740R88101
EPA Chemical Profiles
for
Extremely Hazardous Substances
U.S. Environmental Protection Agency
June, 1988
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EPA CHEMICAL PROFILES
INTRODUCTORY INFORMATION AND FULL PROFILES
TABLE OF CONTENTS
BACKGROUND 1
DISCUSSION OF SECTIONS OF PROFILES 2
PERSONAL PROTECTIVE EQUIPMENT 5
ABBREVIATIONS 11
GLOSSARY 13
REFERENCES 23
PROFILES BY CAS NUMBER*
June 1988
* Chemical Abstracts Service Registry Number.
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EPA CHEMICAL PROFILES: INTRODUCTORY INFORMATION
BACKGROUND
The U.S. Environmental Protection Agency has developed & set of chemical
profile reference documents for use in dealing with Section 302 of Title III
of the Superfund Amendments and Reauthorization Act (SARA). These EPA
profiles contain a summary of publicly available documented information for
chemicals on the EPA list of extremely hazardous substances listed in the
Federal Register, Vol. 52, No. 77, April 22, 1987.
The profiles were originally developed in 1985 for the 402 chemicals
then called "acutely toxic chemicals" under the Chemical Emergency
Preparedness Program. When the list went into law as the list of extremely
hazardous substances, four additional chemicals were included. Forty of the
406 chemicals were subsequently deleted from the list. Profiles are provided
for the 366 chemicals listed in February, 1988, as extremely hazardous
substances. Other chemicals may be added or deleted in the future. The .
profile format was revised and the data were reviewed, augmented, and revised
as appropriate in 1987. The profiles have been reviewed for accuracy and
completeness. However, an exhaustive literature search was not performed for
each chemical, and a review of original citations has not been made. •
A profile is provided for each chemical on the list of extremely
hazardous substances. Profiles are presented in ascending order of Chemical
Abstract Service (CAS) registry numbers. One chemical (generic name:
organorhodium complex) is identified by a premanufacture review notice (PMN)
number and appears first.
The CAS number was used to search the automated Toxicology Data Base
(TDB) or Hazardous Substance Data Bank (HSDB) from the National Library of
Medicine (NLM). If available, TDB/HSDB files were retrieved. Approximately
65 percent of the chemicals were listed in the TDB/HSDB files. For these
chemicals, the TDB/HSDB files provided the main source of information for the
profiles. All data obtained from the TDB/HSDB were indicated by an asterisk
(*) followed by a reference to the TDB/HSDB citation, (e.g., (*Merck 1976)).
For those chemicals without a TDB/HSDB file, a limited number of standard
reference materials was searched. Such references are cited by author, year,
and page number. A master list of references, including the secondary
references cited in TDB/HSDB, has been prepared and may be found in the
Reference Section of this document. The abbreviations used in the profiles
have been defined in a master list and may be found in the Abbreviation
Section. Medical terms not commonly used have been included in a Glossary
Section. Dorland's Medical Dictionary (1974) was used to provide most of the
definitions in the Glossary.
If information was not available for a specific compound but the
chemical could be categorized, then general information about the chemical
category was included. Such information is indicated, for example, by the
notation "Non-Specific -- Organophosphorus Pesticide" or "Non-Specific --
Poisonous Solid, n.o.s.".
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DISCUSSION OF SECTIONS OF PROFILES
Each profile includes chemical identity information and eight sections
containing information on regulations, properties, hazards, uses, and
precautions. Comments on the elements of the profiles are presented below.
Chemical Identity. The name given on the profile is the name used on
the list of extremely hazardous substances (Section 302 of SARA Title III)
and is one of the most common names.
CAS Registry Number. The number is identical to the number listed in
the National Institute of Occupational Safety and Health (NIOSH) Registry of
Toxic Effects of Chemical Substances (RTECS).
Synonyms. Synonyms from TDB/HSDB files are listed without citation.
Synonyms from NIOSH/RTECS (1983) or the Structure and Nomenclature Search
System (SANSS) (1983) , or other sources are referenced. The 9th Collective
Index (CI) name from the SANSS 1983 database was added to each profile when
the 9th CI name was different from the 8th CI name.
Chemical Formula and Molecular Weight. Data from TDB/HSDB or
NIOSH/RTECS (1983) are not cited. Formulas or molecular weights found in
other sources are cited.
Section I -- Regulatory Information. The toxicity value that placed the
chemicals on the list has been included in this section. These toxicity data
were obtained from a screen of the NIOSH/RTECS on-line computer file and are
also cited with an asterisk (*) (e.g., *NIOSH/RTECS 1985). Toxicity data
were not included for chemicals listed on the basis of high production volume
and known toxicity ("Other" chemicals).
Also included are Threshold Planning Quantities (TPQs) and Reportable
Quantities (RQs), as listed in the Final Rule (Federal Register, Volume 52,
Number 77, April 22, 1987).
An indication of whether the chemical is listed under Section 313 of
Title III of SARA is included; if the chemical falls into a chemical category
listed in Section 313, the category is given.
Section II -- Physical/Chemical Characteristics. Physical state (solid,
liquid, or gas) at ambient conditions is listed, as given in the Interim
Final Rule (Federal Register, Vol. 51, No. 221, November 17, 1986); no
reference is cited on the profiles. Other properties are included with
references.
Section III -- Health Hazard Data. Generally, only human data are
reported in the Health Hazard Data section. The following exposure limits
are included, if available:
• Occupational Safety and Health Administration (OSHA)
Permissible Exposure Limits (PELs);
• American Council of Governmental Industrial Hygienists (ACGIH)
Threshold Limit J/alues (TLVs); and
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• Immediately Dangerous to Life and Health (IDLH) levels
developed by N10SH.
The following limits may be listed under Other Limits Recommended, if
available:
• NIOSH recommendations;
• EEGLs (emergency exposure guidance levels);
• SPEGLs (short-term public emergency guidance levels);
• Human carcinogens or suspect carcinogens listed by the ACGIH;
• OSHA carcinogens; and
• NIOSH potential occupational carcinogens.
EEGLs and SPEGLs, developed by the National Research Council of the National
Academy of Sciences, are discussed in more detail in Appendix D of the
Technical Guidance for Hazards Analysis (EPA 1987). An EEGL is defined as an
acceptable concentration for unpredicted, single, short-term emergency
exposure of a defined occupational group (EEGLs have been developed for
military personnel). A SPEGL is defined as an acceptable concentration for
unpredicted, single, short-term, exposure of the general public in
emergencies.
Information on the route of exposure and health hazards often was not
available or only partially available for specific chemicals. Health hazard
data often were not found specific to dose, route of entry or exposure type
(acute, delayed, or chronic). Generic information on the chemical category
was provided, wherever possible, in the absence of information on the
specific chemical.
Section IV -- Fire and Explosion Hazard Data. In the absence of
chemical-specific information, generic information is provided whenever the
chemical could be categorized. National Fire Protection Association (NFPA)
flammability ratings from the NFPA Fire Protection Guide on Hazardous
Materials are included if available.
Section V -- Reactivity Data. In the absence of chemical-specific
information, generic information is provided whenever the chemical could be
categorized.
Section VI -- Use Information. This section includes uses of the
chemical as reported in HSDB or other sources.
Section VII -- Precautions for Safe Handling and Use. Chemical-
specific information often was not available; therefore, generic information
for the chemical category often is presented.
Section VIII -- Protective Equipment for Emergency Situations. This
section contains recommendations for the type of personal protective
equipment to be used. See page 5 for a detailed discussion of personal
protective equipment.
Section IX -- Emergency Treatment Information. This section contains
information on signs and symptoms of poisoning and emergency treatment
information for first responders. Emergency planners may be especially
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interested in references to medical equipment and supplies that could be
useful in case of the accidental release of the extremely hazardous
substance.
Approximately 120 of the revised chemical profiles contain complete
revisions of the emergency treatment information section and have been
retitled the Emergency First Aid Treatment Guide (EFATG). This new section
has been reformatted and contains more detailed guidance for emergency
treatment based on information obtained from the Rocky Mountain Poison
Center's proprietary data base, Poisindex. The order of completion of
EFATG's is being carried out by priority based on considerations of toxicity,
production volume, and availability of specific emergency treatment
information. Revisions of the emergency treatment information sections for
the remaining profiles is underway and will be published as soon as they are
completed. In the meantime, these profiles contain the emergency treatment
information that was originally published in 1986.
Because the emergency treatment information is designed for use by first
responders, references to signs and symptoms of exposure as well as
procedural guidance avoid the use of highly technical medical language.
Signs and symptoms are not distinguished by route of exposure. Emergency
treatment procedures, on the other hand, are presented according to route of
exposure, with emphasis on the inhalation and dermal routes. References to
invasive treatments are limited, since the emergency treatment information is
directed to first responders rather than medical practitioners. First
responders must be aware of particular state and local regulations which
govern the extent of invasive treatment that they may perform.
The Agency for Toxic substances and Disease Registry (ATSDR) has
provided general review of the EFATf-'s for format and content.
Comments. This section is provided, in some cases, to list the sources
that were checked for information in cases of chemicals for which few data
were available. In general, this section pertains to chemicals without
TDB/HSDB files.
Not Found. This statement on the profile can mean that:
• The value or information was not found in the references used;
• The value or information probably does not exist for this
chemical; or
• The value is meaningless or not applicable for this chemical.
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PERSONAL PROTECTIVE EQUIPMENT
Personal protective equipment (PPE) for emergency response situations
involving extremely hazardous substances must be selected carefully and used
properly. The PPE should protect the respiratory system, skin, eyes, face,
hands, feet and body from chemical, physical and biological hazards that may
be encountered during an emergency response action. Selection of the proper
personal protective equipment must consider the specific hazards responders
are likely to encounter at a particular site. Selection is a complex task
and should be performed only by individuals with proper training and
experience.
Regulatory Requirements and Other Standards. Selection, use, training
and programs for PPE for emergency response situations may be covered by
regulations and standards under the Occupational Safety and Health
Administration (OSHA) 29 CFR 1910, Environmental Protection Agency (EPA)
regulations and recommendations, Department of Transportation (DOT)
regulations, or National Fire Protection Association (NFPA) standards.
Personal Protective Equipment for Emergencies. During an emergency
involving extremely hazardous substances, a wide variety of conditions may
occur. Therefore, response personnel should wear maximum protection
initially until actual conditions at the site are evaluated. Maximum
protection is designed to provide the highest available level of respiratory,
skin and eye protection. Recommended equipment consists of a positive
pressure, pressure-demand full facepiece self-contained breathing apparatus
(SCBA) or full facepiece supplied air respirator with escape SCBA and a
fully-encapsulating chemical-resistant suit. In addition, other equipment
such as inner chemical-resistant gloves, chemical-resistant safety
boots/shoes, and two-way radio communications, a cooling unit, coveralls,
long cotton underwear, hard hat, disposable gloves and boot covers may be
worn as needed.
Figure 1 gives an example of a worker outfitted in a fully-
encapsulating suit with respiratory protection. Note that if the fully-
encapsulating suit does not have integral gloves and boots, then glove/suit
and boot/suit joints should be sealed with tape.
Respiratory Protection. Positive pressure self-contained breathing
apparatus (SCBA) should be worn by employees engaged in emergency response
and exposed to hazardous substances until it is determined that a decreased
level of respiratory protection will not result in hazardous exposures to
employees (See OSHA 29 CFR 1910.120 Hazardous Waste Operations and Emergency
Response).
Chemical Protective Clothing and Equipment. The selection of chemical
protective clothing is a complex process and many factors must be considered
such as: the nature of the hazard; the potential route of exposure; the
tasks to be accomplished; and the performance of the protective equipment
materials in forming a barrier to the chemical substances encountered at a
site. No protective equipment material protects against all chemicals and
combinations of chemicals. In many cases, the chemical substance may
permeate or break through the protective equipment;material, exposing the
wearer to the chemical. It is important to note that the information
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Figure 1. FULLY ENCAPSULATING CHEMICAL-RESISTANT SUI
Respiratory Protection Must be Worn with this Type of S
From "Guidelines for the Selection of Chemical Protective C!
3rd Edition.
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presented for an individual chemical may not be applicable when that chemical
is present in a mixture, as the ability of a chemical in a mixture to
permeate a material may differ from that of the pure chemical. Further
studies are needed to evaluate the characteristics of mixtures of chemicals
in relation to materials for personal protective equipment.
The chemical profiles give general information on the chemical
resistance of various suit materials to provide a basis for a decision on
whether suit materials are adequate. This information is available for about
half of the chemicals on the list of extremely hazardous substances. The
chemical resistance information for each suit material is indicated on the
profiles by the entries shown below. Explanations of their meanings follow
the entries.
• Excellent Resistance/Many Data means there is quantitative
information indicating that the material demonstrates
excellent chemical resistance to the substance.
• Good Resistance/Limited Data means there is quantitative
information indicating that the material demonstrates good
chemical resistance to the substance.
• Poor Resistance/Many Data means there is quantitative
information indicating that the material demonstrates poor
chemical resistance to the substance.
• Poor Resistance/Limited Data means there is quantitative
information indicating that the material demonstrates poor
chemical resistance to the substance.
• Good Resistance/Limited Data* means there is qualitative
information indicating that the material demonstrates good
chemical resistance to the substance. Most of this
information is based on qualitative ratings from glove
material manufacturers and may or may not be based on actual
testing. This entry on the profile is intended to provide
general guidance in selecting chemical protective clothing.
• Poor Resistance/Limited Data* means there is qualitative
information indicating that the material demonstrates poor
chemical resistance to the substance. Most of this
information is based on qualitative ratings from glove
material manufacturers and may or may not be based on actual
testing. This entry on the profile is intended to provide
general guidance in selecting chemical protective clothing.
• Good Resistance/Limited Data** means there is qualitative or
quantitative information indicating that the material
demonstrates good chemical resistance based on the generic
family of chemicals to which the substance belongs. Most of
this information is not based on testing done on the substance
itself. This entry on the profile is intended to provide
general guidance to the initial selection of chemical
protective clothing and to narrow the scope of alternative
materials.
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• Poor Resistance/Limited Data** means there is qualitative or
quantitative information indicating that the material
demonstrates poor chemical resistance based on the generic
family of chemicals to which the substance belongs. Most of
this information is not based on testing done on the substance
itself. This entry on the profile is intended to provide
general guidance to the initial selection of chemical
protective clothing and to narrow the scope of alternative
materials.
Remember that this information provides guidance only and is not a
guarantee that the suit will protect an individual from prolonged or repeated
exposure and may not provide adequate protection for mixtures of chemicals.
Consult reference 1 for more information. Also, be sure to consult with
facility representatives for additional information. Other considerations
include durability and flexibility of the chemical protective clothing, and
heat stress. Table 1 lists the fully-encapsulating suit materials available
on the market as of February, 1987. (See non-mandatory Appendix B of OSHA 29
CFR 1910.120 for more information).
Special Use Considerations. Fire, heat, explosion and radiation require
special-protective equipment. It is important to provide protection from
these hazards in addition to chemical hazards. Section IV of the profiles
entitled Fire and Explosion Hazard Data should be consulted for further
information. (See OSHA 29 CFR 1910.156, DOT and NFPA standards and
recommendations for more information.)
Decontamination. Decontamination of personal protective equipment
should be tailored to the specific conditions at the site and will vary
accordingly. (See non-mandatory Appendix D of OSHA 29 CFR 1910.120 for
additional information).
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TABLE 1. AVAILABLE FULLY-ENCAPSULATING SUIT MATERIALS
AS OF FEBRUARY, 1987*
1. Butyl Rubber/Nylon (BUTYL)
2. Butyl Rubber, Sheet (BUTYL)
3. Butyl/Fabric/Butyl (BUTYL)
4. Butyl/Nylon/Butyl (BUTYL)
5. Butyl/Polyester/Chloroprene Rubber (BUTYL/NEOPRENE)
6. Chlorinated Polyethylene (CPE)
7. Chlorobutyl Rubber/Nomex (CHLOROBUTYL)
8. Chlorobutyl/Nomex/Chlorobutyl (CHLOROBUTYL)
9. Chloroprene Rubber/Nylon (NEOPRENE)
10. Chloroprene Rubber, Sheet (NEOPRENE)
11. Fluoroelastomer/Butyl/Nylon/Butyl (VITON/BUTYL)
12. Fluoroelastomer/Fabric/Fluoroelastomer (VITON)
13. Fluoroelastomer/Nylon/Chloroprene (VITON/NEOPRENE)
14. Fluoroelastomer/Polyester/Chlorobutyl (VITON/CHLOROBUTYL)
15. Fluoroelastomer, Sheet (VITON)
16. Nitrile/Fabric (NITRILE)
17. PE/Polyvinylidenechloride/PE/Tyvek (SARANEX)
18. Polyethylene/Tyvek (PE)
19. Polyvinyl Chloride/Fabric (PVC)
20. Polyvinyl Chloride/Fabric/Polyvinyl Chloride (PVC)
21. Polyvinyl Chloride/Nylon (PVC)
22. Polyvinyl Chloride/Nylon/Polyvinyl Chloride (PVC)
23. Polyvinyl Chloride, Sheet (PVC)
24. Sontara (NONWOVEN FABRIC)
25. TFE/Fiberglass/TFE (TEFLON)
26. TFE/Nomex/TFE (TEFLON)
27. Tyvek (NONWOVEN PE)
Schwope, A.D., et al. Guidelines for the Selection of Chemical
Protective Clothing, 3rd Edition. Cincinnati: American Conference of
Governmental Industrial Hygienists, Inc., 1987.
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PERSONAL PROTECTIVE EQUIPMENT REFERENCES
1.1 Schwope, A.D. ; P.P. Costas; J.O. Jackson; J.O. Stull; and D.J. Weitzman.
Guidelines for the Selection of Chemical Protective Clothing. 3rd
Edition. Cincinnati: American Conference of Governmental Industrial
Hygienists, Inc., 1987.
2. Certified Equipment List as of October 1, 1986. DHHS (NIOSH) No. 87-
102. Cincinnati: National Institute for Occupational Safety and
Health, 1986.
3. Criteria for a Recommended Standard ... Occupational Exposure to Hot
Environments Revised Criteria 1986. DHHS (NIOSH) No. 86-113.
Cincinnati: National Institute for Occupational Safety and Health,
1986.
4. National Institute for Occupational Safety and Health; Occupational
Safety and Health Administration; U.S. Coast Guard; U.S. Environmental
Protection Agency. Occupational Safety and Health Guidance Manual for
Hazardous Waste Site Activities. DHHS Occupational Safety and Health,
1985.
5. Occupational Safety and Health Administration 29 CFR 1910 Occupational
Safety and Health Standards, especially 29 CFR 1910.120 Hazardous Waste
Operations and Emergency Response.
6. National Fire Protection Association standards and recommendations, such
as NFPA 704M, 1500 and 1981.
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ABBREVIATIONS
ACGIH
ADI
AIHA
BAL
GAS
CC
CNS
EEC
EEGL
EKG
EPA
IARC
ID1H
1m
LCLO
LC50
LDLO
LD50
T,ET,
m3
mg/Kg
nnnHg
NIOSH
n.o.s.
American Conference of Government and Industrial Hygienists
Acceptable Daily Intake
American Industrial Health Association
Dimercaprol (British anti-lewisite)
Chemical Abstracts Service
Closed cup
Central Nervous System
Electroencephalogram
Emergency Exposure Guidance Level developed by the National
Research Council (NRC)
Electrocardiogram
Environmental Protection Agency
International Agency for Research on Cancer
Immediately Dangerous to Life and Health
intramuscularly
Lethal Concentration Low; the lowest concentration at which
death occurred
Lethal Concentration 50; the concentration at which 50% of the
animals died; a calculated value
Lethal Dose Low; the lowest dose at which death occurred
Lethal Dose 50; the dose at which 50% of the animals died; a
calculated value
Lower Explosive Limit
Cubic meter
milligrams per kilogram
millimeters of mercury; a measure of pressure
National Institute of Occupational Safety and Health
Not otherwise specified
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NRG
NTP
OC
OSHA
PEL
ppb
ppm
RBC
RTECS
SANSS
SPEGL
STEL
TCC
TOG
TDLO
TLV
TWA
DEL
ug
2-PAM
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ABBREVIATIONS (Confd)
National Research Council, National Academy of Sciences
National Toxicology Program
open cup
Occupational Safety and Health Administration
Permissible Exposure Level
parts per billion
parts per million
Red blood cell(s)
Registry of Toxic Effects of Chemical Substances
Structure and Nomenclature Search System
Short-term Public Exposure Guidance Level developed by the NRC
Short-term exposure limit
Tagliabue Closed Cup, a standard method of determining flash
point
Tagliabue Open Cup, a standard method of determining flash
point
Toxic Dose Low; the lowest dose at which toxicity occurred
Threshold Limit Value
Time Weighted Average
Upper Explosive Limit
microgram
pralidoxime
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GLOSSARY
Acaricide
Acidosis
Acneform
Albuminuria
Alopecia
Amorphous
Anaphylactoid
Anorexia
Anoxia
Anthelmintic
Anticoagulant:
Antilewisite
Antimetabolite
Antipyretic
Aphasia
Aplasia
Ar gyrosis
an agent that destroys mites
pathologic condition resulting from
accumulation of acid in, or loss of base
from, the blood or body tissues
resembling acne
presence of serum albumin in the urine
baldness; absence of hair from skin areas
where it is usually present
without definite form, not crystallized
resembling an unusual or exaggerated
allergic reaction to foreign protein or
other substances
lack or loss of appetite for food
absence of lack of oxygen; reduction of
oxygen in the body tissues below
physiologic levels
an agent that is destructive to worms
especially of the intestine
an agent that prevents blood clotting
dimercaprol; also called British anti-
lewisite, or BAL
a substance that interferes with
utilization of an essential metabolite
an agent that relieves or reduces fever
defect or loss of power of expression by
or comprehension of speech, writing, or
signs
lack of development of an organ or tissue,
or the cellular products from an organ or
tissue; germinal aplasia -- complete
failure of gonad development
poisoning by silver or a silver salt,
evidenced by ashen-gray discoloration of
skin
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GLOSSARY (Cont'd)
Arrhythmia
Arteriosclerosis
Asthenia
Astringent
Ataxis
Avicide
Bioaccumulation
Bradycardia
Bronchoconstriction
Calcification
Carcinogenic
Cardiac
Cathartic
Cheyne -Stokes respiration
Chloracne
Clonic
Conj unct ivitis
Contraindication
any variation from the normal rhythm of
the heart beat
hardening and thickening of the walls of
the smaller arteries
lack or loss of strength; weakness
causing contraction, usually locally after
surface application
failure of muscular coordination;
irregularity of muscular action
an agent that kills birds
increased concentrations of a chemical in
an organism compared to the surrounding•
environment
slowness of the heart beat, as evidenced
by slowing of pulse rate to less than 60
narrowing of the air passages of the lungs
process by which organic tissue becomes
hardened by a deposit of calcium salts
within its substance
producing or inciting cancer
pertaining to the heart
causing evacuation of the bowels; laxative
respiratory distress related to posture
(especially reclining at night) that
occurs in association with heart disease
acne-like eruption caused by exposure to
chlorine compounds
pertaining to alternate muscular
contraction and relaxation in rapid
succession
inflammation of the lining of the eyelids
any condition which renders some
particular line of treatment improper or
undesirable
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GLOSSARY (Cont'd)
Cryogenic
Cyanosis
Decoction
Demulcent
Dermal
Dermatitis
Desiccant
Diluent
Diuresis
Diuretic
DS2
Ductile
Dyspnea
Ectoparasiticide
Edema
Ernesis
Enteritis
Epigastric
Epileptiform
Epithelium
pertaining to or causing the production of
low temperatures
bluish discoloration, especially of the
skin and mucous membranes and fingernail
beds
substance prepared by boiling
soothing
pertaining to the skin
inflammation of the skin
a drying agent
a diluting agent
increased secretion of urine
agent that increases urine production
standard decontaminant for chemical
warfare agents; contains 70% diethylene
triamine, 28% ethylene glycol monomethyl
ether, and 2% sodium hydroxide
capable of being drawn out or hammered
thin
difficult or labored breathing
an agent that kills parasites living on
the exterior of its host
presence of abnormally large amounts of
fluid in intercellular spaces of body
tissues
vomiting
inflammation of the intestine
pertaining to the upper-middle region of
the abdomen
occurring in severe or sudden spasms
cells covering the internal and external
surfaces of the body
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GLOSSARY (Cont'd)
Erythema
Exothermic
Explosive
Flammable
Gastrointestinal
Germinalaplasia
Glomerular
Half-life
Halon
Health Hazard
Acute
Chronic
Delayed
Hematoma
Hematuria
Hemoglohinuria
Hemolysis
Hemolytic
Hepatic
redness of the skin produced by congestion
of the capillaries
characterized by or formed with evolution
of heat
characterized by or relating to bursting
forth with sudden violence or noise from
internal energy; relating to a rapid
reaction with production of noise, heat,
and violent expansion of gases
capable of being easily ignited and
supporting combustion
pertaining to the stomach and intestine
lack of development of egg and sperm cells
pertaining to a tuft or cluster, as of
blood vessels or nerve fibers
the time in which the concentration of a
substance will be reduced by half
halogenated hydrocarbon (e.g., carbon
tetrachloride)
immediate toxic effects
persistent or prolonged injury
toxic effect occurring after a lapse of
time
localized collection of blood, usually
clotted, in an organ, space, or tissue,
due to a break in the wall of the blood
vessel
blood in the urine
presence of free hemoglobin in the urine
separation of hemoglobin from red blood
cells and its appearance in the plasma
pertaining to or characterized by
hemolysis
pertaining to the liver
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GLOSSARY (Cont'd)
Humectant
Hydrolysis
Hygroscopic
Hyperactivity
Hyperalimentation
Hyperbilirubinemia
Hypercalcemia
Hyperparathyroidism
Hyperpyrexia
Hyperreflexia
Hypersalivation
Hypertens ion
Hypervitaminosis
Hypobilirubinemia
Hypocalcemia
Hypovolemic
Hypoxemia
Hypoxia
Interstitial Pneumonia
moistening or diluent substance
decomposition reaction involving the
splitting of a chemical substance by water
readily taking up and retaining moisture
(water)
abnormally increased activity
ingestion or administration of a greater
than optimal amount of nutrients
an excess of bilirubin in the blood
excess of calcium in the blood
abnormally increased activity of the
parathyroid glands which affects and is
affected by serum calcium levels
a highly elevated body temperature
exaggeration of reflexes
excessive secretion of saliva
persistently high arterial blood pressure
condition due to ingestion of an excess of
one or more vitamins
abnormally low levels of bilirubin in the
blood
abnormal reduction of blood calcium levels
pertaining to an abnormally decreased
volume of circulating fluid (plasma) in
the body
deficient oxygenation of the blood
low oxygen content or tension; deficiency
of oxygen in the inspired air
a chronic form of pneumonia with increase
of the interstitial tissue and decrease of
the proper lung tissue
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GLOSSARY (Cont'd)
Isotonia
Jaundice
Lachrymator (or lacrimator)
Lacrimation
Laryngospasm
Larynx
Lassitude
Latency
Lesion
Lethal
Leukopenia
Lewisite
Malaise
Mania
Metastatic
Methemoglobinemia
Miosis (or myosis)
a solution having the same effective
osmotic pressure as the body fluid to
which it is compared
syndrome characterized by
hyperbilirubinemia and deposition of bile
pigment in the skin, resulting in yellow
appearance of the patient
a substance which increases the flow of
tears
secretion and discharge of tears
spasmodic, closure of the larynx
the muscular and cartilage structure
situated at the top of the trachea
(windpipe) and below the root of the
tongue, functioning as sphincter into the
trachea and as the organ of voice
weakness; exhaustion
a state of seeming inactivity
a pathological or traumatic discontinuity
of tissue or loss of function of a part
deadly; fatal
reduction in the number of leukocytes in
the blood
a lethal war gas which is a vesicant,
lacrimator and lung irritant
a vague feeling of bodily discomfort
a phase of mental disorder characterized
by an expansive emotional state, elation,
overtalkativeness, and increased motor
activity
pertaining to the transfer of disease from
one organ or part to another not directly
connected with it
presence of methemoglobin (oxidized
hemoglobin) in the blood
contraction of the pupil
-------
-19-
GLDSSARY (Cont'd)
Miscible
Mordant
Mutagenic
Mydriasis
Myelosuppression
Narcotic
Necrosis
Nephritis
Neural
Neuropathy
Neurotoxicity
Nocturia
Ocular
Oliguria
Ophthalmic
Osteosclerosis
Palpitation
Parasympathomimetic
capable of mixing in any ratio without
. separation of two phases
a chemical that fixes a dye in or on a
substance by combining with the dye to
form an insoluble compound
inducing genetic mutation
extreme dilation of the pupil
suppression of the formation of bone
marrow
an agent that produces insensibility or
stupor
death of tissue, usually as individual
cells, group of cells, or in localized
areas
inflammation of the kidney
pertaining to a nerve or to the nerves
functional disturbances and/or
pathological changes in the peripheral
nervous system
exerting a destructive or poisonous effect
en nerve tissue
excessive urination at night
pertaining to or affecting the eye
secretion of a diminished amount of urine
in relation to fluid intake
pertaining to the eye
hardening or abnormal density of bone
unduly rapid heart beat which is noted by
the patient; it may be regular or
irregular
producing effects resembling time of
stimulation of the parasympathetic nerve
supply to a part; called also cholinergic
-------
-20-
GLOSSARY (Cont'd)
Parenteral
Paresthesia
Perfusion
Pharynx
Photophobia
Photosens itize
Phytotoxic
Polydipsia
Precordial
Proteinuria
Psychosis
Psychotropic
Pulmonary
Rales
Recumbent
Renal
Scotoma
not through the alimentary canal but
rather by injection through some other
route, such as subcutaneous,
intramuscular, intravenous, etc.
an abnormal sensation, as burning or
prickling
liquid poured over or through an organ or
tissue
the muscular membrane sac between the
mouth and nostrils and the esophagus
abnormal visual intolerance of light
to induce a state of abnormal
responsiveness to the influence of light
poisonous to plants; inhibiting plant
growth
excessive thirst persisting for long
periods of time
pertaining to the region over the heart
and lower part of the thorax
an excess of serum proteins in the urine;
also called albuminuria
any major mental disorder characterized by
derangement of the personality and loss of
contact with reality
exerting an effect upon the mind; capable
of modifying mental activity
pertaining to the lungs
abnormal respiratory sound heard when
listening for sounds within the body
lying down
pertaining to the kidney
an area of depressed vision within the
visual field, surrounded by an area of
less depressed or normal vision
-------
-21-
GLOSSARY (Cont'd)
Supertropical Bleach
Systemic
Tachycardia
Tepid
Teratogenic
Tetanic
Thrombocytopenia
Tidal volume
Tinnitus
Toxic
Triglyceridemia
Urticaria
Vasodilation
Ventrictilar fibrillation
Vertigo
bleaching agent containing calcium
hypochlorite (a powerful oxidizer) and
calcium oxide (a corrosive material)
pertaining to or affecting the body or
organism as a whole
excessively rapid heart beat
moderately warm; lukewarm
tending to produce anomalies of formation
or development
pertaining to or of the nature of tetanus,
a disease characterized by muscle spasm
decrease in the number of blood platelets
amount of gas that is inhaled and exhaled
during one respiratory cycle
a noise in the ears, such as ringing,
buzzing, roaring, clicking
pertaining to, due to, or of the nature of
a poison
excess of triglycerides in the blood
a vascular reaction of the skin marked by
the transient appearance of smooth,
slightly elevated patches (wheals) which
are redder or paler than the surrounding
skin and often attended by severe itching
dilation (expansion of a vessel,
especially of arterioles leading to
increased blood flow to a part
irregular heart beat characterized by
uncoordinated contractions of the
ventricle
dizziness; an illusion of movement as if
the external world were revolving around
an individual or as if the individual were
revolving in space
Vesicant
causing blisters
-------
-22-
GLOSSARY (Conf d)
Volatile -- readily vaporizable at a relatively low
temperature
-------
-23-
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-------
-24-
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-25-
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-26-
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* NIOSH. 1976. National Institute for Occupational Safety and Health,
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* NIOSH. 1975. National Institute for Occupational Safety and Health,
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Center for Disease Control. Registry of toxic effects of chemical
substances. 1975 ed. Washington, D.C.: U.S. Government Printing
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* NIOSH, 1974. National Institute for Occupational Safety and Health,
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* NIOSH. 1973. National Institute for Occupational Safety and Health,
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Stricoff RS, Partridge LJ, Jr., eds. NIOSH/OSHA pocket guide to
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/- NIOSH/OSHA. 1978. National Institute for Occupational Safety and
Health/Occupational Safety and Health Administration, U.S. Department of
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-------
-35-
REFERENCES (Cont'd)
/- NIOSH/RTECS. 1987. National Institute for Occupational Safety and
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* NIOSH/RTECS. 1985. National Institute for Occupational Safety and
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/- NRC. 1984b. National Research Council. Emergency and continuous
exposure limits for selected airborne contaminants, Vol. 2. Washington,
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/- NRC. 1984c. National Research Council. Emergency and continuous
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/- NRC. 1985a. National Research Council. Emergency and continuous
exposure limits for selected airborne contaminants, Vol. 4. Washington,
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exposure limits for selected airborne contaminants, Vol. 5. Washington,
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exposure limits for selected airborne contaminants, Vol. 6. Washington,
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/- NRC. 1987. National Research Council. Emergency and continuous
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* NRC. 1983. National Research Council. Drinking water and health, Vol.
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* NRC. 1982. National Research Council. Drinking water and health, Vol.
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-------
-36-
REFERENCES (Cont'd)
* NRC. 1983. National Research Council. Polycyclic aromatic
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* NRC. 1981. National Research Council. Prudent practices for handling
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* NRC. 1980a. National Research Council. Drinking water and health,
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* NRC. 1980b. National Research Council. Drinking water and health,
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* Opavsky W, MacPherson E. 1976. Ger Offen Patent Number 2430193,
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*/- OSHA. 1984. Occupational Safety and Health Administration, U.S.
Department of Labor. Occupational safety and health standards. Subpart
Z. Toxic and hazardous substances. (29 CFR 1910..1000). pp. 660-665.
* Osol A, ed. 1980. Remington's pharmaceutical sciences. 16th ed.
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Philadelphia: J.B. Lippincott.
* Parke DV. 1968. The biochemistry of foreign compounds. Oxford:
Pergamon Press.
* Parr JF, Marsh PB, Kla JM, eds. 1983. Land treatment of hazardous
wastes. Park Ridge, NJ: Noyes Data Corporation.
* Patty F, ed. 1963. Industrial hygiene and toxicology: Vol II:
toxicology. 2nd ed. New York: Interscience Publishers.
-------
-37-
REFERENCES (Cont'd)
Peer Review Committee. Updated 1985. Expert opinion on Data Base.
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Perry R.H., ed. 1984. Perry's Chemical Engineer's Handbook. 6th ed.
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Physicians' Desk Reference. 1980, 1985. 34th ed. and 39th ed.
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Economics Co.
Proctor NH, Hughes JP. 1978. Chemical hazards of the workplace.
Philadelphia: J.B. Lippincott Co.
Roberts NJ. 1983. South Med. J. 76(1)45-48.
Rodricks JV, Hesseltine CW, Mehlman MA, eds. 1977. Mycotoxins in human
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Rossoff IS. 1974. Handbook of veterinary drugs. New York: Springer
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Rumack BH, ed. 1975-Present. Poisindex. Microfiche ed. Denver, CO:
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SANSS. 1983. Structure and Nomenclature Search System. Chemical
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update November 1983.
Sax NI, ed. 1986. Rapid guide to hazardous chemicals in the workplace.
New York: Van Nostrand Reinhold Co.
Sax NI. 1984. Dangerous properties of industrial materials. 6th ed.
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Sax NI. 1979. Dangerous properties of industrial materials. 5th ed.
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Sax NI. 1975. Dangerous properties of industrial materials. 4th ed.
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Sax NI. 1968. Dangerous properties of industrial materials. 3rd ed.
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Schuckmann, F. 1972. Zentralarbeitsmed Arbeitsschutz 22(3):74.
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American Chemical Society. ACS Monograph 173.
-------
-38-
REFERENCES (Cont'd)
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Soliman et al. 1979. J. Environ Sci Health, Part B B14(l)27.
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Spencer EY. 1973. Guide to the chemicals used in crop protection, 6th
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SRI. 1983. Standard Research Institute International. 1983 Directory
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Sunshine I, ed. 1969. CRC handbook of analytical toxicology.
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-------
-39-
REFERENCES (Cont'd)
/- U.S. Army. 1975. Headquarters, Department of the Army. Military
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* Usdin E, Efron DH. 1972. Psychotropic drugs and related compounds.
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* USEPA. 1980. U.S. Environmental Protection Agency. Ambient Water
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033).
* USEPA/ECAO. 1980. U.S. Environmental Protection Agency/Environmental
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* USEPA/ODW. 1983. U.S. Environmental Protection Agency. Office of
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/- USEPA/Pesticide Index. 1985. U.S. Environmental Protection Agency.
EPA Index to Pesticide Chemicals: Use and Limitations. Current file;
updated daily. Washington, D.C.: Office of Pesticide Programs, USEPA.
/- USEPA/Active Ingredients. 1985. U.S. Environmental Protection Agency.
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* USFWS. 1984. U.S. Fish and Wildlife Service, Department of the
Interior. Handbook of toxicity of pesticides to wildlife. Washington,
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* USFWS. 1980. U.S. Fish and Wildlife Service, Department of the
Interior. Handbook of acute.toxicity of chemicals to fish and aquatic
invertebrates. Washington, D.C.: U.S. Government Printing Office.
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* USFWS. 1975. U.S. Fish and Wildlife Service, Department of the
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* USFWS. 1972. U.S. Fish and Wildlife Service, Department of the
Interior, Bureau of Sports Fisheries and Wildlife. Comparative dietary
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Printing Office. Special Scientific Report -- Wildlife No. 152.
-------
-40-
REFERENCES (Confd)
*-. USFWS. 1970. U.S. Fish and Wildlife Service, Department of the
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Champaign, IL: Weed Science Society of America.
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New York: Marcel Dekker.
-------
-41-
REFERENCES (Conf d)
* White-Stevens R, ed. 1976b. Pesticides in the environment: Vol 2.
New York: Marcel Dekker.
* White-Stevens R, ed. 1971. Pesticides in the environment: Vol 1. Part
1, Part 2. New York: Marcel Dekker.
*/- Worthing CR, Walker SB, eds. 1983. The pesticide manual -- a world
compendium. 7th ed. Lavenham, Suffolk, Great Britain: The Lavenham
Press Limited.
*. Worthing CR, ed. 1979. Pesticide manual. 6th ed. Worcestershire,
England: British Crop Protection Council.
/- Worthy-W. 1985. Methyl isocyanate: the chemistry of a hazard. Chem
Eng News 63(6):27-33.
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CAS Registry Number: 50-00-0
Page 5 of 5
FORMALDEHYDE
SECTION VIII (continued)
SUIT MATERIAL.PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl EXCELLENT/MANY
Butyl/Neoprene GOOD/LIMITED*
CPE GOOD/LIMITED
Neoprene POOR/MANY
Nitrile POOR/MANY
PE EXCELLENT/MANY
PVC POOR/MANY
Teflon POOR/LIMITED
Viton EXCELLENT/MANY
Viton/Neoprene GOOD/LIMITED*
*Based on qualitative performance information.
**Based on a chemical analog.
NOTES: For concentrations <37% formaldehyde
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 50-00-0
Page 1 of 3
Emergency First Aid Treatment Guide
for
FORMALDEHYDE
(50-00-0)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Colorless gas or liquid below -20 degrees C (-6 degrees F).
Odor - Strong, pungent.
Commercial Form - Aqueous solution containing approximately 40% formaldehyde
and 15% methanol.
Uses - Disinfectant, preservative, embalming fluid, treatment of grain smut,
hardening agent, reducing agent, corrosion inhibitor, gold and silver recovery,
textile manufacture.
Other Names - Formalin, formic aldehyde, Formol, Karsan, Lysoform, methanal,
methyl aldehyde, methylene oxide, Morbicid, oxomethane, oxymethylene.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, syrup of Ipecac,
activated charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's
lactate, sodium bicarbonate, dopamine, norepinephrine, levarterenol.
-------
EFATG
CAS Registry Number: 50-00-0
Page 2 of 3
FORMALDEHYDE
Signs and Symptoms of Acute Formaldehyde Exposure:
Acute exposure to formaldehyde may result in irritation or burns to the skin,
eyes, and mucous membranes; lacrimation (tearing); nausea; vomiting (may be
bloody); abdominal pain; and diarrhea. Difficulty in breathing, cough,
pneumonia, and pulmonary edema may occur. Sensitized people may experience
asthmatic reactions, even when exposed briefly. Hypotension (low blood
pressure) and hypothermia (reduced body temperature) may precede cardiovascular
collapse. Lethargy, dizziness, convulsions, and coma may be noted. Nephritis
(inflammation of the kidneys), hematuria (bloody urine), and liver toxicity
have been reported.
Emergency Life-Support Procedures:
Acute exposure to formaldehyde may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to formaldehyde.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to formaldehyde.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least IS minutes.
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EFATG
CAS Registry Number: 50-00-0
Page 3 of 3
FORMALDEHYDE
5. Wash exposed skin areas twice with soap and water,
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims
are conscious and alert.
4. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of formaldehyde is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 5. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of formaldehyde may result in sudden onset of seizures
or loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainty exists, proceed to Step 5.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities'of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
5. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of
cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
7. Transport to a health care facility.
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CAS Registry Number: 50-07-7
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- MITOMYCIN C
CAS Registry Number: 50-07-7
Synonyms: Ametycine; Mutamycin; NSC-26980; Azirino[2',3':3,4]pyrrolo
[l,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-l,la,2,8,8a,8b-
hexahydro-8a-methoxy-5-methyl-,[laR-(la.alpha.,8.beta.,8a.alpha.,8b.alpha.)]-
Chemical Formula: C15H18N4O5
Molecular Weight: 334.37
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (rat)
14 rag/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds) (statutory); 10 (pounds) (proposed)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Above 680°F, 360°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Merck 1983)
Appearance and Odor: Blue-violet crystals (*Merck 1983)
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CAS Registry Number: 50-07-7
Page 2 of 3
MITOMYCIN C
i
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Toxic doses as low as 750
rag/kg have been reported in humans (*NIOSH 1979). The major toxic effect
is myelosuppression, characterized by marked leukopenia and
thrombocytopenia; this may be delayed and cumulative. Interstitial
pneumonia and glomerular damage resulting in kidney failure are unusual but
well documented complications (Oilman 1985, p. 1289).
Medical Conditions Generally Aggravated by Exposure: Lung conditions —
administration of mitomycin has been recognized as causing pneumonitis,
alveolitis and pulmonary fibrosis (*Weiss 1980). Kidney conditions --
administration of mitomycin can cause kidney damage (Oilman 1985, p. 1289).
Kidney toxicity was observed in 1-5 percent of patients. Depressed immune
conditions (*AMA 1977).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
- Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
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CAS Registry Number: 50-07-7
Page 3 of 3
MITOMYCIN C
SECTION V (continued)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Anti-tumor antibiotic complex (*Merck 1976). This drug is usually injected
intravenously (*AMA 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact.
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Headaches, blurred vision, confusion,
drowsiness, fatigue, diarrhea, and pain have been occasionally noted.
These do not appear to be dose related by intravenous administration.
Fever and anorexia occur in 15 percent of patients. Hair loss, sloughing
of skin, and loss of feeling occur in approximately 4 percent of patients.
Labored breathing, cough and pneumonia occur in some cases. Renal toxicity
is sometimes observed (*AMA 1977).
Emergency and First Aid Procedures: Seek immediate medical care. Skin
decontamination should be thorough, with water and soap. Eye exposure can
be followed by irrigation of eyes with plain tap water (*Rumack 1975 to
Present). (Non-Specific - Medicines, n.o.s.) If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. Remove
and isolate contaminated clothing and shoes at the site. Keep victim quiet
and maintain normal body temperature (DOT 1984, Guide 11).
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CAS Registry Number: 50-14-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ERGOCALCIFEROL
CAS Registry Number: 50-14-6
Synonyms: 9,10-Secoergosta-5,7,10(19),22-Tetraen-3-beta-ol;
9,10-Secoergosta-5,7,10( 19),22-Tetraen-3-ol,(3-beta,5Z,7E,22E)-; Activated
Ergosterol; Buco-D; Calciferol; Calciferon 2; Condacaps; Condocaps; Condol;
Crtron; Crystallina; D-Arthin; D-Tracetten; Daral; Davitamon D; Davitin; De-Rat
Concentrate; Decaps; Dee-Osterol; Dee-Ron; Dee-Ronal; Dee-Roual; Deltalin;
Deratol; Detalup; Diactol; Divit Urto; Doral; Drisdol;
Ergorone; Ergosterol Activated; Ergosterol, Irradiated; Ertron; Fortodyl;
Geltabs; Hi-Deratol; Infron; Irradiated Ergosta-5,7,22-Trien-
3-Beta-ol; Irradiated Ergosterol; Metadee; Mina D2; Mulsiferol; Mykostin;
Oleovitamin D; Oleovitamin D2; Ostelin; Radiostol; Radsterin; Shock-Ferol;
Vitamin D2
Chemical Formula: C28H44O
Molecular Weight: 396.63
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDlow oral (dog)
4 mg/kg (*NIOSH/RTECS 1985)
TPQ: 1,000/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 239-244°F, 115-118°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 50-14-6
Page 2 of 4
ERGOCALCIFEROL
SECTION II (continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble in water (*Merck 1976)
Appearance and Odor: White crystals, odorless (*Osol 1975)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Ergocalciferol poisoning
disturbs calcium metabolism and causes kidney damage (Buchel 1983, p. 224).
Ergocalcif erol in a single acute ingestion presents no toxic hazards.
Daily ingestion in excess of 5000 units/day in children or 7500 units/day
in adults will produce toxic symptoms associated with hypervitaminosis D
(*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Those with
hypercalcemia are at a greater risk (Physicians' Desk Reference 1985, p.
1748)
SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Medicines, n.o.s.) Extinguish
with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984,
Guide 11).
Special Fire Fighting Procedures: (Non-Specific — Medicines, n.o.s.)
Move container from fire area if you can do so without risk. Spray cooling
water on containers that are exposed to flames until well after fire is out
(DOT 1984, Guide 11).
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 50-14-6
Page 3 of 4
ERGOCALCIFEROL
SECTION V -- REACTIVITY DATA
Stability: Unstable: Yes (*Furia 1972)
Stable:
Conditions to Avoid: Shows signs of decomposition when stored for a
few days at room temperature (*Furia 1972).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Nutrient and/or dietary supplement food additive (*Sax 1975).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Medicines, n.o.s.) Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas.
Shut off ignition sources; no flares, smoking or flames in hazard
area. Keep combustibles (wood, paper, oil, etc.) away from
spilled material. Do not touch spilled material. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 11).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Initial symptoms of ergocalciferol
poisoning include anorexia, nausea and vomiting. It often mimics
hyperparathyroidism with thirst, muscular weakness, nervousness, kidney
impairment, hypertension (*Gosselin 1976), and excessive urination (*Gilman
1980).
-------
CAS Registry Number: 50-14-6
Page 4 of 4
ERGOCALCIFEROL
SECTION IX (continued)
Emergency and First Aid Procedures: (Non-Specific — Medicines, n.o.s.)
Move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen. In
case of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Remove and isolate contaminated clothing
and shoes at the site. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 11).
-------
CAS Registry Number: 50-00-0
Page 3 of 5
FORMALDEHYDE
SECTION IV (continued)
UEL: 73% (*Sax 1975)
Extinguishing Methods: Small fires: dry chemical, carbon dioxide, water
spray or foam. Large fires: water spray, fog or foam. Move container
from fire area if you can do so without risk. Do not get water inside
container. Spray cooling water on containers exposed to flames until well
after fire is out. Withdraw immediately in case of rising sound from
venting safety device or any discoloration of tank due to fire (DOT 1984,
Guide 29).
Special Fire Fighting Procedures: Keep unnecessary people away; stay
upwind; keep out of low areas. Isolate for 1/2 mile in all directions if
tank car or truck is involved in fire (*DOT 1984). Wear self-contained
breathing apparatus; wear goggles if eye protection not provided. Shut off
flow of gas or liquid and keep cooling water streams on exposed tanks or
containers. Use water spray carefully in vicinity of dusts so as not to
create dust clouds (*NFPA 1978).
Unusual Fire and Explosion Hazards: Toxic vapors such as carbon dioxide
and carbon monoxide are generated during combustion (*Environment Canada
1982). Explosion hazard: when aqueous formaldehyde solutions are heated
above their flash points, a potential for explosion hazard exists. High
formaldehyde concentration or methanol content lowers flash point. Reacts
with nitrogen oxides at about 180; the reaction becomes explosive. Also
reacts violently with perchloric acid-aniline, performic acid,
nitromethane, magnesium carbonate, and hydrogen peroxide (Sax 1984, p.
1452).
NFPA Flammability Rating: 4 (gas); 2 (37% solution)
SECTION V -- REACTIVITY DATA
Stability: Unstable: Yes, aqueous solutions (*Lefaux 1968)
Stable: Yes, commercial formaldehyde-alcohol solutions
(*Kirk-Othmer 1978); gas is stable in absence of
water (*HeaIth and Safety Executive Monograph 1981)
Conditions to Avoid: Oxidizing and alkaline materials (*NFPA 1978)
Incompatibility (Materials to Avoid): Reacts with peroxide, nitrogen
oxide, and performic acid causing explosions (*Environment Canada 1982).
Can react with hydrogen chloride or other inorganic chlorides to form
bis-chloromethylether (BCME), a known carcinogen (*General Electric Co.
1981, MSDS 360). Very reactive, combines readily with many substances, 40%
solution is powerful reducing agent (*Merck 1976). Incompatible with
amines, azo compounds, dithiocarbamates, alkali and alkaline earth metals,
nitrides, nitro compounds, unsaturated aliphatics and sulfides, organic
peroxides, oxidizing agents, and reducing agents (*Environment Canada
1982).
Hazardous Decomposition or Byproducts: When heated, irritant formaldehyde
gas evolved from solution (Sax 1984, p. 1452). The main products of
-------
CAS Registry Number: 50-00-0
Page 4 of 5
FORMALDEHYDE
SECTION V (continued)
decomposition are carbon monoxide and hydrogen. Metals such as platinum,
copper, chromia, and alumina also catalyze the formation of methanol,
methylformate, formic acid, carbon dioxide, and methane (*Kirk- Othmer
1978).
Hazardous Polymerization: May Occur: Yes (*Environment Canada 1982)
May Not Occur:
Conditions to Avoid: Compound will polymerize with active organic
materials such as phenol (*General Electric Co. 1981, MSDS 360). Will
polymerize violently in the presence of caustics and nitrides; (amines)
exothermic reaction, (Azo compound) exothermic reaction giving off
nitrogen gas, (caustics) heat generation and violent polymerization,
(dithiocarbamates) formation of flammable gases and toxic fumes,
formation of carbon disulfide may result, (alkali and alkaline earth
metals) heat generation and formation of a flammable hydrogen gas
(*Environment Canada 1982).
SECTION VI - USE INFORMATION
Urea and melamine resins; polyacetal resins; phenolic resins; ethylene
glycol; pentaerythritol; hexamethylenetetramine; fertilizer; dyes, medicine
(disinfectant, germicide); embalming fluids; preservative; hardening agent;
reducing agent, as in recovery of gold and silver; corrosion inhibitor in
oil wells; durable-press treatment of textile fabrics; possible
condensation to sugars and other carbohydrates for food use (experimental);
industrial sterilant; treatment of grain smut (Hawley 1977, p. 395).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Shut off ignition sources; no flares, smoking or flames in hazard area. Do
not touch spilled material; stop leak if you can do so without risk. Use
water spray to reduce vapors; do not get water inside container. Small
spills: absorb with sand or other noncombustible absorbent material and
place into containers for later disposal. Large spills: dike far ahead of
spill for later disposal (DOT 1984, Guide 29). Use fluorocarbon water
spray, Cellosize, and Hycar to diminish vapors. Use sodium carbonate,
ammonium hydroxide or sodium sulfite to neutralize spill. Use universal
gel, fly/ash, universal sorbent material, or cement powder to absorb the
spill (*Environment Canada 1982).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 50-00-0
Page 1 of 5
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- FORMALDEHYDE
CAS Registry Number: 50-00-0
Synonyms: BFV; FA; Fannoform; Formaldehyde solution; Formaldehyde, as
Formalin solution (DOT); Formaldehyde, gas; Formalin; Formalin 40; Formalith;
Formic Aldehyde; Formol; Fyde; Hoch; Ivalon; Karsan; Lysoform; Methanal; Methyl
Aldehyde; Methylene Glycol; Methylene Oxide; Morbicid; NCI-C02799; Oxomethane;
Oxymethylene; Superlysoform
Chemical Formula: CH2O
Molecular Weight: 30.03
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 500 (pounds)
RQ: 1,000 (pounds) (statutory); 100 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Gas
Boiling Point: -3.1°F, -19.5°C at 760 mmHg (*Merck 1976); commercial
aqueous formaldehyde boils at 205°F, 96°C (Merck 1983, p. 604)
Specific Gravity (H2O=1): 1.067 (*Merck 1976); 0.815 at -20°C/4°C for
anhydrous form (Merck 1983, p. 604)
Vapor Pressure (mmHg): 10 at -88°C (*Patty 1963), for anhydrous form
Melting Point: -134°F,-92°C (*Merck 1976), for anhydrous form
Vapor Density (AIR=1): 1.03 for aqueous solution; 1.075 for gas
(*Environment Canada 1982), 1.067 for gas (Merck 1983, p. 604)
-------
CAS Registry Number: 50-00-0
Page 2 of 5
FORMALDEHYDE
SECTION II (continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble in water, up to 55% (*Merck 1976)
Appearance and Odor: Gas or liquid, strong, pungent odor, clear,
water-white (Sax 1984, p. 145).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: TWA 3 ppm; Ceiling Concentration 5 ppm; Peak Concentration 10
ppm/30 minutes/8 hours (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 1.5 mg/ms (1 ppm) (*ACGIH 1980); STEL 3 mg/ms (2 ppm)
(ACGIH 1986-87, p.19)
IDLH: 100 ppm (NIOSH/OSHA 1978, p. 104)
Other Limits Recommended: Occupational exposure to formaldehyde
recommended standard -- air ceiling concentration 1.2 mg/m3/30 minutes
(*NIOSH/RTECS 1985). Industrial substance suspect of carcinogenic
potential for humans recommended standard 1 ppm (ACGIH 1984, p. 42)
Routes of Entry: Inhalation: Yes (Proctor and Hughes 1978,
pp. 272-273)
Skin: Yes (Environment Canada 1982)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): The probable oral lethal
dose for humans is 0.5-5 g/kg, or between 1 ounce and 1 pint for a 150
pound person (*Gosselin 1976). Acute -- below 1 ppm, odor perceptible to
most. 2-3 ppm, mild tingling of eyes. 4-5 ppm, increased discomfort, mild
lacrimation. 10 ppm, profuse lacrimation; can be withstood only for few
minutes. 10-20 ppm, breathing difficult, cough, severe burning of nose and
throat. 50-100 ppm, acute irritation of respiratory tract, very serious
injury likely. Skin — primary irritation from strong solutions, gas.
Delayed — sensitization dermatitis (Proctor and Hughes 1978, pp. 272-273).
Suspected carcinogen (*Kirk-Othmer 1978). Effects in women include
menstrual disorders and secondary sterility (*IARC 1972-1985). Solutions
splashed in eyes have caused injuries ranging from severe, permanent
corneal opacification and loss of vision to minor discomfort (*Grant 1974).
Medical Conditions Generally Aggravated by Exposure: In people sensitized
to formaldehyde, late asthmatic reactions may be provoked by brief
exposures at approximately 3 ppm (*Hendrick 1982).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 60°C/40% solution (*Merck 1976)
Flammable Limits:
LEL: 7% (*Sax 1975)
-------
CAS Registry Number: Not Found
Page 3 of 3
ORGANORHODIUM COMPLEX
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Catalyst (PMN-82-147).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Poisonous Solid, n.o.s.) Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Do not touch spilled material; stop leak if you can do it
without risk. Small spills: take up with sand or other
non-combustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 53).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Poisonous Solid,
n.o.s.) Move victim to fresh air; call emergency medical care. Remove and
isolate contaminated clothing and shoes at the site. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes (DOT 1984, Guide 55).
-------
CAS Registry Number: Not Found
Premanufacture Notice Number: PMN-82-147
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- GENERIC NAME: ORGANORHODIUM COMPLEX
(This chemical was identified from a Premanufacture Review Notice (PMN)
submitted to EPA. The submitter has claimed certain information on the
submission to be confidential, including specific chemical identity,
chemical formula, and molecular weight.)
CAS Registry Number: Not Found
Synonyms: Not Found
Chemical Formula: Not Found
Molecular Weight: Not Found
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.08 mg/liter (submitter's estimate) (PMN-82-147)
TPQ: 10/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (PMN-82-147)
-------
CAS Registry Number: Not Found
Page 2 of 3
ORGANORHODIUM COMPLEX
SECTION II (continued)
Appearance and Odor: Green crystals (PMN-82-147)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: (Rhodium metal fume dust) 0.1 mg/ms, as rhodium (NIOSH 1987,
p. 204)
ACGIH TLV: (Insoluble Rhodium Compounds) TWA 1 mg/m3, as rhodium (A(
1984, p. 29)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): (Non-Specific —
Organometals) Organometals may be highly toxic orally. They are
irritating to skin, eyes, and mucous membranes. They can damage lung
tissue and the liver (Sax 1984, p. 2095).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Poisonous Solid, n.o.s.) Small
fires: dry chemical, carbon dioxide, water spray, or foam. Large fires:
water spray, fog or foam. Move container from fire area if you can do it
without risk (DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific « Poisonous Solid,
n.o.s.) Stay upwind; keep out of low areas. Wear self-contained (positive
pressure if available) breathing apparatus and full protective clothing
(DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: (Non-Specific -- Poisonous Solid,
n.o.s.) Fire may produce irritating or poisonous gases (DOT 1984, Guide
53).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 51-21-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- FLUOROURACIL
CAS Registry Number: 51-21-8
Synonyms: Uracil, 5-Fluoro-; 5-Fluorouracil; Efudex; Fluoroplex;
2,4-Dioxo-5-Fluoropyrimidine; 5-Fluoro-2,4( 1 H,3H)-Pyrimidinedione; 5-Fluoro-
2,4-Pyrimidinedione; 5-Fluoropyrimidine-2,4-Dione; 5-Fluoropyrimidine-
2,4-Dione; Fluoro Uracil; Fluracil; Fluril; FU; 5-FU; NSC 19893; RO 2-9757;
U-8953; 2,4(1 H,3H)-Pyrimidinedione, 5-Fluoro-
Chemical Formula: C4H3FN2O2
Molecular Weight: 130.08
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (rabbit)
18.9 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Decomposes at 540-541°F, 282-283°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g in 80 mL of water (*Osol 1975)
-------
CAS Registry Number: 51-21-8
Page 2 of 4
FLUOROURACIL
SECTION II (continued)
Appearance and Odor: White to practically white crystalline powder;
practically odorless (*Osol 1975)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Yes (Physicians' Desk Reference 1980, p. 1452)
Ingestion: Yes (*Goodman 1975)
Health Hazards (Acute, Delayed, and Chronic): Minimum toxic dose in
humans is approximately 450 mg/kg (total dose) over 30 days for the
ingested drug. Intravenous minimum toxic dose in humans is a total dose
of 6 mg/kg over three days. Depression of white blood cells occurred
after intravenous administrative of a total dose of 480 mg/kg over 32
days (*NIOSH/RTECS 1978).
Medical Conditions Generally Aggravated by Exposure: Occasional
neuropathy and cardiac toxicity have been reported (Oilman 1985, pp.
1270-1271). Do not use during pregnancy (Physicians' Desk Reference 1980,
p. 1455). Patients with impaired hepatic or renal function, with a
history of high-dose pelvic irradiation or previous use of alkylating
agents should be treated with extreme caution (Physicians' Desk Reference
1980, p. 1455). Patients with nutritional deficiencies and protein deple-
tion have a reduced tolerance to fluorouracil (Oilman 1985, p. 1270).
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Drugs or Medicines, n.o.s.
(Solid) Poison B) Extinguish fire using agent suitable for type of
surrounding fire (material itself burns with difficulty). Use water in
flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry
chemical (Student 1981, p. 215).
Special Fire Fighting Procedures: (Non-Specific ~ Drugs or Medicines,
n.o.s. (Solid) Poison B) Avoid breathing dusts, and fumes from burning
material. Keep upwind. Avoid bodily contact with the material. Wear
-------
CAS Registry Number: 51-21-8
Page 3 of 4
FLUOROURACIL
SECTION IV (continued)
boots, protective gloves, and goggles. Wear self-contained breathing
apparatus (Student 1981, p.-215).
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Osol 1975)
Conditions to Avoid: Decomposing heat (*Merck 1976)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Emits very toxic fumes of
flourides and nitrogen oxides when heated to decomposition (Sax 1984, p.
1450).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Antineoplastic drug (*Merck 1976); chemosterilant for insects
(*White-Stevens 1976).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Drugs) Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. If water
pollution occurs, notify appropriate authorities. Spill or leak:
shut off ignition sources; no flares, smoking or flames in hazard
area. Keep combustibles (wood, paper, oil etc.) away from spilled
material. Do not touch spilled material. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 11).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
-------
CAS Registry Number: 51-21-8
Page 4 of 4
FLUOROURACIL
SECTION VIII (continued)
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Loss of appetite and nausea are earliest
symptoms, with other symptoms of diarrhea, inflammation or sores in the
mouth, gastric burning, and intestinal discomfort. More serious symptoms
are due to the suppression of bone marrow, with decrease of white cell
count and blood platelets, and anemia. Hair loss, nail changes,
dermatitis, and pigmentation and atrophy of skin also occur (*Goodman
1975).
Emergency and First Aid Procedures: (Non-Specific -- Drugs) Move victim
to fresh air; call emergency medical care. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Remove and isolate contaminated clothing
and shoes at the site. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 11).
-------
CAS Registry Number: 51-75-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- MECHLORETHAMINE
CAS Registry Number: 51-75-2
Synonyms: 2,2'-Dichloro-N-Methyldiethylamine; 2-Chloro-N-(2-Chloroethyl)-
N-Methylethanamine; Beta,Beta'-Dichlorodiethyl-N-Methylamine; Bis(2-Chloro-
ethyl)Methylamine; Bis(Beta-Chloroethyl)Methylamine; Caryolysin; Chloramine
(the nitrogen mustard); Chlorethazine; Chlormethine; Di(2-Chloroethyl)
Methylamine; Dichlor Amine; Diethylamine, 2,2'-Dichloro-N-Methyl-; Embichin;
ENT-25294; Ethanamine, 2-Chloro-N-(2-Chloroethyl)-N-Methyl-; HN2; MBA;
Methylbis(2-Chloroethyl)Amine; Methylbis(Beta-Chloroethyl)Amine; Methylbis
(Chloroethylamine); Methyldi(2-Chloroethyl)Amine; Mustargen; Mustine;
N,N-Bis(2-Chloroethyl)methylamine; N,N-Di(Chloroethyl)Methylamine;
N-Methyl-2,2'-Dichlorodiethylamine; N-Methyl-bis(2-Chloroethyl)Amine;
N-Methyl-Bis(Beta-Chloroethyl)Amine; N-Methylbis(2-Chloroethyl)Amine;
N-Methylbis(Beta-Chloroethyl)Amine; Nitrogen Mustard; NSC 762; TL 146
Chemical Formula: C5HUC12N
Molecular Weight: 156.07
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 skin (rat)
14 mg/kg (*NIOSH/RTECS 1985)
TPQ: 10 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 189°F, 87°C at 18 mmHg (*Merck 1976)
Specific Gravity (H2O=1): 1.118 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: -76°F, -60°C (*Merck 1976)
-------
CAS Registry Number: 51-75-2
Page 2 of 4
MECHLORETHAMINE
SECTION II (continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very slightly soluble (*Merck 1976)
Appearance and Odor: Mobile liquid; faint odor of herring (*Merck 1976).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Gilman 1980)
Skin: Yes (*Gilman 1980)
Ingestion: Yes (*Gilman 1980)
Health Hazards (Acute, Delayed, and Chronic): Toxic doses as low as 400
mg/kg have been reported in humans (*NIOSH/RTECS 1985). Blood clots may
occur at site of intravenous injection and tissue damage if outside vein.
Powerful vesicant (causes blisters) when it contacts skin, mucous
membranes, or eyes. Delayed toxicity ~ missed menstrual periods, alopecia
(hair loss), hearing loss, tinnitus (ringing in ears), jaundice, impaired
spermatogenesis and germinal aplasia, swelling, and hypersensitivity
(*Gilman 1980).
Medical Conditions Generally Aggravated by Exposure: May damage fetus in
pregnant women (*Gilman 1980).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Poisonous Liquid, n.o.s.) Small
fires: dry chemical, carbon dioxide, water spray, or foam. Large fires:
water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific — Poisonous Liquid,
n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Move container from fire area if you can do
so without risk. Fight fire from maximum distance. Dike fire control
water for later disposal; do not scatter the material (DOT 1984, Guide 55).
-------
CAS Registry Number: 51-75-2
Page 3 of 4
MECHLORETHAMINE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Yes (*Merck 1976)
Stable:
Conditions to Avoid: Undiluted liquid decomposes on standing (*Merck
1976)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI « USE INFORMATION
Drug used in treatment of cancer (*Gilman 1980). Formerly used as a gas
warfare agent (*Merck 1976).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Poisonous Liquid, n.o.s.) Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Remove and isolate
contaminated clothing at the site. Do not touch spilled material; stop
leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible absorbent material
and place into containers for later disposal. Large spills: dike far
ahead of spill for later disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 51-75-2
Page 4 of 4
MECHLORETHAMINE
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
Chemical Resistance/Amount of Data)
Viton GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX ~ EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Nausea and vomiting; bleeding; skin
lesions; menstrual irregularities (*Gilman 1980).
