740R88101 EPA Chemical Profiles for Extremely Hazardous Substances U.S. Environmental Protection Agency June, 1988 ------- ------- EPA CHEMICAL PROFILES INTRODUCTORY INFORMATION AND FULL PROFILES TABLE OF CONTENTS BACKGROUND 1 DISCUSSION OF SECTIONS OF PROFILES 2 PERSONAL PROTECTIVE EQUIPMENT 5 ABBREVIATIONS 11 GLOSSARY 13 REFERENCES 23 PROFILES BY CAS NUMBER* June 1988 * Chemical Abstracts Service Registry Number. ------- EPA CHEMICAL PROFILES: INTRODUCTORY INFORMATION BACKGROUND The U.S. Environmental Protection Agency has developed & set of chemical profile reference documents for use in dealing with Section 302 of Title III of the Superfund Amendments and Reauthorization Act (SARA). These EPA profiles contain a summary of publicly available documented information for chemicals on the EPA list of extremely hazardous substances listed in the Federal Register, Vol. 52, No. 77, April 22, 1987. The profiles were originally developed in 1985 for the 402 chemicals then called "acutely toxic chemicals" under the Chemical Emergency Preparedness Program. When the list went into law as the list of extremely hazardous substances, four additional chemicals were included. Forty of the 406 chemicals were subsequently deleted from the list. Profiles are provided for the 366 chemicals listed in February, 1988, as extremely hazardous substances. Other chemicals may be added or deleted in the future. The . profile format was revised and the data were reviewed, augmented, and revised as appropriate in 1987. The profiles have been reviewed for accuracy and completeness. However, an exhaustive literature search was not performed for each chemical, and a review of original citations has not been made. • A profile is provided for each chemical on the list of extremely hazardous substances. Profiles are presented in ascending order of Chemical Abstract Service (CAS) registry numbers. One chemical (generic name: organorhodium complex) is identified by a premanufacture review notice (PMN) number and appears first. The CAS number was used to search the automated Toxicology Data Base (TDB) or Hazardous Substance Data Bank (HSDB) from the National Library of Medicine (NLM). If available, TDB/HSDB files were retrieved. Approximately 65 percent of the chemicals were listed in the TDB/HSDB files. For these chemicals, the TDB/HSDB files provided the main source of information for the profiles. All data obtained from the TDB/HSDB were indicated by an asterisk (*) followed by a reference to the TDB/HSDB citation, (e.g., (*Merck 1976)). For those chemicals without a TDB/HSDB file, a limited number of standard reference materials was searched. Such references are cited by author, year, and page number. A master list of references, including the secondary references cited in TDB/HSDB, has been prepared and may be found in the Reference Section of this document. The abbreviations used in the profiles have been defined in a master list and may be found in the Abbreviation Section. Medical terms not commonly used have been included in a Glossary Section. Dorland's Medical Dictionary (1974) was used to provide most of the definitions in the Glossary. If information was not available for a specific compound but the chemical could be categorized, then general information about the chemical category was included. Such information is indicated, for example, by the notation "Non-Specific -- Organophosphorus Pesticide" or "Non-Specific -- Poisonous Solid, n.o.s.". ------- -2- DISCUSSION OF SECTIONS OF PROFILES Each profile includes chemical identity information and eight sections containing information on regulations, properties, hazards, uses, and precautions. Comments on the elements of the profiles are presented below. Chemical Identity. The name given on the profile is the name used on the list of extremely hazardous substances (Section 302 of SARA Title III) and is one of the most common names. CAS Registry Number. The number is identical to the number listed in the National Institute of Occupational Safety and Health (NIOSH) Registry of Toxic Effects of Chemical Substances (RTECS). Synonyms. Synonyms from TDB/HSDB files are listed without citation. Synonyms from NIOSH/RTECS (1983) or the Structure and Nomenclature Search System (SANSS) (1983) , or other sources are referenced. The 9th Collective Index (CI) name from the SANSS 1983 database was added to each profile when the 9th CI name was different from the 8th CI name. Chemical Formula and Molecular Weight. Data from TDB/HSDB or NIOSH/RTECS (1983) are not cited. Formulas or molecular weights found in other sources are cited. Section I -- Regulatory Information. The toxicity value that placed the chemicals on the list has been included in this section. These toxicity data were obtained from a screen of the NIOSH/RTECS on-line computer file and are also cited with an asterisk (*) (e.g., *NIOSH/RTECS 1985). Toxicity data were not included for chemicals listed on the basis of high production volume and known toxicity ("Other" chemicals). Also included are Threshold Planning Quantities (TPQs) and Reportable Quantities (RQs), as listed in the Final Rule (Federal Register, Volume 52, Number 77, April 22, 1987). An indication of whether the chemical is listed under Section 313 of Title III of SARA is included; if the chemical falls into a chemical category listed in Section 313, the category is given. Section II -- Physical/Chemical Characteristics. Physical state (solid, liquid, or gas) at ambient conditions is listed, as given in the Interim Final Rule (Federal Register, Vol. 51, No. 221, November 17, 1986); no reference is cited on the profiles. Other properties are included with references. Section III -- Health Hazard Data. Generally, only human data are reported in the Health Hazard Data section. The following exposure limits are included, if available: • Occupational Safety and Health Administration (OSHA) Permissible Exposure Limits (PELs); • American Council of Governmental Industrial Hygienists (ACGIH) Threshold Limit J/alues (TLVs); and ------- -3- • Immediately Dangerous to Life and Health (IDLH) levels developed by N10SH. The following limits may be listed under Other Limits Recommended, if available: • NIOSH recommendations; • EEGLs (emergency exposure guidance levels); • SPEGLs (short-term public emergency guidance levels); • Human carcinogens or suspect carcinogens listed by the ACGIH; • OSHA carcinogens; and • NIOSH potential occupational carcinogens. EEGLs and SPEGLs, developed by the National Research Council of the National Academy of Sciences, are discussed in more detail in Appendix D of the Technical Guidance for Hazards Analysis (EPA 1987). An EEGL is defined as an acceptable concentration for unpredicted, single, short-term emergency exposure of a defined occupational group (EEGLs have been developed for military personnel). A SPEGL is defined as an acceptable concentration for unpredicted, single, short-term, exposure of the general public in emergencies. Information on the route of exposure and health hazards often was not available or only partially available for specific chemicals. Health hazard data often were not found specific to dose, route of entry or exposure type (acute, delayed, or chronic). Generic information on the chemical category was provided, wherever possible, in the absence of information on the specific chemical. Section IV -- Fire and Explosion Hazard Data. In the absence of chemical-specific information, generic information is provided whenever the chemical could be categorized. National Fire Protection Association (NFPA) flammability ratings from the NFPA Fire Protection Guide on Hazardous Materials are included if available. Section V -- Reactivity Data. In the absence of chemical-specific information, generic information is provided whenever the chemical could be categorized. Section VI -- Use Information. This section includes uses of the chemical as reported in HSDB or other sources. Section VII -- Precautions for Safe Handling and Use. Chemical- specific information often was not available; therefore, generic information for the chemical category often is presented. Section VIII -- Protective Equipment for Emergency Situations. This section contains recommendations for the type of personal protective equipment to be used. See page 5 for a detailed discussion of personal protective equipment. Section IX -- Emergency Treatment Information. This section contains information on signs and symptoms of poisoning and emergency treatment information for first responders. Emergency planners may be especially ------- -4- interested in references to medical equipment and supplies that could be useful in case of the accidental release of the extremely hazardous substance. Approximately 120 of the revised chemical profiles contain complete revisions of the emergency treatment information section and have been retitled the Emergency First Aid Treatment Guide (EFATG). This new section has been reformatted and contains more detailed guidance for emergency treatment based on information obtained from the Rocky Mountain Poison Center's proprietary data base, Poisindex. The order of completion of EFATG's is being carried out by priority based on considerations of toxicity, production volume, and availability of specific emergency treatment information. Revisions of the emergency treatment information sections for the remaining profiles is underway and will be published as soon as they are completed. In the meantime, these profiles contain the emergency treatment information that was originally published in 1986. Because the emergency treatment information is designed for use by first responders, references to signs and symptoms of exposure as well as procedural guidance avoid the use of highly technical medical language. Signs and symptoms are not distinguished by route of exposure. Emergency treatment procedures, on the other hand, are presented according to route of exposure, with emphasis on the inhalation and dermal routes. References to invasive treatments are limited, since the emergency treatment information is directed to first responders rather than medical practitioners. First responders must be aware of particular state and local regulations which govern the extent of invasive treatment that they may perform. The Agency for Toxic substances and Disease Registry (ATSDR) has provided general review of the EFATf-'s for format and content. Comments. This section is provided, in some cases, to list the sources that were checked for information in cases of chemicals for which few data were available. In general, this section pertains to chemicals without TDB/HSDB files. Not Found. This statement on the profile can mean that: • The value or information was not found in the references used; • The value or information probably does not exist for this chemical; or • The value is meaningless or not applicable for this chemical. ------- -5- PERSONAL PROTECTIVE EQUIPMENT Personal protective equipment (PPE) for emergency response situations involving extremely hazardous substances must be selected carefully and used properly. The PPE should protect the respiratory system, skin, eyes, face, hands, feet and body from chemical, physical and biological hazards that may be encountered during an emergency response action. Selection of the proper personal protective equipment must consider the specific hazards responders are likely to encounter at a particular site. Selection is a complex task and should be performed only by individuals with proper training and experience. Regulatory Requirements and Other Standards. Selection, use, training and programs for PPE for emergency response situations may be covered by regulations and standards under the Occupational Safety and Health Administration (OSHA) 29 CFR 1910, Environmental Protection Agency (EPA) regulations and recommendations, Department of Transportation (DOT) regulations, or National Fire Protection Association (NFPA) standards. Personal Protective Equipment for Emergencies. During an emergency involving extremely hazardous substances, a wide variety of conditions may occur. Therefore, response personnel should wear maximum protection initially until actual conditions at the site are evaluated. Maximum protection is designed to provide the highest available level of respiratory, skin and eye protection. Recommended equipment consists of a positive pressure, pressure-demand full facepiece self-contained breathing apparatus (SCBA) or full facepiece supplied air respirator with escape SCBA and a fully-encapsulating chemical-resistant suit. In addition, other equipment such as inner chemical-resistant gloves, chemical-resistant safety boots/shoes, and two-way radio communications, a cooling unit, coveralls, long cotton underwear, hard hat, disposable gloves and boot covers may be worn as needed. Figure 1 gives an example of a worker outfitted in a fully- encapsulating suit with respiratory protection. Note that if the fully- encapsulating suit does not have integral gloves and boots, then glove/suit and boot/suit joints should be sealed with tape. Respiratory Protection. Positive pressure self-contained breathing apparatus (SCBA) should be worn by employees engaged in emergency response and exposed to hazardous substances until it is determined that a decreased level of respiratory protection will not result in hazardous exposures to employees (See OSHA 29 CFR 1910.120 Hazardous Waste Operations and Emergency Response). Chemical Protective Clothing and Equipment. The selection of chemical protective clothing is a complex process and many factors must be considered such as: the nature of the hazard; the potential route of exposure; the tasks to be accomplished; and the performance of the protective equipment materials in forming a barrier to the chemical substances encountered at a site. No protective equipment material protects against all chemicals and combinations of chemicals. In many cases, the chemical substance may permeate or break through the protective equipment;material, exposing the wearer to the chemical. It is important to note that the information ------- -6- Figure 1. FULLY ENCAPSULATING CHEMICAL-RESISTANT SUI Respiratory Protection Must be Worn with this Type of S From "Guidelines for the Selection of Chemical Protective C! 3rd Edition. ------- -7- presented for an individual chemical may not be applicable when that chemical is present in a mixture, as the ability of a chemical in a mixture to permeate a material may differ from that of the pure chemical. Further studies are needed to evaluate the characteristics of mixtures of chemicals in relation to materials for personal protective equipment. The chemical profiles give general information on the chemical resistance of various suit materials to provide a basis for a decision on whether suit materials are adequate. This information is available for about half of the chemicals on the list of extremely hazardous substances. The chemical resistance information for each suit material is indicated on the profiles by the entries shown below. Explanations of their meanings follow the entries. • Excellent Resistance/Many Data means there is quantitative information indicating that the material demonstrates excellent chemical resistance to the substance. • Good Resistance/Limited Data means there is quantitative information indicating that the material demonstrates good chemical resistance to the substance. • Poor Resistance/Many Data means there is quantitative information indicating that the material demonstrates poor chemical resistance to the substance. • Poor Resistance/Limited Data means there is quantitative information indicating that the material demonstrates poor chemical resistance to the substance. • Good Resistance/Limited Data* means there is qualitative information indicating that the material demonstrates good chemical resistance to the substance. Most of this information is based on qualitative ratings from glove material manufacturers and may or may not be based on actual testing. This entry on the profile is intended to provide general guidance in selecting chemical protective clothing. • Poor Resistance/Limited Data* means there is qualitative information indicating that the material demonstrates poor chemical resistance to the substance. Most of this information is based on qualitative ratings from glove material manufacturers and may or may not be based on actual testing. This entry on the profile is intended to provide general guidance in selecting chemical protective clothing. • Good Resistance/Limited Data** means there is qualitative or quantitative information indicating that the material demonstrates good chemical resistance based on the generic family of chemicals to which the substance belongs. Most of this information is not based on testing done on the substance itself. This entry on the profile is intended to provide general guidance to the initial selection of chemical protective clothing and to narrow the scope of alternative materials. ------- -8- • Poor Resistance/Limited Data** means there is qualitative or quantitative information indicating that the material demonstrates poor chemical resistance based on the generic family of chemicals to which the substance belongs. Most of this information is not based on testing done on the substance itself. This entry on the profile is intended to provide general guidance to the initial selection of chemical protective clothing and to narrow the scope of alternative materials. Remember that this information provides guidance only and is not a guarantee that the suit will protect an individual from prolonged or repeated exposure and may not provide adequate protection for mixtures of chemicals. Consult reference 1 for more information. Also, be sure to consult with facility representatives for additional information. Other considerations include durability and flexibility of the chemical protective clothing, and heat stress. Table 1 lists the fully-encapsulating suit materials available on the market as of February, 1987. (See non-mandatory Appendix B of OSHA 29 CFR 1910.120 for more information). Special Use Considerations. Fire, heat, explosion and radiation require special-protective equipment. It is important to provide protection from these hazards in addition to chemical hazards. Section IV of the profiles entitled Fire and Explosion Hazard Data should be consulted for further information. (See OSHA 29 CFR 1910.156, DOT and NFPA standards and recommendations for more information.) Decontamination. Decontamination of personal protective equipment should be tailored to the specific conditions at the site and will vary accordingly. (See non-mandatory Appendix D of OSHA 29 CFR 1910.120 for additional information). ------- -9- TABLE 1. AVAILABLE FULLY-ENCAPSULATING SUIT MATERIALS AS OF FEBRUARY, 1987* 1. Butyl Rubber/Nylon (BUTYL) 2. Butyl Rubber, Sheet (BUTYL) 3. Butyl/Fabric/Butyl (BUTYL) 4. Butyl/Nylon/Butyl (BUTYL) 5. Butyl/Polyester/Chloroprene Rubber (BUTYL/NEOPRENE) 6. Chlorinated Polyethylene (CPE) 7. Chlorobutyl Rubber/Nomex (CHLOROBUTYL) 8. Chlorobutyl/Nomex/Chlorobutyl (CHLOROBUTYL) 9. Chloroprene Rubber/Nylon (NEOPRENE) 10. Chloroprene Rubber, Sheet (NEOPRENE) 11. Fluoroelastomer/Butyl/Nylon/Butyl (VITON/BUTYL) 12. Fluoroelastomer/Fabric/Fluoroelastomer (VITON) 13. Fluoroelastomer/Nylon/Chloroprene (VITON/NEOPRENE) 14. Fluoroelastomer/Polyester/Chlorobutyl (VITON/CHLOROBUTYL) 15. Fluoroelastomer, Sheet (VITON) 16. Nitrile/Fabric (NITRILE) 17. PE/Polyvinylidenechloride/PE/Tyvek (SARANEX) 18. Polyethylene/Tyvek (PE) 19. Polyvinyl Chloride/Fabric (PVC) 20. Polyvinyl Chloride/Fabric/Polyvinyl Chloride (PVC) 21. Polyvinyl Chloride/Nylon (PVC) 22. Polyvinyl Chloride/Nylon/Polyvinyl Chloride (PVC) 23. Polyvinyl Chloride, Sheet (PVC) 24. Sontara (NONWOVEN FABRIC) 25. TFE/Fiberglass/TFE (TEFLON) 26. TFE/Nomex/TFE (TEFLON) 27. Tyvek (NONWOVEN PE) Schwope, A.D., et al. Guidelines for the Selection of Chemical Protective Clothing, 3rd Edition. Cincinnati: American Conference of Governmental Industrial Hygienists, Inc., 1987. ------- -10- PERSONAL PROTECTIVE EQUIPMENT REFERENCES 1.1 Schwope, A.D. ; P.P. Costas; J.O. Jackson; J.O. Stull; and D.J. Weitzman. Guidelines for the Selection of Chemical Protective Clothing. 3rd Edition. Cincinnati: American Conference of Governmental Industrial Hygienists, Inc., 1987. 2. Certified Equipment List as of October 1, 1986. DHHS (NIOSH) No. 87- 102. Cincinnati: National Institute for Occupational Safety and Health, 1986. 3. Criteria for a Recommended Standard ... Occupational Exposure to Hot Environments Revised Criteria 1986. DHHS (NIOSH) No. 86-113. Cincinnati: National Institute for Occupational Safety and Health, 1986. 4. National Institute for Occupational Safety and Health; Occupational Safety and Health Administration; U.S. Coast Guard; U.S. Environmental Protection Agency. Occupational Safety and Health Guidance Manual for Hazardous Waste Site Activities. DHHS Occupational Safety and Health, 1985. 5. Occupational Safety and Health Administration 29 CFR 1910 Occupational Safety and Health Standards, especially 29 CFR 1910.120 Hazardous Waste Operations and Emergency Response. 6. National Fire Protection Association standards and recommendations, such as NFPA 704M, 1500 and 1981. ------- -11- ABBREVIATIONS ACGIH ADI AIHA BAL GAS CC CNS EEC EEGL EKG EPA IARC ID1H 1m LCLO LC50 LDLO LD50 T,ET, m3 mg/Kg nnnHg NIOSH n.o.s. American Conference of Government and Industrial Hygienists Acceptable Daily Intake American Industrial Health Association Dimercaprol (British anti-lewisite) Chemical Abstracts Service Closed cup Central Nervous System Electroencephalogram Emergency Exposure Guidance Level developed by the National Research Council (NRC) Electrocardiogram Environmental Protection Agency International Agency for Research on Cancer Immediately Dangerous to Life and Health intramuscularly Lethal Concentration Low; the lowest concentration at which death occurred Lethal Concentration 50; the concentration at which 50% of the animals died; a calculated value Lethal Dose Low; the lowest dose at which death occurred Lethal Dose 50; the dose at which 50% of the animals died; a calculated value Lower Explosive Limit Cubic meter milligrams per kilogram millimeters of mercury; a measure of pressure National Institute of Occupational Safety and Health Not otherwise specified ------- NRG NTP OC OSHA PEL ppb ppm RBC RTECS SANSS SPEGL STEL TCC TOG TDLO TLV TWA DEL ug 2-PAM -12- ABBREVIATIONS (Confd) National Research Council, National Academy of Sciences National Toxicology Program open cup Occupational Safety and Health Administration Permissible Exposure Level parts per billion parts per million Red blood cell(s) Registry of Toxic Effects of Chemical Substances Structure and Nomenclature Search System Short-term Public Exposure Guidance Level developed by the NRC Short-term exposure limit Tagliabue Closed Cup, a standard method of determining flash point Tagliabue Open Cup, a standard method of determining flash point Toxic Dose Low; the lowest dose at which toxicity occurred Threshold Limit Value Time Weighted Average Upper Explosive Limit microgram pralidoxime ------- -13- GLOSSARY Acaricide Acidosis Acneform Albuminuria Alopecia Amorphous Anaphylactoid Anorexia Anoxia Anthelmintic Anticoagulant: Antilewisite Antimetabolite Antipyretic Aphasia Aplasia Ar gyrosis an agent that destroys mites pathologic condition resulting from accumulation of acid in, or loss of base from, the blood or body tissues resembling acne presence of serum albumin in the urine baldness; absence of hair from skin areas where it is usually present without definite form, not crystallized resembling an unusual or exaggerated allergic reaction to foreign protein or other substances lack or loss of appetite for food absence of lack of oxygen; reduction of oxygen in the body tissues below physiologic levels an agent that is destructive to worms especially of the intestine an agent that prevents blood clotting dimercaprol; also called British anti- lewisite, or BAL a substance that interferes with utilization of an essential metabolite an agent that relieves or reduces fever defect or loss of power of expression by or comprehension of speech, writing, or signs lack of development of an organ or tissue, or the cellular products from an organ or tissue; germinal aplasia -- complete failure of gonad development poisoning by silver or a silver salt, evidenced by ashen-gray discoloration of skin ------- -14- GLOSSARY (Cont'd) Arrhythmia Arteriosclerosis Asthenia Astringent Ataxis Avicide Bioaccumulation Bradycardia Bronchoconstriction Calcification Carcinogenic Cardiac Cathartic Cheyne -Stokes respiration Chloracne Clonic Conj unct ivitis Contraindication any variation from the normal rhythm of the heart beat hardening and thickening of the walls of the smaller arteries lack or loss of strength; weakness causing contraction, usually locally after surface application failure of muscular coordination; irregularity of muscular action an agent that kills birds increased concentrations of a chemical in an organism compared to the surrounding• environment slowness of the heart beat, as evidenced by slowing of pulse rate to less than 60 narrowing of the air passages of the lungs process by which organic tissue becomes hardened by a deposit of calcium salts within its substance producing or inciting cancer pertaining to the heart causing evacuation of the bowels; laxative respiratory distress related to posture (especially reclining at night) that occurs in association with heart disease acne-like eruption caused by exposure to chlorine compounds pertaining to alternate muscular contraction and relaxation in rapid succession inflammation of the lining of the eyelids any condition which renders some particular line of treatment improper or undesirable ------- -15- GLOSSARY (Cont'd) Cryogenic Cyanosis Decoction Demulcent Dermal Dermatitis Desiccant Diluent Diuresis Diuretic DS2 Ductile Dyspnea Ectoparasiticide Edema Ernesis Enteritis Epigastric Epileptiform Epithelium pertaining to or causing the production of low temperatures bluish discoloration, especially of the skin and mucous membranes and fingernail beds substance prepared by boiling soothing pertaining to the skin inflammation of the skin a drying agent a diluting agent increased secretion of urine agent that increases urine production standard decontaminant for chemical warfare agents; contains 70% diethylene triamine, 28% ethylene glycol monomethyl ether, and 2% sodium hydroxide capable of being drawn out or hammered thin difficult or labored breathing an agent that kills parasites living on the exterior of its host presence of abnormally large amounts of fluid in intercellular spaces of body tissues vomiting inflammation of the intestine pertaining to the upper-middle region of the abdomen occurring in severe or sudden spasms cells covering the internal and external surfaces of the body ------- -16- GLOSSARY (Cont'd) Erythema Exothermic Explosive Flammable Gastrointestinal Germinalaplasia Glomerular Half-life Halon Health Hazard Acute Chronic Delayed Hematoma Hematuria Hemoglohinuria Hemolysis Hemolytic Hepatic redness of the skin produced by congestion of the capillaries characterized by or formed with evolution of heat characterized by or relating to bursting forth with sudden violence or noise from internal energy; relating to a rapid reaction with production of noise, heat, and violent expansion of gases capable of being easily ignited and supporting combustion pertaining to the stomach and intestine lack of development of egg and sperm cells pertaining to a tuft or cluster, as of blood vessels or nerve fibers the time in which the concentration of a substance will be reduced by half halogenated hydrocarbon (e.g., carbon tetrachloride) immediate toxic effects persistent or prolonged injury toxic effect occurring after a lapse of time localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of the blood vessel blood in the urine presence of free hemoglobin in the urine separation of hemoglobin from red blood cells and its appearance in the plasma pertaining to or characterized by hemolysis pertaining to the liver ------- -17- GLOSSARY (Cont'd) Humectant Hydrolysis Hygroscopic Hyperactivity Hyperalimentation Hyperbilirubinemia Hypercalcemia Hyperparathyroidism Hyperpyrexia Hyperreflexia Hypersalivation Hypertens ion Hypervitaminosis Hypobilirubinemia Hypocalcemia Hypovolemic Hypoxemia Hypoxia Interstitial Pneumonia moistening or diluent substance decomposition reaction involving the splitting of a chemical substance by water readily taking up and retaining moisture (water) abnormally increased activity ingestion or administration of a greater than optimal amount of nutrients an excess of bilirubin in the blood excess of calcium in the blood abnormally increased activity of the parathyroid glands which affects and is affected by serum calcium levels a highly elevated body temperature exaggeration of reflexes excessive secretion of saliva persistently high arterial blood pressure condition due to ingestion of an excess of one or more vitamins abnormally low levels of bilirubin in the blood abnormal reduction of blood calcium levels pertaining to an abnormally decreased volume of circulating fluid (plasma) in the body deficient oxygenation of the blood low oxygen content or tension; deficiency of oxygen in the inspired air a chronic form of pneumonia with increase of the interstitial tissue and decrease of the proper lung tissue ------- -18- GLOSSARY (Cont'd) Isotonia Jaundice Lachrymator (or lacrimator) Lacrimation Laryngospasm Larynx Lassitude Latency Lesion Lethal Leukopenia Lewisite Malaise Mania Metastatic Methemoglobinemia Miosis (or myosis) a solution having the same effective osmotic pressure as the body fluid to which it is compared syndrome characterized by hyperbilirubinemia and deposition of bile pigment in the skin, resulting in yellow appearance of the patient a substance which increases the flow of tears secretion and discharge of tears spasmodic, closure of the larynx the muscular and cartilage structure situated at the top of the trachea (windpipe) and below the root of the tongue, functioning as sphincter into the trachea and as the organ of voice weakness; exhaustion a state of seeming inactivity a pathological or traumatic discontinuity of tissue or loss of function of a part deadly; fatal reduction in the number of leukocytes in the blood a lethal war gas which is a vesicant, lacrimator and lung irritant a vague feeling of bodily discomfort a phase of mental disorder characterized by an expansive emotional state, elation, overtalkativeness, and increased motor activity pertaining to the transfer of disease from one organ or part to another not directly connected with it presence of methemoglobin (oxidized hemoglobin) in the blood contraction of the pupil ------- -19- GLDSSARY (Cont'd) Miscible Mordant Mutagenic Mydriasis Myelosuppression Narcotic Necrosis Nephritis Neural Neuropathy Neurotoxicity Nocturia Ocular Oliguria Ophthalmic Osteosclerosis Palpitation Parasympathomimetic capable of mixing in any ratio without . separation of two phases a chemical that fixes a dye in or on a substance by combining with the dye to form an insoluble compound inducing genetic mutation extreme dilation of the pupil suppression of the formation of bone marrow an agent that produces insensibility or stupor death of tissue, usually as individual cells, group of cells, or in localized areas inflammation of the kidney pertaining to a nerve or to the nerves functional disturbances and/or pathological changes in the peripheral nervous system exerting a destructive or poisonous effect en nerve tissue excessive urination at night pertaining to or affecting the eye secretion of a diminished amount of urine in relation to fluid intake pertaining to the eye hardening or abnormal density of bone unduly rapid heart beat which is noted by the patient; it may be regular or irregular producing effects resembling time of stimulation of the parasympathetic nerve supply to a part; called also cholinergic ------- -20- GLOSSARY (Cont'd) Parenteral Paresthesia Perfusion Pharynx Photophobia Photosens itize Phytotoxic Polydipsia Precordial Proteinuria Psychosis Psychotropic Pulmonary Rales Recumbent Renal Scotoma not through the alimentary canal but rather by injection through some other route, such as subcutaneous, intramuscular, intravenous, etc. an abnormal sensation, as burning or prickling liquid poured over or through an organ or tissue the muscular membrane sac between the mouth and nostrils and the esophagus abnormal visual intolerance of light to induce a state of abnormal responsiveness to the influence of light poisonous to plants; inhibiting plant growth excessive thirst persisting for long periods of time pertaining to the region over the heart and lower part of the thorax an excess of serum proteins in the urine; also called albuminuria any major mental disorder characterized by derangement of the personality and loss of contact with reality exerting an effect upon the mind; capable of modifying mental activity pertaining to the lungs abnormal respiratory sound heard when listening for sounds within the body lying down pertaining to the kidney an area of depressed vision within the visual field, surrounded by an area of less depressed or normal vision ------- -21- GLOSSARY (Cont'd) Supertropical Bleach Systemic Tachycardia Tepid Teratogenic Tetanic Thrombocytopenia Tidal volume Tinnitus Toxic Triglyceridemia Urticaria Vasodilation Ventrictilar fibrillation Vertigo bleaching agent containing calcium hypochlorite (a powerful oxidizer) and calcium oxide (a corrosive material) pertaining to or affecting the body or organism as a whole excessively rapid heart beat moderately warm; lukewarm tending to produce anomalies of formation or development pertaining to or of the nature of tetanus, a disease characterized by muscle spasm decrease in the number of blood platelets amount of gas that is inhaled and exhaled during one respiratory cycle a noise in the ears, such as ringing, buzzing, roaring, clicking pertaining to, due to, or of the nature of a poison excess of triglycerides in the blood a vascular reaction of the skin marked by the transient appearance of smooth, slightly elevated patches (wheals) which are redder or paler than the surrounding skin and often attended by severe itching dilation (expansion of a vessel, especially of arterioles leading to increased blood flow to a part irregular heart beat characterized by uncoordinated contractions of the ventricle dizziness; an illusion of movement as if the external world were revolving around an individual or as if the individual were revolving in space Vesicant causing blisters ------- -22- GLOSSARY (Conf d) Volatile -- readily vaporizable at a relatively low temperature ------- -23- REFERENCES * Cited in TDB/HSDB file */- Cited in TDB/HSDB file and as a primary source /- Cited as a primary source /- ACGIH. 1986-87. American Conference of Governmental Industrial Hygienists. TLV threshold limit values in the work environment and biological exposure indices with intended changes for 1986-87. Cincinnati, Ohio: ACGIH. /- ACGIH. 1985. American Conference of Governmental Industrial Hygienists. TLV threshold limit values for chemical substances and physical agents in the work environment and biological exposure indices with intended changes for 1985-86. Cincinnati, Ohio: ACGIH. */- ACGIH. 1984. American Conference of Governmental Industrial Hygienists. TLV threshold limit values for chemical substances and physical agents in the work environment and biological exposure indices with intended changes for 1984-85. Cincinnati, Ohio: ACGIH. */- ACGIH. 1983. American Conference of Governmental Industrial Hygienists. TLV threshold limit values for chemical substances and physical agents in the work environment with intended changes for 1983- 1984. Cincinnati, Ohio: ACGIH. * ACGIH. 1982. American Conference of Governmental Industrial Hygienists. TLV threshold limit values for chemical substances and physical agents in the work environment with intended changes for 1982. Cincinnati, Ohio: ACGIH. * ACGIH. 1981. American Conference of Governmental Industrial Hygienists. TLV threshold limit values for chemical substances in workroom air adopted by ACGIH for 1981. Cincinnati, Ohio: ACGIH. */- ACGIH. 1980a. American Conference of Governmental Industrial Hygienists, Inc. Documentation of the threshold limit values, 4th ed., 1980. Cincinnati, Ohio: ACGIH. * ACGIH. 1980b. American Conference of Governmental Industrial Hygienists. TLVs threshold limit values for chemical substances in workroom air adopted by ACGIH for 1980. Cincinnati, Ohio: ACGIH. * ACGIH. 1979. American Conference of Governmental Industrial Hygienists. TLVs threshold limit values for chemical substances in workroom air adopted by ACGIH for 1979. Cincinnati, Ohio: ACGIH. * ACGIH. 1971-1979. American Conference of Governmental Industrial Hygienists. Documentation of the threshold limit values for substances in workroom air. Third edition, 1971. Cincinnati, Ohio: ACGIH. (Including supplements to 1979.) ------- -24- REFERENCES (Conf d) Agrochem Dept. Info. Service. 1971. AnthioSS insecticide, Sandoz Ltd. Basle, AGRO DDK E-4028/DG. American College of Neuropsychopharmacology. 1968. Psychopharmacology: review of progress, 1957-1967. Proceedings of the sixth annual meeting, Puerto Rico, December 12 to December 15, 1967. Washington, D.C.: U.S. Government Printing Office. Public Health Service Publication No. 1836. AHFS. 1984. American hospital formulary service. Vols. I and II. Washington, D.C.: American Society of Hospital Pharmacists, to 1984. AHFS. 1985. American hospital formulary service-drug information 85. Bethesda, MD: American Society Hospital Pharmacists. (Tentative listing) Aldrich. 1986. Catalog handbook of fine chemicals. Milwaukee: Aldrich Chemical Co. 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CRC handbook of analytical toxicology. Cleveland: The Chemical Rubber Company. Sunshine I, ed. 1975. Methodology for analytical toxicology. Cleveland: CRC Press, Inc. Talakina, ET et al. 1977. Protection of the health of pregnant women working in the production of acetylene-vinyl acetate, gig tr Prof Zabol volume 3. Testa B, Jenner P. 1976. Drug metabolism: chemical and biochemical aspects. New York. Marcel Dekker, Inc. Thienes C, Haley TJ. 1972. Clinical toxicology. 5th ed. Philadelphia: Lea and Febiger. Transdermal Indomethacin Pharmaceuticals. 1983 (May 13). Nitto Electric Industrial Co., Ltd., JPN Kokai Tokyo Koho Patent Number 83 79918. Tsubura Y, Kato Y (inventors), Kanesho Company, Limited (assignee). 1974 (August 15). Japan Kokai Patent Number 85233. ------- -39- REFERENCES (Cont'd) /- U.S. Army. 1975. Headquarters, Department of the Army. Military chemistry and chemical compounds. Washington, B.C.: Departments of the Army and the Air Force. U.S. Army Field Manual No. 3-9/Air Force Regulation No. 355-7. * Usdin E, Efron DH. 1972. Psychotropic drugs and related compounds. 2nd ed. Washington, D.C.: U.S. Government Printing Office, Department of Health, Education, and Welfare. Publication (HSM) 72-9094. * USEPA. 1983. U.S. Environmental Protection Agency. Tolerances for pesticide chemicals in or on raw agricultural commodities; certain pesticide chemicals. (48 FR 44205-6). * USEPA. 1980. U.S. Environmental Protection Agency. Ambient Water Quality Document: Endrin (EPA 440/4-80-047); Chloroform (EPA 44015-80- 033). * USEPA/ECAO. 1980. U.S. Environmental Protection Agency/Environmental Criteria and Assessment Office. Atlas document for phthalate. * USEPA/ODW. 1983. U.S. Environmental Protection Agency. Office of Drinking Water. Criteria document (draft): vinyl chloride p. III-l. /- USEPA/Pesticide Index. 1985. U.S. Environmental Protection Agency. EPA Index to Pesticide Chemicals: Use and Limitations. Current file; updated daily. Washington, D.C.: Office of Pesticide Programs, USEPA. /- USEPA/Active Ingredients. 1985. U.S. Environmental Protection Agency. EPA Chemical Index File: Active Ingredients. Current file; updated as needed. Washington, D.C.: Office of Pesticide Programs, USEPA. * USFWS. 1984. U.S. Fish and Wildlife Service, Department of the Interior. Handbook of toxicity of pesticides to wildlife. Washington, D.C.: U.S. Government Printing Office. Resource Publication 153. * USFWS. 1980. U.S. Fish and Wildlife Service, Department of the Interior. Handbook of acute.toxicity of chemicals to fish and aquatic invertebrates. Washington, D.C.: U.S. Government Printing Office. Resource Publication 137. * USFWS. 1975. U.S. Fish and Wildlife Service, Department of the Interior, Bureau of Sports Fisheries and Wildlife. Lethal dietary toxicities of environmental pollutants to birds. Washington, D.C.: U.S. Government Printing Office. Special Scientific Report -- Wildlife No. 191. * USFWS. 1972. U.S. Fish and Wildlife Service, Department of the Interior, Bureau of Sports Fisheries and Wildlife. Comparative dietary toxicities of pesticides to birds. Washington, D.C.: U.S. Government Printing Office. Special Scientific Report -- Wildlife No. 152. ------- -40- REFERENCES (Confd) *-. USFWS. 1970. U.S. Fish and Wildlife Service, Department of the Interior. Handbook of toxicity of pesticides to wildlife. Washington, D.C.: U.S. Government Printing Office. * Venugopal B, Luckey TD. 1978. Metal toxicity in mammals, 2. New York: Plenum Press. */- Verschueren K. 1983. Handbook of environmental data on organic chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold Company. * Wagoner JK. 1983. Environ health perspect 52. * Weast RC, ed. 1984. Handbook of chemistry and physics. 65th ed. Boca Raton, FL: CRC Press, Inc. */- Weast RC, ed. 1983. Handbook of chemistry and physics. 64th ed. 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Hazardous chemicals data book. Park Ridge, NJ: Noyes Data Corporation. * Weiss, RB and FM Muggia. 1980. American Journal of Medicine 68(2):259. * White-Stevens R, ed. 1976a. Pesticides in the environment: Vol 3. New York: Marcel Dekker. ------- -41- REFERENCES (Conf d) * White-Stevens R, ed. 1976b. Pesticides in the environment: Vol 2. New York: Marcel Dekker. * White-Stevens R, ed. 1971. Pesticides in the environment: Vol 1. Part 1, Part 2. New York: Marcel Dekker. */- Worthing CR, Walker SB, eds. 1983. The pesticide manual -- a world compendium. 7th ed. Lavenham, Suffolk, Great Britain: The Lavenham Press Limited. *. Worthing CR, ed. 1979. Pesticide manual. 6th ed. Worcestershire, England: British Crop Protection Council. /- Worthy-W. 1985. Methyl isocyanate: the chemistry of a hazard. Chem Eng News 63(6):27-33. ------- ------- CAS Registry Number: 50-00-0 Page 5 of 5 FORMALDEHYDE SECTION VIII (continued) SUIT MATERIAL.PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl EXCELLENT/MANY Butyl/Neoprene GOOD/LIMITED* CPE GOOD/LIMITED Neoprene POOR/MANY Nitrile POOR/MANY PE EXCELLENT/MANY PVC POOR/MANY Teflon POOR/LIMITED Viton EXCELLENT/MANY Viton/Neoprene GOOD/LIMITED* *Based on qualitative performance information. **Based on a chemical analog. NOTES: For concentrations <37% formaldehyde SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 50-00-0 Page 1 of 3 Emergency First Aid Treatment Guide for FORMALDEHYDE (50-00-0) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Colorless gas or liquid below -20 degrees C (-6 degrees F). Odor - Strong, pungent. Commercial Form - Aqueous solution containing approximately 40% formaldehyde and 15% methanol. Uses - Disinfectant, preservative, embalming fluid, treatment of grain smut, hardening agent, reducing agent, corrosion inhibitor, gold and silver recovery, textile manufacture. Other Names - Formalin, formic aldehyde, Formol, Karsan, Lysoform, methanal, methyl aldehyde, methylene oxide, Morbicid, oxomethane, oxymethylene. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, sodium bicarbonate, dopamine, norepinephrine, levarterenol. ------- EFATG CAS Registry Number: 50-00-0 Page 2 of 3 FORMALDEHYDE Signs and Symptoms of Acute Formaldehyde Exposure: Acute exposure to formaldehyde may result in irritation or burns to the skin, eyes, and mucous membranes; lacrimation (tearing); nausea; vomiting (may be bloody); abdominal pain; and diarrhea. Difficulty in breathing, cough, pneumonia, and pulmonary edema may occur. Sensitized people may experience asthmatic reactions, even when exposed briefly. Hypotension (low blood pressure) and hypothermia (reduced body temperature) may precede cardiovascular collapse. Lethargy, dizziness, convulsions, and coma may be noted. Nephritis (inflammation of the kidneys), hematuria (bloody urine), and liver toxicity have been reported. Emergency Life-Support Procedures: Acute exposure to formaldehyde may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to formaldehyde. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to formaldehyde. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least IS minutes. ------- EFATG CAS Registry Number: 50-00-0 Page 3 of 3 FORMALDEHYDE 5. Wash exposed skin areas twice with soap and water, 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of formaldehyde is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 5. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of formaldehyde may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 5. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities'of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 7. Transport to a health care facility. ------- CAS Registry Number: 50-07-7 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- MITOMYCIN C CAS Registry Number: 50-07-7 Synonyms: Ametycine; Mutamycin; NSC-26980; Azirino[2',3':3,4]pyrrolo [l,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-l,la,2,8,8a,8b- hexahydro-8a-methoxy-5-methyl-,[laR-(la.alpha.,8.beta.,8a.alpha.,8b.alpha.)]- Chemical Formula: C15H18N4O5 Molecular Weight: 334.37 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 14 rag/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory); 10 (pounds) (proposed) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: Above 680°F, 360°C (*Merck 1983) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (*Merck 1983) Appearance and Odor: Blue-violet crystals (*Merck 1983) ------- CAS Registry Number: 50-07-7 Page 2 of 3 MITOMYCIN C i SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Not Found Health Hazards (Acute, Delayed, and Chronic): Toxic doses as low as 750 rag/kg have been reported in humans (*NIOSH 1979). The major toxic effect is myelosuppression, characterized by marked leukopenia and thrombocytopenia; this may be delayed and cumulative. Interstitial pneumonia and glomerular damage resulting in kidney failure are unusual but well documented complications (Oilman 1985, p. 1289). Medical Conditions Generally Aggravated by Exposure: Lung conditions — administration of mitomycin has been recognized as causing pneumonitis, alveolitis and pulmonary fibrosis (*Weiss 1980). Kidney conditions -- administration of mitomycin can cause kidney damage (Oilman 1985, p. 1289). Kidney toxicity was observed in 1-5 percent of patients. Depressed immune conditions (*AMA 1977). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found - Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found ------- CAS Registry Number: 50-07-7 Page 3 of 3 MITOMYCIN C SECTION V (continued) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Anti-tumor antibiotic complex (*Merck 1976). This drug is usually injected intravenously (*AMA 1977). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation and skin contact. SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Headaches, blurred vision, confusion, drowsiness, fatigue, diarrhea, and pain have been occasionally noted. These do not appear to be dose related by intravenous administration. Fever and anorexia occur in 15 percent of patients. Hair loss, sloughing of skin, and loss of feeling occur in approximately 4 percent of patients. Labored breathing, cough and pneumonia occur in some cases. Renal toxicity is sometimes observed (*AMA 1977). Emergency and First Aid Procedures: Seek immediate medical care. Skin decontamination should be thorough, with water and soap. Eye exposure can be followed by irrigation of eyes with plain tap water (*Rumack 1975 to Present). (Non-Specific - Medicines, n.o.s.) If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature (DOT 1984, Guide 11). ------- CAS Registry Number: 50-14-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ERGOCALCIFEROL CAS Registry Number: 50-14-6 Synonyms: 9,10-Secoergosta-5,7,10(19),22-Tetraen-3-beta-ol; 9,10-Secoergosta-5,7,10( 19),22-Tetraen-3-ol,(3-beta,5Z,7E,22E)-; Activated Ergosterol; Buco-D; Calciferol; Calciferon 2; Condacaps; Condocaps; Condol; Crtron; Crystallina; D-Arthin; D-Tracetten; Daral; Davitamon D; Davitin; De-Rat Concentrate; Decaps; Dee-Osterol; Dee-Ron; Dee-Ronal; Dee-Roual; Deltalin; Deratol; Detalup; Diactol; Divit Urto; Doral; Drisdol; Ergorone; Ergosterol Activated; Ergosterol, Irradiated; Ertron; Fortodyl; Geltabs; Hi-Deratol; Infron; Irradiated Ergosta-5,7,22-Trien- 3-Beta-ol; Irradiated Ergosterol; Metadee; Mina D2; Mulsiferol; Mykostin; Oleovitamin D; Oleovitamin D2; Ostelin; Radiostol; Radsterin; Shock-Ferol; Vitamin D2 Chemical Formula: C28H44O Molecular Weight: 396.63 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDlow oral (dog) 4 mg/kg (*NIOSH/RTECS 1985) TPQ: 1,000/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 239-244°F, 115-118°C (*Merck 1976) Vapor Density (AIR=1): Not Found ------- CAS Registry Number: 50-14-6 Page 2 of 4 ERGOCALCIFEROL SECTION II (continued) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble in water (*Merck 1976) Appearance and Odor: White crystals, odorless (*Osol 1975) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (*Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): Ergocalciferol poisoning disturbs calcium metabolism and causes kidney damage (Buchel 1983, p. 224). Ergocalcif erol in a single acute ingestion presents no toxic hazards. Daily ingestion in excess of 5000 units/day in children or 7500 units/day in adults will produce toxic symptoms associated with hypervitaminosis D (*Rumack 1975 to Present). Medical Conditions Generally Aggravated by Exposure: Those with hypercalcemia are at a greater risk (Physicians' Desk Reference 1985, p. 1748) SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Medicines, n.o.s.) Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 11). Special Fire Fighting Procedures: (Non-Specific — Medicines, n.o.s.) Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out (DOT 1984, Guide 11). Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found ------- CAS Registry Number: 50-14-6 Page 3 of 4 ERGOCALCIFEROL SECTION V -- REACTIVITY DATA Stability: Unstable: Yes (*Furia 1972) Stable: Conditions to Avoid: Shows signs of decomposition when stored for a few days at room temperature (*Furia 1972). Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Nutrient and/or dietary supplement food additive (*Sax 1975). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Medicines, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Shut off ignition sources; no flares, smoking or flames in hazard area. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch spilled material. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 11). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Initial symptoms of ergocalciferol poisoning include anorexia, nausea and vomiting. It often mimics hyperparathyroidism with thirst, muscular weakness, nervousness, kidney impairment, hypertension (*Gosselin 1976), and excessive urination (*Gilman 1980). ------- CAS Registry Number: 50-14-6 Page 4 of 4 ERGOCALCIFEROL SECTION IX (continued) Emergency and First Aid Procedures: (Non-Specific — Medicines, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature (DOT 1984, Guide 11). ------- CAS Registry Number: 50-00-0 Page 3 of 5 FORMALDEHYDE SECTION IV (continued) UEL: 73% (*Sax 1975) Extinguishing Methods: Small fires: dry chemical, carbon dioxide, water spray or foam. Large fires: water spray, fog or foam. Move container from fire area if you can do so without risk. Do not get water inside container. Spray cooling water on containers exposed to flames until well after fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire (DOT 1984, Guide 29). Special Fire Fighting Procedures: Keep unnecessary people away; stay upwind; keep out of low areas. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire (*DOT 1984). Wear self-contained breathing apparatus; wear goggles if eye protection not provided. Shut off flow of gas or liquid and keep cooling water streams on exposed tanks or containers. Use water spray carefully in vicinity of dusts so as not to create dust clouds (*NFPA 1978). Unusual Fire and Explosion Hazards: Toxic vapors such as carbon dioxide and carbon monoxide are generated during combustion (*Environment Canada 1982). Explosion hazard: when aqueous formaldehyde solutions are heated above their flash points, a potential for explosion hazard exists. High formaldehyde concentration or methanol content lowers flash point. Reacts with nitrogen oxides at about 180; the reaction becomes explosive. Also reacts violently with perchloric acid-aniline, performic acid, nitromethane, magnesium carbonate, and hydrogen peroxide (Sax 1984, p. 1452). NFPA Flammability Rating: 4 (gas); 2 (37% solution) SECTION V -- REACTIVITY DATA Stability: Unstable: Yes, aqueous solutions (*Lefaux 1968) Stable: Yes, commercial formaldehyde-alcohol solutions (*Kirk-Othmer 1978); gas is stable in absence of water (*HeaIth and Safety Executive Monograph 1981) Conditions to Avoid: Oxidizing and alkaline materials (*NFPA 1978) Incompatibility (Materials to Avoid): Reacts with peroxide, nitrogen oxide, and performic acid causing explosions (*Environment Canada 1982). Can react with hydrogen chloride or other inorganic chlorides to form bis-chloromethylether (BCME), a known carcinogen (*General Electric Co. 1981, MSDS 360). Very reactive, combines readily with many substances, 40% solution is powerful reducing agent (*Merck 1976). Incompatible with amines, azo compounds, dithiocarbamates, alkali and alkaline earth metals, nitrides, nitro compounds, unsaturated aliphatics and sulfides, organic peroxides, oxidizing agents, and reducing agents (*Environment Canada 1982). Hazardous Decomposition or Byproducts: When heated, irritant formaldehyde gas evolved from solution (Sax 1984, p. 1452). The main products of ------- CAS Registry Number: 50-00-0 Page 4 of 5 FORMALDEHYDE SECTION V (continued) decomposition are carbon monoxide and hydrogen. Metals such as platinum, copper, chromia, and alumina also catalyze the formation of methanol, methylformate, formic acid, carbon dioxide, and methane (*Kirk- Othmer 1978). Hazardous Polymerization: May Occur: Yes (*Environment Canada 1982) May Not Occur: Conditions to Avoid: Compound will polymerize with active organic materials such as phenol (*General Electric Co. 1981, MSDS 360). Will polymerize violently in the presence of caustics and nitrides; (amines) exothermic reaction, (Azo compound) exothermic reaction giving off nitrogen gas, (caustics) heat generation and violent polymerization, (dithiocarbamates) formation of flammable gases and toxic fumes, formation of carbon disulfide may result, (alkali and alkaline earth metals) heat generation and formation of a flammable hydrogen gas (*Environment Canada 1982). SECTION VI - USE INFORMATION Urea and melamine resins; polyacetal resins; phenolic resins; ethylene glycol; pentaerythritol; hexamethylenetetramine; fertilizer; dyes, medicine (disinfectant, germicide); embalming fluids; preservative; hardening agent; reducing agent, as in recovery of gold and silver; corrosion inhibitor in oil wells; durable-press treatment of textile fabrics; possible condensation to sugars and other carbohydrates for food use (experimental); industrial sterilant; treatment of grain smut (Hawley 1977, p. 395). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors; do not get water inside container. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 29). Use fluorocarbon water spray, Cellosize, and Hycar to diminish vapors. Use sodium carbonate, ammonium hydroxide or sodium sulfite to neutralize spill. Use universal gel, fly/ash, universal sorbent material, or cement powder to absorb the spill (*Environment Canada 1982). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 50-00-0 Page 1 of 5 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- FORMALDEHYDE CAS Registry Number: 50-00-0 Synonyms: BFV; FA; Fannoform; Formaldehyde solution; Formaldehyde, as Formalin solution (DOT); Formaldehyde, gas; Formalin; Formalin 40; Formalith; Formic Aldehyde; Formol; Fyde; Hoch; Ivalon; Karsan; Lysoform; Methanal; Methyl Aldehyde; Methylene Glycol; Methylene Oxide; Morbicid; NCI-C02799; Oxomethane; Oxymethylene; Superlysoform Chemical Formula: CH2O Molecular Weight: 30.03 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 500 (pounds) RQ: 1,000 (pounds) (statutory); 100 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Gas Boiling Point: -3.1°F, -19.5°C at 760 mmHg (*Merck 1976); commercial aqueous formaldehyde boils at 205°F, 96°C (Merck 1983, p. 604) Specific Gravity (H2O=1): 1.067 (*Merck 1976); 0.815 at -20°C/4°C for anhydrous form (Merck 1983, p. 604) Vapor Pressure (mmHg): 10 at -88°C (*Patty 1963), for anhydrous form Melting Point: -134°F,-92°C (*Merck 1976), for anhydrous form Vapor Density (AIR=1): 1.03 for aqueous solution; 1.075 for gas (*Environment Canada 1982), 1.067 for gas (Merck 1983, p. 604) ------- CAS Registry Number: 50-00-0 Page 2 of 5 FORMALDEHYDE SECTION II (continued) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Very soluble in water, up to 55% (*Merck 1976) Appearance and Odor: Gas or liquid, strong, pungent odor, clear, water-white (Sax 1984, p. 145). SECTION III -- HEALTH HAZARD DATA OSHA PEL: TWA 3 ppm; Ceiling Concentration 5 ppm; Peak Concentration 10 ppm/30 minutes/8 hours (*NIOSH/RTECS 1985) ACGIH TLV: TWA 1.5 mg/ms (1 ppm) (*ACGIH 1980); STEL 3 mg/ms (2 ppm) (ACGIH 1986-87, p.19) IDLH: 100 ppm (NIOSH/OSHA 1978, p. 104) Other Limits Recommended: Occupational exposure to formaldehyde recommended standard -- air ceiling concentration 1.2 mg/m3/30 minutes (*NIOSH/RTECS 1985). Industrial substance suspect of carcinogenic potential for humans recommended standard 1 ppm (ACGIH 1984, p. 42) Routes of Entry: Inhalation: Yes (Proctor and Hughes 1978, pp. 272-273) Skin: Yes (Environment Canada 1982) Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): The probable oral lethal dose for humans is 0.5-5 g/kg, or between 1 ounce and 1 pint for a 150 pound person (*Gosselin 1976). Acute -- below 1 ppm, odor perceptible to most. 2-3 ppm, mild tingling of eyes. 4-5 ppm, increased discomfort, mild lacrimation. 10 ppm, profuse lacrimation; can be withstood only for few minutes. 10-20 ppm, breathing difficult, cough, severe burning of nose and throat. 50-100 ppm, acute irritation of respiratory tract, very serious injury likely. Skin — primary irritation from strong solutions, gas. Delayed — sensitization dermatitis (Proctor and Hughes 1978, pp. 272-273). Suspected carcinogen (*Kirk-Othmer 1978). Effects in women include menstrual disorders and secondary sterility (*IARC 1972-1985). Solutions splashed in eyes have caused injuries ranging from severe, permanent corneal opacification and loss of vision to minor discomfort (*Grant 1974). Medical Conditions Generally Aggravated by Exposure: In people sensitized to formaldehyde, late asthmatic reactions may be provoked by brief exposures at approximately 3 ppm (*Hendrick 1982). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 60°C/40% solution (*Merck 1976) Flammable Limits: LEL: 7% (*Sax 1975) ------- CAS Registry Number: Not Found Page 3 of 3 ORGANORHODIUM COMPLEX SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Catalyst (PMN-82-147). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Poisonous Solid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Do not touch spilled material; stop leak if you can do it without risk. Small spills: take up with sand or other non-combustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Not Found Emergency and First Aid Procedures: (Non-Specific -- Poisonous Solid, n.o.s.) Move victim to fresh air; call emergency medical care. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes (DOT 1984, Guide 55). ------- CAS Registry Number: Not Found Premanufacture Notice Number: PMN-82-147 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- GENERIC NAME: ORGANORHODIUM COMPLEX (This chemical was identified from a Premanufacture Review Notice (PMN) submitted to EPA. The submitter has claimed certain information on the submission to be confidential, including specific chemical identity, chemical formula, and molecular weight.) CAS Registry Number: Not Found Synonyms: Not Found Chemical Formula: Not Found Molecular Weight: Not Found SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.08 mg/liter (submitter's estimate) (PMN-82-147) TPQ: 10/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (PMN-82-147) ------- CAS Registry Number: Not Found Page 2 of 3 ORGANORHODIUM COMPLEX SECTION II (continued) Appearance and Odor: Green crystals (PMN-82-147) SECTION III -- HEALTH HAZARD DATA OSHA PEL: (Rhodium metal fume dust) 0.1 mg/ms, as rhodium (NIOSH 1987, p. 204) ACGIH TLV: (Insoluble Rhodium Compounds) TWA 1 mg/m3, as rhodium (A( 1984, p. 29) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Not Found Health Hazards (Acute, Delayed, and Chronic): (Non-Specific — Organometals) Organometals may be highly toxic orally. They are irritating to skin, eyes, and mucous membranes. They can damage lung tissue and the liver (Sax 1984, p. 2095). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Poisonous Solid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog or foam. Move container from fire area if you can do it without risk (DOT 1984, Guide 53). Special Fire Fighting Procedures: (Non-Specific « Poisonous Solid, n.o.s.) Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing (DOT 1984, Guide 53). Unusual Fire and Explosion Hazards: (Non-Specific -- Poisonous Solid, n.o.s.) Fire may produce irritating or poisonous gases (DOT 1984, Guide 53). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 51-21-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- FLUOROURACIL CAS Registry Number: 51-21-8 Synonyms: Uracil, 5-Fluoro-; 5-Fluorouracil; Efudex; Fluoroplex; 2,4-Dioxo-5-Fluoropyrimidine; 5-Fluoro-2,4( 1 H,3H)-Pyrimidinedione; 5-Fluoro- 2,4-Pyrimidinedione; 5-Fluoropyrimidine-2,4-Dione; 5-Fluoropyrimidine- 2,4-Dione; Fluoro Uracil; Fluracil; Fluril; FU; 5-FU; NSC 19893; RO 2-9757; U-8953; 2,4(1 H,3H)-Pyrimidinedione, 5-Fluoro- Chemical Formula: C4H3FN2O2 Molecular Weight: 130.08 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rabbit) 18.9 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: Decomposes at 540-541°F, 282-283°C (*Merck 1976) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1 g in 80 mL of water (*Osol 1975) ------- CAS Registry Number: 51-21-8 Page 2 of 4 FLUOROURACIL SECTION II (continued) Appearance and Odor: White to practically white crystalline powder; practically odorless (*Osol 1975) SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Yes (Physicians' Desk Reference 1980, p. 1452) Ingestion: Yes (*Goodman 1975) Health Hazards (Acute, Delayed, and Chronic): Minimum toxic dose in humans is approximately 450 mg/kg (total dose) over 30 days for the ingested drug. Intravenous minimum toxic dose in humans is a total dose of 6 mg/kg over three days. Depression of white blood cells occurred after intravenous administrative of a total dose of 480 mg/kg over 32 days (*NIOSH/RTECS 1978). Medical Conditions Generally Aggravated by Exposure: Occasional neuropathy and cardiac toxicity have been reported (Oilman 1985, pp. 1270-1271). Do not use during pregnancy (Physicians' Desk Reference 1980, p. 1455). Patients with impaired hepatic or renal function, with a history of high-dose pelvic irradiation or previous use of alkylating agents should be treated with extreme caution (Physicians' Desk Reference 1980, p. 1455). Patients with nutritional deficiencies and protein deple- tion have a reduced tolerance to fluorouracil (Oilman 1985, p. 1270). SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific -- Drugs or Medicines, n.o.s. (Solid) Poison B) Extinguish fire using agent suitable for type of surrounding fire (material itself burns with difficulty). Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical (Student 1981, p. 215). Special Fire Fighting Procedures: (Non-Specific ~ Drugs or Medicines, n.o.s. (Solid) Poison B) Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Wear ------- CAS Registry Number: 51-21-8 Page 3 of 4 FLUOROURACIL SECTION IV (continued) boots, protective gloves, and goggles. Wear self-contained breathing apparatus (Student 1981, p.-215). Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Osol 1975) Conditions to Avoid: Decomposing heat (*Merck 1976) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Emits very toxic fumes of flourides and nitrogen oxides when heated to decomposition (Sax 1984, p. 1450). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Antineoplastic drug (*Merck 1976); chemosterilant for insects (*White-Stevens 1976). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Drugs) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. If water pollution occurs, notify appropriate authorities. Spill or leak: shut off ignition sources; no flares, smoking or flames in hazard area. Keep combustibles (wood, paper, oil etc.) away from spilled material. Do not touch spilled material. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 11). