Carcinogen Assessment Groups List Of Carcinogens


450R80104
                         THE CARCINOGEN ASSESSMENT GROUP'S

                                LIST OF CARCINOGENS

                                   July 14, 1980
         Footnote added to page 1 of the list for clarification, May 24,  1982
                                      n Ajjonoy
                                 <,,,, ..... ,L
                                 i > COt

-------
U,S. Environmental Protection  Agency

-------
                  CHEMICALS HAVING EVIDENCE OF CARCINOGEN1CITY

    In response to requests from several  EPA offices, the Carcinogen Assessment
Group (CAG), Office of Health and Environmental  Assessment in EPA's Research and
Development Office has prepared a list of chemical  substances for which
substantial or strong evidence exists showing that exposure to these chemicals,
under certain conditions, causes cancer in humans,  or can cause cancer in animal
species which in turn, makes them potentially carcinogenic in humans.
    The list was initially prepared in response to the needs of the Office of
                    ^
Pesticides and Toxic Substances (OPTS) to develop labeling regulations under
section 6 of TSCA and the Office of Solid Waste (OSW) to develop hazardous waste
regulations under section 3001 of RCRA.  It is anticipated that it will serve
other purposes within the Agency according to the needs of the program offices.
    The sources of information used in selecting agents as candidates for the
list are of two types:  chemicals which the Carcinogen Assessment Group
previously has evaluated and has determined pose a potential human cancer risk;
and chemicals, the carcinogenicity of which the CAG reviewed because one or more
of three organizations — the International Agency for Research on Cancer
(IARC), the National Cancer Institute Bioassay Program which has been
reorganized into the National Toxicology Program (NTP), and the Food and Drug
Administration (FDA) of the U.S. Department of Health and Human Services — had
concluded that these chemicals are potentially human carcinogens.  (Chemicals
regulated as carcinogens by the Occupational Safety and Health Administration
(OSHA) and the Consumer Product Safety Commission (CPSC) are also on this list
but are not noted as such since they have been evaluated as being carcinogens by
one of the other organizations previously mentioned).  CAG evaluated the studies
upon which IARC, NTP, or FDA relied and agreed with all the NTP and FDA

-------
evaluations that the chemicals presented a potential  human cancer risk.  The CAG
agreed with most of lARC's evaluations.  There are inconsistencies between the
CAG and IARC evaluations for a few chemicals because  the CAG considered
information not available to or not otherwise used by IARC, and because there
are differences in the criteria used in making the qualitative evaluations.
    The list is not a comprehensive listing of _a_T[ chemicals having substantial
                                                              >
or strong evidence of carcinogenicity.  As the CAG continues to analyze
chemicals for carcinogenicity, chemicals which do not now appear on the list
will  be added.  A continuing review of evaluations by organizations such as
IARC, NTP, FDA, OSHA, and CPSC may result in periodic revisions to the present
list.
    The CAG evaluates substances for possible carcinogenicity according to the
procedures outlined in the Agency's Interim Guidelines for Carcinogen Risk
Assessment found in Interim Procedures and Guidelines for Health Risk and
Economic Impact Assessments of Suspected Carcinogens  (41 Fed. Reg. 21402, May
25, 1976).  These guidelines are consistent with the  Interagency Regulatory
Liaison Group's Scientific Bases for Identification of Potential Carcinogens and
Estimation of Risks (Journal of the National Cancer Institute J53_ (l):243-268
1979, 44 Fed. Reg. 39858, July 6, 1979), and the Regulatory Council Statement on
Regulation of Chemical Carcinogens (44 Fed. Reg. 760037, October 17, 1979).
    Evidence concerning the carcinogenicity of chemical  substances is of three
types:  (1) epidemiologic evidence derived from studies of exposed human
populations; (2) experimental  evidence derived from long-term bioassays on
animals; and (3) supportive or suggestive evidence derived from studies of
chemical-structure or from short-term mutagenicity, cell transformation or other
tests that are believed to correlate with carcinogenic activity.
     The CAG evaluates all available evidence on the  carcinogenicity of a