Emergency and First Aid Procedures: Treat symptoms using procedures for
general poison (*Rumack 1975 to Present). (Non-Specific -- Poisonous
Liquid, n.o.s.) Move victim to fresh air; call emergency medical care. If
not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 51-83-2
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- CARBACHOL CHLORIDE
CAS Registry Number: 51-83-2
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 917) Choline, Chloride,
Carbamate; Carbachol; Carbacholin; Carbacholine; Carbacholine Chloride;
Carbacolina; Carbamic Acid, Ester with Choline Chloride; Carbaminocholine
Chloride; Carbaminoylcholine Chloride; Carbamiotin; Carbamoylcholine Chloride;
gamma-Carbamoyl Choline Chloride; Carbamoylcholine-Hydrochloride;
Carbamylcholine Chloride; Carbochol; Carbocholin; Carbocholine; Carbyl;
Carcholin; Choline Carbamate Chloride; Choline, Chloride Carbamate(Ester);
Choline Chloride, Carbamoyl-; Choline Chlorine Carbamate; Coletyl; Doryl; Doryl
(Pharmaceutical); Ethanaminium, 2-((Aminocarbonyl)oxy)-N,N,N-Trimethyl-,
Chloride; (2-Hydroxyethyl)Trimethyl Ammonium Chloride Carbamate; Isopto
Carbachol; Jestryl; Lentin; Miostat; Mistura C; Moryl; P.V. Carbachol; TL 457;
Vasoperif
Chemical Formula: C6H15N2O2C1
Molecular Weight: 182.68
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(mouse) 15 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 392-401°F, 200-205°C (Merck 1983, p. 245)
-------
CAS Registry Number: 51-83-2
Page 2 of 3
CARBACHOL CHLORIDE
SECTION II (continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g/mL (Merck 1983, p. 245)
Appearance and Odor: Crystalline, odorless, but on standing in an open
container, develops a faint odor resembling that of an aliphatic amine
(Merck 1983, p. 245); hygroscopic prisms or powder (Weast 1979, p. C-246)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Yes (Sax 1984, p. 631)
Ingestion: Yes (Sax 1984, p. 631)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic by mouth (Sax
1984, p. 631).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: The aqueous solution is stable even when heated
(Merck 1983, p. 245).
-------
CAS Registry Number: 51-83-2
Page 3 of 3
CARBACHOL CHLORIDE
SECTION V (continued)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits very toxic fumes of chloride and nitrogen oxides (Sax 1984, p. 631).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Cholinergic; parasympathomimetic, used chiefly in large animals, especially
for colic in the horse (Merck 1983, p. 245)
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid skin contact (see Section III above).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles foi additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Not Found
Emergency and First Aid Procedures: Not Found
COMMENTS
Sources searched but no information found:
DOT 1984
Farm Chemicals Handbook 1984
Oilman 1985
Hayes 1982
Gosselin 1984
Buchel 1983
Clayton and Clayton 1981-82
Hawley 1981
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CAS Registry Number: 54-11-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- NICOTINE
CAS Registry Number: 54-11-5
Synonyms: (-)-3-(l-Methyl-2-Pyrrolidyl)Pyridine; l-Methyl-2-(3-Pyridyl)
Pyrrolidine; beta-Pyridyl-alpha-N-Methylpyrrolidine; Destruxol Orchid Spray;
EMO-NIK; ENT 3,424; Flux Maag; Fumetobac; L-3-(l-Methyl-2-Pyrrolidyl)Pyridine;
L-Nicotine; Mach-Nic; Niagara PA Dust; Nic-Sal; Nico-Dust; Nico-Fume; Nicocide;
Nicotin; Nicotine Alkaloid; Ortho N-4 Dust; Ortho N-5 Dust; Pyridine,
3-(l-Methyl-2-Pyrrolidinyl)-, (S)-; Pyridine, 3-(Tetrahydro-
l-Methylpyrrol-2-yl); Pyrrolidine, l-Methyl-2-(3-Pyridyl)-; Tendust;
Tetrahydronicotyrine, DL-
Chemical Formula: C10H14N2
Molecular Weight: 162.23
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: Not Found
TPQ: 100 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 476.1°F, 246.7°C at 745 mmHg (*Weast 1979)
Specific Gravity (H2O=1): 1.0097 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 1 at 61.8°C (Sax 1984, p. 1997)
Melting Point: -110°F, -79°C (*Weast 1979)
Vapor Density (AIR=1): 5.61 (Sax 1984, p. 1997)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible below 60°C (*Merck 1983)
-------
CAS Registry Number: 54-11-5
Page 2 of 4
NICOTINE
SECTION II (continued)
Appearance and Odor: Colorless to pale yellow, oily liquid (*Merck 1983).
Slight, fishy odor when warm (NIOSH/OSHA 1978, pp. 138-139).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.5 mg/ms (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.5 mg/ms (skin) (*ACGIH 1983)
IDLH: 35 mg/ms (NIOSH/OSHA 1978, p. 138-139)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1997)
Skin: Yes (Merck 1983, p. 935)
Ingestion: Yes (Sax 1984, p. 1997)
Health Hazards (Acute, Delayed, and Chronic): It is classified as super
toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste
(less than 7 drops) for a 70 kg (150 Ibs.) person (*Gosselin 1976). It may
be assumed that ingestion of 40-60 mg of nicotine is lethal to humans.
There is fundamental difference between acute toxicity from use of nicotine
as insecticide or from ingestion, and chronic toxicity that may be caused
by prolonged exposure to small doses as occurs in smoking (*Encyc Occupat
Health and Safety 1983). Maternal smoking during pregnancy is associated
with increased risk of spontaneous abortion, low birth weight and
still-birth (*The Chemical Society 1975). Nicotine was found as a
co-carcinogen in animals (*NRC 1977).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Low fire hazard when exposed to heat or flame (Sax
1984, p. 1997)
LEL: 0.75% (Sax 1984, p. 1997)
UEL: 4.0% (Sax 1984, p. 1997)
Extinguishing Methods: Extinguish with alcohol foam, dry chemical, or
carbon dioxide (Sax 1984, p. 1997). Water may cause frothing if it gets
below surface of liquid and turns to steam. However, water fog gently
applied to surface will cause frothing which will extinguish the fire
(*NFPA 1978).
Special Fire Fighting Procedures: Material too dangerous to health to
expose firefighters. A few whiffs of the vapor could cause death; vapor or
liquid could be fatal on penetrating firefighter's normal full protective
clothing. Normal full protective clothing and breathing apparatus
available to the average fire department will not provide adequate
protection against inhalation or skin contact (*NFPA 1978).
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CAS Registry Number: 54-11-5
Page 3 of 4
NICOTINE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: There is a moderate explosion hazard
when exposed to heat or flame (.Sax 1984, p. 1997).
NFPA Flammability Rating: 1
SECTION V -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (normal conditions) (*NFPA 1978)
Conditions to Avoid: Heat or flames (*Sax 1975)
Incompatibility (Materials to Avoid): Avoid oxidizing materials (Sax
1984, p. 1997).
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits nitrogen oxides, carbon monoxide and other highly toxic fumes (Sax
1984, p. 1997).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
It is used as an insecticide, fumigant and in veterinary matters as an
ectoparasiticide and anthelmintic (*Merck 1983). Also, used in tanning
(*NRC 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
The normal full protective clothing and breathing apparatus available to
the average fire department will not provide adequate protection against
inhalation or skin contact with this material (*NFPA 1978). Do not touch
spilled material; stop leak; reduce vapors with water spray. Small Spills:
take up with sand or other noncombustible absorbent material and place
into containers for later disposal. Small Dry Spills: with clean shovel
place material into clean, dry container and cover; move containers from
spill area. Large Spills: dike far ahead of spill for later disposal (DOT
1984, Guide 55).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
-------
CAS Registry Number: 54-11-5
Page 4 of 4
NICOTINE
SECTION VIII (continued)
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 54-11-5
Page 1 of 3
Emergency First Aid Treatment Guide
for
NICOTINE
(54-11-5)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless to pale yellow oily liquid; brown on exposure to air.
Odor - Slightly fishy odor when warm.
Commercial Forms - 93 to 98% pure liquid; 3 to 5% dust.
Uses - Insecticide, fumigant, veterinary medicine, tanning.
Other Names - Black Leaf 40, Destruxol Orchid Spray; Futemobac; Nico-dust;
Nico-Fume; Ortho N-4 Dust; Ortho N-5 Dust; (S)-3-(l-methyl-2-pyrrolidinyl)
pyridine; Tendust.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal,
saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam,
phenytoin, phenobarbital, atropine.
Signs and Symptoms of Acute Nicotine Exposure:
Warning: Seizures may be rapid in onset. Caution is advised.
Acute exposure to nicotine may result in headache, dizziness, confusion,
agitation, restlessness, lethargy, seizures, and coma. Victims may experience
hypertension (high blood pressure), tachycardia (rapid heart rate), and
tachypnea (rapid respirations), followed by hypotension (low blood pressure),
bradycardia (slow heart rate), and respiratory depression. Cardiac arrhythmias
may also occur.
-------
EFATG
CAS Registry Number: 54-11-5
Page 2 of 3
NICOTINE
Gastrointestinal effects include nausea, vomiting, abdominal pain or burning
sensation, and diarrhea. Increased salivation, lacrimation (tearing), and
sweating may be noted.
Emergency Life-Support Procedures:
Acute exposure to nicotine may require decontamination and life support for the
victims. Emergency personnel should wear protective clothing appropriate to
the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to nicotine.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to nicotine.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. THOROUGHLY wash exposed skin areas with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
-------
EFATG
CAS Registry Number: 54-11-5
Page 3 of 3
NICOTINE
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. DO NOT induce vomiting or attempt to neutralize!
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
5. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
7. RUSH to a health care facility.
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CAS Registry Number: 54-62-6
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- AMINOPTERIN
CAS Registry Number: 54-62-6
Synonyms: (NIOSH/RTECS 1983, Synonyms, Volume 2, p. 375) Glutamic Acid,
N-(p-(((2,4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)-, L-;
4-Amino-4-Deoxypteroylglutamate; 4-Amino-PGA; Aminopteridine;
4-Aminopteroylglutamic Acid; A-Ninopterin; APGA; N-(4-((2,4-Diamino-6-
Pteridinyl)Methyl)Amino)Benzoyl)-L-Glutamic Acid; ENT-26079; Folic Acid,
4-Amino-; NSC 739; L-GIutamic Acid, N-[4-[(Diamino-6-Pteridinyl)Methyl]
Amino]Benzoyl]-
Chemical Formula: C19H2oN8O5
Molecular Weight: 440.47
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD,0 oral (rat)
2.5 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
-------
CAS Registry Number: 54-62-6
Page 2 of 3
AMINOPTERIN
SECTION II (continued)
Appearance and Odor: Clusters of yellow needles (Hawley 1981, p. 55)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Hawley 1981, p. 55)
Health Hazards (Acute, Delayed, and Chronic): An antimetabolite;
antagonizes the utilization of folic acid by the body. Highly toxic by
ingestion (Hawley 1981, p. 55).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
-------
CAS Registry Number: 54-62-6
Page 3 of 3
AMINOPTERIN
SECTION V (continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Rodenticide (Merck 1983, pp. 70-71); medicine and rodenticide (Hawley
1981, p. 55). Not registered as a rodenticide in the U.S. (USEPA/Active
Ingredients 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Pesticide, Solid, n.o.s.) Do not touch spilled material;
stop leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible absorbent material
and place into containers for later disposal. Small dry spills: with
clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) Move victim to fresh air; call emergency medical care. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush eyes with running water for at
least 15 minutes (DOT 1984, Guide 53).
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CAS Registry Number: 55-91-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ISOFLUORPHATE
CAS Registry Number: 55-91-4
Synonyms: Diisopropyl Fluorophosphate; DFP; Diflupyl; Diflurphate;
Diisopropoxyphosphoryl Fluoride; Diisopropyl Fluorophosphonate; Diisopropyl
Phosphofluoridate; Diisopropyl Phosphorofluoridate; Diisopropylfluoro-
phosphate; Diisopropylfluorophosphoric Acid Ester; Diisopropylphosphoro-
fluoridate; Dyflos; Dyphlos; Floropryl; Fluophosphoric Acid, Diisopropyl Ester;
Fluorodiisopropyl Phosphate; Fluostigmine; Fluropryl; Isofluro- phosphate;
Isopropyl Fluophosphate; Isopropyl Phosphorofluoridate; Neoglaucit;
O,O'-Diisopropyl Phosphoryl Fluoride; O,O,-Diisopropyl Fluorophosphate; PF-3;
Phosphorofluoridic Acid, Bis(l-Methylethyl) Ester; Phosphorofluoridic Acid,
Diisopropyl Ester; T-1703; TL 466; Fluorophosphoric Acid, Diisopropyl Ester;
Fluoropryl; Isofluorophate; Isoflurophate
Chemical Formula: C6H14FO3P
Molecular Weight: 184.15
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.36 mg/liter/10 minutes (*NIOSH/RTECS 1985)
TPQ: 100 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 144°F, 62°C at 9 mmHg (*Merck 1983)
Specific Gravity (H2O=1): 1.055 (*Merck 1983)
Vapor Pressure (mmHg): 0.579 at 20°C (*Merck 1983)
Melting Point: -116°F, -82°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 55-91-4
Page 2 of 4
ISOFLUORPHATE
SECTION II (continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1.54% by weight at 25°C (*Merck 1983)
Appearance and Odor: Oily liquid ("Hawley 1981). Clear, colorless or
faintly yellow liquid (*Osol 1980).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Merck 1983)
Skin: Yes (Sax 1984, p. 1667)
Ingestion: Yes (*Gosselin 1984)
Health Hazards (Acute, Delayed, and Chronic): This is an organophosphate
pesticide (*Morgan 1982). Extremely toxic: probable oral lethal dose in
humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for 70 kg person
(150 Ib.) (*Gosselin 1984). The material is a cholinesterase inactivator.
Even traces of the vapor cause pinpoint pupils (*Merck 1983).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
• ' UEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorous Pesticide,
n.o.s.) Dry chemical, carbon dioxide, water spray, or foam. For large
fires, water spray, fog, or foam. Fight fire from maximum distance. Dike
fire control water for later disposal (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Stay upwind; keep out of low areas.
Wear positive pressure breathing apparatus and special protective clothing
(DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: May burn but will not ignite readily.
Container may explode in heat of fire. Fire and runoff from fire control
water may produce irritating or poisonous gases (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 55-91-4
Page 3 of 4
ISOFLUORPHATE
SECTION V ~ REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Merck 1983)
Conditions to Avoid: Forms hydrofluoric acid in presence of moisture
(*Merck 1983). Keep away from sources of heat (*Farm Chemicals
Handbook 1984). Anhydrous compounds or oil solutions are stable in
glass containers at room temperature (*Merck 1983).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Forms hydrogen fluoride in
presence of moisture; decomposes in water at pH about 2.5 (*Merck 1983).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Research tool in neuroscience for its ability to inhibit cholinesterase (by
phosphorylation) on an acute/sub-acute basis and to produce a delayed
neuropathy (*Peer Review Committee). An insecticide. Used in Germany as a
basis for "nerve gases" (Sax 1984, p. 1667).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
When handling in open containers, protect the eyes, nose, and mouth with a
suitable mask, and avoid contact with skin (*Osol 1980).
(Non-Specific — Organophosphorus Pesticide, n.o.s.) Stay upwind; keep out
of low areas. Ventilate closed spaces before entering them. Remove and
isolate contaminated clothing at the site. Do not touch spilled material.
Use water spray to reduce vapors. Take up small spills with sand or other
noncombustible absorbent material and place in containers for later
disposal. Dike far ahead of large spills for later disposal (DOT 1984,
Guide 55).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 55-91-4
Page 4 of 4
ISOFLUORPHATE
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Respiration depression, muscle weakness,
twitching, and convulsions. Sweating, visual disturbances, vomiting,
diarrhea, chest and abdominal distress, and sometimes pulmonary edema
(*Morgan 1982).
Emergency and First Aid Procedures: Do not inhale vapors; avoid contact
with skin (*Merck 1983). (Non-Specific — Organophosphorous Pesticide,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal boc
temperature. Effects may be delayed; keep victim under observation (DO'
1984, Guide 55).
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CAS Registry Number: 56-25-7
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- CANTHARIDIN
CAS Registry Number: 56-25-7
Synonyms: 7-Oxabicyclo[2.2.1 ]Heptane-2,3-Dicarboxylic Anhydride,
2,3-Dimethyl-; l,2-Dimethyl-3,6-Epoxyperhydrophthalic Anhydride;
4,7-Epoxyisobenzofuran-l,3-Dione, Hexahydro-3a,7a-Dimethyl-, (3a alpha, 4 beta,
7 beta, 7a alpha)-; 2,3-Dimethyl-7-Oxabicyclo[2.2.1]Heptane-2,3- Dicarboxylic
Anhydride; CAN; Cantharides Camphor; Cantharidine; Cantharone;
Exo-l,2-cis-Dimethyl-3,6-Epoxyhexahydrophthalic Anhydride; Hexahydro-3a alpha,
7a alpha-Dimethyl-4 beta, 7 beta-Epoxyisobenzofuran-l,3-dione; Kantaridin
Chemical Formula: C10H12O4
Molecular Weight: 196.21
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDlo oral (hu-
man) 0.428 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Sublimes at 230°F, 110°C (Merck 1983, p. 242)
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 424°F, 218°C (*Weast 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble in cold water (*Merck 1976); somewhat
-------
CAS Registry Number: 56-25-7
Page 2 of 3
CANTHARIDIN
SECTION II (continued)
soluble in hot water (*Merck 1976).
Appearance and Odor: Brown to black powder (Sax 1984, p. 627);
orthorhombic plates, scales (Merck 1983, p. 242).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Sax 1979)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Arena 1979)
Health Hazards (Acute, Delayed, and Chronic): It is classified as super
toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste
of less than 7 drops for a 70 kg (150 Ib.) person (*Gosselin 1976). It is
very toxic by absorption through skin (*Merck 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 56-25-7
Page 3 of 3
CANTHARIDIN
SECTION V (continued)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits acrid smoke and irritating fumes (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Formerly used as a counter-irritant and vesicant (*IARC 1972-1985). Also
used for the removal of benign epithelial growth, e.g., warts (*Gilman
1980). Used as an experimental antitumor agent. Active ingredient in
Spanish fly, a reputed aphrodisiac (*Peer Review Committee).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section III above).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms from ingestion include vomiting,
abdominal pain, shock, bloody diarrhea, pain in throat and stomach,
swelling and blistering of tongue, difficulty swallowing, salivation, slow
and painful urination, and thirst. There may be delirium, fainting, and
tetanic convulsions (*Goodman 1975, *Rumack 1975 to Present, *Arena 1979,
*Gosselin 1976). Eye contact results in irritation with much swelling of
the lids (*Grant 1974). Initial tissue reaction upon contact with the skin
is swelling followed by blister formation within 24 hours (*Doull 1980).
Emergency and First Aid Procedures: For ingestion, induce vomiting with
syrup of ipecac. For skin contact thoroughly wash contaminated area with
soap and water. Eyes should be irrigated with plain tap water (*Rumack
1975 to Present).
-------
CAS Registry Number: 56-38-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PARATHION
CAS Registry Number: 56-38-2
Synonyms: Phosphorothioic Acid, O,O-DiethyI O-(p-Nitrophenyl) Ester (Liquid
Mixture); Parathion liquid; Alkron; Aileron; American Cyanamid 3422; Aphamite;
Bayer E-605; Bladan; Diethyl 4-Nitrophenyl Phosphorothionate; Diethyl
p-Nitrophenyl Thionophosphate; Diethyl Parathion; Diethyl-p-Nitrophenyl
Monothiophosphate; DNTP; E 605; ENT 15,108; Ethyl Parathion; Etilon; Folidol;
Fosferno; Fostox; Genithion; NA 2783 (DOT); NCI-C00226; Niran; Nitrostigmine;
O,O-Diethyl O-(p-Nitrophenyl) Phosphorothioate; O,O-Diethyl O-(p-nitrophenyl)
Thionophosphate; O,O-Diethyl O-4-Nitrophenyl Thiophosphate; O,O-Diethyl O-p-
Nitrophenyl Phosphorothioate; Oleoparathion; Panthion; Paraflow; Paramar;
Paraphos; Parawet; Phenphos; Phoskil; Phosphenol; Phosphorothioic Acid
O,O-Diethyl O-(4-Nitrophenyl) Ester; Rhodiatox; SNP; Stathion; Sulphos;
Thiophos; Vapophos
Chemical Formula: C10H14NO5PS
Molecular Weight: 291.27
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.084 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 100 (pounds)
RQ: 1 (pounds) (statutory); 10 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 707°F, 375°C (*Merck 1983)
Specific Gravity (H2O=1): 1.26 (*Merck 1983)
Vapor Pressure (mmHg): 0.0000378 at 20°C (*Worthing 1979)
Melting Point: 43°F, 6°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 56-38-2
Page 2 of 4
PARATHION
SECTION II (continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble; 12.4 mg/liter at 20°C
(*Bowman 1979)
Appearance and Odor: Pale yellow liquid; technical grade is brown and has
a garlic-like odor (*Worthing 1979).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: TWA 0.1 mg/m3 (NIOSH 1978, p. 148)
ACGIH TLV: TWA 0.1 mg/ms (skin) (ACGIH 1986-87, p.26)
IDLH: 20 mg/m3 (*Encyc of Occupat Health and Safety 1983)
Other Limits Recommended: NIOSH: 0.05 mg/m3, 10 hour TWA (NIOSH 1987,
p. 184)
Routes of Entry: Inhalation: Yes (*Gosselin 1976)
Skin: Yes (*Gosselin 1976)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is extremely
toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7 drops and
1 teaspoonful for a 150-lb. person. As little as 1 drop can endanger life
if splashed in the eye. Toxicity is highest by inhalation (*Gosselin
1976).
Medical Conditions Generally Aggravated by Exposure: People at special
risk are those with a history of glaucoma, cardiovascular disease, hepatic
disease, renal disease, or central nervous system abnormalities (*Encyc
Occupat Health and Safety 1983).
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 248-320°F, 120-160°C (Method not given)
(*Clayton and Clayton 1981-82)
Flammable Limits: Not highly flammable (*Encyc Occupat Health and Safety
1971)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use water spray, dry chemical, foam, or carbon
dioxide (*NFPA 1978).
Special Fire Fighting Procedures: Use water spray to keep fire-exposed
-------
CAS Registry Number: 56-38-2
Page 3 of 4
PARATHION
SECTION IV (continued)
containers cool. If a leak or spill has not ignited, use water spray to
disperse vapors and to provide protection for firefighters. Water spray
may be used to flush spills away from exposures. Fight advanced or massive
fires from a safe distance or from a protected location. Special
protective clothing should be worn; normal protective clothing may be
penetrated (*NFPA 1978).
Unusual Fire and Explosion Hazards: When heated to decomposition, it can
emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur. High
pressure hoses may scatter material from broken containers (*NFPA 1978).
Containers may explode when heated (*CHRIS 1978).
NFPA Flammability Rating: 1
SECTION V -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes, in distilled water and in acid solution
(*Hawley 1981)
Conditions to Avoid: Store below 25-30°C (*Farm Chemicals Handbook
1983). It slowly decomposes in air and hydrolyzes in the presence of
alkaline material (*Hawley 1981). Containers may explode when heated
(*CHRIS 1978).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, the
material can emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur
(*NFPA 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI « USE INFORMATION
This material is used as an insecticide (*SRI) and is used almost
exclusively in agriculture (Hayes 1982, p. 379).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of leaks or spills, special protective clothing should be worn.
Use water spray to disperse vapors and flush spills away (*NFPA 1978).
Ventilate area of spill or leak. Spills may be absorbed in vermiculite,
dry sand, earth, or a similar material (*NIOSH/OSHA 1981).
-------
CAS Registry Number: 56-38-2
Page 4 of 4
PARATHION
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 56-38-2
Page 1 of 3
Emergency First Aid Treatment Guide
for
PARATHION
(56-38-2)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Pale yellow or brown liquid.
Odor - Garliclike (commercial form).
Commercial Form - Deep brown liquid in tins and steel drums.
Use - Pesticide.
Materials to Avoid - Alkali, strong oxidizers.
Other Names - Alkron; Aileron; DNTP; ethyl parathion; Etilon; Folidol;
Fosferno; Fostex; Genithion; Niran; Nitrostigmine; Oleoparathion; Paraflow;
Paramar; Paraphos; Parawet; Phoskil; Phosphenol; phosphorothioic acid, O,O-
diethyl O-(p-nitrophenyl) ester; Rhodiatox; Stathion; Thiophos; Vapophos.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
atropine, pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Parathion Exposure:
Caution: Parathion is a cholinestorase inhibitor. It has been reported that
as little as one drop of parathion can endanger life if splashed in the eye.
Toxicity is highest by inhalation.
Acute exposure to parathion may produce the following signs and symptoms:
pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and
profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may
also occur.
-------
EFATG
CAS Registry Number: 56-38-2
Page 2 of 3
PARATHION
The heart rate may decrease following oral exposure or increase following
dermal exposure. Hypotension (low blood pressure) is not uncommon.
Respiratory symptoms include dyspnea (shortness of breath), respiratory
depression, and respiratory paralysis. Psychosis may occur.
Emergency Life-Support Procedures:
Acute exposure to parathion may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to parathion.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to parathion.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
-------
EFATG
CAS Registry Number: 56-38-2
Page 3 of 3
PARATHION
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of parathion is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of parathion may result in sudden onset of seizures or
loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
-------
CAS Registry Number: 56-72-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- COUMAPHOS
CAS Registry Number: 56-72-4
Synonyms: 3-Chloro-4-Methyl-7-Coumarinyl Diethyl Phosphorothioate;
3-Chloro-4-Methyl-7-Hydroxycoumarin Diethyl Thiophosphoric Acid Ester;
3-Chloro-4-Methylumbelliferone O-Ester with O,O-Diethyl Phosphorothioate;
3-Chloro-7-Hydroxy-4-Methyl-Coumarin O,O-Diethyl Phosphorothioate; 3-Chloro-
7-Hydroxy-4-Methyl-Coumarin O-Ester with O,O-Diethyl Phosphorothioate; Agridip;
Asunthol; Asuntol; Azunthol; Bay 21/199; Bayer 21/199; Baymix; Baymix 50;
Co-Ral; Coumafos; Coumarin, 3-Chloro-7-Hydroxy-4-Methyl-, O-Ester with
O,O-Diethyl Phosphorothioate; Diethyl 3-Chloro-4-Methylumbelliferyl
Thionophosphate; Diethyl Thiophosphoric Acid Ester of 3-Chloro-4-Methyl-
7-Hydroxycoumarin; Diolice; ENT 17,957; Meldane, Meldone, Muscatox, NCI-C08662;
O,O-Diethyl 3-Chloro-4-Methyl-7-Umbelliferone Thiophosphate; O,O-Diethyl
O-(3-Chloro-4-Methyl-2-Oxo-2H-Benzopyran-7-yl) Phosphorothioate; O,O-Diethyl
O-(3-Chloro-4-Methyl-7-Coumarinyl) Phosphorothioate; O,O-Diethyl
O-(3-Chloro-4-Methylcoumarinyl-7) Thiophosphate; O,O-Diethyl
O-(3-Chloro-4-Methylumbelliferone) Thiophosphate; O,O-Diethyl O-(3-Chloro-4-
Methylumbelliferyl) Phosphorothioate; O-3-Chloro-4-Methyl-7-Coumarinyl
O,O-Diethyl Phosphorothioate; Phosphorothioic Acid, O,O-Diethyl Ester, O-Ester
with 3-Chloro-7-Hydroxy-4-Methylcoumarin; Phosphorothioic Acid, O-(3-Chloro-
4-Methyl-2-Oxo-2H-l-Benzopyran-7-yl) O,O-Diethyl Ester; Resistox; Resitox;
Suntol; Umbethion
Chemical Formula: C14H16C1O5PS
Molecular Weight: 362.78
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.303 mg/liter (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
-------
CAS Registry Number: 56-72-4
Page 2 of 4
COUMAPHOS
SECTION II (continued)
Specific Gravity (H2O=1): 1.31 at 25°C (*Spencer 1973)
Vapor Pressure (mmHg): 0.0000001 at 20°C (*Spencer 1973)
Melting Point: 196°F; 91°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Merck 1983)
Appearance and Odor: Slightly brownish crystals (*Merck 1983). Slight
odor of sulfur compound (*CHRIS 1978)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Very toxic, probable oral
lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg
(150 Ib.) person (*Gosselin 1976). May be fatal if inhaled, swallowed, or
absorbed through skin. Contact may cause burns to skin and eyes (*DOT
1984).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE .AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This material may burn but does not ignite easily
(*DOT 1984). Extinguish with water, foam, carbon dioxide, or dry chemicals
(*CHRIS 1978)
Special Fire Fighting Procedures: Use organic vapor respirator, rubber
gloves, and goggles (*CHRIS 1978). Dike fire control water for disposal
later (*DOT 1984).
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CAS Registry Number: 56-72-4
Page 3 of 4
COUMAPHOS
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Toxic and irritating oxides of sulfur
and phosphorus may form in fire (*CHRIS 1978).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable:
Stable: Stable in water (*Merck 1983)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Incompatible with piperonyl
butoxide (*Farm Chemicals Handbook 1983)
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits very toxic fumes of sulfur oxides, phosphorus oxides, and chlorides
(Sax 1984, p. 726)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
For control of a wide variety of livestock insects including cattle grubs,
lice, scabies, flies, and ticks; the common ectoparasites of sheep, goats,
horse, swine, and poultry as well as for screwworms in all these animals
(Farm Chemicals Handbook 1983, p. C61).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do it without risk.
Use water spray to reduce vapors. Small spills: take up with sand or
other noncombustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel, place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (*DOT 1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 56-72-4
Page 4 of 4
COUMAPHOS
*
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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CAS Registry Number: 56-72-4
Page 1 of 3
Emergency First Aid Treatment Guide
for
COUMAPHOS
(56-72-4)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - White crystals.
Odor - Slightly sulfurous.
Commercial Forms - 1 and 5% pure dusts, 3% pure spray foam, 5 to 50% pure
slightly brownish crystals, 25% pure wettable powder.
Use - Veterinary insecticide.
Other Names - Agridip; Asuntol; 3-chloro-4-methyl-7-coumarinyl diethyl
phosphorothioate; Co-Ral; Coumafos; Meldane; Muscatox; Negasunt; Resistox;
Suntol; Umbethion.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
atropine, pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Coumaphos Exposure:
Note: Coumaphos is a cholinesterase inhibitor.
Acute exposure to coumaphos may produce the following signs and symptoms:
pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and
profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may
also occur. The heart rate may decrease following oral exposure or increase
following dermal exposure. Hypotension (low blood pressure) and chest pain may
be noted. Hypertension (high blood pressure) is not uncommon. Respiratory
effects include dyspnea (shortness of breath), respiratory depression, and
respiratory paralysis. Psychosis may occur.
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CAS Registry Number: 56-72-4
Page 2 of 3
COUMAPHOS
Emergency Life-Support Procedures:
Acute exposure to coumaphos may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to coumaphos.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to coumaphos.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least IS minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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CAS Registry Number: 56-72-4
Page 3 of 3
COUMAPHOS
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of coumaphos is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of coumaphos may result in sudden onset of seizures or
loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainly exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to
3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 57-14-7
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY ~ DIMETHYLHYDRAZINE
CAS Registry Number: 57-14-7
Synonyms: As-Dimethylhydrazine; Asym Dimethylhydrazine; Asymmetric
Dimethylhydrazine; Dimazin; Dimazine; 1,1-Dimethylhydrazine; Dimethylhydrazine
Unsymmetrical; DMH; Hydrazine, 1,1-Dimethyl; N,N-Dimethylhydrazine;
U-Dimethylhydrazine; UDMH; Uns-Dimethylhydrazine; Unsym-Dimethylhydrazine;
Unsymmetrical-Dimethylhydrazine
Chemical Formula: C2H8N2
Molecular Weight: 60.10
SECTION I ~ REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC60 inhalation
(mus) 0.422 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 1 (pounds) (statutory); 10 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 147°F, 63.9°C at 760 mmHg (*Merck 1983)
Specific Gravity (H2O=1): 0.7914 at 220C/4°C (*IARC 1972-1985)
Vapor Pressure (mmHg): 157 mmHg at 25°C (Sax, 1986, p.65)
Melting Point: -72°F, -58°C (*Merck 1983)
Vapor Density (AIR=1): 1.94 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble (*Encyc Occupat Health and Safety 1983)
Appearance and Odor: Clear, colorless liquid with characteristic
ammonia-like fish odor (*IARC 1972-1985). ;:
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CAS Registry Number: 57-14-7
Page 2 of 4
DIMETHYLHYDRAZINE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 1 mg/m8, (0.5 ppm) (NIOSH 1987, p.108)
ACGIH TLV: TWA 1 mg/ms, (0.5 ppm) (skin) (ACGIH 1986-87, p.17)
IDLH: 50 ppm (NIOSH/OSHA 1978, p. 88)
Other Limits Recommended: NIOSH: 0.15 mg/ms, 120 minute ceiling (NIOSH
1987, p.108). Industrial substance suspect of carcinogenic potential for
humans (ACGIH 1983, p. 43). SPEGL 0.24 ppm (60 minutes) (NRC 1985b, pp.
37-48).
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
.Health Hazards (Acute, Delayed, and Chronic): This compound exhibits high
acute toxicity as a result of exposure by all routes. Death or permanent
injury may result after very short exposure to small quantities (*Sax
1975). Chronic exposure may cause pneumonia, liver damage, and kidney
damage (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 5°F, -15°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: 2% (*Sax 1979)
UEL: 95% (*Sax 1979)
Extinguishing Methods: Use dry chemical, carbon dioxide, water spray, or
foam for small fires (*DOT 1984). In large fires water fog, carbon
dioxide, and bicarbonate agents may allow flashback and explosive
re-ignition (*CHRIS 1978).
Special Fire Fighting Procedures: Move containers from fire area if it
can be done without risk. Dike fire control water for later disposal, do
not scatter the material. Cool containers that are exposed to flames with
water until well after fire is out, wear positive pressure breathing
apparatus and special protective clothing. Isolate for one-half mile in
all directions if tank car or truck is involved in fire (*DOT 1984).
Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an
enclosed area (*CHRIS 1978). Vapors may travel to a source of ignition and
flashback. Runoff to sewer may create fire or explosion hazard (*DOT
1984).
NFPA Flammability Rating: 3
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CAS Registry Number: 57-14-7
Page 3 of 4
DIMETHYLHYDRAZINE
SECTION V ~ REACTIVITY DATA
Stability: Unstable:
Stable: Yes (NFPA .1984, p. 325M-43)
Conditions to Avoid: Dangerous when exposed to heat, flame, or
oxidizers (*Sax 1979).
Incompatibility (Materials to Avoid): Dissolves, swells, and
disintegrates many plastics (*CHRIS 1978).
Hazardous Decomposition or Byproducts: When it decomposes,
1,1-dimethylhydrazine gives off toxic nitrogen compound fumes (*Rumack 1975
to Present).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 364)
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Major uses include: chemical synthesis; stabilizer for organic peroxide
fuel additives; absorbent for acid gases; photography (*Hawley 1977); base
in rocket fuel formulations (*Merck 1983); stabilizer for plant growth
regulator (*Clayton and Clayton 1981-82).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Shut off ignition sources. Do not touch spilled material. Stop leak if
this can be done without risk. Use water spray to reduce vapors. Take up
small spills with sand or other non-combustible absorbent material and
place into containers for later disposal. Dike far ahead of large spills
for later disposal (*DOT 1984). Spills also may be removed with an
aspirator. Transfer to glass container and neutralize with dilute sulfuric
acid. Drain with copious amounts of water (*Rumack 1975 to Present).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
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CAS Registry Number: 57-14-7
Page 4 of 4
DIMETHYLHYDRAZINE
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl EXCELLENT/MANY
Butyl/Neoprene POOR/LIMITED*
CPE POOR/LIMITED
Chlorobutyl GOOD/LIMITED
Neoprene POOR/MANY
Nitrile POOR/MANY
PVC POOR/MANY
Teflon POOR/LIMITED
Viton POOR/LIMITED
Viton/Neoprene POOR/LIMITED*
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 57-14-7
Page 1 of 3
Emergency First Aid Treatment Guide
for
DIMETHYLHYDRAZINE
(57-14-7)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Clear, colorless liquid.
Odor - Ammonialike.
Commercial Form - 98% pure liquid in drums or tank cars.
Uses - Chemical synthesis, stabilizer for organic peroxide rocket fuel
formulations, acid gas absorbent, plant growth regulator, photography.
Materials to Avoid - Oxidizers.
Caution: Highly flammable. Avoid sources of extreme heat or ignition
including sparks or fire. Dimethylhydrazine will emit toxic nitrogen compounds
when heated to decomposition.
Other Names - Asym dimethylhydrazine, Dimazin, 1,1-dimethylhydrazine, UDMH.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
diazepam, phenytoin, phenobarbital, pyridoxine.
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CAS Registry Number: 57-14-7
Page 2 of 3
DIMETHYLHYDRAZINE
Signs and Symptoms of Acute Dimethylhydrazine Exposure:
Warning: Effects may be delayed for hours to days. Caution is advised.
Signs and symptoms of acute exposure to dimethylhydrazine may include eye
irritation, facial numbness, facial swelling, and increased salivation.
Headache, twitching, seizures, convulsions, and coma may also occur.
Gastrointestinal effects include anorexia, nausea, and vomiting. Pulmonary
edema and hypotension (low blood pressure) are common. Dimethylhydrazine is
toxic to the liver, ruptures red blood cells, and may cause kidney damage.
Dermal contact may result in strong skin and mucous membrane irritation.
Emergency Life-Support Procedures:
Acute exposure to dimethylhydrazine may require decontamination and life
support for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as dimethylhydrazine-resistant sheeting and
disposable bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to dimethylhydrazine.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to dimethylhydrazine.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
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CAS Registry Number: 57-14-7
Page 3 of 3
DIMETHYLHYDRAZINE
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of dimethylhydrazine is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of dimethylhydrazine may result in sudden onset of
seizures or loss of consciousness. Syrup of Ipecac should be
administered only if victims are alert, have an active gag-reflex, and
show no signs of impending seizure or coma. If ANY uncertainty exists,
proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 57-24-9
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - STRYCHNINE
CAS Registry Number: 57-24-9
Synonyms: Certox; Dolco Mouse Cereal; Kwik-Kil; Mole Death; Mouse-Nots;
Mouse-Rid; Mouse-Tox; Pied Piper Mouse Seed; Ro-Dex; Sanaseed; Strychnos;
Strychnidin-10-one; Strychnin
Chemical Formula: C21H22N2O2
Molecular Weight: 334.40
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD60 oral (mus)
2 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: 518°F, 270°C at SmmHg (*Merck 1983)
Specific Gravity (H2O=1): 1.36 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): Not Found
Melting Point: 514-554°F, 268-290°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g in 6400 ml (*Merck 1983).
Appearance and Odor: Colorless, transparent crystals or white crystalline
powder; odorless (*Osol 1980).
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CAS Registry Number: 57-24-9
Page 2 of 3
STRYCHNINE
*
SECTION III - HEALTH HAZARD DATA
OSHA PEL: 0.15 mg/ms (NIOSH 1987, p. 210)
ACGIH TLV: TWA 0.15 mg/ms (ACGIH 1986-87, p. 29)
IDLH: 3 mg/ms (NIOSH/OSHA 1978, p. 168)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Not Found
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Super toxic; probable oral
lethal dose in humans is less than 5 mg/kg, a taste (less than 7 drops) for
a 70 kg (150 Ib.) person. It causes violent generalized convulsions.
Death results from respiratory arrest as the respiratory muscles are in
sustained spasm (*Gosselin 1976). The lowest lethal oral dose reported for
humans is 30 mg/kg (*NIOSH/RTECS 1985).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Material may burn but does not ignite readily (*DOT
1984).
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish fire using agent suitable for type of
surrounding fire; material itself does not burn or burns with difficulty.
Use water in flooding quantities as fog. Use alcohol foam, carbon dioxide,
or dry chemical (Student 1981, p. 482).
Special Fire Fighting Procedures: Not Found >
Unusual Fire and Explosion Hazards: When heated, emits highly toxic fumes
(*Sax 1979). Fire may produce irritating or poisonous gases. Runoff from
fire control or dilution water may cause pollution (*DOT 1984).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Osol 1980)
Conditions to Avoid: Protect from light (*Merck 1983)
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CAS Registry Number: 57-24-9
Page 3 of 3
STRYCHNINE
SECTION V (continued)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Material (and its salts) is used for destroying rodents and predatory
animals and for trapping fur-bearing animals (*Merck 1983).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do so without risk.
Small spills: absorb with sand or other noncombustible absorbent material
and place into containers for later disposal. Small dry spills: with
clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 53). Avoid breathing dusts, and fumes from
burning materials. Keep upwind. Avoid bodily contact with the material.
Do not handle broken packages without protective equipment. Wash away
any material which may have contacted the body with copious amounts
of water or soap and water (Student 1981, p. 482).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 57-24-9
Page 1 of 3
Emergency First Aid Treatment Guide
for
STRYCHNINE
(57-24-9)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance. Characteristics:
Pure Forms - Colorless, transparent crystals or white crystalline powder.
Odor - None; bitter taste.
Commercial Form - Poisoned baits, usually as colored grain.
Uses - Rodenticide, sedatives, veterinary products.
Other Names - Certox, Kwik-Kil, Mouse-Rid, Mouse-Tox, Ro-Dex, Sanaseed,
Strychinos, strychnidin-10-one.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline
cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam,
phenytoin, phenobarbital, sodium bicarbonate, pancuronium bromide or curare,
succinylcholine.
Signs and Symptoms of Acute Strychnine Exposure:
Warning: Strychnine may induce convulsions within 15 to 60 minutes following
exposure. Caution is advised.
Respiratory paralysis and arrest are likely to occur following severe exposure
to strychnine. Signs and symptoms of acute exposure generally involve
excitation of all portions of the central nervous system. Convulsions,
bilateral horizontal nystagmus (rapid, synchronous, horizontal oscillations of
the eyeballs), agitation, restlessness, apprehension, and abrupt, jerking
movements of the extremities may occur.
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CAS Registry Number: 57-24-9
Page 2 of 3
STRYCHNINE
Victims may also experience stiffness, painful muscle cramping (especially in
the legs), and opisthotonos (spasm in which the spine and extremities are bent
with convexity forward, the body resting on the head and heels). Vomiting and
renal failure, as well as cyanosis (blue tint to skin and mucous membranes)
and rhabdomyolysis (destruction of skeletal muscle), may be found.
Emergency Life-Support Procedures:
Acute exposure to strychnine may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to strychnine.
Warning: Any unnecessary sensory input may induce seizures. Isolate the
victims from any avoidable distractions.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to strychnine.
Warning: Any unnecessary sensory input may induce seizures. Isolate the
victims from any avoidable distractions.
2. RUSH to a health care facility!.
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CAS Registry Number: 57-24-9
Page 3 of 3
STRYCHNINE
3. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
4. Remove contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least IS minutes.
6. Wash exposed skin areas THOROUGHLY with soap and water.
7. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
Warning: Any unnecessary sensory input may induce seizures. Isolate the
victims from any avoidable distractions.
2. RUSH to a health care facility!
3. DO NOT induce vomiting or attempt to neutralize.
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
5. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administereing a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
-------
CAS Registry Number: 57-47-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PHYSOSTIGMINE
CAS Registry Number: 57-47-6
Synonyms: Calabarine; Carbamic Acid, Methyl-, Ester with Eseroline; Erserine;
Eserine; Eserolein, Methylcarbamate (Ester); Esromiotin; Ezerin; Physostol;
Pyrrolo(2,3-b)indol-5-ol, l,2,3,3a,8,8a-Hexahydro-l,3a,8-Trimethyl-,
Methylcarbamate (Ester), (3aS-cis)-
Chemical Formula: C15H21NSO2
Molecular Weight: 275.34
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (mus)
4.5 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 221-223°F, 105-106°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (*Merck 1976)
Appearance and Odor: White, odorless, microcrystalline powder (*Osol
1980)
-------
CAS Registry Number: 57-47-6
Page 2 of 4
PHYSOSTIGMINE
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Gilman 1980)
Skin: Yes (*Gilman 1980)
Ingestion: Yes (*Gilman 1980)
Health Hazards (Acute, Delayed, and Chronic): Super toxic. Probable oral
lethal dose is less than 5 mg/kg for a 70 kg (150 Ib.) person (*Gosselin
1984). Material is a cholinesterase inhibitor. Effects of exposure may
involve the respiratory, gastrointestinal, cardiovascular and central
nervous systems. Death occurs due to respiratory paralysis or impaired
cardiac function. Time to death may vary from 5 minutes to 24 hours, in
severely poisoned patients, depending on factors such as the dose and route
(*Goodman 1980).
Medical Conditions Generally Aggravated by Exposure: Persons with asthma
and/or persons that require drugs containing choline esters are at risk
(*Osol 1975).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This is a carbamate pesticide (Hayes 1982, p.
436). As for carbamate pesticides, extinguish fire using agent suitable
for type of surrounding fire (material itself burns with difficulty). Use
water in flooding quantities as fog. Use alcohol foam, carbon dioxide or
dry chemical (Student 1981, p. 104).
Special Fire Fighting Procedures: This is a carbamate pesticide (Hayes
1982, p. 436). As for carbamate pesticides, wear self-contained breathing
apparatus when fighting fires (Student 1981, p. 104).
Unusual Fire and Explosion Hazards: It is a slight fire hazard (Sax 1984,
p. 2228).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
-------
CAS Registry Number: 57-47-6
Page 3 of 4
PHYSOSTIGMINE
SECTION V (continued)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Keep from light and heat (*Merck
1976).
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 2228).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Physostigmine is a carbamate pesticide (Hayes 1982, p. 436). Material is
used as a cholinergic (anticholinesterase) agent and as a veterinary
medication (*Merck 1976). Listed as a carbamate pesticide in Sections III
and VII, however, physostigmine is not registered in the U.S. as such
(USEPA/Pesticide Index 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
This is a carbamate pesticide (Hayes 1982, p. 436). As for other carbamate
pesticides, avoid breathing dusts, and fumes from burning materials. Keep
upwind. Avoid bodily contact with the material. Wash away any material
which may have contacted the body with copious amounts of water or soap and
water (*Student 1981).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: General symptoms include: increased
secretions, fatigability and generalized weakness, involuntary twitching,
severe weakness of skeletal muscles. Symptoms of exposure to material by
major organ system: gastrointestinal: lack of appetite, nausea and
vomiting, abdominal cramps and diarrhea. Central nervous system:
confusion, uncoordination, slurred speech, loss of reflexes, rapid,
irregular breathing, generalized convulsions, and coma. Cardiovascular:
slowed heart beat resulting in hypotension and fall in cardiac output
(*Goodman 1980). .-
-------
CAS Registry Number: 57-47-6
Page 4 of 4
PHYSOSTIGMINE
SECTION IX (continued)
Emergency and First Aid Procedures: Administer artificial respiration and
oxygen if needed (Sax 1984, p. 2228). If the victim's skin and hair are
contaminated, bathe with soap and water. If the material was ingested, the
stomach must be emptied (*Morgan 1976).
-------
CAS Registry Number: 57-57-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - PROPIOLACTONE, beta-
CAS Registry Number: 57-57-8
Synonyms: beta-Propiolactone; 2-Oxetanone; 3-Hydroxypropionic Acid Lactone;
3-Hydroxypropionic Acid, beta-Lactone; 3-Propanolide; 3-Propiolactone;
beta-Propionolactone; beta-Proprolactone; Betaprone; BPL; Hydracrylic Acid
Beta-Lactone; Hydracrylic Acid, beta Lactone; Propanoic Acid,
3-Hydroxy-,beta-Lactone; Propanolide; Propiolactone; Propionic Acid
3-Hydroxy-beta-Lactone; Propionic Acid, 3-Hydroxy-, beta-Lactone
Chemical Formula: CSH4O2
Molecular Weight: 72.06
SECTION I ~ REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.074 mg/liter (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 324°F, 162°C, decomposes (*Merck 1976)
Specific Gravity (H2O=1): 1.146 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 3.4 at 25°C (*IARC 1972-1985)
Melting Point: -27°F, -33°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 37% by volume (*Merck 1976)
-------
CAS Registry Number: 57-57-8
Page 2 of 4
PROPIOLACTONE, beta-
SECTION II (continued)
Appearance and Odor: A colorless liquid with a slightly sweetish, pungent
odor (*Encyc Occupat Health and Safety 1971; *IARC 1972-1985)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: TWA 1.5 mg/ms, (0.5 ppm); STEL 3 mg/ms,(l ppm) (ACGIH, 19i
30)
IDLH: Not Found
Other Limits Recommended: Industrial substance suspect of carcinogenic
potential for humans (ACGIH 1984, p. 41).
Routes of Entry: Inhalation: Yes (*Sax 1968)
Skin: Yes (Weiss 1980, p. 776)
Ingestion: Yes (*Sax 1968)
Health Hazards (Acute, Delayed, and Chronic): The toxicity potential of
this material via inhalation or ingestion is high; may cause death or
permanent injury after very short exposures to small quantities (*Sax
1968). It is a carcinogen (Weiss 1980, p. 776).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 70°C (158°F) (no method given) (*Merck 1976)
Flammable Limits:
LEL: 2.9% (*NFPA 1979)
UEL: Not Found
Extinguishing Methods: Alcohol foam (*Sax 1979). Extinguish with water,
dry chemical, foam, or carbon dioxide (Weiss 1980, p. 776).
Special Fire Fighting Procedures: Wear air mask, goggles or face shield,
rubber gloves, and protective clothing to prevent all skin contact. Cool
exposed containers with water (Weiss 1980, p. 776).
Unusual Fire and Explosion Hazards: Containers may explode (Weiss 1980,
p. 776). When heated to decomposition, it emits acrid smoke and fumes (Sax
1984, p. 2102).
NFPA Flammability Rating: 2
SECTION V - REACTIVITY DATA
Stability: Unftable:
Stable: Yes, stable when stored at 5°C (*Merck 1983)
-------
CAS Registry Number: 57-57-8
Page 3 of 4
PROPIOLACTONE, beta-
SECTION V (continued)
Conditions to Avoid: Avoid storing in areas of exposure to the direct
rays of the sun and in areas of high fire hazard (*Sax 1968). Tends to
polymerize on storage (*IARC 1972-1985).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits acrid smoke and fumes (Sax 1984, p. 2102).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Avoid elevated temperatures (Weiss 1980, p.
776).
SECTION VI -- USE INFORMATION
Intermediate in organic synthesis; disinfectant (*Merck 1976); sterilant
for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments
(*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid contact with liquid. Keep people away. Stop discharge (Weiss 1980,
p. 776). Avoid inhalation (see Section III above).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED
Neoprene POOR/LIMITED
Nitrile POOR/LIMITED
PE POOR/MANY
PVC POOR/LIMITED
Viton POOR/LIMITED
*Based on qualitative performance information.
**Based on a chemical analog.
-------
CAS Registry Number: 57-57-8
Page 4 of 4
PROPIOLACTONE, beta-
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Inhalation causes irritation of nose,
throat, and respiratory tract. Contact of liquid with eyes causes
irritation and tears. Contact with skin causes irritation and blistering;
fluid from blisters may cause additional blistering of adjacent skin.
Ingestion causes burns of mouth and stomach (Weiss 1980, p. 776).
Emergency and First Aid Procedures: Get medical attention following all
exposures to this compound. In case of inhalation, move victim to fresh
air; if breathing has stopped, give artificial respiration. If there has
been eye contact, flush eyes with water for at least 15 minutes. In case
of skin contact, flush with water (Weiss 1980, p. 776).
-------
CAS Registry Number: 57-64-7
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PHYSOSTIGMINE, SALICYLATE (1:1)
CAS Registry Number: 57-64-7
Synonyms: (SANSS 1983 Synonyms): Eserine Salicylate; Physostol Salicylate;
Salicylic Acid, compound with Physostigmine; Benzoic Acid, 2-Hydroxy-, compound
with (3aS-cis)-l,2,3,3a,8,8a-Hexahydro-l,3a,8-
Trimethylpyrrolo[2,3-b]indol-5-yl Methylcarbamate (1:1)
Chemical Formula: C15H21NSO2-C7H6O3
Molecular Weight: 413.52
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(mouse) 2.5 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 365-369°F, 185-187°C (Merck 1983, p. 1065)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 gram/75 mL at 25°C (Merck 1983, p. 1065)
Appearance and Odor: Crystal form that turns red on exposure to heat or
light (Merck 1983, p. 1065). ;
-------
CAS Registry Number: 57-64-7
Page 2 of 3
PHYSOSTIGMINE, SALICYLATE (1:1)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 2228)
Health Hazards (Acute, Delayed, and Chronic): This compound is similar to
physostigmine. It is classified as super toxic. The probable oral lethal
dose (humans) is less than 5 mg/kg or a taste for a 150 Ib. person. It is
a cholinesterase inhibitor (Gosselin 1984, p. 11-245).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 2228).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 57-64-7
Page 3 of 3
PHYSOSTIGMINE, SALICYLATE (1:1)
SECTION VI -- USE INFORMATION
Not Found
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Not Found
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: This compound is similar to physostigmine
(Gosselin 1984, p. H-245). Symptoms include nausea, vomiting, abdominal
cramps, diarrhea, excessive salivation, sweating, lassitude, weakness,
tightness in chest, vision disorders, tearing, ciliary muscle spasm, loss
of muscle coordination, slurring of speech, twitching of muscle, difficulty
in breathing, bluing of skin, convulsions, coma and death (Gosselin 1984,
p. 111-89).
Emergency and First Aid Procedures: This compound is similar to
physostigmine (Gosselin 1984, p. 11-245). Give oxygen and artificial
respiration as needed. Wash contaminated areas of the skin with soap and
water. Irrigate the eyes with water or saline. Keep patient under
constant observation for at least 24 hours (Gosselin 1984, p. 111-89).
COMMENTS
Sources with no information:
Doull 1980
Clayton and Clayton 1981-82
NFPA 1984
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CAS Registry Number: 57-74-9
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- CHLORDANE
CAS Registry Number: 57-74-9
Synonyms: l,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-Hexahydro-4,7-
Methanoindene; l,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-Hexahydro-4,7-Methylene
Indane; 4,7-Methano-lH-Indene, l,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-
Hexahydro-; 4,7-Methanoindan, 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-Tetrahydro-;
1068; Aspon-Chlordane; CD 68; Chlor Kil; Chlordane, Liquid (DOT); Chlorindan;
Corodan; Dowchlor; ENT 9,932; ENT-9932; HCS 3260; Kypchlor; M 140; M 410;
NCI-C00099; Niran; Octa-Klor; Octachloro-4,7-Methanohydroindane; Octachloro-
4,7-Methanotetrahydroindane; Octachlorodihydrodicyclopentadiene; Oktaterr;
Ortho-Klor; Synklor; TAT Chlor 4; Topiclor; Toxichlor; Velsicol 1068; Belt
Chemical Formula: C10H6C18
Molecular Weight: 409.80
SECTION I « REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC60 inhalation
(cat) 0.1 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 1 (pounds) (statutory); 1 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II » PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 347°F, 175°C at 2 mmHg ('Sunshine 1969)
Specific Gravity (H2O=1): 1.56-1.57 at 25°C/0°C (*Merck 1983)
Vapor Pressure (mmHg): 0.00001 at 25°C (*Sunshine 1969)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 57-74-9
Page 2 of 4
CHLORDANE
SECTION II (continued)
Solubility in Water: Insoluble (*Merck 1983)
Appearance and Odor: Amber viscous liquid with an aromatic, slightly
pungent odor (*Merck 1983, *CHRIS 1978)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Air: TWA 0.5 mg/ms (skin) (NIOSH 1987)
ACGIH TLV: 0.5 mg/m3 (ACGIH 1986-87)
IDLH: 500 mg/ms (*Clayton and Clayton 1981-82)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Gosselin 1984, pp. III-108-109)
Skin: Yes — More toxic to humans than by oral
administration (Gosselin 1984, pp. III-108-109)
Ingestion: Yes (Gosselin 1984, pp. III-108-109)
Health Hazards (Acute, Delayed, and Chronic): Fatal oral dose to adult
humans is between 6 and 60 g with onset of symptoms within 45 minutes to
several hours after ingestion, although symptoms have occurred following
very small doses either orally or by skin exposure. Some reports of
delayed development of liver disease, blood disorders and upset stomach.
Chlordane is considered to be borderline between a moderately and highly
toxic substance (Gosselin 1984, pp. III-108-109).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Flammable/combustible (*DOT 1984)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide, water
spray, and foam. Large fires: water spray, fog, or foam. Move containers
from fire area if it can be done without risk. Cool containers that are
exposed to flames with water from the side until well after fire is out
(*DOT 1984).
Special Fire Fighting Procedures: Isolate hazard area and deny entry.
Stay upwind. Wear positive pressure breathing apparatus and special
protective clothing. Isolate for 1/2-mile in all directions if tank car or
truck is involved in the fire (*DOT 1984).
Unusual Fire and Explosion Hazards: Flammable/combustible material; may
be ignited by heat, sparks or flames. Vapors may travel to a source of
ignition and flash back. Run-off to sewers may create fire or explosion
hazard. Containers may explode in heat of fire. Vapors are toxic indoors
-------
CAS Registry Number: 57-74-9
Page 3 of 4
CHLORDANE
SECTION IV (continued)
and outdoors (*DOT 1984).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Verschueren 1983, pp. 380-381)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Loses chlorine in presence of
alkaline reagents; should not be formulated with any solvent, carrier,
diluent or emulsifier which has alkaline reaction (*Merck 1983).
Hazardous Decomposition or Byproducts: Chlordane degrades under natural
environmental conditions to photoisomers, such as photo-cis- chlordane,
which are more toxic to certain animals than chlordane and also showed
higher bioaccumulation (*Khan et al. 1970).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
As of 1983, the only use in USA is for termite control (*IARC 1972-1985).
Previously used as agricultural home and garden pesticide or insecticide
(*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section III above). Shut off ignition sources.
Eliminate all smoking or flames in hazard area. Do not touch spilled
material. Use water spray to reduce vapors. Stay upwind. Small spills:
take up with sand or other noncombustible absorbent material, place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (*DOT 1984).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 57-74-9
Page 4 of 4
CHLORDANE
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Neoprene GOOD/LIMITED**
Nitrile POOR/LIMITED**
PVC POOR/LIMITED**
Viton GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Increased sensitivity to stimuli,
tremors, muscular incoordination, and convulsions with or without coma
(Gosselin 1984, pp. 111-108-109).
Emergency and First Aid Procedures: Move victim to fresh air and give
artificial respiration if indicated. Remove and isolate contaminated
clothing and shoes at site. If exposure to skin or eyes, flush with
running water for at least 15 minutes. Try to keep victim quiet. Effects
may be delayed so keep victim under observation (*DOT 1984).
-------
CAS Registry Number: 58-36-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PHENOXARSINE, 10,10'-OXYDI-
CAS Registry Number: 58-36-6
Synonyms: (SANSS 1983 Synonyms) lOH-Phenoxarsine, 10,10'-oxybis;
Bis(Phenoxarsin-10-yl)Ether; Bis(lO-Phenoxarsinyl) Oxide; Bis(lO-Phenoxarsyl)
Oxide; Estabex ABF; OBPA; SA 546; DID 47
Chemical Formula: C24H16As2O3 (Merck 1983, p. 998)
Molecular Weight: 502.23 (Merck 1983, p. 998)
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(guinea pig) 24 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): In Arsenic Compounds category
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 363-365°F, 184-185°C (Merck 1983, p. 998)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (5 ppm at 20°C) (Merck 1983,
p. 998)
Appearance and Odor: Colorless crystals (Merck 1983, p. 998)
-------
CAS Registry Number: 58-36-6
Page 2 of 4
PHENOXARSINE, 10,10'-OXYDI-
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: 0.010 mg/m3 (Arsenic and Compounds) (NIOSH 1984, p. 661)
ACGIH TLV: Air: TWA 0.2 mg (Arsenic)/m3 (ACGIH 1984, p. 10)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Non-Specific - Arsenic Compounds)
(Sax 1984, p. 320)
Skin: Yes (Non-Specific -- Arsenic Compounds)
(Sax 1984, p. 320)
Ingestion: Yes (Non-Specific -- Arsenic Compounds)
(Sax 1984, p. 320)
Health Hazards (Acute, Delayed, and Chronic): (Non-Specific -- Arsenic
Compounds) Arsenic compounds are acutely poisonous by ingestion.
Ingestion or inhalation may result in chronic poisoning. Arsenic compounds
are recognized carcinogens of the skin, lungs, and liver (Sax 1984, p.
320).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Arsenic Compound, Solid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large
fires: water spray, fog, or foam. Move container from fire area if you
can do so without risk (DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific ~ Arsenic Compound,
Solid, n.o.s.) Stay upwind; keep out of low areas. Wear self-contained
(positive pressure if available) breathing apparatus and full protective
clothing (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: (Non-Specific -- Arsenic Compounds)
When heated to decomposition, it emits highly toxic fumes of arsenic (Sax
1984, p. 320).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
-------
CAS Registry Number: 58-36-6
Page 3 of 4
PHENOXARSINE, 10,10'-OXYDI-
SECTION V (continued)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
This material is used primarily for fungicidal and bactericidal protection
of plastics (Merck 1983, p. 998).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Arsenic Compound, Solid, n.o.s.) Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Do not touch spilled material; stop leak if you can do so without
risk. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal.
Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: (Non-Specific -- Arsenic Compounds)
Ingestion causes nausea, vomiting, and diarrhea. In severe cases, there
may be bloody vomitus and stools and the victim may suffer collapse and
shock with weak, rapid pulse, cold sweats, coma, and death. Symptoms of
chronic poisoning may include loss of appetite, cramps, nausea,
constipation or diarrhea, jaundice, itching and pigmentation of the skin
(Sax 1984, p. 320).
-------
CAS Registry Number: 58-36-6
Page 4 of 4
PHENOXARSINE, 10,10'-OXYDI-
SECTION IX (continued)
Emergency and First Aid Procedures: (Non-Specific — Arsenic Compound,
Solid, n.o.s.) Move victim to fresh air; call emergency medical care.
Remove and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes (DOT 1984, Guide 53).
COMMENTS
Sources searched but no information found:
ACGIH 1983
NIOSH/OSHA 1978
Hawley 1981
Weast 1979
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Gosselin 1984
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Physicians' Desk Reference 1985
Oilman 1985
-------
CAS Registry Number: 58-89-9
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - LINDANE
CAS Registry Number: 58-89-9
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 1,000): Cyclohexane,
1,2,3,4,5,6-Hexachloro-, Gamma-Isomer; Aalindan; Aficide; Agrisol G-20;
Agrocide; Agrocide 2; Agrocide 7; Agrocide 6G; Agrocide III; Agrocide WP;
Agronexit; Ameisenatod; Ameisenmittel Merck; Aparasin; Aphtiria; Aplidal;
Arbitex; BBH; Ben-Hex; Bentox 10; Benzene Hexachloride-gamma-isomer;
gamma-Benzene Hexachloride; Bexol; BHC; gamma-BHC; Celanex; Chloresene;
Codechine; DBH; Detmol-Extrakt; Detox 25; Devoran; Dol Granule; Drill
Tox-Spezial Aglukon; Ent 7,796; Entomoxan; Exagama; Forlin; Gallogama; Gamacid;
Gamaphex; Gamene; Gammahexa; Gammahexane; Gammalin; Gammalin 20; Gammaterr;
Gammex; Gammexane; Gammopaz; Gexane; HCCH; HCH; gamma-HCH; Heclotox; Hexa;
Hexachloran; gamma-Hexachloran; Hexachlorane; gamma- Hexachlorane;
gamma-Hexachlorobenzene; l-alpha,2-alpha,3-beta,4-alpha,
5-alpha,6-beta-Hexachlorocyclohexane; gamma-Hexachlorocyclohexane; gamma-
1,2,3,4,5,6-Hexachlorocyclohexane; Hexachlorocyclohexane, gamma-Isomer;
1,2,3,4,5,6-Hexachlorocyclohexane, gamma-Isomer; Hexatox; Hexaverm; Hexicide;
Hexyclan; HGI; Hortex; Inexit; Isotox; Jacutin; Kokotine; Kwell; Lendine;
Lentox; Lidenal; Lindafor; Lindagam; Lindagrain; Lindagranox; gamma-Lindane;
Lindane (DOT); Lindapoudre; Lindatox; Lindosep; Lintox; Lorexane; Milbol 49;
Mszychol; NCI-C00204; NEO-Scabicidol; Nexen FB; Nexit; Nexit-Stark; Nexol-E;
Nicochloran; Novigam; Omnitox; Ovadziak; Owadzlak; Pedraczak; Pflanzol;
Quellada; Sang gamma; Silvanol; Spritz-Rapidin; Spruehpflanzol; Streunex; Tap
85; TRI-6; Viton
Chemical Formula: C6H6C16 (Weast 1979, p. C-262)
Molecular Weight: 290.83 (Weast 1979, p. C-262)
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (cat)
25 mg/kg (*NIOSH/RTECS 1985)
TPQ: 1,000/10,000 (pounds)
RQ: 1 (pounds) (statutory); 1 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
-------
CAS Registry Number: 58-89-9
Page 2 of 4
LINDANE
SECTION II (continued)
Boiling Point: 614°F, 323.4°C (Weast 1979, p. C-262); Decomposes
(NIOSH/OSHA 1978, p. 120)
Specific Gravity (H2O=1): 1.9 (DASE 1980, p. 529)
Vapor Pressure (mmHg): 0.0000094 at 20°C (Merck 1983, p. 789)
Melting Point: 234.5°F, 112.5°C (Weast 1979, p. C-262)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (Weast 1979, p. C-262)
Appearance and Odor: Colorless solid with a musty odor; pure material is
odorless (NIOSH/OSHA 1978, p. 120).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: 0.5 mg/m3 (NIOSH/OSHA 1978, p. 120)
ACGIH TLV: TWA 0.5 mg/m3 (ACGIH 1986)
IDLH: 1,000 mg/m3 (NIOSH/OSHA 1978, p. 120)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Gosselin 1984, p. III-240)
Skin: Yes (Gosselin 1984, p. III-240)
Ingestion: Yes (Gosselin 1984, p. IH-240)
Health Hazards (Acute, Delayed, and Chronic): Lindane is a stimulant of
the nervous system, causing violent convulsions that are rapid in onset and
generally followed by death or recovery within 24 hours (Hayes 1982, p.218).
The probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoon
and 1 ounce for a 150-lb (70 kg) person (Gosselin 1984, p. 11-286).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use dry chemical, carbon dioxide, water spray, or
foam for small fires. Use water spray, fog, or foam for large fires. Move
container from fire area if this can be done without risk. Use water to
-------
CAS Registry Number: 58-89-9
Page 3 of 4
LINDANE
SECTION IV (continued)
keep fire-exposed containers cool (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Isolate hazard area and deny entry.
Stay upwind and keep out of low areas. Ventilate closed spaces before
entering. Wear positive pressure breathing apparatus and special
protective clothing. Fight fire from maximum distance, dike fire control
water for later disposal (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, this
compound emits toxic fumes of chlorine, hydrochloric acid, and phosgene
(Sax 1984, p. 366).
NFPA Flammability Rating: 1 (solution); 0 (dry)
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Thermal decomposition products may
include chlorine, hydrochloric acid, and phosgene (Sax 1984, p. 366).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Pesticide (Hawley 1981, p. 617) and scabicide (Hayes 1982, p. 221).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material. Sweep or shovel material into a clean, dry
container. Carefully collect remainder (DASE 1980, p. 529; DOT 1984,
Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 58-89-9
Page 4 of 4
LINDANE
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/LIMITED**
Butyl/Neoprene POOR/LIMITED**
CPE POOR/LIMITED**
Neoprene POOR/LIMITED**
Nitrile POOR/LIMITED**
PE POOR/LIMITED**
PVC POOR/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Contact with eyes or skin may produce
irritation (DASE 1980, p. 529). Vomiting, faintness, tremor, restlessness,
muscle spasms, unsteady gait, and convulsions may occur as a result of
exposure. Elevated body temperature and pulmonary edema have been reported
in children. Coma, respiratory failure and death can result. Exposure to
vapors of this compound or its thermal decomposition products may lead to
headache, nausea, vomiting, and irritation of the eyes, nose, and throat
(Gosselin 1984, pp. IH-240, 241).
