mass emitted per unit time from
a smokestack solely on  the basis  of visually
perceived light  scatter or absorption.  The
mass per unit time emitted from the  stack
and not the appearance  or optical properties
of the plume is pertinent to the eventual air
composition, even though appearance may be
aesthetically objectionable.
  Secondly, although  many meteorological
mixing  equations have been proposed, they
cannot describe individual eddies of smoke as
the plume disintegrates. The equations were
meant for describing  averages and not an
instantaneous property such as the extinction
of light in some particular  eddy of smoke as
determined by eye, perhaps with the aid of a
Ringelmann Chart.
  Because of these problems, the topics of
plumes  and plume optics are discussed only
briefly in this chapter, and  the presentation
is concerned primarily with the aerosol pro-
duced after the initial meteorological mixing
of the plume has occurred.  The reader is re-
ferred for further information  on plume op-
tics to the study by Conner and Hodkinson.10
  The Ringelmann number may  provide an
objective  measurement of  public sentiment
regarding  the  disagreeable appearance of
smoke plumes, although aesthetic  aspects are
difficult to quantify. Robinson " shows the as-
sumptions and  size distribution information
that are necessary for relating plume opacity
to the aerosol content of smoke.
  The difficulties inherent  in visual evalua-
tion of  smoke  plumes do not eliminate the
possibility of using such observations as an
aid in controlling air pollution. In principle,
the Ringelmann Chart should  be useful in
estimating the obscuring of vision by plumes
and in setting limits to control  the visibility
degradation downwind from a source of par-
ticulate matter. In practice,  however, the
problem is extremely complex  and requires
extensive  study to develop better techniques
for measuring the contribution  of individual
plumes to visibility problems.

      2.  Natural Aerosols and Hazes
  The general  problem of  natural particu-
late  matter—from  whatever  source—must
be considered. The oceans produce salt parti-
cles, trees produce terpenes that  may result
in  organic  particles,11 forest  fires  make
smoke, and so on. Man  has little hope of con-
trolling  the quality of air  that  enters the
urban areas from uninhabited  lands.  None-
theless,  these low-humidity aerosols  some-
                                                                              53

-------
times cause dramatic reduction in the visual
range. In order to properly evaluate the im-
portance  of  natural aerosols,  the visibility
of the air mass should be determined before
it enters a populated area.

                  3.  Fogs
  When  the  relative humidity exceeds  ap-
proximately 70 percent, many types of parti-
cles exhibit deliquescent behavior and grow
into fog  droplets. Natural particles such as
sodium chloride from the sea as well as many
products  of human  activity  can thus act as
condensation  nuclei  (Chapter 2). The prop-
erty of deliquescence and the relative humid-
ity at which rapid and large change in parti-
cle size occurs are  both very dependent on
the chemical  composition  and  original  size
 of  the particles. As a result,  unless the chem-
ical composition as a function of particle size
is  known for the aerosol,  very little  can be
said  about the relationship  between visibil-
ity in  even  "thin"  fog and the  amount of
 material present  as pollutant.12
   Because  little  deliquescence occurs below
70 percent relative humidity,  the relation-
 ships to  be presented here will be limited to
 the range of humidity from 0 percent to 70
 percent.  In cases of higher humidity,  it is
 possible  to decrease the relative humidity of
 the air by heating  it for optical evaluation
 of the amount of particulate matter, as de-
 scribed by Charlson et ai.13 This  humidity
 limitation has already been adopted  in  Cal-
 ifornia.14

  E.  THE LOW-HUMIDITY, WELL-AGED
                    HAZE
             1.  Size Distribution
    Recent advances  in  both  theory and tech-
 nology have  resulted  in  a  simplification of
 the description of well-aged aerosols. Junge,9
 Friedlander,15 Whitby,16  and others" have
 shown that  aerosols in the lowest region of
 the atmosphere  (troposphere), whether over
  urban areas or not, tend to have similar size
  distributions. Figure 3-1  shows several  typi-
  cal  size distributions  to  illustrate this fea-
 ture.
    If it  is assumed that  this recurring  size
  distribution exists  in general, then it is pos-
3.
Z
cc
LU
z
w10s
2
0
y
I-
<102
u.
O
IT
Z
   	3-4 miles haze - low wind speed-
     high pressure over area. Seattle

   	4-5 miles haze - deep low pressure
     area southwest of area. Seattle

     6-7 miles-rain showers and cumulus
   	clouds - tops near 10,000 feet.
     Seattle

v  __ 10-20 miles (ocean) - high pressure
     over area. Washington seacoast
    .01
                    0.1
                 PARTICLE RADIUS,
                                    1.0
 FIGURE 3-1.  Four Typical Measured  Size Distribu-
  tions  of  Atmospheric  Suspended  Particles To-
  gether with the Corresponding Visibilities.1* (The
  figure shows that aerosols in the lowest region of
  the atmosphere (the troposphere) tend always to
  have similar size distributions.)

 sible to relate  the optical properties of the
 haze to the amount or mass concentration of
 material present. This generalization may
 not apply  to freshly-formed smoke.  Brief
 guidelines  for determining  when the  size
 distribution  has  become  sufficiently  well-
 defined will be given later.

              2.   Mie  Solutions
   As mentioned earlier, another  important
 assumption which is usually made is that, of
 the four extinction components, light scatter-
 ing by aerosols dominates. Current research
 indicates that  this  is probably  a  justifiable
 assumption.13 Figure 3-2 shows  typical scat-
 tering cross sections for  green light as a
 function of particle size for aerosol particles
 important in haze,  computed via the  theory
 of Gustav Mie.18 For some particle sizes, dif-
 ferences in the scattering coefficient of a fac-
 tor of three exist between the two refractive
 indices which span the realistic  range for
 the atmospheric case.  However, Pueschel and
         54

-------
  10-7F
                              	m= 1.60
                              ___m = 1.33
                              	m= 1.59-0.66i
                              	Sot r3
                                                 lio-6
                PARTICLE RADIUS, JU
FIGURE 3-2.  The Relation of Scattering  Cross-Sec-
  tion to Particle  Size for  Particles of Three Dif-
  ferent Refractive Indices.13 (The figure shows that
  the scattering cross-section of atmospheric par-
  ticles varies roughly as the cube of their radius
  within the range 0.1^ to  1.0^. The range of re-
  fractive indices,  1.33 to 1.6, for which the propor-
  tionality holds includes most  materials  found in
  atmospheric aerosols.)

Noll19 conclude that the  extinction coefficient
of aerosols in the troposphere is nearly inde-
pendent of the refractive index of the parti-
cles if the  size distribution  is  close to those
described in Figure 3-1.

 3.   Dependence of Extinction on  Particle
        Size for the Atmospheric Case
  If the  data in  Figures 3-1 and 3-2 are
broken down  into narrow  radius intervals
(e.g., 0.01/i), and a calculation performed to
yield the extinction coefficient for  each ra-
dius interval, the particle size dependence of
atmospheric extinction of green  light is re-
vealed. Figure 3-3 shows the  results for a
typical size distribution of  spherical parti-
cles having a refractive  index of 1.5.
  In  general,  this procedure  shows that a
narrow range of particle sizes, usually from
O.lfjL to I/* radius controls the extinction coef-
ficient and  therefore the visibility. If the
values of the  extinction coefficient for  each
radius interval  are then summed, the  total
                                                 cc
                                                 111
E>
Q
CC
IJ10-'

5
cc
O
u.
H
UJ
O
LU
O
O
(3
CC
HI
E«
u
   i-S
                                                                                   10'6 cm'1
          0.1    0.2   0.3    0.4    0.5
                 PARTICLE RADIUS,(/I)
0.6   0.7
 FIGURE 3-3.  Cross Section Curve for a Typical At-
  mospheric  Size Distribution.19  (The figure shows
  the particle size dependence of  atmospheric ex-
  tinction obtained by breaking down the data of
  Figures 3-1 and 3-2 into 0.01^-radius  intervals,
  to yield the extinction coefficient of each radius
  interval.)

 extinction  coefficient,  due to scatter, bscat, is
 obtained.

 t.   The Mass-Light Scattering Relationship
   It is also possible to  calculate the volume
 of  particulate matter per unit volume of air
 (i.e., in cubic  microns  of aerosol per cubic
 centimeter of air).  The familiar quantity of
 areosol  mass concentration (yug/m3)  is  pro-
 portional to this volume ratio via the particle
 density. Figure 3-4 shows the calculated rela-
 tionship of aerosol volume  (fi3/cm3)  to scat-
 tering coefficient per meter (for green light
 [5500A] and for  a refractive index  of  1.6)
 based on 32 individual measured size distri-
 butions. Sixteen of these  size distributions
 used in Figure 3-4 were measured in Seattle
 under varying meteorological conditions. The
 remaining  16 were obtained in the Austrian
 Alps under conditions  where, presumably,
                                                                                    55

-------
1000
°g300
_JJ
n
a.
ui 100
5
_l
o
> 30
_i
8
o
S 10


3


1 0
m \
E •
' SEATTLE, WASHINGTON »^*'
0

•«
r > '

-


O~O KALKALPEN, AUSTRIA

: o
7 0
_


1UUU
300
n
E
-^.
«100
2
O
H
< 30
cc
H
UJ
^ 10
O
o
§ 3
DC
111
**

-
•

•
r «fc v
F •'*• " *

-
9 ' V
-•

-
-
„

1 	 1 , , . 1 1 ,lll 1 1 1 1 ,1 .1
0.1 0.3 1.0 3 10 30 xlO"4 ""0.1 o.3 1.0 3 10 30 x 10"
         LIGHT SCATTERING COEFFICIENT
FIGURE 3-4. The  Dependence of Scattering Coeffi-
  cient  (w1)   on  Volume  of  Aerosol  Particles
  (///cm3)  Calculated from  Measured Size  Distri-
  butions.13  (The solid circles are based on Seattle,
  Washington, data and the open circles on Kalkal-
  pen, Austria, data.)
only natural  aerosol was present. The im-
plication  of these calculations  is  that the
volume, and thus the mass concentration of
well-aged aerosol, is approximately propor-
tional  to  the  light scattering coefficient for
atmospheric aerosols originating naturally
or as the  result of man's activity.13
  It follows, therefore, that even though the
aerosol mass is distributed over perhaps two
or three decades of size,  and light scatter is
caused by particles of one narrow size range,
a proportionality can exist between the num-
ber of particles scattering light and the total
mass  concentration  of  particles.  Constant
shape  of the  size distribution here implies
that for all radius intervals, the number  of
particles  in an interval is proportional to the
number in the corresponding interval in a
reference size distribution.
   Figure 3-5  shows data obtained by an in-
tegrating nephelometer 1S for a  wavelength
of 5000 A confirming this calculated depend-
ence. The relationship can be summarized as
follows:
     mass (/ig/m3)~3xl05 bscat/m.   (3-5)

Figure 3-6 shows data like  those of Figure
        LIGHT SCATTERING COEFFICIENT b^^/m

FIGURE 3-5. Measured Dependence of Mass of Aero-
  sol Particles per Volume (/jg/m3)  on the Light
  Scattering Coefficient (wr1) in Seattle, November-
  December 1966.13
3-5 plotted in a different fashion to illustrate
their distribution.20 From equations  3-3 and
3-5, the product of equivalent visual  range
and mass concentration (Lvxconc) can be
obtained.
Since
                 3.9
                                      (3-3)
multiplying both sides of the  equation  by
concentration gives
                 3.9 X cone
     LTxconc =	          (3-3a)
                   bgcat
The units on both sides of this equation are
mass per  area (e.g., /xg/m2). If we use the
particular proportionality  in equation 3-5,
then:
Lv x cone-1.2 x 106 /.g/m2 = 1.2 g/m2.  (3-6)
This  product has  a simple physical signifi-
cance: it is the mass of material in a column
of length  Lv and one square meter in  cross
section.  In other words,  it is the amount of
material per  square meter between  the ob-
server and a  point at  the limit of  visibility.
Each point of Figure 3-5 can be used to form
this number since each pair of values of mass
concentration  and scattering coefficient can
       56

-------
   35

   30

   25

   20

   t5

   10

   5-

   0
0  15,
u.
O
E  10
UJ
CO
I  5
z
   0

   5'
w
UJ
   0

   10

   5

   0
                         A. All 238 cases.
                         B. New York City, 62 cases.
                         C. San Jose, California,
                           48 cases.
                         D. Seattle, Washington
                           Area. 45 cases
E. Seattle, Washington, high
  volume air sampler data.
          0.8    1.6    2.4    3.2
                Lv x MASS, grams / m'


FIGURE 3-6. Histogram of Equivalent Visual Range-
  Mass  Concentration  Product at  Several  Loca-
  tions.1*  (The  figure  shows  the  number of cases
  with a given  range  of values of the product of
  mass and equivalent visual range for data at vari-
  ous locations studied. This product represents the
  mass required to  determine  the visibility in a col-
  ume one square meter  in cross  section along the
  light path.)

be used to obtain a  different proportionality
of the sort shown in equation 3-5. Figure 3-6
consists of histograms showing  the number
of  occurrences  for  different values  of the
quantity Lv x cone found at various locations.
Here, since  the modal value is about 1.2
g/m2, one can write:
       LTxconc~1.2:j;2  (g/m2)
to include virtually all cases.
                                        (3-7)
                                                  100:
                        J ioj

                           3

                           1
                                   i   	To  	160
                                    MASS CONCENTRATION,

                        FIGURE 3-7.  Relation Between Visual Range and
                          Mass Concentration.22  (This figure shows the in-
                          verse proportionality between  visual  range and
                          mass concentration described by equations 3-7 and
                          3-8.)

                        Equation 3-5 can also be rewritten to include
                        these upper and lower limits:
                                                   mass (/*g/m3) ~
                                                                          X 105 b9Cat/m. (3-8)
                                                 Data in essential agreement with this result
                                                 have also been  obtained recently by visual
                                                 methods  in Oakland,  California.21  As  the
                                                 data indicate that equation 3-8 is applicable
                                                 in a wide variety  of  cases,20 and  because
                                                 these locations seem to include a wide variety
                                                 of air  pollution character, it is  anticipated
                                                 that  this  generalization may  be useful in
                                                 many urban areas. The relationship is shown
                                                 in Figure 3-7 and Table 3-1. 22 However, ex-
                                                 perimental verification of the mass-light ex-
                                                 tinction relationship is  desirable for  each
                                                 location in question.

                                                 Table 3-1.— RELATION BETWEEN EQUIVALENT
                                                   VISUAL RANGE AND PARTICLE CONCENTRA-
                                                   TIONS
Mass
concentra-
tion jug/m3
10«o
- 5
30^
100«oo
- 60
300^°°
-TBO
1000+10°°
Scattering Equivalent
coefficient visual
due to aerosol, range,
bscat/m km
0.3 X10-4
i.oxio-'
3.3X10-'
lo.oxio-1
33.0X10-'
120.0
40.0
12.0
4.0
1.2
Equivalent
visual
range,
miles
75.00
25.00
7.50
2.50
0.75
                                                                                     57

-------
  The accuracy  of  equations  3-7 and 3-8
depends  on many factors  and assumptions.
This research area is an active one, and new
data are constantly being acquired. Improve-
ments in the understanding of these phe-
nomena and the accuracy of descriptions will
no doubt occur in the near future. However,
these values are known to be accurate to well
within one significant  figure for the  cases
measured, and their utility for criterion pur-
poses is therefore clear.
  Photochemically produced aerosols, as well
as other organic aerosols, can be expected to
have  similar  visibility effects  if their size
distribution  remains  reasonably constant.
Since the physical processes governing size
distribution are  assumed  to be largely in-
dependent of the  chemical nature of the par-
ticles,13 the size distribution should be similar
to those shown in Figure  3-1.  However, if
such  particles are volatile or metastable to
oxidation as  suggested  by  Goetz,23 the mass
determination may be difficult. Although vis-
ibility degradation is evident in photochem-
ical  smog, experimentally  determined size
distribution data  are needed.
  It can be seen  from Figure 3-5 that the
practical unit of  light  scattering coefficient
for 5000 A wavelength is 10~4/m. The value
1 x 10-4/m  represents fairly clean air with a
particle  mass concentration of about  30
jug/m3,  while 10 x 10~4/m  represents  more
polluted  air  (concentration  about 300 /ig/
m3) .  Of course,  the  reciprocal relationship
(equation 3-3) could be used in combination
with equation 3-5.
(Km)~1.2^xl03/conc
                                     (3-9)
 (See also Figure 3-7 and Table 3-1.) How-
ever,  reciprocal relationships are harder to
visualize than are direct  proportionalities,
and the  extinction coefficient due to scatter
 (or  just scattering  coefficient)   itself  can
serve as  an index for particulate pollution.
  It is interesting to compare the results of
equation 3-7 with Robinson's 2 calculation of
0.34 g/m2 for an oil aerosol in which all par-
ticles have the same 0.6/x diameter. Since this
estimate represents a  case in which all the
particles are involved in the light scattering,
it is not  surprising that a mass smaller than
that suggested by equation  3-7 is necessary
for determining the visibility. In the atmos-
phere, a large percentage of the mass of the
particulate matter  is outside the size  class
important for light scatter  (see Figures 3-1
and  3-3)  and a somewhat  higher mass per
unit area is needed to determine the visibility.


F.   DETERMINATION OF  WELL-DEFINED
       CASES OF MASS-VISIBILITY
             RELATIONSHIPS
  As  discussed  above,  any  generalization
about  the visibility-particle (aerosol)  con-
centration  relationship  is  dependent on  a
well-defined  and nearly constant size distri-
bution. The  following  list  summarizes the
cases in which equation 3-8 applies:

     1. the relative humidity should be below
       70 percent.  (For a discussion of the
       relationship between  visibility  and
       concentrations  of sulfur dioxide at
       various  relative  humidities, see  a
       companion volume to this document,
       Air Quality Criteria for Sulfur Ox-
       ides.) Absolute humidity is relatively
       unimportant since the interaction of
       water  vapor and hygroscopic aero-
       sols depends mainly on relative hu-
       midity.  In the case of a particularly
       hygroscopic aerosol, the  70 percent
       figure may  be  unreliable. Table 3-2
       shows a list of compounds  and the
       approximate humidity at which they
       deliquesce. If  such  a  substance is
       present as a large percentage of the
       total  aerosol,  even  though  the rest
       of the following conditions may hold,
       the  applicability  of  equation   3-5
       might be open to doubt.

     2. the size distribution must  be well-
       established and close to the recurring
       form  discussed earlier. Little experi-
       mental  information  is available  on
       the length of time required  for vari-
       ous types of fumes to attain a reason-
       ably  well-defined size distribution by
       coagulation and sedimentation. Meas-
       urement of  this parameter  is there-
       fore  desirable before any generaliza-
       tions  are made about  visibility. The
       58

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Table 3-2.—THE RELATIVE HUMIDITY AT WHICH
PHASE CHAIN UK UCCUKfe
CENT AEROSOLS.24


Substance



Sodium hydroxide
Calcium chloride
Sulfuric acid
Magnesium chloride
Sodium iodide
Magnesium nitrate
Sodium bromide
Potassium iodide
Sodium nitrate
Sodium chloride
Potassium bromide
Potassium chloride
Barium chloride


1JN SUMJi UJiLiHiUffiB-

Approximate
percent relative
humidity at
which phase
change occurs
at 25°C

7
29
35
33
38
53
58
69
74
75
80
84
90



g
Eo
o
b
. * -7
I— i
z
m
I 6
LL
LU
o 5
z
^ 4
m •»
<
8 3
H
O i
— • *
1

0

_
31 AUGUST 1967 K I
1000-1030 PDT \\ I
FOGGY I I I
LOWWINDSPEED / I /
/
/
•*N /
\ I
+'r \
\f\ \
A / \ '\ / ' \
/ \J "" \,' I \
/ 30 AUGUST 19671 l\
*J 1530-161 5 PDT I/ A^
" / HAZE V \ -
/ LOWWINDSPEED \
x 5 SEPTEMBER 196T~ ^v
* 1530-1630 PDT "* 	
STRONG SOUTH WIND— x
,'~\'\ 7 \x

*'"' *"" ^**-_
i i i i i i i i i
       most important qualification appears
       to be  that  the aerosol  in question
       must not  be freshly formed as in a
       smoke  plume. Times of the order of
       one hour  may be adequate for the
       establishment of a well-defined size
       distribution from  a  combustion-pro-
       duced fume.
    3. if visual  observations are used, the
       line  of sight  cannot  pass  through
       smoke   plumes  or  freshly  formed
       clouds  of  fumes. As mentioned ear-
       lier, the light extinction coefficient is
       a spatial variable and  thus the mass
       inferred by  visual  methods repre-
       sents  an  average  over a  large dis-
       tance. If the optical quantity (i.e. ex-
       tinction coefficient due to scatter) is
       to be related to concentration meas-
       urements made at one point in space,
       then it  should be  determined at the
       same point. To illustrate the possible
       magnitude of the visibility variation,
       Figure  3-8  shows  the variation  of
       scattering coefficient measured  with
       an integrating nephelometer across
       the city of Seattle on three days with
       different  meteorological  conditions.
       The results  also emphasize the haz-
       ards inherent in visual observations.25
   20 15  10  5   0   5  10  15  20   25  30
              N       S
     DISTANCE FROM UNIVERSITY HIGH BRIDGE, Km
FIGURE 3-8.  Three Horizontal Profiles Through the
  City of Seattle Taken Under Differing Meteorolog-
  ical Conditions.35  (The figure illustrates the pos-
  sible magnitude of variations in visibility.)

G.   METHODS FOR DETERMINING LIGHT
    SCATTERING COEFFICIENT-MASS
    CONCENTRATION  RELATIONSHIP
  Methods for  determining the  extinction
coefficient and/or the visibility  (as  related
through  equation 3-3)  are  not  as well-es-
tablished as for many meteorological quan-
tities (e.g. wind, temperature)  or for air
pollution quantities  (dustfall, mass concen-
trations, etc.). Three basic approaches can
be differentiated:
     1. the method of choice is an  instantane-
       ous point  measurement  of  the ex-
       tinction coefficient. The extinction co-
       efficient due to scatter (which is as-
       sumed to dominate) can be measured
       with  an  integrating nephelometer
       such  as  was  used  by  Charlson
       et al™> 25>26
    2. the next most desirable methods in-
       volve  the measurement of  total ex-
       tinction coefficient using light trans-
                                                                              59

-------
       mission. Telephotometers  of the
       shortest possible base line  might be
       used, but once again have  poor sen-
       sitivity for typical urban haze. Spe-
       cially devised instruments have been
       designed and used with great diffi-
       culty in the range of extinction found
       in cities. Typical airport  transmis-
       someters are designed to be useful in
       fog and are thus of little value except
       in cases of extreme pollution and fog.
    3. visual  methods,  though frequently
       used, should be  avoided because of
       the subjectivity of the eye  as a sen-
       sor and the variations  between ob-
       servers, as well as the spatial varia-
       tion  problem mentioned above. If  it
       Is necessary to use  visual observa-
       tions, the observers must be methodi-
       cal and should use the rules adopt-
       ed  by  the United  States  Weather
       Bureau.27
  Ordinary methods  (i.e. the  high-volume
air sampler) for the determination of  mass
concentration  (/«g/ni3) may suffice  if care  is
taken to  eliminate spurious large particles
such as insects, etc. As recent data taken in
Seattle show, newer sampling methods using
newer types of niters are becoming available
and allow a much shorter sampling time.

             H.  SUMMARY
  The visual  range,  sometimes called the
"visibility," is reduced by particulate matter
in the air. It refers to the distance at which
it is  just possible  to  perceive and object
against the horizon sky. Both  the attenua-
tion of light from the object and illumination
of the air between the object and the ob-
server tend to reduce visibility, since they
reduce the  perceived  contrast  between the
object and  its background.  Attenuation of
light  passing  through the air results  from
two optical  effects which air molecules and
small particles have on visible radiation: (1)
the absorption of light energy and (2) the
scattering of light out of the incident beam.
In general,  reduced visibility is primarily a
result of  scattering due to particulate mat-
ter. The  "extinction coefficient," bscat, is  a
measure of  the degree of  scattering, and  it
is  related to the visual range of a black ob-
ject as follows:
               3.9
          Lv=	  (m)  .          (3-3)
               bscat
Suspended particulates found in the atmos-
phere cover a broad range of size; however;
the visibility is affected by a relatively nar-
row segment of this size distribution, usually
from about 0.1/i to Ip. radius. Once  particu-
late matter has been suspended in the air for
some  time, the distribution of particles  by
size tends  to take on a typical pattern. Be-
cause of this, and because the visible light
scattering  is caused primarily by particles
of one narrow  size range, the scattering can
be empirically related to the particulate con-
centration. This relationship is as  follows:
        LT~-
            AxlO3
(from 3-9)
where G'=particle  concentration  (ju,g/m3)
       LT = equivalent visual range
        A = 1.2j;-* for LT expressed in kilome-
ters and
           G.751^ for Lv expressed in miles.
The ranges that are shown for the constant,
A,  cover virtually all  cases  studied. Devia-
tions from equation 3-9 would be expected to
occur when the relative humidity exceeds 70
percent,  since  many particles exhibit deli-
quescent behavior and  grow into fog drop-
lets. (For a discussion of the relationship
between visibility and sulfur dioxide concen-
trations at various  relative  humidities, see
a companion volume to this document, Air
Quality Criteria  for Sulfur  Oxides.)  Parti-
cles composed  of sodium chloride, for ex-
ample, would act as  condensation nuclei and
show rapid and large changes  in size under
such  circumstances. Also, this relationship
may not hold for photochemical  smog, since
it is not known whether its size  distribution
conforms  to the  necessary pattern.
  Equation 3-9 provides a convenient means
for estimating the expected visibility for dif-
ferent levels of  particulate  concentrations,
under  the  conditions stated. With a typical
rural concentration  such  as 30  /xg/m3, the
visibility  is  about  25  miles;  for  common
urban concentrations,  such as  100  /ig/m3
and 200 /*g/m3,  the visibility  would be 7.5
       60

-------
miles  and 3.75 miles,  respectively. In  addi-
tion to aesthetic degradation of the environ-
ment,   reduced visibility  has  many conse-
quences for the  safe  operation of  aircraft
and motor  vehicles.  When  airports  have
heavy  traffic,  visibility below 5 miles tends
to slow operations, since  it is  necessary to
maintain  larger distances between aircraft.
Federal air regulations prescribe limitations
on aircraft operating under  conditions of re-
duced  visibility;  they  become  increasingly
severe as the visibility  decreases  from  5
miles  (150 j«g/m3)  to  3 miles  (250 ^g/m3)
to one mile (750 ^g/m3). Based on the empir-
ical variations in equation 3-9, the same vis-
ibilities could occur under  certain  circum-
stances, at concentrations one-half of these
calculated values. Thus, a concentration of
75  jug/m3 might produce a visibility  of  5
miles in some instances.


              I.   REFERENCES

 1.  Holzworth,  G. C.  "Some Effects of Air  Pollu-
    tion on Visibility  in and near  Cities."  In:  Air
    Over Cities  Symposium, U.S.  Dept. of Health,
    Education, and  Welfare, Robert  A.  Taft Sani-
    tary Engineering Center, Cincinnati,  Ohio, Tech-
    nical Report A62-5, 1961, pp. 69-88.
 2.  Robinson, E. "Effects  of Air Pollution on Visi-
    bility."  In:  Air Pollution,  Chapt  11, Vol. 1,
    2nd edition, A. C.  Stern (ed.),  Academic Press,
    New York, 1968, pp. 349-400.
 3.  Middleton, W. E. K. "Vision Through the Atmos-
    phere." University of Toronto Press, 1952.
 4.  "Federal  Aviation Regulations."  Federal  Avia-
    tion Agency, 1967.
 5. "A  Study of Pollution—Air."  A staff report
    to the Committee on Public Works, U.S. Senate,
    Washington, D.C.,  1967.
 6.  "New York-New Jersey Air Pollution Abatement
   Activity,  Phase  II—Particulate  Matter."  U.S.
    Dept. of  Health, Education,  and Welfare,  Na-
   tional  Center for Air  Pollution Control, Wash-
   ington,  D.C., 1967.
 7. "Kansas  City,  Kansas-Kansas  City,  Missouri,
   Air  Pollution Abatement Activity,  Phase II—
    Pre-conference  Investigations."   U.S.  Dept.  of
   Health, Education,  and Welfare, National Cen-
   ter for  Air Pollution Control, Washington, D.C.,
   March 1968.
 8. Angstrom, A. K.  "On the Atmospheric Trans-
   mission of Sun Radiation  II."  Geograph. Ann.
    (Stockholm), Vol.  12,  pp.  139-159, 1930.
 9. Junge, C. E.  "Air Chemistry and  Radioactivity."
   Academic Press, New York, 1963.
10. Conner, W.  D.  and Hodkinson, J. R. "Optical
    Properties and  Visual Effects of  Smoke-Stack
    Plumes." U.S. Dept. of Health, Education, and
    Welfare, National Center for Air Pollution Con-
    trol, PHS-Pub-999-AP-30, 1967.
11. Went, F. W. "Dispersion and Disposal of Or-
    ganic  Materials in the Atmosphere." Preprint
    Series  31,  University  of Nevada,  Desert Re-
    search Institute, 1966.
12. Pilat,  M. J. and  Charlson, R. J.  "Theoretical
    and Optical  Studies of Humidity Effects on the
    Size Distribution of a  Hygroscopic Aerosol." J.
    Rech. Atmospheriques, Vol. 2,  pp. 165-170,  1966.
13. Charlson, R. J., Horvath, H., and Pueschel, R. F.
    "The Direct  Measurement of Atmospheric Light
    Scattering Coefficient  for  Studies  of Visibility
    and Air Pollution."  Atmos.  Environ., Vol. 1,
    pp. 469-478,  1967.
14. "California  Standards for Ambient Air Quality
    and Motor Vehicle Exhaust—Technical Report."
    Dept.  of Public Health, Berkeley,  California,
    1960.
15. Friedlander,  S. K. and Wang, C. S.  "The  Self-
    Preserving  Particle Size Distribution for Co-
    agulation by Brownian Motion."   J.  Colloid In-
    terface Sci.,  Vol. 22, pp. 126-132,  1966.
16. Whitby, K. T. and Clark, W. E.  "Electric Aero-
    sol  Particle  Counting  and  Size  Distribution
    Measuring  System  for the   0.15^ to 1/j.  Size
    Range." Tellus, Vol. 18, pp. 573-586, 1966.
17. Peterson, C. M.  and Paulus,  H. J.  "Microme-
    teorological  Variables  Applied to the Analysis
    of Variation in Aerosol Concentration and Size."
    Preprint. (Presented at the 60th Annual Meet-
    ing, Air Pollution Control Association, Cleve-
    land, Ohio, June 11-16,1967.)
18. Mie,  G. "Beitrage  zur Optik triiber Medien,
    Speziell   Kolloidaler   Metallosungen."    Ann.
    Physik, Vol. 25, pp. 377-455, 1968.
19. Pueschel, R.  F. and Noll, K. E.  "Visibility and
    Aerosol  Size Frequency Distribution." J. Appl.
    Meteorol, Vol. 6, pp. 1045-1052, 1967.
20. Charlson, R.  J., Ahlquist, N. C., and Horvath, H.
    "On the Generality  or Correlation  of  Atmo-
    spheric Aerosal Mass  Concentration  and Light
    Scatter." Atmos. Environ., Vol. 2, pp. 455-464,
    1968.
21. Noll, K. E., Mueller, P. K., and Imada, M. "Visi-
    bility and Aerosol Concentration in Urban Air."
    Atmos.  Environ., Vol. 2, pp. 465-475,  1968.
22. Charlson, R.  J.  "Atmospheric Aerosol Research
    at the University of Washington." J. Air Pol-
    lution Control Assoc., Vol. 18,  pp. 652-654, 1968.
23. Goetz,  A., Preining,  O.,  and Kallai, T.  "The
    Metastability of Natural  and  Urban  Aerosols."
    Rev. Geofis.  Pura Appl. (Milano), Vol. 60, pp.
    67-80,  1961.
24. Acheson, D. T.  "Vapor Pressures of Saturated
    Aqueous Salt Solutions."  Proc. Intern.  Symp.
    Humidity and Moisture, Washington,  D.C.,  May
    1963, pp. 521-530.
                                                                                         61

-------
25.  Ahlquist, N. C. and  Charlson, R. J. "Measure-        Air."  J.  Air Pollution Control Assoc.,  Vol. 17,
    ment of the Vertical and Horizontal Profile of        pp. 467-469, 1967.
    Aerosol  Concentration in Urban Air with the
    Integrating Nephelometer."  Environ. Sci. Tech-    27.  "Manual  of Surface  Observations  (WBAN)."
    nol., Vol. 2, pp. 363-366,1968.                           Circular  N, 7th  Edition  (Revised  to include
26.  Ahlquist, N. C. and Charlson, R. J.  "A New In-       changes  1 through 14), U.S.  Weather  Bureau,
    strument for Evaluating the Visual Quality of       January 1968.
        62

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             Chapter 4
     EFFECTS OF ATMOSPHERIC
PARTICULATE MATTER ON MATERIALS

-------
                         Table of Contents
                                                                  Page
A. INTRODUCTION                                                 65
B. EFFECTS OF PARTICULATE MATTER ON METALS               65
C. EFFECTS OF PARTICULATE MATTER ON BUILDING
   MATERIALS                                               .     69
D. SOILING AND DETERIORATION OF PAINTED SURFACES         71
E. SOILING AND DEGRADATION OF TEXTILES                     71
F. SUMMARY                                                      72
G. REFERENCES   ,                     .          	     74

                           List of Figures
Figure
4-1  Plot of Rate of Rusting Versus Dustfall at Four Locations             66
4—2  Weight Loss from Zinc Specimen as a Function of Exposure Time .      67
4-3  District Building, Washington, D. C.                                67

                           List of Tables
Table
4-1  Corrosion of Open-Hearth Iron Specimens in Different Locations        66
4-2  Corrosivity of Atmospheres towards Steel and Zinc at Selected Loca-
     tions Relative to that at State College                 .        .     68
4—3  The Corrosion Rates of Metals in Various Locations                   70
 64

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                                      Chapter 4

   EFFECTS  OF ATMOSPHERIC PARTICULATE  MATTER  ON MATERIALS
           A.  INTRODUCTION
  Airborne particles may damage surfaces
merely by settling on them. A light deposit of
dust makes surfaces appear dingy, and the
frequent cleaning necessary in a dusty atmos-
phere  weakens materials and costs money.
  Particles can also cause direct or chemical
deterioration of materials.  The nature and
extent of the deterioration depends  on the
chemical activity of the particles in their en-
vironment  and the relative susceptibility of
the receiving material. Particles may cause
chemical deterioration  either  by  acting  as
condensation nuclei for the retention of ad-
sorbed gases or harmful acids, or by their
own innate corrosive action.
  In the following  sections it will be seen
that particulate air pollution plays an  impor-
tant role in the corrosion of  metals;  in the
soiling, damage, and erosion of coatings and
painted surfaces,  building stones, marble,
and other building materials; and in the soil-
ing and degradation of textiles.

B.  EFFECTS OF PARTICULATE MATTER
              ON  METALS
  Atmospheric particles may  accelerate the
corrosion of iron, steel, and various nonfer-
rous metals.
  Metals are generally resistant to attack in
dry air,1 and even  clean moist air does not
cause significant corrosion.1-2  Furthermore,
inert dust  and soot particles without sulfur
compounds as constituents do not of them-
selves  cause  marked corrosion.1-3 Particles
may, however, contribute to accelerated cor-
rosion  in two ways.4 First,  they may be in-
trinsically active, and secondly, although in-
active,  they may be capable of absorbing or
adsorbing active gases  (such  as S02) from
the atmosphere.
   Those particles  which are  inactive and
have  negligible capacity for absorption  or
adsorption have little effect other than that
of acting as droplet nuclei in the atmosphere.
For example,  silica particles do not acceler-
ate the rate of metal corrosion even in the
presence of S02. On the other hand, char-
coal  (carbonaceous)  particles  in  atmos-
pheres  with relative humidities below 100
percent cause  a large increase in the rate of
corrosion in the presence of S02 traces, pre-
sumably through the local concentration  of
the gas by adsorption.4  The laboratory re-
search which led to these findings was based
on particulate concentrations of 0.4 mg/cm2
(equivalent to 0.3 tons/mi2) and abnormally
high S02 concentrations  of 100 ppm.
  Active hygroscopic particles such as sul-
fate and chloride salts and sulfuric acid aero-
sol serve as corrosion nuclei. Their presence
in the atmosphere can initiate corrosion, even
at low relative humidities.5 Laboratory stud-
ies of  bare and varnished steel test panels,
properly polished  and degreased, and then
inoculated  with finely divided  particles  of
various substances such as  are commonly
found in the atmosphere, were conducted by
Preston and Sanyal.5 Particles of chloride,
sulfate, chromate, and oxide salts, and boiler
and flue dusts  were used. The metal test pan-
els  were exposed  to atmospheres  of pure
clean  air and  of air containing S02 at vari-
ous humidities, and the  resulting corrosion
was measured. Filiform corrosion, character-
ized by a  filamental configuration,  the pri-
mary  phase in electrolytic  corrosion,  was
noted in all cases.  Corrosion rates  are low
when  the relative humidity is below 70 per-
cent,  but  they increase  at higher  humidi-
ties.4- e In  most of  the cases in this study,
corrosion increased with  increased humidity
even in clean  air. The addition of traces of
                                                                              65

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S02 to the test atmosphere greatly increased
the rate of corrosion in all instances.5
  Field experiments show that the rate  of
corrosion of various metals is accelerated in
urban and  industrial areas because  of the
greater atmospheric concentrations of both
particulate  matter  and sulfur  compounds.
Standardized  open-hearth iron  specimens,
after exposure for one year at  a number  of
diverse locations throughout the world, were
observed  by Hudson7  to  have  a manifiold
variation  in weight loss. Iron specimens ex-
posed for one year to desert and arctic en-
vironments, the least polluted  areas, were
the  least  corroded,  i.e.,  had  the smallest
losses in weight. Those speimens exposed at
heavily-polluted urban  industrial sites were
the  most  corroded,  more so than  similar
specimens exposed at many marine and trop-
ical locations, Table 4-1. Hudson, Figure 4-1,
also correlated  the rate of  rusting of mild
steel specimens and dustfall  levels for four
diverse areas, from a heavily industrialized
area in Sheffield, England, to  a rural area
(Llanwrtyd Wells). The iron specimens cor-
roded four times as fast in the polluted in-
dustrial atmosphere as they did in the rural
atmosphere.
  Committee  B-3  of the  American Society
of Testing Materials (ASTM)8'9 studied cor-
UJ
5
   2
CC
U.
o
UJ  1
<
cc

   OJ
                             SHEFFIELD
           WOOLWICH

      CALSHOT

LLANWRTYD WELLS
         16     32     48     64     80

           DUST FALL, TONS / Ml2- MONTH
                            96
 FIGURE 4-1.  Plot of Rate of Rusting Versus Dust-
   fall at Four Locations.7  (The figure plots the rate
   of rusting of mild steel versus dustfall, and shows
   that corrosion is  four times as rapid in an in-
   dustrial  area (Sheffield) as it is in the rural area
   (Llanwrtyd Wells)).

 rosion rates of steel and zinc panels exposed
 for one year at several locations in the United
 States. The relative corrosivities of various
 atmospheres  at 19 sites were compared to
 that of the rural site of State College, Penn-
 sylvania,  which was used as a base. This
 study  (Table 4-2)  confirms Hudson's ob-
 servations that  industrial  locations  with
    Table 4-1.—CORROSION OF OPEN HEARTH IRON SPECIMENS IN DIFFERENT LOCATIONS.7
Location
Khartoum, Sudan
Abisko, North Sweden
Aro, Nigeria
Singapore Malaya
Basrah Iran
Apapa, Nigeria - -
State College Pa , USA
Berlin Germany
Llanwrtyd Wells British Isles
Calshot British Isles
Sandy Hook N J USA

Motherwell British Isles

Pittsburgh Pa USA
Sheffield Univ British Isles
Derby South End, British Isles
Derby North End, British Isles
Frodineham. British Isles. — _
Type of atmosphere
Dry inland, . __ . _ .
Unpolluted
Tropical inland
Tropical marine
Dry inland
_ Tropical marine _ . . 	 _.
Rural
Semi-industrial
Semi-marine . 	 _ ____
Marine
Marine-scmi-industrial
Marine
Industrial
Industrial
Industrial
Industrial _ _
Industrial
Industrial
. . _ _ Industrial 	 	 	 	 	
Annual
weight
loss, g
	 0.16
0.46
1.19
1.36
1.39
	 2.29
3.75
4.71
	 5.23
6.10
7.34
7.34
8.17
8.91
9.65
	 11.53
	 12.05
	 12.52
	 14.81
Relative
corro-
sivity
1
3
8
9
9
15
25
32
35
41
50
50
55
60
65
78
81
84
100
       66

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 high concentrations of particles and of ox-
 ides of sulfur are more corrosive to steel and
 zinc than less industrialized areas.  As shown
 in Table 4-2, steel specimens corroded in one
 year approximately  3.1  times as much  in
 New York  City (spring exposure)  and 3.3
 times  as  much in  Kearny, New Jersey,  as
 similar specimens at State College, Pennsyl-
 vania. Zinc specimens  corroded 3.6  and 2.6
 times as much in New York City (spring ex-
 posure)  and Kearny respectively, as similar
 specimens exposed  at State  College.  Both
 steel and zinc specimens in New York  City
 (fall exposure  when  the particle and  S02
concentrations in the atmosphere are greater
than in spring) corroded 6.0 and 3.7 times as
much respectively as similar steel and zinc
speciments at Sate College.8 The authors of
the resulting papers did not give mean con-
centrations of suspended particulate matter
for the various locations; but  approximate
concentrations, based on  NASN  measure-
ments 10 made after the corrosion studies, are
given here. Based on Table 4-3, a  town the
size of State College, Pa., could  have a mean
suspended particulate-matter level of 60 //,g/
m3 to  65 /xg/m3.  The mean suspended par-
ticulate  matter  concentrations were  176
   Table 4-2.—CORROSIVITY OF ATMOSPHERES TOWARDS STEEL AND ZINC AT SELECTED
           LOCATIONS RELATIVE TO THAT AT STATE COLLEGE, PENNSYLVANIA.8
              Location
Type of atmosphere
Relative corrosivity
of one-year test for
                                                                          Steel
                                    Zinc
Norman Wells, N.W.T., Canada _
Esquimalt, Vancouver Is., Canada __ __
Saskatoon, Sask., Canada _ -
Perrine, Fla ... _ _ _____
State College, Pa 	 	 	
Ottawa, Canada
Middletown, Ohio_
Trail, B.C., Canada 	
Montreal, Que., Canada _ __ . _ _
Halifax, N.S., Canada 	
South Bend, Pa 	
Kure Beach, N.C., 800-ft site 	
Point Reyes, Calif 	 	
Sandy Hook, N. J _ _ _
New York, N.Y. (spring exposure)
Kearny, N. J _______
Halifax, N.S., Canada__ _ __ _
New York, N.Y. (fall exposure) _
Daytona Beach, Fla
Kure Beach, N.C., 80-ft site 	 	
Polar-Rural ._ .
Rural-Marine a___ _ 	
	 Rural 	
	 Rural 	
Rural 	
Semi-Rural - - - _ _
Semi-Industrial __
_ . Semi-Rural . _ __ 	 __
... Industrial 	 	 	 	 .
Rural-Marine 	 _ _ .
Semi-Rural . _ _
Marine (800 ft from ocean) _ _
Marine _ _ _
Industrial-Marine _ _ _ _
Industrial - _ ,
Industrial-, ____ __. ___ 	
Industrial-Marine b _ _
Industrial
Marine _. . _
Marine (80 ft from ocean). __ _._ _.
	 0.03
	 0.5
	 0.6
	 0.9
	 1.0
1.0
1.2
1.4
	 1.5
	 1.5
	 1.5
1.8
1.8
2.2
	 3.1
	 3.3
	 3.8
	 6.0
	 7.1
13.0
0.4
0.4
0.5
1.0
1.0
1.2
.9
1.6
2.2
1.6
1.5
1.7
1.8
1.6
3.6
2.6
18.0
3.7
2.6
5.7
   a While test site is 1500 ft. from brackish water, prevailing winds are from inland and prevent deposition of salt
water spray.
   b Test site is near a smokestack; prevailing winds blow fumes over the test site.

           Table 4-3.—THE  CORROSION RATES  OF METALS IN VARIOUS LOCATIONS.9

                                                              Corrosion rate, mil/year
Test Site


Altoona, Pa. (Heavy industrial-R.R.)
New York, N.Y. (Urban-industrial)
State College, Pa. (Rural-farm) .
Phoenix, Ariz. (Rural-semiarid)

Nickel
200
.. . . 0.222
0.144
0.0085
0.0015

Monel
alloy 400
0.076
0.062
0.007
0.002

Copper

0.055
0.054
0.017
0.005
                                                                               67

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       in New York City and 131 ng/m3 at
Elizabeth, New  Jersey,  near Kearney,10 it
should be pointed out that there are signifi-
cant differences in levels of gaseous pollution,
particularly  sulfur  dioxide,  between  State
College and  the  larger industrial communi-
ties. Consequently, the differences in corro-
sion rates cannot be solely attributed to the
effects of particulates.
  In Chicago and St. Louis, steel panels were
exposed at a number of sites, and measure-
ments were taken of corrosion rates and of
levels of sulfur dioxide and particulates.11 In
St.  Louis, except for one exceptionally pol-
luted site, corrosion losses correlated  well
with sulfur  dioxide levels, averaging 30 per-
cent to  80  percent  higher than  corrosion
losses measured in nonurban locations. Over
a 12-month  period in Chicago, the corrosion
rate at the most corrosive site (mean S02
level  of  0.12 ppm)  was  about 50 percent
higher than at the least corrosive site  (mean
S02 level of 0.03 ppm). Sulfation rates in St.
Louis, measured by lead  peroxide candle,
also correlated well with weight loss  due to
corrosion.  Although suspended particulate
levels measured in Chicago with high-volume
samplers  correlated with  corrosion rates, a
covariance analysis  indicated that sulfur di-
oxide concentrations had the dominant in-
fluence on corrosion. Measurements of dust-
fall in St. Louis, however, did not correlate
significantly  with corrosion rates.  Based on
these data, it appears that considerable cor-
rosion may take place (i.e., from 11 percent
to 17 percent weight loss in 'steel panels) at
annual average sulfur dioxide concentrations
in the range of 0.03 ppm to  0.12 ppm, and
although high particulate levels tend to ac-
company high sulfur dioxide levels, the sul-
fur dioxide concentration  appears to have the
more important influence.
  Comparative studies of the rates of cor-
rosion of zinc-coated steel panels exposed
to various community atmospheres were con-
ducted by Committee B-3 of the ASTM.9 The
corrosion rates of zinc at four of the loca-
tions  over a  six-year period are shown in
Figure 4-2, as weight loss versus time. For
each location, the corrosion rate is essential-
ly constant with time. The  atmosphere  of
New York City  with greater concentration
                       NEW YORK CITY
                        (INDUSTRIAL)
                           A  KEARNY, N.J.
                               (INDUSTRIAL)
                234
                EXPOSURE, YEARS
FIGURE 4-2.  Weight Loss from Zinc Specimen as a
  Function of Exposure Time.8  (The figure shows
  the rate of corrosion of zinc at four locations in
  the United States, and indicates that corrosion is
  more rapid in industrial areas.)

of particles  and sulfur  oxides  produces a
steeper  rate  of corrosion of zinc than that
of Kearny, New Jersey, which is also heavily
polluted.  Zinc corrodes  at a greater  rate
in both industrial  communities than in the
rural or  semirural  sites  in South Bend,
Pennsylvania,  and State College, Pennsyl-
vania.8
  Studies of the effects  of  air pollution on
the atmospheric corrosion of three  metals
(nickel  200,  Monel alloy 400, and copper)
exposed to four diverse atmospheres  (heavy-
industrial, urban-industrial, rural-farm, and
rural-semiarid) were  conducted over  a 20-
year period.9 Nickel 200 is 99.5 percent nickel
and Monel 400 is essentially 30 percent cop-
per  and  70  percent  nickel. Though  these
metals are relatively  corrosion-resistant, it
will be noted  from Table 4-3 that they are
       68

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corroded  more in  industrial  atmospheres
than in rural ones. However, because of the
corrosion resistance of the metals, all of the
rates are relatively low when  compared to
those for unalloyed iron or steel. In the  in-
dustrial  locations, nickel  200  corroded  at
rates two to four times greater than Monel
(nickel-copper) alloy 400, while in the rural
locations, its corrosion rate was about equal
to that of Monel alloy 400, and only one-half
the rate for copper. Even  Monel 400, with
its superior corrosion resistance, when used
as a gutter in an  industrial installation, be-
came pitted when the soot was  permitted to
accumulate.9 Unburned  carbon in the soot
led to the formation  of local galvanic cor-
rosion cells. The result was premature per-
foration  and accelerated attack of the metal
sheet.
   Larrabee12  confirmed that the  corrosion
resistance of steel  is greatly improved by the
addition  of  small amounts of copper, or low
alloys of chromium, nickel, copper, and phos-
phorus.  The  additional  cost of such alloy
steels  when they  are used  to resist atmos-
pheric corrosion is attributable to air pollu-
tion.
   Particles  can cause corrosion  of electronic
gear of all types even where pervious metals
are used to minimize such corrosion. Elec-
trical instruments and electronic components
are factors of  growing importance in the
computer and missile  industries,  and also
monitor  and  control an  increasingly large
share of manufacturing processes.13  Oily or
tarry particles, commonly found in industrial
and urban areas,  are  serious factors in the
corrosion and failure of  electric contacts,
connectors, and components.13
   Dust can act mechanically or chemically on
electric contacts. It can  deposit on  the sur-
faces  and  interfere with  electrical  contact
closure, it can become imbedded in the sur-
faces  of  contacts,  or it can induce wear  by
abrasion if the contacts  slide.13-14  Hygro-
scopic  dusts,  accumulated on contacts, will
absorb water  to form thin electrolytic films
which  are  corrosive to base metals.5  If the
contact members are  not of  identical com-
position,  galvanic  corrosion may occur. The
tarnish and corrosion films impair or cause
failures in electrical conductivity, and can be
avoided or minimized only by fabricating the
electrical contacts out of nonreactive metals,
by encapsulation, or by air purification de-
vices such  as filters or by gas-absorbing
chemicals. Any of these solutions to the prob-
lem increases costs.

C.   EFFECTS OF PARTICULATE MATTER
       ON  BUILDING MATERIALS
   Building materials and surfaces are soiled,
disfigured, and damaged by  atmospheric  par-
ticles.  Some of  these  stick to surfaces of
stone,  brick,  paint, glass,  and composition
materials, forming a film of tarry soot and
grit which may  or may not be removed by
the action of the rain. The  result is a dingy,
soiled  appearance  (Figure  4-3), a  loss in
aesthetic attractiveness- and, in many cases,
a physical-chemical degradation or erosion of
these surfaces.
  In cities  where large  quantities of soot-
providing fuel are  burned, the problem is
particularly severe.  Much money  and effort
have been spent on sandblasting off the sooty
layers which have accumulated on prominent
buildings in  burning  soot-producing  fuel
cities.15^17 The tarry substances or carbona-
ceous material resulting from inefficient com-
bustion of soot-producing fuel  are likely to
be sticky and also acidic;2 if not flushed off
by rain they will adhere to surfaces and  cor-
rode them over extended periods of time.18
Smoke particles may also act as a reservoir
for adsorbed gases, such as S02, and harmful
acids, including sulfurous, sulfuric, and hy-
drochloric acids,  as well as  hydrogen sulfide.
These  materials  cause the  deterioi ation of
many of  the  less resistant tyes ol°  mason-
ry_19, 20
  Buildings  in  polluted  areas  bee ime  un-
sightly quickly and require periodic cleaning
and maintenance to remove the t irry as-
phalt-like deposits. In  Washington  D.C.' it
was found necessary to clean the si loke and
grime from the new Supreme Court building
even before  initial occupancy  (in "he mid-
thirties).16 While the soiling effect < f soot is
by far the most evident to the eye, il does not
in itself  cause the deterioration oi building
material.  The  destruction  is due to acids
alone or  to  acids  adsorbed on particulate
matter.
                                                                               69

-------
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70

-------
 D.  SOILING AND DETERIORATION  OF
          PAINTED SURFACES

   Painted  surfaces, walls, and  ceilings of
 homes and other buildings are soiled by tarry
 and  other particulate  substances  in the at-
 mosphere. Furthermore, there are both liq-
 uid  and solid particles  present in polluted
 air in the form of fumes and mists of vary-
 ing  chemical composition  which react  with
 painted surfaces.18-21 The damage done is
 both aesthetic and  material,  and may affect
 not  only buildings  but  also  paintings  and
 other works of art.
   Auto finishes  have  been observed to be-
 come pitted  and stained  by iron particles
 deposited on them from a metal grinding op-
 eration nearby,6-22  while chromic acid  mist
 from an electroplating operation formed  a
 brown  stain on  light  colored  cars  and  a
 "blushing" on darker shades of paint.  Re-
 painting was  required  because  the color
 changes were not reversible by washing or
 polishing.18-23 Cars  parked near demolition
 operations of brick buildings have been se-
 verely damaged by alkali mortar dust in the
 presence of moisture.18 Characteristic pitting
 of painted surfaces is also caused by sodium
 carbonate  particles from  such  industrial
 processing as soda ash manufacture.
   Water  soluble chlorides  and  sulfates—
 mostly the  iron, copper, calcium,  and zinc
 salts—are  commonly  found  in  particulate
 samples from cities21'23-24 and in rainwa-
 ter.23 These water-soluble  particles are po-
 tential  sources  of osmotic  blistering  of
 painted surfaces. The  effects  on weathering
 by small quantities of such  particles have
been  examined 21 during  laboratory studies
 of accelerated aging of various paint panels.
 The  presence of 0.1 ppm  of iron in the water
 in the  accelerated  weather  apparatus  pro-
 duced yellow staining,  while 0.5 ppm of cop-
 per produced severe brown staining. These
 same effects may be expected on natural ex-
 posure.21
   Dust particles settling on wet varnish and
paint films produce  visible imperfections and
 reduction  in the  electrical  resistance  and
anticorrosive properties  of such films.25 In
laboratory tests to  examine the relationship
to corrosion of dust particles under the pro-
tective  coatings, two  sets  of  metal panels
were coated with a varnish formulation un-
der a "dust-free" apparatus, and then one set
was removed from the apparatus so that the
varnish films dried in contact  with the lab-
oratory air. The panels were then immersed
in 3 percent  aqueous  sodium chloride for
seven and  one-half months. Where the var-
nish film had dried in "normal" laboratory
room air,  considerable rusting occurred  on
the panels after six months of immersion; no
corrosion occurred on the panels dried in the
"dust-free" environment. Clearly  the  dust
particles that settled on the  films  of the pan-
els  during the  drying period  were a pre-
dominant factor in initiating corrosion of the
metal.25
  The exteriors of buildings  in industrial
areas,  when  repainted,  collect  numerous
black specks on their surfaces even before
the  paint  has  dried.26  Within two  to  four
years- depending on the  degree  of  particle
concentration, these building  exteriors  are
distinctly  soiled and require repainting.16-26

    E.  SOILING AND DEGRADATION
              OF  TEXTILES
  Soiling  of clothing,  curtains,  and other
textiles not only diminishes their  aesthetic
appeal but also  reduces their functional ef-
fectiveness. A  garment which soils  readily
will  not have the  same user appeal as one
which does not,  even though its performance
may be equal in other respects. Economic
costs are therefore involved both in the extra
cleaning of garments which soil readily and
in the development and manufacture of soil-
resistant textiles.
  The extent of soiling of  textiles,  such  as
curtains, is influenced  by various external
factors such as temperature, relative humid-
dity,  and  wind  speed- and  the specific size
and  characteristics of the atmospheric par-
ticles. In addition, the degree of soiling is de-
pendent on the construction  and finish of the
textile material  and the type of  fiber from
which it is  made.27
  When large particles are  deposited on the
surface of the  textile, the  soiling  may  be
superficial. In moving air, however, the par-
ticles may be directly intercepted by the indi-
vidual fibers or may be thrown onto the fibers
                                                                              71

-------
as air sweeps through the intricate channels
between them, i.e., the material behaves as a
filter. The soiling of curtains and flags is an
illustration of this effect. Airborne particles
can also affect the cleanliness of yarns and
fabrics  during their manufacture. Economic
loss to textile manufacturers can occur unless
suitable air filters are used in manufacturing
plants.27 Laboratory studies by Rees,27 using
a dust circulating apparatus under controlled
conditions; show that a closely woven fabric
of low  porosity  best resists soiling  by air-
borne particles.
  If an exposed textile material acquires an
electrostatic charge, for example by friction,
and is able to retain its charge, charged par-
ticles of opposite sign will be attracted to it,
thereby increasing its rate of soiling.27 Cel-
lulose acetate and some of the synthetic tex-
tiles acquire, by friction during spinning and
weaving,  electrostatic  charges which, be-
cause of  the  high insulating  properties of
these materials, are  retained for a long peri-
od of time. This results in troublesome "fog-
marking," caused by attraction of airborne
particles to the charged textile.27
  In laboratory investigations  of the electro-
static attraction of airborne particles to cot-
ton textiles, Rees 27 found that soiling is more
rapid when the fabric is  charged than when
uncharged,  and  that the rate of soiling  is
increased by  raising the  applied electric po-
tential  (which increases  the charge density
on the fabric).  For any given potential, the
rate of soiling appears to be  greater for a
positively charged fabric specimen than for
a negatively charged one.
  The vulnerability  of textile fabrics and
furnishings to the acid components  of  par-
ticulate matter depends on the chemical com-
position  of the  textiles.28  Cellulosic fibers,
such as cotton,  linen,  hemp, jute, and man-
made rayon are  particularly sensitive to at-
tack from such substances as  sulfurous and
sulfuric acids, while animal fibers,  such as
wool  and furs, are more resistant  to  acid
damage.28
  Curtains are particularly vulnerable to air
pollutants and  often deteriorate  quickly
hanging at  open windows; soiling occurs to
some extent even when windows are closed.
The curtain material acts more or less  as a
filter for acid-laden dust and soot.  Airborne
metallic iron and zinc particles, constituents
of city dust,23- 28> -g  are catalysts  and pro-
mote oxidation of sulfur dioxide to sulfuric
acid, which may contribute to textile degra-
dation.  Curtains weakened by conditions of
exposure  arising  partly from atmospheric
soiling and acidity give way in a character-
istic manner  by splitting  in  parallel  lines
along the folds  where the  greatest number
of particles accumulated.