-------
chemical  before reaching a conclusion based on the "weight of the evidence,"
about the chemical's human carcinogenic potential.  Conclusions about the
overall weight of evidence involve a consideration of the quality and adequacy
of the data and the kinds of responses induced by the suspect carcinogen.  The
best evidence that an agent is a human carcinogen comes from epidemiologic
studies in conjunction with confirmatory animal  tests.   Substantial  evidence is
                                                              i
provided by animal tests that demonstrate the induction of malignant tumors in
one or more species or of benign tumors that are generally recognized as early
stages of malignancies.  Suggestive evidence includes indirect tests of
tumorigenic activity, such as mutagenicity, in vitro cell  transformation, and
initation-promotion skin tests in mice.  Ancillary data that bear on judgments
about carcinogenic potential, e.g., evidence from systematic studies that relate
chemical  structure to carcinogenicity, are also considered.
    Substances were placed on the CAG list only if they had been demonstrated to
induce malignant tumors in one or more animal species or to induce benign tumors
that are generally recognized as early stages of malignancies, and/or if
positive epidemiologic studies indicated they were carcinogenic.  Although the
CAG has determined that there is substantial evidence of carcinogenicity for
each chemical substance on the list, the data varies to some extent  with respect
to the scope and quality of the studies.
    Not uncommonly, CAG reports are updated because new evidence becomes
available.  Because of this, it is important that the most recent CAG evaluation
be consulted.

-------
                                      4


     Some of the reports prepared by CAG are subject to confidentiality

claims.  Because of these claims (primarily under the Federal Insecticide,

Fungicide, and Rodenticide Act) some reports may not be released.  Therefore,
                                             *
all requests for CAG reports and related documentation must be submitted

through EPA's Freedom of Information Office '(A-101), Washington, D. C. 20460,

and should be marked CAG/LOC.

-------
         CHEMICALS HAVING SUBSTANTIAL* EVIDENCE OF CARCINOGENICITYb


2-Acetylaminoflourene (See references)

Acrylonitrile (CAG, IARC)

Aflatoxins (IARO*

Aldrin (CAG, NCI)

4-Anrinobiphenyl  (IARC)

Amltrole (IARC)

Aramlte (IARC)

Arsenic and Arsenic Compounds (CAG, IARC)

Asbestos (CAG, IARC)

Auramine and the manufacture of Auramine (IARC)

Azaserine (IARC)**

Benz(c)acridine  (IARC)@

Benz(a)anthracene (IARC)

Benzene (CAG, IARC)
    aAs applied here the term substantial  has been used to cover carcinogenic
evidence ranging from single, clear-cut responses in animal  studies to stronger
evidence from responses in multiple species and results from human  studies.
This term covers the IARC categories of limited and sufficient evidence from
both human and animal studies.  The IARC classification system was  not used  in
compiling this list, although the chemicals on this list could be further
stratified using these criteria.  (Added for clarification,  May 24, 1982.)

    ^This is not a comprehensive list of all chemicals having substantial
evidence of carcinogenicity.  Other chemicals will be added.  No attempt has
been made to select chemicals based upon appropriateness for regulation by EPA.
The list is intended to be a basis for selection by the various program offices
according to their specific needs.


    *Fungal toxin, not an industrially manufactured product.

    **Used as a drug.

    ©Evaluated by IARC as not having sufficient evidence of carcinogenicity.

-------
Benzidine (GAG, IARC)

Benzo(a)pyrene (IARC)

Benzo(b)fluoranthene (IARC)

Benzo(j)fluoranthene (IARC)@

Beryllium and Beryllium Compounds {CAG, IARC)

N,N-Bis(2-Ch1oroethyl)-2-Napthylamine (Chlornaphazine)  (IARC)**

Cadmium and Cadmium Compounds (CAG, IARC)

Carbon Tetrachloride (CAG, IARC)

Chlorambucil  (IARC)**

Chloroalkyl Ethers
  Bis(2-chloroethyl)ether (BCEE)  (CAG)(IARC)@
  Bis(chloromethyl)ether (BCME)  (CAG, IARC)
  Chloromethyl methyl ether (CMME), technical  grade (IARC)

Chlordane (CAG, NCI)
                                                ^..
Chlorinated Ethanes
  1,2-Dichloroethane [Ethylene Chloride, Ethylene  Dichloride (EDC)]
     (CAG, IARC, NCI)
  Hexachloroethane (CAG)
  1,1,2,2-Tetrachloroethane (CAG)
  1,1,2-Trichloroethane (CAG, NCI,IARC)@

Chiorobenzilate (CAG)

Chloroform (CAG, IARC)

Chromium Compounds, Hexavalent (CAG, IARC)

Chrysene (IARC)@

Citrus Red No. 2 (IARC)

Coal Tar and Soot (CAG, included in lARC's  soots,  tars, and oils designation)

Coke Oven Emissions [Polycyclic Organic Matter (POM)] (CAG)

Creosote (CAG)

Cycasin (IARC)

Cyclophosphamide (IARC)**
    **Used as a drug.