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes,
speed in removing material from the skin is of extreme importance. Remove
and isolate contaminated clothing and shoes at the site. Keep victim quiet
and maintain normal body temperature. Effect may be delayed; keep victim
under observation (DOT 1984, Guide 55).
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CAS Registry Number: 59-88-1
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PHENYLHYDRAZINE HYDROCHLORIDE
CAS Registry Number: 59-88-1
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 457): Hydrazine, Phenyl-,
Hydrochloride; Hydrazine, Phenyl-, Monohydrochloride; Phenylhydrazine
Monohydrochloride; Phenylhydrazinium Chloride
Chemical Formula: C6H8N2-HC1
Molecular Weight: 144.62
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDlow oral
(rabbit) 25 mg/kg (*NIOSH/RTECS 1985).
TPQ: 1,000/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not pertinent; it decomposes (Weiss 1980, p. 744)
Specific Gravity (H2O=1): Greater than 1 at 20°C (Weiss 1980, p. 744)
Vapor Pressure (mmHg): Not Found
Melting Point: 469-475°F, 243-246°C (Merck 1983, p. 1051)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Freely soluble (Merck 1983, p. 1051)
Appearance and Odor: White to tan solid; weak aromatic odor (Weiss 1980,
p. 744).
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CAS Registry Number: 59-88-1
Page 2 of 3
PHENYLHYDRAZINE HYDROCHLORIDE
r
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Occupational exposure to hydrazines recommended
standard: ceiling 0.6 mg/ms/2 hours (Air) (Sax 1984, p. 2190).
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 744)
Skin: Yes (Weiss 1980, p. 744)
Ingestion: Yes (Weiss 1980, p. 744)
Health Hazards (Acute, Delayed, and Chronic): This material is poisonous
if swallowed or if fumes are inhaled. Dust is irritating to eyes, nose,
and throat. Phenylhydrazine is a chronic poison (Weiss 1980, p. 744).
Phenylhydrazine is an industrial substance suspect of carcinogenic
potential for humans (ACGIH 1983, p. 43).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV « FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Combustible (Weiss 1980, p. 744)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use water, foam, dry chemical, or carbon dioxide
(Weiss 1980, p. 744).
Special Fire Fighting Procedures: Wear goggles and self-contained
breathing apparatus (Weiss 1980, p. 744).
Unusual Fire and Explosion Hazards: Toxic and irritating hydrogen
chloride and oxides of nitrogen may be produced in fire (Weiss 1980, p.
744).
NFPA Flammabiiity Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 744)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): May be corrosive to metals (Weiss
1980, p. 744).
-------
CAS Registry Number: 59-88-1
Page 3 of 3
PHENYLHYDRAZINE HYDROCHLORIDE
SECTION V (continued)
Hazardous Decomposition or Byproducts: Hydrogen chloride and oxides of
nitrogen (Weiss 1980, p. 744).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 744)
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Hemolytic (Merck 1983, p. 1051).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid contact with solid and dust. Restrict access. Disperse and flush
(Weiss 1980, p. 744). (Non-Specific -- Phenylhy^drazine) Keep
unnecessary people away; isolate hazard area a*nd deny entry. Stay
upwind; keep out of low areas. Do not touch spilled material; stop leak if
you can do it without risk. Small spills: take up with sand or other
noncombustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 53).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Ingestion or inhalation of fumes can
cause nausea, jaundice, anorexia, and blood clots. It may also cause
anemia and liver injury. Contact with eyes causes irritation. Contact
with skin causes irritation and dermatitis. Inhalation of dust can cause
coughing and difficult breathing (Weiss 1980, p. 744).
Emergency and First Aid Procedures: Move victim to fresh air. Remove
contaminated clothing and shoes. For ingestion, give a large amount of
water; induce vomiting. If eyes are exposed, flush with water for at least
15 minutes. If skin is exposed, flush with water (Weiss 1980, p. 744).
-------
CAS Registry Number: 60-34-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - METHYL HYDRAZINE
CAS Registry Number: 60-34-4
Synonyms: 1-Methylhydrazine; Hydrazine, Methyl-; Hydrazomethane; MMH;
Monomethylhydrazine; UN 1244
Chemical Formula: CH6N2
Molecular Weight: 46.07
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(mouse) 0.105 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 190°F, 87.5°C (*Merck 1983)
Specific Gravity (H2O=1): 0.874 at 25°C (*Merck 1983)
Vapor Pressure (mmHg): 49.6 at 25°C (*Sunshine 1969)
Melting Point: -62.3°F, -52.4°C (*Merck 1983)
Vapor Density (AIR=1): 1.6 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible with water (*Merck 1983)
Appearance and Odor: It is a colorless liquid (*Sax 1979) with an odor
characteristic of short-chain, organic amines, or ammonia-like (*Merck
1983, *Clayton and Clayton 1981-82).
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CAS Registry Number: 60-34-4
Page 2 of 4
METHYL HYDRAZINE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Ceiling 0.35 mg/m3 (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: Ceiling 0.35 mg/m3 (skin) (*ACGIH 1983)
IDLH: 5 ppm (*Encyc Occupat Safety and Health 1983)
Other Limits Recommended: Methyl hydrazine is a suspected human carcinogen
with a NIOSH recommended ceiling concentration of 0.08 mg/m3/2 hour (*ACGIH
1984 and *NIOSH 1985). SPEGL 0.24 ppm (60 minutes) (NRC 1985b, pp. 23-36).
Routes of Entry: Inhalation: Yes (*Clayton and Clayton 1981-82)
Skin: Yes (*Clayton and Clayton 1981-82)
Ingestion: Yes (*Clayton and Clayton 1981-82)
Health Hazards (Acute, Delayed, and Chronic): Methyl hydrazine vapors are
extremely toxic and the liquid is corrosive to skin. Methyl hydrazine is
the strongest convulsant and the most toxic of methyl-substituted hydrazine
derivatives (*Clayton and Clayton 1981-82). It is more toxic than
hydrazine (*NFPA 1978). At high doses, it is a strong central nervous
system poison that can lead to convulsions and death (*Encyc Occupat Health
and Safety 1971)
Medical Conditions Generally Aggravated by Exposure: Skin rash may be
aggravated by skin exposure (*Encyc Occupat Health and Safety 1971).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 70°C (OC) (*Merck 1983)
Flammable Limits:
LEL: 2.5% (Sax 1984, p. 1858)
UEL: 97% (Sax 1984, p. 1858)
Extinguishing Methods: For small fires, use dry chemical, carbon dioxide,
water spray, and foam. For large fires, use water spray, fog, or foam.
Keep unnecessary people away and isolate the hazardous area. Stay upwind
and keep out of low-lying areas (DOT 1984, Guide 28). Fire exposed
containers should be kept cool with water. Use water spray to disperse
vapors and protect men attempting to stop a leak which has not ignited
(*NFPA 1978). Move container from fire area if it can be done without risk
(*DOT 1984).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special (full) protective clothing. No skin surface should
be exposed (*NFPA 1978). Isolate area for 1/2-mile in all directions if a
tank car or truck is involved in a fire (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: Extremely flammable; ignites
spontaneously under almost all normal temperature conditions (*NFPA 1978).
Water used to extinguish a fire may cause pollution and should be diked for
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CAS Registry Number: 60-34-4
Page 3 of 4
METHYL HYDRAZINE
SECTION IV (continued)
later disposal (DOT 1984, Guide 28). Water may be ineffective in
extinguishing fires due to the chemical's low flash point. Because of the
wide flammability limits, low flash point, and reignition hazard, dry
chemicals, carbon dioxide, water spray, and foam may not be as effective as
water dilution of fire area. The vapor is heavier than air; thus it may
accumulate sufficiently to flash back (*NFPA 1978).
NFPA Flammability Rating: 3
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Heat or flame should be avoided because
chemical is extremely flammable and explosive (*Sax 1979).
Incompatibility (Materials to Avoid): Ignites spontaneously in air when
in contact with porous materials (e.g., earth, asbestos, wood, or cloth)
(*NFPA 1978). Also ignites spontaneously on contact with strong oxidizing
agents (e.g., fluorine, chlorine trifluoride, fuming nitric acid, and
nitrogen tetroxide) (*Merck 1983).
Hazardous Decomposition or Byproducts: Methylhydrazine fires produce
irritating nitrogen oxides (*NFPA 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI ~ USE INFORMATION
Used as a chemical intermediate and solvent (*ACGIH 1980). Also used as a
component of rocket propellants (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In the case of a spill or leak, shut off ignition sources, and extinguish
or disallow flares, smoking, or flames in the hazard area. Do not touch
the spilled material, and stop leak if it can be done without risk. Use
water spray to reduce vapors. For small spills, take up the chemical with
sand or other noncombustible absorbent material and place it in containers
for later disposal. For large spills, dike far ahead for later disposal
(*DOT 1984).
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CAS Registry Number: 60-34-4
Page 4 of 4
METHYL HYDRAZINE
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/MANY
CPE POOR/LIMITED
Chlorobutyl GOOD/LIMITED
PVC POOR/LIMITED
Teflon POOR/MANY
Viton GOOD/LIMITED
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 60-34-4
Page 1 of 3
Emergency First Aid Treatment Guide
for
METHYL HYDRAZINE
(60-34-4)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Colorless liquid.
Odor - Ammonialike.
Uses - Chemical intermediate, solvent, rocket propellant.
Materials to Avoid - Porous materials, acids, oxidizers.
Caution: Extremely flammable. Avoid sources of extreme heat or ignition
including sparks or fire. Methyl hydrazine may spontaneously self-ignite.
Other Names - Hydrazomethane, 1-methylhydrazine, MMH, monomethylhydrazine,
UN 1244.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal,
saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam,
phenytoin, phenobarbital, pyridoxine.
Signs and Symptoms of Acute Methyl Hydrazine Exposure:
Warning: Symptoms may be delayed from hours to days. Caution is advised.
Symptoms of acute exposure to methyl hydrazine may include facial numbness,
facial swelling, and increased salivation. Headache, twitching, seizure,
convulsions, and coma may also occur. Gastrointestinal signs and symptoms
include anorexia, nausea, and vomiting. Pulmonary edema and hypotension (low
blood pressure) are common.
-------
EFATG
CAS Registry Number: 60-34-4
Page 2 of 3
METHYL HYDRAZINE
Methyl hydrazine is toxic to the liver, ruptures red blood cells, and may
cause kidney damage. Contact with the skin, eyes, or mucous membranes may
result in severe irritation and permanent damage.
Emergency Life-Support Procedures:
Acute exposure to methyl hydrazine may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to methyl hydrazine.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to methyl hydrazine.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
-------
EFATG
CAS Registry Number: 60-34-4
Page 3 of 3
METHYL HYDRAZINE
Ingestion Exposure:
1. Evaluate vital signs including .pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. RUSH to a health care facility.
-------
CAS Registry Number: 60-41-3
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- STRYCHNINE, SULFATE
CAS Registry Number: 60-41-3
Synonyms: (NIOSH/RTECS Synonyms 1983, Volume 3, p. 650) Strychnine, Sulfate
(2:1); Strychnine Sulfate; Strychnidin-10-one, Sulfate (2:1)
Chemical Formula: C21H22N2O2- 1/2 H2O4S
Molecular Weight: 383.49
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (rat)
5 mg/kg (*NIOSH/RTECS 1985).
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 392°F, 200°C with decomposition (Merck 1983, p. 1269)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g dissolves in 35 mL, 7 mL boiling water (Merck
1983, p. 1269)
Appearance and Odor: Colorless, odorless, very bitter crystals; white
crystalline powder (Merck 1983, p. 1269).
-------
CAS Registry Number: 60-41-3
Page 2 of 3
STRYCHNINE, SULFATE
•
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 1156)
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 2473)
Health Hazards (Acute, Delayed, and Chronic): Violent poison! (Merck
1983, p. 1269). Lowest published lethal dose orally in humans is 30 mg/kg
(Weiss 1980, p. 1156).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Strychnine and Salts) Small
fires: dry chemical, carbon dioxide, water spray, or foam. Large fires:
water spray, fog, or foam. Move container from fire area if you can do it
without risk (DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Strychnine and Salts)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing (DOT 1984,
Guide 53).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of sulfur oxides and nitrogen oxides (Sax 1984, p.
2473).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Protect from light (Merck 1983, p. 1269).
Incompatibility (Materials to Avoid): Alkalies, alkali carbonates and
-------
CAS Registry Number: 60-41-3
Page 3 of 3
STRYCHNINE, SULFATE
SECTION V (continued)
bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric
acids, salicylates, borax, gold chloride and other alkaloid precipitants,
piperazine, potassium-mercuric iodide (Merck 1983, p. 1269).
Hazardous Decomposition or Byproducts: Emits very toxic fumes of sulfur
oxides and nitrogen oxides when heated to decomposition (Sax 1984, p.
2473).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Has been used as a tonic and stimulant in veterinary medicine (Merck 1983,
p. 1269). Registered as a rodenticide in the U.S. (USEPA/Pesticide Index
1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Strychnine and Salts) Do not touch spilled material;
stop leak if you can do it without risk. Small spills: take up with sand
or other noncombustible absorbent material and place into containers
for later disposal. Small dry spills: with clean shovel place material
into clean, dry container and cover; move containers from spill area.
Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 53).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 60-41-3
Page 1 of 3
Emergency First Aid Treatment Guide
for
STRYCHNINE SULFATE
(60-41-3)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Colorless crystals or white, crystalline powder.
Odor - None; bitter taste.
Uses - Rodenticide, tonic and stimulant in veterinary medicine.
Other Names - Kilmice; Mole-Nots; Mouse-Nots; strychnidin-10-one, sulfate.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal,
saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam,
phenytoin, phenobarbital, sodium bicarbonate, pancuronium bromide or curare,
succinylcholine.
Signs and Symptoms of Acute Strychnine Sulfate Exposure:
Warning: Strychnine sulfate may induce convulsions within 15 to 60 minutes
following exposure. Caution is advised. Vital signs should be monitored
closely.
Signs and symptoms of acute exposure to strychnine sulfate generally involve
excitation of all portions of the central nervous system. Convulsions,
bilateral horizontal nystagmus (rapid, synchronous, horizontal oscillations of
the eyeballs), agitation, restlessness, apprehension, and abrupt, jerking
movements of the extremities may occur.
-------
EFATG
CAS Registry Number: 60-41-3
Page 2 of 3
STRYCHNINE SULFATE
Victims may also experience stiffness, painful muscle cramping (especially in
the legs), opisthotonos (spasm in which the spine and extremities are bent
with convexity forward, the body resting on the head and heels), and vomiting.
Respiratory paralysis and arrest are likely to occur following severe exposure
to strychnine sulfate. Cyanosis (blue tint to skin and mucous membranes),
rhabdomyolysis (destruction of skeletal muscle), and renal failure may also be
found.
Emergency Life-Support Procedures:
Acute exposure to strychnine sulfate may require decontamination and life
support for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to strychnine sulfate.
Warning: Any unnecessary sensory input may induce seizures. Isolate the
victims from any avoidable distractions.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to strychnine sulfate.
Warning: Any unnecessary sensory input may induce seizures. Isolate the
victims from any avoidable distractions.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
-------
EFATG
CAS Registry Number: 60-41-3
Page 3 of 3
STRYCHNINE SULFATE
4. Remove contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
6. THOROUGHLY wash exposed skin areas with soap and water.
7. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
Warning: Any unnecessary sensory input may induce seizures. Isolate the
victims from any avoidable distractions.
2. RUSH to a health care facility!
3. DO NOT induce vomiting or attempt to neutralize.
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
5. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
-------
CAS Registry Number: 60-51-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- DIMETHOATE
CAS Registry Number: 60-51-5
Synonyms: 8014 Bis HC; Acetic Acid, O,O-DimethyldithiophosphoryI-, N-Mono-
methylamide Salt; American Cyanamid 12,880; BI 58; CL 12880; Cygon; Cygon 4E;
Cygon Insecticide; Daphene; De-Fend; Demos-L40; Dimethogen; Dimeton; Dimevur;
ENT 24650; Experimental Insecticide 12,880; FIP; Fosfotox; Fosfotox R; Fosfotox
R 35; Fostion MM; Lurgo; NCI-COO 135; O,O-Dimethyl S-(N-Methyl- carbamoylmethyl)
Dithiophosphate; O.O-Dimethyl S-(N-Methylcarbamoylmethyl) Phosphorodithioate;
O,O-Dimethyl S-Methylcarbamoylmethyl Phosphorodithioate;
O,O-Dimethyldithiophosphorylacetic Acid, N-Monomethylamide Salt; PEI 75;
Perfecthion; Perfekthion; Phosphamid; Phosphamide; Phosphorodithioic Acid
O,O-Dimethyl Ester, Ester With 2-Mercapto-N-Methylacetamide; Phosphor-
odithioic Acid, O,O-Dimethyl S-(2-(Methylamino)-2-Oxoethyl) Ester; Racusan;
Rogor; Rogor 20L; Rogor 40; Rogor L; Rogor P; Roxion; S-Methylcarbamoylmethyl
O,O-Dimethyl Phosphorodithioate; Sinoratox; Systoate
Chemical Formula: C5H12NO3PS2
Molecular Weight: 229.28
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDBO oral
(mammal) 15 mg/kg (*NIOSH/RTECS 1985).
TPQ: 500/10,000 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 1.277 at 65°C (*Merck 1983)
Vapor Pressure (mmHg): 0.0000085 at 77°F ('Worthing 1979)
Melting Point: 125°F, 52°C (*Merck-1983), 113-117°F, 45-47°C for
technical product (Worthing 1983) .
-------
CAS Registry Number: 60-51-5
Page 2 of 4
DIMETHOATE
SECTION II (continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 2-3 g/100 ml (*Spencer 1982)
Appearance and Odor: A white crystalline solid (*Spencer 1982) with a
camphor-like odor (*Worthing 1979); white to greyish crystals for technical
product (Worthing 1983)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: ADI 0.02 mg/kg (*Hayes 1975).
Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and
Safety 1983)
Skin: Yes (*Encyc Occupat Health and Safety 1983)
Ingestion: Yes (*Encyc Occupat Health and
Safety 1983)
Health Hazards (Acute, Delayed, and Chronic): Very toxic; the probable
oral lethal dose in humans is between 50-500 mg/kg, or between 1 teaspoon
and 1 ounce for a 70 kg (150 Ib.) person. Dimethoate is a cholinesterase
inhibitor, meaning it affects the central nervous system. Death is due to
respiratory arrest arising from failure of respiratory center, paralysis of
respiratory muscles, intense bronchoconstriction or all three (*Gosselin
1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 124°F (CC) (*NFPA 1978)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This material is an organophosphate insecticide
(*White-Stevens 1971; *Worthing 1979). Methods for organophosphorus
pesticides are as follows. Small fires: dry chemical, carbon dioxide,
water spray, and foam. Large fires: water spray, fog, or foam (DOT 1984,
Guide 55).
-------
CAS Registry Number: 60-51-5
Page 3 of 4
DIMETHOATE
SECTION IV (continued)
Special Fire Fighting Procedures: Procedures for organophosphorus
pesticides are as follows. Dike fire control water for later disposal, do
not scatter the material. Wear positive pressure breathing apparatus and
protective clothing. Fight fire from maximum distance (DOT 1984, Guide
55).
Unusual Fire and Explosion Hazards: As with other organophosphorus
pesticides, container may explode in heat of fire (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Spencer 1973)
Conditions to Avoid: The temperature of storage should not exceed
70-80°F. Keep away from sources of heat, flames, or spark-generating
equipment (*Farm Chemicals Handbook 1983). Unstable in alkaline
solution. Hydrolyzed by aqueous alkali. Stable in aqueous solutions.
The compound is stable for 2 years under environmental conditions if
stored in undamaged, original containers (*Spencer 1973).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Dimethoate is a contact and systemic organophosphate insecticide effective
against a broad range of insects and mites when applied on a wide range of
crops (* Worthing 1979; *SRI; * White-Stevens 1971). It has not been
produced in the U.S. since 1982 (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Dimethoate is an organophosphate insecticide (*White-Stevens 1971;
* Worthing 1979). Precautions for organophosphorus pesticides
include the following. Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Ventilate closed spaces before entering them. Remove and
isolate contaminated clothing at the site. Do not touch spilled material;
stop leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible absorbent material
-------
CAS Registry Number: 60-51-5
Page 4 of 4
DIMETHOATE
SECTION VII (continued)
and place into containers for later disposal. Small dry spills: with
clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 60-51-5
Page 1 of 3
Emergency First Aid Treatment Guide
for
DIMETHOATE
(60-51-5)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - White crystalline solid.
Odor - Camphorlike (familiar, fragrant, penetrating).
Commercial Form - White to greyish crystals.
Use - Systemic insecticide-acaricide.
Material to Avoid - Alkali.
Other Names - American Cyanamid 12,880; Cygon; Daphene; Dimet, Dimethogen,
O,O-dimethyl S-methylcarbamoylmethyl phosphorodithioate; Dimeton, Dimevur,
FIP, Fosfotox, Fostion MM, Lurgo, Perfekthion, Phosphamide, Racusan, Rogor,
Roxion, Sinoratox, Systoate.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline
cathartic or sorbitol, normal saline, D5W, Ringer's lactate, atropine,
pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Dimethoate Exposure:
Note: Dimethoate is a cholinesterase inhibitor.
Acute exposure to dimethoate may produce the following signs and symptoms:
pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and
profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may
also occur.
-------
EFATG
CAS Registry Number: 60-51-5
Page 2 of 3
DIMETHOATE
The heart rate may decrease following oral exposure or increase following
dermal exposure. Hypotension (low blood pressure) and chest pain may be noted.
Hypertension (high blood pressure) is not uncommon. Respiratory effects may
include dyspnea (shortness of breath), respiratory depression, and respiratory
paralysis. Psychosis may occur.
Emergency Life-Support Procedures:
Acute exposure to dimethoate may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to dimethoate.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to dimethoate.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
-------
EFATG
CAS Registry Number: 60-51-5
Page 3 of 3
DIMETHOATE
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Activated charcoal may be administered if victims are conscious and
alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4
to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
4. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
5. Transport to a health care facility.
-------
CAS Registry Number: 62-38-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PHENYLMERCURY ACETATE
CAS Registry Number: 62-38-4
Synonyms: (Acetoxymercuri)Benzene; Acetic Acid, Phenylmercury Deriv;
Acetoxyphenylmercury; Agrosan GN 5; Algimycin; Antimucin WDR; Bufen; Ceresan
Universal; Contra Creme; Dyanacide; Femma; FMA; Fungitox OR; Gallotox; HL-331;
Hostaquick; Kwiksan; Leytosan; Liquiphene; Mercury(II) Acetate, Phenyl-;
Mercury, (Acetato)Phenyl-; Mersolite; Mersolite 8; Metasol 30; Norforms;
Phenmad; Phenomercuric Acetate; Phenylmercuriacetate; Phenylmercuric Acetate;
Phix; PMA; PMAC; PMacetate; PMAL; PMAS; Programing Purasan-SC-10; Puraturf 10;
Quicksan 20; Sanitized SPG; SC-110; Shimmerex; Spor-Kil; TAG; Trigosan;
Ziarnik; Mercury,(Acetato-O)Phenyl-
Chemical Formula: C8H8HgO2
Molecular Weight: 336.75
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (rat)
22 mg/kg (*NIOSH/RTECS 1985).
TPQ: 500/10,000 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): In Mercury Compounds category
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): 0.000009 at 35°C (*Worthing 1979)
Melting Point: 300°F, 149°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 62-38-4
Page 2 of 4
PHENYLMERCURY ACETATE
SECTION II (continued)
Solubility in Water: 1 g/180 ml (*Osol 1980); soluble in about 600 parts
water (Merck 1983, p. 1052)
Appearance and Odor: White to creamy white crystalline powder or small
white prisms or leaflets. Odorless (*Osol 1980).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: TWA 0.1 mg/m3 (skin) (*ACGIH 1983)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Hawley 1977)
Skin: Yes (*Hawley 1977)
Ingestion: Yes (*Hawley 1977)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic. The
probable oral lethal dose for humans is 5-50 mg/kg, between 7 drops and 1
teaspoonful for a 70 kg (150 Ib.) person (Gosselin 1984, p. 11-137).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Above 100°F (OC) (*NFPA 1978)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use dry chemical, foam, or carbon dioxide on
solution. Use water as necessary, but run-off should be limited and
controlled to prevent it from entering streams or water supplies (*NFPA
1978).
Special Fire Fighting Procedures: Materials are extremely hazardous to
health, but areas may be entered with extreme care. Full protective
clothing, including self-contained breathing apparatus, rubber gloves,
boots and bands around legs, arms, and waist should be provided. No skin
should be exposed (*NFPA 1978).
Unusual Fire and Explosion Hazards: Fire may produce irritating or
poisonous gases (*DOT 1984).
NFPA Flammability Rating: 1 (powder); 2 (solution)
-------
CAS Registry Number: 62-38-4
Page 3 of 4
PHENYLMERCURY ACETATE
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Phenylmercuric ion is incompatible
with halides, with which precipitates are formed (*Osol 1980).
Hazardous Decomposition or Byproducts: When heated to decomposition, very
toxic mercuric fumes may be given off (Sax 1984, p. 100).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Used as an antiseptic, fungicide, herbicide; mildewcide for paints;
slimicide in paper mills (*Hawley 1977). It was also used in contraceptive
gels and foams (*Osol 1980).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do it without
risk. Use water spray to reduce vapors. Small spills: take up
with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel place
material into clean, dry container and cover; move containers from spill
area. Large spills: dike far ahead of spill for later disposal (*DOT
1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms arising from acute exposure may
occur at varying intervals up to several weeks following exposure.
Ingestion of mercurial fungicide treated grain resulted in gastro-intestinal
irritation with nausea, vomiting, abdominal pain, and diarrhea.
Alkylmercurials produce severe neurologic toxicity, such as loss of feeling
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CAS Registry Number: 62-38-4
Page 4 of 4
PHENYLMERCURY ACETATE
in lips, tongue, and extremities, confusion, hallucinations, irritability,
sleep disturbances, staggering walk, memory loss, slurred speech, auditory
defects, emotional instability, and inability to concentrate. It is also a
strong skin irritant; erythema and blistering may result 6-12 hours after
exposure (*Rumack 1975 to Present). Phenylmercury acetate, at sufficient
concentration, is expected to be injurious to the eye externally (*Grant
1974).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin and eyes with running water for at least 15 minute
Speed in removing material from the skin is of extreme importance. Remo'
and isolate contaminated clothing and shoes at the site. Keep victim quiet
and maintain normal body temperature. Effects may be delayed; keep vict
under observation (DOT 1984, Guide 55).
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CAS Registry Number: 62-53-3
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ANILINE
CAS Registry Number: 62-53-3
Synonyms: Aminobenzene; Aminophen; Aniline Oil; Anyvim; Benzenamine; Benzene,
Amino-; Benzidam; Blue Oil; CI 76000; CI Oxidation Base 1; Cyanol; Krystallin;
Kyanol; NCI-C03736; Phenylamine
Chemical Formula: C6H7N
Molecular Weight: 93.12
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 1,000 (pounds)
RQ: 5,000 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 363-367°F, 184-186°C (*Merck 1976)
Specific Gravity (H2O=1): 1.022 at 20°C/20°C (*Merck 1976)
Vapor Pressure (mmHg): 0.67 at 25°C (*IARC 1972-85)
Melting Point: 21°F, -6.3°C (*Weast 1979)
Vapor Density (AIR=1): 3.22 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 gram in 28.6 mL water (*Merck 1976)
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CAS Registry Number: 62-53-3
Page 2 of 4
ANILINE
SECTION II (continued)
Appearance and Odor: Brown oily liquid (*Student 1981) with an aromatic
amine-like odor ("CHRIS 1978); colorless when freshly distilled (Merck
1983, p. 96)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Air: TWA 5 ppm (19 mg/ms) (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 2 ppm (10 mg/ms) (skin); STEL 5 ppm (20 mg/ms) (skin)
("ACGIH 1982)
IDLH: 100 ppm (NIOSH/OSHA 1978, p. 46)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Merck 1976)
Skin: Yes (*Merck 1976)
Ingestion: Yes (*Merck 1976)
Health Hazards (Acute, Delayed, and Chronic): It is classified as very
toxic. Probable oral lethal dose in humans is 50-500 mg/kg for a 150 Ib.
person. Aniline poisoning is characterized by methemoglobin formation in
the blood and resulting cyanosis or blue skin (*Gosselin 1976). The
formation of methemoglobin interferes with the oxygen-carrying capacity of
the blood (Doull 1980, p. 319). The approximate minimum lethal dose for a
150 Ib. human is 10 grams (*Arena 1979). Serious poisoning may result from
ingestion of 0.25 mL (*Merck 1976).
Medical Conditions Generally Aggravated by Exposure: People at special
, risk-include individuals with glucose-6-phosphate-dehydrogenase deficiency
(*Arena 1979) and those with liver and kidney disorders, blood diseases, or
a history of alcoholism ("General Electric Co. 1978, MSDS #407).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 158°F, 70°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: 1.3% (*NFPA 1978)
UEL: 20-25% (*Sax 1975)
Extinguishing Methods: Use water spray, dry chemical, foam or carbon
dioxide. Use water to keep fire-exposed containers cool (*NFPA 1984).
Special Fire Fighting Procedures: Fight fire from maximum distance. Dike
fire control water for later disposal and do not scatter material (*DOT
1984). If a leak or spill has not ignited, use water spray to control
vapors (*NFPA 1978). Wear self-contained breathing apparatus with a full
face piece operated in pressure-demand or other positive pressure mode
("NIOSH/OSHA 1981) and special protective clothing ("DOT 1984).
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CAS Registry Number: 62-53-3
Page 3 of 4
ANILINE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Combustion can produce toxic fumes
including nitrogen oxides and carbon monoxide (*General Electric Co. 1978,
MSDS #407). Aniline vapor forms explosive mixtures with air (*ITI 1982).
NFPA Flammability Rating: 2
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Heating (*Sax 1975)
Incompatibility (Materials to Avoid): It is incompatible with strong
oxidizers and strong acids (NIOSH/OSHA 1978, p. 46) and a number of other
materials (*Bretherick 1979; *ITI 1982; *Sax 1984).
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits highly toxic fumes (*Sax 1975). These fumes may include nitrogen
oxides and carbon monoxide (General Electric Co. 1978, MSDS #407).
Hazardous Polymerization: May Occur: Yes (*IARC 1972-85)
May Not Occur:
Conditions to Avoid: Polymerizes to a resinous mass (*IARC 1972-85).
SECTION VI - USE INFORMATION
Manufacture of dyes, resins, varnishes, perfumes, shoe blacks, vulcanizing
rubber; solvent (*Merck 1976); inks, paint removers (*Dreisbach 1977);
herbicides, fungicides, explosives, photographic chemicals (*Hawley 1977);
isocyanates (*SRI); and rigid polyurethanes (*NIOSH/OSHA 1981). It is a
chemical intermediate for dyes and pigments and a number of other materials
(*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Shut off ignition sources; no flares, smoking or flames in
hazard area. Do not touch spilled material; stop leak if you can do it
without risk. Use water spray to reduce vapors. Small spills: take up
with sand or other non-combustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (*DOT 1984).
-------
CAS Registry Number: 62-53-3
Page 4 of 4
ANILINE
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl EXCELLENT/MANY
Butyl/Neoprene GOOD/LIMITED
CPE GOOD/LIMITED*
Neoprene POOR/MANY
Nitrile POOR/LIMITED
PE POOR/MANY
PVC POOR/MANY
Saranex GOOD/LIMITED
Teflon GOOD/LIMITED
Viton POOR/MANY
Viton/Neoprene GOOD/LIMITED
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 62-53-3
Page 1 of 3
Emergency First Aid Treatment Guide
for
ANILINE
(62-53-3)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Colorless, oily liquid, or solid below -6 degrees C (21 degrees
F).
Odor - Aromatic, aminelike.
Commercial Form - Brown, oily liquid.
Uses - Manufacture of resins, rigid polyurethane, varnish, perfume, ink, paint
remover, shoe blacks, artificial sweeteners, pesticides, Pharmaceuticals,
photographic chemicals, and optical whitening agents; solvent; analytical
reagent.
Other Names - Aminobenzene, Aminophen, Anyvim, Benzidam, Cyanol, Krystallin,
Kyanol, phenylamine.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, diazepam, phenytoin, dopamine,
levarterenol, methylene blue.
Signs and Symptoms of Acute Aniline Exposure:
Signs and symptoms of acute exposure to aniline may be severe and include
dyspnea (shortness of breath), respiratory paralysis, cardiac arrhythmias, and
cardiovascular collapse. Victims may experience headache, irritability,
disorientation, lethargy, weakness, incoordination, dizziness, and drowsiness.
Delerium, shock, convulsions, and coma may also be observed.
Gastrointestinal effects include dryness of throat, nausea, and vomiting.
Painful urination, oliguria (scanty urination), and hematuria (bloody urine)
may occur. Aniline may irritate the skin, eyes, and mucous membranes; cyanosis
(blue tint to skin and mucous membranes) is a common finding.
-------
EFATG
CAS Registry Number: 62-53-3
Page 2 of 3 v -
ANILINE
Emergency Life-Support Procedures:
Note: Victims at special risk include individuals with glucose-6-phosphate-
dehydrogenase deficiency, those with liver and kidney disorders, blood
diseases, or a history of alcoholism.
Acute exposure to aniline may require decontamination and life support for the
victims. Emergency personnel should wear protective clothing appropriate to
the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to aniline.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to aniline.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas twice with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
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EFATG
CAS Registry Number: 62-53-3
Page 3 of 3
ANILINE
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of aniline is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of aniline may result in sudden onset of seizures or
loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. RUSH to a health care facility.
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CAS Registry Number: 62-73-7
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - DICHLORVOS
CAS Registry Number: 62-73-7
Synonyms: O,O-Dimethyl O-2,2-Dichlorovinyl Phosphate; 2,2-Dichloroethenyl
Phosphoric Acid Dimethyl Ester; 2,2-Dichlorovinyl Dimethyl Phosphate; Atgard;
Bay-19149; Bibesol; Brevinyl; Brevinyl E50; Canogard; Cekusan; Chlorvinphos;
Cyanophos; DDVF; DDVP; DEDEVAP; Deriban; Derribante; Dichlorman; Dichlorovas;
Dichlorovos; Dichlorphos; Dimethyl 2,2-Dichloroethenyl Phosphate; Dimethyl
2,2-Dichlorovinyl Phosphate; Divipan; ENT 20738; Equigard; Equigel; Estrosel;
Ethenol, 2,2-Dichloro-, Dimethyl Phosphate; Fecama; Herkal; Herkol; Krecalvin;
Mafu; Marvex; NCI-COO 113; Nerkol; No-Pest Strip; Nogos; Nuva; O,O-Dimethyl
Dichlorovinyl Phosphate; OMS 14; Phosphoric Acid, 2,2-Dichlorovinyl Dimethyl
Ester; Phosphoric Acid, 2,2-Dichloroethenyl Dimethyl Ester; Phosvit;
Szklarniak; Task; Vapona; Vaponite; 2,2-Dichloroethenyl phosphate; Atgard V;
Brevinyl Weedat 0002; Celcusan; Dichlorophos; Dimethyl dichlorovinyl phosphate;
Nuvan 100 EC; Unifos; Vapona insecticide; Astrobot; Estrosol; Nuvan; SD1750;
Fly fighter; Fly-die; Mopari UN NA 2783; Nogos 50; Nogos G; NSC-6738; OKO; Tap
9vp; Task Tabs; Tenac; UDVF; Unifos 50 EC; Vapona II; Verdican; Verdipor; Vinyl
alcohol, 2,2-Dichloro-, Dimethyl Phosphate; Vinylophos
Chemical Formula: C4H7C12O4P
Molecular Weight: 220.98
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC60 inhalation
(mouse) 0.013 mg/liter/4 hours (*NIOSH/RTECS 1985).
TPQ: 1,000 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 284°F, 140°C at 20 mmHg (*Merck 1976)
Specific Gravity (H2O=1): 1.415 at 25°C/4°C (*Merck 1976)
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CAS Registry Number: 62-73-7
Page 2 of 4
DICHLORVOS
SECTION I (continued)
Vapor Pressure (mmHg): 0.01 at 30°C (*Sunshine 1969)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Approximately 1 g/100 ml (*Merck 1976)
Appearance and Odor: Oily colorless to amber liquid with an aromatic
chemical odor (*Patty 1963; *NIOSH/OSHA 1981)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 1 mg/ms (skin) (NIOSH/OSHA 1978, p. 84)
ACGIH TLV: TWA 0.1 ppm, 1 mg/ms; STEL 0.3 ppm, 3 mg/ms (*AGGIH 1
IDLH: 200 mg/ms (NIOSH/OSHA 1978, p. 84)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): Dichlorvos is a very tox
compound with a probable lethal oral dose in humans between 50 and 50
mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 Ib.) person.
However, brief exposure (30-60 minutes) to vapor concentrations as high
6.9 mg/liter did not result in clinical signs or depressed serum
cholinesterase levels. Toxic changes are typical of organophosphate
insecticide poisoning with progression to respiratory distress, respirator?
paralysis, and death if there is no clinical intervention (Gosselin 1984,
pp. 11-291 and III-336, 337).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Greater than 175°F (no method given) (*>
1978)
Flammable Limits: Moderately flammable (NIOSH/OSHA 1978, p. 84:
ignite easily (*DOT 1984)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Water in flooding quantities as fog, alcohol
dry chemical, or carbon dioxide (NIOSH/OSHA 1978, p. 84). Do not
the material (*DOT 1984).
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CAS Registry Number: 62-73-7
Page 3 of 4
DICHLORVOS
SECTION IV (continued)
Special Fire Fighting Procedures: Use self-contained breathing apparatus
with a full face piece operated on pressure-demand or other positive
pressure mode. Prevent skin contact with protective clothing (*NIOSH/OSHA
1978). Isolate area and deny entry. Fight fire from maximum distance.
Dike fire control water for future disposal (*DOT 1984).
Unusual Fire and Explosion Hazards: Highly toxic chloride fumes or
phosgene may be released when this product burns. Firefighters should take
precautions noted above (*Sax 1979).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Yes (*Encyc Occupat Health and Safety 1971)
Stable:
Conditions to Avoid: Hydrolyzes in water (*Sunshine 1969).
Incompatibility (Materials to Avoid): Corrosive to iron and mild steel
(*Worthing 1979); acids or acid fumes (*Sax 1979).
Hazardous Decomposition or Byproducts: Toxic chloride fumes and phosgene
formed if heated to decomposition or on contact with acid or acid fumes
(*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Agricultural insecticide for use on crops, stored products, animals, and
premises; insecticide for slow release on pest-strips for pest control in
homes and aircraft; anthelmintic for dogs, swine, and horses; botacide for
horses; flea collars for dogs (*Gosselin 1976; *Rossoff 1974; *Worthing
1979; *SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Prevent access to area from public by isolating area and denying entry.
Ventilate closed spaces before entering them. Remove and
isolate contaminated clothing at the site. Do not touch spilled material;
stop leaks if you can do it without risk. Reduce vapors with water spray.
Take up small spills with sand or other noncombustible absorbent material
for later disposal in cannisters. Dike large spills far ahead of spill for
later disposal (*DOT 1984).
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CAS Registry Number: 62-73-7
Page 4 of 4
DICHLORVOS
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Sweating, twitching, contracted pupils,
respiratory distress (tightness in the chest and wheezing), salivation
(drooling), lacrimation (tearing), nausea, vomiting, abdominal cramps,
diarrhea, involuntary defecation and urination, slurred speech, coma, apnea
(cessation of breathing), and death (Doull 1980, pp. 367-368).
Emergency and First Aid Procedures: Call emergency medical care. If
victim was exposed by inhalation, move to fresh air. If not breathing,
give artificial respiration; if breathing is difficult, give oxygen. If
exposure was by contact, flush skin or eyes with running water for at least
15 minutes; it is critical to remove the material from the skin as quickly
as possible. Also remove contaminated clothing and shoes. Victim should
be kept quiet, warm, and observed for delayed effects (*DOT 1984).
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CAS Registry Number: 62-74-8
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - SODIUM FLUOROACETATE
CAS Registry Number: 62-74-8
Synonyms: Acetic Acid, Fluoro-, Sodium Salt; 1080; Compd 1080; Compound No.
1080; Fluoroacetic Acid, Sodium Salt; Fratol; Furatol; Ratbane 1080; SMFA;
Sodium Fluoacetate; Sodium Fluoacetic Acid; Sodium Fluoracetate; Sodium
Monofluoroacetate; Ten-Eighty; TL 869; Yasoknock
Chemical Formula: C2H2FO2Na
Molecular Weight: 100.02
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(guinea pig) 0.1 mg/liter/10 minutes (*NIOSH/RTECS 1985).
TPQ: 10/10,000 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): 0.0 at 20°C (*ACGIH 1980)
Melting Point: 392°F, 200°C (*Weast 1979); decomposes at 392°F, 200°C
(*Hawley 1981)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate** 1): Not Found
Solubility in Water: 1110 g/liter at 25°C (*Weast 1979)
Appearance and Odor: White powder (*Weast 1979); odorless (*Hawley 1981).
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CAS Registry Number: 62-74-8
Page 2 of 3
SODIUM FLUOROACETATE
SECTION II (continued)
Usually marketed as water solution containing 0.5 percent Nigrosine as
black warning color (*Spencer 1982).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.05 mg/m3 (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.05 mg/m3 (skin); STEL 0.15 mg/m3 (skin) (*ACGIH 1983)
IDLH: 5 mg/m3 (NIOSH/OSHA 1978, p. 166)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is super
toxic. The probable oral lethal dose in humans is less than 5 rag/kg, or a
taste (less than 7 drops) for a 150-lb. person (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Not combustible (NIOSH/OSHA 1978, p. 166)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use dry chemical, carbon dioxide, water spray, or
foam. For large fires, use water spray, fog, or foam (*DOT 1984).
Special Fire Fighting Procedures: Stay upwind; keep out of low areas.
Wear self-contained, positive pressure breathing apparatus and full
protective clothing (*DOT 1984).
Unusual Fire and Explosion Hazards*' When heated to decomposition, it
emits highly toxic fumes of sodium oxide and fluorides (*Sax 1984).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NIOSH/OSHA 1978)
*
Conditions to Avoid: Decomposing heat (*Sax 1984)
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CAS Registry Number: 62-74-8
Page 3 of 3
SODIUM FLUOROACETATE
SECTION V (continued)
Incompatibility (Materials to Avoid): None hazardous (NIOSH/OSHA 1978,
p. 166)
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits fumes of sodium oxide and fluorides (*Sax 1984).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
This material is used for control of predatory animals, coyotes, and
rodents (*Farm Chemicals Handbook 1984).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material. Stay upwind; keep out of low areas
(*DOT 1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms include nausea, vomiting,
diarrhea, hyperactive behavior, convulsions, coma, and ventricular
fibrillation. Symptoms are usually seen within one-half hour of exposure,
but severe effects may be delayed as long as 20 hours (*Rumack 1975 to
Present).
Emergency and First Aid Procedures: There is no known specific treatment
for fluoroacetate exposure, but generally symptomatic support should be
provided (*Rumack 1975 to Present). Move victim to fresh air. Call
emergency medical care. Remove and isolate contaminated clothing and shoes
at the site. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes (*DOT 1984).
-------
CAS Registry Number: 62-75-9
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - NITROSODIMETHYLAMINE
CAS Registry Number: 62-75-9
Synonyms: N-Nitrosodimethylamine; Dimethyl Nitrosamine; Dimethylamine,
N-Nitroso-; Dimethylnitrosamine; Dimethylnitrosoamine; DMN; DMNA; Methanamine,
N-Methyl-N-Nitroso-; N,N-Dimethylnitrosamine; N-Methyl-N-Nitrosomethanamine;
N-Nitroso-N,N-Dimethylamine; NDMA
Chemical Formula: C2H6N2O
Molecular Weight: 74.08
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(mouse) 0.173 mg/liter/4 hours (*NIOSH/RTECS 1985).
TPQ: 1,000 (pounds)
RQ: 1 (pounds) (statutory); 10 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 304-307°F, 151-153°C (*Merck 1983)
Specific Gravity (H20=l): 1.0048 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR-1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble (*Merck 1983)
Appearance and Odor: Yellow oily liquid (*IARC 1972-1985); faint
characteristic odor (*Clayton and Clayton 1982)
-------
CAS Registry Number: 62-75-9
Page 2 of 4
NITROSODIMETHYLAMINE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: TWA and STEL: Industrial substance suspected of carcinogenic
potential in humans (*ACGIH 1984)
IDLH: Not Found
Other Limits Recommended: Exposures should be avoided, in so far as
possible, or otherwise be kept to an absolute minimum; suspected of
carcinogenic potential in humans (*ACGIH 1984).
Routes of Entry: Inhalation: Yes ('Sunshine 1969)
Skin: Yes (*Sunshine 1969)
Ingestion: Yes (*Sunshine 1969)
Health Hazards (Acute, Delayed, and Chronic): Extremely high toxicity
(*Sunshine 1969). It is a suspected human carcinogen. The lowest lethal
oral dose in humans has been reported at 10 mg/kg/80 week intermittent
exposure (*NIOSH/RTECS 1985).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Clayton and Clayton 1981, p. 3119)
Conditions to Avoid: Exposure to ultraviolet light (Clayton and
Clayton 1981, p. 3119).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 1984, pp. 1180-1181).
-------
CAS Registry Number: 62-75-9
Page 3 of 4
NITROSODIMETHYLAMINE
•
SECTION V (continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Nitrosodimethylamine was formerly used in the production of rocket fuels.
Presently used as an antioxidant, as an additive for lubricants and as a
softener of copolymers (Merck 1983, p. 952). It is an intermediate for
1,1-dimethylhydrazine (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section III above). Spills can be
absorbed by celite or commercial spill absorbent. After absorbent
containing major share of nitrosamine has been picked-up (avoid dusts; do
not sweep), surface should be thoroughly cleaned with strong detergent
solution. If major spill occurs outside of ventilated area, room should be
evacuated and cleanup operation should be carried out by persons equipped
with self-contained breathing apparatus (*NRC 1981).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
CPE POOR/LIMITED
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms include nausea, vomiting and
malaise (*Cooper 1980). Chronic exposure may cause liver disease with
jaundice and swelling (*Hamilton 1984) with low platelet count ("Cooper
1980).
Emergency and First Aid Procedures: Establish respiration; prevent
absorption; decontaminate with soap and water; for eye exposure, flush with
water (*Rumack 1975 to Present). (Poisonous Liquid or Gas, n.o.s.) Move
-------
CAS Registry Number: 62-75-9
Page 4 of 4
NITROSODIMETHYLAMINE
SECTION IX (continued)
victim to fresh air; call emergency medical care. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush skin or eyes with running water '*
for at least 15 minutes. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 15).
-------
CAS Registry Number: 64-00-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - PHENOL, 3-(l-METHYLETHYL)-, METHYLCARBAMATE
CAS Registry Number: 64-00-6
Synonyms (NIOSH/RTECS, 1983, Volume I, p. 832): Carbamic Acid, Methyl-,
m-Cumenyl Ester; Carbamic Acid, N-Methyl-, 3-Isopropylphenyl Ester; Compound
10854; m-Cumenol Methylcarbamate; m-Cumenyl Methylcarbamate; ENT 25,500; ENT
25,543; H 5727; H 8757; HER. 5727; Hercules 5727; Hercules AC 5727; HIP;
m-Isopropylphenol N-Methylcarbamate; m-Isopropylphenyl Methylcarbamate;
m-Isopropylphenyl N-Methylcarbamate; 3-Isopropylphenyl Methylcarbamate;
N-Methyl m-Isopropylphenyl Carbamate; N-Methyl 3-Isopropylphenyl Carbamatc; QMS
162; 1PC; Phenol, m-Isopropyl-, Methylcarbamate; UC 10854; Union Carbide 10854;
Union Carbide UC-10,854
Chemical Formula: CUH16NO2
Molecular Weight: 193.27
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(guinea pig) 10 mg/kg (*NIOSH/RTECS 1985).
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O»1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 162-165°F, 72-74°C (Hayes 1982, p. 450)
Vapor Density (AIR-1): Not Found
Evaporation Rate (Butyl acetate-1): Not Found
-------
CAS Registry Number: 64-00-6
. „ Page 2 of 4
PHENOL, 3-(l-METHYLETHYL)-, METHYLCARBAMATE
SECTION II (continued)
Solubility in Water: 85 ppm at 30°C (Hayes 1982, p. 450)
Appearance and Odor: Pure white solid without appreciable odor (Hayes
1982, p. 450).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Non-Specific — Carbamate Pesticide,
Solid, n.o.s.) (DOT 1984, Guide 55)
Skin: Yes (Sax 1984, p. 820)
Ingestion: Yes (Sax 1984, p. 820)
Health Hazards (Acute, Delayed, and Chronic): It is a cholinesterase
inhibitor (Hayes 1982, p. 450).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Carbamate Pesticide, Solid,
n.o.s.) Extinguish with dry chemical, carbon dioxide, water spray, fog, or
foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific — Carbamate Pesticide,
Solid, n.o.s.) Wear positive pressure breathing apparatus and special
protective clothing. Move container from fire area if you can do it
without risk. Dike fire control water for later disposal; do not scatter
the material. Fight fire from maximum distance (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific — Carbamate Pesticide,
Solid, n.o.s.) Container may explode in heat of fire (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 64-00-6
Page 3 of 4
PHENOL, 3-(l-METHYLETHYL)-, METHYLCARBAMATE
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Hayes 1982, p. 450)
Conditions to Avoid: Decomposing heat (Sax 1984, p. 820)
Incompatibility (Materials to Avoid): Incompatible with alkalis (Hayes
1982, p. 450).
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 820).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
It is used as an insecticide to protect cotton, fruit, vegetables and field
crops (Farm Chemicals Handbook 1984, p. C-236). Not registered as a
pesticide in the U.S. (USEPA/Pesticide Index 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Carbamate Pesticide, Solid, n.o.s.) Keep unnecessary
people away and stay upwind. Do not touch the material or handle broken
packages without protective clothing. Use water spray to reduce vapors.
Take up spills with non-combustible absorbent material. For small dry
spills, place material in a clean dry container with a clean shovel and
cover; remove from site of spill. For large spills dike far ahead
for later disposal (DOT 1984, Guide 55; Student 1981, p. 104).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Exposure may result in weakness,
dizziness, tightness in the chest, headache, pinpoint pupils, profuse
sweating, blurred vision, stomach pain, vomiting, skin rashes, and
giddiness (Hayes 1982, p. 451).
-------
CAS Registry Number: 64-00-6
Page 4 of 4
PHENOL, 3-(l-METHYLETHYL)-, METHYLCARBAMATE
SECTION IX (continued)
Emergency and First Aid Procedures: (Non-Specific — Carbamate Pesticide,
Solid, n.o.s.) Move victim to fresh air; call emergency medical care. If
not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Remove and isolate contaminated clothing and shoes at the
site. In case of contact with material, immediately flush skin or eyes
with running water for at least IS minutes. Keep victim quiet and maintain
normal body temperature. Effects may be delayed; keep victim under
observation (DOT 1984, Guide 55).
COMMENTS:
Sources searched but no information found:
Weiss 1980
Buchel 1983
Gosselin 1984
Merck 1983
Weast 1979
-------
CAS Registry Number: 64-86-8
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - COLCHICINE
CAS Registry Number: 64-86-8
Synonyms: 7-alpha-H-Colchicine; Acetamide, N-(5,6,7,9-Tetrahydro-1,2,3,10-
Tetramethoxy-9-oxobenzo[a]heptalen-7-yl); Benzo[a]heptalen-9(5H)-one,
7-acetamido-6,7-dihydro-l,2,3,10-tetramethoxy-; Colchicenos; Colchisol; Colcin;
Colsaloid; Condylon; N-Acetyl Trimethylcolchicinic acid, Methyl Ether; NSC 757
Chemical Formula: C22H25NO6
Molecular Weight: 399.43
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDlo oral (dog,
cat) 0.125 mg/kg (*NIOSH/RTECS 1985).
TPQ: 10/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O»1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 288-302°F, 142-150°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g dissolves in 22 ml (*Merck 1976)
Appearance and Odor: Odorless or nearly so (*Hawlcy 1977); pale yellow
needles or powder; darkens on exposure to light (*Merck 1976).
-------
CAS Registry Number: 64-86-8
Page 2 of 3
COLCHICINE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIHTLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): It is classified as super
toxic. Probable oral lethal dose in humans is less than 5 mg/kg, i.e. less
than 7 drops for a 70 kg (150 Ib.) person (*Gosselin 1976). Death results
from respiratory arrest. The fatal dose varies considerably; as little as
7 mg of colchicine has proved fatal (*Goodman 1975).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Slight fire potential (*Sax 1979). Material is a
drug (*SRI), with the following procedures for fires. Extinguish fire
using agent suitable for type of surrounding fire. Use water in flooding
quantities as fog. Use alcohol foam, carbon dioxide or dry chemical
(Student 1981, p. 215).
Special Fire Fighting Procedures: For drugs, solid, n.o.s., avoid
breathing dusts and fumes from burning material. Keep upwind. Wear boots,
protective gloves, and goggles (Student 1981, p. 215).
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Clarke 1975)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
-------
• CAS Registry Number: 64-86-8
Page 3 of 3
COLCHICINE
SECTION V (continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Colchicine is a drug used to treat gouty arthritis, pseudogout, sarcoidal
arthritis and calcific tendinitis (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Precautions for drugs, solid, n.o.s., include the following. Avoid
breathing dusts, and fumes from burning materials. Keep upwind.
Avoid bodily contact with the material. Wear full protective clothing.
Wash away any material which may have contacted the body with
copious amounts of water or soap and water (Student 1981, p. 215).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
>
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Burning of throat and skin are prominent
symptoms. Nausea, vomiting, diarrhea and abdominal pain may occur several
hours after exposure. Shock occurs because of extensive vascular damage.
Kidney damage resulting in bloody urine and diminished urine output may
occur (*Goodman 1975).
Emergency and First Aid Procedures: This material is an alkaloid (Merck
1983, p. 352); first aid for alkaloid exposure is as follows: move victim
to fresh air; call emergency medical care. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case
of contact with material, immediately flush skin or eyes with running water
for at least 15 minutes. Speed in removing material from skin is of
extreme importance. Remove and isolate contaminated clothing and shoes at
the site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 65-30-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - NICOTINE SULFATE
CAS Registry Number: 65-30-5
Synonyms: (S)-3-(l-Methyl-2-Pyrrolidinyl)Pyridine Sulfate (2:1); L-l-
Methyl-2-(3-Pyridyl)-Pyrrolidine Sulfate; L-3-( 1 -Methyl-2-Pyrrolidyl)Pyridine
Sulfate; Black Leaf 40; Nicotine Sulfate, Solid; Nicotine, Sulfate (2:1);
Pyridine, 3-(l-Methyl-2-Pyrrolidinyl)-, (S)-, Sulfate (2:1); Pyrrolidine,
l-Methyl-2-(3-Pyridyl)-, Sulfate
Chemical Formula: (C10H14N2)2.H2SO4
Molecular Weight: 422.56
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(mice) 8.55 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 1.15 at 20°C (solid) (*CHRIS 1978)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR-1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in water (*Merck 1976)
-------
CAS Registry Number: 65-30-5
Page 2 of 4
NICOTINE SULFATE
SECTION II Continued)
Appearance and Odor: A six-sided tablet (*Merck 1976) or white crystals;
(40% solution - Black Leaf Forty) (Hawley 1981, p. 727).
SECTION III - HEALTH HAZARD DATA
OSHA PEL; Not Found
ACGIH TLV: TWA 0.5 mg (nicotineVm3; STEL 1.5 mg (nicotine)/m3 (skin)
(*ACGIH 1982)
IDLH: Not Found
Other Limits Recommended: TWA for nicotine: 0.5 mg/ms (skin) (OSHA 1984,
p. 663).
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): It is classified as super
toxic. Probable oral lethal dose in humans is less than 5 mg/kg (less than
7 drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). Death is possible
from respiratory failure caused by paralysis of the respiratory muscles
(*Goodman 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: As for nicotine, extinguish with alcohol foam, dry
chemical, or carbon dioxide (Sax 1984, p. 1997). Large fires can be
extinguished with water spray, fog, or foam (*DOT 1984).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special protective clothing. Dike fire control water; do not
scatter the material (*DOT 1984).
Unusual Fire and Explosion Hazards: As for nicotine, moderate explosion
hazard when exposed to heat or flame (*Sax 1975).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 65-30-5
Page 3 of 4
NICOTINE SULFATE
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Menzie 1969)
Conditions to Avoid: Decomposing heat (Sax 1984, p. 1998)
Incompatibility (Materials to Avoid): (Non-Specific — Nicotine) Avoid
oxidizing materials (Sax 1984, p. 1997).
Hazardous Decomposition or Byproducts: When heated to decomposition,
emits highly toxic fumes of sulfur oxides and organic fumes (Sax 1984, p.
1998).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
It is used as an insecticide (*Merck 1976) and in veterinary medicine as an
anthelmintic and external parasiticide (*Garner 1967).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
To clean up, do not touch spilled material; stop leak if possible. Use
water spray to reduce vapors. Small spills: take up with sand or other
noncombustible absorbent material and place into containers for disposal.
Small dry spill: with clean shovel place material into clean, dry
container and cover; move containers from spill area. Large spills: dike
far ahead of spill for later disposal (*DOT 1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Onset of acute poisoning is rapid.
Symptoms include nausea, salivation, abdominal pain, vomiting, diarrhea,
cold sweat, headache, dizziness, disturbed hearing and vision, mental
confusion, marked weakness, faintness and prostration, lowered blood
pressure, difficult breathing, and weak, rapid and irregular pulse
(*Goodman 1980). Inhalation irritates nose and throat. The liquid form
irritates the eyes and (on prolonged contact) skin (*CHRIS 1978).
-------
CAS Registry Number: 65-30-5
Page 4 of 4
NICOTINE SULFATE
SECTION IX (continued)
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes.
Speed in removing material from skin is of extreme importance. Remove and
isolate contaminated clothing and shoes at the site. Keep victim under
observation (*DOT 1984).
-------
CAS Registry Number: 66-81-9
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - CYCLOHEXIMIDE
CAS Registry Number: 66-81-9
Synonyms: Glutarimide, 3-(2-(3,5-Dimethyl-2-Oxocyclohexyl)-2- Hydroxycthyl)-;
2,6-Piperidinedione, 4-(2-(3,5-Dimethyl-2-Oxocyclohexyl)- 2-Hydroxyethyl)-
(1S-(1 alpha(S*), 3 alpha, 5 beta))-; Acti-aid; Acti-Dione-PM (-RZ, -BR, & -S);
Actidion; Actidione; Actidione PM; Actispray; beta-(2-(3,5-
Dimethyl-2-Oxocyclohexyl)-2-Hydroxyethyl)Glutarimide; Hizarocin; Kaken;
Naramycin; Naramycin A; Neocycloheximide; NSC-185; TZA; U 4527
Chemical Formula: C15H2SNO4
Molecular Weight: 281.34
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(rat) 2 mg/kg (*NIOSH/RTECS 1985).
TPQ: 100/10,000 (pounds)
•*
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O»1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 247-250°F, 119.5-121 °C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Moderately soluble (Sax 1984, p. 833); 21 g/liter at
36°F, 2°C (*Merck 1976)
-------
CAS Registry Number: 66-81-9
Page 2 of 3
CYCLOHEXIMIDE
SECTION II (continued)
Appearance and Odor: Colorless crystals (*Spencer 1973).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is extremely
toxic; the probable oral lethal dose in humans is 5-50 mg/kg, or 7 drops to
1 teaspoonful for a 150-lb. person (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LELr Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Fungicides, Poison B Solid) Use
agent suitable for surrounding fire. Use alcohol foam, carbon dioxide, or
dry chemical. Use water in flooding quantities as fog (Student 1981, p.
259).
Special Fire Fighting Procedures: (Non-Specific — Fungicides, Poison B
Solid) Avoid breathing dusts and fumes from burning material. Keep
upwind. Wear self-contained breathing apparatus. Avoid bodily contact
with the material. Wear full protective clothing (Student 1981, p. 259).
Unusual Fire and Explosion Hazards: When exposed to heat, it emits toxic
fumes, including nitrogen oxides (Sax 1984, p. 833).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Merck 1976)
-------
CAS Registry Number: 66-81-9
Page 3 of 3
CYCLOHEXIMIDE
SECTION V (continued)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When exposed to heat, it emits
toxic fumes, including nitrogen oxides (Sax 1984, p. 833).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
This material is used as a fungicide (*Merck 1976), and as a medication in
cancer therapy (*Rumack 1975 to Present).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Fungicides, Poison B Solid) Avoid breathing dusts. Keep
upwind. Avoid bodily contact with the material (Student 1981, p. 259).
Material is rapidly inactivated at room temperature by dilute alkali
(*Merck 1976).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 66-81-9
Page 1 of 3
Emergency First Aid Treatment Guide
for
CYCLOHEXIMIDE
(66-81-9)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless crystals.
Commercial Forms - Oil solution, wettable powder, water-soluble tablets.
Uses - Chemotherapy, turf disease control, plant growth regulation, fungicide.
Other Names - Acti-aid, Actidione, Actispray, glutarimide, 3-(2-(3,5-dimethyl-
2-oxocyclohexyl)-2-hydroxyethyl)-; Hizarocin, Kaken, Naramycin A.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
hydrocortisone, atropine.
Signs and Symptoms of Acute Cycloheximide Exposure:
Warning: Effects may be delayed for 6 to 24 hours. Caution is advised.
Signs and symptoms of acute exposure to cycloheximide may include increased
salivation, nausea, vomiting, diarrhea, and dark, bloodstained stools. Dermal
effects may range from erythema (redness) to sloughing. Central nervous system
excitement, including tremor, may be noted. Liver and kidney damage, coma, and
cardiovascular collapse are also possible.
-------
EFATG
CAS Registry Number: 66-81-9
Page 2 of 3
CYCLOHEXIMIDE
Emergency Life-Support Procedures:
Acute exposure to cycloheximide may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to cycloheximide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to cycloheximide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
-------
EFATG
CAS Registry Number: 66-81-9
Page 3 of 3
CYCLOHEXIMIDE
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of cycloheximide is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of cycloheximide may result in sudden onset of
seizures or loss of consciousness. Syrup of Ipecac should be
administered only if victims are alert, have an active gag-reflex, and
show no signs of impending seizure or coma. If ANY uncertainty exists,
proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
-------
CAS Registry Number: 67-66-3
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - CHLOROFORM
CAS Registry Number: 67-66-3
Synonyms: Formyl Trichloride; Freon 20; Methane, Trichloro-; Methane
Trichloride; Methenyl Chloride; Methenyl Trichloride; Methyl Trichloride;
NCI-CO2686; R-20; R 20 (Refrigerant); TCM; Trichloroform; Trichloromethane
Chemical Formula: CHC13
Molecular Weight: 119.39
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 10,000 (pounds)
RQ: 5000 (pounds) (statutory); 10 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 143°F, 61.7°C (*Weast 1979)
Specific Gravity (H2O=1): 1.4832 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 100 at 10.4°C (*Sax 1979)
Melting Point: -82.3°F, -63.5°C (*Weast 1979)
Vapor Density (AIR=1): 4.12 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): (Carbon Tetrachloride = 1) 1.18
('General Electric Co. 1979, MSDS #315)
Solubility in Water: 1 mL/200 mL at 25°C (*Merck 1976)
-------
CAS Registry Number: 67-66-3
Page 2 of 4
CHLOROFORM
SECTION II (continued)
Appearance and Odor: A clear, colorless and mobile liquid with a
characteristic odor (*IARC 1972-1985).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Ceiling 50 ppm (240 mg/m3) (NIOSH 1987, p. 80)
ACGIH TLV: TWA 10 ppm (50 mg/m8) (ACGIH 1986-87, p. 13)
IDLH: 1,000 ppm (NIOSH/OSHA 1978, p. 68)
Other Limits Recommended: NIOSH: 2 ppm 60-minute ceiling; potential
occupational carcinogen (NIOSH 1897, p. 80 and Appendix A). Industrial
substance suspect of carcinogenic potential for humans (ACGIH 1985, p. 42).
EEGL 100.0 ppm (60 minutes) (NRC 1984a, pp. 57-76).
Routes of Entry: Inhalation: Yes (*NIOSH 1974)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*ITI 1982)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
moderately toxic. Probable oral lethal dose for humans is 0.5 to 5 g/kg
(between 1 ounce and 1 pint) for a 150 Ib. person. The mean lethal dose is
probably near 1 fluid ounce (44 g) (*Gosselin 1976). It is a human
suspected carcinogen (*IARC 1972-1985). Also, it is a central nervous
system depressant and a gastrointestinal irritant (*Challen PS et al. 1958.
Br J Ind Med 15:243). It has caused rapid death attributable to cardiac
arrest and delayed death from liver and kidney damage (*IARC 1972-1985).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): None (*General Electric Co. 1979, MSDS #315)
Flammable Limits:
LEL: None ('General Electric Co. 1979, MSDS #315)
UEL: None ('General Electric Co. 1979, MSDS #315)
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog or foam (*DOT 1984).
Special Fire Fighting Procedures: Wear self-contained breathing apparatus
and special protective clothing. Move container from fire area. Fight
fire from maximum distance. Dike fire control water for later disposal; do
not scatter the material (*DOT 1984).
Unusual Fire and Explosion Hazards: Container may explode in the heat of
fire (*DOT 1984). When heated it liberates phosgene (*ITI 1982); hydrogen
chloride, chlorine and toxic and corrosive oxides of carbon and chlorine
('General Electric Co. 1979, MSDS #315).
-------
CAS Registry Number: 67-66-3
Page 3 of 4
CHLOROFORM
SECTION IV (continued)
NFPA Flammability Rating: 0
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*CHRIS 1978)
Conditions to Avoid: It develops acidity from prolonged exposure to
air and light (*General Electric Co. 1979, MSDS #315).
Incompatibility (Materials to Avoid): Chloroform explodes when in contact
with aluminum powder or magnesium powder or with alkali metals (e.g.,
lithium, sodium, and potassium) (*NFPA 1978) and dinitrogen tetroxide. It
reacts vigorously with acetone in the presence of potassium hydroxide or
calcium hydroxide (*Bretherick 1975). It is oxidized by strong oxidizers
such as chromic acid forming phosgene and chlorine (*IARC 1972-1985). It
reacts vigorously with triisopropylphosphine (*Bretherick 1975).
