OERR 9200.6-303 (92-2)
                540R92101
   United States
   Environmental Protection
   Agency
OSWER (OS-230)
ORD (RD-689)
OERR 9200.6-303 (92-2)
NT1S NO. PB92-321199A
July 1992
  Health Effects Assessment Summary Tables
  Supplement A
                                              ...BONMENfAi
                                              PROTE«TI®fI
                                                AGEN«Y

                                              DALLAS; TEXAS

-------
&EPA
                Unrtad SIMM
                Cnvironmanul Protaction
Off •«• of Emargancy «nd
flamadial Rasponaa
WMnington DC 20*60
Offica of Rttttrch and 0»v*lopmtnt
   of H«»Uh and Envirenmantal
                                              Envirenmantal Critaria and
                                              . Auaumam OHica
                                              Cincinnati OH 45268
                Suparfund
                July 1992
               HEALTH  EFFECTS ASSESSMENT
               SUMMARY TABLES
               Supplement No. 1 to  the
               March  1992  Annual Update

-------
, t
                                                 OHEA ECAO-CIN-821
                                                         July 1992
                     HEALTH EFFECTS ASSESSMENT

                          SUMMARY TABLES


                     FY-1992 Supplement No. 1
                Office of Research and Development
             Office  of Emergency  and  Remedial  Response
               U.S.  Environmental Protection Agency
                       Washington,  DC  20460

-------
                            DISCLAIMER


     This  report has  been  prepared  by  the U.S.  Environmental
Protection Agency.  The information contained herein has been taken
from final documents prepared by the Office of Health and Environ-
mental Assessment  for the  Office of  Solid Waste and  Emergency
Response and the Office of Water,  Washington, DC and the Office of
Air Quality  Planning and Standards,  Research Triangle  Park,  NC.
These documents were reviewed in accordance with Agency policy and
approved for publication.   Mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
                                11

-------
                        TABLE OF CONTENTS

                                                             Page
INTRODUCTION  	     1

WHAT'S NEW IN THE ANNUAL FY92 HEAST	     9

HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)  	    1-1

HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND
CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)  	    2-1

HEAST TABLE 3:  CARCINOGENICITY	    3-1

HEAST TABLE 4A:  RADIONUCLIDE CARCINOGENICITY -  SLOPE
FACTORS (IN PICOCURIES)	4A-1

HEAST TABLE 4B:  RADIONUCLIDE CARCINOGENICITY -  SLOPE
FACTORS (IN. BECQUERELS)	4B-1

REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC
TOXICITY  (OTHER THAN CARCINOGENICITY)      	   Rl-1

REFERENCES FOR HEAST TABLE 2:  ALTERNATE METHODS -
SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)  R2-1

REFERENCES FOR HEAST TABLE 3:  CARCINOGENICITY   	   R3-1
                                111

-------
                           INTRODUCTION







     This document is the July 1992 Supplement No. 1 for the March



1992 Annual Update of the Health Effects Assessment Summary Tables



(HEAST)  prepared by  EPA's  Office  of  Health and  Environmental



Assessment,   Environmental   Criteria   and  Assessment   Office,



Cincinnati,  OH  for use  at  both  Superfund and  RCRA sites.   It



updates the information in the March 1992 HEAST Annual Update and



should  be checked  whenever  that  document is  consulted.   This



supplement was not produced to stand alone and  does not contain the



User's Guides or Appendix that are available in the Annual Update.



Thus, the user must reference the March 1992  HEAST Annual Update



for this  information.  Supplement No. 2  for the  March 1992 HEAST



Annual Update is planned for  release in November 1992.



     The  HEAST  is  a comprehensive  listing  consisting  almost



entirely  of  PROVISIONAL  RISK ASSESSMENT  INFORMATION  relative to



oral and inhalation routes for chemicals of interest to Superfund,



the Resource Conservation and Recovery Act (RCRA),  and the EPA in



general.  These  entries in the HEAST are limited to chemicals that



have undergone review and have the concurrence  of individual Agency



Program  Offices,  and each  is supported by an Agency reference.



This  risk assessment  information  has  not,  however, had enough



review  to be recognized  as  high quality, Agency-wide  consensus



information.



     The Integrated Risk Information System (IRIS) is the Agency's



official repository of Agency-wide consensus chronic human health



risk information.  IRIS evaluations are conducted by the Agency's





                               -1-

-------
Work Group Review process,  i.e.,  they have been examined by either,

the Reference Dose/Reference Concentration  (RfD/RfC) Work Group or

the Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work

Group.  These Agency Work  Groups conduct a process that leads to

internal  Agency  scientific  unanimous  consensus  regarding risk

assessment information on a chemical.  This  information is recorded

on IRIS,  is considered to  be "Work Group Verified",  and does not

appear on the HEAST.  Thus,  provisional risk assessment information

on the HEAST is  subject  to possible review and revision by these

Agency Work Groups.