    ^Evaluated by IARC as not having sufficient evidence of carcinogenicity.

                                       2

-------
Daunomycin (IARC)**
DDT (Dichlorodiphenyltrichloroethane) (CAG)
Dial late (CAG)(IARC)@
Dibenz(a,h)acridine (IARC)
Dibenz(a,j)acridine (IARC)
Dibenz(a,h)anthracene (IARC)
7H-Dibenzo(c,g)carbazole (IARC)
Dibenzo(a,e)pyrene (IARC)
                                                              >
Dibenzo(a,h)pyrene (IARC)
Dibenzo(a,i)pyrene (J-ARC)
l,2-Dibromo-3-chloropropane (DBCP) (CAG, IARC, NCI)
1,2-Dibromoethane [Ethylene Bromide, Ethylene Dibromide (EDB)] (NCI,
  CAG, IARC)
3,3'-Dichlorobenzidine (DCB) (CAG, IARC)
Dieldrin (CAG)
Diepoxybutane (IARC)
1,2-Diethylhydrazine (IARC)
Diethylstilbestrol (DES) (IARC)**
Dihydrosafrole (IARC)
3,3'-Dimethoxybenzidine (o-Dianisidine)  (IARC)
p-Dimethylaminoazobenzene (IARC)
7,12-Dimethylbenz(a)anthracene (See references)
3,3'-Dimethylbenzidine (o-Tolidine) (IARC)
Dimethylcarbamoyl Chloride (IARC)
1,1-Dimethylhydrazine (IARC)
1,2-Dimethylhydrazine (IARC)
Dimethyl Sulfate (IARC)
    **Used as a drug.
    ^Evaluated by IARC as not having sufficient evidence of carcinogenicity.
                                       3

-------
2,4-Dinitrotoluene (CAG, NCI)
1,4-Oioxane (NCI)
1,2-Diphenylhydrazine (CAG)
Epichlorohydrin (CAG)
Ethylene Bis Dithiocarbamate (EBDC) (CAG)
Ethyl eneimine (Aziridine) (IARC)@
Ethylene Oxide (CAG, IARC)
Ethylenethiourea (CAG, IARC)
Ethyl  Methanesulfonate (IARC)
Formaldehyde (CAG)
Glycidaldehyde (IARC)
Heptachlor (CAG,  NCI)
Hexachlorobenzene (CAG, IARC)
Hexachlorobutadiene (CAG)
Hexachlorocyclohexane (HCH)
  a HCH (CAG)
  3 HCH (CAG)
  Y HCH (Lindane) (CAG)
  Technical  HCH (CAG)
Hydrazine (IARC)
Indeno(l,2,3-cd)pyrene (IARC)
Iron Dextran (IARC)**
-------
Methapyrilene (FDA)**

3-Methylcholanthrene (See references)

4,4'-Methylenebis(2-Chloroaniline) (MOCA) (IARC)

Methyl Iodide (CAG, IARC)

Methyl Methanesulfonate (IARC)

N-Methyl-N'-nitro-N-nitrosoguanidine (IARC)

Methylthiouracil (IARC)**

Mitomycin C (IARC)**

Mustard Gas (IARC)

1-Naphthylamine, technical grade (CAG)

2-Naphthylamine (IARC)

Nickel and Nickel  Compounds (CAG, IARC)

Nitrogen Mustard and its hydrochloride (IARC)

Nitrogen Mustard N-oxide and its hydrochloride (IARC)

5-Nitro-o-toluidine (NCI)

4-Nitroquinoline-l-oxide (See references)