Hazardous Decomposition or Byproducts: When heated, it emits hydrogen
chloride, chlorine, toxic and corrosive oxides of carbon and chlorine
(*General Electric Co. 1979, MSDS #315) and phosgene (*ITI 1982).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
It is used as a grain fumigant; solvent for pesticides, adhesives (*IARC
1972-1985) fats, oils, rubbers, alkaloids, waxes (*Merck 1976); chemical
intermediate for dyes and pesticides; and a component of cough syrups,
toothpastes, and linaments (*SRI). Not registered as a pesticide in the
U.S. (USEPA/Pesticide Index 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING .AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Remote and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do it without risk. Use water
spray to reduce vapors. Small spills: take up with sand or other
non-combustible absorbent materal and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (*DOT
1984).
-------
CAS Registry Number: 67-66-3
Page 4 of 4
CHLOROFORM
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/LIMITED*
Butyl/Neoprene POOR/LIMITED*
CPE POOR/MANY
Neoprene POOR/MANY
Nitrile POOR/MANY
PE POOR/MANY
PVC POOR/MANY
Saranex POOR/MANY
Teflon GOOD/LIMITED
Viton GOOD/LIMITED
Viton/Chlorobutyl GOOD/LIMITED
Viton/Neoprene GOOD/LIMITED*
*Based on qualitative performance information.
"Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms of acute exposure include
fainting sensation, vomiting, dizziness, salivation, nausea, fatigue, and
headache (*ACGIH 1971-1979). Other symptoms are respiratory depression,
coma, kidney damage, and liver damage (*IARC 1972-1985). Liquid in the eye
causes tearing and conjunctivitis (*Grant 1974). Symptoms of chronic
exposure include loss of appetite, hallucinations, moodiness and physical
and mental sluggishness (*NIOSH 1974. Criteria for a recommended standard
occupational exposure to chloroform. DHEW Pub NIOSH 75-114).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes.
Speed in removing material from skin is of extreme importance. Remove and
isolate contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; if0^> victim
under observation (*DOT 1984).
-------
CAS Registry Number: 70-69-9
Page 1 of 3
EPA CHEMICAL PROFILE
Date: June 22, 1987
Revision: November 30, 1987
CHEMICAL IDENTITY - PROPIOPHENONE, 4'-AMINO-
CAS Registry Number: 70-69-9
Synonyms: l-(4-Aminophenyl)-l-Propanone; p-Aminopropiophenone; PAPP;
Paraminopropiophenone; USAF UCTL-1856
Chemical Formula: C9HUNO
Molecular Weight: 149.21
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (cat)
5.6 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O»1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 284°F, 140°C (Merck 1983, p. 70)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (Merck 1983, p. 70)
Appearance and Odor: Yellow needles (Merck 1983, p. 70)
-------
CAS Registry Number: 70-69-9
Page 2 of 3
PROPIOPHENONE, 4'-AMTNO-
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 245)
Health Hazards (Acute, Delayed, and Chronic): Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 70-69-9
Page 3 of 3
PROPIOPHENONE, 4'-AMINO-
SECTION VI - USE INFORMATION
Not Found
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Not Found
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Ingestion of large doses can cause
cyanosis (Sax 1984, p. 245)
Emergency and First Aid Procedures: Not Found
COMMENTS
Sources searched but no information found:
Farm Chemicals Handbook 1984
Hayes 1982
Worthing 1979
Verschueren 1983
Clayton and Clayton 1981-1982
Weiss 1980
Goodman and Oilman 1985
Gosselin 1984
Hawley 1981
-------
CAS Registry Number: 71-63-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - DIGITOXIN
CAS Registry Number: 71-63-6
Synonyms: Acedoxin; Card-20(22)-Enolide, 3-((O-2,6-Dideoxy-beta-D-Ribo-
Hexopyranosyl-(Hexopyranosyl-(l-4)-2,6-Dideoxy-beta-D-Ribo-Hexopyranosyl)oxy)
-14-Hydroxy-, (3beta, 5beta)-; Cardigin; Carditoxin; Cristapurat; Crystalline
Digitalin; Crystodigin; Digilong; Digimed; Digimerck; Digisidin; Digitalin;
Digitaline Cristallisee; Digitaline Nativelle; Digitoksim; Digitophyllin;
Digitoxigenin Tridigitoxoside; Ditaven; Glucodigin; Lanatoxin; Myodigin;
Purodigin; Purpurid; Unidigin
Chemical Formula: C41H64O13
Molecular Weight: 764.92
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (cat)
0.18 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 493-495°F, 256-257°C (when anhydrous) (*Merck 1976)
Vapor Density (AIR=»1): Not Found
Evaporation Rate (Butyl acetate-1): Not Found
Solubility in Water: 1 g in 100 liters at 20°C (*Merck 1976)
-------
CAS Registry Number: 71-63-6
Page 2 of 4
DIGITOXIN
SECTION II (continued)
Appearance and Odor: White or pale buff microcrystalline powder (*Osol
1975); odorless (Merck 1983, p. 353)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Material is bioactive and
capable of causing cardiac arrythmias and electrolyte imbalances that may
be fatal. Death is due to ventricular fibrillation or cardiac standstill
(*Gosselin 1976). Material has a high toxicity hazard rating; it may cause
death or permanent injury after a very short exposure (*Sax 1979). It is
classified as super toxic; an estimated single lethal dose is 3-10 mg
(Gosselin 1984, p. 11-252).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Drugs or Medicines, Solid,
n.o.s.) Extinguish fire using agent suitable for type of surrounding fire
(material itself burns with difficulty.) Use water in flooding quantities
as fog. Use alcohol foam, carbon dioxide or dry chemical (Student 1981,
p. 215).
Special Fire Fighting Procedures: (Non-Specific — Drugs or Medicines,
Solid, n.o.s.) Avoid breathing dusts and fumes from burning material.
Keep upwind. Wear boots, protective gloves, and goggles (Student 1981, p.
216).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits acrid smoke and irritating fumes (Sax 1984, p. 1035).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 71-63-6
Page 3 of 4
DIGITOXIN
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Material is a cardiotonic drug (*Goodman 1975).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Drugs or Medicines, Solids, n.o.s.) Keep upwind.
Avoid bodily contact with the material. Wear full protective clothing.
Wash away any material which may have contacted the body with copious
amounts of water or soap and water (Student 1981, p. 216).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Nausea and vomiting, headache, malaise,
fatigue, weakness, drowsiness, abdominal discomfort are symptomatic of
toxicity. Visual disturbances (reduction in visual acuity, illusions of
flickering or shimmering lights, abnormal color vision) and emotional
disorders (including confusion, disorientation, aphasia, delirium,
hallucinations, and rarely convulsions) are also possible toxic effects
(*Gosselin 1976; *Grant 1974).
Emergency and First Aid Procedures: (Non-Specific -- Medicines, n.o.s.)
Move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen. In
case of contact with material, immediately flush skin or eyes with running
water for at least IS minutes. Remove and isolate contaminated clothing
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CAS Registry Number: 71-63-6
Page 4 of 4
DIGITOXIN
SECTION IX (continued)
and shoes at the site. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 11).
-------
CAS Registry Number: 72-20-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ENDRIN
CAS Registry Number: 72-20-8
Synonyms: 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-Hexachloro-6,7-Epoxy-
l,4,4a,5,6,7,8,8a-Octahydro-,endo,endo-; Compound 269; Endrex; Endricol; ENT
17,251; Experimental Insecticide 269; Hexachloroepoxyoctahydro-endo,endo-
Dimethanonaphthalene; Hexadrin; Mendrin; NCI-C00157; SD 3419; Oktanex; EN 57;
2,7:3,6-Dimethanonaphth[2,3-b]Oxirene, 3,4,5,6,9,9-Hexachloro-1 a,2,2a,
3,6,6a,7,7a-Octahydro-, (la.alpha., 2.beta., 2a.beta., 3.alpha., 6.alpha.,
6a.beta., 7.beta., 7a.alpha.)-; Nendrin; 1,2,3,4,10,10-Hexachloro-6,7-epoxy-
l,4,4a,5,6,7,8,8a-octahydro-endo,endo-l,4:5,8-dimethanonaphthalene; 1,2,3,4,
10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo-1,4-endo-5,8-
dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-
octahydro-l,4:5,8-endo,endo-dimethanonaphthalene; NCI 01565; C00157; Isodrin
Epoxide; Endrical
Chemical Formula: C12H8C16O
Molecular Weight: 380.90
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(mouse) 1.37 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 1.7 at 68°F, 20°C (*USEPA 1980)
Vapor Pressure (mmHg): 0.0000002 at 77°F, 25°C (*Worthing 1979)
Melting Point: Decomposes at 473°F, 245°C (Merck 1983, p. 517)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 72-20-8
Page 2 of 4
ENDRIN
SECTION II (continued)
Evaporation Rate (Butyl acetate-1): Not Found
Solubility in Water: Practically insoluble (*IARC 1972-1985)
Appearance and Odor: White, crystalline solid; light tan color for
technical grade (*NFPA 1978). Odorless ("CHRIS 1978) or mild chemical odor
for technical grade (*IARC 1972-1985).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.1 mg/m3 (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.1 mg/m3 (skin) (ACGIH 1986-87, p.18)
IDLH: 200 mg/m3 (*NIH EPA, OHM/TADS 1984)
Other Limits Recommended: STEL 0.5 mg/m3 for 30 minutes (Weiss 1980, p.
402)
Routes of Entry: Inhalation: Yes ("USEPA 1980)
Skin: Yes (*NFPA 1978)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is extremely
toxic (*Gosselin 1976). It is rapidly absorbed through the skin (*NFPA
1978). Symptoms appear between 20 minutes and 12 hours after exposure
(*Gosselin 1976). There is evidence that this material may cause
chromosomal damage (*USEPA 1980). Doses of 1 mg/kg can cause symptoms (Sax
1984, p. 1278). It is a suspected carcinogen (Hawley 1981, p. 410). Also,
it is a central nervous system depressant and hepatotoxin (Farm Chemicals
Handbook 1984, p. C-93).
Medical Conditions Generally Aggravated by Exposure: Pregnant women are
considered to be at special risk (*USEPA 1980).
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Commercial product may contain flammable
liquid with flashpoint 80°F, 27°C (*NIH EPA, OHM/TADS 1984)
Flammable Limits:
LEL: 1.1% (commercial product) (Weiss 1980, p. 402)
UEL: 7.0% (commercial product) (Weiss 1980, p. 402)
Extinguishing Methods: Use dry chemical, foam, carbon dioxide ("CHRIS
1978), water spray for solution (*NFPA 1978). Small fires: dry chemical,
carbon dioxide, water spray, or foam. Large fires: water spray, fog, or
foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Use water to keep fire-exposed
containers cool (*NFPA 1978). Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Ventilate closed
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CAS Registry Number: 72-20-8
Page 3 of 4
ENDRIN
SECTION IV (continued)
spaces before entering them. Wear positive pressure breathing apparatus
and special protective clothing. Remove and isolate contaminated clothing
at the site. Move container from fire area if you can do it without risk.
Fight fire from maximum distance. Dike fire control water for later
disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Toxic hydrogen chloride and phosgene
may be generated when solution burns (*CHRIS 1978).
NFPA Flammability Rating: 1 (solution); 0 (dry)
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*USEPA 1980)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Strong oxidizers, strong acids
(*NIH EPA, OHM/TADS 1984), and parathion (Sax 1984, p. 1279)
Hazardous Decomposition or Byproducts: Toxic hydrogen chloride and
phosgene may be generated when solutions burn (*CHRIS 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not found
SECTION VI - USE INFORMATION
This material is used primarily as an insecticide for field crops
(*Worthing 1979). Only cotton and bird perch uses registered in the U.S.
(USEPA/Pesticide Index 1985).
SECTION VII ~ PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
For leaks or spills, use water spray to disperse vapor and to flush spills
(*NFPA 1978). Liquid containing this material should be absorbed in
vermiculite, dry sand, earth (*NIOSH/OSHA 1981). Do not touch spilled
material; stop leak if you can do it without risk. Small dry spills: with
clean shovel place material into clean, dry container and cover; move con-
tainers from spill area. Large spills: dike far ahead of spill for later
disposal. Keep unnecessary people away; isolate hazard area and deny
entry. Ventilate closed spaces before entering them. Remove and
isolate contaminated clothing at the site (DOT 1984, Guide 55).
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CAS Registry Number: 72-20-8
Page 4 of 4
ENDRIN
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: It can cause death by respiratory arrest.
Symptoms include headache, nausea, vomiting, dizziness, tremors,
convulsions, loss of consciousness, rise in blood pressure, fever, frothing
of the mouth, deafness, coma, and death (*Gosselin 1976, Gosselin 1984, pp.
11-285, III-143).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes.
Speed in removing material from skin is of extreme importance. Remove and
isolate contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
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CAS Registry Number: 74-83-9
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - METHYL BROMIDE
CAS Registry Number: 74-83-9
Synonyms: Brom-o-gas; Bromomethane; Curafume; Dowfume MC-2 Soil Fumigant;
Dowfume MC-33; Edco; Embafume; Halon 1001; Haltox; Iscobrome; Kayafume; MB;
MBX; MEBR; Metaf ume; Methane, Bromo-; Methogas; Monobromomethane; Pestmaster;
Prof ume; R 40B1; Rotox; Terabol; Terr-o-gas 100; Zytox
Chemical Formula: CH3Br
Molecular Weight: 94.95
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 1,000 (pounds)
RQ: 1,000 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Gas
Boiling Point: 38.4°F, 3.56°C (*Weast 1979)
Specific Gravity (H2O=1): Liquid: 1.730 at 0°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 1420 at 20°C (*Merck 1976)
Melting Point: -136°F, -93.6°C (*Merck 1976)
Vapor Density (AIR»1): 3.27 (*NFPA 1978)
Evaporation Rate (Butyl acetate=»l): Not Found
Solubility in Water: 1.34 g/100 g at 25°C (*Worthing 1979)
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CAS Registry Number: 74-83-9
Page 2 of 4
METHYL BROMIDE
SECTION II (continued)
Appearance and Odor: Colorless gas; usually odorless, but has a sweetish
chloroform-like odor at high concentrations (*Merck 1976).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Ceiling Concentration 80 mg/ms (20 ppm) (NIOSH 1987,p. 158)
ACGIH TLV: TWA 20 mg/ms (5 ppm) (ACGIH 1986-87, p.23)
IDLH: 2,000 ppm (NIOSH/OSHA 1978, p. 126)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Gosselin 1976)
Skin: Yes (*Gosselin 1976)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Methyl bromide is a
dangerous cumulative poison with delayed symptoms of central nervous system
intoxication that may appear as long as several months after exposure
(*White-Stevens 1971). High concentrations can produce fatal pulmonary
edema. Chronic exposure can cause central nervous system depression and
kidney injury (*Merck 1976). It may cause severe and permanent brain
damage. Severe neurological signs may appear when there is a sudden
exposure to high concentrations following continuous slight exposure
(*Encyc Occupat Health and Safety 1971). Methyl bromide has practically no
odor or irritating effects and therefore no warning, even at hazardous
concentrations (*Clayton and Clayton 1981-82).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): None (*Sax 1979)
Flammable Limits:
LEL: 10% (*Sax 1979)
UEL: 16% (*Sax 1979)
Extinguishing Methods: Non-flammable in air; burns in oxygen (*Merck
1976). Use water spray, foam, carbon dioxide, or dry chemical (*NFPA
1978).
Special Fire Fighting Procedures: Full protective clothing, including
self-contained breathing apparatus, coat, pants, gloves, boots, and bands
around legs, arms, and waist should be provided. No skin surface should be
exposed (*NFPA 1978). Move container from fire area if you can do it
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of bromides (*Sax 1979).
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CAS Registry Number. 74-83-9
Page 3 of 4
METHYL BROMIDE
SECTION IV (continued)
NFPA Flammability Rating: 1
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits toxic fumes of bromides (*Sax 1979).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 603)
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
This material is used as an insecticide, rodenticide, fumigant, and
nematocide; as a chemical intermediate (*SRI); and as a fire extinguishing
agent (""Clayton and Clayton 1981-82).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Remove all ignition sources. Ventilate area of spill or leak,
stop flow of gas or remove leaking cylinder to open air and
repair leak or allow cylinder to empty. If material is in the
liquid form, allow it to vaporize (*NIOSH/OSHA 1981). Stay
upwind, keep out of low areas. Use water spray to reduce vapors
(DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/LIMITED*
Neoprene GOOD/LIMITED*
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CAS Registry Number: 74-83-9
Page 4 of 4
METHYL BROMIDE
SECTION VIII (continued)
Nitrile GOOD/LIMITED*
PE POOR/LIMITED
PVC POOR/LIMITED*
Saranex GOOD/LIMITED
Viton GOOD/LIMITED*
*Based on qualitative performance information.
"Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 74-83-9
Page 1 of 3
Emergency First Aid Treatment Guide
for
METHYL BROMIDE
(74-83-9)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Colorless, transparent, easily liquefied gas, or volatile liquid.
Odor - Usually odorless, chloroformlike odor at higher concentrations.
Commercial Forms - 98% pure liquid or gas in steel cylinders.
Uses - Organic synthesis, fumigation, fire extinguishing, oil extraction from
organic matter, pesticides, ionization chambers.
Materials to Avoid - Metals, oxidizers.
Other Names - Bromomethane, Curafume, Dowfume, Embafume, Haltox, Iscobrome,
Kayafume, Metafume, Methogas, Monobromomethane, Pestmaste, Profume, Rotox,
Terabol, Zytox.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, normal saline, D5W,
Ringer's lactate, dimercaprol, diazepam, phenytoin, phenobarbital,
aminophylline, furosemide.
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EFATG
CAS Registry Number: 74-83-9
Page 2 of 3
METHYL BROMIDE
Signs and Symptoms of Acute Methyl Bromide Exposure:
Warning: Effects may be delayed for hours to days. Caution is advised.
Signs and symptoms of acute exposure to methyl bromide may be severe and
include tremors, convulsions, brain hemorrhage, paralysis, coma, and permanent
brain damage. Respiratory effects include cough, tachypnea (rapid respiratory
rate), pulmonary edema, and respiratory collapse. Cyanosis (blue tint to the
skin and mucous membranes), pallor, ventricular fibrillation, and circulatory
collapse may also occur. Lethargy, profound weakness, headache, dizziness,
mental confusion, slurring of speech, staggering gait, and blurred or double
vision are often found.
Gastrointestinal signs and symptoms include nausea, vomiting, abdominal pain,
and anorexia. Oliguria (scanty urination), anuria (lack of urine formation),
kidney hemorrhage, and kidney failure may occur. Contact with methyl bromide
may cause dermatitis (red, inflamed skin) and conjunctivitis (red, inflamed
eyes).
Emergency Life-Support Procedures:
Acute exposure to methyl bromide may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to methyl bromide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other, invasive
procedures.
4. Transport to a health care facility.
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EFATG
CAS Registry Number: 74-83-9
Page 3 of 3
METHYL BROMIDE
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to methyl bromide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas twice with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
Ingestion Exposure: No information is available.
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CAS Registry Number: 74-90-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - HYDROCYANIC ACID
CAS Registry Number: 74-90-8
Synonyms: Hydrogen Cyanide; Prussic Acid; Aero Liquid HCN; Cyclon; Cyclone
B; Evercyn; Formic Anammonide; Formonitrile; Zaclondiscoids
Chemical Formula: HCN
Molecular Weight: 27.03
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(mouse) 0.357 mg/liter/5 minutes (*NIOSH/RTECS 1985)
TPQ: 100 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Gas
Boiling Point: 78.1°F, 25.6°C (*Merck 1976)
Specific Gravity (H2O«1): 0.699 (liquid) (*Weast.l983)
Vapor Pressure (mmHg): 630 (*White-Stevens 1971)
Melting Point: 7.9°F, -13.4°C (*Merck 1983)
Vapor Density (AIR-1): 0.901 g/1 (*Weast 1983)
Evaporation Rate (Butyl acetate=»l): Not Found
Solubility in Water: Miscible with water (*Merck 1976)
Appearance and Odor: Colorless gas or liquid; bitter almond odor (*Merck
1976; *CHRIS 1978)
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CAS Registry Number: 74-90-8
Page 2 of 4
HYDROCYANIC ACID
SECTION III - HEALTH HAZARD DATA
OSHA PEL: 10 ppm (11 mg/m3), as cyanide (NIOSH 1987 p. 138)
ACGIH TLV: Ceiling 10 mg/m3 (10 ppm) (skin) (ACGIH 1986-87 p. 20)
IDLH: 50 ppm, as cyanide (NIOSH 1987, p. 138)
Other Limits Recommended: NIOSH: 5 mg/m3 (4.7 ppm) (CN) 10 minute ceiling
(NIOSH 1987, p. 138)
Routes of Entry: Inhalation: Yes (*Goodman 1975)
Skin: Yes (*Encyc Occupat Health and Safety 1983)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): It is super toxic.
Breathing in a small amount of the gas or swallowing a very small amount
may be fatal (*NFPA 1978; *Gosselin 1976). Average fatal dose is 50-60 mg.
A few minutes of exposure to 300 ppm may result in death. Exposure to 150
ppm for 1/2 to 1 hour may endanger life (Merck 1983, p. 696).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 0°F, -18°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: 5.6% (*NFPA 1978)
UEL: 40.0% (*NFPA 1978)
Extinguishing Methods: Use dry chemicals, alcohol foam, or carbon dioxide
(*NFPA 1978). Small fires: let burn unless leak can be stopped
immediately. Large fires: water spray, fog or foam. Move container from
fire area if you can do it without risk. Stay away from ends of tanks.
Withdraw immediately in case of rising sound from venting safety device or
any discoloration of tank due to fire. Cool container with water using
unmanned device until well after fire is out. Isolate area until gas has
dispersed (*DOT 1984).
Special Fire Fighting Procedures: Firefighting should be done from a safe
distance. A few whiffs of gas, or liquid penetrating firefighter's
protective clothing, could be fatal. Only special protective clothing
should be worn. Water spray should be used to keep containers cool (*NFPA
1978). Keep unnecessary people away; isolate hazard area and deny entry.
Stay upwind; keep out of low areas. Ventilate closed spaces before
entering them. Wear positive pressure breathing apparatus and special
protective clothing. Evacuate area endangered by gas. Isolate for 1/2
mile in all directions if tank car or truck is involved in fire (*DOT
1984).
Unusual Fire and Explosion Hazards: Unstabilized hydrocyanic acid may
polymerize spontaneously with explosive violence (*Hawley 1981). Flashback
along vapor trail may occur (*CHRIS 1978). The explosion hazard is severe
when this material is exposed to heat, flame, or oxidizers (*Sax 1975). It
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CAS Registry Number: 74-90-8
Page 3 of 4
HYDROCYANIC ACID
SECTION IV (continued)
forms explosive mixtures with air, and will react with water, steam, acid,
or acid fumes to produce highly toxic fumes of cyanides. It may decompose
explosively upon contact with alkaline material (Sax 1984, p. 1548).
NFPA Flammability Rating: 4
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*Hawley 1981)
Stable:
Conditions to Avoid: Hydrocyanic acid solution is sensitive to light
(*Hawley 1977). It may become unstable and subject to explosion if
stored for an extended time or exposed to high temperature and pressure
("CHRIS 1978). Avoid heat, flame or oxidizers (Sax 1984, p. 1548).
Incompatibility (Materials to Avoid): Acetylaldehyde, alkaline materials,
oxidizers, water, steam, acid, and acid fumes (Sax 1984, p. 1548)
Hazardous Decomposition or Byproducts: Toxic cyanide fumes (Sax 1984, p.
1548)
Hazardous Polymerization: May Occur: Yes (*Hawley 1981)
May Not Occur:
Conditions to Avoid: Unstabilized hydrocyanic acid may polymerize
spontaneously with explosive violence (*Hawley 1981). Can polymerize
at 50-60°C or when catalyzed with traces of alkali (Sax 1984, p.
1548).
SECTION VI - USE INFORMATION
j Hydrogen cyanide is used as a rodent poison and as a fumigant (*Rossoff
*1974). It is a chemical intermediate in the manufacture of acrylates,
methacrylates, hexamethylenediamine, nitriles, and other materials (*Patty
1963). It is also used in metal polishes, electroplating solutions, and
metallurgical and photographic processes (*Gosselin 1976).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Stay upwind; keep out of low areas. Ventilate closed spaces before
entering. Use water spray to reduce vapors. Do not touch spilled
material; stop leak if you can do it without risk. Shut off ignition;
no flares, smoking, or flames in hazard area. Isolate area until gas
dispersed (*DOT 1984)
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.CAS Registry Number: 74-90-8
Page 4 of 4
HYDROCYANIC ACID
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED
Neoprene GOOD/LIMITED*
PE GOOD/LIMITED
PVC POOR/LIMITED
Viton GOOD/LIMITED*
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 74-90-8
Page 1 of 4
Emergency First Aid Treatment Guide
for
HYDROCYANIC ACID (HYDROGEN CYANIDE)
(74-90-8)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Caution: Hydrocyanic acid toxicity can occur via ingestion, dermal/eye
contact, or inhalation; death may occur within minutes. IMMEDIATELY begin
administering 100% oxygen and RUSH victims to a health care facility.
Substance Characteristics:
Pure Forms - Colorless gas or water-white liquid below -13 degrees C
(8 degrees F).
Odor - Bitter, almondlike.
Commercial Forms - 96 to 99% pure in 2, 5, and 10% solutions with a stabilizer
in bottles, steel cylinders, and tank cars.
Uses - Rodenticide, fumigant, . chemical intermediate, metallurgy and
photography, constituent in metal polishes and electroplating solutions.
Other Names - Cyclon, formonitrile, hydrogen cyanide, prussic acid.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline
cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote
kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium
bicarbonate, diazepam, phenytoin.
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EFATG
CAS Registry Number: 74-90-8
Page 2 of 4
HYDROCYANIC ACID (HYDROGEN CYANIDE)
Signs and Symptoms of Acute Hydrocyanic Acid Exposure:
Warning: Hydrocyanic acid may be fatal if inhaled, swallowed, or absorbed
through skin or mucous membranes.- Caution is advised.
Signs and symptoms of acute exposure to hydrocyanic acid may include
hypertension (high blood pressure) and tachycardia (rapid heart rate), followed
by hypotension (low blood pressure) and bradycardia (slow heart rate). Cherry
red mucous membranes and blood may be noted. Cardiac arrhythmias and other
cardiac abnormalities are common. Cyanosis (blue tint to the skin and mucous
membranes) may be observed.
Weakness, headache, vertigo (dizziness), agitation, giddiness, salivation,
nausea, and vomiting, may be followed by combative behavior, convulsions,
paralysis, protruding eyeballs, dilated and unreactive pupils, and coma.
Tachypnea (rapid, shallow respirations) or hyperpnea (rapid, deep respirations)
may be followed by respiratory depression. Lung hemorrhage and pulmonary edema
may also occur.
Hydrocyanic acid is may be irritating to the skin, eyes, and mucous membranes.
Lacrimation (tearing) and a burning sensation of the mouth and throat are
common.
Emergency Life-Support Procedures:
Acute exposure to hydrocyanic acid may require decontamination and life support
for the victims. All exposed persons should be transported to a health care
facility as quickly as possible. Emergency personnel should wear protective
clothing appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to hydrocyanic acid.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use
a forced-oxygen mask. Direct oral contact with hydrocyanic acid-
contaminated persons or their gastric contents can result in self-
poisoning.
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CAS Registry Number: 74-90-8
Page 3 of 4
HYDROCYANIC ACID (HYDROGEN CYANIDE)
3. RUSH to a health care facility!
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to hydrocyanic acid.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use
a forced-oxygen mask. Direct oral contact with hydrocyanic acid-
contaminated persons or their gastric contents can result in self-
poisoning.
3. RUSH to a health care facility!
4. Remove contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
6. Wash exposed skin areas twice with soap and water.
7. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen mask. Direct oral contact with hydrocyanic acid-
contaminated persons or their gastric contents can result in self-
poisoning.
2. RUSH to a health care facility!
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CAS Registry Number: 74-90-8
Page 4 of 4
HYDROCYANIC ACID (HYDROGEN CYANIDE)
3. DO NOT induce vomiting or attempt to neutralize!
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
5. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of
cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
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CAS Registry Number: 74-93-1
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - METHYL MERCAPTAN
CAS Registry Number: 74-93-1
Synonyms: Mercaptomethane; Methanethiol; Methyl Sulfhydrate; Thiomethanol;
Thiomethyl Alcohol
Chemical Formula: CH4S
Molecular Weight: 48.11
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LCSO inhalation
(mouse) 0.0065 mg/liter/2 hours (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Gas
Boiling Point: 42.7°F, 5.95°C (*Merck 1983)
Specific Gravity (H2O=1): 0.8665 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 1 at -90.7°C; 10 at -67.5°C; 40 at -49.2°C; 100 at
-34.8°C; 400 at -7.9°C; 760 at 6.8°C (*Weast 1979)
Melting Point: -189.4°F, -123°C (*Merck 1983)
Vapor Density (AIR-1): 1.66 (*Sax 1984)
Evaporation Rate (Butyl acetates!): Not Found
Solubility in Water: 23.30 g/liter (*Merck 1983)
Appearance and Odor: Water-white liquid when below boiling point, or
colorless gas (*Hawley 1981); odor of rotten cabbage (*Merck 1983)
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CAS Registry Number: 74-93-1
Page 2 of 4
METHYL MERCAPTAN
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Ceiling 20 mg/ms (10 ppm) 15 minute (NIOSH/OSHA 1978, p.
130)
ACGIH TLV: TWA 1 mg/m3 (0.5 ppm) (*ACGIH 1983)
IDLH: 400 ppm (*Encyc Occupat Health and Safety 1983)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 618)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Can cause death by
respiratory paralysis (*ACGIH 1980). It is an eye and respiratory tract
irritant. Exposure results in pulmonary edema and hepatic and renal damage
(Clayton and Clayton 1981-82, p. 2067).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 0°F, -18°C (*Sunshine 1969)
Flammable Limits:
LEL: 3.9% (Weiss 1980, p. 618)
UEL: 21.8% (Weiss 1980, p. 618)
Extinguishing Methods: Small fires: let burn unless leak can be stopped
immediately. Large fires: water spray, fog, or foam. Move container from
fire area if you can do so without risk. Stay away from ends of tanks.
Withdraw immediately in case of rising sound from venting safety device or
any discoloration of tank due to fire. Cool container with water using
unmanned device until well after fire is out. Isolate area until gas has
dispersed (DOT 1984, Guide 13). Preferably let fire burn, stop gas flow.
Fires may be extinguished with dry chemical, foam, or carbon dioxide (Weiss
1980, p. 618).
Special Fire Fighting Procedures: Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Evacuate area endangered by
gas. Isolate for 1/2 mile in all directions if tank car or truck is
involved in fire (DOT 1984, Guide 13).
Unusual Fire and Explosion Hazards: Combustion produces irritating sulfur
dioxide. Flash back along vapor track may occur (*CHRIS 1978), Very
dangerous when exposed to heat, flame, or oxidizers. On decomposition it
emits highly toxic fumes of sulfur oxides. It will react with water, steam
or acids to produce toxic and flammable vapors; and can react vigorously
with oxidizing materials (Sax 1984, p. 1764).
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CAS Registry Number: 74-93-1
Page 3 of 4
METHYL MERCAPTAN
SECTION IV (continued)
NFPA Flammability Rating: 4
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*CHRIS 1978)
Conditions to Avoid: Direct sunlight, and areas of high fire hazards
(*Sax 1968)
Incompatibility (Materials to Avoid): Incompatible with mercuric oxide
and oxidizing materials (Sax 1984, p. 1764).
Hazardous Decomposition or Byproducts: Irritating sulfur dioxide is
produced upon combustion (Weiss 1980, p. 618). When heated to
decomposition, it emits highly toxic fumes and flammable vapors (Sax 1984,
p. 1764).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 618)
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Manufacturing of pesticides (*Merck 1983); chemical intermediate for
Pharmaceuticals; dimethyl sulfide; fungicides; methionine; in jet fuels; in
preparation of plastics (*SRI); and as a gas odorant to serve as a warning
property for odorless but hazardous gases (*Clayton and Clayton 1981-82).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Do not touch spilled material; stop leak if you can do so
without risk. Shut off ignition sources; no flares, smoking, or flames in
hazard area. Use water spray to reduce vapors. Isolate, area until gas has
dispersed (DOT 1984, Guide 13). Avoid breathing vapors (see Section III
above).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
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CAS Registry Number: 74-93-1
Page 4 of 4
METHYL MERCAPTAN
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 74-93-1
Page 1 of 4
Emergency First Aid Treatment Guide
for
METHYL MERCAPTAN
(74-93-1)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Colorless gas, or water-white liquid below 6 degrees C
(43 degrees F) or under pressure.
Odor - Similar to rotten cabbage.
Commercial Form - 98% pure liquefied gas in 180-lb cylinders or tank cars.
Uses - Manufacture of pesticides, fungicides, Pharmaceuticals, methionine,
dimethyl sulfide, plastics, jet fuels, gas odorant for odorless but hazardous
gases.
Materials to Avoid - Mercuric oxide, oxidizers, bleaches.
Caution: Highly flammable. Cylinders may explode when exposed to high
temperatures or fire. Avoid sources of extreme heat or ignition including
sparks or fire. Combustion produces irritating sulfur oxides.
Other Names - Mercaptomethane, methanethiol, methyl sulfhydrate, thiomethanol,
thiomethyl alcohol.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
diazepam, phenytoin, dopamine, amyl nitrite, sodium nitrite, atropine.
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EFATG
CAS Registry Number: 74-93-1
Page 2 of 4
METHYL MERCAPTAN
Signs and Symptoms of Acute Methyl Mercaptan Exposure:
Warning: Effects may be delayed. Caution is advised.
Signs and symptoms of acute exposure to methyl mercaptan may include fever,
cough, shortness of breath, a feeling of tightness and burning in the chest,
pulmonary edema, respiratory distress, respiratory paralysis, and respiratory
failure/collapse.
Headache, loss of the sense of smell, dizziness, staggering gait, and
heightened emotions may occur. Memory loss, damage to the central and
peripheral nervous systems, tremor, convulsions, and coma may also occur.
Gastrointestinal symptoms include difficulty swallowing, redness of the tongue
and pharynx, nausea, vomiting, abdominal pain, and diarrhea. Urinary
disturbances may also be found. Methyl mercaptan may irritate the eyes and
mucous membranes.
Emergency Life-Support Procedures:
Acute exposure to methyl mercaptan may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to methyl mercaptan.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to methyl mercaptan.
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EFATG
CAS Registry Number: 74-93-1
Page 3 of 4
METHYL MERCAPTAN
,*
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of methyl mercaptan is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of methyl mercaptan may result in sudden onset of
seizures or loss of consciousness. Syrup of Ipecac should be
administered only if victims are alert, have an active gag-reflex, and
show no signs of impending seizure or coma. If ANY uncertainty exists,
proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
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EFATG
CAS Registry Number: 74-93-1
Page 4 of 4
*
METHYL MERCAPTAN
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. RUSH to a health care facility.
-------
CAS Registry Number: 75-15-0
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- CARBON DISULFIDE
CAS Registry Number: 75-15-0
Synonyms: Carbon Bisulfide; Carbon Bisulphide; Carbon Disulphide; Carbon
Sulfide; Dithiocarbonic Anhydride; NCI-C04591; Sulphocarbonic Anhydride;
Sulphuret of Carbon; Weeviltox
Chemical Formula: CS2
Molecular Weight: 76.13
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 10,000 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 116°F, 46.5°C (*Merck 1983)
Specific Gravity (H2O-1): 1.2632 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 360 at 25°C (*Sunshine 1969)
Melting Point: -167°F, -110.8°C (*Weast 1979)
Vapor Density (AIR-1): 2.67 (*Merck 1983)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.294% at 20°C (*Merck 1983)
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CAS Registry Number: 75-15-0
Page 2 of 4
CARBON DISULFIDE
SECTION II (continued)
Appearance and Odor: Mobile clear or faintly yellow liquid; reagent and
commercial grades are foul smelling. Pure distillates have sweet, pleasing
ethereal odor (*Merck 1983)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 20 ppm; Ceiling Concentration 30 ppm; Peak
Concentration 100 ppm/30 minutes/8 hours (*NIOSH 1985)
ACGIH TLV: 30 mg/ms (lOppm) (skin) (*ACGIH 1980)
IDLH: 500 ppm (NIOSH/OSHA 1978, p. 60)
Other Limits Recommended: NIOSH: 10 hour TWA 1 ppm; Ceiling Concentration
10 ppm/15 minutes (NIOSH 1987 p.72); EEGL 50.0 ppm (60 minutes) (NRC 1984a,
pp. 41-56)
Routes of Entry: Inhalation: Yes (*NIOSH/RTECS 1985)
Skin: Yes (*Gosselin 1976)
Ingestion: Yes (*NIOSH/RTECS 1985)
Health Hazards (Acute, Delayed, and Chronic): The material affects the
central nervous system, cardiovascular system, eyes, kidneys, liver, and
skin. It may be absorbed through the skin as a vapor or liquid, inhaled or
ingested. The probable oral lethal dose for a human is between 0.5 and 5
g/kg or between 1 ounce and 1 pint (or 1 pound) for a 70 kg (150 Ib.)
person (*Gosselin 1976). In chronic exposures, the central nervous system
is damaged and results in the disturbance of vision and sensory changes as
the most common early symptoms (Sax 1984, p. 641). Lowest lethal dose for
humans has been reported at 14 mg/kg or 0.98 grams for a 70 kg person
(*NIOSH/RTECS 1985).
Medical Conditions Generally Aggravated by Exposure: Alcoholics and those
suffering from neuropsychic trouble are at special risk (*LeFaux 1968).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -22°F, -30°C (CC) (Merck 1983, p. 251)
Flammable Limits:
LEL: 1.3% (*Merck 1983); 1% (*Sunshine 1969)
UEL: 50% (*Merck 1983); 44% (*Sunshine 1969)
Extinguishing Methods: Use dry chemical, carbon dioxide or other inert
gas. Cooling and blanketing with water spray is effective in case of fires
in metal containers or tanks to help prevent reignition by hot surfaces.
Foam is ineffective (NFPA 1984, p. 49-27).
Special Fire Fighting Procedures: If the vapor concentration exceeds 2
percent by volume or is unknown, self-contained breathing mask with.full
face should be used by all persons entering contaminated area ("CHRIS
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CAS Registry Number: 75-15-0
Page 3 of 4
CARBON BISULFIDE
SECTION IV (continued)
1978). Wear special protective clothing. Isolate for 1/2 mile in all
directions if tank car or truck is involved in fire (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: Ignition temperature dangerously low:
212°F, 100°C (Merck 1983, p. 251). Vapors may be ignited by contact with
ordinary light bulb (*NPFA 1978); when heated to decomposition, it emits
highly toxic fumes of oxides of sulfur (*Sax 1979).
NFPA Flammability Rating: 3
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (Merck 1983, p. 251)
Stable:
Conditions to Avoid: Decomposes on standing for a long time (Merck
1983, p. 251)
Incompatibility (Materials to Avoid): Air, rust, halogens, metal azides,
metals, oxidants; when exposed to heat or flame reacts violently with
aluminum, chlorine, azides, hypochlorite, ethylamine diamine, ethylene
imine, fluorine, metallic azides of lithium, potassium, cesium, rubidium
and sodium, nitrogen oxides, potassium, zinc and (sulfuric acid plus
permanganate) (Sax 1984, p. 641).
Hazardous Decomposition or Byproducts: When heated to decomposition,
emits highly toxic fumes of sulfur oxides and can react vigorously with
oxidizing materials (Sax 1984, p. 642).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Carbon disulfide is used in the manufacture of soil disinfectants and
vacuum tubes and is used as a solvent for cleaning and extractions,
especially in metal treatment and plating. It is a fumigant for
commodities, a corrosion inhibitor, and a polymerization inhibitor for
vinyl chloride (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of a spill: (1) remove all ignition sources, (2) ventilate area of
spill or leak, and (3) for small quantities, absorb on paper towels.
Evaporate the spills in a safe place, such as a fume hood. Large
quantities can be reclaimed or collected and atomized in a suitable
combustion chamber equipped with an appropriate effluent gas-cleaning
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CAS Registry Number: 75-15-0
Page 4 of 4
CARBON DISULFIDE
SECTION VII (continued)
device (*NIOSH/OSHA 1981). If carbon disulfide is spilled in water,
neutralize with agricultural lime, crushed limestone, or sodium
bicarbonate. If dissolved, apply activated carbon at ten times the spilled
amount. Use mechanical dredges or lifts to remove immobilized masses of
pollutants and precipitates (Student 1981, p. 106). Do not touch spilled
material; stop leak if you can do it without risk. Use water spray to
reduce vapors (DOT 1984, Guide 28).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/MANY
CPE POOR/MANY
Neoprene POOR/LIMITED*
Nitrile POOR/MANY
PE POOR/MANY
PVC POOR/LIMITED*
Teflon POOR/LIMITED
Viton EXCELLENT/MANY
Viton/Chlorobutyl POOR/MANY
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 75-15-0
Page 1 of 3
Emergency First Aid Treatment Guide
for
CARBON BISULFIDE
(75-15-0)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Clear, colorless, or faintly yellow, mobile liquid.
Odor - Slight, sweetly pleasant, ethereal (commercial form is foul smelling).
Commercial Form - Azeotrope with water containing 97.2% carbon disulfide in
drums or tank cars.
Uses - Solvent, chemical intermediate; polymerization inhibitor; corrosion
inhibitor; agent in metal treatment; anthelmintic; fumigant; manufacture of
soil disinfectants, vacuum tubes, and flotation devices.
Caution: Flammable liquid. Avoid sources of extreme heat or ignition
including sparks or fire.
Other Names - Carbon bisulfide, carbon sulfide, dithiocarbonic anhydride,
sulphocarbonic anhydride, Weeviltox.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, alcohol, water, milk, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
diazepam, phenytoin, phenobarbitol, Vitamin B6, urea.
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EFATG
CAS Registry Number: 75-15-0
Page 2 of 3
, CARBON DISULFIDE
Signs and Symptoms of Acute Carbon Disulfide Exposure:
Warning: Effects may be delayed. Caution is advised.
Acute exposure to carbon disulfide primarily affects the central nervous
system producing signs and symptoms that may include headache, dizziness,
difficulty swallowing, nervousness, tremors, mental depression, delirium,
psychosis, convulsions, paralysis, and coma. Nausea, vomiting, cyanosis (blue
tint to skin and mucous membranes), hypothermia (low body temperature), and
peripheral vascular collapse may also occur.
Respiratory effects include coughing, dyspnea (shortness of breath), and
respiratory failure. Carbon disulfide is a strong skin irritant; dermal
exposure may result in severe burns. Eye exposure may cause degeneration of
the retina and optic nerve. Pupils may be dilated.
Emergency Life-Support Procedures:
Acute exposure to carbon disulfide may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to carbon disulfide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to carbon disulfide.
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EFATG
' CAS Registry Number: 75-15-0
Page 3 of 3
t
CARBON DISULFIDE
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least IS minutes.
5. Wash exposed skin areas three times. Wash initially with soap and water
follow with an alcohol wash, then wash again with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Give the victims water or milk: Children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 75-18-3
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - DIMETHYL SULFIDE
CAS Registry Number: 75-18-3
Synonyms: 2-Thiapropane; 2-Thiopropane; Dimethyl Monosulfide; Dimethyl
Sulphide; Dimethyl Thioether; DMS, Exact-S; Methane, Thiobis-;
Methanethiomethane; Methyl Monosulfide; Methyl Sulphide; Methylthiomethane;
Thiobismethane
Chemical Formula: C2H6S
Molecular Weight: 62.13
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(mouse) 0.031 mg/liter (*NIOSH/RTECS 1985)
TPQ: 100 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 99.7°F, 37.3°C (*Weast 1979)
Specific Gravity (H2O»1): 0.8483 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 400 mmHg at 18.7°C (Perry, 1984, p. 3-55)
Melting Point: -144.9°F, -98.27°C (*Weast 1979)
Vapor Density (AIR=1): 2.14 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Weast 1979)
Appearance and Odor: Colorless liquid with an unpleasant, wild radish,
cabbage-like odor (*Fenaroli 1975).
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CAS Registry Number: 75-18-3
Page 2 of 3
DIMETHYL SULFIDE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Clayton and Clayton 1981-82)
Skin: Yes (*Clayton and Clayton 1981-82)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Dimethyl sulfide causes
softening and irritation of the skin. Orally it is an irritant (*Sax
1975). It is a moderate eye irritant (*Clayton and Clayton 1981-82). It
is an eye, nose, throat and skin irritant (*CHRIS 1978).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -55°F (*Clayton and Clayton 1981-82)
Flammable Limits:
LEL: 2.2% (*Sax 1979)
UEL: 19.7% (*Sax 1979)
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog or foam (*DOT 1984).
Special Fire Fighting Procedures: Wear self-contained breathing apparatus
and full protective clothing. Move container from fire area. Cool
containers that are exposed to flames with water from the side until well
after the fire is out. For massive fire in cargo area, used unmanned hose
holder or monitor nozzles; if this is impossible withdraw from area and let
fire burn. Withdraw immediately in case of rising sound from venting
safety device or any discoloration of tank due to fire. Isolate for 1/2
mile in all directions if tank car or truck is involved in fire (*DOT
1984).
Unusual Fire and Explosion Hazards: Flammable/combustible material, may
be ignited by heat, sparks or flames. Vapors may travel to a source of
ignition and flash back. Container may explode in heat of fire. Vapor
explosion hazard indoors, outdoors or in sewers (*DOT 1984).
NFPA Flammability Rating: 4
SECTION V ~ REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
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CAS Registry Number: 75-18-3
Page 3 of 3
DIMETHYL SULFIDE
SECTION V (continued)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Reacts vigorously with oxidizing
materials (*Sax 1979). Incompatible with dibenzoyl peroxide (Sax 1984, p.
1201).
Hazardous Decomposition or Byproducts: Combustion products include toxic
and irritating fumes of sulfur dioxide (Weiss 1980, p. 367).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 367)
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
It is a gas odorant, catalyst impregn'ator, solvent for anhydrous mineral
salts, flavoring ingredient in foods and beverages, chemical intermediate
for solvents and dimethyl sulfoxide (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind. Shut off ignition sources; no flares, smoking or flames in
hazard area. Stop leak. Use water spray to reduce vapors. Take up spills
with noncombustible absorbent material (*DOT 1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush eyes with running water for at least 15 minutes. Wash
skin with soap and water. Remove and isolate contaminated clothing and
shoes at the site (*DOT 1984).
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CAS Registry Number: 75-21-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - ETHYLENE OXIDE
CAS Registry Number: 75-21-8
Synonyms: alpha, beta-Oxidoethane; Anprolene; Dihydrooxirene; Dimethylene
Oxide; E O; ETO; NCI-C50088; Oxacyclopropane; Oxane; Oxidoethane;
1,2-Epoxyethane; Oxiran; Oxirane; Oxirene, Dihydro-; Oxyfume; Oxyfume 12; T-Gas
Chemical Formula: C2H4O
Molecular Weight: 44.06
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 1,000 (pounds)
RQ: 1 (pounds) (statutory); 10 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Gas
Boiling Point: 51.3°F, 10.7°C (*Sunshine 1969)
Specific Gravity (H2O=1): 0.8222 at 10°C/10°C (*Sunshine 1969)
Vapor Pressure (mmHg): 1095 at 20°C (NIOSH/OSHA 1978, p. 100)
Melting Point: -170.5°F.-112.5°C (*Sunshine 1969) '
Vapor Density (AIR=1): 1.49 (*Environment Canada 1982)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Merck 1976)
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CAS Registry Number: 75-21-8
Page 2 of 4
ETHYLENE OXIDE
SECTION II (continued)
Appearance and Odor: Colorless gas at room temperature but a mobile
liquid below 12°C (54°F) and has a sweet odor (*Merck 1976; "CHRIS 1978)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 1 ppm (NIOSH 1987, p. 122)
ACGIH TLV: 2 mg/m3 (1 ppm) (*ACGIH 1984)
IDLH: 800 ppm (*NIOSH/OSHA 1981)
Other Limits Recommended: NIOSH: <0.1 ppm, 8 hour TWA; 5 ppm, 10 minute
ceiling (NIOSH 1987 p. 122). Industrial substance suspect of carcinogenic
potential for humans - recommended TLV 1 ppm (ACGIH 1984, p. 42).
EEGL 20.0 ppm (60 minutes) (NRC 1986, pp. 35-68).
Routes of Entry: Inhalation: Yes (*Gilman 1980)
Skin: Yes (Sax 1984, p. 1348)
Ingestion: Yes (Sax 1984, p. 1348)
Health Hazards (Acute, Delayed, and Chronic): It can cause death. Lowest
inhalation concentration causing toxic effects is 12500 ppm/10 seconds
(*NIOSH/RTECS 1985). It is a strong skin irritant (*CHRIS 1978). Neuro-
logical disorders and even death have been reported (*Gilman 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Greater than -18°C (*Sunshine 1969); but less
than 0°F (OC) (*CHRIS 1978)
Flammable Limits:
LEL: 3.0% (*Sax 1975)
UEL: 100% (*Sax 1975)
Extinguishing Methods: Extinguish with alcohol foam, carbon dioxide, dry
chemical or water spray, fog, or foam. Let burn unless leak can be stopped
immediately (*DOT 1984).
Special Fire Fighting Procedures: Move container from fire area if you
can do so without risk. Stay away from ends of tanks. Fight fire from
maximum distance. For massive fire in-cargo area, use unmanned hose holder
or monitor nozzles; if this is impossible, withdraw from area and let fire
burn. Withdraw immediately in case of rising sound from venting safety
device or any discoloration of tank due to fire. Isolate for 1 mile in all
directions if tank car or truck is involved in fire. Keep unnecessary
people away; isolate hazard area and deny entry. Stay upwind; keep out of
low areas. Wear positive pressure breathing apparatus and full protective
clothing. Evacuate area endangered by gas (*DOT 1984).
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CAS Registry Number: 75-21-8
Page 3 of 4
ETHYLENE OXIDE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Severe explosion hazard when exposed
to heat or flame (Sax 1984, p. 1348). Irritating vapors are generated when
heated. Vapor is heavier than air and may travel considerable distance to
a source of ignition and flash back (*CHRIS 1978). Vapor forms explosive
mixtures with air over a wide range (*NFPA 1978). Liquid is not detonable
but the vapor may be readily initiated into explosive decomposition
(*Bretherick 1979).
NFPA Flammability Rating: 4
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Air, heat, acids and bases (Sax 1984,
p. 1348); metal or metal chloride catalysts (*NFPA 1978)
Incompatibility (Materials to Avoid): Metal fittings containing copper,
silver, mercury or magnesium; ammonia (*Bretherick 1979);
oxidizing agents; acids, organic bases; amines; certain salts; alcohols;
mercaptans (*General Electric Co. 1980, MSDS #433); ferric chloride;
magnesium perchlorate; m-nitroaniline; trimethylamine (*ITI 1982);
potassium, tin chlorides; alkanethiols; bromoethane; aluminum
chloride; aluminum oxide; iron chlorides; and iron oxides (Sax 1984, p.
1348).
Hazardous Decomposition or Byproducts: Decomposition products are
explosive (*ITI 1982).
Hazardous Polymerization: May Occur: Yes (*Sax 1975)
May Not Occur:
Conditions to Avoid: Acids; covalent halides such as chlorides of
aluminum, iron (III), tin (IV); basic materials like alkali hydrides,
ammonia, amines, and potassium; catalytically active solids such as
aluminum or iron oxides or rust (*Bretherick 1975); chlorides of boron,
aluminum, tin, and iron; some carbonates; and metals such as copper and
copper alloys (*Patty 1963)
SECTION VI - USE INFORMATION
Ethylene oxide is a chemical intermediate for ethylene glycol, nonionic
surfactants, glycol ethers, ethanolamines, triethylene glycol, and
polyethylene glycol (*SRI). Used as a fumigant for foodstuffs and
textiles, for sterilizing surgical instruments, and as an agricultural
fungicide (Merck 1983, p. 550). Registered as a pesticide in the U.S.
(USEPA/Active Ingredients 1985).
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CAS Registry Number: 75-21-8
Page 4 of 4
ETHYLENE OXIDE
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section III above). Shut off
ignition sources; do not allow flares, smoking or flames in the hazard area.
Stop leak if you can do so without risk. Use water spray to reduce
vapors; do not get water inside container. For small spills flush area
with flooding amounts of water. For large spills dike spill for later
disposal. (*DOT 1984).
SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED*
CPE GOOD/LIMITED*
Neoprene POOR/LIMITED*
Nitrile POOR/MANY
PVC POOR/LIMITED*
Viton POOR/LIMITED*
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 75-21-8
Page 1 of 3
Emergency First Aid Treatment Guide
for
ETHYLENE OXIDE
(75-21-8)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless gas; mobile liquid below 12 degrees C (54 degrees F) or
under pressure.
Odor - Sweet, etherlike.
Commercial Forms - Mixtures with carbon dioxide or fluorocarbon 12.
Uses - Chemical intermediate for ethylene glycol, nonionic surfactants, glycol
ethers, ethanolamines, triethylene glycol, polyethylene glycol; fumigant,
fungicide, ripening agent for fruits; sterilizing surgical instruments.
Materials to Avoid - Acids, alcohols, amines, ammonia, oxidizers, metal
catalysts.
Caution: Explosion potential is high. Avoid all heat sources including fire.
Other Names - Anprolene, dihydrooxirene, 1,2-epoxyethane, oxacyclopropane,
oxane, oxidoethane, oxirane, oxyfume.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal,
saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate.
Signs and Symptoms of Acute Ethylene Oxide Exposure:
Warning: Ethylene oxide is corrosive to moist tissues. Caution is advised.
Signs and symptoms of acute exposure to ethylene oxide may be severe, and
include dyspnea (shortness of breath), cough, pulmonary edema, pneumonia, and
respiratory failure. Lethargy, headache, dizziness, twitching, convulsions,
paralysis, and coma may be observed. Cardiac arrhythmias and cardiovascular
collapse may also occur.
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EFATG
CAS Registry Number: 75-21-8
Page 2 of 3
ETHYLENE OXIDE
Gastrointestinal effects of acute exposure may include nausea, vomiting, and
abdominal pain. Ethylene oxide may severely irritate or burn mucous membranes
and moist skin. Eye contact may result in conjunctivitis (red, inflamed eyes)
and erosion of the cornea.
Emergency Life-Support Procedures:
Acute exposure to ethylene oxide may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to ethylene oxide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to ethylene oxide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be IMMEDIATELY flushed with
lukewarm water for AT LEAST 15 minutes.
5. If liquid is spilled on the skin, allow ethylene oxide to vaporize before
washing THOROUGHLY with soap and water.
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EFATG
CAS Registry Number: 75-21-8
Page 3 of 3
ETHYLENE OXIDE
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Give the victims water or milk: children up 1 year old, 125 mL (4 oz or
1/2 cup); children 1 to 12 years old 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Ethylene oxide generally acts as its own cathartic; however, if deemed
necessary, excretion may be promoted by administering a saline cathartic
or sorbitol to conscious and alert victims. Children require 15 to 30 g
(1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is
recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 75-44-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - PHOSGENE
CAS Registry Number: 75-44-5
Synonyms: Carbon Oxychloride; Carbonyl Chloride; CG; Chloroformyl Chloride;
NCI-C60219; Carbon Bichloride Oxide; Carbonic Acid Dichloride; Carbonic
Bichloride; Carbonyl Bichloride; Phosgen
Chemical Formula: CC12O
Molecular Weight: 98.92
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 10 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Gas
Boiling Point: 47°F, 8.2°C (*Merck 1976)
Specific Gravity (H2O=»1): 1.432 at 0°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 1215 at 20°C (*Merck 1976)
Melting Point: -180°F, -118°C (*Merck 1976)
Vapor Density (AIR=1): 3.4 (*NFPA 1975)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (*Merck 1976)
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CAS Registry Number: 75-44-5
Page 2 of 4
PHOSGENE
SECTION II (continued)
Appearance and Odor: Colorless gas; colorless, fuming liquid; suffocating
odor reminiscent of moldy hay (*Merck 1976). In dilute concentration has
odor of green corn (*Arena 1974); odor similar to decaying fruit at room
temperature (*Encyc Occupat Health and Safety 1971).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.4 mg/ms (0.1 ppm) (NIOSH 1987, p. 192).
ACGIH TLV: TWA 0.4 mg/m3 (0.1 ppm) (ACGIH 1986-87, p. 27).
IDLH: 2 ppm (NIOSH 1987, p. 192) \
Other Limits Recommended: NIOSH: 0.1 ppm (10 hour TWA); Ceiling 0.2 ppm for
15 minutes (NIOSH 1987, p. 192). EEGL 0.2 ppm (60 minutes) (NRC 1984b, pp.
69-86).
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*DOT 1984)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Phosgene is a lung toxicant
that causes damage to the capillaries, bronchioles and. alveoli of the lungs
(U.S. Army 1975, p. 3-1) by decomposition to hydrochloric acid. There is
little immediate irritant effect upon the respiratory tract, and the
warning properties of the gas are therefore very slight. Pulmonary edema,
bronchopneumonia and occasionally lung abscesses develop. Degenerative
changes in the nerves have been reported as later developments. A
concentration of 25 ppm is dangerous for exposures lasting 30-60 minutes
and 50 ppm is rapidly fatal after even short exposure (Sax 1984, p. 2210).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Nonflammable (NFPA 1984, p. 49-73). For small
fires, use dry chemical or carbon dioxide. Use water spray, fog, or foam
for larger fires. Do not get water inside containers. Move container from
fire area if you can do so without risk. Stay away from the ends of tanks,
and cool exposed containers with water until well after the fire is out.
Isolate the area until gas has dispersed (*DOT 1984).
Special Fire Fighting Procedures: If necessary to stop flow of gas, use
water spray to protect the personnel effecting shutoff. Sodium hydroxide
or anhydrous ammonia have been used to neutralize phosgene (*NFPA 1975).
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CAS Registry Number: 75-44-5
Page 3 of 4
PHOSGENE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: When heated to decomposition or on
contact with water or steam, it will react to produce toxic and corrosive
fumes (*Sax 1975).
NFPA Flammability Rating: 0
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes, in steel containers if dry (U.S. Army 1975,
P. 3-1)
Conditions to Avoid: Moisture (*Sax 1975)
Incompatibility (Materials to Avoid): Reacts violently with aluminum;
tert-butyl azido formate; 2,4-hexadiyn-l,6-diol; isopropyl alcohol;
potassium; sodium; hexafluoro isopropylidene; amino lithium; lithium (Sax
1984, p. 2211).
Hazardous Decomposition or Byproducts: When heated to decomposition or on
contact with water or steam, it will react to produce toxic and corrosive
fumes (*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Delayed-action military chemical agent (U.S. Army 1975, p. 3-1). Chemical
intermediate for toluene diisocyanate, methyl isocyanate, acyl chlorides,
diphenylmethane-4,4'-diisocyanate, chloroformate esters, diethyl carbonate,
dimethyl carbamoyl chloride, polymethylene polyphenylisocyanate,
polycarbonate resins (*SRI); aniline dyes (*Hamilton 1974); pesticides,
herbicides, dyes (Hawley 1981, p. 807).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry.
Stay upwind and keep out of low areas. Ventilate closed spaces before
entering.
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
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CAS Registry Number: 75-44-5
Page 4 of 4
PHOSGENE
SECTION VIII (continued)
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 75-44-5
Page 1 of 3
Emergency First Aid Treatment Guide
for
PHOSGENE
(75-44-5)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Easily liquefied colorless gas or colorless to light yellow
liquid.
Odor - Strong and stifling when concentrated, haylike in dilute form.
Commercial Form - 99% pure liquefied gas.
Uses - Organic synthesis; chemical intermediate for isocyanates, acid
chlorides, and polycarbonates; pesticides; herbicides; dye manufacture;
chemical warfare agent.
Materials to Avoid - Active metals, aluminum, alcohol, water (except for use in
emergency life support).
Caution: Hydrochloric acid will be liberated upon contact with water, steam,
or alcohols. A violent reaction will occur following contact with aluminum and
active metals. Phosgene will produce toxic and corrosive fumes when heated to
decomposition; avoid sources of extreme heat.
Other Names - Carbon oxychloride, carbonic acid dichloride, carbonyl chloride,
chloroformyl chloride, diphosgene.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, normal saline, D5W,
Ringer's lactate, dimercaprol.
Signs and Symptoms of Acute Phosgene Exposure:
Warning: Effects may be delayed up to 24 hours. Caution is advised.
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EFATG
CAS Registry Number: 75-44-5
Page 2 of 3
PHOSGENE
Acute exposure to phosgene may result in severe irritation and burns of the
skin, eyes, mucous membranes, and respiratory passages. Cough, dyspnea
(shortness of breath), pain in the chest, and severe pulmonary edema may also
occur. Cyanosis (blue tint to the skin and mucous membranes) and anxiety may
be observed.
Emergency Life-Support Procedures:
Acute exposure to phosgene may require decontamination and life support for the
victims. Emergency personnel should wear protective clothing appropriate to
the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to phosgene.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to phosgene.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
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EFATG
CAS Registry Number: 75-44-5
Page 3 of 3
PHOSGENE
7. RUSH to a health care facility.
Ingestion Exposure: No information is available.
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CAS Registry Number: 75-55-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - PROPYLENEIMINE
CAS Registry Number: 75-55-8
Synonyms: Aziridine, 2-Methyl-; 2-Methylazacyclopropane; 2-Methylaziridine;
2-Methylethylenimine; Methylethylenimine; Propylenimine; Propylene Imine
Chemical Formula: C3H7N
Molecular Weight: 57.11
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (rat)
19 mg/kg (*NIOSH/RTECS 1985)
TPQ: 10,000 (pounds)
RQ: 1 (pounds) (statutory)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 151-153°F, 66-67°C (*Encyc Occupat Health and Safety 1983)
Specific Gravity (H2O»1): 0.8039-0.8070 at 25°C/25°C (Hawley 1981, p.
865)
Vapor Pressure (mmHg): 112 at 20°C (*IARC 1972-1985)
Melting Point: -85°F, -65°C (*IARC 1972-1985)
Vapor Density (AIR-1): 2.0 (*Encyc Occupat Health and Safety 1983)
Evaporation Rate (Butyl acetate** 1): Not Found
Solubility in Water: Miscible (*IARC 1972-1985)
Appearance and Odor: Colorless, oily liquid with an odor similar to
aliphatic amines (i.e., fishy) (*IARC 1972-1985)
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CAS Registry Number: 75-55-8
Page 2 of 4
PROPYLENEIMINE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: 5 mg/m3 (2 ppm) (NIOSH 1987, p. 200)
ACGIH TLV: TWA 5 mg/ms (2 ppm) (skin) (ACGIH 1986-1987, p. 28)
IDLH: 500 ppm (NIOSH 1987, p. 200)
Other Limits Recommended: Industrial substance suspect of carcinogenic
potential to man (*ACGIH 1983)
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 865)
Skin: Yes (Hawley 1981, p. 865)
Ingestion: Yes (Hawley 1981, p. 865)
Health Hazards (Acute, Delayed, and Chronic): Toxic after acute exposure.
Can severely irritate eyes, skin, and lungs (*Encyc Occupat Health and
Safety 1983).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 25°F (CC) (*ACGIH 1980)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: If material is on fire, use foam, carbon dioxide,
or dry chemical (Student 1981, p. 433).
Special Fire Fighting Procedures: If material is on fire, do not
extinguish fire unless flow can be stopped. Use water in flooding
quantities as a "fog" and use to cool all affected containers. Keep
material out of water sources and sewers. Build dikes to contain flow as
necessary (Student 1981, p. 433). Isolate for 1/2 mile in all directions
if tank car or truck is involved in fire (DOT 1984, Guide 30).
Unusual Fire and Explosion Hazards: Chemical is extremely flammable;
vapors are heavier than air (Student 1981, pp. 433).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Thermally unstable (Student 1981, p. 433)
Stable:
Conditions to Avoid: Not Found
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CAS Registry Number: 75-55-8
Page 3 of 4
PROPYLENEIMINE
SECTION V (continued)
Incompatibility (Materials to Avoid): Acids, strong oxidizers (NIOSH/
OSHA 1978, p. 160)
Hazardous Decomposition or Byproducts: Toxic oxides of nitrogen are
produced during combustion (Student 1981, p. 433).
Hazardous Polymerization: May Occur: Yes (Student 1981, p. 433)
May Not Occur:
Conditions to Avoid: Contact with acid promotes violent
polymerization (Student 1981, p. 433)
SECTION VI - USE INFORMATION
Propyleneimine is used as a chemical intermediate in the modification of
latex surface coating resins, polymers in textile and paper industries,
dyes, photography, gelatins, oil additives and organic synthesis. It is a
comonomer for polymers with methacrylic acid and esters (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors; avoid bodily contact with the material. Do not
handle broken packages without protective equipment. Wash away any
material which may have contacted the body with copious amounts of water or
soap with water. Use water spray to disperse vapors and dilute standing
pools of liquid. Keep sparks and flames away. Attempt to stop leak if it
can be done without hazard. (Student 1981, p. 433).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
'Signs and Symptoms of Exposure: Inflammation and blistering of the skin,
eye and upper respiratory tract; irritation, nausea, itching, and periodic
vomiting. Headache, dizziness, and pain in the temple. Shortness of
breath, and increased nasal and laryngeal secretion are seen (*Encyc
Occupat Health and Safety 1983).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If victim is not breathing, give artificial
respiration; if breathing is labored, give oxygen. In case of eye/skin
contact, immediately flush with water for at least 15 minutes (DOT 1984,
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CAS Registry Number: 75-55-8
Page 4 of 4
PROPYLENEIMINE
SECTION IX (continued)
Guide 30). Neutralization with acids (e.g., vinegar, fruit juices) is
contraindicated. Avoid vomiting (*Rumack 1975 to Present).
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CAS Registry Number: 75-56-9
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - PROPYLENE OXIDE
CAS Registry Number: 75-56-9
Synonyms: 1,2-Epoxypropane; Epoxypropane; Ethylene Oxide, Methyl-; Methyl
Ethylene Oxide; Methyl Oxirane; Methyloxirane; NCI-C50099; Oxirane, Methyl-;
Propane, 1,2-Epoxy-; Propane, Epoxy; Propene Oxide; Propylene Epoxide;
Propyleneoxide; 1,2-Propylene Oxide
Chemical Formula: C3H6O
Molecular Weight: 58.08
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 10,000 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 93.61°F, 34.23°C (*Merck 1976)
Specific Gravity (H2O=1): 0.859 at 0°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 445 at 20°C (*Sunshine 1969)
Melting Point: -169.83°F, -112.13°C (*Merck 1976)
Vapor Density (AIR=1): 2.0 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 40.5% by weight at 20°C (*Merck 1976)
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CAS Registry Number: 75-56-9
Page 2 of 4
PROPYLENE OXIDE
SECTION II (continued)
Appearance and Odor: Colorless liquid (*Merck 1976) with sweet, alcoholic
odor like natural gas, ether, or benzene (*Clayton and Clayton 1981-82)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 240 mg/m3 (100 ppm) (NIOSH 1987, p. 200)
ACGIH TLV: TWA 50 mg/ms (20 ppm) (*ACGIH 1983)
IDLH: 2000 ppm (NIOSH/OSHA 1978, p. 160)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Clayton and Clayton 1981-82)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): This material is
moderately toxic by inhalation and ingestion. It may cause irreversible
and reversible changes (*Sax 1975). Skin contact with the material or
solutions of the material cause irritation; diluted solutions are more
irritating than undiluted materials (*Encyc Occupat Health and Safety
1971). Exposure may cause mild depression of the central nervous system
and eye, nasal, and lung irritation (*Rumack 1975 to Present). Contact
with the liquid can cause blindness and death. Pulmonary edema may recur
up to 2 weeks after exposure (*Morgan 1982).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV — FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -35°F, -37°C (CC) (*Sunshine 1969)
Flammable Limits:
LEL: 2.8% (*Sax 1979)
UEL: 37% (*Sax 1979)
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide, water
spray, fog or foam (DOT 1984, Guide 26).