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- ------- CAS Registry Number: 51-21-8 Page 4 of 4 FLUOROURACIL SECTION VIII (continued) demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Loss of appetite and nausea are earliest symptoms, with other symptoms of diarrhea, inflammation or sores in the mouth, gastric burning, and intestinal discomfort. More serious symptoms are due to the suppression of bone marrow, with decrease of white cell count and blood platelets, and anemia. Hair loss, nail changes, dermatitis, and pigmentation and atrophy of skin also occur (*Goodman 1975). Emergency and First Aid Procedures: (Non-Specific -- Drugs) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature (DOT 1984, Guide 11). ------- CAS Registry Number: 51-75-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- MECHLORETHAMINE CAS Registry Number: 51-75-2 Synonyms: 2,2'-Dichloro-N-Methyldiethylamine; 2-Chloro-N-(2-Chloroethyl)- N-Methylethanamine; Beta,Beta'-Dichlorodiethyl-N-Methylamine; Bis(2-Chloro- ethyl)Methylamine; Bis(Beta-Chloroethyl)Methylamine; Caryolysin; Chloramine (the nitrogen mustard); Chlorethazine; Chlormethine; Di(2-Chloroethyl) Methylamine; Dichlor Amine; Diethylamine, 2,2'-Dichloro-N-Methyl-; Embichin; ENT-25294; Ethanamine, 2-Chloro-N-(2-Chloroethyl)-N-Methyl-; HN2; MBA; Methylbis(2-Chloroethyl)Amine; Methylbis(Beta-Chloroethyl)Amine; Methylbis (Chloroethylamine); Methyldi(2-Chloroethyl)Amine; Mustargen; Mustine; N,N-Bis(2-Chloroethyl)methylamine; N,N-Di(Chloroethyl)Methylamine; N-Methyl-2,2'-Dichlorodiethylamine; N-Methyl-bis(2-Chloroethyl)Amine; N-Methyl-Bis(Beta-Chloroethyl)Amine; N-Methylbis(2-Chloroethyl)Amine; N-Methylbis(Beta-Chloroethyl)Amine; Nitrogen Mustard; NSC 762; TL 146 Chemical Formula: C5HUC12N Molecular Weight: 156.07 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 skin (rat) 14 mg/kg (*NIOSH/RTECS 1985) TPQ: 10 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 189°F, 87°C at 18 mmHg (*Merck 1976) Specific Gravity (H2O=1): 1.118 at 25°C/4°C (*Merck 1976) Vapor Pressure (mmHg): Not Found Melting Point: -76°F, -60°C (*Merck 1976) ------- CAS Registry Number: 51-75-2 Page 2 of 4 MECHLORETHAMINE SECTION II (continued) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Very slightly soluble (*Merck 1976) Appearance and Odor: Mobile liquid; faint odor of herring (*Merck 1976). SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Gilman 1980) Skin: Yes (*Gilman 1980) Ingestion: Yes (*Gilman 1980) Health Hazards (Acute, Delayed, and Chronic): Toxic doses as low as 400 mg/kg have been reported in humans (*NIOSH/RTECS 1985). Blood clots may occur at site of intravenous injection and tissue damage if outside vein. Powerful vesicant (causes blisters) when it contacts skin, mucous membranes, or eyes. Delayed toxicity ~ missed menstrual periods, alopecia (hair loss), hearing loss, tinnitus (ringing in ears), jaundice, impaired spermatogenesis and germinal aplasia, swelling, and hypersensitivity (*Gilman 1980). Medical Conditions Generally Aggravated by Exposure: May damage fetus in pregnant women (*Gilman 1980). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific -- Poisonous Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific — Poisonous Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). ------- CAS Registry Number: 51-75-2 Page 3 of 4 MECHLORETHAMINE SECTION IV (continued) Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Yes (*Merck 1976) Stable: Conditions to Avoid: Undiluted liquid decomposes on standing (*Merck 1976) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI « USE INFORMATION Drug used in treatment of cancer (*Gilman 1980). Formerly used as a gas warfare agent (*Merck 1976). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Poisonous Liquid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 51-75-2 Page 4 of 4 MECHLORETHAMINE SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) Chemical Resistance/Amount of Data) Viton GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX ~ EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Nausea and vomiting; bleeding; skin lesions; menstrual irregularities (*Gilman 1980). Emergency and First Aid Procedures: Treat symptoms using procedures for general poison (*Rumack 1975 to Present). (Non-Specific -- Poisonous Liquid, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 51-83-2 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- CARBACHOL CHLORIDE CAS Registry Number: 51-83-2 Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 917) Choline, Chloride, Carbamate; Carbachol; Carbacholin; Carbacholine; Carbacholine Chloride; Carbacolina; Carbamic Acid, Ester with Choline Chloride; Carbaminocholine Chloride; Carbaminoylcholine Chloride; Carbamiotin; Carbamoylcholine Chloride; gamma-Carbamoyl Choline Chloride; Carbamoylcholine-Hydrochloride; Carbamylcholine Chloride; Carbochol; Carbocholin; Carbocholine; Carbyl; Carcholin; Choline Carbamate Chloride; Choline, Chloride Carbamate(Ester); Choline Chloride, Carbamoyl-; Choline Chlorine Carbamate; Coletyl; Doryl; Doryl (Pharmaceutical); Ethanaminium, 2-((Aminocarbonyl)oxy)-N,N,N-Trimethyl-, Chloride; (2-Hydroxyethyl)Trimethyl Ammonium Chloride Carbamate; Isopto Carbachol; Jestryl; Lentin; Miostat; Mistura C; Moryl; P.V. Carbachol; TL 457; Vasoperif Chemical Formula: C6H15N2O2C1 Molecular Weight: 182.68 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mouse) 15 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 392-401°F, 200-205°C (Merck 1983, p. 245) ------- CAS Registry Number: 51-83-2 Page 2 of 3 CARBACHOL CHLORIDE SECTION II (continued) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1 g/mL (Merck 1983, p. 245) Appearance and Odor: Crystalline, odorless, but on standing in an open container, develops a faint odor resembling that of an aliphatic amine (Merck 1983, p. 245); hygroscopic prisms or powder (Weast 1979, p. C-246) SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Yes (Sax 1984, p. 631) Ingestion: Yes (Sax 1984, p. 631) Health Hazards (Acute, Delayed, and Chronic): Highly toxic by mouth (Sax 1984, p. 631). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: The aqueous solution is stable even when heated (Merck 1983, p. 245). ------- CAS Registry Number: 51-83-2 Page 3 of 3 CARBACHOL CHLORIDE SECTION V (continued) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits very toxic fumes of chloride and nitrogen oxides (Sax 1984, p. 631). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Cholinergic; parasympathomimetic, used chiefly in large animals, especially for colic in the horse (Merck 1983, p. 245) SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid skin contact (see Section III above). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles foi additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Not Found Emergency and First Aid Procedures: Not Found COMMENTS Sources searched but no information found: DOT 1984 Farm Chemicals Handbook 1984 Oilman 1985 Hayes 1982 Gosselin 1984 Buchel 1983 Clayton and Clayton 1981-82 Hawley 1981 ------- CAS Registry Number: 54-11-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- NICOTINE CAS Registry Number: 54-11-5 Synonyms: (-)-3-(l-Methyl-2-Pyrrolidyl)Pyridine; l-Methyl-2-(3-Pyridyl) Pyrrolidine; beta-Pyridyl-alpha-N-Methylpyrrolidine; Destruxol Orchid Spray; EMO-NIK; ENT 3,424; Flux Maag; Fumetobac; L-3-(l-Methyl-2-Pyrrolidyl)Pyridine; L-Nicotine; Mach-Nic; Niagara PA Dust; Nic-Sal; Nico-Dust; Nico-Fume; Nicocide; Nicotin; Nicotine Alkaloid; Ortho N-4 Dust; Ortho N-5 Dust; Pyridine, 3-(l-Methyl-2-Pyrrolidinyl)-, (S)-; Pyridine, 3-(Tetrahydro- l-Methylpyrrol-2-yl); Pyrrolidine, l-Methyl-2-(3-Pyridyl)-; Tendust; Tetrahydronicotyrine, DL- Chemical Formula: C10H14N2 Molecular Weight: 162.23 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Not Found TPQ: 100 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 476.1°F, 246.7°C at 745 mmHg (*Weast 1979) Specific Gravity (H2O=1): 1.0097 at 20°C/4°C (*Merck 1983) Vapor Pressure (mmHg): 1 at 61.8°C (Sax 1984, p. 1997) Melting Point: -110°F, -79°C (*Weast 1979) Vapor Density (AIR=1): 5.61 (Sax 1984, p. 1997) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Miscible below 60°C (*Merck 1983) ------- CAS Registry Number: 54-11-5 Page 2 of 4 NICOTINE SECTION II (continued) Appearance and Odor: Colorless to pale yellow, oily liquid (*Merck 1983). Slight, fishy odor when warm (NIOSH/OSHA 1978, pp. 138-139). SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.5 mg/ms (*NIOSH/RTECS 1985) ACGIH TLV: TWA 0.5 mg/ms (skin) (*ACGIH 1983) IDLH: 35 mg/ms (NIOSH/OSHA 1978, p. 138-139) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Sax 1984, p. 1997) Skin: Yes (Merck 1983, p. 935) Ingestion: Yes (Sax 1984, p. 1997) Health Hazards (Acute, Delayed, and Chronic): It is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 Ibs.) person (*Gosselin 1976). It may be assumed that ingestion of 40-60 mg of nicotine is lethal to humans. There is fundamental difference between acute toxicity from use of nicotine as insecticide or from ingestion, and chronic toxicity that may be caused by prolonged exposure to small doses as occurs in smoking (*Encyc Occupat Health and Safety 1983). Maternal smoking during pregnancy is associated with increased risk of spontaneous abortion, low birth weight and still-birth (*The Chemical Society 1975). Nicotine was found as a co-carcinogen in animals (*NRC 1977). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: Low fire hazard when exposed to heat or flame (Sax 1984, p. 1997) LEL: 0.75% (Sax 1984, p. 1997) UEL: 4.0% (Sax 1984, p. 1997) Extinguishing Methods: Extinguish with alcohol foam, dry chemical, or carbon dioxide (Sax 1984, p. 1997). Water may cause frothing if it gets below surface of liquid and turns to steam. However, water fog gently applied to surface will cause frothing which will extinguish the fire (*NFPA 1978). Special Fire Fighting Procedures: Material too dangerous to health to expose firefighters. A few whiffs of the vapor could cause death; vapor or liquid could be fatal on penetrating firefighter's normal full protective clothing. Normal full protective clothing and breathing apparatus available to the average fire department will not provide adequate protection against inhalation or skin contact (*NFPA 1978). ------- CAS Registry Number: 54-11-5 Page 3 of 4 NICOTINE SECTION IV (continued) Unusual Fire and Explosion Hazards: There is a moderate explosion hazard when exposed to heat or flame (.Sax 1984, p. 1997). NFPA Flammability Rating: 1 SECTION V -- REACTIVITY DATA Stability: Unstable: Stable: Yes (normal conditions) (*NFPA 1978) Conditions to Avoid: Heat or flames (*Sax 1975) Incompatibility (Materials to Avoid): Avoid oxidizing materials (Sax 1984, p. 1997). Hazardous Decomposition or Byproducts: When heated to decomposition, it emits nitrogen oxides, carbon monoxide and other highly toxic fumes (Sax 1984, p. 1997). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION It is used as an insecticide, fumigant and in veterinary matters as an ectoparasiticide and anthelmintic (*Merck 1983). Also, used in tanning (*NRC 1977). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) The normal full protective clothing and breathing apparatus available to the average fire department will not provide adequate protection against inhalation or skin contact with this material (*NFPA 1978). Do not touch spilled material; stop leak; reduce vapors with water spray. Small Spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small Dry Spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large Spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- ------- CAS Registry Number: 54-11-5 Page 4 of 4 NICOTINE SECTION VIII (continued) demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 54-11-5 Page 1 of 3 Emergency First Aid Treatment Guide for NICOTINE (54-11-5) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless to pale yellow oily liquid; brown on exposure to air. Odor - Slightly fishy odor when warm. Commercial Forms - 93 to 98% pure liquid; 3 to 5% dust. Uses - Insecticide, fumigant, veterinary medicine, tanning. Other Names - Black Leaf 40, Destruxol Orchid Spray; Futemobac; Nico-dust; Nico-Fume; Ortho N-4 Dust; Ortho N-5 Dust; (S)-3-(l-methyl-2-pyrrolidinyl) pyridine; Tendust. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, phenobarbital, atropine. Signs and Symptoms of Acute Nicotine Exposure: Warning: Seizures may be rapid in onset. Caution is advised. Acute exposure to nicotine may result in headache, dizziness, confusion, agitation, restlessness, lethargy, seizures, and coma. Victims may experience hypertension (high blood pressure), tachycardia (rapid heart rate), and tachypnea (rapid respirations), followed by hypotension (low blood pressure), bradycardia (slow heart rate), and respiratory depression. Cardiac arrhythmias may also occur. ------- EFATG CAS Registry Number: 54-11-5 Page 2 of 3 NICOTINE Gastrointestinal effects include nausea, vomiting, abdominal pain or burning sensation, and diarrhea. Increased salivation, lacrimation (tearing), and sweating may be noted. Emergency Life-Support Procedures: Acute exposure to nicotine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to nicotine. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to nicotine. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. THOROUGHLY wash exposed skin areas with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. ------- EFATG CAS Registry Number: 54-11-5 Page 3 of 3 NICOTINE Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting or attempt to neutralize! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 7. RUSH to a health care facility. ------- CAS Registry Number: 54-62-6 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- AMINOPTERIN CAS Registry Number: 54-62-6 Synonyms: (NIOSH/RTECS 1983, Synonyms, Volume 2, p. 375) Glutamic Acid, N-(p-(((2,4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)-, L-; 4-Amino-4-Deoxypteroylglutamate; 4-Amino-PGA; Aminopteridine; 4-Aminopteroylglutamic Acid; A-Ninopterin; APGA; N-(4-((2,4-Diamino-6- Pteridinyl)Methyl)Amino)Benzoyl)-L-Glutamic Acid; ENT-26079; Folic Acid, 4-Amino-; NSC 739; L-GIutamic Acid, N-[4-[(Diamino-6-Pteridinyl)Methyl] Amino]Benzoyl]- Chemical Formula: C19H2oN8O5 Molecular Weight: 440.47 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD,0 oral (rat) 2.5 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Not Found ------- CAS Registry Number: 54-62-6 Page 2 of 3 AMINOPTERIN SECTION II (continued) Appearance and Odor: Clusters of yellow needles (Hawley 1981, p. 55) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (Hawley 1981, p. 55) Health Hazards (Acute, Delayed, and Chronic): An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion (Hawley 1981, p. 55). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found ------- CAS Registry Number: 54-62-6 Page 3 of 3 AMINOPTERIN SECTION V (continued) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Rodenticide (Merck 1983, pp. 70-71); medicine and rodenticide (Hawley 1981, p. 55). Not registered as a rodenticide in the U.S. (USEPA/Active Ingredients 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Pesticide, Solid, n.o.s.) Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Not Found Emergency and First Aid Procedures: (Non-Specific -- Pesticide, Solid, n.o.s.) Move victim to fresh air; call emergency medical care. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush eyes with running water for at least 15 minutes (DOT 1984, Guide 53). ------- CAS Registry Number: 55-91-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ISOFLUORPHATE CAS Registry Number: 55-91-4 Synonyms: Diisopropyl Fluorophosphate; DFP; Diflupyl; Diflurphate; Diisopropoxyphosphoryl Fluoride; Diisopropyl Fluorophosphonate; Diisopropyl Phosphofluoridate; Diisopropyl Phosphorofluoridate; Diisopropylfluoro- phosphate; Diisopropylfluorophosphoric Acid Ester; Diisopropylphosphoro- fluoridate; Dyflos; Dyphlos; Floropryl; Fluophosphoric Acid, Diisopropyl Ester; Fluorodiisopropyl Phosphate; Fluostigmine; Fluropryl; Isofluro- phosphate; Isopropyl Fluophosphate; Isopropyl Phosphorofluoridate; Neoglaucit; O,O'-Diisopropyl Phosphoryl Fluoride; O,O,-Diisopropyl Fluorophosphate; PF-3; Phosphorofluoridic Acid, Bis(l-Methylethyl) Ester; Phosphorofluoridic Acid, Diisopropyl Ester; T-1703; TL 466; Fluorophosphoric Acid, Diisopropyl Ester; Fluoropryl; Isofluorophate; Isoflurophate Chemical Formula: C6H14FO3P Molecular Weight: 184.15 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.36 mg/liter/10 minutes (*NIOSH/RTECS 1985) TPQ: 100 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 144°F, 62°C at 9 mmHg (*Merck 1983) Specific Gravity (H2O=1): 1.055 (*Merck 1983) Vapor Pressure (mmHg): 0.579 at 20°C (*Merck 1983) Melting Point: -116°F, -82°C (*Merck 1983) Vapor Density (AIR=1): Not Found ------- CAS Registry Number: 55-91-4 Page 2 of 4 ISOFLUORPHATE SECTION II (continued) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1.54% by weight at 25°C (*Merck 1983) Appearance and Odor: Oily liquid ("Hawley 1981). Clear, colorless or faintly yellow liquid (*Osol 1980). SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Merck 1983) Skin: Yes (Sax 1984, p. 1667) Ingestion: Yes (*Gosselin 1984) Health Hazards (Acute, Delayed, and Chronic): This is an organophosphate pesticide (*Morgan 1982). Extremely toxic: probable oral lethal dose in humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for 70 kg person (150 Ib.) (*Gosselin 1984). The material is a cholinesterase inactivator. Even traces of the vapor cause pinpoint pupils (*Merck 1983). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found • ' UEL: Not Found Extinguishing Methods: (Non-Specific -- Organophosphorous Pesticide, n.o.s.) Dry chemical, carbon dioxide, water spray, or foam. For large fires, water spray, fog, or foam. Fight fire from maximum distance. Dike fire control water for later disposal (DOT 1984, Guide 55). Special Fire Fighting Procedures: Stay upwind; keep out of low areas. Wear positive pressure breathing apparatus and special protective clothing (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: May burn but will not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 55-91-4 Page 3 of 4 ISOFLUORPHATE SECTION V ~ REACTIVITY DATA Stability: Unstable: Stable: Yes (*Merck 1983) Conditions to Avoid: Forms hydrofluoric acid in presence of moisture (*Merck 1983). Keep away from sources of heat (*Farm Chemicals Handbook 1984). Anhydrous compounds or oil solutions are stable in glass containers at room temperature (*Merck 1983). Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Forms hydrogen fluoride in presence of moisture; decomposes in water at pH about 2.5 (*Merck 1983). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Research tool in neuroscience for its ability to inhibit cholinesterase (by phosphorylation) on an acute/sub-acute basis and to produce a delayed neuropathy (*Peer Review Committee). An insecticide. Used in Germany as a basis for "nerve gases" (Sax 1984, p. 1667). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) When handling in open containers, protect the eyes, nose, and mouth with a suitable mask, and avoid contact with skin (*Osol 1980). (Non-Specific — Organophosphorus Pesticide, n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material. Use water spray to reduce vapors. Take up small spills with sand or other noncombustible absorbent material and place in containers for later disposal. Dike far ahead of large spills for later disposal (DOT 1984, Guide 55). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 55-91-4 Page 4 of 4 ISOFLUORPHATE SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Respiration depression, muscle weakness, twitching, and convulsions. Sweating, visual disturbances, vomiting, diarrhea, chest and abdominal distress, and sometimes pulmonary edema (*Morgan 1982). Emergency and First Aid Procedures: Do not inhale vapors; avoid contact with skin (*Merck 1983). (Non-Specific — Organophosphorous Pesticide, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal boc temperature. Effects may be delayed; keep victim under observation (DO' 1984, Guide 55). ------- CAS Registry Number: 56-25-7 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- CANTHARIDIN CAS Registry Number: 56-25-7 Synonyms: 7-Oxabicyclo[2.2.1 ]Heptane-2,3-Dicarboxylic Anhydride, 2,3-Dimethyl-; l,2-Dimethyl-3,6-Epoxyperhydrophthalic Anhydride; 4,7-Epoxyisobenzofuran-l,3-Dione, Hexahydro-3a,7a-Dimethyl-, (3a alpha, 4 beta, 7 beta, 7a alpha)-; 2,3-Dimethyl-7-Oxabicyclo[2.2.1]Heptane-2,3- Dicarboxylic Anhydride; CAN; Cantharides Camphor; Cantharidine; Cantharone; Exo-l,2-cis-Dimethyl-3,6-Epoxyhexahydrophthalic Anhydride; Hexahydro-3a alpha, 7a alpha-Dimethyl-4 beta, 7 beta-Epoxyisobenzofuran-l,3-dione; Kantaridin Chemical Formula: C10H12O4 Molecular Weight: 196.21 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDlo oral (hu- man) 0.428 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Sublimes at 230°F, 110°C (Merck 1983, p. 242) Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 424°F, 218°C (*Weast 1979) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble in cold water (*Merck 1976); somewhat ------- CAS Registry Number: 56-25-7 Page 2 of 3 CANTHARIDIN SECTION II (continued) soluble in hot water (*Merck 1976). Appearance and Odor: Brown to black powder (Sax 1984, p. 627); orthorhombic plates, scales (Merck 1983, p. 242). SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Sax 1979) Skin: Yes (*Rumack 1975 to Present) Ingestion: Yes (*Arena 1979) Health Hazards (Acute, Delayed, and Chronic): It is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste of less than 7 drops for a 70 kg (150 Ib.) person (*Gosselin 1976). It is very toxic by absorption through skin (*Merck 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found ------- CAS Registry Number: 56-25-7 Page 3 of 3 CANTHARIDIN SECTION V (continued) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition it emits acrid smoke and irritating fumes (*Sax 1979). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Formerly used as a counter-irritant and vesicant (*IARC 1972-1985). Also used for the removal of benign epithelial growth, e.g., warts (*Gilman 1980). Used as an experimental antitumor agent. Active ingredient in Spanish fly, a reputed aphrodisiac (*Peer Review Committee). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation and skin contact (see Section III above). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms from ingestion include vomiting, abdominal pain, shock, bloody diarrhea, pain in throat and stomach, swelling and blistering of tongue, difficulty swallowing, salivation, slow and painful urination, and thirst. There may be delirium, fainting, and tetanic convulsions (*Goodman 1975, *Rumack 1975 to Present, *Arena 1979, *Gosselin 1976). Eye contact results in irritation with much swelling of the lids (*Grant 1974). Initial tissue reaction upon contact with the skin is swelling followed by blister formation within 24 hours (*Doull 1980). Emergency and First Aid Procedures: For ingestion, induce vomiting with syrup of ipecac. For skin contact thoroughly wash contaminated area with soap and water. Eyes should be irrigated with plain tap water (*Rumack 1975 to Present). ------- CAS Registry Number: 56-38-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PARATHION CAS Registry Number: 56-38-2 Synonyms: Phosphorothioic Acid, O,O-DiethyI O-(p-Nitrophenyl) Ester (Liquid Mixture); Parathion liquid; Alkron; Aileron; American Cyanamid 3422; Aphamite; Bayer E-605; Bladan; Diethyl 4-Nitrophenyl Phosphorothionate; Diethyl p-Nitrophenyl Thionophosphate; Diethyl Parathion; Diethyl-p-Nitrophenyl Monothiophosphate; DNTP; E 605; ENT 15,108; Ethyl Parathion; Etilon; Folidol; Fosferno; Fostox; Genithion; NA 2783 (DOT); NCI-C00226; Niran; Nitrostigmine; O,O-Diethyl O-(p-Nitrophenyl) Phosphorothioate; O,O-Diethyl O-(p-nitrophenyl) Thionophosphate; O,O-Diethyl O-4-Nitrophenyl Thiophosphate; O,O-Diethyl O-p- Nitrophenyl Phosphorothioate; Oleoparathion; Panthion; Paraflow; Paramar; Paraphos; Parawet; Phenphos; Phoskil; Phosphenol; Phosphorothioic Acid O,O-Diethyl O-(4-Nitrophenyl) Ester; Rhodiatox; SNP; Stathion; Sulphos; Thiophos; Vapophos Chemical Formula: C10H14NO5PS Molecular Weight: 291.27 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.084 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 100 (pounds) RQ: 1 (pounds) (statutory); 10 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 707°F, 375°C (*Merck 1983) Specific Gravity (H2O=1): 1.26 (*Merck 1983) Vapor Pressure (mmHg): 0.0000378 at 20°C (*Worthing 1979) Melting Point: 43°F, 6°C (*Merck 1983) Vapor Density (AIR=1): Not Found ------- CAS Registry Number: 56-38-2 Page 2 of 4 PARATHION SECTION II (continued) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Practically insoluble; 12.4 mg/liter at 20°C (*Bowman 1979) Appearance and Odor: Pale yellow liquid; technical grade is brown and has a garlic-like odor (*Worthing 1979). SECTION III -- HEALTH HAZARD DATA OSHA PEL: TWA 0.1 mg/m3 (NIOSH 1978, p. 148) ACGIH TLV: TWA 0.1 mg/ms (skin) (ACGIH 1986-87, p.26) IDLH: 20 mg/m3 (*Encyc of Occupat Health and Safety 1983) Other Limits Recommended: NIOSH: 0.05 mg/m3, 10 hour TWA (NIOSH 1987, p. 184) Routes of Entry: Inhalation: Yes (*Gosselin 1976) Skin: Yes (*Gosselin 1976) Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): This material is extremely toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person. As little as 1 drop can endanger life if splashed in the eye. Toxicity is highest by inhalation (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: People at special risk are those with a history of glaucoma, cardiovascular disease, hepatic disease, renal disease, or central nervous system abnormalities (*Encyc Occupat Health and Safety 1983). SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 248-320°F, 120-160°C (Method not given) (*Clayton and Clayton 1981-82) Flammable Limits: Not highly flammable (*Encyc Occupat Health and Safety 1971) LEL: Not Found UEL: Not Found Extinguishing Methods: Use water spray, dry chemical, foam, or carbon dioxide (*NFPA 1978). Special Fire Fighting Procedures: Use water spray to keep fire-exposed ------- CAS Registry Number: 56-38-2 Page 3 of 4 PARATHION SECTION IV (continued) containers cool. If a leak or spill has not ignited, use water spray to disperse vapors and to provide protection for firefighters. Water spray may be used to flush spills away from exposures. Fight advanced or massive fires from a safe distance or from a protected location. Special protective clothing should be worn; normal protective clothing may be penetrated (*NFPA 1978). Unusual Fire and Explosion Hazards: When heated to decomposition, it can emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur. High pressure hoses may scatter material from broken containers (*NFPA 1978). Containers may explode when heated (*CHRIS 1978). NFPA Flammability Rating: 1 SECTION V -- REACTIVITY DATA Stability: Unstable: Stable: Yes, in distilled water and in acid solution (*Hawley 1981) Conditions to Avoid: Store below 25-30°C (*Farm Chemicals Handbook 1983). It slowly decomposes in air and hydrolyzes in the presence of alkaline material (*Hawley 1981). Containers may explode when heated (*CHRIS 1978). Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, the material can emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur (*NFPA 1978). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI « USE INFORMATION This material is used as an insecticide (*SRI) and is used almost exclusively in agriculture (Hayes 1982, p. 379). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) In case of leaks or spills, special protective clothing should be worn. Use water spray to disperse vapors and flush spills away (*NFPA 1978). Ventilate area of spill or leak. Spills may be absorbed in vermiculite, dry sand, earth, or a similar material (*NIOSH/OSHA 1981). ------- CAS Registry Number: 56-38-2 Page 4 of 4 PARATHION SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 56-38-2 Page 1 of 3 Emergency First Aid Treatment Guide for PARATHION (56-38-2) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Pale yellow or brown liquid. Odor - Garliclike (commercial form). Commercial Form - Deep brown liquid in tins and steel drums. Use - Pesticide. Materials to Avoid - Alkali, strong oxidizers. Other Names - Alkron; Aileron; DNTP; ethyl parathion; Etilon; Folidol; Fosferno; Fostex; Genithion; Niran; Nitrostigmine; Oleoparathion; Paraflow; Paramar; Paraphos; Parawet; Phoskil; Phosphenol; phosphorothioic acid, O,O- diethyl O-(p-nitrophenyl) ester; Rhodiatox; Stathion; Thiophos; Vapophos. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Parathion Exposure: Caution: Parathion is a cholinestorase inhibitor. It has been reported that as little as one drop of parathion can endanger life if splashed in the eye. Toxicity is highest by inhalation. Acute exposure to parathion may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. ------- EFATG CAS Registry Number: 56-38-2 Page 2 of 3 PARATHION The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur. Emergency Life-Support Procedures: Acute exposure to parathion may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to parathion. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to parathion. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. ------- EFATG CAS Registry Number: 56-38-2 Page 3 of 3 PARATHION 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of parathion is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of parathion may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 56-72-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- COUMAPHOS CAS Registry Number: 56-72-4 Synonyms: 3-Chloro-4-Methyl-7-Coumarinyl Diethyl Phosphorothioate; 3-Chloro-4-Methyl-7-Hydroxycoumarin Diethyl Thiophosphoric Acid Ester; 3-Chloro-4-Methylumbelliferone O-Ester with O,O-Diethyl Phosphorothioate; 3-Chloro-7-Hydroxy-4-Methyl-Coumarin O,O-Diethyl Phosphorothioate; 3-Chloro- 7-Hydroxy-4-Methyl-Coumarin O-Ester with O,O-Diethyl Phosphorothioate; Agridip; Asunthol; Asuntol; Azunthol; Bay 21/199; Bayer 21/199; Baymix; Baymix 50; Co-Ral; Coumafos; Coumarin, 3-Chloro-7-Hydroxy-4-Methyl-, O-Ester with O,O-Diethyl Phosphorothioate; Diethyl 3-Chloro-4-Methylumbelliferyl Thionophosphate; Diethyl Thiophosphoric Acid Ester of 3-Chloro-4-Methyl- 7-Hydroxycoumarin; Diolice; ENT 17,957; Meldane, Meldone, Muscatox, NCI-C08662; O,O-Diethyl 3-Chloro-4-Methyl-7-Umbelliferone Thiophosphate; O,O-Diethyl O-(3-Chloro-4-Methyl-2-Oxo-2H-Benzopyran-7-yl) Phosphorothioate; O,O-Diethyl O-(3-Chloro-4-Methyl-7-Coumarinyl) Phosphorothioate; O,O-Diethyl O-(3-Chloro-4-Methylcoumarinyl-7) Thiophosphate; O,O-Diethyl O-(3-Chloro-4-Methylumbelliferone) Thiophosphate; O,O-Diethyl O-(3-Chloro-4- Methylumbelliferyl) Phosphorothioate; O-3-Chloro-4-Methyl-7-Coumarinyl O,O-Diethyl Phosphorothioate; Phosphorothioic Acid, O,O-Diethyl Ester, O-Ester with 3-Chloro-7-Hydroxy-4-Methylcoumarin; Phosphorothioic Acid, O-(3-Chloro- 4-Methyl-2-Oxo-2H-l-Benzopyran-7-yl) O,O-Diethyl Ester; Resistox; Resitox; Suntol; Umbethion Chemical Formula: C14H16C1O5PS Molecular Weight: 362.78 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.303 mg/liter (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found ------- CAS Registry Number: 56-72-4 Page 2 of 4 COUMAPHOS SECTION II (continued) Specific Gravity (H2O=1): 1.31 at 25°C (*Spencer 1973) Vapor Pressure (mmHg): 0.0000001 at 20°C (*Spencer 1973) Melting Point: 196°F; 91°C (*Merck 1983) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (*Merck 1983) Appearance and Odor: Slightly brownish crystals (*Merck 1983). Slight odor of sulfur compound (*CHRIS 1978) SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*DOT 1984) Skin: Yes (*DOT 1984) Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): Very toxic, probable oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 Ib.) person (*Gosselin 1976). May be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes (*DOT 1984). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE .AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: This material may burn but does not ignite easily (*DOT 1984). Extinguish with water, foam, carbon dioxide, or dry chemicals (*CHRIS 1978) Special Fire Fighting Procedures: Use organic vapor respirator, rubber gloves, and goggles (*CHRIS 1978). Dike fire control water for disposal later (*DOT 1984). ------- CAS Registry Number: 56-72-4 Page 3 of 4 COUMAPHOS SECTION IV (continued) Unusual Fire and Explosion Hazards: Toxic and irritating oxides of sulfur and phosphorus may form in fire (*CHRIS 1978). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Stable: Stable in water (*Merck 1983) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Incompatible with piperonyl butoxide (*Farm Chemicals Handbook 1983) Hazardous Decomposition or Byproducts: When heated to decomposition, it emits very toxic fumes of sulfur oxides, phosphorus oxides, and chlorides (Sax 1984, p. 726) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION For control of a wide variety of livestock insects including cattle grubs, lice, scabies, flies, and ticks; the common ectoparasites of sheep, goats, horse, swine, and poultry as well as for screwworms in all these animals (Farm Chemicals Handbook 1983, p. C61). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel, place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 56-72-4 Page 4 of 4 COUMAPHOS * SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 56-72-4 Page 1 of 3 Emergency First Aid Treatment Guide for COUMAPHOS (56-72-4) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - White crystals. Odor - Slightly sulfurous. Commercial Forms - 1 and 5% pure dusts, 3% pure spray foam, 5 to 50% pure slightly brownish crystals, 25% pure wettable powder. Use - Veterinary insecticide. Other Names - Agridip; Asuntol; 3-chloro-4-methyl-7-coumarinyl diethyl phosphorothioate; Co-Ral; Coumafos; Meldane; Muscatox; Negasunt; Resistox; Suntol; Umbethion. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Coumaphos Exposure: Note: Coumaphos is a cholinesterase inhibitor. Acute exposure to coumaphos may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) and chest pain may be noted. Hypertension (high blood pressure) is not uncommon. Respiratory effects include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur. ------- EFATG CAS Registry Number: 56-72-4 Page 2 of 3 COUMAPHOS Emergency Life-Support Procedures: Acute exposure to coumaphos may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to coumaphos. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to coumaphos. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least IS minutes. 5. Wash exposed skin areas three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 56-72-4 Page 3 of 3 COUMAPHOS Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of coumaphos is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of coumaphos may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainly exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 57-14-7 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY ~ DIMETHYLHYDRAZINE CAS Registry Number: 57-14-7 Synonyms: As-Dimethylhydrazine; Asym Dimethylhydrazine; Asymmetric Dimethylhydrazine; Dimazin; Dimazine; 1,1-Dimethylhydrazine; Dimethylhydrazine Unsymmetrical; DMH; Hydrazine, 1,1-Dimethyl; N,N-Dimethylhydrazine; U-Dimethylhydrazine; UDMH; Uns-Dimethylhydrazine; Unsym-Dimethylhydrazine; Unsymmetrical-Dimethylhydrazine Chemical Formula: C2H8N2 Molecular Weight: 60.10 SECTION I ~ REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC60 inhalation (mus) 0.422 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory); 10 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 147°F, 63.9°C at 760 mmHg (*Merck 1983) Specific Gravity (H2O=1): 0.7914 at 220C/4°C (*IARC 1972-1985) Vapor Pressure (mmHg): 157 mmHg at 25°C (Sax, 1986, p.65) Melting Point: -72°F, -58°C (*Merck 1983) Vapor Density (AIR=1): 1.94 (*Sax 1979) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Very soluble (*Encyc Occupat Health and Safety 1983) Appearance and Odor: Clear, colorless liquid with characteristic ammonia-like fish odor (*IARC 1972-1985). ;: ------- CAS Registry Number: 57-14-7 Page 2 of 4 DIMETHYLHYDRAZINE SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 1 mg/m8, (0.5 ppm) (NIOSH 1987, p.108) ACGIH TLV: TWA 1 mg/ms, (0.5 ppm) (skin) (ACGIH 1986-87, p.17) IDLH: 50 ppm (NIOSH/OSHA 1978, p. 88) Other Limits Recommended: NIOSH: 0.15 mg/ms, 120 minute ceiling (NIOSH 1987, p.108). Industrial substance suspect of carcinogenic potential for humans (ACGIH 1983, p. 43). SPEGL 0.24 ppm (60 minutes) (NRC 1985b, pp. 37-48). Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Yes (*Sax 1975) Ingestion: Yes (*Sax 1975) .Health Hazards (Acute, Delayed, and Chronic): This compound exhibits high acute toxicity as a result of exposure by all routes. Death or permanent injury may result after very short exposure to small quantities (*Sax 1975). Chronic exposure may cause pneumonia, liver damage, and kidney damage (*Rumack 1975 to Present). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 5°F, -15°C (CC) (*NFPA 1978) Flammable Limits: LEL: 2% (*Sax 1979) UEL: 95% (*Sax 1979) Extinguishing Methods: Use dry chemical, carbon dioxide, water spray, or foam for small fires (*DOT 1984). In large fires water fog, carbon dioxide, and bicarbonate agents may allow flashback and explosive re-ignition (*CHRIS 1978). Special Fire Fighting Procedures: Move containers from fire area if it can be done without risk. Dike fire control water for later disposal, do not scatter the material. Cool containers that are exposed to flames with water until well after fire is out, wear positive pressure breathing apparatus and special protective clothing. Isolate for one-half mile in all directions if tank car or truck is involved in fire (*DOT 1984). Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an enclosed area (*CHRIS 1978). Vapors may travel to a source of ignition and flashback. Runoff to sewer may create fire or explosion hazard (*DOT 1984). NFPA Flammability Rating: 3 ------- CAS Registry Number: 57-14-7 Page 3 of 4 DIMETHYLHYDRAZINE SECTION V ~ REACTIVITY DATA Stability: Unstable: Stable: Yes (NFPA .1984, p. 325M-43) Conditions to Avoid: Dangerous when exposed to heat, flame, or oxidizers (*Sax 1979). Incompatibility (Materials to Avoid): Dissolves, swells, and disintegrates many plastics (*CHRIS 1978). Hazardous Decomposition or Byproducts: When it decomposes, 1,1-dimethylhydrazine gives off toxic nitrogen compound fumes (*Rumack 1975 to Present). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 364) Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Major uses include: chemical synthesis; stabilizer for organic peroxide fuel additives; absorbent for acid gases; photography (*Hawley 1977); base in rocket fuel formulations (*Merck 1983); stabilizer for plant growth regulator (*Clayton and Clayton 1981-82). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Shut off ignition sources. Do not touch spilled material. Stop leak if this can be done without risk. Use water spray to reduce vapors. Take up small spills with sand or other non-combustible absorbent material and place into containers for later disposal. Dike far ahead of large spills for later disposal (*DOT 1984). Spills also may be removed with an aspirator. Transfer to glass container and neutralize with dilute sulfuric acid. Drain with copious amounts of water (*Rumack 1975 to Present). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 57-14-7 Page 4 of 4 DIMETHYLHYDRAZINE SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl EXCELLENT/MANY Butyl/Neoprene POOR/LIMITED* CPE POOR/LIMITED Chlorobutyl GOOD/LIMITED Neoprene POOR/MANY Nitrile POOR/MANY PVC POOR/MANY Teflon POOR/LIMITED Viton POOR/LIMITED Viton/Neoprene POOR/LIMITED* *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 57-14-7 Page 1 of 3 Emergency First Aid Treatment Guide for DIMETHYLHYDRAZINE (57-14-7) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Clear, colorless liquid. Odor - Ammonialike. Commercial Form - 98% pure liquid in drums or tank cars. Uses - Chemical synthesis, stabilizer for organic peroxide rocket fuel formulations, acid gas absorbent, plant growth regulator, photography. Materials to Avoid - Oxidizers. Caution: Highly flammable. Avoid sources of extreme heat or ignition including sparks or fire. Dimethylhydrazine will emit toxic nitrogen compounds when heated to decomposition. Other Names - Asym dimethylhydrazine, Dimazin, 1,1-dimethylhydrazine, UDMH. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, phenobarbital, pyridoxine. ------- EFATG CAS Registry Number: 57-14-7 Page 2 of 3 DIMETHYLHYDRAZINE Signs and Symptoms of Acute Dimethylhydrazine Exposure: Warning: Effects may be delayed for hours to days. Caution is advised. Signs and symptoms of acute exposure to dimethylhydrazine may include eye irritation, facial numbness, facial swelling, and increased salivation. Headache, twitching, seizures, convulsions, and coma may also occur. Gastrointestinal effects include anorexia, nausea, and vomiting. Pulmonary edema and hypotension (low blood pressure) are common. Dimethylhydrazine is toxic to the liver, ruptures red blood cells, and may cause kidney damage. Dermal contact may result in strong skin and mucous membrane irritation. Emergency Life-Support Procedures: Acute exposure to dimethylhydrazine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as dimethylhydrazine-resistant sheeting and disposable bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to dimethylhydrazine. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to dimethylhydrazine. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. ------- EFATG CAS Registry Number: 57-14-7 Page 3 of 3 DIMETHYLHYDRAZINE 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of dimethylhydrazine is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of dimethylhydrazine may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 57-24-9 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - STRYCHNINE CAS Registry Number: 57-24-9 Synonyms: Certox; Dolco Mouse Cereal; Kwik-Kil; Mole Death; Mouse-Nots; Mouse-Rid; Mouse-Tox; Pied Piper Mouse Seed; Ro-Dex; Sanaseed; Strychnos; Strychnidin-10-one; Strychnin Chemical Formula: C21H22N2O2 Molecular Weight: 334.40 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD60 oral (mus) 2 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: 518°F, 270°C at SmmHg (*Merck 1983) Specific Gravity (H2O=1): 1.36 at 20°C/4°C (*Merck 1983) Vapor Pressure (mmHg): Not Found Melting Point: 514-554°F, 268-290°C (*Merck 1983) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1 g in 6400 ml (*Merck 1983). Appearance and Odor: Colorless, transparent crystals or white crystalline powder; odorless (*Osol 1980). ------- CAS Registry Number: 57-24-9 Page 2 of 3 STRYCHNINE * SECTION III - HEALTH HAZARD DATA OSHA PEL: 0.15 mg/ms (NIOSH 1987, p. 210) ACGIH TLV: TWA 0.15 mg/ms (ACGIH 1986-87, p. 29) IDLH: 3 mg/ms (NIOSH/OSHA 1978, p. 168) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*DOT 1984) Skin: Not Found Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): Super toxic; probable oral lethal dose in humans is less than 5 mg/kg, a taste (less than 7 drops) for a 70 kg (150 Ib.) person. It causes violent generalized convulsions. Death results from respiratory arrest as the respiratory muscles are in sustained spasm (*Gosselin 1976). The lowest lethal oral dose reported for humans is 30 mg/kg (*NIOSH/RTECS 1985). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: Material may burn but does not ignite readily (*DOT 1984). LEL: Not Found UEL: Not Found Extinguishing Methods: Extinguish fire using agent suitable for type of surrounding fire; material itself does not burn or burns with difficulty. Use water in flooding quantities as fog. Use alcohol foam, carbon dioxide, or dry chemical (Student 1981, p. 482). Special Fire Fighting Procedures: Not Found > Unusual Fire and Explosion Hazards: When heated, emits highly toxic fumes (*Sax 1979). Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution (*DOT 1984). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Osol 1980) Conditions to Avoid: Protect from light (*Merck 1983) ------- CAS Registry Number: 57-24-9 Page 3 of 3 STRYCHNINE SECTION V (continued) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Material (and its salts) is used for destroying rodents and predatory animals and for trapping fur-bearing animals (*Merck 1983). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material; stop leak if you can do so without risk. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53). Avoid breathing dusts, and fumes from burning materials. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water (Student 1981, p. 482). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 57-24-9 Page 1 of 3 Emergency First Aid Treatment Guide for STRYCHNINE (57-24-9) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance. Characteristics: Pure Forms - Colorless, transparent crystals or white crystalline powder. Odor - None; bitter taste. Commercial Form - Poisoned baits, usually as colored grain. Uses - Rodenticide, sedatives, veterinary products. Other Names - Certox, Kwik-Kil, Mouse-Rid, Mouse-Tox, Ro-Dex, Sanaseed, Strychinos, strychnidin-10-one. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, phenobarbital, sodium bicarbonate, pancuronium bromide or curare, succinylcholine. Signs and Symptoms of Acute Strychnine Exposure: Warning: Strychnine may induce convulsions within 15 to 60 minutes following exposure. Caution is advised. Respiratory paralysis and arrest are likely to occur following severe exposure to strychnine. Signs and symptoms of acute exposure generally involve excitation of all portions of the central nervous system. Convulsions, bilateral horizontal nystagmus (rapid, synchronous, horizontal oscillations of the eyeballs), agitation, restlessness, apprehension, and abrupt, jerking movements of the extremities may occur. ------- EFATG CAS Registry Number: 57-24-9 Page 2 of 3 STRYCHNINE Victims may also experience stiffness, painful muscle cramping (especially in the legs), and opisthotonos (spasm in which the spine and extremities are bent with convexity forward, the body resting on the head and heels). Vomiting and renal failure, as well as cyanosis (blue tint to skin and mucous membranes) and rhabdomyolysis (destruction of skeletal muscle), may be found. Emergency Life-Support Procedures: Acute exposure to strychnine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to strychnine. Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions. 2. RUSH to a health care facility! 3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to strychnine. Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions. 2. RUSH to a health care facility!. ------- EFATG CAS Registry Number: 57-24-9 Page 3 of 3 STRYCHNINE 3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 4. Remove contaminated clothing as soon as possible. 5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least IS minutes. 6. Wash exposed skin areas THOROUGHLY with soap and water. 7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions. 2. RUSH to a health care facility! 3. DO NOT induce vomiting or attempt to neutralize. 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 6. Promote excretion by administereing a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. ------- CAS Registry Number: 57-47-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PHYSOSTIGMINE CAS Registry Number: 57-47-6 Synonyms: Calabarine; Carbamic Acid, Methyl-, Ester with Eseroline; Erserine; Eserine; Eserolein, Methylcarbamate (Ester); Esromiotin; Ezerin; Physostol; Pyrrolo(2,3-b)indol-5-ol, l,2,3,3a,8,8a-Hexahydro-l,3a,8-Trimethyl-, Methylcarbamate (Ester), (3aS-cis)- Chemical Formula: C15H21NSO2 Molecular Weight: 275.34 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mus) 4.5 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 221-223°F, 105-106°C (*Merck 1976) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Slightly soluble (*Merck 1976) Appearance and Odor: White, odorless, microcrystalline powder (*Osol 1980) ------- CAS Registry Number: 57-47-6 Page 2 of 4 PHYSOSTIGMINE SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Gilman 1980) Skin: Yes (*Gilman 1980) Ingestion: Yes (*Gilman 1980) Health Hazards (Acute, Delayed, and Chronic): Super toxic. Probable oral lethal dose is less than 5 mg/kg for a 70 kg (150 Ib.) person (*Gosselin 1984). Material is a cholinesterase inhibitor. Effects of exposure may involve the respiratory, gastrointestinal, cardiovascular and central nervous systems. Death occurs due to respiratory paralysis or impaired cardiac function. Time to death may vary from 5 minutes to 24 hours, in severely poisoned patients, depending on factors such as the dose and route (*Goodman 1980). Medical Conditions Generally Aggravated by Exposure: Persons with asthma and/or persons that require drugs containing choline esters are at risk (*Osol 1975). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: This is a carbamate pesticide (Hayes 1982, p. 436). As for carbamate pesticides, extinguish fire using agent suitable for type of surrounding fire (material itself burns with difficulty). Use water in flooding quantities as fog. Use alcohol foam, carbon dioxide or dry chemical (Student 1981, p. 104). Special Fire Fighting Procedures: This is a carbamate pesticide (Hayes 1982, p. 436). As for carbamate pesticides, wear self-contained breathing apparatus when fighting fires (Student 1981, p. 104). Unusual Fire and Explosion Hazards: It is a slight fire hazard (Sax 1984, p. 2228). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found ------- CAS Registry Number: 57-47-6 Page 3 of 4 PHYSOSTIGMINE SECTION V (continued) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Keep from light and heat (*Merck 1976). Hazardous Decomposition or Byproducts: When heated to decomposition it emits toxic fumes of nitrogen oxides (Sax 1984, p. 2228). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Physostigmine is a carbamate pesticide (Hayes 1982, p. 436). Material is used as a cholinergic (anticholinesterase) agent and as a veterinary medication (*Merck 1976). Listed as a carbamate pesticide in Sections III and VII, however, physostigmine is not registered in the U.S. as such (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) This is a carbamate pesticide (Hayes 1982, p. 436). As for other carbamate pesticides, avoid breathing dusts, and fumes from burning materials. Keep upwind. Avoid bodily contact with the material. Wash away any material which may have contacted the body with copious amounts of water or soap and water (*Student 1981). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: General symptoms include: increased secretions, fatigability and generalized weakness, involuntary twitching, severe weakness of skeletal muscles. Symptoms of exposure to material by major organ system: gastrointestinal: lack of appetite, nausea and vomiting, abdominal cramps and diarrhea. Central nervous system: confusion, uncoordination, slurred speech, loss of reflexes, rapid, irregular breathing, generalized convulsions, and coma. Cardiovascular: slowed heart beat resulting in hypotension and fall in cardiac output (*Goodman 1980). .- ------- CAS Registry Number: 57-47-6 Page 4 of 4 PHYSOSTIGMINE SECTION IX (continued) Emergency and First Aid Procedures: Administer artificial respiration and oxygen if needed (Sax 1984, p. 2228). If the victim's skin and hair are contaminated, bathe with soap and water. If the material was ingested, the stomach must be emptied (*Morgan 1976). ------- CAS Registry Number: 57-57-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - PROPIOLACTONE, beta- CAS Registry Number: 57-57-8 Synonyms: beta-Propiolactone; 2-Oxetanone; 3-Hydroxypropionic Acid Lactone; 3-Hydroxypropionic Acid, beta-Lactone; 3-Propanolide; 3-Propiolactone; beta-Propionolactone; beta-Proprolactone; Betaprone; BPL; Hydracrylic Acid Beta-Lactone; Hydracrylic Acid, beta Lactone; Propanoic Acid, 3-Hydroxy-,beta-Lactone; Propanolide; Propiolactone; Propionic Acid 3-Hydroxy-beta-Lactone; Propionic Acid, 3-Hydroxy-, beta-Lactone Chemical Formula: CSH4O2 Molecular Weight: 72.06 SECTION I ~ REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.074 mg/liter (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 324°F, 162°C, decomposes (*Merck 1976) Specific Gravity (H2O=1): 1.146 at 20°C/4°C (*Merck 1976) Vapor Pressure (mmHg): 3.4 at 25°C (*IARC 1972-1985) Melting Point: -27°F, -33°C (*Merck 1976) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 37% by volume (*Merck 1976) ------- CAS Registry Number: 57-57-8 Page 2 of 4 PROPIOLACTONE, beta- SECTION II (continued) Appearance and Odor: A colorless liquid with a slightly sweetish, pungent odor (*Encyc Occupat Health and Safety 1971; *IARC 1972-1985) SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: TWA 1.5 mg/ms, (0.5 ppm); STEL 3 mg/ms,(l ppm) (ACGIH, 19i 30) IDLH: Not Found Other Limits Recommended: Industrial substance suspect of carcinogenic potential for humans (ACGIH 1984, p. 41). Routes of Entry: Inhalation: Yes (*Sax 1968) Skin: Yes (Weiss 1980, p. 776) Ingestion: Yes (*Sax 1968) Health Hazards (Acute, Delayed, and Chronic): The toxicity potential of this material via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities (*Sax 1968). It is a carcinogen (Weiss 1980, p. 776). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 70°C (158°F) (no method given) (*Merck 1976) Flammable Limits: LEL: 2.9% (*NFPA 1979) UEL: Not Found Extinguishing Methods: Alcohol foam (*Sax 1979). Extinguish with water, dry chemical, foam, or carbon dioxide (Weiss 1980, p. 776). Special Fire Fighting Procedures: Wear air mask, goggles or face shield, rubber gloves, and protective clothing to prevent all skin contact. Cool exposed containers with water (Weiss 1980, p. 776). Unusual Fire and Explosion Hazards: Containers may explode (Weiss 1980, p. 776). When heated to decomposition, it emits acrid smoke and fumes (Sax 1984, p. 2102). NFPA Flammability Rating: 2 SECTION V - REACTIVITY DATA Stability: Unftable: Stable: Yes, stable when stored at 5°C (*Merck 1983) ------- CAS Registry Number: 57-57-8 Page 3 of 4 PROPIOLACTONE, beta- SECTION V (continued) Conditions to Avoid: Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard (*Sax 1968). Tends to polymerize on storage (*IARC 1972-1985). Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits acrid smoke and fumes (Sax 1984, p. 2102). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Avoid elevated temperatures (Weiss 1980, p. 776). SECTION VI -- USE INFORMATION Intermediate in organic synthesis; disinfectant (*Merck 1976); sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments (*SRI). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid contact with liquid. Keep people away. Stop discharge (Weiss 1980, p. 776). Avoid inhalation (see Section III above). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED Neoprene POOR/LIMITED Nitrile POOR/LIMITED PE POOR/MANY PVC POOR/LIMITED Viton POOR/LIMITED *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 57-57-8 Page 4 of 4 PROPIOLACTONE, beta- SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Inhalation causes irritation of nose, throat, and respiratory tract. Contact of liquid with eyes causes irritation and tears. Contact with skin causes irritation and blistering; fluid from blisters may cause additional blistering of adjacent skin. Ingestion causes burns of mouth and stomach (Weiss 1980, p. 776). Emergency and First Aid Procedures: Get medical attention following all exposures to this compound. In case of inhalation, move victim to fresh air; if breathing has stopped, give artificial respiration. If there has been eye contact, flush eyes with water for at least 15 minutes. In case of skin contact, flush with water (Weiss 1980, p. 776). ------- CAS Registry Number: 57-64-7 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PHYSOSTIGMINE, SALICYLATE (1:1) CAS Registry Number: 57-64-7 Synonyms: (SANSS 1983 Synonyms): Eserine Salicylate; Physostol Salicylate; Salicylic Acid, compound with Physostigmine; Benzoic Acid, 2-Hydroxy-, compound with (3aS-cis)-l,2,3,3a,8,8a-Hexahydro-l,3a,8- Trimethylpyrrolo[2,3-b]indol-5-yl Methylcarbamate (1:1) Chemical Formula: C15H21NSO2-C7H6O3 Molecular Weight: 413.52 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mouse) 2.5 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 365-369°F, 185-187°C (Merck 1983, p. 1065) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1 gram/75 mL at 25°C (Merck 1983, p. 1065) Appearance and Odor: Crystal form that turns red on exposure to heat or light (Merck 1983, p. 1065). ; ------- CAS Registry Number: 57-64-7 Page 2 of 3 PHYSOSTIGMINE, SALICYLATE (1:1) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (Sax 1984, p. 2228) Health Hazards (Acute, Delayed, and Chronic): This compound is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 Ib. person. It is a cholinesterase inhibitor (Gosselin 1984, p. 11-245). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits toxic fumes of nitrogen oxides (Sax 1984, p. 2228). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found ------- CAS Registry Number: 57-64-7 Page 3 of 3 PHYSOSTIGMINE, SALICYLATE (1:1) SECTION VI -- USE INFORMATION Not Found SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Not Found SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: This compound is similar to physostigmine (Gosselin 1984, p. H-245). Symptoms include nausea, vomiting, abdominal cramps, diarrhea, excessive salivation, sweating, lassitude, weakness, tightness in chest, vision disorders, tearing, ciliary muscle spasm, loss of muscle coordination, slurring of speech, twitching of muscle, difficulty in breathing, bluing of skin, convulsions, coma and death (Gosselin 1984, p. 111-89). Emergency and First Aid Procedures: This compound is similar to physostigmine (Gosselin 1984, p. 11-245). Give oxygen and artificial respiration as needed. Wash contaminated areas of the skin with soap and water. Irrigate the eyes with water or saline. Keep patient under constant observation for at least 24 hours (Gosselin 1984, p. 111-89). COMMENTS Sources with no information: Doull 1980 Clayton and Clayton 1981-82 NFPA 1984 ------- CAS Registry Number: 57-74-9 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- CHLORDANE CAS Registry Number: 57-74-9 Synonyms: l,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-Hexahydro-4,7- Methanoindene; l,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-Hexahydro-4,7-Methylene Indane; 4,7-Methano-lH-Indene, l,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a- Hexahydro-; 4,7-Methanoindan, 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-Tetrahydro-; 1068; Aspon-Chlordane; CD 68; Chlor Kil; Chlordane, Liquid (DOT); Chlorindan; Corodan; Dowchlor; ENT 9,932; ENT-9932; HCS 3260; Kypchlor; M 140; M 410; NCI-C00099; Niran; Octa-Klor; Octachloro-4,7-Methanohydroindane; Octachloro- 4,7-Methanotetrahydroindane; Octachlorodihydrodicyclopentadiene; Oktaterr; Ortho-Klor; Synklor; TAT Chlor 4; Topiclor; Toxichlor; Velsicol 1068; Belt Chemical Formula: C10H6C18 Molecular Weight: 409.80 SECTION I « REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC60 inhalation (cat) 0.1 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory); 1 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II » PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 347°F, 175°C at 2 mmHg ('Sunshine 1969) Specific Gravity (H2O=1): 1.56-1.57 at 25°C/0°C (*Merck 1983) Vapor Pressure (mmHg): 0.00001 at 25°C (*Sunshine 1969) Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found ------- CAS Registry Number: 57-74-9 Page 2 of 4 CHLORDANE SECTION II (continued) Solubility in Water: Insoluble (*Merck 1983) Appearance and Odor: Amber viscous liquid with an aromatic, slightly pungent odor (*Merck 1983, *CHRIS 1978) SECTION III -- HEALTH HAZARD DATA OSHA PEL: Air: TWA 0.5 mg/ms (skin) (NIOSH 1987) ACGIH TLV: 0.5 mg/m3 (ACGIH 1986-87) IDLH: 500 mg/ms (*Clayton and Clayton 1981-82) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Gosselin 1984, pp. III-108-109) Skin: Yes — More toxic to humans than by oral administration (Gosselin 1984, pp. III-108-109) Ingestion: Yes (Gosselin 1984, pp. III-108-109) Health Hazards (Acute, Delayed, and Chronic): Fatal oral dose to adult humans is between 6 and 60 g with onset of symptoms within 45 minutes to several hours after ingestion, although symptoms have occurred following very small doses either orally or by skin exposure. Some reports of delayed development of liver disease, blood disorders and upset stomach. Chlordane is considered to be borderline between a moderately and highly toxic substance (Gosselin 1984, pp. III-108-109). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: Flammable/combustible (*DOT 1984) LEL: Not Found UEL: Not Found Extinguishing Methods: Small fires: dry chemical, carbon dioxide, water spray, and foam. Large fires: water spray, fog, or foam. Move containers from fire area if it can be done without risk. Cool containers that are exposed to flames with water from the side until well after fire is out (*DOT 1984). Special Fire Fighting Procedures: Isolate hazard area and deny entry. Stay upwind. Wear positive pressure breathing apparatus and special protective clothing. Isolate for 1/2-mile in all directions if tank car or truck is involved in the fire (*DOT 1984). Unusual Fire and Explosion Hazards: Flammable/combustible material; may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Run-off to sewers may create fire or explosion hazard. Containers may explode in heat of fire. Vapors are toxic indoors ------- CAS Registry Number: 57-74-9 Page 3 of 4 CHLORDANE SECTION IV (continued) and outdoors (*DOT 1984). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Verschueren 1983, pp. 380-381) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Loses chlorine in presence of alkaline reagents; should not be formulated with any solvent, carrier, diluent or emulsifier which has alkaline reaction (*Merck 1983). Hazardous Decomposition or Byproducts: Chlordane degrades under natural environmental conditions to photoisomers, such as photo-cis- chlordane, which are more toxic to certain animals than chlordane and also showed higher bioaccumulation (*Khan et al. 1970). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION As of 1983, the only use in USA is for termite control (*IARC 1972-1985). Previously used as agricultural home and garden pesticide or insecticide (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid breathing vapors (see Section III above). Shut off ignition sources. Eliminate all smoking or flames in hazard area. Do not touch spilled material. Use water spray to reduce vapors. Stay upwind. Small spills: take up with sand or other noncombustible absorbent material, place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 57-74-9 Page 4 of 4 CHLORDANE SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Neoprene GOOD/LIMITED** Nitrile POOR/LIMITED** PVC POOR/LIMITED** Viton GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Increased sensitivity to stimuli, tremors, muscular incoordination, and convulsions with or without coma (Gosselin 1984, pp. 111-108-109). Emergency and First Aid Procedures: Move victim to fresh air and give artificial respiration if indicated. Remove and isolate contaminated clothing and shoes at site. If exposure to skin or eyes, flush with running water for at least 15 minutes. Try to keep victim quiet. Effects may be delayed so keep victim under observation (*DOT 1984). ------- CAS Registry Number: 58-36-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PHENOXARSINE, 10,10'-OXYDI- CAS Registry Number: 58-36-6 Synonyms: (SANSS 1983 Synonyms) lOH-Phenoxarsine, 10,10'-oxybis; Bis(Phenoxarsin-10-yl)Ether; Bis(lO-Phenoxarsinyl) Oxide; Bis(lO-Phenoxarsyl) Oxide; Estabex ABF; OBPA; SA 546; DID 47 Chemical Formula: C24H16As2O3 (Merck 1983, p. 998) Molecular Weight: 502.23 (Merck 1983, p. 998) SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (guinea pig) 24 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): In Arsenic Compounds category SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 363-365°F, 184-185°C (Merck 1983, p. 998) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Practically insoluble (5 ppm at 20°C) (Merck 1983, p. 998) Appearance and Odor: Colorless crystals (Merck 1983, p. 998) ------- CAS Registry Number: 58-36-6 Page 2 of 4 PHENOXARSINE, 10,10'-OXYDI- SECTION III -- HEALTH HAZARD DATA OSHA PEL: 0.010 mg/m3 (Arsenic and Compounds) (NIOSH 1984, p. 661) ACGIH TLV: Air: TWA 0.2 mg (Arsenic)/m3 (ACGIH 1984, p. 10) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Non-Specific - Arsenic Compounds) (Sax 1984, p. 320) Skin: Yes (Non-Specific -- Arsenic Compounds) (Sax 1984, p. 320) Ingestion: Yes (Non-Specific -- Arsenic Compounds) (Sax 1984, p. 320) Health Hazards (Acute, Delayed, and Chronic): (Non-Specific -- Arsenic Compounds) Arsenic compounds are acutely poisonous by ingestion. Ingestion or inhalation may result in chronic poisoning. Arsenic compounds are recognized carcinogens of the skin, lungs, and liver (Sax 1984, p. 320). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Arsenic Compound, Solid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk (DOT 1984, Guide 53). Special Fire Fighting Procedures: (Non-Specific ~ Arsenic Compound, Solid, n.o.s.) Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing (DOT 1984, Guide 53). Unusual Fire and Explosion Hazards: (Non-Specific -- Arsenic Compounds) When heated to decomposition, it emits highly toxic fumes of arsenic (Sax 1984, p. 320). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found ------- CAS Registry Number: 58-36-6 Page 3 of 4 PHENOXARSINE, 10,10'-OXYDI- SECTION V (continued) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION This material is used primarily for fungicidal and bactericidal protection of plastics (Merck 1983, p. 998). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Arsenic Compound, Solid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Do not touch spilled material; stop leak if you can do so without risk. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: (Non-Specific -- Arsenic Compounds) Ingestion causes nausea, vomiting, and diarrhea. In severe cases, there may be bloody vomitus and stools and the victim may suffer collapse and shock with weak, rapid pulse, cold sweats, coma, and death. Symptoms of chronic poisoning may include loss of appetite, cramps, nausea, constipation or diarrhea, jaundice, itching and pigmentation of the skin (Sax 1984, p. 320). ------- CAS Registry Number: 58-36-6 Page 4 of 4 PHENOXARSINE, 10,10'-OXYDI- SECTION IX (continued) Emergency and First Aid Procedures: (Non-Specific — Arsenic Compound, Solid, n.o.s.) Move victim to fresh air; call emergency medical care. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes (DOT 1984, Guide 53). COMMENTS Sources searched but no information found: ACGIH 1983 NIOSH/OSHA 1978 Hawley 1981 Weast 1979 NFPA 1984 Student 1981 Weiss 1980 CHRIS 1978 Doull 1980 Clayton and Clayton 1981-82 Arena 1979 Gosselin 1984 Encyc Occupat Health and Safety 1983 Buchel 1983 Farm Chemicals Handbook 1984 Hayes 1982 Physicians' Desk Reference 1985 Oilman 1985 ------- CAS Registry Number: 58-89-9 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - LINDANE CAS Registry Number: 58-89-9 Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 1,000): Cyclohexane, 1,2,3,4,5,6-Hexachloro-, Gamma-Isomer; Aalindan; Aficide; Agrisol G-20; Agrocide; Agrocide 2; Agrocide 7; Agrocide 6G; Agrocide III; Agrocide WP; Agronexit; Ameisenatod; Ameisenmittel Merck; Aparasin; Aphtiria; Aplidal; Arbitex; BBH; Ben-Hex; Bentox 10; Benzene Hexachloride-gamma-isomer; gamma-Benzene Hexachloride; Bexol; BHC; gamma-BHC; Celanex; Chloresene; Codechine; DBH; Detmol-Extrakt; Detox 25; Devoran; Dol Granule; Drill Tox-Spezial Aglukon; Ent 7,796; Entomoxan; Exagama; Forlin; Gallogama; Gamacid; Gamaphex; Gamene; Gammahexa; Gammahexane; Gammalin; Gammalin 20; Gammaterr; Gammex; Gammexane; Gammopaz; Gexane; HCCH; HCH; gamma-HCH; Heclotox; Hexa; Hexachloran; gamma-Hexachloran; Hexachlorane; gamma- Hexachlorane; gamma-Hexachlorobenzene; l-alpha,2-alpha,3-beta,4-alpha, 5-alpha,6-beta-Hexachlorocyclohexane; gamma-Hexachlorocyclohexane; gamma- 1,2,3,4,5,6-Hexachlorocyclohexane; Hexachlorocyclohexane, gamma-Isomer; 1,2,3,4,5,6-Hexachlorocyclohexane, gamma-Isomer; Hexatox; Hexaverm; Hexicide; Hexyclan; HGI; Hortex; Inexit; Isotox; Jacutin; Kokotine; Kwell; Lendine; Lentox; Lidenal; Lindafor; Lindagam; Lindagrain; Lindagranox; gamma-Lindane; Lindane (DOT); Lindapoudre; Lindatox; Lindosep; Lintox; Lorexane; Milbol 49; Mszychol; NCI-C00204; NEO-Scabicidol; Nexen FB; Nexit; Nexit-Stark; Nexol-E; Nicochloran; Novigam; Omnitox; Ovadziak; Owadzlak; Pedraczak; Pflanzol; Quellada; Sang gamma; Silvanol; Spritz-Rapidin; Spruehpflanzol; Streunex; Tap 85; TRI-6; Viton Chemical Formula: C6H6C16 (Weast 1979, p. C-262) Molecular Weight: 290.83 (Weast 1979, p. C-262) SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (cat) 25 mg/kg (*NIOSH/RTECS 1985) TPQ: 1,000/10,000 (pounds) RQ: 1 (pounds) (statutory); 1 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid ------- CAS Registry Number: 58-89-9 Page 2 of 4 LINDANE SECTION II (continued) Boiling Point: 614°F, 323.4°C (Weast 1979, p. C-262); Decomposes (NIOSH/OSHA 1978, p. 120) Specific Gravity (H2O=1): 1.9 (DASE 1980, p. 529) Vapor Pressure (mmHg): 0.0000094 at 20°C (Merck 1983, p. 789) Melting Point: 234.5°F, 112.5°C (Weast 1979, p. C-262) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (Weast 1979, p. C-262) Appearance and Odor: Colorless solid with a musty odor; pure material is odorless (NIOSH/OSHA 1978, p. 120). SECTION III -- HEALTH HAZARD DATA OSHA PEL: 0.5 mg/m3 (NIOSH/OSHA 1978, p. 120) ACGIH TLV: TWA 0.5 mg/m3 (ACGIH 1986) IDLH: 1,000 mg/m3 (NIOSH/OSHA 1978, p. 120) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Gosselin 1984, p. III-240) Skin: Yes (Gosselin 1984, p. III-240) Ingestion: Yes (Gosselin 1984, p. IH-240) Health Hazards (Acute, Delayed, and Chronic): Lindane is a stimulant of the nervous system, causing violent convulsions that are rapid in onset and generally followed by death or recovery within 24 hours (Hayes 1982, p.218). The probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150-lb (70 kg) person (Gosselin 1984, p. 11-286). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Use dry chemical, carbon dioxide, water spray, or foam for small fires. Use water spray, fog, or foam for large fires. Move container from fire area if this can be done without risk. Use water to ------- CAS Registry Number: 58-89-9 Page 3 of 4 LINDANE SECTION IV (continued) keep fire-exposed containers cool (DOT 1984, Guide 55). Special Fire Fighting Procedures: Isolate hazard area and deny entry. Stay upwind and keep out of low areas. Ventilate closed spaces before entering. Wear positive pressure breathing apparatus and special protective clothing. Fight fire from maximum distance, dike fire control water for later disposal (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition, this compound emits toxic fumes of chlorine, hydrochloric acid, and phosgene (Sax 1984, p. 366). NFPA Flammability Rating: 1 (solution); 0 (dry) SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Thermal decomposition products may include chlorine, hydrochloric acid, and phosgene (Sax 1984, p. 366). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Pesticide (Hawley 1981, p. 617) and scabicide (Hayes 1982, p. 221). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material. Sweep or shovel material into a clean, dry container. Carefully collect remainder (DASE 1980, p. 529; DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 58-89-9 Page 4 of 4 LINDANE SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/LIMITED** Butyl/Neoprene POOR/LIMITED** CPE POOR/LIMITED** Neoprene POOR/LIMITED** Nitrile POOR/LIMITED** PE POOR/LIMITED** PVC POOR/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Contact with eyes or skin may produce irritation (DASE 1980, p. 529). Vomiting, faintness, tremor, restlessness, muscle spasms, unsteady gait, and convulsions may occur as a result of exposure. Elevated body temperature and pulmonary edema have been reported in children. Coma, respiratory failure and death can result. Exposure to vapors of this compound or its thermal decomposition products may lead to headache, nausea, vomiting, and irritation of the eyes, nose, and throat (Gosselin 1984, pp. IH-240, 241). Emergency and First Aid Procedures: Move victim to fresh air and call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes, speed in removing material from the skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effect may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 59-88-1 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PHENYLHYDRAZINE HYDROCHLORIDE CAS Registry Number: 59-88-1 Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 457): Hydrazine, Phenyl-, Hydrochloride; Hydrazine, Phenyl-, Monohydrochloride; Phenylhydrazine Monohydrochloride; Phenylhydrazinium Chloride Chemical Formula: C6H8N2-HC1 Molecular Weight: 144.62 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDlow oral (rabbit) 25 mg/kg (*NIOSH/RTECS 1985). TPQ: 1,000/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not pertinent; it decomposes (Weiss 1980, p. 744) Specific Gravity (H2O=1): Greater than 1 at 20°C (Weiss 1980, p. 744) Vapor Pressure (mmHg): Not Found Melting Point: 469-475°F, 243-246°C (Merck 1983, p. 1051) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Freely soluble (Merck 1983, p. 1051) Appearance and Odor: White to tan solid; weak aromatic odor (Weiss 1980, p. 744). ------- CAS Registry Number: 59-88-1 Page 2 of 3 PHENYLHYDRAZINE HYDROCHLORIDE r SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Occupational exposure to hydrazines recommended standard: ceiling 0.6 mg/ms/2 hours (Air) (Sax 1984, p. 2190). Routes of Entry: Inhalation: Yes (Weiss 1980, p. 744) Skin: Yes (Weiss 1980, p. 744) Ingestion: Yes (Weiss 1980, p. 744) Health Hazards (Acute, Delayed, and Chronic): This material is poisonous if swallowed or if fumes are inhaled. Dust is irritating to eyes, nose, and throat. Phenylhydrazine is a chronic poison (Weiss 1980, p. 744). Phenylhydrazine is an industrial substance suspect of carcinogenic potential for humans (ACGIH 1983, p. 43). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV « FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: Combustible (Weiss 1980, p. 744) LEL: Not Found UEL: Not Found Extinguishing Methods: Use water, foam, dry chemical, or carbon dioxide (Weiss 1980, p. 744). Special Fire Fighting Procedures: Wear goggles and self-contained breathing apparatus (Weiss 1980, p. 744). Unusual Fire and Explosion Hazards: Toxic and irritating hydrogen chloride and oxides of nitrogen may be produced in fire (Weiss 1980, p. 744). NFPA Flammabiiity Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Weiss 1980, p. 744) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): May be corrosive to metals (Weiss 1980, p. 744). ------- CAS Registry Number: 59-88-1 Page 3 of 3 PHENYLHYDRAZINE HYDROCHLORIDE SECTION V (continued) Hazardous Decomposition or Byproducts: Hydrogen chloride and oxides of nitrogen (Weiss 1980, p. 744). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 744) Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Hemolytic (Merck 1983, p. 1051). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid contact with solid and dust. Restrict access. Disperse and flush (Weiss 1980, p. 744). (Non-Specific -- Phenylhy^drazine) Keep unnecessary people away; isolate hazard area a*nd deny entry. Stay upwind; keep out of low areas. Do not touch spilled material; stop leak if you can do it without risk. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Ingestion or inhalation of fumes can cause nausea, jaundice, anorexia, and blood clots. It may also cause anemia and liver injury. Contact with eyes causes irritation. Contact with skin causes irritation and dermatitis. Inhalation of dust can cause coughing and difficult breathing (Weiss 1980, p. 744). Emergency and First Aid Procedures: Move victim to fresh air. Remove contaminated clothing and shoes. For ingestion, give a large amount of water; induce vomiting. If eyes are exposed, flush with water for at least 15 minutes. If skin is exposed, flush with water (Weiss 1980, p. 744). ------- CAS Registry Number: 60-34-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - METHYL HYDRAZINE CAS Registry Number: 60-34-4 Synonyms: 1-Methylhydrazine; Hydrazine, Methyl-; Hydrazomethane; MMH; Monomethylhydrazine; UN 1244 Chemical Formula: CH6N2 Molecular Weight: 46.07 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.105 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 190°F, 87.5°C (*Merck 1983) Specific Gravity (H2O=1): 0.874 at 25°C (*Merck 1983) Vapor Pressure (mmHg): 49.6 at 25°C (*Sunshine 1969) Melting Point: -62.3°F, -52.4°C (*Merck 1983) Vapor Density (AIR=1): 1.6 (*Sax 1979) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Miscible with water (*Merck 1983) Appearance and Odor: It is a colorless liquid (*Sax 1979) with an odor characteristic of short-chain, organic amines, or ammonia-like (*Merck 1983, *Clayton and Clayton 1981-82). ------- CAS Registry Number: 60-34-4 Page 2 of 4 METHYL HYDRAZINE SECTION III - HEALTH HAZARD DATA OSHA PEL: Ceiling 0.35 mg/m3 (skin) (*NIOSH/RTECS 1985) ACGIH TLV: Ceiling 0.35 mg/m3 (skin) (*ACGIH 1983) IDLH: 5 ppm (*Encyc Occupat Safety and Health 1983) Other Limits Recommended: Methyl hydrazine is a suspected human carcinogen with a NIOSH recommended ceiling concentration of 0.08 mg/m3/2 hour (*ACGIH 1984 and *NIOSH 1985). SPEGL 0.24 ppm (60 minutes) (NRC 1985b, pp. 23-36). Routes of Entry: Inhalation: Yes (*Clayton and Clayton 1981-82) Skin: Yes (*Clayton and Clayton 1981-82) Ingestion: Yes (*Clayton and Clayton 1981-82) Health Hazards (Acute, Delayed, and Chronic): Methyl hydrazine vapors are extremely toxic and the liquid is corrosive to skin. Methyl hydrazine is the strongest convulsant and the most toxic of methyl-substituted hydrazine derivatives (*Clayton and Clayton 1981-82). It is more toxic than hydrazine (*NFPA 1978). At high doses, it is a strong central nervous system poison that can lead to convulsions and death (*Encyc Occupat Health and Safety 1971) Medical Conditions Generally Aggravated by Exposure: Skin rash may be aggravated by skin exposure (*Encyc Occupat Health and Safety 1971). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 70°C (OC) (*Merck 1983) Flammable Limits: LEL: 2.5% (Sax 1984, p. 1858) UEL: 97% (Sax 1984, p. 1858) Extinguishing Methods: For small fires, use dry chemical, carbon dioxide, water spray, and foam. For large fires, use water spray, fog, or foam. Keep unnecessary people away and isolate the hazardous area. Stay upwind and keep out of low-lying areas (DOT 1984, Guide 28). Fire exposed containers should be kept cool with water. Use water spray to disperse vapors and protect men attempting to stop a leak which has not ignited (*NFPA 1978). Move container from fire area if it can be done without risk (*DOT 1984). Special Fire Fighting Procedures: Wear positive pressure breathing apparatus and special (full) protective clothing. No skin surface should be exposed (*NFPA 1978). Isolate area for 1/2-mile in all directions if a tank car or truck is involved in a fire (DOT 1984, Guide 28). Unusual Fire and Explosion Hazards: Extremely flammable; ignites spontaneously under almost all normal temperature conditions (*NFPA 1978). Water used to extinguish a fire may cause pollution and should be diked for ------- CAS Registry Number: 60-34-4 Page 3 of 4 METHYL HYDRAZINE SECTION IV (continued) later disposal (DOT 1984, Guide 28). Water may be ineffective in extinguishing fires due to the chemical's low flash point. Because of the wide flammability limits, low flash point, and reignition hazard, dry chemicals, carbon dioxide, water spray, and foam may not be as effective as water dilution of fire area. The vapor is heavier than air; thus it may accumulate sufficiently to flash back (*NFPA 1978). NFPA Flammability Rating: 3 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*NFPA 1978) Stable: Conditions to Avoid: Heat or flame should be avoided because chemical is extremely flammable and explosive (*Sax 1979). Incompatibility (Materials to Avoid): Ignites spontaneously in air when in contact with porous materials (e.g., earth, asbestos, wood, or cloth) (*NFPA 1978). Also ignites spontaneously on contact with strong oxidizing agents (e.g., fluorine, chlorine trifluoride, fuming nitric acid, and nitrogen tetroxide) (*Merck 1983). Hazardous Decomposition or Byproducts: Methylhydrazine fires produce irritating nitrogen oxides (*NFPA 1978). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI ~ USE INFORMATION Used as a chemical intermediate and solvent (*ACGIH 1980). Also used as a component of rocket propellants (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) In the case of a spill or leak, shut off ignition sources, and extinguish or disallow flares, smoking, or flames in the hazard area. Do not touch the spilled material, and stop leak if it can be done without risk. Use water spray to reduce vapors. For small spills, take up the chemical with sand or other noncombustible absorbent material and place it in containers for later disposal. For large spills, dike far ahead for later disposal (*DOT 1984). ------- CAS Registry Number: 60-34-4 Page 4 of 4 METHYL HYDRAZINE SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/MANY CPE POOR/LIMITED Chlorobutyl GOOD/LIMITED PVC POOR/LIMITED Teflon POOR/MANY Viton GOOD/LIMITED *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 60-34-4 Page 1 of 3 Emergency First Aid Treatment Guide for METHYL HYDRAZINE (60-34-4) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Colorless liquid. Odor - Ammonialike. Uses - Chemical intermediate, solvent, rocket propellant. Materials to Avoid - Porous materials, acids, oxidizers. Caution: Extremely flammable. Avoid sources of extreme heat or ignition including sparks or fire. Methyl hydrazine may spontaneously self-ignite. Other Names - Hydrazomethane, 1-methylhydrazine, MMH, monomethylhydrazine, UN 1244. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, phenobarbital, pyridoxine. Signs and Symptoms of Acute Methyl Hydrazine Exposure: Warning: Symptoms may be delayed from hours to days. Caution is advised. Symptoms of acute exposure to methyl hydrazine may include facial numbness, facial swelling, and increased salivation. Headache, twitching, seizure, convulsions, and coma may also occur. Gastrointestinal signs and symptoms include anorexia, nausea, and vomiting. Pulmonary edema and hypotension (low blood pressure) are common. ------- EFATG CAS Registry Number: 60-34-4 Page 2 of 3 METHYL HYDRAZINE Methyl hydrazine is toxic to the liver, ruptures red blood cells, and may cause kidney damage. Contact with the skin, eyes, or mucous membranes may result in severe irritation and permanent damage. Emergency Life-Support Procedures: Acute exposure to methyl hydrazine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to methyl hydrazine. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to methyl hydrazine. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. ------- EFATG CAS Registry Number: 60-34-4 Page 3 of 3 METHYL HYDRAZINE Ingestion Exposure: 1. Evaluate vital signs including .pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. RUSH to a health care facility. ------- CAS Registry Number: 60-41-3 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- STRYCHNINE, SULFATE CAS Registry Number: 60-41-3 Synonyms: (NIOSH/RTECS Synonyms 1983, Volume 3, p. 650) Strychnine, Sulfate (2:1); Strychnine Sulfate; Strychnidin-10-one, Sulfate (2:1) Chemical Formula: C21H22N2O2- 1/2 H2O4S Molecular Weight: 383.49 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 5 mg/kg (*NIOSH/RTECS 1985). TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 392°F, 200°C with decomposition (Merck 1983, p. 1269) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1 g dissolves in 35 mL, 7 mL boiling water (Merck 1983, p. 1269) Appearance and Odor: Colorless, odorless, very bitter crystals; white crystalline powder (Merck 1983, p. 1269). ------- CAS Registry Number: 60-41-3 Page 2 of 3 STRYCHNINE, SULFATE • SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Weiss 1980, p. 1156) Skin: Not Found Ingestion: Yes (Sax 1984, p. 2473) Health Hazards (Acute, Delayed, and Chronic): Violent poison! (Merck 1983, p. 1269). Lowest published lethal dose orally in humans is 30 mg/kg (Weiss 1980, p. 1156). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Strychnine and Salts) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do it without risk (DOT 1984, Guide 53). Special Fire Fighting Procedures: (Non-Specific -- Strychnine and Salts) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing (DOT 1984, Guide 53). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits very toxic fumes of sulfur oxides and nitrogen oxides (Sax 1984, p. 2473). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Protect from light (Merck 1983, p. 1269). Incompatibility (Materials to Avoid): Alkalies, alkali carbonates and ------- CAS Registry Number: 60-41-3 Page 3 of 3 STRYCHNINE, SULFATE SECTION V (continued) bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide (Merck 1983, p. 1269). Hazardous Decomposition or Byproducts: Emits very toxic fumes of sulfur oxides and nitrogen oxides when heated to decomposition (Sax 1984, p. 2473). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Has been used as a tonic and stimulant in veterinary medicine (Merck 1983, p. 1269). Registered as a rodenticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Strychnine and Salts) Do not touch spilled material; stop leak if you can do it without risk. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 60-41-3 Page 1 of 3 Emergency First Aid Treatment Guide for STRYCHNINE SULFATE (60-41-3) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Colorless crystals or white, crystalline powder. Odor - None; bitter taste. Uses - Rodenticide, tonic and stimulant in veterinary medicine. Other Names - Kilmice; Mole-Nots; Mouse-Nots; strychnidin-10-one, sulfate. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, phenobarbital, sodium bicarbonate, pancuronium bromide or curare, succinylcholine. Signs and Symptoms of Acute Strychnine Sulfate Exposure: Warning: Strychnine sulfate may induce convulsions within 15 to 60 minutes following exposure. Caution is advised. Vital signs should be monitored closely. Signs and symptoms of acute exposure to strychnine sulfate generally involve excitation of all portions of the central nervous system. Convulsions, bilateral horizontal nystagmus (rapid, synchronous, horizontal oscillations of the eyeballs), agitation, restlessness, apprehension, and abrupt, jerking movements of the extremities may occur. ------- EFATG CAS Registry Number: 60-41-3 Page 2 of 3 STRYCHNINE SULFATE Victims may also experience stiffness, painful muscle cramping (especially in the legs), opisthotonos (spasm in which the spine and extremities are bent with convexity forward, the body resting on the head and heels), and vomiting. Respiratory paralysis and arrest are likely to occur following severe exposure to strychnine sulfate. Cyanosis (blue tint to skin and mucous membranes), rhabdomyolysis (destruction of skeletal muscle), and renal failure may also be found. Emergency Life-Support Procedures: Acute exposure to strychnine sulfate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to strychnine sulfate. Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions. 2. RUSH to a health care facility! 3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to strychnine sulfate. Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions. 2. RUSH to a health care facility! 3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. ------- EFATG CAS Registry Number: 60-41-3 Page 3 of 3 STRYCHNINE SULFATE 4. Remove contaminated clothing as soon as possible. 5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 6. THOROUGHLY wash exposed skin areas with soap and water. 7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. Warning: Any unnecessary sensory input may induce seizures. Isolate the victims from any avoidable distractions. 2. RUSH to a health care facility! 3. DO NOT induce vomiting or attempt to neutralize. 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. ------- CAS Registry Number: 60-51-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- DIMETHOATE CAS Registry Number: 60-51-5 Synonyms: 8014 Bis HC; Acetic Acid, O,O-DimethyldithiophosphoryI-, N-Mono- methylamide Salt; American Cyanamid 12,880; BI 58; CL 12880; Cygon; Cygon 4E; Cygon Insecticide; Daphene; De-Fend; Demos-L40; Dimethogen; Dimeton; Dimevur; ENT 24650; Experimental Insecticide 12,880; FIP; Fosfotox; Fosfotox R; Fosfotox R 35; Fostion MM; Lurgo; NCI-COO 135; O,O-Dimethyl S-(N-Methyl- carbamoylmethyl) Dithiophosphate; O.O-Dimethyl S-(N-Methylcarbamoylmethyl) Phosphorodithioate; O,O-Dimethyl S-Methylcarbamoylmethyl Phosphorodithioate; O,O-Dimethyldithiophosphorylacetic Acid, N-Monomethylamide Salt; PEI 75; Perfecthion; Perfekthion; Phosphamid; Phosphamide; Phosphorodithioic Acid O,O-Dimethyl Ester, Ester With 2-Mercapto-N-Methylacetamide; Phosphor- odithioic Acid, O,O-Dimethyl S-(2-(Methylamino)-2-Oxoethyl) Ester; Racusan; Rogor; Rogor 20L; Rogor 40; Rogor L; Rogor P; Roxion; S-Methylcarbamoylmethyl O,O-Dimethyl Phosphorodithioate; Sinoratox; Systoate Chemical Formula: C5H12NO3PS2 Molecular Weight: 229.28 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDBO oral (mammal) 15 mg/kg (*NIOSH/RTECS 1985). TPQ: 500/10,000 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 1.277 at 65°C (*Merck 1983) Vapor Pressure (mmHg): 0.0000085 at 77°F ('Worthing 1979) Melting Point: 125°F, 52°C (*Merck-1983), 113-117°F, 45-47°C for technical product (Worthing 1983) . ------- CAS Registry Number: 60-51-5 Page 2 of 4 DIMETHOATE SECTION II (continued) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 2-3 g/100 ml (*Spencer 1982) Appearance and Odor: A white crystalline solid (*Spencer 1982) with a camphor-like odor (*Worthing 1979); white to greyish crystals for technical product (Worthing 1983) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: ADI 0.02 mg/kg (*Hayes 1975). Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and Safety 1983) Skin: Yes (*Encyc Occupat Health and Safety 1983) Ingestion: Yes (*Encyc Occupat Health and Safety 1983) Health Hazards (Acute, Delayed, and Chronic): Very toxic; the probable oral lethal dose in humans is between 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 70 kg (150 Ib.) person. Dimethoate is a cholinesterase inhibitor, meaning it affects the central nervous system. Death is due to respiratory arrest arising from failure of respiratory center, paralysis of respiratory muscles, intense bronchoconstriction or all three (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 124°F (CC) (*NFPA 1978) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: This material is an organophosphate insecticide (*White-Stevens 1971; *Worthing 1979). Methods for organophosphorus pesticides are as follows. Small fires: dry chemical, carbon dioxide, water spray, and foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55). ------- CAS Registry Number: 60-51-5 Page 3 of 4 DIMETHOATE SECTION IV (continued) Special Fire Fighting Procedures: Procedures for organophosphorus pesticides are as follows. Dike fire control water for later disposal, do not scatter the material. Wear positive pressure breathing apparatus and protective clothing. Fight fire from maximum distance (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: As with other organophosphorus pesticides, container may explode in heat of fire (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Stable: Yes (*Spencer 1973) Conditions to Avoid: The temperature of storage should not exceed 70-80°F. Keep away from sources of heat, flames, or spark-generating equipment (*Farm Chemicals Handbook 1983). Unstable in alkaline solution. Hydrolyzed by aqueous alkali. Stable in aqueous solutions. The compound is stable for 2 years under environmental conditions if stored in undamaged, original containers (*Spencer 1973). Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Dimethoate is a contact and systemic organophosphate insecticide effective against a broad range of insects and mites when applied on a wide range of crops (* Worthing 1979; *SRI; * White-Stevens 1971). It has not been produced in the U.S. since 1982 (*SRI). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Dimethoate is an organophosphate insecticide (*White-Stevens 1971; * Worthing 1979). Precautions for organophosphorus pesticides include the following. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material ------- CAS Registry Number: 60-51-5 Page 4 of 4 DIMETHOATE SECTION VII (continued) and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 60-51-5 Page 1 of 3 Emergency First Aid Treatment Guide for DIMETHOATE (60-51-5) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - White crystalline solid. Odor - Camphorlike (familiar, fragrant, penetrating). Commercial Form - White to greyish crystals. Use - Systemic insecticide-acaricide. Material to Avoid - Alkali. Other Names - American Cyanamid 12,880; Cygon; Daphene; Dimet, Dimethogen, O,O-dimethyl S-methylcarbamoylmethyl phosphorodithioate; Dimeton, Dimevur, FIP, Fosfotox, Fostion MM, Lurgo, Perfekthion, Phosphamide, Racusan, Rogor, Roxion, Sinoratox, Systoate. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Dimethoate Exposure: Note: Dimethoate is a cholinesterase inhibitor. Acute exposure to dimethoate may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. ------- EFATG CAS Registry Number: 60-51-5 Page 2 of 3 DIMETHOATE The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) and chest pain may be noted. Hypertension (high blood pressure) is not uncommon. Respiratory effects may include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur. Emergency Life-Support Procedures: Acute exposure to dimethoate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to dimethoate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to dimethoate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. ------- EFATG CAS Registry Number: 60-51-5 Page 3 of 3 DIMETHOATE 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 4. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 5. Transport to a health care facility. ------- CAS Registry Number: 62-38-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PHENYLMERCURY ACETATE CAS Registry Number: 62-38-4 Synonyms: (Acetoxymercuri)Benzene; Acetic Acid, Phenylmercury Deriv; Acetoxyphenylmercury; Agrosan GN 5; Algimycin; Antimucin WDR; Bufen; Ceresan Universal; Contra Creme; Dyanacide; Femma; FMA; Fungitox OR; Gallotox; HL-331; Hostaquick; Kwiksan; Leytosan; Liquiphene; Mercury(II) Acetate, Phenyl-; Mercury, (Acetato)Phenyl-; Mersolite; Mersolite 8; Metasol 30; Norforms; Phenmad; Phenomercuric Acetate; Phenylmercuriacetate; Phenylmercuric Acetate; Phix; PMA; PMAC; PMacetate; PMAL; PMAS; Programing Purasan-SC-10; Puraturf 10; Quicksan 20; Sanitized SPG; SC-110; Shimmerex; Spor-Kil; TAG; Trigosan; Ziarnik; Mercury,(Acetato-O)Phenyl- Chemical Formula: C8H8HgO2 Molecular Weight: 336.75 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 22 mg/kg (*NIOSH/RTECS 1985). TPQ: 500/10,000 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): In Mercury Compounds category SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): 0.000009 at 35°C (*Worthing 1979) Melting Point: 300°F, 149°C (*Merck 1983) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found ------- CAS Registry Number: 62-38-4 Page 2 of 4 PHENYLMERCURY ACETATE SECTION II (continued) Solubility in Water: 1 g/180 ml (*Osol 1980); soluble in about 600 parts water (Merck 1983, p. 1052) Appearance and Odor: White to creamy white crystalline powder or small white prisms or leaflets. Odorless (*Osol 1980). SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: TWA 0.1 mg/m3 (skin) (*ACGIH 1983) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Hawley 1977) Skin: Yes (*Hawley 1977) Ingestion: Yes (*Hawley 1977) Health Hazards (Acute, Delayed, and Chronic): Extremely toxic. The probable oral lethal dose for humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for a 70 kg (150 Ib.) person (Gosselin 1984, p. 11-137). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Above 100°F (OC) (*NFPA 1978) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Use dry chemical, foam, or carbon dioxide on solution. Use water as necessary, but run-off should be limited and controlled to prevent it from entering streams or water supplies (*NFPA 1978). Special Fire Fighting Procedures: Materials are extremely hazardous to health, but areas may be entered with extreme care. Full protective clothing, including self-contained breathing apparatus, rubber gloves, boots and bands around legs, arms, and waist should be provided. No skin should be exposed (*NFPA 1978). Unusual Fire and Explosion Hazards: Fire may produce irritating or poisonous gases (*DOT 1984). NFPA Flammability Rating: 1 (powder); 2 (solution) ------- CAS Registry Number: 62-38-4 Page 3 of 4 PHENYLMERCURY ACETATE SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*NFPA 1978) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Phenylmercuric ion is incompatible with halides, with which precipitates are formed (*Osol 1980). Hazardous Decomposition or Byproducts: When heated to decomposition, very toxic mercuric fumes may be given off (Sax 1984, p. 100). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Used as an antiseptic, fungicide, herbicide; mildewcide for paints; slimicide in paper mills (*Hawley 1977). It was also used in contraceptive gels and foams (*Osol 1980). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms arising from acute exposure may occur at varying intervals up to several weeks following exposure. Ingestion of mercurial fungicide treated grain resulted in gastro-intestinal irritation with nausea, vomiting, abdominal pain, and diarrhea. Alkylmercurials produce severe neurologic toxicity, such as loss of feeling ------- CAS Registry Number: 62-38-4 Page 4 of 4 PHENYLMERCURY ACETATE in lips, tongue, and extremities, confusion, hallucinations, irritability, sleep disturbances, staggering walk, memory loss, slurred speech, auditory defects, emotional instability, and inability to concentrate. It is also a strong skin irritant; erythema and blistering may result 6-12 hours after exposure (*Rumack 1975 to Present). Phenylmercury acetate, at sufficient concentration, is expected to be injurious to the eye externally (*Grant 1974). Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin and eyes with running water for at least 15 minute Speed in removing material from the skin is of extreme importance. Remo' and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep vict under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 62-53-3 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ANILINE CAS Registry Number: 62-53-3 Synonyms: Aminobenzene; Aminophen; Aniline Oil; Anyvim; Benzenamine; Benzene, Amino-; Benzidam; Blue Oil; CI 76000; CI Oxidation Base 1; Cyanol; Krystallin; Kyanol; NCI-C03736; Phenylamine Chemical Formula: C6H7N Molecular Weight: 93.12 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 1,000 (pounds) RQ: 5,000 (pounds) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 363-367°F, 184-186°C (*Merck 1976) Specific Gravity (H2O=1): 1.022 at 20°C/20°C (*Merck 1976) Vapor Pressure (mmHg): 0.67 at 25°C (*IARC 1972-85) Melting Point: 21°F, -6.3°C (*Weast 1979) Vapor Density (AIR=1): 3.22 (*Clayton and Clayton 1981-82) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1 gram in 28.6 mL water (*Merck 1976) ------- CAS Registry Number: 62-53-3 Page 2 of 4 ANILINE SECTION II (continued) Appearance and Odor: Brown oily liquid (*Student 1981) with an aromatic amine-like odor ("CHRIS 1978); colorless when freshly distilled (Merck 1983, p. 96) SECTION III - HEALTH HAZARD DATA OSHA PEL: Air: TWA 5 ppm (19 mg/ms) (skin) (*NIOSH/RTECS 1985) ACGIH TLV: TWA 2 ppm (10 mg/ms) (skin); STEL 5 ppm (20 mg/ms) (skin) ("ACGIH 1982) IDLH: 100 ppm (NIOSH/OSHA 1978, p. 46) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Merck 1976) Skin: Yes (*Merck 1976) Ingestion: Yes (*Merck 1976) Health Hazards (Acute, Delayed, and Chronic): It is classified as very toxic. Probable oral lethal dose in humans is 50-500 mg/kg for a 150 Ib. person. Aniline poisoning is characterized by methemoglobin formation in the blood and resulting cyanosis or blue skin (*Gosselin 1976). The formation of methemoglobin interferes with the oxygen-carrying capacity of the blood (Doull 1980, p. 319). The approximate minimum lethal dose for a 150 Ib. human is 10 grams (*Arena 1979). Serious poisoning may result from ingestion of 0.25 mL (*Merck 1976). Medical Conditions Generally Aggravated by Exposure: People at special , risk-include individuals with glucose-6-phosphate-dehydrogenase deficiency (*Arena 1979) and those with liver and kidney disorders, blood diseases, or a history of alcoholism ("General Electric Co. 1978, MSDS #407). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 158°F, 70°C (CC) (*NFPA 1978) Flammable Limits: LEL: 1.3% (*NFPA 1978) UEL: 20-25% (*Sax 1975) Extinguishing Methods: Use water spray, dry chemical, foam or carbon dioxide. Use water to keep fire-exposed containers cool (*NFPA 1984). Special Fire Fighting Procedures: Fight fire from maximum distance. Dike fire control water for later disposal and do not scatter material (*DOT 1984). If a leak or spill has not ignited, use water spray to control vapors (*NFPA 1978). Wear self-contained breathing apparatus with a full face piece operated in pressure-demand or other positive pressure mode ("NIOSH/OSHA 1981) and special protective clothing ("DOT 1984). ------- CAS Registry Number: 62-53-3 Page 3 of 4 ANILINE SECTION IV (continued) Unusual Fire and Explosion Hazards: Combustion can produce toxic fumes including nitrogen oxides and carbon monoxide (*General Electric Co. 1978, MSDS #407). Aniline vapor forms explosive mixtures with air (*ITI 1982). NFPA Flammability Rating: 2 SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*NFPA 1978) Conditions to Avoid: Heating (*Sax 1975) Incompatibility (Materials to Avoid): It is incompatible with strong oxidizers and strong acids (NIOSH/OSHA 1978, p. 46) and a number of other materials (*Bretherick 1979; *ITI 1982; *Sax 1984). Hazardous Decomposition or Byproducts: When heated to decomposition, it emits highly toxic fumes (*Sax 1975). These fumes may include nitrogen oxides and carbon monoxide (General Electric Co. 1978, MSDS #407). Hazardous Polymerization: May Occur: Yes (*IARC 1972-85) May Not Occur: Conditions to Avoid: Polymerizes to a resinous mass (*IARC 1972-85). SECTION VI - USE INFORMATION Manufacture of dyes, resins, varnishes, perfumes, shoe blacks, vulcanizing rubber; solvent (*Merck 1976); inks, paint removers (*Dreisbach 1977); herbicides, fungicides, explosives, photographic chemicals (*Hawley 1977); isocyanates (*SRI); and rigid polyurethanes (*NIOSH/OSHA 1981). It is a chemical intermediate for dyes and pigments and a number of other materials (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other non-combustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (*DOT 1984). ------- CAS Registry Number: 62-53-3 Page 4 of 4 ANILINE SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl EXCELLENT/MANY Butyl/Neoprene GOOD/LIMITED CPE GOOD/LIMITED* Neoprene POOR/MANY Nitrile POOR/LIMITED PE POOR/MANY PVC POOR/MANY Saranex GOOD/LIMITED Teflon GOOD/LIMITED Viton POOR/MANY Viton/Neoprene GOOD/LIMITED *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 62-53-3 Page 1 of 3 Emergency First Aid Treatment Guide for ANILINE (62-53-3) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Colorless, oily liquid, or solid below -6 degrees C (21 degrees F). Odor - Aromatic, aminelike. Commercial Form - Brown, oily liquid. Uses - Manufacture of resins, rigid polyurethane, varnish, perfume, ink, paint remover, shoe blacks, artificial sweeteners, pesticides, Pharmaceuticals, photographic chemicals, and optical whitening agents; solvent; analytical reagent. Other Names - Aminobenzene, Aminophen, Anyvim, Benzidam, Cyanol, Krystallin, Kyanol, phenylamine. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, diazepam, phenytoin, dopamine, levarterenol, methylene blue. Signs and Symptoms of Acute Aniline Exposure: Signs and symptoms of acute exposure to aniline may be severe and include dyspnea (shortness of breath), respiratory paralysis, cardiac arrhythmias, and cardiovascular collapse. Victims may experience headache, irritability, disorientation, lethargy, weakness, incoordination, dizziness, and drowsiness. Delerium, shock, convulsions, and coma may also be observed. Gastrointestinal effects include dryness of throat, nausea, and vomiting. Painful urination, oliguria (scanty urination), and hematuria (bloody urine) may occur. Aniline may irritate the skin, eyes, and mucous membranes; cyanosis (blue tint to skin and mucous membranes) is a common finding. ------- EFATG CAS Registry Number: 62-53-3 Page 2 of 3 v - ANILINE Emergency Life-Support Procedures: Note: Victims at special risk include individuals with glucose-6-phosphate- dehydrogenase deficiency, those with liver and kidney disorders, blood diseases, or a history of alcoholism. Acute exposure to aniline may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to aniline. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to aniline. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas twice with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. ------- EFATG CAS Registry Number: 62-53-3 Page 3 of 3 ANILINE Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of aniline is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of aniline may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. RUSH to a health care facility. ------- CAS Registry Number: 62-73-7 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - DICHLORVOS CAS Registry Number: 62-73-7 Synonyms: O,O-Dimethyl O-2,2-Dichlorovinyl Phosphate; 2,2-Dichloroethenyl Phosphoric Acid Dimethyl Ester; 2,2-Dichlorovinyl Dimethyl Phosphate; Atgard; Bay-19149; Bibesol; Brevinyl; Brevinyl E50; Canogard; Cekusan; Chlorvinphos; Cyanophos; DDVF; DDVP; DEDEVAP; Deriban; Derribante; Dichlorman; Dichlorovas; Dichlorovos; Dichlorphos; Dimethyl 2,2-Dichloroethenyl Phosphate; Dimethyl 2,2-Dichlorovinyl Phosphate; Divipan; ENT 20738; Equigard; Equigel; Estrosel; Ethenol, 2,2-Dichloro-, Dimethyl Phosphate; Fecama; Herkal; Herkol; Krecalvin; Mafu; Marvex; NCI-COO 113; Nerkol; No-Pest Strip; Nogos; Nuva; O,O-Dimethyl Dichlorovinyl Phosphate; OMS 14; Phosphoric Acid, 2,2-Dichlorovinyl Dimethyl Ester; Phosphoric Acid, 2,2-Dichloroethenyl Dimethyl Ester; Phosvit; Szklarniak; Task; Vapona; Vaponite; 2,2-Dichloroethenyl phosphate; Atgard V; Brevinyl Weedat 0002; Celcusan; Dichlorophos; Dimethyl dichlorovinyl phosphate; Nuvan 100 EC; Unifos; Vapona insecticide; Astrobot; Estrosol; Nuvan; SD1750; Fly fighter; Fly-die; Mopari UN NA 2783; Nogos 50; Nogos G; NSC-6738; OKO; Tap 9vp; Task Tabs; Tenac; UDVF; Unifos 50 EC; Vapona II; Verdican; Verdipor; Vinyl alcohol, 2,2-Dichloro-, Dimethyl Phosphate; Vinylophos Chemical Formula: C4H7C12O4P Molecular Weight: 220.98 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC60 inhalation (mouse) 0.013 mg/liter/4 hours (*NIOSH/RTECS 1985). TPQ: 1,000 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 284°F, 140°C at 20 mmHg (*Merck 1976) Specific Gravity (H2O=1): 1.415 at 25°C/4°C (*Merck 1976) ------- CAS Registry Number: 62-73-7 Page 2 of 4 DICHLORVOS SECTION I (continued) Vapor Pressure (mmHg): 0.01 at 30°C (*Sunshine 1969) Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Approximately 1 g/100 ml (*Merck 1976) Appearance and Odor: Oily colorless to amber liquid with an aromatic chemical odor (*Patty 1963; *NIOSH/OSHA 1981) SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 1 mg/ms (skin) (NIOSH/OSHA 1978, p. 84) ACGIH TLV: TWA 0.1 ppm, 1 mg/ms; STEL 0.3 ppm, 3 mg/ms (*AGGIH 1 IDLH: 200 mg/ms (NIOSH/OSHA 1978, p. 84) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*DOT 1984) Skin: Yes (*DOT 1984) Ingestion: Yes (*DOT 1984) Health Hazards (Acute, Delayed, and Chronic): Dichlorvos is a very tox compound with a probable lethal oral dose in humans between 50 and 50 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 Ib.) person. However, brief exposure (30-60 minutes) to vapor concentrations as high 6.9 mg/liter did not result in clinical signs or depressed serum cholinesterase levels. Toxic changes are typical of organophosphate insecticide poisoning with progression to respiratory distress, respirator? paralysis, and death if there is no clinical intervention (Gosselin 1984, pp. 11-291 and III-336, 337). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Greater than 175°F (no method given) (*> 1978) Flammable Limits: Moderately flammable (NIOSH/OSHA 1978, p. 84: ignite easily (*DOT 1984) LEL: Not Found UEL: Not Found Extinguishing Methods: Water in flooding quantities as fog, alcohol dry chemical, or carbon dioxide (NIOSH/OSHA 1978, p. 84). Do not the material (*DOT 1984). ------- CAS Registry Number: 62-73-7 Page 3 of 4 DICHLORVOS SECTION IV (continued) Special Fire Fighting Procedures: Use self-contained breathing apparatus with a full face piece operated on pressure-demand or other positive pressure mode. Prevent skin contact with protective clothing (*NIOSH/OSHA 1978). Isolate area and deny entry. Fight fire from maximum distance. Dike fire control water for future disposal (*DOT 1984). Unusual Fire and Explosion Hazards: Highly toxic chloride fumes or phosgene may be released when this product burns. Firefighters should take precautions noted above (*Sax 1979). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Yes (*Encyc Occupat Health and Safety 1971) Stable: Conditions to Avoid: Hydrolyzes in water (*Sunshine 1969). Incompatibility (Materials to Avoid): Corrosive to iron and mild steel (*Worthing 1979); acids or acid fumes (*Sax 1979). Hazardous Decomposition or Byproducts: Toxic chloride fumes and phosgene formed if heated to decomposition or on contact with acid or acid fumes (*Sax 1979). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Agricultural insecticide for use on crops, stored products, animals, and premises; insecticide for slow release on pest-strips for pest control in homes and aircraft; anthelmintic for dogs, swine, and horses; botacide for horses; flea collars for dogs (*Gosselin 1976; *Rossoff 1974; *Worthing 1979; *SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Prevent access to area from public by isolating area and denying entry. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leaks if you can do it without risk. Reduce vapors with water spray. Take up small spills with sand or other noncombustible absorbent material for later disposal in cannisters. Dike large spills far ahead of spill for later disposal (*DOT 1984). ------- CAS Registry Number: 62-73-7 Page 4 of 4 DICHLORVOS SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Sweating, twitching, contracted pupils, respiratory distress (tightness in the chest and wheezing), salivation (drooling), lacrimation (tearing), nausea, vomiting, abdominal cramps, diarrhea, involuntary defecation and urination, slurred speech, coma, apnea (cessation of breathing), and death (Doull 1980, pp. 367-368). Emergency and First Aid Procedures: Call emergency medical care. If victim was exposed by inhalation, move to fresh air. If not breathing, give artificial respiration; if breathing is difficult, give oxygen. If exposure was by contact, flush skin or eyes with running water for at least 15 minutes; it is critical to remove the material from the skin as quickly as possible. Also remove contaminated clothing and shoes. Victim should be kept quiet, warm, and observed for delayed effects (*DOT 1984). ------- CAS Registry Number: 62-74-8 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - SODIUM FLUOROACETATE CAS Registry Number: 62-74-8 Synonyms: Acetic Acid, Fluoro-, Sodium Salt; 1080; Compd 1080; Compound No. 1080; Fluoroacetic Acid, Sodium Salt; Fratol; Furatol; Ratbane 1080; SMFA; Sodium Fluoacetate; Sodium Fluoacetic Acid; Sodium Fluoracetate; Sodium Monofluoroacetate; Ten-Eighty; TL 869; Yasoknock Chemical Formula: C2H2FO2Na Molecular Weight: 100.02 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (guinea pig) 0.1 mg/liter/10 minutes (*NIOSH/RTECS 1985). TPQ: 10/10,000 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): 0.0 at 20°C (*ACGIH 1980) Melting Point: 392°F, 200°C (*Weast 1979); decomposes at 392°F, 200°C (*Hawley 1981) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate** 1): Not Found Solubility in Water: 1110 g/liter at 25°C (*Weast 1979) Appearance and Odor: White powder (*Weast 1979); odorless (*Hawley 1981). ------- CAS Registry Number: 62-74-8 Page 2 of 3 SODIUM FLUOROACETATE SECTION II (continued) Usually marketed as water solution containing 0.5 percent Nigrosine as black warning color (*Spencer 1982). SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.05 mg/m3 (skin) (*NIOSH/RTECS 1985) ACGIH TLV: TWA 0.05 mg/m3 (skin); STEL 0.15 mg/m3 (skin) (*ACGIH 1983) IDLH: 5 mg/m3 (NIOSH/OSHA 1978, p. 166) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present) Skin: Yes (*Rumack 1975 to Present) Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): This material is super toxic. The probable oral lethal dose in humans is less than 5 rag/kg, or a taste (less than 7 drops) for a 150-lb. person (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: Not combustible (NIOSH/OSHA 1978, p. 166) LEL: Not Found UEL: Not Found Extinguishing Methods: Use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam (*DOT 1984). Special Fire Fighting Procedures: Stay upwind; keep out of low areas. Wear self-contained, positive pressure breathing apparatus and full protective clothing (*DOT 1984). Unusual Fire and Explosion Hazards*' When heated to decomposition, it emits highly toxic fumes of sodium oxide and fluorides (*Sax 1984). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*NIOSH/OSHA 1978) * Conditions to Avoid: Decomposing heat (*Sax 1984) ------- CAS Registry Number: 62-74-8 Page 3 of 3 SODIUM FLUOROACETATE SECTION V (continued) Incompatibility (Materials to Avoid): None hazardous (NIOSH/OSHA 1978, p. 166) Hazardous Decomposition or Byproducts: When heated to decomposition, it emits fumes of sodium oxide and fluorides (*Sax 1984). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION This material is used for control of predatory animals, coyotes, and rodents (*Farm Chemicals Handbook 1984). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material. Stay upwind; keep out of low areas (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms include nausea, vomiting, diarrhea, hyperactive behavior, convulsions, coma, and ventricular fibrillation. Symptoms are usually seen within one-half hour of exposure, but severe effects may be delayed as long as 20 hours (*Rumack 1975 to Present). Emergency and First Aid Procedures: There is no known specific treatment for fluoroacetate exposure, but generally symptomatic support should be provided (*Rumack 1975 to Present). Move victim to fresh air. Call emergency medical care. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes (*DOT 1984). ------- CAS Registry Number: 62-75-9 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - NITROSODIMETHYLAMINE CAS Registry Number: 62-75-9 Synonyms: N-Nitrosodimethylamine; Dimethyl Nitrosamine; Dimethylamine, N-Nitroso-; Dimethylnitrosamine; Dimethylnitrosoamine; DMN; DMNA; Methanamine, N-Methyl-N-Nitroso-; N,N-Dimethylnitrosamine; N-Methyl-N-Nitrosomethanamine; N-Nitroso-N,N-Dimethylamine; NDMA Chemical Formula: C2H6N2O Molecular Weight: 74.08 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.173 mg/liter/4 hours (*NIOSH/RTECS 1985). TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory); 10 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 304-307°F, 151-153°C (*Merck 1983) Specific Gravity (H20=l): 1.0048 at 20°C/4°C (*Merck 1983) Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR-1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Very soluble (*Merck 1983) Appearance and Odor: Yellow oily liquid (*IARC 1972-1985); faint characteristic odor (*Clayton and Clayton 1982) ------- CAS Registry Number: 62-75-9 Page 2 of 4 NITROSODIMETHYLAMINE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: TWA and STEL: Industrial substance suspected of carcinogenic potential in humans (*ACGIH 1984) IDLH: Not Found Other Limits Recommended: Exposures should be avoided, in so far as possible, or otherwise be kept to an absolute minimum; suspected of carcinogenic potential in humans (*ACGIH 1984). Routes of Entry: Inhalation: Yes ('Sunshine 1969) Skin: Yes (*Sunshine 1969) Ingestion: Yes (*Sunshine 1969) Health Hazards (Acute, Delayed, and Chronic): Extremely high toxicity (*Sunshine 1969). It is a suspected human carcinogen. The lowest lethal oral dose in humans has been reported at 10 mg/kg/80 week intermittent exposure (*NIOSH/RTECS 1985). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Clayton and Clayton 1981, p. 3119) Conditions to Avoid: Exposure to ultraviolet light (Clayton and Clayton 1981, p. 3119). Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits toxic fumes of nitrogen oxides (Sax 1984, pp. 1180-1181). ------- CAS Registry Number: 62-75-9 Page 3 of 4 NITROSODIMETHYLAMINE • SECTION V (continued) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Nitrosodimethylamine was formerly used in the production of rocket fuels. Presently used as an antioxidant, as an additive for lubricants and as a softener of copolymers (Merck 1983, p. 952). It is an intermediate for 1,1-dimethylhydrazine (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation and skin contact (see Section III above). Spills can be absorbed by celite or commercial spill absorbent. After absorbent containing major share of nitrosamine has been picked-up (avoid dusts; do not sweep), surface should be thoroughly cleaned with strong detergent solution. If major spill occurs outside of ventilated area, room should be evacuated and cleanup operation should be carried out by persons equipped with self-contained breathing apparatus (*NRC 1981). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) CPE POOR/LIMITED *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms include nausea, vomiting and malaise (*Cooper 1980). Chronic exposure may cause liver disease with jaundice and swelling (*Hamilton 1984) with low platelet count ("Cooper 1980). Emergency and First Aid Procedures: Establish respiration; prevent absorption; decontaminate with soap and water; for eye exposure, flush with water (*Rumack 1975 to Present). (Poisonous Liquid or Gas, n.o.s.) Move ------- CAS Registry Number: 62-75-9 Page 4 of 4 NITROSODIMETHYLAMINE SECTION IX (continued) victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water '* for at least 15 minutes. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 15). ------- CAS Registry Number: 64-00-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - PHENOL, 3-(l-METHYLETHYL)-, METHYLCARBAMATE CAS Registry Number: 64-00-6 Synonyms (NIOSH/RTECS, 1983, Volume I, p. 832): Carbamic Acid, Methyl-, m-Cumenyl Ester; Carbamic Acid, N-Methyl-, 3-Isopropylphenyl Ester; Compound 10854; m-Cumenol Methylcarbamate; m-Cumenyl Methylcarbamate; ENT 25,500; ENT 25,543; H 5727; H 8757; HER. 5727; Hercules 5727; Hercules AC 5727; HIP; m-Isopropylphenol N-Methylcarbamate; m-Isopropylphenyl Methylcarbamate; m-Isopropylphenyl N-Methylcarbamate; 3-Isopropylphenyl Methylcarbamate; N-Methyl m-Isopropylphenyl Carbamate; N-Methyl 3-Isopropylphenyl Carbamatc; QMS 162; 1PC; Phenol, m-Isopropyl-, Methylcarbamate; UC 10854; Union Carbide 10854; Union Carbide UC-10,854 Chemical Formula: CUH16NO2 Molecular Weight: 193.27 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (guinea pig) 10 mg/kg (*NIOSH/RTECS 1985). TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O»1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 162-165°F, 72-74°C (Hayes 1982, p. 450) Vapor Density (AIR-1): Not Found Evaporation Rate (Butyl acetate-1): Not Found ------- CAS Registry Number: 64-00-6 . „ Page 2 of 4 PHENOL, 3-(l-METHYLETHYL)-, METHYLCARBAMATE SECTION II (continued) Solubility in Water: 85 ppm at 30°C (Hayes 1982, p. 450) Appearance and Odor: Pure white solid without appreciable odor (Hayes 1982, p. 450). SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) (DOT 1984, Guide 55) Skin: Yes (Sax 1984, p. 820) Ingestion: Yes (Sax 1984, p. 820) Health Hazards (Acute, Delayed, and Chronic): It is a cholinesterase inhibitor (Hayes 1982, p. 450). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) Wear positive pressure breathing apparatus and special protective clothing. Move container from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fight fire from maximum distance (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) Container may explode in heat of fire (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 64-00-6 Page 3 of 4 PHENOL, 3-(l-METHYLETHYL)-, METHYLCARBAMATE SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Hayes 1982, p. 450) Conditions to Avoid: Decomposing heat (Sax 1984, p. 820) Incompatibility (Materials to Avoid): Incompatible with alkalis (Hayes 1982, p. 450). Hazardous Decomposition or Byproducts: When heated to decomposition, it emits toxic fumes of nitrogen oxides (Sax 1984, p. 820). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION It is used as an insecticide to protect cotton, fruit, vegetables and field crops (Farm Chemicals Handbook 1984, p. C-236). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) Keep unnecessary people away and stay upwind. Do not touch the material or handle broken packages without protective clothing. Use water spray to reduce vapors. Take up spills with non-combustible absorbent material. For small dry spills, place material in a clean dry container with a clean shovel and cover; remove from site of spill. For large spills dike far ahead for later disposal (DOT 1984, Guide 55; Student 1981, p. 104). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Exposure may result in weakness, dizziness, tightness in the chest, headache, pinpoint pupils, profuse sweating, blurred vision, stomach pain, vomiting, skin rashes, and giddiness (Hayes 1982, p. 451). ------- CAS Registry Number: 64-00-6 Page 4 of 4 PHENOL, 3-(l-METHYLETHYL)-, METHYLCARBAMATE SECTION IX (continued) Emergency and First Aid Procedures: (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water for at least IS minutes. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). COMMENTS: Sources searched but no information found: Weiss 1980 Buchel 1983 Gosselin 1984 Merck 1983 Weast 1979 ------- CAS Registry Number: 64-86-8 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - COLCHICINE CAS Registry Number: 64-86-8 Synonyms: 7-alpha-H-Colchicine; Acetamide, N-(5,6,7,9-Tetrahydro-1,2,3,10- Tetramethoxy-9-oxobenzo[a]heptalen-7-yl); Benzo[a]heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-l,2,3,10-tetramethoxy-; Colchicenos; Colchisol; Colcin; Colsaloid; Condylon; N-Acetyl Trimethylcolchicinic acid, Methyl Ether; NSC 757 Chemical Formula: C22H25NO6 Molecular Weight: 399.43 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDlo oral (dog, cat) 0.125 mg/kg (*NIOSH/RTECS 1985). TPQ: 10/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O»1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 288-302°F, 142-150°C (*Merck 1976) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1 g dissolves in 22 ml (*Merck 1976) Appearance and Odor: Odorless or nearly so (*Hawlcy 1977); pale yellow needles or powder; darkens on exposure to light (*Merck 1976). ------- CAS Registry Number: 64-86-8 Page 2 of 3 COLCHICINE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIHTLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): It is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg, i.e. less than 7 drops for a 70 kg (150 Ib.) person (*Gosselin 1976). Death results from respiratory arrest. The fatal dose varies considerably; as little as 7 mg of colchicine has proved fatal (*Goodman 1975). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Slight fire potential (*Sax 1979). Material is a drug (*SRI), with the following procedures for fires. Extinguish fire using agent suitable for type of surrounding fire. Use water in flooding quantities as fog. Use alcohol foam, carbon dioxide or dry chemical (Student 1981, p. 215). Special Fire Fighting Procedures: For drugs, solid, n.o.s., avoid breathing dusts and fumes from burning material. Keep upwind. Wear boots, protective gloves, and goggles (Student 1981, p. 215). Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Clarke 1975) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found ------- • CAS Registry Number: 64-86-8 Page 3 of 3 COLCHICINE SECTION V (continued) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Colchicine is a drug used to treat gouty arthritis, pseudogout, sarcoidal arthritis and calcific tendinitis (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Precautions for drugs, solid, n.o.s., include the following. Avoid breathing dusts, and fumes from burning materials. Keep upwind. Avoid bodily contact with the material. Wear full protective clothing. Wash away any material which may have contacted the body with copious amounts of water or soap and water (Student 1981, p. 215). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS > For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Burning of throat and skin are prominent symptoms. Nausea, vomiting, diarrhea and abdominal pain may occur several hours after exposure. Shock occurs because of extensive vascular damage. Kidney damage resulting in bloody urine and diminished urine output may occur (*Goodman 1975). Emergency and First Aid Procedures: This material is an alkaloid (Merck 1983, p. 352); first aid for alkaloid exposure is as follows: move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 65-30-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - NICOTINE SULFATE CAS Registry Number: 65-30-5 Synonyms: (S)-3-(l-Methyl-2-Pyrrolidinyl)Pyridine Sulfate (2:1); L-l- Methyl-2-(3-Pyridyl)-Pyrrolidine Sulfate; L-3-( 1 -Methyl-2-Pyrrolidyl)Pyridine Sulfate; Black Leaf 40; Nicotine Sulfate, Solid; Nicotine, Sulfate (2:1); Pyridine, 3-(l-Methyl-2-Pyrrolidinyl)-, (S)-, Sulfate (2:1); Pyrrolidine, l-Methyl-2-(3-Pyridyl)-, Sulfate Chemical Formula: (C10H14N2)2.H2SO4 Molecular Weight: 422.56 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mice) 8.55 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 1.15 at 20°C (solid) (*CHRIS 1978) Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR-1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble in water (*Merck 1976) ------- CAS Registry Number: 65-30-5 Page 2 of 4 NICOTINE SULFATE SECTION II Continued) Appearance and Odor: A six-sided tablet (*Merck 1976) or white crystals; (40% solution - Black Leaf Forty) (Hawley 1981, p. 727). SECTION III - HEALTH HAZARD DATA OSHA PEL; Not Found ACGIH TLV: TWA 0.5 mg (nicotineVm3; STEL 1.5 mg (nicotine)/m3 (skin) (*ACGIH 1982) IDLH: Not Found Other Limits Recommended: TWA for nicotine: 0.5 mg/ms (skin) (OSHA 1984, p. 663). Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Yes (*Sax 1975) Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): It is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg (less than 7 drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). Death is possible from respiratory failure caused by paralysis of the respiratory muscles (*Goodman 1980). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: As for nicotine, extinguish with alcohol foam, dry chemical, or carbon dioxide (Sax 1984, p. 1997). Large fires can be extinguished with water spray, fog, or foam (*DOT 1984). Special Fire Fighting Procedures: Wear positive pressure breathing apparatus and special protective clothing. Dike fire control water; do not scatter the material (*DOT 1984). Unusual Fire and Explosion Hazards: As for nicotine, moderate explosion hazard when exposed to heat or flame (*Sax 1975). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 65-30-5 Page 3 of 4 NICOTINE SULFATE SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Menzie 1969) Conditions to Avoid: Decomposing heat (Sax 1984, p. 1998) Incompatibility (Materials to Avoid): (Non-Specific — Nicotine) Avoid oxidizing materials (Sax 1984, p. 1997). Hazardous Decomposition or Byproducts: When heated to decomposition, emits highly toxic fumes of sulfur oxides and organic fumes (Sax 1984, p. 1998). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION It is used as an insecticide (*Merck 1976) and in veterinary medicine as an anthelmintic and external parasiticide (*Garner 1967). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) To clean up, do not touch spilled material; stop leak if possible. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for disposal. Small dry spill: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Onset of acute poisoning is rapid. Symptoms include nausea, salivation, abdominal pain, vomiting, diarrhea, cold sweat, headache, dizziness, disturbed hearing and vision, mental confusion, marked weakness, faintness and prostration, lowered blood pressure, difficult breathing, and weak, rapid and irregular pulse (*Goodman 1980). Inhalation irritates nose and throat. The liquid form irritates the eyes and (on prolonged contact) skin (*CHRIS 1978). ------- CAS Registry Number: 65-30-5 Page 4 of 4 NICOTINE SULFATE SECTION IX (continued) Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim under observation (*DOT 1984). ------- CAS Registry Number: 66-81-9 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - CYCLOHEXIMIDE CAS Registry Number: 66-81-9 Synonyms: Glutarimide, 3-(2-(3,5-Dimethyl-2-Oxocyclohexyl)-2- Hydroxycthyl)-; 2,6-Piperidinedione, 4-(2-(3,5-Dimethyl-2-Oxocyclohexyl)- 2-Hydroxyethyl)- (1S-(1 alpha(S*), 3 alpha, 5 beta))-; Acti-aid; Acti-Dione-PM (-RZ, -BR, & -S); Actidion; Actidione; Actidione PM; Actispray; beta-(2-(3,5- Dimethyl-2-Oxocyclohexyl)-2-Hydroxyethyl)Glutarimide; Hizarocin; Kaken; Naramycin; Naramycin A; Neocycloheximide; NSC-185; TZA; U 4527 Chemical Formula: C15H2SNO4 Molecular Weight: 281.34 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 2 mg/kg (*NIOSH/RTECS 1985). TPQ: 100/10,000 (pounds) •* RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O»1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 247-250°F, 119.5-121 °C (*Merck 1976) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Moderately soluble (Sax 1984, p. 833); 21 g/liter at 36°F, 2°C (*Merck 1976) ------- CAS Registry Number: 66-81-9 Page 2 of 3 CYCLOHEXIMIDE SECTION II (continued) Appearance and Odor: Colorless crystals (*Spencer 1973). SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Yes (*Rumack 1975 to Present) Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): This material is extremely toxic; the probable oral lethal dose in humans is 5-50 mg/kg, or 7 drops to 1 teaspoonful for a 150-lb. person (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LELr Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Fungicides, Poison B Solid) Use agent suitable for surrounding fire. Use alcohol foam, carbon dioxide, or dry chemical. Use water in flooding quantities as fog (Student 1981, p. 259). Special Fire Fighting Procedures: (Non-Specific — Fungicides, Poison B Solid) Avoid breathing dusts and fumes from burning material. Keep upwind. Wear self-contained breathing apparatus. Avoid bodily contact with the material. Wear full protective clothing (Student 1981, p. 259). Unusual Fire and Explosion Hazards: When exposed to heat, it emits toxic fumes, including nitrogen oxides (Sax 1984, p. 833). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Merck 1976) ------- CAS Registry Number: 66-81-9 Page 3 of 3 CYCLOHEXIMIDE SECTION V (continued) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When exposed to heat, it emits toxic fumes, including nitrogen oxides (Sax 1984, p. 833). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION This material is used as a fungicide (*Merck 1976), and as a medication in cancer therapy (*Rumack 1975 to Present). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Fungicides, Poison B Solid) Avoid breathing dusts. Keep upwind. Avoid bodily contact with the material (Student 1981, p. 259). Material is rapidly inactivated at room temperature by dilute alkali (*Merck 1976). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 66-81-9 Page 1 of 3 Emergency First Aid Treatment Guide for CYCLOHEXIMIDE (66-81-9) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless crystals. Commercial Forms - Oil solution, wettable powder, water-soluble tablets. Uses - Chemotherapy, turf disease control, plant growth regulation, fungicide. Other Names - Acti-aid, Actidione, Actispray, glutarimide, 3-(2-(3,5-dimethyl- 2-oxocyclohexyl)-2-hydroxyethyl)-; Hizarocin, Kaken, Naramycin A. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, hydrocortisone, atropine. Signs and Symptoms of Acute Cycloheximide Exposure: Warning: Effects may be delayed for 6 to 24 hours. Caution is advised. Signs and symptoms of acute exposure to cycloheximide may include increased salivation, nausea, vomiting, diarrhea, and dark, bloodstained stools. Dermal effects may range from erythema (redness) to sloughing. Central nervous system excitement, including tremor, may be noted. Liver and kidney damage, coma, and cardiovascular collapse are also possible. ------- EFATG CAS Registry Number: 66-81-9 Page 2 of 3 CYCLOHEXIMIDE Emergency Life-Support Procedures: Acute exposure to cycloheximide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to cycloheximide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to cycloheximide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 66-81-9 Page 3 of 3 CYCLOHEXIMIDE Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of cycloheximide is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of cycloheximide may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 67-66-3 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - CHLOROFORM CAS Registry Number: 67-66-3 Synonyms: Formyl Trichloride; Freon 20; Methane, Trichloro-; Methane Trichloride; Methenyl Chloride; Methenyl Trichloride; Methyl Trichloride; NCI-CO2686; R-20; R 20 (Refrigerant); TCM; Trichloroform; Trichloromethane Chemical Formula: CHC13 Molecular Weight: 119.39 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 10,000 (pounds) RQ: 5000 (pounds) (statutory); 10 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 143°F, 61.7°C (*Weast 1979) Specific Gravity (H2O=1): 1.4832 at 20°C/4°C (*Weast 1979) Vapor Pressure (mmHg): 100 at 10.4°C (*Sax 1979) Melting Point: -82.3°F, -63.5°C (*Weast 1979) Vapor Density (AIR=1): 4.12 (*Sax 1979) Evaporation Rate (Butyl acetate=l): (Carbon Tetrachloride = 1) 1.18 ('General Electric Co. 1979, MSDS #315) Solubility in Water: 1 mL/200 mL at 25°C (*Merck 1976) ------- CAS Registry Number: 67-66-3 Page 2 of 4 CHLOROFORM SECTION II (continued) Appearance and Odor: A clear, colorless and mobile liquid with a characteristic odor (*IARC 1972-1985). SECTION III - HEALTH HAZARD DATA OSHA PEL: Ceiling 50 ppm (240 mg/m3) (NIOSH 1987, p. 80) ACGIH TLV: TWA 10 ppm (50 mg/m8) (ACGIH 1986-87, p. 13) IDLH: 1,000 ppm (NIOSH/OSHA 1978, p. 68) Other Limits Recommended: NIOSH: 2 ppm 60-minute ceiling; potential occupational carcinogen (NIOSH 1897, p. 80 and Appendix A). Industrial substance suspect of carcinogenic potential for humans (ACGIH 1985, p. 42). EEGL 100.0 ppm (60 minutes) (NRC 1984a, pp. 57-76). Routes of Entry: Inhalation: Yes (*NIOSH 1974) Skin: Yes (*DOT 1984) Ingestion: Yes (*ITI 1982) Health Hazards (Acute, Delayed, and Chronic): It is classified as moderately toxic. Probable oral lethal dose for humans is 0.5 to 5 g/kg (between 1 ounce and 1 pint) for a 150 Ib. person. The mean lethal dose is probably near 1 fluid ounce (44 g) (*Gosselin 1976). It is a human suspected carcinogen (*IARC 1972-1985). Also, it is a central nervous system depressant and a gastrointestinal irritant (*Challen PS et al. 1958. Br J Ind Med 15:243). It has caused rapid death attributable to cardiac arrest and delayed death from liver and kidney damage (*IARC 1972-1985). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): None (*General Electric Co. 1979, MSDS #315) Flammable Limits: LEL: None ('General Electric Co. 1979, MSDS #315) UEL: None ('General Electric Co. 1979, MSDS #315) Extinguishing Methods: Extinguish with dry chemical, carbon dioxide, water spray, fog or foam (*DOT 1984). Special Fire Fighting Procedures: Wear self-contained breathing apparatus and special protective clothing. Move container from fire area. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (*DOT 1984). Unusual Fire and Explosion Hazards: Container may explode in the heat of fire (*DOT 1984). When heated it liberates phosgene (*ITI 1982); hydrogen chloride, chlorine and toxic and corrosive oxides of carbon and chlorine ('General Electric Co. 1979, MSDS #315). ------- CAS Registry Number: 67-66-3 Page 3 of 4 CHLOROFORM SECTION IV (continued) NFPA Flammability Rating: 0 SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*CHRIS 1978) Conditions to Avoid: It develops acidity from prolonged exposure to air and light (*General Electric Co. 1979, MSDS #315). Incompatibility (Materials to Avoid): Chloroform explodes when in contact with aluminum powder or magnesium powder or with alkali metals (e.g., lithium, sodium, and potassium) (*NFPA 1978) and dinitrogen tetroxide. It reacts vigorously with acetone in the presence of potassium hydroxide or calcium hydroxide (*Bretherick 1975). It is oxidized by strong oxidizers such as chromic acid forming phosgene and chlorine (*IARC 1972-1985). It reacts vigorously with triisopropylphosphine (*Bretherick 1975). Hazardous Decomposition or Byproducts: When heated, it emits hydrogen chloride, chlorine, toxic and corrosive oxides of carbon and chlorine (*General Electric Co. 1979, MSDS #315) and phosgene (*ITI 1982). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION It is used as a grain fumigant; solvent for pesticides, adhesives (*IARC 1972-1985) fats, oils, rubbers, alkaloids, waxes (*Merck 1976); chemical intermediate for dyes and pesticides; and a component of cough syrups, toothpastes, and linaments (*SRI). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING .AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remote and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other non-combustible absorbent materal and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (*DOT 1984). ------- CAS Registry Number: 67-66-3 Page 4 of 4 CHLOROFORM SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/LIMITED* Butyl/Neoprene POOR/LIMITED* CPE POOR/MANY Neoprene POOR/MANY Nitrile POOR/MANY PE POOR/MANY PVC POOR/MANY Saranex POOR/MANY Teflon GOOD/LIMITED Viton GOOD/LIMITED Viton/Chlorobutyl GOOD/LIMITED Viton/Neoprene GOOD/LIMITED* *Based on qualitative performance information. "Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms of acute exposure include fainting sensation, vomiting, dizziness, salivation, nausea, fatigue, and headache (*ACGIH 1971-1979). Other symptoms are respiratory depression, coma, kidney damage, and liver damage (*IARC 1972-1985). Liquid in the eye causes tearing and conjunctivitis (*Grant 1974). Symptoms of chronic exposure include loss of appetite, hallucinations, moodiness and physical and mental sluggishness (*NIOSH 1974. Criteria for a recommended standard occupational exposure to chloroform. DHEW Pub NIOSH 75-114). Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; if0^> victim under observation (*DOT 1984). ------- CAS Registry Number: 70-69-9 Page 1 of 3 EPA CHEMICAL PROFILE Date: June 22, 1987 Revision: November 30, 1987 CHEMICAL IDENTITY - PROPIOPHENONE, 4'-AMINO- CAS Registry Number: 70-69-9 Synonyms: l-(4-Aminophenyl)-l-Propanone; p-Aminopropiophenone; PAPP; Paraminopropiophenone; USAF UCTL-1856 Chemical Formula: C9HUNO Molecular Weight: 149.21 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (cat) 5.6 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O»1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 284°F, 140°C (Merck 1983, p. 70) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (Merck 1983, p. 70) Appearance and Odor: Yellow needles (Merck 1983, p. 70) ------- CAS Registry Number: 70-69-9 Page 2 of 3 PROPIOPHENONE, 4'-AMTNO- SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (Sax 1984, p. 245) Health Hazards (Acute, Delayed, and Chronic): Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found ------- CAS Registry Number: 70-69-9 Page 3 of 3 PROPIOPHENONE, 4'-AMINO- SECTION VI - USE INFORMATION Not Found SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Not Found SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Ingestion of large doses can cause cyanosis (Sax 1984, p. 245) Emergency and First Aid Procedures: Not Found COMMENTS Sources searched but no information found: Farm Chemicals Handbook 1984 Hayes 1982 Worthing 1979 Verschueren 1983 Clayton and Clayton 1981-1982 Weiss 1980 Goodman and Oilman 1985 Gosselin 1984 Hawley 1981 ------- CAS Registry Number: 71-63-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - DIGITOXIN CAS Registry Number: 71-63-6 Synonyms: Acedoxin; Card-20(22)-Enolide, 3-((O-2,6-Dideoxy-beta-D-Ribo- Hexopyranosyl-(Hexopyranosyl-(l-4)-2,6-Dideoxy-beta-D-Ribo-Hexopyranosyl)oxy) -14-Hydroxy-, (3beta, 5beta)-; Cardigin; Carditoxin; Cristapurat; Crystalline Digitalin; Crystodigin; Digilong; Digimed; Digimerck; Digisidin; Digitalin; Digitaline Cristallisee; Digitaline Nativelle; Digitoksim; Digitophyllin; Digitoxigenin Tridigitoxoside; Ditaven; Glucodigin; Lanatoxin; Myodigin; Purodigin; Purpurid; Unidigin Chemical Formula: C41H64O13 Molecular Weight: 764.92 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (cat) 0.18 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 493-495°F, 256-257°C (when anhydrous) (*Merck 1976) Vapor Density (AIR=»1): Not Found Evaporation Rate (Butyl acetate-1): Not Found Solubility in Water: 1 g in 100 liters at 20°C (*Merck 1976) ------- CAS Registry Number: 71-63-6 Page 2 of 4 DIGITOXIN SECTION II (continued) Appearance and Odor: White or pale buff microcrystalline powder (*Osol 1975); odorless (Merck 1983, p. 353) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): Material is bioactive and capable of causing cardiac arrythmias and electrolyte imbalances that may be fatal. Death is due to ventricular fibrillation or cardiac standstill (*Gosselin 1976). Material has a high toxicity hazard rating; it may cause death or permanent injury after a very short exposure (*Sax 1979). It is classified as super toxic; an estimated single lethal dose is 3-10 mg (Gosselin 1984, p. 11-252). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Drugs or Medicines, Solid, n.o.s.) Extinguish fire using agent suitable for type of surrounding fire (material itself burns with difficulty.) Use water in flooding quantities as fog. Use alcohol foam, carbon dioxide or dry chemical (Student 1981, p. 215). Special Fire Fighting Procedures: (Non-Specific — Drugs or Medicines, Solid, n.o.s.) Avoid breathing dusts and fumes from burning material. Keep upwind. Wear boots, protective gloves, and goggles (Student 1981, p. 216). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits acrid smoke and irritating fumes (Sax 1984, p. 1035). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 71-63-6 Page 3 of 4 DIGITOXIN SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Material is a cardiotonic drug (*Goodman 1975). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Drugs or Medicines, Solids, n.o.s.) Keep upwind. Avoid bodily contact with the material. Wear full protective clothing. Wash away any material which may have contacted the body with copious amounts of water or soap and water (Student 1981, p. 216). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Nausea and vomiting, headache, malaise, fatigue, weakness, drowsiness, abdominal discomfort are symptomatic of toxicity. Visual disturbances (reduction in visual acuity, illusions of flickering or shimmering lights, abnormal color vision) and emotional disorders (including confusion, disorientation, aphasia, delirium, hallucinations, and rarely convulsions) are also possible toxic effects (*Gosselin 1976; *Grant 1974). Emergency and First Aid Procedures: (Non-Specific -- Medicines, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least IS minutes. Remove and isolate contaminated clothing ------- CAS Registry Number: 71-63-6 Page 4 of 4 DIGITOXIN SECTION IX (continued) and shoes at the site. Keep victim quiet and maintain normal body temperature (DOT 1984, Guide 11). ------- CAS Registry Number: 72-20-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ENDRIN CAS Registry Number: 72-20-8 Synonyms: 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-Hexachloro-6,7-Epoxy- l,4,4a,5,6,7,8,8a-Octahydro-,endo,endo-; Compound 269; Endrex; Endricol; ENT 17,251; Experimental Insecticide 269; Hexachloroepoxyoctahydro-endo,endo- Dimethanonaphthalene; Hexadrin; Mendrin; NCI-C00157; SD 3419; Oktanex; EN 57; 2,7:3,6-Dimethanonaphth[2,3-b]Oxirene, 3,4,5,6,9,9-Hexachloro-1 a,2,2a, 3,6,6a,7,7a-Octahydro-, (la.alpha., 2.beta., 2a.beta., 3.alpha., 6.alpha., 6a.beta., 7.beta., 7a.alpha.)-; Nendrin; 1,2,3,4,10,10-Hexachloro-6,7-epoxy- l,4,4a,5,6,7,8,8a-octahydro-endo,endo-l,4:5,8-dimethanonaphthalene; 1,2,3,4, 10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo-1,4-endo-5,8- dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a- octahydro-l,4:5,8-endo,endo-dimethanonaphthalene; NCI 01565; C00157; Isodrin Epoxide; Endrical Chemical Formula: C12H8C16O Molecular Weight: 380.90 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mouse) 1.37 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 1.7 at 68°F, 20°C (*USEPA 1980) Vapor Pressure (mmHg): 0.0000002 at 77°F, 25°C (*Worthing 1979) Melting Point: Decomposes at 473°F, 245°C (Merck 1983, p. 517) Vapor Density (AIR=1): Not Found ------- CAS Registry Number: 72-20-8 Page 2 of 4 ENDRIN SECTION II (continued) Evaporation Rate (Butyl acetate-1): Not Found Solubility in Water: Practically insoluble (*IARC 1972-1985) Appearance and Odor: White, crystalline solid; light tan color for technical grade (*NFPA 1978). Odorless ("CHRIS 1978) or mild chemical odor for technical grade (*IARC 1972-1985). SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.1 mg/m3 (skin) (*NIOSH/RTECS 1985) ACGIH TLV: TWA 0.1 mg/m3 (skin) (ACGIH 1986-87, p.18) IDLH: 200 mg/m3 (*NIH EPA, OHM/TADS 1984) Other Limits Recommended: STEL 0.5 mg/m3 for 30 minutes (Weiss 1980, p. 402) Routes of Entry: Inhalation: Yes ("USEPA 1980) Skin: Yes (*NFPA 1978) Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): This material is extremely toxic (*Gosselin 1976). It is rapidly absorbed through the skin (*NFPA 1978). Symptoms appear between 20 minutes and 12 hours after exposure (*Gosselin 1976). There is evidence that this material may cause chromosomal damage (*USEPA 1980). Doses of 1 mg/kg can cause symptoms (Sax 1984, p. 1278). It is a suspected carcinogen (Hawley 1981, p. 410). Also, it is a central nervous system depressant and hepatotoxin (Farm Chemicals Handbook 1984, p. C-93). Medical Conditions Generally Aggravated by Exposure: Pregnant women are considered to be at special risk (*USEPA 1980). SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Commercial product may contain flammable liquid with flashpoint 80°F, 27°C (*NIH EPA, OHM/TADS 1984) Flammable Limits: LEL: 1.1% (commercial product) (Weiss 1980, p. 402) UEL: 7.0% (commercial product) (Weiss 1980, p. 402) Extinguishing Methods: Use dry chemical, foam, carbon dioxide ("CHRIS 1978), water spray for solution (*NFPA 1978). Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: Use water to keep fire-exposed containers cool (*NFPA 1978). Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed ------- CAS Registry Number: 72-20-8 Page 3 of 4 ENDRIN SECTION IV (continued) spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: Toxic hydrogen chloride and phosgene may be generated when solution burns (*CHRIS 1978). NFPA Flammability Rating: 1 (solution); 0 (dry) SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*USEPA 1980) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Strong oxidizers, strong acids (*NIH EPA, OHM/TADS 1984), and parathion (Sax 1984, p. 1279) Hazardous Decomposition or Byproducts: Toxic hydrogen chloride and phosgene may be generated when solutions burn (*CHRIS 1978). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not found SECTION VI - USE INFORMATION This material is used primarily as an insecticide for field crops (*Worthing 1979). Only cotton and bird perch uses registered in the U.S. (USEPA/Pesticide Index 1985). SECTION VII ~ PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) For leaks or spills, use water spray to disperse vapor and to flush spills (*NFPA 1978). Liquid containing this material should be absorbed in vermiculite, dry sand, earth (*NIOSH/OSHA 1981). Do not touch spilled material; stop leak if you can do it without risk. Small dry spills: with clean shovel place material into clean, dry container and cover; move con- tainers from spill area. Large spills: dike far ahead of spill for later disposal. Keep unnecessary people away; isolate hazard area and deny entry. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site (DOT 1984, Guide 55). ------- CAS Registry Number: 72-20-8 Page 4 of 4 ENDRIN SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: It can cause death by respiratory arrest. Symptoms include headache, nausea, vomiting, dizziness, tremors, convulsions, loss of consciousness, rise in blood pressure, fever, frothing of the mouth, deafness, coma, and death (*Gosselin 1976, Gosselin 1984, pp. 11-285, III-143). Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 74-83-9 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - METHYL BROMIDE CAS Registry Number: 74-83-9 Synonyms: Brom-o-gas; Bromomethane; Curafume; Dowfume MC-2 Soil Fumigant; Dowfume MC-33; Edco; Embafume; Halon 1001; Haltox; Iscobrome; Kayafume; MB; MBX; MEBR; Metaf ume; Methane, Bromo-; Methogas; Monobromomethane; Pestmaster; Prof ume; R 40B1; Rotox; Terabol; Terr-o-gas 100; Zytox Chemical Formula: CH3Br Molecular Weight: 94.95 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 1,000 (pounds) RQ: 1,000 (pounds) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Gas Boiling Point: 38.4°F, 3.56°C (*Weast 1979) Specific Gravity (H2O=1): Liquid: 1.730 at 0°C/4°C (*Merck 1976) Vapor Pressure (mmHg): 1420 at 20°C (*Merck 1976) Melting Point: -136°F, -93.6°C (*Merck 1976) Vapor Density (AIR»1): 3.27 (*NFPA 1978) Evaporation Rate (Butyl acetate=»l): Not Found Solubility in Water: 1.34 g/100 g at 25°C (*Worthing 1979) ------- CAS Registry Number: 74-83-9 Page 2 of 4 METHYL BROMIDE SECTION II (continued) Appearance and Odor: Colorless gas; usually odorless, but has a sweetish chloroform-like odor at high concentrations (*Merck 1976). SECTION III - HEALTH HAZARD DATA OSHA PEL: Ceiling Concentration 80 mg/ms (20 ppm) (NIOSH 1987,p. 158) ACGIH TLV: TWA 20 mg/ms (5 ppm) (ACGIH 1986-87, p.23) IDLH: 2,000 ppm (NIOSH/OSHA 1978, p. 126) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Gosselin 1976) Skin: Yes (*Gosselin 1976) Ingestion: Not Found Health Hazards (Acute, Delayed, and Chronic): Methyl bromide is a dangerous cumulative poison with delayed symptoms of central nervous system intoxication that may appear as long as several months after exposure (*White-Stevens 1971). High concentrations can produce fatal pulmonary edema. Chronic exposure can cause central nervous system depression and kidney injury (*Merck 1976). It may cause severe and permanent brain damage. Severe neurological signs may appear when there is a sudden exposure to high concentrations following continuous slight exposure (*Encyc Occupat Health and Safety 1971). Methyl bromide has practically no odor or irritating effects and therefore no warning, even at hazardous concentrations (*Clayton and Clayton 1981-82). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): None (*Sax 1979) Flammable Limits: LEL: 10% (*Sax 1979) UEL: 16% (*Sax 1979) Extinguishing Methods: Non-flammable in air; burns in oxygen (*Merck 1976). Use water spray, foam, carbon dioxide, or dry chemical (*NFPA 1978). Special Fire Fighting Procedures: Full protective clothing, including self-contained breathing apparatus, coat, pants, gloves, boots, and bands around legs, arms, and waist should be provided. No skin surface should be exposed (*NFPA 1978). Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits toxic fumes of bromides (*Sax 1979). ------- CAS Registry Number. 74-83-9 Page 3 of 4 METHYL BROMIDE SECTION IV (continued) NFPA Flammability Rating: 1 SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*NFPA 1978) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits toxic fumes of bromides (*Sax 1979). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 603) Conditions to Avoid: Not Found SECTION VI - USE INFORMATION This material is used as an insecticide, rodenticide, fumigant, and nematocide; as a chemical intermediate (*SRI); and as a fire extinguishing agent (""Clayton and Clayton 1981-82). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Remove all ignition sources. Ventilate area of spill or leak, stop flow of gas or remove leaking cylinder to open air and repair leak or allow cylinder to empty. If material is in the liquid form, allow it to vaporize (*NIOSH/OSHA 1981). Stay upwind, keep out of low areas. Use water spray to reduce vapors (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/LIMITED* Neoprene GOOD/LIMITED* ------- CAS Registry Number: 74-83-9 Page 4 of 4 METHYL BROMIDE SECTION VIII (continued) Nitrile GOOD/LIMITED* PE POOR/LIMITED PVC POOR/LIMITED* Saranex GOOD/LIMITED Viton GOOD/LIMITED* *Based on qualitative performance information. "Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 74-83-9 Page 1 of 3 Emergency First Aid Treatment Guide for METHYL BROMIDE (74-83-9) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Colorless, transparent, easily liquefied gas, or volatile liquid. Odor - Usually odorless, chloroformlike odor at higher concentrations. Commercial Forms - 98% pure liquid or gas in steel cylinders. Uses - Organic synthesis, fumigation, fire extinguishing, oil extraction from organic matter, pesticides, ionization chambers. Materials to Avoid - Metals, oxidizers. Other Names - Bromomethane, Curafume, Dowfume, Embafume, Haltox, Iscobrome, Kayafume, Metafume, Methogas, Monobromomethane, Pestmaste, Profume, Rotox, Terabol, Zytox. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, normal saline, D5W, Ringer's lactate, dimercaprol, diazepam, phenytoin, phenobarbital, aminophylline, furosemide. ------- EFATG CAS Registry Number: 74-83-9 Page 2 of 3 METHYL BROMIDE Signs and Symptoms of Acute Methyl Bromide Exposure: Warning: Effects may be delayed for hours to days. Caution is advised. Signs and symptoms of acute exposure to methyl bromide may be severe and include tremors, convulsions, brain hemorrhage, paralysis, coma, and permanent brain damage. Respiratory effects include cough, tachypnea (rapid respiratory rate), pulmonary edema, and respiratory collapse. Cyanosis (blue tint to the skin and mucous membranes), pallor, ventricular fibrillation, and circulatory collapse may also occur. Lethargy, profound weakness, headache, dizziness, mental confusion, slurring of speech, staggering gait, and blurred or double vision are often found. Gastrointestinal signs and symptoms include nausea, vomiting, abdominal pain, and anorexia. Oliguria (scanty urination), anuria (lack of urine formation), kidney hemorrhage, and kidney failure may occur. Contact with methyl bromide may cause dermatitis (red, inflamed skin) and conjunctivitis (red, inflamed eyes). Emergency Life-Support Procedures: Acute exposure to methyl bromide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to methyl bromide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other, invasive procedures. 4. Transport to a health care facility. ------- EFATG CAS Registry Number: 74-83-9 Page 3 of 3 METHYL BROMIDE Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to methyl bromide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas twice with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: No information is available. ------- CAS Registry Number: 74-90-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - HYDROCYANIC ACID CAS Registry Number: 74-90-8 Synonyms: Hydrogen Cyanide; Prussic Acid; Aero Liquid HCN; Cyclon; Cyclone B; Evercyn; Formic Anammonide; Formonitrile; Zaclondiscoids Chemical Formula: HCN Molecular Weight: 27.03 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.357 mg/liter/5 minutes (*NIOSH/RTECS 1985) TPQ: 100 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Gas Boiling Point: 78.1°F, 25.6°C (*Merck 1976) Specific Gravity (H2O«1): 0.699 (liquid) (*Weast.l983) Vapor Pressure (mmHg): 630 (*White-Stevens 1971) Melting Point: 7.9°F, -13.4°C (*Merck 1983) Vapor Density (AIR-1): 0.901 g/1 (*Weast 1983) Evaporation Rate (Butyl acetate=»l): Not Found Solubility in Water: Miscible with water (*Merck 1976) Appearance and Odor: Colorless gas or liquid; bitter almond odor (*Merck 1976; *CHRIS 1978) ------- CAS Registry Number: 74-90-8 Page 2 of 4 HYDROCYANIC ACID SECTION III - HEALTH HAZARD DATA OSHA PEL: 10 ppm (11 mg/m3), as cyanide (NIOSH 1987 p. 138) ACGIH TLV: Ceiling 10 mg/m3 (10 ppm) (skin) (ACGIH 1986-87 p. 20) IDLH: 50 ppm, as cyanide (NIOSH 1987, p. 138) Other Limits Recommended: NIOSH: 5 mg/m3 (4.7 ppm) (CN) 10 minute ceiling (NIOSH 1987, p. 138) Routes of Entry: Inhalation: Yes (*Goodman 1975) Skin: Yes (*Encyc Occupat Health and Safety 1983) Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): It is super toxic. Breathing in a small amount of the gas or swallowing a very small amount may be fatal (*NFPA 1978; *Gosselin 1976). Average fatal dose is 50-60 mg. A few minutes of exposure to 300 ppm may result in death. Exposure to 150 ppm for 1/2 to 1 hour may endanger life (Merck 1983, p. 696). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 0°F, -18°C (CC) (*NFPA 1978) Flammable Limits: LEL: 5.6% (*NFPA 1978) UEL: 40.0% (*NFPA 1978) Extinguishing Methods: Use dry chemicals, alcohol foam, or carbon dioxide (*NFPA 1978). Small fires: let burn unless leak can be stopped immediately. Large fires: water spray, fog or foam. Move container from fire area if you can do it without risk. Stay away from ends of tanks. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Cool container with water using unmanned device until well after fire is out. Isolate area until gas has dispersed (*DOT 1984). Special Fire Fighting Procedures: Firefighting should be done from a safe distance. A few whiffs of gas, or liquid penetrating firefighter's protective clothing, could be fatal. Only special protective clothing should be worn. Water spray should be used to keep containers cool (*NFPA 1978). Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Evacuate area endangered by gas. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire (*DOT 1984). Unusual Fire and Explosion Hazards: Unstabilized hydrocyanic acid may polymerize spontaneously with explosive violence (*Hawley 1981). Flashback along vapor trail may occur (*CHRIS 1978). The explosion hazard is severe when this material is exposed to heat, flame, or oxidizers (*Sax 1975). It ------- CAS Registry Number: 74-90-8 Page 3 of 4 HYDROCYANIC ACID SECTION IV (continued) forms explosive mixtures with air, and will react with water, steam, acid, or acid fumes to produce highly toxic fumes of cyanides. It may decompose explosively upon contact with alkaline material (Sax 1984, p. 1548). NFPA Flammability Rating: 4 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*Hawley 1981) Stable: Conditions to Avoid: Hydrocyanic acid solution is sensitive to light (*Hawley 1977). It may become unstable and subject to explosion if stored for an extended time or exposed to high temperature and pressure ("CHRIS 1978). Avoid heat, flame or oxidizers (Sax 1984, p. 1548). Incompatibility (Materials to Avoid): Acetylaldehyde, alkaline materials, oxidizers, water, steam, acid, and acid fumes (Sax 1984, p. 1548) Hazardous Decomposition or Byproducts: Toxic cyanide fumes (Sax 1984, p. 1548) Hazardous Polymerization: May Occur: Yes (*Hawley 1981) May Not Occur: Conditions to Avoid: Unstabilized hydrocyanic acid may polymerize spontaneously with explosive violence (*Hawley 1981). Can polymerize at 50-60°C or when catalyzed with traces of alkali (Sax 1984, p. 1548). SECTION VI - USE INFORMATION j Hydrogen cyanide is used as a rodent poison and as a fumigant (*Rossoff *1974). It is a chemical intermediate in the manufacture of acrylates, methacrylates, hexamethylenediamine, nitriles, and other materials (*Patty 1963). It is also used in metal polishes, electroplating solutions, and metallurgical and photographic processes (*Gosselin 1976). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Stay upwind; keep out of low areas. Ventilate closed spaces before entering. Use water spray to reduce vapors. Do not touch spilled material; stop leak if you can do it without risk. Shut off ignition; no flares, smoking, or flames in hazard area. Isolate area until gas dispersed (*DOT 1984) ------- .CAS Registry Number: 74-90-8 Page 4 of 4 HYDROCYANIC ACID SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED Neoprene GOOD/LIMITED* PE GOOD/LIMITED PVC POOR/LIMITED Viton GOOD/LIMITED* *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 74-90-8 Page 1 of 4 Emergency First Aid Treatment Guide for HYDROCYANIC ACID (HYDROGEN CYANIDE) (74-90-8) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Caution: Hydrocyanic acid toxicity can occur via ingestion, dermal/eye contact, or inhalation; death may occur within minutes. IMMEDIATELY begin administering 100% oxygen and RUSH victims to a health care facility. Substance Characteristics: Pure Forms - Colorless gas or water-white liquid below -13 degrees C (8 degrees F). Odor - Bitter, almondlike. Commercial Forms - 96 to 99% pure in 2, 5, and 10% solutions with a stabilizer in bottles, steel cylinders, and tank cars. Uses - Rodenticide, fumigant, . chemical intermediate, metallurgy and photography, constituent in metal polishes and electroplating solutions. Other Names - Cyclon, formonitrile, hydrogen cyanide, prussic acid. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium bicarbonate, diazepam, phenytoin. ------- EFATG CAS Registry Number: 74-90-8 Page 2 of 4 HYDROCYANIC ACID (HYDROGEN CYANIDE) Signs and Symptoms of Acute Hydrocyanic Acid Exposure: Warning: Hydrocyanic acid may be fatal if inhaled, swallowed, or absorbed through skin or mucous membranes.- Caution is advised. Signs and symptoms of acute exposure to hydrocyanic acid may include hypertension (high blood pressure) and tachycardia (rapid heart rate), followed by hypotension (low blood pressure) and bradycardia (slow heart rate). Cherry red mucous membranes and blood may be noted. Cardiac arrhythmias and other cardiac abnormalities are common. Cyanosis (blue tint to the skin and mucous membranes) may be observed. Weakness, headache, vertigo (dizziness), agitation, giddiness, salivation, nausea, and vomiting, may be followed by combative behavior, convulsions, paralysis, protruding eyeballs, dilated and unreactive pupils, and coma. Tachypnea (rapid, shallow respirations) or hyperpnea (rapid, deep respirations) may be followed by respiratory depression. Lung hemorrhage and pulmonary edema may also occur. Hydrocyanic acid is may be irritating to the skin, eyes, and mucous membranes. Lacrimation (tearing) and a burning sensation of the mouth and throat are common. Emergency Life-Support Procedures: Acute exposure to hydrocyanic acid may require decontamination and life support for the victims. All exposed persons should be transported to a health care facility as quickly as possible. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to hydrocyanic acid. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with hydrocyanic acid- contaminated persons or their gastric contents can result in self- poisoning. ------- EFATG CAS Registry Number: 74-90-8 Page 3 of 4 HYDROCYANIC ACID (HYDROGEN CYANIDE) 3. RUSH to a health care facility! 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to hydrocyanic acid. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with hydrocyanic acid- contaminated persons or their gastric contents can result in self- poisoning. 3. RUSH to a health care facility! 4. Remove contaminated clothing as soon as possible. 5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 6. Wash exposed skin areas twice with soap and water. 7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with hydrocyanic acid- contaminated persons or their gastric contents can result in self- poisoning. 2. RUSH to a health care facility! ------- EFATG CAS Registry Number: 74-90-8 Page 4 of 4 HYDROCYANIC ACID (HYDROGEN CYANIDE) 3. DO NOT induce vomiting or attempt to neutralize! 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. ------- CAS Registry Number: 74-93-1 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - METHYL MERCAPTAN CAS Registry Number: 74-93-1 Synonyms: Mercaptomethane; Methanethiol; Methyl Sulfhydrate; Thiomethanol; Thiomethyl Alcohol Chemical Formula: CH4S Molecular Weight: 48.11 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LCSO inhalation (mouse) 0.0065 mg/liter/2 hours (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Gas Boiling Point: 42.7°F, 5.95°C (*Merck 1983) Specific Gravity (H2O=1): 0.8665 at 20°C/4°C (*Merck 1983) Vapor Pressure (mmHg): 1 at -90.7°C; 10 at -67.5°C; 40 at -49.2°C; 100 at -34.8°C; 400 at -7.9°C; 760 at 6.8°C (*Weast 1979) Melting Point: -189.4°F, -123°C (*Merck 1983) Vapor Density (AIR-1): 1.66 (*Sax 1984) Evaporation Rate (Butyl acetates!): Not Found Solubility in Water: 23.30 g/liter (*Merck 1983) Appearance and Odor: Water-white liquid when below boiling point, or colorless gas (*Hawley 1981); odor of rotten cabbage (*Merck 1983) ------- CAS Registry Number: 74-93-1 Page 2 of 4 METHYL MERCAPTAN SECTION III - HEALTH HAZARD DATA OSHA PEL: Ceiling 20 mg/ms (10 ppm) 15 minute (NIOSH/OSHA 1978, p. 130) ACGIH TLV: TWA 1 mg/m3 (0.5 ppm) (*ACGIH 1983) IDLH: 400 ppm (*Encyc Occupat Health and Safety 1983) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Weiss 1980, p. 618) Skin: Yes (*Rumack 1975 to Present) Ingestion: Not Found Health Hazards (Acute, Delayed, and Chronic): Can cause death by respiratory paralysis (*ACGIH 1980). It is an eye and respiratory tract irritant. Exposure results in pulmonary edema and hepatic and renal damage (Clayton and Clayton 1981-82, p. 2067). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 0°F, -18°C (*Sunshine 1969) Flammable Limits: LEL: 3.9% (Weiss 1980, p. 618) UEL: 21.8% (Weiss 1980, p. 618) Extinguishing Methods: Small fires: let burn unless leak can be stopped immediately. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk. Stay away from ends of tanks. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Cool container with water using unmanned device until well after fire is out. Isolate area until gas has dispersed (DOT 1984, Guide 13). Preferably let fire burn, stop gas flow. Fires may be extinguished with dry chemical, foam, or carbon dioxide (Weiss 1980, p. 618). Special Fire Fighting Procedures: Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Evacuate area endangered by gas. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire (DOT 1984, Guide 13). Unusual Fire and Explosion Hazards: Combustion produces irritating sulfur dioxide. Flash back along vapor track may occur (*CHRIS 1978), Very dangerous when exposed to heat, flame, or oxidizers. On decomposition it emits highly toxic fumes of sulfur oxides. It will react with water, steam or acids to produce toxic and flammable vapors; and can react vigorously with oxidizing materials (Sax 1984, p. 1764). ------- CAS Registry Number: 74-93-1 Page 3 of 4 METHYL MERCAPTAN SECTION IV (continued) NFPA Flammability Rating: 4 SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*CHRIS 1978) Conditions to Avoid: Direct sunlight, and areas of high fire hazards (*Sax 1968) Incompatibility (Materials to Avoid): Incompatible with mercuric oxide and oxidizing materials (Sax 1984, p. 1764). Hazardous Decomposition or Byproducts: Irritating sulfur dioxide is produced upon combustion (Weiss 1980, p. 618). When heated to decomposition, it emits highly toxic fumes and flammable vapors (Sax 1984, p. 1764). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 618) Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Manufacturing of pesticides (*Merck 1983); chemical intermediate for Pharmaceuticals; dimethyl sulfide; fungicides; methionine; in jet fuels; in preparation of plastics (*SRI); and as a gas odorant to serve as a warning property for odorless but hazardous gases (*Clayton and Clayton 1981-82). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Do not touch spilled material; stop leak if you can do so without risk. Shut off ignition sources; no flares, smoking, or flames in hazard area. Use water spray to reduce vapors. Isolate, area until gas has dispersed (DOT 1984, Guide 13). Avoid breathing vapors (see Section III above). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 74-93-1 Page 4 of 4 METHYL MERCAPTAN SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 74-93-1 Page 1 of 4 Emergency First Aid Treatment Guide for METHYL MERCAPTAN (74-93-1) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Colorless gas, or water-white liquid below 6 degrees C (43 degrees F) or under pressure. Odor - Similar to rotten cabbage. Commercial Form - 98% pure liquefied gas in 180-lb cylinders or tank cars. Uses - Manufacture of pesticides, fungicides, Pharmaceuticals, methionine, dimethyl sulfide, plastics, jet fuels, gas odorant for odorless but hazardous gases. Materials to Avoid - Mercuric oxide, oxidizers, bleaches. Caution: Highly flammable. Cylinders may explode when exposed to high temperatures or fire. Avoid sources of extreme heat or ignition including sparks or fire. Combustion produces irritating sulfur oxides. Other Names - Mercaptomethane, methanethiol, methyl sulfhydrate, thiomethanol, thiomethyl alcohol. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, dopamine, amyl nitrite, sodium nitrite, atropine. ------- EFATG CAS Registry Number: 74-93-1 Page 2 of 4 METHYL MERCAPTAN Signs and Symptoms of Acute Methyl Mercaptan Exposure: Warning: Effects may be delayed. Caution is advised. Signs and symptoms of acute exposure to methyl mercaptan may include fever, cough, shortness of breath, a feeling of tightness and burning in the chest, pulmonary edema, respiratory distress, respiratory paralysis, and respiratory failure/collapse. Headache, loss of the sense of smell, dizziness, staggering gait, and heightened emotions may occur. Memory loss, damage to the central and peripheral nervous systems, tremor, convulsions, and coma may also occur. Gastrointestinal symptoms include difficulty swallowing, redness of the tongue and pharynx, nausea, vomiting, abdominal pain, and diarrhea. Urinary disturbances may also be found. Methyl mercaptan may irritate the eyes and mucous membranes. Emergency Life-Support Procedures: Acute exposure to methyl mercaptan may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to methyl mercaptan. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to methyl mercaptan. ------- EFATG CAS Registry Number: 74-93-1 Page 3 of 4 METHYL MERCAPTAN ,* 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of methyl mercaptan is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of methyl mercaptan may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. ------- EFATG CAS Registry Number: 74-93-1 Page 4 of 4 * METHYL MERCAPTAN 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. RUSH to a health care facility. ------- CAS Registry Number: 75-15-0 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- CARBON DISULFIDE CAS Registry Number: 75-15-0 Synonyms: Carbon Bisulfide; Carbon Bisulphide; Carbon Disulphide; Carbon Sulfide; Dithiocarbonic Anhydride; NCI-C04591; Sulphocarbonic Anhydride; Sulphuret of Carbon; Weeviltox Chemical Formula: CS2 Molecular Weight: 76.13 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 10,000 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 116°F, 46.5°C (*Merck 1983) Specific Gravity (H2O-1): 1.2632 at 20°C/4°C (*Merck 1983) Vapor Pressure (mmHg): 360 at 25°C (*Sunshine 1969) Melting Point: -167°F, -110.8°C (*Weast 1979) Vapor Density (AIR-1): 2.67 (*Merck 1983) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 0.294% at 20°C (*Merck 1983) ------- CAS Registry Number: 75-15-0 Page 2 of 4 CARBON DISULFIDE SECTION II (continued) Appearance and Odor: Mobile clear or faintly yellow liquid; reagent and commercial grades are foul smelling. Pure distillates have sweet, pleasing ethereal odor (*Merck 1983) SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 20 ppm; Ceiling Concentration 30 ppm; Peak Concentration 100 ppm/30 minutes/8 hours (*NIOSH 1985) ACGIH TLV: 30 mg/ms (lOppm) (skin) (*ACGIH 1980) IDLH: 500 ppm (NIOSH/OSHA 1978, p. 60) Other Limits Recommended: NIOSH: 10 hour TWA 1 ppm; Ceiling Concentration 10 ppm/15 minutes (NIOSH 1987 p.72); EEGL 50.0 ppm (60 minutes) (NRC 1984a, pp. 41-56) Routes of Entry: Inhalation: Yes (*NIOSH/RTECS 1985) Skin: Yes (*Gosselin 1976) Ingestion: Yes (*NIOSH/RTECS 1985) Health Hazards (Acute, Delayed, and Chronic): The material affects the central nervous system, cardiovascular system, eyes, kidneys, liver, and skin. It may be absorbed through the skin as a vapor or liquid, inhaled or ingested. The probable oral lethal dose for a human is between 0.5 and 5 g/kg or between 1 ounce and 1 pint (or 1 pound) for a 70 kg (150 Ib.) person (*Gosselin 1976). In chronic exposures, the central nervous system is damaged and results in the disturbance of vision and sensory changes as the most common early symptoms (Sax 1984, p. 641). Lowest lethal dose for humans has been reported at 14 mg/kg or 0.98 grams for a 70 kg person (*NIOSH/RTECS 1985). Medical Conditions Generally Aggravated by Exposure: Alcoholics and those suffering from neuropsychic trouble are at special risk (*LeFaux 1968). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): -22°F, -30°C (CC) (Merck 1983, p. 251) Flammable Limits: LEL: 1.3% (*Merck 1983); 1% (*Sunshine 1969) UEL: 50% (*Merck 1983); 44% (*Sunshine 1969) Extinguishing Methods: Use dry chemical, carbon dioxide or other inert gas. Cooling and blanketing with water spray is effective in case of fires in metal containers or tanks to help prevent reignition by hot surfaces. Foam is ineffective (NFPA 1984, p. 49-27). Special Fire Fighting Procedures: If the vapor concentration exceeds 2 percent by volume or is unknown, self-contained breathing mask with.full face should be used by all persons entering contaminated area ("CHRIS ------- CAS Registry Number: 75-15-0 Page 3 of 4 CARBON BISULFIDE SECTION IV (continued) 1978). Wear special protective clothing. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire (DOT 1984, Guide 28). Unusual Fire and Explosion Hazards: Ignition temperature dangerously low: 212°F, 100°C (Merck 1983, p. 251). Vapors may be ignited by contact with ordinary light bulb (*NPFA 1978); when heated to decomposition, it emits highly toxic fumes of oxides of sulfur (*Sax 1979). NFPA Flammability Rating: 3 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (Merck 1983, p. 251) Stable: Conditions to Avoid: Decomposes on standing for a long time (Merck 1983, p. 251) Incompatibility (Materials to Avoid): Air, rust, halogens, metal azides, metals, oxidants; when exposed to heat or flame reacts violently with aluminum, chlorine, azides, hypochlorite, ethylamine diamine, ethylene imine, fluorine, metallic azides of lithium, potassium, cesium, rubidium and sodium, nitrogen oxides, potassium, zinc and (sulfuric acid plus permanganate) (Sax 1984, p. 641). Hazardous Decomposition or Byproducts: When heated to decomposition, emits highly toxic fumes of sulfur oxides and can react vigorously with oxidizing materials (Sax 1984, p. 642). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Carbon disulfide is used in the manufacture of soil disinfectants and vacuum tubes and is used as a solvent for cleaning and extractions, especially in metal treatment and plating. It is a fumigant for commodities, a corrosion inhibitor, and a polymerization inhibitor for vinyl chloride (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) In case of a spill: (1) remove all ignition sources, (2) ventilate area of spill or leak, and (3) for small quantities, absorb on paper towels. Evaporate the spills in a safe place, such as a fume hood. Large quantities can be reclaimed or collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas-cleaning ------- CAS Registry Number: 75-15-0 Page 4 of 4 CARBON DISULFIDE SECTION VII (continued) device (*NIOSH/OSHA 1981). If carbon disulfide is spilled in water, neutralize with agricultural lime, crushed limestone, or sodium bicarbonate. If dissolved, apply activated carbon at ten times the spilled amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates (Student 1981, p. 106). Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors (DOT 1984, Guide 28). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/MANY CPE POOR/MANY Neoprene POOR/LIMITED* Nitrile POOR/MANY PE POOR/MANY PVC POOR/LIMITED* Teflon POOR/LIMITED Viton EXCELLENT/MANY Viton/Chlorobutyl POOR/MANY *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 75-15-0 Page 1 of 3 Emergency First Aid Treatment Guide for CARBON BISULFIDE (75-15-0) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Clear, colorless, or faintly yellow, mobile liquid. Odor - Slight, sweetly pleasant, ethereal (commercial form is foul smelling). Commercial Form - Azeotrope with water containing 97.2% carbon disulfide in drums or tank cars. Uses - Solvent, chemical intermediate; polymerization inhibitor; corrosion inhibitor; agent in metal treatment; anthelmintic; fumigant; manufacture of soil disinfectants, vacuum tubes, and flotation devices. Caution: Flammable liquid. Avoid sources of extreme heat or ignition including sparks or fire. Other Names - Carbon bisulfide, carbon sulfide, dithiocarbonic anhydride, sulphocarbonic anhydride, Weeviltox. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, alcohol, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, phenobarbitol, Vitamin B6, urea. ------- EFATG CAS Registry Number: 75-15-0 Page 2 of 3 , CARBON DISULFIDE Signs and Symptoms of Acute Carbon Disulfide Exposure: Warning: Effects may be delayed. Caution is advised. Acute exposure to carbon disulfide primarily affects the central nervous system producing signs and symptoms that may include headache, dizziness, difficulty swallowing, nervousness, tremors, mental depression, delirium, psychosis, convulsions, paralysis, and coma. Nausea, vomiting, cyanosis (blue tint to skin and mucous membranes), hypothermia (low body temperature), and peripheral vascular collapse may also occur. Respiratory effects include coughing, dyspnea (shortness of breath), and respiratory failure. Carbon disulfide is a strong skin irritant; dermal exposure may result in severe burns. Eye exposure may cause degeneration of the retina and optic nerve. Pupils may be dilated. Emergency Life-Support Procedures: Acute exposure to carbon disulfide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to carbon disulfide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to carbon disulfide. ------- EFATG ' CAS Registry Number: 75-15-0 Page 3 of 3 t CARBON DISULFIDE 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least IS minutes. 5. Wash exposed skin areas three times. Wash initially with soap and water follow with an alcohol wash, then wash again with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: Children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 75-18-3 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - DIMETHYL SULFIDE CAS Registry Number: 75-18-3 Synonyms: 2-Thiapropane; 2-Thiopropane; Dimethyl Monosulfide; Dimethyl Sulphide; Dimethyl Thioether; DMS, Exact-S; Methane, Thiobis-; Methanethiomethane; Methyl Monosulfide; Methyl Sulphide; Methylthiomethane; Thiobismethane Chemical Formula: C2H6S Molecular Weight: 62.13 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.031 mg/liter (*NIOSH/RTECS 1985) TPQ: 100 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 99.7°F, 37.3°C (*Weast 1979) Specific Gravity (H2O»1): 0.8483 at 20°C/4°C (*Weast 1979) Vapor Pressure (mmHg): 400 mmHg at 18.7°C (Perry, 1984, p. 3-55) Melting Point: -144.9°F, -98.27°C (*Weast 1979) Vapor Density (AIR=1): 2.14 (*Sax 1979) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (*Weast 1979) Appearance and Odor: Colorless liquid with an unpleasant, wild radish, cabbage-like odor (*Fenaroli 1975). ------- CAS Registry Number: 75-18-3 Page 2 of 3 DIMETHYL SULFIDE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Clayton and Clayton 1981-82) Skin: Yes (*Clayton and Clayton 1981-82) Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): Dimethyl sulfide causes softening and irritation of the skin. Orally it is an irritant (*Sax 1975). It is a moderate eye irritant (*Clayton and Clayton 1981-82). It is an eye, nose, throat and skin irritant (*CHRIS 1978). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): -55°F (*Clayton and Clayton 1981-82) Flammable Limits: LEL: 2.2% (*Sax 1979) UEL: 19.7% (*Sax 1979) Extinguishing Methods: Extinguish with dry chemical, carbon dioxide, water spray, fog or foam (*DOT 1984). Special Fire Fighting Procedures: Wear self-contained breathing apparatus and full protective clothing. Move container from fire area. Cool containers that are exposed to flames with water from the side until well after the fire is out. For massive fire in cargo area, used unmanned hose holder or monitor nozzles; if this is impossible withdraw from area and let fire burn. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire (*DOT 1984). Unusual Fire and Explosion Hazards: Flammable/combustible material, may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion hazard indoors, outdoors or in sewers (*DOT 1984). NFPA Flammability Rating: 4 SECTION V ~ REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found ------- CAS Registry Number: 75-18-3 Page 3 of 3 DIMETHYL SULFIDE SECTION V (continued) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Reacts vigorously with oxidizing materials (*Sax 1979). Incompatible with dibenzoyl peroxide (Sax 1984, p. 1201). Hazardous Decomposition or Byproducts: Combustion products include toxic and irritating fumes of sulfur dioxide (Weiss 1980, p. 367). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 367) Conditions to Avoid: Not Found SECTION VI - USE INFORMATION It is a gas odorant, catalyst impregn'ator, solvent for anhydrous mineral salts, flavoring ingredient in foods and beverages, chemical intermediate for solvents and dimethyl sulfoxide (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind. Shut off ignition sources; no flares, smoking or flames in hazard area. Stop leak. Use water spray to reduce vapors. Take up spills with noncombustible absorbent material (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Not Found Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush eyes with running water for at least 15 minutes. Wash skin with soap and water. Remove and isolate contaminated clothing and shoes at the site (*DOT 1984). ------- CAS Registry Number: 75-21-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - ETHYLENE OXIDE CAS Registry Number: 75-21-8 Synonyms: alpha, beta-Oxidoethane; Anprolene; Dihydrooxirene; Dimethylene Oxide; E O; ETO; NCI-C50088; Oxacyclopropane; Oxane; Oxidoethane; 1,2-Epoxyethane; Oxiran; Oxirane; Oxirene, Dihydro-; Oxyfume; Oxyfume 12; T-Gas Chemical Formula: C2H4O Molecular Weight: 44.06 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory); 10 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Gas Boiling Point: 51.3°F, 10.7°C (*Sunshine 1969) Specific Gravity (H2O=1): 0.8222 at 10°C/10°C (*Sunshine 1969) Vapor Pressure (mmHg): 1095 at 20°C (NIOSH/OSHA 1978, p. 100) Melting Point: -170.5°F.-112.5°C (*Sunshine 1969) ' Vapor Density (AIR=1): 1.49 (*Environment Canada 1982) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (*Merck 1976) ------- CAS Registry Number: 75-21-8 Page 2 of 4 ETHYLENE OXIDE SECTION II (continued) Appearance and Odor: Colorless gas at room temperature but a mobile liquid below 12°C (54°F) and has a sweet odor (*Merck 1976; "CHRIS 1978) SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 1 ppm (NIOSH 1987, p. 122) ACGIH TLV: 2 mg/m3 (1 ppm) (*ACGIH 1984) IDLH: 800 ppm (*NIOSH/OSHA 1981) Other Limits Recommended: NIOSH: <0.1 ppm, 8 hour TWA; 5 ppm, 10 minute ceiling (NIOSH 1987 p. 122). Industrial substance suspect of carcinogenic potential for humans - recommended TLV 1 ppm (ACGIH 1984, p. 42). EEGL 20.0 ppm (60 minutes) (NRC 1986, pp. 35-68). Routes of Entry: Inhalation: Yes (*Gilman 1980) Skin: Yes (Sax 1984, p. 1348) Ingestion: Yes (Sax 1984, p. 1348) Health Hazards (Acute, Delayed, and Chronic): It can cause death. Lowest inhalation concentration causing toxic effects is 12500 ppm/10 seconds (*NIOSH/RTECS 1985). It is a strong skin irritant (*CHRIS 1978). Neuro- logical disorders and even death have been reported (*Gilman 1980). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Greater than -18°C (*Sunshine 1969); but less than 0°F (OC) (*CHRIS 1978) Flammable Limits: LEL: 3.0% (*Sax 1975) UEL: 100% (*Sax 1975) Extinguishing Methods: Extinguish with alcohol foam, carbon dioxide, dry chemical or water spray, fog, or foam. Let burn unless leak can be stopped immediately (*DOT 1984). Special Fire Fighting Procedures: Move container from fire area if you can do so without risk. Stay away from ends of tanks. Fight fire from maximum distance. For massive fire in-cargo area, use unmanned hose holder or monitor nozzles; if this is impossible, withdraw from area and let fire burn. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Isolate for 1 mile in all directions if tank car or truck is involved in fire. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear positive pressure breathing apparatus and full protective clothing. Evacuate area endangered by gas (*DOT 1984). ------- CAS Registry Number: 75-21-8 Page 3 of 4 ETHYLENE OXIDE SECTION IV (continued) Unusual Fire and Explosion Hazards: Severe explosion hazard when exposed to heat or flame (Sax 1984, p. 1348). Irritating vapors are generated when heated. Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back (*CHRIS 1978). Vapor forms explosive mixtures with air over a wide range (*NFPA 1978). Liquid is not detonable but the vapor may be readily initiated into explosive decomposition (*Bretherick 1979). NFPA Flammability Rating: 4 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*NFPA 1978) Stable: Conditions to Avoid: Air, heat, acids and bases (Sax 1984, p. 1348); metal or metal chloride catalysts (*NFPA 1978) Incompatibility (Materials to Avoid): Metal fittings containing copper, silver, mercury or magnesium; ammonia (*Bretherick 1979); oxidizing agents; acids, organic bases; amines; certain salts; alcohols; mercaptans (*General Electric Co. 1980, MSDS #433); ferric chloride; magnesium perchlorate; m-nitroaniline; trimethylamine (*ITI 1982); potassium, tin chlorides; alkanethiols; bromoethane; aluminum chloride; aluminum oxide; iron chlorides; and iron oxides (Sax 1984, p. 1348). Hazardous Decomposition or Byproducts: Decomposition products are explosive (*ITI 1982). Hazardous Polymerization: May Occur: Yes (*Sax 1975) May Not Occur: Conditions to Avoid: Acids; covalent halides such as chlorides of aluminum, iron (III), tin (IV); basic materials like alkali hydrides, ammonia, amines, and potassium; catalytically active solids such as aluminum or iron oxides or rust (*Bretherick 1975); chlorides of boron, aluminum, tin, and iron; some carbonates; and metals such as copper and copper alloys (*Patty 1963) SECTION VI - USE INFORMATION Ethylene oxide is a chemical intermediate for ethylene glycol, nonionic surfactants, glycol ethers, ethanolamines, triethylene glycol, and polyethylene glycol (*SRI). Used as a fumigant for foodstuffs and textiles, for sterilizing surgical instruments, and as an agricultural fungicide (Merck 1983, p. 550). Registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985). ------- CAS Registry Number: 75-21-8 Page 4 of 4 ETHYLENE OXIDE SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation and skin contact (see Section III above). Shut off ignition sources; do not allow flares, smoking or flames in the hazard area. Stop leak if you can do so without risk. Use water spray to reduce vapors; do not get water inside container. For small spills flush area with flooding amounts of water. For large spills dike spill for later disposal. (*DOT 1984). SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED* CPE GOOD/LIMITED* Neoprene POOR/LIMITED* Nitrile POOR/MANY PVC POOR/LIMITED* Viton POOR/LIMITED* *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 75-21-8 Page 1 of 3 Emergency First Aid Treatment Guide for ETHYLENE OXIDE (75-21-8) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless gas; mobile liquid below 12 degrees C (54 degrees F) or under pressure. Odor - Sweet, etherlike. Commercial Forms - Mixtures with carbon dioxide or fluorocarbon 12. Uses - Chemical intermediate for ethylene glycol, nonionic surfactants, glycol ethers, ethanolamines, triethylene glycol, polyethylene glycol; fumigant, fungicide, ripening agent for fruits; sterilizing surgical instruments. Materials to Avoid - Acids, alcohols, amines, ammonia, oxidizers, metal catalysts. Caution: Explosion potential is high. Avoid all heat sources including fire. Other Names - Anprolene, dihydrooxirene, 1,2-epoxyethane, oxacyclopropane, oxane, oxidoethane, oxirane, oxyfume. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate. Signs and Symptoms of Acute Ethylene Oxide Exposure: Warning: Ethylene oxide is corrosive to moist tissues. Caution is advised. Signs and symptoms of acute exposure to ethylene oxide may be severe, and include dyspnea (shortness of breath), cough, pulmonary edema, pneumonia, and respiratory failure. Lethargy, headache, dizziness, twitching, convulsions, paralysis, and coma may be observed. Cardiac arrhythmias and cardiovascular collapse may also occur. ------- EFATG CAS Registry Number: 75-21-8 Page 2 of 3 ETHYLENE OXIDE Gastrointestinal effects of acute exposure may include nausea, vomiting, and abdominal pain. Ethylene oxide may severely irritate or burn mucous membranes and moist skin. Eye contact may result in conjunctivitis (red, inflamed eyes) and erosion of the cornea. Emergency Life-Support Procedures: Acute exposure to ethylene oxide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to ethylene oxide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to ethylene oxide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be IMMEDIATELY flushed with lukewarm water for AT LEAST 15 minutes. 5. If liquid is spilled on the skin, allow ethylene oxide to vaporize before washing THOROUGHLY with soap and water. ------- EFATG CAS Registry Number: 75-21-8 Page 3 of 3 ETHYLENE OXIDE 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: children up 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Ethylene oxide generally acts as its own cathartic; however, if deemed necessary, excretion may be promoted by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 75-44-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - PHOSGENE CAS Registry Number: 75-44-5 Synonyms: Carbon Oxychloride; Carbonyl Chloride; CG; Chloroformyl Chloride; NCI-C60219; Carbon Bichloride Oxide; Carbonic Acid Dichloride; Carbonic Bichloride; Carbonyl Bichloride; Phosgen Chemical Formula: CC12O Molecular Weight: 98.92 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 10 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Gas Boiling Point: 47°F, 8.2°C (*Merck 1976) Specific Gravity (H2O=»1): 1.432 at 0°C/4°C (*Merck 1976) Vapor Pressure (mmHg): 1215 at 20°C (*Merck 1976) Melting Point: -180°F, -118°C (*Merck 1976) Vapor Density (AIR=1): 3.4 (*NFPA 1975) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Slightly soluble (*Merck 1976) ------- CAS Registry Number: 75-44-5 Page 2 of 4 PHOSGENE SECTION II (continued) Appearance and Odor: Colorless gas; colorless, fuming liquid; suffocating odor reminiscent of moldy hay (*Merck 1976). In dilute concentration has odor of green corn (*Arena 1974); odor similar to decaying fruit at room temperature (*Encyc Occupat Health and Safety 1971). SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.4 mg/ms (0.1 ppm) (NIOSH 1987, p. 192). ACGIH TLV: TWA 0.4 mg/m3 (0.1 ppm) (ACGIH 1986-87, p. 27). IDLH: 2 ppm (NIOSH 1987, p. 192) \ Other Limits Recommended: NIOSH: 0.1 ppm (10 hour TWA); Ceiling 0.2 ppm for 15 minutes (NIOSH 1987, p. 192). EEGL 0.2 ppm (60 minutes) (NRC 1984b, pp. 69-86). Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Yes (*DOT 1984) Ingestion: Not Found Health Hazards (Acute, Delayed, and Chronic): Phosgene is a lung toxicant that causes damage to the capillaries, bronchioles and. alveoli of the lungs (U.S. Army 1975, p. 3-1) by decomposition to hydrochloric acid. There is little immediate irritant effect upon the respiratory tract, and the warning properties of the gas are therefore very slight. Pulmonary edema, bronchopneumonia and occasionally lung abscesses develop. Degenerative changes in the nerves have been reported as later developments. A concentration of 25 ppm is dangerous for exposures lasting 30-60 minutes and 50 ppm is rapidly fatal after even short exposure (Sax 1984, p. 2210). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Nonflammable (NFPA 1984, p. 49-73). For small fires, use dry chemical or carbon dioxide. Use water spray, fog, or foam for larger fires. Do not get water inside containers. Move container from fire area if you can do so without risk. Stay away from the ends of tanks, and cool exposed containers with water until well after the fire is out. Isolate the area until gas has dispersed (*DOT 1984). Special Fire Fighting Procedures: If necessary to stop flow of gas, use water spray to protect the personnel effecting shutoff. Sodium hydroxide or anhydrous ammonia have been used to neutralize phosgene (*NFPA 1975). ------- CAS Registry Number: 75-44-5 Page 3 of 4 PHOSGENE SECTION IV (continued) Unusual Fire and Explosion Hazards: When heated to decomposition or on contact with water or steam, it will react to produce toxic and corrosive fumes (*Sax 1975). NFPA Flammability Rating: 0 SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes, in steel containers if dry (U.S. Army 1975, P. 3-1) Conditions to Avoid: Moisture (*Sax 1975) Incompatibility (Materials to Avoid): Reacts violently with aluminum; tert-butyl azido formate; 2,4-hexadiyn-l,6-diol; isopropyl alcohol; potassium; sodium; hexafluoro isopropylidene; amino lithium; lithium (Sax 1984, p. 2211). Hazardous Decomposition or Byproducts: When heated to decomposition or on contact with water or steam, it will react to produce toxic and corrosive fumes (*Sax 1975). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Delayed-action military chemical agent (U.S. Army 1975, p. 3-1). Chemical intermediate for toluene diisocyanate, methyl isocyanate, acyl chlorides, diphenylmethane-4,4'-diisocyanate, chloroformate esters, diethyl carbonate, dimethyl carbamoyl chloride, polymethylene polyphenylisocyanate, polycarbonate resins (*SRI); aniline dyes (*Hamilton 1974); pesticides, herbicides, dyes (Hawley 1981, p. 807). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind and keep out of low areas. Ventilate closed spaces before entering. SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, ------- CAS Registry Number: 75-44-5 Page 4 of 4 PHOSGENE SECTION VIII (continued) chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 75-44-5 Page 1 of 3 Emergency First Aid Treatment Guide for PHOSGENE (75-44-5) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Easily liquefied colorless gas or colorless to light yellow liquid. Odor - Strong and stifling when concentrated, haylike in dilute form. Commercial Form - 99% pure liquefied gas. Uses - Organic synthesis; chemical intermediate for isocyanates, acid chlorides, and polycarbonates; pesticides; herbicides; dye manufacture; chemical warfare agent. Materials to Avoid - Active metals, aluminum, alcohol, water (except for use in emergency life support). Caution: Hydrochloric acid will be liberated upon contact with water, steam, or alcohols. A violent reaction will occur following contact with aluminum and active metals. Phosgene will produce toxic and corrosive fumes when heated to decomposition; avoid sources of extreme heat. Other Names - Carbon oxychloride, carbonic acid dichloride, carbonyl chloride, chloroformyl chloride, diphosgene. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, normal saline, D5W, Ringer's lactate, dimercaprol. Signs and Symptoms of Acute Phosgene Exposure: Warning: Effects may be delayed up to 24 hours. Caution is advised. ------- EFATG CAS Registry Number: 75-44-5 Page 2 of 3 PHOSGENE Acute exposure to phosgene may result in severe irritation and burns of the skin, eyes, mucous membranes, and respiratory passages. Cough, dyspnea (shortness of breath), pain in the chest, and severe pulmonary edema may also occur. Cyanosis (blue tint to the skin and mucous membranes) and anxiety may be observed. Emergency Life-Support Procedures: Acute exposure to phosgene may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to phosgene. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to phosgene. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. ------- EFATG CAS Registry Number: 75-44-5 Page 3 of 3 PHOSGENE 7. RUSH to a health care facility. Ingestion Exposure: No information is available. ------- CAS Registry Number: 75-55-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - PROPYLENEIMINE CAS Registry Number: 75-55-8 Synonyms: Aziridine, 2-Methyl-; 2-Methylazacyclopropane; 2-Methylaziridine; 2-Methylethylenimine; Methylethylenimine; Propylenimine; Propylene Imine Chemical Formula: C3H7N Molecular Weight: 57.11 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 19 mg/kg (*NIOSH/RTECS 1985) TPQ: 10,000 (pounds) RQ: 1 (pounds) (statutory) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 151-153°F, 66-67°C (*Encyc Occupat Health and Safety 1983) Specific Gravity (H2O»1): 0.8039-0.8070 at 25°C/25°C (Hawley 1981, p. 865) Vapor Pressure (mmHg): 112 at 20°C (*IARC 1972-1985) Melting Point: -85°F, -65°C (*IARC 1972-1985) Vapor Density (AIR-1): 2.0 (*Encyc Occupat Health and Safety 1983) Evaporation Rate (Butyl acetate** 1): Not Found Solubility in Water: Miscible (*IARC 1972-1985) Appearance and Odor: Colorless, oily liquid with an odor similar to aliphatic amines (i.e., fishy) (*IARC 1972-1985) ------- CAS Registry Number: 75-55-8 Page 2 of 4 PROPYLENEIMINE SECTION III - HEALTH HAZARD DATA OSHA PEL: 5 mg/m3 (2 ppm) (NIOSH 1987, p. 200) ACGIH TLV: TWA 5 mg/ms (2 ppm) (skin) (ACGIH 1986-1987, p. 28) IDLH: 500 ppm (NIOSH 1987, p. 200) Other Limits Recommended: Industrial substance suspect of carcinogenic potential to man (*ACGIH 1983) Routes of Entry: Inhalation: Yes (Hawley 1981, p. 865) Skin: Yes (Hawley 1981, p. 865) Ingestion: Yes (Hawley 1981, p. 865) Health Hazards (Acute, Delayed, and Chronic): Toxic after acute exposure. Can severely irritate eyes, skin, and lungs (*Encyc Occupat Health and Safety 1983). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 25°F (CC) (*ACGIH 1980) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: If material is on fire, use foam, carbon dioxide, or dry chemical (Student 1981, p. 433). Special Fire Fighting Procedures: If material is on fire, do not extinguish fire unless flow can be stopped. Use water in flooding quantities as a "fog" and use to cool all affected containers. Keep material out of water sources and sewers. Build dikes to contain flow as necessary (Student 1981, p. 433). Isolate for 1/2 mile in all directions if tank car or truck is involved in fire (DOT 1984, Guide 30). Unusual Fire and Explosion Hazards: Chemical is extremely flammable; vapors are heavier than air (Student 1981, pp. 433). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Thermally unstable (Student 1981, p. 433) Stable: Conditions to Avoid: Not Found ------- CAS Registry Number: 75-55-8 Page 3 of 4 PROPYLENEIMINE SECTION V (continued) Incompatibility (Materials to Avoid): Acids, strong oxidizers (NIOSH/ OSHA 1978, p. 160) Hazardous Decomposition or Byproducts: Toxic oxides of nitrogen are produced during combustion (Student 1981, p. 433). Hazardous Polymerization: May Occur: Yes (Student 1981, p. 433) May Not Occur: Conditions to Avoid: Contact with acid promotes violent polymerization (Student 1981, p. 433) SECTION VI - USE INFORMATION Propyleneimine is used as a chemical intermediate in the modification of latex surface coating resins, polymers in textile and paper industries, dyes, photography, gelatins, oil additives and organic synthesis. It is a comonomer for polymers with methacrylic acid and esters (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid breathing vapors; avoid bodily contact with the material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap with water. Use water spray to disperse vapors and dilute standing pools of liquid. Keep sparks and flames away. Attempt to stop leak if it can be done without hazard. (Student 1981, p. 433). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION 'Signs and Symptoms of Exposure: Inflammation and blistering of the skin, eye and upper respiratory tract; irritation, nausea, itching, and periodic vomiting. Headache, dizziness, and pain in the temple. Shortness of breath, and increased nasal and laryngeal secretion are seen (*Encyc Occupat Health and Safety 1983). Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If victim is not breathing, give artificial respiration; if breathing is labored, give oxygen. In case of eye/skin contact, immediately flush with water for at least 15 minutes (DOT 1984, ------- CAS Registry Number: 75-55-8 Page 4 of 4 PROPYLENEIMINE SECTION IX (continued) Guide 30). Neutralization with acids (e.g., vinegar, fruit juices) is contraindicated. Avoid vomiting (*Rumack 1975 to Present). ------- CAS Registry Number: 75-56-9 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - PROPYLENE OXIDE CAS Registry Number: 75-56-9 Synonyms: 1,2-Epoxypropane; Epoxypropane; Ethylene Oxide, Methyl-; Methyl Ethylene Oxide; Methyl Oxirane; Methyloxirane; NCI-C50099; Oxirane, Methyl-; Propane, 1,2-Epoxy-; Propane, Epoxy; Propene Oxide; Propylene Epoxide; Propyleneoxide; 1,2-Propylene Oxide Chemical Formula: C3H6O Molecular Weight: 58.08 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 10,000 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 93.61°F, 34.23°C (*Merck 1976) Specific Gravity (H2O=1): 0.859 at 0°C/4°C (*Merck 1976) Vapor Pressure (mmHg): 445 at 20°C (*Sunshine 1969) Melting Point: -169.83°F, -112.13°C (*Merck 1976) Vapor Density (AIR=1): 2.0 (*Clayton and Clayton 1981-82) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 40.5% by weight at 20°C (*Merck 1976) ------- CAS Registry Number: 75-56-9 Page 2 of 4 PROPYLENE OXIDE SECTION II (continued) Appearance and Odor: Colorless liquid (*Merck 1976) with sweet, alcoholic odor like natural gas, ether, or benzene (*Clayton and Clayton 1981-82) SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 240 mg/m3 (100 ppm) (NIOSH 1987, p. 200) ACGIH TLV: TWA 50 mg/ms (20 ppm) (*ACGIH 1983) IDLH: 2000 ppm (NIOSH/OSHA 1978, p. 160) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Yes (*Clayton and Clayton 1981-82) Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): This material is moderately toxic by inhalation and ingestion. It may cause irreversible and reversible changes (*Sax 1975). Skin contact with the material or solutions of the material cause irritation; diluted solutions are more irritating than undiluted materials (*Encyc Occupat Health and Safety 1971). Exposure may cause mild depression of the central nervous system and eye, nasal, and lung irritation (*Rumack 1975 to Present). Contact with the liquid can cause blindness and death. Pulmonary edema may recur up to 2 weeks after exposure (*Morgan 1982). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV — FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): -35°F, -37°C (CC) (*Sunshine 1969) Flammable Limits: LEL: 2.8% (*Sax 1979) UEL: 37% (*Sax 1979) Extinguishing Methods: Extinguish with dry chemical, carbon dioxide, water spray, fog or foam (DOT 1984, Guide 26). Special Fire Fighting Procedures: Firefighting should be done from a safe distance or from a protected location (*NFPA 1978). Wear self- contained (positive pressure if available) breathing apparatus and full protective clothing. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire. Move container from area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out. For massive fire in cargo area, use unmanned hose holder or monitor nozzles; if this is impossible, withdraw from area and let fire burn. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire (DOT 1984, Guide 26). ------- CAS Registry Number: 75-56-9 Page 3 of 4 PROPYLENE OXIDE SECTION IV (continued) Unusual Fire and Explosion Hazards: Vapor is heavier than air and may travel considerable distance to source of ignition and flash back. Vapors form explosive mixture with air. If polymerization takes place in container, there may be a violent rupture of container (*NFPA 1978). Explosion hazard is severe when exposed to flame (*Sax 1979). NFPA Flammability Rating: 4 SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Weiss 1980, p. 787) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Violently reacts with acetylide- forming metals such as copper or copper alloys (*Clayton and Clayton 1981-82); ammonium hydroxide; chlorosulfonic acid; hydrochloric acid; hydrofluoric acid; nitric acid; oleum and sulfuric acid (Sax 1984, p. 1289). Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Yes (*Clayton and Clayton 1981-82) May Not Occur: Conditions to Avoid: Active catalytic surfaces such as anhydrous chlorides of iron, tin, and aluminum; peroxides of iron and aluminum; and alkali metal hydroxides (*NFPA 1987); high temperatures; alkalies; aqueous acids; amines and acidic alcohols (Weiss 1980, p. 787). SECTION VI - USE INFORMATION This material is used primarily as a chemical intermediate for polyurethane polyols, propylene glycol, and dipropylene glycol (*SRI). It is also used for sterilization of packaged foods (*Farm Chemicals Handbook 1983), as a herbicide (*Clayton and Clayton 1981-82), in the preparation of lubricants, surfactants, and oil demulcifiers, and as a fumigant and soil sterilant (*Merck 1976). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Ventilate area of spill or leak. Do not allow the material to enter confined space, such as a sewer, because of the possibility of an explosion (*NIOSH/OSHA 1981). Stop discharge if possible. Stay upwind and use water spray to knock down vapor. Avoid contact with liquid and vapor (Weiss 1980, p. 787). Water spray may be used to flush spills away from exposure and to dilute spills to nonflammable mixture (*NFPA ------- CAS Registry Number: 75-56-9 Page 4 of 4 PROPYLENE OXIDE SECTION VII (continued) 1978). Shut off ignition sources; no flares, smoking, or flames in hazard area. Stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 26). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED Butyl/Neoprene POOR/LIMITED* Neoprcne POOR/LIMITED* Nitrile POOR/LIMITED* PE POOR/MANY PVC POOR/LIMITED* Teflon GOOD/LIMITED Viton POOR/MANY Viton/Neoprene POOR/LIMITED* *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 75-56-9 Page 1 of 3 Emergency First Aid Treatment Guide for PROPYLENE OXIDE (75-56-9) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Colorless liquid or gas above 34 degrees C (94 degrees F). Odor - Sweet, alcohollike. Commercial Form - Mixed with carbon dioxide. Uses - Manufacturer of polyurethane, polyols, propylene glycol, and dipropylene glycol; fumigant; solvent. Materials to Avoid - Acids, alkali, oxidizers, metals. Caution: Flammable liquid. Avoid sources of extreme heat or ignition including sparks or fire. Other Names - Epoxypropane, methyl ethylene oxide, methyl oxirane, propene oxide, propylene epoxide. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, aminophylline, morphine, furosemide, epinephrine, atropine. Signs and Symptoms of Acute Propylene Oxide Exposure: Propylene oxide may irritate or burn the skin, eyes, and respiratory tract. Pulmonary edema may occur up to 2 weeks after exposure. Dermatitis (red, inflamed skin) is common. Other signs and symptoms of acute exposure may include headache, nausea, vomiting, and unconsciousness. Victims may appear as if they are in a drunken stupor. ------- EFATG CAS Registry Number: 75-56-9 Page 2 of 3 PROPYLENE OXIDE Emergency Life-Support Procedures: Acute exposure to propylene oxide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to propylene oxide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to propylene oxide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 75-56-9 Page 3 of 3 PROPYLENE OXIDE Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting or attempt to neutralize! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 75-74-1 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - TETRAMETHYLLEAD CAS Registry Number: 75-74-1 Synonyms: Lead Tetramethyl; Methylplumbane; TML; Tetramethyl Lead Chemical Formula: C4H12Pb Molecular Weight: 267.33 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 100 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): In Lead Compounds category SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 230°F, 110°C at 10 mmHg (*IARC 1972-1985); decomposes above 212°F, 100°C (*NFPA 1975) Specific Gravity (H2O=1): 1.995 (*Weast 1976) Vapor Pressure (mmHg): 22 at 20°C (NIOSH/OSHA 1978, p. 176) Melting Point: -17.5°F, -27.5°C (*Weast 1976) Vapor Density (AIR-1): 6.5 (NFPA 1984, p. 325M-87) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (*IARC 1972-1985) ------- CAS Registry Number: 75-74-1 Page 2 of 3 TETRAMETHYLLEAD SECTION II (continued) Appearance and Odor: Colorless liquid (*Encyc Occupat Health and Safety 1971); dyed red, orange or blue with a slight musty odor (NIOSH/OSHA 1978, p. 176). SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.075 mg (Lead)/m3 (OSHA 1984, p. 663) ACGIH TLV: TWA 0.15 mg (Lead)/m3 (skin) (ACGIH 1986-87, p.30) IDLH: 40 mg(Lead)/m3 (NIOSH 1987, p. 222) Other Limits Recommended: Maximum air concentration: 0.15 mg/m3 (skin) (*Casarett 1975) Routes of Entry: Inhalation: Yes (*NFPA 1975) Skin: Yes (*NFPA 1975) Ingestion: Yes (*NFPA 1975) Health Hazards (Acute, Delayed, and Chronic): Vapors are very toxic. Fatal lead poisoning may occur by ingestion, vapor inhalation or skin absorption (*NFPA 1975). Several cases of acute toxicity, usually in the form of degenerative brain disease, have been described following occupational exposure (*IARC 1972-1985). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 38°C (*IARC 1972-1985) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: On fires in which containers are not exposed, use water spray, dry chemical, foam or carbon dioxide (*NFPA 1975). Special Fire Fighting Procedures: Use water to keep fire exposed containers cool. If leak or spill has not ignited, use water spray to disperse vapors or flush spill (*NFPA 1975). For massive fire in cargo area, use unmanned hose holder or monitor nozzle; if this is impossible withdraw from area and let fire burn (*DOT 1984). Unusual Fire and Explosion Hazards: Thermal decomposition is likely to take the form of vapors at the surface. Rapid decomposition will cause container to explode (*NFPA 1975). Dangerous fire hazard when exposed to heat, flame, or oxidizers (Sax 1984, p. 2546). NFPA Flammability Rating: 3 ------- CAS Registry Number: 75-74-1 Page 3 of 3 TETRAMETHYLLEAD SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Weiss 1980, p. 865) Conditions to Avoid: Fire, heat, physical damage, and strong oxidizers (*NFPA 1975). Starts to decompose at about 212°F (100°C). If confined, may explode or detonate at high temperatures (Weiss 1980, p. 865). Incompatibility (Materials to Avoid): Strong oxidizers such as sulfuryl chloride or potassium permanganate (NIOSH/OSHA 1978, p. 176). Hazardous Decomposition or Byproducts: Toxic gases are generated in fire (Weiss 1980, p. 865). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 865) Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Antiknock additive for gasolines; component of mixed alkyl leads for gasoline additives (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other non-combustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 75-74-1 Page 1 of 3 Emergency First Aid Treatment Guide for TETRAMETHYLLEAD (75-74-1) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless liquid. Odor - Musty or fruity. Commercial Form - Red, orange, or blue liquid. Use - Gasoline additive. Materials to Avoid - Oxidizers. Caution: Flammable liquid. Avoid sources of extreme heat or ignition including sparks or fire. When burned, toxic fumes of lead oxide will be emitted. Other Names - Tetramethylplumbane, TML. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, phenobarbitol, mannitol, dexamethasone. Signs and Symptoms of Acute Tetramethyllead Exposure: Warning: Effects may be delayed for hours to days. Caution is advised. Signs and symptoms of acute exposure to tetramethyllead may be severe and include anxiety, irritability, headache, insomnia, disorientation, violent/frightening dreams, hyperexcitability, delusions, and hallucinations. Muscular weakness, tremor, incoordination, convulsions, cerebral edema, and coma may occur. A metallic taste may be noted. Sneezing, bronchitis, and pneumonia may be noted. Bradycardia (slow heart rate), hypotension (low blood ------- EFATG CAS Registry Number: 75-74-1 Page 2 of 3 TETRAMETHYLLEAD- pressure), hypothermia, and pallor may also occur. Gastrointestinal symptoms include vomiting and diarrhea. Tetramethyllead may irritate moist skin, eyes, and mucous membranes. Emergency Life-Support Procedures: Acute exposure to tetramethyllead may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to tetramethyllead. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to tetramethyllead. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. ------- EFATG CAS Registry Number: 75-74-1 Page 3 of 3 TETRAMETHYLLEAD Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: Children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50. to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. RUSH to a health care facility. ------- CAS Registry Number: 75-77-4 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - TRIMETHYLCHLOROSILANE CAS Registry Number: 75-77-4 Synonyms: Chlorotrimethylsilane; Monochlorotrimethylsilicon; Silane, Chlorotrimethyl-; Silane, Trimethylchloro-; Silicane, Chlorotrimethyl; Silylium, Trimethyl-, Chloride; Trimethyl Chlorosilane; Trimethylsilyl Chloride Chemical Formula: C3H9ClSi Molecular Weight: 108.66 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LCiow inhalation (mouse) 0.5 mg/liter/10 minute (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 135°F, 57°C (*Hawley 1977) Specific Gravity (H2O-1): 0.854 at 25°C (*Hawley 1977) Vapor Pressure (mmHg): Not Found Melting Point: -72°F, -57.7°C (*Weast 1984) Vapor Density (AIR=1): 3.7 (*CHRIS 1978) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Decomposes in water (*Hawley 1977) Appearance and Odor: Colorless liquid (*Hawley 1977), with a sharp hydrochloric acid-like odor (*CHRIS 1978). ------- CAS Registry Number: 75-77-4 Page 2 of 3 TRIMETHYLCHLOROSILANE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present) Skin: Yes (*Hawley 1977; *Rumack 1975 to Present) Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): Similar to other silanes. Toxicity is rated high for inhalation, ingestion and local irritation. May cause death or permanent injury after a very short exposure to small quantities (*Sax 1975). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): -18°F (*Hawley 1977); 0°F (OC) (*CHRIS 1978) Flammable Limits: LEL: 1.8% (*CHRIS 1978) UEL: Not Found Extinguishing Methods: Extinguish with dry chemicals or carbon dioxide. Do not use water or foam. Cool exposed containers with water (*CHRIS 1978). Water spray, fog, or foam may be required to fight large fires. However, trimethylchlorosilane may react violently with water. Do not get water inside containers (*DOT 1984). Special Fire Fighting Procedures: Use acid-vapor-type respirator, rubber gloves, chemical worker's goggles, and other protective equipment as necessary to protect skin and eyes ("CHRIS 1978). Unusual Fire and Explosion Hazards: Violent reaction with water (Sax 1984, p. 2665). Toxic and irritating hydrogen chloride and phosgene may be formed in fires. Difficult to extinguish, re-ignition may occur. Flashback along vapor trail may occur. Containers may explode in fire. Vapor may explode if ignited in enclosed area (CHRIS 1987). NFPA Flammability Rating: 3 SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Weiss 1980, p. 895, *CHRIS 1978) Conditions to Avoid: Avoid contact with water; it readily hydrolyzes, liberating hydrochloric acid ("Hawley 1977). ------- CAS Registry Number: 75-77-4 Page 3 of 3 TRIMETHYLCHLOROSILANE SECTION V (continued) Incompatibility (Materials to Avoid): Reacts with surface moisture, releasing hydrogen chloride, which will corrode common metals and form flammable hydrogen gas ("CHRIS 1978). Hazardous Decomposition or Byproducts: When heated to decomposition or on contact with acids or acid fumes, chloride fumes are emitted (*Sax 1979). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 895) Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Chemical intermediate for silicone fluids, silylating agent, and a component of a catalyst for propylene oxide (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid breathing vapors (see Section III above). In case of spill or leak, shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled material. Stop leak if you can do it without risk. Do not get water inside container. For small spills, take up with sand or other non-combustible absorbent material and place into container for later disposal. For large spills, dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number 75-77-4 Page 1 of 3 Emergency First Aid Treatment Guide for TRIMETHYLCHLOROSILANE (75-77-4) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless liquid. Odor - Sharp, acrid. Commercial Form - 98% pure liquid. Uses - Catalyst, solvent, silylating agent, manufacture of silicone fluids. Material to Avoid - Water (except for use in emergency life support). Caution: Highly flammable. Avoid sources of extreme heat or ignition including sparks or fire. Other Names - Chlorotrimethylsilane, trimethylsilyl chloride. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W, Ringer's lactate. Signs and Symptoms of Acute Trimethylchlorosilane Exposure: Warning: In the presence of water, trimethylchlorosilane liberates hydrochloric acid, which is extremely corrosive. Caution is advised. Signs and symptoms of acute trimethylchlorosilane exposure may include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. Vomitus generally has a coffee-ground appearance. ------- EFATG CAS Registry Number: 75-77-4 Page 2 of 3 TRIMETHYLCHLOROSILANE Acute inhalation exposure may result in hoarseness, laryngitis, a feeling of suffocation, dyspnea (shortness of breath), choking, respiratory tract irritation, chest pain, and pulmonary edema. The potential for circulatory collapse is high following ingestion of trimethylchlorosilane. Sneezing, bleeding of the nose and gums, and ulceration of the nasal and oral mucosa may also occur. Renal toxicity has been observed in animals. If the eyes come in contact with trimethylchlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermal exposure is generally followed by dermatitis (red, inflamed skin), severe burns, pain, and shock. Emergency Life-Support Procedures: Acute exposure to trimethylchlorosilane may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to trimethylchlorosilane. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to trimethylchlorosilane. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. ------- EFATG CAS Registry Number: 75-77-4 Page 3 of 3 TRIMETHYLCHLOROSILANE 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Rinse mouth with large amounts of water. Inform victims not to swallow this water. 3. DO NOT induce vomiting or attempt to neutralize! 4 Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal is of no value. 6. Give the victims water or milk: Children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 7. RUSH to a health care facility. ------- CAS Registry Number: 75-78-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - DIMETHYLDICHLOROSILANE CAS Registry Number: 75-78-5 Synonyms: Dichlorodimethylsilane; Dichlorodimethylsilicon; Inerton AW-DMCS; Silane, Dichlorodimethyl- Chemical Formula: C2H6Cl2Si Molecular Weight: 129.07 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation: (mouse) 0.0003 mg/liter/2 hour (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 158°F, 70°C (NFPA 1984, p. 325M-42) Specific Gravity (H2O=1): 1.1 (NFPA 1984, p. 325M-42) Vapor Pressure (mmHg): 100 at 17.5°C (Weast 1984, p. D-200) Melting Point: -123°F, -86°C (*CHRIS 1978) Vapor Density (AIR=1): 4.45 (NFPA 1984, p. 352M-42) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Decomposes (NFPA 1984, p. 325M-42) Appearance and Odor: Colorless liquid with sharp irritating odor (*CHRIS 1978). ------- CAS Registry Number: 75-78-5 Page 2 of 4 DIMETHYLDICHLOROSILANE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*CHRIS 1978) Skin: Yes (*CHRIS 1978) Ingestion: Yes (*Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): Inhalation irritates mucous membranes. Severe gastrointestinal damage may occur. Vapors cause severe eye and lung injury. Upon short contact, second and third degree burns may occur (*CHRIS 1978). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 16°F (OC) (*Hawley 1977) Flammable Limits: LEL: 3.4% (*Sax 1975) UEL: 9.5% (*Sax 1975) Extinguishing Methods: Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam. Move container from fire area if it can be done without risk. Do not get water inside container. Cool containers that are exposed to fire from outside until well after fire is out. Withdraw immediately in case of rising sound from venting safety device or discoloration of tank due to fire (DOT 1984, Guide 29). Special Fire Fighting Procedures: Avoid contact with skin, eyes, or clothing. Wear acid-vapor respirator, rubber gloves, chemical worker's goggles, other protective and corrosive-resistant equipment as needed (*CHRIS 1978; *Encyc Occupat Health and Safety 1971). Runoff from fire control or dilution water may cause pollution. Isolate for one-half mile in all directions if tank car or truck involved in fire (DOT 1984, Guide 29). Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an enclosed area; reacts with water to produce irritating and toxic gases. Toxic and irritating hydrogen chloride and phosgene may form in fire (CHRIS 1987). Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 29). SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Weiss 1980) ------- CAS Registry Number: 75-78-5 Page 3 of 4 DIMETHYLDICHLOROSILANE SECTION V - REACTIVITY DATA (continued) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Reacts vigorously with water to generate hydrogen chloride ("CHRIS 1978). Hazardous Decomposition or Byproducts: Reacts with water; irritating gas is produced. Hydrogen chloride and phosgene gases may be formed upon heating (CHRIS 1987). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Chemical intermediate for silicone fluids and in ethchlorvynol assays (*SRI; *AOAC 1965). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation and skin contact (see Section III above). Shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled materials; stop leak if you can do so without risk. Use water spray to reduce vapors; however do not get water inside containers. Small spills: absorb with sand or other non-combustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 29). Use effective fume removal device (*AOAC 1965). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Neoprene GOOD/LIMITED** Nitrile POOR/LIMITED** PVC POOR/LIMITED** Viton GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 75-78-5 Page 4 of 4 DIMETHYLDICHLOROSILANE SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 75-78-5 Page 1 of 3 Emergency First Aid Treatment Guide for DIMETHYLDICHLOROSILANE (75-78-5) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless liquid. Odor - Sharp, irritating. Commercial Form - Liquid in steel drums. Use - Manufacture of silicone products. Material to Avoid - Water (except for use in emergency life support). Caution: Flammable liquid. Avoid sources of extreme heat or ignition including sparks or fire. Dimethylchlorosilane will liberate hydrochloric acid upon contact with water. Other Names - Dichlorodimethylsilane, dichlorodimethylsilicon, Inerton AW-DMCS. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W, Ringer's lactate. Signs and Symptoms of Acute Dimethyldichlorosilane Exposure: Signs and symptoms of acute ingestion of dimethyldichlorosilane may be severe and include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. Vomitus generally has a coffee-ground appearance. The potential for circulatory collapse is high following ingestion of dimethyldichlorosilane. ------- EFATG CAS Registry Number: 75-78-5 Page 2 of 3 DIMETHYLDICHL.OROSILANE Acute inhalation exposure may result in sneezing, choking, laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and chest pain. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur. If the eyes have come in contact with dimethyldichlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result Dermatitis (red, inflamed skin), severe bu.rns, pain, and shock generally follow dermal exposure. Emergency Life-Support Procedures: Acute exposure to dimethyldichlorosilane may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to dimethyldichlorosilane. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to dimethyldichlorosilane. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. ------- EFATG CAS Registry Number: 75-78-5 Page 3 of 3 DIMETHYLDICHLOROSILANE 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting or attempt to neutralize! 3. Rinse mouth with large amounts of water. Inform victims not to swallow this water. 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal is of no value. 6. Give the victims water or milk: Children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 7. RUSH to a health care facility. ------- CAS Registry Number: 75-79-6 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - METHYLTRICHLOROSILANE CAS Registry Number: 75-79-6 Synonyms: Methylsilyl Trichloride; Silane, Methyltrichloro-; Silane, Trichloromethyl-; Trichloromethylsilane; Trichloromethylsilicon Chemical Formula: CH3Cl3Si Molecular Weight: 149.48 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.00018 mg/liter/2 hour (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 152°F, 66.5°C (*Clayton and Clayton 1981-82) Specific Gravity (H2O=1): 1.27 at 25°C (*CHRIS 1978) Vapor Pressure (mmHg): Not Found Melting Point: -108°F, -77.8°C (Weast 1983, p. C-515) Vapor Density fAIR=l): 5.17 (*Clayton and Clayton 1981-82) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Not Found Appearance and Odor: Acrid odor, sharp like hydrochloric acid, colorless liquid (*CHRIS 1978). ------- CAS Registry Number: 75-79-6 Page 2 of 3 METHYLTRICHLOROSILANE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Yes (*Sax 1975) Ingestion: Yes (*Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): As with other chlorosilanes, acute exposures may be highly toxic and may cause death or permanent injury after very short exposures to small quantitites. Chronic exposures may be moderately toxic and involve irreversible and reversible changes (*Sax 1975). Skin contact may produce severe burns with pain and risk of secondary infections. Ingestion may produce oral, esophageal, and stomach burns, intensity will vary from mild to very severe, gastrointestinal damage is rare but may occur (*Rumack 1975 to Present). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 45°F (OC); 15°F (CC) (*CHRIS 1978) Flammable Limits: LEL: 7.6% (*NFPA 1978) UEL: 20% (*NFPA 1978) Extinguishing Methods: Dry chemical or carbon dioxide may be used for small fires. Water may be used for large fires if firefighters are protected from violent reaction of methyltrichlorosilane with water. Water may be used to keep containers cool (*NFPA 1978). Special Fire Fighting Procedures: Self-contained breathing apparatus is required as combustion/decomposition yields acid gases/pulmonary irritants.* Corrosion-resistant protective clothing, as well as appropriate foot, hand, arm, head, eye, and face protection are required where contact is possible (*Encyc Occupat Health and Safety 1971). Unusual Fire and Explosion Hazards: Toxic hydrogen chloride and phosgene gases may form in fires. Reacts with water to form hydrochloric acid (CHRIS 1987). Vapor forms flammable mixture with air (*NFPA 1978). May form explosive mixture in air (*Hawley 1977). NFPA Flammability Rating: 3 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*Hawley 1977; 'CHRIS 1978) Stable: ------- CAS Registry Number: 75-79-6 Page 3 of 3 METHYLTRICHLOROSILANE SECTION V - REACTIVITY DATA (continued) Conditions to Avoid: Contact with water or moist air (*NFPA 1978, *Sax 1979). Incompatibility (Materials to Avoid): Reacts with water or steam to form hydrochloric acid ("CHRIS 1978). Hazardous Decomposition or Byproducts: Hydrogen chloride and phosgene formed in fires (*CHRIS 1978). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Monomer for silicone resins (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Spills can be neutralized by flushing with large quantities of water followed by treatment with sodium bicarbonate. Provide adequate protection against generated hydrogen chloride. Do not allow water to get into container since resulting pressure could cause container to rupture (*NFPA 1978). Protect against potentially violent reaction with water (see Section III above). Avoid breathing vapors and contact with skin (see Section III above). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 75-79-6 Page 1 of 3 Emergency First Aid Treatment Guide for METHYLTRICHLOROSILANE (75-79-6) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless liquid. Odor - Sharp, acrid. Commercial Form - Liquid in 55-gallon drums or 1-gallon glass bottles. Use - Manufacture of silicones. Material to Avoid - Water (except for use in emergency life support). Caution: Flammable liquid. Avoid sources of extreme heat or ignition including sparks or fire. Other Names - Methylsilyltrichloride, trichloromethylsilane, trichloromethylsilicon. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W, Ringer's lactate. Signs and Symptoms of Acute Methyltrichlorosilane Exposure: Warning: In the presence of water, methyltrichlorosilane liberates hydrochloric acid, which is extremely corrosive. Caution is advised. Signs and symptoms of acute ingestion of methyltrichlorosilane may include excessive salivation, intense thirst, difficulty in swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. Vomitus generally has a coffee-ground appearance. The potential for circulatory collapse is high following ingestion of methyltrichlorosilane. ------- EFATG CAS Registry Number: 75-79-6 Page 2 of 3 METHYLTRICHLOROSILANE Acute inhalation exposure may result in hoarseness, laryngitis, a feeling of suffocation, dyspnea (shortness of breath), choking, respiratory tract irritation, chest pain, and pulmonary edema. Sneezing, bleeding of the nose and gums, and ulceration of the nasal and oral mucosa may also occur. Renal toxicity has been observed in animals. If the eyes have come in contact with methyltrichlorosilane, then irritation, pain, swelling, corneal erosion, and blindness may result Dermatitis (red, inflamed skin), severe burns, pain, and shock generally follow dermal exposure. Emergency Life-Support Procedures: Acute exposure to methyltrichlorosilane may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to methyltrichlorosilane. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to methyltrichlorosilane. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. r 5. Wash exposed skin areas THOROUGHLY with soap and water. ------- EFATG CAS Registry Number: 75-79-6 Page 3 of 3 METHYLTRICHLOROSILANE 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Rinse mouth with large amounts of water. Inform victims not to swallow this water. 3. DO NOT induce vomiting or attempt to neutralize! 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal is of no value. 6. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 7. RUSH to a health care facility. ------- CAS Registry Number: 75-86-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - ACETONE CYANOHYDRIN CAS Registry Number: 75-86-5 Synonyms: 2-Cyano-2-Propanol; 2-Hydroxy-2-Methylpropionitrile; 2-Hydroxyisobutyronitrile; 2-Methyllactonitrile; 2-Propanone, Cyanohydrin; alpha-Hydroxyisobutyronitrile; Lactonitrile, 2-Methyl-; Propanenitrile, 2-Hydroxy-2-Methyl-; USAF RH-8 Chemical Formula: C4H7NO Molecular Weight: 85.10 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (Guinea Pig) 9 mg/kg (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 180°F, 82°C at 23 mmHg (Weast 1983, p. C-209) Specific Gravity (H2O=1): 0.9267 at 25°C/4°C (*Merck 1976) Vapor Pressure (mmHg): 0.8 at 20°C (*Clayton and Clayton 1981-82) Melting Point: -2.2°F, -19°C (*Merck 1976) Vapor Density (AIR-1): 2.93 (*Clayton and Clayton 1981-82) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Freely soluble in water (*Merck 1976) Appearance and Odon Colorless liquid (*Hawley 1977); distinct strong cyanide odor (*Lefaux 1968) ------- CAS Registry Number: 75-86-5 Page 2 of 4 ACETONE CYANOHYDRIN SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Patty 1963) Skin: Yes (*Patty 1963) Ingestion: Yes (*Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): This material is considered very hazardous and should only be handled under conditions that prevent any inhalation of vapor or skin contact (*Patty 1963). May be slightly irritating to skin and mucous membranes (*Merck 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 165°F, 74°C (CC) (*NFPA 1978) Flammable Limits: LEL: 2.2% (*NFPA 1978) UEL: 12% (*NFPA 1978) Extinguishing Methods: Water may cause frothing if it gets below surface of liquid and turns to steam. Water fog gently applied to surface will cause frothing which will extinguish fire. Use water spray, dry chemical, alcohol foam, or carbon dioxide. Use water to keep fire-exposed containers cool, from a safe distance (*NFPA 1978). Special Fire Fighting Procedures: Wear air-supplied mask with canister approved for use with acrylonitrile in less than 2 percent concentration, rubber or plastic gloves, cover goggles or face mask, rubber boots, slicker suit, safety helmet (*CHRIS 1978). Unusual Fire and Explosion Hazards: Too dangerous to health to expose fire fighters; a few whiffs of vapor could cause death; vapor or liquid could be fatal on penetrating normal protective clothing. Vapor forms explosive mixture with air (*NFPA 1978). On contact with sulfuric acid, it may explode (*Sax 1979). NFPA Flammability Rating: 1 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*NFPA 1978) Stable: ------- CAS Registry Number: 75-86-5 Page 3 of 4 ACETONE CYANOHYDRIN SECTION V (continued) Conditions to Avoid: Vapor forms explosive mixtures with air (*NFPA 1978) Incompatibility (Materials to Avoid): May react violently with water (*NFPA 1978). Contact with sulfuric acid may cause it to explode (*Sax 1979). Hazardous Decomposition or Byproducts: Decomposes when heated to 248°F or at lower temperature under alkaline conditions, emitting highly toxic hydrogen cyanide (*NFPA 1978). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Used in the manufacture of insecticides (*Hawley 1977) and as a chemical intermediate (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). Prevent any inhalation of vapor or skin contact (*Patty 1963). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Nausea, loss of consciousness, convulsions (*Clayton and Clayton 1982); irregular heart beat, headache, vomiting (*Patty 1963). Slightly irritating to the skin (*Merck 1976). Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration (avoid mouth to mouth resuscitation). If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material ------- CAS Registry Number: 75-86-5 Page 4 of 4 ACETONE CYANOHYDRIN SECTION IX (continued) from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation. Avoid contact with contaminated skin (DOT 1984, Guide 55; *Rumack 1975 to Present). ------- CAS Registry Number: 76-02-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY ~ TRICHLOROACETYL CHLORIDE CAS Registry Number: 76-02-8 Synonyms: (NIOSH/RTECS 1985 Synonyms On-Line File) Acetyl Chloride, Trichloro-; Trichloroacetic Acid Chloride; Trichloroacetochloride Chemical Formula: CC13COC1 Molecular Weight: 181.83 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.445 mg/liter (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 244°F, 118°C (Hawley 1981, p. 1040) Specific Gravity (H2O=1): 1.654 at 0°C/4°C (Hawley 1981, p. 1040) Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Decomposes (Weast 1979, p. C-98) Appearance and Odor: Liquid (Hawley 1981, p. 1040) ------- CAS Registry Number: 76-02-8 Page 2 of 4 TRICHLOROACETYL CHLORIDE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIHTLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1040) Skin: Yes (Hawley 1981, p. 1040) Ingestion: Yes (Hawley 1981, p. 1040) Health Hazards (Acute, Delayed, and Chronic): Highly toxic by ingestion and inhalation; strong Irritant to skin and tissues (Hawley 1981, p. 1040). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Material may react violently with water. Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 59). Special Fire Fighting Procedures: Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear positive pressure breathing apparatus and special protective clothing (DOT 1984, Guide 59). Unusual Fire and Explosion Hazards: Material may burn but does not ignite readily. Poisonous if inhaled or swallowed; skin contact poisonous. Contact may cause burns to skin and eyes (DOT 1984, Guide 59). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found ------- CAS Registry Number: 76-02-8 Page 3 of 4 TRICHLOROACETYL CHLORIDE SECTION V (continued) Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Not Found SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid breathing vapors (see Section III above). Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas (DOT 1984, Guide 59). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Contact may cause burns to skin and eyes (DOT 1984, Guide 59). Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 59). ------- CAS Registry Number: 76-02-8 Page 4 of 4 TRICHLOROACETYL CHLORIDE COMMENTS Sources searched but no information found: NIOSH/RTECS 1983 ACGIH 1983 NIOSH/OSHA 1978 Merck 1983 Sax 1984 NFPA 1984 Student 1981 Weiss 1980 CHRIS 1978 Doull 1980 Clayton and Clayton 1981-82 Arena 1979 Gosselin 1984 Encyc Occupat Health and Safety 1983 Buchel 1983 Farm Chemicals Handbook 1984 Hayes 1982 Oilman 1985 ------- CAS Registry Number: 77-47-4 Page 1 of 4 EPA' CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - HEXACHLOROCYCLOPENTADIENE CAS Registry Number: 77-47-4 Synonyms: 1,3-Cyclopentadiene, 1,2,3,4,5,5-Hexachloro-; C 56; Graphlox; HCCPD; Hexachlorocyclopentadien; Hexachloropentadiene; HRS 1655; NCI-C55607; PCL; Perchlorocyclopentadiene Chemical Formula: CSC16 Molecular Weight: 272.77 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.018 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 100 (pounds) RQ: 1 (pounds) (statutory); 100 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 462°F, 239°C at 753 mmHg (*Weast 1984) Specific Gravity (H2O=1): 1.7019 at 25°C/4°C (*Weast 1984) Vapor Pressure (mmHg): 0.080 at 25°C (*Clayton and Clayton 1981-82) Melting Point: 16°F, -9°C (*Weast 1984) Vapor Density (AIR=1): 9.4 (*Clayton and Clayton 1981-82) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 800 ppb (*Clayton and Clayton 1981-82) Appearance and Odor: Yellow-green liquid (*Weast 1984) with a pungent odor (*Hawley 1981) ------- CAS Registry Number: 77-47-4 Page 2 of 4 HEXACHLOROCYCLOPENTADIENE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: TWA 0.1 mg/ms (0.01 ppm) (ACGIH 1986-87, p.20) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Hawley 1981) Skin: Yes (*Hawley 1981) Ingestion: Yes (*Hawley 1981) Health Hazards (Acute, Delayed, and Chronic): This compound is very toxic and may be fatal if inhaled, swallowed, or absorbed through the skin. The probable human lethal dose is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150 Ib. (70 kg) person. Severe exposure induces pulmonary hyperemia and edema, degenerative and necrotic changes in brain, heart and adrenal glands and necrosis of liver and kidney tubules (*DOT 1984; Gosselin 1984, p. 11-169). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Non-flammable (*Hawley 1981) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Use dry chemical, carbon dioxide, water spray or foam for small fires. For large fires, use water spray, fog, or foam. Move hexachlorocyclopentadiene from fire area if this can be done without risk (*DOT 1984). Special Fire Fighting Procedures: Isolate hazard area and deny entry. Wear positive pressure breathing apparatus and special protective clothing. Fight fire from maximum distance. Dike fire control water for later disposal (*DOT 1984). Unusual Fire and Explosion Hazards: Toxic hydrogen chloride, chlorine, and phosgene gases may form in fires. In presence of moisture, will corrode iron and other materials; flammable and explosive hydrogen gas may collect in enclosed space (Weiss 1980, p. 498). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 77-47-4 Page 3 of 4 HEXACHLOROCYCLOPENTADIENE SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Reacts slowly with water to form hydrochloric acid; however, the reaction is not hazardous (Weiss 1980, p. 498). Incompatibility (Materials to Avoid): Will corrode iron and other metals in the presence of moisture (Weiss 1980, p. 498). Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 498) Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Major uses of hexachlorocyclopentadiene include applications as a chemical intermediate for insecticides and flame retardants (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate hazard and deny entry. Stay upwind and keep out of low areas. Ventilate closed spaces before entering. Do not touch spilled material; stop leak if this can be done without risk. Use water spray to reduce vapors. Absorb small spills with sand or other noncombustible absorbent material and place into containers for later disposal. Dike far ahead of large spills for later disposal (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/LIMITED Nitrile POOR/LIMITED Viton GOOD/LIMITED *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 77-47-4 Page 4 of 4 HEXACHLOROCYCLOPENTADIENE * SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Inhalation of mist is highly irritating to mucous membranes, causing tearing, sneezing, and salivation. Eye contact may result in severe irritation. Contact of liquid with the skin may cause blistering and burning (*CHRIS 1978). Headaches and throat irritation have also been reported as a result of exposure to this compound (Clayton and Clayton 1981, p. 3751). Emergency and First Aid Procedures: Move victim to fresh air and call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact with the material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from the skin is of extreme importance. Keep victim quiet and maintain normal body temperature. Since effects may be delayed, keep victim under observation (*DOT 1984). ------- CAS Registry Number: 77-78-1 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - DIMETHYL SULFATE CAS Registry Number: 77-78-1 Synonyms: Dimethyl Monosulfate; Dimethyl Sulphate; DMS; DMS (Methyl Sulfate); Methyl Sulfate; Sulfuric Acid, Dimethyl Ester; Dimethylsulfate Chemical Formula: C2H6O4S Molecular Weight: 126.14 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.28 mg/liter (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory); 100 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: About 370°F, 188°C (with decomposition) (*Merck 1983) Specific Gravity (H2O=1): 1.3283 at 20°C (*Weast 1979) Vapor Pressure (mmHg): 0.1 at room temperature (*IARC 1972-1985); 0.5 at 20°C (NIOSH/OSHA 1978, p. 90) Melting Point: -25.15°F, -31.75°C (*Weast 1979) Vapor Density (AIR=1): 4.35 (*Clayton and Clayton 1981-82) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 2.8 g/100 mL at 18°C (*Merck 1983) Appearance and Odor: It is a colorless oily liquid (*Merck 1983) with a faint, onion-like odor (*NFPA 1978) ------- CAS Registry Number: 77-78-1 Page 2 of 4 DIMETHYL SULFATE SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 5 mg/ms (1 ppm) (NIOSH 1987, p. 110) ACGIH TLV: TWA 0.5 mg/m3 (0.1 ppm) (skin) (ACGIH 1985, p. 17) IDLH: 10 ppm (NIOSH/OSHA 1978, p. 90) Other Limits Recommended: Industrial substance suspect of carcinogenic potential for man (ACGIH 1985, p. 42). Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Yes (*Sax 1975) Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): Acute: extremely toxic vapors and liquid — a few whiffs or contact on skin could be fatal (*NFPA 1978). Also acutely toxic if ingested. Delayed effects which are ultimately fatal may also occur (*Merck 1983). Lethal concentrations as low as 97 ppm/10 min have been reported in humans. DNA inhibition and damage to human somatic cells, and sister chromatid exchange in human fibroblast cells were observed (*NIOSH/RTECS 1985). Delayed appearance of symptoms may permit unnoticed exposure to lethal quantities (Merck 1983, p. 475). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 182°F (CC) (*Hawley 1977) Flammable Limits: Moderate fire potential when exposed to heat or flame (*Sax 1975) LEL: Not Found UEL: Not Found Extinguishing Methods: To extinguish small fires use water, foam, carbon dioxide, and dry chemicals (*Sax 1975). For large fires use water spray, fog, or foam. Move container from fire area if you can do it without risk. Cool containers exposed to flames with water. Fight fire from a maximum distance (DOT 1984, Guide 57). Special Fire Fighting Procedures: Wear positive pressure breathing apparatus and special protective clothing. Dike fire control water for later disposal. Do not scatter material (DOT 1984, Guide 57). Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: 2 ------- CAS Registry Number: 77-78-1 Page 3 of 4 DIMETHYL SULFATE SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*IARC 1972-1985) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Material is normally stable even under fire exposure conditions and is not hazardously reactive with water (*NFPA 1978). It is incompatible with strong oxidizers and strong ammonia solutions (NIOSH/OSHA 1978, p. 90). Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Used as a chemical intermediate for quaternary ammonium salts and for alkylation of phenols and thiols ("'SRI), and as a methylating agent in the manufacture of many organic chemicals (*Merck 1983). Formerly, dimethyl sulfate was used as a war gas. It is also used in the manufacture of dyes, perfumes, for the separation of mineral oils, and for the analysis of auto fluids (*Browning 1965). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) If spilled in a building, the building must be evacuated and the agent decomposed by hosing with water or spraying with 5 percent sodium hydroxide (caustic soda) (*Dreisbach 1977). For large spills, evaporating vapors can be collected in a chamber with a gas cleaning device (*NIOSH/OSHA 1981). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Immediate effects of vapor exposure are eye irritation, cough, swelling of tongue, lips, and larynx, and lungs ------- CAS Registry Number: 77-78-1 Page 4 of 4 DIMETHYL SULFATE SECTION IX (continued) (later). Ingestion or direct contact with mucous membranes causes corrosion. Once absorbed, lung damage and liver and kidney injury will occur (*Dreisbach 1977). Liquid dermal exposure causes blistering, followed by convulsions, delirium, coma, and death in severe cases (*Merck 1983). Emergency and First Aid Procedures: Move victim to fresh air and call emergency medical care. If not breathing, start artificial respiration; if breathing is difficult, give oxygen. If dermal contact occurs, immediately flush with water for 15 minutes. It is very important to quickly remove material from skin. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Since effects may be delayed, keep a close watch on the victim (DOT 1984, Guide 57). ------- CAS Registry Number: 77-81-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - TABUN CAS Registry Number: 77-81-6 Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 127) Phosphoramido- cyanidic Acid, Dimethyl-, Ethyl Ester; Dimethylamidoethoxyphosphoryl Cyanide; Dimethylphosphoramidocyanidic Acid, Ethyl Ester; Ethyl Dimethylamidocyano- phosphate; Ethyl N,N-Dimethylphosphoramidocyanidate; Ethyl N,N-Dimethylamino Cyanophosphate; GA; LE-100; MCE; T-2104; TL 1578 Chemical Formula: C5H11N2O2p Molecular Weight: 162.15 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 skin (mouse) 1 mg/kg (*NIOSH/RTECS 1985) TPQ: 10 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 464°F, 240°C (Merck 1983, p. 1297) Specific Gravity (H2O=1): 1.073 (U.S. Army 1975, p. 3-2) Vapor Pressure (mmHg): 0.07 at 25°C (U.S. Army 1975, p. 3-2) Melting Point: -58°F, -50°C (Merck 1983, p. 1297) Vapor Density (AIR=1): 5.63 (U.S. Army 1975, p. 3-2) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Miscible (Merck 1976, p. 1297). ------- CAS Registry Number: 77-81-6 Page 2 of 4 TABUN SECTION II (continued) Appearance and Odor: Colorless to brown liquid; faint fruity odor (U.S. Army 1975, p.3-2) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (U.S. Army 1975, p. 3-2) Skin: Yes (U.S. Army 1975, p. 3-2) Ingestion: Yes (U.S. Army 1975, p. 3-2) Health Hazards (Acute, Delayed, and Chronic): This material is toxic by inhalation and by absorption through skin and eyes. The lethal dose for humans may be as low as 0.01 mg/kg (Merck 1983, p. 1297). Tabun is a nerve agent; it acts as a cholinesterase inhibitor. The median lethal dosage (respiratory) is 400 mg-minute/m3 for humans; the median incapacitating dosage is 300 mg-minute/m3. Respiratory lethal dosages kill in 1 to 10 minutes; liquid in the eye kills nearly as rapidly. Skin absorption great enough to cause death may occur in 1 to 2 minutes, but may be delayed for 1 to 2 hours (U.S. Army 1975, p. 3-3). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 172°F (Sax 1984, p. 1335) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific - Poison A, Liquid) Extinguish with alcohol foam, carbon dioxide, or dry chemical (Student 1981, p. 56) Special Fire Fighting Procedures: Complete protection required; have available decontaminants (bleach, alkali) and atropine (U.S. Army 1975, p. 3-2). Bleaching powder (chlorinated line) destroys Tabun but gives rise to cyanogen chloride (Merck 1983, p. 1297). Unusual Fire and Explosion Hazards: Extremely poisonous (Merck 1983, p. 1297). (Non-Specific — Poison A, Liquid) Keep away from sparks, flames, and sources of ignition. Keep out of water sources and sewers (Student 1981, p. 56). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 77-81-6 Page 3 of 4 TABUN SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (U.S. Army 1975, p. 3-3) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Avoid water and acids (U.S. Army 1975, p. 3-2). Can react with oxidizing materials (Sax 1984, p. 1335). Hazardous Decomposition or Byproducts: Hydrolysis forms hydrogen cyanide (U.S. Army 1975, p. 3-2). When heated to decomposition, it emits very toxic fumes of oxides of phosphorus and nitrogen (Sax 1984, p. 1335). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION This material is a chemical warfare agent (Merck 1983, p. 1297). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Poison A, Liquid) When handling, avoid breathing vapors, keep upwind, avoid bodily contact with the material, and upon skin contact wash with soap and water (Student 1981, p. 56). Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 77-81-6 Page 4 of 4 TABUN SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Nerve agent symptoms include difficulty in breathing, drooling, nausea, vomiting, cramps, involuntary defecation and urination, twitching, jerking, staggering, headache, confusion, drowsiness, coma, and convulsion. Inhalation causes dimness of vision and pinpointing of the pupils (U.S. Army 1975, p. 3-2). Emergency and First Aid Procedures: The toxic effects of tabun are similar to parathion (Sax 1984, p. 1335). First aid for parathion is as follows: move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 78-00-2 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - TETRAETHYLLEAD CAS Registry Number: 78-00-2 Synonyms: Lead, Tetraethyl-; NCI-C54988; Plumbane, Tetraethyl-; TEL; Tetraethyl Lead, Liquid; Tetraethyl Lead; Tetraethylplumbane Chemical Formula: C8H20Pb Molecular Weight: 323.45 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 12.3 mg/kg TPQ: 100 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): In Lead Compounds category SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: About 392°F, 200°C (*Merck 1983); decomposes between 110 and 200°C (Verschueren 1983, p. 1085) Specific Gravity (H2O=1): 1.653 at 20°C (*Merck 1983) Vapor Pressure (mmHg): 0.2 at 20°C (*IARC 1972-1985) Melting Point: -202°F, -130°C (*IARC 1972-1985) Vapor Density (AIR=1): 8.6 (NFPA 1984, p. 325M-86) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (*IARC 1972-1985) Appearance and Odor: Colorless liquid with a pleasant odor (Hawley 1981, p. 1006) ------- CAS Registry Number: 78-00-2 • Page 2 of 3 TETRAETHYLLEAD SECTION III - HEALTH HAZARD DATA OSHA PEL: 0.075 mg (lead)/m3 (NIOSH 1987, p.220) ACGIH TLV: 0.100 mg (lead)/m3 (skin) (ACGIH 1986-87, p.30) IDLH: 40 mg (lead)/m3 (NIOSH 1987, p. 220) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Venugopal 1978) Skin: Yes (*Venugopal 1978) Ingestion: Yes (*Venugopal 1978) Health Hazards (Acute, Delayed, and Chronic): Extremely poisonous; may be fatal if inhaled, swallowed, or absorbed from the skin. Contact may cause burns to skin and eyes (*DOT 1984). Most symptoms-of poisoning are due to the effects of tetraethyllead on the nervous system (*Gilman 1980). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 200°F (no method given) (NFPA 1984, p. 325M-86) Flammable Limits: LEL: 1.8 percent by volume (NFPA 1984, p. 325M-86) UEL: Not Found Extinguishing Methods: Water spray may be used because the material can be cooled below its flash point (*NFPA 1978). Special Fire Fighting Procedures: Fire fighting should be done from an explosive-resistant location. Use water from unmanned monitors and hose-holders to keep fire-exposed containers cool. When stopping leak, use water spray to protect firefighters (*NFPA 1978). Runoff from fire control or dilution water may cause pollution (*DOT 1984). Unusual Fire and Explosion Hazards: May explode in fires (*CHRIS 1978). NFPA Flammability Rating: 2 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*IARC 1972-1985) Stable: Conditions to Avoid: Decomposes slowly at room temperature and more rapidly at elevated temperatures (*IARC 1972-1985). Incompatibility (Materials to Avoid): Not Found ------- CAS Registry Number: 78-00-2. Page 3 of 3 TETRAETHYLLEAD SECTION V (continued) Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Virtually all of the tetraethyllead produced in the USA is used as an antiknock additive for gasolines (*IARC 1972-1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Tetraethyllead is hazardous, but areas may be entered with extreme care. No skin surface should be exposed. Use water spray to disperse vapors (*NFPA 1978). Outdoors, stay upwind and keep out of low areas. Isolate hazard area (*DOT 1984). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 78-00-2 Page 1 of 3 Emergency First Aid Treatment Guide for TETRAETHYLLEAD (78-00-2) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless, oily liquid. Odor - Pleasant, sweet odor. Commercial Form - 98% pure liquid dyed red or other distinctive color. Uses - Aviation gasoline, antiknock agent, ethylating agent. Materials to Avoid - Oxidizers. Caution: Flammable liquid. When burned, toxic fumes of lead oxide will be emitted. Avoid sources of extreme heat or ignition including sparks or fire. Other Names - Lead tetraethyl, tetraethylplumbane, TEL. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, phenytoin, phenobarbitol, mannitol, dexamethasone. Signs and Symptoms of Acute Tetraethyllead Exposure: Warning: Effects may be delayed for hours to days. Caution is advised. Signs and symptoms of acute exposure to tetraethyllead may be severe and include anxiety, irritability, insomnia, violent/frightening dreams, headache, disorientation, hyperexcitability, delusions, and hallucinations. Muscular weakness, ataxia, tremors, convulsions, cerebral edema, and coma may occur. A metallic taste may be noted. Sneezing, bronchitis, and pneumonia may be observed. Bradycardia (slow heart rate), hypotension (low blood pressure), hypothermia, and pallor may also occur. Gastrointestinal symptoms include vomiting and diarrhea. Tetraethyllead may irritate moist skin, eyes, and mucous membranes. ------- EFATG CAS Registry Number: 78-00-2 Page 2 of 3 TETRAETHYLLEAD Emergency Life-Support Procedures: Acute exposure to tetraethyllead may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to tetraethyllead. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to tetraethyllead. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. ------- EFATG CAS Registry Number: 78-00-2 Page 3 of 3 TETRAETHYLLEAD Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. RUSH to a health care facility. ------- CAS Registry Number: 78-34-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - DIOXATHION CAS Registry Number: 78-34-2 Synonyms: l,4-Dioxan-2,3-diyl Bis(O,O-Diethyl Phosphorothiolothionate); l,4-Dioxan-2,3-Diyl O,O,O',0'-Tetraethyl Di(Phosphorodithioate); 1,4-Dioxane- 2,3-S,S'-Bis(O,O-Diethyl Dithiophosphate); 2,3-Bis(Diethoxyphosphinothioylthio)- 1,4-Dioxane; 2,3-Dioxane S,S-Bis(O,O-Diethylphosphorodithioate); 2,3- Dioxanedithiol S,S-Bis(O,O-Diethyl Phosphorodithioate); AC 528; Bercotox; Delnatex; Delnav; Dioxation; Dioxothion; ENT 22,897; Hercules 528; Hercules AC528; Kavadel; Navadel; NCI-C00395; p-Dioxane-2,3-Dithiol, S,S-Diester with O,O-Diethyl Phosphorodithioate; p-Dioxane-2,3-diyl Ethyl Phosphorodithioate; Phosphorodithioic Acid, S,SM,4-Dioxane-2,3-diyl O,O,O',O'-Tetraethyl Ester; Phosphorodithioic Acid, S,S'-p-Dioxane-2,3-diyl O,O,O',O'-Tetraethyl Ester; Ruphos Chemical Formula: C12H26O6P2S4 Molecular Weight: 456.54 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.34 mg/liter/1 hour (*NIOSH/RTECS 1985). TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: Not Found Specific Gravity (H2O=1): 1.257 at 26°C/4°C (*Merck 1976) Vapor Pressure (mmHg): Not Found Melting Point: -4°F, -20°C (*Merck 1983) Vapor Density (AIR=»1): Not Found ------- CAS Registry Number: 78-34-2 Page 2 of 4 DIOXATHION SECTION II (continued) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Practically insoluble (*Merck 1983) Appearance and Odor: Tan liquid (*Merck 1983). (Technical) Brown liquid (*Martin 1974). SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: 0.2 mg/m3 (skin) (ACGIH 1985, p. 17) IDLH: Not Found Other Limits Recommended: ADI 0.0015 mg/kg (*Hayes 1975). Routes of Entry: Inhalation: Yes (*Hawley 1977) Skin: Yes (Farm Chemicals Handbook 1984, p. C-82) Ingestion: Yes (*Hawley 1977) Health Hazards (Acute, Delayed, and Chronic): Very toxic. Probable oral lethal dose for humans is 50-500 mg/kg or between 1 teaspoonful and 1 oz. for a 70 kg (150 Ib.) person (*Gosselin 1976). It is a cholinesterase inhibitor (*Hawley 1977). Death is primarily due to respiratory arrest arising from failure of the respiratory center, paralysis of respiratory muscles, intense bronchoconstriction, or all three (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). ------- CAS Registry Number: 78-34-2 Page 3 of 4 DIOXATHION SECTION IV (continued) Unusual Fire and Explosion Hazards: Shock can shatter container, releasing contents (*Sax 1975). (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Container may explode in heat of fire. Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stabler Yes (*ACGIH 1979) Conditions to Avoid: Avoid alkali materials and heat. It is unstable to iron or tin surfaces and when mixed with certain carriers (*Martin 1974). Incompatibility (Materials to Avoid): Avoid alkali materials (*Martin 1974) Hazardous Decomposition or Byproducts: When heated to decomposition, it emits highly toxic fumes of oxides of nitrogen, phosphorus, and sulfur (*Sax 1975). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Dioxathion is used for control of insects and mites on grapes, citrus, walnuts, ornamentals, apples, pears, and quince. Also used as a spray or dip for the control of ticks, lice, hornfly, and sheep ked on cattle, goats, sheep, and hogs (Farm Chemicals Handbook 1984, p. C-82). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific - Organophosphorus Pesticide, Liquid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). ------- CAS Registry Number: 78-34-2 Page 4 of 4 DIOXATHION SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 78-34-2 Page 1 of 3 Emergency First Aid Treatment Guide for DIOXATHION (78-34-2) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Tan liquid. Commercial Forms - Brown emulsifiable concentrate or wettable powder. Use - Pesticide. Other Names - Delnatex; Delnav; Deltic; l,4-dioxan-2,3-diyl bis(O,O-diethyl phosphorothiolothionate); Dioxation; Kavadel; Navadel. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Dioxathion Exposure: Note: Dioxathion is a cholinesterase inhibitor. Acute exposure to dioxathion may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) may occur although hypertension (high blood pressure) is not uncommon. Chest pain may be noted. Respiratory symptoms include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur. ------- EFATG CAS Registry Number: 78-34-2 Page 2 of 3 DIOXATHION Emergency Life-Support Procedures: Acute exposure to dioxathion may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to dioxathion. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to dioxathion. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin area three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 78-34-2 Page 3 of 3 DIOXATHION Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of dioxathion is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of dioxathion may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 78-53-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - AMITON CAS Registry Number: 78-53-5 Synonyms: (NIOSH/RTECS SYNONYMS 1983, Volume 3, p. 150) Phosphorothioic Acid, S-(2-(Diethylamino)Ethyl) O,0-Diethyl Ester; Chipman 6200; Citram; S-(Diethylaminoethyl) O,O-Diethyl Phosphorothioate; Diethyl S-2-Diethylaminoethyl Phosphorothioate; (2-Diethylamino)Ethylphosphorothioic Acid O,O-Diethyl Ester; O,O-Diethyl S-2-Diethylaminoethyl Phosphorothioate; O,O-Diethyl S-Diethylaminoethyl Phosphorothiolate; O,O-Diethyl S-2-Diethyl- aminoethyl Phosphorothiolate; O,O-Diethyl S-(beta-Diethylamino)Ethyl Phosphorothiolate; O,O-Diethyl S-(2-Diethylaminoethyl) Thiophosphate; DSDP; ENT 24,980-X; Inferno; Metramac; Metramak; R-5,158; Rhodia-6200; Tetram Chemical Formula: C10H24NO3PS Molecular Weight: 269.38 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 3.3 mg/kg (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 230°F, 110°C at 0.2 mm (Sax 1984, p. 1008) Specific Gravity (H2O=»1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=»1): Not Found Evaporation Rate (Butyl acetate=l): Not Found ------- CAS Registry Number: 78-53-5 Page 2 of 4 AMITON SECTION II (continued) Solubility in Water: Not Found Appearance and Odor: Liquid (Merck 1983, p. 73) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1009) Skin: Not Found Ingestion: Yes (Sax 1984, p. 1009) Health Hazards (Acute, Delayed, and Chronic): This material is highly toxic orally. It is a cholinesterase inhibitor (Sax 1984, p. 1009). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition, can emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur (Sax 1984, p. 1009). (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Container may explode in heat of fire. Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution (DOT 1984, Guide 55). ------- CAS Registry Number: 78-53-5 Page 3 of 4 AMITON SECTION IV (continued) NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Extreme heat (Sax 1984, p. 1009) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Very toxic nitrogen oxides, phosphorus oxides, and sulfur oxides when heated to decomposition (Sax 1984, p. 1009). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION This material is used as an acaricide and insecticide (Farm Chemicals Handbook 1984, p. C222). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 78-53-5 Page 4 of 4 AMITON SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: The toxic effects are similar to parathion (Sax 1984, p. 1009). Symptoms of parathion poisoning include anorexia, nausea, vomiting, diarrhea, excessive salivation, pupillary constriction, bronchoconstriction, muscle twitching, convulsions, coma, respiratory failure. Effects are cumulative (Sax 1984, p. 2119). Emergency and First Aid Procedures: Effects are similar to those of parathion (Sax 1984, p. 1009). First aid procedures for parathion are as follows: move victim to fresh air; call emergency medical care. If not breathing, perform artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 78-71-7 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - OXETANE, 3,3-BIS(CHLOROMETHYL)- CAS Registry Number: 78-71-7 Synonyms: (NIOSH/RTECS 1985 Synonyms On-Line File) 3,3-Bis (Chloromethyl)Oxetane; Penton; 3,3-bis(Chloromethyl)-1 -Oxacyclobutane Chemical Formula: C5H8C120 Molecular Weight: 155 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC60 inhalation (mouse) 0.2 mg/liter/2 hours (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 217°F, 103°C at 30 mmHg (Beilstein 1974, Volume 17/1, p. 68) Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 66°F, 19°C (Beilstein 1974, Volume 17/1, p. 68) Vapor Density (AIR=«1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Not Found Appearance and Odor: Not Found ------- CAS Registry Number: 78-71-7 Page 2 of 3 OXETANE, 3,3-BIS(CHLOROMETHYL) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Not Found Health Hazards (Acute, Delayed, and Chronic): Not Found Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found ------- CAS Registry Number: 78-71-7 Page 3 of 3 OXETANE, 3,3-BIS(CHLOROMETHYL) SECTION VI - USE INFORMATION Penton is the trademark for a thermoplastic resin derived from 3,3-bis(chloromethyl)oxetane. Penton is a linear polymer used for solid and lined valves, pumps, pipe and fittings, and a monofilament for filter supports and column packing (Hawley 1981, p. 785). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Not Found SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Not Found Emergency and First Aid Procedures: Not Found COMMENTS: Sources searched but no information found: Weast 1979 Merck 1983 Sax 1984 DOT 1984 NFPA 1984 Student 1981 Weiss 1980 Doull 1980 Clayton and Clayton 1981-82 Encyc Occupat Health and Safety 1983 CHRIS 1978 Hayes 1982 ------- CAS Registry Number: 78-82-0 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - ISOBUTYRONITRILE CAS Registry Number: 78-82-0 Synonyms: 2-Methylpropanenitrile; 1-Cyano-l-Methylethane; 2-Cyanoprbpane; 2-Methylpropane Nitrile; 2-Methylpropionitrile; Dimethylacetonitrile; Isopropyl Cyanide; Isopropyl Nitrile; Isopropylcyanide; Propanenitrile, 2-Methyl-; Propanoic Acid, 2-Methyl-, Nitrile Chemical Formula: C4H7N Molecular Weight: 69.1 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mouse) 25 mg/kg (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 219°F, 103.8°C (*Weast 1979) Specific Gravity (H2O=1): 0.7608 at 30°C/4°C (*Weast 1979); 0.733 at 20°C (*Hawley 1977) Vapor Pressure (mmHg): Not Found Melting Point: -96.7°F, -71.5°C (*Weast 1979) Vapor Density (AIR=1): 2.38 (*NFPA 1978) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Slightly (*Weast 1979) Appearance and Odor: Colorless liquid (*Hawley 1977) ------- CAS Registry Number: 78-82-0 Page 2 of 4 ISOBUTYRONITRILE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Occupational exposure to nitriles — recommended standard in air: TWA 22 mg/ms (*NIOSH/RTECS 1985). Routes of Entry: Inhalation: Yes (Hawley 1981, p. 577) Skin: Yes (Hawley 1981, p. 577) Ingestion: Yes (Hawley 1981, p. 577) Health Hazards (Acute, Delayed, and Chronic): Poisonous; may be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes (DOT 1984, Guide 28). (Non-Specific - Nitriles) Primarily, they are skin and eye irritants. Large doses cause collapse and stop breathing (Clayton and Clayton 1981-82, p. 4846). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 47°F, 8°C (*NFPA 1978) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Extinguish with dry chemical, carbon dioxide, water spray, foam, or fog (DOT 1984, Guide 28). Special Fire Fighting Procedures: Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear positive pressure breathing apparatus and special protective clothing. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire. Move container from fire area if you can do so without risk. Dike fire control water for later disposal; do not scatter the material. Spray cooling water on containers that are exposed to flames until well after fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire (DOT 1984, Guide 28). Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an enclosed area (Weiss 1980, p. 531). Toxic oxides of nitrogen are produced during combustion (Student 1981, p. 297). It is a flammable/combustible material and may be ignited by heat, sparks, or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 28). NFPA Flammability Rating: 3 ------- CAS Registry Number: 78-82-0 Page 3 of 4 ISOBUTYRONITRILE SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Weiss 1980, p. 531) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits toxic fumes of oxides of nitrogen (Sax 1984, p. 1639). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 531) Conditions to Avoid: Not Found SECTION VI - USE INFORMATION It is used in organic synthesis (*Patty 1963); as an intermediate for insecticides (Hawley 1981, p. 577); and as a gasoline additive (Clayton and Clayton 1981-82, p. 4873). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to control flow as necessary. Attempt to stop leak if this can be done without hazard. Use water spray to disperse vapors and dilute standing pools of liquid. Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water (Student, 1981, p. 297). Wear positive pressure breathing apparatus and special protective clothing. Shut off ignition sources; no flares, smoking, or flames in hazard area. Do not touch spilled material. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 19^4, Guide 28). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 78-82-0 Page 4 of 4 ISOBUTYRONITRILE SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED** PE POOR/LIMITED** PVC POOR/LIMITED** Viton GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 78-82-0 Page 1 of 3 Emergency First Aid Treatment Guide for ISOBUTYRONITRILE (78-82-0) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Caution: Isobutyronitrile toxicity can occur via ingestion, dermal/eye contact, or inhalation; death may occur within minutes. IMMEDIATELY begin administering 100% oxygen and RUSH victims to a health care facility! Substance Characteristics: Pure Form - Colorless liquid. Commercial Form - Liquid in tank cars. Uses - Chemical intermediate, pesticide intermediate, gasoline additive. Caution: Flammable liquid. Avoid sources of extreme heat or ignition including sparks or fire. Isobutyronitrile will liberate toxic nitrogen oxide fumes when heated to decomposition. Other Names - 1-Cyano-l-methylethane, isopropyl cyanide, isopropyl nitrile, 2-methylpropane nitrile. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium bicarbonate, diazepam, phenytoin. Signs and Symptoms of Acute Isobutyronitrile Exposure: Warning: Heart palpitation may occur within minutes after exposure. High doses can stop breathing. Vital signs should be monitored closely. Caution is advised. ------- EFATG CAS Registry Number: 78-82-0 Page 2 of 3 ISOBUTYRONITRILE Signs and symptoms of acute exposure to isobutyronitrile may include hypertension (high blood pressure) and tachycardia (rapid heart rate), followed by hypotension (low blood pressure) and bradycardia (slow heart rate). Cherry-red (and potentially bloody) mucous membranes, cardiac arrhythmias, and other cardiac abnormalities are common. Cyanosis (blue tint to skin and mucous membranes) may also be found. Tachypnea (rapid respiratory rate) may be followed by respiratory depression. Lung hemorrhage and pulmonary edema may occur. Headache, vertigo (dizziness), agitation, giddiness, salivation, nausea, and vomiting may be followed by combative behavior, convulsions, and coma. Isobutyronitrile is irritating to the skin and mucous membranes. Lacrimation (tearing) and a burning sensation of the mouth and throat are common. Emergency Life-Support Procedures: Acute exposure to isobutyronitrile may require decontamination and life support for the victims. All exposed persons should be transported to a health care facility as quickly as possible. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to isobutyronitrile. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with isobutyronitrile- contaminated persons or their gastric contents may result in self- poisoning. 3. RUSH to a health care facility! 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to isobutyronitrile. ------- EFATG CAS Registry Number: 78-82-0 Page 3 of 3 ISOBUTYRONITRILE 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with isobutyronitrile- contaminated persons or their gastric contents may result in self- poisoning. 3. RUSH to a health care facility! 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Remove contaminated clothing as soon as possible. 6. Wash exposed skin areas twice with soap and water. 7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with isobutyronitrile- contaminated persons or their gastric contents may result in self- poisoning. 2. RUSH to a health care facility! 3. DO NOT induce vomiting or attempt to neutralize! 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal is of no value. ------- CAS Registry Number: 78-94-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - METHYL VINYL KETONE CAS Registry Number: 78-94-4 Synonyms: l-Buten-3-one; 2-Butenone; 3-Buten-2-one; 3-Butene-2-one; Acetone, Methylene-; Acetyl Ethylene; Butenone; Delta(3)-2-Butenone; Gamma-Oxo- Alpha-Butylene; Ketone, Methyl Vinyl; Methylene Acetone; Methylvinyl Ketone; Vinyl Methyl Ketone Chemical Formula: C4H6O Molecular Weight: 70.09 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.007 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 10 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 179°F, 81.4°C (*Merck 1983) Specific Gravity (H2O=1): 0.8636 at 20°C/4°C; 0.8407 at 25°C/4°C (*Merck 1983) Vapor Pressure (mmHg): Not Found Melting Point: 20°F, -7°C (*CHRIS 1978) Vapor Density (AIR=«1): 2.41 (*Sax 1979) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (*Merck 1983) ------- CAS Registry Number: 78-94-4 Page 2 of 4 METHYL VINYL KETONE SECTION II (continued) Appearance and Odor: Colorless liquid (*Hawley 1981) with pungent odor (*Merck 1983) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Similar to other ketones) (*Rumack 1975 to Present) Skin: Yes (*Merck 1983) Ingestion: Yes (*DOT 1984) Health Hazards (Acute, Delayed, and Chronic): This material is readily absorbed through the skin, causing general poisoning (*Merck 1983) similar to other ketones; inhalation has central nervous system depressant effects (*Rumack 1975 to Present). It is irritating to mucous membranes and respiratory tract (*Merck 1983) and to the skin; it is a lachrymator and can cause eye injury (*Grant 1974). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 20°F, -6.6°C (CC) (*Hawley 1981); 30°F, -U°C (OC) (*CHRIS 1978) Flammable Limits: LEL: 2.1% (*NFPA 1978) UEL: 15.6% (*NFPA 1978) Extinguishing Methods: Use dry chemical, alcohol foam, 'or carbon dioxide. Water spray may be ineffective as an extinguishing agent (*NFPA 1978). Small fires: dry chemical, carbon dioxide, and foam. Large fires: fog or foam. Move container from fire area if you can do so without risk. Dike fire control water for later disposal; do not scatter the material. Spray cooling water on containers that are exposed to flames until well after fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire (DOT 1984, Guide 28). Special Fire Fighting Procedures: Use water to keep fire-exposed containers cool (*NFPA 1978). Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear positive pressure breathing apparatus and special protective clothing. Isolate for ------- CAS Registry Number: 78-94-4 Page 3 of 4 METHYL VINYL KETONE SECTION IV (continued) 1/2 mile in all directions if tank car or truck is involved in fire (DOT 1984, Guide 28). Unusual Fire and Explosion Hazards: Vapors form flammable mixtures with air, and may travel a considerable distance to a source of ignition and flash back. Polymerization may take place in containers, possibly with violent rupture of containers (*NFPA 1978). Upon exposure to heat or flame, it emits toxic and irritating fumes (*Sax 1979). Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors, or in sewers (DOT 1984, Guide 28). NFPA Flammability Rating: 3 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*NFPA 1978) Stable: Conditions to Avoid: Polymerizes on standing (*Merck 1983) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Yes (*NFPA 1978) May Not Occur: Conditions to Avoid: Heat or sunlight (*NFPA 1978) SECTION VI - USE INFORMATION This material is used as an alkylating agent, a starting material for plastics, and an intermediate in the synthesis of steroids and Vitamin A (*Merck 1983). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid breathing vapors (see Section III above). Isolate area. Stay upwind; keep out of low areas. Shut off ignition sources; no flares, smoking, or flames in hazard area. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Absorb small spills with sand or other noncombustible absorbent material and place into containers for later disposal. For large spills, dike far ahead for later disposal (*DOT 1984). ------- CAS Registry Number: 78-94-4 Page 4 of 4 METHYL VINYL KETONE SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) CPE POOR/LIMITED** Neoprene POOR/LIMITED** PE POOR/LIMITED** PVC POOR/LIMITED** Viton POOR/LIMITED** Viton/Neoprene POOR/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Liquid or high concentration of vapors causes blistering of the skin (*NFPA 1978). Similar to other ketones; can cause sore throat, sneezing, coughing, and salivation. Inhalation may cause nausea and vomiting; inhalation of high concentrations can cause headache, dizziness, fainting, tremor, uncoordination, lowered body temperature, depressed respiratory and heart rate, gasping, coma, and death. Direct aspiration of liquid into lungs can cause chemical pneumonia. (*Rumack 1975 to Present) Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (*DOT 1984). ------- CAS Registry Number: 78-97-7 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - LACTONITRILE CAS Registry Number: 78-97-7 Synonyms: 2-Hydroxypropanenitrile; 2-Hydroxypropionitrile; Acetaldehyde Cyanohydrin; Acetocyanohydrin; alpha-Hydroxypropionitrile; Ethylidene Cyanohydrin; Propanenitrile, 2-Hydroxy-; Propanoic Acid, 2-Hydroxy-, Nitrile Chemical Formula: C3H5NO Molecular Weight: 71 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 skin (rabbit) 20 mg/kg TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 360-363°F, 182-184°C; slight decomposition (Weast 1979, p. C-456) Specific Gravity (H2O=1): 0.9877 at 20°C/4°C (*Weast 1979) Vapor Pressure (mmHg): 10 at 74°C (*Patty 1963) Melting Point: -40°F, -40°C (*Weast 1979) Vapor Density (AIR-1): 2.45 (*NFPA 1978) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble in all proportions (*Weast 1979) Appearance and Odor: Straw colored liquid (*Patty 1963) ------- CAS Registry Number: 78-97-7 Page 2 of 3 LACTONITRILE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and Safety 1971) Skin: Yes (*Encyc Occupat Health and Safety 1971) Ingestion: Yes (*Encyc Occupat Health and Safety 1971) Health Hazards (Acute, Delayed, and Chronic): Extremely toxic by oral, skin, or eye contact (*Patty 1963) Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 170°F (TCC) (Sax 1984, p. 1683) Flammable Limits: Moderate when exposed to heat or flame (*Encyc Occupat Health and Safety 1971) LEL: Not Found UEL: Not Found Extinguishing Methods: Foam, carbon dioxide, dry chemical (Sax 1984, p. 1683). Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Cyanide fumes released when heated to decomposition (*Encyc Occupat Health and Safety 1971). NFPA Flammability Rating: 2 SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Alkali (*Hawley 1977); oxidizing material (Sax 1984, p. 1683). Hazardous Decomposition or Byproducts: Cyanide fumes when heated to decomposition (*Encyc Occupat Health and Safety 1971); hydrocyanic acid in presence of alkali (*Hawley 1977). ------- CAS Registry Number: 78-97-7 Page 3 of 3 LACTONITRILE SECTION V (continued) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Solvent — intermediate in production of ethyl lactate and lactic acid (*Hawley 1977). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not breathe vapors or touch spilled material (see Section III above). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED** PE POOR/LIMITED** PVC POOR/LIMITED** Viton GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 78-97-7 Page 1 of 3 Emergency First Aid Treatment Guide for LACTONITRILE (78-97-7) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Caution: Lactonitrile toxicity can occur via ingestion, dermal/eye contact, or ingestion; death may occur within minutes. IMMEDIATELY begin administering 100% oxygen and rush victims to a health care facility. Substance Characteristics: Pure Form - Straw-colored liquid. Commercial Form - 95 to 97% pure liquid in carboys. Uses - Chemical intermediate, solvent. Materials to Avoid - Alkali, oxidizers. Caution: Toxic hydrogen cyanide gas may be released upon contact with alkali or when heated to decomposition. Other Names - Acetaldehyde cyanohydrin, ethylidene cyanohydrin, 2-hydroxypropanenitrile, 2-hydroxypropionitrile. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May be Required: Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium bicarbonate, diazepam, phenytoin. Signs and Symptoms of Acute Lactonitrile Exposure: Warning: Heart palpitations may occur within minutes after exposure. Caution is advised. Vital signs should be monitored closely. Symptoms may be delayed. Signs and symptoms of acute exposure to lactonitrile may include hypertension (high blood pressure) and tachycardia (rapid heart rate), followed by hypotension (low blood pressure) and bradycardia (slow heart rate). Cherry-red mucous membranes and blood, cardiac arrhythmias, and other cardiac abnormalities are common."7 Cyanosis (blue tint to the skin and mucous ------- EFATG CAS Registry Number: 78-97-7 Page 2 of 3 LACTONITRILE membranes) may be present following exposure to lactonitrile. Salivation, nausea, and vomiting may also occur. Tachypnea (rapid respiratory rate) may be followed by respiratory depression. Lung hemorrhage and pulmonary edema may occur. Headache, vertigo (dizziness), agitation, and giddiness may be followed by combative behavior, convulsions, paralysis, protruding eyeballs, dilated and unreactive pupils, and coma. Lactonitrile is irritating to the skin and mucous membranes. Lacrimation (tearing) and a burning sensation of the mouth and throat are common. Emergency Life-Support Procedures: Acute exposure to lactonitrile may require decontamination and life support for the victims. All exposed persons should be transported to a health care facility as quickly as possible. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to lactonitrile. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with lactonitrile-contaminated persons or their gastric contents may result in self-poisoning. 3. RUSH to a health care facility! 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to lactonitriie. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. ------- EFATG CAS Registry Number: 78-97-7 Page 3 of 3 LACTONITRILE Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with lactonitrile-contaminated persons or their gastric contents may result in self-poisoning. 3. RUSH to a health care facility! 4. Remove contaminated clothing as soon as possible. 5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 6. Wash exposed skin areas twice with soap and water. 7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with lactonitrile-contaminated persons or their gastric contents may result in self-poisoning. 2. RUSH to a health care facility! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. DO NOT induce vomiting. Ipecac is not recommended for ingestion of lactonitrile. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. ------- CAS Registry Number: 79-06-1 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ACRYLAMIDE CAS Registry Number: 79-06-1 Synonyms: 2-Propenamide; Acrylic Amide; Ethylene Carboxamide; Propenamide; Propenoic Acid, Amide Chemical Formula: CSH5NO Molecular Weight: 71.08 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: Chemical does not meet the toxicity criteria but because of its high production volume and recognized toxicity it is considered a chemical of concern. TPQ: 1,000/10,000 (pounds) RQ: 5000 (pounds) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: 189°F, 87°C at 2 mmHg (*Merck 1976) Specific Gravity (H2O=1): 1.122 at 30°C/4°C (*Merck 1976) Vapor Pressure (mmHg): 0.007 at 20°C (*ACGIH 1980) Melting Point: 184°F, 84.5°C (*Merck 1976) Vapor Density (AIR=1): 2.45 (*Sax 1975) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 215.5 g/100 mL water at 30°C (*Merck 1976) Appearance and Odor: Odorless (*Grant 1974) white, crystalline solid (*Sax 1975). ------- CAS Registry Number: 79-06-1 Page 2 of 4 ACRYLAMIDE SECTION III - HEALTH HAZARD DATA OSHA PEL: Air: TWA 0.3 mg/ms (skin) (OSHA 1984, p. 660) ACGIH TLV: TWA 0.3 mg/ms; STEL 0.6 mg/ms (skin) (*ACGIH 1981) IDLH: Not Found Other Limits Recommended: NIOSH: 0.3 mg/ms 10 hr TWA (NIOSH 1987, p.46). It is recommended that no more than 0.05 mg/kg/day be absorbed by workers (*ACGIH 1980). Suspected of carcinogenic potential in humans; notice of intent to change to 0.03 mg/ms for 1985-86 (ACGIH 1985, p. 42). Routes of Entry: Inhalation: Yes (NIOSH/OSHA 1978, p. 43) Skin: Yes (*Hamilton 1974) Ingestion: Yes (NIOSH/OSHA 1978, p. 43) Health Hazards (Acute, Delayed, and Chronic): Classified as very toxic; probable oral lethal human dose is between 50 and 500 mg/kg or between. 1 teaspoon and 1 ounce for a 150 Ib. person (Gosselin 1984, p. 11-409). Polymerized acrylamide is not toxic, but the monomer can cause peripheral nerve damage (*Doull 1980). It is a cumulative neurotoxin and repeated exposure to small amounts may cause serious injury to the nervous system (*Rumack 1975 to Present). The neurological effects may be delayed. Polymer inhibitors or stabilizers added to the monomer may also produce toxicity (*Peer Review Committee). The symptoms of acrylamide toxicity are consistent with mid-brain lesions (*Hamilton 1974) and blocked transport along both motor and sensory axons (*Doull 1980). Medical Conditions Generally Aggravated by Exposure: Individuals with nervous system diseases should not be exposed to acrylamide (*Plunkett 1976). SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 138°C (CC) (*Sunshine 1969) Flammable Limits: LEL: Not Found; UEL: Not Found Extinguishing Methods: For small fires, use dry chemical, carbon dioxide, water spray or foam. For large fires use water spray, fog or foam. Move container from fire area if you can do so without risk (*DOT 1984). Special Fire Fighting Procedures: Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (*DOT 1984). Unusual Fire and Explosion Hazards: Heating to decomposition evolves ammonia, hydrogen and carbon monoxide (*Rumack 1975 to Present). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 79-06-1 Page 3 of 4 ACRYLAMIDE SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Hawley 1977) Conditions to Avoid: Heat (*ACGIH 1980); ultraviolet light (*Merck 1976). Incompatibility (Materials to Avoid): Strong oxidizers (NIOSH/OSHA 1978, P. 42). Hazardous Decomposition or Byproducts: Pure acrylamide will decompose at 175-300°C giving ammonia, hydrogen and carbon monoxide (*Rumack 1975 to Present). Hazardous Polymerization: May Occur: Yes (*ACGIH 1980) May Not Occur: Conditions to Avoid: It readily polymerizes when heated to the melting point or when exposed to ultraviolet light (*Merck 1976). It is known to polymerize with violence when heated (*ACGIH 1980). SECTION VI -- USE INFORMATION Reactive monomer and intermediate in production of organic chemicals, polymers or copolymers (*ACGIH 1980); the latter are used as or in flocculants for sewage and waste treatment; soil conditioning agents; ore processing; adhesives; paper and textile industries; permanent press fabrics (*Hawley 1977). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other non-combustible absorbent materal and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 79-06-1 Page 4 of 4 ACRYLAMIDE SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED** Neoprene POOR/LIMITED** Nitrile POOR/LIMITED** PE POOR/LIMITED** Viton POOR/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 79-06-1 Page 1 of 3 Emergency First Aid Treatment Guide for ACRYLAMIDE (79-06-1) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - White crystalline solid. Odor - None. Commercial Form - Shipped in fiber drums. Uses - Manufacture of polymers, dyes, and adhesives; flocculant for sewage and waste treatment; soil conditioning; ore processing. Caution: Avoid sources of heat including fire. Acrylamide will polymerize violently when heated. Other Names - Acrylic amide, ethylene carboxamide, 2-propenamide. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate. Signs and Symptoms of Acute Acrylamide Exposure: Warning: Effects may be delayed. Caution is advised. Acrylamide is a cumulative neurotoxin. Signs and symptoms of acute exposure may include drowsiness, fatigue, memory loss, confusion, hallucinations, tingling of fingers, loss of vibration and position senses, tremor, muscular weakness, disturbances of balance (especially with the eyes closed), and dysarthria (incoordination of the muscles used for speaking). Excessive sweating of the feet and hands may also occur. Contact with acrylamide may irritate or burn the skin, eyes, and mucous membranes. ------- EFATG CAS Registry Number: 79-06-1 Page 2 of 3 ACRYLAMIDE Emergency Life-Support Procedures: Acute exposure to acrylamide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to acrylamide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to acrylamide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 79-06-1 Page 3 of 3 ACRYLAMIDE Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 79-11-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - CHLOROACETIC ACID CAS Registry Number: 79-11-8 Synonyms: Acetic Acid, Chloro-; alpha-Chloroacetic Acid; Chloracetic Acid; Chloroethanoic Acid; MCA; MKHUK; Monochloracetic Acid; Monochloroacetic Acid; Monochloroacetic Acid Solution; Monochloroethanoic Acid; NCI-C60231 Chemical Formula: C2H3C1O2 Molecular Weight: 94.50 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.18 mg/L TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: 372°F, 189°C (*Merck 1976) Specific Gravity (H2O=1): 1.4043 at 40°C (*Weast 1979) Vapor Pressure (mmHg): 1 at 43°C (*Patty 1963) Melting Point: 145°F, 63°C (*Weast 1979) Vapor Density (AIR=1): 3.26 (*Sax 1975) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Very soluble in water (*Weast 1979) Appearance and Odor: Colorless or white crystals (*Merck 1976). Colorless to light brown crystals (*Hawley 1977). ------- CAS Registry Number: 79-11-8 Page 2 of 4 CHLOROACETIC ACID SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present) Skin: Yes (*Encyc Occupat Health and Safety 1971) Ingestion: Yes (*Encyc Occupat Health and Safety 1971) Health Hazards (Acute, Delayed, and Chronic): This material is very toxic. The probable lethal oral dose is 50-500 mg/kg of body weight, between one teaspoon and one ounce, for a 150 Ib. person. Chloroacetic acid is irritating to the skin, cornea, and respiratory tract and causes burns. It may severely damage skin and mucous membranes. Ingestion may interfere with essential enzyme systems and cause perforation and peritonitis. Burns to skin result in marked fluid and electrolyte loss. Death may follow if more than 3% of the skin is exposed to this material. Other health hazards include central nervous system depression, and respiratory system depression (*Rumack 1975 to Present). Medical Conditions Generally Aggravated by Exposure: Persons with lung diseases are at greater risk (*ITI 1982). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 302°F, 150°C (*NFPA 1978) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Water fog applied gently to surface will cause frothing which will extinguish fire. Normal fire fighting procedures may be used (*NFPA 1978). Extinguish fire using agent suitable for surroundings. Material itself does not burn or burns with difficulty. (*Student 1981) For small fires use dry chemical, carbon dioxide, water spray or foam. For large fires use water spray, fog, or foam (*DOT 1984). Special Fire Fighting Procedures: This material is extremely hazardous to health, but fire fighters may enter areas with extreme care. Full protective clothing including a self-contained breathing apparatus, coat, pants, gloves, boots and bands around legs, arms and waist should be provided. No skin surface should be exposed (*NFPA 1978). Cool fire-exposed containers with water (*Student 1981). Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out (*DOT 1984). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits highly toxic fumes of phosgene and chlorides (*Sax 1975). Water may ------- CAS Registry Number: 79-11-8 Page 3 of 4 CHLOROACETIC ACID SECTION IV (continued) cause frothing if it gets below surface of the liquid and turns to steam (*NFPA 1978). Flammable/poisonous gases may accumulate in tanks and hopper cars. Some of these materials may ignite combustibles, e.g., wood, paper, oil (*DOT 1984). NFPA Flammability Rating: 1 SECTION V « REACTIVITY DATA Stability: Unstable: Stable: Yes (*NFPA 1978) Conditions to Avoid: Heating (*Sax 1975) Incompatibility (Materials to Avoid): It is corrosive to metals (*Student 1981). Hazardous Decomposition or Byproducts: When heated to decomposition, it emits highly toxic fumes of phosgene and chlorides (*Sax 1975). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Chloroacetic acid is used as a pre-emergence herbicide. It is also used as a defoliant (*Martin and Worthing 1974). It is an intermediate for synthetic caffeine (*NIOSH 1984) as well as sarcosine, EDTA, and ethylchloroacetate (*ITI 1982) and sodium carboxymethylcellulose, glycine, thioglycolic acid, Pharmaceuticals like Vitamin A and indigoid dyes (*SRI). Additional uses include disinfectant and as a drying agent for curing hay (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Neutralize spilled materials with crushed limestone, soda ash, or lime (*Student 1981). Waste water containing chloroacetic acid can be treated with ammonia, ammonium salts, or amines followed by separation of suspended solids (*Opavsky 1976). Keep unnecessary people away; isolate hazard and deny entry. Stay upwind; keep out of low areas. Notify authorities if water pollution occurs. Do not touch spilled material. Stop leak if you can without risk. Take up small spills with an absorbent, non-combustible material and place into clean, dry containers for later disposal. Dike large spills far ahead of spill for later disposal (*DOT 1984). ------- CAS Registry Number: 79-11-8 Page 4 of 4 CHLOROACETIC ACID SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) PE POOR/MANY *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 79-11-8 Page 1 of 3 Emergency First Aid Treatment Guide for CHLOROACETIC ACID (79-11-8) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless, white or light brown crystals. Odor - Penetrating; similar to vinegar. Commercial Forms - 99.5% pure liquid or solid in drums. Uses - Chemical intermediate, herbicide, preservative, disinfectant, drying agent for hay, medicinal treatment of keratoses. Caution: Avoid sources of extreme heat including fire. Chloroacetic acid will emit toxic fumes of phosgene and chlorides when heated to decomposition. Other Names - Chloroethanoic acid, MCA, monochloroacetic acid. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W, Ringer's lactate. Signs and Symptoms of Acute Chloroacetic Acid Exposure: Warning: Effects may be delayed. Caution is advised. Chloroacetic acid is extremely corrosive. Signs and symptoms of acute ingestion of Chloroacetic acid may be severe and include salivation, intense thirst, difficulty in swallowing, chills, and shock. Oral, esophageal, and stomach burns are common and often associated with severe pain. Vomitus generally has a coffee-ground appearance. The potential for circulatory collapse is high following ingestion of Chloroacetic acid. Acute inhalation exposure may result in sneezing, hoarseness, choking, laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and chest pain. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur. ------- EFATG CAS Registry Number: 79-11-8 Page 2 of 3 CHLOROACETIC ACID If the eyes have come in contact with chloroacetic acid, then irritation, pain, swelling, corneal erosion, and blindness may result. Dermal exposure may result in dermatitis (red, inflamed skin), severe burns, and pain. Emergency Life-Support Procedures: Acute exposure to chloroacetic acid may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to chloroacetic acid. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to chloroacetic acid. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. ------- EFATG CAS Registry Number: 79-11-8 Page 3 of 3 CHLOROACETIC ACID Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Rinse mouth with large amounts of water. Instruct victims not to swallow this water. 3. DO NOT induce vomiting or attempt to neutralize! 4. Activated charcoal is of no value. 5. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are alert and conscious. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. ------- CAS Registry Number: 79-19-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- THIOSEMICARBAZIDE CAS Registry Number: 79-19-6 Synonyms: l-Amino-2-Thiourea; 1-Aminothiourea; 2-Thiosemicarbazide; Aminothiourea; Hydrazinecarbothioamide; Isothiosemicarbazide; N-Aminothiourea; Thiocarbamoylhydrazine Chemical Formula: CHSN3S Molecular Weight: 91.15 SECTION I ~ REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 9.16 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 356-363°F, 180-184°C (*Hawley 1977) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (*Hawley 1977) Appearance and Odor: This compound is a white crystalline powder and is odorless (*Hawley 1977) ------- CAS Registry Number: 79-19-6 Page 2 of 4 THIOSEMICARBAZIDE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (Sax 1984, p. 2575) Health Hazards (Acute, Delayed, and Chronic): This material is highly toxic by ingestion (Sax 1984, p. 2575). May induce goiter and cause delayed toxic effects in blood and skin (*Rumack 1975 to Present). May be mutagenic in human cells (*NIOSH/RTECS 1985). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Poisonous, Solid, n.o.s) Extinguish with any chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 53). Special Fire Fighting Procedures: (Non-Specific -- Poisonous, Solid, n.o.s.) Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. Move container from fire area if you can do so without risk (DOT 1984, Guide 53). Unusual Fire and Explosion Hazards: When heated to decomposition, very toxic fumes of sulfur oxides and nitrogen oxides are emitted (Sax 1984, p. 2575). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found -; ------- CAS Registry Number: 79-19-6 Page 3 of 4 THIOSEMICARBAZIDE SECTION V (continued) Hazardous Decomposition or Byproducts: When heated to decomposition, thiosemicarbazide emits very toxic fumes of oxides of sulfur and nitrogen (Sax 1984, p. 2575). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION This compound is used as a reagent for ketones and certain metals, for photography and as a rodenticide ("Hawley 1977). It is also effective for control of bacterial leaf blight of rice (*Nippon Noyaku Gakkaishi 1976, 1(2)95). Not a registered pesticide in the U.S. (USEPA/Active Ingredients, 1985). It is a chemical intermediate for herbicides and a reagent for detection of metals (*SRI). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid skin contact, ingestion or inhalation (see Section III above). (Non-Specific — Poisonous Solid, n.o.s.) Do not touch spilled material; stop leak if you can do it without risk. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Thiosemicarbazide may induce goiter and has also been reported to cause bone marrow depression with accompanying decreases in white blood cells and platelets. It may also cause skin irritation (*Rumack 1975 to Present). Emergency and First Aid Procedures: For inhalation, remove victim to fresh air and monitor for breathing difficulty. For eye exposure, irrigate copiously with water for 15 minutes and follow with eye exam if pain persists. For dermal exposure, wash skin twice with water and soap, ------- CAS Registry Number: 79-19-6 Page 4 of 4 THIOSEMICARBAZIDE SECTION IX (continued) followed by exam if pain persists (*Rumack 1975 to Present). (Non-Specific -- Poisonous, Solid, n.o.s.) Call emergency medical care. Remove and isolate contaminated clothing and shoes at the site (DOT 1984, Guide 53). ------- CAS Registry Number: 79-21-0 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PERACETIC ACID CAS Registry Number: 79-21-0 Synonyms: Peroxyacetic Acid; Acetyl Hydroperoxide; Hydroperoxide, Acetyl; Peracetic Acid Solution (Sax 1984, p. 2148); Ethaneperoxoic Acid (Merck 1983, p. 1028) Chemical Formula: C2H4O3 Molecular Weight: 76.05 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.45 ing/liter (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): Yes SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 221°F, 105°C (*Weast 1979) Specific Gravity (H2O=1): 1.226 at 15°C (*Weast 1979) Vapor Pressure (mmHg): Not Found Melting Point: 32°F, 0.1°C (*Weast 1979); approximately -22°F, -30°C (Hawley 1981, p. 786) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Very soluble (*Weast 1979) Appearance and Odor: Colorless liquid (*NFPA 1978). Strong, pungent acrid odor (*CHRIS 197S, *Merck 1983). ------- CAS Registry Number: 79-21-0 Page 2 of 3 PERACETIC ACID SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*NFPA 1978) Skin: Yes (Sax 1984, p. 2148) Ingestion: Yes (*Gosselin 1984) Health Hazards (Acute, Delayed, and Chronic): This is a very toxic compound. The probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150 pound person (*Gosselin 1984). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): (Peracetic Acid, 60% Acetic Acid Solution) 105°F, 41°C (no method given) (NFPA 1984, p. 49-72) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Fight fires from an explosion-resistant location. In advanced or massive fires, area should be evacuated (NFPA 1984, p. 49-72). For small fires: use dry chemical, carbon dioxide, water spray, or foam. For large fires: flood area with water (DOT 1984, Guide 51). Special Fire Fighting Procedures: If fire occurs in the vicinity of this compound, water should be used to keep containers cool. Cleanup and salvage operations should not be attempted until all of the peroxyacetic acid solution has cooled completely (NFPA 1984, p. 49-72). Keep unnecessary people away; wear self-contained breathing apparatus and full protective clothing (DOT 1984, Guide 51). Unusual Fire and Explosion Hazards: Decomposes violently at 230°F, 110°C (NFPA 1984, p. 325M-78). When heated to decomposition, this compound emits acrid smoke and fumes (Sax 1984, p. 2148). Runoff to sewer may create a fire or explosion hazard (DOT 1984, Guide 51). NFPA Flammability Rating: 2 SECTION V - REACTIVITY DATA Stability: Unstable: Yes (NFPA 1984, p. 49-72) Stable: Conditions to Avoid: Shock and heat (NFPA 1984, p. 49-72). ------- CAS Registry Number: 79-21-0 Page 3 of 3 PERACETIC ACID SECTION V (continued) Incompatibility (Materials to Avoid): Powerful oxidizer. Isolate from other stored material, particularly accelerators, oxidizers, and organic or flammable materials (NFPA 1984, p. 49-72). Hazardous Decomposition or Byproducts: Emits acrid smoke and fumes when heated to decomposition (Sax 1984, p. 2148). Hazardous Polymerization: May Occur: May Not Occur: Yes (NFPA 1984, p. 49-72) Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION This compound is used as a bactericide and fungicide, especially in food processing; a reagent in making caprolactam and glycerol; an oxidant for preparing epoxy compounds; a bleaching agent; a sterilizing agent; and a polymerization catalyst for polyester resins (*Hawley 1981; *SRI). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid breathing vapors (see Section III above). Do not touch the spilled material; shut off all ignition sources and stop the leak if this can be done without risk (DOT 1984, Guide 51). The spilled material should be absorbed with a noncombustible absorbent such as vermiculite. Sweep up and place in a metal container for immediate disposal. Do not use spark-generating metals or organic materials for sweeping up or handling spilled material. Dispose of the absorbed peroxyacetic acid solution, in small quantities at a time, by placing it on the ground in a remote outdoor area and igniting with a long torch. Empty containers should be washed with a 10% sodium hydroxide solution (NFPA 1984, p. 49-72). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 79-21-0 Page 1 of 3 Emergency First Aid Treatment Guide for PERACETIC ACID (79-21-0) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Colorless liquid. Odor - Strong, pungent, acrid. Commercial Form - 40% solution in acetic acid contained in 65-lb glass carboys and 250-lb aluminum drums. Uses - Bactericide, fungicide, sterilizing agent, bleaching agent, polymerization catalyst for polyester resins, manufacture of glycerol and epoxy compounds. Materials to Avoid - Organic materials, olefins. Caution: Peracetic acid is a strong oxidizer. Fire or other violent reactions may occur upon contact with combustible organic material. Other Names - Acetic peroxide, acetyl hydroperoxide, Desoxon 1, ethaneperoxoic acid, Obson AC, peroxyacetic acid. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W, Ringer's lactate. Signs and Symptoms of Acute Peracetic Acid Exposure: Signs and symptoms of acute ingestion of peracetic acid may include corrosion of mucous membranes of mouth, throat, and esophagus with immediate pain and dysphagia (difficulty swallowing); ingestion may cause gastrointestinal tract irritation. Inhalation of vapors or fumes may result in respiratory tract irritation; peracetic acid is highly irritating to the skin and eyes. ------- EFATG CAS Registry Number: 79-21-0 Page 2 of 3 PERACETIC ACID Emergency Life-Support Procedures: Acute exposure to peracetic acid may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to peracetic acid. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to peracetic acid. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 79-21-0 Page 3 of 3 PERACETIC ACID Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting or attempt to neutralize! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Activated charcoal is of no value. 5. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 6. Transport to a health care facility. ------- CAS Registry Number: 79-22-1 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- METHYL CHLOROFORMATE CAS Registry Number: 79-22-1 Synonyms: Carbonochloridic Acid, Methyl Ester; Chlorocarbonic Acid, Methyl Ester; Chloroformic Acid Methyl Ester; Formic Acid, Chloro-, Methyl Ester; K-Stoff; Methoxycarbonyl Chloride; Methyl Chlorocarbonate; TL 438 Chemical Formula: C2H3C1O2 Molecular Weight: 94.50 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (mouse) 0.185 mg/liter/2 hours (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1,000 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 160°F, 71.0°C (*Merck 1976) Specific Gravity (H2O=1): 1.223 at 20°C/4°C (*Merck 1976) Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): 3.26 (*Sax 1979) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Slightly soluble (Sax 1984, p. 1826) Appearance and Odor: Clear liquid (*Merck 1976) ------- CAS Registry Number: 79-22-1 Page 2 of 4 METHYL CHLOROFORMATE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Sax 1984, p. 1826) Skin: Yes (Sax 1984, p. 1826) Ingestion: Yes (Sax 1984, p. 1826) Health Hazards (Acute, Delayed, and Chronic): Methyl chloroformate is highly toxic upon inhalation and upon ingestion (*Merck 1976; Sax 1984, p. 1826). A concentration of 1 mg/liter (190 ppm) has been lethal in 10 minutes (*Clayton and Clayton 1981-82). It is corrosive and irritating to skin (*Hawley 1977). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 54°F (no method given) (*Sax 1979) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: For small fires, use dry chemical, carbon dioxide, water spray, and foam. For large fires, use water spray, fog, or foam. Move container from fire area if it can be done without risk. Cool containers exposed to flames with water (DOT 1984, Guide 28). Special Fire Fighting Procedures: Isolate for 1/2 mile in all directions if tank car or truck is involved in fire. Wear positive pressure breathing apparatus and special protective clothing (DOT 1984, Guide 28). Unusual Fire and Explosion Hazards: This chemical is very dangerous when exposed to heat sources, sparks, flame, or oxidizers. It will react with water or steam to produce toxic and corrosive fumes (*Sax 1979). Vapors may travel to a source of ignition and flash back. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire (DOT 1984, Guide 28). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found ------- CAS Registry Number: 79-22-1 Page 3 of 4 METHYL CHLOROFORMATE SECTION V (continued) Conditions to Avoid: Heat or steam should be avoided (*Sax 1979). Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Toxic fumes of phosgene are produced when the material is heated to decomposition. Will react with water or steam to produce toxic and corrosive fumes (*Sax 1979). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Methyl chloroformate is used in organic synthesis and in manufacturing of insecticides (*Hawley 1977). It was used as a warfare agent during World War I (*Clayton and Clayton 1981-82). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid breathing vapors and contact with skin (see Section III above). In case of contact, immediately flush skin or eyes with water. Remove and isolate contaminated clothing. Runoff from fire control or dilution water should be contained for later disposal. In case of a small spill, take up with sand or other noncombustible absorbent material and place in containers for later disposal. In case of a large spill, dike far ahead of the spill for later disposal. In case of spills or leaks, shut off ignition sources, and have no flares, smoking, or flames in hazard area. Do not touch spilled material and use water spray to reduce vapors (DOT 1984, Guide 28). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/LIMITED *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 79-22-1 Page 4 of 4 METHYL CHLOROFORMATE SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: It is an irritant to the skin and is corrosive by ingestion or inhalation. Concentrations of 10 ppm have caused lachrymation and a concentration of 190 ppm for 10 minutes has been lethal to humans. Irritation of the lung and eyes may persist after cessation of exposure. Skin allergies may also occur (*Clayton and Clayton 1981-82). After 2-3 inhalations, brief initial irritation may occur followed by massive symptoms (heavy cough) after 36 hours. Relapses may occur in following days with eventual full recovery (*Schuckmann 1972). Emergency and First Aid Procedures: Move victim to fresh air and call emergency medical care. If not breathing, give artificial respiration; if breathing is difficult, provide oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact, immediately flush skin or eyes with water for at least 15 minutes. Keep victim quiet and maintain normal body temperature. Since effects may be delayed, keep careful watch on the victim (DOT 1984, Guide 28). ------- CAS Registry Number: 80-63-7 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - METHYL 2-CHLOROACRYLATE CAS Registry Number: 80-63-7 Synonyms: 2-Chloroacrylic Acid, Methyl Ester; 2-Propenoic Acid, 2-Chloro-, Methyl Ester; Acrylic Acid, 2-Chloro-, Methyl Ester; Methyl Alpha-Chloroacrylate; Propenoic Acid, 2-Chloro-, Methyl Ester Chemical Formula: C4H5C1O2 Molecular Weight: 120.54 SECTION I ~ REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.5 mg/liter/2 hours (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 126°F, 52°C at 51 mmHg (*Weast 1979) Specific Gravity (H2O=1): 1.189 at 20°C/4°C (*Weast 1979) Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Not Found Appearance and Odor: Colorless liquid (*Lefaux 1968) ------- CAS Registry Number: 80-63-7 Page 2 of 3 METHYL 2-CHLOROACRYLATE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Lefaux 1968) Skin: Yes (*Lefaux 1968) Ingestion: Not Found Health Hazards (Acute, Delayed, and Chronic): It is a skin, eye, and lung irritant. The least trace on skin raises large blisters. It is also a respiratory poison; breathing the vapors can cause pulmonary edema (*Lefaux 1968). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Poisonous Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk (DOT 1984, Guide 55). Special Fire Fighting Procedures: Fight fire from maximum distance. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found ------- CAS Registry Number: 80-63-7 Page 3 of 3 METHYL 2-CHLOROACRYLATE SECTION V (continued) Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Used to make acrylic high polymer with properties closely resembling those of polymethylmethacrylate (*Lefaux 1968). Monomer for specialty polymers (e.g., aircraft glazing) (*SRI). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Poisonous Liquid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: A trace on skin causes large blisters. Inhalation of high concentrations may cause rapid breathing, headache, nausea, lethargy, pulmonary edema, convulsions, and death (Gosselin 1984, p. 11-409). Emergency and First Aid Procedures: (Non-Specific — Poisonous Liquid, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 81-81-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY ~ WARFARIN CAS Registry Number: 81-81-2 Synonyms: Coumarin,3-(alpha-Acetonylbenzyl)-4-Hydroxy-; l-(4'-hydroxy- 3'-coumarinyl)-l-phenyl-3-butanone; 2H-l-benzopyran-2-one, 4-hydroxy-3- (3-oxo-1 -phenylbutyl); 3-( 1 '-pheny 1-2'- acetylethyl)-4-hydroxycoumarin; 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin; 200 Coumarin; Athrombine-K; Brumolin; Compound 42; Coumadin; Coumafen; Coumafene; Coumarin, 3-(alpha- acetonylbenzyl)-4-hydroxy; Coumarin, 4-hydroxy-3(l-phenyl-3-oxo-butyl)-; Coumefene; D-Con; Dethmor; Dethnel; Eastern States Duocide; Fasco Fascrat Powder; Frass-Ratron; Kumader; Kumadu; Kypfarin; Maag Rattentod Cum; Mar-Frin; Maveran; Prothromadin; Rat-a-way; Rat-b-gon; Rat-Gard; Rat-Kill; Rat-Mix; Rat-ola; Ratron; Rats-No-More; Rodafarin; Temus W; Warf 42; Warf Compound 42; Warf-12; Warfarat; Warficide; Zoocoumarin; Co-Rax; Cov-R-Tox; Liqua-Tox; Martin's Mar-Frin; Mouse- Pak; Rat and Mice Bait; Rat-o-cide #2; Rat-trol; Ratorex; Ratox; Ratoxin; Ratron G; Rax; Ro-deth; Rodex, Rodex Blox; Rosex; Rough and Ready Mouse Mix; Solfarin; Spray-trol Brand Roden-trol; Tox-Hid; Twin light rat away; Vampirinip II & III; Waran; Warfarin plus; Warfarin Q; 3-(alpha-Phenyl-beta- Acetylethyl)-4-Hydroxycoumarin; 3-(Acetonylbenzyl)- 4-Hydroxycoumarin; 4-Hydroxy-3(3-oxo-l-Phenylbutyl)-2H-l-Benzopyran-2-one Chemical Formula: C19H16O4 Molecular Weight: 308.32 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.32 mg/liter (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found ------- CAS Registry Number: 81-81-2 Page 2 of 4 WARFARIN SECTION II (continued) Vapor Pressure (mmHg): Not Found Melting Point: 322°F, 161°C (*Merck 1976) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (*Weast 1979) Appearance and Odor: Odorless and colorless solid (*Sax 1984). SECTION III -- HEALTH HAZARD DATA OSHA PEL: TWA 0.1 mg/ms (*NIOSH/RTECS 1985) ACGIH TLV: TWA 0.1 mg/ms; STEL 0.3 mg/ms (*ACGIH 1980) IDLH: 200 mg/ms (*NIOSH/OSHA 1981) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Yes (*Arena 1974) Ingestion: Yes (*Morgan 1982) Health Hazards (Acute, Delayed, and Chronic): It is classified as very toxic. Probable oral lethal dose in humans is 50-500 mg/kg, between 1 teaspoon and 1 ounce for a 150 Ib. person (*Gosselin 1976). Material is an .anticoagulant. Toxic effects other than hemorrhage are rarely seen in humans (*Goodman 1975). Material is believed to be teratogenic in humans (*Hayes 1982). Medical Conditions Generally Aggravated by Exposure: Persons with a history of blood disorders with bleeding tendencies would be expected to be at increased risk from exposure (*NIOSH/OSHA 1981). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific - Poison B Solid) Extinguish fire using agent suitable for type of surrounding fire. Use alcohol foam, carbon dioxide, or dry chemical (Student 1981, p. 416). Special Fire Fighting Procedures: (Non-Specif ic -- Poison B Solid) Wear full protective clothing and self-contained breathing apparatus (Student 1981, p. 416). ------- CAS Registry Number: 81-81-2 Page 3 of 4 WARFARIN SECTION IV (continued) Unusual Fire and Explosion Hazards: Contact with strong oxidizers may cause fires and explosions (*NIOSH/OSHA 1981). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Strong oxidizers (*NIOSH/OSHA 1981) Hazardous Decomposition or Byproducts: Toxic gases and vapors (e.g., carbon monoxide) may be released in heating to decomposition (*NIOSH/OSHA 1981). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Material is used as a rodenticide for Norway rats and for house mice (*SRI). SECTION VII ~ PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material (see Section III above). Eating and smoking should not be permitted in areas where it is handled, processed or stored. For small spills: sweep onto paper or other suitable material. Place in an appropriate container and burn in a safe place. Large quantities may be destroyed by dissolving in a flammable solvent (e.g., alcohol) and atomizing in a combustion chamber (*NIOSH/OSHA 1981). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 81-81-2 Page 4 of 4 WARFARIN SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms begin a few days or weeks after ingestion. They include nose bleed, bleeding gums, pallor, and sometimes hematomas around joints and on buttocks, blood in urine and feces. Later, paralysis due to cerebral hemorrhage, and finally hemorrhagic shock and death may occur (*Doull 1980). Emergency and First Aid Procedures: (Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 82-66-6 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- DIPHACINONE CAS Registry Number: 82-66-6 Synonyms: . 1,3-Indandione, 2-Diphenylacetyl-; 2-(DiphenyIacetyl)-lH-Indene- l,3(2H)-Dione; 2-(Diphenylacetyl)Indan-l,3-Dione; 2-Diphenylacetyl-l,3- Diketohydrindene; 2-Diphenylacetyl-l,3-Indanedione; Diandin; Didandin; Didion; Difacione; Dipaxin; Diphacin; Diphenacin; Diphenandione; Oragulant; PID; Promar; Ramik; Ratindan 1; Solvan; U1363; lH-Indene-l,3(2H)-Dione, 2-(Diphenylacetyl)- Chemical Formula: C23H16O3 Molecular Weight: 340.38 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mammal) 0.91 mg/kg (*NIOSH/RTECS 1985) TPQ: 10/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 295-297°F, 146-147°C (*Merck 1976) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Practically insoluble (*Merck 1976); 17 mg/liter (Farm Chemicals Handbook 1984, p. C-82) ------- CAS Registry Number: 82-66-6 Page 2 of 3 DIPHACINONE SECTION II (continued) Appearance and Odor: Pale yellow crystals (*Merck 1976); odorless (*Osol 1975) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (Sax 1984, p. 1231) Health Hazards (Acute, Delayed, and Chronic): This material is extremely toxic; probable oral lethal dose in humans is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Many medical conditions will be aggravated by this material (*Goodman 1980). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: The material is similar to coumarin and indandione (*Morgan 1982). (Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition it emits acrid smoke and fumes (Sax 1984, p. 1231). NFPA Flammability Rating: Not Found -; ------- CAS Registry Number: 82-66-6 Page 3 of 3 DIPHACINONE SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Worthing 1979) Conditions to Avoid: Sensitive to light (*Worthing 1979) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits acrid smoke and fumes (Sax 1984, p. 1231). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Rodenticide (*Worthing 1979); and anticoagulant medication (*Merck 1976). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX — EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 82-66-6 Page 1 of 3 Emergency First Aid Treatment Guide for DIPHACINONE (82-66-6) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized .authority. Substance Characteristics: Pure Form - Pale yellow crystals. Odor - None. Commercial Forms - 95% pure yellow powder, 5-mg tablets. Use - Rodenticide. Other Names - Diandin; Didandin; Diphacin; Diphenadione; 2-diphenylacetyl-l,3- indanedione; Promar; Ramik; Solvan. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, vitamin K (phytonadione). Signs and Symptoms of Acute Diphacinone Exposure: Diphacinone is an anticoagulant. Hemorrhage is the most common effect and may be manifested by nose bleeding, gum bleeding, bloody stools and urine, ecchymoses (extravasations of blood into skin), and hemoptysis (coughing up of blood). Bruising is heightened. Abdominal and flank pain are also common. Other signs and symptoms include flushing, dizziness, hypotension (low blood pressure), dyspnea (shortness of breath), cyanosis (blue tint to the skin and mucous membranes), fever, and diarrhea. Emergency Life-Support Procedures: Acute exposure to diphacinone may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment shouldf also be worn, as necessary. Rescue vehicles ------- EFATG CAS Registry Number: 82-66-6 Page 2 of 3 DIPHACINONE should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to diphacinone. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to diphacinone. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas twice with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital ------- EFATG CAS Registry Number: 82-66-6 Page 3 of 3 DIPHACINONE for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of diphacinone is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of diphacinone may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. RUSH to a health care facility. ------- CAS Registry Number: 86-50-0 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- AZINPHOS-METHYL CAS Registry Number: 86-50-0 Synonyms: Methyl Guthion; l,2,3-Benzotriazin-4(3H)-one, 3-(Mercapto- methyl)-, O,O-Dimethyl Phosphorodithioate; 3-(Mercaptomethyl)-1,2,3- Benzotriazin-4(3H)-one O,O- Dimethyl Phosphorodithioate S-Ester; Bay 17147; Bay 9027; Bayer 17147; Bayer 9027; Benzotriazine Derivative of a Methyl Dithiophosphate; Benzotriazinedithiophosphoric Acid Dimethoxy Ester; Carfene; Cotneon; Cotnion; Cotnion Methyl; Crysthion 2L; Crysthyon; DBD; Dimethyldithiophosphoric Acid N-Methylbenzazimide Ester; ENT 23,233; Gothnion; Gusathion; Gusathion 25; Gusathion K; Gusathion M; Gusathion Methyl; Gusathion-20; Guthion; Methyl Azinphos; Methyl Gusathion; Metiltriazotion; N-Methylbenzazimide, Dimethyldithiophosphoric Acid Ester; NCI-C00066; O,O-Dimethyl S-(3,4-Dihydro-4-Keto-l,2,3-Benzotriazinyl-3-Methyl) Dithiophosphate; O,O-Dimethyl S-(4-Oxo-l,2,3-Benzotriazino(3)-Methyl) Thiothionophosphate; O,O-Dimethyl S-(4-Oxo-3H-l,2,3-Benzotriazine-3-Methyl) Phosphorodithioate; O,O-Dimethyl S-(4-Oxobenzotriazino-3-Methyl) Phosphorodithioate; O,O-Dimethyl S-4-Oxo-l,2,3-Benzotriazin-3(4H)-ylmethyl Phosphorodithioate; O,O-Dimethyl-S-(l,2,3-Benzotriazinyl-4-Keto)Methyl Phosphorodithioate; O,O-Dimethyl-S-(Benzaziminomethyl) Dithiophosphate; Phosphorodithioic Acid, O,O-Dimethyl Ester, S-Ester With 3-(Mercaptomethyl)- l,2,3-Benzotriazin-4(3H)-one; Phosphorodithioic Acid, O,O-Dimethyl S-((4-Oxo- l,2,3-Benzotriazin-3(4H)-yl)Methyl) Ester; Phosphorodithioic Acid, O,O- Dimethyl S-(4-Oxo-l,2,3-Benzotriazin-3(4H)-ylmethyl)Ester; R 1582; S-(3,4-Dihydro-4-Oxo-l,2,3-Benzotriazin-3-ylmethyl) O,O-Dimethyl Phosphorodithioate; S-(3,4-Dihydro-4-Oxo-Benzo(alpha)-(l,2,3-Triazin-3-yl Methyl) O,O-Dimethyl Phosphorodithioate Chemical Formula: C10H12N3O3PS2 Molecular Weight: 317.34 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC60 inhalation (rat) 0.069 mg/liter/1 hour (*NIOSH/RTECS 1985) TPQ: 10/10,000 (pounds) RQ: 1 (pounds) Section 313 Listed (Yes or No): No ------- CAS Registry Number: 86-50-0 Page 2 of 4 AZINPHOS-METHYL SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 1.44 at 20°C/4°C (*Merck 1983) Vapor Pressure (mmHg): Negligible at 20°C (*Worthing 1979) Melting Point: 163-165°F; 73-74°C (*Merck 1983) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 33 ppm at room temperature (*Worthing 1979) Appearance and Odor: White crystals (*Worthing 1979) or brown waxy solid (*Hawley 1981) SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.2 mg/m3 (NIOSH 1987, p.54) ACGIH TLV: TWA 0.2 mg/m3 (ACGIH 1986-87, p. 10) IDLH: 5 mg/m3 (NIOSH 1987, p.54) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Hayes 1982, p. 358) Skin: Yes (Hayes 1982, p. 358) Ingestion: Yes (Hayes 1982, p. 358) Health Hazards (Acute, Delayed, and Chronic): Acute: extremely toxic. Probable oral lethal dose in humans is 5-50 mg/kg, or between 7 drops and 1 teaspoon for a 70 kg (150 Ib.) person. A potent ch'olinesterase inhibitor which can cause death (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam (*DOT 1984). ------- CAS Registry Number: 86-50-0 Page 3 of 4 AZINPHOS-METHYL SECTION IV (continued) Special Fire Fighting Procedures: Move containers from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (*DOT 1984). Unusual Fire and Explosion Hazards: Some of the formulations may burn, but none of them ignite easily. Container may explode in the heat of the fire (*DOT 1984). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Unstable at temperatures above 390°F (200°C) (*Worthing 1979) Stable: Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Rapidly hydrolyzed by cold alkali or cold acid (*Worthing 1979) Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Insecticide for control of pests on a wide range of crops. Used to control boll weevil on cotton, and for control of insects on deciduous fruits, nuts, vegetables, field crops, citrus, and for non-agricultural use (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site (*DOT 1984). Do not touch spilled material. Stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (*DOT 1984). ------- CAS Registry Number: 86-50-0 Page 4 of 4 AZINPHOS-METHYL SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 86-50-0 Page 1 of 3 Emergency First Aid Treatment Guide for AZINPHOS-METHYL (86-50-0) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - White crystals. Commercial Forms - Waxy brown solid, 50% wettable powder or water emulsion. Use - Insecticide. Other Names - l,2,3-Benzotriazin-4(3H)-one, 3-(mercaptomethyl)-, O,O-dimethyl phosphorodithioate; Carfene; Cotneon; Cotnion-Methyl; Crysthyon; Gusathion M; Guthion. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Azinphos-Methyl Exposure: Warning: Effects may be delayed up to 12 hours. Caution is advised. Note: Azinphos-methyl is a cholinesterase inhibitor. Acute exposure to azinphos-methyl may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur. ------- EFATG CAS Registry Number: 86-50-0 Page 2 of 3 AZINPHOS-METHYL Emergency Life-Support Procedures: Acute exposure to azinphos-methyl may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to azinphos-methyl. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to azinphos-methyl. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least IS minutes. 5. Wash exposed skin areas three times with soap and water., 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 86-50-0 Page 3 of 3 AZINPHOS-METHYL Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of azinphos-methyl is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of azinphos-methyl may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 86-88-4 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ANTU CAS Registry Number: 86-88-4 Synonyms: Urea, l-(l-Naphthyl)-2-Thio-; alpha-Naphthylthiourea; l-(l-Naphthyl)-2-Thiourea; l-(l-Naphthyl)Thiourea; 1-Naphthyl Thiourea; 1-Naphthylthiourea; alpha-Naphthothiourea; alpha-Naphthylthiocarbamide; alphanaphthyl Thiourea; Alrato; Anturat; Bantu; Chemical 109; Dirax; Kill Kantz; Kripid; Krysid; Krysid PI; N-(l-Naphthyl)-2-Thiourea; N-1-Naphthylthiourea; Naphtox; Rat-Tu; Rattrack; Smeesana; Thiourea, 1-NaphthalenyI-; U-5227; USAF EK-P-5976 Chemical Formula: CnH10N2S Molecular Weight: 202.23 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (dog) 0.38 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): 0 at 25°C (*Sax 1975) Melting Point: 388°F, 198°C (*Merck 1976) Vapor Density (AIR=1): 6.99 (*NIH EPA, OHM/TADS 1984) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 0.6 g/L water at 25°C (*Merck 1976) ------- CAS Registry Number: 86-88-4 Page 2 of 3 ANTU * SECTION II (continued) Appearance and Odor: White crystal or powder; technical product is gray powder (*Clarke 1981). No odor (*ACGIH 1980); bitter taste (*Merck 1976). i SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.3 mg/m8 (*NIOSH/RTECS 1985) ACGIH TLV: TWA 0.3 mg/ms (ACGIH 1986-87, p.10) IDLH: 100 mg/ms (*NIH EPA, OHM/TADS 1984) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present) Skin: Yes (*Rumack 1975 to Present) Ingestion: Yes (*Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): Moderately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or 1 Ib.) for 150 Ib. person (*Gosselin 1976). Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours (*Rumack 1975 to Present). Medical Conditions Generally Aggravated by Exposure: People with chronic respiratory disease or liver disease may be especially at risk (*NIOSH/OSHA 1981). SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): May burn but will not ignite readily (*DOT 1984) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam (*DOT 1984). Special Fire Fighting Procedures: Stay upwind, and out of low areas. Wear self-contained breathing apparatus and full protective clothing (*DOT 1984). Unusual Fire and Explosion Hazards: Emits toxic fumes upon decomposition (*Sax 1975). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 86-88-4 Page 3 of 3 ANTU SECTION V -- REACTIVITY DATA Stability: Unstable: Stable: Yes (*Worthing 1979) Conditions to Avoid: Decomposing heat (*Sax 1975) Incompatibility (Materials to Avoid): It reacts with silver nitrate and strong oxidizers (*Sax 1975) Hazardous Decomposition or Byproducts: When heated it emits sulfur dioxide, oxides of nitrogen, and carbon monoxide (*NIOSH/OSHA 1981). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI ~ USE INFORMATION This material was used primarily as a rodenticide for control of adult Norway rats. It is not produced commercially in the U.S. (*SRI). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation and skin contact (see Section III above). Do not touch spilled material, stay upwind, keep out of low areas, deny entry (*DOT 1984). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms include seizures, pulmonary edema and dermal irritation (*Rumack 1975 to Present). Ingestion may cause vomiting, shortness of breath, and bluish discoloration of the skin (*NIOSH/OSHA 1981). Emergency and First Aid Procedures: Move victim to fresh air. Treat pulmonary edema with positive pressure oxygen (*Rumack 1975 to Present). Immediately flush with fresh water for at least 15 minutes in case of skin or eye contact (*Gosselin 1976). ------- CAS Registry Number: 144-49-0 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDE TY -- FLUOROACETIC ACID CAS Registry Ni? •-: 144-49-0 Synonyms: Ace d, Fluoro-; 2-Fluoroacetic Acid; alpha-Fluoroacetic Acid; Cymonic Acid; , uoroethanoic Acid; Gifblaar Poison; HFA; MFA; Monofluoroacetic n Chemical Formula: C2HSFO2 Molecular Weight: 78.04 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (guinea pig) 0.468 mg/kg (*NIOSH/RTECS 1985) TPQ: 10/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: 329°F, 165°C (*Weast 1979) Specific Gravity (H2O=1): 1.3693 at 97°F, 36°C (*Weast 1979) Vapor Pressure (mmHg): Not Found Melting Point: 95.4°F, 35.2°C (*Weast 1979) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (Weast 1983, p. 597) Appearance and Odor: Colorless crystals (*Hawley 1977) ------- CAS Registry Number: 144-49-0 Page 2 of 4 FLUOROACETIC ACID SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.05 mg/ms (for sodium salt) (OSHA 1984, p. 663) ACGIH TLV: TWA 0.05 mg/ms; STEL 0.15 mg/ms (for sodium salt) (*ACGIH 1980) IDLH: Not Found Other Limits Recommended: IDLH for sodium salt: 5 mg/ms (NIOSH/OSHA 1978, p. 166). Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Yes (*Rumack 1975 to Present) Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): This material is very toxic; ingestion of small quantities may cause death (*Sax 1975). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: Burns (*Merck 1976) LEL: Not Found UEL: Not Found Extinguishing Methods: Small fires: use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam (DOT 1984, Guide 59). Special Fire Fighting Procedures: Stay upwind; keep out of low areas. Wear self-contained, positive pressure breathing apparatus and full protective clothing. Move container from fire area. Cool containers that are exposed to flames with water from the side until well after fire is out (DOT 1984, Guide 59). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits highly toxic fumes of fluorine containing compounds (*Sax 1979). Some of these materials may burn but none ignite readily. These materials may ignite combustibles (wood, paper, oil, etc.) (DOT 1984, Guide 59). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Encyc Occupat Health and Safety 1971) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found ------- CAS Registry Number: 144-49-0 Page 3 of 4 FLUOROACETIC ACID SECTION V (continued) Hazardous Decomposition or Byproducts: When heated to decomposition, it emits highl- xic fumes of fluorine containing compounds (*Sax 1979). Hazardous 1 merization: May Occur: Not Found May Not Occur: Not Found Conditn to Avoid: Not Found SECTION VI - " INFORMATION Rodenticide (Hawley 1981, p. 470). The sodium salt of this material is used as a rodent poison (*Patty 1963). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material. Stop leak if you can do so without risk. Stay upwind; keep out of low areas. Use water spray to reduce vapors. For small spills, take up with sand or other noncombustible absorbent material and place into containers for later disposal. For large spills, dike spill for later disposal (DOT 1984, Guide 59). SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED** Butyl/Neoprene GOOD/LIMITED** CPE GOOD/LIMITED** Neoprene GOOD/LIMITED** Nitrile GOOD/LIMITED** PE POOR/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 144-49 Page 4 of 4 FLUOROACETIC ACID SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: The major symptoms of fluoroacetic acid poisoning include severe epileptiform convulsions alternating with coma and depression; death may result from asphyxia during convulsion or from respiratory failure. Cardiac irregularities, such as ventricular fibrillation and sudden cardiac arrest, nausea, vomiting, excessive salivation, numbness, tingling sensations, epigastric pain, mental apprehension, muscular twitching, low blood pressure, and blurred vision may also occur (*Encyc Occupat Health and Safety 1971). Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature (DOT 1984, Guide 59). ------- CAS Registry Number: 149-74-6 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDE HTY - DICHLOROMETHYLPHENYLSILANE CAS Registry Ni- ? ?r: 149-74-6 Synonyms: Met >henyldichlorosilane; Phenylmethyldichlorosilane; Silane, Dichloromethylp. yl- Chemical Formula: C7H8Cl2Si Molecular Weight: 191.14 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LClow inhalation (mouse) 0.2 mg/liter/2 hours (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 401°F, 205°C (Hawley 1981, p. 688) Specific Gravity (H2O=1): 1.19 (*Hawley 1977) Vapor Pressure (mmHg): 1.0 at 35.7°C (Perry 1984, p. 3-54) Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Not Found Appearance and Odor: Colorless liquid (*Hawley 1977) ------- CAS Registry Number: 149-74-6 i*age 2 of 3 DICHLOROMETHYLPHENYLSILANE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present) Skin: Yes (*Rumack 1975 to Present) Ingestion: Yes (*Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): The chemical is toxic and is an irritant (*Hawley 1977). Contact may cause burns to the skin and eyes (DOT 1984, Guide 29). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 83°F (28°C) (*Hawley 1977) (SUSPECT) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: For small fires, use dry chemical, carbon dioxide, water spray or foam. For large fires, use water spray, fog, or foam (DOT 1984, Guide 29). Special Fire Fighting Procedures: Isolate for 1/2 mile in all directions if tank car or truck is involved in a fire. Wear self-contained (positive pressure) breathing apparatus with full protective clothing. Do not get water inside container (DOT 1984, Guide 29). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits toxic fumes of chlorine-containing compounds (Sax 1984, p. 951). Flammable/combustible material; may be ignited by heat, sparks, or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Fire may produce irritating or poisonous gases (DOT 1984, Guide 29). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found > ------- CAS Registry Number: 149-74-6 Page 3 of 3 DICHLOROMETHYLPHENYLSILANE SECTION V (continued) Incompatibility (Materials to Avoid): Reacts strongly with oxidizing materials (*F- 'ey 1977) Hazardous i rnposition or Byproducts: When heated to decomposition, it emits toxic i ;s of chlorine-containing compounds (Sax 1984, p. 951). Hazardous P .^erization: May Occur: Not Found May Not Occur: Not Found Conditi to A>oid: Not Found SECTION VI - USE INFORMATION Used in the manufacture of silicones ("Hawley 1977); and as a chemical intermediate for silicone fluids, resins and elastomers (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away. Stay upwind. Stay out of low areas. Shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors; do not get water inside container. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 29). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Not Found Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material; immediately flush skin or eyes with running water for at least 15 minutes. Keep victim quiet and maintain normal body temperature (DOT 1984, Guide 29). ------- CAS Registry Number: 151-38-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - METHOXYETHYLMERCURIC ACETATE CAS Registry Number: 151-38-2 Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 657) Mercury, (Acetato)(2-Methoxyethvi -; Acetato(2-Methoxyethyl)Mercury; Landisan; MeEHg; MEMA; Mercuran; Mercury, Acetoxy(2-Methoxyethyl)-; Radosan; Methoxyethyl Mercuric Acetate (Farm Chemicals Handbook 1984, p. CHS) Panogen Chemical Formula: C5H10HgOs Molecular Weight: 318.74 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 16 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): In Mercury Compounds category SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (Sax 1984, p. 1776) Appearance and Odor: Crystals (Sax 1984, p. 1776) ------- CAS Registry Number: 151-38-,. Page 2 of 4 METHOXYETHYLMERCURIC ACETATE SECTION III -- HEALTH HAZARD DATA OSHA PEL: (Mercury alkyl compounds) TWA 0.01 mg/m3, as mercury; Ceiling 40 mg/ms, as mercury (NIOSH 1987, p. 152) ACGIH TLV: (Mercury alkyl compounds) TWA 0.01 mg/ms, as mercury; STEL 30 mg/ms, as mercury (skin) (ACGIH 1986-87, p. 22) IDLH: (Mercury alkyl compounds) 10 mg/ms, as mercury (NIOSH 1987, p. 152) Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Encyc Occupat Health and Safety 1983, p. 1337) Skin: Yes (Non-Specific — Mercury Compounds) (Hayes 1982, pp. 15-16) Ingestion: Yes (Encyc Occupat Health and Safety 1983, p. 1337) Health Hazards (Acute, Delayed, and Chronic): Highly toxic (Hawley 1981, p. 664). Target organs are brain and central nervous system (Hayes 1982, pp. 18-19). Inhalation can cause lung damage; ingestion can cause kidney damage. Women of childbearing age should avoid exposure (Encyc Occupat Health and Safety 1983, p. 1337). Medical Conditions Generally Aggravated by Exposure: Women of childbearing age and persons with eczema, renal or neurological disorders should not be exposed to mercurials (Encyc Occupat Health and Safety, 1983, p. 1337). SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: This is an alkyl mercury pesticide (Hayes 1982, p. 20). Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution (DOT 1984, Guide 55). Special Fire Fighting Procedures: This* is an alkyl mercury pesticide (Hayes 1982, p. 20). Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site. If water pollution occurs, notify appropriate authorites (DOT 1984, Guide 55). ------- CAS Registry Number: 151-38-2 Page 3 of 4 METHOXYETHYLMERCURIC ACETATE SECTION IV (continued) Unusual Fire and Explosion Hazards: When heated to decomposition, it emits toxic fumes of mercury (Sax 1984, p. 1776). This material may burn but does not ignite readily. Container may explode in heat of fire (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Uns^ble: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition it emits toxic fumes of mercury (Sax 1984, p. 1776). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Used as a pesticide in seed treatment for cotton and small grains. It is no longer approved for this use (Farm Chemicals Handbook 1984, pp. C144-148). It exhibits high fungicidal activity against leaf stripe of barley, stinking smut of wheat, snow mold of rye; against seedling diseases in beets and legumes, and for dressing "seed" potatoes, bulbs, and tubers (Buchel 1983, pp. 250-51). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) This is an alkyl mercury pesticide (Hayes 1982, p. 20). Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). ------- CAS Registry Number: Page 4 of 4 METHOXYETHYLMERCURIC ACETATE SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATIC. Signs and Symptoms of Exposure: This is an alkyl mercu.y pesticide. Patients complain of headache, paresthesia of tongue, lips, fingers, and toes, a metallic taste in mouth, gastrointestinal disturbances, gas, and diarrh.ea. Nervous system symptoms may appear first after a relatively slight exposure or have a latency period of several weeks. These symptoms include fine tremors of extended hands, loss of side vision, slight loss of coordination, loss of coordination of speech, writing and gait. Uncoordination may progress to loss of ability to control voluntary movements. Irritability and bad temper may progress to mania. Stupor or coma may develop. Blisters or dermatitis may be present on skin. Symptoms persist for years even in cases of mild exposure (Hayes 1982, pp. 20-21). Emergency and First Aid Procedures: This is an alkyl mercury pesticide (Hayes 1982, p. 20). Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). COMMENTS Sources searched but no information found: Weast 1979 ACGIH 1983 NIOSH/OSHA 1978 Weiss 1980 Merck 1983 Clayton and Clayton 1981-82 Student 1981 ------- CAS Registry Number: 151-50-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - POTASSIUM CYANIDE CAS Registry Number: 151-50-8 Synonyms: Cyanide of Potassium; Hydrocyanic Acid, Potassium Salt; Potassium Cyanide (KCN) Chemical Formula: KCN Molecular Weight: 65.11 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD60 oral (rabbit) 5 mg/kg (*NIOSH/RTECS 1985) TPQ: 100 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 1.52 at 16°C (Weast 1978, p. B150) Vapor Pressure (mmHg): Not Found Melting Point: 1173°F, 634°C (*Merck 1976) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble in 2 parts cold water or 1 part boiling water (*Merck 1976) Appearance and Odor: White granular powder or lumps with faint odor of bitter almonds (*Merck 1976,* Hawley 1977) ------- CAS Registry Number: 151-50-8 Page 2 of 4 POTASSIUM CYANIDE SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 5 mg/ms as cyanide (*NIOSH/RTECS 1985) ACGIH TLV: (Cyanides) TWA 5 mg/ms as cyanide (skin) (ACGIH 1986-87, p. 14) IDLH: 50 mg/ms (NIOSH/OSHA 1978, p. 74) Other Limits Recommended: NIOSH Occupational Exposure Recommended Standard -- Air Ceiling 5 mg/ms as cyanide, 10 minutes (*NIOSH/RTECS 1985) Routes of Entry: Inhalation: Not Found Skin: Yes (*Merck 1976) Ingestion: Yes (*Merck 1976) Health Hazards (Acute, Delayed, and Chronic): It is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or less than a taste (7 drops) for a 150 Ib. person (*Gosselin 1976). It is an eye and skin irritant (*Grant 1974, *Encyc Occupat Health and Safety 1971).. Poisonous in very small quantities; a taste is lethal (*Gosselin 1984). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not flammable (*NFPA 1978) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Water may be used on fire in an area containing potassium cyanide (*NFPA 1978). Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: Wear full protective clothing (*NFPA 1978). Wear positive pressure breathing apparatus and special protective clothing. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: Contact with acid releases highly flammable hydrogen cyanide gas (*NFPA 1978). Moisture may cause this material to volatilize as hydrogen cyanide (*Peer Review Committee). NFPA Flammability Rating: 0 SECTION V -- REACTIVITY DATA Stability: Unstable: Stable: Yes (Weiss 1980, p. 766) Conditions to Avoid: Avoid contact with acids (see Section *V above) ------- CAS Registry Number: 151-50-8 Page 3 of 4 POTASSIUM CYANIDE SECTION V (continued) Incompatibility (Materials to Avoid): Reacts with acids to produce hydrogen cyanide gas (*NFPA 1978). Reacts with strong oxidizers such as nitrates and chlorates (NIOSH/OSHA 1978, p. 74); nitrogen trichloride; perchloryl fluoride; sodium nitrate; acids; alkaloids; chloral hydrate; iodine (Sax 1984, p. 2273). Hazardous Decomposition or Byproducts: When heated to decomposition, it emits very toxic fumes of cyanide and nitrogen oxides (Sax 1984, p. 2273). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Potassium cyanide is used for electroplating, steel hardening, extraction of gold and silver from ores, manufacture of some chemicals, and fumigation (*Encyc Occupat Health and Safety 1971). SECTION VII ~ PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid water. Cover spilled material with alkali or sodium thiosulfate (*Rumack 1975 to Present). Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place materials into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) PVC GOOD/LIMITED* *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 151-50-8 Page 4 of 4 POTASSIUM CYANIDE SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 151-50-8 Page 1 of 4 Emergency First Aid Treatment Guide for POTASSIUM CYANIDE (151-50-8) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Caution: Potassium cyanide toxicity can occur via ingestion, dermal/eye contact, or inhalation; death may occur within minutes. IMMEDIATELY begin administering 100% oxygen and RUSH victims to a health care facility! Substance Characteristics: Pure Forms - White, amorphous, deliquescent lumps or crystalline mass. Odor - Faint odor of bitter almonds. Commercial Forms - Pure form, solution, or reagent in 25- and 100-pound drums. Uses - Electroplating, steel hardening, gold and silver extraction, fumigation, insecticide, chemical intermediate. Materials to Avoid - Acids. Caution: Avoid sources of extreme heat including fire. Potassium cyanide will emit toxic cyanide and nitrogen oxide fumes when heated to decomposition. Other Names - Cyanide of potassium; hydrocyanic acid, potassium salt. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium bicarbonate, diazepam, phenytoin. Signs and Symptoms of Acute Potassium Cyanide Exposure: Warning: Effects may be delayed. Caution is advised. Vital signs should be monitored closely. Heart palpitation may occur within minutes after exposure. ------- EFATG CAS Registry Number: 151-50-8 Page 2 of 4 POTASSIUM CYANIDE Signs and symptoms of acute exposure to potassium cyanide may include hypertension (high blood pressure) and tachycardia (rapid heart rate), followed by hypotension (low blood pressure) and bradycardia (slow heart rate). Cardiac arrhythmias and other cardiac abnormalities are common. Cyanosis (blue tint to the skin and mucous membranes), and cherry-red or bloody mucous membranes may appear. Tachypnea (rapid respiratory rate) may be followed by respiratory depression. Lung hemorrhage and pulmonary edema may occur. Headache, vertigo (dizziness), agitation, and giddiness may precede combative behavior, convulsions, paralysis, protruding eyeballs, dilated and unreactive pupils, and coma. Potassium cyanide is irritating to the skin, eyes, and mucous membranes. Lacrimation (tearing) and a burning sensation of the mouth and throat are common. Salivation, nausea, and vomiting may also occur. Emergency Life-Support Procedures: Acute exposure to potassium cyanide may require decontamination and life support for the victims. All exposed persons should be transported to a health care facility as quickly as possible. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air- purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to potassium cyanide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with potassium cyanide- contaminated persons or their gastric contents can result in self- poisoning. 3. RUSH to a health care facility! 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. ------- EFATG CAS Registry Number: 151-50-8 Page 3 of 4 POTASSIUM CYANIDE Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to potassium cyanide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen ma$k. Direct oral contact with potassium cyanide- contaminated persons or their gastric contents can result in self- poisoning. 3. RUSH to a health care facility! 4. Remove contaminated clothing as soon as possible. 5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 6. Wash exposed skin areas twice with soap and water. 7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a •forced-oxygen mask. Direct oral contact with potassium cyanide- contaminated persons or their gastric contents can result in self- poisoning. 2. RUSH to a health care facility! 3. DO NOT induce vomiting. Ipecac is not recommended for ingestion of potassium cyanide. 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. ------- CFATG CAS Registry Number: 151-50-8 Page 4 of 4 POTASSIUM CYANIDE 6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. ------- CAS Registry Number: 151-56-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ETHYLENEIMINE CAS Registry Number: 151-56-4 Synonyms: (N1OSH/RTECS 1983 Synonyms, Volume 2, p. 291) Aminoethylene; Azacyclopropane; Azirane; Aziridine; IH-Azirine, dihydro-; Dihydroazirene; Dimethyleneimine; Dimethylenimine; El; Ethylenimine; ENT-50324, Ethylimine. Chemical Formula: C2H5N Molecular Weight: 43.07 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.1 mg/liter/2 hours (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory); 1 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 131-133°F, 55-56°C (Clayton and Clayton 1981-82, p. 2673) Specific Gravity (H2O=1): 0.8321 at 20°C (Clayton and Clayton 1981-82, p. 2673) Vapor Pressure (mmHg): 160 at 20°C (Clayton and Clayton 1981-82, p. 2673) Melting Point: -98°F, -72°C (Freezing Point) (Clayton and Clayton 1981-82, p. 2673) Vapor Density (AIR=1): 1.48 (Clayton and Clayton 1981-82, p. 2673) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Miscible (Merck 1983, p. 3744) ------- CAS Registry Number: 151-56-4 iage 2 of 4 ETHYLENEIMINE SECTION II (continued) Appearance and Odor: Colorless, mobile fluid with a strong ammoniacal odor (Clayton and Clayton 1981-82, p. 2673; Merck 1983, p. 3744) SECTION III - HEALTH HAZARD DATA OSHA PEL: Occupational carcinogen; no permissible exposure limit (NIOSH 1987, Appendix C) ACGIH TLV: TWA O.Sppm (1.0 mg/ms) (skin) (ACGIH 1986-87, p. 19) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Weiss 1980, p. 443) Skin: Yes (Weiss 1980, p. 443) Ingestion: Yes (Weiss 1980, p. 443) Health Hazards (Acute, Delayed, and Chronic): Ethyleneimine is classified as extremely toxic with a probable oral lethal dose of 5-50 mg/kg which is approximately 7 drops to 1 teaspoonful for a 70 kg (150 Ib.) person (*Gosselin 1976). Ethyleneimine gives inadequate warning when over-exposure is by inhalation or skin absorption. It is a severe blistering agent, causing third degree chemical burns of the skin. Also, it has a corrosive effect on mucous membranes and may cause scarring of the esophagus. It is corrosive to eye tissue and may cause permanent corneal opacity and conjunctival scarring (Weiss 1980, p. 443). Severe exposure may result in overwhelming pulmonary edema. Renal damage has been described (Gosselin 1984, p. H-207). Hemorrhagic congestion of all internal organs has been observed (Clayton and Clayton 1981-82, p. 2674). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 12°F (CC) (NFPA 1984, p. 325M-51) Flammable Limits: LEL: 3.6% (NFPA 1984, p. 325M-51) UEL: 46% (NFPA 1984, p. 325M-51) Extinguishing Methods: Dry chemical, alcohol foam, or carbon dioxide are useful for small fires. For large fires: water spray, fog or foam (DOT 1984, Guide 30). Special Fire Fighting Procedures: Do not extinguish fire unless flow can be stopped; use water in flooding quantities as a fog. Solid streams of water may be ineffective. Apply water from as far a distance as possible (Student 1981, p. 236). If tank car or truck is involved in fire, isolate the surrounding area in a 1/2 mile radius (DOT 1984, Guide 30). ------- CAS Registry Number: 151-56-4 Page 3 of 4 ETHYLENEIMINE SECTION IV (continued) Unusual Fire and Explosion Hazards: Irritating vapors are generated when heated. Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back. May polymerize in fires with evolution of heat and container rupture (Weiss 1980, p. 443). Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 30). Ethyleneimine vapors are not inhibited and may form polymers in vents or flame arresters, r , alting in stopping of the vents (*NFPA 1978). NFPA Flammabilu; Rating: 3 SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (Weiss 1980, p. 443) Conditions to Avoid: If heated under pressure, instability may result (Weiss 1980, p. 443). Incompatibility (Materials to Avoid): Acids (Weiss 1980, p. 443); sodium hypochlorite (*Bretherick 1979). Hazardous Decomposition or Byproducts: Toxic oxides of nitrogen are produced during combustion (Student 1981, p. 236). Upon treatment with sodium hypochlorite, it gives off the explosive compound 1-chloroazidine (*Bretherick 1979). Hazardous Polymerization: May Occur: Yes (Merck 1983, p. 551) May Not Occur: Conditions to Avoid: Avoid contact with silver or aluminum. Explosive polymerization may occur upon contact with acids (Weiss 1980, p. 443). Polymerization is catalyzed by carbon dioxide (*Bretherick 1979). SECTION VI - USE INFORMATION Products of polymerization of ethyleneimine are used in the paper industry and as flocculation aids (*Encyc Occupat Health and Safety 1971). Used in textile chemicals, adhesives, binders, petroleum refining chemicals, fuels and lubricants, coating resins, varnishes, lacquers, agricultural chemicals, cosmetics, ion exchange resins, photographic chemicals and surfactants (*Clayton and Clayton 1981-82). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of ------- C .5 Registry Number: 151-56-4 I age 4 of 4 ETHYLENEIMINE SECTION VII (continued) water or soap and water (Student 1981, p. 237). ^Keep unnecessary people away, isolate hazard area and deny entry. Stay upwind, keep out of low areas (DOT 1984, Guide 30). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/LIMITED Neoprene POOR/MANY *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms include tearing and burning of the eyes, sore throat, nausea, vomiting, coughing (may persist for weeks or months) and a slow healing dermatitis due to severe blistering (Gosselin 1984, p. 11-207; Weiss 1980, p. 443). Emergency and First Aid Procedures: Move victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact with ethyleneimine, immediately flush skin or eyes with running water for at least 15 minutes (DOT 1984, Guide 30). ------- CAS Registry Number: 152-16-9 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- DIPHOSPHORAMIDE, OCTAMETHYL- CAS Registry Number: 152-16-9 Synonyms: Pyrophosphoramide, Octamethyl-; Bis(bisdimethylaminophosphonous) anhydride; Bis(dimethylamino)phosphoric anhydride; Bis-N,N,N',N'-tetramethyl- phosphorodiamidic anhydride; Lethalaire G-59; Octamethyl pyrophosphortetramide; Octamethyl tetramido pyrophosphate; Octamethyldiphosphoramide; Octamethyl- pyrophosphoramide; Octamethylpyrophosphoric acid tetramide; OMPA; Ompacide; Ompatox; Ompax; Pestox III; Schradan; Pyrophosphoric acid octamethyltetraamide; Pyrophosphoryltetrakisdimethylamide; Scharadan; Systam; Systophos; Sytam; Tetrakisdimethylaminophosphonous anhydride Chemical Formula: C8H24N4P2OS Molecular Weight: 286.26 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDSO oral (rat) 5 mg/kg (*NIOSH/RTECS 1985) TPQ: 100 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 248-257°F, 120-125°C at 0.5 mmHg (*Merck 1976) Specific Gravity (H2O=1): 1.09 at 25°C/4°C (*Merck 1976) Vapor Pressure (mmHg): 0.001 at 25°C (*Worthing 1979) Melting Point: 57-68°F, 14-20°C (*Worthing 1979) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Miscible (*Merck 1976) ------- CAS Registry Number: 152-16-9 Page 2 of 4 DIPHOSPHORAMIDE, OCTAMETHYL- SECTION II (continued) Appearance and Odor: Viscous liquid (*Merck 1976); dark brown viscous liquid (*Worthing 1979). SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Maximum permissible atmospheric concentration of this compound in work places is estimated to be 0.5 mg/ms (*Clarke 1975). Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and Safety 1971) Skin: Yes (*Sax 1975) Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): Extremely toxic; probable oral lethal dose in humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for a 150 Ib. person (*Gosselin 1976). It is highly toxic when inhaled (*Encyc Occupat Health and Safety 1971). Material is a cholinesterase inhibitor (*Hayes, 1975). It is similar in action to other organophosphorous pesticides in its toxicity. It is slightly less toxic than parathion (*Gosselin 1976). Gastrointestinal, neurologic and respiratory symptoms may accompany poisoning with this material. High doses may cause a toxic psychosis similar to acute alcoholism (*Rumack 1975 to Present). Medical Conditions Generally Aggravated by Exposure: Persons taking phenobarbital and phenaglycodol together, glutethimide, chlorpromazine hydrochloride, or meprobamate may be at greater risk. These drugs appear to enhance the toxicity of the material markedly (*Kato 1967). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific -- Organophosphorus Liquid Pesticides) Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, carbon dioxide, or dry chemical (*Student 1981). Special Fire Fighting Procedures: Not Found ------- CAS Registry Number: 152-16-9 Page 3 of 4 DIPHOSPHORAMIDE, OCTAMETHYL- SECTION IV (continued) Unusual Fire and Explosion Hazards: When heated to decomposition, it can emit highly toxic fumes of oxides of phosphorus (*Sax 1979). NFPA Flammability Rating: Not Found SECTION V ~ REACTIVITY DATA Stability: Unstable: Stable: Yes (*Worthing 1979) Conditions to Avoid: Hydrolyzed under acid conditions to dimethylamine and orthophosphoric acid (*Worthing 1979) Incompatibility (Materials to Avoid): Decomposes when mixed with acid (*Worthing 1979). Hazardous Decomposition or Byproducts: Decomposes when mixed with acid (*Worthing 1979). Emits highly toxic fumes of oxides of phosphorous when heated to decomposition (*Sax 1979). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI ~ USE INFORMATION Material is used as a systemic insecticide for plants and as an acaricide (*Merck 1976). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Organophosphorus Liquid Pesticides) Use water spray to knock down vapors. Attempt to stop leak if it can be done without hazard. Avoid breathing vapors. Keep upwind. Avoid bodily contact with material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water (*Student 1981). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 152-16-9 Page 4 of 4 DIPHOSPHORAMIDE, OCTAMETHYL- SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 152-16-9 Page 1 of 3 Emergency First Aid Treatment Guide for DIPHOSPHORAMIDE, OCTAMETHYL- (152-16-9) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Viscous liquid. Commercial Form - Dark brown viscous liquid (technical grade). Use - Pesticide. Caution: Avoid sources of extreme heat including fire. Di phosphor amide, octamethyl- will liberate toxic phosphorus oxides when heated to decomposition. Other Names - OMPA, Omapacide, Ompatox, Ompax, Pestox III, Schradan, Systam, Systophos, Sytam. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Diphosphoramide, Octamethyl- [OMPA] Exposure: Note: Octamethyl diphosphoramide is a cholinesterase inhibitor. Acute exposure to OMPA may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) and chest pain may be noted. Hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea, respiratory depression, and respiratory paralysis. Psychosis may occur. ------- EFATG CAS Registry Number: 152-16-9 Page 2 of 3 DIPHOSPHORAMIDE, OCTAMETHYL- Emergency Life-Support Procedures: Acute exposure to OMPA may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to OMPA. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to OMPA. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 152-16-9 Page 3 of 3 DIPHOSPHORAMIDE, OCTAMETHYL- Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of OMPA is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of OMPA may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 297-78-9 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - ISOBENZAN CAS Registry Number: 297-78-9 Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 697) 4,7-Methanoisobenzofuran, l,3,4,5,6,7,8,8-Octachloro-l,3,3a,4,7,7a-Hexahydro-; CP 14,957; ENT 25,545; ENT 25,545-X; l,3,4,5,6,7,8,8-Octachloro-l,3,3a,4,7,7a- hexahydro-4,7-methanoisobenzofuran; 1,3,4,5,6,7,8,8-Octachloro-2-oxa-3a,4,7,7a- tetrahydro-4,7-methanoindene; 1,3,4,5,6,7,10,10-Octachloro-4,7-endo-methylene- 4,7,8,9-tetrahydrophthalan; Omtan; SD 4402; Shell 4402; Shell WL 1650; Telodrin; WL 1650 Chemical Formula: C9H4C18O Molecular Weight: 411.73 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD60 oral (dog) 1 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II ~ PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 1.87 (Hayes 1982, p. 251)' Vapor Pressure (mmHg): 0.00001 at 77°F, 25°C (Hayes 1982, p. 251) Melting Point: 248-252°F, 120-122°C (Merck 1983, pp. 738-739) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (Hayes 1982, p. 251) ------- CAS Registry Number: 297-78-9 Page 2 of 4 ISOBENZAN SECTION II (continued) Appearance and Odor: Crystals (Merck 1983, pp. 738-739). The technical product is a whitish to light-brown crystalline powder with a mild chemical odor (Hayes 1982, p. 251) SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Hayes 1982, p. 251) Skin: Yes (Hayes 1982, p. 251) Ingestion: Yes (Hayes 1982, p. 251) Health Hazards (Acute, Delayed, and Chronic): This material is highly toxic. It is absorbed by the skin as well as by the respiratory and gastrointestinal tract. Symptoms may last for a long time because the material is eliminated slowly; its half-life in human blood is 2.77 years (Hayes 1982, p. 251). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: Non-flammable and non-explosive (Hayes 1982, p. 251) LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific -- Dry Insecticide) Use agent suitable for type of surrounding fire. Use water in flooding quantities as fog. Use alcohol foam, carbon dioxide, or dry chemical (Student 1981, p. 290). Special Fire Fighting Procedures: (Non-Specific — Dry Insecticide) Avoid breathing dusts and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Wear full protective clothing including boots, protective gloves, goggles, and wear self-contained breathing apparatus (Student 1981, p.290). Unusual Fire and Explosion Hazards: Chlorine is evolved when this material is heated above 410°F, 210°C (Hayes 1982, 251). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 297-78-9 Page 3 of 4 ISOBENZAN SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Acids, certain metal salts, and catalytically active carriers (Hayes 1982, p. 251) Hazardous Decomposition or Byproducts: Chlorine is evolved if material is heated above 410°F, 210°C (Hayes 1982, p. 251). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION This material is used as an insecticide (Merck 1983, pp. 738-739). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Dry Insecticide) Keep upwind. Avoid bodily contact with the material (Student 1981, p. 290). (Non-Specific -- Insecticide, Dry, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/LIMITED** Butyl/Neoprene POOR/LIMITED** PVC POOR/LIMITED** ------- -S Registry Number: 297-78-9 1 v.ge 4 of 4 ISOBENZAN SECTION VIII (continued) Viton POOR/LIMITED** Viton/Neoprene POOR/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms of exposure include headache, dizziness, drowsiness, irritability, and numbness of the legs. Convulsions may occur (Hayes 1982, p. 251). Emergency and First Aid Procedures: (Non-Specific -- Insecticide, Dry, n.o.s.) Move victim to fresh air; call emergency medical care. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes (DOT 1984, Guide 53). ------- CAS Registry Number: 297-97-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- THIONAZIN CAS Registry Number: 297-97-2 Synonyms: Phosphorothioic Acid, O,O-Diethyl O-Pyrazinyl Ester; AC 18133; ACC 18133; American Cyanamid 18133; CL 18133; Cynem; O,O-Diethyl O-2-Pyrazinyl Phosphorothioate; Diethyl O-2-Pyrazinyl Phosphorothionate; O,O-Diethyl O-2-Pyrazinyl Phosphothionate; O,0-Diethyl O-Pyrazinyl Thiophosphate; EN 18133; ENT 26,680; Ethyl Pyrazinyl Phosphorothioate; Experimental Nematocide 18,133; Nemafos; Nemaphos; Nematocide; Phosphorothioic Acid, O,O-Diethyl O-2-Pyrazinyl Ester; Pyrazinol, O-Ester with O,O-Diethyl Phosphorothioate; Zinophos Chemical Formula: C8H1SN2O3PS Molecular Weight: 248.26 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 3.5 mg/kg (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II « PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 176°F, 80°C at 0.001 mmHg (Hawley 1981, p. 1019) Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): 0.003 at 30°C (Merck 1983, p. 1338) Melting Point: 29°F, -1.7°C (Hawley 1981, p. 1019) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Slightly soluble (Hawley 1981, p. 1019), 1140 ppm at 24.8°C (*Spencer 1982) ------- CAS Registry Number: 297-97-2 ! age 2 of 4 THIONAZIN SECTION II (continued) Appearance and Odor: Amber liquid (Hawley 1981, p. 1019); pure compound is almost colorless liquid and technical product is light brown to tan mobile liquid (*Spencer 1982) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1019) Skin: Yes (Hawley 1981, p. 1019) Ingestion: Yes (Hawley 1981, p. 1019) Health Hazards (Acute, Delayed, and Chronic): Cholinesterase inhibitor (Hawley 1981, p. 1019). (Non-Specific — Organic Phosphate Compound, Liquid, Poison B). Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes (DOT 1984, Guide 55). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific ~ Organic Phosphate Compound, Liquid, Poison B). Extinguish with dry chemical, carbon dioxide, water spray, or foam. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). (Non-Specific -- Parathion) Extinguish fire using agent suitable for type of surrounding fire. Use water in flooding quantities as fog. Use foam, carbon dioxide, or dry chemicals (Student 1981, p. 392). Special Fire Fighting Procedures: (Non-Specific — Organic Phosphate Compound, Liquid, Poison B). Keep unnecessary people away; stay upwind; wear positive pressure breathing apparatus and special protective clothing; remove and isolate contaminated clothing (DOT 1984, Guide 55). (Non-Specific -- Organic Phosphate Mixture, Liquid, Poison B). Do not extinguish fire unless flow can be stopped (Student 1981, p. 392). (Non-Specific -- Parathion) Avoid breathing dusts, and fumes from burning materials. Avoid body contact with materials. Wear full protective clothing (Student 1981, p. 392). ------- CAS Registry Number: 297-97-2 Page 3 of 4 THIONAZIN SECTION IV (continued) Unusual Fire and Explosion Hazards: (Non-Specific — Organic Phosphate Compound, Liquid, Poison B). This material may burn but does not ignite readily (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: (Non-Specific -- Organic Phosphate Compound, Liquid, Poison B). Fire may produce irritating or poisonous gases (DOT 1984, Guide 55). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI ~ USE INFORMATION It is used in insecticides, fungicides, and nematocides (Hawley 1981, p. 1019). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Organic Phosphate Compound, Liquid, Poison B). Do not touch spilled material; stop leak if possible; use water spray to reduce vapors. Small spill: take up with sand or other noncombustible absorbent material and place into container for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). (Non-Specific ~ Parathion) Avoid breathing vapors. Avoid bodily contact with materials. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water (Student 1981, p. 392). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, ------- CAS Registry Number: 297-97-2 Page 4 of 4 THIONAZIN SECTION VIII (continued) chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: (Non-Specific — Parathion). Acute effects include loss of appetite, nausea, vomiting, diarrhea, excessive salivation, pupillary constriction, bronchoconstriction, muscle twitching, convulsions, and coma (Merck 1983, p. 1010). Emergency and First Aid Procedures: (Non-Specific -- Organic Phosphate Compound, Liquid, Poison B). Move victim to fresh air; call emergency medical care. If not breathing give artificial respiration; if breathing is difficult give oxygen. "In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes; speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site (DOT 1984, Guide 55). (Non-Specific -- Organic Phosphate Mixture, Liquid, Poison B). Wash away any material which may have contacted the body with copious amounts of water or soap and water (Student 1981, p. 381). COMMENTS: Sources searched and no information found: Hayes 1982 Weast 1979 Sax 1984 Clayton and Clayton 1981-82 NFPA 1984 NIOSH/OSHA 1978 ------- CAS Registry Number: 298-00-0 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PARATHION-METHYL CAS Registry Number: 298-00-0 Synonyms: Phosphorothioic Acid, O,O-Dimethyl O-(p-Nitrophenyl) Ester (Dry Mixture); Methyl Parathion; Azofos; Azophos; BAY 11405; Bladan-M; Dalf; Dimethylfenitrothion; Dimethyl 4-Nitrophenyl Phosphorothionate; Dimethyl p-Nitrophenyl Phosphorothionate; Dimethyl p-Nitrophenyl Thiophosphate; Dimethyl Parathion; E 601; ENT 17,292; Folidol M; Folidol M-40; Gearphos; M-Parathion; Meptox; Metacid 50; Metacide; Metafos; Metafos (Pesticide); Metaphos; Methyl-E 605; Methylthiophos; Metron; Metron (Pesticide); NCI-C02971; Nitrox; Nitrox 80; O,O-Dimethyl O-(p-Nitrophenyl) Phosphorothioate; O,O-Dimethyl O-(p-Nitrophenyl) Thionophosphate; O,O-Dimethyl O-(p-Nitrophenyl) Thiophosphate; Oleovofotox; Parathion Methyl Homolog; Partron M; Penncap M; Penncap MLS; Phenol, p-Nitro-, O-Ester with O,O-Dimethyl Phosphorothioate; Phosphorothioic Acid, O,O-Dimethyl O-(4-Nitrophenyl) Ester; Quinophos; Sinafid M-48; Thiophenit; Vofatox; Wofatox; Wofotox; 8056 HC Chemical Formula: C8H10NO5PS Molecular Weight: 263.23 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.034 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 100 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 1.358 at 20°C (*Merck 1983) Vapor Pressure (mmHg): 0.0000097 at 20°C (*Worthing 1979) Melting Point: 99-100°F, 37-38°C (*Merck 1983) ------- CAS Registry Number: 298-00-0 Page 2 of 4 PARATHION-METHYL SECTION II (continue:;) Vapor Density (Air.=l): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 50 mg/liter (*Merck 1983) Appearance and Odor: White crystalline solid or powder (*NFPA 1978); odor like rotten eggs or garlic ("CHRIS 1978). Commercial product is a liquid consisting of 80 percent methyl parathion and 20 percent xylene (NFPA 1984, pp. 49-64); light to dark tan ("Worthing 1979). SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: TWA 0.2 mg/m8 (skin) (ACGIH 1986-7, p.24) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*DOT 1984) Skin: Yes (*DOT 1984) Ingestion: Yes (*DOT 1984) Health Hazards (Acute, Delayed, and Chronic): This material is extremely toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person (*Gosselin 1984). Chronic toxicity does not appear to be a major consideration (*NRC 1977). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not flammable at normal temperatures ("Clayton and Clayton 1982); commercial product, containing xylene, has flashpoint of 115°F (OC) (NFPA 1984, pp. 49-64). Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam (*DOT 1984). Special Fire Fighting Procedures: Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material ("DOT 1984). Wear special protective clothing ("NFPA 1978). Unusual Fire and Explosion Hazards: Poisonous gases are produced in fire and when heated ("CHRIS 1978). Decomposition may lead to sufficient ------- CAS Registry Number: 298-00-0 Page 3 of 4 PARATHION-METHYL SECTION IV (continued) internal pressure to cause the container to rupture violently (NFPA 1984, pp. 49-64). NFPA Flammability Rating: 1 (solid); 3 (xylene solution) SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*NFPA 1978) Stable: Conditions to Avoid: High temperatures (120°F) cause decomposition (NFPA 1984, pp. 49-64). Incompatibility (Materials to Avoid): Oxidizing materials (NFPA 1984, pp. 49-64). Hazardous Decomposition or Byproducts: Decomposition may lead to rupture of containers (NFPA 1984, pp. 49-64). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION This material is used as an insecticide on over 50 crops, primarily cotton, and on several ornamentals (*SRI). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other non-combustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry containers and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- C \S Registry Number: 298-00-0 I age 4 of 4 PARATHION-METHYL SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 298-00-0 Page 1 of 3 Emergency First Aid Treatment Guide for PARATHION-METHYL (298-00-0) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - White crystalline solid or powder. Odor - Resembling rotten eggs or garlic. Commercial Forms - Emulsifiable concentrates, wettable powders, dusts, or light to dark tan liquid consisting of 80% parathion-methyl and 20% xylene. Use - Insecticide. Materials to Avoid - Oxidizers. Other Names - Dalf; Dimethyl parathion; ENT-17,292; Folidol-M; Meptox; Metacide; Metaphos; Metron; Nitrox; Partron M; Penncap M; phosphorothioic acid, O,O-dimethyl O-(p-nitrophenyl)ester; Quinophos; Thiophenit; Vofatox; Wofatox. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Parathion-Methyl Exposure: Note: Parathion-methyl is a cholinesterase inhibitor. Acute exposure to parathion-methyl may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) may occur although hypertension (high blood pressure) is not uncommon. Chest pain may be noted. Respiratory symptoms include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur. ------- i-FATG CAS Registry Number: 298-00-0 Page 2 of 3 PARATHION-METHYL Emergency Life-Support Procedures: Acute exposure to parathion-methyl may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to parathion-methyl. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to parathion-methyl. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 298-00-0 Page 3 of 3 PARATHION-METHYL Ingestion Exposure: J. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of parathion-methyl is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of parathion-methyl may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 298-02-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PHORATE CAS Registry Number: 298-02-2 Synonyms: Phosphorodithioic Acid, O,O-Diethyl S-(EthyIthio)MethyI Ester; Methanethiol, (Ethylthio)-, S-Ester with O,O-Diethylphosphorodithioate; O,O-Diethyl S-Ethylmercaptomethyl Dithiophosphonate; O,O-Diethyl S-Ethylthiomethyl Dithiophosphonate; O,O-Diethyl S-(Ethylthio)methyl Dithiophosphonate; Experimental Insecticide 3911; L 11/6; Thimet; American Cyanamid 3,911; AC 3911; American Cyanamid 3911; El 3911; ENT 24,042, ENT 24042; Granutox; O,O-Diethyl Ethylthiomethyl Phosphorodithioate; O,O-Diethyl S-Ethylmercaptomethyl Dithiophosphate; O,O-Diethyl S-Ethylthiomethyl Thiothionophosphate; Phorate 10G; Rampart; Thimet 10G; Timet; Vegfru; Vergfru Foratox; VUAgT 182 Chemical Formula: C7H17O2PS3 Molecular Weight: 260.39 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.011 mg/liter for 1 hour (*NIOSH/RTECS 1985) TPQ: 10 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 257-261°F, 125-127°C at 2 mmHg (*Merck 1983) Specific Gravity (H2O=1): 1.156 at 25°C (*Merck 1983) Vapor Pressure (mmHg): 0.00084 at 20°C (*Merck 1983) Melting Point: -45°F, -42.9°C (*Spencer 1982) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found ------- CAS Registry Number: 298-02-2 Page 2 of 4 PHORATE SECTION II (continued) Solubility in Water: 50 mg/liter (*Merck 1983) Appearance and Odor: Clear liquid (*Merck 1983); objectionable odor (*Osol 1980) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: TWA 0.05 mg/ms (skin); STEL 0.2 mg/ms (skin) (*ACGIH 1983) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*ACGIH 1980) Skin: Yes (*ACGIH 1980) Ingestion: Yes (*ACGIH 1980) Health Hazards (Acute, Delayed, and Chronic): This material is one of the more toxic organophosphorus insecticides (*Osol 1980). It is a cholinesterase inhibitor that acts on the nervous system, and produces toxicity similar to Parathion. The probable oral lethal dose for humans is less than 5 mg/kg, i.e. a taste (less than 7 drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific - Orgahophosphorous Pesticide) Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 55) Special Fire Fighting Procedures: (Non-Specific -- Organophosphorous Pesticide) Wear positive pressure self-contained breathing apparatus. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: Shock can shatter containers, releasing the contents. When heated to decomposition, toxic fumes of sulfur oxides, phosphorus oxides, and nitrogen oyi:; ^ emitted (Sax 1984, p. 2208). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 298-02-2 Page 3 of 4 PHORATE SECTION V ~ REACTIVITY DATA Stability: Unstable: Stable: Yes (*Merck 1983) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Hydrolyzed in water and alkalies (*Merck 1983). Hazardous Decomposition or Byproducts: When heated to decomposition, sulfur oxides, phosphorus oxides, and nitrogen oxides are emitted (Sax 1984, p. 2208) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI ~ USE INFORMATION This material is used as an insecticide and acaricide; it is applied to plants and soil (*SRI). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Organophosphorus Pesticide) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical aftalog. ------- CAS Registry Number: 298-02-2 Page 4 of 4 PRORATE SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 298-02-2 Page 1 of 3 Emergency First Aid Treatment Guide for PRORATE (298-02-2) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Clear liquid. Odor - Objectionable. Commercial Forms - 2.5, 5, 10, and 20% pure granules. Use - Pesticide. Caution: Phorate will form toxic mixtures of sulfur oxides, phosphorus oxides, and nitrogen oxides when heated to decomposition. Avoid sources of extreme heat. Other Names - American Cyanamid 3911, Granutox, Rampart, Thimenox, Thimet, Vegfru, O,O-diethyl S-ethylmercaptomethyl dithiophosphonate. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Phorate Exposure: Note: Phorate is a cholinesterase inhibitor. Acute exposure to phorate may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may occur, although hypertension (high blood pressure) is not uncommon. Dyspnea (shortness of breath) may be followed by respiratory collapse. Giddiness is common. ------- EFATG CAS Registry Number: 298-02-2 Page 2 of 3 PRORATE Emergency Life-Support Procedures: Acute exposure to phorate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to phorate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to phorate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5, Wash exposed skin areas three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 298-02-2 Page 3 of 3 PHORATE Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of phorate is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of phorate may result in .sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 298-04-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- DISULFOTON CAS Registry Number: 298-04-4 Synonyms: Phosphorodithioic Acid, O,O-Diethyl S-(2-(Ethylthio)Ethyl) Ester; Bay 19639; Bayer 19639; Di-syston; Di-syston G; Dimaz; Disulfaton; Disystox; Dithiodemeton; Dithiosystox; Dution; Ekatin TD; ENT 23,437; ENT-23437; Ethyl Thiometon; Ethylthiometon B; Frumin; Frumin AL; Frumin G; Glebofos; M 74 (Pesticide); M-74; 0,O-Diethyl 2-Ethylthioethyl Phosphorodithioate; O,O-Diethyl S-(2-(Ethylthio)Ethyl) Phosphorodithioate; O,O-Diethyl S-(2-Eththioethyl) Phosphorodithioate; O,O-Diethyl S-(2-Eththioethyl)Thiothionophosphate; O,O-Diethyl S-(2-Ethylmercaptoethyl) Dithiophosphate; O,O-Diethyl S-2-(Ethylthio)Ethyl Phosphorodithioate; O,O-Ethyl S-2(Ethylthio)Ethyl Phosphorodithioate; Phosphorodithioic Acid, O,O-Diethyl S-(2-(Ethylthio)Ethyl) Ester; Phosphorodithionic Acid, S-2-(Ethylthio)Ethyl O,O-Diethyl Ester; S 276; S-2-(Ethylthio)Ethyl O,O-DiethyI Ester of Phosphorodithioic Acid; Solvirex; Thiodemeton; Thiodemetron; Vuagt 1-4; Vuagt 1964 Chemical Formula: C8H19O2PS3 Molecular Weight: 274.38 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDBO oral (rat) 2 mg/kg (*NIOSH/RTECS 1985). TPQ: 500 (pounds) RQ: 1 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 270-271°F, 132-133°C at 1.5 mmHg (*Merck 1976) Specific Gravity (H2O=1): 1.144 (*Merck 1976) Vapor Pressure (mmHg): 0.00018 at 20°C (*Spencer 1973) Melting Point: Greater than -13°F, -25°C (*Sunshine 1969) ------- >S Registry Number: 298-04-4 ge 2 of 4 SECTION II (continued) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 25 mg/liter at 23°C (*NRC 1977) Appearance and Odor: Oily, colorless liquid when pure; technical product is dark yellowish oil (*Spencer 1973). It has a characteristic sulfur odor (*Sax 1975). SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: TWA 0.1 mg/ms (ACGIH 1986-7, p.18) IDLH: Not Found Other Limits Recommended: An airborne limit of 0.1 mg/ms should serve to limit general room contamination (* ACGIH 1980). Routes of Entry: Inhalation: Yes (*DOT 1984) Skin: Yes (*DOT 1984) Ingestion: Yes (*DOT 1984) Health Hazards (Acute, Delayed, and Chronic): It is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). It is poisonous and may be fatal if inhaled, swallowed, or absorbed through the skin. Contact may cause burns to skin and eyes (*DOT 1984). Medical Conditions Generally Aggravated by Exposure: Not found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Wear positive pressure breathing apparatus and special protective clothing (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: Material nu but does not ignite easily. Cylinder may explode in the heat of fire ~ous gases may be generated from the fire or runoff water (DOT I •„ ide 55). ------- CAS Registry Number: 298-04-4 Page 3 of 4 DISULFOTON SECTION IV (continued) NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Oxidizable in air (*Sunshine 1969). Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated poisonous gases may be given off (DOT 1984, Guide 55). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Major uses include insecticide for mites and aphids on small grains, corn, sorghum, cotton, and other field crops, fruits, nuts, and ornamentals (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spill material. Exposure by skin contact is likely to be more significant than inhalation (*ACGIH 1980). Small spills: take up with sand or other noncombustible absorbent materials and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 298-04-4 Page 4 of 4 DISULFOTuN SECTION VIII (continued) SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 298-04-4 Page 1 of 3 Emergency First Aid Treatment Guide for DISULFOTON (298-04-4) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Form - Oily brown, yellow, or colorless liquid. Odor - Pure compound has characteristic sulfur .odor, commercial form has aromatic odor. Commercial Forms - Granules, powder, emulsifiable concentrate, dark yellow oil. Use - Pesticide. Caution: Containers may explode when exposed to high temperatures. Toxic gases may be liberated. Avoid sources of extreme heat. Other Names - Di-syston, disystox, Dithiosystox, Dution, Frumin, Glebofos, Solvirex, Thiodemeton, O,O-diethyl S-2-(ethylthio)ethyl phosphorodithioate. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, pralidoxime, diazepam, phenytoin, phenobarbital. Signs and Symptoms of Acute Disulfoton Exposure: Note: Disulfoton is a cholinesterase inhibitor. Acute exposure to disulfoton may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) and chest pain may be noted. Hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur. ------- EFATG CAS Registry Number: 298-04-4 Page 2 of 3 DISULFOTON Emergency Life-Support Procedures: Acute exposure to disulfoton may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to disulfoton. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to disulfoton. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 298-04-4 Page 3 of 3 DISULFOTON Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of disulfoton is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of disulfoton may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 300-62-9 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- AMPHETAMINE CAS Registry Number: 300-62-9 Synonyms: Phenethylamine, alpha-Methyl; (+-)-alpha-Methylbenzene- ethanamine; (+-)-alpha-Methyl Phenethylamine; (+-)-alpha-Methylphenyl ethylamine; (+-)-beta-Phenylisopropylamine; (+-)-Desoxynorephedrine; (Phenylisopropyl)amine; l-Phenyl-2-aminopropane; Acetedron; Adipan; Allodene; Anorexide; Anorexine; Benzebar; Benzedrine; Benzeneethanamine, alpha-Methyl-, (+-); Benzolone; beta-Aminopropylbenzene; DL-l-Phenyl-2-Aminopropane; DL-alpha-Methylphenethylamine; DL-Amphetamine; DL-Benzedrine; Elastonon; Finam; Isoamyne; Isomyn; Mecodrin; Norephedrane; Norephedrine, deoxy-; Novydrine; Oktedrin; Ortedrine; Percomon; Phenedrine; Profamina; Propisamine; Psychedrine; Racemic desoxy-nor-ephedrine; Raphetamine; Rhinalator; Simpatedrin; Simpatina; Sympamine; Sympatedrine; Weckamine Chemical Formula: C9H1SN Molecular Weight: 135.20 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mouse) 22mg/kg (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 392-397°F, 200-203°C (*Merck 1976) Specific Gravity (H2O=1): 0.913 at 25°C/4°C (*Merck 1976) Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): 4.65 (Sax 1984, p. 271) ------- CAS Registry Number: 300-62-9 Page 2 of 4 AMPHETAMINE SECTION II (continued) Evaporation Rate (Butyl acetate=l): Evaporates slowly at room temperature (*Merck 1976). Solubility in Water: Slightly soluble (*Merck 1976). Appearance and Odor: Colored liquid; amine odor (*Merck 1976). SECTION III ~ HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Not Found Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): It is classified as extremely hazardous. Probable lethal dose in humans is 5-50 mg/kg or 7 drops to 1 teaspoon for a 70 kg (150 Ib.) person (*Gosselin 1976). Habit forming drug which affects the central nervous system (Hawley 1981, p. 65). Medical Conditions Generally Aggravated by Exposure: Excessive use may lead to tolerance and physical dependence (*Merck 1976). Death is possible (Gosselin 1976, p. 11-369). SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 80°F, 26.6°C (no method given) (Hawley 1981, p. 65) Flammable Limits: It is flammable (Hawley 1981, p. 65) LEL: Not Found UEL: Not Found Extinguishing Methods: Extinguish with carbon dioxide or dry chemical (*Sax 1975). Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Dangerous when exposed to heat or flames (*Sax 1975). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 300-62-9 Page 3 of 4 AMPHETAMINE SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Can react with oxidizing materials (*Sax 1975). Hazardous Decomposition or Byproducts: Upon decomposition, nitrogen oxides are emitted (*Sax 1975). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Amphetamine is used as a pharmaceutical (Hawley 1981, p. 65). It is a central nervous system stimulant (*Rossoff 1974). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Drugs, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Shut off ignition sources; no flares, smoking or flames in hazard area. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch spilled material. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 11). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Nitrile GOOD/LIMITED** Viton/Neoprene POOR/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 300-62-9 Page 4 of 4 AMPHETAMINE SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Dry mouth, metallic taste, loss of appetite, nausea, vomiting, diarrhea, abdominal cramps, headache, chilliness, flushing or pallor, palpitation, restlessness, dizziness, tremor, hyperactive reflexes, talkativeness, tenseness, irritability, weakness, insomnia, fever, confusion. With large doses, irregular heartbeat, pain and difficulty in urination (*Goodman 1975). Convulsions, coma, circulatory collapse (Gosselin 1976, p. H-369). Emergency and First Aid Procedures: (Non-Specific — Drugs, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature (DOT 1984, Guide 11). ------- CAS Registry Number: 302-01-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- HYDRAZINE CAS Registry Number: 302-01-2 Synonyms: Diamine; Hydrazine Anhydrous; Hydrazine Base; Hydrazine, Anhydrous; Levoxine Chemical Formula: H4N2 Molecular Weight: 32.05 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC60 inhalation (mouse) 0.33 mg/Liter/4 hours (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory); 1 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II ~ PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 236.3°F, 113.5°C (*Merck 1983) Specific Gravity (H2O=1): 1.011 at 15°C/4°C (*Merck 1983) Vapor Pressure (mmHg): 14.4 at 25°C (*Sunshine 1969) Melting Point: 36°F, 2.0°C (*Merck 1983) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Miscible (*Merck 1983) Appearance and Odor: Colorless, oily liquid with penetrating ammonia-like odor (*Merck 1983). ------- CAS Registry Number: 302-01-2 Page 2 of 4 HYDRAZINE SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 1 ppm (1.3 mg/m3) (NIOSH 1987, p.136) ACGIH TLV: TWA 0.1 ppm (0.1 mg/ms) (skin) (ACGIH 1986-87, p.20) IDLH: 80 ppm (*Encyc Occupat Health and Safety 1983) Other Limits Recommended: Short-term inhalation limits - 1 ppm for 30 minutes (Weiss 1980, p. 509); Occupational Exposure to Hydrazines Recommended Standard Air Ceiling 0.04 mg/ms/2 hours (*NIOSH/RTECS 1985). Industrial Substance Suspect of Carcinogenic Potential for Humans -- Recommended TLV 0.1 ppm (skin) (ACGIH 1984, p. 42). NIOSH: 0.04 mg/ms 120-minute ceiling (NIOSH 1987, p.136). SPEGL 0.12 ppm (60 minutes) (NRC I985b, pp. 5-22). Routes of Entry: Inhalation: Yes (NIOSH/OSHA 1978, p. 110) Skin: Yes (NIOSH/OSHA 1978, p. 110) Ingestion: Yes (NIOSH/OSHA 1978, p. 110) Health Hazards (Acute, Delayed, and Chronic): Target organs affected include central nervous system; respiratory system; skin and eyes (NIOSH/OSHA 1978, p. 110). Chronic exposure in humans may cause pneumonia, liver and kidney damage. Liver damage may be more severe than kidney damage (Gosselin 1976, p. 11-247). It is a suspected human carcinogen (ACGIH 1984, p. 42). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 52°C (*Merck 1983) Flammable Limits: LEL: 4.7% (*NFPA 1978) UEL: 100% (*NFPA 1978) Extinguishing Methods: Small fires: dry chemical, carbon dioxide, water spray or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 28). Special Fire Fighting Procedures: Stay upwind; keep out of low areas. Wear positive pressure breathing apparatus and protective clothing. Isolate for one-half mile in all directions if tank car or truck is involved in fire. Move container from fire area if you can do so without risk. Dike fire control water for later disposal; do not scatter material. Spray cooling water on containers that are exposed to flames until well after fire is out (DOT 1984, Guide 28). Unusual Fire and Explosion Hazards: It is a flammable/combustible material and may be ignited by heat, sparks, or flames. Vapor may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion and poison hazard indoc? : : ors, or in sewers. ------- CAS Registry Number: 302-01-2 Page 3 of 4 HYDRAZINE SECTION IV (continued) Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 28). Vapors form explosive mixtures with air (NFPA 1984, pp. 49-52). May continue to burn in the absence of air (*Bretherick 1979). NFPA Flammability Rating: 3 SECTION V -- REACTIVITY DATA Stability: Unstable: Yes (*NFPA 1978) Stable: Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Can catch fire when in contact with porous materials such as wood, asbestos, cloth, earth, and rusty metals (Weiss 1980, p. 509). Incompatible with oxidizers, hydrogen peroxide, nitric acid, metal oxides, and strong acids (NIOSH/OSHA 1978, p. 110). Hazardous Decomposition or Byproducts: Decomposition gives off toxic nitrogen compound fumes (*Rumack 1975 to Present). Hazardous Polymerization: May Occur: May Not Occur: Yes (Weiss 1980, p. 509) Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Chemical intermediate for pesticides, blowing agents, photography chemicals, Pharmaceuticals, antituberculants, textile dyes (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation of vapors (see Section III above). Shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes (DOT 1984, Guide 28). ------- CAS Registry Number: 302-01-2 Page 4 of 4 HYDRAZINE SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED CPE POOR/LIMITED* Chlorobutyl GOOD/LIMITED Neoprene GOOD/LIMITED • Nitrile GOOD/LIMITED PVC GOOD/LIMITED Teflon POOR/LIMITED Viton POOR/LIMITED* *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 302-01-2 Page 1 of 3 Emergency First Aid Treatment Guide for HYDRAZINE (302-01-2) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: Pure Forms - Colorless, fuming, oily liquid. Odor - Penetrating, ammonialike. Commercial Form - 97.5% pure liquid in glass bottles, carboys, stainless steel cans, drums, tank trucks. Uses - Chemical intermediate, antioxidant, heat stabilizer, corrosion inhibitor, nickel plating, chain extender in polymerization, component of rocket fuel, military applications. Materials to Avoid - Porous materials, oxidizers, acids, water (except for use in emergency life support). Caution: Highly flammable and explosive. Avoid sources of extreme heat or ignition including sparks or fire. Other Names - Hydrazine anhydrous, Levoxine. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam, pyridoxine, phenytoin, phenobarbital. Signs and Symptoms of Acute Hydrazine Exposure: Warning: Effects may be delayed for hours to days. Caution is advised. ------- EFATG CAS Registry Number: 302-01-2 Page 2 of 3 HYDRAZINE Signs and symptoms of acute exposure to hydrazine may include severe eye irritation, facial numbness, facial swelling, and increased salivation. Hydrazine vapor may immediately irritate the nose and throat. Headache, twitching, seizures, convulsions, and coma may also occur. Gastrointestinal signs and symptoms include anorexia, nausea, and vomiting. Pulmonary edema and hypotension (low blood pressure) are common. Hydrazine is toxic to the liver, ruptures red blood cells, and may cause kidney damage. Dermal contact may result in irritation or severe burns. Emergency Life-Support Procedures: Acute exposure to hydrazine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to hydrazine. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to hydrazine. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with sr and water. ------- EFATG CAS Registry Number: 302-01-2 Page 3 of 3 HYDRAZINE 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 309-00-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ALDRIN CAS Registry Number: 309-00-2 Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 113) 1,4:5,8- Dimethanonaphthalene, l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-Hexahydro-; Aldrex; Aldrite; Aldrosol; Aldrin, Cast Solid; Aldrin Mixture, Dry; Aldrin Mixture, Liquid; Compound 118; Drinox; ENT 15,949; Hexachlorohexahydro- endo-exo-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a- Hexahydro-l,4,5,8-Dimethanonaphthalene; l,2,3,4,10,lO-Hexachloro-l,4,4a,5,8,8a- Hexahydro-exo-l,4-endo-5,8-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro- l,4,4a,5,8,8a-Hexahydro-l,4-endo-exo-5,8-Dimethanonaphthalene; HHDN; NCI-C00044; Octalene; Seedrin; l,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10- Hexachloro-l,4,4a,5,8,8a-Hexahydro-, (1 alpha, 4 alpha, 4a beta, 5 alpha, 8 alpha, 8a beta)- Chemical Formula: C12H8C16 Molecular Weight: 364.90 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD60 oral (cat) 10 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory); 1 (pounds) (proposed) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: 293°F, 145°C at 2 mmHg (Hayes 1982, p. 234); decomposes (NIOSH/OSHA 1978, p. 42) Specific Gravity (H2O=1): 1.70 at 20°C (Hayes 1982, p. 234) Vapor Pressure (mmHg): 0.000006 at 25°C (Hayes 1982, p. 234) Melting Point: (Pure) 219°F, 104°C; (Technical) 120-140°F, 49-60°C (Hayes 1982, p. 234) ------- CAS Registry Number: 309-00-2 Page 2 of 4 ALDRIN SECTION II (continued) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 0.027 mg/liter (Hayes 1982, p. 234) Appearance and Odor: (Pure) Odorless, white solid. (Technical) Tan to dark brown solid with a mild "chemical" odor (Hayes 1982, p. 234). SECTION III -- HEALTH HAZARD DATA OSHA PEL: 0.25 mg/ms (NIOSH/OSHA 1978, p. 42) ACGIH TLV: 0.25 mg/ms (skin) (ACGIH 1986-87, p. 9) IDLH: 100 mg/m3 (NIOSH/OSHA 1978, p. 42) Other Limits Recommended: NIOSH: Lowest detectable limit (NIOSH 1987, p. 46) Routes of Entry: Inhalation: Yes (NIOSH 1978, p. 42) Skin: Yes (NIOSH 1978, p. 42) Ingestion: Yes (NIOSH 1978, p. 42) Health Hazards (Acute, Delayed, and Chronic): Poisoning by aldrin usually involves convulsions due to its effects on the central nervous system. Reproductive effects and liver effects have also been reported (Doull 1980, p. 383; Hayes 1982, p. 235). It is classified as an extremely toxic chemical. Probable oral lethal dose for humans is between 7 drops and one oz. for a 150 Ib. adult human (Gosselin 1976, p. 186). Conflicting reports of carcinogenicity of this compound remain an area of controversy (Doull 1980, p. 383). Similar chemically and lexicologically to dieldrin (Gosselin 1984, p. 11-285). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Approximately 150°F or higher (no method given) (NFPA 1984, p. 49-13) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Flammable (Hayes 1982, p. 234). Extinguish by using water spray, dry chemical, foam, or carbon dioxide. Use water to keep fire-exposed containers cool. Use water spray to disperse the vapors (NFPA 1984, p. 49-13). ------- CAS Registry Number: 309-00-2 Page 3 of 4 ALDRIN SECTION IV (continued) Special Fire Fighting Procedures: Wear full protective clothing (NFPA 1984, p. 49-13) including positive pressure breathing apparatus. Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits toxic fumes of chlorine containing compounds (Sax 1984, p. 153). Commercial solutions may contain flammable or combustible liquids. The dry powder will not burn (NFPA 1984, p. 49-13). Container may explode in heat of fire (DOT 1984, Guide 55). NFPA Flammability Rating: 1 (solution); 0 (dry) SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Avoid concentrated mineral acids, acid catalysts, acid oxidizing agents, phenols, or active metals (Hayes 1982, p. 234). Hazardous Decomposition or Byproducts: When heated to decomposition it emits toxic fumes of chlorine containing compounds (Sax 1984, p. 153). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Formerly used as an insecticide; manufacture and use have been discontinued in the USA (Merck 1983, p. 36). Registered as a termicide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation (see Section III). Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). ------- CAS Registry Number: 309-00-2 Page 4 of 4 ALDRIN SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl POOR/LIMITED** Butyl/Neoprene POOR/LIMITED** CPE POOR/LIMITED** Neoprene POOR/LIMITED** Nitrile POOR/LIMITED** PE POOR/LIMITED** PVC POOR/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 309-00-2 Page 1 of 3 Emergency First Aid Treatment Guide for ALDRIN (309-00-2) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Substance Characteristics: , Pure Form - Colorless or white crystalline solid. Odor - None (mild chemical odor in commercial form). Commercial Forms - Tan to dark brown emulsifiable concentrate, wettable powders, granules, or dusts in 1- and 5-gaIlon cans or 45-gallon fiber drums. Use - Insecticide. Other Names - Aldrite; Aldrosol; Drinox; HHDN; 1,2,3,4,10,10-hexachloro- l,4,4a,5,8,8a-hexahydro-exo-l,4-endo-5,8-dimethanonaphthalene; Octalene; Seedrin. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, alcohol, syrup of Ipecac, activated charcoal, saline cathartic or sorbitol, D5W, normal saline, Ringer's lactate, diazepam, phenytoin, phenobarbital, thiopental, succinylcholine. Signs and Symptoms of Acute Aldrin Exposure: Signs and symptoms of acute exposure to aldrin may be severe and include headache, dizziness, agitation, nervousness, tremor, seizures, and coma. Convulsive episodes may alternate with periods of severe central nervous system depression. Nausea, vomiting, and diarrhea are common. Hypertension (high blood pressure), tachycardia (rapid heart rate), and cardiac arrhythmias (abnormal heart beating) may be noted. Respiratory depression may lead to respiratory arrest. Contact with the skin, eyes, and mucous membranes may result in redness and irritation. Victims often have an elevated temperature. ------- EFATG CAS Registry Number: 309-00-2 i'age 2 of 3 ALDRIN Emergency Life-Support Procedures: Acute exposure to aldrin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to aldrin. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to aldrin. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas three times. Wash initially with soap and water, follow with an alcohol wash, then again with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. ------- EFATG CAS Registry Number: 309-00-2 Page 3 of 3 ALDRIN Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of aldrin is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of aldrin may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. ------- CAS Registry Number: 315-18-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - MEXACARBATE CAS Registry Number: 315-18-4 Synonyms: Carbamic Acid, Methyl-, 4-Dimethylamino-3,5-xylyl Ester; Zectran; 3,5-Dimethyl-4-(Dimethylamino)Phenyl Methylcarbamate; 3,5-Xylenol, 4-(Dimethylamino)-, Methylcarbamate; 4-(Dimethylamino)-3,5-Xylyl N-Methylcarbamate; 4-(Dimethylamino)-3,5-Dimethylphenol Methylcarbamate (Ester); 4-(Dimethylamino)-3,5-Dimethylphenyl N-Methylcarbamate; 4-(Dimethylamino)-3,5-Xylenol, Methylcarbamate (Ester); 4-(N,N-Dimethylamino)- 3,5-Xylyl N-Methylcarbamate; 4-Dimethylamino-3,5-Dimethylphenyl Methylcarbamate; 4-Dimethylamino-3,5-Dimethylphenyl N-Methylcarbamate; 4-Dimethylamino-3,5-Xylenyl N-Methylcarbamate; 4-Dimethylamino-3,5-Xylyl Methylcarbamate; 4-Dimethylamino-3,5-Xylyl N-Methylcarbamate; Carbamate, 4-Dimethylamino-3,5-Xylyl, N-Methyl-; Carbamic Acid, Methyl-, 4-(Dimethylamino)-3,5-Dimethylphenyl Ester; Carbamic Acid, Methyl-, 4-(Dimethylamino)-3,5-Xylyl Ester; Dowco 139; Dowco-139; ENT 25,766; ENT 25766; ENT-25,766; MAZ; Methyl-4- Dimethylamino-3,5-Xylyl Carbamate; Methyl-4-Dimethylamino-3,5-Xylyl Ester of Carbamic Acid; Methylcarbamic Acid 4-(Dimethylamino)-3,5-Xylyl Ester; Mexicarbate; NCI-C00544; OMS-47; Phenol, 4-(Dimethylamino)-3,5-Dimethyl-, Methylcarbamate (Ester); Zactran; Zectane; Zextran; Phenol, 4-(Dimethylamino)- 3,5-Dimethyl-, Methylcarbamate (Ester) Chemical Formula: C12H18N2O2 Molecular Weight: 222.29 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 14 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1000 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found ------- CAS Registry Number: 315-18-4 Page 2 of 4 MEXACARBATE SECTION II (continued) Vapor Pressure (mmHg): Less than 0.1 at 139°C (*Merck 1983) Melting Point: 185°F, 85°C (*Merck 1983) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 0.01% at 25°C (*Merck 1983) Appearance and Odor: White crystalline solid, odorless (*Martin 1974) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Non-Specific -- Carbamate Pesticide, Solid, n.o.s) (DOT 1984, Guide 55) Skin: Yes (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) (DOT 1984, Guide 55) Ingestion: Yes (*Gosselin 1976) Health Hazards (Acute, Delayed, and Chronic): Extremely toxic: probable oral lethal dose for humans is 5-50 mg/kg; between 7 drops and 1 teaspoonful for 70 kg person (150 Ib.) (*Gosselin 1976). (Non-Specific - Carbamate Pesticide, Solid, n.o.s.) Poisonous; may be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes (DOT 1984, Guide 55). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Special Fire Fighting Procedures: Not Found ------- CAS Registry Number: 315-18-4 Page 3 of 4 MEXACARBATE SECTION IV (continued) Unusual Fire and Explosion Hazards: (Non-Specific — Carbamate Pesticide, Solid, n.o.s.) Fire may produce irritating or poisonous gases. This material may burn but does not ignite readily. Container may explode in heat of fire (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Martin 1974) Conditions to Avoid: Subject to photo-decomposition in the solid state (*IARC 1972-1985). Incompatibility (Materials to Avoid): Decomposition in highly alkaline media (*Martin 1974). Hazardous Decomposition or Byproducts: When heated to decomposition it emits toxic fumes of nitrogen oxides (Sax 1984, p. 1108). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION It is an insecticide for non-agricultural uses, e.g., lawn and turf, flowers, gardens, vines, forest lands, woody shrubs and trees and also a molluscicide. It is not produced commercially in the United States (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific - Carbamate Pesticide) Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewer. Avoid bodily contact with the material (Student 1981, p. 104). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 315-18-4 Page 4 of 4 MEXACARBATE SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms of carbamate poisoning resemble those of parathion. This material is similar to carbaryl; symptoms of carbaryl exposure include nausea, vomiting, abdominal cramps, diarrhea, excessive salivation, sweating, lassitude and weakness. Runny nose and sensation of tightness in chest may occur with inhalation exposures. Blurring or dimness of vision, tearing, eye muscle spasm, loss of muscle coordination, slurring of speech, and twitching of muscles may also occur (*Gosselin 1976). Emergency and First Aid Procedures: (Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 316-42-7 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- EMETINE, DIHYDROCHLORIDE CAS Registry Number: 316-42-7 Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 192) Amebicide; (-)-Emetine Dihydrochloride; 1-Emetine Dihydrochloride; Emetine, Hydrochloride; NSC-33669 Chemical Formula: C29H40N2O4 2HC1 Molecular Weight: 553.63 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD60 oral (rat) 0.012 mg/kg (*NIOSH/RTECS 1985) TPQ: 1/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 455-491°F, 235-255°C decomposes (Merck 1983, p. 514) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Contains water of hydration varying from 3 to 8 molecules of water; 1 g of hydrated salt dissolves in 7 mL (Merck 1983, P. 514) ------- CAS Registry Number: 316-42-7 Page 2 of 4 EMETINE, DIHYDROCHLORIDE SECTION II (continued) Appearance and Odor: Clusters of needles after drying at 221°F, 105°C; turns yellow on exposure to light or heat ((Merck 1983, p. 514) SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Not Found Skin: Not Found Ingestion: Yes (Sax 1984, p. 1275) Health Hazards (Acute, Delayed, and Chronic): This material is highly toxic orally. It is an eye irritant (Sax 1984, p. 1275). (Non-Specific — Emetine) Emetine is classified as extremely toxic. Probable oral lethal dose for humans is 5-50 mg/kg, or between 7 drops and one teaspoon for a 150-lb person (Gosselin 1984, p. II-244). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Emetine is an alkaloid (Merck 1983, p. 513). Extinguishing methods for alkaloid salts are as follows. Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: Procedures for alkaloid salts include the following. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits very toxic fumes of chlorides, hydrogen chloride and oxides of nitrogen (Sax 1984, p. 1275). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 316-42-7 Page 3 of 4 EMETINE, DIHYDROCHLORIDE SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Turns yellow on exposure to light or heat (Merck 1983, p. 514) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits very toxic fumes of chlorides, hydrogen chloride, and oxides of nitrogen (Sax 1984, p. 1275). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Emetine, dihydrochloride is an injectable form of emetine (Oilman 1984, p. 1051). It is an antiamebic (Merck 1983, p. 514). Emetine is the active ingredient of Ipecac (Gosselin 1984, p. 11-244). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) The following procedures should be used for alkaloid salts. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 316-42-7 Page 4 of 4 EMETINE, DIHYDROCHLORIDE SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: (Non-Specific — Emetine) Symptoms include nausea, vomiting, diarrhea, muscle weakness, pain, tenderness, hypotension, precordial pain and rapid heartbeat (Gosselin 1984, p. 11-244). Emergency and First Aid Procedures: Emetine is an alkaloid (Merck 1983, p. 513). Procedures for alkaloid salts are as follows. Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). COMMENTS: Sources searched but no information found: NFPA 1984 Weiss 1980 ACGIH 1983 NIOSH/OSHA 1978 Encyc Occupat Health and Safety 1983 Weast 1979 Physicians' Desk Reference 1985 Farm Chemicals Handbook 1984 ------- CAS Registry Number: 327-98-0 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- TRICHLORONATE CAS Registry Number: 327-98-0 Synonyms: 5082A; Agrisil; Agritox; Bay 37289; Bayer 37289; Bayer 5081; Bayer S 4400; Chemagro 37289; ENT 25,712; ENT-25712; Ethyl Trichlorophenylethylphosphonothioate; Fenophosphon; Fitosol; O-Ethyl O-2,4,5-Trichlorophenyl Ethylphosphonothioate; Phenol, 2,4,5-Trichloro-, O-Ester with O-Ethyl Ethylphosphonothioate; Phosphonothioic Acid, Ethyl-, O-Ethyl O-(2,4,5-Trichlorophenyl) Ester; Phytosol; Richloronate; S 4400; Trichloronat Chemical Formula: C10H12C18O2PS Molecular Weight: 333.60 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (cat) 10 mg/kg (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 226°F, 108°C at 0.01 mmHg (*Worthing 1979) Specific Gravity (H2O=1): 1.365 at 20°C/4°C (*Worthing 1979) Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 50.mg/liter at 20°C (*Worthing 1979) ------- AS Registry Number: 327-98-0 i'age 2 of 4 TRICHLOi ONATE SECTION II (continued) Appearance and Odor: Amber colored liquid (*Worthing 1979) SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Non-Specific -- Organic Phosphorus Pesticides) (Hayes 1982, p. 301) Skin: Yes (Non-Specific -- Organic Phosphorus Pesticides) (Hayes 1982, p. 301) Ingestion: Yes (Sax 1984, p. 1397) Health Hazards (Acute, Delayed, and Chronic): Material is an organophosphate (*Rumack 1975 to Present) and toxic effects are due to action on the nervous system (Hayes 1982, p. 301). It has high oral toxicity (Sax 1984, p. 1397) and death can occur in acute poisonings (*DeReuch 1979). Delayed neurotoxicity has been reported (*Rumack 1975 to Present). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Organophosphate Pesticide, Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific -- Organophosphate Pesticide, Liquid, n.o.s.) Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Wear positive pressure breathing apparatus and special protective clothing (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits very toxic fumes of chlorine containing compounds, phosphorus oxides, and sulfur oxides (Sax 1984, p. 1397). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 327-98-0 Page 3 of 4 TRICHLORONATE SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition it emits very toxic fumes of chlorine containing compounds, phosphorus oxides, and sulfur oxides (Sax 1984, p. 1397). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Non-systemic insecticide (*Worthing 1979). Not marketed in the U.S.A. or Canada (Farm Chemicals Handbook 1984, p. C-7). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation (see Section III above). (Non-Specific — Organophosphate Pesticide, Liquid, n.o.s.) Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. ------- CAS Registry Number: 327-98-0 Page 4 of 4 TRICHLORONATE SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Headache, dizziness, nausea, salivation, vomiting, abdominal pain, diarrhea, chest pain, decreased heart rate, excessive discharge of mucous from the air passages, difficult breathing, contraction of the pupil, blurred vision, profuse perspiration, muscle twitching and spasms, profound weakness, psychotic behavior, uncoordination, unconsciousness, rarely convulsions. Low level absorption syndrome is similar to influenza. High dosage may cause toxic psychosis similar to alcoholism. Exposures may be misdiagnosed as asthma and heart failure (*Rumack 1975 to Present). Emergency and First Aid Procedures: (Non-Specific -- Organophosphate Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 353-42-4 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- BORON TRIFLUORIDE COMPOUND WITH METHYL ETHER (1:1) CAS Registry Number: 353-42-4 Synonyms: (NIOSH/RTECS 1983 Synonym, Volume 1, p. 741) Boron, Trifluoro(Oxybis(methane))-,(T-4)-; Boron Trifluoride-Dimethyl Ether; (SANSS 1983 Synonyms): Methyl Ether, compound with Boron Fluoride (1:1); Boron Fluoride Complex with Dimethyl Ether; Boron Trifluoride Compound with Methyl Ether; Boron Trifluoride Dimethyl Ether Addition Compound; Boron Trifluoride Dimethyl Etherate; Boron Trifluoride Dimethyl Ether Complex Chemical Formula: C2H6O BFS Molecular Weight: 113.89 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LCjow inhalation (guinea pig) 0.233 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 1,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 126°C at 760 mmHg (Aldrich 1986, p. 190) Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Not Found ------- CAS Registry Number: 353-42-4 Page 2 of 4 BORON TRIFLUORIDE COMPOUND WITH METHYL ETHER (1:1) SECTION II (continued) Appearance and Odor: Not Found SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Sax 1984, p. 515) Skin: Yes (DOT 1984, Guide 29) Ingestion: Yes (Non-Specific — Boron Compounds) (Sax 1984, p. 513) Health Hazards (Acute, Delayed, and Chronic): This material is highly toxic by inhalation (Sax 1984, p. 515). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: This material may react violently with water. For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam (DOT 1984, Guide 29). Special Fire Fighting Procedures: Wear self-contained, positive- pressure breathing apparatus and full protective clothing. Move containers from fire area if possible. Do not get water inside containers. Spray cooling water on containers that are exposed to flame until well after fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire (DOT 1984, Guide 29). Unusual Fire and Explosion Hazards: Fire may produce irritating or poisonous gases. Flammable/combustible material which may be ignited by heat spark or flame. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion hazard indoors, outdoors, or in sewer. Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 29). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 353-42-4 Page 3 of 4 BORON TRIFLUORIDE COMPOUND WITH METHYL ETHER (1:1) SECTION V ~ REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits toxic fumes of fluorides (Sax 1984, p. 515). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI ~ USE INFORMATION Not Found SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away and isolate hazard area. Stay upwind and keep out of low areas. Shut off ignition sources. Do not touch spilled material. Use water spray to reduce vapors, but do not get water inside containers. For small spills, absorb with sand or other noncombustible absorbent material and place into containers. For large spills, dike far ahead of spill for later disposal (DOT 1984, Guide 29). SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Contact may cause burns to skin and eyes (DOT 1984, Guide 29). Emergency and First Aid Procedures: Move victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing at site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Keep victim quiet and maintain normal body temperature (DOT 1984, Guide 29). ------- CAS Registry Number: 353-42-4 Page 4 of 4 BORON TRIFLUORIDE COMPOUND WITH METHYL ETHER (1:1) COMMENTS: Sources searched but no information found: ACGIH 1983 NIOSH/OSHA 1978 Hawley 1981 Weast 1979 Merck 1983 NFPA 1984 Student 1981 Weiss 1980 CHRIS 1978 Doull 1980 Clayton and Clayton 1981-82 Arena 1979 Gosselin 1984 Encyc Occupat Health and Safety 1983 Buchel 1983 Farm Chemicals Handbook 1984 Hayes 1982 Physicians' Desk Reference 1985 Oilman 1985 ------- CAS Registry Number: 359-06-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - FLUOROACETYL CHLORIDE CAS Registry Number: 359-06-8 Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 252): Acetyl Chloride, Fluoro-; TL 670 Chemical Formula: C2H2C1FO Molecular Weight: 96.49 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LClow inhalation (guinea pig) 0.1 mg/liter/10 minutes (*NIOSH/RTECS 1985) TPQ: 10 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Not Found Appearance and Odor: Not Found ------- CAS Registry Number: 359-06-8 Page 2 of 4 FLUOROACETYL CHLORIDE SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Sax 1984, p. 1430) Skin: Not Found Ingestion: Yes (Non-Specific -- Chloroacetyl Chloride) (NFPA 1984, p. 49-29) Health* Hazards (Acute, Delayed, and Chronic): Highly toxic by inhalation (Sax 1984, p. 1430). (Non-Specific - Chloroacetyl Chloride) Corrosive to skin and irritating to eyes (NFPA 1984, p. 49-29). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific -- Chloroacetyl Chloride and Fluoroacetic Acid) Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 59). Special Fire Fighting Procedures: (Non-Specific - Chloroacetyl Chloride and Fluoroacetic Acid) Spray cooling water on containers that are exposed to flames until well after fire is out. Move container from fire area if you can do so without risk. Do not get water in container, as material may react violently with water (DOT 1984, Guide 59). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits very toxic fumes of chlorine and fluorine-containing compounds (Sax 1984, p. 1430). (Non-Specific -- Chloroacetyl Chloride and Fluoroacetic Acid) Some of these materials may ignite combustibles (i.e., wood, paper, oil, etc.) or react violently with water (DOT 1984, Guide 59). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found ------- CAS Registry Number: 359-06-8 Page 3 of 4 FLUOROACETYL CHLORIDE SECTION V (continued) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits very toxic fumes of chlorine and fluorine-containing compounds (Sax 1984, p. 1430). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Not Found SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Chloroacetyl Chloride and Fluoroacetic Acid) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors (may react violently with water). Small spills: absorb with sand or other non-combustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 59). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Not Found Emergency and First Aid Procedures: (Non-Specific ~ Chloroacetyl Chloride and Fluoroacetic Acid) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Remove and isolate contaminated clothing and shoes at site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 59). ------- CAS Registry Number: 359-06-8 Page 4 of 4 FLUOROACETYL CHLORIDE COMMENTS Sources searched but no information found: Weast 1979 Hawley 1981 Hayes 1982 DASE 1980 ACGIH 1983 NIOSH/OSHA 1978 Merck 1983 Oilman 1985 Gosselin 1984 Weiss 1980 Clayton and Clayton 1981-82 Farm Chemicals Handbook 1984 Doull 1980 Buchel 1983 ------- CAS Registry Number: 371-62-0 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ETHYLENE FLUOROHYDRIN CAS Registry Number: 371-62-0 Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 252): Ethanol, 2-Fluoro-; beta-Fluoroethanol; 2-Fluoroethanol; TL 741 Chemical Formula: C2H5FO Molecular Weight: 64.07 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (dog) 0.007 mg/liter/10 minutes (*NIOSH/RTECS 1985) TPQ: 10 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 218.3°F, 103.5°C (Weast 1979, p. C-297) Specific Gravity (H2O=1): 1.1040 at 20°C/4°C (Weast 1979, p. C-297) Vapor Pressure (mmHg): Not Found Melting Point: -15.61°F, -26.45°C (Weast 1979, p. C-297) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Miscible (Weast 1979, p. C-297) Appearance and Odor: Liquid (Hayes 1983, p. 500) ------- AS Registry Number: 371-62-0 . age 2 of 4 ETHYLL. _ FLUOROHYDRIN SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Sax 1984, p. 1437) Skin: Yes (Sax 1984, p. 1437) Ingestion: Yes (Hayes 1982, p. 500) Health Hazards (Acute, Delayed, and Chronic): Toxicity rating is the same as for fluoroacetate, super toxic. The probable oral lethal dose in humans is a taste (less than 7 drops) for a 70 kg (150 Ib.) person (Gosselin 1984, p. 11-198). The chemical is highly toxic when inhaled or absorbed through the skin (Sax 1984, p. 1437). Toxicity depends on its oxidation to fluoroacetate by tissue alcohol dehydrogenase (Hayes 1982, p. 500). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 31°C (Hayes 1982, p. 500) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Toxic fluoride fumes may be emitted in a fire (Sax 1984, p. 1437). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits very toxic fumes of fluorides (Sax 1984, p. 1437). ------- CAS Registry Number: 371-62-0 Page 3 of 4 ETHYLENE FLUOROHYDRIN SECTION V (continued) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Ethylene Fluorohydrin is used as a rodenticide (Hayes 1982, p. 500), insectide (Gosselin 1984, p. III-193), and acaricide (Buchel 1983, p. 177). Not registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985). SECTION VII « PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation and skin contact (see Section III above). (Non-Specific -- Fluoroacetic Acid) Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 59). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl GOOD/LIMITED** CPE GOOD/LIMITED** Viton GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms include tremors, severe muscular weakness, nausea, headache, and slight swelling of the liver (Hayes 1982, p. 500). Delayed convulsant (Gosselin 1984, p. II-198). ------- CAS Registry Number: 371-62-0 Page 4 of 4 ETHYLENE FLUOROHYDRIN SECTION IX (continued) Emergency and First Aid Procedures: Acute poisoning should be treated like poisoning by fluoroacetate. Ethylene fluorbhydrin (2-fluoroethanol) is listed among the organic fluorine derivatives of fluoroacetic acid (Hayes 1982, p. 501). The emergency procedures for f luoroacetic acid are: move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 59). COMMENTS Sources searched but no information found: Student 1981 DASE 1980 Hawley 1981 NFPA 1984 Weiss 1980 Merck 1983 CHRIS 1978 Farm Chemicals Handbook 1984 ------- CAS Registry Number: 379-79-3 Page 1 of 3 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- ERGOTAMINE TARTRATE CAS Registry Number: 379-79-3 Synonyms: (SANSS 1983 Synonyms) Ergotamine Bitartrate; Gotamine Tartrate; Gynergen; Neo-ergotin; Ergotaman-3',6',18-Trione, 12'-Hydroxy-2'-Methyl-5'-(Phenylmethyl)-, (S'.alpha.)-, [R-(R*,R*)]- 2,3-Dihydroxybutanedioate (2:1) (Salt); Ergam; Ergate; Ergomar; Etin; Exmigra; Rigetamin; Secagyn; Secupan; Ergotamine, Tartrate (2:l)(Salt); Component of Cafergot Chemical Formula: C66H70N10O10-C4H6O6 Molecular Weight: 1313.56 SECTION I --REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDlow oral (rat,rabbit) 1 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 397°F, 203°C, decomposes (Merck 1983, p. 529) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 1 g/500 mL (Merck 1983, p. 529) ------- CAS Registry Number: 379-79-3 Page 2 of 3 ERGOTAMINE TARTRATE SECTION II (continued) Appearance and Odor: Powder or liquid forms available as drugs (Gilman 1985, p. 938). SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Gilman 1985, p. 938) Skin: Not Found Ingestion: Yes (NIOSH/RTECS 1983, p. 209) Health Hazards (Acute, Delayed, and Chronic): High oral toxicity and a convulsant in humans (Sax 1984, p. 1295). Medical Conditions Generally Aggravated by Exposure: People with liver damage are at a greater risk (Gilman 1985, p. 937). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Not Found Special Fire Fighting Procedures: Not Found Unusual Fire and Explosion Hazards: Not Found NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Protect from light and heat (Merck 1983, p. 529) Hazardous Decomposition or Byproducts: When * :' to decomposition, it emits toxic fumes of nitrogen oxides (Sax 198-,. .). ------- CAS Registry Number: 379-79-3 Page 3 of 3 ERGOTAMINE TARTRATE SECTION V (continued) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION The major uses of the ergot alkaloids fall into two categories: applications in obstetrics and treatment of migraine headaches (Oilman 1985, p. 937). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Alkaloid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Do not touch spilled material; stop leak if you can do so without risk. Use water vapor to reduce vapors. Absorb spills with sand or other noncombustible absorbent material. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. For large spills, dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Nausea and vomiting occur in some patients after oral administration. Weakness in the legs is common and muscle pains in the extremities may occur. Numbness and tingling of the fingers and toes may also occur (Oilman 1985, p. 938). Emergency and First Aid Procedures: (Non-Specific -- Alkaloid, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 465-73-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - ISODRIN CAS Registry Number: 465-73-6 Synonyms: l,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-Hexachloro- l,4,4a,5,8,8a-Hexahydro-, endo,endo-; Compound 711; ENT 19,244; Experimental Insecticide 711; l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-Hexahydro-l,4; 5,8- endo,endo-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a- Hexahydro-endo,endo-l,4:5,8-Dimethanonaphthalene; l,4:5,8-Dimethanonaphthalene, l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-Hexahydro-, (1 alpha, 4 alpha, 4a beta, 5 beta, 8 beta, 8a beta)-; SD 3418 Chemical Formula: C12H8C16 Molecular Weight: 364.90 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 7 mg/kg (*NIOSH/RTECS 1985) TPQ: 100/10,000 (pounds) RQ: 1 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 464-468°F, 240-242°C (Sax 1984, p. 1641) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Not Found ------- CAS Registry Number: 465-73-6 Page 2 of 4 ISODRIN SECTION II (continued) Appearance and Odor: Solid (*Hawley 1977) SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Non-Specific -- Aldrin) (Sax 1984, p. 153) Skin: Yes (Sax 1984, p. 1641) Ingestion: Yes (Sax 1984, p. 1641) Health Hazards (Acute, Delayed, and Chronic): It is classified as extremely toxic. Probable oral lethal dose for humans is 5-50 mg/kg or between 7 drops and 1 teaspoonful for a 70 kg (150 Ib.) person. It causes renal damage and hyperactivity of sympathetic nervous system (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Material is related to aldrin (*Gosselin 1976). (Non-Specific — Aldrin) Extinguish by using water spray, dry chemical, foam, or carbon dioxide. Use water to keep fire exposed containers cool (NFPA 1984, p. 49-13). Special Fire Fighting Procedures: (Non-Specific - Aldrin) Wear full protective clothing (NFPA 1984, p. 49-13) including positive pressure breathing apparatus. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: (Non-Specific — Aldrin) This material may burn but may not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 465-73-6 Page 3 of 4 ISODRIN SECTION V - REACTIVITY DATA Stability: Unstable: Yes (*White-Stevens 1971) Stable: Conditions to Avoid: Reactions induced by light or acid (*White-Stevens 1971) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: Material is related to aldrin (*Gosselin 1976). (Non-Specific — Aldrin) When heated to decomposition it emits toxic fumes of chlorine (Sax 1984, p. 153). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION No longer used as a pesticide (*NIOSH/RTECS 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Material is related to aldrin (*Gosselin 1976). (Non-Specific -- Aldrin) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry containers and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms experienced are similar to poisoning by dieldrin and aldrin, including overall discomfort, headache, nausea, vomiting, dizziness, tremors, convulsions, rise in blood pressure, fever, disturbances in sleep and behavior, and rapid heartbeat. Death from respiratory arrest may occur in coma (*Gosselin 1976, *Merck 1976). ------- CAS Registry Number: 465-73-6 Page 4 of 4 ISODRIN SECTION IX (continued) Emergency and First Aid Procedures: Procedures are similar to those for dieldrin and aldrin poisoning (*Gosselin 1976). Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 470-90-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - CHLORFENVINFOS CAS Registry Number: 470-90-6 Synonyms: Supona; 2,4-Dichloro-alpha-(Chloromethylene)Benzyl Diethyl Phosphate; 2-Chloro-l-(2,4-Dichlorophenyl)Ethenyl Diethyl Ester Phosphoric Acid; 2-Chloro-l-(2,4-Dichlorophenyl)Vinyl Diethyl Phosphate; 4072; Benzyl Alcohol, 2,4-Dichloro-alpha-(Chloromethylene)-, Diethyl Phosphate; beta-2-Chloro-l-(2',4'-Dichlorophenyl)Vinyl Diethyl Phosphate; Birlan; Birlane; C8949; Chlofenvinphos; Chlorofenvinphos; Chlorphenvinfos; Chlorphenvinphos; Compund 4072; CVP; CVP (Pesticide); Dermaton; Diethyl l-(2,4-Dichlorophenyl)-2-Chlorovinyl Phosphate; Diethyl 2-Chloro-l- (2,4-Dichlorophenyl)Vinyl Phosphate; ENT 24969; GC 4072; GS 4072; QMS 1328; Phosphoric Acid, 2-Chloro-l-(2,4-Dichlorophenyl)Ethenyl Diethyl Ester; Phosphoric Acid, 2-Chloro-l-(2,4-Dichlorophenyl)Vinyl Diethyl Ester; Sapecron; SD 4072; Shell 4072; Supone; Vinyphate Chemical Formula: C12H14C13O4P Molecular Weight: 359.56 SECTION I ~ REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 10 mg/kg (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 333-338°F, 167-170°C at 0.5 mmHg (*Worthing 1979) Specific Gravity (H2O=1): 1.36 at 15.5°C/16.5°C (*Worthing 1979) Vapor Pressure (mmHg): 0.000004 at 20°C (*Worthing 1979) Melting Point: -2 to -9°F; -19 to -23°C (*Worthing 1979) ------- CAS Registry Number: 470-90-6 Page 2 of 4 CHLOkf LNVINFOS SECTION I (continued) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 145 mg/liter at 23°C (*Worthing 1979). Appearance and Odor: Amber-colored liquid with mild chemical odor (*Worthing 1979; *Spencer 1973). SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) (DOT 1984, Guide 55) Skin: Yes (Hayes 1982, p. 396) Ingestion: Yes (Hayes 1982, pp. 396-97) Health Hazards (Acute, Delayed, and Chronic): Acute: cholinesterase inhibitor which affects central nervous system. Severe illness or death possible (Hayes 1982, pp. 396-397). Convulsions or coma and death (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Wear positive pressure breathing apparatus and special protective clothirr- ^DOT 1984, Guide 55). ------- CAS Registry Number: 470-90-6 Page 3 of 4 CHLORFENVINFOS SECTION IV (continued) Unusual Fire and Explosion Hazards: (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) This material may burn but does not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes, when stored in glass or polyethylene lined containers (*Worthing 1979) Conditions to Avoid: Alkaline aqueous solutions (*Merck 1976) Incompatibility (Materials to Avoid): Iron, steel, and brass (*Worthing 1979). Hazardous Decomposition or Byproducts: Not Found Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Used for control of ticks, flies, lice, and mites on cattle and for blowfly, lice, ked, and itchmite on sheep (*Farm Chemicals Handbook 1980). Controls fleas and mites on dog; do not use on cats. Used on organic wastes and breeding places of fly larvae, including diary barns (*Rossoff 1974; Hayes 1982, p. 396). Also used as a foliage insecticide for potatoes, rice, maize, and sugar cane. Used to control soil insects, i.e., rootflies, rootworms, and cutworms (*Spencer 1973). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) In case of spill or leak, do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other non-combustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal. Keep unnecesary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site (DOT 1984, Guide 55). ------- CAS Registry Number: 470-90-6 Page 4 of 4 CHLORFENVINFOS SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Butyl/Neoprene GOOD/LIMITED** Viton/Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Symptoms typical of cholinesterase poisoning. Nausea is often first symptom, with vomiting, abdominal cramps, diarrhea, and excessive salivation. Headache, giddiness, weakness, tightness in chest, blurring of vision, pinpoint pupils, loss of muscle coordination, and difficulty breathing. Convulsions and coma precede death (*Gosselin 1976). Emergency and First Aid Procedures: (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 502-39-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - METHYLMERCURIC DICYANAMIDE CAS Registry Number: 502-39-6 Synonyms: (Cyanoguanidino)Methylmercury; Agrosol; Cyano(Methylmercuri) Guanidine; Guanidine, Cyano(Methylmercurio)-; Guanidine, Cyano-, Methylmercury Deriv; Mercury, (3-Cyanoguanidino)Methyl-; Mercury, (Cyanoguanidinato)Methyl-; Mercury, (Cyanoguanidinato-N')Methyl-; Methyl Mercuric Dicyandiamide; Methylmercuric Cyanoguanidine; MMD; Morsodren; Morton EP-227; Morton Soil Drench; Morton Soil-Drench-C; N-Cyano-N'-(Methyl-mercury)Guanidine; Pano-Drench; Pano-Drench 4; Panodrin A-13; Panogen; Panogen 15; Panogen 43; Panogen 8; Panogen PX; Panogen Turf Spray; Panogen (Old); Panospray 30; R 8; R 8 (Fungicide); MEMA; Methylmercuric Dicyandiamide; Methylmercury dicyandiamide; Panogen Turf Fungicide Chemical Formula: CsH6HgN4 Molecular Weight: 298.72 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (mouse) 20 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): In Mercury Compounds category SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): 0.000065 at 35°C (*Martin and Worthing 1974) Melting Point: 313°F, 156°C (*Hawley 1981) Vapor Density (AIR=1): Not Found ------- CAS Registry Number: 502-39-6 Page 2 of 4 METHYLMERCURIC DICYANAMIDE SECTION II (continued) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 2.17 g/100 ml at room temperature (*Martin and Worthing 1974); soluble (Hawley 1981, p. 295) Appearance and Odor: Crystals (*Hawley 1981) SECTION III - HEALTH HAZARD DATA OSHA PEL: TWA 0.01 mg/m3; ceiling concentration 0.04 mg/m3 (NIOSH/RTECS 1983, Volume 2, p. 662) ACGIH TLV: TWA 0.01 mg (Hg)/m3; STEL (ceiling) 0.03 mg (Hg)/m3 (skin) (NIOSH/RTECS 1983, Volume 2, p. 662) IDLH: Not Found < Other Limits Recommended: IDLH for organo (alkyl) mercury compounds is 10 mg/m3 (NIOSH/OSHA 1978, p. 144). Routes of Entry: Inhalation: Yes (Gosselin 1984, p. 11-137) Skin: Yes (Gosselin 1984, p. II-137) Ingestion: Yes (Sax 1984, p. 1868) Health Hazards (Acute, Delayed, and Chronic): Methylmercuric dicyanamide is extremely toxic to humans. The probable lethal dose for humans is 5-50 mg/kg of body weight (between 7 drops and one teaspoon for a 150 Ib. person) (*Gosselin 1984). Humans may be poisoned by feeding on the flesh of animals which have ingested this fungicide (*Clark 1981). Eating treated seeds may also cause poisoning. The poisoning may show delayed manifestations on the nervous system. Patients frequently become gradually worse after their illness is recognized and exposure is stopped (Hayes, 1982, p. 21). This compound is a strong skin irritant and produces blisters and other dermatitis (*Gosselin 1976). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific -- Mercury-Based Pesticide, n.o.s.) This material may burn but will not ignite readily. For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam (DOT 1984, Guide 55). ------- CAS Registry Number: 502-39-6 Page 3 of 4 METHYLMERCURIC DICYANAMIDE SECTION IV (continued) Special Fire Fighting Procedures: (Non-Specific -- Mercury-Based Pesticide, n.o.s.) Fight fire from maximum distance. Dike fire control water for later disposal. Wear positive pressure breathing apparatus and special protective clothing (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: (Non-Specific — Mercury-Based Pesticide, n.o.s.) This material may burn but does not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found SECTION V - REACTIVITY DATA Stability: Unstable: Stable: Yes (*Martin and Worthing 1974) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, it emits very toxic fumes of mercury and nitrogen oxides (Sax 1984, p. 1868). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Fungicide; a seed, soil, and turf treatment (Buchel 1983, p. 249) especially for cereals, sorghum, sugar beets, cotton, and flax (Hayes 1982, p. 20). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Mercury-Based Pesticide n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering. Remove and isolate contaminated clothing at the site. Do not touch spilled material. Use water to reduce vapors. In event of spill or leak: take up with absorbent material and place in containers with covers. Small dry spill: with clean shovel place material into clean, dry container and cover; move containers from spill area. Dike far ahead of spill if large (DOT 1984, Guide 55). ------- CAS Registry Number: 502-39-6 Page 4 of 4 METHYLMERCURIC DICYANAMIDE SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Prolonged exposure to skin may produce . blisters (*Gosselin 1984). In the case of ingestion there is nausea and abdominal pain. Vomiting and diarrhea may occur. Burning or prickling of the lips, tongue, and extremities. The patient may be confused, hallucinate, be irritable, have disturbed sleep, lose muscular coordination and lose memory. Visual fields may narrow concentrically; emotional instability may occur as well as inability to concentrate, with stupor and coma (*Rumack 1975 to Present). Emergency and First Aid Procedures: (Non-Specific -- Mercury-Based Pesticide, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 504-24-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- PYRIDINE, 4-AMINO- CAS Registry Number: 504-24-5 Synonyms: 4-Aminopyridine; 4-AP; 4-Pyridinamine; 4-Pyridylamine; Amino-4 Pyridine; Avitrol; gamma-Aminopyridine; MI-W-3; p-Aminopyridine; Phillips 1861; VMI 10-3 Chemical Formula: CEH6N2 Molecular Weight: 94.13 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 20 mg/kg (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1000 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: 524.3°F, 273.5°C (*Hawley 1977) Specific Gravity (H2O=1): Not Found Vapor Pressure (mmHg): Not Found Melting Point: 318.0°F, 158.9°C (*Hawley 1977) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Moderately soluble (*Farm Chemicals Handbook 1981) Appearance and Odor: White crystalline material with no odor (*Farm Chemicals Handbook 1981). ------- CAS Registry Number: 504-24-5 Page 2 of 4 PYRIDINE, 4-AMINO- SECTION III -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*DOT 1984) Skin: Yes (*DOT 1984) Ingestion: Yes (Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes (*DOT 1984). Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias (*Rumack 1975 to Present). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: The material may burn but will not ignite easily. To extinguish use dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 55). Special Fire Fighting Procedures: Wear positive pressure self-contained breathing apparatus and special protective clothing. Move container from fire area if you can do so without risk. Fight fire from maximum distance possible. Control runoff water with dikes and prevent material from scattering (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off poisonous gases (DOT 1984, Guide 55). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Stable: Yes (*Farm Chemicals Handbook 1981) Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Not Found ------- CAS Registry Number: 504-24-5 Page 3 of 4 PYRIDINE, 4-AMINO- SECTION V (continued) Hazardous Decomposition or Byproducts: It may emit irritating or poisonous gases in fire conditions (DOT 1984, Guide 55). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found SECTION VI -- USE INFORMATION Material is used as an avicide (bird repellant), an intermediate and as a fixer in some textile dyes (*Rumack 1975 to Present, *Hawley 1977). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Keep unnecessary people away; isolate the hazardous area and deny entry. Stay upwind. Do not touch spilled material; stop leak if possible without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (*DOT 1984). SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Nitrile POOR/LIMITED** PVC POOR/LIMITED** Viton GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Rapid onset of disagreeable taste, immediate burning of throat, and abdominal discomfort; in addition, weakness, dizziness, disorientation, and seizures may occur. Delayed symptoms of oral ingestion include elevated liver enzymes, and respiratory arrest (*Rumack 1975 to Present). ------- CAS Registry Number: 504-24-5 Page 4 of 4 PYRIDINE, 4-AMINO- SECTION IX (continued) Emergency and First Aid Procedures: Move victim to fresh air; call emergency medical care. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least fifteen minutes (*DOT 1984). ------- CAS Registry Number: 505-60-2 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - MUSTARD GAS CAS Registry Number: 505-60-2 Synonyms: Sulfide, bis(2-Chloroethyl); l,l'-Thiobis(2-Chloroethane); 1 -Chloro-2-(beta-Chloroethylthio)Ethane; 2,2'-Dichlorodiethyl Sulfide; 2,2'-Dichlorodiethyl Sulphide; 2,2'-Dichloroethyl Sulfide; 2,2'-Dichloroethyl Sulphide; beta, beta'-Dichloroethyl Sulfide; beta, beta'-Dichloroethyl Sulphide; beta,beta-Dichlor-Ethyl-Sulphide; Bis(2-Chloroethyl) Sulfide; Bis(2-Chloroethyl) Sulphide; Bis(beta-Chloroethyl) Sulfide; Bis(beta-Chloroethyl) Sulphide; Di-2-Chloroethyl Sulfide; Di-2-Chloroethyl Sulphide; Distilled Mustard; Ethane, l,l'-Thiobis(2-Chloro-; H; HD; Kampfstoff "Lost"; Mustard HD; Mustard Vapor; Mustard, Sulfur; S Mustard; S-Lost; S-Yperite; Schwefel-Lost; Sulfur Mustard; Sulfur Mustard Gas; Sulphur Mustard; Sulphur Mustard Gas; Yellow Cross Liquid; Yperite Chemical Formula: C4H8C12S Molecular Weight: 159.08 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC50 inhalation (rat) 0.42 mg/liter/2 minutes (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): Yes SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 419-423°F, 215-217°C (*Merck 1976) Specific Gravity (H2O=1): 1.274 at 20°C/4°C (liquid) (*Merck 1976) Vapor Pressure (mmHg): 0.090 at 30°C (*Merck 1976) Melting Point: 55-57°F, 13-14°C (*Merck 1976) Vapor Density (AIR=l):-~5.4 (*Sax 1975) ------- CAS Registry Number: 505-60-2 Page 2 of 4 MUSTARD GAS SECTION II (continued) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: 0.68 g/liter at 25°C (*IARC 1972-1985); very sparingly soluble in water (Merck 1983, p. 904). Appearance and Odor: Colorless oily liquid (*IARC 1972-1985) with a weak, sweet odor (*Merck 1976) or garlic-like odor (U.S. Army 1975, p. 3-8). SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: Not Found IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Sax 1975) Skin: Yes (*Sax 1975) Ingestion: Yes (*Sax 1975) Health Hazards (Acute, Delayed, and Chronic): The median lethal dosage is 1500 mg-minute/m3 for inhalation and 10,000 mg-minute/ms for skin absorption (masked personnel). The median incapacitating dosage is 200 mg-minute/m3 for eye injury and 2000 mg-minute/ms for skin absorption (masked personnel). Wet skin absorbs more material than dry skin (U.S. Army 1975, p. 3-8). May cause death or permanent injury after very short exposure to small quantities (*Sax 1975). It is a blistering gas and is highly irritating to eyes, skin, and lungs. Pulmonary lesions are often fatal (Sax 1984, pp. 461-462). Permanent eye damage and severe respiratory impairment. It is a carcinogen (Merck 1983, p. 904). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV -- FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): 221°F, 105°C (*Sax 1975) Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: Extinguish with water, foam, dry chemical, or carbon dioxide (*Sax 1975). Special Fire Fighting Procedures: Protective clothing and self-contained breathing apparatus required in presence of mustard g?' '*Sax 1975). Cool all affected containers with flooding quantities of ^ .-..pply water from as far a distance as possible (Student 1981, p ------- CAS Registry Number: 505-60-2 Page 3 of 4 MUSTARD GAS SECTION IV (continued) Unusual Fire and Explosion Hazards: Can be ignited by large explosive charge. When heated to decomposition, emits highly toxic fumes of oxides of sulfur and chlorine containing compounds. Reacts with water or steam to produce toxic and corrosive fumes (*Sax 1975). Containers may rupture violently in a fire (Student 1981, p. 358). NFPA Flammability Rating: Not Found SECTION V -- REACTIVITY DATA Stability: Unstable: Yes; hydrolyzed in aqueous solution (*IARC 1972-1985) Stable: Conditions to Avoid: High heat; contact with acid or acid fumes (*Sax 1984, p. 482). Incompatibility (Materials to Avoid): Incompatible with bleaching powder (Sax 1984, p. 482). Reacts violently with oxidizing materials. Reacts with water or steam to produce toxic and corrosive fumes (*Sax 1975). Hazardous Decomposition or Byproducts: Emits highly toxic fumes of oxides of sulfur and chlorine containing compounds when heated to decomposition or on contact with acid or acid fumes (*Sax 1974) Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION It has been used as a chemical warfare agent (*IARC 1972-1985) and as a chemical intermediate. It is not produced commercially in the U.S. (*SRI). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) To clean up a spill, cover with up to 15 percent calcium hypochloride. Place in container; neutralize after 12 hours if necessary (*Rumack 1975 to Present). Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Attempt to stop leak if without hazard. Use water spray to knock down vapors. Avoid breathing vapors and bodily contact with the material. Keep upwind. Wash away any material which may have contacted the body with copious amounts of soap and water. Downwind evacuation must be considered (Student 1981, p. 358). ------- CAS Registry Number: 505-60-2 Page 4 of 4 MUSTARD GAS SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: May cause conjunctivitis and blindness. In 1-12 hours there may be coughing, swollen eyelids, reddened skin, and severe itching. There may be swelling and destruction of tissue in the respiratory tract and exposed skin. Ingestion may cause nausea and vomiting (*Merck 1976). Emergency and First Aid Procedures: Remove patient from contaminated atmosphere as rapidly as possible. Irrigate exposed eyes with water for at least 15 minutes. Wash exposed areas of the skin twice with soap and water. Local lesions should be cleaned and treated similarly to burns with emollients (*Rumack 1975 to Present). ------- CAS Registry Number: 506-61-6 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- POTASSIUM SILVER CYANIDE CAS Registry Number: 506-61-6 Synonyms: Argentate(l-), bis(Cyano-C)-, Potassium; Argentate(l-), Dicyano-, Potassium; Argentates(I) (Sol), Dicyano-; Potassium Argentocyanide; Potassium bis(Cyano-C)Argentate(l-); Potassium Dicyanoargentate; Potassium Dicyanoargentate (KAg(CN)2); Potassium Dicyanoargentate(l-); Potassium Dicyanoargentate(I); Potassium Silver Cyanide (KAg(CN)2); Silver Potassium Cyanide [AgK(CN)2] Chemical Formula: C2AgN2'K Molecular Weight: 199.01 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LD50 oral (rat) 21 mg/kg (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 1 (pounds) Section 313 Listed (Yes or No): In Cyanide Compounds and Silver Compounds categories SECTION II ~ PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 2.36 at 25°C (*Hawley 1977) Vapor Pressure (mmHg): Not Found Melting Point: Not Found Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (*Merck 1976) ------- CAS Registry Number: 506-61-6 Page 2 of 4 POTASSIUM SILVER CYANIDE SECTION II (continued) Appearance and Odor: White crystals (*Merck 1976) SECTION HI -- HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: (Cyanides) TWA 5 mg/ms, as cyanide (skin) (AGCIH 1986-87, p.14) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present) Skin: Yes (*Rumack 1975 to Present) Ingestion: Yes (*Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): The primary health hazard is as a cyanide (*Gosselin 1976). (Non-specific -- Cyanide, Inorganic, n.o.s.). It is poisonous and may be fatal if inhaled, swallowed or absorbed through the skin. Fire may produce irritating or poisonous gases (DOT 1984, Guide 55). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV « FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific — Cyanide, Inorganic, n.o.s.) Use dry chemical, carbon dioxide, water spray, or foam for small fire, and water spray, fog, or foam for large fires. Move containers of this material away from fire area if this can be done without risk (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific — Cyanide, Inorganic, n.o.s.) Isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Fight fire from maximum distance. Dike fire control water for later disposal. Do not scatter the material (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition, potassium silver cyanide emits very toxic fumes of cyanide and nitrogen oxides (Sax 1984, p. 2282). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 506-61-6 Page 3 of 4 POTASSIUM SILVER CYANIDE SECTION V - REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Light (*Merck 1976) Incompatibility (Materials to Avoid): Not Found Hazardous Decomposition or Byproducts: When heated to decomposition, potassium silver cyanide emits very toxic fumes of cyanide and nitrogen oxides (Sax 1984, p. 2282). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Potassium silver cyanide is used in silver plating, as a bactericide (*Merck 1976), and in the manufacture of antiseptics (*Hawley 1977). Not registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Avoid inhalation or skin contact (see Section III above). (Non-Specific -- Cyanide, Inorganic, n.o.s.) Do not touch spilled materials; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) Neoprene GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 506-61-6 Page 4 of 4 POTASSIUM SILVER CYANIDE SECTION IX - EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: As a cyanide, massive doses may produce, without warning, sudden loss of consciousness and prompt death from respiratory arrest. Smaller but still lethal doses result in illness that may be prolonged for 1 or more hours. Other symptoms may include numbness in throat, salivation, nausea, anxiety, dizziness, irregular breathing, odor of bitter almonds may be noted on breath, blood pressure may rise, slowing of the heart beat, sensation of constriction in the chest, unconsciousness followed by violent convulsions and paralysis (*Gosselin 1976). Emergency and First Aid Procedures: (Non-Specific -- Cyanide, Inorganic, n.o.s.) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). ------- CAS Registry Number: 506-68-3 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - CYANOGEN BROMIDE CAS Registry Number: 506-68-3 Synonyms: Bromine Cyanide; Bromocyan; Bromocyanide; Bromocyanogen; Campilit; Cyanobromide; Cyanogen Monobromide; TL 822 Chemical Formula: CBrN Molecular Weight: 105.93 SECTION I ~ REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LClow inhalation (human) 0.398 mg/liter/10 minutes (*NIOSH/RTECS 1985) TPQ: 500/10,000 (pounds) RQ: 1000 (pounds) Section 313 Listed (Yes or No): No SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: 142°F, 61.4°C (*Weast 1979) Specific Gravity (H2O=1): 2.015 at 20°C/4°C (*Merck 1976) Vapor Pressure (mmHg): 92 at 20°C (*Patty 1963) Melting Point: 126°F, 52°C (*Merck 1976) Vapor Density (AIR=1): 3.62 (*Patty 1963) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Soluble (*Weast 1979) Appearance and Odor: Colorless to white cubes or needle-like crystals with a penetrating odor (*Merck 1976; *Sax 1979; *NFPA 1978; *Patty 1963) ------- CAS Registry Number: 506-68-3 Page 2 of 4 CYANOGEN BROMIDE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: (Cyanides) TWA 5mg/m3, as cyanide (skin) (ACGIH 1986-87, p. 14) IDLH: Not Found Other Limits Recommended: Suggested TLV less than 0.5 ppm (*Patty 1963). Routes of Entry: Inhalation: Yes (*NIOSH 1979) Skin: Yes (*Rumack 1975 to Present) Ingestion: Yes (*Rumack 1975 to Present) Health Hazards (Acute, Delayed, and Chronic): Super toxic; probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). Vapors are highly irritant and very poisonous (*Merck 1976). Medical Conditions Generally Aggravated by Exposure: Individuals with chronic diseases of the kidneys, respiratory tract, skin, or thyroid are at greater risk of developing toxic cyanide effects (*Encyc Occupat Health and Safety 1983). SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: Noncombustible (NFPA 1978, p. 49-34) LEL: Not Found UEL: Not Found Extinguishing Methods: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. Use foam, carbon dioxide, or dry chemical. Cool all affected containers with flooding quantities of water. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to absorb vapors. Keep material out of water sources and sewers. Use water spray to knock down vapors (Student 1981, p. 158). Special Fire Fighting Procedures: Wear full protective clothing. Avoid direct water contact as it will cause cyanogen bromide to decompose, releasing toxic gases (*NFPA 1978). Avoid breathing vapors or dusts; keep upwind; wear self-contained breathing apparatus (Student 1981, p. 158). Unusual Fire and Explosion Hazards: Cyanogen bromide is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode (*Merck 1976). A violent reaction may take place on contact with large quantities of acid (*NFPA 1978). Vapors are highly irritating (*Merck 1976). NFPA Flammability Rating: 0 ------- CAS Registry Number: 506-68-3 Page 3 of 4 CYANOGEN BROMIDE SECTION V - REACTIVITY DATA Stability: Unstable: Yes, impure material decomposes rapidly and tends to explode (*Merck 1976) Stable: Conditions to Avoid: Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control (*NFPA 1978). Incompatibility (Materials to Avoid): Water, acids (*NFPA 1978) Hazardous Decomposition or Byproducts: When material is heated to decomposition, it emits very toxic fumes of cyanide and bromide (Sax 1984, p. 825). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI -- USE INFORMATION Cyanogen bromide is used in organic synthesis, as a fumigant, a pesticide, in cellulose technology, and in gold-extraction (*Patty 1963). Not registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985). SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987) (Chemical Resistance/Amount of Data) CPE GOOD/LIMITED** *Based on qualitative performance information. **Based on a chemical analog. ------- CAS Registry Number: 506-68-3 Page 4 of 4 CYANOGEN BROMIDE SECTION IX -- EMERGENCY TREATMENT INFORMATION See Emergency First Aid Treatment Guide ------- EFATG CAS Registry Number: 506-68-3 Page 1 of 3 Emergency First Aid Treatment Guide for CYANOGEN BROMIDE (506-68-3) This guide should not be construed to authorize emergency personnel to perform the procedures or activities indicated or implied. Care of persons exposed to toxic chemicals must be directed by a physician or other recognized authority. Caution: Cyanogen bromide toxicity can occur via ingestion, dermal/eye contact, or inhalation; death may occur within minutes. IMMEDIATELY begin administering 100% oxygen and RUSH victims to a health care facility! Substance Characteristics: Pure Forms - White cubes or needlelike crystals. Odor - Penetrating. Commercial Form - 97% pure solid. Uses - Fumigant, chemical intermediate. Materials to Avoid - Acids, water (except for use in emergency life support). Other Names - Bromine cyanide, Bromocyan, Cyanobromide, TL-822. Personal Protective Equipment: See Chemical Profile Section VIII. Emergency Life-Support Equipment and Supplies That May Be Required: Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium bicarbonate, diazepam, phenytoin. Signs and Symptoms of Acute Cyanogen Bromide Exposure: Warning: Cyanogen bromide may be fatal if inhaled, swallowed, or absorbed through skin or mucous membranes. Caution is advised. Signs and symptoms of acute exposure to cyanogen bromide may include hypertension (high blood pressure) and tachycardia (rapid heart rate), followed by hypotension (low blood pressure) and bradycardia (slow heart rate). Cherry- red or bloody mucous membranes may be noted. Cardiac arrhythmias and other cardiac abnormalities are common. Cyanosis (blue tint to the skin and mucous membranes) may be observed,? ------- EFATG CAS Registry Number: 506-68-3 Page 2 of 3 CYANOGEN BROMIDE Headache, vertigo (dizziness), agitation, and giddiness may be followed by combative behavior, convulsions, paralysis, protruding eyeballs, dilated and unreactive pupils, and coma. Tachypnea (rapid, shallow respirations) or hyperpnea (rapid, deep respirations) may be followed by respiratory depression. Lung hemorrhage and pulmonary edema may also occur. Cyanogen bromide is irritating to the skin, eyes, and mucous membranes. Lacrimation (tearing) and a burning sensation of the mouth and throat are common. Salivation, nausea, and vomiting may also occur. Emergency Life-Support Procedures: Acute exposure to cyanogen bromide may require decontamination and life support for the victims. All exposed persons should be transported to a health care facility as quickly as possible. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to cyanogen bromide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with cyanogen bromide- contaminated persons or their gastric contents can result in self- poisoning. 3. RUSH to a health care facility! 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to cyanogen bromide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin : , - ristering 100% oxygen to all victims. Monitor victims for respiratory cL ------- EFATG CAS Registry Number: 506-68-3 Page 3 of 3 CYANOGEN BROMIDE Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with cyanogen bromide- contaminated persons or their gastric contents can result in self- poisoning. 3. RUSH to a health care facility! 4. Remove contaminated clothing as soon as possible. 5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 6. Wash exposed skin areas twice with soap and water. 7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. IMMEDIATELY begin administering 100% oxygen to all victims. Monitor victims for respiratory distress. Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a forced-oxygen mask. Direct oral contact with cyanogen bromide- contaminated persons or their gastric contents can result in self- poisoning. 2. RUSH to a health care facility! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. DO NOT induce vomiting or attempt to neutralize! 5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. ------- CAS Registry Number: 506-78-5 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY -- CYANOGEN IODIDE CAS Registry Number: 506-78-5 Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 545): Iodine Cyanide; Jodcyan Chemical Formula: CIN Molecular Weight: 152.92 SECTION I -- REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LDlow oral (cat) 18 mg/kg (*NIOSH/RTECS 1985) TPQ: 1,000/10,000 (pounds) RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2)) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Solid Boiling Point: Not Found Specific Gravity (H2O=1): 2.84 (Hawley 1981, p. 295) Vapor Pressure (mmHg): 1 at 25.2°C (Sax 1984, p. 826) Melting Point: 295.7°F, 146.5°C (Hawley 1981, p. 295) Vapor Density (AIR=1): Not Found Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Slightly (Weast 1980, p. C-259) Appearance and Odor: White needles with a very pungent odor (Merck 1983, p. 385). ------- CAS Registry Number: 506-78-5 Page 2 of 4 CYANOGEN IODIDE SECTION III - HEALTH HAZARD DATA OSHA PEL: Not Found ACGIH TLV: (Cyanides) TWA 5.0 mg/m8, as cyanide (skin) (ACGIH 1986-87, P. 14) IDLH: Not Found Other Limits Recommended: Not Found Routes of Entry: Inhalation: No (Merck 1983, p. 385) Skin: Yes (Sax 1984, p. 826, p. 822) Ingestion: Yes (Sax 1984, p. 826, p. 822) Health Hazards (Acute, Delayed, and Chronic): Causes convulsions, paralysis and death from respiratory failure (Merck 1983, p. 385). Highly toxic; strong irritant to eyes and skin (Hawley 1981, p. 295). (Non-Specific -- Cyanide or Cyanide Mixture, Dry): Poisonous, may be fatal if swallowed or absorbed through skin. Contact may cause burns to the skin and eyes. Fire may produce irritating or poisonous gases (DOT 1984, Guide 55). Medical Conditions Generally Aggravated by Exposure: Not Found SECTION IV - FIRE AND EXPLOSION HAZARD DATA Flash Point (Method Used): Not Found Flammable Limits: LEL: Not Found UEL: Not Found Extinguishing Methods: (Non-Specific -- Cyanide or Cyanide Mixture, Dry) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material (DOT 1984, Guide 55). Special Fire Fighting Procedures: (Non-Specific - Cyanide or Cyanide Mixture, Dry) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site (DOT 1984, Guide 55). Unusual Fire and Explosion Hazards: When heated to decomposition, it emits very toxic fumes of nitrogen oxides, cyanide, and iodide (Sax 1984, p. 826). NFPA Flammability Rating: Not Found ------- CAS Registry Number: 506-78-5 Page 3 of 4 CYANOGEN IODIDE SECTION V -- REACTIVITY DATA Stability: Unstable: Not Found Stable: Not Found Conditions to Avoid: Not Found Incompatibility (Materials to Avoid): Phosphorus (Sax 1984, p. 826) Hazardous Decomposition or Byproducts: When heated to decomposition, it emits very toxic fumes of nitrogen oxides, cyanide, and iodide (Sax 1984, p. 826). Hazardous Polymerization: May Occur: Not Found May Not Occur: Not Found Conditions to Avoid: Not Found SECTION VI - USE INFORMATION Taxidermists' preservatives (Hawley 1981, p. 295). Generally for destroying all lower forms of life (Merck 1983, p. 385). SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Steps to be Taken in Case Material is Released or Spilled) (Non-Specific -- Cyanide or Cyanide Mixture, Dry) Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel, place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55). SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. See the introductory information section at the beginning of the profiles for additional information. SECTION IX -- EMERGENCY TREATMENT INFORMATION Signs and Symptoms of Exposure: Can cause death due to respiratory failure (Merck 1983, p. 385). Health effects are similar to cyanides and iodides (Sax 1984, p. 826). Upon ingestion, a bitter, acrid, burning taste is sometimes noted. Other symptoms are anxiety, confusion, dizziness, giddiness, rapid and difficult breathing, palpitations, tightness in chest, unconsciousness, violent convulsions and death (Gosselin 1984, p. HI-127). ------- CAS Registry Number: 506-78-5 Page 4 of 4 CYANOGEN IODIDE SECTION IX (continued) Emergency and First Aid Procedures: (Non-Specific -- Cyanide or Cyanide Mixture, Dry) Move victim to fresh air; call emergency medical care. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Speed in removing material from skin is of extreme importance. Remove and isolate contaminated clothing and shoes at the site. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation (DOT 1984, Guide 55). COMMENTS Sources searched but no information found: NIOSH/OSHA 1978 NFPA 1984 Student 1981 Weiss 1980 CHRIS 1978 Doull 1980 Clayton and Clayton 1981-82 Arena 1979 Encyc Occupat Health and Safety. 1983 Buchel 1983 Farm Chemicals Handbook 1984 Hayes 1982 ------- CAS Registry Number: 509-14-8 Page 1 of 4 EPA CHEMICAL PROFILE Date: October 31, 1985 Revision: November 30, 1987 CHEMICAL IDENTITY - TETRANITROMETHANE CAS Registry Number: 509-14-8 Synonyms: Methane, Tetranitro; NCI-C55947; Tetan; TNM Chemical Formula: CN4O8 Molecular Weight: 196.04 SECTION I - REGULATORY INFORMATION CERCLA (SARA) 1986: Toxicity Value Used for Listing Under Section 302: LC60 inhalation (rat) 0.144 mg/liter/4 hours (*NIOSH/RTECS 1985) TPQ: 500 (pounds) RQ: 10 (pounds) Section 313 Listed (Yes or No): No SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS Physical State: Liquid Boiling Point: 259°F, 126°C (*Merck 1976) Specific Gravity (H2O=1): 1.6380 at 20°C/4°C (*Weast 1979) Vapor Pressure (mmHg): 13 at 25°C (*Patty 1963) Melting Point: 57.6°F, 14.2°C (*Weast 1979) Vapor Density (AIR=1): 6.8 (*Patty 1963) Evaporation Rate (Butyl acetate=l): Not Found Solubility in Water: Insoluble (*Weast 1979) Appearance and Odor: Pale yellow liquid (*Merck 1976) or colorless oily fluid with acrid biting odor (*Patty 1963), causes tears (NIOSH/OSHA 1978, p. 178). ------- CAS Registry Number: 509-14-8 Page 2 of 4 TETRANITROMETHANE SECTION III - HEALTH HAZARD DATA OSHA PEL: T |