Nitrosamines
  N-Nitrosodiethanolamine (IARC)
  N-Nitrosodiethyl amine (DENA) (CAG, IARC)
  N-Nitrosodimethylamine (DMNA) (CAG, IARC)
  N-Nitrosodi-n-butylamine (IARC)
  N-Nitrosodi-n-propylamine (IARC)
  N-Ni trosomethylethyl ami ne (IARC)
  N-Nitrosomethylvinylami ne (IARC)
  N-Nitroso-N-Ethylurea (NEU) (CAG, IARC)
  N-Nitroso-N-Methylurea (NMU) (CAG, IARC)
  N-Nitroso-N-methylurethane (IARC)
  N-Nitrosomorpholine (IARC)
  N-Nitrosonornicotine (IARC)
  N-Nitrosopiperidine (IARC)
  N-Nitrosopyrrolidine (IARC)
  N-Nitrososarcosine (IARC)
    **Used as a drug.

    @Evaluated by IARC as not having sufficient evidence of carcinogenicity.
-------
Pentachloronitrobenzene (PCNB) (CAG)
Phenacetin (IARC)**
Polychlorinated Biphenyls (PCBs)  (CAG, IARC)
Pronamide (CAG)
1,3-Propane Sultone (IARC)
S-Prop1olactone (IARC)
Propylthiouracil  (IARC)**
Reserpine (NCI)**
Saccharin (FDA)***
Safrole (CAG, IARC )***
Selenium Sulfide (NCI)
Streptozotocin (IARC)**
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDO) (CAG)
                                                n^
Tetrachloroethylene (Perch!oroethylene) (CAG, NCI)
Thioacetamide (IARC)
Thiourea (IARC)
o-Toluidine Hydrochloride (NCI)
Toxaphene (CAG,IARC,  NCI)
Trichloroethylene (CAG, NCI)
2,4,6-Trichlorophenol  (NCI)
Tr1s(l-az1r1d1nyl)phosphtne sulfide (Thio-TEPA)  (IARC, NCI)**
Tris(2,3-dibromopropyl)phosphate  (IARC, NCI)
Trypan Blue, commercial  grade (IARC)
(Jracil Mustard (IARC)**
Urethane (IARC) (Ethyl carbamate; ethyl ester of carbamic acid)
Vinyl  Chloride (CAG,  IARC)
Vinylidene Chloride (CAG)
    **Used as a drug.
    ***Used as a food.
-------
              CARCINOGENS FOR WHICH CAG REPORTS HAVE BEEN PREPARED
Acrylonitrile
Aldrin/Dieldrin
Arsenic
Asbestos
Benzene
Benzidine
Beryllium
Cadmium
Carbon Tetrachloride
Chi oralkyl Ethers
  Bis (2-Chloroethyl) Ether (BCEE)
  Bis (Chloromethyl) Ether (BCME)
Chlordane
Chlorinated Ethanes
  1,2-Dichloroethane
  Hexachloroethane
  1,1,2,2-Tetrachloroethane
  1,1,2-Trichloroethane
Chiorobenzilate
Chloroform
Chromi um
Coal Tar
Coke Oven Emissions
Creosote
DDT (Dichlorophenyltrichloroethane)
Dial! ate
-------
l,2-Dibromo-3-ch1oropropane (DBCP)
1,2-Dibromoethane [Ethylene Dibromide (EDB)]
3,3-Dichlorobenzidine (DCB)
Dieldrin (See Aldrin/Dieldrin)
2,4-Di ni trotoluene
1,2-Di pheny1hydrazi ne
Epichlorohydrin
Ethylene Bis  Dithiocarbomate (EBDC)
Ethylene Oxide
                    *
Formaldehyde
Heptachlor
Hexachlorobenzene
Hexachlorobutadiene
Hexachlorocyclohexane (HCH, BHC)
Kepone
Methyl Iodide
1-Naphthylamine, technical grade
Nickel
Nitrosamines
  N-Nitrosodimethylamine (DMNA)
  N-Nitrosodiethylamine (DENA)
  N-Nitroso-N-Methylurea (NMU)
  N-Nitroso-N-Ethylurea (NEU)
Pentachloronitrobenzene (PCNB)
Polychlorinated Biphenyls (PCBs)
Pronamide
-------
Safrole
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
Tetrachloroethylene (Perch!oroethylene)
Toxaphene
Trichloroethylene
Vinyl Chloride
Vinylidene Chloride
-------
                         CARCINOGENS EVALUATED  BY  IARC            !
                 CHEMICAL                         IARC MONOGRAPH/PAGE 1