Special Fire Fighting Procedures: Firefighting should be done from a
safe distance or from a protected location (*NFPA 1978). Wear self-
contained (positive pressure if available) breathing apparatus and full
protective clothing. Isolate for 1/2 mile in all directions if tank car
or truck is involved in fire. Move container from area if you can do so
without risk. Spray cooling water on containers that are exposed to
flames until well after fire is out. For massive fire in cargo area, use
unmanned hose holder or monitor nozzles; if this is impossible, withdraw
from area and let fire burn. Withdraw immediately in case of rising sound
from venting safety device or any discoloration of tank due to fire (DOT
1984, Guide 26).
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CAS Registry Number: 75-56-9
Page 3 of 4
PROPYLENE OXIDE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Vapor is heavier than air and may
travel considerable distance to source of ignition and flash back. Vapors
form explosive mixture with air. If polymerization takes place in
container, there may be a violent rupture of container (*NFPA 1978).
Explosion hazard is severe when exposed to flame (*Sax 1979).
NFPA Flammability Rating: 4
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 787)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Violently reacts with acetylide-
forming metals such as copper or copper alloys (*Clayton and Clayton
1981-82); ammonium hydroxide; chlorosulfonic acid; hydrochloric acid;
hydrofluoric acid; nitric acid; oleum and sulfuric acid (Sax 1984, p.
1289).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Yes (*Clayton and Clayton
1981-82)
May Not Occur:
Conditions to Avoid: Active catalytic surfaces such as anhydrous
chlorides of iron, tin, and aluminum; peroxides of iron and aluminum;
and alkali metal hydroxides (*NFPA 1987); high temperatures; alkalies;
aqueous acids; amines and acidic alcohols (Weiss 1980, p. 787).
SECTION VI - USE INFORMATION
This material is used primarily as a chemical intermediate for
polyurethane polyols, propylene glycol, and dipropylene glycol (*SRI). It
is also used for sterilization of packaged foods (*Farm Chemicals Handbook
1983), as a herbicide (*Clayton and Clayton 1981-82), in the preparation
of lubricants, surfactants, and oil demulcifiers, and as a fumigant and
soil sterilant (*Merck 1976).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Ventilate area of spill or leak. Do not allow the material to enter
confined space, such as a sewer, because of the possibility of an
explosion (*NIOSH/OSHA 1981). Stop discharge if possible. Stay upwind
and use water spray to knock down vapor. Avoid contact with liquid and
vapor (Weiss 1980, p. 787). Water spray may be used to flush spills
away from exposure and to dilute spills to nonflammable mixture (*NFPA
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CAS Registry Number: 75-56-9
Page 4 of 4
PROPYLENE OXIDE
SECTION VII (continued)
1978). Shut off ignition sources; no flares, smoking, or flames in
hazard area. Stop leak if you can do so without risk. Use water spray
to reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal.
Large spills: dike far ahead of spill for later disposal (DOT 1984,
Guide 26).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED
Butyl/Neoprene POOR/LIMITED*
Neoprcne POOR/LIMITED*
Nitrile POOR/LIMITED*
PE POOR/MANY
PVC POOR/LIMITED*
Teflon GOOD/LIMITED
Viton POOR/MANY
Viton/Neoprene POOR/LIMITED*
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 75-56-9
Page 1 of 3
Emergency First Aid Treatment Guide
for
PROPYLENE OXIDE
(75-56-9)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Colorless liquid or gas above 34 degrees C (94 degrees F).
Odor - Sweet, alcohollike.
Commercial Form - Mixed with carbon dioxide.
Uses - Manufacturer of polyurethane, polyols, propylene glycol, and dipropylene
glycol; fumigant; solvent.
Materials to Avoid - Acids, alkali, oxidizers, metals.
Caution: Flammable liquid. Avoid sources of extreme heat or ignition
including sparks or fire.
Other Names - Epoxypropane, methyl ethylene oxide, methyl oxirane, propene
oxide, propylene epoxide.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline
cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam,
aminophylline, morphine, furosemide, epinephrine, atropine.
Signs and Symptoms of Acute Propylene Oxide Exposure:
Propylene oxide may irritate or burn the skin, eyes, and respiratory tract.
Pulmonary edema may occur up to 2 weeks after exposure. Dermatitis (red,
inflamed skin) is common. Other signs and symptoms of acute exposure may
include headache, nausea, vomiting, and unconsciousness. Victims may appear as
if they are in a drunken stupor.
-------
EFATG
CAS Registry Number: 75-56-9
Page 2 of 3
PROPYLENE OXIDE
Emergency Life-Support Procedures:
Acute exposure to propylene oxide may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to propylene oxide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to propylene oxide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
-------
EFATG
CAS Registry Number: 75-56-9
Page 3 of 3
PROPYLENE OXIDE
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. DO NOT induce vomiting or attempt to neutralize!
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
-------
CAS Registry Number: 75-74-1
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - TETRAMETHYLLEAD
CAS Registry Number: 75-74-1
Synonyms: Lead Tetramethyl; Methylplumbane; TML; Tetramethyl Lead
Chemical Formula: C4H12Pb
Molecular Weight: 267.33
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 100 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): In Lead Compounds category
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 230°F, 110°C at 10 mmHg (*IARC 1972-1985); decomposes
above 212°F, 100°C (*NFPA 1975)
Specific Gravity (H2O=1): 1.995 (*Weast 1976)
Vapor Pressure (mmHg): 22 at 20°C (NIOSH/OSHA 1978, p. 176)
Melting Point: -17.5°F, -27.5°C (*Weast 1976)
Vapor Density (AIR-1): 6.5 (NFPA 1984, p. 325M-87)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*IARC 1972-1985)
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CAS Registry Number: 75-74-1
Page 2 of 3
TETRAMETHYLLEAD
SECTION II (continued)
Appearance and Odor: Colorless liquid (*Encyc Occupat Health and Safety
1971); dyed red, orange or blue with a slight musty odor (NIOSH/OSHA 1978,
p. 176).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.075 mg (Lead)/m3 (OSHA 1984, p. 663)
ACGIH TLV: TWA 0.15 mg (Lead)/m3 (skin) (ACGIH 1986-87, p.30)
IDLH: 40 mg(Lead)/m3 (NIOSH 1987, p. 222)
Other Limits Recommended: Maximum air concentration: 0.15 mg/m3 (skin)
(*Casarett 1975)
Routes of Entry: Inhalation: Yes (*NFPA 1975)
Skin: Yes (*NFPA 1975)
Ingestion: Yes (*NFPA 1975)
Health Hazards (Acute, Delayed, and Chronic): Vapors are very toxic.
Fatal lead poisoning may occur by ingestion, vapor inhalation or skin
absorption (*NFPA 1975). Several cases of acute toxicity, usually in the
form of degenerative brain disease, have been described following
occupational exposure (*IARC 1972-1985).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 38°C (*IARC 1972-1985)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: On fires in which containers are not exposed, use
water spray, dry chemical, foam or carbon dioxide (*NFPA 1975).
Special Fire Fighting Procedures: Use water to keep fire exposed
containers cool. If leak or spill has not ignited, use water spray to
disperse vapors or flush spill (*NFPA 1975). For massive fire in cargo
area, use unmanned hose holder or monitor nozzle; if this is impossible
withdraw from area and let fire burn (*DOT 1984).
Unusual Fire and Explosion Hazards: Thermal decomposition is likely to
take the form of vapors at the surface. Rapid decomposition will cause
container to explode (*NFPA 1975). Dangerous fire hazard when exposed to
heat, flame, or oxidizers (Sax 1984, p. 2546).
NFPA Flammability Rating: 3
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CAS Registry Number: 75-74-1
Page 3 of 3
TETRAMETHYLLEAD
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 865)
Conditions to Avoid: Fire, heat, physical damage, and strong
oxidizers (*NFPA 1975). Starts to decompose at about 212°F (100°C).
If confined, may explode or detonate at high temperatures (Weiss 1980,
p. 865).
Incompatibility (Materials to Avoid): Strong oxidizers such as sulfuryl
chloride or potassium permanganate (NIOSH/OSHA 1978, p. 176).
Hazardous Decomposition or Byproducts: Toxic gases are generated in fire
(Weiss 1980, p. 865).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 865)
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Antiknock additive for gasolines; component of mixed alkyl leads for
gasoline additives (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do it without risk.
Use water spray to reduce vapors. Small spills: take up with sand or
other non-combustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(*DOT 1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 75-74-1
Page 1 of 3
Emergency First Aid Treatment Guide
for
TETRAMETHYLLEAD
(75-74-1)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless liquid.
Odor - Musty or fruity.
Commercial Form - Red, orange, or blue liquid.
Use - Gasoline additive.
Materials to Avoid - Oxidizers.
Caution: Flammable liquid. Avoid sources of extreme heat or ignition
including sparks or fire. When burned, toxic fumes of lead oxide will be
emitted.
Other Names - Tetramethylplumbane, TML.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal,
saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam,
phenytoin, phenobarbitol, mannitol, dexamethasone.
Signs and Symptoms of Acute Tetramethyllead Exposure:
Warning: Effects may be delayed for hours to days. Caution is advised.
Signs and symptoms of acute exposure to tetramethyllead may be severe and
include anxiety, irritability, headache, insomnia, disorientation,
violent/frightening dreams, hyperexcitability, delusions, and hallucinations.
Muscular weakness, tremor, incoordination, convulsions, cerebral edema, and
coma may occur. A metallic taste may be noted. Sneezing, bronchitis, and
pneumonia may be noted. Bradycardia (slow heart rate), hypotension (low blood
-------
EFATG
CAS Registry Number: 75-74-1
Page 2 of 3
TETRAMETHYLLEAD-
pressure), hypothermia, and pallor may also occur. Gastrointestinal symptoms
include vomiting and diarrhea. Tetramethyllead may irritate moist skin, eyes,
and mucous membranes.
Emergency Life-Support Procedures:
Acute exposure to tetramethyllead may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to tetramethyllead.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to tetramethyllead.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
-------
EFATG
CAS Registry Number: 75-74-1
Page 3 of 3
TETRAMETHYLLEAD
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Give the victims water or milk: Children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims
are conscious and alert.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50. to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. RUSH to a health care facility.
-------
CAS Registry Number: 75-77-4
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - TRIMETHYLCHLOROSILANE
CAS Registry Number: 75-77-4
Synonyms: Chlorotrimethylsilane; Monochlorotrimethylsilicon; Silane,
Chlorotrimethyl-; Silane, Trimethylchloro-; Silicane, Chlorotrimethyl;
Silylium, Trimethyl-, Chloride; Trimethyl Chlorosilane; Trimethylsilyl Chloride
Chemical Formula: C3H9ClSi
Molecular Weight: 108.66
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LCiow inhalation
(mouse) 0.5 mg/liter/10 minute (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 135°F, 57°C (*Hawley 1977)
Specific Gravity (H2O-1): 0.854 at 25°C (*Hawley 1977)
Vapor Pressure (mmHg): Not Found
Melting Point: -72°F, -57.7°C (*Weast 1984)
Vapor Density (AIR=1): 3.7 (*CHRIS 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Decomposes in water (*Hawley 1977)
Appearance and Odor: Colorless liquid (*Hawley 1977), with a sharp
hydrochloric acid-like odor (*CHRIS 1978).
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CAS Registry Number: 75-77-4
Page 2 of 3
TRIMETHYLCHLOROSILANE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Hawley 1977; *Rumack 1975 to Present)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Similar to other silanes.
Toxicity is rated high for inhalation, ingestion and local irritation. May
cause death or permanent injury after a very short exposure to small
quantities (*Sax 1975).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -18°F (*Hawley 1977); 0°F (OC) (*CHRIS 1978)
Flammable Limits:
LEL: 1.8% (*CHRIS 1978)
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemicals or carbon dioxide.
Do not use water or foam. Cool exposed containers with water (*CHRIS
1978). Water spray, fog, or foam may be required to fight large fires.
However, trimethylchlorosilane may react violently with water. Do not get
water inside containers (*DOT 1984).
Special Fire Fighting Procedures: Use acid-vapor-type respirator, rubber
gloves, chemical worker's goggles, and other protective equipment as
necessary to protect skin and eyes ("CHRIS 1978).
Unusual Fire and Explosion Hazards: Violent reaction with water (Sax
1984, p. 2665). Toxic and irritating hydrogen chloride and phosgene may be
formed in fires. Difficult to extinguish, re-ignition may occur.
Flashback along vapor trail may occur. Containers may explode in fire.
Vapor may explode if ignited in enclosed area (CHRIS 1987).
NFPA Flammability Rating: 3
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 895, *CHRIS 1978)
Conditions to Avoid: Avoid contact with water; it readily hydrolyzes,
liberating hydrochloric acid ("Hawley 1977).
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CAS Registry Number: 75-77-4
Page 3 of 3
TRIMETHYLCHLOROSILANE
SECTION V (continued)
Incompatibility (Materials to Avoid): Reacts with surface moisture,
releasing hydrogen chloride, which will corrode common metals and form
flammable hydrogen gas ("CHRIS 1978).
Hazardous Decomposition or Byproducts: When heated to decomposition or on
contact with acids or acid fumes, chloride fumes are emitted (*Sax 1979).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 895)
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Chemical intermediate for silicone fluids, silylating agent, and a component
of a catalyst for propylene oxide (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section III above). In case of spill or leak,
shut off ignition sources; no flares, smoking or flames in hazard area. Do
not touch spilled material. Stop leak if you can do it without risk. Do
not get water inside container. For small spills, take up with sand or
other non-combustible absorbent material and place into container for later
disposal. For large spills, dike far ahead of spill for later disposal
(*DOT 1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number 75-77-4
Page 1 of 3
Emergency First Aid Treatment Guide
for
TRIMETHYLCHLOROSILANE
(75-77-4)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless liquid.
Odor - Sharp, acrid.
Commercial Form - 98% pure liquid.
Uses - Catalyst, solvent, silylating agent, manufacture of silicone fluids.
Material to Avoid - Water (except for use in emergency life support).
Caution: Highly flammable. Avoid sources of extreme heat or ignition
including sparks or fire.
Other Names - Chlorotrimethylsilane, trimethylsilyl chloride.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W,
Ringer's lactate.
Signs and Symptoms of Acute Trimethylchlorosilane Exposure:
Warning: In the presence of water, trimethylchlorosilane liberates
hydrochloric acid, which is extremely corrosive. Caution is advised.
Signs and symptoms of acute trimethylchlorosilane exposure may include
increased salivation, intense thirst, difficulty swallowing, chills, pain, and
shock. Oral, esophageal, and stomach burns are common. Vomitus generally has
a coffee-ground appearance.
-------
EFATG
CAS Registry Number: 75-77-4
Page 2 of 3
TRIMETHYLCHLOROSILANE
Acute inhalation exposure may result in hoarseness, laryngitis, a feeling of
suffocation, dyspnea (shortness of breath), choking, respiratory tract
irritation, chest pain, and pulmonary edema. The potential for circulatory
collapse is high following ingestion of trimethylchlorosilane. Sneezing,
bleeding of the nose and gums, and ulceration of the nasal and oral mucosa may
also occur. Renal toxicity has been observed in animals.
If the eyes come in contact with trimethylchlorosilane, irritation, pain,
swelling, corneal erosion, and blindness may result. Dermal exposure is
generally followed by dermatitis (red, inflamed skin), severe burns, pain, and
shock.
Emergency Life-Support Procedures:
Acute exposure to trimethylchlorosilane may require decontamination and life
support for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to trimethylchlorosilane.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to trimethylchlorosilane.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
-------
EFATG
CAS Registry Number: 75-77-4
Page 3 of 3
TRIMETHYLCHLOROSILANE
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Rinse mouth with large amounts of water. Inform victims not to swallow
this water.
3. DO NOT induce vomiting or attempt to neutralize!
4 Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
5. Activated charcoal is of no value.
6. Give the victims water or milk: Children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
7. RUSH to a health care facility.
-------
CAS Registry Number: 75-78-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - DIMETHYLDICHLOROSILANE
CAS Registry Number: 75-78-5
Synonyms: Dichlorodimethylsilane; Dichlorodimethylsilicon; Inerton AW-DMCS;
Silane, Dichlorodimethyl-
Chemical Formula: C2H6Cl2Si
Molecular Weight: 129.07
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation:
(mouse) 0.0003 mg/liter/2 hour (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 158°F, 70°C (NFPA 1984, p. 325M-42)
Specific Gravity (H2O=1): 1.1 (NFPA 1984, p. 325M-42)
Vapor Pressure (mmHg): 100 at 17.5°C (Weast 1984, p. D-200)
Melting Point: -123°F, -86°C (*CHRIS 1978)
Vapor Density (AIR=1): 4.45 (NFPA 1984, p. 352M-42)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Decomposes (NFPA 1984, p. 325M-42)
Appearance and Odor: Colorless liquid with sharp irritating odor (*CHRIS
1978).
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CAS Registry Number: 75-78-5
Page 2 of 4
DIMETHYLDICHLOROSILANE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*CHRIS 1978)
Skin: Yes (*CHRIS 1978)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Inhalation irritates mucous
membranes. Severe gastrointestinal damage may occur. Vapors cause severe
eye and lung injury. Upon short contact, second and third degree burns may
occur (*CHRIS 1978).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 16°F (OC) (*Hawley 1977)
Flammable Limits:
LEL: 3.4% (*Sax 1975)
UEL: 9.5% (*Sax 1975)
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam. Move container from fire area if it can be done
without risk. Do not get water inside container. Cool containers that are
exposed to fire from outside until well after fire is out. Withdraw
immediately in case of rising sound from venting safety device or
discoloration of tank due to fire (DOT 1984, Guide 29).
Special Fire Fighting Procedures: Avoid contact with skin, eyes, or
clothing. Wear acid-vapor respirator, rubber gloves, chemical worker's
goggles, other protective and corrosive-resistant equipment as needed
(*CHRIS 1978; *Encyc Occupat Health and Safety 1971). Runoff from fire
control or dilution water may cause pollution. Isolate for one-half mile
in all directions if tank car or truck involved in fire (DOT 1984, Guide
29).
Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an
enclosed area; reacts with water to produce irritating and toxic gases.
Toxic and irritating hydrogen chloride and phosgene may form in fire
(CHRIS 1987). Runoff to sewer may create fire or explosion hazard (DOT
1984, Guide 29).
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980)
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CAS Registry Number: 75-78-5
Page 3 of 4
DIMETHYLDICHLOROSILANE
SECTION V - REACTIVITY DATA (continued)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Reacts vigorously with water to
generate hydrogen chloride ("CHRIS 1978).
Hazardous Decomposition or Byproducts: Reacts with water; irritating gas
is produced. Hydrogen chloride and phosgene gases may be formed upon
heating (CHRIS 1987).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Chemical intermediate for silicone fluids and in ethchlorvynol assays
(*SRI; *AOAC 1965).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section III above). Shut off
ignition sources; no flares, smoking or flames in hazard area. Do not
touch spilled materials; stop leak if you can do so without risk. Use
water spray to reduce vapors; however do not get water inside containers.
Small spills: absorb with sand or other non-combustible absorbent material
and place into containers for later disposal. Large spills: dike far
ahead of spill for later disposal (DOT 1984, Guide 29). Use effective fume
removal device (*AOAC 1965).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Neoprene GOOD/LIMITED**
Nitrile POOR/LIMITED**
PVC POOR/LIMITED**
Viton GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
-------
CAS Registry Number: 75-78-5
Page 4 of 4
DIMETHYLDICHLOROSILANE
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 75-78-5
Page 1 of 3
Emergency First Aid Treatment Guide
for
DIMETHYLDICHLOROSILANE
(75-78-5)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless liquid.
Odor - Sharp, irritating.
Commercial Form - Liquid in steel drums.
Use - Manufacture of silicone products.
Material to Avoid - Water (except for use in emergency life support).
Caution: Flammable liquid. Avoid sources of extreme heat or ignition
including sparks or fire. Dimethylchlorosilane will liberate hydrochloric acid
upon contact with water.
Other Names - Dichlorodimethylsilane, dichlorodimethylsilicon, Inerton AW-DMCS.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W,
Ringer's lactate.
Signs and Symptoms of Acute Dimethyldichlorosilane Exposure:
Signs and symptoms of acute ingestion of dimethyldichlorosilane may be severe
and include increased salivation, intense thirst, difficulty swallowing,
chills, pain, and shock. Oral, esophageal, and stomach burns are common.
Vomitus generally has a coffee-ground appearance. The potential for
circulatory collapse is high following ingestion of dimethyldichlorosilane.
-------
EFATG
CAS Registry Number: 75-78-5
Page 2 of 3
DIMETHYLDICHL.OROSILANE
Acute inhalation exposure may result in sneezing, choking, laryngitis, dyspnea
(shortness of breath), respiratory tract irritation, and chest pain. Bleeding
of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema,
chronic bronchitis, and pneumonia may also occur.
If the eyes have come in contact with dimethyldichlorosilane, irritation,
pain, swelling, corneal erosion, and blindness may result Dermatitis (red,
inflamed skin), severe bu.rns, pain, and shock generally follow dermal exposure.
Emergency Life-Support Procedures:
Acute exposure to dimethyldichlorosilane may require decontamination and life
support for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to dimethyldichlorosilane.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to dimethyldichlorosilane.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
-------
EFATG
CAS Registry Number: 75-78-5
Page 3 of 3
DIMETHYLDICHLOROSILANE
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. DO NOT induce vomiting or attempt to neutralize!
3. Rinse mouth with large amounts of water. Inform victims not to swallow
this water.
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
5. Activated charcoal is of no value.
6. Give the victims water or milk: Children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
7. RUSH to a health care facility.
-------
CAS Registry Number: 75-79-6
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - METHYLTRICHLOROSILANE
CAS Registry Number: 75-79-6
Synonyms: Methylsilyl Trichloride; Silane, Methyltrichloro-; Silane,
Trichloromethyl-; Trichloromethylsilane; Trichloromethylsilicon
Chemical Formula: CH3Cl3Si
Molecular Weight: 149.48
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(mouse) 0.00018 mg/liter/2 hour (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 152°F, 66.5°C (*Clayton and Clayton 1981-82)
Specific Gravity (H2O=1): 1.27 at 25°C (*CHRIS 1978)
Vapor Pressure (mmHg): Not Found
Melting Point: -108°F, -77.8°C (Weast 1983, p. C-515)
Vapor Density fAIR=l): 5.17 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Acrid odor, sharp like hydrochloric acid, colorless
liquid (*CHRIS 1978).
-------
CAS Registry Number: 75-79-6
Page 2 of 3
METHYLTRICHLOROSILANE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): As with other
chlorosilanes, acute exposures may be highly toxic and may cause death or
permanent injury after very short exposures to small quantitites. Chronic
exposures may be moderately toxic and involve irreversible and reversible
changes (*Sax 1975). Skin contact may produce severe burns with pain and
risk of secondary infections. Ingestion may produce oral, esophageal, and
stomach burns, intensity will vary from mild to very severe,
gastrointestinal damage is rare but may occur (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 45°F (OC); 15°F (CC) (*CHRIS 1978)
Flammable Limits:
LEL: 7.6% (*NFPA 1978)
UEL: 20% (*NFPA 1978)
Extinguishing Methods: Dry chemical or carbon dioxide may be used for
small fires. Water may be used for large fires if firefighters are
protected from violent reaction of methyltrichlorosilane with water. Water
may be used to keep containers cool (*NFPA 1978).
Special Fire Fighting Procedures: Self-contained breathing apparatus is
required as combustion/decomposition yields acid gases/pulmonary irritants.*
Corrosion-resistant protective clothing, as well as appropriate foot,
hand, arm, head, eye, and face protection are required where contact is
possible (*Encyc Occupat Health and Safety 1971).
Unusual Fire and Explosion Hazards: Toxic hydrogen chloride and phosgene
gases may form in fires. Reacts with water to form hydrochloric acid
(CHRIS 1987). Vapor forms flammable mixture with air (*NFPA 1978). May
form explosive mixture in air (*Hawley 1977).
NFPA Flammability Rating: 3
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*Hawley 1977; 'CHRIS 1978)
Stable:
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CAS Registry Number: 75-79-6
Page 3 of 3
METHYLTRICHLOROSILANE
SECTION V - REACTIVITY DATA (continued)
Conditions to Avoid: Contact with water or moist air (*NFPA 1978,
*Sax 1979).
Incompatibility (Materials to Avoid): Reacts with water or steam to form
hydrochloric acid ("CHRIS 1978).
Hazardous Decomposition or Byproducts: Hydrogen chloride and phosgene
formed in fires (*CHRIS 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Monomer for silicone resins (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Spills can be neutralized by flushing with large quantities of water
followed by treatment with sodium bicarbonate. Provide adequate protection
against generated hydrogen chloride. Do not allow water to get into
container since resulting pressure could cause container to rupture (*NFPA
1978). Protect against potentially violent reaction with water (see
Section III above). Avoid breathing vapors and contact with skin
(see Section III above).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 75-79-6
Page 1 of 3
Emergency First Aid Treatment Guide
for
METHYLTRICHLOROSILANE
(75-79-6)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless liquid.
Odor - Sharp, acrid.
Commercial Form - Liquid in 55-gallon drums or 1-gallon glass bottles.
Use - Manufacture of silicones.
Material to Avoid - Water (except for use in emergency life support).
Caution: Flammable liquid. Avoid sources of extreme heat or ignition
including sparks or fire.
Other Names - Methylsilyltrichloride, trichloromethylsilane,
trichloromethylsilicon.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W,
Ringer's lactate.
Signs and Symptoms of Acute Methyltrichlorosilane Exposure:
Warning: In the presence of water, methyltrichlorosilane liberates
hydrochloric acid, which is extremely corrosive. Caution is advised.
Signs and symptoms of acute ingestion of methyltrichlorosilane may include
excessive salivation, intense thirst, difficulty in swallowing, chills, pain,
and shock. Oral, esophageal, and stomach burns are common. Vomitus generally
has a coffee-ground appearance. The potential for circulatory collapse is high
following ingestion of methyltrichlorosilane.
-------
EFATG
CAS Registry Number: 75-79-6
Page 2 of 3
METHYLTRICHLOROSILANE
Acute inhalation exposure may result in hoarseness, laryngitis, a feeling of
suffocation, dyspnea (shortness of breath), choking, respiratory tract
irritation, chest pain, and pulmonary edema. Sneezing, bleeding of the nose
and gums, and ulceration of the nasal and oral mucosa may also occur. Renal
toxicity has been observed in animals.
If the eyes have come in contact with methyltrichlorosilane, then irritation,
pain, swelling, corneal erosion, and blindness may result Dermatitis (red,
inflamed skin), severe burns, pain, and shock generally follow dermal exposure.
Emergency Life-Support Procedures:
Acute exposure to methyltrichlorosilane may require decontamination and life
support for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to methyltrichlorosilane.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to methyltrichlorosilane.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
r
5. Wash exposed skin areas THOROUGHLY with soap and water.
-------
EFATG
CAS Registry Number: 75-79-6
Page 3 of 3
METHYLTRICHLOROSILANE
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Rinse mouth with large amounts of water. Inform victims not to swallow
this water.
3. DO NOT induce vomiting or attempt to neutralize!
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
5. Activated charcoal is of no value.
6. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
7. RUSH to a health care facility.
-------
CAS Registry Number: 75-86-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - ACETONE CYANOHYDRIN
CAS Registry Number: 75-86-5
Synonyms: 2-Cyano-2-Propanol; 2-Hydroxy-2-Methylpropionitrile;
2-Hydroxyisobutyronitrile; 2-Methyllactonitrile; 2-Propanone, Cyanohydrin;
alpha-Hydroxyisobutyronitrile; Lactonitrile, 2-Methyl-; Propanenitrile,
2-Hydroxy-2-Methyl-; USAF RH-8
Chemical Formula: C4H7NO
Molecular Weight: 85.10
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(Guinea Pig) 9 mg/kg (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 180°F, 82°C at 23 mmHg (Weast 1983, p. C-209)
Specific Gravity (H2O=1): 0.9267 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 0.8 at 20°C (*Clayton and Clayton 1981-82)
Melting Point: -2.2°F, -19°C (*Merck 1976)
Vapor Density (AIR-1): 2.93 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Freely soluble in water (*Merck 1976)
Appearance and Odon Colorless liquid (*Hawley 1977); distinct strong
cyanide odor (*Lefaux 1968)
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CAS Registry Number: 75-86-5
Page 2 of 4
ACETONE CYANOHYDRIN
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Patty 1963)
Skin: Yes (*Patty 1963)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): This material is considered
very hazardous and should only be handled under conditions that prevent any
inhalation of vapor or skin contact (*Patty 1963). May be slightly
irritating to skin and mucous membranes (*Merck 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 165°F, 74°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: 2.2% (*NFPA 1978)
UEL: 12% (*NFPA 1978)
Extinguishing Methods: Water may cause frothing if it gets below surface
of liquid and turns to steam. Water fog gently applied to surface will
cause frothing which will extinguish fire. Use water spray, dry chemical,
alcohol foam, or carbon dioxide. Use water to keep fire-exposed containers
cool, from a safe distance (*NFPA 1978).
Special Fire Fighting Procedures: Wear air-supplied mask with canister
approved for use with acrylonitrile in less than 2 percent concentration,
rubber or plastic gloves, cover goggles or face mask, rubber boots, slicker
suit, safety helmet (*CHRIS 1978).
Unusual Fire and Explosion Hazards: Too dangerous to health to expose
fire fighters; a few whiffs of vapor could cause death; vapor or liquid
could be fatal on penetrating normal protective clothing. Vapor forms
explosive mixture with air (*NFPA 1978). On contact with sulfuric acid, it
may explode (*Sax 1979).
NFPA Flammability Rating: 1
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
-------
CAS Registry Number: 75-86-5
Page 3 of 4
ACETONE CYANOHYDRIN
SECTION V (continued)
Conditions to Avoid: Vapor forms explosive mixtures with air (*NFPA
1978)
Incompatibility (Materials to Avoid): May react violently with water
(*NFPA 1978). Contact with sulfuric acid may cause it to explode (*Sax
1979).
Hazardous Decomposition or Byproducts: Decomposes when heated to 248°F or
at lower temperature under alkaline conditions, emitting highly toxic
hydrogen cyanide (*NFPA 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Used in the manufacture of insecticides (*Hawley 1977) and as a chemical
intermediate (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material. Use water spray to reduce vapors. Small
spills: take up with sand or other noncombustible absorbent material and
place into containers for later disposal. Large spills: dike far ahead of
spill for later disposal (DOT 1984, Guide 55). Prevent any inhalation
of vapor or skin contact (*Patty 1963).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Nausea, loss of consciousness,
convulsions (*Clayton and Clayton 1982); irregular heart beat, headache,
vomiting (*Patty 1963). Slightly irritating to the skin (*Merck 1976).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration
(avoid mouth to mouth resuscitation). If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
-------
CAS Registry Number: 75-86-5
Page 4 of 4
ACETONE CYANOHYDRIN
SECTION IX (continued)
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation. Avoid
contact with contaminated skin (DOT 1984, Guide 55; *Rumack 1975 to
Present).
-------
CAS Registry Number: 76-02-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY ~ TRICHLOROACETYL CHLORIDE
CAS Registry Number: 76-02-8
Synonyms: (NIOSH/RTECS 1985 Synonyms On-Line File) Acetyl Chloride,
Trichloro-; Trichloroacetic Acid Chloride; Trichloroacetochloride
Chemical Formula: CC13COC1
Molecular Weight: 181.83
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LC50 inhalation (mouse) 0.445 mg/liter (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 244°F, 118°C (Hawley 1981, p. 1040)
Specific Gravity (H2O=1): 1.654 at 0°C/4°C (Hawley 1981, p. 1040)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Decomposes (Weast 1979, p. C-98)
Appearance and Odor: Liquid (Hawley 1981, p. 1040)
-------
CAS Registry Number: 76-02-8
Page 2 of 4
TRICHLOROACETYL CHLORIDE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIHTLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1040)
Skin: Yes (Hawley 1981, p. 1040)
Ingestion: Yes (Hawley 1981, p. 1040)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic by ingestion
and inhalation; strong Irritant to skin and tissues (Hawley 1981, p. 1040).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Material may react violently with water.
Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam
(DOT 1984, Guide 59).
Special Fire Fighting Procedures: Move container from fire area if you
can do so without risk. Spray cooling water on containers that are exposed
to flames until well after fire is out. Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Wear positive pressure breathing apparatus and special protective clothing
(DOT 1984, Guide 59).
Unusual Fire and Explosion Hazards: Material may burn but does not ignite
readily. Poisonous if inhaled or swallowed; skin contact poisonous.
Contact may cause burns to skin and eyes (DOT 1984, Guide 59).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
-------
CAS Registry Number: 76-02-8
Page 3 of 4
TRICHLOROACETYL CHLORIDE
SECTION V (continued)
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Not Found
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section III above). Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal. Keep unnecessary
people away; isolate hazard area and deny entry. Stay upwind; keep out of
low areas (DOT 1984, Guide 59).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Contact may cause burns to skin and eyes
(DOT 1984, Guide 59).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be delayed;
keep victim under observation (DOT 1984, Guide 59).
-------
CAS Registry Number: 76-02-8
Page 4 of 4
TRICHLOROACETYL CHLORIDE
COMMENTS
Sources searched but no information found:
NIOSH/RTECS 1983
ACGIH 1983
NIOSH/OSHA 1978
Merck 1983
Sax 1984
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Gosselin 1984
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Oilman 1985
-------
CAS Registry Number: 77-47-4
Page 1 of 4
EPA' CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - HEXACHLOROCYCLOPENTADIENE
CAS Registry Number: 77-47-4
Synonyms: 1,3-Cyclopentadiene, 1,2,3,4,5,5-Hexachloro-; C 56; Graphlox;
HCCPD; Hexachlorocyclopentadien; Hexachloropentadiene; HRS 1655; NCI-C55607;
PCL; Perchlorocyclopentadiene
Chemical Formula: CSC16
Molecular Weight: 272.77
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LC50 inhalation (rat) 0.018 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 100 (pounds)
RQ: 1 (pounds) (statutory); 100 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 462°F, 239°C at 753 mmHg (*Weast 1984)
Specific Gravity (H2O=1): 1.7019 at 25°C/4°C (*Weast 1984)
Vapor Pressure (mmHg): 0.080 at 25°C (*Clayton and Clayton 1981-82)
Melting Point: 16°F, -9°C (*Weast 1984)
Vapor Density (AIR=1): 9.4 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 800 ppb (*Clayton and Clayton 1981-82)
Appearance and Odor: Yellow-green liquid (*Weast 1984) with a pungent
odor (*Hawley 1981)
-------
CAS Registry Number: 77-47-4
Page 2 of 4
HEXACHLOROCYCLOPENTADIENE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: TWA 0.1 mg/ms (0.01 ppm) (ACGIH 1986-87, p.20)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Hawley 1981)
Skin: Yes (*Hawley 1981)
Ingestion: Yes (*Hawley 1981)
Health Hazards (Acute, Delayed, and Chronic): This compound is very toxic
and may be fatal if inhaled, swallowed, or absorbed through the skin. The
probable human lethal dose is 50-500 mg/kg, or between 1 teaspoon and 1
ounce for a 150 Ib. (70 kg) person. Severe exposure induces pulmonary
hyperemia and edema, degenerative and necrotic changes in brain, heart and
adrenal glands and necrosis of liver and kidney tubules (*DOT 1984;
Gosselin 1984, p. 11-169).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Non-flammable (*Hawley 1981)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use dry chemical, carbon dioxide, water spray or
foam for small fires. For large fires, use water spray, fog, or foam.
Move hexachlorocyclopentadiene from fire area if this can be done without
risk (*DOT 1984).
Special Fire Fighting Procedures: Isolate hazard area and deny entry.
Wear positive pressure breathing apparatus and special protective clothing.
Fight fire from maximum distance. Dike fire control water for later
disposal (*DOT 1984).
Unusual Fire and Explosion Hazards: Toxic hydrogen chloride, chlorine,
and phosgene gases may form in fires. In presence of moisture, will
corrode iron and other materials; flammable and explosive hydrogen gas may
collect in enclosed space (Weiss 1980, p. 498).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 77-47-4
Page 3 of 4
HEXACHLOROCYCLOPENTADIENE
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Reacts slowly with water to form hydrochloric
acid; however, the reaction is not hazardous (Weiss 1980, p. 498).
Incompatibility (Materials to Avoid): Will corrode iron and other metals
in the presence of moisture (Weiss 1980, p. 498).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 498)
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Major uses of hexachlorocyclopentadiene include applications as a chemical
intermediate for insecticides and flame retardants (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard and deny entry. Stay upwind
and keep out of low areas. Ventilate closed spaces before entering. Do
not touch spilled material; stop leak if this can be done without risk.
Use water spray to reduce vapors. Absorb small spills with sand or other
noncombustible absorbent material and place into containers for later
disposal. Dike far ahead of large spills for later disposal (*DOT 1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/LIMITED
Nitrile POOR/LIMITED
Viton GOOD/LIMITED
*Based on qualitative performance information.
**Based on a chemical analog.
-------
CAS Registry Number: 77-47-4
Page 4 of 4
HEXACHLOROCYCLOPENTADIENE
*
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Inhalation of mist is highly irritating
to mucous membranes, causing tearing, sneezing, and salivation. Eye
contact may result in severe irritation. Contact of liquid with the skin
may cause blistering and burning (*CHRIS 1978). Headaches and throat
irritation have also been reported as a result of exposure to this compound
(Clayton and Clayton 1981, p. 3751).
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with the material,
immediately flush skin or eyes with running water for at least 15 minutes.
Speed in removing material from the skin is of extreme importance. Keep
victim quiet and maintain normal body temperature. Since effects may be
delayed, keep victim under observation (*DOT 1984).
-------
CAS Registry Number: 77-78-1
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - DIMETHYL SULFATE
CAS Registry Number: 77-78-1
Synonyms: Dimethyl Monosulfate; Dimethyl Sulphate; DMS; DMS (Methyl Sulfate);
Methyl Sulfate; Sulfuric Acid, Dimethyl Ester; Dimethylsulfate
Chemical Formula: C2H6O4S
Molecular Weight: 126.14
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LC50 inhalation (mouse) 0.28 mg/liter (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds) (statutory); 100 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: About 370°F, 188°C (with decomposition) (*Merck 1983)
Specific Gravity (H2O=1): 1.3283 at 20°C (*Weast 1979)
Vapor Pressure (mmHg): 0.1 at room temperature (*IARC 1972-1985); 0.5 at
20°C (NIOSH/OSHA 1978, p. 90)
Melting Point: -25.15°F, -31.75°C (*Weast 1979)
Vapor Density (AIR=1): 4.35 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 2.8 g/100 mL at 18°C (*Merck 1983)
Appearance and Odor: It is a colorless oily liquid (*Merck 1983) with a
faint, onion-like odor (*NFPA 1978)
-------
CAS Registry Number: 77-78-1
Page 2 of 4
DIMETHYL SULFATE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 5 mg/ms (1 ppm) (NIOSH 1987, p. 110)
ACGIH TLV: TWA 0.5 mg/m3 (0.1 ppm) (skin) (ACGIH 1985, p. 17)
IDLH: 10 ppm (NIOSH/OSHA 1978, p. 90)
Other Limits Recommended: Industrial substance suspect of carcinogenic
potential for man (ACGIH 1985, p. 42).
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Acute: extremely toxic
vapors and liquid — a few whiffs or contact on skin could be fatal (*NFPA
1978). Also acutely toxic if ingested. Delayed effects which are
ultimately fatal may also occur (*Merck 1983). Lethal concentrations as
low as 97 ppm/10 min have been reported in humans. DNA inhibition and
damage to human somatic cells, and sister chromatid exchange in human
fibroblast cells were observed (*NIOSH/RTECS 1985). Delayed appearance of
symptoms may permit unnoticed exposure to lethal quantities (Merck 1983, p.
475).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 182°F (CC) (*Hawley 1977)
Flammable Limits: Moderate fire potential when exposed to heat or flame
(*Sax 1975)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: To extinguish small fires use water, foam, carbon
dioxide, and dry chemicals (*Sax 1975). For large fires use water spray,
fog, or foam. Move container from fire area if you can do it without risk.
Cool containers exposed to flames with water. Fight fire from a maximum
distance (DOT 1984, Guide 57).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special protective clothing. Dike fire control water for
later disposal. Do not scatter material (DOT 1984, Guide 57).
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: 2
-------
CAS Registry Number: 77-78-1
Page 3 of 4
DIMETHYL SULFATE
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*IARC 1972-1985)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Material is normally stable even
under fire exposure conditions and is not hazardously reactive with water
(*NFPA 1978). It is incompatible with strong oxidizers and strong ammonia
solutions (NIOSH/OSHA 1978, p. 90).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Used as a chemical intermediate for quaternary ammonium salts and for
alkylation of phenols and thiols ("'SRI), and as a methylating agent in the
manufacture of many organic chemicals (*Merck 1983). Formerly, dimethyl
sulfate was used as a war gas. It is also used in the manufacture of dyes,
perfumes, for the separation of mineral oils, and for the analysis of auto
fluids (*Browning 1965).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
If spilled in a building, the building must be evacuated and the agent
decomposed by hosing with water or spraying with 5 percent sodium hydroxide
(caustic soda) (*Dreisbach 1977). For large spills, evaporating
vapors can be collected in a chamber with a gas cleaning device
(*NIOSH/OSHA 1981).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Immediate effects of vapor exposure are
eye irritation, cough, swelling of tongue, lips, and larynx, and lungs
-------
CAS Registry Number: 77-78-1
Page 4 of 4
DIMETHYL SULFATE
SECTION IX (continued)
(later). Ingestion or direct contact with mucous membranes causes
corrosion. Once absorbed, lung damage and liver and kidney injury will
occur (*Dreisbach 1977). Liquid dermal exposure causes blistering,
followed by convulsions, delirium, coma, and death in severe cases (*Merck
1983).
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, start artificial respiration; if
breathing is difficult, give oxygen. If dermal contact occurs, immediately
flush with water for 15 minutes. It is very important to quickly remove
material from skin. Remove and isolate contaminated clothing and shoes at
the site. Keep victim quiet and maintain normal body temperature. Since
effects may be delayed, keep a close watch on the victim (DOT 1984, Guide
57).
-------
CAS Registry Number: 77-81-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - TABUN
CAS Registry Number: 77-81-6
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 127) Phosphoramido-
cyanidic Acid, Dimethyl-, Ethyl Ester; Dimethylamidoethoxyphosphoryl Cyanide;
Dimethylphosphoramidocyanidic Acid, Ethyl Ester; Ethyl Dimethylamidocyano-
phosphate; Ethyl N,N-Dimethylphosphoramidocyanidate; Ethyl N,N-Dimethylamino
Cyanophosphate; GA; LE-100; MCE; T-2104; TL 1578
Chemical Formula: C5H11N2O2p
Molecular Weight: 162.15
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LD50 skin (mouse) 1 mg/kg (*NIOSH/RTECS 1985)
TPQ: 10 (pounds)
RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 464°F, 240°C (Merck 1983, p. 1297)
Specific Gravity (H2O=1): 1.073 (U.S. Army 1975, p. 3-2)
Vapor Pressure (mmHg): 0.07 at 25°C (U.S. Army 1975, p. 3-2)
Melting Point: -58°F, -50°C (Merck 1983, p. 1297)
Vapor Density (AIR=1): 5.63 (U.S. Army 1975, p. 3-2)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (Merck 1976, p. 1297).
-------
CAS Registry Number: 77-81-6
Page 2 of 4
TABUN
SECTION II (continued)
Appearance and Odor: Colorless to brown liquid; faint fruity odor (U.S.
Army 1975, p.3-2)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (U.S. Army 1975, p. 3-2)
Skin: Yes (U.S. Army 1975, p. 3-2)
Ingestion: Yes (U.S. Army 1975, p. 3-2)
Health Hazards (Acute, Delayed, and Chronic): This material is toxic by
inhalation and by absorption through skin and eyes. The lethal dose for
humans may be as low as 0.01 mg/kg (Merck 1983, p. 1297). Tabun is a nerve
agent; it acts as a cholinesterase inhibitor. The median lethal dosage
(respiratory) is 400 mg-minute/m3 for humans; the median incapacitating
dosage is 300 mg-minute/m3. Respiratory lethal dosages kill in 1 to 10
minutes; liquid in the eye kills nearly as rapidly. Skin absorption great
enough to cause death may occur in 1 to 2 minutes, but may be delayed for 1
to 2 hours (U.S. Army 1975, p. 3-3).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 172°F (Sax 1984, p. 1335)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific - Poison A, Liquid) Extinguish
with alcohol foam, carbon dioxide, or dry chemical (Student 1981, p. 56)
Special Fire Fighting Procedures: Complete protection required; have
available decontaminants (bleach, alkali) and atropine (U.S. Army 1975, p.
3-2). Bleaching powder (chlorinated line) destroys Tabun but gives rise to
cyanogen chloride (Merck 1983, p. 1297).
Unusual Fire and Explosion Hazards: Extremely poisonous (Merck 1983, p.
1297). (Non-Specific — Poison A, Liquid) Keep away from sparks, flames,
and sources of ignition. Keep out of water sources and sewers (Student
1981, p. 56).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 77-81-6
Page 3 of 4
TABUN
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (U.S. Army 1975, p. 3-3)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Avoid water and acids (U.S. Army
1975, p. 3-2). Can react with oxidizing materials (Sax 1984, p. 1335).
Hazardous Decomposition or Byproducts: Hydrolysis forms hydrogen cyanide
(U.S. Army 1975, p. 3-2). When heated to decomposition, it emits very
toxic fumes of oxides of phosphorus and nitrogen (Sax 1984, p. 1335).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
This material is a chemical warfare agent (Merck 1983, p. 1297).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Poison A, Liquid) When handling, avoid breathing vapors,
keep upwind, avoid bodily contact with the material, and upon skin contact
wash with soap and water (Student 1981, p. 56). Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
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CAS Registry Number: 77-81-6
Page 4 of 4
TABUN
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Nerve agent symptoms include difficulty
in breathing, drooling, nausea, vomiting, cramps, involuntary defecation
and urination, twitching, jerking, staggering, headache, confusion,
drowsiness, coma, and convulsion. Inhalation causes dimness of vision and
pinpointing of the pupils (U.S. Army 1975, p. 3-2).
Emergency and First Aid Procedures: The toxic effects of tabun are
similar to parathion (Sax 1984, p. 1335). First aid for parathion is as
follows: move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 55).
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CAS Registry Number: 78-00-2
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - TETRAETHYLLEAD
CAS Registry Number: 78-00-2
Synonyms: Lead, Tetraethyl-; NCI-C54988; Plumbane, Tetraethyl-; TEL;
Tetraethyl Lead, Liquid; Tetraethyl Lead; Tetraethylplumbane
Chemical Formula: C8H20Pb
Molecular Weight: 323.45
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LD50 oral (rat) 12.3 mg/kg
TPQ: 100 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): In Lead Compounds category
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: About 392°F, 200°C (*Merck 1983); decomposes between 110
and 200°C (Verschueren 1983, p. 1085)
Specific Gravity (H2O=1): 1.653 at 20°C (*Merck 1983)
Vapor Pressure (mmHg): 0.2 at 20°C (*IARC 1972-1985)
Melting Point: -202°F, -130°C (*IARC 1972-1985)
Vapor Density (AIR=1): 8.6 (NFPA 1984, p. 325M-86)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*IARC 1972-1985)
Appearance and Odor: Colorless liquid with a pleasant odor (Hawley 1981,
p. 1006)
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CAS Registry Number: 78-00-2
• Page 2 of 3
TETRAETHYLLEAD
SECTION III - HEALTH HAZARD DATA
OSHA PEL: 0.075 mg (lead)/m3 (NIOSH 1987, p.220)
ACGIH TLV: 0.100 mg (lead)/m3 (skin) (ACGIH 1986-87, p.30)
IDLH: 40 mg (lead)/m3 (NIOSH 1987, p. 220)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Venugopal 1978)
Skin: Yes (*Venugopal 1978)
Ingestion: Yes (*Venugopal 1978)
Health Hazards (Acute, Delayed, and Chronic): Extremely poisonous; may be
fatal if inhaled, swallowed, or absorbed from the skin. Contact may cause
burns to skin and eyes (*DOT 1984). Most symptoms-of poisoning are due to
the effects of tetraethyllead on the nervous system (*Gilman 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 200°F (no method given) (NFPA 1984, p. 325M-86)
Flammable Limits:
LEL: 1.8 percent by volume (NFPA 1984, p. 325M-86)
UEL: Not Found
Extinguishing Methods: Water spray may be used because the material can
be cooled below its flash point (*NFPA 1978).
Special Fire Fighting Procedures: Fire fighting should be done from an
explosive-resistant location. Use water from unmanned monitors and
hose-holders to keep fire-exposed containers cool. When stopping leak, use
water spray to protect firefighters (*NFPA 1978). Runoff from fire control
or dilution water may cause pollution (*DOT 1984).
Unusual Fire and Explosion Hazards: May explode in fires (*CHRIS 1978).
NFPA Flammability Rating: 2
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*IARC 1972-1985)
Stable:
Conditions to Avoid: Decomposes slowly at room temperature and more
rapidly at elevated temperatures (*IARC 1972-1985).
Incompatibility (Materials to Avoid): Not Found
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CAS Registry Number: 78-00-2.
Page 3 of 3
TETRAETHYLLEAD
SECTION V (continued)
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Virtually all of the tetraethyllead produced in the USA is used as an
antiknock additive for gasolines (*IARC 1972-1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Tetraethyllead is hazardous, but areas may be entered with extreme care.
No skin surface should be exposed. Use water spray to disperse vapors
(*NFPA 1978). Outdoors, stay upwind and keep out of low areas.
Isolate hazard area (*DOT 1984).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 78-00-2
Page 1 of 3
Emergency First Aid Treatment Guide
for
TETRAETHYLLEAD
(78-00-2)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless, oily liquid.
Odor - Pleasant, sweet odor.
Commercial Form - 98% pure liquid dyed red or other distinctive color.
Uses - Aviation gasoline, antiknock agent, ethylating agent.
Materials to Avoid - Oxidizers.
Caution: Flammable liquid. When burned, toxic fumes of lead oxide will be
emitted. Avoid sources of extreme heat or ignition including sparks or fire.
Other Names - Lead tetraethyl, tetraethylplumbane, TEL.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal,
saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam,
phenytoin, phenobarbitol, mannitol, dexamethasone.
Signs and Symptoms of Acute Tetraethyllead Exposure:
Warning: Effects may be delayed for hours to days. Caution is advised.
Signs and symptoms of acute exposure to tetraethyllead may be severe and
include anxiety, irritability, insomnia, violent/frightening dreams, headache,
disorientation, hyperexcitability, delusions, and hallucinations. Muscular
weakness, ataxia, tremors, convulsions, cerebral edema, and coma may occur.
A metallic taste may be noted. Sneezing, bronchitis, and pneumonia may be
observed. Bradycardia (slow heart rate), hypotension (low blood pressure),
hypothermia, and pallor may also occur. Gastrointestinal symptoms include
vomiting and diarrhea. Tetraethyllead may irritate moist skin, eyes, and
mucous membranes.
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CAS Registry Number: 78-00-2
Page 2 of 3
TETRAETHYLLEAD
Emergency Life-Support Procedures:
Acute exposure to tetraethyllead may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to tetraethyllead.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to tetraethyllead.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
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CAS Registry Number: 78-00-2
Page 3 of 3
TETRAETHYLLEAD
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims
are conscious and alert.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. RUSH to a health care facility.
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CAS Registry Number: 78-34-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - DIOXATHION
CAS Registry Number: 78-34-2
Synonyms: l,4-Dioxan-2,3-diyl Bis(O,O-Diethyl Phosphorothiolothionate);
l,4-Dioxan-2,3-Diyl O,O,O',0'-Tetraethyl Di(Phosphorodithioate); 1,4-Dioxane-
2,3-S,S'-Bis(O,O-Diethyl Dithiophosphate); 2,3-Bis(Diethoxyphosphinothioylthio)-
1,4-Dioxane; 2,3-Dioxane S,S-Bis(O,O-Diethylphosphorodithioate); 2,3-
Dioxanedithiol S,S-Bis(O,O-Diethyl Phosphorodithioate); AC 528; Bercotox;
Delnatex; Delnav; Dioxation; Dioxothion; ENT 22,897; Hercules 528; Hercules
AC528; Kavadel; Navadel; NCI-C00395; p-Dioxane-2,3-Dithiol, S,S-Diester with
O,O-Diethyl Phosphorodithioate; p-Dioxane-2,3-diyl Ethyl Phosphorodithioate;
Phosphorodithioic Acid, S,SM,4-Dioxane-2,3-diyl O,O,O',O'-Tetraethyl Ester;
Phosphorodithioic Acid, S,S'-p-Dioxane-2,3-diyl O,O,O',O'-Tetraethyl Ester;
Ruphos
Chemical Formula: C12H26O6P2S4
Molecular Weight: 456.54
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LC50 inhalation (mouse) 0.34 mg/liter/1 hour (*NIOSH/RTECS 1985).
TPQ: 500 (pounds)
RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: Not Found
Specific Gravity (H2O=1): 1.257 at 26°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: -4°F, -20°C (*Merck 1983)
Vapor Density (AIR=»1): Not Found
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CAS Registry Number: 78-34-2
Page 2 of 4
DIOXATHION
SECTION II (continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (*Merck 1983)
Appearance and Odor: Tan liquid (*Merck 1983). (Technical) Brown liquid
(*Martin 1974).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: 0.2 mg/m3 (skin) (ACGIH 1985, p. 17)
IDLH: Not Found
Other Limits Recommended: ADI 0.0015 mg/kg (*Hayes 1975).
Routes of Entry: Inhalation: Yes (*Hawley 1977)
Skin: Yes (Farm Chemicals Handbook 1984, p. C-82)
Ingestion: Yes (*Hawley 1977)
Health Hazards (Acute, Delayed, and Chronic): Very toxic. Probable oral
lethal dose for humans is 50-500 mg/kg or between 1 teaspoonful and 1 oz.
for a 70 kg (150 Ib.) person (*Gosselin 1976). It is a cholinesterase
inhibitor (*Hawley 1977). Death is primarily due to respiratory arrest
arising from failure of the respiratory center, paralysis of respiratory
muscles, intense bronchoconstriction, or all three (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Organophosphorus Pesticide,
Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific — Organophosphorus
Pesticide, Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate contaminated
clothing at the site. Move container from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
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CAS Registry Number: 78-34-2
Page 3 of 4
DIOXATHION
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Shock can shatter container,
releasing contents (*Sax 1975). (Non-Specific — Organophosphorus
Pesticide, Liquid, n.o.s.) Container may explode in heat of fire. Fire
may produce irritating or poisonous gases. Runoff from fire control water
may give off poisonous gases. Runoff from fire control or dilution water
may cause pollution (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stabler Yes (*ACGIH 1979)
Conditions to Avoid: Avoid alkali materials and heat. It is unstable
to iron or tin surfaces and when mixed with certain carriers (*Martin
1974).
Incompatibility (Materials to Avoid): Avoid alkali materials (*Martin
1974)
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits highly toxic fumes of oxides of nitrogen, phosphorus, and sulfur
(*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Dioxathion is used for control of insects and mites on grapes, citrus,
walnuts, ornamentals, apples, pears, and quince. Also used as a spray or
dip for the control of ticks, lice, hornfly, and sheep ked on cattle,
goats, sheep, and hogs (Farm Chemicals Handbook 1984, p. C-82).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific - Organophosphorus Pesticide, Liquid, n.o.s.) Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them.
Remove and isolate contaminated clothing at the site. Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55).
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CAS Registry Number: 78-34-2
Page 4 of 4
DIOXATHION
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 78-34-2
Page 1 of 3
Emergency First Aid Treatment Guide
for
DIOXATHION
(78-34-2)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Tan liquid.
Commercial Forms - Brown emulsifiable concentrate or wettable powder.
Use - Pesticide.
Other Names - Delnatex; Delnav; Deltic; l,4-dioxan-2,3-diyl bis(O,O-diethyl
phosphorothiolothionate); Dioxation; Kavadel; Navadel.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
atropine, pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Dioxathion Exposure:
Note: Dioxathion is a cholinesterase inhibitor.
Acute exposure to dioxathion may produce the following signs and symptoms:
pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and
profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may
also occur. The heart rate may decrease following oral exposure or increase
following dermal exposure. Hypotension (low blood pressure) may occur
although hypertension (high blood pressure) is not uncommon. Chest pain may be
noted. Respiratory symptoms include dyspnea (shortness of breath),
respiratory depression, and respiratory paralysis. Psychosis may occur.
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CAS Registry Number: 78-34-2
Page 2 of 3
DIOXATHION
Emergency Life-Support Procedures:
Acute exposure to dioxathion may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to dioxathion.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to dioxathion.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin area three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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CAS Registry Number: 78-34-2
Page 3 of 3
DIOXATHION
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of dioxathion is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of dioxathion may result in sudden onset of seizures
or loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 78-53-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - AMITON
CAS Registry Number: 78-53-5
Synonyms: (NIOSH/RTECS SYNONYMS 1983, Volume 3, p. 150) Phosphorothioic
Acid, S-(2-(Diethylamino)Ethyl) O,0-Diethyl Ester; Chipman 6200; Citram;
S-(Diethylaminoethyl) O,O-Diethyl Phosphorothioate; Diethyl
S-2-Diethylaminoethyl Phosphorothioate; (2-Diethylamino)Ethylphosphorothioic
Acid O,O-Diethyl Ester; O,O-Diethyl S-2-Diethylaminoethyl Phosphorothioate;
O,O-Diethyl S-Diethylaminoethyl Phosphorothiolate; O,O-Diethyl S-2-Diethyl-
aminoethyl Phosphorothiolate; O,O-Diethyl S-(beta-Diethylamino)Ethyl
Phosphorothiolate; O,O-Diethyl S-(2-Diethylaminoethyl) Thiophosphate; DSDP; ENT
24,980-X; Inferno; Metramac; Metramak; R-5,158; Rhodia-6200; Tetram
Chemical Formula: C10H24NO3PS
Molecular Weight: 269.38
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LD50 oral (rat) 3.3 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 230°F, 110°C at 0.2 mm (Sax 1984, p. 1008)
Specific Gravity (H2O=»1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=»1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
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CAS Registry Number: 78-53-5
Page 2 of 4
AMITON
SECTION II (continued)
Solubility in Water: Not Found
Appearance and Odor: Liquid (Merck 1983, p. 73)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1009)
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1009)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic orally. It is a cholinesterase inhibitor (Sax 1984, p. 1009).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Organophosphorus Pesticide,
Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific — Organophosphorus
Pesticide, Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate contaminated
clothing at the site. Move container from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, can
emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur (Sax 1984,
p. 1009). (Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.)
Container may explode in heat of fire. Fire may produce irritating or
poisonous gases. Runoff from fire control water may give off poisonous
gases. Runoff from fire control or dilution water may cause pollution (DOT
1984, Guide 55).
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CAS Registry Number: 78-53-5
Page 3 of 4
AMITON
SECTION IV (continued)
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Extreme heat (Sax 1984, p. 1009)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Very toxic nitrogen oxides,
phosphorus oxides, and sulfur oxides when heated to decomposition (Sax
1984, p. 1009).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
This material is used as an acaricide and insecticide (Farm Chemicals
Handbook 1984, p. C222).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them.
Remove and isolate contaminated clothing at the site. Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
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CAS Registry Number: 78-53-5
Page 4 of 4
AMITON
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: The toxic effects are similar to
parathion (Sax 1984, p. 1009). Symptoms of parathion poisoning include
anorexia, nausea, vomiting, diarrhea, excessive salivation, pupillary
constriction, bronchoconstriction, muscle twitching, convulsions, coma,
respiratory failure. Effects are cumulative (Sax 1984, p. 2119).
Emergency and First Aid Procedures: Effects are similar to those of
parathion (Sax 1984, p. 1009). First aid procedures for parathion are as
follows: move victim to fresh air; call emergency medical care. If not
breathing, perform artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 55).
-------
CAS Registry Number: 78-71-7
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - OXETANE, 3,3-BIS(CHLOROMETHYL)-
CAS Registry Number: 78-71-7
Synonyms: (NIOSH/RTECS 1985 Synonyms On-Line File) 3,3-Bis
(Chloromethyl)Oxetane; Penton; 3,3-bis(Chloromethyl)-1 -Oxacyclobutane
Chemical Formula: C5H8C120
Molecular Weight: 155
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LC60 inhalation (mouse) 0.2 mg/liter/2 hours (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 217°F, 103°C at 30 mmHg (Beilstein 1974, Volume 17/1,
p. 68)
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 66°F, 19°C (Beilstein 1974, Volume 17/1, p. 68)
Vapor Density (AIR=«1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
-------
CAS Registry Number: 78-71-7
Page 2 of 3
OXETANE, 3,3-BIS(CHLOROMETHYL)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 78-71-7
Page 3 of 3
OXETANE, 3,3-BIS(CHLOROMETHYL)
SECTION VI - USE INFORMATION
Penton is the trademark for a thermoplastic resin derived from
3,3-bis(chloromethyl)oxetane. Penton is a linear polymer used for solid and
lined valves, pumps, pipe and fittings, and a monofilament for filter
supports and column packing (Hawley 1981, p. 785).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Not Found
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Not Found
Emergency and First Aid Procedures: Not Found
COMMENTS:
Sources searched but no information found:
Weast 1979
Merck 1983
Sax 1984
DOT 1984
NFPA 1984
Student 1981
Weiss 1980
Doull 1980
Clayton and Clayton 1981-82
Encyc Occupat Health and Safety 1983
CHRIS 1978
Hayes 1982
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CAS Registry Number: 78-82-0
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - ISOBUTYRONITRILE
CAS Registry Number: 78-82-0
Synonyms: 2-Methylpropanenitrile; 1-Cyano-l-Methylethane; 2-Cyanoprbpane;
2-Methylpropane Nitrile; 2-Methylpropionitrile; Dimethylacetonitrile; Isopropyl
Cyanide; Isopropyl Nitrile; Isopropylcyanide; Propanenitrile, 2-Methyl-;
Propanoic Acid, 2-Methyl-, Nitrile
Chemical Formula: C4H7N
Molecular Weight: 69.1
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LD50 oral (mouse) 25 mg/kg (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 219°F, 103.8°C (*Weast 1979)
Specific Gravity (H2O=1): 0.7608 at 30°C/4°C (*Weast 1979); 0.733 at 20°C
(*Hawley 1977)
Vapor Pressure (mmHg): Not Found
Melting Point: -96.7°F, -71.5°C (*Weast 1979)
Vapor Density (AIR=1): 2.38 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly (*Weast 1979)
Appearance and Odor: Colorless liquid (*Hawley 1977)
-------
CAS Registry Number: 78-82-0
Page 2 of 4
ISOBUTYRONITRILE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Occupational exposure to nitriles —
recommended standard in air: TWA 22 mg/ms (*NIOSH/RTECS 1985).
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 577)
Skin: Yes (Hawley 1981, p. 577)
Ingestion: Yes (Hawley 1981, p. 577)
Health Hazards (Acute, Delayed, and Chronic): Poisonous; may be fatal if
inhaled, swallowed, or absorbed through skin. Contact may cause burns to
skin and eyes (DOT 1984, Guide 28). (Non-Specific - Nitriles) Primarily,
they are skin and eye irritants. Large doses cause collapse and stop
breathing (Clayton and Clayton 1981-82, p. 4846).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 47°F, 8°C (*NFPA 1978)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, foam, or fog (DOT 1984, Guide 28).
Special Fire Fighting Procedures: Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas. Wear
positive pressure breathing apparatus and special protective clothing.
Isolate for 1/2 mile in all directions if tank car or truck is involved in
fire. Move container from fire area if you can do so without risk. Dike
fire control water for later disposal; do not scatter the material. Spray
cooling water on containers that are exposed to flames until well after
fire is out. Withdraw immediately in case of rising sound from venting
safety device or any discoloration of tank due to fire (DOT 1984, Guide
28).
Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an
enclosed area (Weiss 1980, p. 531). Toxic oxides of nitrogen are produced
during combustion (Student 1981, p. 297). It is a flammable/combustible
material and may be ignited by heat, sparks, or flames. Vapors may travel
to a source of ignition and flash back. Container may explode in heat of
fire. Vapor explosion and poison hazard indoors, outdoors or in sewers.
Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 28).
NFPA Flammability Rating: 3
-------
CAS Registry Number: 78-82-0
Page 3 of 4
ISOBUTYRONITRILE
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 531)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits toxic fumes of oxides of nitrogen (Sax 1984, p. 1639).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 531)
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
It is used in organic synthesis (*Patty 1963); as an intermediate for
insecticides (Hawley 1981, p. 577); and as a gasoline additive (Clayton and
Clayton 1981-82, p. 4873).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep sparks, flames, and other sources of ignition away. Keep material out
of water sources and sewers. Build dikes to control flow as necessary.
Attempt to stop leak if this can be done without hazard. Use water spray
to disperse vapors and dilute standing pools of liquid. Avoid breathing
vapors. Keep upwind. Avoid bodily contact with the material. Do not
handle broken packages without protective equipment. Wash away any
material which may have contacted the body with copious amounts
of water or soap and water (Student, 1981, p. 297). Wear positive
pressure breathing apparatus and special protective clothing. Shut
off ignition sources; no flares, smoking, or flames in hazard area.
Do not touch spilled material. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible absorbent
material and place into containers for later disposal. Large spills:
dike far ahead of spill for later disposal (DOT 19^4, Guide 28).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 78-82-0
Page 4 of 4
ISOBUTYRONITRILE
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED**
PE POOR/LIMITED**
PVC POOR/LIMITED**
Viton GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 78-82-0
Page 1 of 3
Emergency First Aid Treatment Guide
for
ISOBUTYRONITRILE
(78-82-0)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Caution: Isobutyronitrile toxicity can occur via ingestion, dermal/eye
contact, or inhalation; death may occur within minutes. IMMEDIATELY begin
administering 100% oxygen and RUSH victims to a health care facility!
Substance Characteristics:
Pure Form - Colorless liquid.
Commercial Form - Liquid in tank cars.
Uses - Chemical intermediate, pesticide intermediate, gasoline additive.
Caution: Flammable liquid. Avoid sources of extreme heat or ignition
including sparks or fire. Isobutyronitrile will liberate toxic nitrogen oxide
fumes when heated to decomposition.
Other Names - 1-Cyano-l-methylethane, isopropyl cyanide, isopropyl nitrile,
2-methylpropane nitrile.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, saline cathartic or
sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote kit (amyl
nitrite ampule, sodium nitrite, sodium thiosulfate), sodium bicarbonate,
diazepam, phenytoin.