              F.   SUMMARY

  Airborne particles—including soot,  dust,
fumes,  and mist—can,  according to  their
chemical  composition  and  physical  state,
cause a wide range of damage to materials.
They  may  cause deterioration  merely  by
settling on  surfaces  and soiling  them thus
creating a  need for  more frequent  clean-
ing which in itself weakens materials.  More
importantly, they can cause  direct chemi-
cal damage to materials in  two ways:  First,
through  their own  intrinsic  corrosiveness,
and secondly, through the action of corrosive
chemicals  which they may have absorbed
or  adsorbed. Airborne  particulates  have
been implicated in the  corrosion of metals
and metallic surfaces; in the soiling,  dam-
age, and  erosion of buildings and   other
structures; in the discoloration and destruc-
tion of painted surfaces; and in the aesthetic
degradation  and  damage  of  fabrics  and
clothing.
  Metals  ordinarily  can  resist corrosion in
dry air alone, or even  in  moist clean air.
Even inert dust or  soot, in the absence of
active  chemical  agents-  has little effect on
metal surfaces.  However,  hydroscopic par-
ticles commonly found in the atmosphere can
corrode metal surfaces although  no  other
pollutants may be present.  This was shown
in laboratory studies  in which  steel test pan-
els were dusted with various common par-
ticulates.  Although corrosion rates were low
at relative humidities under 70 percent, they
tended to increase with increased humidity.
The addition  of sulfur  dioxide  to  the lab-
oratory air greatly accelerated the rates of
corrosion.
  In general,  there is an increasing rate of
corrosivity as we  go  from  dry, unpopulated
       72

-------
environments,  the least  polluted areas, to
heavily polluted urban industrial sites. Sam-
ples of iron, for example, have shown weight'
loss due  to corrosion that  is four times
greater in  industrial  atmospheres  than in
rural atmospheres.  Steel  samples corroded
in one year 3.1 times as much in New York
City (spring exposure), where  the  particu-
late concentration was 176 /«g/m3, as in the
rural atmosphere of  State  College, Penn-
sylvania,  where  the   mean  concentration
could be expected to range about 60 /ig/m3
to 65 /ig/m3. Steel samples exposed in  New
York in the fall of the year,  when the par-
ticulate and sulfur dioxide levels are higher
than in the spring,  corroded  6  times faster
than the samples at State College.  Similarly,
zinc samples exposed in New  York corroded
about 3.6 times as much as  those at State
College, while  zinc samples at Kearny,  New
Jersey,  corroded about 2.6 times as much
(the concentration was 131 /*g/m3 at Eliza-
beth, New Jersey, near Kearney).
  It should  be concluded, however, that the
variation in corrosion rates referred to above
are  due only  to  differences  in particulate
matter, since  there are  significant differ-
ences in gaseous pollutant concentrations be-
tween  State College and  the other areas.
Even highly resistant metals  have shown
corrosion  rates  which  are  progressively
larger  over  the following range of environ-
ments;  (1)  a  rural semiarid  site;  (2)  a
rural farm  enviornment;  (3) an  urban in-
dustrial area;  (4)  a heavy industrial area.
In Chicago  and St. Louis, steel  panels were
exposed at a number of sites, and measure-
ments were taken of corrosion rates and of
levels of sulfur dioxide and particulates.  In
St.  Louis, except for one exceptionally pol-
luted site, corrosion losses correlated  well
with sulfur  dioxide levels, averaging 30 per-
cent to 80  percent higher than  corrosion
losses measured in nonurban locations. Over
a 12-month  period in Chicago, the corrosion
rate at the  most corrosive site (mean S02
level of 0.12  ppm)  was  about 50  percent
higher than  at  the least corrosive site (mean
S02  level  of 0.03 ppm).  Sulfation rates in
St. Louis,  measured by lead peroxide candle,
also  correlated well with weight loss due to
corrosion.   Although suspended particulate
levels  measured  in  Chicago with high-vol-
ume  samplers  correlated  with  corrosion
rates,  a covariance analysis indicated that
sulfur dioxide concentrations had the domi-
nant influence on corrosion. Measurements
of  dustfall  in  St.  Louis, however, did not
correlate  significantly with corrosion rates.
Based  on these data, it appears that consid-
erable corrosion  may take place  (i.e.,  from
11 percent to 17 percent weight loss in steel
panels)  at  annual  average sulfur  dioxide
concentrations in the range  of 0.03 ppm to
0.12 ppm, and although high particulate lev-
els  tend to accompany high sulfur  dioxide
levels,  the sulfur dioxide concentration ap-
pears to have the more important influence.
  Particles  play  a  significant role in corro-
sion and damage to electronic  equipment of
all  kinds,  even when  precious  metals are
used to minimize such effects.  The contacts
in electrical switches are vulnerable to chem-
ical or mechanical  action  by particulates.
The particulates  commonly found in indus-
trial and urban atmospheres are serious fac-
tors in the corrosion and failure of electrical
connectors and circuits.
  The ability of particulates to damage and
soil  buildings,  sculpture, and  other struc-
tures is particularly great in cities where
large quantities of  coal and sulfur-bearing
fuel oil are  burned.  Particles may cause de-
terioration  to many types  of masonry  by
acting as reservoirs for the harmful  acids
generated by the combustion of these fuels.
In  addition to direct erosion  and  physical
degradation of materials, particles stick to
surfaces with which they come  in contact,
forming a film of tarry soot and grit which
may or may not be  removed by  the action
of rain. The result is a dingy, soiled appear-
ance,  and  much  money and  effort  must
be spent to sandblast off the sooty layers that
accumulate.
  Particles  also may soil  the  painted sur-
faces of walls,  ceilings, and  the exteriors
of homes  and buildings, and, under certain
circumstances, may cause them  to become
stained and pitted.  Automobile finishes, for
example, have been  damaged by  particulate
matter  emitted from nearby industrial op-
erations.  Water  soluble chlorides and sul-
fates—mostly the iron, copper, calcium, and
                                                                               73

-------
zinc salts—are  commonly found in particu-
late samples  from cities  and  in rainwater
and may  cause  blistering  and  enhance the
weathering of  painted  surfaces.  Particles
may  settle on painted surfaces before the
paint  has  dried, thus  producing imperfec-
tions and reducing the ability  of the paint
to  protect the  surface.   Such  surfaces are
likely to soon require refinishing.
  The soiling of clothing, curtains, and simi-
lar textiles makes them unattractive and di-
minishes  their  use.  The extent of  soiling
is influenced  by a number of factors, includ-
ing the temperature, the  relative humidity,
and the  wind  conditions.  Small particles
may  penetrate  deep into  the fibers  of cur-
tains hanging in  open  windows.  Curtains
weakened by such exposure to atmospheric
soiling and acidity deteriorate  in a  charac-
teristic manner. The vulnerability  of  tex-
tile products  to  the acid  components  of air-
borne particles  also depends on the compo-
sition of the  material.  Cellulosic fibers, for
example,  such as  cotton,  linen,  hemp,  jute,
and man-made rayon, are particularly sensi-
tive to attack from such  substances  as sul-
furous  and  sulfuric  acids.  In  addition to
the aesthetic degradation and the nuisance
created by particulate matter, direct  costs
may  be associated with  the increased rate
of  deterioration  of textiles, the extra clean-
ing required, and the  manufacturing ex-
penses  for fabrics that are more resistant to
air pollution.


             G.   REFERENCES

 1.  Sheleikhovskii,   G. V.  "Smoke  Pollution  of
    Towns." Akademiya Kommunal'nogo Khzyaisfrva
    im. K. D. Pamfilova. Academy of Municipal Econ-
    omy im.  K. D.  Pamfilova.  IzdatePstvo  Mini-
    sterstva Kommunal'nogo  Khozyaistva  RSFSR,
    Moskva-Leningrad, 1949.  (Translated from Rus-
    sian and Published  for  the National  Science
    Foundation, Washington, D.C. by the Israel Pro-
    gram  for   Scientific  Translations,  Jerusalem,
    1961.)
 2.  Greenburg,  L.  and Jacobs, M.  B.  "Corrosion
    Aspects of  Air  Pollution." Am. Paint J., Vol. 39,
    pp. 64-78, 1955.
 3.  Vernon, W. H.  J. "The Corrosion of Metals." J.
    Roy. Soc. Arts, Vol. 97, pp. 578-610, 1949.
 4.  Vernon, W. H. J. "A Laboratory Study of the
    Atmospheric Corrosion of Metals." (Parts  2 and
        74
   3.)  Trans. Faraday Soc., Vol. 31, pp. 1668-1700.
   1935.
 5. Preston, R. St. J. and Sanyal, B. "Atmospheric
   Corrosion by Nuclei." J. Appl. Chem., Vol. 6, pp.
   28^4, 1956.
 6. Tice, E. A. "Effects of Air Pollution on the At-
   mospheric  Corrosion  Behavior of Some Metals
   and Alloys." J. Air Pollution Control Assoc., Vol.
   12, pp. 533-559, 1962.
 7. Hudson, J. D. "Present Position of the Corrosion
   Committee's  Field Tests  on Atmospheric Cor-
   rosion  (Unpainted Specimens)."  J.  Iron  Steel
   Inst., Vol. 148, pp. 161-215, 1943.
 8. Larrabee,  C.  P. and  Ellis, 0. B. "Report of a
   Subgroup of Subcommittee VII on Corrosiveness
   of Various Atmospheric Test Sites as Measured
   by Specimens of Steel and Zinc. Committee B-3,
   American  Society for Testing Materials." Am.
   Soc. Testing Mater. Proc., Vol. 59, pp.  183-201,
   1959.
 9. Copson, H. R. "Report of Subcommittee VI. Com-
   mittee B-3, American Society for Testing Mate-
   rials." In: Corrosion of Nonferrous Metals Sym-
   posium, Am.  Soc. Testing  Mater.,  Spec. Tech.
   Pub. 175, 1955.
10. "Air  Pollution  Measurements of the  National
   Air Sampling Network (Analysis of Suspended
   Particulates, 1957-1961)." U.S. Dept. of Health,
   Education, and  Welfare,  Div. of  Air Pollution,
   Washington, D.C., 1962.
11. Upham, J. B. "Atmospheric Corrosion Studies in
   Two Metropolitan Areas." J. Air Pollution Con-
   trol Assoc., Vol. 17, pp. 398-402, 1967.
12. Larrabee,  C.  P. "Effect of Composition and En-
   vironment on Corrosion of Iron and Steel." Am.
   Soc. Metals, pp. 30-50, 1956.
13. Antler,  M. and Gilbert, J. "The Effects of Air
   Pollution on Electric  Contacts." J. Air Pollution
   Control  Assoc., Vol.  13, pp.  405-415, 1963.
14. Williamson,  J.  B. P.,  Greenwood,  J.  A. and,
   Harris,  J. "The Influence of Dust Particles on
   the Contact of Solids." Proc. Roy. Soc., Ser. A
   (London), Vol. 237, pp. 560-573, 1956.
15. Carey, W. F.  "Atmospheric  Deposits  in Britain:
   A Study in Dinginess." Intern. J. Air Pollution,
   Vol. 2, pp. 1-26, 1956.
16. Meller, H. B.  and Sisson, L. B. "Effects of Smoke
   on  Building Materials."  Ind.  Eng.  Chem., Vol.
   27, pp. 1309-1312, 1935.
17. Le  Clerc,  E.  "Economic and Social  Aspects of
   Air Pollution." In: Air Pollution (World Health
   Organization), Columbia University Press, New
   York, 1961, pp. 279-291.
18. Yocom, J.  E.  "The Deterioration of Materials in
   Polluted Atmospheres." J. Air Pollution Control
   Assoc., Vol. 8, pp. 203-208, 1958.
19. Cartwright, J. Nagelschmidt, G., and Skidmore,
   J. W.  "The  Study  of  Air  Pollution with the
   Electron Miscroscope." Quart. J. Roy. Meteorol.
   Soc., Vol. 82, pp. 82-86, 1956.
                            347-335   P.O. 3   69-461   REV.  REPRO

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20.  Giles, C. H. "Adsorption. II. In Air Pollution and
    in Natural Processes." Chem. Ind.  (London), Vol.
    19, pp. 770-781, 1964.
21.  Holbrow,  G.   L.  "Atmospheric  Pollution: Its
    Measurement and Some Effects  on Paint." J. Oil
    Colour  Chemists  Assoc., Vol. 45, pp. 701-718,
    1962.
22.  Fochtman,  E. C. and  Langer,  G. "Automobile
    Paint Damaged by Airborne  Iron Particles." J.
    Air Pollution Control Assoc., Vol.  6, pp. 243-247,
    1957.
23.  Tabor, E. C. and Warren, W. V. "Distribution of
    Certain  Metals  in  the  Atmosphere of  Some
    American Cities." Arch.  Ind. Health, Vol. 17, pp.
    145-151, 1958.
24.  Waller R.  E., Brooke,  A. G. F.,  and Cartwright,
    J. "An  Electron Miscroscope  Study of Particles
    in  Town Air." Intern. J.  Air Water Pollution,
    Vol. 7, pp. 779-786, 1963.
25.  Graff-Baker, C. "The Effect of Dust Particles on
    the  Electrical  Resistance  and Anti-Corrosive
    Properties of Varnish and Paint Films." J. Appl.
    Chem., Vol. 8, pp. 500-598, 1958.
26.  Parker, A. "The Destructive Effects of Air Pol-
    lution  on Materials."  The  Sixth  Des  Voeux
    Memorial Lecture. (Presented at the Annual Con-
    ference of the National Smoke Abatement Soci-
    ety,  Bournemouth,  England,  September  28,
    1955.)
27.  Rees, W.  H.  "Atmospheric Pollution and Soiling
    of Textile Materials." Brit. J.  Appl. Phys., Vol.
    9, pp. 301-305, 1958.
28.  Petrie,  T. C. "Smoke and the Curtains." Smoke-
    less Air, Vol. 18, pp. 62-64, 1948.
29.  Tebbens,  B.  D. "Residual Pollution Products in
    the  Atmosphere." In: Air Pollution, Chapter 2,
    Vol. 1,  1st edition, A. C. Stern (ed.), Academic
    Press, New York, 1962, pp. 23-40.
                                                                                           75

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            Chapter 5
ECONOMIC EFFECTS OF ATMOSPHERIC
      PARTICULATE MATTER

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                          Table of  Contents
                                                                     Page
A. INTRODUCTION                                                   79
   1.  The Role of Economic Analysis                         .             79
   2.  Gross Estimates                                            .      80

B. EARLY ECONOMIC STUDIES                                      81
   1.  Pittsburgh                                                       81
   2.  Other Early Economic Studies                              .   .     81

C. RECENT  EFFORTS                           .               .81
   1.  Household Effects             .                    ....     81
   2.  Property Value Studies        .                                    83
   3.  Productivity Studies          	      ....     84

D. SUMMARY                                                 .84

E. REFERENCES                                       	      85


                            List of  Figures
Figure
5—1  Maintenance Frequency as a Function of Particle Concentration in
     the Upper  Ohio River Valley and the National Capital Area  (for
     Households of Above-average Income)         .        .  .      . .     82


                             List of  Tables
Table
5-1  Estimated Costs Due to Air Pollution (Mellon Institute Pittsburgh
     Study)                             .    .      .  .                  81
5-2  Differences in Cleaning Costs Incurred at Steubenville and at Union-
     town  	      	                .     82
 78

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                                       Chapter 5

      ECONOMIC EFFECTS OF ATMOSPHERIC PARTICULATE MATTER
           A.  INTRODUCTION

    1.   The Role of Economic Analysis

   It is, perhaps, misleading to cordon off the
so-called economic effects of particulate pol-
lutants from the effects which are the grist
of this document. All of the effects discussed
in this document have an economic dimen-
sion.  Some of the economic dimensions are
easier to measure than others. It is difficult
to determine,  for example, what is the value
of preserving the health, or indeed the life,
of  individuals adversely affected  by  pollu-
tion.  It is somewhat easier  to discover dif-
ferences in expenditure patterns attributable
to the presence of air pollution.
   Difficult or  easy, such valuation is a logi-
cally necessary part of the air quality stand-
ards  decision process.   Communities  desir-
ous of a  more favorable environment are
confronted with the need for two bodies of
fact.  First, there are the physical and  tech-
nological  laws that govern  the generation,
transport, and control of air pollution.  Sec-
ond,  there  are the  undesirable  effects of
pollution on man and his environment.  Fur-
thermore'  these two realities conspire to pro-
duce  a dilemma.  On  the one hand, if the
undesirable effects of  air pollution are to
be avoided, economic  resources that might
otherwise be  used  to  satisfy other worthy
community objectives  will have to be  used
for air pollution  control  instead, and the
other objectives  foregone. If, on  the other
hand, all these other objectives are retained
undiminished, the effects of  a polluted en-
vironment  must  be  endured. It  is evident
that some  sort of balance must be struck.
Precisely where this balance is achieved is
a matter  for  the individual  community to
decide.
   The tools of economic analysis can illu-
minate the nature of  this dilemma and can
even, with some qualification, indicate a way
out. It is sometimes suggested, for instance,
that the monetary value of the undesirable
consequences of not controlling air pollution
be balanced against the consequences of  in-
stituting control.  This is the thrust  of the
much-heralded cost-benefit  analysis,  under
which the  decision maker must consider the
available alternatives and choose that which
seems most  favorable.  Comparisons  are
made insofar as possible in monetary  terms,
with the dollar serving as a  common denomi-
nator. It is the purpose of this chapter to
review the as-yet-small body of literature on
the  economic  value  of  the effects  listed
throughout this volume.
   A major difficulty in assessing damages
due to particulate air pollution lies in iso-
lating the  effects of particulates from those
of other classes of air pollutants, such as sul-
fur oxides, ozone, oxides of nitrogen, and
others,  including  odors.  The present state
of the arts with respect to the measurement
transport,  ambient dosages, and the  short-
term  and  long-term  effects of the several
air pollutants in  various  concentrations,
durations,  and conditions, demands that in-
creased  attention,  including an  expanded
research effort, be given to the determina-
tion  of the effects of  air pollution  and the
economic costs of  those effects.
   It is a major objective of research into
the economic effects of air pollution to  estab-
lish quantitative relationships between vary-
ing levels  of  pollution and outcomes (the
effects of  those levels)  and ultimately  to
arrive at acceptable  measures of the eco-
nomic costs attributable  to  them.  In turn,
when  such  costs are averted they become the
benefits of air pollution control.
                                                                              79

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           2.   Gross Estimates
  A review of the physical effects cited in
previous  chapters  suggests the  possibility
of estimating damage  factors and costs of
damages.  The basic measurement procedure
involves four steps:
     1. Identification of nonoverlapping cate-
       gories  of air  pollution damage;
     2. An estimate of the total value of the
       category, regardless  of the air pol-
       lution effects;
     3. Determination  of  an  air  pollution
       damage factor incorporating assump-
       tions  or knowledge of the  relation-
       ships between the total  size of the
       category and the damages due to air
       pollution; and
     4. Application of this damage factor to
       the total value of the  category, in
       order to  estimate  the  damages due
       to air pollution and those due to the
        particular pollutant.
For example,  one category of effects is the
corrosion  of  steel structures which necessi-
tates painting.  An estimate might be devel-
oped along the following lines.  The  Steel
Structures  Painting  Council,  Pittsburgh,
Pa., estimated the annual  cost of corrosion-
inhibiting coatings  applied to steel  struc-
tures at $500 million in 1965.1*  This figure
is adjusted at an annual rate of increase of
6 percent, yielding a 1968 estimate of $590
million.2  The Council estimated that a large
proportion of the paint was applied because
of factors such as humidity and chemicals.
They suggested that particulate air pollu-
tion may  be responsible for about 5 percent
of the need for corrosion-inhibiting paints.
This factor was used to determine damages
due to air pollution and the cost of the paint,
estimated  at $29.5  million. Added to this
is the  labor required  to  apply  the  paint.
Labor is  approximately 2.5 times the cost
of the paint as shown in the 1949 study by
Uhlig3**  The  total  paint  and  labor  gives
  * Estimate supplied on March 11, 1965; contacted
again  on April 24, 1968, but no' further work had
been done.
  ** This 2.5 labor factor still holds true, as can be
seen by comparing  total recorded household repair
expenditures versus expenditures for materials in re-
cent years.  In 1963, for example, the ratio was 2.3.
a total estimate of $103 million per year as.
the cost of painting steel structures because
of air pollution.
  Commercial laundering, cleaning, and dye-
ing is another category of  loss due to dirty
air.  In  1963, commercial laundering, clean-
ing,  and  dyeing costs amounted to  $3,475
million.4  Between 1958 and 1963, these costs
were increasing by 5 percent annually. The
adjusted figure for this  category for 1968
thus becomes $4,350 million.
  The  Beaver Report found evidence sug-
gesting  that one-third of laundry  costs in
England were attributable  to the effects of
air  pollution.6  A  damage factor for this
category for the United States for the cost
of commercial laundering, cleaning, and dye-
ing due to air pollution becomes $870 million.
  Transportation delays is another good ex-
ample of an economic loss. Air  pollution  is
a  major  cause of reduced visibility. The
Civil Aeronautics  Board  reported that in
1962 low visibility resulting from  smoke,
haze, dust,  and sand in the air  possibly
caused 15 to 20 plane crashes.7 Other costs
of low visibility include travel delays, diver-
sions, cancellations, and  the  cost  of  trans-
portation  to individuals who  wish to  escape
polluted areas on weekend trips. Land trans-
portation  costs may  well  include  similar
losses. In  air travel alone, the total costs of
diversion, cancellation delays, and crashes
were estimated at $803  million  for  I960.8
Today, the cost would be higher.  If as little
as 5 to 10 percent is attributed to air pollu-
tion, $40 to $80 million or more  is involved.
  Automobile washing is another example.
Expenditures  on   automobile  washing
amounted to $143 million in 1963.9 This cate-
gory grew by almost 10 percent per year be-
tween  1958 and 1963. Extending this rate,
yields an  estimate of $210 million for car
washing in 1968.  The  $210 million is in-
creased by another 50 percent to $300 million
also, to adjust for the fact  that washing by
the  car owner is  not  included in the lower
figure.
  The   largest  proportion   of  automobile
washing is  probably  caused  by particulate
air pollution. A damage factor of 80 per-
cent is  assumed for  car washing, and ex-
penditures for  automobile  washing due to
       80

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the effects of air pollution  would be about
$240 million for 1968.
  If this procedure could be repeated  for
nonoverlapping  categories of damage due
to particulate air pollution, additional esti-
mates  of such damages could be developed.

    B.   EARLY ECONOMIC STUDIES

              1.  Pittsburgh
  One of the first comprehensive surveys of
damage  due  to  air  pollution in the United
States was conducted in Pittsburgh during
the years 1912 to 1913 by the Mellon Insti-
tute.  The estimates in the  Pittsburgh  in-
vestigation were based on  economic losses
due to dustf all and smoke and were obtained
through   interviews of   individuals.   The
items of cost  and the total cost  to the com-
munity were ascertained as  shown in Table
5-1.
  The Mellon Institute investigators  arrived
at an annual per capita cost of $20 in  1913.
Health effects were not  included; aesthetic
losses at the time were judged to be $5 per
person above the $20.10
Table 5-1.—ESTIMATED COSTS DUE TO AIR POL-
  LUTION (MELLON  INSTITUTE  PITTSBURGH
  STUDY.10

Causes  of expenditure                   Cost
To smoke maker:
  Imperfect combustion   ,      ....     $1,520,740
To individual:
  Laundry bills	1,500,000
  Dry cleaning bills  . .       .          750,000
To household:
  Exterior painting      .   .     ...    330,000
  Sheet metal work                   1,008,000
  Cleaning and renewing wall paper .      550,000
  Cleaning and renewing lace curtains      360,000
  Artificial lighting  ..      .             84,000
To wholesale and retail stores:
  Merchandise         .    .          1,650,000
  Extra precautions	     450,000
  Cleaning        .       ...            750,000
  Artificial lighting          . .          650,000
  Department stores        	     175,000
To quasi-public buildings:
  Office buildings           	      90,000
  Hotels    .               ...     22,000
  Hospitals    .      	     .  .        55,000
Total ..       	$9,944,740
    2.   Other Early Economic  Studies
   A comprehensive study of the economic
effects  of  air pollution in Great Britain is
described  in  the Beaver Report  in 1954.6
This study considered  both  direct costs and
efficiency losses.  The  direct costs  included
laundry and  domestic cleaning; the clean-
ing, painting,  and repair of buildings;  the
corrosion of metals and consequent cost of
replacement and  of   providing protective
coverings; damage to goods;  additional light-
ing; and extra hospital and medical services.
Efficiency  losses  were  represented by  the
effects  on  agriculture  of damage  to  soil,
crops,   and domestic  animals;  interference
with  transport; and   reduced  human  effi-
ciency due to illness.
   Le Clerc, writing in 1961 about economic
losses  due to  air pollution,  cited data from
France and Great Britain, as well as some
general data on  economic losses in the United
States.   The foreign  data were quoted  in
local monetary units, which have varied over
the years in relation to the value of the dol-
lar.  Even  those  figures  relating  to  the
United  States  are cited in the context  of
the value of the dollar at the time of study.
Some  of the  data  contained estimates on
medical services; others did not.11
   In these two studies no attempt was made
to relate economic losses to the ambient par-
ticle concentration.

         C.   RECENT EFFORTS
           1.  Household Effects
   More  recent  attempts  to  assess  specific
economic losses  due to  air  pollution have
been made by Michelson and Tourin in the
Upper Ohio River Valley and elsewhere.12-16
The investigators made a comparative analy-
sis of  Steubenville,  Ohio and  Uniontown,
Pennsylvania.  The socioeconomic  and  cli-
matic   data  were  generally  comparable,
whereas the air pollution levels, using par-
ticle concentration  (/*g/m3) as  an  index,
were dissimilar. Uniontown had an annual
average of 115 /ig/m3, while Steubenville had
an annual average of 235 ju.g/m3.
   Six categories of possible loss were studied
in each community:
    1.  Outside  maintenance frequencies of
       houses (cleaning painting, etc.) ;
                                                                                81

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     2. Inside  maintenance  frequencies  of
       houses  and apartments (walls, win-
       dows,   drapes,  curtains,   Venetian
       blinds,  carpets, and furniture);
     3. Laundering  and  dry  cleaning  of
       clothing  (with  distinction between
       summer   and  winter  maintenance
       practices);
     4. Maintenance  of women's  hair and
       facial care;
     5. Inside maintenance of offices  (clean-
       ing and painting); and
     6. Store   operation  and  maintenance
        (cleaning, painting, and other main-
       tenance items; losses  due to spoilage
       of merchandise).
  Data from  only the first four  categories
were used in the comparative analysis owing
to the heterogeneity  of  the establishments
interviewed and the  small number  of re-
spondents for  the  last two categories, nos.
5 and  6.  It will be  noted that these items
of cost are  related for the most part to the
effects of particulate  matter rather than to
all air pollutants.
  For  each  loss category three types of data
were sought:
     1. Activity  frequency;
     2. Incidence (i.e., the proportion of the
       population to  which various frequen-
       cies  were applicable); and
     3. Socioeconomic  characteristics  (i.e.,
       household income, educational level).
Questionnaires were designed separately for
each area of activity to collect accurate in-
formation on  frequency of maintenance op-
erations.  Although  income  data  were ob-
tained in steps  of $2000,  only two  income
categories were used in the final compara-
tive  analysis:  "less than $8000" and "over
$8000."  The  maintenance  frequency factor
was  calculated,  and  the frequency  factors
were converted  into  dollar values.
  Table 5-2 shows the  calculated  extra per
capita and  total costs incurred by Steuben-
ville as a result of air pollution.
  The Upper Ohio River study also included
a third city, Martins Ferry, Ohio,  where the
particle  concentrations  were roughly  mid-
way between those of  the first two cities.
Table 5-2.—DIFFERENCES IN CLEANING COSTS
  INCURRED AT STEUBENVILLE AND  AT UN-
  IONTOWN.12
                           Gross cost
        Activity            Differences
                  (Steubenville over Union town)
                                     Per
                       Annual      Capita*
Outside maintenance of
  houses              $ 640,000       $17
Inside   maintenance  of
  houses and apartments  1,190,000        32
Laundry and dryclean-
  ing                   900,000        25
Hair and facial care       370,000        10
Total
                      $3,100,000
                                     $84
  * Based on estimated 1959 population of 36,400.

The average  frequency of maintenance op-
erations in Martins Ferry fell almost pre-
cisely  midway between those  in  Steuben-
ville and Uniontown.
  The curve  relating costs of air pollution
and suspended particle  concentrations, the
latter  being used as an index of air pollu-
tion, was found by these investigators to be
essentially a straight line.  Using these data,
the authors extrapolated  the straight  line
of Figure 5-1 back to the average particle
concentration  of  the  rural stations  of the
National  Air  Sampling Network (NASN).
  4.5i

O 4.0 •
K  3.5
O
ss-
  3.0 •
212.5
<->S
z-e
|3l.5
ui
Z 1.0
       D BASED ON TWO PI LOT STUDIES
         (10 MAINTENANCE ITEMS EACH)
       •BASED ON TOTAL OF 23 ITEMS
        (UPPER OHIO RIVER STUDY
        DATA ONLY)
                           1 STEUBENVILLE
                           2 MARTINS FERRY
                           3 UNIONTOWN
                           4 SUITLAND
                           5 ROCKV1LLE
                           6 FAIRFAX CITY
     0   25   50  75  100 125  150  175 200 250 300
     MEAN ANNUAL SUSPENDED PARTICLES (fig / m3)

FIGURE 5-1. Maintenance Frequency as a Function
  of Particle Concentration in the Upper Ohio River
  Valley and the National Capital Area (for House-
  holds  of  Above-average  Income).  (This figure
  shows that  maintenance  frequency increases al-
  most linearly with the mean suspended particle
  concentrations.)
       82

-------
The mean annual  rural  station concentra-
tion of  suspended  particulate matter for
1959 to 1961 was 25 /x/m3.
  A similar  investigation of  comparative
costs due to air pollution was conducted by
Michelson  and Tourin in the metropolitan
Washington,  D.C.,  area in 1967.  The char-
acter   of  metropolitan Washington  differs
markedly from that of Steubenville, the lat-
ter having much  heavy industry (steel mills,
etc.).  The Washington pilot study was has 3d
on a selection of families in private dwellings
only.
  Four communities of the Washington, B.C.
area (Rockville-  Maryland; Suitland, Mary-
land;   Hyattsville,  Maryland;  and  Fairfax
City, Virginia) were originally selected for
study  because they represented extremes in
particle  concentrations for  outlying areas.
At  the time, they all had  a large proportion
of  middle-income  families.   The  returned
questionnaires were processed (according to
the replies) by income group. Since it was
expected that families in the very low and
very high income  brackets  would be  rela-
tively  insensitive to  particulate  pollution,
only  the  data   in  the  $10,000-to-$14,000
bracket were utilized.  Deficiencies in the air
quality data for Hyattsville precluded its in-
clusion in the analysis.
  Results from  the three suburban Wash-
ington communities compared quite favor-
ably with the results from the Upper  Ohio
River  Valley study on the ten items which
were common to both studies.  Figure 5-1
shows  the relationship between  suspended
particle concentrations and maintenance fre-
quency ratio  (urban/rural) for  the  two
studies combined, as well as  for the Upper
Ohio River Valley study alone.
  It may be noted  that in both sets of data
the association between the maintenance fre-
quency ratios  and suspended particulates is
taken to  be linear over the range of  the ac-
tual data, rather than an expected  leveling
out of the "curve" at extremely high con-
concentrations of particulates. Maintenance
frequency  ratios were not  translated into
costs in the suburban Washington communi-
ties because  of  widely  different socioeco-
nomic  and time differences between  the two
study areas.  The importance of the studies
lies  not so much in the estimates of cost,
which are likely to vary in place and time,
but in the estimates of differences in main-
tenance. It should be  noted that the use of
common cost/maintenance operation has the
effect of understating the true difference in
expenditures for the items studied between
the two areas.
  The Michelson-Tourin  studies have sug-
gested one approach to the problem of esti-
mating the costs  of some of the effects of
particulate air pollution.  The results of in-
vestigations to date are highly suggestive of
the existence of a significant relationship be-
tween the costs of household and personal
maintenance and the existence of air pollu-
tion.
  A word of caution  in the  interpretation
of these results is in order. It is well known
that causation and statistical correlation are
not one and the same.  There are a number
of  other factors, not investigated  in  the
studies of Michelson and Tourin, which could
be highly correlated with air pollution, and
which could  be casually  related to the fre-
quency with which the various personal hy-
giene  and  property  maintenance routine
studied are performed. For example, highly
urbanized areas are likely to have both rela-
tively high levels of air pollution and a rela-
tive abundance of the materials and skills
necessary for  the performance of hygiene
and  maintenance operations  (e.g.,  dryclean-
ing establishments, beauticians,  etc.). More
work is needed to find out  unambiguously
just what forces are operating.

        2.   Property Value Studies
  In 1967 the  results  of  investigations into
the effect of air pollution on property and
other  values  in St.  Louis,  Syracuse, and
Philadelphia  were published  in a book by
Dr. Ronald Ridker entitled Economic Costs
of Air Pollution—Studies in Measurement.17
The  studies  were somewhat  inconclusive;
they dealt generally with air pollution effects
and did not attempt to isolate the effects of
particulates.  Nevertheless, the effort repre-
sents an important methodological milestone
because it describes some important attempts
to determine the economic extent of air pol-
lution  damage  and includes some  practical
                                                                               83

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suggestions for the guidance of investiga-
tors.  For example, in the chapter on "Soil-
ing  and  Material—Damage  Studies,"  Dr.
Ridker expresses pessimism with respect  to
the  value  of additional studies based  on
analysis of currently available data and, cit-
ing  the high cost of  surveys, proposes as
an alternative "a special type of experimen-
tal approach to the gathering of the relevant
economic information."
  The recommended approach would seek  to
establish the physical  and  biological effects
of various types and combinations of air pol-
lution in varying concentrations and dura-
tions. It would include  study of the effects
of weather conditions  and attempt to estab-
lish  predictive relationships  that  could de-
scribe the amount of damage that would re-
sult  from specific exposure conditions.  The
resulting  damage functions  could then be
subjected to economic analysis in an effort
to translate effects into costs.
  Ridker's studies of air pollution and prop-
erty values  were  limited  to  cross  section
studies. They tended to  show an inverse re-
lationship between property values and air
pollution levels as measured by mean values
for sulfation rates.
  Other   investigators,   including  T.  D.
Crocker,18  have demonstrated that the dif-
ference in land value between a polluted and
a nonpolluted area is an appropriate measure
of potential gain from an abatement policy.
  The results of property-value studies ap-
pear encouraging in that they are a  step  in
the direction of defining a function relation-
ship between reductions  in air  quality and
economic loss.  They supplement the studies
of effects  of air  pollution described  previ-
ously.
         3.  Productivity  Studies
  Many  feel and some  are convinced that
air pollution, and especially the combination
of  suspended  particulates with sulfur  di-
oxide, is associated with an increasing inci-
dence of lung and respiratory ailments and
heart disease.19-20
  To the extent that  particulate air pollu-
tion affects the  respiratory tract and pro-
duces or  contributes  to illness among the
working population, it may substantially re-
duce human productivity and result in eco-
nomic  losses.  Economic losses would result
from work-loss days, reduced worker pro-
ductivity, and  a shortened  productive work
life.  At this time, it is  not possible to do
more than speculate about the possible mag-
nitude of this  possibly significant economic
loss.
  Efforts to provide  useful  economic esti-
mates of the effects of disease have long been
a major problem for economists.  Neverthe-
less, estimates have been made for a number
of diseases and agreement appears to be de-
veloping  on measurement  methods.  The
most economically useful  measure  of  the
effects of reduced productivity would be the
capitalized value or the  present  discounted
value of gross  lost production.21-22 Progress
is reported in  methods of valuing a human
life,  apart from livelihood. All efforts to con-
struct  acceptable  estimates  of the  costs of
poor health or early death attributable to air
pollution  depend on the results of research
that can establish dependable cause  and ef-
fect  relationships.

             D.   SUMMARY
  The cost of  painting steel structures be-
cause  of  air pollution,  particularly due to
particulate  matter,  has  been estimated at
about $100 million a year.  The annual cost
of commercial laundering, cleaning, and dye-
ing due to air pollution is estimated  at $850
million.  The adverse effects of air pollution
on air  travel were estimated minimally at
$40-$80 million  in  1960;  obviously,  they
would  be greater today.  Expenditures for
car washing, including washing  by the car-
owner involved, due to air pollution are esti-
mated at about $250 million in  1968.  This
assumes the principal cause of frequent car
washing  is particulate air pollution.  The
Michelson and  Tourin studies, despite their
stated deficiencies, reveal a general relation-
ship between levels of particulate air pollu-
tion and  increased  frequency of household
maintenance operations.   Unfortunately,  it
is not readily  possible to convert these re-
lationships into cost relationships  that would
be uniformly applicable to all communities.
  Studies  of  air pollution  and  residential
property values, while limited by  data avail-
ability, strongly  suggest  that a statistically
       84

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significant  inverse  relationship  may exist
between  higher  levels  of particulate  and
other air pollution and residential property
values.
   Efforts to provide useful economic infor-
mation  about  the effects of air  pollution
(particulates)  on  human health  and  pro-
ductivity  losses are incomplete because they
depend  on results  of  other research  efforts
aimed  at the establishment  of  dependable
cause and effects relationships.
   It  may be possible to  develop acceptable
gross estimates  of  air  pollution  damage
based on analysis  within a  group of  non-
overlapping  damage categories- as suggested
in the introduction to this chapter. If such
efforts  are carried out with care, they may
provide useful  guides  to policy  determina-
tion.  Considerably more attention needs to
be  given  to  the physical and biological ef-
fects of  air  pollution before  definitive  esti-
mates of the economic costs of air pollution
effects can be made.
   Such  estimates are not the final step, how-
ever. It will then be necessary to determine
the  costs averted  (or benefits)  by  a  par-
ticular mechanism or  program of air pol-
lution control,  in  relation  to  the costs  of
control.

              E.   REFERENCES
 I.  Steel  Structures  Painting  Council, Pittsburgh,
    Pa.,  Correspondence dated March  11, 1965.
 2.  "Statistical Abstract  of the  United   States:
    1967." 88th edition, U.S. Bureau of the  Census,
    Washington, B.C., 1967,  Table  1067.
 3.  Uhlig, Herbert H., "The  Cost  of  Corrosion to
    the United States." Chem. Eng. News, Vol. 27,
    pp. 2764-2767, 1949.
 4.  "Statistical Abstract of the United States, 1967."
    88th edition, U.S.  Bureau of the Census, Table
    1193.
 5.  "U.S. Census of Business: 1963, Selected Serv-
    ices." Vol.  6, U.S. Dept. of Commerce, Washing-
    ton, D.C., 1963, Table I.
 6. "Committee on Air Pollution Report, A  Report
   to the Minister  of Housing and Local  Govern-
   ment, Sir  Hugh  Beaver,  Chairman."  Her Maj-
   esty's Stationery Office, London, 1954.
 7. "The Polluted Air We Breathe."  American Fed-
   erationist,  Vol. 71(2),  pp.  6-11, 1964.
8. Fromm, Gary, "Civil Aviation  Expenditures,"
   In: Measuring Benefits of Government  Invest-
   ments, The  Brookings  Institution,  Washington,
   D.C., 1965, Table 2.
  9. "U.S. Census of Business:  1963, Selected Serv-
    ices Area Statistics," Vol. 7, U.S. Dept. of Com-
    merce, Washington, B.C., 1963, Table  1-8.
 10. O'Connor, J. J., Jr. "The Economic Cost of the
    Smoke Nuisance to Pittsburgh." University of
    Pittsburgh, Mellon  Institute of Industrial  Re-
    search and School  of  Specific Industries, Pitts-
    burgh, Pa., Smoke Investigation Bulletin 4, 1913.
 11. Le Clerc, E.  "Economic and Social Aspects of
    Air Pollution."  In: Air Pollution (World Health
    Organization), Columbia University Press, New
    York, 1961, pp. 279-291.
 12. Michelson,  I.  and  Tourin,  B.  "Comparative
    Method for Studying  Cost  of  Air Pollution."
    Public Health  Rept.  Vol.  81(6),  pp.  505-511,
    June 1966.
 13. Michelson, I. and Tourin, B., "Report on Study
    of Validity of  Extension of Economic Effects
    of Air Pollution Data  from Upper  Ohio River
    Valley to the Washington,  D.C. Area." Public
    Health Service  Contract PH 27-68-22, Novem-
    ber 8, 1967.
 14. Michelson,  I.  and Tourin,  B., "Household Cost
    of Living in Polluted Air Versus the Cost of Con-
    trolling Air Pollution in the Twin Kansas Cities
    Metropolitan Area." Public Health  Service Con-
    tract PH27-68-21.
 15. Michelson,  I.  and Tourin,  B., "Household Cost
    of Living in Polluted Air  in  the  Washington
    Metropolitan  Area."  Washington,  D.C. Metro-
    politan Area  Air Pollution Abatement Confer-
    ence, January 1968.
 16. Huey,  N.  "Economic  Benefit from Air Pollu-
    tion Control." Preprint. (Presented  at the New
    York-New Jersey Metropolitan Area Air Pollu-
    tion Abatement  Activity, February 5, 1968.)
 17. Ridker, R.  G., "Economic  Costs of Air Pollu-
    tion:   Studies in Measurement."  Frederick A.
    Praeger, New York, 1967.
 18. Crocker, T.  D., "Some Economic Aspects of Air
    Pollution  Control with  Special Reference to Polk
    County, Florida." Research Report to U.S. Pub-
    lic Health Service, Grant AP-00389.
 19. Committee  on  Pollution,   National  Research
    Council, "Waste Management and  Control."  A
    Report to the Federal  Council for  Science  and
    Technology, National Academy of  Science,  Na-
    tional Research  Council, Washington, D.C., Pub.
    1400, 1966.
 20. "Restoring  the  Quality of  Our Environment."
    Environmental Pollution Panel,  President's  Sci-
    ence  Advisory Committee,  The White House,
    November 1965.
 21. Weisbrod, B. A., "Economics of Public  Health."
    University of  Pennsylvania Press, Philadelphia,
    1961.
22. Klarman,  H. E., "Syphillis Control  Programs."
    In: Measuring the  Benefits  of Government In-
    vestments, R. Dorfman (ed.),  The Brookings
    Institution, Washington, D.C., 1965.
                                                                                        85

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              Chapter 6
EFFECTS OF ATMOSPHERIC PARTICULATE
       MATTER ON VEGETATION

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                          Table of Contents
                                                                  Page
A. INTRODUCTION           ,                     	      89

B. EFFECTS OF SPECIFIC DUST ON VEGETATION       	     89
   1. Cement-Kiln Dust                                 	       89
     a. Direct Effects                              	     89
        (1)  Nature of Dust  Deposition                 	        89
        (2)  Range of Effects        	                     .  .     91
        (3)  Dust Components Involved                .       	     92
     b. Indirect Effects                                    .     .     93
   2. Flourides                                                      93
   3. Soot                           .         .            	       94
   4. Magnesium Oxide               .       	     94
   5. Iron Oxide                                              .       94
   6. Foundry Dusts                        .   .            ...       94
   7. Sulfuric Acid Aerosols                    . .                      94

C. EFFECTS OF DUSTS ON ANIMALS BY INGESTION OF
   VEGETATION                            .         	     95

D. SUMMARY                                	     95

E. REFERENCES                                .         .          96


                           List  of Figures
Figure
6-1  Bean Plants Dusted with Cement-Kiln Particles               .       90
6-2  Cement-Kiln Dust on Fir Tree Branches                 	     91
6-3  Cement-Kiln Dust on Fir Tree Branches .                    ..91

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                                      Chapter  6

   EFFECTS OF  ATMOSPHERIC  PARTICULATE MATTER ON  VEGETATION
            A.  INTRODUCTION

   Little is known about the effects of par-
 ticulate matter on vegetation  and little re-
 search  has been done on the subject. There
 has been far more research on gaseous pol-
 lutants,  many  of which are readily recog-
 nized as serious toxicants to  a variety  of
 plants.   Published   experimental  results,
 mostly  from Germany, are confined princi-
 pally to settleable dusts  emitted from  the
 kilns  of cement plants. There  are a few re-
 ports on effects of fluoride dusts, soot' and
 particulate  matter from  certain types  of
 metal processing. Sulfuric  acid aerosols have
 also been studied in Los Angeles, where depo-
 sition  of  acid  droplets   has   injured the
 leaves of vegetation.   Most of the research
 was related to  the direct effects of dusts on
 leaves,  twigs, and flowers  as opposed to in-
 direct effects from dust accumulation in the
 soil.  Because of the dearth of  experimental
 results, the tenor of many reports is  directed
 as much to the question,  "Do  dusts in fact
 have deleterious effects on  plants ?" as to the
 question of extent of  injury. It is thus rea-
 sonable  to  anticipate some  disagreement.
 Such  information as  there is refers to spe-
 cific dusts  rather than to  the  conglomerate
 that is  usually  measured as urban or rural
 dustfall  (Chapter 1). The various  specific
 pollutant dusts and  their  injurious effects
 on vegetation are discussed in  the following
 sections.
   B.   EFFECTS OF  SPECIFIC DUSTS
            ON VEGETATION

          1.   Cement-Kiln Dust
  Cement-kiln  dust is the  dust contained in
waste gases from the kilns and is not derived
directly from processing of cement. It is ap-
parent from some reports,  however, that the
composition of wastes  from different kilns
operating at different efficiencies varies con-
siderably, and at times the effluents may con-
tain cementitious materials that more prop-
erly belong in the finished product. Another
important factor to consider is that literature
reports describing  effects  of dust deposited
on various plants in  the field relate to kiln-
stack materials, whereas experimental dusts
applied in laboratory or field studies were
taken  from various collectors in the waste-
gas system between the kiln and the stack.
Differences in results that may be due to this
factor have not been reconciled.
ft. Direct Effects
   (1)  Nature of Dust Deposition.—Most of
the reports concerning harmful effects  of
cement-kiln dust on  plants stress the fact
that crusts form on leaves, twigs, and flow-
ers.  As early  as  1909-1910  Peirce* and
Parish 2 noted in California that settled dust
in combination with mist or light rain formed
a relatively thick  crust on upper leaf surfaces
of affected  plants. The crust would not wash
off and could be removed only with force.
The central theme  about which  Czaja 3~6
builds his case for harmful effects is the crust
formation in the presence of free moisture.
He states that crust is formed because some
portion of  the settling  dust consists  of the
calcium silicates  which are typical  of the
clinker (burned  limestone) from which ce-
ment is made.  When this dust is hydrated on
the leaf surface, a gelatinous calcium silicate
hydrate is  formed, which later crystallizes
and solidifies to a hard crust. When the crust
is  removed, a replica of the leaf surface is
often found, indicating intimate contact  of
dust with the leaf. The relatively thick crust
formed from continuous  deposition is con-
fined to the upper leaf surface of deciduous
species but completely  encloses needles  of
                                                                              89

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conifers.  Prolonged dry periods during the
time dust is deposited provide no opportunity
for hydration, and  crusts  are not formed.
Dust  deposits which  are  not crusted are
readily  removed by  wind or hard  rain.
  Darley 3 applied kiln dusts of particle size
less than 1
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FIGURE 6-2. Cement-kiln Dust on Fir Tree Branches/
  (Incrustation has built up on the older twigs of a
  fir tree exposed to a cement-kiln dustfall probably
  in excess  of 1 mg/m2-day. Needles  have fallen
  prematurely.)

The net effect was a shortening of each suc-
ceeding year's flush of growth. A dead tree
had  heavy incrustations on  the branches
(Figure 6-3).
   (2)  Range of  Effects.—PeirceJ  demon-
strated that incrustations of cement-kiln dust
on  citrus  leaves  interfered  with light re-
quired for  photosynthesis and reduced starch
formation.  This  was  later  confirmed by
Czaja 5 and Bohnee in a variety  of plants.
More recently,  Steinhubel7 compared starch
reserve changes  in undusted  common holly
leaves and those dusted  with foundry dust.
He concluded that the critical factor in starch
formation  was the light absorption by the
dust layer, and that the influence on tran-
spiration or over-heating of leaf tissue was
FIGURE 6-3. Cement-kiln Dust on Fir Tree Branches.4
  (Very  heavy incrustation on a branch of a dead
  fir tree exposed to cement kiln dust (dustfall rates
  probably in excess  of 0.1 mg/cma-day).)

of minor significance.  Lecenier and Piquer
(see Czaja 5)  attributed the  reduced yields
from  dusted tomato  and bean plants to in-
terference  with light imposed by  the  dust
layer.  Darley 3 demonstrated  that dust de-
posited on bean leaves in the presence of free
moisture interfered with the  rate of carbon
dioxide exchange,  but no measurements of
starch were made.
  Czaja 5 stated that the  hydration process
of crust formation released calcium hydrox-
ide.  The hydrated crusts gave solutions of
pH 10-12.  Severe injury of naturally dusted
leaves, including killing of palisade and pa-
renchyma cells, was revealed by microscopic
examination.  The alkaline  solutions pene-
                                                                                91

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trated stomata on  the upper leaf surface,
particularly the rows of exposed stomata on
needles of conifer species, and  injured the
cells beneath.  Czaja 5 stated  that'  on broad-
leaved species with stomata only on the lower
leaf  surface, the  alkaline solutions first sa-
ponified the protective  cuticle on  the upper
surface,  permitting  migration of the  solu-
tion  through the epidermis to the palisade
and parenchyma tissues. Typical alkaline pre-
cipitation reaction  with tannins,  especially
in leaves  of rose and strawberry, was evi-
dence that calcium hydroxide penetrated the
leaf  tissue.  Bohne6 described similar  "cor-
rosion" of tissues under the crust formed on
oak leaves.
  Czaja 8 has presented good histological evi-
dence  that stomata of  conifers  may be
plugged by dust,  preventing normal gas ex-
change by the leaf  tissue. Uninhibited  ex-
change of carbon  dioxide and oxygen by leaf
tissue  is necessary for normal growth and
development.
  Bohne6 reported  a marked reduction of
growth of poplar trees located about one mile
from a cement plant after production in the
plant was more than doubled. The change in
growth rate was determined by the width of
annual rings in the wood. Darley 3 observed
a reduction of spring growth elongation on
conifers  in Germany, where  the oldest nee-
dles  were incrusted. He also noted that plants
were stunted and had few leaves in the heav-
ily dusted portions of an  alfalfa field down-
wind from a cement  plant  in California.
Plants appeared normal in another part of
the field where there was no  visible dust de-
posit. The dusted  plants were also heavily in-
fested with aphis  and it was not clear wheth-
er the poor growth  was due to  the  aphis
feeding or a direct effect of the dust.  Ento-
mologists suggested  that the primary effect
of the dust may have been to  eliminate aphid
predators, thus encouraging high aphid popu-
lations,  which in  turn  cause  poor  plant
growth because of their feeding.
  Anderson9  observed in New  York  that
cherry fruit set was reduced on the side of
the tree  nearest a cement plant. He demon-
strated that the dust on the stigma prevented
pollen germination. Schonbeck10  treated  a
field planting  of  sugar beets  biweekly with
2.5 g/m2 of dust and observed that infection
by leaf-spotting fungus, Cercospora beticola,
was significantly  greater than in nondusted
plots.  He postulated  that  the physiological
balance was altered by dust increasing sus-
ceptibility to infection.
  Pajenkamp"  reviewed  the  unpublished
work of several German investigators, some
of whom had applied  dust artificially to test
plants, and stated that he was opposed to the
view that dusts are harmful to plants. He
concluded that depositions of from 0.75 g/m2-
day to  1.5 g/m2-day (the latter amount rep-
resenting the maximum that might be found
in the  vicinity of a cement factory) had no
harmful effect on  plants.
  Raymond and Nussbaum 12 also stated that
cement dusts have little effect on wild plants.
On the other hand, Guderian 13 and Wentzel"
disagreed with Pajenkamp and stated that
the limited evidence at best presented a con-
tradictory picture and that Pajenkamp had
not  cited Czaja's  earlier work.5-8-15-16 They
also pointed out that a deposit of 1.5 g/m2-day
was not maximum, since other workers had
found  up to 2.5 g/m2-day, and  Bohne6 has
since reported weekly averages of up to 3.8
g/m2-day.
  According to Czaja,5 Ewert concluded that
cement-kiln dust did not clog the stomata and
that  the  crust might have a beneficial effect
as protection  against transpirational losses
and a defense against fungi. Czaja also noted
that the interpretation of evidence by Ewert
is open to question  because control plants
were heavily infested  with  flea beetles, while
test plants were not.
  (3)  Ditst Components Involved—Detail on
the injury to  be  expected from certain ce-
ment-kiln precipitator  dusts was  given by
Czaja.8 His work  is based on comparisons of
chemical composition  of dusts and resultant
injury to leaf  cells of a sensitive moss plant,
Mnium punctatum. A cut leaf was mounted
in water on a  microscope slide, and dust was
placed in contact  with the water at the edge
of the  cover slip.  Any effect of the resultant
solution  on leaf  cells could be observed di-
rectly. Eighteen  of the dusts tested in this
way fell into the following categories:
    1. No permanent injury to living cells,
       but some  plasmolysis from the con-
       92

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       centration effect of the solution;
     2. Slight  injury  to readily accessible
       cells, disruption of the cytoplasm, and
       displacement of chloroplasts; and
     3. Severe injury to all cells of the leaflet.
   Dusts  were further described as  follows:
 group 1, pH of 9.5-11.5, a relatively high rate
 of carbonation,  and  intermediate  amount
 (19-29 percent)  of clinker  phase (calcium
 silicates), and characterized by a high (36-
 79 percent) amount of secondary salts; group
 2, pH about 11, a high rate of carbonation, a
 lower (13-16  percent)  clinker phase  and
 characterized by  a high (81-85 percent) pro-
 portion of raw feed; group  3, pH 11-12, a
 very slow carbonation rate- and characterized
 by a high (17-49  percent) clinker phase. The
 greater injury was thus related to the larger
 amounts of clinker phase, which in  turn re-
 sulted in higher and prolonged alkalinity. But
 Czaja also pointed out that the composition
 of dusts within the three groups was  not con-
 sistent, and that, although not yet demon-
 strated, the constituents of a given dust un-
 doubtedly influence one another.
   In short-term experiments of two  to three
 days, Darley 3 dusted the primary leaves of
 bean plants with fractionated  precipitator
 dust obtained from Germany. The dust con-
 tained relatively  high amounts of potassium
 chloride, KC1. When a fine mist was applied
 to dusted leaves,  a portion of the leaf tissue
 was killed (up to  29 percent) and it was pre-
 sumed that the action  was due to  KC1.  In
 later experiments4  other  fractions  of the
 same dust containing very little KC1 caused
 an almost equivalent amount of  injury, thus
 indicating that KC1 was apparently not the
 only factor  involved. Current laboratory in-
 vestigations with  different particle-size frac-
 tions of  precipitator dusts collected around
 the United States  have demonstrated  varying
 degrees of injury to bean leaves when dew is
 formed on the leaves. There appears  to be no
 effect from dry  dusts  alone. Inasmuch  as
 these dusts  contain very little clinker phase,
it  is apparent  that some components other
than those connected directly with hydration
of calcium silicates may also be responsible
for injury.
   (4)  Indirect  Effects.—Pajenkamp " re-
 ported  on unpublished work  by Scheffer in
 Germany during two growing seasons, indi-
 cating  that even  considerable quantities of
 precipitator dust applied to the soil surface
 brought about  no harmful effects and no
 other lasting effects on growth or crop yield
 of  oats, rye  grass, red  clover, and turnips.
 The dust had a content of about 29.3 percent
 limestone  (analyzed as  lime,  CaO) and 3.1
 percent potassium oxide, K20. The maximum
 rate of  deposit was 0.15 mg/cm2-day. Discon-
 tinuous dustings were made at 0.25 mg/cm2-
 day to give an average of 0.075 mg/cm2-day.
 In  one  year, the yield of red  clover and the
 weight  of turnips  were higher in the dusted
 plots, although the yield of leaves in the latter
 crop was reduced. Acid manuring of the soil
 appeared to increase yield but  the interaction
 of dusting and manuring was not understood.
  While Scheffer et al." found no  direct in-
 jury  to plants, they indicated  that  there
 might be indirect effects through changes in
 soil reaction,  which  in  time  might impair
 yield.
  Stratmann and  van Haut1S dusted plants
 with  quantities  of dust  ranging  from 0.1
 mg/cm2-day to 4.8  mg/cm2-day; dust falling
 on the soil caused a shift in pH to the alkaline
 side, which was unfavorable to oats but fa-
 vorable to pasture grass.