  Acrylontrile                                        19,  73
  Aflatoxins                                          1,  145;  ]_, 319,  B, 349
  4-Aminobiphenyl                                     ]_,  74;  J£, 343
  Amitrole                                            ]_,  31
  Aramite                                             5_,  39
                                                               >
  Arsenic & Inorganic Arsenic Compounds               2_,  48
  Asbestos                                            2,  17;  _7,  319: ]±;  ]5_,
                                                      341; ]]_, 351
  Auramine and the manufacture of Auramine            1,  69;  1_,  319
  Azaserine                                           10,  73
  Benz(c)acridine@                                    3.,  241
  Benz(a)anthracene                                   3_,  45
  Benzene                                             ]_,  203;  _!_!_,  295
  Benzidine                                           1.,  80
  Benzo(a)pyrene                                      3_,  91
  Benzo(b)fluoranthene                                3_,  69
  Benzo(j)fluoranthene@                               3_,  82
  Beryllium and Beryllium Compounds                   J_,  17
  N,N-Bis(2-Chloroethyl)-2-Naphthylamine              4_,  119
  Cadmium and Cadmium Compounds                       ,2_,  74; 11,  39
  Carbon Tetrachloride                                1,  53; 20,  371
  Chlorambucil                                        9_,  125
  Chloroalkyl Ethers
      Bis (2-Chloroethyl)ether (BCEE)@                £,  117
      Bis (Chloromethyl) Ether                        4,  231;   U_,  243,
      Chloromethyl methyl ether, technical  grade      T,  239

@Evaluated by IARC as not having sufficient  evidence of carcinogenicity.
-------
                 CHEMICAL
IARC MONOGRAPH/PAGE 2
  Chlorinated Ethanes
      1,2-Dichloroethane
      1,1,2-Trichloroethane@
  Chloroform
  Chromium Compounds, Hexavalent
  Chrysene@
  Citrus Red No. 2
  Cycasin
  Cyclophosphamide
                    ^
  Daunomycin
  Diallate@
  Dibenz(a,h)acridine
  Dibenz(a,j) acridine
  Dibenz(a, h)anthracene
  7H-Dibenzo(c,g) carbazole
  Dibenzo(a,e)pyrene
  Dibenzo(a,h)pyrene
  Dibenzo(a,i)pyrene
  l,2-Dibromo-3-chloropropane
  1,2-Dibromoethane
  3,3'-Dichlorobenzidi ne
  Diepoxybutane
  1,2-Diethylhydrazine
     20_, 429
     _20, 515
     _20_, 401
     2, TOO
     _3, 159
     8_, 101; J_9> 495
     _]_, 157; 7_, 319; ]_£» 121
     9_, 135
     J£, 145
     12, 69
     3, 247
     _3, 254
     _3, 178
     _3, 260
     I, 201
     I, 207
     3_, 215
     15, 139
     |5_, 195
     £, 49
     Jl, 115
     £, 153
^Evaluated by IARC as not having sufficient evidence of carcinogenicity.
-------
                 CHEMICAL                         IARC  MONOGRAPH/PAGE 3

  Diethyl stilbestrol                                   6.,  55
  Dihydrosafrole                                       1,  170;  ]J),  233
  3,3'-Dimethoxybenzidine                              _4,  41
  p-Dimethylaminoazobenzene                            8_,  125
  3,3'-Dimethylbenzidine                               ]_,  87
  Dimethylcarbamoyl Chloride                           12,  77
  1,1 -Dimethyl hydrazine                                _4,  137
  1,2-DimethyThydrazine                                £,  145;  _7, 320
  Dimethyl  Sulfate                                     4_,  271
  Ethyleneimine?                                       9_,  37
  Ethylenethiourea                                     ]_,  45
  Ethyl Methanesulfonate                          ,.     _7»  245
  Glycidaldehyde                                       H,  175
  Hexachlorobenzene                                    20,  155
  Hydrazine                                            _4,  127
  Indeno(l,2,3-cd)pyrene                               _3,  229
  Iron Dextran@                                        _2,  161
  Isosafrole                                           1,  169; JJD, 232
  Lasiocarpine                                         10,  281
  Melphalan                                            9_,  167
  4,4'- Methylenebis(2-Ch1oroaniline)                  £,  65
  Methyl Iodide                                        15,  245
  Methyl Methanesulfonate                              7_,  253
  N-Methyl-N'-nitro-N-nitrosoguanidine                 4_,  183