Signs and Symptoms of Acute Isobutyronitrile Exposure:
Warning: Heart palpitation may occur within minutes after exposure. High
doses can stop breathing. Vital signs should be monitored closely. Caution is
advised.
-------
EFATG
CAS Registry Number: 78-82-0
Page 2 of 3
ISOBUTYRONITRILE
Signs and symptoms of acute exposure to isobutyronitrile may include
hypertension (high blood pressure) and tachycardia (rapid heart rate),
followed by hypotension (low blood pressure) and bradycardia (slow heart rate).
Cherry-red (and potentially bloody) mucous membranes, cardiac arrhythmias, and
other cardiac abnormalities are common. Cyanosis (blue tint to skin and mucous
membranes) may also be found.
Tachypnea (rapid respiratory rate) may be followed by respiratory depression.
Lung hemorrhage and pulmonary edema may occur. Headache, vertigo (dizziness),
agitation, giddiness, salivation, nausea, and vomiting may be followed by
combative behavior, convulsions, and coma.
Isobutyronitrile is irritating to the skin and mucous membranes. Lacrimation
(tearing) and a burning sensation of the mouth and throat are common.
Emergency Life-Support Procedures:
Acute exposure to isobutyronitrile may require decontamination and life support
for the victims. All exposed persons should be transported to a health care
facility as quickly as possible. Emergency personnel should wear protective
clothing appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to isobutyronitrile.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen mask. Direct oral contact with isobutyronitrile-
contaminated persons or their gastric contents may result in self-
poisoning.
3. RUSH to a health care facility!
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to isobutyronitrile.
-------
EFATG
CAS Registry Number: 78-82-0
Page 3 of 3
ISOBUTYRONITRILE
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen mask. Direct oral contact with isobutyronitrile-
contaminated persons or their gastric contents may result in self-
poisoning.
3. RUSH to a health care facility!
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Remove contaminated clothing as soon as possible.
6. Wash exposed skin areas twice with soap and water.
7. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen mask. Direct oral contact with isobutyronitrile-
contaminated persons or their gastric contents may result in self-
poisoning.
2. RUSH to a health care facility!
3. DO NOT induce vomiting or attempt to neutralize!
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
5. Activated charcoal is of no value.
-------
CAS Registry Number: 78-94-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - METHYL VINYL KETONE
CAS Registry Number: 78-94-4
Synonyms: l-Buten-3-one; 2-Butenone; 3-Buten-2-one; 3-Butene-2-one; Acetone,
Methylene-; Acetyl Ethylene; Butenone; Delta(3)-2-Butenone; Gamma-Oxo-
Alpha-Butylene; Ketone, Methyl Vinyl; Methylene Acetone; Methylvinyl Ketone;
Vinyl Methyl Ketone
Chemical Formula: C4H6O
Molecular Weight: 70.09
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
LC50 inhalation (rat) 0.007 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 10 (pounds)
RQ: 1 (pounds) (statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 179°F, 81.4°C (*Merck 1983)
Specific Gravity (H2O=1): 0.8636 at 20°C/4°C; 0.8407 at 25°C/4°C (*Merck
1983)
Vapor Pressure (mmHg): Not Found
Melting Point: 20°F, -7°C (*CHRIS 1978)
Vapor Density (AIR=«1): 2.41 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Merck 1983)
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CAS Registry Number: 78-94-4
Page 2 of 4
METHYL VINYL KETONE
SECTION II (continued)
Appearance and Odor: Colorless liquid (*Hawley 1981) with pungent odor
(*Merck 1983)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Similar to other ketones) (*Rumack
1975 to Present)
Skin: Yes (*Merck 1983)
Ingestion: Yes (*DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): This material is readily
absorbed through the skin, causing general poisoning (*Merck 1983) similar
to other ketones; inhalation has central nervous system depressant effects
(*Rumack 1975 to Present). It is irritating to mucous membranes and
respiratory tract (*Merck 1983) and to the skin; it is a lachrymator and
can cause eye injury (*Grant 1974).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 20°F, -6.6°C (CC) (*Hawley 1981);
30°F, -U°C (OC) (*CHRIS 1978)
Flammable Limits:
LEL: 2.1% (*NFPA 1978)
UEL: 15.6% (*NFPA 1978)
Extinguishing Methods: Use dry chemical, alcohol foam, 'or carbon dioxide.
Water spray may be ineffective as an extinguishing agent (*NFPA 1978).
Small fires: dry chemical, carbon dioxide, and foam. Large fires: fog or
foam. Move container from fire area if you can do so without risk. Dike
fire control water for later disposal; do not scatter the material. Spray
cooling water on containers that are exposed to flames until well after
fire is out. Withdraw immediately in case of rising sound from venting
safety device or any discoloration of tank due to fire (DOT 1984, Guide
28).
Special Fire Fighting Procedures: Use water to keep fire-exposed
containers cool (*NFPA 1978). Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Wear positive
pressure breathing apparatus and special protective clothing. Isolate for
-------
CAS Registry Number: 78-94-4
Page 3 of 4
METHYL VINYL KETONE
SECTION IV (continued)
1/2 mile in all directions if tank car or truck is involved in fire (DOT
1984, Guide 28).
Unusual Fire and Explosion Hazards: Vapors form flammable mixtures with
air, and may travel a considerable distance to a source of ignition and
flash back. Polymerization may take place in containers, possibly with
violent rupture of containers (*NFPA 1978). Upon exposure to heat or
flame, it emits toxic and irritating fumes (*Sax 1979). Container may
explode in heat of fire. Vapor explosion and poison hazard indoors,
outdoors, or in sewers (DOT 1984, Guide 28).
NFPA Flammability Rating: 3
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Polymerizes on standing (*Merck 1983)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Yes (*NFPA 1978)
May Not Occur:
Conditions to Avoid: Heat or sunlight (*NFPA 1978)
SECTION VI - USE INFORMATION
This material is used as an alkylating agent, a starting material for
plastics, and an intermediate in the synthesis of steroids and Vitamin A
(*Merck 1983).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section III above). Isolate area. Stay upwind;
keep out of low areas. Shut off ignition sources; no flares,
smoking, or flames in hazard area. Do not touch spilled material; stop
leak if you can do so without risk. Use water spray to reduce vapors.
Absorb small spills with sand or other noncombustible absorbent material
and place into containers for later disposal. For large spills, dike far
ahead for later disposal (*DOT 1984).
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CAS Registry Number: 78-94-4
Page 4 of 4
METHYL VINYL KETONE
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
CPE POOR/LIMITED**
Neoprene POOR/LIMITED**
PE POOR/LIMITED**
PVC POOR/LIMITED**
Viton POOR/LIMITED**
Viton/Neoprene POOR/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Liquid or high concentration of vapors
causes blistering of the skin (*NFPA 1978). Similar to other ketones; can
cause sore throat, sneezing, coughing, and salivation. Inhalation may
cause nausea and vomiting; inhalation of high concentrations can cause
headache, dizziness, fainting, tremor, uncoordination, lowered body
temperature, depressed respiratory and heart rate, gasping, coma, and
death. Direct aspiration of liquid into lungs can cause chemical
pneumonia. (*Rumack 1975 to Present)
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at site. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Keep victim
quiet and maintain normal body temperature. Effects may be delayed; keep
victim under observation (*DOT 1984).
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CAS Registry Number: 78-97-7
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - LACTONITRILE
CAS Registry Number: 78-97-7
Synonyms: 2-Hydroxypropanenitrile; 2-Hydroxypropionitrile; Acetaldehyde
Cyanohydrin; Acetocyanohydrin; alpha-Hydroxypropionitrile; Ethylidene
Cyanohydrin; Propanenitrile, 2-Hydroxy-; Propanoic Acid, 2-Hydroxy-, Nitrile
Chemical Formula: C3H5NO
Molecular Weight: 71
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 skin
(rabbit) 20 mg/kg
TPQ: 1,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 360-363°F, 182-184°C; slight decomposition (Weast 1979, p.
C-456)
Specific Gravity (H2O=1): 0.9877 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 10 at 74°C (*Patty 1963)
Melting Point: -40°F, -40°C (*Weast 1979)
Vapor Density (AIR-1): 2.45 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in all proportions (*Weast 1979)
Appearance and Odor: Straw colored liquid (*Patty 1963)
-------
CAS Registry Number: 78-97-7
Page 2 of 3
LACTONITRILE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and Safety
1971)
Skin: Yes (*Encyc Occupat Health and Safety 1971)
Ingestion: Yes (*Encyc Occupat Health and Safety
1971)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic by oral,
skin, or eye contact (*Patty 1963)
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 170°F (TCC) (Sax 1984, p. 1683)
Flammable Limits: Moderate when exposed to heat or flame (*Encyc Occupat
Health and Safety 1971)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Foam, carbon dioxide, dry chemical (Sax 1984, p.
1683).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Cyanide fumes released when heated to
decomposition (*Encyc Occupat Health and Safety 1971).
NFPA Flammability Rating: 2
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Alkali (*Hawley 1977); oxidizing
material (Sax 1984, p. 1683).
Hazardous Decomposition or Byproducts: Cyanide fumes when heated to
decomposition (*Encyc Occupat Health and Safety 1971); hydrocyanic acid in
presence of alkali (*Hawley 1977).
-------
CAS Registry Number: 78-97-7
Page 3 of 3
LACTONITRILE
SECTION V (continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Solvent — intermediate in production of ethyl lactate and lactic acid
(*Hawley 1977).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not breathe vapors or touch spilled material (see Section III above).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED**
PE POOR/LIMITED**
PVC POOR/LIMITED**
Viton GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 78-97-7
Page 1 of 3
Emergency First Aid Treatment Guide
for
LACTONITRILE
(78-97-7)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Caution: Lactonitrile toxicity can occur via ingestion, dermal/eye contact, or
ingestion; death may occur within minutes. IMMEDIATELY begin administering
100% oxygen and rush victims to a health care facility.
Substance Characteristics:
Pure Form - Straw-colored liquid.
Commercial Form - 95 to 97% pure liquid in carboys.
Uses - Chemical intermediate, solvent.
Materials to Avoid - Alkali, oxidizers.
Caution: Toxic hydrogen cyanide gas may be released upon contact with alkali
or when heated to decomposition.
Other Names - Acetaldehyde cyanohydrin, ethylidene cyanohydrin,
2-hydroxypropanenitrile, 2-hydroxypropionitrile.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May be Required:
Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline
cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote
kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium
bicarbonate, diazepam, phenytoin.
Signs and Symptoms of Acute Lactonitrile Exposure:
Warning: Heart palpitations may occur within minutes after exposure. Caution
is advised. Vital signs should be monitored closely. Symptoms may be delayed.
Signs and symptoms of acute exposure to lactonitrile may include hypertension
(high blood pressure) and tachycardia (rapid heart rate), followed by
hypotension (low blood pressure) and bradycardia (slow heart rate). Cherry-red
mucous membranes and blood, cardiac arrhythmias, and other cardiac
abnormalities are common."7 Cyanosis (blue tint to the skin and mucous
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CAS Registry Number: 78-97-7
Page 2 of 3
LACTONITRILE
membranes) may be present following exposure to lactonitrile. Salivation,
nausea, and vomiting may also occur.
Tachypnea (rapid respiratory rate) may be followed by respiratory depression.
Lung hemorrhage and pulmonary edema may occur. Headache, vertigo (dizziness),
agitation, and giddiness may be followed by combative behavior, convulsions,
paralysis, protruding eyeballs, dilated and unreactive pupils, and coma.
Lactonitrile is irritating to the skin and mucous membranes. Lacrimation
(tearing) and a burning sensation of the mouth and throat are common.
Emergency Life-Support Procedures:
Acute exposure to lactonitrile may require decontamination and life support for
the victims. All exposed persons should be transported to a health care
facility as quickly as possible. Emergency personnel should wear protective
clothing appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to lactonitrile.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen mask. Direct oral contact with lactonitrile-contaminated
persons or their gastric contents may result in self-poisoning.
3. RUSH to a health care facility!
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to lactonitriie.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
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CAS Registry Number: 78-97-7
Page 3 of 3
LACTONITRILE
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen mask. Direct oral contact with lactonitrile-contaminated
persons or their gastric contents may result in self-poisoning.
3. RUSH to a health care facility!
4. Remove contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
6. Wash exposed skin areas twice with soap and water.
7. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen mask. Direct oral contact with lactonitrile-contaminated
persons or their gastric contents may result in self-poisoning.
2. RUSH to a health care facility!
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. DO NOT induce vomiting. Ipecac is not recommended for ingestion of
lactonitrile.
5. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
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CAS Registry Number: 79-06-1
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ACRYLAMIDE
CAS Registry Number: 79-06-1
Synonyms: 2-Propenamide; Acrylic Amide; Ethylene Carboxamide; Propenamide;
Propenoic Acid, Amide
Chemical Formula: CSH5NO
Molecular Weight: 71.08
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302:
Chemical does not meet the toxicity criteria but because of its
high production volume and recognized toxicity it is considered
a chemical of concern.
TPQ: 1,000/10,000 (pounds)
RQ: 5000 (pounds)
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: 189°F, 87°C at 2 mmHg (*Merck 1976)
Specific Gravity (H2O=1): 1.122 at 30°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 0.007 at 20°C (*ACGIH 1980)
Melting Point: 184°F, 84.5°C (*Merck 1976)
Vapor Density (AIR=1): 2.45 (*Sax 1975)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 215.5 g/100 mL water at 30°C (*Merck 1976)
Appearance and Odor: Odorless (*Grant 1974) white, crystalline solid
(*Sax 1975).
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CAS Registry Number: 79-06-1
Page 2 of 4
ACRYLAMIDE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Air: TWA 0.3 mg/ms (skin) (OSHA 1984, p. 660)
ACGIH TLV: TWA 0.3 mg/ms; STEL 0.6 mg/ms (skin) (*ACGIH 1981)
IDLH: Not Found
Other Limits Recommended: NIOSH: 0.3 mg/ms 10 hr TWA (NIOSH 1987, p.46).
It is recommended that no more than 0.05 mg/kg/day be absorbed by workers
(*ACGIH 1980). Suspected of carcinogenic potential in humans; notice of
intent to change to 0.03 mg/ms for 1985-86 (ACGIH 1985, p. 42).
Routes of Entry: Inhalation: Yes (NIOSH/OSHA 1978, p. 43)
Skin: Yes (*Hamilton 1974)
Ingestion: Yes (NIOSH/OSHA 1978, p. 43)
Health Hazards (Acute, Delayed, and Chronic): Classified as very toxic;
probable oral lethal human dose is between 50 and 500 mg/kg or between. 1
teaspoon and 1 ounce for a 150 Ib. person (Gosselin 1984, p. 11-409).
Polymerized acrylamide is not toxic, but the monomer can cause peripheral
nerve damage (*Doull 1980). It is a cumulative neurotoxin and repeated
exposure to small amounts may cause serious injury to the nervous system
(*Rumack 1975 to Present). The neurological effects may be delayed.
Polymer inhibitors or stabilizers added to the monomer may also produce
toxicity (*Peer Review Committee). The symptoms of acrylamide toxicity are
consistent with mid-brain lesions (*Hamilton 1974) and blocked transport
along both motor and sensory axons (*Doull 1980).
Medical Conditions Generally Aggravated by Exposure: Individuals with
nervous system diseases should not be exposed to acrylamide (*Plunkett
1976).
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 138°C (CC) (*Sunshine 1969)
Flammable Limits:
LEL: Not Found;
UEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon dioxide,
water spray or foam. For large fires use water spray, fog or foam. Move
container from fire area if you can do so without risk (*DOT 1984).
Special Fire Fighting Procedures: Fight fire from maximum distance. Dike
fire control water for later disposal; do not scatter the material (*DOT
1984).
Unusual Fire and Explosion Hazards: Heating to decomposition evolves
ammonia, hydrogen and carbon monoxide (*Rumack 1975 to Present).
NFPA Flammability Rating: Not Found
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CAS Registry Number: 79-06-1
Page 3 of 4
ACRYLAMIDE
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Hawley 1977)
Conditions to Avoid: Heat (*ACGIH 1980); ultraviolet light (*Merck
1976).
Incompatibility (Materials to Avoid): Strong oxidizers (NIOSH/OSHA 1978,
P. 42).
Hazardous Decomposition or Byproducts: Pure acrylamide will decompose at
175-300°C giving ammonia, hydrogen and carbon monoxide (*Rumack 1975 to
Present).
Hazardous Polymerization: May Occur: Yes (*ACGIH 1980)
May Not Occur:
Conditions to Avoid: It readily polymerizes when heated to the
melting point or when exposed to ultraviolet light (*Merck 1976). It
is known to polymerize with violence when heated (*ACGIH 1980).
SECTION VI -- USE INFORMATION
Reactive monomer and intermediate in production of organic chemicals,
polymers or copolymers (*ACGIH 1980); the latter are used as or in
flocculants for sewage and waste treatment; soil conditioning agents; ore
processing; adhesives; paper and textile industries; permanent press
fabrics (*Hawley 1977).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Remove and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do so without risk. Use water
spray to reduce vapors. Small spills: absorb with sand or other
non-combustible absorbent materal and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (*DOT 1984).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
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CAS Registry Number: 79-06-1
Page 4 of 4
ACRYLAMIDE
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED**
Neoprene POOR/LIMITED**
Nitrile POOR/LIMITED**
PE POOR/LIMITED**
Viton POOR/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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CAS Registry Number: 79-06-1
Page 1 of 3
Emergency First Aid Treatment Guide
for
ACRYLAMIDE
(79-06-1)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - White crystalline solid.
Odor - None.
Commercial Form - Shipped in fiber drums.
Uses - Manufacture of polymers, dyes, and adhesives; flocculant for sewage and
waste treatment; soil conditioning; ore processing.
Caution: Avoid sources of heat including fire. Acrylamide will polymerize
violently when heated.
Other Names - Acrylic amide, ethylene carboxamide, 2-propenamide.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal,
saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate.
Signs and Symptoms of Acute Acrylamide Exposure:
Warning: Effects may be delayed. Caution is advised.
Acrylamide is a cumulative neurotoxin. Signs and symptoms of acute exposure
may include drowsiness, fatigue, memory loss, confusion, hallucinations,
tingling of fingers, loss of vibration and position senses, tremor, muscular
weakness, disturbances of balance (especially with the eyes closed), and
dysarthria (incoordination of the muscles used for speaking).
Excessive sweating of the feet and hands may also occur. Contact with
acrylamide may irritate or burn the skin, eyes, and mucous membranes.
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CAS Registry Number: 79-06-1
Page 2 of 3
ACRYLAMIDE
Emergency Life-Support Procedures:
Acute exposure to acrylamide may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to acrylamide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to acrylamide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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CAS Registry Number: 79-06-1
Page 3 of 3
ACRYLAMIDE
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 79-11-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - CHLOROACETIC ACID
CAS Registry Number: 79-11-8
Synonyms: Acetic Acid, Chloro-; alpha-Chloroacetic Acid; Chloracetic Acid;
Chloroethanoic Acid; MCA; MKHUK; Monochloracetic Acid; Monochloroacetic Acid;
Monochloroacetic Acid Solution; Monochloroethanoic Acid; NCI-C60231
Chemical Formula: C2H3C1O2
Molecular Weight: 94.50
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.18 mg/L
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: 372°F, 189°C (*Merck 1976)
Specific Gravity (H2O=1): 1.4043 at 40°C (*Weast 1979)
Vapor Pressure (mmHg): 1 at 43°C (*Patty 1963)
Melting Point: 145°F, 63°C (*Weast 1979)
Vapor Density (AIR=1): 3.26 (*Sax 1975)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble in water (*Weast 1979)
Appearance and Odor: Colorless or white crystals (*Merck 1976).
Colorless to light brown crystals (*Hawley 1977).
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CAS Registry Number: 79-11-8
Page 2 of 4
CHLOROACETIC ACID
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Encyc Occupat Health and Safety 1971)
Ingestion: Yes (*Encyc Occupat Health and Safety
1971)
Health Hazards (Acute, Delayed, and Chronic): This material is very
toxic. The probable lethal oral dose is 50-500 mg/kg of body weight,
between one teaspoon and one ounce, for a 150 Ib. person. Chloroacetic
acid is irritating to the skin, cornea, and respiratory tract and causes
burns. It may severely damage skin and mucous membranes. Ingestion may
interfere with essential enzyme systems and cause perforation and
peritonitis. Burns to skin result in marked fluid and electrolyte loss.
Death may follow if more than 3% of the skin is exposed to this material.
Other health hazards include central nervous system depression, and
respiratory system depression (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Persons with lung
diseases are at greater risk (*ITI 1982).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 302°F, 150°C (*NFPA 1978)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Water fog applied gently to surface will cause
frothing which will extinguish fire. Normal fire fighting procedures may
be used (*NFPA 1978). Extinguish fire using agent suitable for
surroundings. Material itself does not burn or burns with difficulty.
(*Student 1981) For small fires use dry chemical, carbon dioxide, water
spray or foam. For large fires use water spray, fog, or foam (*DOT 1984).
Special Fire Fighting Procedures: This material is extremely hazardous to
health, but fire fighters may enter areas with extreme care. Full
protective clothing including a self-contained breathing apparatus, coat,
pants, gloves, boots and bands around legs, arms and waist should be
provided. No skin surface should be exposed (*NFPA 1978). Cool
fire-exposed containers with water (*Student 1981). Move container from
fire area if you can do so without risk. Spray cooling water on containers
that are exposed to flames until well after fire is out (*DOT 1984).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits highly toxic fumes of phosgene and chlorides (*Sax 1975). Water may
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CAS Registry Number: 79-11-8
Page 3 of 4
CHLOROACETIC ACID
SECTION IV (continued)
cause frothing if it gets below surface of the liquid and turns to steam
(*NFPA 1978). Flammable/poisonous gases may accumulate in tanks and hopper
cars. Some of these materials may ignite combustibles, e.g., wood, paper,
oil (*DOT 1984).
NFPA Flammability Rating: 1
SECTION V « REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Heating (*Sax 1975)
Incompatibility (Materials to Avoid): It is corrosive to metals (*Student
1981).
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits highly toxic fumes of phosgene and chlorides (*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Chloroacetic acid is used as a pre-emergence herbicide. It is also used as
a defoliant (*Martin and Worthing 1974). It is an intermediate for
synthetic caffeine (*NIOSH 1984) as well as sarcosine, EDTA, and
ethylchloroacetate (*ITI 1982) and sodium carboxymethylcellulose, glycine,
thioglycolic acid, Pharmaceuticals like Vitamin A and indigoid dyes (*SRI).
Additional uses include disinfectant and as a drying agent for curing hay
(USEPA/Pesticide Index 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Neutralize spilled materials with crushed limestone, soda ash, or lime
(*Student 1981). Waste water containing chloroacetic acid can be treated
with ammonia, ammonium salts, or amines followed by separation of suspended
solids (*Opavsky 1976). Keep unnecessary people away; isolate hazard and
deny entry. Stay upwind; keep out of low areas. Notify authorities if
water pollution occurs. Do not touch spilled material. Stop leak if you
can without risk. Take up small spills with an absorbent, non-combustible
material and place into clean, dry containers for later disposal. Dike
large spills far ahead of spill for later disposal (*DOT 1984).
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CAS Registry Number: 79-11-8
Page 4 of 4
CHLOROACETIC ACID
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
PE POOR/MANY
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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CAS Registry Number: 79-11-8
Page 1 of 3
Emergency First Aid Treatment Guide
for
CHLOROACETIC ACID
(79-11-8)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless, white or light brown crystals.
Odor - Penetrating; similar to vinegar.
Commercial Forms - 99.5% pure liquid or solid in drums.
Uses - Chemical intermediate, herbicide, preservative, disinfectant, drying
agent for hay, medicinal treatment of keratoses.
Caution: Avoid sources of extreme heat including fire. Chloroacetic acid will
emit toxic fumes of phosgene and chlorides when heated to decomposition.
Other Names - Chloroethanoic acid, MCA, monochloroacetic acid.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W,
Ringer's lactate.
Signs and Symptoms of Acute Chloroacetic Acid Exposure:
Warning: Effects may be delayed. Caution is advised. Chloroacetic acid is
extremely corrosive.
Signs and symptoms of acute ingestion of Chloroacetic acid may be severe and
include salivation, intense thirst, difficulty in swallowing, chills, and
shock. Oral, esophageal, and stomach burns are common and often associated
with severe pain. Vomitus generally has a coffee-ground appearance. The
potential for circulatory collapse is high following ingestion of Chloroacetic
acid.
Acute inhalation exposure may result in sneezing, hoarseness, choking,
laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and
chest pain. Bleeding of nose and gums, ulceration of the nasal and oral
mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur.
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CAS Registry Number: 79-11-8
Page 2 of 3
CHLOROACETIC ACID
If the eyes have come in contact with chloroacetic acid, then irritation, pain,
swelling, corneal erosion, and blindness may result. Dermal exposure may
result in dermatitis (red, inflamed skin), severe burns, and pain.
Emergency Life-Support Procedures:
Acute exposure to chloroacetic acid may require decontamination and life
support for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to chloroacetic acid.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to chloroacetic acid.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
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CAS Registry Number: 79-11-8
Page 3 of 3
CHLOROACETIC ACID
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Rinse mouth with large amounts of water. Instruct victims not to swallow
this water.
3. DO NOT induce vomiting or attempt to neutralize!
4. Activated charcoal is of no value.
5. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims
are alert and conscious.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
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CAS Registry Number: 79-19-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- THIOSEMICARBAZIDE
CAS Registry Number: 79-19-6
Synonyms: l-Amino-2-Thiourea; 1-Aminothiourea; 2-Thiosemicarbazide;
Aminothiourea; Hydrazinecarbothioamide; Isothiosemicarbazide; N-Aminothiourea;
Thiocarbamoylhydrazine
Chemical Formula: CHSN3S
Molecular Weight: 91.15
SECTION I ~ REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(rat) 9.16 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 356-363°F, 180-184°C (*Hawley 1977)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Hawley 1977)
Appearance and Odor: This compound is a white crystalline powder and is
odorless (*Hawley 1977)
-------
CAS Registry Number: 79-19-6
Page 2 of 4
THIOSEMICARBAZIDE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 2575)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic by ingestion (Sax 1984, p. 2575). May induce goiter and cause
delayed toxic effects in blood and skin (*Rumack 1975 to Present). May be
mutagenic in human cells (*NIOSH/RTECS 1985).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Poisonous, Solid, n.o.s)
Extinguish with any chemical, carbon dioxide, water spray, fog, or foam
(DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Poisonous, Solid,
n.o.s.) Stay upwind; keep out of low areas. Wear self-contained (positive
pressure if available) breathing apparatus and full protective clothing.
Move container from fire area if you can do so without risk (DOT 1984,
Guide 53).
Unusual Fire and Explosion Hazards: When heated to decomposition, very
toxic fumes of sulfur oxides and nitrogen oxides are emitted (Sax 1984, p.
2575).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found -;
-------
CAS Registry Number: 79-19-6
Page 3 of 4
THIOSEMICARBAZIDE
SECTION V (continued)
Hazardous Decomposition or Byproducts: When heated to decomposition,
thiosemicarbazide emits very toxic fumes of oxides of sulfur and nitrogen
(Sax 1984, p. 2575).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
This compound is used as a reagent for ketones and certain metals, for
photography and as a rodenticide ("Hawley 1977). It is also effective for
control of bacterial leaf blight of rice (*Nippon Noyaku Gakkaishi 1976,
1(2)95). Not a registered pesticide in the U.S. (USEPA/Active Ingredients,
1985). It is a chemical intermediate for herbicides and a reagent for
detection of metals (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid skin contact, ingestion or inhalation (see Section III above).
(Non-Specific — Poisonous Solid, n.o.s.) Do not touch spilled material;
stop leak if you can do it without risk. Small spills: take up with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Thiosemicarbazide may induce goiter and
has also been reported to cause bone marrow depression with accompanying
decreases in white blood cells and platelets. It may also cause skin
irritation (*Rumack 1975 to Present).
Emergency and First Aid Procedures: For inhalation, remove victim to
fresh air and monitor for breathing difficulty. For eye exposure, irrigate
copiously with water for 15 minutes and follow with eye exam if pain
persists. For dermal exposure, wash skin twice with water and soap,
-------
CAS Registry Number: 79-19-6
Page 4 of 4
THIOSEMICARBAZIDE
SECTION IX (continued)
followed by exam if pain persists (*Rumack 1975 to Present). (Non-Specific
-- Poisonous, Solid, n.o.s.) Call emergency medical care. Remove and
isolate contaminated clothing and shoes at the site (DOT 1984, Guide 53).
-------
CAS Registry Number: 79-21-0
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PERACETIC ACID
CAS Registry Number: 79-21-0
Synonyms: Peroxyacetic Acid; Acetyl Hydroperoxide; Hydroperoxide, Acetyl;
Peracetic Acid Solution (Sax 1984, p. 2148); Ethaneperoxoic Acid (Merck 1983,
p. 1028)
Chemical Formula: C2H4O3
Molecular Weight: 76.05
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.45 ing/liter (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): Yes
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 221°F, 105°C (*Weast 1979)
Specific Gravity (H2O=1): 1.226 at 15°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: 32°F, 0.1°C (*Weast 1979); approximately -22°F, -30°C
(Hawley 1981, p. 786)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble (*Weast 1979)
Appearance and Odor: Colorless liquid (*NFPA 1978). Strong, pungent
acrid odor (*CHRIS 197S, *Merck 1983).
-------
CAS Registry Number: 79-21-0
Page 2 of 3
PERACETIC ACID
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*NFPA 1978)
Skin: Yes (Sax 1984, p. 2148)
Ingestion: Yes (*Gosselin 1984)
Health Hazards (Acute, Delayed, and Chronic): This is a very toxic
compound. The probable human oral lethal dose is 50-500 mg/kg, or between
1 teaspoon and 1 ounce for a 150 pound person (*Gosselin 1984).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): (Peracetic Acid, 60% Acetic Acid Solution)
105°F, 41°C (no method given) (NFPA 1984, p. 49-72)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Fight fires from an explosion-resistant location.
In advanced or massive fires, area should be evacuated (NFPA 1984, p.
49-72). For small fires: use dry chemical, carbon dioxide, water spray,
or foam. For large fires: flood area with water (DOT 1984, Guide 51).
Special Fire Fighting Procedures: If fire occurs in the vicinity of this
compound, water should be used to keep containers cool. Cleanup and
salvage operations should not be attempted until all of the peroxyacetic
acid solution has cooled completely (NFPA 1984, p. 49-72). Keep
unnecessary people away; wear self-contained breathing apparatus and full
protective clothing (DOT 1984, Guide 51).
Unusual Fire and Explosion Hazards: Decomposes violently at 230°F, 110°C
(NFPA 1984, p. 325M-78). When heated to decomposition, this compound emits
acrid smoke and fumes (Sax 1984, p. 2148). Runoff to sewer may create a
fire or explosion hazard (DOT 1984, Guide 51).
NFPA Flammability Rating: 2
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (NFPA 1984, p. 49-72)
Stable:
Conditions to Avoid: Shock and heat (NFPA 1984, p. 49-72).
-------
CAS Registry Number: 79-21-0
Page 3 of 3
PERACETIC ACID
SECTION V (continued)
Incompatibility (Materials to Avoid): Powerful oxidizer. Isolate from
other stored material, particularly accelerators, oxidizers, and organic or
flammable materials (NFPA 1984, p. 49-72).
Hazardous Decomposition or Byproducts: Emits acrid smoke and fumes when
heated to decomposition (Sax 1984, p. 2148).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (NFPA 1984, p. 49-72)
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
This compound is used as a bactericide and fungicide, especially in food
processing; a reagent in making caprolactam and glycerol; an oxidant for
preparing epoxy compounds; a bleaching agent; a sterilizing agent; and a
polymerization catalyst for polyester resins (*Hawley 1981; *SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section III above). Do not touch
the spilled material; shut off all ignition sources and stop the leak
if this can be done without risk (DOT 1984, Guide 51). The spilled
material should be absorbed with a noncombustible absorbent such as
vermiculite. Sweep up and place in a metal container for immediate
disposal. Do not use spark-generating metals or organic materials for
sweeping up or handling spilled material. Dispose of the absorbed
peroxyacetic acid solution, in small quantities at a time, by placing it on
the ground in a remote outdoor area and igniting with a long torch. Empty
containers should be washed with a 10% sodium hydroxide solution (NFPA
1984, p. 49-72).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 79-21-0
Page 1 of 3
Emergency First Aid Treatment Guide
for
PERACETIC ACID
(79-21-0)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Colorless liquid.
Odor - Strong, pungent, acrid.
Commercial Form - 40% solution in acetic acid contained in 65-lb glass carboys
and 250-lb aluminum drums.
Uses - Bactericide, fungicide, sterilizing agent, bleaching agent,
polymerization catalyst for polyester resins, manufacture of glycerol and epoxy
compounds.
Materials to Avoid - Organic materials, olefins.
Caution: Peracetic acid is a strong oxidizer. Fire or other violent reactions
may occur upon contact with combustible organic material.
Other Names - Acetic peroxide, acetyl hydroperoxide, Desoxon 1, ethaneperoxoic
acid, Obson AC, peroxyacetic acid.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, normal saline, D5W,
Ringer's lactate.
Signs and Symptoms of Acute Peracetic Acid Exposure:
Signs and symptoms of acute ingestion of peracetic acid may include corrosion
of mucous membranes of mouth, throat, and esophagus with immediate pain and
dysphagia (difficulty swallowing); ingestion may cause gastrointestinal tract
irritation. Inhalation of vapors or fumes may result in respiratory tract
irritation; peracetic acid is highly irritating to the skin and eyes.
-------
EFATG
CAS Registry Number: 79-21-0
Page 2 of 3
PERACETIC ACID
Emergency Life-Support Procedures:
Acute exposure to peracetic acid may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to peracetic acid.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to peracetic acid.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
-------
EFATG
CAS Registry Number: 79-21-0
Page 3 of 3
PERACETIC ACID
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. DO NOT induce vomiting or attempt to neutralize!
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Activated charcoal is of no value.
5. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults,
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
6. Transport to a health care facility.
-------
CAS Registry Number: 79-22-1
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- METHYL CHLOROFORMATE
CAS Registry Number: 79-22-1
Synonyms: Carbonochloridic Acid, Methyl Ester; Chlorocarbonic Acid, Methyl
Ester; Chloroformic Acid Methyl Ester; Formic Acid, Chloro-, Methyl Ester;
K-Stoff; Methoxycarbonyl Chloride; Methyl Chlorocarbonate; TL 438
Chemical Formula: C2H3C1O2
Molecular Weight: 94.50
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(mouse) 0.185 mg/liter/2 hours (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1,000 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 160°F, 71.0°C (*Merck 1976)
Specific Gravity (H2O=1): 1.223 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 3.26 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (Sax 1984, p. 1826)
Appearance and Odor: Clear liquid (*Merck 1976)
-------
CAS Registry Number: 79-22-1
Page 2 of 4
METHYL CHLOROFORMATE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1826)
Skin: Yes (Sax 1984, p. 1826)
Ingestion: Yes (Sax 1984, p. 1826)
Health Hazards (Acute, Delayed, and Chronic): Methyl chloroformate is
highly toxic upon inhalation and upon ingestion (*Merck 1976; Sax 1984, p.
1826). A concentration of 1 mg/liter (190 ppm) has been lethal in 10
minutes (*Clayton and Clayton 1981-82). It is corrosive and irritating to
skin (*Hawley 1977).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 54°F (no method given) (*Sax 1979)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon dioxide,
water spray, and foam. For large fires, use water spray, fog, or foam.
Move container from fire area if it can be done without risk. Cool
containers exposed to flames with water (DOT 1984, Guide 28).
Special Fire Fighting Procedures: Isolate for 1/2 mile in all directions
if tank car or truck is involved in fire. Wear positive pressure breathing
apparatus and special protective clothing (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: This chemical is very dangerous when
exposed to heat sources, sparks, flame, or oxidizers. It will react with
water or steam to produce toxic and corrosive fumes (*Sax 1979). Vapors
may travel to a source of ignition and flash back. Withdraw immediately in
case of rising sound from venting safety device or any discoloration of
tank due to fire (DOT 1984, Guide 28).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
-------
CAS Registry Number: 79-22-1
Page 3 of 4
METHYL CHLOROFORMATE
SECTION V (continued)
Conditions to Avoid: Heat or steam should be avoided (*Sax 1979).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Toxic fumes of phosgene are
produced when the material is heated to decomposition. Will react with
water or steam to produce toxic and corrosive fumes (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Methyl chloroformate is used in organic synthesis and in manufacturing of
insecticides (*Hawley 1977). It was used as a warfare agent during World
War I (*Clayton and Clayton 1981-82).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors and contact with skin (see Section III above). In
case of contact, immediately flush skin or eyes with water. Remove and
isolate contaminated clothing. Runoff from fire control or dilution
water should be contained for later disposal. In case of a small spill,
take up with sand or other noncombustible absorbent material and place in
containers for later disposal. In case of a large spill, dike far ahead of
the spill for later disposal. In case of spills or leaks, shut off
ignition sources, and have no flares, smoking, or flames in hazard area.
Do not touch spilled material and use water spray to reduce vapors (DOT
1984, Guide 28).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/LIMITED
*Based on qualitative performance information.
**Based on a chemical analog.
-------
CAS Registry Number: 79-22-1
Page 4 of 4
METHYL CHLOROFORMATE
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: It is an irritant to the skin and is
corrosive by ingestion or inhalation. Concentrations of 10 ppm have caused
lachrymation and a concentration of 190 ppm for 10 minutes has been lethal
to humans. Irritation of the lung and eyes may persist after cessation of
exposure. Skin allergies may also occur (*Clayton and Clayton 1981-82).
After 2-3 inhalations, brief initial irritation may occur followed by
massive symptoms (heavy cough) after 36 hours. Relapses may occur in
following days with eventual full recovery (*Schuckmann 1972).
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration; if
breathing is difficult, provide oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact, immediately flush skin
or eyes with water for at least 15 minutes. Keep victim quiet and maintain
normal body temperature. Since effects may be delayed, keep careful watch
on the victim (DOT 1984, Guide 28).
-------
CAS Registry Number: 80-63-7
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - METHYL 2-CHLOROACRYLATE
CAS Registry Number: 80-63-7
Synonyms: 2-Chloroacrylic Acid, Methyl Ester; 2-Propenoic Acid, 2-Chloro-,
Methyl Ester; Acrylic Acid, 2-Chloro-, Methyl Ester; Methyl
Alpha-Chloroacrylate; Propenoic Acid, 2-Chloro-, Methyl Ester
Chemical Formula: C4H5C1O2
Molecular Weight: 120.54
SECTION I ~ REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.5 mg/liter/2 hours (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 126°F, 52°C at 51 mmHg (*Weast 1979)
Specific Gravity (H2O=1): 1.189 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Colorless liquid (*Lefaux 1968)
-------
CAS Registry Number: 80-63-7
Page 2 of 3
METHYL 2-CHLOROACRYLATE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Lefaux 1968)
Skin: Yes (*Lefaux 1968)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): It is a skin, eye, and lung
irritant. The least trace on skin raises large blisters. It is also a
respiratory poison; breathing the vapors can cause pulmonary edema (*Lefaux
1968).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Poisonous Liquid, n.o.s.) Small
fires: dry chemical, carbon dioxide, water spray, or foam. Large fires:
water spray, fog, or foam. Move container from fire area if you can do so
without risk (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Fight fire from maximum distance. Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them. Wear
positive pressure breathing apparatus and special protective clothing (DOT
1984, Guide 55).
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
-------
CAS Registry Number: 80-63-7
Page 3 of 3
METHYL 2-CHLOROACRYLATE
SECTION V (continued)
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Used to make acrylic high polymer with properties closely resembling those
of polymethylmethacrylate (*Lefaux 1968). Monomer for specialty polymers
(e.g., aircraft glazing) (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Poisonous Liquid, n.o.s.) Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Remove and isolate
contaminated clothing at the site. Stop leak if you can do so without
risk. Use water spray to reduce vapors. Small spills: take up with sand
or other noncombustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 55).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: A trace on skin causes large blisters.
Inhalation of high concentrations may cause rapid breathing, headache,
nausea, lethargy, pulmonary edema, convulsions, and death (Gosselin 1984,
p. 11-409).
Emergency and First Aid Procedures: (Non-Specific — Poisonous Liquid,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Remove and isolate contaminated clothing and shoes at the site.
In case of contact with material, immediately flush skin or eyes with
running water for at least 15 minutes. Speed in removing material from
skin is of extreme importance. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 55).
-------
CAS Registry Number: 81-81-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY ~ WARFARIN
CAS Registry Number: 81-81-2
Synonyms: Coumarin,3-(alpha-Acetonylbenzyl)-4-Hydroxy-; l-(4'-hydroxy-
3'-coumarinyl)-l-phenyl-3-butanone; 2H-l-benzopyran-2-one, 4-hydroxy-3-
(3-oxo-1 -phenylbutyl); 3-( 1 '-pheny 1-2'- acetylethyl)-4-hydroxycoumarin;
3-(alpha-acetonylbenzyl)-4-hydroxycoumarin; 200 Coumarin; Athrombine-K;
Brumolin; Compound 42; Coumadin; Coumafen; Coumafene; Coumarin, 3-(alpha-
acetonylbenzyl)-4-hydroxy; Coumarin, 4-hydroxy-3(l-phenyl-3-oxo-butyl)-;
Coumefene; D-Con; Dethmor; Dethnel; Eastern States Duocide; Fasco Fascrat
Powder; Frass-Ratron; Kumader; Kumadu; Kypfarin; Maag Rattentod Cum; Mar-Frin;
Maveran; Prothromadin; Rat-a-way; Rat-b-gon; Rat-Gard; Rat-Kill; Rat-Mix;
Rat-ola; Ratron; Rats-No-More; Rodafarin; Temus W; Warf 42; Warf Compound 42;
Warf-12; Warfarat; Warficide; Zoocoumarin; Co-Rax; Cov-R-Tox; Liqua-Tox;
Martin's Mar-Frin; Mouse- Pak; Rat and Mice Bait; Rat-o-cide #2; Rat-trol;
Ratorex; Ratox; Ratoxin; Ratron G; Rax; Ro-deth; Rodex, Rodex Blox; Rosex;
Rough and Ready Mouse Mix; Solfarin; Spray-trol Brand Roden-trol; Tox-Hid; Twin
light rat away; Vampirinip II & III; Waran; Warfarin plus; Warfarin Q;
3-(alpha-Phenyl-beta- Acetylethyl)-4-Hydroxycoumarin; 3-(Acetonylbenzyl)-
4-Hydroxycoumarin; 4-Hydroxy-3(3-oxo-l-Phenylbutyl)-2H-l-Benzopyran-2-one
Chemical Formula: C19H16O4
Molecular Weight: 308.32
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.32 mg/liter (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
-------
CAS Registry Number: 81-81-2
Page 2 of 4
WARFARIN
SECTION II (continued)
Vapor Pressure (mmHg): Not Found
Melting Point: 322°F, 161°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Weast 1979)
Appearance and Odor: Odorless and colorless solid (*Sax 1984).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: TWA 0.1 mg/ms (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.1 mg/ms; STEL 0.3 mg/ms (*ACGIH 1980)
IDLH: 200 mg/ms (*NIOSH/OSHA 1981)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Yes (*Arena 1974)
Ingestion: Yes (*Morgan 1982)
Health Hazards (Acute, Delayed, and Chronic): It is classified as very
toxic. Probable oral lethal dose in humans is 50-500 mg/kg, between 1
teaspoon and 1 ounce for a 150 Ib. person (*Gosselin 1976). Material is an
.anticoagulant. Toxic effects other than hemorrhage are rarely seen in
humans (*Goodman 1975). Material is believed to be teratogenic in humans
(*Hayes 1982).
Medical Conditions Generally Aggravated by Exposure: Persons with a
history of blood disorders with bleeding tendencies would be expected to
be at increased risk from exposure (*NIOSH/OSHA 1981).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific - Poison B Solid) Extinguish fire
using agent suitable for type of surrounding fire. Use alcohol foam,
carbon dioxide, or dry chemical (Student 1981, p. 416).
Special Fire Fighting Procedures: (Non-Specif ic -- Poison B Solid) Wear
full protective clothing and self-contained breathing apparatus (Student
1981, p. 416).
-------
CAS Registry Number: 81-81-2
Page 3 of 4
WARFARIN
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Contact with strong oxidizers may
cause fires and explosions (*NIOSH/OSHA 1981).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Strong oxidizers (*NIOSH/OSHA 1981)
Hazardous Decomposition or Byproducts: Toxic gases and vapors (e.g.,
carbon monoxide) may be released in heating to decomposition (*NIOSH/OSHA
1981).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Material is used as a rodenticide for Norway rats and for house mice
(*SRI).
SECTION VII ~ PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material (see Section III above). Eating and smoking
should not be permitted in areas where it is handled, processed or stored.
For small spills: sweep onto paper or other suitable material. Place
in an appropriate container and burn in a safe place. Large quantities
may be destroyed by dissolving in a flammable solvent (e.g., alcohol) and
atomizing in a combustion chamber (*NIOSH/OSHA 1981).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 81-81-2
Page 4 of 4
WARFARIN
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms begin a few days or weeks after
ingestion. They include nose bleed, bleeding gums, pallor, and sometimes
hematomas around joints and on buttocks, blood in urine and feces. Later,
paralysis due to cerebral hemorrhage, and finally hemorrhagic shock and
death may occur (*Doull 1980).
Emergency and First Aid Procedures: (Non-Specific -- Coumarin Derivative
Pesticide, Solid, n.o.s.) Move victim to fresh air; call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
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CAS Registry Number: 82-66-6
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- DIPHACINONE
CAS Registry Number: 82-66-6
Synonyms: . 1,3-Indandione, 2-Diphenylacetyl-; 2-(DiphenyIacetyl)-lH-Indene-
l,3(2H)-Dione; 2-(Diphenylacetyl)Indan-l,3-Dione; 2-Diphenylacetyl-l,3-
Diketohydrindene; 2-Diphenylacetyl-l,3-Indanedione; Diandin; Didandin; Didion;
Difacione; Dipaxin; Diphacin; Diphenacin; Diphenandione; Oragulant; PID;
Promar; Ramik; Ratindan 1; Solvan; U1363; lH-Indene-l,3(2H)-Dione,
2-(Diphenylacetyl)-
Chemical Formula: C23H16O3
Molecular Weight: 340.38
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(mammal) 0.91 mg/kg (*NIOSH/RTECS 1985)
TPQ: 10/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 295-297°F, 146-147°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (*Merck 1976); 17 mg/liter
(Farm Chemicals Handbook 1984, p. C-82)
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CAS Registry Number: 82-66-6
Page 2 of 3
DIPHACINONE
SECTION II (continued)
Appearance and Odor: Pale yellow crystals (*Merck 1976); odorless (*Osol
1975)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1231)
Health Hazards (Acute, Delayed, and Chronic): This material is extremely
toxic; probable oral lethal dose in humans is 5-50 mg/kg, or between 7
drops and 1 teaspoonful for a 150-lb. person (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Many medical
conditions will be aggravated by this material (*Goodman 1980).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: The material is similar to coumarin and indandione
(*Morgan 1982). (Non-Specific -- Coumarin Derivative Pesticide, Solid,
n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam.
Large fires: water spray, fog, or foam. Move container from fire area if
you can do it without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Coumarin Derivative
Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Ventilate closed
spaces before entering them. Wear positive pressure breathing apparatus
and special protective clothing. Remove and isolate contaminated clothing
at the site (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition it emits
acrid smoke and fumes (Sax 1984, p. 1231).
NFPA Flammability Rating: Not Found -;
-------
CAS Registry Number: 82-66-6
Page 3 of 3
DIPHACINONE
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Worthing 1979)
Conditions to Avoid: Sensitive to light (*Worthing 1979)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits acrid smoke and fumes (Sax 1984, p. 1231).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Rodenticide (*Worthing 1979); and anticoagulant medication (*Merck 1976).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Do not
touch spilled material; stop leak if you can do it without risk. Use water
spray to reduce vapors. Small spills: take up with sand or other
noncombustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 55).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX — EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 82-66-6
Page 1 of 3
Emergency First Aid Treatment Guide
for
DIPHACINONE
(82-66-6)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
.authority.
Substance Characteristics:
Pure Form - Pale yellow crystals.
Odor - None.
Commercial Forms - 95% pure yellow powder, 5-mg tablets.
Use - Rodenticide.
Other Names - Diandin; Didandin; Diphacin; Diphenadione; 2-diphenylacetyl-l,3-
indanedione; Promar; Ramik; Solvan.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
vitamin K (phytonadione).
Signs and Symptoms of Acute Diphacinone Exposure:
Diphacinone is an anticoagulant. Hemorrhage is the most common effect and may
be manifested by nose bleeding, gum bleeding, bloody stools and urine,
ecchymoses (extravasations of blood into skin), and hemoptysis (coughing up of
blood). Bruising is heightened. Abdominal and flank pain are also common.
Other signs and symptoms include flushing, dizziness, hypotension (low blood
pressure), dyspnea (shortness of breath), cyanosis (blue tint to the skin and
mucous membranes), fever, and diarrhea.
Emergency Life-Support Procedures:
Acute exposure to diphacinone may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment shouldf also be worn, as necessary. Rescue vehicles
-------
EFATG
CAS Registry Number: 82-66-6
Page 2 of 3
DIPHACINONE
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to diphacinone.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to diphacinone.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas twice with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. RUSH to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
-------
EFATG
CAS Registry Number: 82-66-6
Page 3 of 3
DIPHACINONE
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of diphacinone is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of diphacinone may result in sudden onset of seizures
or loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. RUSH to a health care facility.
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CAS Registry Number: 86-50-0
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- AZINPHOS-METHYL
CAS Registry Number: 86-50-0
Synonyms: Methyl Guthion; l,2,3-Benzotriazin-4(3H)-one, 3-(Mercapto-
methyl)-, O,O-Dimethyl Phosphorodithioate; 3-(Mercaptomethyl)-1,2,3-
Benzotriazin-4(3H)-one O,O- Dimethyl Phosphorodithioate S-Ester; Bay 17147; Bay
9027; Bayer 17147; Bayer 9027; Benzotriazine Derivative of a Methyl
Dithiophosphate; Benzotriazinedithiophosphoric Acid Dimethoxy Ester; Carfene;
Cotneon; Cotnion; Cotnion Methyl; Crysthion 2L; Crysthyon; DBD;
Dimethyldithiophosphoric Acid N-Methylbenzazimide Ester; ENT 23,233; Gothnion;
Gusathion; Gusathion 25; Gusathion K; Gusathion M; Gusathion Methyl;
Gusathion-20; Guthion; Methyl Azinphos; Methyl Gusathion; Metiltriazotion;
N-Methylbenzazimide, Dimethyldithiophosphoric Acid Ester; NCI-C00066;
O,O-Dimethyl S-(3,4-Dihydro-4-Keto-l,2,3-Benzotriazinyl-3-Methyl)
Dithiophosphate; O,O-Dimethyl S-(4-Oxo-l,2,3-Benzotriazino(3)-Methyl)
Thiothionophosphate; O,O-Dimethyl S-(4-Oxo-3H-l,2,3-Benzotriazine-3-Methyl)
Phosphorodithioate; O,O-Dimethyl S-(4-Oxobenzotriazino-3-Methyl)
Phosphorodithioate; O,O-Dimethyl S-4-Oxo-l,2,3-Benzotriazin-3(4H)-ylmethyl
Phosphorodithioate; O,O-Dimethyl-S-(l,2,3-Benzotriazinyl-4-Keto)Methyl
Phosphorodithioate; O,O-Dimethyl-S-(Benzaziminomethyl) Dithiophosphate;
Phosphorodithioic Acid, O,O-Dimethyl Ester, S-Ester With 3-(Mercaptomethyl)-
l,2,3-Benzotriazin-4(3H)-one; Phosphorodithioic Acid, O,O-Dimethyl S-((4-Oxo-
l,2,3-Benzotriazin-3(4H)-yl)Methyl) Ester; Phosphorodithioic Acid, O,O-
Dimethyl S-(4-Oxo-l,2,3-Benzotriazin-3(4H)-ylmethyl)Ester; R 1582;
S-(3,4-Dihydro-4-Oxo-l,2,3-Benzotriazin-3-ylmethyl) O,O-Dimethyl
Phosphorodithioate; S-(3,4-Dihydro-4-Oxo-Benzo(alpha)-(l,2,3-Triazin-3-yl
Methyl) O,O-Dimethyl Phosphorodithioate
Chemical Formula: C10H12N3O3PS2
Molecular Weight: 317.34
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC60 inhalation
(rat) 0.069 mg/liter/1 hour (*NIOSH/RTECS 1985)
TPQ: 10/10,000 (pounds)
RQ: 1 (pounds)
Section 313 Listed (Yes or No): No
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CAS Registry Number: 86-50-0
Page 2 of 4
AZINPHOS-METHYL
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 1.44 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): Negligible at 20°C (*Worthing 1979)
Melting Point: 163-165°F; 73-74°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 33 ppm at room temperature (*Worthing 1979)
Appearance and Odor: White crystals (*Worthing 1979) or brown waxy solid
(*Hawley 1981)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.2 mg/m3 (NIOSH 1987, p.54)
ACGIH TLV: TWA 0.2 mg/m3 (ACGIH 1986-87, p. 10)
IDLH: 5 mg/m3 (NIOSH 1987, p.54)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Hayes 1982, p. 358)
Skin: Yes (Hayes 1982, p. 358)
Ingestion: Yes (Hayes 1982, p. 358)
Health Hazards (Acute, Delayed, and Chronic): Acute: extremely toxic.
Probable oral lethal dose in humans is 5-50 mg/kg, or between 7 drops and 1
teaspoon for a 70 kg (150 Ib.) person. A potent ch'olinesterase inhibitor
which can cause death (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide, water
spray, or foam. Large fires: water spray, fog, or foam (*DOT 1984).
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CAS Registry Number: 86-50-0
Page 3 of 4
AZINPHOS-METHYL
SECTION IV (continued)
Special Fire Fighting Procedures: Move containers from fire area if you
can do it without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (*DOT 1984).
Unusual Fire and Explosion Hazards: Some of the formulations may burn,
but none of them ignite easily. Container may explode in the heat of the
fire (*DOT 1984).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Unstable at temperatures above 390°F (200°C)
(*Worthing 1979)
Stable:
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Rapidly hydrolyzed by cold alkali
or cold acid (*Worthing 1979)
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Insecticide for control of pests on a wide range of crops. Used to control
boll weevil on cotton, and for control of insects on deciduous fruits,
nuts, vegetables, field crops, citrus, and for non-agricultural use (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Remove and isolate contaminated clothing at the site (*DOT
1984). Do not touch spilled material. Stop leak if you can do so without
risk. Use water spray to reduce vapors. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (*DOT 1984).
-------
CAS Registry Number: 86-50-0
Page 4 of 4
AZINPHOS-METHYL
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 86-50-0
Page 1 of 3
Emergency First Aid Treatment Guide
for
AZINPHOS-METHYL
(86-50-0)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - White crystals.
Commercial Forms - Waxy brown solid, 50% wettable powder or water emulsion.
Use - Insecticide.
Other Names - l,2,3-Benzotriazin-4(3H)-one, 3-(mercaptomethyl)-, O,O-dimethyl
phosphorodithioate; Carfene; Cotneon; Cotnion-Methyl; Crysthyon; Gusathion M;
Guthion.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
atropine, pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Azinphos-Methyl Exposure:
Warning: Effects may be delayed up to 12 hours. Caution is advised.
Note: Azinphos-methyl is a cholinesterase inhibitor.
Acute exposure to azinphos-methyl may produce the following signs and symptoms:
pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and
profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may
also occur. The heart rate may decrease following oral exposure or increase
following dermal exposure. Chest pain may be noted. Hypotension (low blood
pressure) may be observed, although hypertension (high blood pressure) is not
uncommon. Respiratory symptoms include dyspnea (shortness of breath),
respiratory depression, and respiratory paralysis. Psychosis may occur.
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CAS Registry Number: 86-50-0
Page 2 of 3
AZINPHOS-METHYL
Emergency Life-Support Procedures:
Acute exposure to azinphos-methyl may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to azinphos-methyl.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to azinphos-methyl.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least IS minutes.
5. Wash exposed skin areas three times with soap and water.,
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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CAS Registry Number: 86-50-0
Page 3 of 3
AZINPHOS-METHYL
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of azinphos-methyl is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of azinphos-methyl may result in sudden onset of
seizures or loss of consciousness. Syrup of Ipecac should be
administered only if victims are alert, have an active gag-reflex, and
show no signs of impending seizure or coma. If ANY uncertainty exists,
proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
-------
CAS Registry Number: 86-88-4
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ANTU
CAS Registry Number: 86-88-4
Synonyms: Urea, l-(l-Naphthyl)-2-Thio-; alpha-Naphthylthiourea;
l-(l-Naphthyl)-2-Thiourea; l-(l-Naphthyl)Thiourea; 1-Naphthyl Thiourea;
1-Naphthylthiourea; alpha-Naphthothiourea; alpha-Naphthylthiocarbamide;
alphanaphthyl Thiourea; Alrato; Anturat; Bantu; Chemical 109; Dirax; Kill
Kantz; Kripid; Krysid; Krysid PI; N-(l-Naphthyl)-2-Thiourea;
N-1-Naphthylthiourea; Naphtox; Rat-Tu; Rattrack; Smeesana; Thiourea,
1-NaphthalenyI-; U-5227; USAF EK-P-5976
Chemical Formula: CnH10N2S
Molecular Weight: 202.23
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (dog)
0.38 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): 0 at 25°C (*Sax 1975)
Melting Point: 388°F, 198°C (*Merck 1976)
Vapor Density (AIR=1): 6.99 (*NIH EPA, OHM/TADS 1984)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.6 g/L water at 25°C (*Merck 1976)
-------
CAS Registry Number: 86-88-4
Page 2 of 3
ANTU
*
SECTION II (continued)
Appearance and Odor: White crystal or powder; technical product is gray
powder (*Clarke 1981). No odor (*ACGIH 1980); bitter taste (*Merck 1976).
i
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.3 mg/m8 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.3 mg/ms (ACGIH 1986-87, p.10)
IDLH: 100 mg/ms (*NIH EPA, OHM/TADS 1984)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Moderately toxic: probable
oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or 1
Ib.) for 150 Ib. person (*Gosselin 1976). Chronic sublethal exposure may
cause antithyroid activity. Can produce hyperglycemia of three times
normal in three hours (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: People with chronic
respiratory disease or liver disease may be especially at risk (*NIOSH/OSHA
1981).
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): May burn but will not ignite readily (*DOT
1984)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam (*DOT 1984).
Special Fire Fighting Procedures: Stay upwind, and out of low areas.
Wear self-contained breathing apparatus and full protective clothing (*DOT
1984).
Unusual Fire and Explosion Hazards: Emits toxic fumes upon decomposition
(*Sax 1975).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 86-88-4
Page 3 of 3
ANTU
SECTION V -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Worthing 1979)
Conditions to Avoid: Decomposing heat (*Sax 1975)
Incompatibility (Materials to Avoid): It reacts with silver nitrate and
strong oxidizers (*Sax 1975)
Hazardous Decomposition or Byproducts: When heated it emits sulfur
dioxide, oxides of nitrogen, and carbon monoxide (*NIOSH/OSHA 1981).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI ~ USE INFORMATION
This material was used primarily as a rodenticide for control of adult
Norway rats. It is not produced commercially in the U.S. (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section III above). Do not touch
spilled material, stay upwind, keep out of low areas, deny entry
(*DOT 1984).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms include seizures, pulmonary
edema and dermal irritation (*Rumack 1975 to Present). Ingestion may cause
vomiting, shortness of breath, and bluish discoloration of the skin
(*NIOSH/OSHA 1981).
Emergency and First Aid Procedures: Move victim to fresh air. Treat
pulmonary edema with positive pressure oxygen (*Rumack 1975 to Present).
Immediately flush with fresh water for at least 15 minutes in case of skin
or eye contact (*Gosselin 1976).
-------
CAS Registry Number: 144-49-0
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDE TY -- FLUOROACETIC ACID
CAS Registry Ni? •-: 144-49-0
Synonyms: Ace d, Fluoro-; 2-Fluoroacetic Acid; alpha-Fluoroacetic Acid;
Cymonic Acid; , uoroethanoic Acid; Gifblaar Poison; HFA; MFA;
Monofluoroacetic n
Chemical Formula: C2HSFO2
Molecular Weight: 78.04
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(guinea pig) 0.468 mg/kg (*NIOSH/RTECS 1985)
TPQ: 10/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: 329°F, 165°C (*Weast 1979)
Specific Gravity (H2O=1): 1.3693 at 97°F, 36°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: 95.4°F, 35.2°C (*Weast 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (Weast 1983, p. 597)
Appearance and Odor: Colorless crystals (*Hawley 1977)
-------
CAS Registry Number: 144-49-0
Page 2 of 4
FLUOROACETIC ACID
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.05 mg/ms (for sodium salt) (OSHA 1984, p. 663)
ACGIH TLV: TWA 0.05 mg/ms; STEL 0.15 mg/ms (for sodium salt) (*ACGIH
1980)
IDLH: Not Found
Other Limits Recommended: IDLH for sodium salt: 5 mg/ms (NIOSH/OSHA
1978, p. 166).
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): This material is very
toxic; ingestion of small quantities may cause death (*Sax 1975).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV ~ FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Burns (*Merck 1976)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: use dry chemical, carbon dioxide,
water spray, or foam. For large fires, use water spray, fog, or foam (DOT
1984, Guide 59).
Special Fire Fighting Procedures: Stay upwind; keep out of low areas.
Wear self-contained, positive pressure breathing apparatus and full
protective clothing. Move container from fire area. Cool containers that
are exposed to flames with water from the side until well after fire is out
(DOT 1984, Guide 59).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits highly toxic fumes of fluorine containing compounds (*Sax 1979).
Some of these materials may burn but none ignite readily. These materials
may ignite combustibles (wood, paper, oil, etc.) (DOT 1984, Guide 59).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Encyc Occupat Health and Safety 1971)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
-------
CAS Registry Number: 144-49-0
Page 3 of 4
FLUOROACETIC ACID
SECTION V (continued)
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits highl- xic fumes of fluorine containing compounds (*Sax 1979).
Hazardous 1 merization: May Occur: Not Found
May Not Occur: Not Found
Conditn to Avoid: Not Found
SECTION VI - " INFORMATION
Rodenticide (Hawley 1981, p. 470). The sodium salt of this material is
used as a rodent poison (*Patty 1963).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material. Stop leak if you can do so without risk.
Stay upwind; keep out of low areas. Use water spray to reduce vapors.
For small spills, take up with sand or other noncombustible absorbent
material and place into containers for later disposal. For large spills,
dike spill for later disposal (DOT 1984, Guide 59).
SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED**
Butyl/Neoprene GOOD/LIMITED**
CPE GOOD/LIMITED**
Neoprene GOOD/LIMITED**
Nitrile GOOD/LIMITED**
PE POOR/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
-------
CAS Registry Number: 144-49
Page 4 of 4
FLUOROACETIC ACID
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: The major symptoms of fluoroacetic acid
poisoning include severe epileptiform convulsions alternating with coma and
depression; death may result from asphyxia during convulsion or from
respiratory failure. Cardiac irregularities, such as ventricular
fibrillation and sudden cardiac arrest, nausea, vomiting, excessive
salivation, numbness, tingling sensations, epigastric pain, mental
apprehension, muscular twitching, low blood pressure, and blurred vision
may also occur (*Encyc Occupat Health and Safety 1971).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature (DOT 1984, Guide 59).
-------
CAS Registry Number: 149-74-6
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDE HTY - DICHLOROMETHYLPHENYLSILANE
CAS Registry Ni- ? ?r: 149-74-6
Synonyms: Met >henyldichlorosilane; Phenylmethyldichlorosilane; Silane,
Dichloromethylp. yl-
Chemical Formula: C7H8Cl2Si
Molecular Weight: 191.14
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LClow inhalation
(mouse) 0.2 mg/liter/2 hours (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 401°F, 205°C (Hawley 1981, p. 688)
Specific Gravity (H2O=1): 1.19 (*Hawley 1977)
Vapor Pressure (mmHg): 1.0 at 35.7°C (Perry 1984, p. 3-54)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Colorless liquid (*Hawley 1977)
-------
CAS Registry Number: 149-74-6
i*age 2 of 3
DICHLOROMETHYLPHENYLSILANE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): The chemical is toxic and
is an irritant (*Hawley 1977). Contact may cause burns to the skin and
eyes (DOT 1984, Guide 29).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 83°F (28°C) (*Hawley 1977) (SUSPECT)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon dioxide,
water spray or foam. For large fires, use water spray, fog, or foam (DOT
1984, Guide 29).
Special Fire Fighting Procedures: Isolate for 1/2 mile in all directions
if tank car or truck is involved in a fire. Wear self-contained (positive
pressure) breathing apparatus with full protective clothing. Do not get
water inside container (DOT 1984, Guide 29).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of chlorine-containing compounds (Sax 1984, p. 951).
Flammable/combustible material; may be ignited by heat, sparks, or flames.
Vapors may travel to a source of ignition and flash back. Container may
explode in heat of fire. Vapor explosion hazard indoors, outdoors or in
sewers. Runoff to sewer may create fire or explosion hazard. Fire may
produce irritating or poisonous gases (DOT 1984, Guide 29).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found >
-------
CAS Registry Number: 149-74-6
Page 3 of 3
DICHLOROMETHYLPHENYLSILANE
SECTION V (continued)
Incompatibility (Materials to Avoid): Reacts strongly with oxidizing
materials (*F- 'ey 1977)
Hazardous i rnposition or Byproducts: When heated to decomposition, it
emits toxic i ;s of chlorine-containing compounds (Sax 1984, p. 951).
Hazardous P .^erization: May Occur: Not Found
May Not Occur: Not Found
Conditi to A>oid: Not Found
SECTION VI - USE INFORMATION
Used in the manufacture of silicones ("Hawley 1977); and as a chemical
intermediate for silicone fluids, resins and elastomers (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away. Stay upwind. Stay out of low areas.
Shut off ignition sources; no flares, smoking or flames in hazard
area. Do not touch spilled material; stop leak if you can do so
without risk. Use water spray to reduce vapors; do not get water
inside container. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 29).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material;
immediately flush skin or eyes with running water for at least 15 minutes.
Keep victim quiet and maintain normal body temperature (DOT 1984, Guide
29).
-------
CAS Registry Number: 151-38-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - METHOXYETHYLMERCURIC ACETATE
CAS Registry Number: 151-38-2
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 657) Mercury,
(Acetato)(2-Methoxyethvi -; Acetato(2-Methoxyethyl)Mercury; Landisan; MeEHg;
MEMA; Mercuran; Mercury, Acetoxy(2-Methoxyethyl)-; Radosan; Methoxyethyl
Mercuric Acetate
(Farm Chemicals Handbook 1984, p. CHS) Panogen
Chemical Formula: C5H10HgOs
Molecular Weight: 318.74
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (rat)
16 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): In Mercury Compounds category
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (Sax 1984, p. 1776)
Appearance and Odor: Crystals (Sax 1984, p. 1776)
-------
CAS Registry Number: 151-38-,.