              2.   Fluorides
  Particles containing flouride appear to be
 much less injurious than gaseous flourides to
 vegetation.  Pack  et  al.w  reported that 15
 percent  of gladiolus  leaf  was  killed  when
 plants were exposed four weeks to 0.79 jug/m3
 fluoride  as HF, but  no necrosis  developed
 when plants were exposed to fluoride aerosol
 averaging 1.9 /ig/m3 fluoride. Inasmuch as the
 material was  collected from  a gas stream
 which was treated with limestone and hy-
 drated lime, the aerosol was probably calcium
 fluoride. Moreover, when  the accumulated
 levels of fluoride in leaf tissues were about
 the same, whether from gas or particulate,
 injury from the latter was much less.
  McCune et  al.20  reported an increase of
 only 4 mm tipburn on gladiolus exposed to
 cryolite  (sodium aluminum fluoride  dust),
wherein the  washed  leaf  tissue from this
 treatment showed an accumulation of 29 ppm
                                                                              93

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fluoride. A 70-mm increase in tipburn would
have been expected if a similar accumulation
had occurred from exposure to  HF. Except
for the slight tipburn noted  above,  these
authors found that cryolite produced no vis-
ible effects on a variety of plants nor did it
reduce growth or yield.
  It is evident  from  the work of McCune
et al.20 that fluoride in plant tissue is accumu-
lated from cryolite treatment, but the rate of
accumulation is  much slower than would be
expected from a comparable treatment with
HF. For example, when comparing washed
leaf samples, exposure of gladiolus to HF for
three days at 1.01/tg/m3 fluoride resulted in
an accumulation of 26.4 ppm fluoride, where-
as only 34 ppm was accumulated from an ex-
posure to cryolite for 40 days  at  1.7/xg/m3
fluoride. Pack et al.w reported only one-third
as much fluoride accumulated from particu-
late matter as from gaseous forms.
  Both the investigations  cited above indi-
cate that much of the particulate matter re-
mains on  the surface of the  leaf and can be
washed off,  although that  which remains
after washing  is not necessarily internal
fluoride. Reduced phytotoxicity of particulate
fluoride is ascribed in part to the inability of
the material to penetrate the leaf tissue. In
addition,  McCune et  al.20 suggest that in-
activity of particles may be  due to their in-
ability to penetrate the leaf  in a physiologi-
cally active form.
                 3.   Soot
  Jennings 21 noted the suggestion that soot
may clog stomata and prevent normal gas ex-
change but that most investigations tend to
discount this effect. Microscopic examination
failed to show enough clogging of stomata on
leaves of shade trees (broad-leaved species)
to be significant. He further states that inter-
ference with light can be more serious but
he offers no data from critical experiments to
substantiate this theory.
  A well-illustrated report by Berge22 showed
plugged stomata on  conifers growing  near
Cologne,  Germany.  He  also   stated  that
growth was adversely affected.
  Necrotic spotting  was observed on leaves
of several  plants where soot from a nearby
smokestack had entered a greenhouse.23 The
necrosis was attributed to acidity of the soot
particles. Plants outside the greenhouse were
not damaged,  possibly because the particles
had been removed by rain before severe in-
jury could occur.

          4.  Magnesium Oxide
  The possible indirect effect on vegetation
of magnesium oxide falling on agricultural
soils  was reported by  Sievers.24  He noted
poor growth in  the vicinity of a magnesite-
processing   plant  in  Washington. Experi-
ments were designed  to grow plants in soil
collected at  various distances from the proc-
essing plant, in normal soil and in soil  to
which magnesium oxide was added. Suppres-
sion of plant growth was  demonstrated with
the high levels of magnesium. After the proc-
essing plant ceased operation, injury to crops
in the area became less pronounced, indica-
ting that the injurious effect was not a per-
manent one.
              5,   Iron  Oxide
  Berge,25 in Germany, dusted experimental
plots  with  iron oxide at the  rate of  0.15
mg/cm2-day over  one-  to ten-day intervals
through  the growing season for  six years.
The plots were planted with cereal grains or
turnips, and effects of treatment on the pri-
mary product, on straw, and on leaves were
noted. No harmful effect of the dust was de-
tected on either crop. There was a tendency
for improvement of yields of grain and tur-
nip roots, but this was not  statistically sig-
nificant.
            6.  Foundry Dusts
  Changes in starch reserves were compared
in  common holly leaves,  untreated,  and
treated with  dusts emitted from foundry
operations.6 The  critical factor was  the
amount of light absorbed by the dust layer,
and the  influence  on  transpiration or over-
heating of leaf  tissue was of minor signifi-
cance. These observations agree with some of
those reported above  on the range of effects
of cement-kiln dust on vegetation.

        7.   Sulfuric  Acid Aerosols
  These particles  too may  settle on  plants
and cause injury. They are not discussed here,
however, as the subject is covered in some
       94

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detail  in Air  Quality  Criteria  for  Sulfur
Oxides, a companion document.

C.   EFFECTS OF DUSTS ON ANIMALS BY
      INGESTION OF  VEGETATION
  Particles  which contain chemical compo-
nents detrimental to animal health may be
assimilated  through ingestion of plant ma-
terials.  The  toxic components may be  ab-
sorbed into  the plant tissues or may remain
as a surface contaminant on the plants. When
evaluating the potential harm  to  animals
from ingested vegetation, both absorbed and
deposited particles should be considered.
  Fluorosis  in animals has been  reported
from ingestion of vegetation covered with a
fluoride-containing  particulate matter.26  In-
jury occurs  when  absorbed plus deposited
fluoride on the plants reached 40 ppm to 50
ppm. Arsenic poisoning of cattle and sheep
has occurred from ingestion of arsenic-con-
taining particles  settled on vegetation.27

              D. SUMMARY
  There has been relatively little research on
the effects of particulate matter on vegeta-
tion, and most of the  experiments done to
date have dealt with specific kinds of  dusts
rather than the conglomerate mixture nor-
mally encountered in the atmosphere.
  The significance of dusts as phytotoxicants
is not  yet entirely clear but there is con-
siderable evidence that certain fractions  of
cement-kiln  dusts  adversely  affect  plants
when naturally deposited on moist  leaf sur-
faces. Dry cement-kiln dusts appear to have
little deleterious effect, but in the  presence
of moisture the dust solidifies into a hard ad-
herent crust which can damage plant tissue
and  inhibit  growth. Moderate damage has
been observed on the leaves of bean plants
dusted at the rate of about 0.47 mg/cm2-day
(400 tons/mi2-month) for two days and fol-
lowed  by exposure  to  naturally occurring
dew. Similarly, a marked  reduction in the
growth  of poplar trees one mile from a
cement plant was observed after cement pro-
duction was more than  doubled. At levels in
excess  of 0.1  mg/cm2-day  (85 tons/mi2-
month), incrustations have been observed on
the branches of fir trees, with the result that
needles  fell  prematurely,  shortening  each
succeeding year's flush of growth. Although
the mechanism by which injury occurs is not
entirely  understood, it is  possible that the
crust intercepts the light needed for photo-
synthesis and starch formation, causes alka-
line damage to tissues, and prevents normal
gas  exchange in leaf tissues. Injury due to
the direct effect of  high pH on cell constitu-
ents does occur. Plugging  of stomata and
reduced growth of  trees may occur within a
short distance of cement plants.
   It should be noted, however, that the harm-
ful effect of cement dusts on vegetation is not
fully substantiated  and has been questioned
by some workers. The controversy that sur-
rounds this subject is not surprising in view
of the limited research to date. In addition,
not all studies have been carried  out under
identical conditions or with dusts of the same
composition. Studies of the effects of cement-
kiln dusts deposited on the soil  also raise
questions.  Some investigators report  no
harmful  effects  at levels from  0.15 mg/cm2-
day to 0.75 mg/cm2-day (130 tons/mi2-month
to 640 tons/mi2-month), while others report
that concentrations from 0.1 mg/cm2-day to
4.8 mg/cm2-day (86 tons/mi2-month to 4,000
tons/mi--month) cause shifts in the soil alka-
linity which may be favorable to one crop but
harmful to another.
   Fluorides in particulate form are less dam-
aging to vegetation than gaseous fluorides.
Fluoride may be absorbed from depositions
of soluble fluoride on leaf surfaces. However,
the amount absorbed is small in relation to
that entering the plant in gaseous form. The
fluoride from  particulates  apparently  has
great difficulty penetrating the leaf tissue in
a physiologically active form.  The research
evidence  suggests that few if any effects oc-
cur on vegetation at fluoride particulate con-
centrations below about 2/*g/m3. Concentra-
tions of this magnitude can be found in the
immediate vicinity of sources of fluoride par-
ticulate pollution, but they are rarely found
in urban  atmospheres. Fluorides  absorbed
or deposited on plants may be detrimental to
animal health. Fluorosis in animals has been
reported  due to the ingestion of vegetation
covered  with  particulates  containing fluo-
rides. In a similar manner arsenic  poisoning
of cattle and  sheep has occurred from in-
                                                                              95

-------
gestion of arsenic-containing particulate that
had settled on vegetation.
  Soot may  clot stomata  and  may produce
necrotic spotting if it carries with it a soluble
toxicant,  such  as  one  with  excess  acidity.
Magnesium oxide deposits  on soils have been
shown to reduce  plant  growth, while iron
oxide deposits appear to have no harmful ef-
fects  and  may  be  beneficial.  Sulfuric acid
aerosols will  cause  leaf  spotting. The  levels
at which these materials may produce a toxic
response are not well defined.


             E.  REFERENCES

 1.  Peirce,  G. J.  "An Effect  of Cement  Dust  on
    Orange Trees." Plant World, Vol. 13, pp. 283-288,
    1910.
 2.  Parish, S.  B. "The Effects of Cement Dust on
    Citrus Trees."  Plant World, Vol. 13, pp. 288-291,
    1910.
 3.  Darley, E. F. "Studies on the Effect of Cement-
    Kiln Dust on Vegetation."  J. Air Pollution Con-
    trol Assoc.,  Vol.  16, pp.  145-150, 1966.
 4.  Darley, E. F. Unpublished data.
 5.  Czaja, A. T. "Uber das Problem der Zementstaub-
    wirkungen auf Pflanzen." Staub, Vol. 22, pp. 228-
    232, 1962.
 6.  Bohne,  H. "Schadlichkeit von Staub aus Ziment-
    werken fur  Waldbestande." Allgem. Forstz., Vol.
    18, pp. 107-111, 1963.
 7.  Steinhubel,  G. "Zmeny v skrobovych rezervach
    listov cezminy  po  umelom znecisteni pevnym po-
    praskom." Biologia, Vol. 18, pp.  23-33, 1962.
    (Abstract, in German, pp.  32-33, with the title:
    Veranderungen in  den Starkereserven der Blat-
    ter der gemeinen  Stechpalme nach einer kunst-
    lichen Verunreinigung durch Staub.)
 8.  Czaja, A. T. "Uber die Einwirkung von Stauben,
    speziell  von   Zementofenstaub  auf  Pflanzen."
    Angew. Botan., Vol. 40, pp. 106-120, 1966.
 9.  Anderson, P. J. "The Effect of Dust from  Cement
    Mills on the Setting of Fruit." Plant World,  Vol.
    17, pp. 57-68, 1914.
10.  Schonbeck,  H. "Beobachtungen zur Frage des
    Einflusses von industriellen Immissionen  auf die
    Krankbereitschaft der  Pflanze."  Berichte  der
    Landesanstalt  filr Bodennutzungsschutz   (Bo-
    chum), Vol. 1,  pp. 89-98, 1960.
11.  Pajenkamp,  H.  "Einwirkung  des Zementofen-
    staubes  auf Pflanze and Tiere."  Zement-Kalks-
    Gips, Vol. 14, pp. 88-95, 1961.
12. Raymond, V. and  Nussbaum, R. "A propos des
    poussieres  de cimenteries  et  leurs  effets  sur
    1'homme, les  plants, et les  animaux."  Pollut.
    Atmos. (Paris), Vol. 3, pp. 284-294, 1966.
13. Guderian, R. and  Pajenkamp, H.  "Einwirkung
   des Zementofenstaubes auf Pflanzen und Tiere."
   Staub, Vol. 21, pp.  518-519, 1961.
14. Wentzel, K. F. and Pajenkamp, H. "Einwirkung
   des Zementofenstaubes auf Pflanzen und Tiere."
   Zeit. fur Pflanzenkrankh, Vol. 69, p. 478, 1962.
15. Czaja, A. T. "Die Wirkung von verstaubtem Kalk
   und Zement auf Pflanzen." Qualitas Plant Mater.
   Vegetabiles, Vol. 8, pp. 184-212, 1961.
16. Czaja, A. T. "Zementstaubwirkungen auf Pflan-
   zen: Die Entstehung der Zementkrusten." Quali-
   tas Plant Mater. Vegetabiles, Vol. 8, pp. 201-238,
   1961.
17. Scheffer, F., Przemeck, E., and Wilms, W. "Un-
   tersuchungen fiber den Einfluss von Zementofen-
   Flugstaub  auf Boden and  Pflanze." Staub, Vol.
   21, pp. 251-254, 1961.
18. Stratmann, H. and van Haut, H.  "Vegetations-
   versuche mit Zementflugstaub." (Unpublished in-
   vestigations of the Kohlen-Stoff-biologischen For-
   schungsstation)  Essen, Germany, 1956.
19. Pack,  M. R., Hull, A. C., Thomas, M. D., and
   Transtrum, L. G. "Determination of Gaseous and
   Particulate Inorganic  Fluorides in the Atmos-
   phere." Am. Soc.  Testing Mater., Spec.  Tech.
   Pub. 281, 1959, pp. 27-44.
20. McCune, D. C., Hitchcock, A.  E., Jacobson, J. S.,
   and Weinstein, L. H. "Fluoride Accumulation and
   Growth of Plants  Exposed to Particulate  Cryo-
   lite in the  Atmosphere." Contrib. Boyce Thomp-
   son Inst., Vol. 23,  pp.  1-22, 1965.
21. Jennings, O. E. "Smoke Injury to Shade Trees."
   Proc.  Nat. Shade Tree Conf.,  10th, 1934, pp.
   44-48.
22. Berge,  H.  "Luftverunreinigungen  im Raume
   Koln." Allgem. Forstz., Vol. 51-52, pp. 834-838,
   1965.
23. Miller,  P.  M. and Rich,  S.  "Soot Damage  to
   Greenhouse Plants."  Plant Disease Reptr., Vol.
   51, p. 712,  1967.
24. Sievers,  F. J. "Crop Injury Resulting from Mag-
   nesium Oxide Dust."  Phytopathology, Vol. 14,
   pp. 108-113, 1924.
25. Berge,  H.  "Emissionsbedingte Eisenstaube und
   ihre Auswirkungen auf Wachstum und Ertrag
   landwirtschaftlicher    Kulturen."   Zeit.   Luft-
   vereinigung  (Dusseldorf), Vol. 2,  pp. 1-7, 1966.
26.  Shupe, J. L., Miner, M. L., Harrison,. L. E., and
   Greenwood, D. A. "Relative  Effects of Feeding
   Hay Atmospherically Contaminated by Fluoride
   Residues, Normal Hay Plus Calcium  Fluoride,
   and Normal Hay Plus Sodium Fluoride to  Dairy
    Heifers." Am. J. Vet. Res., Vol.  23, pp. 777-787,
    1962.
27.  Phillips, P. H. "The Effects of Air Pollutants on
    Farm Animals." In: Air Pollution Handbook, P.
    L. Magill, F. R. Holden, and C. Ackley  (eds.),
    McGraw-Hill, New York, 1956.
        96

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                  Chapter 7
SOCIAL AWARENESS OF PARTICULATE POLLUTION

-------
                           Table of  Contents
                                                                      Page
A. INTRODUCTION                                                     99

B. THE STUDIES                                                      99
   1. St. Louis, Missouri             .                .                    99
   2. Nashville, Tennessee                                              100
   3. Birmingham, Alabama                               ,              101
   4. Buffalo, New York                                                101

C. SUMMARY                                                         102

D. REFERENCES                                   	       102


                             List of  Figures
Figure
7-1  Proportion of Population in St. Louis Stating Air Pollution Present
     in Their Area of Residence, and Proportion of St. Louis Population
     Bothered                                                         100
7-2  The Level of Air Pollution Related to Public Opinion in Three In-
     come Groups (Nashville,  Tennessee)                                 101
7-3  Radial Distribution from the Center of Nashville of Air Pollution
     Levels,  Socioeconomic Status  and Public Concern About Air Pollu-
     tion   .                                                           101
 98

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                                      Chapter  7

             SOCIAL  AWARENESS OF  PARTICIPATE POLLUTION
           A.  INTRODUCTION
  The nuisance of air pollution is to some
extent a subjective perception, and its signifi-
cance is therefore influenced to some extent
by the way the public feels about pollution.
Nevertheless, it is acceptable practice to con-
clude that nuisance and  levels of pollution
are related if it can be demonstrated that a
nuisance response by a sample population is
positively related to average levels of actual
pollution.  The development of such evidence
is difficult because public reaction probably
reflects pollution peaks rather  than the mean
value for an extended time period. This prob-
lem has been considered by  McKee 1 in a re-
cent paper.
  Several studies have attempted to assess
the annoyance to a population of community
air pollution, but not all  have taken advan-
tage of available aerometric data to establish
the relationships between  air pollution levels
and attitudes and opinion  among' the affected
population. The chief value  of these surveys
lies in demonstrating that a significant pro-
portion of the  public is aware of, and con-
cerned about, air pollution, and is willing to
act to abate the nuisance.2-3 One of the most
obvious indications of the nuisance of air pol-
lution is citizen complaints. Generally speak-
ing,  the person who is willing to take the
time to telephone or write a complaint about
air pollution is probably seriously irritated by
it. And those who actually complain may rep-
resent only the top of the iceberg. There are
many who may be irritated who will not com-
plain because they do not believe complaining
will do any good. There are others, conspicu-
ous by their absence, who have moved away
because of the effects of air pollution on their
health, or because of the  aesthetic degrada-
tions  of their neighborhood. Unfortunately,
very little work has been done in this partic-
ular area of measuring the response of the
public to the nuisance of air pollution.
  It is important to note that application of
present control technology may result  in a
much  larger reduction in larger  particles
than  in  smaller  particles.  The  remaining
smaller particles  will not be as readily  dis-
cernible to the public, and awareness of par-
ticulate pollution may diminish.
  The effect of particulates on the total eco-
logical system and man's enjoyment of his
environment cannot as yet be fully evaluated.

            B.  THE  STUDIES
          1.  St. Louis, Missouri
  One major  investigation of the  relation-
ship between public opinion and  particulate
air pollution concentrations is that conducted
in the Greater St.  Louis  area.3- * This  area
comprises portions of St. Louis County,  Mis-
souri, and portions of Madison and St. Clair
Counties, Illinois. It includes  St. Louis, East
St.  Louis, and Granite City,  and thus most
of the population residing in the St. Louis
metropolitan area, as denned by the Bureau
of  the Census.  Persons  interviewed were
asked  whether they believed that air pollu-
tion was present and whether they regarded
it as a nuisance. The responses were related
to the pollution level measured both as sus-
pended particle concentration  and as soiling
index. (See Chapter 1 for a discussion of this
latter  measure of pollutant concentration.)
Figure 7-1  shows the  results obtained  for
both questions in terms of suspended particle
concentrations. It will be seen that the popu-
lation  becomes aware  of pollution before it
regards it as a nuisance. Where the  average
annual geometric mean of particles was  80
     3, better than 30 percent of the popula-
                                                                              99

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   100
 5  80
 EC CO
 SI1
 ^40
 o
 tr
 HI
 Q_
    20
POLLUTION PRESENT
NUISANCE
     0        50       100       150      200
            SUSPENDED PARTICLES, flg/m3-
              (ANNUAL GEOMETRIC MEAN)
FIGURE 7-1. Proportion of Population in St. Louis
  Stating Air Pollution Present in  Their Area of
  Residence, and Proportion of St. Louis Popula-
  tion Bothered. (This figure presents the results
  obtained from interviews.)

tion indicated awareness of air  pollution.
Fifty percent and 75 percent of the survey
population were aware of air pollution in the
area where the average annual levels of par-
ticulate matter were 120 /xg/m3 and 160 jug/m3
respectively.  None  of  the  population  ap-
peared  to be bothered by particle concentra-
tions below 50 /xg/m3, 10 percent of the popu-
lation was bothered at  a level of about 80
/xg/m3,  20 percent  was  bothered about 120
tig/m3,  33 percent at 160  /xg/m3, while 40
percent  regarded  a  concentration  of 200
/xg/m3 as constituting a nuisance.  The data
on the nuisance response in Figure 7-1 can
be expressed approximately in the form

               y~0.3x-14

over the range studied,  where y is the per-
centage of the population expressing dissatis-
faction, and x is the annual geometric mean
of suspended particle concentration in /xg/m3.
The equation  assumes that the  character of
the pollution is  the same for areas of both
high and low pollution.

         2.   Nashville,  Tennessee
  A study by Smith et al.5 reveals the com-
plexity of public opinion surveys. The method
used was similar to that in other surveys:
public opinion data were compared with aero-
metric data from the nearest air  sampling
station. One group of questions  in the public
opinion survey dealth specifically with nui-
sance  aspects  of air pollution, asking  re-
spondents to indicate whether the outside of
the house got too dirty, whether automobiles
got dirty too fast, and whether too much dust
collected on  porches and window  sills. An-
other  question, measuring  "bother" by  air
pollution was embedded in  a series of ques-
tions relating to health, and responses to it
should  not  be  compared directly with  re-
sponses of general concern and nuisance in
other surveys.  The proportion of affirmative
responses to the  question  concerning  too
much dust and  dirt on porch and window sills
showed a clear increase with increasing par-
ticle concentrations.  The data do not, how-
ever, permit a predictable quantitative state-
ment of this  responsibility.
  Survey results indicated  that  up to  3.8
percent of the respondents voluntarily  ex-
pressed awareness  and concern  about  air
pollution as  a  health problem;  an  extension
of the sample  population of about 2,850 to
the total population indicated that this figure
equated to  approximately  9,000  residents.
In response to a direct question, 23 percent
of the respondents—or approximately 50,000
residents, if the sample were projected to  the
total population—stated they were bothered
in some way by air pollution. In response to
direct  questions, several specific non-health
aspects of smog—soiling, decreased visibility,
odors,  and property damage—were cited as
affecting from 18 percent to 51 percent of
the respondents, or between 40,000 to 100,000
of all residents, as based on the sample popu-
lation. It  was  also  concluded that the fre-
quency of days of acute pollution had an  ad-
ditional influence on the proportion of people
who would express concern and annoyance.
  The study indicated some  relationships  be-
tween  level  of concern and socioeconomic
status.  At high levels of air pollution, con-
cern was greater among women of high socio-
economic status than among women of low
socioeconomic status, although at low levels
of air  pollution, those of low socioeconomic
status  expressed more concern than those of
high status.  There was also a relationship
between socioeconomic  status and  the  dis-
tance of residence from the center of  Nash-
ville (the  more affluent living farther away
in general).  Figures 7-2 and 7-3 together
       100

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demonstrate the  interlocking relationship;
Figure 7-2  uses  arbitrary scales for both
variables and should not be taken to indicate
the exact form of  the relationships.

         3.   Birmingham,  Alabama
  Stalker and Robison 6 compared data from
21  air sampling stations with public  re-
sponses from a sample of 7200 households.
Data  were gathered only from people living
within one  mile of  an air  sampling  station.
The investigators found that 10 percent of
the population believed a nuisance existed at
a seasonal (summer) mean suspended parti-
cle  concentration between 60 jug/m3 and 180
ju.g/m3, and more than 30 percent of the popu-
lation believed a  nuisance existed at levels
between 100 jug/m3 and 220 /xg/m3. The au-
thors use their dustfall data to demonstrate
that for  each increment  of  10  tons/mile2-
month  another 10  percent of  the affected
public would become concerned and consider
that level a general nuisance. Although the
published data indicates  that the relation-
I- w
p
< oc
  
-------
suspended particles. There was also a posi-
tive relationship  between  the frequency of
days  of acute levels of these pollutants  and
public opinion.

              C.   SUMMARY
  Public opinion survey data in several cities
indicate a positive relationship between the
concern expressed  about air pollution by a
population and the actual levels of particulate
pollution—used as an index of air pollution.
In  general, over  the ranges  studied, an in-
creasing  proportion of  the  population  ex-
presses dissatisfaction over air pollution as
concentrations of particulate matter increase.
However, while the several studies agree, for
the most part, in this qualitative relationship,
it is difficult to compare the studies quantita-
tively. Each  study used different sampling
schemes,  questionnaire schedules, and meth-
ods of interviewing. In  addition, the socio-
economic characteristics  of  the  population
sampled varied  from  city to city. The St.
Louis data has been singled out for quantita-
tive expression because  it showed the most
consistent association between air pollution
and public awareness.  However, it is in-
tended to serve only as an example.
  Over the approximate range 50 /ig/m3 to
200 /ug/m3, the expression

                y~0.3x-14
relates roughly the percentage of concerned
St.  Louis population, y, and the annual geo-
metric mean  suspended particle  concentra-
tion x (/tg/m3). Thus, 10 percent of the study
population was bothered by air pollution in
areas where the annual geometric mean value
of  suspended particulates  was  about  80.
/ig/m3. About 20 percent of the study popula-
tion was  bothered  in areas with an annual
geometric mean value of  120 ^g/m and 33
percent with  a mean of 160 ^g/m3.  The re-
sponses  are  probably  associated with  the
short term fluctuations in particulate levels
which underlie any averaging time period.
  Other  studies  show that when  dustfall
levels exceeded an  annual mean of 10 tons/
mile2-month,  at  least 10  percent of the af-
fected population expressed concern about a
nuisance situation.
  The available literature also indicates that
the extent to which a population considers air
pollution an annoyance is related to the fre-
quency of days with acute pollution as well
as to the  average level that the level of con-
cern is related to socioeconomic status, and
that the population becomes aware of pollu-
tion at particle concentrations  lower than
those at which they consider that it consti-
tutes a nuisance.
  In  the  St. Louis  study, 30 percent of the
study population were aware of  pollution in
areas where the annual geometric rnean value
of suspended particulates was 80 jug/m3,  50
percent in areas with 120 jug/m3  and 75 per-
cent in areas with 160 /jg/m3.

            D.  REFERENCES

 1.  McKee, H. C. "Why a General Standard for Par-
    ticulates?" (Presented at the  Symposium on Air
    Quality  Standards: The Technical Significance,
    156th National  Meeting, American Chemical  So-
    ciety, September 12, 1968.)
 2.  de Groot, I. and Samuels, S. W. "People and Air
    Pollution: A Study of Attitude in Buffalo, New
    York. An Interdepartment Report." New York
    State Dept.  of  Health, Air Pollution  Control
    Board,  1965.  (See  also de Groot, I., Loring, W.,
    Rihm, A., Samuels, S. and Winkelstein, W., same
    title, J. Air Pollution Control Assoc., Vol. 16, pp.
    245-247, 1966.)
 3.  "Public Awareness and Concern with Air Pollu-
    tion in the St. Louis Metropolitan Area." U.S.
    Dept. of Health, Education, and Welfare, Div. of
    Air Pollution, Washington, D. C., May 1965. (See
    also Schusky, J., same title, J. Air  Pollution Con-
    trol Assoc., Vol. 16, pp. 72-76, 1966.)
 4.  Williams, J.  D. and Bunyard, F.  L. "Interstate
    Air Pollution Study, Phase II Project Report,
    Vol. VII—Opinion  Surveys and Air Quality Sta-
    tistical   Relationships." U.S. Dept.  of  Health,
    Education, and Welfare, Div. of  Air Pollution,
    Cincinnati, Ohio, 1966.
 5.  Smith,  W. S., Schueneman, J. J.,  and Zeidberg,
    L. D. "Public Reaction to Air Pollution in Nash-
    ville, Tennessee." J. Air Pollution Control Assoc.,
    Vol. 14, pp. 418-423, 1964.
 6.  Stalker, W. W.  and Robison, C. B. "A Method
    for  Using  Air Pollution  Measurements  and
    and  Public Opinion to Establish Ambient Air
    Quality  Standards." J.  Air Pollution  Control
    Assoc.,  Vol. 17, pp. 142-144. 1967.
       102

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            Chapter 8
     ODORS ASSOCIATED WITH
ATMOSPHERIC PARTICULATE MATTER

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                         Table  of  Contents
                                                                 Page
A. INTRODUCTION                                 	    105
B. EVIDENCE FOR THE ASSOCIATION OF ODOR WITH
   PARTICLES                                               .     105
C. HYPOTHETICAL  MECHANISM  FOR  THE  ASSOCIATION OF
   ODOR WITH PARTICLES                         	    106
   1. Volatile Particles                                              106
   2. Desorption of Odorous Matter by Particles                         106
   3. Odorous Particles                  	    107
D. COMMON ODOR PROBLEMS                                     107
E. SUMMARY                                                 .    107
F. REFERENCES                                                  108

                           List of Tables
Table
8-1  Most Frequently Reported Odors                         .   .     107
      104

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                                      Chapter 8

     ODORS  ASSOCIATED  WITH  ATMOSPHERIC PARTICULATE  MATTER
           A.  INTRODUCTION
  The human olfactory sense has the ability
to detect and respond to thousands of differ-
ent materials or chemical compounds. Some
odorants can be detected in concentrations as
low as one part per billion. Modern instru-
mentation lacks both  the selectivity and the
sensitivity  possessed by the olfactory sense
for the detection of many odorants.
  Odorants in themselves may not cause or-
ganic disease; however, the discomfort and
disagreeableness that may be brought about
by obnoxious odors can cause some tempo-
rary ill effects. The effects that border upon
ill health include lowered appetite, lowered
water  consumption,  impaired  respiration,
nausea, vomiting, and insomnia.
  Particulate matter  in itself is not consid-
ered to be capable of directly stimulating the
olfactory sense. However, this should not be
interpreted to mean that all airborne particu-
late  matter,  as a pollutant  category, is in-
capable of stimulating the  odor sense nor
that particles cannot  be involved in the de-
livery  of the odorant to the receptor cells.
There  is evidence that some particles can
stimulate the sense of smell because the parti-
cle itself  is volatile or because this particle is
desorbing a volatile odorant.1 There is also
speculation 2  that some particulate matter is
capable of stimulating the sense of smell. Re-
gardless  of the mechanism of how particles
are involved  in the  stimulation of the olfac-
tory sense, the important fact is that  they
definitely appear to be involved.

B.  EVIDENCE FOR THE  ASSOCIATION
      OF ODOR  WITH PARTICLES
  The  idea  that odors are  associated with
particles  is  supported by observations  that
nitration of  particles from  an odorous air
stream can reduce the odor level. Rossano and
Ott2 showed that the removal of particulate
matter from diesel exhaust by thermal pre-
cipitation effected  a marked  reduction  in
odor intensity. The precipitation method was
selected  because  it  provides  minimal  con-
tact between  the  collected  particles  and
the gaseous components of  the  diesel ex-
haust stream. Thus, effects that could be
produced by a filter bed,  such as removal
of odorous  gases  by absorption in  the fil-
ter cake, are eliminated. The  observed odor
reduction must, therefore-  have resulted di-
rectly from  the removal of particulate mat-
ter. The particles  collected by Rossano and
Ott were aggregates of  spherical balls about
0.04ft. to 0.05ft. in diameter. Particulate matter
from diesel  exhaust collected  on glass fiber
filters by Linnell and Scott3 yielded a heavy
"diesel"  odor. Analysis of the particulate
matter showed that it contained no acrolein
or formaldehyde, although it did release N02
on being heated to 100°C.  The authors  con-
clude  that "no appreciable gas phase  con-
centration changes for acrolein or formalde-
hyde will result from particulate removal."
Other more or less casual observations on the
role of particulate matter in community odor
nuisance problems  appear occasionally in the
literature.4
  A second piece of evidence that implicates
the association of particles with odors is the
production of a mild odor, sometimes  de-
scribed  as "yeasty,"  in air that is passed
through a bed  of activated  carbon. Turk and
Bownes •• have shown that  this odor is  not
produced  by any  detectable  desorption of
gaseous matter from the  carbon, and  that
the same odor can be produced by passing
air through silica gel.6 It is possible  that
subfilterable particles are  associated  with
this phenomenon.
  Evidence for the association of particulate
                                                                             105

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matter  with outdoor  odors  has sometimes
been sought in the gross errors in odor in-
tensities preducted on the basis of gas-phase
dispersion  of an  odor source. However, the
interpretation of these experiments is  open
to doubt, and it is probable  that the effects
are a result of fortuitous fluctuations in emis-
sion. For example, Walter and Amberg 7 have
found that concentrations of hydrogen sulfide
in a kraft  paper  pulp  mill recovery furnace
can vary from  100 ppm to as much as 1,000
ppm. Such wide variations in emission may
help to  explain the discrepancy, reported by
Wohlers 8 for a kraft mill, between the odor
intensities  observed and those predicted from
odor threshold concentrations and dilutions
calculated  by  Button's  formula.9 The  likeli-
hood that errors in calculations of the atmos-
pheric dispersal of true gases are compara-
tively small is supported by experiments with
gas tracers like  sulfur hexafluoride  (SF6).
Collins  et al.w  and Turk et al.11 have shown
agreement between calculated and observed
concentrations  of a tracer gas at distances up
to about three miles from the emission point
to be within about 25 percent. It is true that
olfactory sensation is  responsive to concen-
trations that may be present for  only brief
intervals,  whereas  dispersion  calculations
refer to time averages for  intervals of about
one-half hour, and the tracer gas studies cited
used 20-minute integrated  samples. Some of
the discrepancy between results of odor meas-
urements on the  one hand, and results from
calculations or tracer gas tests on the other,
may therefore  be accounted for by the peak-
to-mean ratios  that result from the effects of
turbulence and eddies in the  air  stream.
There are no published data on the minimum
time duration required for odor detection or
odor nuisance responses. Efforts by Turk and
coworkers  to determine the ratio of "instan-
taneous" (one  second)  to  average (20 min-
ute) concentrations  of tracer  gas failed to
show significantly high values,  possibly be-
cause such occurrences are rare and escaped
the sampling grid. In any event, the peak-to-
mean ratios would have to be in the 1,000 to
10,000-fold range to explain observed discrep-
ancies, and we have no data that are based on
meteorological  factors alone  to support such
extreme values.
C.  HYPOTHETICAL MECHANISMS FOR
  THE ASSOCIATION OF  ODOR WITH
               PARTICLES
           1.   Volatile Particles
  Liquid or even solid aerosols may be suffi-
ciently volatile that their vaporization on en-
tering the nasal cavity produces enough gas-
eous material to be detected by smell. Such
aerosols may  be relatively  pure substances,
such as particles of camphor, or they may be
mixtures which release volatile components.
The retention of the odorous  properties of
volatile aerosols will, of course,  depend on the
prevailing  temperature  and on  the length
of time they are dispersed  in air. In a cold
atmosphere, the relatively greater tempera-
ture rise accompanying inhalation will accel-
erate the  production of  gaseous odorant.
  2.  Desorption of Odorous  Matter by
                 Particles
  Goetz 12 has treated the kinetics of the in-
teraction between gas molecules and the sur-
face of airborne particles.  His theoretical
considerations were directed to the question
of transfer of toxicants by particles, but are
also applicable to odors. Even if a given aero-
sol is intrinsically odorless, it could act as an
odor intensifier if: 1. the sorptive capacity of
the aerosol  particles for the odorant were
smaller than the affinity of the odorant for
the nasal  receptor  and at the  same time, 2.
the sorptive capacity of the aerosol particles
were large enough  to produce  an  accumula-
tion of odorant on the particle  surface. Such
aerosol particles would concentrate odorous
molecules on their surfaces, but the odorous
matter  would  be transferred  to  olfactory
receptors when the aerosol entered the nasal
cavity. The odorous  matter would  then  be
present at the receptor sites in concentrations
higher than in the absence of the aerosol. The
resulting  effect  would be  synergistic.  See
Chapter  10-C-3  for  a discussion of syner-
gistic effects of particles and irritants. These
synergistic effects may be analogous to par-
ticle-odorant  synergism.  If an  odorant is
more strongly adsorbed by the  aerosol parti-
cles than by the olfactory receptors, transfer
of the odorant to the receptors would be im-
peded and the particles would actually at-
tenuate the odor.
       106

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           3.   Odorous Particles
   No study has ever  rigorously defined the
 upper limit of particle size for airborne odor-
 ous matter.  Particles  up to about 8 or 10 x
 10 4 ju. in diameter are considered to be mole-
 cules  that can exist in equilibrium  with a
 solid or liquid phase from which they escape
 by  vaporization.  The vapor  pressure de-
 creases  as  the molecular weight  increases,
 and particles above about 10~3 ^ do not gener-
 ally exist in any significant concentration  in
 equilibrium  with a bulk phase;  hence we do
 not consider them to be "vapors." Nonethe-
 less,  it is possible that odorant  properties do
 not disappear when  particle  sizes  exceed
 those of vapor molecules.  Our knowledge
 about particles in the  size range of 1 to 5 X
 10~3 n (up to about the size of small viruses)
 is  relatively meager,  and  we  do  not know
 whether or not they can be odorous, nor what
 the effect of  an electrical  charge on their
 odorous properties might  be.  Larger parti-
 cles may also be intrinsically  odorous,  al-
 though their more significant role  may be  to
 contribute to odor by  absorbing and  desorb-
 ing odorous gases and vapors.

     D.  COMMON ODOR PROBLEMS
   Kerka  and  Kaiser13 surveyed  State and
 local air pollution control personnel and com-
 piled the list of most frequently reported
 odors shown in Table 8-1.
   Of the 35 listings in  Table 8-1, nine are
 either known to be or suspected to be particu-
 late-borne. These nine include gasoline- and
 diesel-engine exhaust, coffee roasting,  restau-
 rant odors, paint spraying, roofing  and street
 paving, asphalt manufacturing,  home incin-
 erators and backyard trash fires, city inciner-
 ator burning garbage, and open-dump fires.

              E.   SUMMARY
   Airborne particulate matter, as an air pol-
lutant category, is  normally not considered
as  a  source of odor  stimulation.  However,
there is evidence that some particulates hav-
ing volatile components can produce an odor
response in human receptors.
   Further, by a suggested  mechanism of ad-
sorption and subsequent desorption, an odor-
ant may be transferred by a particulate sub-
   Table 8-1.—MOST FREQUENTLY REPORTED
                   ODORS
                                     Number
   Source of odor                      reported
 Animal odors:
    Meat packing and rendering plants       12
    Fish oil odors from manufacturing
      plants                              5
    Poultry ranches and processing          4
 Odors from combustion processes:
    Gasoline and diesel engine exhaust       10
    Coke-oven and coal-gas odors (steel
      mills)                               8
    Maladjusted heating systems             3
 Odors from food processes:
    Coffee roasting                 ..      8
    Restaurant odors                 .      4
    Bakeries      .                 .      3
 Paint and related industries:
    Manufacturing of paint, lacquer, and
      varnish                       .      8
    Paint spraying                        4
    Commercial  solvents              .      3
 General chemical odors
    Hydrogen Sulflde                       7
    Sulfur Dioxide                        4
    Ammonia                              3
 General  industrial  odors
    Burning rubber from smelting and
      debonding                     . .     5
    Odors from dry-cleaning shops            5
    Fertilizer plants                       4
    Asphalt odors—roofing and street
      paving                              4
    Asphalt odors—manufacturing            3
    Plastic manufacturing                  3
 Foundry odors
    Core-oven  odors                        4
    Heat treating, oil quenching, and
      pickling                             3
    Smelting                              2
 Odors from combustible waste:
    Home incinerators and backyard
      trash fires                           4
    City incinerators burning garbage        3
    Open-dump fires                        2
 Refinery odors:
    Mercaptans                            3
    Crude oil and gasoline odors             3
    Sulfur       .                        1
 Odors from decomposition of waste:
    Putrefaction and oxidation—organic
      acidsa                               3
    Organic nitrogen compounds—decom-
      position  of protein a                  2
    Decomposition of lignite (plant cells)     1
Sewage odors:
    City sewers carrying industrial waste     3
    Sewage treatment  plants                2
  a Probably related to  meat processing plants.
                                                                                 107

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strate. When one examines the various types
of odor sources which result in public aware-
ness of an undesirable situation, a significant
number of these listings are either known to
be  or suspected to be particulate-borne. A
survey of State and local air pollution control
officials   revealed  that approximately  one-
fourth of the most frequently  reported odors
are those which are known to be, or are sus-
pected to be, associated with  particulate  air
pollution. The sources of these odorous parti-
cles are  diverse, including diesel- and gaso-
line-engine  exhaust,  coffee-roasting  opera-
tions, paint spraying, street paving, and the
burning  of trash.  Despite the absence of an
exact mechanism to explain the association
of odor  with particulates, their intimate  in-
volvement  in multiple  categories of  citizen
nuisance complaints cannot be ignored.

             F.   REFERENCES
 1. Roderick, W. R. "Current Ideas on the Chemical
    Basis  of Olfaction." J.  Chem. Educ., Vol. 43, pp.
    510-520, 1966.
 2. Rossano, A. T.  and Ott, R. R. "The Relationship
    Between Odor and Particulate Matter in Diesel
    Exhaust."  Preprint.  (Presented  at the Annual
    Meeting  of the Pacific Northwest International
    Section, Air Pollution Control Association, Port-
    land, Oregon, November 5-6, 1964.)
 3. Linnel, R. H. and Scott, W. E. "Diesel Exhaust
    Composition and Odor Studies." J. Air Pollution
    Control Assoc., Vol. 12, pp. 510-515, 1962.
 4. Quebedeaux, W. A. "New Applications for Indus-
   trial Odor Control." Air Repair, Vol. 4, pp. 141-
   142, 170-171, 1954.
 5. Turk, A. and Bownes, K. "Inadequate  Stimula-
   tion of Olfaction." Science, Vol.  114, pp. 234-236,
   1951.
 6. Turk, A.,  Kakis, F., and  Morrow, J. "The Ad-
   sorbent Odor." Preprint. (Presented at the Amer-
   ican  Chemical Society meeting,  New York,  Sept.
   1960.)
 7. Walther, J.  E. and Amberg,  H. R. "Continuous
   Monitoring of  Kraft Mill Stack  Gases with a
   Process Gas Chromatograph."  Tappi,  Vol.  50,
   pp. 19-23, 1967.
 8. Wohlers, H.  C. "Odor Intensity  and Odor Travel
   from Industrial Sources." Intern. J. Air Water
   Pollution, Vol. 7, pp. 71-78, 1963.
 9. Sutton, O. G. "The  Theoretical Distribution of
   Airborne  Pollution  from  Factory  Chimneys."
   Quart. J. Roy. Meteorol. Soc., Vol. 73,  pp. 426-
   436, 1947.
10. Collins, G. F., Barlett, F. E., Turk, A., Edmonds,
   S. M. and Mark, H.  "A Preliminary Evaluation
   of Gas Air  Tracers." J.  Air Pollution Control
   Assoc., Vol. 15, pp. 109-112, 1965.
11. Turk, A., Edmonds, S. M., Mark H. L., and Col-
   lins,  G. F. "Sulfur  Hexafluoride  as a Gas-Air
   Tracer." Environ. Sci. Technol., Vol. 2, pp. 44-
   48, 1968.
12. Goetz,  A. "On  the  Nature  of the  Synergistic
   Action of Aerosols." Intern. J. Air Water Pollu-
   tion, Vol. 4, pp. 168-184, 1961.
13. Kerka, W. F. and Kaiser, E.  R. "An Evaluation
   of Environmental Odors." J.  Air  Pollution Con-
   trol Assoc., Vol. 7, pp. 297-301,  1958.
        108

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                   Chapter 9
THE RESPIRATORY SYSTEM: DEPOSITION, RETENTION,
    AND CLEARANCE OF PARTICULATE MATTER

-------
                          Table of Contents
                                                                    Page
A. INTRODUCTION                    	    Ill
B. ANATOMY  OF THE HUMAN RESPIRATORY TRACT              111
C. FACTORS AFFECTING THE DEPOSITION AND RETENTION OF
   PARTICULATE MATTER IN THE RESPIRATORY SYSTEM        112
   1. Physical-Mathematical Treatments                            .    112
      a. Deposition Mechanisms     .                                   112
      b. Aerodynamic Factors                                         113
      c. The Models                              .        ..       .114
   2. Experimental  Studies  of Factors Affecting Deposition and
      Retention                                   .                    116
      a. Total Deposition in the Respiratory Tract    .          .      ..117
        (1) Effect of Particle Size                        	    117
        (2) Physiological Parameters              .              ...    117
      b. Regional Deposition                                      .    118
        (1) Nasal Fractionation                                      118
        (2) Lung Deposition                               .           118
        (3) Comparative Human and Animal Retention      .    .        119
   3. Conclusions Reached about Alveolar Deposition              .  .  .    119
D. FACTORS AFFECTING THE CLEARANCE OF  PARTICULATE
   MATTER FROM THE RESPIRATORY SYSTEM          .    .      119
   1. Clearance  Model                          .          	     120
   2. Clearance  from the Tracheobronchial System           .      ..    121
   3. Clearance  from the Alveolar Surface               	    122
E. SUMMARY                                                       123
F. REFERENCES                                                   123

                            List of Figures
Figure
9-1  The Major Anatomical Features of the Human Respiratory System      112
9-2  The Terminal Bronchial and Alveolar Structure of the Human Lung     112
9-3  Calculated  Fraction of  Particles Deposited in the Respiratory Tract
     as a Function of Particle Radius                          .    .     114
9-4  Fraction of Particles Deposited in the Three Respiratory Tract Com-
     partments  as a Function of Particle Diameter    .              .115
9-5  Data from Figure 9-4 for the Nasopharyngeal Compartment Plotted
     as a Log-probability Function (Minute Volume: 20 1/min)         .    116
9-6  Data from Figure 9-4 for the Pulmonary Compartment Plotted as a
     Log-probability Function  (Minute Volume: 20 1/min)        .   . .    116
9-7  Schematic  Portrayal of Dust Deposition  Sites and Clearance Proc-
     esses                                 .    .  .        ....    120

                            List of Tables
Table
9-1  Respiratory Airflow Patterns for a Group of Healthy Young Men  .    113

 110

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                                     Chapter  9

        THE RESPIRATORY SYSTEM: DEPOSITION,  RETENTION, AND
                    CLEARANCE  OF  PARTICULATE MATTER
           A.  INTRODUCTION

   In urban communities, exposure to atmos-
pheric  pollutants  may constitute a health
hazard that is the most serious single conse-
quence  of air pollution. Chapters 10 and 11
discuss  the effects of  particulate pollutants
on health in terms of toxicological and epide-
miological  studies. Pollutants are likely to
enter the human body mainly via the respira-
tory system; other routes of entry are of
minor importance. Damage to the respiratory
organs may follow directly,  or the pollutant
may be transported by some mechanism to a
remote susceptible organ. It  is apparent that
a study of  the effect on health of particulate
atmospheric  pollutants requires  an under-
standing of the mechanisms and  efficiencies
of deposition of particles in the respiratory
system, and of the subsequent retention with-
in, and clearance  from- the  system, as well
as its secondary relocation to other sites in
the body. This chapter provides a brief intro-
duction to the physics  and physiology of de-
position, retention, and clearance  in the res-
piratory system. More  complete descriptions
may be found in several reviews.1-3
  Experimental studies of the several fac-
tors involved  in  deposition, retention, and
clearance processes have been backed up  by
theoretical  treatments and, in the discussion
which follows, descriptions of these theoreti-
cal models precede those of  experimental
work. One  of the latest theoretical models is
that developed  by  the Task  Group on Lung
Dynamics for Committee II  of  the Interna-
tional Radiological Protection  Commission.4
The Task Group's report establishes the use-
fulness  of the Stokes  (mass median) diam-
eter (cf. Chapter  1-A) of  a particle  as a
measure of deposition probability. This  is of
 practical importance, since the Stokes diam-
 eter may readily be determined under field
 conditions.
   The anatomy of the  respiratory system
 plays an important part in determining the
 effects of inhaled particles, and a very short
 description of this anatomy is provided. Sev-
 eral extensive presentations of morphological
 studies are available,5-6 and Davies 7 gives a
 formalized concept of the anatomy of the
 human respiratory tract.
     B.  ANATOMY OF THE HUMAN
         RESPIRATORY TRACT
   The respiratory system is usefully broken
 down into three main sections:
     1. the nasopharyngeal structure;
     2. the tracheobronchial system; and
     3. the pulmonary  structure, within
       which oxygen and carbon dioxide are
       exchanged between respired air and
       blood.
   Figure 9-1 shows the location of these fea-
 tures. The nasal passages lead, via  the naso-
 pharyngeal structure and the larnyx, to the
 trachea and the bronchi, which are made up
 of 23 generations of dichotomous branching
 tubes terminating in the alveolar (air) sacs.
 Figure 9-2 is  a schematic representation in
 greater detail of the terminal bronchiole and
 pulmonary structure.
   Estimates  of numbers of alveoli  differ
 somewhat from one experimenter to another:
 a recent suggestion 8 is that there are 300 mil-
 lion, together with 14 million alveolar ducts.
 The alveoli are probably between 150/t and
 400/i in diameter, so that the total alveolar
 surface varies between about 30 m2 and 80
m2. The increasing total cross-sectional area
with progression down the respiratory tract
                                                                           111

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                                  NASAL
                                 CAVITY

                                 ORAL
                                CAVITY
                                  TERMINAL
                                BRONCHIOLES
                                     LEFT
                                   BRONCHUS
          RIGHT  LUNG
                          LEFT LUNG
FIGURE 9-1. The Major Anatomical Features of the
  Human Respiratory System.  (The diagram shows
  the major divisions of the human respiratory tract
  into nasopharyngeal,  tracheobronchial,  and  pul-
  monary compartments.)

leads to a marked decrease in the velocity of
air movement with depth.
  The nasopharyngeal and tracheobronchial
structures possess ciliated epithelium covered
with mucus  arising from goblet cells  and
secretory glands. These structures also make
up the anatomical "dead space," since oxygen
exchange between the blood and air does not
occur here. If the volume of  this dead space
is Vd, the lungs must draw in a volume V in
order to  obtain a volume V-Vd of fresh  air,
which is  called the tidal volume. The surface
of the pulmonary structure consists of non-
ciliated moist epithelium that, although de-
void of  the secretory  element found in  the
tracheobronchial  tree,  is covered  by a sur-
face-active material, without which alveoli
would totally collapse (atelectasis) at the end
of respiration.
     C.   FACTORS  AFFECTING  THE
   DEPOSITION AND  RETENTION OF
    PARTICULATE  MATTER IN THE
        RESPIRATORY SYSTEM
   1.  Physical-Mathematical  Treatments
  The   theoretical   physical-mathematical
   TERMINAL
  BRONCHIOLE
                              RESPIRATORY
                              BRONCHIOLE
                                                                                 ALVEOLI
FIGURE 9-2.  The Terminal Bronchial and Alveolar
  Structure  of the Human Lung.  (The diagram
  shows the pulmonary structure of the respiratory
  tract.)

treatments use information on the anatomical
structure and airflow rates in the respiratory
tract, together with knowledge of the physi-
cal factors influencing the deposition of par-
ticles. The  deposition  mechanisms  will  be
considered first; aerodynamic factors  con-
nected with airflow and gas mixing in the
respiratory system will then be mentioned
before proceeding to a discussion of the three
main models which have been developed.
a. Deposition Mechanisms
   Three mechanism are of importance in the
deposition of particulate matter in the respi-
ratory tract—inertial impaction, gravitation-
al settling  (sedimentation), and  diffusion
(Brownian motion). The relative significance
of these deposition mechanisms  varies  with
anatomical and physiological  factors,  with
the nature of the airflow, and with the char-
acteristics  of the  aerosol such  as  particle
shape and density.
   Particles in an ni"«t~eam  impinge onto a
       112