^Evaluated by IARC as not having sufficient  evidence of carcinogenicity.
-------
                 CHEMICAL                        IARC MONOGRAPH/PAGE  4


Methylthiouracil                                    ]_, 53

Mitomycin C                                         JO., 171

Mustard Gas                                         9_, 181 ;  J_3, 243

1-Naphthylamine, technical grade                    £, 87; _8, 349

2-Naphthylamine                                     _4, 97

Nickel and Nickel Compounds                         2_, 126;  7_, 319;  Vl_, 75

Nitrogen Mustard and its hydrochloride              _9> ^3    •

Nitrogen Mustard M-oxide and its hydrochloride      _9_, 209
                    ^
NITROSAMINES

    N-Nitrosodiethanolamine                         17, 77
    N-Nitrsodiethylamine                            J7 107;  JJ_, 295: YJ_, 83
    N-Nitrosodimethylamine                          J_, 95, 17, 125
    N-Nitrosodi-n-butylamine                        £, 197, 17, 51
    N-Nitrosodi-n-propylamine                       17, 177
    N-Nitrosomethylethyl amine                    H   T7, 221
    N-Nitrosomethyl vinyl ami ne .                   "*  T7, 257
    N-Nitroso-N-Ethylurea                           J7 135, J7, 191
    N-Nitroso-N-Methylurea                          1, 125, j_7_, 227
    N-Nitroso-N-Methylurethane                      T, 211
    N-Nitrosomorpholine                             17, 263
    N-Nitrosonornicotine                            17, 281
    N-Nitrosopiperidine                             T7, 287
    N-Nitrosopyrrolidine                            T7, 313
    N-Nitrososarcosine                              T7, 327

Phenacetin                                          13. 141

Polychlorinated Biphenyls                           7_, 261; J8_, 43

1,3-Propane Sultone                                 _4, 253;  J_3, 243

1-Propiolactone                                     £, 259;  J_5, 341

Propylthiouracil                                    7_, 67

Safrole                                             1, 169, J£, 231

Soots, tars, and oils                               _3, 22
-------
                  3HEMICAL                         IARC MONOGRAPH/PAGE 5
Streptozotocin                                       £,  221, V7, 337



Thioacetamide                                        ]_,  11


Thiourea                                             ]_,  95



Toxaphene                                   '         20_, 327


Tris(aziridinyl)phosphine sulfide  (Thio-TEPA)        _9,  85



Tris(2,3-dibromopropyl)phosphate                     20, 575
                                                               >

Trypan Blue (commercial grade)                       _8,  267



Uracil Mustard      "                                9_»  235


Urethane                                             ]_,  111


Vinyl Chloride                                       7_,  291; J9_, 377
-------
             COMPOUNDS EVALUATED BY  IARC  BUT  NOT  AS  HAVING  SUFFICIENT
                          EVIDENCE OF CARCINOGENICITY
Benz(c)acridine                                             _3_,  241
Benzo(j)f1uoranthene                                        3_,  82
Bis(2-chloroethyl) Ether     ,      .                         1,117
Chrysene                            .                        J.,  159
Dial!ate                                                    12, 69
Ethyleneimine (Aziridine)                                   9_,  37
                                                            ~~ >
Iron Detran                                                 _2,  161
1,1,2-Trichloroethane*                   .                   22, 533
-------
International  Agency for Research on Cancer.   1972.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 1.  Some
    inorganic  substances, chlorinated hydrocarbons,  aromatic amines, N-Nitroso
    compounds, and natural  products.  Lyon, France.   184 pp.

International  Agency for Research on Cancer.   1973.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 2.  Some
    inorganic  and organometallic compounds.  Lyon,  France.  181  pp.

International  Agency for Research on Cancer.   1973.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 3.
    Certain polycyclic aromatic hydrocarbons  and heterocyclic compounds.  Lyon,
    France.  271  pp.

International  Agency for Research on Cancer.   1974.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 4.  Some
    aromatic amines, hydrazine and related substances,  N-Nitroso compounds and
    miscellaneous al-kylating agents.  Lyon, France.   286 pp.