Page 2 of 4
METHOXYETHYLMERCURIC ACETATE
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: (Mercury alkyl compounds) TWA 0.01 mg/m3, as mercury; Ceiling 40
mg/ms, as mercury (NIOSH 1987, p. 152)
ACGIH TLV: (Mercury alkyl compounds) TWA 0.01 mg/ms, as mercury; STEL 30
mg/ms, as mercury (skin) (ACGIH 1986-87, p. 22)
IDLH: (Mercury alkyl compounds) 10 mg/ms, as mercury (NIOSH 1987, p. 152)
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Encyc Occupat Health and Safety
1983, p. 1337)
Skin: Yes (Non-Specific — Mercury Compounds)
(Hayes 1982, pp. 15-16)
Ingestion: Yes (Encyc Occupat Health and Safety
1983, p. 1337)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic (Hawley 1981,
p. 664). Target organs are brain and central nervous system (Hayes 1982,
pp. 18-19). Inhalation can cause lung damage; ingestion can cause kidney
damage. Women of childbearing age should avoid exposure (Encyc Occupat
Health and Safety 1983, p. 1337).
Medical Conditions Generally Aggravated by Exposure: Women of
childbearing age and persons with eczema, renal or neurological disorders
should not be exposed to mercurials (Encyc Occupat Health and Safety, 1983,
p. 1337).
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This is an alkyl mercury pesticide (Hayes 1982, p.
20). Small fires: dry chemical, carbon dioxide, water spray, or foam.
Large fires: water spray, fog, or foam. Move container from fire area if
you can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material. Fire may
produce irritating or poisonous gases. Runoff from fire control water may
give off poisonous gases. Runoff from fire control or dilution water may
cause pollution (DOT 1984, Guide 55).
Special Fire Fighting Procedures: This* is an alkyl mercury pesticide
(Hayes 1982, p. 20). Keep unnecessary people away; isolate hazard area and
deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Remove and isolate contaminated clothing at
the site. If water pollution occurs, notify appropriate authorites (DOT
1984, Guide 55).
-------
CAS Registry Number: 151-38-2
Page 3 of 4
METHOXYETHYLMERCURIC ACETATE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of mercury (Sax 1984, p. 1776). This material may burn
but does not ignite readily. Container may explode in heat of fire (DOT
1984, Guide 55).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Uns^ble: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits toxic fumes of mercury (Sax 1984, p. 1776).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Used as a pesticide in seed treatment for cotton and small grains. It is
no longer approved for this use (Farm Chemicals Handbook 1984, pp.
C144-148). It exhibits high fungicidal activity against leaf stripe of
barley, stinking smut of wheat, snow mold of rye; against seedling diseases
in beets and legumes, and for dressing "seed" potatoes, bulbs, and tubers
(Buchel 1983, pp. 250-51). Not registered as a pesticide in the U.S.
(USEPA/Pesticide Index 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
This is an alkyl mercury pesticide (Hayes 1982, p. 20). Do not touch
spilled material; stop leak if you can do so without risk. Use water spray
to reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Small dry
spills: with clean shovel place material into clean, dry container and
cover; move containers from spill area. Large spills: dike far ahead of
spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number:
Page 4 of 4
METHOXYETHYLMERCURIC ACETATE
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATIC.
Signs and Symptoms of Exposure: This is an alkyl mercu.y pesticide.
Patients complain of headache, paresthesia of tongue, lips, fingers, and
toes, a metallic taste in mouth, gastrointestinal disturbances, gas, and
diarrh.ea. Nervous system symptoms may appear first after a relatively
slight exposure or have a latency period of several weeks. These symptoms
include fine tremors of extended hands, loss of side vision, slight loss of
coordination, loss of coordination of speech, writing and gait.
Uncoordination may progress to loss of ability to control voluntary
movements. Irritability and bad temper may progress to mania. Stupor or
coma may develop. Blisters or dermatitis may be present on skin. Symptoms
persist for years even in cases of mild exposure (Hayes 1982, pp. 20-21).
Emergency and First Aid Procedures: This is an alkyl mercury pesticide
(Hayes 1982, p. 20). Move victim to fresh air; call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
COMMENTS
Sources searched but no information found:
Weast 1979
ACGIH 1983
NIOSH/OSHA 1978
Weiss 1980
Merck 1983
Clayton and Clayton 1981-82
Student 1981
-------
CAS Registry Number: 151-50-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - POTASSIUM CYANIDE
CAS Registry Number: 151-50-8
Synonyms: Cyanide of Potassium; Hydrocyanic Acid, Potassium Salt; Potassium
Cyanide (KCN)
Chemical Formula: KCN
Molecular Weight: 65.11
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD60 oral
(rabbit) 5 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 1.52 at 16°C (Weast 1978, p. B150)
Vapor Pressure (mmHg): Not Found
Melting Point: 1173°F, 634°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in 2 parts cold water or 1 part boiling
water (*Merck 1976)
Appearance and Odor: White granular powder or lumps with faint odor of
bitter almonds (*Merck 1976,* Hawley 1977)
-------
CAS Registry Number: 151-50-8
Page 2 of 4
POTASSIUM CYANIDE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 5 mg/ms as cyanide (*NIOSH/RTECS 1985)
ACGIH TLV: (Cyanides) TWA 5 mg/ms as cyanide (skin) (ACGIH 1986-87, p. 14)
IDLH: 50 mg/ms (NIOSH/OSHA 1978, p. 74)
Other Limits Recommended: NIOSH Occupational Exposure Recommended Standard
-- Air Ceiling 5 mg/ms as cyanide, 10 minutes (*NIOSH/RTECS 1985)
Routes of Entry: Inhalation: Not Found
Skin: Yes (*Merck 1976)
Ingestion: Yes (*Merck 1976)
Health Hazards (Acute, Delayed, and Chronic): It is classified as super
toxic. Probable oral lethal dose in humans is less than 5 mg/kg or less
than a taste (7 drops) for a 150 Ib. person (*Gosselin 1976). It is an eye
and skin irritant (*Grant 1974, *Encyc Occupat Health and Safety 1971)..
Poisonous in very small quantities; a taste is lethal (*Gosselin 1984).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not flammable (*NFPA 1978)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Water may be used on fire in an area containing
potassium cyanide (*NFPA 1978). Extinguish with dry chemical, carbon
dioxide, water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Wear full protective clothing (*NFPA
1978). Wear positive pressure breathing apparatus and special protective
clothing. Move container from fire area if you can do it without risk.
Fight fire from maximum distance. Dike fire control water for later
disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Contact with acid releases highly
flammable hydrogen cyanide gas (*NFPA 1978). Moisture may cause this
material to volatilize as hydrogen cyanide (*Peer Review Committee).
NFPA Flammability Rating: 0
SECTION V -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 766)
Conditions to Avoid: Avoid contact with acids (see Section *V above)
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CAS Registry Number: 151-50-8
Page 3 of 4
POTASSIUM CYANIDE
SECTION V (continued)
Incompatibility (Materials to Avoid): Reacts with acids to produce
hydrogen cyanide gas (*NFPA 1978). Reacts with strong oxidizers such as
nitrates and chlorates (NIOSH/OSHA 1978, p. 74); nitrogen trichloride;
perchloryl fluoride; sodium nitrate; acids; alkaloids; chloral hydrate;
iodine (Sax 1984, p. 2273).
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits very toxic fumes of cyanide and nitrogen oxides (Sax 1984, p. 2273).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Potassium cyanide is used for electroplating, steel hardening, extraction
of gold and silver from ores, manufacture of some chemicals, and fumigation
(*Encyc Occupat Health and Safety 1971).
SECTION VII ~ PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid water. Cover spilled material with alkali or sodium thiosulfate
(*Rumack 1975 to Present). Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Do not touch spilled
material; stop leak if you can do it without risk. Use water spray to
reduce vapors. Small spills: take up with sand or other noncombustible
absorbent material and place into containers for later disposal. Small dry
spills: with clean shovel place materials into clean, dry container and
cover; move containers from spill area. Large spills: dike far ahead of
spill for later disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
PVC GOOD/LIMITED*
*Based on qualitative performance information.
**Based on a chemical analog.
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CAS Registry Number: 151-50-8
Page 4 of 4
POTASSIUM CYANIDE
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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CAS Registry Number: 151-50-8
Page 1 of 4
Emergency First Aid Treatment Guide
for
POTASSIUM CYANIDE
(151-50-8)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Caution: Potassium cyanide toxicity can occur via ingestion, dermal/eye
contact, or inhalation; death may occur within minutes. IMMEDIATELY begin
administering 100% oxygen and RUSH victims to a health care facility!
Substance Characteristics:
Pure Forms - White, amorphous, deliquescent lumps or crystalline mass.
Odor - Faint odor of bitter almonds.
Commercial Forms - Pure form, solution, or reagent in 25- and 100-pound drums.
Uses - Electroplating, steel hardening, gold and silver extraction, fumigation,
insecticide, chemical intermediate.
Materials to Avoid - Acids.
Caution: Avoid sources of extreme heat including fire. Potassium cyanide will
emit toxic cyanide and nitrogen oxide fumes when heated to decomposition.
Other Names - Cyanide of potassium; hydrocyanic acid, potassium salt.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline
cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote
kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium
bicarbonate, diazepam, phenytoin.
Signs and Symptoms of Acute Potassium Cyanide Exposure:
Warning: Effects may be delayed. Caution is advised. Vital signs should be
monitored closely. Heart palpitation may occur within minutes after exposure.
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EFATG
CAS Registry Number: 151-50-8
Page 2 of 4
POTASSIUM CYANIDE
Signs and symptoms of acute exposure to potassium cyanide may include
hypertension (high blood pressure) and tachycardia (rapid heart rate), followed
by hypotension (low blood pressure) and bradycardia (slow heart rate). Cardiac
arrhythmias and other cardiac abnormalities are common. Cyanosis (blue tint to
the skin and mucous membranes), and cherry-red or bloody mucous membranes may
appear.
Tachypnea (rapid respiratory rate) may be followed by respiratory depression.
Lung hemorrhage and pulmonary edema may occur. Headache, vertigo (dizziness),
agitation, and giddiness may precede combative behavior, convulsions,
paralysis, protruding eyeballs, dilated and unreactive pupils, and coma.
Potassium cyanide is irritating to the skin, eyes, and mucous membranes.
Lacrimation (tearing) and a burning sensation of the mouth and throat are
common. Salivation, nausea, and vomiting may also occur.
Emergency Life-Support Procedures:
Acute exposure to potassium cyanide may require decontamination and life
support for the victims. All exposed persons should be transported to a health
care facility as quickly as possible. Emergency personnel should wear
protective clothing appropriate to the type and degree of contamination. Air-
purifying or supplied-air respiratory equipment should also be worn, as
necessary. Rescue vehicles should carry supplies such as plastic sheeting and
disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to potassium cyanide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen mask. Direct oral contact with potassium cyanide-
contaminated persons or their gastric contents can result in self-
poisoning.
3. RUSH to a health care facility!
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
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EFATG
CAS Registry Number: 151-50-8
Page 3 of 4
POTASSIUM CYANIDE
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to potassium cyanide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
forced-oxygen ma$k. Direct oral contact with potassium cyanide-
contaminated persons or their gastric contents can result in self-
poisoning.
3. RUSH to a health care facility!
4. Remove contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
6. Wash exposed skin areas twice with soap and water.
7. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use a
•forced-oxygen mask. Direct oral contact with potassium cyanide-
contaminated persons or their gastric contents can result in self-
poisoning.
2. RUSH to a health care facility!
3. DO NOT induce vomiting. Ipecac is not recommended for ingestion of
potassium cyanide.
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
5. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
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CFATG
CAS Registry Number: 151-50-8
Page 4 of 4
POTASSIUM CYANIDE
6. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
-------
CAS Registry Number: 151-56-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ETHYLENEIMINE
CAS Registry Number: 151-56-4
Synonyms: (N1OSH/RTECS 1983 Synonyms, Volume 2, p. 291) Aminoethylene;
Azacyclopropane; Azirane; Aziridine; IH-Azirine, dihydro-; Dihydroazirene;
Dimethyleneimine; Dimethylenimine; El; Ethylenimine; ENT-50324, Ethylimine.
Chemical Formula: C2H5N
Molecular Weight: 43.07
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.1 mg/liter/2 hours (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds) (statutory); 1 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 131-133°F, 55-56°C (Clayton and Clayton 1981-82,
p. 2673)
Specific Gravity (H2O=1): 0.8321 at 20°C (Clayton and Clayton 1981-82, p.
2673)
Vapor Pressure (mmHg): 160 at 20°C (Clayton and Clayton 1981-82,
p. 2673)
Melting Point: -98°F, -72°C (Freezing Point) (Clayton and Clayton
1981-82, p. 2673)
Vapor Density (AIR=1): 1.48 (Clayton and Clayton 1981-82, p. 2673)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (Merck 1983, p. 3744)
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CAS Registry Number: 151-56-4
iage 2 of 4
ETHYLENEIMINE
SECTION II (continued)
Appearance and Odor: Colorless, mobile fluid with a strong ammoniacal
odor (Clayton and Clayton 1981-82, p. 2673; Merck 1983, p. 3744)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Occupational carcinogen; no permissible exposure limit (NIOSH
1987, Appendix C)
ACGIH TLV: TWA O.Sppm (1.0 mg/ms) (skin) (ACGIH 1986-87, p. 19)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 443)
Skin: Yes (Weiss 1980, p. 443)
Ingestion: Yes (Weiss 1980, p. 443)
Health Hazards (Acute, Delayed, and Chronic): Ethyleneimine is classified
as extremely toxic with a probable oral lethal dose of 5-50 mg/kg which is
approximately 7 drops to 1 teaspoonful for a 70 kg (150 Ib.) person
(*Gosselin 1976). Ethyleneimine gives inadequate warning when
over-exposure is by inhalation or skin absorption. It is a severe
blistering agent, causing third degree chemical burns of the skin. Also,
it has a corrosive effect on mucous membranes and may cause scarring of the
esophagus. It is corrosive to eye tissue and may cause permanent corneal
opacity and conjunctival scarring (Weiss 1980, p. 443). Severe exposure
may result in overwhelming pulmonary edema. Renal damage has been
described (Gosselin 1984, p. H-207). Hemorrhagic congestion of all
internal organs has been observed (Clayton and Clayton 1981-82, p. 2674).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 12°F (CC) (NFPA 1984, p. 325M-51)
Flammable Limits:
LEL: 3.6% (NFPA 1984, p. 325M-51)
UEL: 46% (NFPA 1984, p. 325M-51)
Extinguishing Methods: Dry chemical, alcohol foam, or carbon dioxide are
useful for small fires. For large fires: water spray, fog or foam (DOT
1984, Guide 30).
Special Fire Fighting Procedures: Do not extinguish fire unless flow can
be stopped; use water in flooding quantities as a fog. Solid streams of
water may be ineffective. Apply water from as far a distance as possible
(Student 1981, p. 236). If tank car or truck is involved in fire, isolate
the surrounding area in a 1/2 mile radius (DOT 1984, Guide 30).
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CAS Registry Number: 151-56-4
Page 3 of 4
ETHYLENEIMINE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Irritating vapors are generated when
heated. Vapor is heavier than air and may travel a considerable distance
to a source of ignition and flash back. May polymerize in fires with
evolution of heat and container rupture (Weiss 1980, p. 443). Runoff to
sewer may create fire or explosion hazard (DOT 1984, Guide 30).
Ethyleneimine vapors are not inhibited and may form polymers in vents or
flame arresters, r , alting in stopping of the vents (*NFPA 1978).
NFPA Flammabilu; Rating: 3
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 443)
Conditions to Avoid: If heated under pressure, instability may result
(Weiss 1980, p. 443).
Incompatibility (Materials to Avoid): Acids (Weiss 1980, p. 443); sodium
hypochlorite (*Bretherick 1979).
Hazardous Decomposition or Byproducts: Toxic oxides of nitrogen are
produced during combustion (Student 1981, p. 236). Upon treatment with
sodium hypochlorite, it gives off the explosive compound 1-chloroazidine
(*Bretherick 1979).
Hazardous Polymerization: May Occur: Yes (Merck 1983, p. 551)
May Not Occur:
Conditions to Avoid: Avoid contact with silver or aluminum.
Explosive polymerization may occur upon contact with acids (Weiss 1980,
p. 443). Polymerization is catalyzed by carbon dioxide (*Bretherick
1979).
SECTION VI - USE INFORMATION
Products of polymerization of ethyleneimine are used in the paper industry
and as flocculation aids (*Encyc Occupat Health and Safety 1971). Used in
textile chemicals, adhesives, binders, petroleum refining chemicals, fuels
and lubricants, coating resins, varnishes, lacquers, agricultural
chemicals, cosmetics, ion exchange resins, photographic chemicals and
surfactants (*Clayton and Clayton 1981-82).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors. Keep upwind. Avoid bodily contact with the
material. Do not handle broken packages without protective equipment. Wash
away any material which may have contacted the body with copious amounts of
-------
C .5 Registry Number: 151-56-4
I age 4 of 4
ETHYLENEIMINE
SECTION VII (continued)
water or soap and water (Student 1981, p. 237). ^Keep unnecessary people
away, isolate hazard area and deny entry. Stay upwind, keep out of low
areas (DOT 1984, Guide 30).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/LIMITED
Neoprene POOR/MANY
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms include tearing and burning of
the eyes, sore throat, nausea, vomiting, coughing (may persist for weeks or
months) and a slow healing dermatitis due to severe blistering (Gosselin
1984, p. 11-207; Weiss 1980, p. 443).
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Remove and isolate contaminated clothing and shoes at the site.
In case of contact with ethyleneimine, immediately flush skin or eyes with
running water for at least 15 minutes (DOT 1984, Guide 30).
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CAS Registry Number: 152-16-9
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- DIPHOSPHORAMIDE, OCTAMETHYL-
CAS Registry Number: 152-16-9
Synonyms: Pyrophosphoramide, Octamethyl-; Bis(bisdimethylaminophosphonous)
anhydride; Bis(dimethylamino)phosphoric anhydride; Bis-N,N,N',N'-tetramethyl-
phosphorodiamidic anhydride; Lethalaire G-59; Octamethyl pyrophosphortetramide;
Octamethyl tetramido pyrophosphate; Octamethyldiphosphoramide; Octamethyl-
pyrophosphoramide; Octamethylpyrophosphoric acid tetramide; OMPA; Ompacide;
Ompatox; Ompax; Pestox III; Schradan; Pyrophosphoric acid octamethyltetraamide;
Pyrophosphoryltetrakisdimethylamide; Scharadan; Systam; Systophos; Sytam;
Tetrakisdimethylaminophosphonous anhydride
Chemical Formula: C8H24N4P2OS
Molecular Weight: 286.26
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDSO oral (rat)
5 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 248-257°F, 120-125°C at 0.5 mmHg (*Merck 1976)
Specific Gravity (H2O=1): 1.09 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 0.001 at 25°C (*Worthing 1979)
Melting Point: 57-68°F, 14-20°C (*Worthing 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (*Merck 1976)
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CAS Registry Number: 152-16-9
Page 2 of 4
DIPHOSPHORAMIDE, OCTAMETHYL-
SECTION II (continued)
Appearance and Odor: Viscous liquid (*Merck 1976); dark brown viscous
liquid (*Worthing 1979).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Maximum permissible atmospheric concentration
of this compound in work places is estimated to be 0.5 mg/ms (*Clarke
1975).
Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and Safety
1971)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic; probable
oral lethal dose in humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful
for a 150 Ib. person (*Gosselin 1976). It is highly toxic when inhaled
(*Encyc Occupat Health and Safety 1971). Material is a cholinesterase
inhibitor (*Hayes, 1975). It is similar in action to other
organophosphorous pesticides in its toxicity. It is slightly less toxic
than parathion (*Gosselin 1976). Gastrointestinal, neurologic and
respiratory symptoms may accompany poisoning with this material. High
doses may cause a toxic psychosis similar to acute alcoholism (*Rumack 1975
to Present).
Medical Conditions Generally Aggravated by Exposure: Persons taking
phenobarbital and phenaglycodol together, glutethimide, chlorpromazine
hydrochloride, or meprobamate may be at greater risk. These drugs appear
to enhance the toxicity of the material markedly (*Kato 1967).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorus Liquid
Pesticides) Do not extinguish fire unless flow can be stopped. Use water
in flooding quantities as fog. Solid streams of water may be ineffective.
Cool all affected containers with flooding quantities of water. Apply
water from as far a distance as possible. Use alcohol foam, carbon
dioxide, or dry chemical (*Student 1981).
Special Fire Fighting Procedures: Not Found
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CAS Registry Number: 152-16-9
Page 3 of 4
DIPHOSPHORAMIDE, OCTAMETHYL-
SECTION IV (continued)
Unusual Fire and Explosion Hazards: When heated to decomposition, it can
emit highly toxic fumes of oxides of phosphorus (*Sax 1979).
NFPA Flammability Rating: Not Found
SECTION V ~ REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Worthing 1979)
Conditions to Avoid: Hydrolyzed under acid conditions to
dimethylamine and orthophosphoric acid (*Worthing 1979)
Incompatibility (Materials to Avoid): Decomposes when mixed with acid
(*Worthing 1979).
Hazardous Decomposition or Byproducts: Decomposes when mixed with acid
(*Worthing 1979). Emits highly toxic fumes of oxides of phosphorous when
heated to decomposition (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI ~ USE INFORMATION
Material is used as a systemic insecticide for plants and as an acaricide
(*Merck 1976). Not registered as a pesticide in the U.S. (USEPA/Pesticide
Index 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Liquid Pesticides) Use water spray to
knock down vapors. Attempt to stop leak if it can be done without hazard.
Avoid breathing vapors. Keep upwind. Avoid bodily contact with material.
Do not handle broken packages without protective equipment.
Wash away any material which may have contacted the body with copious
amounts of water or soap and water (*Student 1981).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
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CAS Registry Number: 152-16-9
Page 4 of 4
DIPHOSPHORAMIDE, OCTAMETHYL-
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 152-16-9
Page 1 of 3
Emergency First Aid Treatment Guide
for
DIPHOSPHORAMIDE, OCTAMETHYL-
(152-16-9)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Viscous liquid.
Commercial Form - Dark brown viscous liquid (technical grade).
Use - Pesticide.
Caution: Avoid sources of extreme heat including fire. Di phosphor amide,
octamethyl- will liberate toxic phosphorus oxides when heated to
decomposition.
Other Names - OMPA, Omapacide, Ompatox, Ompax, Pestox III, Schradan, Systam,
Systophos, Sytam.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
atropine, pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Diphosphoramide, Octamethyl- [OMPA] Exposure:
Note: Octamethyl diphosphoramide is a cholinesterase inhibitor.
Acute exposure to OMPA may produce the following signs and symptoms: pinpoint
pupils, blurred vision, headache, dizziness, muscle spasms, and profound
weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also
occur. The heart rate may decrease following oral exposure or increase
following dermal exposure. Hypotension (low blood pressure) and chest pain may
be noted. Hypertension (high blood pressure) is not uncommon. Respiratory
symptoms include dyspnea, respiratory depression, and respiratory paralysis.
Psychosis may occur.
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EFATG
CAS Registry Number: 152-16-9
Page 2 of 3
DIPHOSPHORAMIDE, OCTAMETHYL-
Emergency Life-Support Procedures:
Acute exposure to OMPA may require decontamination and life support for the
victims. Emergency personnel should wear protective clothing appropriate to
the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to OMPA.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to OMPA.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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CAS Registry Number: 152-16-9
Page 3 of 3
DIPHOSPHORAMIDE, OCTAMETHYL-
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of OMPA is unknown or suspected to be greater than 30 minutes,
do not induce vomiting and proceed to Step 4. Ipecac should not be
administered to children under 6 months of age.
Warning: Ingestion of OMPA may result in sudden onset of seizures or loss
of consciousness. Syrup of Ipecac should be administered only if victims
are alert, have an active gag-reflex, and show no signs of impending
seizure or coma. If ANY uncertainty exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
-------
CAS Registry Number: 297-78-9
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - ISOBENZAN
CAS Registry Number: 297-78-9
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 697)
4,7-Methanoisobenzofuran, l,3,4,5,6,7,8,8-Octachloro-l,3,3a,4,7,7a-Hexahydro-;
CP 14,957; ENT 25,545; ENT 25,545-X; l,3,4,5,6,7,8,8-Octachloro-l,3,3a,4,7,7a-
hexahydro-4,7-methanoisobenzofuran; 1,3,4,5,6,7,8,8-Octachloro-2-oxa-3a,4,7,7a-
tetrahydro-4,7-methanoindene; 1,3,4,5,6,7,10,10-Octachloro-4,7-endo-methylene-
4,7,8,9-tetrahydrophthalan; Omtan; SD 4402; Shell 4402; Shell WL 1650;
Telodrin; WL 1650
Chemical Formula: C9H4C18O
Molecular Weight: 411.73
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD60 oral (dog)
1 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II ~ PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 1.87 (Hayes 1982, p. 251)'
Vapor Pressure (mmHg): 0.00001 at 77°F, 25°C (Hayes 1982, p. 251)
Melting Point: 248-252°F, 120-122°C (Merck 1983, pp. 738-739)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (Hayes 1982, p. 251)
-------
CAS Registry Number: 297-78-9
Page 2 of 4
ISOBENZAN
SECTION II (continued)
Appearance and Odor: Crystals (Merck 1983, pp. 738-739). The technical
product is a whitish to light-brown crystalline powder with a mild chemical
odor (Hayes 1982, p. 251)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Hayes 1982, p. 251)
Skin: Yes (Hayes 1982, p. 251)
Ingestion: Yes (Hayes 1982, p. 251)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic. It is absorbed by the skin as well as by the respiratory and
gastrointestinal tract. Symptoms may last for a long time because the
material is eliminated slowly; its half-life in human blood is 2.77 years
(Hayes 1982, p. 251).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Non-flammable and non-explosive (Hayes 1982, p. 251)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Dry Insecticide) Use agent
suitable for type of surrounding fire. Use water in flooding quantities as
fog. Use alcohol foam, carbon dioxide, or dry chemical (Student 1981, p.
290).
Special Fire Fighting Procedures: (Non-Specific — Dry Insecticide)
Avoid breathing dusts and fumes from burning material. Keep upwind. Avoid
bodily contact with the material. Wear full protective clothing including
boots, protective gloves, goggles, and wear self-contained breathing
apparatus (Student 1981, p.290).
Unusual Fire and Explosion Hazards: Chlorine is evolved when this
material is heated above 410°F, 210°C (Hayes 1982, 251).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 297-78-9
Page 3 of 4
ISOBENZAN
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Acids, certain metal salts, and
catalytically active carriers (Hayes 1982, p. 251)
Hazardous Decomposition or Byproducts: Chlorine is evolved if material is
heated above 410°F, 210°C (Hayes 1982, p. 251).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
This material is used as an insecticide (Merck 1983, pp. 738-739). Not
registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Dry Insecticide) Keep upwind. Avoid bodily contact with
the material (Student 1981, p. 290).
(Non-Specific -- Insecticide, Dry, n.o.s.) Keep unnecessary people
away; isolate hazard area and deny entry. Small spills: absorb with
sand or other noncombustible absorbent material and place into containers
for later disposal. Small dry spills: with clean shovel place material
into clean, dry container and cover; move containers from spill area.
Large spills: dike far ahead of spill for later disposal (DOT 1984, Guide
53).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/LIMITED**
Butyl/Neoprene POOR/LIMITED**
PVC POOR/LIMITED**
-------
-S Registry Number: 297-78-9
1 v.ge 4 of 4
ISOBENZAN
SECTION VIII (continued)
Viton POOR/LIMITED**
Viton/Neoprene POOR/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms of exposure include headache,
dizziness, drowsiness, irritability, and numbness of the legs. Convulsions
may occur (Hayes 1982, p. 251).
Emergency and First Aid Procedures: (Non-Specific -- Insecticide, Dry,
n.o.s.) Move victim to fresh air; call emergency medical care. Remove and
isolate contaminated clothing and shoes at the site. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes (DOT 1984, Guide 53).
-------
CAS Registry Number: 297-97-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- THIONAZIN
CAS Registry Number: 297-97-2
Synonyms: Phosphorothioic Acid, O,O-Diethyl O-Pyrazinyl Ester; AC 18133; ACC
18133; American Cyanamid 18133; CL 18133; Cynem; O,O-Diethyl O-2-Pyrazinyl
Phosphorothioate; Diethyl O-2-Pyrazinyl Phosphorothionate; O,O-Diethyl
O-2-Pyrazinyl Phosphothionate; O,0-Diethyl O-Pyrazinyl Thiophosphate; EN 18133;
ENT 26,680; Ethyl Pyrazinyl Phosphorothioate; Experimental Nematocide 18,133;
Nemafos; Nemaphos; Nematocide; Phosphorothioic Acid, O,O-Diethyl O-2-Pyrazinyl
Ester; Pyrazinol, O-Ester with O,O-Diethyl Phosphorothioate; Zinophos
Chemical Formula: C8H1SN2O3PS
Molecular Weight: 248.26
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral (rat)
3.5 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II « PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 176°F, 80°C at 0.001 mmHg (Hawley 1981, p. 1019)
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): 0.003 at 30°C (Merck 1983, p. 1338)
Melting Point: 29°F, -1.7°C (Hawley 1981, p. 1019)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (Hawley 1981, p. 1019), 1140 ppm at
24.8°C (*Spencer 1982)
-------
CAS Registry Number: 297-97-2
! age 2 of 4
THIONAZIN
SECTION II (continued)
Appearance and Odor: Amber liquid (Hawley 1981, p. 1019); pure compound
is almost colorless liquid and technical product is light brown to tan
mobile liquid (*Spencer 1982)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1019)
Skin: Yes (Hawley 1981, p. 1019)
Ingestion: Yes (Hawley 1981, p. 1019)
Health Hazards (Acute, Delayed, and Chronic): Cholinesterase inhibitor
(Hawley 1981, p. 1019). (Non-Specific — Organic Phosphate Compound,
Liquid, Poison B). Poisonous; may be fatal if inhaled, swallowed or
absorbed through skin. Contact may cause burns to skin and eyes (DOT 1984,
Guide 55).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific ~ Organic Phosphate Compound,
Liquid, Poison B). Extinguish with dry chemical, carbon dioxide, water
spray, or foam. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
(Non-Specific -- Parathion) Extinguish fire using agent suitable for type
of surrounding fire. Use water in flooding quantities as fog. Use foam,
carbon dioxide, or dry chemicals (Student 1981, p. 392).
Special Fire Fighting Procedures: (Non-Specific — Organic Phosphate
Compound, Liquid, Poison B). Keep unnecessary people away; stay upwind;
wear positive pressure breathing apparatus and special protective clothing;
remove and isolate contaminated clothing (DOT 1984, Guide 55).
(Non-Specific -- Organic Phosphate Mixture, Liquid, Poison B). Do not
extinguish fire unless flow can be stopped (Student 1981, p. 392).
(Non-Specific -- Parathion) Avoid breathing dusts, and fumes from burning
materials. Avoid body contact with materials. Wear full protective
clothing (Student 1981, p. 392).
-------
CAS Registry Number: 297-97-2
Page 3 of 4
THIONAZIN
SECTION IV (continued)
Unusual Fire and Explosion Hazards: (Non-Specific — Organic Phosphate
Compound, Liquid, Poison B). This material may burn but does not ignite
readily (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: (Non-Specific -- Organic Phosphate
Compound, Liquid, Poison B). Fire may produce irritating or poisonous
gases (DOT 1984, Guide 55).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI ~ USE INFORMATION
It is used in insecticides, fungicides, and nematocides (Hawley 1981, p.
1019). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index
1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Organic Phosphate Compound, Liquid, Poison B). Do not
touch spilled material; stop leak if possible; use water spray to reduce
vapors. Small spill: take up with sand or other noncombustible absorbent
material and place into container for later disposal. Large spills: dike
far ahead of spill for later disposal (DOT 1984, Guide 55). (Non-Specific
~ Parathion) Avoid breathing vapors. Avoid bodily contact with
materials. Do not handle broken packages without protective equipment.
Wash away any material which may have contacted the body with copious
amounts of water or soap and water (Student 1981, p. 392).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
-------
CAS Registry Number: 297-97-2
Page 4 of 4
THIONAZIN
SECTION VIII (continued)
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: (Non-Specific — Parathion). Acute
effects include loss of appetite, nausea, vomiting, diarrhea, excessive
salivation, pupillary constriction, bronchoconstriction, muscle twitching,
convulsions, and coma (Merck 1983, p. 1010).
Emergency and First Aid Procedures: (Non-Specific -- Organic Phosphate
Compound, Liquid, Poison B). Move victim to fresh air; call emergency
medical care. If not breathing give artificial respiration; if breathing
is difficult give oxygen. "In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes; speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site (DOT 1984, Guide 55).
(Non-Specific -- Organic Phosphate Mixture, Liquid, Poison B). Wash away
any material which may have contacted the body with copious amounts of
water or soap and water (Student 1981, p. 381).
COMMENTS:
Sources searched and no information found:
Hayes 1982
Weast 1979
Sax 1984
Clayton and Clayton 1981-82
NFPA 1984
NIOSH/OSHA 1978
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CAS Registry Number: 298-00-0
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PARATHION-METHYL
CAS Registry Number: 298-00-0
Synonyms: Phosphorothioic Acid, O,O-Dimethyl O-(p-Nitrophenyl) Ester (Dry
Mixture); Methyl Parathion; Azofos; Azophos; BAY 11405; Bladan-M; Dalf;
Dimethylfenitrothion; Dimethyl 4-Nitrophenyl Phosphorothionate; Dimethyl
p-Nitrophenyl Phosphorothionate; Dimethyl p-Nitrophenyl Thiophosphate; Dimethyl
Parathion; E 601; ENT 17,292; Folidol M; Folidol M-40; Gearphos; M-Parathion;
Meptox; Metacid 50; Metacide; Metafos; Metafos (Pesticide); Metaphos; Methyl-E
605; Methylthiophos; Metron; Metron (Pesticide); NCI-C02971; Nitrox; Nitrox 80;
O,O-Dimethyl O-(p-Nitrophenyl) Phosphorothioate; O,O-Dimethyl O-(p-Nitrophenyl)
Thionophosphate; O,O-Dimethyl O-(p-Nitrophenyl) Thiophosphate; Oleovofotox;
Parathion Methyl Homolog; Partron M; Penncap M; Penncap MLS; Phenol, p-Nitro-,
O-Ester with O,O-Dimethyl Phosphorothioate; Phosphorothioic Acid, O,O-Dimethyl
O-(4-Nitrophenyl) Ester; Quinophos; Sinafid M-48; Thiophenit; Vofatox; Wofatox;
Wofotox; 8056 HC
Chemical Formula: C8H10NO5PS
Molecular Weight: 263.23
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.034 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 100 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 1.358 at 20°C (*Merck 1983)
Vapor Pressure (mmHg): 0.0000097 at 20°C (*Worthing 1979)
Melting Point: 99-100°F, 37-38°C (*Merck 1983)
-------
CAS Registry Number: 298-00-0
Page 2 of 4
PARATHION-METHYL
SECTION II (continue:;)
Vapor Density (Air.=l): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 50 mg/liter (*Merck 1983)
Appearance and Odor: White crystalline solid or powder (*NFPA 1978); odor
like rotten eggs or garlic ("CHRIS 1978). Commercial product is a liquid
consisting of 80 percent methyl parathion and 20 percent xylene (NFPA 1984,
pp. 49-64); light to dark tan ("Worthing 1979).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: TWA 0.2 mg/m8 (skin) (ACGIH 1986-7, p.24)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): This material is extremely
toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7 drops and
1 teaspoonful for a 150-lb. person (*Gosselin 1984). Chronic toxicity does
not appear to be a major consideration (*NRC 1977).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not flammable at normal temperatures ("Clayton
and Clayton 1982); commercial product, containing xylene, has flashpoint of
115°F (OC) (NFPA 1984, pp. 49-64).
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon dioxide,
water spray, or foam. For large fires, use water spray, fog, or foam (*DOT
1984).
Special Fire Fighting Procedures: Fight fire from maximum distance. Dike
fire control water for later disposal; do not scatter the material ("DOT
1984). Wear special protective clothing ("NFPA 1978).
Unusual Fire and Explosion Hazards: Poisonous gases are produced in fire
and when heated ("CHRIS 1978). Decomposition may lead to sufficient
-------
CAS Registry Number: 298-00-0
Page 3 of 4
PARATHION-METHYL
SECTION IV (continued)
internal pressure to cause the container to rupture violently (NFPA 1984,
pp. 49-64).
NFPA Flammability Rating: 1 (solid); 3 (xylene solution)
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: High temperatures (120°F) cause decomposition
(NFPA 1984, pp. 49-64).
Incompatibility (Materials to Avoid): Oxidizing materials (NFPA 1984, pp.
49-64).
Hazardous Decomposition or Byproducts: Decomposition may lead to rupture
of containers (NFPA 1984, pp. 49-64).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
This material is used as an insecticide on over 50 crops, primarily cotton,
and on several ornamentals (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do it without risk.
Use water spray to reduce vapors. Small spills: take up with sand or
other non-combustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry containers and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (*DOT 1984).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
C \S Registry Number: 298-00-0
I age 4 of 4
PARATHION-METHYL
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 298-00-0
Page 1 of 3
Emergency First Aid Treatment Guide
for
PARATHION-METHYL
(298-00-0)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - White crystalline solid or powder.
Odor - Resembling rotten eggs or garlic.
Commercial Forms - Emulsifiable concentrates, wettable powders, dusts, or light
to dark tan liquid consisting of 80% parathion-methyl and 20% xylene.
Use - Insecticide.
Materials to Avoid - Oxidizers.
Other Names - Dalf; Dimethyl parathion; ENT-17,292; Folidol-M; Meptox;
Metacide; Metaphos; Metron; Nitrox; Partron M; Penncap M; phosphorothioic acid,
O,O-dimethyl O-(p-nitrophenyl)ester; Quinophos; Thiophenit; Vofatox; Wofatox.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
atropine, pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Parathion-Methyl Exposure:
Note: Parathion-methyl is a cholinesterase inhibitor.
Acute exposure to parathion-methyl may produce the following signs and
symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms,
and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma
may also occur.
The heart rate may decrease following oral exposure or increase following
dermal exposure. Hypotension (low blood pressure) may occur although
hypertension (high blood pressure) is not uncommon. Chest pain may be noted.
Respiratory symptoms include dyspnea (shortness of breath), respiratory
depression, and respiratory paralysis. Psychosis may occur.
-------
i-FATG
CAS Registry Number: 298-00-0
Page 2 of 3
PARATHION-METHYL
Emergency Life-Support Procedures:
Acute exposure to parathion-methyl may require decontamination and life support
for the victims. Emergency personnel should wear protective clothing
appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to parathion-methyl.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to parathion-methyl.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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EFATG
CAS Registry Number: 298-00-0
Page 3 of 3
PARATHION-METHYL
Ingestion Exposure:
J. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of parathion-methyl is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of parathion-methyl may result in sudden onset of
seizures or loss of consciousness. Syrup of Ipecac should be
administered only if victims are alert, have an active gag-reflex, and
show no signs of impending seizure or coma. If ANY uncertainty exists,
proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 298-02-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PHORATE
CAS Registry Number: 298-02-2
Synonyms: Phosphorodithioic Acid, O,O-Diethyl S-(EthyIthio)MethyI Ester;
Methanethiol, (Ethylthio)-, S-Ester with O,O-Diethylphosphorodithioate;
O,O-Diethyl S-Ethylmercaptomethyl Dithiophosphonate; O,O-Diethyl
S-Ethylthiomethyl Dithiophosphonate; O,O-Diethyl S-(Ethylthio)methyl
Dithiophosphonate; Experimental Insecticide 3911; L 11/6; Thimet; American
Cyanamid 3,911; AC 3911; American Cyanamid 3911; El 3911; ENT 24,042, ENT
24042; Granutox; O,O-Diethyl Ethylthiomethyl Phosphorodithioate; O,O-Diethyl
S-Ethylmercaptomethyl Dithiophosphate; O,O-Diethyl S-Ethylthiomethyl
Thiothionophosphate; Phorate 10G; Rampart; Thimet 10G; Timet; Vegfru; Vergfru
Foratox; VUAgT 182
Chemical Formula: C7H17O2PS3
Molecular Weight: 260.39
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.011 mg/liter for 1 hour (*NIOSH/RTECS 1985)
TPQ: 10 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 257-261°F, 125-127°C at 2 mmHg (*Merck 1983)
Specific Gravity (H2O=1): 1.156 at 25°C (*Merck 1983)
Vapor Pressure (mmHg): 0.00084 at 20°C (*Merck 1983)
Melting Point: -45°F, -42.9°C (*Spencer 1982)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
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CAS Registry Number: 298-02-2
Page 2 of 4
PHORATE
SECTION II (continued)
Solubility in Water: 50 mg/liter (*Merck 1983)
Appearance and Odor: Clear liquid (*Merck 1983); objectionable odor
(*Osol 1980)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: TWA 0.05 mg/ms (skin); STEL 0.2 mg/ms (skin) (*ACGIH 1983)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*ACGIH 1980)
Skin: Yes (*ACGIH 1980)
Ingestion: Yes (*ACGIH 1980)
Health Hazards (Acute, Delayed, and Chronic): This material is one of the
more toxic organophosphorus insecticides (*Osol 1980). It is a
cholinesterase inhibitor that acts on the nervous system, and produces
toxicity similar to Parathion. The probable oral lethal dose for humans is
less than 5 mg/kg, i.e. a taste (less than 7 drops) for a 70 kg (150 Ib.)
person (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific - Orgahophosphorous Pesticide)
Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam
(DOT 1984, Guide 55)
Special Fire Fighting Procedures: (Non-Specific -- Organophosphorous
Pesticide) Wear positive pressure self-contained breathing apparatus.
Move container from fire area if you can do it without risk. Fight fire
from maximum distance. Dike fire control water for later disposal; do not
scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Shock can shatter containers,
releasing the contents. When heated to decomposition, toxic fumes of
sulfur oxides, phosphorus oxides, and nitrogen oyi:; ^ emitted (Sax
1984, p. 2208).
NFPA Flammability Rating: Not Found
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CAS Registry Number: 298-02-2
Page 3 of 4
PHORATE
SECTION V ~ REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Merck 1983)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Hydrolyzed in water and alkalies
(*Merck 1983).
Hazardous Decomposition or Byproducts: When heated to decomposition,
sulfur oxides, phosphorus oxides, and nitrogen oxides are emitted (Sax
1984, p. 2208)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI ~ USE INFORMATION
This material is used as an insecticide and acaricide; it is applied to
plants and soil (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Pesticide) Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Remove and isolate
contaminated clothing at the site. Do not touch spilled material; stop
leak if you can do it without risk. Use water spray to reduce vapors.
Small spills: take up with sand or other noncombustible absorbent material
and place into containers for later disposal. Large spills: dike far
ahead of spill for later disposal (DOT 1984, Guide 55).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical aftalog.
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CAS Registry Number: 298-02-2
Page 4 of 4
PRORATE
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 298-02-2
Page 1 of 3
Emergency First Aid Treatment Guide
for
PRORATE
(298-02-2)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Clear liquid.
Odor - Objectionable.
Commercial Forms - 2.5, 5, 10, and 20% pure granules.
Use - Pesticide.
Caution: Phorate will form toxic mixtures of sulfur oxides, phosphorus oxides,
and nitrogen oxides when heated to decomposition. Avoid sources of extreme
heat.
Other Names - American Cyanamid 3911, Granutox, Rampart, Thimenox, Thimet,
Vegfru, O,O-diethyl S-ethylmercaptomethyl dithiophosphonate.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
atropine, pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Phorate Exposure:
Note: Phorate is a cholinesterase inhibitor.
Acute exposure to phorate may produce the following signs and symptoms:
pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and
profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may
also occur.
The heart rate may decrease following oral exposure or increase following
dermal exposure. Chest pain may be noted. Hypotension (low blood pressure)
may occur, although hypertension (high blood pressure) is not uncommon.
Dyspnea (shortness of breath) may be followed by respiratory collapse.
Giddiness is common.
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EFATG
CAS Registry Number: 298-02-2
Page 2 of 3
PRORATE
Emergency Life-Support Procedures:
Acute exposure to phorate may require decontamination and life support for the
victims. Emergency personnel should wear protective clothing appropriate to
the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to phorate.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to phorate.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5, Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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EFATG
CAS Registry Number: 298-02-2
Page 3 of 3
PHORATE
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of phorate is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of phorate may result in .sudden onset of seizures or
loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 298-04-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- DISULFOTON
CAS Registry Number: 298-04-4
Synonyms: Phosphorodithioic Acid, O,O-Diethyl S-(2-(Ethylthio)Ethyl) Ester;
Bay 19639; Bayer 19639; Di-syston; Di-syston G; Dimaz; Disulfaton; Disystox;
Dithiodemeton; Dithiosystox; Dution; Ekatin TD; ENT 23,437; ENT-23437; Ethyl
Thiometon; Ethylthiometon B; Frumin; Frumin AL; Frumin G; Glebofos; M 74
(Pesticide); M-74; 0,O-Diethyl 2-Ethylthioethyl Phosphorodithioate; O,O-Diethyl
S-(2-(Ethylthio)Ethyl) Phosphorodithioate; O,O-Diethyl S-(2-Eththioethyl)
Phosphorodithioate; O,O-Diethyl S-(2-Eththioethyl)Thiothionophosphate;
O,O-Diethyl S-(2-Ethylmercaptoethyl) Dithiophosphate; O,O-Diethyl
S-2-(Ethylthio)Ethyl Phosphorodithioate; O,O-Ethyl S-2(Ethylthio)Ethyl
Phosphorodithioate; Phosphorodithioic Acid, O,O-Diethyl S-(2-(Ethylthio)Ethyl)
Ester; Phosphorodithionic Acid, S-2-(Ethylthio)Ethyl O,O-Diethyl Ester; S 276;
S-2-(Ethylthio)Ethyl O,O-DiethyI Ester of Phosphorodithioic Acid; Solvirex;
Thiodemeton; Thiodemetron; Vuagt 1-4; Vuagt 1964
Chemical Formula: C8H19O2PS3
Molecular Weight: 274.38
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDBO oral
(rat) 2 mg/kg (*NIOSH/RTECS 1985).
TPQ: 500 (pounds)
RQ: 1 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 270-271°F, 132-133°C at 1.5 mmHg (*Merck 1976)
Specific Gravity (H2O=1): 1.144 (*Merck 1976)
Vapor Pressure (mmHg): 0.00018 at 20°C (*Spencer 1973)
Melting Point: Greater than -13°F, -25°C (*Sunshine 1969)
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>S Registry Number: 298-04-4
ge 2 of 4
SECTION II (continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 25 mg/liter at 23°C (*NRC 1977)
Appearance and Odor: Oily, colorless liquid when pure; technical product
is dark yellowish oil (*Spencer 1973). It has a characteristic sulfur odor
(*Sax 1975).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: TWA 0.1 mg/ms (ACGIH 1986-7, p.18)
IDLH: Not Found
Other Limits Recommended: An airborne limit of 0.1 mg/ms should serve to
limit general room contamination (* ACGIH 1980).
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): It is classified as super
toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste
(less than 7 drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). It is
poisonous and may be fatal if inhaled, swallowed, or absorbed through the
skin. Contact may cause burns to skin and eyes (*DOT 1984).
Medical Conditions Generally Aggravated by Exposure: Not found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Fight fire from maximum distance. Dike
fire control water for later disposal; do not scatter the material. Wear
positive pressure breathing apparatus and special protective clothing (DOT
1984, Guide 55).
Unusual Fire and Explosion Hazards: Material nu but does not ignite
easily. Cylinder may explode in the heat of fire ~ous gases may be
generated from the fire or runoff water (DOT I •„ ide 55).
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CAS Registry Number: 298-04-4
Page 3 of 4
DISULFOTON
SECTION IV (continued)
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Oxidizable in air (*Sunshine 1969).
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated poisonous gases may be
given off (DOT 1984, Guide 55).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Major uses include insecticide for mites and aphids on small grains, corn,
sorghum, cotton, and other field crops, fruits, nuts, and ornamentals
(*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spill material. Exposure by skin contact is likely to be more
significant than inhalation (*ACGIH 1980). Small spills: take up with
sand or other noncombustible absorbent materials and place into containers
for later disposal. Large spills: dike far ahead of spill for later
disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
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CAS Registry Number: 298-04-4
Page 4 of 4
DISULFOTuN
SECTION VIII (continued)
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 298-04-4
Page 1 of 3
Emergency First Aid Treatment Guide
for
DISULFOTON
(298-04-4)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Form - Oily brown, yellow, or colorless liquid.
Odor - Pure compound has characteristic sulfur .odor, commercial form has
aromatic odor.
Commercial Forms - Granules, powder, emulsifiable concentrate, dark yellow oil.
Use - Pesticide.
Caution: Containers may explode when exposed to high temperatures. Toxic
gases may be liberated. Avoid sources of extreme heat.
Other Names - Di-syston, disystox, Dithiosystox, Dution, Frumin, Glebofos,
Solvirex, Thiodemeton, O,O-diethyl S-2-(ethylthio)ethyl phosphorodithioate.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, syrup of Ipecac, activated
charcoal, saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate,
pralidoxime, diazepam, phenytoin, phenobarbital.
Signs and Symptoms of Acute Disulfoton Exposure:
Note: Disulfoton is a cholinesterase inhibitor.
Acute exposure to disulfoton may produce the following signs and symptoms:
pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and
profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may
also occur.
The heart rate may decrease following oral exposure or increase following
dermal exposure. Hypotension (low blood pressure) and chest pain may be noted.
Hypertension (high blood pressure) is not uncommon. Respiratory symptoms
include dyspnea (shortness of breath), respiratory depression, and respiratory
paralysis. Psychosis may occur.
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CAS Registry Number: 298-04-4
Page 2 of 3
DISULFOTON
Emergency Life-Support Procedures:
Acute exposure to disulfoton may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to disulfoton.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to disulfoton.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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EFATG
CAS Registry Number: 298-04-4
Page 3 of 3
DISULFOTON
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of disulfoton is unknown or suspected to be greater than
30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should
not be administered to children under 6 months of age.
Warning: Ingestion of disulfoton may result in sudden onset of seizures
or loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 300-62-9
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- AMPHETAMINE
CAS Registry Number: 300-62-9
Synonyms: Phenethylamine, alpha-Methyl; (+-)-alpha-Methylbenzene- ethanamine;
(+-)-alpha-Methyl Phenethylamine; (+-)-alpha-Methylphenyl ethylamine;
(+-)-beta-Phenylisopropylamine; (+-)-Desoxynorephedrine;
(Phenylisopropyl)amine; l-Phenyl-2-aminopropane; Acetedron; Adipan; Allodene;
Anorexide; Anorexine; Benzebar; Benzedrine; Benzeneethanamine, alpha-Methyl-,
(+-); Benzolone; beta-Aminopropylbenzene; DL-l-Phenyl-2-Aminopropane;
DL-alpha-Methylphenethylamine; DL-Amphetamine; DL-Benzedrine; Elastonon; Finam;
Isoamyne; Isomyn; Mecodrin; Norephedrane; Norephedrine, deoxy-; Novydrine;
Oktedrin; Ortedrine; Percomon; Phenedrine; Profamina; Propisamine; Psychedrine;
Racemic desoxy-nor-ephedrine; Raphetamine; Rhinalator; Simpatedrin; Simpatina;
Sympamine; Sympatedrine; Weckamine
Chemical Formula: C9H1SN
Molecular Weight: 135.20
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(mouse) 22mg/kg (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 392-397°F, 200-203°C (*Merck 1976)
Specific Gravity (H2O=1): 0.913 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 4.65 (Sax 1984, p. 271)
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CAS Registry Number: 300-62-9
Page 2 of 4
AMPHETAMINE
SECTION II (continued)
Evaporation Rate (Butyl acetate=l): Evaporates slowly at room temperature
(*Merck 1976).
Solubility in Water: Slightly soluble (*Merck 1976).
Appearance and Odor: Colored liquid; amine odor (*Merck 1976).
SECTION III ~ HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Not Found
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
extremely hazardous. Probable lethal dose in humans is 5-50 mg/kg or 7
drops to 1 teaspoon for a 70 kg (150 Ib.) person (*Gosselin 1976). Habit
forming drug which affects the central nervous system (Hawley 1981, p. 65).
Medical Conditions Generally Aggravated by Exposure: Excessive use may
lead to tolerance and physical dependence (*Merck 1976). Death is possible
(Gosselin 1976, p. 11-369).
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 80°F, 26.6°C (no method given) (Hawley 1981,
p. 65)
Flammable Limits: It is flammable (Hawley 1981, p. 65)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with carbon dioxide or dry chemical
(*Sax 1975).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Dangerous when exposed to heat or
flames (*Sax 1975).
NFPA Flammability Rating: Not Found
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CAS Registry Number: 300-62-9
Page 3 of 4
AMPHETAMINE
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Can react with oxidizing materials
(*Sax 1975).
Hazardous Decomposition or Byproducts: Upon decomposition, nitrogen
oxides are emitted (*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Amphetamine is used as a pharmaceutical (Hawley 1981, p. 65). It is a
central nervous system stimulant (*Rossoff 1974).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Drugs, n.o.s.) Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas.
Shut off ignition sources; no flares, smoking or flames in hazard
area. Keep combustibles (wood, paper, oil, etc.) away from spilled
material. Do not touch spilled material. Small spills: absorb with
sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 11).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Nitrile GOOD/LIMITED**
Viton/Neoprene POOR/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
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CAS Registry Number: 300-62-9
Page 4 of 4
AMPHETAMINE
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Dry mouth, metallic taste, loss of
appetite, nausea, vomiting, diarrhea, abdominal cramps, headache,
chilliness, flushing or pallor, palpitation, restlessness, dizziness,
tremor, hyperactive reflexes, talkativeness, tenseness, irritability,
weakness, insomnia, fever, confusion. With large doses, irregular
heartbeat, pain and difficulty in urination (*Goodman 1975). Convulsions,
coma, circulatory collapse (Gosselin 1976, p. H-369).
Emergency and First Aid Procedures: (Non-Specific — Drugs, n.o.s.) Move
victim to fresh air; call emergency medical care. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case
of contact with material, immediately flush skin or eyes with running water
for at least 15 minutes. Remove and isolate contaminated clothing and
shoes at the site. Keep victim quiet and maintain normal body temperature
(DOT 1984, Guide 11).
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CAS Registry Number: 302-01-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- HYDRAZINE
CAS Registry Number: 302-01-2
Synonyms: Diamine; Hydrazine Anhydrous; Hydrazine Base; Hydrazine, Anhydrous;
Levoxine
Chemical Formula: H4N2
Molecular Weight: 32.05
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC60 inhalation
(mouse) 0.33 mg/Liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 1 (pounds) (statutory); 1 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II ~ PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 236.3°F, 113.5°C (*Merck 1983)
Specific Gravity (H2O=1): 1.011 at 15°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 14.4 at 25°C (*Sunshine 1969)
Melting Point: 36°F, 2.0°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (*Merck 1983)
Appearance and Odor: Colorless, oily liquid with penetrating ammonia-like
odor (*Merck 1983).
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CAS Registry Number: 302-01-2
Page 2 of 4
HYDRAZINE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 1 ppm (1.3 mg/m3) (NIOSH 1987, p.136)
ACGIH TLV: TWA 0.1 ppm (0.1 mg/ms) (skin) (ACGIH 1986-87, p.20)
IDLH: 80 ppm (*Encyc Occupat Health and Safety 1983)
Other Limits Recommended: Short-term inhalation limits - 1 ppm for 30
minutes (Weiss 1980, p. 509); Occupational Exposure to Hydrazines
Recommended Standard Air Ceiling 0.04 mg/ms/2 hours (*NIOSH/RTECS 1985).
Industrial Substance Suspect of Carcinogenic Potential for Humans --
Recommended TLV 0.1 ppm (skin) (ACGIH 1984, p. 42). NIOSH: 0.04 mg/ms
120-minute ceiling (NIOSH 1987, p.136). SPEGL 0.12 ppm (60 minutes) (NRC
I985b, pp. 5-22).
Routes of Entry: Inhalation: Yes (NIOSH/OSHA 1978, p. 110)
Skin: Yes (NIOSH/OSHA 1978, p. 110)
Ingestion: Yes (NIOSH/OSHA 1978, p. 110)
Health Hazards (Acute, Delayed, and Chronic): Target organs affected
include central nervous system; respiratory system; skin and eyes
(NIOSH/OSHA 1978, p. 110). Chronic exposure in humans may cause pneumonia,
liver and kidney damage. Liver damage may be more severe than kidney
damage (Gosselin 1976, p. 11-247). It is a suspected human carcinogen
(ACGIH 1984, p. 42).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 52°C (*Merck 1983)
Flammable Limits:
LEL: 4.7% (*NFPA 1978)
UEL: 100% (*NFPA 1978)
Extinguishing Methods: Small fires: dry chemical, carbon dioxide, water
spray or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide
28).
Special Fire Fighting Procedures: Stay upwind; keep out of low areas.
Wear positive pressure breathing apparatus and protective clothing.
Isolate for one-half mile in all directions if tank car or truck is
involved in fire. Move container from fire area if you can do so without
risk. Dike fire control water for later disposal; do not scatter material.
Spray cooling water on containers that are exposed to flames until well
after fire is out (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: It is a flammable/combustible
material and may be ignited by heat, sparks, or flames. Vapor may travel
to a source of ignition and flash back. Container may explode in heat of
fire. Vapor explosion and poison hazard indoc? : : ors, or in sewers.
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CAS Registry Number: 302-01-2
Page 3 of 4
HYDRAZINE
SECTION IV (continued)
Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 28).
Vapors form explosive mixtures with air (NFPA 1984, pp. 49-52). May
continue to burn in the absence of air (*Bretherick 1979).
NFPA Flammability Rating: 3
SECTION V -- REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Can catch fire when in contact with
porous materials such as wood, asbestos, cloth, earth, and rusty metals
(Weiss 1980, p. 509). Incompatible with oxidizers, hydrogen peroxide,
nitric acid, metal oxides, and strong acids (NIOSH/OSHA 1978,
p. 110).
Hazardous Decomposition or Byproducts: Decomposition gives off toxic
nitrogen compound fumes (*Rumack 1975 to Present).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 509)
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Chemical intermediate for pesticides, blowing agents, photography
chemicals, Pharmaceuticals, antituberculants, textile dyes (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation of vapors (see Section III above). Shut off ignition
sources; no flares, smoking or flames in hazard area. Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal. Keep unnecessary
people away; isolate hazard area and deny entry. Stay upwind; keep out of
low areas. In case of contact with material, immediately flush
skin or eyes with running water for at least 15 minutes (DOT 1984, Guide
28).
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CAS Registry Number: 302-01-2
Page 4 of 4
HYDRAZINE
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED
CPE POOR/LIMITED*
Chlorobutyl GOOD/LIMITED
Neoprene GOOD/LIMITED
• Nitrile GOOD/LIMITED
PVC GOOD/LIMITED
Teflon POOR/LIMITED
Viton POOR/LIMITED*
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 302-01-2
Page 1 of 3
Emergency First Aid Treatment Guide
for
HYDRAZINE
(302-01-2)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics:
Pure Forms - Colorless, fuming, oily liquid.
Odor - Penetrating, ammonialike.
Commercial Form - 97.5% pure liquid in glass bottles, carboys, stainless steel
cans, drums, tank trucks.
Uses - Chemical intermediate, antioxidant, heat stabilizer, corrosion
inhibitor, nickel plating, chain extender in polymerization, component of
rocket fuel, military applications.
Materials to Avoid - Porous materials, oxidizers, acids, water (except for use
in emergency life support).
Caution: Highly flammable and explosive. Avoid sources of extreme heat or
ignition including sparks or fire.
Other Names - Hydrazine anhydrous, Levoxine.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, milk, activated charcoal,
saline cathartic or sorbitol, normal saline, D5W, Ringer's lactate, diazepam,
pyridoxine, phenytoin, phenobarbital.
Signs and Symptoms of Acute Hydrazine Exposure:
Warning: Effects may be delayed for hours to days. Caution is advised.
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EFATG
CAS Registry Number: 302-01-2
Page 2 of 3
HYDRAZINE
Signs and symptoms of acute exposure to hydrazine may include severe eye
irritation, facial numbness, facial swelling, and increased salivation.
Hydrazine vapor may immediately irritate the nose and throat. Headache,
twitching, seizures, convulsions, and coma may also occur. Gastrointestinal
signs and symptoms include anorexia, nausea, and vomiting. Pulmonary edema and
hypotension (low blood pressure) are common. Hydrazine is toxic to the liver,
ruptures red blood cells, and may cause kidney damage. Dermal contact may
result in irritation or severe burns.
Emergency Life-Support Procedures:
Acute exposure to hydrazine may require decontamination and life support for
the victims. Emergency personnel should wear protective clothing appropriate
to the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to hydrazine.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to hydrazine.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with sr and water.
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EFATG
CAS Registry Number: 302-01-2
Page 3 of 3
HYDRAZINE
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz
or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults
250 mL (8 oz or 1 cup). Water or milk should be given only if victims are
conscious and alert.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to
3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 309-00-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ALDRIN
CAS Registry Number: 309-00-2
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 113) 1,4:5,8-
Dimethanonaphthalene, l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-Hexahydro-;
Aldrex; Aldrite; Aldrosol; Aldrin, Cast Solid; Aldrin Mixture, Dry; Aldrin
Mixture, Liquid; Compound 118; Drinox; ENT 15,949; Hexachlorohexahydro-
endo-exo-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-
Hexahydro-l,4,5,8-Dimethanonaphthalene; l,2,3,4,10,lO-Hexachloro-l,4,4a,5,8,8a-
Hexahydro-exo-l,4-endo-5,8-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-
l,4,4a,5,8,8a-Hexahydro-l,4-endo-exo-5,8-Dimethanonaphthalene; HHDN;
NCI-C00044; Octalene; Seedrin; l,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-
Hexachloro-l,4,4a,5,8,8a-Hexahydro-, (1 alpha, 4 alpha, 4a beta, 5 alpha, 8
alpha, 8a beta)-
Chemical Formula: C12H8C16
Molecular Weight: 364.90
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD60 oral
(cat) 10 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds) (statutory); 1 (pounds) (proposed)
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: 293°F, 145°C at 2 mmHg (Hayes 1982, p. 234); decomposes
(NIOSH/OSHA 1978, p. 42)
Specific Gravity (H2O=1): 1.70 at 20°C (Hayes 1982, p. 234)
Vapor Pressure (mmHg): 0.000006 at 25°C (Hayes 1982, p. 234)
Melting Point: (Pure) 219°F, 104°C; (Technical) 120-140°F, 49-60°C (Hayes
1982, p. 234)
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CAS Registry Number: 309-00-2
Page 2 of 4
ALDRIN
SECTION II (continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.027 mg/liter (Hayes 1982, p. 234)
Appearance and Odor: (Pure) Odorless, white solid. (Technical) Tan to
dark brown solid with a mild "chemical" odor (Hayes 1982, p. 234).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: 0.25 mg/ms (NIOSH/OSHA 1978, p. 42)
ACGIH TLV: 0.25 mg/ms (skin) (ACGIH 1986-87, p. 9)
IDLH: 100 mg/m3 (NIOSH/OSHA 1978, p. 42)
Other Limits Recommended: NIOSH: Lowest detectable limit (NIOSH 1987,
p. 46)
Routes of Entry: Inhalation: Yes (NIOSH 1978, p. 42)
Skin: Yes (NIOSH 1978, p. 42)
Ingestion: Yes (NIOSH 1978, p. 42)
Health Hazards (Acute, Delayed, and Chronic): Poisoning by aldrin usually
involves convulsions due to its effects on the central nervous system.
Reproductive effects and liver effects have also been reported (Doull 1980,
p. 383; Hayes 1982, p. 235). It is classified as an extremely toxic
chemical. Probable oral lethal dose for humans is between 7 drops and one
oz. for a 150 Ib. adult human (Gosselin 1976, p. 186). Conflicting reports
of carcinogenicity of this compound remain an area of controversy (Doull
1980, p. 383). Similar chemically and lexicologically to dieldrin
(Gosselin 1984, p. 11-285).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Approximately 150°F or higher (no method
given) (NFPA 1984, p. 49-13)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Flammable (Hayes 1982, p. 234). Extinguish by
using water spray, dry chemical, foam, or carbon dioxide. Use water to
keep fire-exposed containers cool. Use water spray to disperse the vapors
(NFPA 1984, p. 49-13).
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CAS Registry Number: 309-00-2
Page 3 of 4
ALDRIN
SECTION IV (continued)
Special Fire Fighting Procedures: Wear full protective clothing (NFPA
1984, p. 49-13) including positive pressure breathing apparatus. Small
fires: dry chemical, carbon dioxide, water spray, or foam. Large fires:
water spray, fog, or foam. Move container from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of chlorine containing compounds (Sax 1984, p. 153).
Commercial solutions may contain flammable or combustible liquids. The dry
powder will not burn (NFPA 1984, p. 49-13). Container may explode in heat
of fire (DOT 1984, Guide 55).
NFPA Flammability Rating: 1 (solution); 0 (dry)
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Avoid concentrated mineral acids,
acid catalysts, acid oxidizing agents, phenols, or active metals (Hayes
1982, p. 234).
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits toxic fumes of chlorine containing compounds (Sax 1984, p. 153).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Formerly used as an insecticide; manufacture and use have been discontinued
in the USA (Merck 1983, p. 36). Registered as a termicide in the U.S.
(USEPA/Pesticide Index 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation (see Section III). Do not touch spilled material; stop
leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible absorbent material
and place into containers for later disposal. Small dry spills: with clean
shovel place material into clean, dry container and cover; move containers
from spill area. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 55).
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CAS Registry Number: 309-00-2
Page 4 of 4
ALDRIN
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl POOR/LIMITED**
Butyl/Neoprene POOR/LIMITED**
CPE POOR/LIMITED**
Neoprene POOR/LIMITED**
Nitrile POOR/LIMITED**
PE POOR/LIMITED**
PVC POOR/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
-------
EFATG
CAS Registry Number: 309-00-2
Page 1 of 3
Emergency First Aid Treatment Guide
for
ALDRIN
(309-00-2)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Substance Characteristics: ,
Pure Form - Colorless or white crystalline solid.
Odor - None (mild chemical odor in commercial form).
Commercial Forms - Tan to dark brown emulsifiable concentrate, wettable
powders, granules, or dusts in 1- and 5-gaIlon cans or 45-gallon fiber drums.
Use - Insecticide.
Other Names - Aldrite; Aldrosol; Drinox; HHDN; 1,2,3,4,10,10-hexachloro-
l,4,4a,5,8,8a-hexahydro-exo-l,4-endo-5,8-dimethanonaphthalene; Octalene;
Seedrin.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, alcohol, syrup of Ipecac,
activated charcoal, saline cathartic or sorbitol, D5W, normal saline, Ringer's
lactate, diazepam, phenytoin, phenobarbital, thiopental, succinylcholine.