-------
 surface when the inertia  of  the  particle is
 great enough to overcome the resistive forces
 of the medium  and  intercept the surface of
 the obstacle. If gravity is neglected, the path
 of the particle is determined by the air veloci-
 ty, the  mass and air  resistance of the par-
 ticle, and size and shape of the obstacle.  In-
 ertial impaction is therefore of greatest im-
 portance in the deposition of large particles
 of high density, and at points in the respira-
 tory  system  where  the direction of flow
 changes at branching points in the airways.
   The size of the particle as well as its densi-
 ty are singificant factors in determining the
 importance of deposition by gravitational set-
 tling. The terminal velocities (settling veloci-
 ties)  of spheres of  unit density  in  air for
 10-ju,, l-/x, and 0.1-,u particles are 2.9 xlQ-1
 cm/sec, 3.5 XlO-3 cm/sec, and 8.6X10-5 cm/
 sec respectively. Density also plays  a part
 since the sedmimentation behavior of a 0.5-
 n  particle of  density  10  g/cm3  would  be
 equivalent to that of  a unit density particle of
 1.5-fi diameter.  Hence, gravitational settling
 is most important in the depositon of large
 particles or of high-density particles such as
 dusts of heavy metals.  Irregularly  shaped
 particles will have an aerodynamic size  less
 than the size  predicted  on the basis of the
 measured geometric  diameter.
  The third main mechanism active in bring-
 ing about deposition of particles in the res-
 piratory tract is Brownian movement or  dif-
 fusion; it is the result of bombardment of the,
 particles by air molecules which are in rapid,
 random, thermal motion. Diffusion is negli-
 gible  for  large particles  (say above 0.5-^,
 diameter), while it may be the major mecha-
 nism  for  the  deposition of  small particles
 (below  Q.lp.) in the  lower pulmonary tract,
 where airflow rates  are lower  and the dis-
 tances to  the  walls  are less.
 b.  Aerodynamic Factors
  Two  aerodynamic factors,  namely,  flow
 rates  and gas  mixing, are incorporated in
 the models of  the respiratory system.
  During  the  respiratory  cycle, the actual
airflow rate varies from zero up to a maxi-
mum value and then  back down to zero. Usu-
ally the expiratory phase is longer than  the
inspiratory phase and there may  be  pauses
 between the two phases. A study of the res-
 piratory airflow patterns of healthy young
 men at rest and under a wide range of work
 loads was made by Silverman et al.9 The max-
 imum inspiratory flow rate increased from a
 mean value of 40 1/min in sedentary subjects
 to 100 1/min at an exercise level of 622 kg-
 m/min and to 286 1/min at an exercise level
 of 1660 kg-m/min. The corresponding values
 for maximum expiratory flow rates were 32,
 107, and 322 1/min. The collected results are
 shown in Table 9-1.
   Changes in flow rate resulting  from physi-
 cal activity have a profound effect on particle
 deposition  in the respiratory system;  this ef-
 fect in turn  depends upon  the aerodynamic
 size of the particulate material inhaled. It has
 been demonstrated  by  Amdur,   Silverman,
 and Drinker 10 that the inhalation of irritant
 particulate material,  such  as  sulfuric  acid
 mist, can decrease the maximum inspiratory
 and expiratory flow rate in human subjects.
 Such alterations produced  by irritant par-

 Table 9-1.—RESPIRATORY AIRFLOW PATTERNS
  FOR  A GROUP OF HEALTHY YOUNG MEN.8
 Exercise      Inspiratory flow   Expiratory flow
  level      rate 1/min (max) rate 1/min (max)
 Sedentary
 622 kg-m/min
 1660 kg-m/min
 40
100
286
 32
107
322
tides could also affect deposition patterns of
particulate matter  in general, and may re-
present the physiological defense response of
the body.
  Another factor to be considered in the dep-
osition of particulate matter  in  the lung is
the role of mixing of intrapulmonary  gas
flow.  A study of this factor has been made
by  Altshuler and co-workers " using 0.4-/*
particles suspended in air.  From the meas-
ured wash-in and wash-out rates (after re-
turn to particle-free  air), the authors were
able to calculate the volume of new air which
mixed with  the residual  air. Their  data
showed that at a tidal volume of  500 ml, not
more than 11 percent to 27 percent of new air
in each successive breath actually mixed with
the residual air. It follows that nondiffusible
                                                                             113

-------
particles (above 0.5 //.) will tend to penetrate
only to the depth of the new air, while smaller
particles will have great enough diffusion
velocities to  move independently into  the
static air in the lung, in the same way that
gas molecules do.
c.   The Models
  For the present purposes,  the most impor-
tant model is that of the Task Group on Lung*
Dynamics.4  However,  two  earlier  studies,
those of Findeisen 12 and Landahl,13 are of
significance, since they were both considered
as a basis  for the Task Group model. The
Task Group finally selected Findeisen's ana-
tomical  model,  since it  appeared that the
rather   more  sophisticated  treatment  of
Landahl gave no better estimates  of deposi-
tion values.  Further, the cumulative volume
down to the end of the terminal bronchioles
in the Findeisen model is more in  keeping
with the anatomical dead space as determined
by physiological measurements.
   Findeisen12 predicted the percentage of
deposition and the site of deposition of par-
ticles of various sizes in the respiratory tract.
He estimated there would be a critical  parti-
cle size  of about  0.3-/x to 0.4-/i  radius for
which a minimal amount of 34 percent would
be deposited. This deposition  would  occur
predominantly in the terminal airways and
alveoli, thus suggesting that particles of this
size should not be dismissed as toxicologically
unimportant. Findeisen  also estimated that
the percentage deposition of  O.S-/i radius par-
ticles would be 68 percent as much as that of
l-fi  radius particles. His calculated deposi-
tions are shown in Figure 9-3. Experimental
work on deposition of particles smaller than
l-/x diameter have  borne out Findeisen's pre-
dictions.
   Findeisen's concepts of the anatomy of the
pulmonary  tract  have  been  criticized by
Weibel.14 Findeisen assumed equal and con-
stant flow  rates for inspiration and expira-
tion, a situation which does not prevail dur-
ing the respiratory cycle. Furthermore, this
simple respiratory pattern does not take into
account the unique distribution of air in the
lungs, or the factors of intrapulmonary mix-
ing of tidal and residual air in the lungs.
   Landahl13 made a similar theoretical study
 i.o-

 0.9-

Q0.8
LU
bo.7
en
 0.2

 0.1

   (X,
DEPOSITIOIM IN RESPIRATORY/
        SYSTEM
                 DEPOSITION IN ALVEOLAR
                     REGION ONLY
   10-
     ,-2
                10-
                        10°
                                         10'
                   RADIUS, JU
FIGURE 9-3.  Calculated Fraction of Particles De-
  posited  in  the Respiratory  Tract as a Function
  of Particle Radius.12  (The  figure represents the
  calculated efficiencies of deposition of particles of
  various sizes, in the tracheobronchial and alveolar
  regions of  the respiratory system, and shows the
  size for minimum efficiency.)

of  the problem of particle deposition in the
respiratory tract, but included the mouth and
pharynx  in his anatomical  model.  He em-
ployed several  tidal volumes and breathing
frequencies in his calculations, but in all cases
assumed a constant flow for both the inspira-
tory and expiratory phases. The calculations
yielded deposition values for both phases' and
took into account the  progressively smaller
fraction  of each tidal  volume which pene-
trated to the various depths. Deposition in
various regions for spheres of unit density in
the size  range 20 ^ to 0.2 ^ was predicted to
fall to a minimum at the size where the pre-
dominant force bringing about deposition is
shifting from gravitational  settling to dif-
fusion. An increase was  found in retention
 with larger tidal volumes.
   Landahl15 also made a separate considera-
 tion of deposition in the nasal passages. Ear-
 lier studies did not take into account impac-
 tion of particles on nasal hairs, or deposition
 by inertial forces as the airflow changes di-
 rection,  or sedimentation within the nasal
 chamber. Assuming a flow rate of 18 1/min,
 about 75 percent of W-/JL particles would be
 retained in the nose.  Corresponding values
 would be about 50 percent for 5-/*  particles
        114

-------
and 10 percent  for  l-/i particles.  Landahl
calculated that at flow rates greater than 18
1/min, essentially 100 percent of the particles
above 10 /*. would be retained in the  nose and
that there also would be substantial retention
of 2-/x to 5-/i particles. Nasal deposition  is
negligible for particles below 1 ^ in diameter.
It follows that the estimated pulmonary dep-
osition values of Findeisen would have to be
revised downward for the large  particles.
   The Task  Group on Lung Dynamics used
the conventional division of the  respiratory
tract into three  compartments,  and made
three fundamental assumptions in the de-
velopment of their model. These were:
     1. The log-normal  (Chapter 1-B)  fre-
       quency distribution  is generally ap-
       plicable to particle sizes in the atmos-
       phere. It should be noted that this as-
       sumption is by no means universally
       accepted.
     2. The physical activity of the individual
       affects deposition primarily by its ac-
       tion on ventilation, since physiological
       adjustment to the  demands of in-
       creased minute  ventilation is  to in-
       crease tidal volume more than respi-
       ratory frequency. In terms of produc-
       ing the greatest change in deposition
       throughout the respiratory tract, the
       effect of an increase in volume at a
       constant respiratory frequency was
       considered.  (A   frequency  of  15
       breaths per minute was used together
       with  tidal volumes of 750, 1450, and
       2150  cm3  (BTPS);  the lowest tidal
       volume is  considered  representative
       of a mild-to-moderate activity state.)
    3. The aerodynamic properties of the
       particle,  the  physiology  of  respira-
       tion, and the anatomy of the respira-
       tory tract provide a basis for a mean-
       ingful and reliable deposition model.
  The Task Group's aim was to amalgamate
size-deposition  relationships  into a  general-
ized form which would directly  permit the
prophetic use of  dust-sampling information.
By conventional sampling methods, the count
median  diameter or the mass median diam-
eter is obtainable along with the geometric
standard  deviation, 
-------
 to characterize the deposition probabilities of
 the  entire particle  size distribution  from
 which it emerged.  Other parametric  func-
 tions of the particle  distribution failed  to
 produce such  simple  cohesive relationships.
   The effect of the varying tidal volumes is
 shown in the original report (Figure 12, Ref-
 erence 4), but it is possible, for practical pur-
 poses, to use  a mean  curve for 1450 ml  to
 represent all three respiration states.  This
 implies  that the minute volume will control
 the total amount of particulate material de-
 posited  but will  not  ordinarily have  much
 effect on the percentage deposition.
   The final step was to plot the combination
 of mean distribution  versus  mean respira-
 tory  performance curves on  log-probability
 paper, a manipulation suggested by the sig-
 moid shape of the nasopharyngeal and pul-
 monary  deposition  curves.  The results are
 shown in Figure 9-5  and Figure 9-6.  The
 deposition in the tracheobronchial compart-
 ment is considered,  for practical purposes,
as  constant at approximately 8 percent of
the inspired particulate matter.
  The results of the Task Force's calcula-
tions suggest the type  of atmospheric sam-
pling data  that will be most meaningful in
the correlation of atmospheric particle  con-
centrations and human health.  In particular,
the insensitivity of the model to aerodynamic
size distribution leads the Task Force to  pro-
pose  the concept of "respirable"  dust sam-
ples, in which the samplers are designed and
calibrated to provide data from which one
can determine the mass median diameter in
aerodynamic terms.   Such   considerations
have a special significance in  connection with
particles, such as asbestos, which possess an
abnormal deposition behavior.

   2.   Experimental  Studies of Factors
     Affecting Deposition and Retention
  Experimental studies of the deposition of
inhaled particulate  material  may be divided
into two broad categories.  The first  group
  101
<£
til
UI
5
  10°
ui
  10"
  1 fl-
                                      I
                                                  102
                10   30 50  70
                  DEPOSITION, %
                               90
                                      99  99.9
FIGURE 9-5.  Data  from Figure 9-4 for the Naso-
  pharyngeal Compartment Plotted as a Log-proba-
  bility  Function.   (Minute  volume:  20  1/min).
  (The figure shows that there is a roughly linear
  relationship between deposition efficiency and the
  logarithm of the particle size.)
IT
111
UJ
ea
z

5
111
5
                                                  101
                                                  10°
                                                  10-
                                                                             I	I
                10   30  50  70   90

                  DEPOSITION^
                                                                                     99 99.9
FIGURE 9-6. Data from Figure 9-4 for the Pulmo-
  nary Compartment Plotted as  a Log-probability
  Function (Minute Volume: 20 1/min).  (This fig-
  ure shows that there is a roughly inverse linear
  relationship between deposition  efficiency and the
  logarithm of particle size.)
       116

-------
deals with the measurement of total deposi-
tion in the respiratory tract, and the second
group is concerned with regional deposition
within the various areas of the respiratory
tract.
a. Total Deposition in the Respiratory Tract
  Experimental studies  of deposition  were
first  made by Lehmann  et  al.,16  Saito,17
Owens,18 Baumberger,19  and Sayers et al.w
Drinker et al.,21 measured respiratory deposi-
tion in  man with  simultaneous recording of
respiratory frequency and minute volume.
The concentration of particulate matter was
measured  in  the  chamber, from which air
was inhaled, and in the exhaled air. An  aver-
age  retention value of 55 percent at a fre-
quency  of  six to 18 respirations per minute
was found.
   (1) Effect  of Particle  Size.—The first sys-
tematic study of the influence of particle size
on the percentage deposition of inhaled dust
was made  in 1940 by Van Wijk  and Patter-
son.22  The subjects- at  rest, inspired  min-
eral dust particles from the air of South Af-
rican gold  mines.  Percentage deposition ap-
proached 100  percent above 5 //, and had de-
creased to  about 25  percent at 0.25 /i, to the
limit of the measuring technique.
  Brown 23> 24  made  a series of tests on hu-
man subjects in which he found that the per-
centage deposition is directly  proportional
to the particle size and to the density of the
suspended  material.  (Size refers here to the
physical dimensions  of  aggregates of par-
ticles rather than to unitary particles.)
  More sophisticated experiments by  Alt-
shuler et al.23 have used a homogeneous  aero-
sol  of  triphenyl  phosphate,  with particle
sizes  in the range 0.14  i*.  to 3.2 /x to study
deposition  in  human subjects.  It was found
that  deposition was dependent  on particle
size and that  the minimum deposition diam-
eter was 0.4 yu., which is in reasonable accord
with  the prediction made by Findeisen (0.6
/x to 0.8 ju) 20 years earlier.
  The deposition of  coal  dust in human sub-
jects  has been shown 26 to  rise from a mini-
mum efficiency of about  30 percent at  0.5 p
to almost 60 percent at 0.1 /* (mass median
diameter).  Such  an overall efficiency sug-
gests that  the absolute efficiency of  deposi-
tion  of  the particles smaller than 0.1 /i in
the pulmonary air spaces is close to 100 per-
cent.  Direct measurement of the particulate
matter concentration in samples of alveolar
air showed an efficiency of removal of essen-
tially 100 percent down to about 0.5 /x and
better than 80 percent  for particles well be-
low 0.1 ^.2T
  A hygroscopic particle  may  collect suffi-
cient  water to increase its size significantly
over that in the dry state. Dautrebande and
Walkenhorst26 have therefore compared the
deposition  of sodium chloride with that of
coal dust. Using the dry size of the salt par-
ticles, deposition curves different from those
for coal dust were obtained, but on correcting
(by a factor of seven) to account for the
growth  of salt to liquid droplets in the res-
piratory tract, the curves were quite similar
for the  two particles.  This result is of con-
siderable practical  significance, as it  means
that hygroscopic particulate air  pollutants
will be   deposited  to a higher  degree than
mineral  particles of an  equal size.  The Task
Force Report4  gives equations which may
be applied to correct for the effect of hygro-
scopicity on deposition.
  (2) Physiological parameters.—In Brown's
experiments,23'24 the  effect of varying res-
piratory frequency, tidal volume, and minute
volume was determined by making measure-
ments on subjects  breathing at rest, under
various work loads on  a bicycle ergometer,
and breathing air containing added C02. The
conclusions of this work were:
    1. Percentage  deposition   is   inversely
       proportional to  respiratory  rate for
       rates below 20  per minute and  an
       increase in  frequency above 30 per
       minute  causes no further  change in
       percentage deposition;
    2. Percentage  deposition   is   inversely
       proportional  to  the minute volume;
       and
    3. Percentage  deposition is  unaffected
       by  tidal volume,  vital  capacity,  or
       relative humidity of the  inspired air.
  The results are essentially in agreement
with the predictions of Findeisen and Lan-
dahl (although no effect of tidal volume  on
deposition was observed).
  In general agreement with Brown's result
                                                                              117

-------
for respiratory rate, Altshuler et al.25 found
in  their  experiments that  slower,  deeper
breathing  gave  greater  deposition  than
faster, shallow breathing. It is also shown
that,  in agreement with prediction, the dif-
ferences due  to  respiratory  frequency are
greater for 1.6-/* particles than for  0.14-/*
particles.  For the 1.6-/* particles,  impaction
and settling  are  the dominant mechanisms
of deposition,  and the number settling varies
as the first power of time. With  the 0.14-/*
particles,  Brownian  motion is the dominant
deposition  mechanism, and the number set-
tling  varies as the square root of time.
  Experiments with stearic acid particles 28
have  revealed an interesting phenomenon of
minimal deposition at normal breathing fre-
quencies of 15 to 20 breaths per minute and
an increase when the frequencies were either
higher or lower than this.  A range of res-
piratory rates from less than 5 per minute
to more than  35 per minute  was  used, and
particle diameters lay between 1 /* and 5 /*.
On the other hand, Morrow and Gibb 2Q find
that the deposition of 0.04-/X sodium chloride
particles in dogs and  human subjects de-
creases  with  an  increase in  breathing fre-
quency. The  deposition percentages  them-
selves (66.5 percent in dogs, 63.4 percent in
man)  are  close to those  predicted  by Fin-
deisen. An increase in tidal volume increased
the deposition in these experiments in dis-
tinction to the absence of a tidal volume ef-
fect found by  Brown.
  There appears to  be a  direct relationship
between percentage  deposition and holding
time  in the lungs for particles of 0.55 /* di-
ameter.30
b. Regional Deposition
  The experimental  study of  regional depo-
sition of particles is more complex than is
the determination of overall total deposition
in the respiratory tract.  Various specialized
techniques such as the inhalation  of  radio-
active particles followed by external count-
ing over specified portions of the  chest, or
radioautography of the lungs, have been em-
ployed.  The  technique  of fractionating ex-
haled  air and  counting the particles in each
fraction has also been used.
   (1) Nasal  Fractionation.  — Lehmann,31
using a test  dust of unspecified size, found
a median nasal deposition of 46 percent in
185 normal subjects and 27 percent in  241
silicotics. Dust-laden air was blown through
the nose and out through a tube in the mouth.
Tourangeau and Drinker 32 found deposition
efficiencies of 10 percent to 25 percent with
airflow  rates  through the nose of 4 to 12
liters per minute.  Their dust was calcium
carbonate of a size comparable to the silica
particles found  in  silicotic  lungs.  Reversal
of the  direction of flow did not alter  the
values.
  The most extensive experimental studies
of nasal penetration have been made by Lan-
dahl's group.33-34 The  results, especially for
corn oil particles, confirm theoretical predic-
tions,15 and nasal deposition is found experi-
mentally to have a strong dependence on  air-
flow rate.
   (2)  Lung   Deposition.—Wilson  and  La
Mer35 used an aerosol  of glycerol containing
Na24Cl as a tracer in seven normal subjects
who breathed through the mouth at varying
frequencies. Particle sizes were in the range
of 0.2 p. to 2.5 fi. External  chest counts en-
abled estimates  of lung burden to be made,
and the pulmonary deposition curve showed
a maximum of about 80 percent for particles
of about 1.6-ju, diameter.  A  second peak at
0.4 n was interpreted in terms of the differ-
ing optimum sizes for deposition in the finest
airways and in the pulmonary air spaces;
deposition in  these two areas  was not  dis-
tinguished by the method employed.
  Indirect estimates  of upper respiratory,
alveolar, and total deposition in human sub-
jects were made by Brown et al'.,3S using a
technique for fractionating the exhaled  air.
In each successive portion,  the C02 content
was measured together  with  the  particle
count and thus the amount of lung air in
each  portion  of the  sample could be  esti-
mated.  Equal removal  efficiencies in both
directions were assumed, and a series of ex-
pressions was developed for calculating total,
alveolar, and  upper respiratory  deposition.
The median particle size of the  china clay
test dust  ranged from 0.24 /* to  above 5 /*,
and the total retention decreased systemati-
cally from 90 percent  or more for  particles
5 /j. and greater, down to 25 percent to 30
       118

-------
percent for  0.25-/* particles.  Tracheobron-
chial retention also decreased systematically
with particle size but reached zero at a finite
size above 1 p.  Alveolar retention, calculated
as the percentage of the number of particles
reaching the  alveoli, remained  between  90
percent and 100 percent for all sizes down to
about  1 fi; below that, it decreased in pro-
portion to total retention.  The  calculated
curve for alveolar deposition showed an opti-
mum size at 1 /*.
   (3)  Comparative Human and Animal Re-
tention.—A technique essentially  similar to
that used by Brown  in his experiments  on
human subjects  (see  Section  C-2-a-(2)
above) has been employed by Palm, McNer-
ney, and Hatch 37 for studies on guinea pigs
and monkeys.   This provides  a valuable
chance to compare results of experiments  on
laboratory animals and man.  The test dusts
included china  clay,  carbon,  antimony tri-
oxide,  and  bacillus subtilis var. niger.  The
overall pattern of the results was similar in
the experimental animals and in man.  The
actual deposition and retention values were
very close for the monkey and for man. For
the guinea pig, total  retention was close to
100  percent for 3-/t  particles and fell sys-
tematically with decreasing particle size.  In
comparison  with man,  the total retention
was higher, especially in the lower size range.
Alveolar retention was essentially the same
in both species, and  it is the tracheobron-
chial retention  which  i^ higher in the guinea
pig than in man. Although alveolar deposi-
tion in the guinea pig was much lower for
1.5-/J. particles  than in man, because of the
removal of these  particles in the tracheo-
bronchial tract, the optimum size for alveolar
deposition was similar in both species.

 3.  Conclusions Reached about  Alveolar
                Deposition
  Three  important  conclusions   may  be
reached about  the effect of particle size on
alveolar deposition:
    1. There  is a maximum efficiency  of
       deposition at a size between about 1 /*
       and 2 p.;
    2. There is minimum  efficiency for a
       size of around 0.5 /*; and
     3. The percentage of particle deposition
       for sizes  less than  0.1 p.  is just as
       great as for sizes more than 1 p (Fig-
       ure 9-3).  This last conclusion is not
       always  given enough weight,  even
       though  its prediction by Findeisen 12
       has  been adequately  confirmed ex-
       perimentally.26- 29
  On the other hand, the importance of the
second conclusion above should not be over-
emphasized, as it refers only to the proba-
bility of  deposition.  If their number,  and
therefore the mass deposited, is relatively
great (as may well be  for aged aerosols),
then particles  in the 0.1-/J,  to 0.5-ju size re-
gion may be as  important as smaller  and
larger particles in provoking toxic response.
This is also important when considering par-
ticles containing absorbed material.

     D.   FACTORS AFFECTING  THE
     CLEARANCE  OF PARTICULATE
  MATTER FROM THE RESPIRATORY
                 SYSTEM
  A well-known  response of a living orga-
nism to foreign matter  is its attempt to rid
itself of, or in  some way inactivate, the un-
wanted  material.  The  overall effectiveness
of clearance mechanisms in the lung is well
illustrated by  the  finding  that  the actual
amount of mineral dust found in the lungs
of miners or city dwellers at autopsy is only
a minor fraction  of the total dust that must
have been deposited there during their lives.
The clearance  of certain particles may be
very slow. The rate is dependent upon size,
site of deposition, and chemical constitution.
  Relative to other factors, the importance
of removal from the respiratory  system of
trapped particulate materials depends on the
rate at  which  the  material elicits a  patho-
logical or physiological  response. The effect
of an irritant  substance which produces  a
rapid response may depend  more on  the
amount of initial trapping than on the rate
of clearance. On the other  hand, materials
such as carcinogens, which may produce  a
harmful effect only after long periods of ex-
posure, may exhibit activity only if the rela-
tive  rates  of clearance  and deposition  are
such that a sufficient concentration of mate-
rial remains in the body long enough to cause
                                                                             119

-------
                     (a)
                                     NASOPHARYNGEAL
                                       COMPARTMENT
          BLOOD
TRACHEOBRONCHIAL
  COMPARTMENT
                                           T
                             (b)
                                                            Id)
 TT
lf)J  *(g)
                                        PULMONARY
                                       COMPARTMENT
 GASTRO-
INTESTINAL
  TRACT
FIGURE 9-7. Schematic Portrayal of Dust Deposition Sites and Clearance  Processes.  (This diagram  illus-
  trates  the various deposition sites and clearance  mechanisms used  in the  model of the lung developed
  by the Task Group on Lung Dynamics, and described in the text.)
pathological  change.  In such  a  case,  the
amount of initial deposition will be of rela-
tively minor importance.
  Different clearance mechanisms operate in
the different portions of the respiratory tract,
so that the rate of clearance of a particle
will depend  not only  on its physical and
chemical properties such as shape and size,
but also on the site of initial deposition. Fur-
thermore, the presence  of a nonparticulate
irritant or the coexistence of a disease state
in the lungs may interfere with the efficiency
of  clearance mechanisms and  thus prolong
the residence time of particulate material in
a given area of  the respiratory tract. Kotin
and Falk 38 have emphasized the possible im-
portance  of this interaction in the  patho-
genesis of lung  cancer (Chapter 10).

            1.   Clearance Model
   The Task Group on Lung Dynamics * con-
sidered the respiratory clearance of particu-
          late matter, as well as its deposition, and the
          model they developed provides a convenient
          starting point for a discussion of experimen-
          tal work on clearance.
            Figure 9-7 presents a schematic diagram
          of all deposition sites  and clearance proc-
          esses. The three conventional compartments
          of the respiratory tract discussed in connec-
          tion with the deposition model are used here.
          DI is the particulate  material inhaled;  D2
          is the material in the exhaled air; D3, D4, and
          D5 are the particles deposited in the naso-
          pharyngeal, tracheabronchial, and pulmonary
          compartments respectively, expressed as per-
          centages  of  Dj and determinable from the
          deposition model. In addition to the respira-
          tory tract,  three  other compartments  are
          listed:  The  gastrointestinal tract,  systemic
          blood, and the lymph.  The  different absorp-
          tion  and translocation  processes which are
          associated with the clearance of various com-
          partments are as follows:
       120

-------
     a. Rapid uptake  of  material  deposited
       in the nasopharynx directly into the
       bloodstream.
     b. Rapid clearance  of all  particulate
       matter from the nasopharynx by cil-
       iary transport  of mucus.  This route,
       and d, have clearance half-times of
       minutes.
     c. Rapid absorption  of  particles de-
       posited in the  tracheobronchial com-
       partment into  the systemic circula-
       tion.
     d. The  rapid  ciliary clearance of the
       tracheobronchial compartment.  Par-
       ticles cleared by this route go quan-
       titatively to the gastrointestinal tract.
     e. The direct  translocation  of  material
       from  the  pulmonary  region to the
       blood.
     f. The realtively  rapid clearance phase
       of the pulmonary  region dependent
       on recruitable  macrophages. This in
       turn  is coupled to  the  ciliary mucus
       transport process for which a  half-
       time of 24 hours has been suggested.
     g. A second pulmonary clearance proc-
       ess, much slower than f,  but still de-
       pendent upon endocytosis and ciliary
       mucus transport.  This  process  is
       rate-limited in  the  pulmonary region
       by the nature of the particles per se.
     h. The slow removal  of particles from
       the pulmonary compartment via the
       lymphatic system.
     i. A secondary pathway in  which par-
       ticles cleared by pathway  h are intro-
       duced into the systemic blood.
     j. The  collective  absorption of cleared
       material   from  the gastrointestinal
       tract  into the  blood. No attempt is
       made to include this factor in the de-
       velopment of the model.
  The use of the model requires a knowledge
of values for two parameters for  each of the
pathways just  described.  These   are the
amount of material residing in the  compart-
ment which  follows a particular exit  path
(regional  fraction), and the rate at which
that fraction of the material is cleared (bio-
logical half-time).  In some cases the kinetic
values are physiologically controlled and are
more or less independent of the nature of
the  particulate  material. In other cases the
physiochemical nature of the deposited mate-
rial  is the critical factor.
   A classification  of inorganic compounds is
given in the Task Force Group Report, which
contains the  best available information  on"
both deposition  and  clearance  of inhaled
particles.
   The Task  Force Group  stressed the need
for  research  in the  area  of solubilities of
various compounds in water, in very dilute
alkali, and in the presence of proteins. Some
of the work  done by Morrow et al.39  corre-
lates clearance  of material from the lungs
with other properties such as ultrafilterabil-
ity and clearance from intramuscular injec-
tion sites. These data will be of value in
understanding the effect of physiochemical
properties on clearance.
   It will be  seen that the clearance mecha-
nisms can be divided broadly into those de-
pending on ciliary action and those  which
operate in the virtually nonciliated  pulmo-
nary region.   The  two sections which follow
describe experimental work concerned with
these two general subdivisions.

 2.  Clearance from  the Tracheobronchial
                  System

   A blanket  of mucus in the tracheobron-
chial region   is kept  in  continual upward
movement by the  ciliary activity of the col-
umnar epithelium lining which extends down
as far as the  terminal bronchioles. The fre-
quency of the ciliary beat has been found 40-41
to be 1,300 per minute in the rat, while the
overlying  mucous  fluid was found to move
at an average rate of 13.5  mm per minute.
Similar transport  rates of 15 mm per min-
ute in excised trachea, and  18 mm per min-
ute in intact  animals, have been reported by
Antweiler.42 In this latter study, several par-
ticulate materials were used, including soot,
coal  dust,  lycopodium spores, cork dust, alu-
minum powder,  and glass and lead spheres.
Transport rates seemed to be unaffected by
size-  weight, or shape of the particles except
in the case of the glass spheres, which were
said  to  be sufficiently smooth to  allow the
                                                                             121

-------
mucus to flow over them rather than to trans-
port them.
  It has been demonstrated 43-44 that in the
human  lung the mucus  flows over  only 10
percent to  20  percent of the theoretically
available  surface  at  the dividing  passages
where  the  airways  branch. The  mucous
blanket divides  and flows in two directions
around the margins  of  the opening.   This
phenomenon, taken together with the greater
probability  of impact deposition at bifurca-
tions, may explain  why histological sections
show accumulations of particles at bronchial
branch points.45
  In studies of respiratory system clearance,
use has been made of mono-disperse aerosols
tagged with radioactive substances to per-
mit the subsequent fate of the material to
be followed  by external counting techniques.
In general,  the  results indicate that  clear-
ance occurs in two distinct phases  of  about
two and ten hours duration, probably repre-
senting the  clearance of particles from the
proximal  and distal parts of the bronchial
tree.  Albert et  al,46 studied  clearance from
the human  lung of 3-/x  and 5-/*  iron  oxide
particles tagged with 51Cr and 198Au. The
rapid phase of clearance was completed with-
in one  day, and in  most cases  within  12
hours.  The clearance  curves obtained  in
these  studies did  not differ substantially
from  those  obtained  earlier by Albert and
Arnett" who used  a heterogeneous iron ox-
ide aerosol, suggesting that.the  actual dis-
tribution  function of particle sizes may  be
of little importance in determining clearance
rates.  However- Holma48 generated a "bi-
disperse"  aerosol of 6-//, and  3-/x polystyrene
particles,  tagged respectively with 19sAu and
46Sc, and  measured simultaneous clearance
of the two sizes in  rabbits.  The larger par-
ticles cleared more rapidly than the smaller
ones.  The mean  half-life for the initial  phase
was 0.48 hours for the Q-/J. particles and 1.07
hours for the S-/* particles.  The respective
half-lives  for the long clearance phase were
69.7 hours and 210 hours.
  The effect of irritant gases on clearance of
particles is  obviously of significance where
air pollution involves this  combination  of
factors.
  Dalhamn's40-41 studies showed that  the
acute response to irritant gases such as am-
monia, formaldehyde, or sulfur dioxide was
a cessation of ciliary beat. The time to ces-
sation was  dose-related.  Chronic exposure
of rats to one of the irritants (sulfur dioxide)
slowed down or caused a complete cessation
of the transport of tracheal  mucus, but the
average beat frequency of the cilia was the
same as in  normal animals.  The cessation
of clearance was a result of an increase in the
thickness  of  the mucous layer of from  5 //.
to 25 /x.
  The material carried  upward  by ciliary
action is swallowed and thus enters the gas-
trointestinal  tract.  Brieger  and  LaBelle49
exposed animals to a water-insoluble dye and
demonstrated that 24 hours after the termi-
nation of exposure,  over  50  percent of  the
total  dye  found in the body was in the in-
testinal tract. This phase could persist for
several days, during which time a significant
intestinal  burden was present. The concen-
tration of dye finally fell to very low values
after a week or so, and most of the dye that
remained  in the body was found in the lung,
indicating that  the  rapid phase of ciliary
clearance  was finished.   It  has  also  been
shown 50 that uranium dioxide, cleared from
the respiratory system to the gastrointestinal
tract by ciliary action, is responsible for the
high urinary uranium levels seen during the
first days  after exposure to uranium dioxide
dust. The possibility of consequences of rela-
tively high concentrations of  an atmospheric
pollutant appearing  in organs remote  from
the lungs must  not  be  overlooked. In this
connection, the  high incidence of  stomach
cancer in areas suffering  from high levels
of atmospheric pollution takes on a particu-
larly ominous appearance.

 3.  Clearance from  the  Alveolar Surface
  Particles  deposited on  the  alveolar  sur-
face may  be  removed by any of the mecha-
nisms (e) to  (i)  given in the clearance model
of Section D-l, and  they  may also become
sequestered by a tissue reaction  within  the
lung  (pneumoconiosis),  or become bound to
protein  material in  the lungs. Of the sev-
eral clearance mechanisms, the most rapid is
that  involving  recruitable   macrophages
(phagocytic cells contained on the alveolar
       122

-------
surface epithelium). Phagocytosis may also
serve to render the particles incapable of in-
juring or irritating the alveolar surface epi-
thelium and may to some extent prevent the
penetration of the particles into the inter--
stitium of the lung.  The origin and behavior
of  these  alveolar  macrophages  have been
the  subjects  of  active  research in  recent
years.45- 51~53
  LaBelle M-5S  demonstrated that the clear-
ance of particulate matter by phagocytosis
can  be markedly influenced by the dust load
presented to the lung. The initial observa-
tion was made that clearance curves obtained
with microgram quantities  of  activated  ura-
nium dioxide were noticeably different from
those  obtained  earlier   using  milligram
amounts.  When carbon particles were added
to the activated uranium  dioxide to bring
the  total  weight of administered  dust  into
the range of the earlier studies, the clearance
curves were quite similar.  In seeking the
reason  for this  finding.   LaBelle  demon-
strated  that the number of free phagocytes
washed out of the lungs was  related to the
dust load  and that the amount of dust elimi-
nated from the lungs during the early post-
exposure period was proportional to the num-
ber of free phagocytic cells present.  Within
the limits of experimental error, the kinetics
of elimination  of particles  and the kinetics
of the disappearance of the phagocytic cells
following  exposure  were identical for both
inhalation and intratracheal exposures.
  The relationship between concentrations in
the different respiratory regions  during al-
veolar clearance  has been the subject of a
short-term study  by Gross,   Pfitzer,  and
Hatch.58  The clearance of four kinds  of dust
burdens   (antimony trioxide,  ferric  oxide,
quartz,  and coesite) was  followed in  rats
whose lungs  had been loaded  using  the in-
halation  and  intratracheal  injection tech-
niques.  Initially, although  the greater con-
centration of  dust was to  be  found  in the
proximal  alveoli, dust  deposition  was  also
prominent in alveoli distal to alveolar ducts.
However,  within 3 or 4 days, the dust in the
distally  situated  alveoli  had  largely  disap-
peared and had apparently become concen-
trated in the proximal alveoli.  This stagna-
tion  of dust in the evaginating alveoli of the
respiratory bronchioles and  alveolar  ducts
may help to explain the greater vulnerability
of these regions to inhaled irritants.

              E.   SUMMARY
  The respiratory system may be  divided
into  three sections—nasopharyngeal,  tra-
cheobronchial, and pulmonary systems. Dep-
osition and clearance mechanisms may differ'
for the various parts of the respiratory tract.
A particle of any size which passes the naso-
pharyngeal region may be deposited in the
remainder of the respiratory tract and, al-
though  the actual  mechanism of deposition
is primarily dependent upon the particle size,
the shape of the particle can also affect the
efficiency of its deposition. Consequently,  if
atmospheric  dust  loads  are  to be  related
quantitatively to  health  hazards,  the dust
samplers  used for monitoring should have
collection characteristics similar or the same
as the human lung. The fast phases of the
lung  clearance mechanisms are different  in
ciliated and nonciliated regions. In  cil ated
regions, a flow of mucus transports the par-
ticles to the entrance of the gastrointestinal
tract, while in the nonciliated pulmonary re-
gion phagocytosis by macrophages can trans-
fer particles to the ciliated region.  The rate
of clearance is an important factor in de-
termining toxic  responses,  especially  for
slow-acting toxicants  such as  carcinogens.
In addition, since the clearance of particles
from the  respiratory  system primarily leads
to their entrance  into the gastrointestinal
system, organs remote from  the deposition
site may be affected.  The models developed
by the Task Group on Lung Dynamics are
used in this chapter as a basis for discussion
of experimental data on  the  deposition, re-
tention, and clearance of particles.   These
models  provide  a  useful  representation of
the deposition and clearance mechanisms and
have been shown to yield  predictions which
have often been substantiated by experimen-
tal findings.
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                                                                              123

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    cal Factors Controlling the Fate of Inhaled Sub-
    stances.   II.  Retention."  Health  Physics, Vol.
    2, pp.  379-386, 1960.
52. Casarett, L. J. and Milley, P. S. "Alveolar Re-
    activity   Following  Inhalation of   Particles."
    Health Physics, Vol. 10, pp.  1003-1011, 1964.
53. Policard,  A.,   Collet,  A., and  Pregermain,  S.
    "Structures alveolaires normales  du pneumon
    examines au microscope electronique." Semaine.
    Hop. (Paris), Vol. 33, p. 385, 1957.
54. LaBelle,   C. W.  and  Brieger,  H.  "Synergistic
    Effects of Aerosols. II. Effects  on Rate of Clear-
    ance from the Lung."  Arch. Ind. Health, Vol. 20,
    pp. 100-105, 1959.
55. LaBelle,   C. W.  "Patterns  and Mechanisms  in
    the  Elimination  of Dust from the Lung."  In:
    Inhaled  Particles and Vapours, Vol. 1,  C.  N.
    Davies (ed.),  Pergamon Press, London, 1961, pp.
    356-368.
56. Gross, P., Pfitzer, E. A., and Hatch, T. F. "Al-
    veolar Clearance: Its Relation to Lesions  of the
    Respiratory  Bronchiole."  Am.  Rev.  Respirat.
    Diseases, Vol. 94, pp. 10-19, 1966.
                                                                                           125

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           Chapter 10
    TOXICOLOGICAL STUDIES OF
ATMOSPHERIC PARTICULATE MATTER

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                           Table of  Contents
                                                                     Page
A. INTRODUCTION                                              .129

B. MECHANISMS OF TOXICOLOGICAL ACTION OF PARTICULATE
   MATTER                                     	    129
   1.  Intrinsic Toxicity                                     	    129
   2.  Absorbed Substances                               .  .        .    130
   3.  Reduction of the Toxicity of Irritant Gases        .        .          130
C. TOXICOLOGICAL STUDIES OF SPECIFIC PARTICULATE
   MATERIALS                                                      131
   1.  Pathological Studies of Smoke and Carbon Particles                 131
   2.  Physiological Studies of Response to Particulate Material      .      132
   3.  Experimental Studies of Mixtures of Irritant Gases and Particulate
      Material .    .                                                   134

D. CARCINOGENESIS                                      	    137
   1.  Carcinogens                  .                                   137
   2.  Polynuclear Aromatic  Hydrocarbons as Carcinogens in Polluted
      Atmospheres                                                    138
   3.  Pathology of Carcinogenesis   	                         .         141
E. SUMMARY                    .       	     141

F. REFERENCES                           .     .         ....       142


                              List of Tables
Table
10—1  Effect of Exposure of Rabbits to  2 ppm Ozonized Gasoline on Re-
      tention of Inhaled Soot                      .                .    134
10-2  Benzo (a) pyrene Concentrations in Several Urban and Nonurban
      Areas         ...                  .                         138
10-3  Benzo (a) pyrene as a Fraction of the Total Aromatic Hydrocarbon
      Content of Several Urban Atmospheres                        .    138
10-4  Effect of Various Conditions  of Exposure on the Destruction  of
      Some Polynuclear Aromatic Hydrocarbons                          139
10-5  Percentage Recovery of Polynuclear Aromatic Hydrocarbons from
      0.5m Soot Particles and from Plasma after  Incubation with Plasma
      for Varying Periods                         .                    140
10-6  Distribution of Lung Cancer by Site of Origin   .                    141
      128

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                                      Chapter  10

    TOXICOLOGICAL  STUDIES OF  ATMOSPHERIC  PARTICIPATE MATTER
           A.  INTRODUCTION

   Experimental  toxicology,  using  specific
 atmospheric pollutants,  would  be the best
 means for deriving air quality criteria, pro-
 vided that man could be used as the experi-
 mental  animal. However, the ethical  impos-
 sibility  of  performing  experiments  using
 human  exposures  to varying concentrations
 of a wide range of compounds  precludes so
 direct  an   approach.  Although  a  limited
 amount of  intentional human  experimenta-
 tion may be possible,  most of the data for
 human  toxocology are derived  from  acci-
 dental or occupational  exposures. The use of
 laboratory animals in toxicological experi-
 ments is more straightforward, but the ob-
 vious anatomical  and  metabolic differences
 between the animals and man require the ex-
 ercise of considerable caution in applying the
 results of animal exposures to human health
 criteria. Furthermore, many of the animal
 experiments performed have left something
 to be desired in terms of air pollution toxicol-
 ogy, since the "end-point" of the experiments
 has frequently been the death of the animals
 at exposures to concentrations far in excess
 of those likely to be found, or tolerated, in the
 atmosphere. There is a  great need for chronic
 inhalation studies  to define long-term  effects
 occurring over a lifespan.
  The difficulties and  limitations  of toxico-
 logical studies  discussed in  the last  para-
 graph should not obscure the fact that an in-
 creasing amount of data useful for air quality
 criteria  is being amassed; it is, however, al-
 ways essential to bear in mind the limitations
 of the data.  Toxicological studies have shown
 that atmospheric particles may elicit a path-
 ological  or  physiological response in at least
 three ways. First, the particle  may  be in-
trinsically toxic; second,  the presence of an
 "inert" particle in the respiratory tract may
 interfere  with the clearance of other air-
 borne toxic materials; and third, the particle
 may act as a carrier of toxic material. There
 is also evidence that the presence of particles
 may occasionally  reduce the toxicity of a
 second  pollutant;  this phenomenon  is  de-
 scribed briefly. From an air pollution stand-
 point, one of the most ubiquitous particulate
 pollutants is smoke; some pathological stud-
 ies involving this  material  are presented.
 Studies of physiological response to irritant
 particles and to mixtures of particulate mat-
 ter with irritant gases are described.
   A final section of this chapter then deals
 with  carcinogenesis  and atmospheric pol-
 lutants.

 B.  MECHANISMS OF  TOXICOLOGICAL
   ACTION OF PARTICULATE MATTER

           1.   Intrinsic Toxicity
   Few common atmospheric particulate pol-
 lutants  appear to  be intrinsically toxic; of
 these, the most important  toxic aerosol  is
 sulfur  trioxide  (S03)  (either as  the  free
 oxide, or hydra ted  as sulfuric acid—H2SO4),
 which has a high degree of toxicity, at least
 for the guinea pig. Although silica (from fly
 ash) is frequently present as a pollutant, at-
 mospheric concentrations are normally too
 low to lead to silicosis. In recent years, how-
 ever, concern has been expressed over a num-
ber of  less common toxic particulate pollut-
 ants, including lead, beryllium, and asbestos.
Increasing amounts of lead (as oxides and
salts) are being discharged into the atmos-
phere as a result of the burning of gasoline
containing lead additives; on the other hand,
other sources contributing  to  atmospheric
lead seem to be decreasing and, according to
Stokinger and  Coffin,1 toxic effects due to
                                                                             129

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lead do not seem to present a serious risk to
the population at large. Beryllium (as the
oxide BeO)  can  lead to chronic pulmonary
disease with a high fatality rate. Accidental
exposures have  shown that there may be a
considerable  latency  period before disease
develops, and some alarm has been generated
over the use of beryllium as a rocket fuel,
although the rocket effluent is predominantly
a "high-fired," relatively inert form of beryl-
lium oxide. The situation with regard to as-
bestos is also potentially  serious.  Brief in-
dustrial or accidental exposures to asbestos
can lead, after a latency period of 40 years
or more, to the development of diffuse meso-
theliomas of the pleura or peritonium,  and it
is  possible that sufficient  levels of asbestos
might be generally present  in the atmosphere
to constitute a definite health hazard. This
possibility is made more  likely by the greatly
increased use of  asbestos since the  occur-
rence of the  exposures  which are only now
leading to the development  of mesotheliomas.
A  series of autopsies has shown that an ap-
preciable fraction (20 percent to 50 percent)
of the  population at large  has "asbestos
bodies" in its lungs. More detailed discussions
of both  asbestos 2 and  beryllium3 toxicity
may be found in recent reviews.
  Several other  potential  carcinogens  are
known to be present  as  relatively minor at-
mospheric pollutants; these may be particu-
late  in nature,  and  they  are  discussed in
Section D.

         2.   Adsorbed  Substances
  Toxic substances may be adsorbed on the
surface of particulate  matter, which may
then carry the toxic principle into the respi-
ratory system.  The presence of  carbon or
soot as a common particulate  pollutant is
noteworthy, as carbon is well known as an
efficient adsorber of a wide range of organic
and inorganic compounds. Some specific stud-
ies involving mixtures of particulate matter
and  irritant gases are presented in Section
C-3; the present section  is concerned mainly
with the general principles of adsorption and
desorption.
  The role played by the affinity for the ad-
sorbate by the particle is complex. A high af-
finity will mean that relatively large loads of
adsorbate may be carried by each particle. If
the adsorbate in its free  state is slowly re-
moved from the air in the respiratory system,
then the deposition of particles carrying high
concentrations may constitute a greater toxic
hazard,  especially at the localized deposition
points. Whether or not the effect is  signifi-
cant depends on the efficiency of the desorp-
tion and elution process relative to that of the
clearance  process.  The chemical nature  of
both adsorber and adsorbate,  and the size of
the adsorbing particle, all play a part in de-
termining these various efficiencies, and each
system will show its own individual charac-
teristics. Carcinogens, which may produce
their  effect only  after long or repeated ex-
posure, present a particularly involved situa-
tion, because it is not clear whether slow re-
lease  of small concentrations of the carcino-
gen is more dangerous than the rapid release
of larger  quantities.  Experimental evidence
on the elution of a specific series of carcino-
gens is described in Section D-2.

 3.   Reduction of  the Toxicity  of Irritant
                   Gases
  The finding that a preexposure to particu-
late  material  will  tend  to  protect animals
against  the action of an irritant gas is not an
uncommon one.
  Pattle and Burgess " found that, with mice
and guinea pigs, the previous inhalation of
smoke reduced the toxicity of sulfur  dioxide
 (measured in terms of the dosage required
to produce death). They postulated that the
reduced toxicity of SOo produced by preex-
posure to  smoke was due either to the action
of the smoke in reducing the volume breathed
 (and  thus the S02  dose  received), or to a
stimulation of secretions which may  protect
the mucosa from the irritant action of the
gas. This explanation is given weight by their
findings that increased toxicity resulted from
the administration of mixtures of smoke and
sulfur dioxide. A similar study by Salem and
Cullumbine 5 indicated that the effect of kero-
sene  smoke on the toxicity of irritant sub-
stances  depended to some extent on the spe-
cies of animal, although the toxicity of acro-
lein and acetaldehyde seemed to be decreased
in most cases.
  Wagner et  al.® observed that  the preex-
       130

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posure  of  mice to oil mists would protect
against the later action of inhaled ozone and
nitrogen dioxide. The greatest protection was
obtained when  the  oil mist was given 18
hours prior to the exposure to the  irritant
gas; when  the oil mist and irritant gas were
given together, there was an enhancement of
toxicity. The relative degree of  this enhance-
ment was consistent with the known depth of
penetration of nitrogen dioxide and ozone in
the respiratory tract and the relative solubil-
ity of the two gases in mineral oil. The hy-
pothesis for the protective  action of the pre-
treatment with oil is the formation of an oil
film on the aveolar surface.
  Again- Amdur and  Devir,7  using guinea
pigs, have  observed that the presence of an
aerosol  of 2.5/* triphenyl-phosphate particles
at a concentration of 50 mg/m3  to 100 mg/m3
lessens  the increase in pulmonary  flow  re-
sistance due  to inhalation of sulfur  dioxide.
They then studied the eifect  of treatment
with the particulate material  before expo-
sures to sulfur dioxide alone. This sequence
afforded excellent  protection against the re-
sponse to the sulfur dioxide, and the degree
of protection was related to the total amount
of aerosol inhaled.

    C.   TOXICOLOGICAL  STUDIES OF
  SPECIFIC PARTICULATE MATERIALS

  1.  Pathological Studies  of  Smoke and
             Carbon Particles
  Smoke from burning bituminous coal was
used for a study on  rabbits  and  rats by
Schnurer and Haythorn.8 Four rabbits and
eight rats  were exposed for periods of 80
days to smoke with a concentration of 125
million particles/ft3  (4410 particles/cm3), of
which 8 percent was free Si02. Control ani-
mals received clean filtered air. One control
rabbit and  two exposed rabbits  died of bron-
chial pneumonia before the end of the expo-
sure. One rabbit and six rats were autopsied
immediately after  exposure, and the rest at
intervals up to 429 days. Lesions typical of
nonoccupational  anthracosis were noted in
the lungs of  the animals killed immediately
after exposure,  while  fibrous  reactions de-
veloped  around the carbon deposits (with the
formation of collagen strands) in the animals
that were examined several months to a year
after the exposure.  The authors state that
these lung changes were analogous to those
seen in a milder grade of bituminous  pneu-
moconiosis of soft-coal miners, and they also
concluded that  the pneumonitis  and fibrosis
were attributable  to the carbon  rather than
to the small amount of silica present.
  Schnurer h has also attempted to compare
the response to the burning of equal weights
of anthracite coal, coke, and bituminous coal.
Unfortunately,  widely differing particle con-
centrations were obtained from burning equal
weights  of  fuel,  so  that it is impossible to
place any  simple  interpretation on the re-
sults of the experiments.
  Pattle et al.w studied the acute toxic effects
of smoke, generated by burning tetrahydro-
naphthalene in  the  concentration range  of
700 mg/m3 to 1100 mg/m3. They found that
the median dosage to death for  guinea pigs
and mice lay between 147,000 mg—min/m3 to
351,000 mg—min/m3. In mice, the cause of
death was blockage  of the air passages and
delayed  death resulting from the exposure
was  unusual. The guinea pigs showed hemor-
rhagic lesions, and delayed deaths were more
common. The action of smoke  on rats  re-
sembled  that on mice. No data are provided
to show that unburnt tetrahydronaphthalene
did not enter the smoke stream in these ex-
periments, since toxic effects are well known
for this substance.
  In the course of a study of mixtures  of
sulfur dioxide and smoke, to be discussed in
Section C-3, Pattle  and Burgess *  reported
some data on the effect of smoke alone on
mice. The smoke was generated by a burning
kerosene lamp,  and its concentration was
about 50 mg/m3. The experiment continued
for 36 hours followed by a gap of 11 hours.
The  experiment was subsequently continued
for 30 hours. There were no  fatalities and
none occurred after  the experiment.  Histo-
logical examination of the lungs shewed that
at the end of exposure the soot particles were
partly  spread over the lining of the bron-
chioles and alveoli and partly aggreg ated into
patches.  There were  no signs of edema, con-
solidation, hemorrhage,  or emphysema' and
capillary congestion  was slight. The lungs
were normal except for the presence of car-
                                                                            131

-------
bon particles, and animals killed 3 months
after  exposure  showed phagocytosis  and
gradual clearance of smoke from the lungs.
  Salem and Cullumbine5  also  make brief
mention of the exposure of mice and guinea
pigs to smoke from a  kerosene lamp. The
animals survived exposure  to 664 mg/m3 of
smoke for 6 hours, and autopsy revealed no
obvious damage to the lungs.
  The physiological  effects on mice  of ex-
posure to carbon black by ingestion, skin con-
tact, subcutaneous injection, and inhalation
were  examined  by  Nau et aZ.11-"  Channel
black (particle diameter 0.025//,) and furnace
black (particle diameter 0.035/x.) were used in
concentrations of 2.4 mg/m3 and 1.6 mg/m3
respectively for  the inhalation experiments.
Mice, hamsters, guinea pigs, rabbits, and
monkeys were exposed for prolonged periods
to the dust, but  no effect other than the ac-
cumulation of carbon particles in the lungs
was demonstrated.
  The problem of whether exposure of rats
to coal dust or smoke would alter their sus-
ceptibility to infection  by  Type I pneumo-
cocci  was examined by  Vintinner and Baet-
jer 15  as part of a series of studies on the ef-
fect of fibrous, inert,  and adsorptive dusts on
susceptibility to infection  in experimental
animals.16-18 The concentration of  coal dust
varied between 400 and 850  million particles/
ft3 with an average of 700 million particles/
ft3. The smoke level  in  the chambers would
have  been  considered as "dense" on visual
inspection, or equivalent to about a Number
3 reading on the Ringelmann Chart. Analyses
of the particulate matter  in mg/m3  in the
smoke chamber  averaged as follows:  Total
solids—570,  carbon—470,  ash—93, silica—
46, iron—15, and  sulfur—9, that is,  about
100 times the values listed  as "average com-
position of susupended dust during the win-
ter months  for all  cities." The exposures
ranged from 5 days to 165 days for the bitu-
minous coal dust and from 2 days to 154 days
for the smoke. On the basis  of their extensive
data,  the authors concluded that the inhala-
tion of smoke did not alter  the susceptibility
to infection  when the organisms,  either in
broth or in mucin, were administered by in-
trabronchial  injection. The bituminous coal
dust seemed to exert a slight protective effect
when the organisms were suspended in mucin
but not when they were injected in a broth
medium.
  Based upon the reported studies, smoke or
carbon black on its own apparently produces
little major damage to the respiratory system
of animals  even at  exposure levels some
orders  of magnitude greater than those en-
countered in polluted atmospheres.