International  Agency for Research on Cancer.   1974.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 5.  Some
    organochlorine pesticides.   Lyon, France.  241  pp.

International  Agency for Research on Cancer.   1974.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 6.  Sex
    hormones.   Lyon, France.  243 pp.

International  Agency for Research on Cancer.   1974.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 7.  Some
    anti-thyroid and related substances, nitrofurans and industrial  chemicals.
    Lyon, France.  326 pp.

International  Agency for Research on Cancer.   1975.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 8.  Some
    aromatic azo compounds.  Lyon, France.  357 pp.

International  Agency for Research on Cancer.   1975.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 9.  Some
    aziridines, N-, S- and 0-Mustards and selenium.   Lyon, France.   268 pp.

International  Agency for Research on Cancer.   1976.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 10.   Some
    naturally occurring substances.  Lyon, France.   353 pp.

International  Agency for Research on Cancer.   1976.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 11.
    Cadmium, nickel, some epoxides, miscellaneous industrial chemicals and
    general considerations on volatile anaesthetics.  Lyon, France.   306 pp.

International  Agency for Research on Cancer.   1976.   IARC monographs on the
    evaluation of the carcinogenic risk of chemicals to humans.   Vol. 12.   Some
    carbamates, thiocarbamates and carbazides.  Lyon, France.  282  pp.
-------
International  Agency for Research on Cancer.   1977.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Vol.  13.   Some
    miscellaneous pharmaceutical  substances.   Lyon,  France.   255  pp.

International  Agency for Research on Cancer.   1977.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Vol.  14.
    Asbestos.   Lyon, France.   106 pp.

International  Agency for Research on Cancer.   1977.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Vol.  15.   Some
    fumicants, the herbicides 2,4-D and  2,4,5-T,  chlorinated dibenzodioxins and
    miscellaneous industrial  chemicals.   Lyon, France.   354  pp.

International  Agency for Research on Cancer.   1978.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Vol.  16.   Some
    aromatic amines and related nitro  compounds —  hair dyes,  colouring agents
    and miscellaneous,, industrial  chemicals.   Lyon,  France.   400  pp.

International  Agency for Research on Cancer.   1978.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Vol.  17.   Some
    N-Nitroso  compounds.  Lyon, France.   364  pp.

International  Agency for Research on Cancer.   1978.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Vol.  18.
    Polychlorinated biphenyls and polybrominated  biphenyls.   Lyon,  France.
    140 pp.

International  Agency for Research on Cancer.   1979.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Vol.  19.   Some
    monomers,  plastics and synthetic elastomers,  and  acrolein.   Lyon,  France.
    513 pp.

International  Agency for Research on Cancer.   1979.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Vol.  20.   Some
    halogenated hydrocarbons.  Lyon, France.   609 pp.

International  Agency for Research on Cancer.   1979.   IARC monographs  on the
    evaluation of the carcinogenic risk  of chemicals  to humans.   Supplement 1.
    Chemicals  and industrial  processes associated with  cancer in  humans.  Lyon,
    France.   71 pp.
-------
 CHEMICALS EVALUATED AS BEING CARCINOGENIC BY MCI
NATIONAL CANCER INSTITUTE
 CARCINOGENESIS TECHNICAL
   REPORT SERIES NUMBER
Aldrin
Chlordane
1,2-Dibromo-3-chloropropane (DBCP)
1,2-Dibromoethane
1,2-Dichloroethane  [Ethylene Chloride,
   Ethylene Oichloride (EDC)]
2,4-Dinltrotoluene
1,4-Dioxane         ,
Heptachlor
Kepone
Lasiocarpine
5-Nitro-o-toluidine
Reserpine
Selenium Sulfide
Tetrachloroethylene (Perchloroethylene)
o-Toluidine Hydrochloride
Toxaphene
Trichloroethylene
2,4,6-Trichlorophenol
Tris(l-aziridinyl)phosphate sulfide (Thio-TEPA)
Tris (2,3-dibromopropyl) phosphate
            21
             8
            28
            86
            55

            54
            80
             9
    NTIS # PB-264041/AS
            39
           107
           193
           194
            13
           153
            37
             2
           155
            58
            76
Copies of the reports may be puchased from the National Technical  Information
Service, US Department of Labor, 5285 Port Royal  Road, Springfield, VA  22161
-------