Signs and Symptoms of Acute Aldrin Exposure:
Signs and symptoms of acute exposure to aldrin may be severe and include
headache, dizziness, agitation, nervousness, tremor, seizures, and coma.
Convulsive episodes may alternate with periods of severe central nervous system
depression. Nausea, vomiting, and diarrhea are common.
Hypertension (high blood pressure), tachycardia (rapid heart rate), and cardiac
arrhythmias (abnormal heart beating) may be noted. Respiratory depression may
lead to respiratory arrest. Contact with the skin, eyes, and mucous membranes
may result in redness and irritation. Victims often have an elevated
temperature.
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EFATG
CAS Registry Number: 309-00-2
i'age 2 of 3
ALDRIN
Emergency Life-Support Procedures:
Acute exposure to aldrin may require decontamination and life support for the
victims. Emergency personnel should wear protective clothing appropriate to
the type and degree of contamination. Air-purifying or supplied-air
respiratory equipment should also be worn, as necessary. Rescue vehicles
should carry supplies such as plastic sheeting and disposable plastic bags to
assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to aldrin.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to aldrin.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
5. Wash exposed skin areas three times. Wash initially with soap and water,
follow with an alcohol wash, then again with soap and water.
6. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
7. Transport to a health care facility.
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EFATG
CAS Registry Number: 309-00-2
Page 3 of 3
ALDRIN
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. If breathing is labored, administer oxygen or
other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since
ingestion of aldrin is unknown or suspected to be greater than 30 minutes,
do not induce vomiting and proceed to Step 4. Ipecac should not be
administered to children under 6 months of age.
Warning: Ingestion of aldrin may result in sudden onset of seizures or
loss of consciousness. Syrup of Ipecac should be administered only if
victims are alert, have an active gag-reflex, and show no signs of
impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.
The following dosages of Ipecac are recommended: children up to 1 year
old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults,
30 mL (1 oz). Ambulate (walk) the victims and give large quantities of
water. If vomiting has not occurred after 15 minutes, Ipecac may be
readministered. Continue to ambulate and give water to the victims. If
vomiting has not occurred within 15 minutes after second administration of
Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility.
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CAS Registry Number: 315-18-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - MEXACARBATE
CAS Registry Number: 315-18-4
Synonyms: Carbamic Acid, Methyl-, 4-Dimethylamino-3,5-xylyl Ester; Zectran;
3,5-Dimethyl-4-(Dimethylamino)Phenyl Methylcarbamate; 3,5-Xylenol,
4-(Dimethylamino)-, Methylcarbamate; 4-(Dimethylamino)-3,5-Xylyl
N-Methylcarbamate; 4-(Dimethylamino)-3,5-Dimethylphenol Methylcarbamate
(Ester); 4-(Dimethylamino)-3,5-Dimethylphenyl N-Methylcarbamate;
4-(Dimethylamino)-3,5-Xylenol, Methylcarbamate (Ester); 4-(N,N-Dimethylamino)-
3,5-Xylyl N-Methylcarbamate; 4-Dimethylamino-3,5-Dimethylphenyl
Methylcarbamate; 4-Dimethylamino-3,5-Dimethylphenyl N-Methylcarbamate;
4-Dimethylamino-3,5-Xylenyl N-Methylcarbamate; 4-Dimethylamino-3,5-Xylyl
Methylcarbamate; 4-Dimethylamino-3,5-Xylyl N-Methylcarbamate; Carbamate,
4-Dimethylamino-3,5-Xylyl, N-Methyl-; Carbamic Acid, Methyl-,
4-(Dimethylamino)-3,5-Dimethylphenyl Ester; Carbamic Acid, Methyl-,
4-(Dimethylamino)-3,5-Xylyl Ester; Dowco 139; Dowco-139; ENT 25,766; ENT 25766;
ENT-25,766; MAZ; Methyl-4- Dimethylamino-3,5-Xylyl Carbamate;
Methyl-4-Dimethylamino-3,5-Xylyl Ester of Carbamic Acid; Methylcarbamic Acid
4-(Dimethylamino)-3,5-Xylyl Ester; Mexicarbate; NCI-C00544; OMS-47; Phenol,
4-(Dimethylamino)-3,5-Dimethyl-, Methylcarbamate (Ester); Zactran; Zectane;
Zextran; Phenol, 4-(Dimethylamino)- 3,5-Dimethyl-, Methylcarbamate (Ester)
Chemical Formula: C12H18N2O2
Molecular Weight: 222.29
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(rat) 14 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1000 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
-------
CAS Registry Number: 315-18-4
Page 2 of 4
MEXACARBATE
SECTION II (continued)
Vapor Pressure (mmHg): Less than 0.1 at 139°C (*Merck 1983)
Melting Point: 185°F, 85°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.01% at 25°C (*Merck 1983)
Appearance and Odor: White crystalline solid, odorless (*Martin 1974)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Non-Specific -- Carbamate Pesticide,
Solid, n.o.s) (DOT 1984, Guide 55)
Skin: Yes (Non-Specific — Carbamate Pesticide,
Solid, n.o.s.) (DOT 1984, Guide 55)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic: probable
oral lethal dose for humans is 5-50 mg/kg; between 7 drops and 1
teaspoonful for 70 kg person (150 Ib.) (*Gosselin 1976). (Non-Specific -
Carbamate Pesticide, Solid, n.o.s.) Poisonous; may be fatal if inhaled,
swallowed, or absorbed through skin. Contact may cause burns to skin and
eyes (DOT 1984, Guide 55).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Carbamate Pesticide, Solid,
n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam.
Large fires: water spray, fog, or foam. Dike fire control water for later
disposal; do not scatter the material (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Not Found
-------
CAS Registry Number: 315-18-4
Page 3 of 4
MEXACARBATE
SECTION IV (continued)
Unusual Fire and Explosion Hazards: (Non-Specific — Carbamate Pesticide,
Solid, n.o.s.) Fire may produce irritating or poisonous gases. This
material may burn but does not ignite readily. Container may explode in
heat of fire (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Martin 1974)
Conditions to Avoid: Subject to photo-decomposition in the solid
state (*IARC 1972-1985).
Incompatibility (Materials to Avoid): Decomposition in highly alkaline
media (*Martin 1974).
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 1108).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
It is an insecticide for non-agricultural uses, e.g., lawn and turf,
flowers, gardens, vines, forest lands, woody shrubs and trees and also a
molluscicide. It is not produced commercially in the United States (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific - Carbamate Pesticide) Keep sparks, flames, and other
sources of ignition away. Keep material out of water sources and sewer.
Avoid bodily contact with the material (Student 1981, p. 104).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 315-18-4
Page 4 of 4
MEXACARBATE
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms of carbamate poisoning resemble
those of parathion. This material is similar to carbaryl; symptoms of
carbaryl exposure include nausea, vomiting, abdominal cramps, diarrhea,
excessive salivation, sweating, lassitude and weakness. Runny nose and
sensation of tightness in chest may occur with inhalation exposures.
Blurring or dimness of vision, tearing, eye muscle spasm, loss of muscle
coordination, slurring of speech, and twitching of muscles may also occur
(*Gosselin 1976).
Emergency and First Aid Procedures: (Non-Specific -- Carbamate Pesticide,
Solid, n.o.s.) Move victim to fresh air; call emergency medical care. If
not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 316-42-7
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- EMETINE, DIHYDROCHLORIDE
CAS Registry Number: 316-42-7
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 192) Amebicide;
(-)-Emetine Dihydrochloride; 1-Emetine Dihydrochloride; Emetine, Hydrochloride;
NSC-33669
Chemical Formula: C29H40N2O4 2HC1
Molecular Weight: 553.63
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD60 oral
(rat) 0.012 mg/kg (*NIOSH/RTECS 1985)
TPQ: 1/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 455-491°F, 235-255°C decomposes (Merck 1983, p. 514)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Contains water of hydration varying from 3 to 8
molecules of water; 1 g of hydrated salt dissolves in 7 mL (Merck 1983,
P. 514)
-------
CAS Registry Number: 316-42-7
Page 2 of 4
EMETINE, DIHYDROCHLORIDE
SECTION II (continued)
Appearance and Odor: Clusters of needles after drying at 221°F, 105°C;
turns yellow on exposure to light or heat ((Merck 1983, p. 514)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1275)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic orally. It is an eye irritant (Sax 1984, p. 1275). (Non-Specific —
Emetine) Emetine is classified as extremely toxic. Probable oral lethal
dose for humans is 5-50 mg/kg, or between 7 drops and one teaspoon for a
150-lb person (Gosselin 1984, p. II-244).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Emetine is an alkaloid (Merck 1983, p. 513).
Extinguishing methods for alkaloid salts are as follows. Small fires: dry
chemical, carbon dioxide, water spray, or foam. Large fires: water spray,
fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Procedures for alkaloid salts include
the following. Move container from fire area if you can do so without
risk. Fight fire from maximum distance. Dike fire control water for later
disposal; do not scatter the material. Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of chlorides, hydrogen chloride and oxides of
nitrogen (Sax 1984, p. 1275).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 316-42-7
Page 3 of 4
EMETINE, DIHYDROCHLORIDE
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Turns yellow on exposure to light or heat (Merck
1983, p. 514)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits very toxic fumes of chlorides, hydrogen chloride, and oxides of
nitrogen (Sax 1984, p. 1275).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Emetine, dihydrochloride is an injectable form of emetine (Oilman 1984, p.
1051). It is an antiamebic (Merck 1983, p. 514). Emetine is the active
ingredient of Ipecac (Gosselin 1984, p. 11-244).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
The following procedures should be used for alkaloid salts. Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them.
Remove and isolate contaminated clothing at the site. Do not touch spilled
material; stop leak if you can do it without risk. Use water spray to
reduce vapors. Small spills: take up with sand or other noncombustible
absorbent material and place into containers for later disposal. Small dry
spills: with clean shovel place material into clean, dry container and
cover; move containers from spill area. Large spills: dike far ahead of
spill for later disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 316-42-7
Page 4 of 4
EMETINE, DIHYDROCHLORIDE
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: (Non-Specific — Emetine) Symptoms
include nausea, vomiting, diarrhea, muscle weakness, pain, tenderness,
hypotension, precordial pain and rapid heartbeat (Gosselin 1984, p.
11-244).
Emergency and First Aid Procedures: Emetine is an alkaloid (Merck 1983,
p. 513). Procedures for alkaloid salts are as follows. Move victim to
fresh air; call emergency medical care. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes. Speed in removing material from skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects may
be delayed; keep victim under observation (DOT 1984, Guide 55).
COMMENTS:
Sources searched but no information found:
NFPA 1984
Weiss 1980
ACGIH 1983
NIOSH/OSHA 1978
Encyc Occupat Health and Safety 1983
Weast 1979
Physicians' Desk Reference 1985
Farm Chemicals Handbook 1984
-------
CAS Registry Number: 327-98-0
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- TRICHLORONATE
CAS Registry Number: 327-98-0
Synonyms: 5082A; Agrisil; Agritox; Bay 37289; Bayer 37289; Bayer 5081; Bayer
S 4400; Chemagro 37289; ENT 25,712; ENT-25712; Ethyl
Trichlorophenylethylphosphonothioate; Fenophosphon; Fitosol; O-Ethyl
O-2,4,5-Trichlorophenyl Ethylphosphonothioate; Phenol, 2,4,5-Trichloro-,
O-Ester with O-Ethyl Ethylphosphonothioate; Phosphonothioic Acid, Ethyl-,
O-Ethyl O-(2,4,5-Trichlorophenyl) Ester; Phytosol; Richloronate; S 4400;
Trichloronat
Chemical Formula: C10H12C18O2PS
Molecular Weight: 333.60
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(cat) 10 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 226°F, 108°C at 0.01 mmHg (*Worthing 1979)
Specific Gravity (H2O=1): 1.365 at 20°C/4°C (*Worthing 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 50.mg/liter at 20°C (*Worthing 1979)
-------
AS Registry Number: 327-98-0
i'age 2 of 4
TRICHLOi ONATE
SECTION II (continued)
Appearance and Odor: Amber colored liquid (*Worthing 1979)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Non-Specific -- Organic Phosphorus
Pesticides) (Hayes 1982, p. 301)
Skin: Yes (Non-Specific -- Organic Phosphorus
Pesticides) (Hayes 1982, p. 301)
Ingestion: Yes (Sax 1984, p. 1397)
Health Hazards (Acute, Delayed, and Chronic): Material is an
organophosphate (*Rumack 1975 to Present) and toxic effects are due to
action on the nervous system (Hayes 1982, p. 301). It has high oral
toxicity (Sax 1984, p. 1397) and death can occur in acute poisonings
(*DeReuch 1979). Delayed neurotoxicity has been reported (*Rumack 1975 to
Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Organophosphate Pesticide,
Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Organophosphate
Pesticide, Liquid, n.o.s.) Move container from fire area if you can do it
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of chlorine containing compounds, phosphorus oxides,
and sulfur oxides (Sax 1984, p. 1397).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 327-98-0
Page 3 of 4
TRICHLORONATE
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits very toxic fumes of chlorine containing compounds, phosphorus oxides,
and sulfur oxides (Sax 1984, p. 1397).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Non-systemic insecticide (*Worthing 1979). Not marketed in the U.S.A. or
Canada (Farm Chemicals Handbook 1984, p. C-7). Not registered as a
pesticide in the U.S. (USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation (see Section III above). (Non-Specific — Organophosphate
Pesticide, Liquid, n.o.s.) Do not touch spilled material; stop leak if you
can do so without risk. Use water spray to reduce vapors. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal. Keep unnecessary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces before
entering them. Remove and isolate contaminated clothing at the site
(DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
-------
CAS Registry Number: 327-98-0
Page 4 of 4
TRICHLORONATE
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Headache, dizziness, nausea, salivation,
vomiting, abdominal pain, diarrhea, chest pain, decreased heart rate,
excessive discharge of mucous from the air passages, difficult breathing,
contraction of the pupil, blurred vision, profuse perspiration, muscle
twitching and spasms, profound weakness, psychotic behavior,
uncoordination, unconsciousness, rarely convulsions. Low level absorption
syndrome is similar to influenza. High dosage may cause toxic psychosis
similar to alcoholism. Exposures may be misdiagnosed as asthma and heart
failure (*Rumack 1975 to Present).
Emergency and First Aid Procedures: (Non-Specific -- Organophosphate
Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If breathing
is difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 353-42-4
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- BORON TRIFLUORIDE COMPOUND WITH METHYL ETHER
(1:1)
CAS Registry Number: 353-42-4
Synonyms: (NIOSH/RTECS 1983 Synonym, Volume 1, p. 741) Boron,
Trifluoro(Oxybis(methane))-,(T-4)-; Boron Trifluoride-Dimethyl Ether; (SANSS
1983 Synonyms): Methyl Ether, compound with Boron Fluoride (1:1); Boron
Fluoride Complex with Dimethyl Ether; Boron Trifluoride Compound with Methyl
Ether; Boron Trifluoride Dimethyl Ether Addition Compound; Boron Trifluoride
Dimethyl Etherate; Boron Trifluoride Dimethyl Ether Complex
Chemical Formula: C2H6O BFS
Molecular Weight: 113.89
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LCjow inhalation
(guinea pig) 0.233 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 1,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 126°C at 760 mmHg (Aldrich 1986, p. 190)
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
-------
CAS Registry Number: 353-42-4
Page 2 of 4
BORON TRIFLUORIDE COMPOUND WITH METHYL ETHER (1:1)
SECTION II (continued)
Appearance and Odor: Not Found
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Sax 1984, p. 515)
Skin: Yes (DOT 1984, Guide 29)
Ingestion: Yes (Non-Specific — Boron Compounds)
(Sax 1984, p. 513)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic by inhalation (Sax 1984, p. 515).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This material may react violently with water. For
small fires, use dry chemical, carbon dioxide, water spray, or foam. For
large fires, use water spray, fog, or foam (DOT 1984, Guide 29).
Special Fire Fighting Procedures: Wear self-contained, positive- pressure
breathing apparatus and full protective clothing. Move containers from
fire area if possible. Do not get water inside containers. Spray cooling
water on containers that are exposed to flame until well after fire is out.
Withdraw immediately in case of rising sound from venting safety device or
any discoloration of tank due to fire. Isolate for 1/2 mile in all
directions if tank car or truck is involved in fire (DOT 1984, Guide 29).
Unusual Fire and Explosion Hazards: Fire may produce irritating or
poisonous gases. Flammable/combustible material which may be ignited by
heat spark or flame. Vapors may travel to a source of ignition and flash
back. Container may explode in heat of fire. Vapor explosion hazard
indoors, outdoors, or in sewer. Runoff to sewer may create fire or
explosion hazard (DOT 1984, Guide 29).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 353-42-4
Page 3 of 4
BORON TRIFLUORIDE COMPOUND WITH METHYL ETHER (1:1)
SECTION V ~ REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits toxic fumes of fluorides (Sax 1984, p. 515).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI ~ USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away and isolate hazard area. Stay upwind and
keep out of low areas. Shut off ignition sources. Do not touch
spilled material. Use water spray to reduce vapors, but do not get
water inside containers. For small spills, absorb with sand or other
noncombustible absorbent material and place into containers. For large
spills, dike far ahead of spill for later disposal (DOT 1984, Guide 29).
SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Contact may cause burns to skin and eyes
(DOT 1984, Guide 29).
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Remove and isolate contaminated clothing at site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 29).
-------
CAS Registry Number: 353-42-4
Page 4 of 4
BORON TRIFLUORIDE COMPOUND WITH METHYL ETHER (1:1)
COMMENTS:
Sources searched but no information found:
ACGIH 1983
NIOSH/OSHA 1978
Hawley 1981
Weast 1979
Merck 1983
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Gosselin 1984
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Physicians' Desk Reference 1985
Oilman 1985
-------
CAS Registry Number: 359-06-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - FLUOROACETYL CHLORIDE
CAS Registry Number: 359-06-8
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 252): Acetyl Chloride,
Fluoro-; TL 670
Chemical Formula: C2H2C1FO
Molecular Weight: 96.49
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LClow inhalation
(guinea pig) 0.1 mg/liter/10 minutes (*NIOSH/RTECS 1985)
TPQ: 10 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
-------
CAS Registry Number: 359-06-8
Page 2 of 4
FLUOROACETYL CHLORIDE
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1430)
Skin: Not Found
Ingestion: Yes (Non-Specific -- Chloroacetyl
Chloride) (NFPA 1984, p. 49-29)
Health* Hazards (Acute, Delayed, and Chronic): Highly toxic by inhalation
(Sax 1984, p. 1430). (Non-Specific - Chloroacetyl Chloride) Corrosive to
skin and irritating to eyes (NFPA 1984, p. 49-29).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Chloroacetyl Chloride and
Fluoroacetic Acid) Extinguish with dry chemical, carbon dioxide, water
spray, fog, or foam (DOT 1984, Guide 59).
Special Fire Fighting Procedures: (Non-Specific - Chloroacetyl Chloride
and Fluoroacetic Acid) Spray cooling water on containers that are exposed
to flames until well after fire is out. Move container from fire area if
you can do so without risk. Do not get water in container, as material may
react violently with water (DOT 1984, Guide 59).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of chlorine and fluorine-containing compounds (Sax
1984, p. 1430). (Non-Specific -- Chloroacetyl Chloride and Fluoroacetic
Acid) Some of these materials may ignite combustibles (i.e., wood, paper,
oil, etc.) or react violently with water (DOT 1984, Guide 59).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 359-06-8
Page 3 of 4
FLUOROACETYL CHLORIDE
SECTION V (continued)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits very toxic fumes of chlorine and fluorine-containing compounds (Sax
1984, p. 1430).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Chloroacetyl Chloride and Fluoroacetic Acid) Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Do not touch spilled material; stop leak if
you can do so without risk. Use water spray to reduce vapors
(may react violently with water). Small spills: absorb with
sand or other non-combustible absorbent material and place into containers
for later disposal. Large spills: dike far ahead of spill for later
disposal (DOT 1984, Guide 59).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific ~ Chloroacetyl
Chloride and Fluoroacetic Acid) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If breathing
is difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Remove and
isolate contaminated clothing and shoes at site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 59).
-------
CAS Registry Number: 359-06-8
Page 4 of 4
FLUOROACETYL CHLORIDE
COMMENTS
Sources searched but no information found:
Weast 1979
Hawley 1981
Hayes 1982
DASE 1980
ACGIH 1983
NIOSH/OSHA 1978
Merck 1983
Oilman 1985
Gosselin 1984
Weiss 1980
Clayton and Clayton 1981-82
Farm Chemicals Handbook 1984
Doull 1980
Buchel 1983
-------
CAS Registry Number: 371-62-0
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ETHYLENE FLUOROHYDRIN
CAS Registry Number: 371-62-0
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 252): Ethanol, 2-Fluoro-;
beta-Fluoroethanol; 2-Fluoroethanol; TL 741
Chemical Formula: C2H5FO
Molecular Weight: 64.07
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(dog) 0.007 mg/liter/10 minutes (*NIOSH/RTECS 1985)
TPQ: 10 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 218.3°F, 103.5°C (Weast 1979, p. C-297)
Specific Gravity (H2O=1): 1.1040 at 20°C/4°C (Weast 1979, p. C-297)
Vapor Pressure (mmHg): Not Found
Melting Point: -15.61°F, -26.45°C (Weast 1979, p. C-297)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (Weast 1979, p. C-297)
Appearance and Odor: Liquid (Hayes 1983, p. 500)
-------
AS Registry Number: 371-62-0
. age 2 of 4
ETHYLL. _ FLUOROHYDRIN
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1437)
Skin: Yes (Sax 1984, p. 1437)
Ingestion: Yes (Hayes 1982, p. 500)
Health Hazards (Acute, Delayed, and Chronic): Toxicity rating is the same
as for fluoroacetate, super toxic. The probable oral lethal dose in humans
is a taste (less than 7 drops) for a 70 kg (150 Ib.) person (Gosselin 1984,
p. 11-198). The chemical is highly toxic when inhaled or absorbed through
the skin (Sax 1984, p. 1437). Toxicity depends on its oxidation to
fluoroacetate by tissue alcohol dehydrogenase (Hayes 1982, p. 500).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 31°C (Hayes 1982, p. 500)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Toxic fluoride fumes may be emitted
in a fire (Sax 1984, p. 1437).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits very toxic fumes of fluorides (Sax 1984, p. 1437).
-------
CAS Registry Number: 371-62-0
Page 3 of 4
ETHYLENE FLUOROHYDRIN
SECTION V (continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Ethylene Fluorohydrin is used as a rodenticide (Hayes 1982, p. 500),
insectide (Gosselin 1984, p. III-193), and acaricide (Buchel 1983, p. 177).
Not registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII « PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section III above).
(Non-Specific -- Fluoroacetic Acid) Do not touch spilled material;
stop leak if you can do so without risk. Use water spray to reduce
vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal.
Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 59).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl GOOD/LIMITED**
CPE GOOD/LIMITED**
Viton GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms include tremors, severe muscular
weakness, nausea, headache, and slight swelling of the liver (Hayes 1982,
p. 500). Delayed convulsant (Gosselin 1984, p. II-198).
-------
CAS Registry Number: 371-62-0
Page 4 of 4
ETHYLENE FLUOROHYDRIN
SECTION IX (continued)
Emergency and First Aid Procedures: Acute poisoning should be treated
like poisoning by fluoroacetate. Ethylene fluorbhydrin (2-fluoroethanol)
is listed among the organic fluorine derivatives of fluoroacetic acid
(Hayes 1982, p. 501). The emergency procedures for f luoroacetic acid are:
move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen. In
case of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Remove and isolate contaminated clothing
and shoes at the site. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 59).
COMMENTS
Sources searched but no information found:
Student 1981
DASE 1980
Hawley 1981
NFPA 1984
Weiss 1980
Merck 1983
CHRIS 1978
Farm Chemicals Handbook 1984
-------
CAS Registry Number: 379-79-3
Page 1 of 3
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- ERGOTAMINE TARTRATE
CAS Registry Number: 379-79-3
Synonyms: (SANSS 1983 Synonyms) Ergotamine Bitartrate; Gotamine Tartrate;
Gynergen; Neo-ergotin; Ergotaman-3',6',18-Trione,
12'-Hydroxy-2'-Methyl-5'-(Phenylmethyl)-, (S'.alpha.)-, [R-(R*,R*)]-
2,3-Dihydroxybutanedioate (2:1) (Salt); Ergam; Ergate; Ergomar; Etin; Exmigra;
Rigetamin; Secagyn; Secupan; Ergotamine, Tartrate (2:l)(Salt); Component of
Cafergot
Chemical Formula: C66H70N10O10-C4H6O6
Molecular Weight: 1313.56
SECTION I --REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDlow oral
(rat,rabbit) 1 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 397°F, 203°C, decomposes (Merck 1983, p. 529)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g/500 mL (Merck 1983, p. 529)
-------
CAS Registry Number: 379-79-3
Page 2 of 3
ERGOTAMINE TARTRATE
SECTION II (continued)
Appearance and Odor: Powder or liquid forms available as drugs (Gilman
1985, p. 938).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Gilman 1985, p. 938)
Skin: Not Found
Ingestion: Yes (NIOSH/RTECS 1983, p. 209)
Health Hazards (Acute, Delayed, and Chronic): High oral toxicity and a
convulsant in humans (Sax 1984, p. 1295).
Medical Conditions Generally Aggravated by Exposure: People with liver
damage are at a greater risk (Gilman 1985, p. 937).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Protect from light and heat (Merck
1983, p. 529)
Hazardous Decomposition or Byproducts: When * :' to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 198-,. .).
-------
CAS Registry Number: 379-79-3
Page 3 of 3
ERGOTAMINE TARTRATE
SECTION V (continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
The major uses of the ergot alkaloids fall into two categories:
applications in obstetrics and treatment of migraine headaches (Oilman
1985, p. 937).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Alkaloid, n.o.s.) Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas.
Do not touch spilled material; stop leak if you can do so without risk.
Use water vapor to reduce vapors. Absorb spills with sand or other
noncombustible absorbent material. Small dry spills: with clean shovel
place material into clean, dry container and cover; move containers from
spill area. For large spills, dike far ahead of spill for later
disposal (DOT 1984, Guide 55).
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Nausea and vomiting occur in some
patients after oral administration. Weakness in the legs is common and
muscle pains in the extremities may occur. Numbness and tingling of the
fingers and toes may also occur (Oilman 1985, p. 938).
Emergency and First Aid Procedures: (Non-Specific -- Alkaloid, n.o.s.)
Move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen. In
case of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Speed in removing material from skin is of
extreme importance. Remove and isolate contaminated clothing and shoes at
the site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 465-73-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - ISODRIN
CAS Registry Number: 465-73-6
Synonyms: l,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-Hexachloro-
l,4,4a,5,8,8a-Hexahydro-, endo,endo-; Compound 711; ENT 19,244; Experimental
Insecticide 711; l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-Hexahydro-l,4; 5,8-
endo,endo-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-
Hexahydro-endo,endo-l,4:5,8-Dimethanonaphthalene; l,4:5,8-Dimethanonaphthalene,
l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-Hexahydro-, (1 alpha, 4 alpha, 4a beta,
5 beta, 8 beta, 8a beta)-; SD 3418
Chemical Formula: C12H8C16
Molecular Weight: 364.90
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(rat) 7 mg/kg (*NIOSH/RTECS 1985)
TPQ: 100/10,000 (pounds)
RQ: 1 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 464-468°F, 240-242°C (Sax 1984, p. 1641)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
-------
CAS Registry Number: 465-73-6
Page 2 of 4
ISODRIN
SECTION II (continued)
Appearance and Odor: Solid (*Hawley 1977)
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Non-Specific -- Aldrin)
(Sax 1984, p. 153)
Skin: Yes (Sax 1984, p. 1641)
Ingestion: Yes (Sax 1984, p. 1641)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
extremely toxic. Probable oral lethal dose for humans is 5-50 mg/kg or
between 7 drops and 1 teaspoonful for a 70 kg (150 Ib.) person. It causes
renal damage and hyperactivity of sympathetic nervous system (*Gosselin
1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Material is related to aldrin (*Gosselin 1976).
(Non-Specific — Aldrin) Extinguish by using water spray, dry chemical,
foam, or carbon dioxide. Use water to keep fire exposed containers cool
(NFPA 1984, p. 49-13).
Special Fire Fighting Procedures: (Non-Specific - Aldrin) Wear full
protective clothing (NFPA 1984, p. 49-13) including positive pressure
breathing apparatus. Move container from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific — Aldrin) This
material may burn but may not ignite readily. Container may explode in
heat of fire. Fire and runoff from fire control water may produce
irritating or poisonous gases (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
-------
CAS Registry Number: 465-73-6
Page 3 of 4
ISODRIN
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes (*White-Stevens 1971)
Stable:
Conditions to Avoid: Reactions induced by light or acid
(*White-Stevens 1971)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Material is related to aldrin
(*Gosselin 1976). (Non-Specific — Aldrin) When heated to decomposition
it emits toxic fumes of chlorine (Sax 1984, p. 153).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
No longer used as a pesticide (*NIOSH/RTECS 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Material is related to aldrin (*Gosselin 1976). (Non-Specific -- Aldrin)
Stay upwind; keep out of low areas. Ventilate closed spaces before
entering them. Remove and isolate contaminated clothing at the site.
Do not touch spilled material; stop leak if you can do it without risk.
Use water spray to reduce vapors. Small spills: take up with sand or
other noncombustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry containers and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms experienced are similar to
poisoning by dieldrin and aldrin, including overall discomfort, headache,
nausea, vomiting, dizziness, tremors, convulsions, rise in blood pressure,
fever, disturbances in sleep and behavior, and rapid heartbeat. Death from
respiratory arrest may occur in coma (*Gosselin 1976, *Merck 1976).
-------
CAS Registry Number: 465-73-6
Page 4 of 4
ISODRIN
SECTION IX (continued)
Emergency and First Aid Procedures: Procedures are similar to those for
dieldrin and aldrin poisoning (*Gosselin 1976). Move victim to fresh air;
call emergency medical care. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes. Speed in removing material from skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects may
be delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 470-90-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - CHLORFENVINFOS
CAS Registry Number: 470-90-6
Synonyms: Supona; 2,4-Dichloro-alpha-(Chloromethylene)Benzyl Diethyl
Phosphate; 2-Chloro-l-(2,4-Dichlorophenyl)Ethenyl Diethyl Ester Phosphoric
Acid; 2-Chloro-l-(2,4-Dichlorophenyl)Vinyl Diethyl Phosphate; 4072; Benzyl
Alcohol, 2,4-Dichloro-alpha-(Chloromethylene)-, Diethyl Phosphate;
beta-2-Chloro-l-(2',4'-Dichlorophenyl)Vinyl Diethyl Phosphate; Birlan; Birlane;
C8949; Chlofenvinphos; Chlorofenvinphos; Chlorphenvinfos; Chlorphenvinphos;
Compund 4072; CVP; CVP (Pesticide); Dermaton; Diethyl
l-(2,4-Dichlorophenyl)-2-Chlorovinyl Phosphate; Diethyl 2-Chloro-l-
(2,4-Dichlorophenyl)Vinyl Phosphate; ENT 24969; GC 4072; GS 4072; QMS 1328;
Phosphoric Acid, 2-Chloro-l-(2,4-Dichlorophenyl)Ethenyl Diethyl Ester;
Phosphoric Acid, 2-Chloro-l-(2,4-Dichlorophenyl)Vinyl Diethyl Ester; Sapecron;
SD 4072; Shell 4072; Supone; Vinyphate
Chemical Formula: C12H14C13O4P
Molecular Weight: 359.56
SECTION I ~ REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(rat) 10 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 333-338°F, 167-170°C at 0.5 mmHg (*Worthing 1979)
Specific Gravity (H2O=1): 1.36 at 15.5°C/16.5°C (*Worthing 1979)
Vapor Pressure (mmHg): 0.000004 at 20°C (*Worthing 1979)
Melting Point: -2 to -9°F; -19 to -23°C (*Worthing 1979)
-------
CAS Registry Number: 470-90-6
Page 2 of 4
CHLOkf LNVINFOS
SECTION I (continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 145 mg/liter at 23°C (*Worthing 1979).
Appearance and Odor: Amber-colored liquid with mild chemical odor
(*Worthing 1979; *Spencer 1973).
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) (DOT 1984,
Guide 55)
Skin: Yes (Hayes 1982, p. 396)
Ingestion: Yes (Hayes 1982, pp. 396-97)
Health Hazards (Acute, Delayed, and Chronic): Acute: cholinesterase
inhibitor which affects central nervous system. Severe illness or death
possible (Hayes 1982, pp. 396-397). Convulsions or coma and death
(*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorus Pesticide,
Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific — Organophosphorus
Pesticide, Liquid, n.o.s.) Move container from fire area if you can do it
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material. Wear positive pressure
breathing apparatus and special protective clothirr- ^DOT 1984, Guide 55).
-------
CAS Registry Number: 470-90-6
Page 3 of 4
CHLORFENVINFOS
SECTION IV (continued)
Unusual Fire and Explosion Hazards: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) This material may burn but does not ignite
readily. Container may explode in heat of fire. Fire and runoff from fire
control water may produce irritating or poisonous gases (DOT 1984, Guide
55).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes, when stored in glass or polyethylene lined
containers (*Worthing 1979)
Conditions to Avoid: Alkaline aqueous solutions (*Merck 1976)
Incompatibility (Materials to Avoid): Iron, steel, and brass (*Worthing
1979).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Used for control of ticks, flies, lice, and mites on cattle and for
blowfly, lice, ked, and itchmite on sheep (*Farm Chemicals Handbook 1980).
Controls fleas and mites on dog; do not use on cats. Used on organic
wastes and breeding places of fly larvae, including diary barns (*Rossoff
1974; Hayes 1982, p. 396). Also used as a foliage insecticide for
potatoes, rice, maize, and sugar cane. Used to control soil insects, i.e.,
rootflies, rootworms, and cutworms (*Spencer 1973).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific — Organophosphorus Pesticide, Liquid, n.o.s.) In case of
spill or leak, do not touch spilled material; stop leak if you can do it
without risk. Use water spray to reduce vapors. Small spills: take up
with sand or other non-combustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal. Keep unnecesary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces before
entering them. Remove and isolate contaminated clothing at the site
(DOT 1984, Guide 55).
-------
CAS Registry Number: 470-90-6
Page 4 of 4
CHLORFENVINFOS
SECTION VIII -- PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Butyl/Neoprene GOOD/LIMITED**
Viton/Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Symptoms typical of cholinesterase
poisoning. Nausea is often first symptom, with vomiting, abdominal cramps,
diarrhea, and excessive salivation. Headache, giddiness, weakness,
tightness in chest, blurring of vision, pinpoint pupils, loss of muscle
coordination, and difficulty breathing. Convulsions and coma precede death
(*Gosselin 1976).
Emergency and First Aid Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If breathing
is difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 502-39-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - METHYLMERCURIC DICYANAMIDE
CAS Registry Number: 502-39-6
Synonyms: (Cyanoguanidino)Methylmercury; Agrosol; Cyano(Methylmercuri)
Guanidine; Guanidine, Cyano(Methylmercurio)-; Guanidine, Cyano-, Methylmercury
Deriv; Mercury, (3-Cyanoguanidino)Methyl-; Mercury, (Cyanoguanidinato)Methyl-;
Mercury, (Cyanoguanidinato-N')Methyl-; Methyl Mercuric Dicyandiamide;
Methylmercuric Cyanoguanidine; MMD; Morsodren; Morton EP-227; Morton Soil
Drench; Morton Soil-Drench-C; N-Cyano-N'-(Methyl-mercury)Guanidine;
Pano-Drench; Pano-Drench 4; Panodrin A-13; Panogen; Panogen 15;
Panogen 43; Panogen 8; Panogen PX; Panogen Turf Spray; Panogen (Old);
Panospray 30; R 8; R 8 (Fungicide); MEMA; Methylmercuric Dicyandiamide;
Methylmercury dicyandiamide; Panogen Turf Fungicide
Chemical Formula: CsH6HgN4
Molecular Weight: 298.72
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(mouse) 20 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): In Mercury Compounds category
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): 0.000065 at 35°C (*Martin and Worthing 1974)
Melting Point: 313°F, 156°C (*Hawley 1981)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 502-39-6
Page 2 of 4
METHYLMERCURIC DICYANAMIDE
SECTION II (continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 2.17 g/100 ml at room temperature (*Martin and
Worthing 1974); soluble (Hawley 1981, p. 295)
Appearance and Odor: Crystals (*Hawley 1981)
SECTION III - HEALTH HAZARD DATA
OSHA PEL: TWA 0.01 mg/m3; ceiling concentration 0.04 mg/m3
(NIOSH/RTECS 1983, Volume 2, p. 662)
ACGIH TLV: TWA 0.01 mg (Hg)/m3; STEL (ceiling) 0.03 mg (Hg)/m3 (skin)
(NIOSH/RTECS 1983, Volume 2, p. 662)
IDLH: Not Found
<
Other Limits Recommended: IDLH for organo (alkyl) mercury compounds is 10
mg/m3 (NIOSH/OSHA 1978, p. 144).
Routes of Entry: Inhalation: Yes (Gosselin 1984, p. 11-137)
Skin: Yes (Gosselin 1984, p. II-137)
Ingestion: Yes (Sax 1984, p. 1868)
Health Hazards (Acute, Delayed, and Chronic): Methylmercuric dicyanamide
is extremely toxic to humans. The probable lethal dose for humans is 5-50
mg/kg of body weight (between 7 drops and one teaspoon for a 150 Ib.
person) (*Gosselin 1984). Humans may be poisoned by feeding on the flesh
of animals which have ingested this fungicide (*Clark 1981). Eating
treated seeds may also cause poisoning. The poisoning may show delayed
manifestations on the nervous system. Patients frequently become gradually
worse after their illness is recognized and exposure is stopped (Hayes,
1982, p. 21). This compound is a strong skin irritant and produces
blisters and other dermatitis (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Mercury-Based Pesticide, n.o.s.)
This material may burn but will not ignite readily. For small fires, use
dry chemical, carbon dioxide, water spray, or foam. For large fires, use
water spray, fog, or foam (DOT 1984, Guide 55).
-------
CAS Registry Number: 502-39-6
Page 3 of 4
METHYLMERCURIC DICYANAMIDE
SECTION IV (continued)
Special Fire Fighting Procedures: (Non-Specific -- Mercury-Based
Pesticide, n.o.s.) Fight fire from maximum distance. Dike fire control
water for later disposal. Wear positive pressure breathing apparatus and
special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific — Mercury-Based
Pesticide, n.o.s.) This material may burn but does not ignite readily.
Container may explode in heat of fire. Fire and runoff from fire control
water may produce irritating or poisonous gases (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
SECTION V - REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Martin and Worthing 1974)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits very toxic fumes of mercury and nitrogen oxides (Sax 1984, p. 1868).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Fungicide; a seed, soil, and turf treatment (Buchel 1983, p. 249)
especially for cereals, sorghum, sugar beets, cotton, and flax (Hayes 1982,
p. 20). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index
1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Mercury-Based Pesticide n.o.s.) Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Ventilate closed spaces before entering. Remove and isolate
contaminated clothing at the site. Do not touch spilled material. Use
water to reduce vapors. In event of spill or leak: take up with absorbent
material and place in containers with covers. Small dry spill:
with clean shovel place material into clean, dry container and cover;
move containers from spill area. Dike far ahead of spill if large
(DOT 1984, Guide 55).
-------
CAS Registry Number: 502-39-6
Page 4 of 4
METHYLMERCURIC DICYANAMIDE
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Prolonged exposure to skin may produce
. blisters (*Gosselin 1984). In the case of ingestion there is nausea and
abdominal pain. Vomiting and diarrhea may occur. Burning or prickling of
the lips, tongue, and extremities. The patient may be confused,
hallucinate, be irritable, have disturbed sleep, lose muscular coordination
and lose memory. Visual fields may narrow concentrically; emotional
instability may occur as well as inability to concentrate, with stupor and
coma (*Rumack 1975 to Present).
Emergency and First Aid Procedures: (Non-Specific -- Mercury-Based
Pesticide, n.o.s.) Move victim to fresh air; call emergency medical care.
If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 504-24-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- PYRIDINE, 4-AMINO-
CAS Registry Number: 504-24-5
Synonyms: 4-Aminopyridine; 4-AP; 4-Pyridinamine; 4-Pyridylamine; Amino-4
Pyridine; Avitrol; gamma-Aminopyridine; MI-W-3; p-Aminopyridine; Phillips 1861;
VMI 10-3
Chemical Formula: CEH6N2
Molecular Weight: 94.13
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(rat) 20 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1000 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: 524.3°F, 273.5°C (*Hawley 1977)
Specific Gravity (H2O=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 318.0°F, 158.9°C (*Hawley 1977)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Moderately soluble (*Farm Chemicals Handbook 1981)
Appearance and Odor: White crystalline material with no odor (*Farm
Chemicals Handbook 1981).
-------
CAS Registry Number: 504-24-5
Page 2 of 4
PYRIDINE, 4-AMINO-
SECTION III -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Material may be fatal if
inhaled, swallowed or absorbed through skin. Contact may cause burns to
skin and eyes (*DOT 1984). Material affects neural transmission. In
sufficient concentrations, material may cause metabolic acidosis,
respiratory arrest, and cardiac arrhythmias (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: The material may burn but will not ignite easily.
To extinguish use dry chemical, carbon dioxide, water spray, fog, or foam
(DOT 1984, Guide 55).
Special Fire Fighting Procedures: Wear positive pressure self-contained
breathing apparatus and special protective clothing. Move container from
fire area if you can do so without risk. Fight fire from maximum distance
possible. Control runoff water with dikes and prevent material from
scattering (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Material may produce irritating or
poisonous gases in fire. Runoff from fire control water may give off
poisonous gases (DOT 1984, Guide 55).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Farm Chemicals Handbook 1981)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
-------
CAS Registry Number: 504-24-5
Page 3 of 4
PYRIDINE, 4-AMINO-
SECTION V (continued)
Hazardous Decomposition or Byproducts: It may emit irritating or
poisonous gases in fire conditions (DOT 1984, Guide 55).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
SECTION VI -- USE INFORMATION
Material is used as an avicide (bird repellant), an intermediate and as a
fixer in some textile dyes (*Rumack 1975 to Present, *Hawley 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate the hazardous area and deny entry.
Stay upwind. Do not touch spilled material; stop leak if possible
without risk. Use water spray to reduce vapors. Small spills: absorb
with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel place
material into clean, dry container and cover; move containers from spill
area. Large spills: dike far ahead of spill for later disposal (*DOT
1984).
SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Nitrile POOR/LIMITED**
PVC POOR/LIMITED**
Viton GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Rapid onset of disagreeable taste,
immediate burning of throat, and abdominal discomfort; in addition,
weakness, dizziness, disorientation, and seizures may occur. Delayed
symptoms of oral ingestion include elevated liver enzymes, and respiratory
arrest (*Rumack 1975 to Present).
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CAS Registry Number: 504-24-5
Page 4 of 4
PYRIDINE, 4-AMINO-
SECTION IX (continued)
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If breathing is difficult, give oxygen. In case
of contact with material, immediately flush skin or eyes with running water
for at least fifteen minutes (*DOT 1984).
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CAS Registry Number: 505-60-2
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - MUSTARD GAS
CAS Registry Number: 505-60-2
Synonyms: Sulfide, bis(2-Chloroethyl); l,l'-Thiobis(2-Chloroethane);
1 -Chloro-2-(beta-Chloroethylthio)Ethane; 2,2'-Dichlorodiethyl Sulfide;
2,2'-Dichlorodiethyl Sulphide; 2,2'-Dichloroethyl Sulfide; 2,2'-Dichloroethyl
Sulphide; beta, beta'-Dichloroethyl Sulfide; beta, beta'-Dichloroethyl
Sulphide; beta,beta-Dichlor-Ethyl-Sulphide; Bis(2-Chloroethyl) Sulfide;
Bis(2-Chloroethyl) Sulphide; Bis(beta-Chloroethyl) Sulfide;
Bis(beta-Chloroethyl) Sulphide; Di-2-Chloroethyl Sulfide; Di-2-Chloroethyl
Sulphide; Distilled Mustard; Ethane, l,l'-Thiobis(2-Chloro-; H; HD; Kampfstoff
"Lost"; Mustard HD; Mustard Vapor; Mustard, Sulfur; S Mustard; S-Lost;
S-Yperite; Schwefel-Lost; Sulfur Mustard; Sulfur Mustard Gas; Sulphur Mustard;
Sulphur Mustard Gas; Yellow Cross Liquid; Yperite
Chemical Formula: C4H8C12S
Molecular Weight: 159.08
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC50 inhalation
(rat) 0.42 mg/liter/2 minutes (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): Yes
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 419-423°F, 215-217°C (*Merck 1976)
Specific Gravity (H2O=1): 1.274 at 20°C/4°C (liquid) (*Merck 1976)
Vapor Pressure (mmHg): 0.090 at 30°C (*Merck 1976)
Melting Point: 55-57°F, 13-14°C (*Merck 1976)
Vapor Density (AIR=l):-~5.4 (*Sax 1975)
-------
CAS Registry Number: 505-60-2
Page 2 of 4
MUSTARD GAS
SECTION II (continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.68 g/liter at 25°C (*IARC 1972-1985); very
sparingly soluble in water (Merck 1983, p. 904).
Appearance and Odor: Colorless oily liquid (*IARC 1972-1985) with a weak,
sweet odor (*Merck 1976) or garlic-like odor (U.S. Army 1975, p. 3-8).
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): The median lethal dosage is
1500 mg-minute/m3 for inhalation and 10,000 mg-minute/ms for skin
absorption (masked personnel). The median incapacitating dosage is 200
mg-minute/m3 for eye injury and 2000 mg-minute/ms for skin absorption
(masked personnel). Wet skin absorbs more material than dry skin (U.S.
Army 1975, p. 3-8). May cause death or permanent injury after very short
exposure to small quantities (*Sax 1975). It is a blistering gas and is
highly irritating to eyes, skin, and lungs. Pulmonary lesions are often
fatal (Sax 1984, pp. 461-462). Permanent eye damage and severe respiratory
impairment. It is a carcinogen (Merck 1983, p. 904).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 221°F, 105°C (*Sax 1975)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with water, foam, dry chemical, or
carbon dioxide (*Sax 1975).
Special Fire Fighting Procedures: Protective clothing and self-contained
breathing apparatus required in presence of mustard g?' '*Sax 1975). Cool
all affected containers with flooding quantities of ^ .-..pply water
from as far a distance as possible (Student 1981, p
-------
CAS Registry Number: 505-60-2
Page 3 of 4
MUSTARD GAS
SECTION IV (continued)
Unusual Fire and Explosion Hazards: Can be ignited by large explosive
charge. When heated to decomposition, emits highly toxic fumes of oxides
of sulfur and chlorine containing compounds. Reacts with water or steam to
produce toxic and corrosive fumes (*Sax 1975). Containers may rupture
violently in a fire (Student 1981, p. 358).
NFPA Flammability Rating: Not Found
SECTION V -- REACTIVITY DATA
Stability: Unstable: Yes; hydrolyzed in aqueous solution (*IARC
1972-1985)
Stable:
Conditions to Avoid: High heat; contact with acid or acid fumes (*Sax
1984, p. 482).
Incompatibility (Materials to Avoid): Incompatible with bleaching powder
(Sax 1984, p. 482). Reacts violently with oxidizing materials. Reacts
with water or steam to produce toxic and corrosive fumes (*Sax 1975).
Hazardous Decomposition or Byproducts: Emits highly toxic fumes of oxides
of sulfur and chlorine containing compounds when heated to decomposition or
on contact with acid or acid fumes (*Sax 1974)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
It has been used as a chemical warfare agent (*IARC 1972-1985) and as a
chemical intermediate. It is not produced commercially in the U.S. (*SRI).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
To clean up a spill, cover with up to 15 percent calcium hypochloride.
Place in container; neutralize after 12 hours if necessary (*Rumack 1975 to
Present). Keep sparks, flames, and other sources of ignition away. Keep
material out of water sources and sewers. Attempt to stop leak if without
hazard. Use water spray to knock down vapors. Avoid breathing vapors and
bodily contact with the material. Keep upwind. Wash away any material
which may have contacted the body with copious amounts of soap and water.
Downwind evacuation must be considered (Student 1981, p. 358).
-------
CAS Registry Number: 505-60-2
Page 4 of 4
MUSTARD GAS
SECTION VIII ~ PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: May cause conjunctivitis and blindness.
In 1-12 hours there may be coughing, swollen eyelids, reddened skin, and
severe itching. There may be swelling and destruction of tissue in the
respiratory tract and exposed skin. Ingestion may cause nausea and
vomiting (*Merck 1976).
Emergency and First Aid Procedures: Remove patient from contaminated
atmosphere as rapidly as possible. Irrigate exposed eyes with water for at
least 15 minutes. Wash exposed areas of the skin twice with soap and
water. Local lesions should be cleaned and treated similarly to burns with
emollients (*Rumack 1975 to Present).
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CAS Registry Number: 506-61-6
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- POTASSIUM SILVER CYANIDE
CAS Registry Number: 506-61-6
Synonyms: Argentate(l-), bis(Cyano-C)-, Potassium; Argentate(l-), Dicyano-,
Potassium; Argentates(I) (Sol), Dicyano-; Potassium Argentocyanide; Potassium
bis(Cyano-C)Argentate(l-); Potassium Dicyanoargentate; Potassium
Dicyanoargentate (KAg(CN)2); Potassium Dicyanoargentate(l-); Potassium
Dicyanoargentate(I); Potassium Silver Cyanide (KAg(CN)2); Silver Potassium
Cyanide [AgK(CN)2]
Chemical Formula: C2AgN2'K
Molecular Weight: 199.01
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LD50 oral
(rat) 21 mg/kg (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 1 (pounds)
Section 313 Listed (Yes or No): In Cyanide Compounds and Silver
Compounds categories
SECTION II ~ PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 2.36 at 25°C (*Hawley 1977)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Merck 1976)
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CAS Registry Number: 506-61-6
Page 2 of 4
POTASSIUM SILVER CYANIDE
SECTION II (continued)
Appearance and Odor: White crystals (*Merck 1976)
SECTION HI -- HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: (Cyanides) TWA 5 mg/ms, as cyanide (skin) (AGCIH 1986-87, p.14)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): The primary health hazard
is as a cyanide (*Gosselin 1976). (Non-specific -- Cyanide, Inorganic,
n.o.s.). It is poisonous and may be fatal if inhaled, swallowed or
absorbed through the skin. Fire may produce irritating or poisonous gases
(DOT 1984, Guide 55).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV « FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific — Cyanide, Inorganic, n.o.s.) Use
dry chemical, carbon dioxide, water spray, or foam for small fire, and
water spray, fog, or foam for large fires. Move containers of this
material away from fire area if this can be done without risk (DOT 1984,
Guide 55).
Special Fire Fighting Procedures: (Non-Specific — Cyanide, Inorganic,
n.o.s.) Isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Ventilate closed spaces before entering them. Wear positive
pressure breathing apparatus and special protective clothing. Fight fire
from maximum distance. Dike fire control water for later disposal. Do not
scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition,
potassium silver cyanide emits very toxic fumes of cyanide and nitrogen
oxides (Sax 1984, p. 2282).
NFPA Flammability Rating: Not Found
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CAS Registry Number: 506-61-6
Page 3 of 4
POTASSIUM SILVER CYANIDE
SECTION V - REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Light (*Merck 1976)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
potassium silver cyanide emits very toxic fumes of cyanide and nitrogen
oxides (Sax 1984, p. 2282).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Potassium silver cyanide is used in silver plating, as a bactericide
(*Merck 1976), and in the manufacture of antiseptics (*Hawley 1977). Not
registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation or skin contact (see Section III above). (Non-Specific --
Cyanide, Inorganic, n.o.s.) Do not touch spilled materials; stop leak if
you can do so without risk. Use water spray to reduce vapors. Small
spills: absorb with sand or other noncombustible absorbent material and
place into containers for later disposal. Small dry spills: with clean
shovel place material into clean, dry container and cover; move containers
from spill area. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
Neoprene GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
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CAS Registry Number: 506-61-6
Page 4 of 4
POTASSIUM SILVER CYANIDE
SECTION IX - EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: As a cyanide, massive doses may produce,
without warning, sudden loss of consciousness and prompt death from
respiratory arrest. Smaller but still lethal doses result in illness that
may be prolonged for 1 or more hours. Other symptoms may include numbness
in throat, salivation, nausea, anxiety, dizziness, irregular breathing,
odor of bitter almonds may be noted on breath, blood pressure may rise,
slowing of the heart beat, sensation of constriction in the chest,
unconsciousness followed by violent convulsions and paralysis (*Gosselin
1976).
Emergency and First Aid Procedures: (Non-Specific -- Cyanide, Inorganic,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 55).
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CAS Registry Number: 506-68-3
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - CYANOGEN BROMIDE
CAS Registry Number: 506-68-3
Synonyms: Bromine Cyanide; Bromocyan; Bromocyanide; Bromocyanogen; Campilit;
Cyanobromide; Cyanogen Monobromide; TL 822
Chemical Formula: CBrN
Molecular Weight: 105.93
SECTION I ~ REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LClow inhalation
(human) 0.398 mg/liter/10 minutes (*NIOSH/RTECS 1985)
TPQ: 500/10,000 (pounds)
RQ: 1000 (pounds)
Section 313 Listed (Yes or No): No
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: 142°F, 61.4°C (*Weast 1979)
Specific Gravity (H2O=1): 2.015 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 92 at 20°C (*Patty 1963)
Melting Point: 126°F, 52°C (*Merck 1976)
Vapor Density (AIR=1): 3.62 (*Patty 1963)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Weast 1979)
Appearance and Odor: Colorless to white cubes or needle-like crystals
with a penetrating odor (*Merck 1976; *Sax 1979; *NFPA 1978; *Patty 1963)
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CAS Registry Number: 506-68-3
Page 2 of 4
CYANOGEN BROMIDE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: (Cyanides) TWA 5mg/m3, as cyanide (skin) (ACGIH 1986-87, p. 14)
IDLH: Not Found
Other Limits Recommended: Suggested TLV less than 0.5 ppm (*Patty 1963).
Routes of Entry: Inhalation: Yes (*NIOSH 1979)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Super toxic; probable oral
lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops)
for a 70 kg (150 Ib.) person (*Gosselin 1976). Vapors are highly irritant
and very poisonous (*Merck 1976).
Medical Conditions Generally Aggravated by Exposure: Individuals with
chronic diseases of the kidneys, respiratory tract, skin, or thyroid are at
greater risk of developing toxic cyanide effects (*Encyc Occupat Health and
Safety 1983).
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Noncombustible (NFPA 1978, p. 49-34)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish fire using agent suitable for type of
surrounding fire. Material itself does not burn or burns with difficulty.
Use foam, carbon dioxide, or dry chemical. Cool all affected containers
with flooding quantities of water. Do not use water on material itself.
If large quantities of combustibles are involved, use water in flooding
quantities as spray and fog. Use water spray to absorb vapors. Keep
material out of water sources and sewers. Use water spray to knock down
vapors (Student 1981, p. 158).
Special Fire Fighting Procedures: Wear full protective clothing. Avoid
direct water contact as it will cause cyanogen bromide to decompose,
releasing toxic gases (*NFPA 1978). Avoid breathing vapors or dusts; keep
upwind; wear self-contained breathing apparatus (Student 1981, p. 158).
Unusual Fire and Explosion Hazards: Cyanogen bromide is not combustible
itself, but impure cyanogen bromide decomposes rapidly and tends to explode
(*Merck 1976). A violent reaction may take place on contact with large
quantities of acid (*NFPA 1978). Vapors are highly irritating (*Merck
1976).
NFPA Flammability Rating: 0
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CAS Registry Number: 506-68-3
Page 3 of 4
CYANOGEN BROMIDE
SECTION V - REACTIVITY DATA
Stability: Unstable: Yes, impure material decomposes rapidly and tends
to explode (*Merck 1976)
Stable:
Conditions to Avoid: Avoid physical damage, contact with acids or
water, and store away from a location where water may be needed for
fire control (*NFPA 1978).
Incompatibility (Materials to Avoid): Water, acids (*NFPA 1978)
Hazardous Decomposition or Byproducts: When material is heated to
decomposition, it emits very toxic fumes of cyanide and bromide (Sax 1984,
p. 825).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI -- USE INFORMATION
Cyanogen bromide is used in organic synthesis, as a fumigant, a pesticide,
in cellulose technology, and in gold-extraction (*Patty 1963). Not
registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do it without
risk. Use water spray to reduce vapors. Small spills: take up
with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SUIT MATERIAL PERFORMANCE (Based on EPA/USCG "Guidelines", 1987)
(Chemical Resistance/Amount of Data)
CPE GOOD/LIMITED**
*Based on qualitative performance information.
**Based on a chemical analog.
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CAS Registry Number: 506-68-3
Page 4 of 4
CYANOGEN BROMIDE
SECTION IX -- EMERGENCY TREATMENT INFORMATION
See Emergency First Aid Treatment Guide
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EFATG
CAS Registry Number: 506-68-3
Page 1 of 3
Emergency First Aid Treatment Guide
for
CYANOGEN BROMIDE
(506-68-3)
This guide should not be construed to authorize emergency personnel to
perform the procedures or activities indicated or implied. Care of persons
exposed to toxic chemicals must be directed by a physician or other recognized
authority.
Caution: Cyanogen bromide toxicity can occur via ingestion, dermal/eye
contact, or inhalation; death may occur within minutes. IMMEDIATELY begin
administering 100% oxygen and RUSH victims to a health care facility!
Substance Characteristics:
Pure Forms - White cubes or needlelike crystals.
Odor - Penetrating.
Commercial Form - 97% pure solid.
Uses - Fumigant, chemical intermediate.
Materials to Avoid - Acids, water (except for use in emergency life support).
Other Names - Bromine cyanide, Bromocyan, Cyanobromide, TL-822.
Personal Protective Equipment: See Chemical Profile Section VIII.
Emergency Life-Support Equipment and Supplies That May Be Required:
Compressed oxygen, forced-oxygen mask, soap, water, activated charcoal, saline
cathartic or sorbitol, normal saline, D5W, Ringer's lactate, cyanide antidote
kit (amyl nitrite ampule, sodium nitrite, sodium thiosulfate), sodium
bicarbonate, diazepam, phenytoin.
Signs and Symptoms of Acute Cyanogen Bromide Exposure:
Warning: Cyanogen bromide may be fatal if inhaled, swallowed, or absorbed
through skin or mucous membranes. Caution is advised.
Signs and symptoms of acute exposure to cyanogen bromide may include
hypertension (high blood pressure) and tachycardia (rapid heart rate), followed
by hypotension (low blood pressure) and bradycardia (slow heart rate). Cherry-
red or bloody mucous membranes may be noted. Cardiac arrhythmias and other
cardiac abnormalities are common. Cyanosis (blue tint to the skin and mucous
membranes) may be observed,?
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EFATG
CAS Registry Number: 506-68-3
Page 2 of 3
CYANOGEN BROMIDE
Headache, vertigo (dizziness), agitation, and giddiness may be followed by
combative behavior, convulsions, paralysis, protruding eyeballs, dilated and
unreactive pupils, and coma. Tachypnea (rapid, shallow respirations) or
hyperpnea (rapid, deep respirations) may be followed by respiratory depression.
Lung hemorrhage and pulmonary edema may also occur.
Cyanogen bromide is irritating to the skin, eyes, and mucous membranes.
Lacrimation (tearing) and a burning sensation of the mouth and throat are
common. Salivation, nausea, and vomiting may also occur.
Emergency Life-Support Procedures:
Acute exposure to cyanogen bromide may require decontamination and life support
for the victims. All exposed persons should be transported to a health care
facility as quickly as possible. Emergency personnel should wear protective
clothing appropriate to the type and degree of contamination. Air-purifying or
supplied-air respiratory equipment should also be worn, as necessary. Rescue
vehicles should carry supplies such as plastic sheeting and disposable plastic
bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure
to cyanogen bromide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use
a forced-oxygen mask. Direct oral contact with cyanogen bromide-
contaminated persons or their gastric contents can result in self-
poisoning.
3. RUSH to a health care facility!
4. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-
exposure to cyanogen bromide.
2. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin : , - ristering 100% oxygen to
all victims. Monitor victims for respiratory cL
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EFATG
CAS Registry Number: 506-68-3
Page 3 of 3
CYANOGEN BROMIDE
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use
a forced-oxygen mask. Direct oral contact with cyanogen bromide-
contaminated persons or their gastric contents can result in self-
poisoning.
3. RUSH to a health care facility!
4. Remove contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for
at least 15 minutes.
6. Wash exposed skin areas twice with soap and water.
7. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any
trauma. If no pulse is detected, provide CPR. If not breathing, provide
artificial respiration. IMMEDIATELY begin administering 100% oxygen to
all victims. Monitor victims for respiratory distress.
Warning: To prevent self-poisoning, avoid mouth-to-mouth breathing; use
a forced-oxygen mask. Direct oral contact with cyanogen bromide-
contaminated persons or their gastric contents can result in self-
poisoning.
2. RUSH to a health care facility!
3. Obtain authorization and/or further instructions from the local hospital
for administration of an antidote or performance of other invasive
procedures.
4. DO NOT induce vomiting or attempt to neutralize!
5. Activated charcoal may be administered if victims are conscious and alert.
Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz)
for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to
conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz)
of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
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CAS Registry Number: 506-78-5
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY -- CYANOGEN IODIDE
CAS Registry Number: 506-78-5
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 545): Iodine Cyanide;
Jodcyan
Chemical Formula: CIN
Molecular Weight: 152.92
SECTION I -- REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LDlow oral
(cat) 18 mg/kg (*NIOSH/RTECS 1985)
TPQ: 1,000/10,000 (pounds)
RQ: 1 (pounds)
(statutory, for notification under SARA Section 304(a)(2))
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Boiling Point: Not Found
Specific Gravity (H2O=1): 2.84 (Hawley 1981, p. 295)
Vapor Pressure (mmHg): 1 at 25.2°C (Sax 1984, p. 826)
Melting Point: 295.7°F, 146.5°C (Hawley 1981, p. 295)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly (Weast 1980, p. C-259)
Appearance and Odor: White needles with a very pungent odor (Merck 1983,
p. 385).
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CAS Registry Number: 506-78-5
Page 2 of 4
CYANOGEN IODIDE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: Not Found
ACGIH TLV: (Cyanides) TWA 5.0 mg/m8, as cyanide (skin) (ACGIH 1986-87,
P. 14)
IDLH: Not Found
Other Limits Recommended: Not Found
Routes of Entry: Inhalation: No (Merck 1983, p. 385)
Skin: Yes (Sax 1984, p. 826, p. 822)
Ingestion: Yes (Sax 1984, p. 826, p. 822)
Health Hazards (Acute, Delayed, and Chronic): Causes convulsions,
paralysis and death from respiratory failure (Merck 1983, p. 385). Highly
toxic; strong irritant to eyes and skin (Hawley 1981, p. 295).
(Non-Specific -- Cyanide or Cyanide Mixture, Dry): Poisonous, may be fatal
if swallowed or absorbed through skin. Contact may cause burns to the skin
and eyes. Fire may produce irritating or poisonous gases (DOT 1984, Guide
55).
Medical Conditions Generally Aggravated by Exposure: Not Found
SECTION IV - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Cyanide or Cyanide Mixture, Dry)
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large
fires: water spray, fog, or foam. Move container from fire area if you
can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
Special Fire Fighting Procedures: (Non-Specific - Cyanide or Cyanide
Mixture, Dry) Keep unnecessary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces before
entering them. Wear positive pressure breathing apparatus and special
protective clothing. Remove and isolate contaminated clothing at the site
(DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of nitrogen oxides, cyanide, and iodide (Sax 1984,
p. 826).
NFPA Flammability Rating: Not Found
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CAS Registry Number: 506-78-5
Page 3 of 4
CYANOGEN IODIDE
SECTION V -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Phosphorus (Sax 1984, p. 826)
Hazardous Decomposition or Byproducts: When heated to decomposition, it
emits very toxic fumes of nitrogen oxides, cyanide, and iodide (Sax 1984,
p. 826).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION VI - USE INFORMATION
Taxidermists' preservatives (Hawley 1981, p. 295). Generally for
destroying all lower forms of life (Merck 1983, p. 385).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Cyanide or Cyanide Mixture, Dry) Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Small dry
spills: with clean shovel, place material into clean, dry container and
cover; move containers from spill area. Large spills: dike far ahead of
spill for later disposal (DOT 1984, Guide 55).
SECTION VIII - PROTECTIVE EQUIPMENT FOR EMERGENCY SITUATIONS
For emergency situations, wear a positive pressure, pressure-demand,
full facepiece self-contained breathing apparatus (SCBA) or pressure-
demand supplied air respirator with escape SCBA and a fully-encapsulating,
chemical resistant suit. See the introductory information section at the
beginning of the profiles for additional information.
SECTION IX -- EMERGENCY TREATMENT INFORMATION
Signs and Symptoms of Exposure: Can cause death due to respiratory
failure (Merck 1983, p. 385). Health effects are similar to cyanides and
iodides (Sax 1984, p. 826). Upon ingestion, a bitter, acrid, burning taste
is sometimes noted. Other symptoms are anxiety, confusion, dizziness,
giddiness, rapid and difficult breathing, palpitations, tightness in chest,
unconsciousness, violent convulsions and death (Gosselin 1984, p. HI-127).
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CAS Registry Number: 506-78-5
Page 4 of 4
CYANOGEN IODIDE
SECTION IX (continued)
Emergency and First Aid Procedures: (Non-Specific -- Cyanide or Cyanide
Mixture, Dry) Move victim to fresh air; call emergency medical care. If
not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
COMMENTS
Sources searched but no information found:
NIOSH/OSHA 1978
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Encyc Occupat Health and Safety. 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
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CAS Registry Number: 509-14-8
Page 1 of 4
EPA CHEMICAL PROFILE
Date: October 31, 1985
Revision: November 30, 1987
CHEMICAL IDENTITY - TETRANITROMETHANE
CAS Registry Number: 509-14-8
Synonyms: Methane, Tetranitro; NCI-C55947; Tetan; TNM
Chemical Formula: CN4O8
Molecular Weight: 196.04
SECTION I - REGULATORY INFORMATION
CERCLA (SARA) 1986:
Toxicity Value Used for Listing Under Section 302: LC60 inhalation
(rat) 0.144 mg/liter/4 hours (*NIOSH/RTECS 1985)
TPQ: 500 (pounds)
RQ: 10 (pounds)
Section 313 Listed (Yes or No): No
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Liquid
Boiling Point: 259°F, 126°C (*Merck 1976)
Specific Gravity (H2O=1): 1.6380 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 13 at 25°C (*Patty 1963)
Melting Point: 57.6°F, 14.2°C (*Weast 1979)
Vapor Density (AIR=1): 6.8 (*Patty 1963)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Weast 1979)
Appearance and Odor: Pale yellow liquid (*Merck 1976) or colorless oily
fluid with acrid biting odor (*Patty 1963), causes tears (NIOSH/OSHA 1978,
p. 178).
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CAS Registry Number: 509-14-8
Page 2 of 4
TETRANITROMETHANE
SECTION III - HEALTH HAZARD DATA
OSHA PEL: T |