  2.  Physiological Studies of Response
          to Particulate Material
  Certain particulate  materials are pulmon-
ary irritants which have been shown to pro-
duce alterations  in the mechanical behavior
of the  lungs, the alteration being predomi-
nantly  an increase in flow  resistance. This
was  demonstrated by Amdur 19 for sulfuric
acid, and by Amdur  and  Corn20 for am-
monium sulfate, zinc sulfate, and zinc am-
monium sulfate, using the guinea pig as an
assay animal. (The decreased flow rates ob-
served  by Amdur, Silverman, and Drinker 21
in human subjects  exposed  to sulf uric acid
mist probably reflect an increase in flow re-
sistance, although, since the resistance was
not measured in those experiments, such a
statement cannot be conclusive.) A series of
papers making use of the increase in pulmon-
ary flow resistance as an assay tool has been
published by Amdur,22-27 and "response" to
an irritant in discussion of her work general-
ly refers to this increase.
  Nadel et al.z* report a correlation between
the alterations in pulmonary mechanics and
actual anatomical change in cats exposed to
aerosols of  histamine and  zinc ammonium
sulfate. The  authors discuss the physiological
mechanisms which may operate  to bring
about  such  alterations in  pulmonary  me-
chanics.
  In connection with a study of the effect of
various aerosols on the increase in pulmonary
flow resistance  in  guinea pigs produced by
sulfur  dioxide, Amdur and Underhill22 first
examined the response to the aerosols alone.
These aerosols included spectrographic car-
bon at  2 mg/m3 and 8 mg/m3, activated car-
bon at 8.7 mg/m3, manganese dioxide at 9.7
mg/m3, open hearth dust at 7.0 mg/m3, iron
oxide (Fe203) at 11.7 mg/m3 and 21.0 mg/m3,
manganous  chloride and ferrous sulfate at
       132

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 1  mg/rn3- and sodium orthovanadate  at 0.7
 mg/m3; the particle sizes were less than 0.5/*.
 Standard one-hour exposures were used in
 this routine bioassay method, with the ex-
 ception of the iron oxide exposures,  which
 were extended to two hours. In no instance
 did any of the aerosols produce an alteration
 in flow resistance. The failure of the aerosols
 to produce an increase in resistance in these
 experiments suggests that if they cause bron-
 chial constriction, it must be only in extreme-
 ly high  concentrations.  From the point of
 view of air pollution toxicology, none of them
 would be classed on this basis as pulmonary
 irritants. An uncharacterized "fly ash" from
 an oil-fired burner was also tested and proved
 inert.
   At a concentration of 1 mg/m3, ferric sul-
 fate aerosol produced a 77 percent increase in
 flow resistance in  a group of 15 animals
 which was statistically significant at the level
 of P<0.001. Ferric sulfate, in distinction to
 ferrous sulfate, must be  classed as an irri-
 tant.
   On the other hand, Dautrebande and Du-
 Bois 29'30 have reported constriction and in-
 creased airway resistance in isolated guinea
 pig lungs and in human subjects with a wide
 variety of supposedly "inert" particulate mat-
 ter. The relationship of their results to Am-
 dur's work is not clear since Dautrebande's
 particle  concentrations  appear to  be  ab-
 normally high. Total  lung capacity and vital
 capacity were  not altered by  the inhalation
 of particulate  material in healthy  subjects,
 but the vital  capacity in  patients with pul-
 monary disease was reduced by the inhala-
 tion of particulate materials. It is interesting
 in this connection that guinea pigs with an
 initially  high  pulmonary  flow  resistance
 showed a greater  response to low concen-
 trations of irritant  aerosols or of inert aero-
 sol-irritant gas combinations  than animals
 with average control flow resistance values.31
  The possibility that the conflict between
Amdur's and  Dautrebande's work may be
 resolved  in  terms of the doses involved is
 given credence by studies which suggest that
human response to coal dust may  be  dose-
related.32 Coal dust  clouds similar to those in
mines  have been produced in the laboratory,
and the number and weight of respirable par-
ticles have been measured. Clouds containing
8 mg/m3, 9 mg/m3, 19 mg/m3, 33 mg/m3, and
50 mg/m3 dust in the size range of I/* to Ip
were used. Normal subjects inhaled the dust
for 4 hours, and airway resistance was meas-
ured with a body plethysmograph. No chang-
es were obtained after the inhalation of  coal
dust from clouds containing  8  mg/m3  or 9
mg/m3; but with concentrations of 19 mg/m3,
33  mg/m3. and  50  mg/m3,  significant  in-
creases in airway resistance occurred  and
the response was correlated with the quan-
tity  of dust. One hour after exposure ceased,
the airway resistance was about two-thirds
back to normal. With the two highest concen-
trations,  the  respiratory  rate  increased
throughout the  4 hours,  and subjects com-
plained of difficulty in breathing after one to
two  hours. It would appear that if 8 mg/m3
or 9 mg/m3 produced no lung function change
in a 4-hour period, the material  (cold dust)
and perhaps other "inert" particulate matter
would be unlikely to do so at any concentra-
tions likely to occur in air pollution. In Chap-
ter 1, Table 1-2 shows a maximum geometric
mean concentration of urban particulates in
1961 to 1965 of 180 ^g/m3.
  Particle size may "play an important  part
in determining  the  potency of  an  irritant.
For  example, at a mass concentration of 1.4
mg/m3 to  1.9  mg/m3, sulfuric acid mist of
0.8/i  produces  a 51 percent increase in pul-
monary  flow resistance in guinea  pigs as
compared to control  values,19 and  zinc am-
monium sulfate  particles of 0.84//, produce a
21 percent increase.25 If the zinc ammonium
sulfate size is 0.3/x'  the  corresponding in-
crease in pulmonary flow resistance is  130
percent.20 The  studies  on  zinc ammonium
sulfate  were  carried out  by Amdur  and
Corn 20 with nonhomogeneous aerosols with
mean sizes by weight of 0.24/*, 0.51/j., 0.74^,
and  1.4/x,  at several  concentrations. As  the
particle size decreased  over the range  1.4ju
to 0.29/*,  the response to an equal mass  con-
centration rose.  When dose-response curves
of percent increase in flow resistance against
concentration in mg/m3 were plotted for the
different particle sizes,  the slopes increased
as the particle size decreased. A similar study
was  undertaken  by  Amdur and  Creasia33
using m-terphenyl as  the aerosol (size range
                                                                             133

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0.3/* to 2.0^); this aerosol does not absorb
water  during passage through the respira-
tory tract. An essentially, identical pattern to
that  seen  for   zinc  ammonium  sulfate
emerged, with the irritant potency increasing
with decreasing particle size, and the slopes
of  the dose-response curves  steeper than
those for the smaller particles. All of the
particles  used  in these  studies fall within
the "respirable size range." The possible im-
plications for air pollution are:
     1. Particles below lju. may  have greater
       irritant potency than larger species,
       and
    2. A  small  increase in  concentration
       could produce a  greater-than-linear
       increase  in irritant  response when
       the  particles  are  smaller  than  1^.
  The effect of  particulate matter on clear-
ance  mechanisms  has already been  men-
tioned.  The  deposition of  particles affects
mucous secretion and  ciliary  action  most
markedly   at branchings;   e.g.,  miniature
ridges throughout the tracheobronchial tree
as contrasted with intervening  areas, and it
is in the  ridge areas that alterations in the
morphology are  initially most intense and
prolonged  and ultimately irreversible.  The
adverse effect is  manifested  by a slowing  of
the flow of the mucous stream,  alteration  in
the  physical  and  chemical properties  of
mucus, and changes in ciliary action.
  Examination  of sections  of respiratory
epithelium removed from the  lungs  reveal
hyperplastic  and metaplastic changes  earli-
est at  these sites. The exaggerated effect  of
                    the impingement of irritants on respiratory
                    epithelium at branch points  taken together
                    with less efficient clearance is consistent with
                    this result. Thus, abnormal retention and ac-
                    cumulation of soot (and possibly carcinogenic
                    particles) may occur, especially in segmental
                    bronchi. The  accompanying  peribronchial
                    and peribronchiolar  inflammatory  response
                    further interferes with physiologic mechan-
                    isms of defense.
                       Experimental confirmation of enhanced re-
                    tention in the presence of irritant material
                    is to be found in the  work of Tremer et al.,3i
                    who exposed rabbits first to synthetic smog
                    and then to soot. The results are shown in
                    Table  10-1.
                       The main conclusions of this section are:
                        1. The  predominant  physiological effect
                           of irritants is to increase pulmonary
                           flow resistance;
                        2. Exceptionally heavy  loads  of rela-
                           tively inert particles may cause some
                           increase in flow resistance; and
                        3. The  intensity of physiologic response
                           may increase with a decrease in par-
                           ticle size for  any  given irritant.

                     3.  Experimental Studies of Mixtures  of
                       Irritant Gases and Particulate  Material
                       The possible influence of inert particulate
                    matter on the toxicity of irritant  gases has
                    been  the subject  of considerable specula-
                    tion 3r>-37 and a limited amount of experimen-
                    tal work.  Such  interaction  of gaseous and
                    particulate  pollutants might  be  important
                    to understanding the complicated toxicologi-
                    cal picture of the air  pollution disasters.
Table lfr-1.—EFFECT OF EXPOSURE OF RABBITS TO 2 PPM OZONIZED GASOLINE ON RETENTION
                                    OF INHALED SOOT.
Specimen
  Smog
exposure,
  hours
 Room air
(recovery),
  hours
  Soot
exposure,
 hours
Room air
(recovery),
  hours
Soot in
 lung,
 mg
No recovery period after smog exposure:
    Control    ..               0
    Animal No. 1               1
    Animal No. 2 . .             1
With varying recovery periods:
    Control  .  .        .        0
    Animal No. 1	        1
    Animal No. 2	      1
    Animal No. 3  ...        1
                0
                0
                0

                0
                4
                8
               24
                              0
                              0
                             24

                              0
                              0
                              0
                              0
                              3.7
                              7.9
                              5.4

                              1.1
                              7.4
                              5.2
                              2.0
       134

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  The first experimental  evidence  that  an
inert aerosol could alter the response to  an'
irritant gas was presented in 1939,38 when
it was reported that concentrations  of mus-
tard gas which were relatively harmless to
rats would produce pulmonary edema and
death  when administered in  combination
with an inert aerosol (sodium chloride).  It
was postulated that the  adsorption of gas
on  the particles had increased the  amount
of  irritant vapor reaching the critical tar-
get areas of the lung.  Dautrebande and his
co-workers 39> 40 studied the sensory response
of human  subjects to pollutants thought to
be constituents of the Los Angeles smog and
found that the presence of particles of so-
dium chloride, oil mist,  or smoke,  increase
the irritation of eye, nose, and throat by sul-
fur dioxide, formaldehyde,  and other gaseous
pollutants.
  LaBelle  et al.*1 studied the effect of par-
ticulate matter on the survival time of mice
exposed to formaldehyde,  acrolein,  and  ox-
ides of nitrogen. The particles used included
triethylene glycol, ethylene glycol,  mineral
oil, glycerin, sodium chloride, two commer-
cial filter  grades of diatomaceous earth, and
a commercial  silica gel.   From theoretical
considerations, the probable percent penetra-
tion of the upper respiratory tract by vari-
ous gases was calculated.  If  the  gas pene-
trated to a greater extent than the particles,
then adsorption  on the particles  would  de-
crease the amount of irritant  gas reaching
the lungs and  the toxicity would decrease.
Such a situation exists with oxides of nitro-
gen. Conversely, if the gas did not readily
penetrate  the  upper respiratory  tract, ad-
sorption  on small particles would  tend  to
carry more gas  to the lungs  and thus  in-
crease the toxicity.  Such a situation exists
with formaldehyde. The theoretical  calcula-
tions coincided with experimental results  in
over 70 percent of the gas-particle combina-
tions. The theory partially explains the po-
tentiation  of irritant gases by particulate
material  (often termed a synergistic effect),
but subsequent research has shown that the
problem is not as simple as  had been  as-
sumed.
  A synergistic effect was reported  by Dal-
hamn and Reid42 with ammonia and carbon
particles. Ammonia is a highly soluble gas,
so that synergism would have been predicted
by  LaBelle et a/.41  Rats were exposed for
60 days to 100 ppm ammonia alone, 7 mg/m3
carbon alone, and to 119 ppm ammonia plus
3.5  mg/m3  carbon.   The  carbon particles
were 95  percent  smaller than 3 /* and  65
percent smaller than 1 p.  In the group ex-
posed to both ammonia and carbon, there was
a high frequency of mucosal damage, and the
ciliary  activity seemed to be  significantly
impaired.  The  trachea of  rats  exposed to
ammonia alone  showed  less severe damage,
and the trachea was histologically normal in
about 80 percent of the rats exposed to car-
bon alone.
  Boren " exposed mice to carbon alone, to
nitrogen dioxide,  and  to carbon which had
previously been exposed to nitrogen dioxide.
He stated that  around 550 mg of nitrogen
dioxide was  adsorbed  per gram of carbon.
Samples of air taken from the chamber dur-
ing the exposure of mice to carbon with ad-
sorbed nitrogen dioxide indicated that there
was about 25 ppm to  30 ppm free nitrogen
dioxide. Although this is a high concentra-
tion of nitrogen dioxide, mice exposed to even
higher  concentrations  (250 ppm)  of nitro-
gen  dioxide alone  developed pulmonary ede-
ma,  but  neither  single nor  repetitive ex-
posure  produced parenchymal lung lesions.
Control mice and  mice exposed  to  carbon
alone showed no  anatomic abnormality  of
the lungs.  Mice exposed to the carbon  with
adsorbed  nitrogen dioxide  developed focal
destructive  pulmonary  lesions.  The expo-
sures in this group were 6 hours per  day,
5 days a week, for 3 months.
  The typical lesions  of pneumonitis were
observed  by  Gross et  al.4t  in the lungs  of
hamsters, rats,  and guinea pigs exposed to
a "sufficiently large number of carbon  par-
ticles with either adsorbed sulfur dioxide or
nitrogen dioxide."  Exposure  was 8 hours
per day, 5 days  per week, for 4 weeks.  The
particle size  of the carbon, and the meaning
of the  phrase  "a  sufficiently  large  number
of carbon particles" were not  given. There
was  no record of  the  amount  of either gas
adsorbed by  the activated carbon particles.
Histological  sections  were  from animals
killed about  a month  after the  end of ex-
                                                                             135

-------
posure, whereby it is concluded that the le-
sions were  persistent.  They were concen-
trated in the regions of the respiratory bron-
chioles  and  alveolar dusts and consisted of
cellular wall thickening.
  Pattle and Burgess 4  studied the effect of
mixtures  of sulfur dioxide  and  smoke  on
mice and guinea pigs. Their concentrations
of sulfur dioxide were in the range of 2,700
mg/m3  to 12,000 mg/m3  (900 ppm to 4,000
ppm), and the smoke concentrations were in
the range of 50  mg/m3 to 135 mg/m3.  Their
end point was the dosage required to produce
death.  With concentrations  of  this magni-
tude, the results obtained have little  appli-
cability to air pollution criteria.   Although
they found that the lethality of mixtures of
sulfur dioxide and smoke was greater than
the lethality of the sulfur dioxide alone, they
considered the effect to be a  simple additive
one  resulting from the  action of  smoke in
blocking the bronchi and alveoli.
  Salem and Cullumbine 5 studied the effect
of kerosene smoke on the acute toxicity of
sulfuric acid, sulfur dioxide, acrolein,  and
acetaldehyde in guinea  pigs,  mice, and rab-
bits. As in the work by Pattle and Burgess,4
the  concentrations were  many magnitudes
above those found in air pollution episodes.
The  administration of  smoke prior  to the
exposure  to the  irritant substances did not
alter the toxicity, although the  effects of
smoke on the toxicity of the irritants were
highly variable  when the two agents were
given  simultaneously.   In guinea  pigs, the
toxicity of sulfuric acid was increased by the
presence of smoke, the toxicity of acetalde-
hyde and sulfur dioxide was decreased, and
the toxicity of acrolein was unchanged.  In
mice, the toxicity of sulfur  dioxide was in-
creased, while that of acetaldehyde and acro-
lein  was decreased. In rabbits, the toxicity
of acrolein  and  acetaldehyde was decreased
by the smoke. The end point in all cases was
the mean fatal dose.
  A  series of studies of the  effect of hygro-
scopic particles  on physiological response to
irritants has been undertaken by Amdur,22-27
using the pulmonary  flow resistance tech-
nique.  It was found initially that the re-
sponse to sulfur dioxide was potentiated by
particles of sodium chloride below 1 p, but
not by 2.5-/U particles,  at concentrations of
about 10 mg/m3. With sulfur dioxide 24 and
with formaldehyde 25 as irritants, decreasing
the concentration of the aerosol, or the total
dose of aerosol  by  shortening  the exposure
time,22 decreased the degree of potentiation
observed from the addition of sodium  chlo-
ride.  The hypothesis of LaBelle et a£.41 that
irritant  gases with  high  water solubility
would  be potentiated by particles  did not
explain adequately  the data obtained.  Sul-
fur dioxide, formaldehyde,  acetic acid,  and
formic acid all  have high  water solubility,
but it was found that the first two were po-
tentiated  by sodium  chloride 23>24  and that
the latter two were not.25-27 Although both
sulfur dioxide and formaldehyde were po-
tentiated by sodium chloride, there are dif-
ferences  which  suggest  that the  guiding
mechanism in the case of sulfur dioxide may
be  chemical  change  and  for formaldehyde
may involve  surface  adsorption.24
  Another paper -  examines further the ef-
fect of various physical and chemical factors
on the potentiation  of sulfur dioxide by par-
ticulate material. The degree of potentiation
observed could be correlated to some extent
with the solubility  of sulfur dioxide in the
solutions of sodium chloride, potassium chlo-
ride, and ammonium thiocyanate.
  Aerosols of soluble salts  of  ferrous  iron,
manganese,  and vanadium,  which had been
shown by Johnstone  and  co-workers45-46 to
be  capable of catalyzing  the conversion of
sulfur dioxide to sulfuric  acid  when  they
were  present  as nuclei  of  fog  droplets,
showed a major potentiating  action where
present at concentrations  of about 1 mg/m3.
On the other  hand, dry manganese dioxide,
activated or spectrographic carbon, iron ox-
ide fume, open  hearth dust,  and triphenyl
phosphate did not  alter the response  even
when present in concentrations of 8 mg/m3
to 10 mg/m3.
  It is clear from the data  presented 22 that
all  particulate material does not  potentiate
the response to sulfur dioxide any more than
one particulate  (sodium  chloride)  has po-
tentiated the  response  to all  irritant gases
tested. Both solubility  of sulfur dioxide in
a droplet and catalytic  oxidation to sulfuric
acid play a major role in the observed poten-
       136

-------
tiation of sulfur dioxide by certain particu-
late matter.

          D.  CARCINOGENESIS

             1.  Carcinogens
  The incidence of cancer, and the insidious
nature of the onset of malignant cell activity,
together make essential the utmost effort in
determining whether factors associated with
air pollution can lead to increased occurrence
of lung cancer in susceptible individuals, or
to increased  susceptibility to cancer in the
population at large. In various parts of the
world, and especially in the United  States,
the relative mortality due to lung cancer has
been increasing.47 Furthermore, urban resi-
dents exhibit  a greater  liability to the de-
velopment of lung cancer than  do those liv-
ing in rural  areas,48 and data from several
investigations suggest that the epidemiologi-
cal association between urban residence and
lung  cancer  is  of  pathogenetic signifi-
cance.49"51 The association between lung can-
cer and  cigarette smoking is  too well docu-
mented to need  further amplification  here.
There is, however,  one  feature common to
both  air pollution  and   cigarette  smoking
studies  which should be emphasized.  In no
case, for the reasons explained  in the intro-
duction to this chapter, has a suspected car-
cinogen  in fact  been demonstrated experi-
mentally to produce a lung  tumor in  man,
although the epidemiological  considerations
to be developed in the next chapter may well
show  a significant association  between the
suspected material and  cancer.  Thus, sub-
stances such as the polynuclear aromatic hy-
drocarbons (of which benzo(a)pyrene,  BaP,
is the prime example) may or may not pro-
duce  lung cancer in man.  However,  they
do  increase tumor  incidence in laboratory
animals and, in addition, have produced ma-
lignancies  when  in combination with spe-
cific particles  or viral infection. The mini-
mum  possible risk should always  be  taken
with a potentially toxic substance whose ef-
fect may appear after a long period  of la-
tency.  The bulk of the ensuing discussion is
therefore based on the hypothesis that carci-
nogens effective  in animals may be signifi-
cant in increasing  human malignant tumor
incidence, and the word "carcinogen" will
be used without qualification.
  A portion of the organic material present
in the  atmosphere  as suspended  particles
(Table  1-2) may be carcinogenic, and carci-
nogenic materials have been identified in the
atmosphere  of virtually all  large  cities  in
which studies have been conducted.  The in-
complete combustion of organic matter is one
of the major sources of such substances; the
photochemical reaction products of aliphatic
and  aromatic constituents of gasoline in the
presence of  the atmospheric gases also pos-
sess  some potency for generating tumors ex-
perimentally.
  Chemical  and physical studies  of polluted
urban air have been paralleled by carcino-
genic investigations using skin painting, sub-
cutaneous  injection,   and  inhalation tech-
niques.  The carcinogenicity  (as measured
by these  techniques)  of extracts of mate-
rials collected from air as  well as such pol-
lutant sources as chimney soots,  road dusts,
and  vehicular exhausts, has been established
by many  investigators.  It should be noted
first that, in many cases, use  was made of
mice (A-strain)  particularly susceptible to
tumor development; and second, only two of
the  studies,  those involving ozonized gaso-
line, used inhalation as a route o'f  adminis-
tration.  The observed response in  the case
of A-strain  mice inhaling ozonized gasoline
was  the relatively rapid development of mul-
tiple adenomas in the lung which,  although
tumors, are not malignant.52
  More recently, sequamous  cell cancers of
the lung were induced in C57 black mice fol-
lowing  infection  with  influenza virus and
continuous exposure to an aerosol  of ozon-
ized  gasoline.  The  tumors  produced were
histologically identical with  those  observed
most frequently in man.53
  Measurable concentrations  of  inorganic
substances, such as metal dusts and asbestos,
demonstrated to be occupationally associated
with  increased liability to lung  cancer de-
velopment, are also  emitted  into the atmo-
sphere.54"60  Additional  laboratory   experi-
mentation is needed to verify such carcino-
genic potential relative to interacting effects
and  respective ambient atmospheric concen-
trations.
                                                                             137

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2.  Polynuclear Aromatic Hydrocarbons  as
   Carcinogens in Polluted Atmospheres
  Polynuclear  aromatic  hydrocarbons are
commonly regarded  with extreme suspicion
as possible  carcinogens,  and much  of the
experimental work performed has concerned
these compounds. This section  deals with
the presence and stability of the hydrocar-
bons in the  atmosphere, and with their elu-
tion  from soots on which they may be ad-
sorbed.
  The  concentration   of  benzo(a)pyrene
(BaP) as a representative carcinogenic hy-
drocarbon in  selected  urban  and nonurban
areas within the United States is shown  in
Table 10-2;61 in Table 10-3,62 the benzo(a)-
pyrene content is given as a fraction of the

Table  10-2. — BENZO(A)PYRENE  CONCENTRA-
  TIONS IN SEVERAL URBAN AND NONURBAN
  AREAS.
    State
                            BaP/lOOOm3 air
                       Urban
Nonurban
Alabama
Indiana
Maryland
Missouri
North Carolina
Oregon
Pennsylvania
South Carolina
24
39
14
54
39
8
61
24
0.076
1.8
0.70
0.025
0.25
0.01
1.9
1.1
Table 10-3.— BENZO(A)PYRENE AS A FRACTION
  OF THE TOTAL  AROMATIC HYDROCARBON
  CONTENT  OF  SEVERAL  URBAN  ATMOS-
  PHERES
    City
                      BaP fraction of
               total aromatic hydrocarbon,
                   Lot 19
Lot 20
Atlanta
Birmingham
Cincinnati
Detroit
Los Angeles
Nashville
New Orleans
Philadelphia
San Francisco
1,800
2,300
2,800
3,800
660
5,900
2,100
2,500
680
1,900
3,400
5,200
4,500
260
4,900
1,600
?
290
total  aromatic hydrocarbon  content  of air
pollutants of nine American cities.
  The physical stability of aerosols in pol-
luted atmospheres has already been described
in general terms (Chapter 1).  Chemically,
benzo(a)pyrene seems to be relatively stable
and, even in the presence of a strongly oxi-
dizing atmosphere, such  as that found  in
photochemical  smog  characteristic  of Los
Angeles, the rate of  disappearance  of ben-
zo(a)pyrene is smaller than  that of  many
other hydrocarbons.  Table 10-4 63 shows the
destruction  under certain  conditions of ex-
posure of various polynuclear aromatic hy-
drocarbons present in air.
  Polynuclear  aromatic hydrocarbons  may
exist in the atmosphere adsorbed on carrier
particles as well  as in their free state. As
was mentioned in Section C-2, in the respira-
tory system, particle size  influences the rate
and extent  of elution of  adsorbates either
into the macrophages,  or  onto the respira-
tory epithelium.  Polycyclic aromatic hydro-
carbons cannot be readily  eluted from soots
of very small  particle  size; in fact, particles
with an average diameter of less than 0.04 /*
will remove these compounds from their im-
mediate  environment  because  of high sur-
face adsorption. Particles above 0.04-ju, aver-
age size range will generally release adsorbed
aromatic  polycyclic  hydrocarbons  in  the
presence of appropriate solvents, which in-
clude plasma  and cytoplasmic proteins. As
particle size increases, release becomes more
rapid and greater in  extent. The elution of
polycyclic aromatic hydrocarbons from 0.5-//,
soot particles  after incubation with plasma
for various  time intervals is shown in Table
10-5.64
  In  studies  on  skin  carcinogenesis,  Falk
and  Steiner,65  using  commercial  carbon
blacks, related the biological activity of ad-
sorbed carcinogens to  the size of  the soot
particle and the presence of natural eluting
substances at the site of  deposition.  They
advanced the  principles of natural and con-
ditional carcinogens, of solvent elution, and
of  adsorption, to explain some clinical and
epidemiological observations of human skin
and lung cancers, and of the role of preced-
ing pathological  lesions in predisposing to
pulmonary tumors.
       138

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Table 10-4.—EFFECT OF VARIOUS CONDITIONS OF EXPOSURE ON THE DESTRUCTION OF SOME
                         POLYNUCLEAR AROMATIC HYDROCARBONS
                                                   Percent destroyed
                                Pure unadsorbed
                  Adsorbed on soot
Hydrocarbons



Compound X
Anthanthrene
Phenanthrene
Pyrene
Fluoranthene . 	
3, 4 Benzpyrene
1, 2 Benzpyrene .
1, 12 Benzperylene
Coronene
Chrysene
By
air
in dark

24
100
.. 44
39
24
	 17
0

0
0
0

48

49
61
43
20
0

0
0
0
By air
in

24
100
42
34
20
16
21

0
0
11
light

48

44
60
42
24
22

0
0
0
By smog
in light
Hours
1
100


83
59
50

27
5
15
By air
in light

48
12
5

1
4
10
7
0



By smog

1
72
55

58
59
18
51
67


   The interaction of carcinogens with other
particulate agents  has been studied toxico-
logically,  utilizing  laboratory animals.  Ex-
periments have shown that the addition of
seemingly inert particulates to carcinogens
results in the production of malignant neo-
plasms  in the lung.  Pylev66 produced  an
appreciable incidence of lung cancers in rats
by the intratracheal administration of 9,
10-dimethyl-l, 2 benzathracene (DMBA)  in-
corporated with india  ink  in  a 4-percent
casein solution, whereas Gricute67 was  un-
successful with the same material when it
was suspended only  in physiological saline.
Saffiotti6S'69 has  produced a variety  of ma-
lignant tumors in the lungs of hamsters by
intratracheal  instillation of saline  suspen-
sions of BaP ground together with hematite
(Fe^Os) as a carrier dust in amounts equiv-
alent to 3 mg of each chemical, once weekly
for 15 injections. Not only was a high  in-
cidence of lung  cancers produced but also
these lung cancers  mimicked all the various
cell types seen in human cancers, i.e., squa-
mous cell carcinoma,  anaplastic  carcinoma,
adeno-carcinoma, and even tracheal cancers.
Dose-response  effects  were  suggested,  as
were indications that a single  high dose
could induce cancers in this system.69  Ac-
cording to Saffiotti et al.''0 the increased ac-
tion for  the  carcinogen is thought  to  be
brought  about by its adherence to the  fine
inert particulate which in  turn  carries  it
through   the  respiratory   bronchioles  and
alveoli into the lung parenchyma.  The carci-
nogens may then be eluted from the particu-
lates and spread diffusely to reach the target
tissue. They infer that there is  also a re-
duction in the speed in which BaP  is re-
moved from the respiratory tract brought
about by the hermatite  dust.  Shabad et al.71
have reported that when india ink was in-
cluded in the inoculum, BaP was eliminated
more slowly from the lung. One  must con-
sider the possibility that the carrier material
itself might be  contributing some effect.
Faulds and Stewart72 reported increased in-
cidence of carcinoma in the lungs of hema-
tite miners.  However, it is  difficult to assess
the exact role of iron in such a complicated
exposure  situation,  since  silica and  other
dusts are certain  to  be  present.  Bonser
'.it al.73 suggest that iron oxide may play  a
role  in  converting the fibrogenic  effect of
silica into a carcinogenic process.  Haddow
and  Horning 74 have reported that the car-
                                                                             139

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Table 10-5.—PERCENTAGE RECOVERY OF POLYNUCLEAR  AROMATIC HYDROCARBONS FROM 05M
   SOOT  PARTICLES AND FROM PLASMA AFTER INCUBATION WITH PLASMA FOR VARYING
   PERIODS.
Incubation time, hours
Compound
Pyrene

Fluoranthrene

C ompound-X

1 ,2-i . nzpyrene

3 , 4-Benzpyrene

1 ,12-Benzperylene

Anthanthre'ne

Coronene - - 	

Concentration, Fraction

8 4 Soot
Plasma
Total
1 . 0 Soot
Plasma
Total
2 8 Soot
Plasma
Total
2 . 9 Soot
Plasma
Total
1 . 7 Soot
Plasma
Total
9.2 Soot
Plasma
Total
2.4 Soot
Plasma
Total
	 10.0 Soot
Plasma
Total
1.5

9
81
90
trace
100
100
0
100
100
trace
52
52
18
82
100
31
66
97
25
54
79
40
36
76
16
Percentage
34
61
95
present
present
trace
93
93
17
41
58
41
59
100
67
33
100
54
33
87
66
26
92
96
recovery
9
50
59
0
present
0
present
0
21
21
6
23
29
5
15
20
trace
17
17
12
8
20
192

6
61
67
present
present
0
39
39
0
21
21
18
18
36
11
13
24
13
13
20
15
10
25
cinogenic action of an iron-dextran complex
cannot be entirely explained by the dextran
content alone. Consequently, iron cannot be
excluded as a  possible  contributing factor
or cofactor in  cancer production.  Epstein
et aV5  have recently applied methods  em-
ploying the injection of crude benzene-solu-
ble extracts of  atmospheric particulate  into
suckling mice.  The  total dosages adminis-
tered ranged from 5  to 55 mg and produced
a high incidence of tumors in surviving mice
as compared to controls. At 50 weeks post-
inoculation, a variety of tumors was  evi-
dent, the most significant being lymphomas,
hepatomas,  and multiple pulmonary adeno-
mas. In mature mice injected subcutaneous-
ly with carcinogens, the tumors usually de-
velop in the vicinity of the site of inocula-
tion. However, in newborn mice, the tumors
frequently develop at distal points such as
the liver, lungs, or lymph nodes.
  More recently,  Kuschner76  has demon-
strated the interaction of  a known carcino-
gen with the gaseous air pollutant, S02. In-
halation exposures of rats indicated that S02,
alone, produced proliferative and metaplastic
changes in the bronchial epithelium; benzo-
(a)pyrene, alone, failed to cause the develop-
ment of tumors, but the inhalation of benzo-
(a)pyrene in the presence of S02 caused the
       140

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development of bronchogenic squamous cell
carcinoma.

      3.   Pathology of Carcinogenesis

   Rather  little  experimental  evidence  is
available on the pathology of carcinogenesis
following exposure  to air pollutants; much
more experimentation has been carried out
in relation to smoking and lung- cancer.  The
results  of the  extensive work on the latter
topic by Auerbach et al.'11 are reported briefly
because  of the possible similarities between
carcinogenic mechanisms in cigarette smok-
ing and  air pollution. The authors describe
a  series  of changes  which are characterized
by loss  of cilia,  increase in the number  of
cell rows, and  the presence of atypical cells
in the thickened epithelium.  Their findings
suggest  a progression of changes  from ini-
tial  goblet  cell hyperplasia  to  metaplasia,
metaplasia with atypism, carcinoma in situ,
and invasive cancer. Their data further sup-
port the epidemiologic observation of a dose
response to cigarette smoke.  Carnes 78 also
observed a clear and pronounced association
between the extent  of epithelial change and
exposure to  pollutants, and  emphasized the
similarity of epithelial changes in man  to
"hyperplasia and other changes in the bron-
chial  epithelium of mice."  Indistinguishable
histologic counterparts can be  identified  in
both man and experimental animals.
   The sequence of hyperplasia,  metaplasia,
metaplasia with  atypical change, cancer  in
situ, and invasive cancer is likely to occur
first at sites  of impingement and particulate
retention. In experiments with animals, par-
ticle  deposition and retention occur  most
readily  in the  more distal segments of the
tracheobronchial  tree,  a result which ap-
peared at first  to be incompatible with early
clinical and  pathologic observations that pri-
mary bronchial carcinomas originated chiefly
in the main stem bronchi.  Early clinical ob-
servations, however, included a majority  of
cases  in which tumor  size was great  and
point of  origin  was difficult to ascertain, and
recent reports question the concept that most
primary lung cancers are hilar or central  in
origin.  For example, Table 10-6 shows the
distribution of  lung cancer by sites of origin
given by Kotin.79
 Table 10-6.—DISTRIBUTION  OF LUNG CANCER
             BY SITE OF ORIGIN
                                  Percentage
    Site of origin                       of
                                   incidence
 Main bronchus (including intermediate)    11
 Lobar bronchus                        29
 Segmental bronchus                     29
 Segmental area (i.e., peripheral tumor)     31
              E.  SUMMARY
   This chapter reviews toxicological studies
 of various types of particulate matter known
 to be present in ambient atmospheres. These
 studies are  primarily  concerned  with  the
 disciplinary  areas of  pathology, physiology,
 and carcinogenesis.  In  addition, the mecha-
 nisms of  the toxicological action of particu-
 late matter are discussed and considerations
 concerning mixtures  of irritant  gases and
 particulate matter  are given proper empha-
 sis.  To date, studies utilizing laboratory ani-
 mals have, in the main,  been concerned with
 levels of  particulate materials far in excess
 of ambient concentrations. Although direct
 extrapolations  from  the laboratory animal
 to man are impossible, animal experimenta-
 tion is useful and necessary for rapidly de-
 fining the toxicological mechanisms of  ac-
 tion and  for pinpointing the primary bio-
 logical systems affected by a specific particu-
 late material alone or in the presence of an
 irritant gas.  Findings obtained from animal
 experimentation  can  be tested under  com-
 munity conditions  with human populations
 via epidemiological studies.
   Particulate matter may exert a toxic effect
 via one or more of three mechanisms:
     1. The  particle  may  be  intrinsically
       toxic due  to  its inherent chemical
       and/or  physical  characteristics;
     2. The particle may interfere with one
       or more of the clearance mechanisms
       in the respiratory tract;
     3. The particle  may act as a carrier of
       an adsorbed  toxic substance.
 The last of these mechanisms can lead to a
 "potentiating"  effect in which particles con-
 taining an adsorbed toxic substance increase
the physiological response  to the  adsorbed
                                                                              141

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substance to  a level above that which one
would expect if the substance were present
in the  absence of the  particle.  Conversely,
prior exposure of an animal to  particulate
matter can sometimes afford a degree of pro-
tection  to  subsequent  exposure  to  irritant
gases.  Particle size and  dust load both con-
tribute  toward determining the  toxicity  of
any specific  chemical substances: reduction
in particle size generally increases toxicity,
while  even  an  "inert"  particle  may  elicit
toxic responses when present in high enough
concentrations.  Finally,  it  has been  clearly
demonstrated  that  a number of substances
(metal dusts, asbestos, polynuclear aromatic
hydrocarbons, etc.)  known to be carcinogenic
in  animals  are present  in polluted  atmos-
pheres.  When linked with  urban-rural dif-
ferences in  lung cancer  frequency revealed
from epidemiologic  investigations, this evi-
dence indicates that such  substances in urban
polluted atmospheres may be potential car-
cinogens for the  exposed human  population.

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53. Kotin, P.  and Wiseley,  D.  V.  "Production  of
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        144

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          Chapter 11
EPIDEMIOLOGICAL APPRAISAL OF
     PARTICIPATE MATTER

-------
                           Table  of Contents
                                                                     Page
A. INTRODUCTION                                                  148

B. APPLICATION OF EPIDEMIOLOGY TO AIR POLLUTION .         148
   1.  Indices                                               	     148
   2.  Cautions                             .          .  .      ....   148
C. INDICES OF HUMAN RESPONSE: THE EPIDEMIOLOGIC
   STUDIES                                       	     150
   1.  Acute Episodes           .                                .       150
      a. Mortality              .                         .              150
      b. Morbidity                                       .             154
   2.  Chronic (Long-Term) Air Pollution                               156
      a. Day-to-Day Variations in Mortality and Morbidity                156
      b. Geographical Variation in Mortality                      .  .     156
        1.  Studies Based on Available Data            	          156
        2.  Special Studies Involving the Collection of New Data       ...   158
      c. Geographic Variations in Morbidity—Special Studies           .   161
      d. Morbidity—Incapacity for Work                      	   164
   3.  Studies of Children        .              .  .                  .165
   4.  Studies of Pulmonary Function            .             ...    167
   5.  Studies of Panels of Bronchitic Patients     .             ...     168
D. SUMMARY                .             	    169

E. REFERENCES                             	    176
                             List of  Figures
Figure
11-1  Mortality Figures for the January 1956 and December 1957 Smog
      "Episodes" in London     .                ......   151
11-2  Mortality and Air Pollution in Greater London during the Winter of
      1958-1959                             	     152
11-3  Death Rates and Air Pollution Levels in Dublin, Ireland, for 1938-
      1949                     .            	   155
11-4  Average Annual Death Rate from all Causes            .     .       160
11-5  Average Annual Death Rate  from Asthma, Bronchitis, or Emphy-
      sema Indicated on the Death Certificate     .          .          .   160
11-6  Average Annual Death Rate from Gastric Cancer                 .   161
11-7  Age-Standardized Morbidity  Rate per 1,000 for Three Diseases in
      Japan                                   ..           	   162
11-8  Effect  on  Bronchitic Patients of High  Pollution Levels (January
      1954)                                 	   169


 146

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                              List  of Tables
Table                                                                   Page
11-1  Pollution Levels in Salford (seasonal daily averages)     	    159
11-2  Average Annual Death Rates Per 1,000 Population From All Causes
      According  to Economic and Particluate Levels, and Age:  White
      Males 50-69 Years of Age, Buffalo and Environs, 1959-1961     .  .    159
11-3  Average Annual Death Rates Per 100,000 Population from Chronic
      Respiratory Disease According to Economic and Particulate Levels,
      and  Age:  White  Males 50-69 Years, Buffalo and Environs,  1959-
      1961                            .            .               .160
11-4  Average Annual Death Rates  Per  100,000  Population for Gastric
      Cancer According to Economic and Particulate Levels: White Males
      50-69 Years of Age, Buffalo and Environs, 1959-1961           .  .    161
11-5  Response of Telephone Workers in the U.K. and the U.S.A.  to Air
      Pollution                                        	    163
11-6  Summary Table of Epidemiological Studies       	        171
                                                                          147

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                                      Chapter 11

         EPIDEMIOLOGICAL APPRAISAL  OF  PARTICIPATE MATTER
           A.  INTRODUCTION
  Health effects produced  by  atmospheric
particulate matter are discussed in this chap-
ter in terms of  epidemiologic studies.  Be-
cause particulate matter tends to occur in
the same kinds  of  polluted atmosphere as
sulfur oxides, few epidemiologic studies have
been able adequately to differentiate the ef-
fects of two pollutants.  It follows, therefore,
that the studies presented in this chapter are
frequently identical  with those  described in
the companion document,  Air Quality Cri-
teria for Sulfur Oxides.
  Epidemiologic  studies,  as distinguished
from  toxicologic  or experimental  studies,
analyze the effects of pollution from  ambi-
ent exposure on  groups of people living in
a community. Such  studies have the advan-
tage of  examining  illness where it occurs
naturally, rather than in a  laboratory,  but
carry the disadvantage  of not being able to
control  precisely all the factors of  possible
importance.  Nevertheless,  the  preparation
of air quality criteria must rest on epidemio-
logic studies because of  the very severe limi-
tations of toxicologic and industrial studies
for this  purpose. Other countries,  notably
the Netherlands  and Sweden,  have  based
their air quality  criteria solely on epidemio-
logic studies.
  In determining whether  or not an asso-
ciation is causal,  consideration must be given
to several  aspects of association  which in-
clude  strength, consistency, specificity, tem-
porality, biological gradient,  plausibility, co-
herence,  and analogy.1  A judgment of  the
value  of an epidemiologic study requires an
understanding of these aspects.  Many types
of epidemiologic  evidence suggest that  air
pollution may exert considerable influence on
health, as well as on the "satisfaction with
life," of major segments of the world popu-
lation.
  Several health  indices are described  in
Section  B-l;  certain   precautions  which
should be observed in the application of epi-
demiologic methods  to air quality  criteria
are suggested in Section B-2. The studies
themselves are listed in Section  C,  accord-
ing to the index employed.

 B.  APPLICATION OF  EPIDEMIOLOGY
     TO  AIR POLLUTION STUDIES

                1. Indices
  Various indices of health may be used for
correlation with air pollution  by the oxides
of sulfur. Among the possible indices are:
    1. mortality (greater than expected)
       (i)  deaths from all causes
       (ii)  deaths from specific  causes
       (iii)  deaths among the different age
            and sex groups
    2. morbidity
       (i)  incidence  of  disease—chronic
            bronchitis,  pulmonary  emphy-
            sema, diffuse interstitial pneu-
            monitis,  cancer of  respiratory
            tract, disease of  remote organ
             (e.g., gastrointestinal, ophthal-
            mic,  and  cardiovascular  sys-
            tems)
       (ii)  prevalence  of diseases—same
            examples as for "incidence"
       (iii)  prevalence of respiratory symp-
            toms  (e.g.,  changes  in quality
            and/or  quantity  of   sputum
            production)
       (iv)  exacerbation of  diseases—rhi-
            norrhea, asthma, tracheobron-
            chitis, and chronic illness, and
       148

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            enhancement of infection: pne-
            umonia, sinusitis,  otitis,  mas-
            toiditis
       (v)  changes in clinical conditions
             (e.g., bronchitic patients)
    3. changes  in  various  aspects  of lung
       function
       (i)  ventilatory function—decrease
            in  peak flow  rate, decrease in
            spirometric  volumes,  impair-
            ment  of  flow-volume  relation-
            ship, and increased airway re-
            sistance
       (ii)  blood/gas distribution—impair-
            ment of lung-gas distribution
       (iii) blood/gas   exchange—impair-
            ment  of  pulmonary blood-gas
            exchange
       (iv) increased work of breathing
  Definitions of the various disease states are
to be found in the glossary; most of the pul-
monary function methods have been  men-
tioned in Chapters 9 and 10.
  The manner of presentation of the state of
epidemiological  knowledge of  effects of par-
ticulate matter  in  the  ambient atmosphere
when accompanied  by the oxides of sulfur is
outlined in the Table of Contents.

               2.  Cautions
  In the first place, as  discussed in  Chapter
1, methods of measurement vary from coun-
try to country  and place  to  place. Results
from the high volume sampler and the results
from smoke stain  calibration are very dis-
similar. Also, coh values cannot be compared
with ju,g/m3.
  Secondly, particle size plays an important
part in the appropriateness of the measuring
technique as it  does in determining the site
and effectiveness of deposition in the respira-
tory tract.  (See Chapter 9.)  However, size
distribution of  particles has  nearly  always
been ignored in field studies.
  Thirdly, pollution and health indices are
not always measured  over the same time
periods. It is to be hoped that the pollution
levels cited bear some relation to those extant
during the  time when the chronic disease
states were developing. Further, acute effects
require frequent short-term pollution meas-
urements  to  enhance detection, while long-
term  chronic processes  may  be adequately
related to long-term sampling intervals. Air
pollution measurements  useful in studies of
acute health  effects are  becoming available;
a less satisfactory situation exists for the
long-term effects studied.
  In many instances the possible role of cig-
arette smoking has not been considered. It is
expected that  future  epidemiologic studies
involving adults will routinely collect data on
smoking habits of the  study group.  Other
factors  are significantly related to respira-
tory disease. These include occupational and
other past exposures; infections,  past  and
present; and allergy and heredity.
  Few or no epidemiologic studies have been
possible where the  pollution  challenge has
been  limited  to particulate matter,  unaccom-
panied by  significant amounts of other pol-
lutant substances.  Indeed, most of the availa-
ble conclusions link particulate levels with
those of concurrently measured  sulfur  di-
oxide; some  studies attempt statistical sep-
aration of  the culpability of one factor from
the other in the effects cited.
  In  seeking the possible effects on popula-
tions  resident in areas of differing air pollu-
tion, factors such as smoking, type and condi-
tions  of employment' ethnic group, and mobil-
ity in response to experienced  irritation or
disease  have  sometimes  been  considered.
There has, however, been a minimum of at-
tention paid  to the indoor or domestic envi-
ronments  and  their  potential  contribution.
Measurement of such indoor exposures might
be difficult, but omission of the information
could well modify the appraisal of the im-
portance of particulate pollution.
  Toxicologic studies indicate a specific po-
tential of some particulate materials to pro-
duce  human responses.  The levels used in
toxicologic studies are far higher than those
found in the communities in  the epidemio-
logic  studies under review. Thus the actual
responsibility  of  "particulate  matter" for
the community responses is uncertain,  and
it is sometimes necessary to invoke addition-
al  concepts;  for example, the  idea of syn-
ergism with other  known or unkown ambient
pollutants, or the idea that particulate matter
is but an index of availability of some other
                                                                              149

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substance (s) which are fully responsible for
the effects  reported.
  Over a  short  period  of time, mortality
fluctuates  considerably,  and  only a  syste-
matic, long-term  approach will allow a valid
determination of the real role of air pollution.
Cassell et al.2 have reviewed the problem of
detecting peaks  in mortality  and  relating
them to any single variable. The danger with
episodic studies is that short-term fluctuation
in the death rate,  when picked  to  coincide
with  an air  pollution  incident, may appear
to be causally related; in the long term, how-
ever,  numerous other unassociated peaks are
found in both the death rates and the air pol-
lution levels.
  Specific substances encountered as respira-
ble particles, and associated with disease en-
tities (beryllium, asbestos, arsenic, vanadi-
um, lead, airborne pathogens, etc.)  are not
assessed in this report. They deserve consid-
eration, however, as exemplars of the modes
of response of which the human is  capable,
and which  may delay or  confound the recog-
nition of the importance  of "particulate mat-
ter"  inhalation.  The demonstration of  the
importance of aerodynamic behavior rather
than  of mass or particle dimension for both
impingement  and  retention of  asbestos is
striking. Long-delayed  effects from relatively
brief community  dispersion exposures to as-
bestos and beryllium  are  significant (see
Chapter 10). Furthermore, penetration  of
"poorly cleared"  particles of asbestos  to re-
mote  body sites suggests  complex  body trans-
port mechanisms, differing organ or  tissue
sensitivities,  and the need for evaluation of
as yet untested relationships between disease
entities and respirable  offenders.  These mod-
els confer some sense of urgency to establish-
ing the relationships of  human disease and
dysfunction to air pollution by "general par-
ticulate matter."
  The concept of  "susceptible  population"
demands consideration. Human responses to
toxicants, and to community air pollution,
show wide  variations, which contribute in no
small way  to the difficulty in assessing in a
general  manner  the effects of  pollutants.
Since air quality  criteria must, unless other-
wise specified, consider "all" population rath-
er than  just major segments of it, studies
must consider especially the  impact of air
pollution on the "most sensitive" responders.
Many factors seem to enhance susceptibility
or sensitivity to air pollution. These include
being at the extremes of age (i.e., infants and
the very  old); having pre-existing chronic
respiratory disease (e.g., pulmonary emphy-
sema or  chronic  bronchitis);  having pre-
existing cardiovascular  disease  (functional
capacity not defined); regularly smoking cig-
arettes; or living in overcrowded or depressed
socioeconomic strata. Some of these factors
have been singled  out for  attention in the
references to  be cited, and the level of pol-
lutant said to have an "effect" may take cog-
nizance of such special sensitivity.
  The effects discussed are related insofar as
possible to specific pollution over specific time
intervals; it must be emphasized that lower
values by no means imply a "no effect" level
of the pollutants.

  C.  INDICES OF HUMAN RESPONSE:
     THE EPIDEMIOLOGIC STUDIES
            1.  Acute Episodes
a. Mortality
  In  conurbations,  such as  London,  New
York, Chicago, and Detroit, it has been pos-
sible to observe deviations from the moving
averages of deaths during  various seasons,
and to relate such deviations to the coincident
period levels of air pollutants.3
  In writing about the Meuse Valley episode
in 1936, Firket stated that if  there were a
similar  phenomenon in London, some 3,200
death might occur.*-5 Unfortunately, he was
quite accurate in his estimate since, in Decem-
ber 1952, the world's most disastrous smog
incident occurred in  London,  causing  about
4,000 excess deaths throughout the Greater
London area.  Marked increases were  noted
in both respiratory and cardiovascular deaths
(and  for  almost every  cause  except traffic
accidents; presumably the smog was too thick
for people to drive). Since some of the diseas-
es such  as lung cancer and tuberculosis were
obviously  existent  before the  pollution ep-
isode, much of the effect of the fog was clear-
ly to hasten the  death of people who were
already ill. Detailed investigations were made
of 1,280 post-mortem reports of persons who
       150

-------
had died before, during, or shortly after the
episode. No fatalities were found which could
not have been explained by previous respira-
tory or cardiovascular lesions. In this episode
as in others, the elderly and persons with pre-
existing pulmonary and cardiac disease were
most susceptible.
  A number of investigations have analyzed
and compared the various London episodes.
The report by Brasser et al.6 appears to cover
all  the  episodes  and to present  a detailed
analysis  of  each  of these episodes, pointing
out the importance of  the  duration of  the
maximum values. More recently, Joosting7
has examined the relationship between  the
duration of maximum values of sulfur dioxide
and smoke during air pollution episodes, as
well as the differential relationship between
sulfur dioxide and  smoke levels and the re-
sulting mortality.
  Gore and  Shaddick8 and Burgess and
Shaddick9 reviewed acute  "fog" episodes
which occurred in London in 1954,1955,1956
(January and Decmeber), and 1957 (Decem-
ber), in  terms of excess mortality above a
moving average, related to the mean of daily
readings at seven stations for smoke and S02.
Figure 11-1 shows mortality figures for the
January  1956 and  December 1957 episodes.
Somewhat differing  patterns  of onset  of
mortality rise, of age of population suffering
most heavily, of deaths related to  bronchitis
and to other respiratory diseases, and of total
deaths, were noted in these acute episodes.
                      JANUARY, 1956
                                                          DECEMBER. 1957
                200r
                                           ALLAGES
                                           70+YEARS
                                          0-69 YEARS
                      31   5  10  15  20 25
                                                         25  30  5 10  15
                      DEC. JAN.
                                                           NOV. DEC.
FIGURE 11-1. Mortality Figures for the January 1956 and December 1957 Smog "Episodes" in London.0 (The
  figure shows the increase in numbers of deaths during smog "episodes" (shaded periods), especially in the
  older age group.)

                                                                             151
                         347-335  P.O. 3  69-461   REV. REPRO

-------
Common to them, however, were elevations
in the mean daily levels of S02 and smoke,
measured at seven  different stations, from
two to four times the winter average levels;
"effects" were estimated at 2,000 /ig/m3 black
suspended  matter  together  with 0.4  ppm
(1,145 Atg/m3)  S02  (representing all acidic
gases). Deaths ascribed to bronchitis were
materially  affected,  but deaths due to other
causes also increased. Deaths appeared to
begin to increase before the onset of the ep-
isodes; during  the episodes, of course, they
increased substantially. Scott10 observed  a
similar relationship, for similar periods of
"fog," with "effective  pollutant" levels at
seven different stations in London  of 2,000
/ug/m3 for smoke and 0.4 ppm for S02. There
was a sharp impact on the elderly and the
greatest proportionate  rise,  for  cause of
death, in bronchitics.
  Martin  and  Bradleyll  correlated  daily
mortality (all  causes) and daily bronchitis
mortality with mean  daily black suspended
matter (see Figure 11-2) measured at seven
locations in London for the winter  of  1958-
1959, and also found a significant positive as-
t-
tr
O
z in
— LU
i!
|3
LU <
O
       80
       60
      40
       20-
      -20 -
      -40
      -60
      -80
     •v-:.  s
       • •.  -
            ••
 •!•* •
   ••• •
*.«*/
            CORRELATION COEFFICIENT r = 0.613

             i	I	I	I	I	I
        1.0   1.2
                  1.4
                       1.6   1.8
                                2.0
                                     2.2   2.4
                          sociation between mean daily sufur dioxide
                          levels and  deaths  (all causes). Bronchitis
                          deaths  showed a lower correlation with the
                          pollution level, and the authors suggest the
                          need for consideration of effects of air pol-
                          lution  on patients  with cardiovascular  di-
                          sease. In addition,  excess deaths have been
                          related to increases (on the day preceding
                          death)  of mean daily black suspended matter
                          by more  than 200 jug/m3,  and rises in mean
                          daily S02 of more than about 75 /ag/m3  (2.5
                          pphm). In a later paper,12 data are shown to
                          suggest an increase in mortality  from all
                          causes, and of respiratory and cardiac mor-
                          bidity,  associated with  levels of smoke about
                          1,000 /ttg/m3, and S02 concentrations of 715
                          ^g/m3  (25 pphm).  This "effect" is properly
                          related to abrupt rises in the concentration of
                          smoke and/or S02, with perhaps a continuum
                          of effects at lower  levels. Since these meas-
                          urements were obtained at a single point in
                          Central London, it should be presumed that a
                          relatively wide range of values around these
                          levels actually contributed to the mortality
                          statistics which were correlated. A reanalysis
                          by  Lawther13  of  these  mortality  studies
                                                     20
                                                     10-
                                              tc
                                              O
                                              HI
                                              Q
                                                    -20-
                                                                •••
                                                          CORRELATION COEFFICIENT r = 0.411
                                                      1.0   1.2    1.4
                                                                    1.6
                                                                         1.8   2.0  2.2  2.4
                               OF BLACK SUSPENDED MATTER CONCENTRATION)
FIGURE 11-2. Mortality and Air Pollution in Greater London during the Winter of 1958-1959." (The figure
      shows increased mortality due to "all causes" and to bronchitis during a period of high pollution.)
       152

-------
places the mortality "effect" at about 750 jug/
m3  for  smoke  and about  715  jug/m3  (0.25
ppm) for S02. Joosting states that the maxi-
mum sulfur  dioxide  concentration  above
which significant correlation  occurs  with
death and disease is 400 /*g/m3  to 500 //g/m3
(0.15 ppm to 0.19 pppm)* when there is a
high soot content.
  The Dutch report on sulfur dioxide,6 which
discusses in detail seven air pollution episodes
in London, states that in the December 1956
episode,  400 excess  deaths,  or 25 percent
above expected, were observed in Greater
London  at maximum 24-hour levels of 1,200
(Ug/m3 for smoke and 1,100  /tg/m3  (0.41
ppm) * for S02. The report also notes that in
January 1959, 200 excess deaths were observ-
ed in Greater London, or  10 percent above
expected  mortality,   at  a level  of  1,200
/j.g/m3 for smoke and 800 /xg/m3 (0.30 ppm) *
for S02. The episodes all took  place during
winter;  cold weather seems to have been an
important  feature of  London  air pollution
mortality.
  In Martin's review 12 in 1964  of daily mor-
tality in London during the winters of 1958-
1959  and 1959-1960, he concluded:  "From
the data it would be difficult to fix any thresh-
old value below which levels of air pollution
might be regarded as safe."  However,  his
review included data with  smoke concentra-
tions ranging upward from 500 yug/m3 and ac-
companied by sulfur  dioxide concentrations
of about 400 /*g/m3 (0.14 ppm)  and above.
  As a  result of  smoke control regulations,
the particle content of London air has steadi-
ly decreased since the  1950's, but the sulfur
dioxide  concentrations have  not decreased
proportionately. At the same measuring sites
as in 1952, sulfur dioxide was actually slight-
ly higher in the 1962 episode than in that of
1952, but  smoke levels  were  considerably
lower. Also, as Brasser et a/.6 have noted
there was only one day of maximum pollution
values in 1962 as contrasted with the 2 days
of maximum  pollution in December 1952.
Although the smoke levels  appear to be bet-
  *SO2 is converted from ppm to /ig/m* in the Dutch
report by using the equivalency 2,700 llg/TK'=\ ppm;
Scott apparently used 2,850 jug/m8=l  ppm; this re-
port uses 2,860 /ltg/ms= 1 ppm.
ter related to the amount of excess mortality,
other factors must be considered as possibly
also  reducing the number of  deaths. Since
1952, a great deal of publicity has been given
to the harmful effects of smog, and more sus-
ceptible individuals  have been  encouraged to
use masks and filters and stay indoors. In
addition, when episodes come close together,
a  large  number  of susceptible individuals
might not accumulate, since some are killed
off each time. An effect as large as that  seen
in the first incident would not, therefore, be
expected.
   The number of deaths in New York  City
was  reviewed for excess mortality in rela-
tion to the air pollution episode of November
1953, by  Greenburg et al.u  Excess deaths
were  related to elevations of concentrations
of sulfur dioxide  and  suspended  particles.
Average daily suspended particulate matter
measured in Central Park was in excess of
5.0 coh  units, while the S02 rose from the
New York City average ranges of 430 /*g/m3
to 570 jug/m3 (0.15 ppm to 0.20 ppm)  to a
maximum level of 2,460 /ig/m3 (0.86 ppm).
For  this episode, there was a "lag effect,"
and distribution of  excess deaths among all
age groups was noted. The number of deaths,
although not showing the marked rise seen
in some  of the London episodes, was above
average  for comparable periods  in other
years during and immediately after the in-
cident.  For  the November  15 to  24, 1953,
period,  the  average number of deaths per
day was 244, whereas during the three years
preceding and  following 1953, the average
was 224  deaths per day for the same calen-
dar period.
  A  later episode (1962) was  studied,15 But
Greenburg et al.  did  not discern an excess
mortality.  However,  McCarroll and Brad-
ley,16  reviewing episodes in New  York City
in November and December of  1962, January
and  February of 1963,  and February  and
March of 1964, compared 24-hour average
levels of various pollutants with New York
City mortality  figures,  employing  daily de-
viations from a 15-day moving average; the
measurements were  performed at  a  single
station in lower Manhattan and fluctuations
in the values at this station were known to
correlate well with  those at another station
                                                                            153

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6.5 miles away.  Excess deaths on December
1,  1962, followed a daily average S02 concen-
tration of 2,060 /*g/m3 (0.72 ppm) and smoke
shade in excess of 6 coh units, during a pe-
riod   of atmospheric  inversion and  low-
ground-wind speed.  The increased  death
rates were shared by the 45-to-64 age group,
as well as by the age group  over 65.  In a
later  episode (January 7, 1963) associated
with  an S02 concentration of 1,715 /xg/m3
(0.6 ppm)  and smoke shade at  6 coh units,
there was a peak of death rate apparently
superimposed upon an elevated  death rate
average due to the presence of influenza vi-
rus  in  the  community.  Two further epi-
sodes "•" also suggest the relationship  of
excess deaths to abrupt rises in both S02 and
suspended smoke at times of air stagnation.
   An example of the inherent danger of re-
lating mortality  peaks to air  pollution is
shown by Leonard et al.18 in the Dublin stud-
ies.  During the war  and post-war years of
1941  to 1947, peat was burned  as the main
fuel  rather  than  coal, and air pollution (as
measured by particle concentrations) was
markedly decreased.   Sulfur  dioxide  levels
varied in a manner similar to those  of sus-
pended particulate matter. The winter peaks
in death, however, were unaffected, and thus
do not seem to be related to air pollution.
When coal  again became  available in 1948,
the air pollution levels rose with no appar-
ent effect on the  death rate (see Figure 11-
3). Unfortunately, it is not possible to assess
the effects of changing medical practices and
the  advent  of  antibiotics for use  in treat-
ing respiratory diseases  on these data.
   In  Detroit19 a rise in infant mortality and
deaths  in cancer patients occurring over a
3-day period accompanied a  rise in the 3-
day  mean suspended particulate matter for
the  same period  above  200  /xg/m3  accom-
panied by an S02 maximum of 2,860  jug/m3
 (1.0  ppm)  (September 1952).   This  is not
believed to be related to the cold  temper-
atures which have  characterized the London
episodes.
   In Osaka, Japan, Watanabe20  reported on
excess deaths in a  December  1962 smog epi-
sode.  There were  60 excess  deaths  related
to mean  daily concentrations of suspended
matter greater  than 1,000 /ig/m3,  with ac-
companying  S02 greater  than 285
(0.1 ppm); the measurements were made at
a single station in the central commercial
area of the city.
  When  a  marked increase in air pollution
is associated with a sudden dramatic  rise in
the death rate or illness  rate  lasting for a
few days and both return to normal shortly
thereafter, a causal relationship is strongly
suggested.  Sudden changes in weather, how-
ever,  which may have caused the air pollu-
tion incident, must be considered as another
possible  cause of  the death  rate increase.
Over the years, a number of such acute epi-
sodes have been reported, and there seems
little  doubt that air pollution was the cause.
  The British studies presented in this sec-
tion suggest that excess mortality, a small
rise in the daily death rate, is detectable in
large populations  if  the  concentrations of
smoke and S02 rise abruptly to levels above
750 /xg/m3  and 715 /xg/m3 (about 0.25 ppm)
respectively; the same  effects are noted in
American cities for S02 concentrations above
1,700 tig/m3  (about 0.6 ppm) and a "smoke
shade" of 6 coh units. The major targets are
the aged population, patients with chronic ob-
structive pulmonary  disease,  and patients
with  cardiac  disease.  A  more distinct rise
in deaths is noted generally when particulate
matter  reaches  about 1,200 /xg/m3 for  one
day and sulfur dioxide levels exceed 1,000
/xg/m3 (about 0.35  ppm).   Daily concentra-
tions of suspended particulates  exceeding
2,000 /xg/m3 for one day in  conjunction with
levels of sulfur dioxide in excess of 1,500
/xg/m3 (~0.5 ppm) appear to be associated
with  an  increase in the death rate of 20 per-
cent or more over baseline levels.
b. Morbidity
  The acute episodes have resulted in sub-
stantial  increases in  illness.  Thus  a sur-
vey 21 of emergency  clinics at major New
York City  hospitals in November 1953 indi-
cated a  rise in visits for upper respiratory
infections and cardiac diseases in both chil-
dren and adults in all of the four hospitals
studied.  "Smoke shade" was close to 3 coh
units, and  sulfur dioxide concentrations  had
not yet exceeded 715 /xg/m3  (0.25 ppm) when
hospital admissions clearly rose.14
  Again, the number  of  emergency clinic
       154

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visits for bronchitis and  asthma  at seven
large New York City hospitals was examined
during the Thanksgiving 1966 air pollution
episode.22 There was a  rise in the number
of such  visits on the third day of the  epi-
sode,  among patients  age 45  and  over, at
three of the seven hospitals investigated.  Un-
fortunately, the  Thanksgiving holiday great-
ly complicated evaluation of the emergency
clinic visits  over the  holiday period.17
  In the investigation of the London episode
of December 1952, information  on illness
was collected from as many sources as pos-
sible  including sickness  claims, applications
for hospital  admission,  pneumonia notifica-
tions  and records of physicians. The analy-
sis  demonstrated a real and  important  in-
crease in morbidity, though there was some
indication that  the increase in  illness  was
not as large proportionately as the increase
in deaths and the effects were not so sudden
in producing a marked rise in the early days
of the episode.  In a number of other severe
London  episodes the increase in morbidity
put a considerable strain on the health serv-
ices.
  These episodes reflect results which  fall
into Level IV of the World Health Organiza-
tion's  "guides  to  air  quality."23  These
"guides," equivalent in  usage to  our term
"criteria," cover sets of concentrations  and
exposure times  at which specified types of
effects are  noted or at which no  effect is
noted. Level IV  includes "concentrations and
exposure times at and above which there is
likely  to be acute illness or  death in  sus-
ceptible groups of the population."
  2.   Chronic (Long-Term) Air Pollution
  Kurland 24 has called  to our attention that
air pollution episodes represent, by defini-
tion, massive, overwhelming, and unusual ex-
posure, and thus the most significant patho-
logic  effects.  There is  an "iceberg" effect
in that such data represent the obvious, while
the greater  share of the problem remains
submerged.   We  are dealing with  an essen-
tial dose-response situation, the upper limits
of which are represented by these episodes.
a. Day-to-Day  Variations  in  Mortality  and
   Morbidity
  In a systematic approach to analyzing res-
piratory and cardiac morbidity daily in Lon-
don, Martin 12 examined deviations in  mor-
bidity from a 15-day moving average in Lon-
don  during the winters of 1958-1959 and
1959-1960.  Both smoke and  sulfur dioxide
concentrations  appear to  be  about equally
related to morbidity rates,  and a definite ex-
cess in morbidity seemed to exist as it did for
mortality,  though  there  was a  somewhat
greater degree of irregularity.
  An approach similar to Martin's, but limit-
ed to observations on mortality, was used by
McCarroll and Bradley16 in New York City.
Covering a 3-year period  (1962-1964) they
examined a number of peaks in New York
City mortality  associated  with periods  of
high air pollution. There are examples given
where  sulfur dioxide and  smoke shade ap-
pear to be related to mortality.  The authors
present other episodes, however,  where the
relationship to  air pollution is not nearly as
clear, although  the death  rate  fluctuates to
even higher peaks. Reference to this analy-
sis  has  already been made in our discussion
of  the  data on episodes  in Section  B.I.
  McCarroll  et  al.22  studied  residents of a
New York City housing project, using week-
ly questionnaires.  Exact  levels of air pol-
lutants  which could  be  used for establish-
ment of air quality criteria were not given;
however, the data indicate that sulfur diox-
ide rather than  particulate matter was asso-
ciated  with  eye  irritation.  Symptoms  of
cough were also shown to be related  to air
pollution but were not well differentiated be-
tween  association  with particles and sulfur
dioxide.  The particular time-series analysis
used with these data is not well known, and
the biases inherent in its use have not been
fully determined.

b. Geographical Variations in  Mortality
  1. Studies  Based  on Available  Data.—
Mortality and morbidity statistics each have
advantages as  well  as  disadvantages.  Rec-
ords of illness should be more fruitful in de-
fining  subtle effects, since illness precedes
death and since all illness does  not  result
in death.  Mortality  statistics are collected
in every country and are available for quick
tabulation.  Unfortunately,  the  quality  of
mortality statistics varies.  One of the prob-
       156

-------
lems is that with the present system of tabu-
lating mortality data, a single cause of death
must be  selected  and  coded, even though
more than one cause may be involved in the
death. The single  cause of death designated
(e.g., specific  chronic  respiratory disease)
depends largely on the judgment of the at-
tending physician  and has little, if any, rela-
tion to epidemiologic use. While contributing
causes of  death appear on the death cer-
tificate, they are  not reflected in  summary
tabulations. The coding of  only the "under-
lying" cause of death minimizes the impor-
tance of such diseases as emphysema which
often appear on the death certificate as con-
tributory  or associated  causes of death.25
  Almost  all studies  of the effects of long-
term  exposure on death rates compare the
rate in one area with that in another. Mor-
tality as well as morbidity studies  are ham-
pered by  the possibility of differences other
than air pollution existing between the areas,
such as social class, occupation, age, and sex
composition of the population, and cigarette
smoking.  Assuming  that almost all deaths
are recorded and  tabulated,  comparison  of
total  mortality rates (i.e.,  deaths from all
causes) obviates the bias of diagnostic selec-
tion, but does not lessen the chances of other
associated factors  having caused the differ-
ence.
  Buck and Brown 26 reported in  1964 the
relation of standardized mortality ratios for
the 5-year  period  1955-1959 to four vari-
ables:  daily smoke and S02  concentrations
for March 1962 (presumed representative of
the study period),  population density in 1961,
and a social index of 1951.  The studies in-
volved populations in 214 areas of the United
Kingdom  (19  London  boroughs, 49 county
boroughs,  70  boroughs, 61  urban  districts,
and 15 rural districts).
  Statistical studies indicate that bronchitis
mortality  had a significant  positive associa-
tion with  both the smoke and the S02 con-
centrations  encountered in  these residential
areas, and also with social index. The stand-
ardized mortality rates  for lung cancer were
not, in general, significantly associated with
smoke or  S02 concentrations in the residen-
tial areas. Examination of  the tables  given
by  Buck and  Brown suggests that the ex-
cess of  bronchitis mortality occurred  for
classes of area where the average daily smoke
and S02 concentrations both exceeded  200
fi.g/m3.  Although  smoking  habits  were re-
viewed  and were  apparently  uniform from
area to area,  occupational and domestic in-
door environmental exposures were not con-
sidered.  The  pollutant values selected  for
the correlations do not cover  the same time
period as the mortality figures.
  A series  of papers by Stocks  et  al.,27-31
related  atmospheric pollution in urban and
rural localities with  mortality due to lung
cancer,  bronchitis, and pneumonia.  Stand-
ardized mortality  ratios apparently refer to
the period 1950 to 1953 for bronchitis and
pneumonia and to the  period 1950 to 1954
for lung cancer. Lung cancer mortality was
found to be strongly correlated with smoke
density in the atmosphere  for 26 areas of
northern England  and Wales, for 45 districts
of  Lancaster   and Yorkshire, and for  30
county boroughs.  (Similar  but weaker cor-
relations were observed within Greater Lon-
don.) Further, social differences in the popu-
lations concerned only partially  explain this
correlation.  Bronchitis and pneumonia  for
males and bronchitis for females  similarly
showed strong correlations  with smoke den-
sity in the atmosphere.  Cancers of  the stom-
ach  and intestine  in  the  county  boroughs
were also related significantly to smoke con-
centrations, and other relationships are de-
scribed  for various areas  of the country. It
is, however, difficult to extract specific quan-
titative "effect" levels for smoke or the other
pollutants studied. Papers 30> 31 describe the
statistical elimination applied  to develop sig-
nificant correlations of  spectographic analy-
ses of 13 trace elements with mortality rates.
Reanalysis of  the  data by  Anderson 32 con-
firmed the importance of  smoke  levels,  as
well as  social  and  population parameters, to
mortality from lung cancer;  vanadium is also
identified as an important independent con-
tributor  to lung cancer, female  cancer, and
pneumonia mortalities.
  In summary, the results  of this analysis
of long-term mortality indicate effects which
would coincide with Level III of the World
Health  Organization's "guides to  air qual-
ity." 23 Level III is defined as "concentrations
                                                                              157

-------
and exposure times at and above which there
is likely to be impairment of vital physiologic
functions or changes that may lead to chronic
diseases or shortening of life."
  2. Special Studies Involving the Collection
of New  Data.—In 1964, also, Wicken and
Buck 33 reported on a study of bronchitis and
lung cancer mortality in six areas of North-
east England, one in Eston, another in Stock-
ton and four in rural  districts. The deaths
covered the period 1952 to 1962. The survey
of decedents with cause of death from bron-
chitis or lung cancer was matched  against
the survey of decedents with cause of death
from  nonrespiratory disease controlled  for
age and sex;  the basis for the  diagnostic
classifications was not stated in the report.
Personal interviews were  carried out with
next of kin.  Personal interviews of a ran-
dom sample  of households were also con-
ducted to obtain sex, age, smoking habits and
occupation of the population at risk, the  liv-
ing population.  The survey of decedents was
carried out between January  and  October
1963; the survey of the living population was
carried out between  December  1963 and
March 1964.  Smoke and sulfur dioxide con-
centrations were measured in the  Eston ur-
ban district. One year's aerometric data was
obtained.  The  study was excellent in prin-
ciple  though, unfortunately, sulfur  dioxide
and particulate values  were available only
for the Eston urban district.
  Eston, itself,  as a sub-study, was subdi-
vided  into North Eston and South Eston.
North Eston contains or lies near heavy in-
dustrial  plants, whereas South Eston is  a
residential area.  During  the period May
1963  to  April  1964, mean  weekly observa-
tions  of  the sulfur  dioxide and smoke con-
centrations were carried out in two  sites in
North Eston and one station in South Eston.
Smoke values were 160 /tg/m3 and 80 /ag/m3
for North and South Eston respectively. The
sulfur dioxide value in North Eston on  the
yearly average was 115 /ig/m3 (0.040 ppm)
and for South Eston it was 74 yug/m3 (0.026
ppm). The deaths studied occurred between
1952 and 1962.  Adjustments were made for
differences in age composition, smoking hab-
its, and social class, and these were insuffi-
cient to explain the differences in lung can-
cer and bronchitis mortality rates between
the two localities.  Occupational exposure to
pollution was then taken into account in the
analysis.  The conclusion was that there is
an  association between  the degree of air
pollution and  the  incidence of  lung cancer
and bronchitis mortality in the two areas of
the Eston urban district. Though both sul-
fur dioxide and smoke  values  and  concen-
trations are furnished in the report and the
effects apparently cannot be separated, Bras-
ser et al.s  apparently have used the sulfur
dioxide  concentration  as the more relevant
measure of this study.
  The community of Salford  was classified
into three pollution areas by Burn and Pem-
berton,34 according to Table 11-1.  Five sam-
pling stations in  the area were  employed.
Despite the closeness of the ranges of values,
a high rate of bronchitis mortality, of  lung
cancer  mortality,  and of deaths from  all
causes,  was observed in  the high, compared
to the lower pollution wards. It appears (see
Section  C-4) that there was also an increased
rate of bronchitis  morbidity  in the highly
polluted wards.
  Winkelstein et al.35~31 analyzed pollution
effects in a group of studies  made in the
Buffalo, New  York, area.  In July of 1961,
21 air sampling stations were set up in and
around  the city of Buffalo, and daily values
for suspended particulates, dustfall, and ox-
ides of sulfur were taken until June of 1963.
Suspended particulate levels  were used  as
the index of air pollution.  On  the basis of
the measurements, the  study area was  di-
vided into four  contiguous areas "according
to their levels of air pollution.  Level 1 was
less than 80 /xg/m3 (2-yr. geometric mean);
level  2,  80 /*g/m3 to 100  /xg/m3; level 3,
100 jug/m3 to 135 (Ug/m3; and level 4, greater
than  135 ju.g/m3. Each area was also divided
into five economic groupings.  Mortality fig-
ures for the area were taken from the period
1959  to 1961,  with the 1960 census provid-
ing the  population basis.
  Annual  death rates per 100,000  popula-
tion for (1) all causes of death; (2) chronic
respiratory disease;  (3)   malignant  neo-
plasms  of  the bronchus, trachea, and lung;
and (4) gastric carcinoma were  related to
the four areas of air pollution intensity and
       158

-------
         Table 11-1.—POLLUTION LEVELS IN SALFORD (SEASONAL DAILY AVERAGES)*4
Pollution area
classification
High 	
Intermediate
Low

SO2 A
-------
dioxide  concentrations  and  soiling  indices
from 36 stations.  All codable  deaths regis-
tered between 1949 and 1960 (32,067)  were
then  distributed among census tracts rated
according  to high, moderate, and low pollu-
tion levels, and upper, middle, and lower eco-
nomic classes, and then further coded by age,
sex,  race, and underlying cause of death.
Standardized mortality ratios  (for total res-
piratory disease,  and  for pneumonia, influ-
enza, bronchitis,  emphysema, tuberculosis,
and  lung and bronchial  cancer)  were then
  50
                                                   140
   40
<
oc
UJ  30
Q
Z

<
iu  20
cc
UJ
  -10

           1234
                PARTICULATE LEVELS
                   (all economic levels)

FIGURE 11-4. Average Annual Death Rate from All
  Causes. (The graph shows the death rate per 1,000
  population for white males between 50 and 69 years
  of age for four levels of particulate matter, Buffalo
  and environs, 1959-1961.)
                                                HI
                                                I
                                                LU
                                                D
                                                D
                                                Z
                                                OC
                                                UJ
                                                    120
                                                    100
                                                    80
    60
    40
                                                     20
                  SiSSS-iS:

                                                                           •;•$:$:•:':•£•
                                                                                    '•ffffftt-S:
                                   mm®

                                                                                    :•:•:•:•:•:•:•:•:•*

                PARTICULATE LEVELS
                  (all economic levels)

FIGURE 11-5. Average Annual Death Rate from Asth-
  ma, Bronchitis, or Emphysema Indicated on the
  Death Certificate.  (The  graph shows the death
  rate  per 100,000 population for white males be-
  tween 50 and 69 years of age for four levels of par-
  ticulate matter, Buffalo and environs, 1959-1961.)
Table 11-3.—AVERAGE ANNUAL DEATH RATES PER 100,000 POPULATION FROM  CHRONIC  RESPI-
   RATORY DISEASE ACCORDING TO ECONOMIC AND PARTICULATE LEVELS, AND AGE:  WHITE
   MALES, 50-69 YEARS OF AGE, BUFFALO AND ENVIRONS, 1959-1961.
            Economic
              Level
                                                       Particulate Level
                                    1 (Low)
  a Rate based on less than five deaths.

       160
                           4 (High)
Total
1 (low)
2 . .
3 	
4 	
5 (high) 	
Total

. 	 .
64
—
	 35
. . 42
44

0*
75
65
47
63
62

126
96
51
114
0*
94

188
105
103 a

—
129

133
84
64
52
50
72


-------
  100
 z
 o
 o
 Q.
   50
 w

 <
 LLI
 Q
               PARTICULATE LEVELS
              (economic levels 2, 3, and 4)
                                     4
                                   (HIGH)
FIGURE 11-6. Average Annual Death Rate from Gas-
  tric  Cancer. (The graph shows the death rate per
  100,000 population for white males between 50 and
  69 years of age for four levels of particulate mat-
  ter,  Buffalo and environs, 1959-1961.)

related to the pollution indices obtained dur-
ing 1959.  The statistically significant mor-
tality increases were  those  for  all respira-
tory diseases related  to  sulfation and soil-
ing; lung and bronchial cancer mortality, and
bronchitis  and emphysema  mortality were
not clearly related.  "High" pollution in these
studies referred  to soiling at more than  1.1
coh units/1,000 linear feet and S02 concen-
trations of  more than about 30 ng/ms  (.01
ppm). A later paper40 derived from the same
study period, analyzed infant and fetal death
rates between 1955 and 1960.  For white in-
fant mortality,  significant regressions were
obtained for sulfation; dustfall (alone, or as
an interaction variable)  was  the most fre-
quently related variable.  In the study,  ac-
count was not taken of  smoking  habits of
the deceased; also, the "middle class" group
covered a relatively large segment of  the
decedents.
  It is  intresting to note that the associa-
tion  between  suspended  particulate  levels
and gastric cancer in the Buffalo study which
appeared  to be independent of economic sta-
tus  was  also  observed   in  the  Nashville
study.38

c.  Geographic   Variations  in  Morbidity—
   Special Studies
  It has  been postulated  that the study of
records  of   illness  rather  than  mortality
should be more fruitful in defining subtle
effects,  since morbidity  is  an earlier and
more sensitive index of deviation from nor-
mal health.  A much larger insult must pre-
sumably be  given to the body to cause  death
than to  cause  illness.   Routinely collected
morbidity data are, however,  not  generally
available. Data may occasionally be obtained
from group  insurance plans, hospital admis-
sion records, or existing school records. Since
such data are usually not collected in a uni-
form, precise manner, most morbidity stud-
ies  require   expensive and  time-consuming
field surveys with questionnaires  or actual
medical examinations of the subjects.
  Morbidity studies of adults involving long-
term exposures are frequently not as useful
Table  11-4.—AVERAGE  ANNUAL DEATH RATES  PER  100,000  POPULATION  FOR GASTRIC CANCER
   ACCORDING TO  ECONOMIC AND  PARTICULATE  LEVELS:  WHITE MALES, 50-69  YEARS  OF
   AGE,  BUFFALO  AND  ENVIRONS, 1959-1961.
Economic
Level

1 (low) 	
2 . 	
3 	
4 . . . : 	
5 (high)
Total 	
Particulate Level

1 (Low)
	 .
45(5)
	 —
15(3)
26(5)
	 26(13)

2
0(0)
41(12)
39(9)
38(9)
16(3)
34(33)

3
63(10)
48(10)
51(6)
63(5)
0(0)
53(31)

4 (High)
136(8)
84(8)
51(2)
—
— -
—

Total
77(18)
50(35)
44(17)
33(17)
20(8)
42(95)
  Figures in parentheses indicate numbers of deaths
                                                                               161

-------
as desired due to the presence of complicat-
ing factors such as occupation and smoking.
Accordingly, Anderson 30 has  recommended
that children and housewives be used to de-
termine  the health  effects of  air pollution.
  A study was conducted by Petrilli et al.41
in Genoa,  Italy, which followed Anderson's
recommendation.  The subjects were women
over 65 years  of age, nonsmokers who had
lived for a long period in the same area and
who had no industrial work experience. Eco-
nomic  and social conditions  in  the areas of
residence were thus considered as well  as
the levels of pollution in the areas of their
residence.  Pollutant measurements were car-
ried out between 1954 and 1964 in 19 differ-
ent areas, and morbidity indices were cal-
culated for 1961  and  1962 for this popula-
tion, which received free medical care from
the municipality and therefore was  under
continuous medical observation.  There was
a  significant  correlation between the fre-
quency of  bronchitis with mean annual sul-
fur dioxide levels (r = 0.98) and a nonsig-
nificant correlation  for mean  annual sus-
pended matter (r = 0.82) and  mean annual
dustfall (r = 0.66).
  Toyama,42 in a comprehensive study of air
pollution  and  its  health effects  in  Japan,
charts  the age-standardized morbidity rates
(per thousand) secured by interview survey
in 1961, and describes a gradient of respira-
tory disease morbidity from the highly in-
dustrialized (and presumably polluted) areas
to the rural areas of Japan.  Further, the
pulmonary  disease  morbidity  ratio  was
higher in the industrialized, polluted areas
than were the ratios for other disease group-
ings.  The gradient was not noted for cardio-
vascular diseases  nor  for gastrointestinal
diseases.  Unfortunately,  specific  pollutant
concentrations are not clearly  indicated to
accompany  these  data on morbidity.  The
age-standardized morbidity rates per thou-
sand for several cities  in  Japan are shown
in Figure 11-7.
   Holland et al.43 studied  the prevalence of
chronic respiratory disease  symptoms and
performance of  pulmonary function tests in
a  comparative study of  outdoor telephone
workmen in London, in rural England, and
on the east and west coasts of the United
States.  Types of occupational exposure, use
of cigarettes, and socioeconomic matching
were considered.  The annual mean concen-
tration of suspended particulate matter in
the British exposures was approximately 200
/tg/m3, and  approximately 120  /ig/m3 in the
American case. For sulfur dioxide, the mean
concentrations were: in London 300 /tg/m3
(—0.1  ppm),  in rural areas of England  60
jug/m3  (~0.02  ppm),  and  in  the  United
States  between  30 /ig/m3 and  120 /*g/m3
(~0.01 ppm and  ~0.04  ppm). Persistent
C RESPIRATORY
r

! I
V
\

1

1
J 	 .
II]
3 —~*
C III
0 10 20 30 (
CARDIOVASCULAR

ZH

I

I

I

zn
1
) 10 (
GASTROINTESTINAL



I

I

I

I
I I
) 10 20 3


KAWASAKI

YOKOHAMA

FUJI NO

KAINAN

DAITO

0
                                   RATE PER THOUSAND

FIGURE  11-7. Age-Standardized Morbidity Bate per 1,000 for Three Types of Diseases in Japan." (The
  mortality rate for respiratory diseases shows a clear correlation with pollution levels. There is no such clear
  correlation for cardiovascular or gastrointestinal disorders.)
       162

-------
cough, phlegm, and chest illness episodes and
increased sputum volume were  all signifi-
cantly more frequent in men (between the
ages of 50 and 59) in the London area than
in rural England;  and pulmonary function.
was poorer in relation to the levels of smoke
and sulfur dioxide. It  is possible, therefore,
that an increase in smoke concentration from
120 ju.g/m3 to 200 |U.g/m3 (with an equivalent
increase in  sulfur dioxide  level)  increases
the risk to older workers of deteriorated pul-
monary function and increased symptomatol-
ogy of chronic respiratory  disease.  Table
11-5  summarizes some  of  the  results ob-
tained.
  Holland and Reid 44  reviewed  respiratory
symptoms,  sputum  production,   and  lung
function levels in post office  employees both
in central London and in peripheral towns.
Over the age of 50, the London men had more
frequent and more severe respiratory symp-
toms,  produced more sputum, and had sig-
nificantly lower lung function tests. Socioeco-
                nomic factors were presumed the same, the
                occupational  exposures were homogenous,
                and corrections were applied for smoking.
                There were some physique differences in the
                rural  areas and allowances were made for
                these  in the statistical evaluation. Unfortu-
                nately, no quantitative air quality determina-
                tions accompanied these results. The authors
                nevertheless concluded that the  most likely
                cause of the difference in respiratory mor-
                bidity between the men working in Central
                London  and those  in the three  rural areas
                was related to the differences in the local air
                pollution.
                  In a group of Canadian veterans studied
                by Bates et al.,i5 a relationship  between air
                pollution and both bronchitis and pulmonary
                function measurements has  been reported.
                There are, unfortunately,  inadequate data
                on the levels  of smoke, sulfur dioxide, and
                other pollutants, in the four Canadian cities
                compared,  to derive specific relationships be-
                tween the  levels of these pollutants and the
Table 11-5.—RESPONSE OF TELEPHONE WORKERS IN THE U.K. AND U.S.A. TO AIR POLLUTION.'3
United Kingdom
London
Age
40-49
Number of men examined 	 - -
Persistent cough and phlegm
(percent)
Persistent cough and phlegm and
chest illness episode (percent) 	
FEVi.o (liters) mean values:
Non smokers
Cigarette smokers:
1-14 per day 	 ...
15-24 per day 	 	
25 or more per day
Sputum volume 2 cc. or more
(percent)

113
25.
10.
2.
2.
2.
2.
28.
7
6
8
6
6
5
9
Age
50-59
137
38.7
10.9
2.6
2.3
2.2
2.1
42.9
Age
40-49
267
24.
7.
3.
2.
2.
2.
22.
0
5
0
8
8
7
1
Rural
areas
Age
50-59
159
18.
5.
2.
2.
2.
2.
23.
9
0
8
6
5
5
5
United
Baltimore
Washington
Westchester
County
Age
40-49
396
22.2
6.8
3.5
3.4
3.2
3.2
7.1
Age
50-59
229
25.8
7.0
3.1
3.0
2.8
2.9
10.0
States

San Francisco
Los Angeles
Age
40-49
361
21.6
4.0
3.7
3.4
8.6
Age
50-59
119
24.4
7.6
3.3
2.8
14.3
Suspended particulate matter,
  24 hr (/.g/m«):
   Mean	
   Maximum	
Sulfur dioxide, 24 hr (>ig/m3),
  ppm in parentheses:
   Mean	
   Maximum	
   220
   4000
 290  (0.1)
3700  (1.3)
   200
   3000
 60  (0.02)
740  (0.26)
   120
   500
110  (0.04)
715  (0.25)
   120
   340
 30 (0.01)
170 (0.06)
                                                                              163

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prevalence or exacerbation of disease or the
deterioration of pulmonary function.  How-
ever,  there is an association in the "dirty"
cities  (Montreal and  Toronto) versus  the
"clean" cities  (Halifax  and Winnipeg)  of
increased  prevalence and severity  of  bron-
chitis, and poorer pulmonary function per-
formance.
  Anderson and Ferris 46> 47 completed a com-
parison of respiratory disease incidence and
air  pollution  in three residential  areas  of
Berlin, New  Hampshire, by prevalence sur-
vey.  Subjects who  were  nonsmokers and
those who were moderate smokers were spe-
cifically evaluated.   The different  levels  of
air  pollution  at one or more stations in each
area  were recorded  in relation to monthly
dustfall and to sulfur dioxide concentration.
Prevalence of  respiratory  disease  and pul-
monary  function  determinations  (FEVi.ft
and peak  expiratory flow rate) were made.
The mobility of the population, variations
of concentrations of pollutants within a given
area,  possible effects from  the area of occu-
pation,  and differences  in the in-home  en-
vironment, were considered as contributors
to the lack of consistent effect on the studied
parameters of  air  pollution.   In a  later
study "8 these authors compared this  "pol-
luted" town in New Hampshire with a con-
trol community in  British  Columbia and
again found an obscuring of the effects  of air
pollution on  respiratory  symptoms and pul-
monary function  performance,  suggesting
perhaps the overwhelming effect of cigarette
smoking in symptom production.  It should
be  noted,  however, that  the  pollution  levels
and the ranges were possibly too low or too
small to show a relationship.
  The Nashville air pollution  study49  re-
viewed total morbidity in relation to air pol-
lution. A wide matrix of sampling stations
was used  to  group the residence of individ-
uals into  areas of high, moderate, and low
pollution according  to geometric  mean  an-
nual measurements,  and the  morbidity data
were  secured by home interview.  Significant
"direct correlations" of total morbidity with
levels of pollution (measured by soiling in-
dex and 24-hour sulfur dioxide levels) were
observed for individuals  over 55 in the mid-
dle  socioeconomic class.  Cardiovascular dis-
eases were directly correlated with the aero-
metric parameters. There was  no statistical
evidence  of  increased  respiratory  disease
morbidity or morbidity of other organs and
systems.  The same  qualifications noted  for
the mortality data  in  this study apply  to
these data on morbidity.

d. Morbidity—Incapacity for Work
  Dohan50 reviewed the incidence  of res-
priatory  disease  producing absence  from
work in a population  of women employed
in several branches of an  electronics com-
pany in  the  eastern  part  of  the  United
States.  Pay scales were roughly equivalent
and presumptions were made, therefore, that
the socioeconomic status and smoking pat-
terns were uniform.  Air measurements were
made from areas near  the town of employ-
ment (for suspended particulate sulfates, ni-
trates, copper, zinc, vanadium, nickel, and
acetone-soluble organic  matter,  as well  as
total  suspended  particulate matter).  Ab-
sences for a respiratory illness in excess of 7
days were calculable from  company-employ-
ment and health-insurance records.   There
was  a significant  correlation of respiratory
disease absence frequency  with the concen-
tration of suspended • particulate  sulfates,
with 24-hour values measured  biweekly; al-
though the level of total suspended particu-
late  matter ranged  from 100 /tg/m3 to  190
jug/m3  in the various cities, a correlation was
not  demonstrated.   The implication of  the
significantly  correlated  datum "suspended
particulate sulfate" is not clear, as it might,
for example, be an index of the  community
fuel  consumption  or an index  of sulfur di-
oxide irritation.
  Burn and  Pemberton 3*  reviewed the in-
creased number of certificates of incapacity
issued to workers in Salford in relation to
smog episodes. When mean daily smoke pol-
lution, based  on  data  from five sampling
stations, exceeded  1,000 /xg/m3 for 2 consecu-
tive  days, the number  of  "bronchitis cer-
tificates"  issued exceeded the expected num-
ber by a factor of two, on four or five oc-
casions in 1958.
  During  1961-1962 a  study  of the inci-
dence of incapacity for work was conducted
by the British Ministry of Pensions and Na-
       164

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tional Insurance.51  The population  covered
was  representative of the working  popula-
tion  of  England and Wales. Rates  of sick-
ness absence for bronchitis, influenza, arth-
ritis and rheumatism  were related to  in-
dices of pollution.  There was a significant
correlation between bronchitis  incapacity in
middle-aged men (35-54)  and the  average
seasonal (October through March) levels of
smoke and  sulfur  dioxide  in high-density
residential districts,  based on 24-hour meas-
urements. For Greater London, there was a
significant correlation  between   bronchitis
incapacity and both  smoke and  sulfur di-
oxide for all age groups taken together, and
for men aged 35 to 54 and 55 to 59. It is
interesting that there was also more incapac-
ity from arthritis and rheumatism in areas
having heavy smoke pollution. Influenza in-
capacity was greater in those areas with
higher pollution  levels over Great  Britain
as a whole but not within the  Greater Lon-
don  conurbation, nor was there in this  lat-
ter area  any association between pollution
and  psychosis or psychoneurosis.  The low-
est  bronchitis inception rates  related  to
smoke levels  between  100  /ug/m3 and  200
/«g/m3 and to sulfur  dioxide concentrations
between 150 /*g/m3  and  250  /*g/m3 (0.053
ppm and 0.081  ppm).  The highest values
related  to particulate concentrations of  400
iug/m3 and 400 //.g/m3 (0.14  ppm)  sulfur di-
oxide.
   Verma et al.,->2 presented information  on
illness absences in relation  to  air pollution.
Illness data for the  employees (males and
females, ages 16 through 64) of a metro-
politan  New  York insurance company were
obtained through the records of the person-
nel department. They included medical his-
tory, X-ray  information, and laboratory re-
sults obtained by the medical department of
the company, and were classified by absences
due to respiratory illness and to nonrespira-
tory illness.  Mean  daily concentrations  of
air pollution  and meteorologic data were se-
cured from the monitoring system of metro-
politan  New  York: smoke shade,  sulfur di-
oxide, and carbon monoxide content were re-
ported.  The  data for the 2 years 1965 and
1966 were examined statistically and several
conclusions  were  reached.   There   was  a
strong time dependence, and yearly cyclical
behavior; when  this  factor  was  removed
there remained no  strong positive relation-
ship between respiratory absence and  the
pollution variables  studied. Respiratory ill-
ness absence rates were at  their highest
level when sulfur dioxide and smoke shade
levels were both  high on cool days; and a
lag effect for respiratory absences was  not
noted.
          3.   Studies of Children
  Comparisons of the prevalence of respira-
tory disease  in  areas of varying  pollution
levels have been  made to delineate the role
of air pollution  and specific  pollutants.  A
problem  common to all  the studies is  the
difficulty in guaranteeing that the areas  are
similar  (except for air pollution) in all fac-
tors that  might affect  the  prevalence  of
disease.
  Because studies on adults tend to be com-
plicated  by smoking habits, changes of oc-
cupations,  and changes  in address over a
period of years,  several  studies have been
directed  at effects of air pollution on school
children.  The advantages of  utilizing chil-
dren for research  on  the primary etiologic
effects of air pollution were  first noted by
Reid53 several years ago; Anderson32  has
most recently reaffirmed  this view.  A major
element of concern  is that deleterious effects
on  the  respiratory system of  very young
children  may have an effect  on the subse-
quent evolution of the chronic bronchitis syn-
drome in the adult population.
  The relationships of respiratory infections
to long-term residence in specific  localities
have  been studied  in England by Douglas
and  Waller.54  Levels of  air  pollution,  in
terms of domestic coal consumption records,
were used to classify four groups; the auth-
ors include an evaluation of the validity of
this method at the  end of their report.  The
histories of 3,866 children born during  the
first week of  March 1946 were followed until
1961, when the children were  15  years of
age. Social class composition of these chil-
dren did not differ significantly from area
to area.  Measured  concentrations for smoke
and for  S02 in  1962  and 1963 were com-
pared with the earlier prediction  of pollu-
tion intensity based on the coal consumption
                                                                             165

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data, and indicated an overlap for the greater
London area of low and moderate groupings;
for other areas,  the predicted  gradient of
concentrations was affirmed.  Because of the
age of the subjects, smoking was apparently
not considered  in this evaluation. In 1965,
19 percent of the boys and 5 percent of the
girls, aged  11  to 13, smoked  at  least one
cigarette a week regularly.55
  In the Douglas and Waller study, the gen-
eration of pollutants in the indoor home en-
vironment  (e.g.,  by  heating and cooking)
was  not considered.  Interviews were  con-
ducted with the mothers when the children
were 2 and 4 years of age; information was
obtained about  upper and lower respiratory
illness and recorded  hospital admissions for
these and  other  causes.  Data about colds,
coughs, and hospital admissions were also
gathered by school  doctors at  medical ex-
aminations when the children were 6, 7, 11
and  15 years of  age.  Between the  ages of
6V& and 10i/£, special records for causes of
school absence exceeding one week were re-
viewed  with the  mothers.  A total of 3,131
families remained in the same pollution area
throughout the first 11 years of this study.
The conclusions of the study were that upper
respiratory tract  infections were not related
to the amount of air pollution, but that lower
respiratory tract  infections were. Frequency
and  severity of lower respiratory tract in-
fections increased with the  amount of air
pollution exposure, affecting both boys and
girls, and with no differences detectable be-
tween  children  of middle class  and working
class  families.  This  association was found
at each of the  examination ages, including
age 15. At age 15, persistence of rales and
rhonchi (chest noise), possibly the prodrome
of adult chronic respiratory  disease,  was
some tenfold less in  the very low pollution
area, and a factor of two less in the low pol-
lution  area than  that in the high pollution
area. If the 1962-1963 measured concentra-
tions for smoke and S02 can truly be extrap-
olated to the 15-year respiratory illness sur-
vey,  then these British school children ex-
perienced increased  frequency  and severity
of lower respiratory  diseases in association
with  annual mean  smoke  concentrations
ranging above 130 /ig/m3 and SO2 above 130
//.g/m3 (0.046 ppm).
  The  lower respiratory tract  findings of
Douglas  and Waller were  confirmed in a
study by Lunn et a£.56 The  patterns of res-
piratory illness in school children of the age
group 5  to 6 have  been studied with ref-
erence to residence in four areas of Sheffield.
Mean daily smoke levels measured in each
of four  areas ranged from  97 jug/m3  in the
"low" area to 301 /ig/m3 in the "high" area;
S02  concentrations  were respectively 123
/ig/m3  (0.043 ppm)  and 275 ^g/m3  (0.096
ppm) in the two  areas, during 1963-1964.
Somewhat  lower pollution levels were noted
the following year, although the gradient be-
tween the  districts  was preserved.   Ques-
tionnaire to the parents, physical examina-
tion, observation for the presence  of nasal
discharge, examination of the eardrums, and
recording of both the forced expiratory vol-
ume of  0.75 seconds  (FEV0.75)   and the
forced vital capacity (FVC), were completed
during each  of the summer terms  of 1963,
1964, and  1965. Several socioeconomic fac-
tors were compared for the various districts;
smoking  was appropriately  disregarded for
this age group; internal home environments,
or differences in home heating systems, were
not  reported.  The  authors conclude that
there is an association with the levels of at-
mospheric  pollution  and chronic upper res-
piratory  infections  (as indicated by muco-
purulent nasal discharge, history  of three
or more colds  yearly, or scarred  or perfo-
rated eardrum). Further, lower respiratory
tract illness  (measured  by history of fre-
quent chest colds  or episodes of bronchitis
or  pneumonia) was similarly associated.
Functional changes,  in the form of reduced
FEVo.75 ratios  emerged  where there  was a
past history  of pneumonia or bronchitis, of
persistent  or frequent  cough,  or  of colds
going to the chest.   There  appears,  there-
fore, to be a persistence of  respiratory dys-
function, even  in the absence of high-pollu-
tion  extant  at the  time  of the  function
testing.  The lowest  "effect" level for smoke
and  S02 is  not clearly indicated by this
study, but  the increased  association of "res-
piratory  infections" in  school  children can
be detected for areas whose mean daily fig-
       166

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 ures exceed about 100 /4T/m3 for smoke and
 120 jug/m3 (0.042 ppm) for S02.
   The exacerbation of acute  respiratory ill-
 ness of school children in Ferrara, Italy, has
 been studied by Paccagnella et ol57  Air pol-
 lution   measurements  from  1959  through
 1964  permitted definition of  high, medium,
 and low zones of pollution.  School  children
 in the age range 7 to 12 had  daily examina-
 tions, and the date  of onset of acute respira-
 tory disease was recorded. Although climatic
 conditions were related to changes in pollut-
 ant levels, the onset of acute respiratory dis-
 ease in the children was not correlated sig-
 nificantly with changing air pollution values,
 except  in the poorest socioeconomic  area.
 The pollutant values for this community are,
 however,  lower than those encountered in
 the British studies previously discussed (20
 /xg/m3  to  45 jug/m3  annual mean).  In fact,
 these are levels which are lower than many
 rural values in the United States.
   Toyama42 studied two  groups of school
 children,  10 to 11  years old, in Kawasaki,
 Japan.  Sulfation rates at the school in the
 more polluted area varied from 0.5 to  1.9
 and averaged 0.9 mg/100cm2-day Pb02; no
 sulfation  rates were given for the school in
 the area  of lower  pollution.  Dustfall  was
 considerably less in  the area of lower pol-
 lution   (ranging from about 5  tons/km2-
 mo. to 15 tons/km2-mo.) * than in the more
 polluted area  (ranging from about 15 tons/
 km2-mo. to  70 tons/km2-mo.). The children
 from  the  more polluted area had a higher
 frequency of nonproductive cough, irritation
 of the upper respiratory tract, and increased
 mucus secretion. Whether the effect was due
 to oxides of sulfur or particulate matter can-
 not be determined from this study.
  A study by Manzhenko 5S of upper respira-
 tory tract conditions in  school children in
 Irkutsk is difficult  to relate to the Sheffield
 study.  However, the higher incidence of res-
 piratory tract  conditions and the undefined
 abnormal  X-ray findings  in these children's
 lungs are disturbing evidence of the possi-
 bility of an association between serious res-
 piratory disease and residence in a polluted
 community.

    4.   Studies  of Pulmonary Function
   Holland et al.*s report decreased perform-
 ance of the FEVi.o test in London and Brit-
 ish  rural  outside telephone workers  com-
 pared  with  their American  counterparts.
 For both groups  the FEV was further de-
 creased  in relation  to  smoking  intensity.
 FEV differences within the United Kingdom
 workers  (i.e.,  London versus rural)  could
 also be related to the sulfur dioxide concen-
 trations accompanying the  particulate lev-
 els.  A more detailed discussion of the study
 appears in Section C-4.
   Toyama 42 reported measurements of peak
 flow rate and total vital capacity perform-
 ance in Japanese  school children in areas of
 differing  air  pollution, measured monthly;
 fluctuations were  observed in the mean peak
 flow rates of children attending schools and
 living  in  polluted industrial areas; and the
 variations were  smaller  for  children in
 clearer areas.  Total vital  capacity was not
 significantly different between pupils of the
 various schools.  There was a  substantial
 difference  in  peak  flow rates between the
 two school districts at times of highest pol-
 lution.  When pollution values were lowest,
 the differences were less.  The lowest values
 related to  dustfall  measurements of  60
 tons/km2-mo.* and daily sulfur dioxide levels
 equivalent to 20 /xg/cm2 (lead candle meas-
 urement) .
   In Osaka, Watanabe20  studied  the  peak
 flow rate and vital capacity performances by
 the children of schools enduring differing air
 pollutant  concentrations.  It was noted  that
 individual  peak  flow rates  were more mark-
 edly decreased in the winter months (Sep-
 tember to December,  1963) for the school
 in  the  highly  polluted area than for the
 school  in the low pollution area. Daily mean
 concentrations  of both dustfall and sulfur
 dioxide concentrations were twice as great
 in the polluted area as in the unpolluted area.
   In a comparison by Prindle et a/.59 of pul-
  *In  the United  States, dustfall is measured in
tons/mi2-mo.
  *In  the United States, dustfall is measured in
tons/mi2-mo.
                                                                              167

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monary function and  other parameters in
two Pennsylvania communities with widely
different air pollution levels, average airway
resistance  and  specific  airway  resistance
were measured in persons 30 years of age
and older.  These measurements were  per-
formed at several stations in each of the com-
munities and  indicated differences  between
the high-pollution and  low-pollution commu-
nities  which were  probably related to the
sixfold greater dustfall.  However,  smoking
and occupation were not accounted for.
  In the paper by  Lunn  et al.,5S  Sheffield
school  children were shown to have reduced
FEVo.75 and FVC ratios in the area of high-
est pollution.  The measurements were made
during the  summer, when pollution levels
were low and apparent incidence  of acute
respiratory  infection was  diminished,  sug-
gesting, in contrast  to the Japanese studies
referred to  above,  that  there may be  per-
sistence of the respiratory function deterio-
ration  in relation to residence in the area of
high pollution; mean  daily averages meas-
ured at a single station were:  smoke, 300
Mg/m3; SO2, 275 /*g/m3 (0.096 ppm).
  The  studies relating morbidity and deteri-
oration in pulmonary function to particulate
levels cover effects which are also  included
in Level III of the World Health Organiza-
tion's "guides to air quality."23
5.  Studies  of Panels of Bronchitis Patients
  Lawther"°  related  several  episodes of
acute urban  pollution  to worsening of  con-
dition in a group of  bronchitic patients, well
studied in a registry  at St. Bartholomew's
hospital. Changes in their symptomatology
were  recorded in a daily diary and acute
worsening  in  significant  numbers of the
group  was associated with daily rises in air
pollution above 300 /xg/m3 of smoke and 600
jug/m3  (0.21 ppm) of sulfur dioxide. Figure
11-8 shows  graphically the effects  observed
on 29  bronchitic patients of high  pollution
levels in January 1954.
  Angel et al.S2 reviewed the occurrence of
new respiratory symptoms in men,  working
in factories  and in offices, most  of whom
had  prior  evidence of  chronic bronchitis.
The study group of 85 men observed through
the winter of  1962-1963 was selected from a
group of 1,000 men, age 30 through 59, with-
out apparent classification of either smoking
patterns or possible occupational or residen-
tial exposure differences.  Increased sputum
production, deterioration of pulmonary func-
tion performance  (FEVi.o), and  the more
frequent occurrence of  respiratory  symp-
toms classified as "upper"  (coryza, influenza,
and acute respiratory disease), and "lower"
(chest  colds, bronchitis, wheezy attacks,
pneumonia)  were all  associated  with  in-
creases  in  both smoke and sulfur dioxide
concentrations.  There  was  frequently diffi-
culty  in defining an exacerbation of disease
in  those individuals  already  experiencing
chronic  bronchitis.  During this period,  ill-
ness peaks  (attack rate) may have occurred
with weekly  mean concentrations  of  smoke
exceeding 400 /*g/m3 and of sulfur dioxide
exceeding 460  /ig/m3  (0.16 ppm); weekly
mean concentrations were calculated using
the highest daily mean occurring each week
at each of 13 locations in the area.
  BiersteckerS3  surveyed  male   municipal
employees  in Rotterdam  for  symptoms of
bronchitis and for peak flow meter perform-
ance,  and  reviewed  years  of  residence in
Rotterdam  versus years of residence in a
nonurban environment  as well as smoking
habits.   The  individuals  with  bronchitis
symptoms  were matched with individuals
without such symptoms but with similar age
and background. Significant differences  re-
lated  to heavy  cigarette smoking, but  no
reliable  statistical indication of an effect of
urban or nonurban residence in the produc-
tion of symptoms was detectable.  Since par-
ticulate  levels in Rotterdam are very low,  the
range of difference between particulate levels
in Rotterdam and the nonurban environment
may have been close to minimal.
  Fletcher et al.6i followed 1,136 working
men aged 30 to 59 in West London by sur-
veys at  6-month intervals.  The surveys  in-
cluded collection and measurement of  morn-
ing sputum volume, FEV,  and respiratory
symptom  questionnaires.   While  expected
patterns of decline in lung function with age
occurred and this was the most rapid in
cigarette smokers  with low lung fuction to
start  with, an unexpected finding  was a  de-
crease in sputum volume in men  with con-
stant smoking  habits.  This was  most con-
       168

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                           16
17
18
             MEAN
            TEMP°F
            SMOKE
            mg/m3
                                                                       RH
                                                                 60  PERCENT
                                                                        so2
                                                                        ppm
             NUMBER
               OF
            PATIENTS
             WORSE
             BETTER
                                       JANUARY 1954

FIGURE 11-8.  Effect on Bronchitic Patients of High Pollution Levels (January 1954).6061 (The figure repre-
  sents the effect on bronchi tic patients of increased pollution levels; patients stated whether they regarded
  their condition as "worse" or better".)
sistent in the winter samples,  but showed a
significant trend in samples taken together
as well as in the  winter samples.  (Trend
data are  based on 825 men who  attended
at least  nine periodic  examinations.)  The
authors felt  this was possibly due to a de-
cline in air pollution in London.  They  pre-
sented data on trends in S02 and black  sus-
pended matter which indicated that there is
a consistent  downward  trend in particulate
pollution  (highly  significant)  but  a  less
steady decline in S02.
  This unique set  of data  could  mean  that
with a decrease of smoke pollution (yearly
mean) from  140 jug/m3 to 60 /tg/m3, there is
an associated decrease  in mean sputum  vol-
ume during  the first  morning  hour from
about 1.5 ml to about 0.75 ml. A contribu-
tion of the decrease in S02 is less  likely than
             that of  the  decrease  in  smoke.  Possible
             changes  in  cigarette  tars,  in  methods of
             smoking  and in techniques for collecting a
             sample, or other factors,  could  have influ-
             enced this result.
                1st hour sputum volume—In men of
                      constant smoking habits
                           1961  1962  1963  1964  1965  1966
             Summer       1.65  0.83 0.93 0.93  0.83  0.72
             Winter       1.38  1.27 1.20 1,13  0.70    .
                          D.  SUMMARY
               This chapter reviews epidemiologic studies
             of the relationship  between  pollutant  con-
             centrations and their  effects on  health. In-
             dices varying from disturbance of lung func-
             tion to death are considered.  Concentration
             measurements  of pollutants are sometimes
             available for the period during which the
                                                                               169

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indicators were under review,  and in these
cases it is possible to state pollutant levels
at which an effect is noted.  However, such
values cannot be taken to mean that effects
will  not be noted at lower  concentrations.
Most  studies  involving  long-term  effects
using a geographic area comparison will use
the  cleanest  area  as  the  "control" area
against which mortality and morbidity dif-
ferentials are to be found. This necessarily
assumes that this "cleanest" area itself does
not have any effects from its level of pollu-
tion.  Conversely, some  studies have com-
pared areas with very low particulate load-
ing or with  very limited ranges  of differ-
ences.  It is not possible to demonstrate any
relationship under  conditions  of  minimum
values or minimal  differences.  Table 11-6
summarizes the  epidemiologic  studies  re-
viewed according to the several indices.
  From the material reviewed  in this chap-
ter, a selection has  been made of data from
those studies which furnish  the best quan-
titative information that we have available
at the present time.  Levels are given in the
measurement  system used  in  the original
observations,  since  conversion  from  one
method to another is not recommended. At-
tention should be given to the difference be-
tween  British "smoke"  and  American "sus-
pended particulate" measurements.  Both are
given in micrograms per cubic meter of air,
but they are not identical. Limited data in-
dicate that the  American  values may be
higher  in  the same situation.  In  making
use of  these  data, attention must  also be
given to the averaging time  which was em-
ployed in  the  original observation.  Long-
term averages are, of necessity, considerably
lower than selected high daily means in the
same locations.
  British studies of acute  episodes of  in-
creased pollution show excess deaths occur-
ring at smoke levels from 750 /ug/m3 to 2,000
fig/m3.  High S03 levels are,  of course, con-
currently present.  The excesses of mortal-
ity are always accompanied by a very large
increase in illness,  mainly exacerbations of
chronic conditions.  Similar  but  less spec-
tacular episodes in New York City  have been
associated  with smoke shade levels of 5-6
coh units.
  Lawther, in reviewing a long series of ob-
servations  on the  condition  of bronchitic
patients, estimated that they tended to be-
come worse when daily levels of smoke ex-
ceeded 300 p.g/m3 with  S02  over 600 /*g/m3.
Angel et al. made somewhat similar obser-
vations with  smoke above  400 /jg/m3 and
S02 over 460 jug/m3.
  Winkelstein  found  in Buffalo that  in-
creases in  the mortality rate were signifi-
cantly linked  to higher levels of suspended
particulate  pollution.  His  studies  showed
that mortality from all causes, from chronic
respiratory  diseases, and from  gastric car-
cinoma increased from the lowest of his
five levels of pollution  (less than 80 /*g/m3)
through  the three higher ranges, after the
effects of socioeconomic status had been con-
sidered.  Zeidberg found in Nashville sig-
nificant increases  in all respiratory deaths
at soiling levels over 1.1 cohs annual aver-
age.  Neither of these  studies took smoking
habits into account, and the Nashville  study
only  partially allowed  for  socioeconomic
factors.
  Studies of illness in relation to residence
in more- and less-polluted areas contribute
additional information.  Fletcher et al.  noted
a proportional decline in the production of
morning sputum in chronic bronchitics in
West London from 1961 to  1966 as smoke
pollution in their residence areas declined
from 140 jug/m3 annual mean.  Douglas and
Waller found  an increase in frequency and
severity of lower respiratory illness at smoke
and  S02  levels over 130 /tg/m3 annual aver-
age.  The Sheffield study by Lunn et al.2
shows similar differences  occurring with
some morbidity  measures  between  about
100 ng/m3 and 200 ^g/m3 of smoke,  and for
others between  200 /ig/m3  and 300 /*g/m8
annual average.
  A  study  of British  workmen found in-
creased respiratory illness absence in  areas
with smoke levels in excess of 200 /*g/m3.
  Physiologic studies of lung function have
also been made in both adults and children.
On the basis  of  present limited knowledge
it appears that the alterations found may be
both temporary and permanent.  The obser-
vations now  available  relate to  long-term
residence in  a  given area.  The  Sheffield
       170

-------
Table 11-6.—SUMMARY TABLE OF EPIDEMIOLOGICAL STUDIES
1
"3™
•a a
a>.S
T3 *>
Is
Health Index §
VI
A. Acute episodes — Mortality:
1. London, winter
1958-59.
London, winter
1958-59.
London, winter
1958-59.
2. London, fog
episodes,
1954, 1955,
1956, 1957.
London, fog
episode 1962.
3. New York,
November,
1953.
4. New York,
De.cember,
1962.
New York,
December,
1962.
5. New York,
January,
1963.
6. Detroit, >200
September, 3 days
1952.
7. Osaka, 1000
December, (sic)
1962.
B. Acute episodes — Morbidity:
1. New York, . . .
November,
1953.
2. New York, 	
November,
1966.
C. Long-term air pollution — Day
1. London winters, _ _ .
1958-59,
1959-60.
c
~~? ®
<5 2 M^3 o!
« 1 S3?
£S • '2 > m ff
«pq g £ ca v g
3^. £~| £*§
.3 g " g^ gl s
i"S ~1 r§-s
M"c •-§•» *"8 S
* ^"w O-^ "g
| 0 M g " Findings
M U 42
rise of 200 . _ - rise of 75 Correlation of daily mortality (all
causes) and daily bronchitis
mortality with B.S.M. Signifi-
cant positive association of SO2
and deaths.
1000 _ 715 Increase in mortality (all causes)
750 715 Re-analysis of data of reference 4
2000 1200 Bronchitis death rate increased,
other causes rise also.
2000 1145 Death rates of elderly rose;
greater proportionate rise in
bronchitis deaths.
[51 2460 Excess deaths all age groups;
lag effect noted.
No excess deaths
[6] 2145 Excess deaths in 45-64 age group
and over 65 age group.
[6] 1715 Peak in death rate superimposed
on high deaths due to influenza.
2860 (max) Excess infant mortality and
cancer mortality.
_ - _ . 285 Sixty excess deaths
[3] 715 Increased upper respiratory
infection and cardiac disease
morbidity.
Increased emergency visits for
bronchitis and asthma; analysis
complicated by Thanksgiving
holiday.
to day variations in mortality and morbidity:
>500 >400 Increases in mortality and
morbidity appear positively
associated with fluctuations in
air pollution.
Reference
11
12
13
8,9
10
14
15
16
16
19
20
21
22
12

                                                         17]

-------
              Table 11-6 (continued).—SUMMARY TABLE OF EPIDEMIOLOGICAL STUDIES




+J
la
rrt bfl
P. *
•rt  x G
a g 3
•tjs
bo
sis

^ 
-------
              Table 11-6 (continued).—SUMMARY TABLE OF EPIDEMIOLOGICAL STUDIES
                         -S
                         a
                                     w
                                             o
                                             g
                                           si
           >*e
           a 
fe
Findings ^
K
    6. Nashville,
          Tenn.,
          1940-60.
                                                  30
E.  Long-term air pollution—Geographic variations in morbidity:
    1. Genoa, Italy	  	   	  	   	
                        Air pollution levels did not re-
                        late to deaths due to cancer of
                        bronchus, trachea or lung.
                        Mortality effects also seen in
                        area with 80 Mg/m3 to 100
                        Mg/m3.
                       'High" pollution related to in-
                        creased respiratory disease
                        mortality. Lung and  bronchial
                        cancer, bronchitis, and
                        emphysema mortality not
                        clearly related.
    2. Japan	   	   n.a.
    3. U.K.-U.S.       U.S.     U.K.
          Comparison.     100      200
                                                       n.a.
                                                   U.S. 12-30
                                                   U.K. 60-300
                              (Levels not directly comparable)
    4. U.K.
                        In-
                         adeq.
5.  Canada,
     4 cities.
    6. Berlin,
         N. Hamp-
         shire, Chilli-
         wack, B.C.
    7. Nashville,
         Tenn.
F.  Long-term air pollution—Incapacity for work:
    1. U.S	  100-     	  _.
                          190
[11.6]   [SOsl.3]
 (lyr-
 av.)
	  Inadeq.
                                          34.9
        [SOsO.4]
        [SO30.05]
38,39
                                                                                                      41
                                                                                                      42
                                                            43
                                                                                                      44
   45
Frequency of bronchitis signifi-
   cantly associated with SO2, not
   with suspended matter of
   dustfall.
Gradient of respiratory disease
   morbidity from industrial to
   rural sites.
Increase of smoke concentration
   from 100 /jg/m3 to 200 jug/m3
   and equivalent SOa increase
   leads to higher risk to older
   men of  poorer lung function and
   increased chronic respiratory
   disease.
Differences in area respiratory
   morbidities attributed by authors
   to difference in air pollution.
Increased  severe bronchitis, poor
   lung function performance in
   "dirty" cities versus "clean"
   cities.
No observable differences	   46-48
                                                                Cardiovascular disease directly         49
                                                                  correlated with aerometric data.
                                                                  No increased respiratory disease
                                                                  morbidity.

                                                                No correlation of absence in            50
                                                                  excess of 7 days with sus-
                                                                  pended particles. Significant
                                                                  correlation of absence with
                                                                  "suspended participate
                                                                  sulfate."
                                                                                                173

-------
              Table 11-6 (continued).—SUMMARY TABLE OF EPIDEMIOLOGICAL STUDIES
                                    OJ
                                     0) fl
                                   >H +i £3

                                  ||3
                                                 o
                                                .
                                              |§
                                                           §
                                                         &'•§&
                                                         i£s
                                                         ra  1000 (2
                                  consecu-
                                 tive days)
    3.  Greater Lon-     	  100-200
         don, U.K.
                                 400
    4. New York,
         N.Y.
    Studies of children:
G.  1. U.K.,            >130
         1946-61.

    2. Sheffield, U.K.,   100
         1963-65.

    3. Ferrara district,  n.a.
         Italy,
         1959-64.

    4. Japan	  	
                                                      150-250

                                                      400
                                             [2.7]    540 (7 yr.
                                              (7 yr.    mean).
                                              mean).

                                             	   >130
                                             60
                                                      >120
                                                      n.a.
[S030.02]
    5. Japan.
                        n.a.
    6.  Irkutsk,
         U.S.S.R.,
         time period
         not definite.
H.  Studies of pulmonary function:
    1.  U.K.-U.S.        	  -
         Comparison.
                                                      n.a.
    2. Japan.
Bronchitis caused absence greater      34
  than expected by factor of 2 in
  four of five episodes.
Lowest bronchitis inception rates__     51

Highest bronchitis inception rates.
  Significant correlation of bron-
  chitis incapacity with smoke
  and SO 2 for all age groups, and
  men 35-54 and 55-59.
No strong relation between            52
  respiratory illness absence and
   COH or SO 2.

Increased frequency and severity       54
   of lower respiratory diseases in
   school children.
Increased association of "res-          56
   piratory infections" for school
   children  age 5-6.
No correlation of onset of acute        57
   respiratory illness to changing
   pollutant  levels except in poor-
   est socioeconomic area.
Total vital capacity of children in      42
   polluted and nonpolluted areas
   the same. Fluctuations in mean
   peak flow rates larger for chil-
   dren in polluted areas than in
   less polluted areas.
Peak flow rates decreased more in      20
   winter for children in polluted
   areas than in less polluted areas.
Possible relation of respiratory         58
   disease and residence in area of
   pollution.
             FEVi.o performance of U.K.           43
               workers decreased compared to
               U.S. counterparts.
             Total vital capacity of children in      42
               polluted and nonpolluted areas
               the same. Fluctuations in mean
               peak flow rates larger for chil-
               dren in polluted areas than in
               less polluted areas.
         174

-------
             Table 11-6 (continued).—SUMMARY TABLE OF EPIDEMIOLOGICAL STUDIES
                      o,
                      •a
    Health Index
                               si!
                                         P
w
o
o
                                                   ei! a> g
                                                   >» rto
Findings
    3. Japan	  	   	   	  	  Peak flow rates decreased more in      20
                                                              winter for children in polluted
                                                              areas than in less polluted areas.
    4. Pennsylvania,    	   	   	  	  Possible relation of dustf all and        59
        2 com-                                                SO 2 differences in  average and
        munities.                                              specific airway resistance of
                                                              subjects in the two com-
                                                              munities.
    5. Sheffield, U.K.	   100          	  275          Reduced FEVo.w and FVC in          56
                                                              areas of highest pollution.
                                                              Possible persistence of respira-
                                                              tory function deterioration
                                                              related to residence in area of
                                                              high pollution.
I.   Studies of panels of bronchitic patients:
    1. London,        300     	   	  >600        Acute worsening of symptoms in       60
        November,                                             bronchitis patients.
        1955-May,
        1956.
    2. U.K., October,   400     	   	  460          Possible increase in respiratory         62
        1962-April,                                             disease attack rates.
        1963.
    3. Rotterdam,     	   n.a.          	  n.a.          No indication of residence  effect       63
        Netherlands.                                            on bronchitis symptoms.
    4. London	  	   140 Mg/m3    	  200 itg/m3    Decrease in morning sputum          64
                              declining             declining     volume with decreasing air
                              to                  to           pollution levels in bronchitis
                              60 /ig/m3.            160 jug/m3.    patients under observation dur-
                                                              ing 6 years.
study shows reduced pulmonary function in
the children in  the most polluted area, i.e.,
where smoke  concentration  is  above  300
/ig/m3.  Studies in  Japan show  a decrease
in pulmonary function in school children liv-
ing in areas of high  dustfall as compared
with  those living in low dustfall areas. In
Osaka the dustfall  levels were  6.5  gm/m2-
month and 13.3  gm/m2-month.
  The analyses of the numerous epidemio-
logical studies  discussed clearly indicate an
association between air pollution, as meas-
ured  by particulate matter accompanied by
sulfur dioxide,  and health effects of  varying
      severity.  This association is most firm for
      the short-term air pollution  episodes.
         There are probably no communities which
      do not contain a reservoir of  individuals with
      impaired  health  who are prime targets for
      the effects of elevated  levels of particulate
      matter and  sulfur oxides. However, to show
      small changes in deaths associated with co-
      incident higher  levels of air pollutants re-
      quires extremely large populations. In small
      cities,  these small  changes cannot be de-
      tected statistically.
         The epidemiologic studies  concerned  with
      increased mortality also show increased mor-
                                                                                    175

-------
bidity.   Again,  increases  in morbidity  as
measured, for  example,  by increases in hos-
pital admissions or  emergency  clinic visits,
are  most easily detected  in major urban
areas.
  It  is  believed that, for  the  large urban
communities which  are routinely  exposed
to relatively high  levels of pollution, sound
statistical analysis can detect with confidence
the  small changes in daily mortality which
are  associated  with  functions  in pollution
concentrations.  Unfortunately,  only limited
analysis  has thus  far been made, and this
has  been attempted  only in London and in
New York.
  The association between  longer-term com-
munity  exposures  to particulate matter for
respiratory  disease incidence and prevalence
rates is conservatively believed to be inter-
mediate in its  reliability. Because of the re-
enforcing nature  of the studies  conducted
to date,  the conclusions to be  drawn from
this type of study can  be  characterized as
probable.
  The  association between long-term  resi-
dence in a polluted area and chronic disease
morbidity and mortality is somewhat more
conjectural.  However,  in  the absence  of
other explanations, the findings of increased
morbidity and of increased death rates for
selected  causes,  independent  of  economic
status,  must still  be considered consequen-
tial.

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-------
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   Ferara."  Arch. Environ.  Health.  18:495,  502,
   1969.
58. Manzhenko, E. G. "The Effect of Atmospheric
   Pollution on the Health of Children."  Hyg. Sanit.
   31:126-128, 1966.
59. Prindle, R.  A., Wright, G. W., McCaldin, R. O.,
    Marcus, S. C., Lloyd, T. C., and  Bye,  W.  E.
    "Comparison of Pulmonary Function and Other
    Parameters in Two Communities with Widely
    Different Air  Pollution Levels."  Am. J. Public
    Health 53:200-218, 1963.
60.  Lawther, P.  J. "Climate, Air   Pollution, and
    Chronic Bronchitis." Proc. Roy.  Soc. Med. 51:
    262-264, 1958.
61.  Waller, R.  E.  and Lawther,  P. J. "Some Obser-
    vations on London Fog." Brit. Med. J. 4952:1356-
    1358, Dec. 3, 1955.
62.  Angel,  J. H.,  Fletcher, C. M., Hill, I.  D., and
    Tinker,  C.  M.  "Respiratory  Illness in  Factory
    and  Office  Workers."  Brit.  J.  Diseases  Chest
    59:66-79, 1965.
63.  Biersteker,  K.  "Air Pollution and  Smoking  as
    Cause of Bronchitis among 1,000 Male Munici-
    pal Employees in Rotterdam (The Netherlands).
    Arch. Environ. Health. 18:531-535,  1969.
64.  Fletcher, C. M., Tinker,  B.  M.,  Hill,  I. D., and
    Speizer, F. E. "A Five-Year Prospective  Field
    Study  of Chronic  Bronchitis." Preprint.   (Pre-
    sented  at  the llth Aspen  Conference on Re-
    search  in Emphysema June 1968.)
        178

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         Chapter 12
SUMMARY AND CONCLUSIONS

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                            Table of  Contents
                                                                         Page
A. SUMMARY   ....                     .181
   1. General                                                            181
   2. Effects on Health            .                .                .182
   3. Effects on Climate Near the Ground                         ...    184
   4. Effects on Visibility         .                .                .184
   5. Effects on Materials                         .   .                    185
   6. Economic Effects of Atmospheric Particulate Matter        .     .     186
   7. Effects on Vegetation                   .               ...      186
   8. Effects on Public Concern .                                 .  .      187
   9. Suspended Particles as a Source of Odor               .     .      .    187
B. CONCLUSIONS                                                .      187
   1. Effects on Health                     ...        ....           188
   2. Effects on Direct Sunlight                                  ....    189
   3. Effects on Visibility                       .     .                    189
   4. Effects on Materials .   .                         .         	    189
   5. Effects on Public Concern                                       .189
C. RESUME                         .        	    189
  180

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                                      Chapter 12

                          SUMMARY AND CONCLUSIONS
             A.   SUMMARY

               1.  General
  The particulate matter commonly  found
dispersed in the atmosphere is composed of a
large variety of substances. Some of these—
fluorides, beryllium, lead, asbestos, for ex-
ample—are known to be directly  toxic,  al-
though  not necessarily  at levels  routinely
found in the atmosphere today. The evidence
suggests that there may very well  be others
whose toxic effects have not yet been recog-
nized. To evaluate fully the effects  on health
and welfare of the presence of each of these
substances  in  the air requires that they be
given individual  attention, or attention as
classes  of  similar substances.  Such evalua-
tions  will be made in separate documents.
  This  document considers the effects  on
man and his environment of undifferentiated
particulate matter. These effects oftentimes
are produced by a combination of particulate
and gaseous pollutants, the contributions of
which are  difficult to distinguish. Moreover,
laboratory  studies have  shown that a  com-
bination of particulates and gases  may pro-
duce  an effect  that is greater than the sum
of the effects caused by these pollutants  in-
dividually.
  Particles in the  atmosphere,  whatever
their  individual  characteristics,  exhibit  a
number of  similar properties, which are for
the most part dependent on the particle size.
Most  of the available studies on the effects
of particulate air pollution, however, do not
specify  particle size, and this document is
limited  to  treating particulate matter as a
whole, and to considering the effects which
are generally  associated  with the  presence
of particles in the air.
  Particulate air  pollution, as used in this
document, refers to any matter dispersed in
the air, whether solid or liquid, in which the
individual  particles  are larger than  small
molecules but smaller in diameter than 500/t.
(One ju, in one millionth of a meter.) Particles
in this  size range stay in the air anywhere
from a  few seconds to several months.
  Generally speaking, particles smaller than
1 fi in diameter originate in the atmosphere
principally through  condensation and  com-
bustion, while larger particles, with the ex-
ception of  rain, snow,  hail,  and sleet, arise
principally   from  comminution.   Particles
larger  than  10 /u, in diameter  result from
mechanical processes such as wind erosion,
grinding and spraying, and the pulverizing
of  materials by vehicles  and  pedestrians.
Particles between 1 /* and 10 /*. in diameter
usually  include local  soil, process dusts and
combustion  products  from  local industries,
and, for maritime locations, sea salt. Com-
bustion products and  photochemical aerosols
make up a large fraction of the particles in
the  range  0.1  # to  1  /i  in diameter,  and,
although particles below  0.1 //, in diameter
have not been extensively  identified chem-
ically, the typical urban increase over natural
levels of particles in this size range seems to
be entirely due to combustion.
  Particles of  a size less than 0.1 /* in di-
ameter  are characterized by random motions
produced by collisions  with gas  molecules.
They are highly concentrated, move rapidly,
collide frequently, and through sorption and
nucleation  of gas  molecules and  adhesion
with other  particles grow  larger  quickly.
Particles larger than 1 /x have significant set-
tling velocities, and their motions may devi-
ate significantly from the motion of the air.
  Measurements of  dustfall are  commonly
used to indicate the  mass concentration  of
                                                                              181

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the settleable portion of participate air pollu-
tion. Typical values for cities are 10 to 100
tons/mile2-month;  as high  as 2,000 tons/
mile2-month have been measured in the vicin-
ity of especially offensive sources. Levels  of
dustfall have apparently declined  in some
American cities, and  dustfall measurements
are probably not useful as an index of over-
all particulate air  pollution. However, dust-
fall  itself  constitutes a  nuisance, and  its
measurement can be used as an index of the
dirtiness of air pollution.
  Several methods are available for measur-
ing  suspended  particulate concentrations.
The most commonly used device is the high-
volume  sampler, which  consists  essentially
of a blower and a filter, and which is usually
operated in a standard  shelter to  collect a
24-hour sample. The sample is weighed  to
determine concentration,  and is usually ana-
lyzed chemically. The hi-vol is considered a
reliable instrument for measuring the weight
of total particulate matter. Chemical analysis
of the hi-vol sample, however, may be limit-
ed: the filter material may contaminate the
sample; different substances in the sample
may react with each other; and  losses may
occur  through  volatilization of material.
Tape samplers, which collect suspended par-
ticulate matter  on filters and analyze the
sample  optically, are also in common  use.
While  these  samplers are inexpensive  and
rugged, they yield  data which cannot always
be easily interpreted in terms of  particulate
mass concentration. Other techniques avail-,
able for measuring particulate pollution in-
clude optical systems, which provide an indi-
cation of  concentration   without requiring
that a sample be taken.
  The averaging time used  for  measuring
suspended particulates is not as significant a
factor as  it is for gaseous pollutants.  The
basic unit of time  is 24 hours. Values taken
over this period may be combined into week-
ly, monthly, seasonal, and annual means  as
required.  The  relationships  between daily
and  other longer time periods in  the United
States is known with some degree of precis-
ion,  as data exist for a 10-year period.
  Most of the  data on mass concentrations
of suspended  particulates come from the
National   Air  Surveillance   Networks,
(NASN), which uses the high-volume samp-
ler.  NASN  currently  operates  some 200
urban  and  300 nonurban stations, and  is
supplemented by State and local networks.
From the NASN data, the annual geometric
mean concentrations of suspended particu-
late  matter in urban  areas range  from 60
/*g/m3 to about 200 /*g/m3. The maximum 24-
hour average concentration is about  three
times the annual mean, but values  of  seven
times the annual mean do occur. Mean par-
ticulate concentrations correlate, in general,
with urban population class, but the range
of concentrations for any  class is broad, and
many smaller communities have higher con-
centrations than larger ones. For nonurban
areas the annual geometric mean is  typically
between 10 jug/m3 and  60
          2.  Effects on Health
  For the most part, the effects of particu-
late  air pollution  on health are related  to
injury to the surfaces of the respiratory sys-
tem. Such injury may be permanent or tem-
porary. It may be confined to the surface,  or
it may extend beyond, sometimes producing
functional or other  alterations. Particulate
material  in  the  respiratory tract  may pro-
duce injury  itself,  or it may act in conjunc-
tion  with gases, altering their sites or their
modes of action.
  Laboratory studies of man and other ani-
mals show clearly that the deposition, clear-
ance, and retention of inhaled particles is a
very complex process, which is only begin-
ning to be understood. Particles cleared from
the  respiratory tract  by transfer to the
lymph, blood, or gastrointestinal tract may
exert effects elsewhere.  Few studies have in-
vestigated the possibility of eye injury by
particles in the air; only transient eye irrita-
tion  from large dust particles presently  is
known to be a problem.
  The  available  data  from   laboratory
experiments do not provide suitable quantita-
tive relationships for establishing air quality
criteria for  particulates. The constancy  of
population exposure, the constancy  of tem-
perature and humidity, the use of young,
normal, healthy animals, and  the primary
focus on short-term  exposures in many lab-
oratory studies make  extrapolation  from
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these studies of limited value for the general
population, and  singularly risky for special
risk groups within the  population. These
studies do, however, provide valuable inform-
ation on some of the bioenvironmental rela-
tionships that  may be involved in the effects
of particulate air pollution on health.  The
data they provide on synergistic effects show
very clearly that information derived from
single-substance exposures should be applied
to ambient  air  situations only with great
caution.
  Epidemiological studies do not have  the
precision of laboratory studies, but they have
the advantage of being  carried  out under
ambient air conditions. In most epidemiologi-
cal studies, indices  of air pollution level  are
obtained by measuring  selected  pollutants,
most commonly particulates and sulfur com-
pounds. To use these same studies to estab-
lish criteria for individual pollutants is justi-
fied by the experimental data on interaction
of pollutants.  However,  in reviewing the re-
sults  of  epidemiological investigations it
should always  be remembered that the speci-
fic pollutant under  discussion is being used
as an index of pollution, not as  a physico-
chemical entity.
  In epidemiologcial studies consistency of
results at different times and places is  im-
portant in determining  the  significance of
observations. However, while polluted air  has
many similarities from  place to  place  and
from time to  time, it is not identical in all
communities or  at  all times, and  complete
consistency  between epidemiological studies
should not be expected. There are not a large
number of  suitable epidemiological studies
available at present, but those that are avail-
able show some  consistency in the levels at
which effects were observed to occur.
  Considerable data have been presented on
a number of air pollution episodes in London
and  in New York City.  In reviewing these
data it  should be remembered that British
air pollution measurements are not entirely
comparable  with American  measurements.
The only published comparison indicates that
the British method of measuring particulates
tends to give somewhat  lower readings than
American methods.
  Excess deaths and a considerable increase
in illness have been observed in London at
smoke levels above 750  /*g/m3 and  in New
York at a smokeshade index of 5-6 cohs. Sul-
fur oxides pollution levels were also high in
both  cases. These unusual short-term, mas-
sive exposures result in  immediately appar-
ent pathologic effects, and they represent the
upper limits of the observed dose-response
relationship  between  particulates  and  ad-
verse effects on health.
   Daily averages of smoke above 300 /ig/m3
to 400 p.g/m3 have been associated with acute
worsening of chronic bronchitis patients in
England.  No comparable data  are available
in this country. Studies of British workmen
found that increased absences due to illness
occurred  when  smoke  levels exceeded 200
/*g/m3.
   Two recent British studies showed  in-
creases  in  selected respiratory illness  in
children to be associated with  annual mean
smoke levels  above 120 jug/m3. Additional
health changes were associated with higher
levels. These  effects may be of substantial
significance in the natural history of chronic
bronchitis.  Changes  beginning in  young
children may culminate in bronchitis several
decades later.
   The lowest  particulate  levels  at which
health effects appear to have occurred in this
country are reported  in studies of Buffalo
and  Nashville.  The  Buffalo study  clearly
shows increased  death rates from  selected
causes in males and females 50 to  69 years
old at annual geometric means of 100 /tg/m3
and over. The study suggests that increased
mortality may have been  associated with
residence in  areas  with 2-year geometric
means of 80 pg/m3 to 100 /xg/m3. The Nash-
ville  study suggests increased  death rates
for selected causes at levels  above  1.1 cohs.
Sulfur oxides pollution was also present dur-
ing the  periods  studied. In neither  study
were  the smoking  habits  of the  decedents
known.
   Corroborating  information  is   supplied
from  Fletcher's study of West London work-
ers between the ages of 30 and 59. The data
indicate that with a decrease of smoke pollu-
tion  (yearly mean)  from  140  /xg/m3  to 60
/xg/m3, there was an associated decrease  in
mean  sputum volume. Fletcher noted that
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there may have been changes in the tar com-
position of cigarettes during the period stud-
ied; such  a change could affect the findings.
This study provides one of the rare oppor-
tunities to examine the apparent improve-
ment in health that followed an improvement
in the quality of the air.

 3.  Effects on Climate Near  the Ground
   Particles suspended  in the air scatter and
absorb sunlight, reducing the amount of solar
energy reaching the earth, producing hazes,
and  reducing  visibility. Suspended particu-
late matter plays a significant role in bring-
ing about precipitation, and there is some
evidence that  rainfall in cities has increased
as the cities have developed industrially.
   Suspended particulate matter, in the con-
centrations routinely found in  urban areas,
considerably   reduces  the  transmission  of
solar  radiation to  the ground,  creating an
increased demand  for  artificial light.  The
effect is more  pronounced in the winter than
in the summer, when particulate pollution
loadings are higher, and sunlight must pene-
trate  more  air to reach  the  ground.  For
similar reasons the effect  is also  more pro-
nounced during the workweek than on week-
ends, during industrial booms, and in higher
latitudes.  For a typical urban  area  in the
United States, with a geometric mean annual
particulate  concentration  of  roughly  100
/ug/m3, the total sunlight, including that re-
ceived directly from the sun and that  reflect-
ed by  the sky, is  reduced five percent for
every doubling of particle concentration. The
reduction is most  pronounced on ultraviolet
radiation.
   For urban  areas in the middle and high
latitudes,  particulate  air  pollution may re-
duce direct sunlight by as much as one-third
in the summer and as much as  two-thirds in
the winter. This  effect may have implica-
tions  for the delicate heat balance  of the
earth's atmospheric system. In spite of an
increase in the carbon  dioxide content of the
atmosphere  over the past  several decades,
which  would  presumably  bring  about  an
increase  in atmospheric temperature, mean
worldwide temperatures have been decreas-
ing since the  1940's. Increased  reflection of
solar radiation back to outer space, brought
about by increased concentrations of particu-
late air pollution, may be more than cancel-
ling out the climatic effect of  the increased
carbon  dioxide. That worldwide particulate
air pollution has been increasing is evidenced
by the fact that in  the United  States and in
other  countries, turbidity,  a   phenomenon
produced  by the back-scattering of  direct
sunlight by particles in the air,  has increased
significantly over the last several decades.
         4.  Effects  on Visibility
  Particles suspended in the air reduce vis-
ibility,  or  visual range, by scattering  and
absorbing light coming  from both an  object
and  its background, thereby  reducing the
contrast between them. Moreover, suspended
particles scatter light into the  line of sight,
illuminating the air between, to further de-
grade the contrast between an object and its
background.
  The scattering of light into and out of the
line of  viewing by particles' in the narrow
range of 0.1 p. to 1 p. in radius has the greatest
effect on visibility. Certain characteristics of
behavior of these particles make it  possible
to formulate  a useful approximate relation-
ship between visual range and concentrations
of particulate matter:
                   AxlO3
              LT—-
                    G'
where G' = particle concentration
      Lv = equivalent visual range, and

      A = 1.2.' for LT expressed in kilome-
             O.o
          ters and 0.75

for Lv expressed in miles
1.5
0.38
The value 1.2 for A is the mid-range value
empirically obtained from observations in a
variety of air pollution situations. The data
indicate  that the range  0.6  to 2.4 covers
virtually all  cases studied. The relationship
does not  hold at relative humidities above 70
percent,  nor  does it apply to  fresh plumes
from  stacks, and it may not  hold for the
products of photochemical reactions. A com-
panion document, Air Quality Criteria For
Sulfur Oxides, discusses  a relationship be-
tween  levels of  sulfur dioxide  and visual
range  at various relative  humidities.
       184

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  Within the limitations prescribed, the re-
lationship provides a useful means of esti-
mating approximate visual range from par-
ticulate concentrations. In addition to aesthe-
tic degradation of the environment, reduced
visibility  has serious  implications for safe
operation of aircraft and motor vehicles. At
a visual range of less than 5  miles, opera-
tions  are slowed at airports because of the
need  to maintain larger  distances  between
aircraft.  Federal Aviation  Administration
restrictions  on  aircraft operations become
increasingly severe as the  visual range de-
creases below 5 miles. Using the  upper and
lower  bounds of the relationship described
above, visibility  could be 5 miles at a par-
ticulate loading as high as 300 /xg/m3 or as
low as 75 jug/m3. However, on the average,
visibility  can be expected to be reduced to
approximately 5  miles at a particulate con-
centration of 150 jug/m3. At a level of 100
/ig/m3, visibility is reduced to 73/2 miles. This
limited distance,  however,  may be related to
particulate concentrations as low as 50 /ng/m3
and as high  as 200 /ug/m3.

         5.   Effects on Materials

  Particulate air pollution causes a  wide
range of damage to materials.  Particulate
matter may  chemically   attack  materials
through  its  own instrinsic corrosivity,  or
through the corrosivity of substances absorb-
ed or adsorbed on it. Merely by soiling ma-
terials, and  thereby causing their more fre-
quent  cleaning, particulates can  accelerate
deterioration.
  Laboratory and  field  studies  underscore
the importance of the  combination of par-
ticulate matter  and corrosive  gases in the
deterioration  of  materials. On the  basis of
present knowledge, it is difficult to  evaluate
precisely the relative contribution of each of
the two classes  of pollution; however, some
general conclusions may be drawn.
  Particulates play a role in the corrosion of
metals.  In   laboratory  studies,  steel test
panels that  were dusted with  a number of,
active hygroscopic particles commonly found
in the atmosphere corroded even in clean
air. Corrosion rates were low  below a rela-
tive humidity of 70 percent; they increased
at relative humidities above 70 percent; and
they greatly increased when traces of sulfur
dioxide were added to the laboratory air.
  It is  apparent that the accelerated corro-
sion rates of various metals in urban and
industrial  atmospheres are  largely  the  re-
sult of relatively higher levels of particulate
pollution  and sulfur  oxides pollution.  High
humidity  and temperature also play an im-
portant synergistic part in this corrosion re-
action.  Studies  show  increased corrosion
rates in industrial areas where air pollution
levels, including sulfur oxides and  particu-
lates, are  higher. Further, corrosion  rates
are higher  during  the fall and winter sea-
sons when particulate and sulfur oxides pol-
lution is more severe, due to a greater con-
sumption of fuel for heating.
  Steel samples corroded 3.1 times faster in
the spring  of  the year in New  York  City,
where  annual  particulate  concentrations
average 176 ^g/m3, than did similar samples
in  State  College, Pennsylvania, where the
average concentrations  were  estimated to
range from 60 /tg/m3 to 65 /ig/m3. In the
fall of the year, when particulate and sulfur
oxide concentrations in New York were con-
siderably higher than in the spring, the steel
samples in New York  corroded six times
faster than the samples at State  College.
Similar  findings  were   reported  for  zinc
samples. Moisture may have contributed to
the corrosion.
  In Chicago and St. Louis, steel panels were
exposed at a number" of  sites, and measure-
ments taken of corrosion  rates and of levels
of  sulfur  dioxide and particulates. In  St.
Louis, except for one  exceptionally  polluted
site, corrosion losses correlated well with sul-
fur dioxide levels,  averaging 30 percent to
80  percent higher  than  losses measured in
nonurban  locations. Sulfation rates in  St.
Louis, measured by lead peroxide candle, also
correlated well  with weight  loss   due to
corrosion.  Measurements of dustfall in  St.
Louis, however, did not correlate significant-
ly with corrosion  rates.  Over  a 12-month
period in Chicago, the corrosion rate at the
most  corrosive site (mean S02 level of 0.12
ppm) was about 50 percent higher than at
the least  corrosive site (mean S02  level of
0.03 ppm). Although suspended particulate
                                                                              185

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levels measured in Chicago with high-volume
samplers also correlated with corrosion rates,
a covariance analysis indicated that sulfur
dioxide concentrations  were  the dominant
influence on corrosion. Based  on these data,
it appears that considerable corrosion may
take place (i.e., from 11 percent to 17 per-
cent weight loss  in steel panels) at annual
average sulfur dioxide concentrations in the
range of 0.03 ppm to 0.12 ppm, and although
high particulate  levels tend  to  accompany
high sulfur dioxide levels, the sulfur dioxide
concentration   appears  to  have the  more
important influence.
  Particulate  air pollution  damages electri-
cal  equipment of all kinds. Oily or tarry par-
ticles, commonly found  in urban and indus-
trial areas, contribute to  the  corrosion and
failure of electrical contacts and connectors.
Dusts can interfere with contact closure, and
can  abrade contact  surfaces. Hygroscopic
dusts will absorb water and form thin elec-
trolytic films which are corrosive.
  Particulates  soil and damage buildings,
statuary, and other surfaces. The effects are
especially severe in urban areas where large
quantities  of  coal  and sulfur-bearing fuel
oils are burned. Particles may act  as reser-
voirs of acids, and thereby sustain a chemical
attack that will deteriorate even the more
resistant kinds of masonary. Particles stick
to surfaces, forming a film of tarry soot and
grit which oftentimes is not washed away by
rain.  Considerable  money  and effort have
been spent in  many  cities  to sandblast the
sooty layers  that accumulate  on buildings.
Water-soluble salts, commonly found in ur-
ban  atmospheres, can blister paint. Other
particles may  settle on newly painted sur-
faces,  causing  imperfections, thereby  in-
creasing the frequency with which a surface
must be painted.
  The soiling of textiles by the deposition of
dust and soot on fabric fibers not only makes
them unattractive, and thereby  diminishes
their use, but results in abrasive wear of the
fabric when  it is cleaned. Vegetable fibers,
such as cotton and linen, and synthetic nylons
are particularly susceptible to chemical at-
tack  by  acid  components   of   airborne
particles.
   6.   Economic Effects of Atmospheric
            Particulate Matter

  It is not possible at the present stage of
knowledge to  provide accurate measures of
all the costs imposed on society by particu-
late  air   pollution.  Selected  categories  of
effects can be quantified; it is obvious that
these estimates represent a significant under-
statement of the total cost.

        7.  Effects on Vegetation

  Relatively little research has been carried
out on the effects of particulate air pollution
on vegetation,  and much of the work that
has been  performed has dealt with specific
dusts, rather than the conglomerate mixture
normally  encountered  in  the atmosphere.
This document reports briefly on some of
these specific particulate studies only to illus-
trate the possible mechanisms through which
particulate matter  may  affect vegetation.
This information is not  presented  for the
purpose of establishing air quality standards
on these specific pollutants.
  There   is   considerable  evidence  that
cement-kiln  dusts  can  damage  plants. A
marked reduction in the growth  of poplar
trees 1 mile from a cement plant was observ-
ed after cement  production was  more than
doubled. Plugging  of stomates by the dust
may have prevented the exchange of gases
in leaf tissue  that is necessary for growth
and  development. Moderate damage to bean
plants  occurred when the plant leaves were
dusted at  the rate of 0.47 mg/cm2-day (400
tons/m2-month) for 2 days and then exposed
to natural dew.  The mechanism through
which  the leaves are damaged  is  not en-
tirely understood, but direct  alkaline dam-
age to tissues beneath the crust formed by
the dust and moisture has been observed. The
deposits may  also  plug stomates  and block
light  needed  for  photosynthesis.  Cement-
kiln  dusts may change the alkalinity of soils
to benefit  or harm  vegetation, depending on
the species.
  Dust deposits  may also eliminate preda-
tors, and  thereby bring on  increased insect
injury to  plants; they may interefere with
pollen  germination;  and they may  make
plants  more susceptible to pathogens.
       186

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   Fluoride dusts apparently have a difficult
time  penetrating  leaf tissue in physiologi-
cally active form, and they are much less dam-
aging to vegetation than is gaseous fluoride.
Soluble fluoride dusts may be  absorbed by
the plant, but the amount is relatively small
compared to that  which can enter the plant
in gaseous form. The evidence suggests that
there is little effect on vegetation at fluoride
particulate  concentrations  below  2  /*g/m3.
Concentrations of this magnitude and above
can  sometimes  be found  in the immediate
vicinity  of  sources of fluoride particulate
pollution; they  are rarely found  in urban
atmospheres.
   Ingestion of particles deposited on plants
can be harmful to animal health.  Fluorosis
and arsenic poisoning have been brought on
through this medium.
   Soot may clog stomates and may produce
necrotic spotting if it carries with it a soluble
toxicant,  such as one  with excess acidity.
Magnesium oxide deposits on soils have been
shown to reduce  plant growth, while iron
oxide deposits on  soils have been shown to
reduce plant growth,  while iron oxide de-
posits appear to have no harmful effects, and
may be beneficial.

      8.   Effects  on Public Concern
   Several studies indicate that there  is  a
relationship  between  levels of  particulate
pollution, used as  an index of  air pollution,
and levels of public concern over the prob-
lem.  A study conducted in 1963 in the St.
Louis metropolitan  region found  a direct
linear relationship between the  fraction of
a community's population who said air pollu-
tion  was  a  nuisance, and  the  annual mean
concentration of particulate air pollution in
the community.  The relationship, which was
derived from data on communities in  the St.
Louis  area  whose  annual  concentrations
ranged from 50 ^g/m3 to  200 /*g/m3, was
formulated as:

          y=0.3x-14
    where y=population  fraction (%)
              concerned,  and
          x=annual geometric mean  par-
              ticle concentration
   It is thought that the reaction to suspended
particulates as  a nuisance probably occurs
at peak  concentrations, and not necessarily
at the  values  representing annual  means.
However, the relationship provides a useful
example of how the nuisance effect of air
pollution relates to concentrations. Approxi-
mately  10 percent of the study population'
considered air  pollution a nuisance in areas
with  suspended  particulates at an  annual
geometric mean  concentration of 80 /ig/m3.
At this same level of pollution, 30 percent of
the  study population was "aware  of" air
pollution. In areas with 120 /^g/m3  (annual
geometric mean), 20 percent were "bothered
by" and 50 percent were "aware of" air pol-
lution; in areas  with an  annual geometric
mean of 160 jug/m3, one-third of the popula-
tion interviewed  were "bothered  by" and
three-fourths were "aware of" air pollution.
   Although data from other studies do not
readily lend themselves to quantitative for-
mulation, they do, in general, support the
relationship reported by the St. Louis study.
A study of  communities  in  the Nashville,
Tennessee, metropolitan area in  1957 found
that at least 10 percent of the population ex-
pressed  concern  about the nuisance of air
pollution at dustfall levels exceeding 10 tons/
mi2-month.

    9.   Suspended Particles as a Sources
                 of Odor

   Particulate air pollution is not ordinarily
considered a  significant   source  of odors.
However, there is evidence that liquid and
even solid particles of some substances may
be volatile enough to  vaporize in the nasal
cavity, and produce  sufficient gaseous ma-
terial to stimulate the sense  of smell. Fur-
ther, particles may carry  absorbed odorants
into the nasal cavity, and there transfer them
to olfactory receptors.  A survey of State and
local air pollution control officials revealed
that  approximately  one-fourth of the most
frequently  reported odors are those which
are known to be, or are suspected to be, asso-
ciated  with particulate  air pollution.  The
sources  of these odorous  particles are div-
erse, including  diesel  and gasoline  engine
exhausts, coffee-roasting   operations,  paint
                                                                             187

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spraying, street paving, and the burning of
trash.
           B.   CONCLUSIONS

  The conclusions which follow are derived
from a careful  evaluation by  the  National
Air Pollution Control Administration of the
foreign and American studies cited in previ-
ous chapters of this document. They repre-
sent the Administration's best judgment of
the  effects that may occur when various
levels of pollution are reached  in the atmos-
phere. The data from which the conclusions
were derived, and the  qualifications which
should be considered in using  the  data, are
identified by chapter reference in each  case.

          1.  Effects on Health

  Analyses  of   numerous   epidemiological
studies clearly  indicate an  association be-
tween air pollution, as measured by particu-
late  matter accompanied by sulfur dioxide,
and  health effects of varying severity.  This
association is  most firm for the short-term
air pollution episodes.
  There are probably no communities which
do  not contain  individuals  with  impaired
health who are  particularly susceptible to
the adverse effects of elevated  levels of par-
ticulate matter and  sulfur oxides. However,
to show small changes  in deaths associated
with coincident higher levels of  air pollutants
requires  extremely  large  populations.  In
small  cities,  these changes  are difficult to
detect statistically.
  The epidemiologic studies  concerned  with
increased mortality also show increased  mor-
bidity.  Again,  increases in  morbidity  as
measured, for example, by increases in hos-
pital admissions or  emergency clinic visits,
are most easily demonstrated in major urban
areas.
  For the large urban communities which
are routinely exposed to relatively high levels
of pollution, sound  statistical  analysis can
show with confidence the small changes in
daily mortality which  are  associated  with
fluctuation in  pollution  concentrations.  Such
analysis has thus far been  attempted  only
in London and in New York.
  The association between longer-term  com-
munity  exposures to particulate matter and
respiratory disease incidence and prevalence
rates is conservatively believed to be inter-
mediate in its reliability. Because of the re-
enforcing nature of the studies conducted to
date, the conclusions to be drawn from this
type of  study can be characterized  as prob-
able.
  The association between long-term resi-
dence in a polluted area and chronic disease
morbidity and mortality is somewhat more
conjectural. However, in the absence of other
explanations, the findings of increased mor-
bidity and of increased death rates for select-
ed causes, independent of  economic  status
must still be  considered consequential.
  Based on the  above guidelines the follow-
ing conclusions are listed in order of reliabil-
ity, with the more reliable conclusions first.
Refer to Chapter 11 for cautions to be taken
in comparing British and American air qual-
ity measurement data.
  a. AT  CONCENTRATIONS  OF  750
p,g/ms and higher for  particulates  on a  24-
hour average, accompanied by sulfur dioxide
concentrations of  715  jug/m3 and  higher,
excess deaths and a considerable increase in
illness may occur. (British  data; see Chapter
11,  Section C-l)
  b. A DECREASE FROM HO ^.g/m3 to 60
       (annual mean) in particulate concen-
trations may be accompanied by a decrease
in mean sputum volume in industrial work-
ers.  (British data; see  Chapter 11, Section
C-4)

  c. IF CONCENTRATIONS ABOVE  300
/j.g/m3 for particulates persist on  a 24-hour
average and are accompanied by sulfur diox-
ide concentrations exceeding 630 /*g/m3 over
the same average  period, chronic  bronchitis
patients will likely suffer acute worsening of
symptoms. (British data; see Chapter  11,
Section C-3)

  d. AT CONCENTRATIONS OVER  200
pg/m" for particulates on a 24-hour average,
accompanied   by   concentrations  of sulfur
dioxide exceeding  250 /*g/m3  over the same
average period, increased absence of indus-
trial workers due to illness may occur. (Brit-
       188

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ish data;  see  Chapter 11,  Section  C-5)
  e. WHERE CONCENTRATIONS RANGE
FROM 100 fj.g/m3 to 130 /j.g/m3 and above for
particulates (annual mean) with sulfur di-
oxide concentrations  (annual  mean)  great-
er than 120 jug/m3, children residing in such
areas are  likely to experience increased inci-
dence of certain respiratory diseases.
  f.  AT CONCENTRATIONS ABOVE 100
fiff/m3 for  particulates  (annual geometric
mean) with sulfation levels above 30 mg/
cm2-mo., increased death rates for persons
over 50 years of age are likely. (American
data; see Chapter 11, Section C-2)
  g. WHERE CONCENTRATIONS RANGE
FROM 80 /j-g/m3 to  100 /j.g/ms for particu-
lates  (annual  geometric mean)  with sulfa-
tion levels of about 30 mg/cm2-mo., increased
death rates for persons over 50 years of age
may occur.  (American data; see Chapter 11,
Section C-2)

       2.   Effects on Direct Sunlight
  AT   CONCENTRATIONS   RANGING
FROM 100  p.g/m3 to 150 p.g/m3 for particu-
lates, where large smoke  turbidity factors
persist, in middle and high latitudes direct
sunlight is reduced up to one-third in sum-
mer  and  two-thirds in winter. (American
data; see Chapter 2, Section C-2)

          3.  Effects on Visibility
  AT  CONCENTRATIONS  OF   ABOUT
150 ii.g/ms for particulates, where  the pre-
dominant  particle size ranges  from 0.2 /x to
1.0 /i and relative humidity is less than 70
percent, visibility is  reduced to as low as 5
miles.  (American data; see Chapter 3, Sec-
tion E-4)
          4.   Effects on Materials
  AT   CONCENTRATIONS   RANGING
FROM 60 /4T/m3 (annual geometric mean),
to 180 ing/ms for particulars  (annual geo-
metric mean), in the presence of sulfur diox-
ide and moisture, corrosion of steel and zinc
panels occurs at an accelerated rate. (Amer-
ican data; see Chapter 4, Section B)

       5.   Effects on Public Concern
  AT CONCENTRATIONS OF APPROXI-
MATELY 70 /j.g/m3 for particulates (annual
geometric mean),  in the  presence-of other
pollutants, public awareness and/or concern
for air pollution may become evident and in-
crease proportionately  up to and above con-
centrations of  200 ng/m* for particulates.
(See Chapter 7, Section B-l)

               C.  RESUME
  In addition to health considerations, the
economic and aesthetic benefits to. be obtain-
ed from low ambient concentrations of par-
ticulate matter as related to visibility, soiling,
corrosion, and  other effects should be con-
sidered by  organizations responsible  for
promulgating ambient air quality standards.
Under the conditions   prevailing  in areas
where  the  studies  were conducted, adverse
health  effects  were noted when the annual
geometric mean level of particulate matter
exceeded 80 jug/m3.  Visibility  reduction to
about 5 miles was observed at 150 jug/m3, and
adverse effects on materials were observed at
an  annual  mean exceeding  60 Mg/m3. It is
reasonable and prudent to conclude that, when
promulgating ambient air quality standards,
consideration  should be  given to  require-
ments for margins of safety which take into
account long-term  effects  on  health and
materials occurring  below the  above levels.
                                                                            189

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APPENDICES

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    area of the filter stain, cm2
                              APPENDIX A—SYMBOLS

                                              b
B
B0
Bz
    turbidity coefficient (empirical), A = 0.5^

    particle concentration in the air, |Ug/m3

    turbidity coefficient, measured on the
      ground

    turbidity coefficient, measured at height
      z above the ground

    light intensity, usually in ergs/cm2/sec

 0   initial or incident light intensity

 T  equivalent visual range, or visibility, but
      calculated on basis of a constant scat-
      tering coefficient, b, along the line of
      sight
p
    probability
P(A)
      solar transmission  factor for atmos-
        phere aerosols; it is a function of A
Q
    particle mass concentration in the air,
      usually in /j.g/m3

    scattering cross-section,  cm2/particle

    derived surface particle concentration,
V
b
    transmissivity, I/I0

    volume of air sampled, m3

    extinction coefficient, m-1(=b
    +b       +b        +b   )
       abs gas     Rayleigh      scat
                                              m
                                              x
                                 abs aerosol
abs aerosol
extinction coefficient due  to  absorption
  by aerosol particles

abs gas
extinction coefficient due  to  absorption
  by gas such as N02

Rayleigh
extinction coefficient due  to  scatter by
  gas molecules

scat
extinction coefficient due  to  scatter by
  aerosols

diameter of a spherical particle, cm

Napierian log base  ( = 2.7182818)

acceleration of  gravity,  cm/sec2

index of refraction

correlation coefficient

settling velocity of a particle, cm/sec

distance, m  or cm

height above ground,  meters

light  scattering coefficient  (empirical)
  relates b to A

turbidity coefficient for A = ly«.

viscosity of air, or other gas, poises

wavelength  of light Angstroms, microns,
  or nanometers

probability  function,  usually  expressed
  asx2 ("Chi square")
       192

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                        APPENDIX B—ABBREVIATIONS
A        Angstrom, lA = l(h8 cm              m3
BTPS    body temperature, pressure,          mg
           saturated                        rni
cm       centimeter, 1cm =10 2m              mi2
cm2      square  centimeter                  min
cm3      cubic centimeter                    ml
CMD     count median diameter              MMD
coh      coefficient  of haze                  mo
DMBA   10-dimethyl-l, 2 benzanthracene      mu
FEV     forced  expiratory volume           /j.
FVC     forced  vital capacity               /ug
g        mass, grams                       ppm
hr       hour                              RUDS
1        liter                              sec
m       length,  meter                       yr
cubic meter
milligram
mile
square mile
minute
milliliter
mass median diameter
month
millimicron,  lm/x=0.001/*
micron, Ip. = ICHcm = 10-6m = 104A
microgram
parts per million
reflectance unit of dirt shade
second
year
                                                                         193

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  To convert —
mg/m3
mg/100 m3
APPENDIX C—CONVERSION FACTORS
                  To—
/tg/1000 m3
,ug SO2/m3
   (0°C, 760 mm Hg)
ppm S02 (vol)
tons/mi2-mo
tons/mi2-mo
tons/mi2-mo
tons/mi2-mo
mg/cm2-mo
g/m2-day
/tor /*m
M
A
A*
bbl
1
ft3
ml
m
Ib
                  /xg/m3
              ppm S02 (vol)
              S0a jig/m3 (0° C, 760 mm Hg)
              mg/cm2-mo
              g/m2-day
              metric tons/km2-mo
              tons/mi2-mo
              tons/mi2-mo
                 m
                 A
                 cm
                 cm
                 gal.
                 ft3
                 1
                 in3
                 ft
                 g
Multiply by-
1000
  10
  35.314

3.5 x 10-*

2860
3.5 x 10-2
1.07 XlO-2
3.5 xlO-1
3.5 XlO5
  28.5
  85.5
  10-6
  10*
  10-8
  55
0.0353
  28.32
6.1X10-2
3.28
453.6
      194

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                             APPENDIX  D—GLOSSARY
Acid, free—an acid which is unneutralized
  by other compounds
Acid, stearic—the most common fatty acid
  occurring in natural animal and vegetable
  fats, almost completely colorless and odor-
  less
Acrolein—a toxic colorless mobile liquid al-
  dehyde with an acrid odor
Adenocarcinoma—a  malignant  tumor  in
  which the cells are arranged in the form
  of glands or gland-like structures
Adenoma—an epithelial tumor, usually be-
  nign, with a gland-like structure
Adhesion—the attraction of two unlike sub-
  stances
Adsorption—the phenomenon by which gases
  are attracted,  concentrated,  and retained
  at a boundary surface
Aerodynamics—a phase of the mechanics of
  fluids, its study  being limited to the re-
  actions caused  by relative motion between
  fluid and solid, the fluid being limited to
  air in most cases but occasionally broad-
  ened to include any gas
Aerosol—a  cloud  of  solid  particles and/or
  liquid  droplets smaller than 10(V in di-
  ameter, suspended in a gas
Aerosol,  bidisperse—an aerosol in which all
  the suspended  particles tend to be of two
  sizes  (diameter)
Aerosol,  monodisperse—an aerosol in which
  all the suspended particles are  of nearly
  equal size (diameter)
Air, residual—the air that stays in the lungs
  after forceful expiration
Air, tidal—the air that is carried to and
  from the lungs during a respiratory cycle
Airway—any part  of the respiratory tract
  through which air passes during breathing
Airway resistance—resistance to the flow of
  air in the passages to the lungs
Albedo—the ratio of the amount of electro-
  magnetic radiation reflected by a body to
  the amount incident upon it, commonly ex-
  pressed as a percentage
Aldehyde—any of a class of organic com-
  pounds containing the group R-CHO, in-
  termediate in state of  oxidation between
  primary alcohols and carboxylic acids
Alveolus (pi. alveoli)—a small, sac-like dila-
  tion at the innermost end of the airway,
  through whose walls  gaseous exchange
  takes place
Analysis, factorial—a method of evaluating
  certain definite integrals  by the use  of
  gamma functions
Anaplasia  (adj. anaplastic)—a'condition in
  tumor cells in which normal functional and
  physical differentiation is lost
Anthracosis—a disease- of the lungs caused
by  inhalation  and  accumulation  of carbon
  particles
Antirachitic—opposing  or  preventing  the
  development of rickets
Aphid (aphis)—a  small  sucking insect; a
  plant louse
Atelectasis—the collapse of all or part of a
  lung,  with resultant  loss  of functioning
  tissue
Attenuation—In  physics,  any  process   in
  which  the flux density  (or power, ampli-
  tude,  intensity, illuminance,  etc.)  of a
  "parallel beam" of energy decreases with
  increasing distance from the energy source
Auscultation (adj. Auscultatory)—the act of
  listening for sounds within the body,  us-
  ually with the use of a stethoscope
Bacillus subtilis—a common  microorganism
  found in soil and water and frequently oc-
  curring as a laboratory contaminant; rare-
  ly implicated in causing disease
                                                                             195

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Benzo  (a) pyrene—a polycyclic aromatic hy-
  drocarbon  which under  certain circum-
  stances has been shown to produce cancer
Bifurcation—a site where a single structure
  divides into two branches
Blistering, osmotic—paint blisters caused by
  moisture picking up water-soluble salts in
  its passage through  the paint film, result-
  ing in an ideal situation for osmosis which
  represents  a tremendous force formation
  of blisters
Bloivby—the   leakage  of gas  or liquid be-
  tween a piston and its cylinder during op-
  eration
Body,  asbestos—a fiber  of asbestos  sur-
  rounded by a deposit of protein  material
Bronchiectasis—a   chronic  dilatation  of  a
  bronchial passage
Bronchiole—one of the finer subdivisions of
  the bronchial tree
Bronchitis—an inflammation of the bronchi,
  usually manifest clinically by  cough and
  the production of sputum
Bronchitis, chronic—a long-standing inflam-
  mation of the bronchi characterized by ex-
  cessive mucus secretion  in  the bronchial
  tree and manifested  by a persistent or re-
  current productive cough.  For the pur-
  poses of definition, these symptoms must
  be present  on most days for a minimum of
  3 months of the year for at least  2 suc-
  cessive years  (American Thoracic  Soci-
  ety)
Bronchoconstriction—a diminution  in the
  size of the lumen of a bronchus
Bronchus (pi. bronchi)—one  of the  larger
  air passages in the lung
Broth—a liquid medium for the  cultivation
  of microorganisms
Capacity, forced  vital (FVC)—the largest
  amount of  gas  which can be forcibly ex-
  pired from the lungs following a maximal
  inspiration
Capacity, functional  residual  (FRC)—the
  volume of  gas remaining in  the  lungs at
  the resting end-expiratory level
Capacity, total lung (TLC)—the volume of
  gas contained in the lungs at full inspira-
  tion
Capacity,  vital—the  maximum volume of
  gas which can be expired from the lungs
  following a maximum inspiration
Carbonation—conversion into  a carbonate
  (which  in  many cases refers to  one or
  more members of the calcite, dolomite, and
  aragonite groups of minerals) impregna-
  tion with carbon dioxide
Carcinogen—a substance capable of causing
  living tissue to become cancerous
Carcinogenesis—the production  of cancer
Carcinoma—cancer; malignant growth made
  up  of cells derived from epithelial tissue
Carcinoma, bronchogenic—cancer arising in
  bronchial tissue of the lung
Carcinoma, squamous cells—cancer develop-
  ing from squamous epithelial cells
Carcinoma in situ—a neoplastic entity in
  which tumor cells are present but the in-
  vasion of normal tissue has not yet taken
  place
Cardoivascular—pertaining to the heart and
  blood vessels
Cercospora beticola—a member of the genus
  Cercospora,  which  consists of imperfect
  fungi that are  leaf parasites with long
  slender multi-septate spores
Channel black—carbon black made  by im-
  pingement of a luminous natural gas flame
  against  an iron plate from which  it is
  scraped at frequent intervals; properties
  vary widely, but the material has an un-
  usually fine state of subdivision and great
  surface  area
Chloroplast—a specialized body (a  plastid)
  containing chlorophyll in the cytoplasm of
  plants;  the  site of  photosynthesis  and
  starch formation in plants
Cholinesterase—any one of several enzymes
  that hydrolyze  choline esters, occurring
  most frequently  in nervous tissue and the
  blood
Cilium (pi. cilia)—small, hairlike process at-
  tached to a free surface of a cell, capable
  of rhythmic movement
Clearance—the removal of  material from
  the body or from an organ
Clinker—kiln-fired  limestone  from  which
  commercial cement is made
Coalescence—in cloud physics, the merging'
  of two  water drops into a single larger
  drop
       196

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Coefficient, absorption—the  fractional rate
  at which flux density of radiation decreases
  by absorption with respect  to the  thick-
  ness of the absorbing medium traversed
Coefficient, extinction—the  sum  of the ab-
  sorption coefficient and the scattering co-
  efficient for a medium that  both absorbs
  and scatters radiation
Coefficient, scattering—the  fractional rate
  in the transmission of radiation through a
  scattering  medium  (as  of light  through
  fog) at which the flux density of  radia-
  tion decreases by scattering in respect to
  the thickness of the medium traversed
Coh unit—a measure of light absorption by
  particles, defined as that quantity of light
  scattering solids producing an optical den-
  sity of 0.1
Collagen—a  fibrous  protein  forming  the
  main supportive structure of connective
  tissue
Collector, cyclonic—a centrifugal  fraction-
  ator in which a vortex of  air throws par-
  ticles out of a stream, where they  collect
  or stick to the surface of a container
Comminute—to  break  or  crush into small
  pieces
Concentration—the  total  mass  (usually in
  micrograms)  of  the suspended  particles
  contained in a unit volume (usually one
  cubic meter) at a  given temperature and
  pressure;   sometimes, the  concentration
  may be expressed  in terms of total num-
  ber  of  particles  in a unit  volume  (e.g.,
  parts  per  million); concentration may
  also be called the "loading" or the "level"
  of a substance concentration may also per-
  tain to the strength of a solution
Conifer—belonging to the  coniferales order,
  consisting  primarily of  evergreen  trees
  and shrubs
Consolidation—the process  by which a dis-
  eased  lung passes from an  aerated col-
  lapsible state to  one of an airless solid
  consistency because of  accummulation of
  exudate
Contrast—in visual range theory,  the ratio
  of the apparent luminance of a target mi-
  nus that of its background to the apparent
  luminance of the background
Conurbation—a great  aggregation or con-
  tinuous network of urban communities
Coryza—an acute catarrhal condition of the
  nasal mucous membrane with profuse dis-
  charge from the nostrils
Criteria, air quality—a compilation of the
  scientific knowledge of the relationship be-
  tween various concentrations of pollutants
  in the air and their adverse effects
Cryolite—a mineral fluoride consisting  also
  of sodium and aluminum
Cuticle—a varnish-like  layer  covering the
  surface of a leaf
Cytoplasm—the  protoplasm of a  cell  (ex-
  cluding that of the nucleus)
Dead space, anatomic—that part of the air-
  way  occupied by gas  which is  unavail-
  able  (by its location) to take part in oxy-
  gen-carbon  dioxide exchange through the
  walls of the alveoli
Dead space, physiologic—the  volume of gas
  within the alveoli which does not partici-
  pate  in  the  oxygen-carbon  dioxide ex-
  change through the walls of the alveoli
Dehydrogenase—any one of various enzymes
  which accelerate the removal of hydrogen
  from metabolities and its transfer to other
  substances,  thus playing an  important role
  in biological oxidation-reduction processes
Deliquesce—to dissolve gradually  and be-
  come  liquid by  absorbing moisture from
  the air
Density—the amount of matter per unit vol-
  ume,  usually expressed in grams per cubic
  centimeter
Density, optical—the degree  of opacity of
  any translucent medium; the common loga-
  rithm of the ratio of the initial intensity
  of light to the intensity of  transmitted or
  reflected  light
Desorption—the release of a substance which
  has been taken into another substance by
  a physical process or held in concentrated
  form  upon  the  surface of another  sub-
  stance; the reverse of  absorption or ad-
  sorption
Desquamate—to cast off epidermis in shreds
  or scales; to peel off in sheets or scales
Deviation,  standard  geometric   (o-gr)—a
  measuie  of dispersion of values about a
  geometric mean;  the portion of the fre-
  quency distribution that is one standard
  geometric deviation to  either side  of the
                                                                              197

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  geometric mean accounts for 68%  of the
  total samples
Deviation,  standard normal—a measure of
  dispersion of values about a mean value;
  the square  root of the  average of the
  squares of the  individual deviations from
  the mean
Dextran—a  water-soluble   polymer  used
  therapeutically as a plasma substitute
Diameter,  count  median  (CMD)—the geo-
  metric median size of a  distribution of
  particles, based on a numerical count
Diameter,  mass median  (MMD)—the geo-
  metric median size of a distribution of par-
  ticles,  based  upon  a weight  (usually de-
  rived from a  Stokes' Diameter)
Diameter, Stokes'—the diameter that a unit
  density particle of spherical  shape would
  have if it behaved the same as the particle
  being studied
Dichotomous—dividing in  succession into
  pairs;  showing a dual arrangement
Distal—furthest  or  most remote  from the
  median line of the  body, from  the  point
  of attachment,  or from the origin; periph-
  eral (cf. proximal)
Diverticulum (pi. diverticula)—a pouch or
  cul-de-sac of a hollow organ
Dosimetry—the accurate  measurement and
  determination of  (medicinal) doses
Dyspnea—difficult or labored breathing
Earth, diatomaceous—a chalky material used
  as a filter aid, an  absorbent, a filler,  an
  abrasive, and as thermal insulation
Edema—a  condition due to the presence of
  abnormally large amounts of fluid in the
  intercellular  tissue spaces of the body
Effluent—something that flows out, such as
  a liquid  discharged as  a waste
Elution—the process  of washing out, or re-
  moving with the use of  a solvent
Elutriator, fractional—a fractional sampler
  which  removes coarse particles from the
  air by gravity settlement
Emphysema—a swelling due to the presence
  of air,  usually  excess or additional air.
  The term is usually used to  refer to pul-
  monary  emphysema
Emphysema,   pulmonary—a  condition  in
  which there is overdistension of air spaces
  and resultant destruction of alveoli and
  loss of functioning lung tissue
Endocytosis—a condition or disease arising
  from the inclusion within a  cell of ma-
  terial which does not properly belong there
Entomology—zoology dealing only  with in-
  sects
Epidemiology—a science  dealing  with the
  factors  involved  in  the  distribution and
  frequency of a disease process in a popu-
  lation
Epidermis—the outermost  layer of skin in
  animals; any integument
Epiglottis—a plate of cartilage which covers
  the entrance to the larynx during  swal-
  lowing, thus preventing food or fluid from
  entering the windpipe
Epithelium—a  closely  packed sheet of cells
  arranged in one or more layers,  covering
  the surface of the body and lining hollow
  organs
Epithelium, columnar—a type of epithelium
  composed of tall, prismlike cells
Epithelium, spuamous—a type of epithelium
  composed of plate-like cells
Ergometer—an instrument which  measures
  work done, e.g., by muscle contraction; a
  dynamometer
Evaginate—to  turn  inside out or protrude
  by eversion
Extrapolate—to project  data  into  an area
  not known or experienced, and  arrive at
  knowledge based on inferences  of conti-
  nuity of the data
Fibrosis—the  development of fibres tissue;
  sclerosis
Filiform—having the shape of a thread or
  filament
Floe—something  occurring  in  indefinite
  masses or aggregates
Fluorosis—a pathologic condition  resulting
  from excessive intake of fluorine
Fluorspar—the mineral fluorite
Flux—a flowing or discharge of fluid; a sub-
  stance used to promote fusion (as by re-
  moving impurities) of metals or minerals;
  the rate  of transfer of fluid, particles, or
  energy (as radiant energy) across a given
  surface
Fume—an  aerosol formed by the condensa-
  tion of vapors as they cool
Gastric—pertaining  to the stomach
Gastrointestinal—pertaining to  the stomach
  and intestines
       198

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Goblet cell—a type of epithelial cell contain-
  ing mucus and having the shape of a flask
  or goblet
Gravimetric—of or relating to measurement
  by weight
Haze—fine dust  or  salt particles dispersed
  through a  portion of the atmosphere;  the
  particles are so small that they cannot be
  felt  or individually  seen with the naked
  eye,  but they diminish horizontal visibil-
  ity  and give the atmosphere a character-
  istic opalescent appearance that subdues
  all colors
Hematite—the mineral iron  oxide; Fe2O3
Histamine—a substance which produces di-
  latation of capillaries and  stimulates gas-
  tric secretion, occurring in both animal and
  vegetable tissues; /3-imidazolethylamine
Histogram—a  graphical  representation  us-
  ing a series of bars
Histology—the study of the anatomy of  tis-
  sues and their microscopic cellular struc-
  ture
Hydrocarbon—a  compound containing only
  hydrogen and carbon.  This group is sub-
  divided into alicyclic, aliphatic, and aro-
  matic  hydrocarbons  according to  the  ar-
  rangement of the atoms and the chemical
  properties of the compounds.
Hygroscopic—readily absorbing and retain-
  ing moisture from the atmosphere
Hyperplasia   (adj.  hyperplastic)—an  in-
  crease in the number of cells in and bulk
  of a tissue, with retention in  normal func-
  tion and cellular structure
Illumination—the process  in which  light is
  brought to some  surface  or object
Impactor,  cascade—an  instrument  which
  employs several  impactions  in series to
  collect successively smaller sizes  of par-
  ticles
Incidence—the rate at  which a  certain event
  or disease occurs
Insolation—the rate at which direct solar ra-
  diation (of all wavelengths)  is delivered
  to a unit area of a horizontal surface,  us-
  ually at or near ground level
Insulation—the prevention of  the transfer
  of energy between two conductors by sepa-
  ration  of the conductors with  a non-con-
  ducting material;  or, the  non-conducting
  material itself
Interstitial—pertaining to or situated in the
  space between cells
In vitro—in a test  tube or other artificial
  environment
In vivo—within a living body
Isotherm—a line  on a  chart representing
  changes of volume or pressure under con-
  ditions of constant temperature; or lines
  on  a map connecting points having  the
  same temperature
Ketone—any of a class of organic compounds
  that are characterized by a carbonyl group
  attached to two carbon atoms, usually con-
  tained in hydrocarbon radicals or in a
  single bivalent  radical,  similar to  alde-
  hydes but less reactive
Lacrimation  (lachrymation)—tear forma-
  tion, especially in excess
Langley—a  unit of energy per unit  area,
  commonly employed  in  radiation theory
  and equal to one gram-calorie per square
  centimeter
Larynx—the organ concerned with the pro-
  duction of the voice, situated at the upper
  end of the trachea
Lesion—an  injury or  other  circumscribed
  pathologic change in a tissue
Logarithm—a number which represents the
  power to  which a given number must be
  raised to  produce another  given number
Lumen—the inner space of a hollow organ
  or tube
Lycopodium—a genus of club-moss; a pow-
  der  ("vegetable sulfur")  used to prevent
  the  agglutination  of  pills in a box  or as
  a dusting  powder
Lymph—a fluid that is collected from  the
  tissues throughout the body, flows in  the
  lymphatic vessels, and is eventually added
  to the bloodstream
Lymphoma—any neoplasm developing from
  lymphatic tissue
Macrophage—a large phagocytic cell found
  in the connective tissue, especially in  areas
  of inflammation
Malignancy—something which tends to  be-
  come progressively  worse  and  if  un-
  checked could result in death
Mastoiditis—an  inflammation of  the  skull
  bone behind the ear
Mean, geometric  (M,)—a  measure of cen-
  tral tendency for a log-normal distribution;
                                                                             199

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  the value, in a given set of samples, above
  which 5Qc/c  of the values lie
Meatus—a natural body passage, particular-
  ly the external opening of a canal
Mesothelioma—a tumor which develops from
  the lining of a coelomic body cavity
Metaplasia (adj. metaplastic)—a change in
  the cells of a tissue to a form which is not
  normal for that tissue
Metastable—marked only by a slight margin
  of stability
Meteorological range  (standard  visibility,
  standard  visual  range)—an  empirically
  consistent measure of the visual range of
  a target; a concept developed to eliminate
  from consideration the threshold contrast
  and  adaptation luminance, both of which
  vary from observer to observer
Morbidity—the occurrence of a disease state
Morphology—a branch of  biology  dealing
  with the structure and form of  living or-
  ganisms
Mortality—the ratio of the total number of
  deaths to the total population, or the ratio
  of the number of deaths from a given dis-
  ease to the total number of people having
  that disease
Motion,  Brownian—the rapid  random mo-
  tion  of small  particles due  to  bombard-
  ment by surrounding molecules which are
  in thermal motion
Mucin—a glycoprotein  or mucopolysaccha-
  ride  secreted by mucous glandular cells
Mucopurulent—pertaining to an exudate (or
  sputum) that is chiefly purulent  (pus)  but
  also contains significant amounts of mucus
Mucoviscidosis—cystic fibrosis
Mucus  (adj. mucous)—the clear viscid se-
  cretion of a mucous membrane
Mural—pertaining  to the wall  of a cavity
Mustard gas—an irritating and toxic volatile
  liquid  used  as a weapon in World War I;
  dichloroethyl sulfide
Naris  (pi. nares)—a nostril or other open-
  ing into the nasal cavity
Nasopharynx—the  part  of  the  pharynx
  (throat) lying above the level of the soft
  palate
Nebulize—to reduce to a fine spray
Necrosis—localized death of cells
Neoplasm—any abnormal  growth, such  as
  a tumor
Nephelometer—a  photometric  instrument
  for the determination of the amount of
  light  transmitted  or  scattered by a  sus-
  pension of particles
Node—a circumscribed swelling
Node, lymph—one of many accumulations of
  lymphatic  tissue  situated throughout the
  body
Nomogram—a  graph  that enables  one to
  read off the value  of a dependent variable
  with the use of a straightedge,  when the
  values of two or  more independent vari-
  ables are known
Nucleation—the process of particle  growth
  through collection  around a nucleus
Nucleus  (condensation nucleus)—a particle
  in the size range  from  O.!/* to  I/* which
  serves as a nidus on which water or other
  vapors in  the  air can condense to  form
  liquid droplets
Olefin—a class of unsaturated aliphatic hy-
  drocarbons of the general formula CnH2n
Olfactory—pertaining to the sense of  smell
Ophthalmic—pertaining  to the  eye
Otitis—an inflammation of the ear
Palisade  tissue—a  layer  of  columnar cells
  rich in chloroplasts found beneath the up-
  per epidermis of foliage leaves
Parameter—an  arbitrary constant  which
  characterizes a mathematical expression
Parenchyma—the specific or functional tis-
  sue of a gland or organ, as opposed to its
  supporting framework
Particle—any dispersed matter, solid or liq-
  uid,  in which  the individual aggregates
  are larger than  single small  molecules
  (about 0.0002/j, in diameter), but  smaller
  than about BOOju  in  diameter
Particulate—existing in the form of minute
  separate particles
Pathogenesis—the production or  the mode
  of origin  and  development of  a  disease
  condition
Pathology—the study of the essential nature
  of disease, particularly with respect to the
  structural  and functional  changes in  or-
  gans and tissues
Peritoneum—the membrane  lining the  ab-
  dominal cavity and  investing the viscera
Phagocyte—a cell that has the power of in-
  gesting microorganisms and  other small
  particles
       200

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Phagocytosis—the ingestion of a  microor-
  ganism or other small particle by a phago-
  cyte
Pharynx—the upper expanded portion of the
  alimentary canal lying between the mouth,
  the nasal cavities, and the beginning of
  the esophagus; the throat
Photometer—an  instrument for measuring
  luminous intensity, luminous  flux, illumi-
  nation, or brightness by comparison of two
  unequal lights  from different  sources
Photomicrograph—a photograph of a  mag-
  nified image of a small object
Photosynthesis—the formation  of  carbohy-
  drate from carbon dioxide and water in
  the presence of chlorophyll and light, in
  plant tissues
Physiology—a  science  which  studies the
  function of a living organism or its  parts
Phytotoxic—harmful to plant materials
Plasmolysis—the shrinking of the cytoplasm
  away from the wall of a living cell due to
  water loss by osmotic action
Plethysmograph—an apparatus  for the de-
  termination and recording of  a change in
  the size of an organ or limb or body
Pneumococcus  (pi. pneumococci)—a bacte-
  rial organism which most often infects the
  lung and is a common cause of pneumonia;
  Diplococais pneumoniae
Pneumoconiosis—a fibrous  reaction in the
  lungs, caused by the retention of certain
  inhaled dusts in the lungs
Pneumonitis—a general term for inflamma-
  tion of the  lung
Pneumotachygraph—an instrument used to
  determine  the  force  and  velocity of re-
  spired air
Polystyrene—a clear,  colorless  polymer of
  styrene,  an unsaturated  hydrocarbon of
  theformC6H5CH = CH,
Potentiation—synergism,  as  between  two
  agents which together have a greater ef-
  fect than the sum of their effects  when
  acting separately
Precipitation—any  or  all of the  forms of
  water  particles, whether liquid or  solid,
  that fall from  the atmosphere and reach
  the ground. It is a major class  of hydro-
  meteor, but is distinguished from cloud,
  fog, dew, rime, frost, etc. in that it  must
  "fall," and is also distinguished from  cloud
  and virga in that it must reach the ground
Precipitator, electrostatic—an apparatus for
  the removal of  suspended particles from
  a gas by charging the particles and pre-
  cipitating them by applying a strong elec-
  tric field
Predator—an organism living by preying on
  other organisms
Prevalence—the number of cases of a dis-
  ease at a given time
Prodrome—the symptoms preceding the ap-
  pearance or recognition  of  an actual dis-
  ease state
Proteinosis—-the accumulation of protein in
  excess in the tissues
Proteinosis, alveolar—a chronic progressive
  lung disease characterized by the accumu-
  lation of granular proteinaceous material
  in the alveoli
Proximal—nearest to the center of the body
  or the point of origin (cf. distal)
Radioautograph  (autoradiogram)—a radio-
  graphic portrayal of an object or organism
  made by the inherent radioactivity of the
  object or organism
Rale—an abnormal respiratory sound heard
  in auscultation of the chest
Ratio, standardized  mortality—-the ratio of
  the number of deaths observed in a given
  population over  a given period of time to
  the number of  deaths expected to occur
  in the given population over the same pe-
  riod of time if  the given  population be-
  haved as any other group of similar com-
  position  would during that same  period
Reflectometer-—a photometric or  electronic
  device  for measuring the  reflectances of
  light or other  radiant energy
Regression—a trend or shift toward a mean.
  A regression curve or line is thus one that
  best fits a particular set of data according
  to some principle
Rhinitis—an inflammation  of the nasal mu-
  cous membrane
Rhinorrhea—"runny nose"
Rhonchus (pi. rhonchi)—a dry, coarse sound
  usually originating from partial obstruc-
  tion in a bronchial tube
Scattering, Mie—any scattering produced by
  spherical particles, without specific regard
  to the comparative size of radiation wave-
  length or particle diameter
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Scattering, Rayleigh—any scattering  proc-
  ess produced by spherical particles whose
  radii are smaller than about one-tenth the
  wavelength of the scattered radiation
Sigmoid  curve—a "bell-shaped" curve serv-
  ing as a prototype for  the normal distri-
  bution of data  about a mean
Silicosis—a type  of pneumoconiosis caused
  by inhalation of silica dust and character-
  ized by  silica-containing nodules  of scar
  tissue in the lung parenchyma
Sorption—the generalized term for the many
  phenomena commonly included under the
  terms adsorption and absorption, when the
  nature of the phenomenon is unknown or
  indefinite
Spirometer—an instrument for the measure-
  ment of the volume of gas respired by the
  lungs
Spore—a  reproductive  element  of  many
  lower organisms
Squamous—resembling  or  covered  with
  scales
Standards, air  quality—levels of air pollut-
  ants which cannot legally be exceeded dur-
  ing a specific time in a  specific geographi-
  cal area
Stasis—the slowing down or cessation  of the
  normal flow
Stigma—the  part of the pistil of  a flower
  which  receives  the pollen granules and on
  which  they germinate
Stokes' Law—a law in physics stating that
  the  force  required  to move  a  sphere
  through a given viscous fluid at a low uni-
  form velocity is directly proportional to
  the velocity and radius of the sphere
Stoma (pi. stomata)—a small opening in the
  epidermis of a plant
Subcutaneous—beneath the skin
Supercool—to cool below the freezing point
  without  solidification or crystallization
Supersaturation—a condition of containing
  an  excess of some material or force, over
  the  amount required for saturation nor-
  mally
Synergism—a situation in which the com-
  bined action of two  or more agents acting
  together is greater than the sum of the
  action of these agents  separately
Systemic—relating to the body as a whole,
  rather than to its individual parts
Tannin—any one of a group of soluble as-
  tringent complex phenolic substances that
  are widely distributed in plants
Terpene—any one of a class of isomeric hy-
  drocarbons of  the prototype C10H16  that
  are found in many essential oils, but espe-
  cially from conifers; may also refer to any
  of various compounds derived from ter-
  pene hydrocarbons or closely  related to
  them
Tipburn—a disease of the potato, lettuce, and
  other cultivated plants, characterized by
  burning or browning of the tips and mar-
  gins of the leaflets and caused by loss of
  water due to excessive heat and sunshine
Toxicology—the study of poisons, including
  their  preparation, identification,  physio-
  logic action, and antidotes
Trachea—windpipe; the airway extending
  from the larynx to the origin of the two
  mainstem bronchi
Tracheobronchitis—an inflammation of  the
  trachea and bronchi
Turbidity—in meteorology, any condition in
  the atmosphere which reduces  its trans-
  parency to radiation, especially to visible
  radiation
Tyndallometer—an instrument  that meas-
  ures suspended particle concentration by
  the amount of light scattered  out of a
  beam
Ultrafilterable—capable of being  separated
  by  a  dense filter which is used  for  the
  filtration  of  a colloidal  solution  holding
  back the  dispersed particles but  not the
  liquid
Updraft—an upward movement of air or
  other gas
Ventilation,  minute—the total volume of gas
  respired in one minute, i.e., the tidal vol-
  ume multiplied by breaths per minute
Visibility—In United States weather observ-
  ing practice,  the greatest distance  in a
  given direction at which it is just possible
  to see and identify with the unaided eye
  (a) in the daytime, a prominent dark ob-
  ject against the sky  at the  horizon, and
  (b)  at night, a known,  preferably unfo-
  cused,   moderately intense light  source.
  After  visibilities  have been determined
  around the entire horizon circle, they are
       202

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  resolved into a single value of prevailing
  visibility for reporting purposes.
Visual range—the distance, under daylight
  conditions, at which the apparent contrast
  between the  specified type of target and
  its background becomes just equal to the
  threshold  contrast of an  observer; to be
  distinguished from the night visual range.
  The visual range is a function of the at-
  mospheric  extinction coefficient, the albe-
  do and visual angle of the target, and the
  observer's threshold contrast at the mo-
  ment of observation.
Volume, forced expiratory  (FEV)—the vol-
  ume of  gas  forcibly exhaled over a given
  time interval (usually  measured in sec-
  onds)  after maximum  inspiration,  e.g.,
  FEVi.o  for  this measurement  over  a 1.0
  second period.
Volume, minute—same as minute ventilation
Volume, tidal—the volume of gas  inspired or
  expired during each  respiratory cycle.
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                                    AUTHOR  INDEX
Ackley, C., 94
Agnese, G., 162, 172-173
Ahlquist, N. C., 56, 57, 59
Albert, R. E., 122
Alcocer, A. E., 26
Altshuler, B., 113,  117, 118
Amberg, H. R., 106
Amdur, M. O., 113, 131,  132,  133,
  134, 136
Andersen, A. A., 17, 19
Anderson, D. O., 150, 161, 164, 165,
  173-174
Anderson, P. J., 92
Andrea, J., 140
Angel, J. H., 168,  175
Angstrom,  A. K., 38, 39, 43, 53
Antler, M., 69
Antweiler,  H., 121
Arnett, L.  C., 122
Ashworth.  J. R., 41, 44
Auerbach,  0., 141
Axt, C. J.,  19
Ayer, H. E.,  137

Baetjer, A. M., 132
Balzer, J. L., 137
Barfinkel, L., 141
Barlett, F. E., 106
•Bates. D. V., 163, 173-174
Baulch, D. M., 19,  37
Baumberger, J. P., 117
Bechmann, H., 117
Becker, W. H., 165, 173-174
Belton, J.,  154
Berge, H.,  94
Biersteker, K., 168, 175
Black, S., 118
Blifford, I. H., 11
Bohne, H., 91, 92,  94
Bonser, G. M., 139
Boren, H.  C., 135
Bowden, A. T., 26
Bownes, K., 105
Bradley, W., 152,  154, 156, 171, 172
Brandt, P., 17
Brasser, L. J., 150, 153, 158
Braverman,  M. M., 153, 154, 171
Brieger, H.,  122
Brier, G. W., 41
Briscoe, W., 122
Brooke, A. G. F.,  71
Brown, C.  E., 117
Brown, D. A., 157, 172
Brown, J. H., 118
Brown, M. C., 137
Bryson, R. A., 42, 43
Buck, S. F.,  157, 172
Bunyard,  F. L., 99
Burgess, F., 130, 131, 136
Burgess, S. E., 151, 171
Burn, J. L., 157, 158, 159, 164, 172-
  173, 174
Bye, W. E.,  167

Cadle, R. D., 8, 10
Cambell, J. A., 137
Capps, R., 135
Carey, W. F., 69
Games, W. H., 141
Cartwright, J., 69, 71
Casarett,  L. J., 122. 123
Cassel, E. G., 150, 154,  156, 171, 172
Cefls, F., 139
Chaney, A. L., 26
Changnon, S. A., Jr., 41
Charlson,  R. J., 19, 54,  55, 56, 57, 59
Chass, R.  L., 24
Christofano, E. E.,  135, 136
Clark, J. G., 22
Clark, W. E., 23, 54
Clemo, G. R., 137
Coblentz,  H., 39
Coffin, D. L., 129
Collet, A., 123
Collins, G. F.,  106
Conner, W.  D., 53
Cook, K. M., 118
Cooley, R. N.,  132
Cooper, W.  C., 137
Copson, H. R., 66, 67, 68,  69
Corn, M., 6, 8, 19, 132, 133
Coughanower, D. R., 136
Cralley, L. J., 137
Creasia, D.  A., 133
Crider, W. L., 26
Crowley, D., 154,155
Cuffe, S. T., 5
Cullumbine, H., 130, 132,  136
Czaja, A. T., 91, 92

Dalhamn, T., 121, 122, 135
Barley, E. F., 90, 91, 92, 93
Dautrebande, L., 117, 119, 133, 135
Davies, C.  N., Ill, 117, 118,  119,
   121, 122, 123, 132, 135, 136
Davies, R. I., 157, 171-172
Day, J. A., 11
De Groot, I., 99, 101
Delly, J. G., 18
De Maio, L., 19
Dennis, W. L., 118
Dessens, J., 18
De Treville, R. T., 135
Devir,  S. E., 131
Diamond, J. R., 149, 155, 156, 171,
  172
Dickerson,  R. C., 20, 22
Diem,  M., 17
Djordjevic, N., 11
Dobrogorski,  0.  J., 130
Dohan, F. C., 164
Doherty, R. E., 26
Douglas, J. W. B., 165, 173-174
Downs, W. L., 122
Draftz, R. G., 18
Draper, P., 26
Drinker, P., 8, 113, 117, 118, 132
Drolette, B. M., 153, 154, 171
Du Bois, A. D., 133

Eckel,  O., 39
Edmonds, S. M., 106
Elliott, A., 166
Ellis. O. B., 66, 67, 68
Ellison. J.  M.. 22
Epstein, S. S., 140
Erdhardt, C., 153, 154, 171


Falk, H. L., 120, 134, 137,138,141
Faoro, R. B., 16
Faulds, J. S.. 139
Fensterstock, J. C., 16
Ferris. B. G., Jr.,  164, 173-174
Field,  F., 153, 154, 171
Fieldner, A. C., 117
Findeisen, W., 114, 115, 119
Finn, J. L., 117
Firket, J.,  150
Fischer, W. H.,  19
Fish, B. R., 10
Fisher, M., 121
Flesch, J., 132
Fletcher, C. M.,  168, 175
Fochtman, E. C., 71
Foster, K.  E., 17
Frank, E. R.,  20, 23
Frederick, R.  H., 41
Friedlander,  S. K., 54, 58
        204

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Gates, D. M., 38
Georgii, H. W., 41
Gibb, F. R., 117, 119, 121
Gilbert, J., 69
Giles, C. H.,  69
Giner, R., 40
Girorer, W., 117
Glasser, M.,  154, 155
Goetz, A., 6,  10, 19, 58, 59,, 106
Gong, W. K., 26
Gore, A. T.,  151, 171
Graf, P., 132
Graff-Baker, C., 71
Greenburg, L., 68. 69, 153, 154, 171
Greenwood,  D. A.. 95
Greenwood, J. A., 69
Greezuitay, L. A., 139
Gross, P.. Ill, 123, 135
Grote. M. J., 139
Gruber, C. W., 17
Gucker, F. T., 19
Guderian, R., 92
Haddow, A., 139
Hagstrom, R. M., 159, 161, 172-173
Haines, G. F., Jr., 20
Hamilton. R. J., 17
Hammond, C., 130
Hammond, E. C.. 141
Hand, I. F., 40
Handyside, A. J., 166, 168, 174-175
Harris, J., 69
Harris, W. B., 17
Harrison, L. E., 95
Hatch, T. F., 8, 111,  119, 120, 123
Haythorn, S. R., 131
Helwig, H. L., 26
Hemeon, W. C. L., 17, 20
Hendrix, W. G.,  23
Hess, V. F., 40
Hewson, E. W., 17
Hilding, A. C., 122
Hill, A. C., 93, 94
Hill, I. D., 148, 168, 175
Hitchcock, A. E., 93,  94
Hodkinson, J. R., 53
Hoffman, P., 19
Holbrow, G. L., 71
Holden, F. R., 95
Holland, W. W., 162, 163, 166, 167,
  172-173, 174-175
Holma, B., 122
Holzworth, G. C., 51
Horning, E. S., 139
Horton, R. J. M., 164
Horvath, H., 19, 54, 56, 57, 59
Hudson, J. D., 66, 67
Hueper, W. C., 137
Huey, N., 81
Humphreys, W. J., 43
Kurd, F. K., 23
Ide, H. M., 20
Imada, M., 57

Jacobs, M. B., 65, 69, 153,154,171
Jacobson, J. S., 93, 94
Jennings, 0. E., 94
Jens, W., 24, 25
Johnstone, H. F., 136
Jones, E. E., 26
Joosting, P. E., 151, 153, 158
Joshi, S., 140
Junge, C. E., 11, 23, 53, 54
Jurksch. G., 17
Jutze, G. A.. 17

Kaiser, E.  R., 25, 107
Kakis, F., 105
Kallai, T.,  58, 59
Kanitz, S., 162, 172-173
Katz, M., 17, 22
Keagy, D. M., 21
Keenan,  R. G., 137
Kemeny. E.,  21
Kemnitz, D. A.,  5
Kenrick, G. W., 39
Kerka, W.  F., 107
Klarman, H. E., 84
Kline, D. B., 41
Knowelden, J., 166, 168, 174-175
Kolb, L.  H., 139
Kolesnichenko, T. S., 139
Korff. F., 39
Kotin, P., 120, 132, 136, 137, 138,
  141
Krahl, V.E., 111
Kramer. G. D.. 21, 22
Kreichelt, T. E., 5
Kuepel, R. E., 138
Kurland, L. T., 156
Kuschner, M., 140

La Belle, C. W.,  135, 136
Lainhart, W. S., 137
La Mer, V. W., 118
Landahl, H.  D.,  114, 118
Landau, E.,  159, 162, 164, 172-174
Landsberg, H., 38, 39, 40, 41
Langer,  G., 71
Larrabee, C. P., 66, 67, 68, 69
Lawther, P. J., 153, 168, 169, 171,
  175
Le Clerc, E., 69, 81
Lee, G.,  113
Lee, R. E., Jr., 19, 26
Lehmann,  C., 118
Lehmann,  K., 117
Lemke, E. E., 12
Leonard, A. G.. 154, 155
Linnell,  R. H., 105
Lippmann, M., 17, 122
Lloyd, T. C., 167
Lodge, J. P., 19, 20, 23
Long, J. E., 135, 136
Ludwig, F. L., 19
Ludwig, J. H., 42, 43
Lunn, J. E., 166
Lynch, J. R., 137

Mac Phee, R. D., 26
Magill, P. L., 95
Mantel, N., 140
Manzhenko, E. G., 167, 174.-175
Marcus, S. C., 167
Mark, H.  L., 106
Markul, I., 138
Markush,  R. E., 157
Martin, A. E.( 152, 153,  156, 171-
  172
Mateer, C. L., 40
McCaldin, R. O., 167
McCarroll, J., 150, 154,  156, 171-
  172
McConnell, W. J., 117
McCormick, R. A., 19, 37, 38, 42,
  43
McCrone, W. C., 18
McCune, D. C., 93, 94
McDermott, M., 133
McKee, H. C., 105
McMullen, T. B., 16
McNerney, J., 119
Meeker, G. O., 11
Meetham, A. R., 40, 41
Megaw, W. J., 23
Meller, H.  B., 69, 71
Metnieks, A. L., 23
Michelson, I.,  81
Middleton, W. E. K., 51, 52
Mie, G.. 10, 55
Miller, A., 135
Miller, E. C., 137
Miller, P. M.,  94
Miller, W. S., Ill
Milley, P. S., 123
Miner, M. L., 95
Mitchell, J. M., Jr., 43
Mitchell, R. I., Ill
Moll, A. J., 136
Morrow, J., 105
Morrow. P. E., 111. 118, 119,121
Mountain, I. M., 150, 156, 171-172
Mountain,  J. D., 149,  156, 171-172
Mueller, P. K., 26, 57

Nadel, J. A., 17, 132
Nader, J.  S., 19
Nagelschmidt, G., 69
Nau, C. A., 132
Neal, J., 132
Nelson, N., 113, 117, 118, 122
Neuberger, H., 40
Ney, F. G., 118
Noll, K. E., 55, 57
Nussbaum, R., 92
                                                                                              205

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O'Connor, J. J., Jr., 81
O'Konski, C. T., 19
Orr, C., 23
Ortiz, H., 39
Ott, R. R., 105
Owens, J. S., 117
Ozolins, G., 12

Paccagnella,  B., 167, 174-175
Pack, M. R., 93, 94
Pajenkamp, H., 92, 93
Palm, P. E.,  119
Palmes, E. D., 113, 117
Parish, S. B., 89
Park, J. C., 21
Parker, A., 71
Pascua, M., 137
Pate, J. B., 19
Patterson, H. S., 117
Patterson, R. K., 19, 26
Pattle, R. E., 130, 131, 136
Paulus, H. J., 154
Pavanello, R., 167,  174-175
Payne, W. W.,  138
Peirce, G. J., 89,  91
Pemberton, J., 157, 158, 159, 164,
  172-174
Pesarin, F., 167, 174-175
Peterson, C.  M., 54
Peterson, J. T., 43
Petrie, T. C., 72
Petrilli, F. L., 162, 172-173
Pfltzer, E. A., 123
Phillips, P.  H., 95
Pickard, H. B., 19
Pilat, M. J.,  54, 56
Pitts, J. N., Jr., 19
Plotkin, T., 113
Policard, A., 123
Pollack, L. W., 23
Potter, J. G., 41
Pregermain, S., 123
Preining, 0., 11, 58, 59
Preston, R., St. J.,  66, 69
Prindle, R. A., 164, 167, 173-174
Przemeck, E., 93
Pueschel, R. F., 10, 19, 54, 55, re,
   59
Purvance, W. T., 23
Pybus, F. C., 137
Pylev, L. N., 139

Quebedeaux, W. A., 105

Raymond, V., 92
Reed, J. I., 153, 154, 171
Rees, W. H., 71 ,72
Rehm, F. R., 24, 25
Reid, D. D.,  162, 163,  165, 167, 172-
   173, 174-175
Reid, L., 135
Rich, S., 94
Rich, T. A., 23
Ridker, R. G., 84
Rinehart, W. E., 135
Robbins,  R.  C., 10
Robison,  C. B., 101
Robinson, E., 19, 51, 52, 53, 58
Robinson, N., 38
Robson, C. D., 17
Roderick, W. R., 105
Roesler, J. R., 19
Ronald, G.,  18
Rose, A.  H., 24
Rossano, A. T., 105
Rowling, H., 26

Saffiotti,  U., 139
Saito, Y., 117
Salem, H., 130, 132, 136
Samuels, S. W., 99, 101
Sanderson, H. P., 15, 22
Sanyal, B.,  66, 69
Sauberer, F., 39
Sawicki, E., 138, 140
Sawyers, L. A., 113
Sayers, R. R., 117
Scheffer, F., 93
Schilling, F. J., 165, 173-174
Schnurer, L.,  131
Schonbeck,  H., 92
Schrader, J. H., 39
Schrenk, H. H., 134
Schueneman, J. J.,  101
Schusky, J., 99
Scott, J.  A., 152, 171
Scott, W. E., 105
Selikoff,  I. J., 130
Seltser, R., 162, 163, 167, 172-173,
  174-175
Sensenbaugh, J. D., 17
Seriff, N. S., 153, 171
Shabad,  L. M., 139
Shaddick, C. W.. 151, 171
Shaffer,  N. R., 12
Shaver, J., 135
Sheesley, D., 11
Shelden, J. M., 17
Sheleikhovskii, G. V., 37, 38, 39
Sheppard, P. A., 37
Shubik, P., 139
Shupe, J. L., 95
Sievers,  F.  J., 94
Silverman, L., 23, 113
Sisson, L. B., 69, 71
Skidmore, J. W., 69
Slater, R. W., 17
Smith, B. M., 10
Smith, R., 16
Smith, W. S., 27, 101
Speizer, F. E., 168, 175
Spiegelman, J., 122
Sprague, H. A., 159, 161, 172-173
Spurny, K., 20
Stagg, J. M., 39, 40
Stalker, W. W., 20, 22, 101
Stanley, T.,  138
Steiner, P. E., 138
Steinhauser, F.,  39
Steinhubel, G., 91
Shembridge, V.,  132
Stern, A. C., 19,  51, 52, 53, 58, 72
Stevenson, H. J. R., 19
Stewart, M. J., 139
Stocks, P., 157, 171-172
Stoeber, W., 17
Stokinger, H. E., 129, 130, 134
Stone, R. W., 162,  163, 167, 172-
  173, 174-175
Stout, A. P., 141
Stout, G. E., 42
Stratmann,  H., 93
Strauss, W., 23
Strethlow, C., 122
Sullivan, J.  L., 22
Sutton, O. G., 106
Swartetrauber, P., 19
Tabershaw, I. R., 137
Tabor, E. C., 71, 72, 139, 140
Taylor, J. R., 26
Tebbens, B. D., 72
Telford, J. W., 42
Thomas, B. G. H., 117
Thomas, M. D., 93, 94
Thompson, R. M., 117
Tice, E. A., 65, 71
Tinker, C. M., 168, 176
Tomashefski, J. F., 112
Tourangeau, F. J., 118
Tourin, B., 81
Toyama, T., 162,  167, 172-173, 174-
   175
Tracewell, T. N., 118
Transtrum, L. C., 93, 94
Tremer, H., 132,  136
Tufts, B. J., 23
Turk, A., 105, 106
 Uhlig, H. H., 80
 Underbill, D. W., 132, 136
 Upham, J. B., 68
 Valko, P., 43
 Van Haut, H., 193
 Van Wijk, A. M., 117
 Venezia, R., 12
 Verma, M. P., 165, 173-174
 Vernon, W. H. J., 65
 Verssen, J. A., 12
 Vintinner, F. J., 132
 Volz, F., 19, 37, 43
 Von Zuilen, D., 150, 153, 158
 Vorwald, A. J., 134
         206

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Wagman, J., 10, 19, 26               Weinstein, L. H., 93, 94               Wohlers, H. C., 106
Wagner, W. D., 130                  Weisbrod,  B. A., 84                   Wolfson, P., 122
Walkenhorst, W., 117, 119            Went, F. W., 53                      Wright, G. W., 167
Waller, R. E., 71, 165, 169, 173-174   Wentzel, K. F., 92                    Wynder, E. L., 19
Walter, E.  W., 150,  156,  171-172   West, P. W., 19                      Yancey A  R  113
Walther, J.  E., 106                  Whitby, K. T., 23                    Yant  W P  117
Walton, W.  H., 17                   Wicken, A. J., 162                    Yarmus ' L.," 113, 117, 118
Wang, C.  S., 54, 58                   Williams, J. D., 99                    Yocom J E 69 71
Warren, W. V.. 71, 72                Williamson, J. B. P., 69                    ' '  "   '
Watanabe, H., 154, 167, 171, 174-     Wilms, W., 93                        Zeidberg, L. D., 101, 156, 159, 161.
  175                               Wilson, I. B., 118                       164,  172-173, 173-174
Wedd, C.  D., 131                    Winkelstein, W., 158, 172-173         Zickmantel, R., 64, 173-174
Weibel, E. W.,  114                   Wiseley, D. V., 137                    Zwi, S., 132
                                                                                              207

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                                          SUBJECT INDEX
Acrolein toxicity, 135, 136
Adhesion properties, 8-9
Adhesive dustfall collectors, 17
Adsorbed substances
  discussion of, 130
Adsorption
  role in odors, 107
  role in toxicity, 130
Aerodynamic factors
  respiratory tract, 113-114, 115-
    116
Aerosols
  pulmonary effects, 131-137
  reduction of  toxicity, 130-131
  toxicity, 129
Age
  relationship  to mortality,  148,
    161, 158, 160
Air pollution episodes, 15, 150-154
Alveolar deposition,  119
Ammonia toxicity, 122, 135
Animal odors, 107
Aromatic hydrocarbons as carcino-
  gens, 137-141
Asbestos
  toxicity of, 129-130, 150
Automobile exhaust emissions, 26
Automobiles
  corrosion of, 71
                B

Beryllium
  toxicity of, 129-130, 150
Birmingham, Alabama
  public opinion survey, 101
Bronchitis
  morbidity studies of,  156, 161-
    169
  mortality studies  of, 150-154,
    156-161
Brownian motion, 9,113
Buffalo,  New York
  mortality studies, 158, 160, 161,
    170, 171
  public opinion survey, 101
Building materials
  deterioration of, 69
Buildings
  deterioration, 73-74
Canada
  morbidity studies, 163, 164, 173
Cancer
  lung, 137, 141, 157-162
  mortality, 157, 160-162
  stomach, 158, 161-162
Carbon black
 toxicity of, 132
Carbon particles
  toxicity, 135
Carcinogenic hydrocarbons, 137-
  142
Carcinogens
  discussion of, 137-142
Cascade impactors, 17, 19
Cement plants
  emissions from, 24, 25-26
Cement-kiln dust, 89-93
Channel black  effects resp. tract,
  132
Chemicals
  odors from, 107
Chicago mortality  studies. 150
Children
  morbidity studies, 165-167
Chlorides
  corrosive effects, 71
Clearance model
  respiratory system, 120-121
Clearance of particulate  matter in
  the respiratory system, 121-123
Climate
  effects of particulate on, 35, 42-
    44
Climatic change
  world-wide, 42-44
Coal combustion
  effects of smoke on animals, 131-
    132
  emission from, 24, 27
Coal combustion gases
  corrosive effects, 69-70
Coal dust
  deposition, 117
  physiological effects of, 133
Combustible waste odors, 107
Combustion odors, 107
Combustion products
  corrosive effects, 69-70
Computer techniques of  sampling,
  19
Copper alloys
  corrosion of, 68—69
Corn oil particles
  deposition, 118
Corrosion of metals, 65-69, 72-74
Costs of air pollution damage, 79—
  84
Cotton
  soiling and deterioration of, 72,
    74
Crust formation on plants, 89-93
Cyclonic collectors, 17

                D
Deposition
  respiratory system, 112-119
Deposition (dust)  on vegetation,
  89-96
Desorption
  odorants, 106-108
Deterioration of materials, 65-74
Detroit
  mortality studies, 150, 154, 171
Diurnal variation
  particulate, 40, 41
Dublin,  Ireland
  mortality study,  154,  155
Dust
  corrosive effects, 65-74
  effects   on  resp. tract,  112-119
  effect on textiles, 71-72, 74
Dust components,  92-93
Dust mineral
  deposition, 117
Dustfall
  description of, 11, 16-17
  seasonal variation, 39
  typical  urban values,  17
Dustfall collectors, 17-19
Dustfall jars, 17
                E
Economic effects, 79-85
Economical level
  relationship to mortality, 156-
    158, 159-162, 163, 164, 167,
    170, 176
Electrical instruments
  corrosion of, 69
Electron microscopy, 20, 23
Elutriators, 17
Emission  factors, 24
Emission  inventories, 12
        208

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England
  morbidity studies, 154-156,161,
    162, 163, 164-169, 171-176
  mortality studies, 150-153,  154,
    156-159, 171-176
Epidemiological studies, 150-154
Exacerbation of chronic diseases,
  148-149, 154-156, 161-176
Extinction
  dependence on particle size, 55
Ferric sulfate
  toxicity, 132-133
Filters
  sampling, 20-22
Fluorides
  effects on vegetation, 93-94
Fluorosis
  animal, 95
Fog
  correlation with mortality, 150-
    153
Food odors, 107
Formaldehyde
  toxicity, 122, 135, 136
Foundry
  odors from, 107
Foundry dust
  effects on vegetation, 94
France
  economic effects of air pollution
    in, 81
Fuel  oil combustion
  emissions from, 24
                G
Gas and particulate mixtures
  synergistic  pulmonary effects,
     134-137
Gases
  toxicity of, 134-137
Great Britain
  economic  effects of air pollution
     in,  81
  medical effects of air pollution,
     150-159,  161-169,  171-176

                H
Haze
  particulate  size  distribution  of,
     52-53
High-volume sampler, 22-23
Hydration process
  dust crust, 91-92
Hydrocarbons as carcinogens, 138-
  141
Hygroscopic particles
  effect on pulmonary irritants,
     136
Illumination
  seasonal variation, 37
Industrial odors, 107
International Standard Calibration
  Curve for reflectometers, 21
Irkutsk (U.S.S.R.)
  morbidity studies, 167, 174
Iron
  corrosion of, 65-69
Iron dust
  effect on textiles, 72
Iron oxide
  effects on vegetation, 94
Italy
  morbidity studies, 162, 167, 173,
     174
Japan
  morbidity study, 162, 167, 173,
    174-175
  mortality study, 154, 171
Leaves
  dust effects on, 89-96
Light absorption, 52-53
Light scattering, 9-10, 37-38, 52-
  53, 54-58
Linen
  soiling and deterioration of, 71-
     74
London
  morbidity studies, 154-156,162,
     163, 165-167, 168-169, 172, 173,
     174, 175
  mortality studies, 56-158, 171-
     172
Lung deposition, 118-119
Lung dynamics
  model of, 114-116

                M

Magnesium oxide
  effects on vegetation, 94
Membrane niters, 20
Messthelioma, 129-130
Metals  (see specific metal)
Meuse Valley
  mortality studies, 150
Mie  solutions, 54-55
Morbidity
  correlation with pollution, 148-
  149, 154-156, 161-176
  in children, 165-167
  incapacity for work, 164-165
Mortality
  correlation with  acute  air pollu-
     tion episodes,  148, 150-154
  exposures  to air pollution, 148,
     150-154, 156-161, 169-176
  Long term, 156-161
Motor vehicles
  emissions from, 26
Municipal incineration
  emissions from, 24-25

                N

Nasal fractionation, 118
Nashville, Tennessee
  morbidity studies, 164, 173
  mortality studies, 160, 161, 173
  public opinion survey,  100-101
Nephelometer, 19
New Hampshire (Berlin)
  Morbidity study,  164, 173
New York City
  morbidity studies, 154-156,165,
    170, 171, 173, 176
  mortality studies, 156, 170-171
Nickel
  corrosion of, 67-69
Nitrogen dioxide
  toxicity,  135
Nucleation properties, 8-9
Nuisance surveys, 99-102
                O
Odors
  association with particles, 106-
    107
  emission sources, 107
Open hearth furnaces
  emissions from, 24
Optical density, 20-22
Optical properties, 9-10
Osaka
  mortality study, 154, 171
Paint odors, 107
Painted surfaces
  deterioration of, 71, 72-74
Particle formation mechanisms, 10-
    11
Particle-gas reactions, 10
Particle size
  role in measuring techniques, 149
  role in pulmonary deposition,
    114, 118-119
  role in pulmonary effects, 132-
    133
  distribution, 58, 117
Pennsylvania communities
  morbidity study, 167-168, 175
Philadelphia, Pennsylvania
  economic effects of  air pollution
    in, 83
                                                                                              209

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Photochemical reaction model, 10
Photometry, 20
Photomicrographic atlas, 19
Physiological response, 132-134
Pittsburgh, Pennsylvania
  economic  survey  of  pollution
    damage, 180
Plants
  dust effects on, 89-93
Pneumocoiosis, 122, 131
Pneumonia
  mortality, 157
Polynuclear aromatic hydrocarbons
  carcinogenicity of, 137
Post office employees
  morbidity studies, 163
Precipitation
  influence of particulates  on, 40-
    42
Public opinion surveys, 99-102
Pulmonary flow resistance, 132-
  134
Pulmonary function
  alterations in, 132-134

                R
Race
  relationship to mortality, 156
Rainfall (See Precipitation)
Refinery
  odors from, 107
Reflectance, 21
Reflectometer, 21
Respiratory illness
  relation to smoke level, 148, 162-
    167
Respiratory system
  models of, 114-116
Respiratory tract
  anatomy of, 111-112
Retention
  human  vs.  animal  respiratory
    system, 119
  respiratory system, 112-119
Rotterdam
  morbidity study, 168, 175
Rusting, 65-69, 72-74
Salford, England
  morbidity studies, 164
  mortality studies, 158-159
Sampling methods, 17-23
Scattering coefficient,  55-58
Settling velocities, 16
Sewage
  odors from, 107
Sex
  relationship to mortality, 156
Sheffield, England
  morbidity studies, 167, 168, 170,
    174
Smoke
  corrosive effects, 72-74
  toxicity of, 150-154
Smoke plumes
  optical properties of, 53
Smoke shade
  correlation with mortality, 154
Smoking
  cigarette, 137, 141, 149-150, 158,
    161, 162, 163, 166
Sodium chloride
  corrosive effects, 71
Solar radiation
  effects of particulates on, 35-38
  physical factors effecting, 38-39
  seasonal variations, 39-40
  weekly variations, 39
Soot
  corrosive effects, 65-74
  effects on textiles, 71-74
  effects on vegetation, 89-94
Sorption properties, 8
St. Louis, Missouri
  economic effects of pollution in,
    83
  public opinion survey, 99-100
Steel
  corrosion of, 65-69,  72-74
Stokes law, 5-6
Sulfur dioxide
  corrosive effects, 65
  odor,  107
  toxicity of, 130-131, 132, 136-137
Sulfuric acid
  effects on vegetation, 94
Sulfuric acid manufacturing
  emissions from, 24
Supersaturation
  nuclei, 23
Surface coatings
  deterioration of, 69-71, 72-74
Surface properties, 8-9
Surveys of damage, 79-84
Suspended particulate
  means for urban areas, 11, 13-16
Synergistic effects
  gases and particulate, 135
Synthetic textiles
  soiling and deterioration of, 71-
    74
Syracuse, New York
  economic effects of air pollution
    in, 83
Tape samplers, 20-22
Telephone workmen
  morbidity studies, 162, 163
Tetrahydro naphthalene
  toxicity, 131
Textiles
  soiling and deterioration of, 71-
     74
Toxicity
  adsorbed substances, 130
  intrinsic of particulates, 129-130
  reduction of, 130-131
Transmissivity
  variation with climate, 36
Transmittance, 20-21
Trees
  dust effects on, 90-92
Triphenyl phosphate
  deposition, 117
Turbidimetry, 19
Turbidity,  37


                U

Upper Ohio River Valley
  economic survey  of pollution
     damage, 81,  82
Varnished surfaces
  deterioration of, 69-71, 72-74
Vegetables
  dust effects 'on, 89-96
Visibility, 51-61
  effect of fog upon, 53-54
  effects of natural aerosols on, 53
  effects of particulates on, 36-38,
    53-53
Volatile particles, 106


               W

Washington, D.C.  (Suburban)
  economic effects of air pollution,
    83
Waste decomposition
  odors from, 107

Wool
  soiling and deterioration of, 71-
    74
X-ray diffraction,  19

                Z
Zinc
  corrosion of, 66, 67-68, 72-74
Zinc dust
  effect on textiles, 72
Zinc salts
  corrosive effects, 71
        210

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                          ACKNOWLEDGEMENTS
  The following sources,  in most instances
the copyright holders, have granted permis-
sion to the  National  Air Pollution Control
Administration to  include the following fig-
ures and tables in  the Air Quality Criteria:

Table 1-1.—Los Angeles data courtesy of Los
  Angeles County Air Pollution Control Dis-
  trict

Table p. 26.—Chemical Processing Engineer-
  ing, London

Table p.  27.—American Society of Mechani-
  cal Engineers, New York, N. Y.

Table  2-2.—The  Gray  Printing- Company,
  DuBois, Pennsylvania

Tables 3-1, 8-1.—Air Pollution Control As-
  sociation, Pittsburgh, Pa.

Table 3-2.—Reinhold Book Corporation, New
  York, N. Y.

Table 4-1.—Iron and Steel Institute, London

Tables 4-2, 4-3.—American Society for Test-
  ing & Materials, Philadelphia, Pa.
Table 5-1.—Mellon Institute, Pittsburgh, Pa.
Table  10-2.—American Industrial Hygiene
  Association, Detroit, Mich.
Tables 10-3, 10-4, 11-2, 11-3, 11-4.—Ameri-
  can Medical Association, Chicago, 111.
Table 10-5.—American  Association for the
  Advancement of Science, Washington, D.C.

Table  10-6.—National Tuberculosis & Res-
  piratory Disease Association,  New  York,
  N. Y.
Table  11-1.—Pergamon   Press,   Inc.,  New
  York, N. Y.
Figure  1-1.—Academic  Press,  Inc.,  New
  York, N. Y.

Figures 1-3, 2-2, 3-1, 3-4, 3-5, 3-6, 9-4, 9-5,
  9-6,  9-7.—Pergamon  Press  Inc.,  New
  York, N. Y.

Figure  1-4.—American Industrial Hygiene
  Association, Detroit, Mich.

Figures 2-1, 3-7, 7-2.—Air Pollution Control
  Association, Pittsburgh, Pa.

Figures 2-3, 2-4,11-2.—Controller, Her Maj-
  esty's Stationary Office, London, England
Figures 2-5,  3-1,  3-3.—American Meteoro-
  logical Society, Boston, Mass.

Figure  3-8.—American  Chemical  Society,
  Washington, D. C.

Figure 4-1.—Iron and Steel Institute, Lon-
  don, England

Fiyuio 4-2.—American Society for Testing
  & Materials, Philadelphia, Pa.

Figure  4-3.—District of Columbia  Health
  Department, Washington, D. C.

Figure 5-1.—Environmental Health & Safety
  Research Associates, New Rochelle, New
  York
Figures 6-1, 6-2, 6-3.—Ellis F. Darley, Uni-
  versity of California, Riverside, Calif.
Figure 11-1.—Royal Society of Health, Lon-
  don, England
Figure 11-3.—Royal Dublin Society, Dublin,
  Ireland

Figure  11-7.—American  Medical Associa-
  tion, Chicago, 111.

Figure 11-8.—British Medical Journal, Lon-
  don, England
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