     There are two exceptions to the above discussion.   The HEAST

also  contains  information on  chemicals that  are  a part  of the

National  Ambient Air Quality  Standards (NAAQS)  or  the Drinking

Water Criteria Document (DWCD)  series.  In each of these cases, the

chemicals are subject to extensive scientific peer review processes

of extremely high quality.



CHEMICAL  STATUS  DEFINITIONS

     Chemicals reviewed  by the Agency Work Groups are classified

according to their status  as either "verified",  "not verifiable",

or "under review".  The toxicity values (other than NAAQS or DWCD

values)  listed  on the HEAST are considered  to be "provisional".

The  Agency  has  no official definitions for  these  terms,  but the

HEAST user may interpret them  as  follows:


     Provisional:   A  toxicity value  or  a  cancer value is
      "provisional" if  the  value has had some form of Agency
     review, but it does  not appear on the IRIS system.  These
     values are  generated  in  several  ways.   Often they are
     determined  in the course of developing an Agency document

                                -2-

-------
     on a chemical or on a class of chemicals.  Some have been
     generated through the Work Group process,  but have not
     yet been  input to the IRIS  system.   At the  time each
     value  was derived,  all  available  information on  the
     chemical was  evaluated, the  value  was calculated using
     the most current methodology, and a  consensus was reached
     on the value by Agency scientists in a program office or
     ORD.


These "provisional" values are  found on the HEAST.  They do not
appear on IRIS.


     Verified:   A  toxicity value  or  a cancer  value is "Work
     Group Verified" if all available information on the value
     has been examined by  an Agency Work Group, the value has
     been calculated using current Work Group methodology, and
     a unanimous consensus has been  reached on  the value by
     the Work Group.


These values have been, or shortly will  be added to IRIS.
Some "verified" numbers may appear on the  HEAST for a short time
until they  are loaded onto IRIS.   During the  interim,  they are
treated as "provisional" values.


     Not verifiable:  A toxicity value is "not verifiable" if
     an Agency  Work Group has considered  all available data on
     a chemical and has unanimously determined that data are
     inadequate to generate a value that  would be suitable for
     inclusion on IRIS.  No toxicity value is  calculated.

No toxicity values are available for  IRIS or the HEAST.  This "not
verifiable" status, however, has been, or shortly will be noted on
IRIS, and is often found on the HEAST, with a  pointer to the IRIS
system.


     Under Review:  A toxicity value is  "under review" if an
     Agency Work Group is in the  process  of considering all
     available data on a chemical.  No conclusions have been
     drawn thus far by the Work Group.   Toxicity values that
     have been withdrawn from IRIS by a  Work Group will have
     this status.

This status may be indicated on IRIS  or on the HEAST.  During this
time, toxicity values "under review" may  appear on the HEAST and
are to be considered "provisional".

     In all cases, the status of a chemical may change as new data

become available, and the assessment is  revisited.

                               -3-

-------
CAUTION
     It is imperative for each user of the HEAST to recognize that
the values listed in the toxicity tables and the cancer table are
generally considered to be PROVISIONAL RISK ASSESSMENT INFORMATION.
The user is referred to  IRIS  for  "Work Group Verified" values.  It
is also  important to remember that  the numbers in  these tables
alone tell very little about the adverse effects of a chemical or
the quality  of  evidence on which  risk  assessment  information is
based.  Original assessment documents must be consulted by users of
the HEAST  in order  to fully  appreciate  the strengths and limita-
tions of  a specific data base.   Original source  documents will
allow for the most complete characterization of potential toxicity
associated with the range of  exposure pathways generally evaluated
at Superfund and RCRA sites.  The Reference Tables point the user
to these sources.

CONTRIBUTORS
     Chemicals  commonly  found at RCRA sites  as identified by the
Office  of Solid  Waste's (OSW)  Technical  Assessment  Branch are
included  in the  HEAST.   The Office of Radiation  Programs has
provided data on radionuclide carcinogenicity for Tables 4A and 4B
of the  HEAST.   The Office of Air Quality  Planning and Standards
(OAQPS) has provided information  on chemicals for which Air Quality
Criteria Documents and National Ambient  Air Quality Standards have
been developed.  The Office  of Water  (OW) has provided information
on chemicals for which Drinking Water Criteria  Documents have been
developed.

                               -4-

-------
CHEMICALS LISTED



     Most of  the chemicals  included  on the toxicity  tables and



carcinogenicity  table  are those  for  which at  least one  of the



following EPA documents has been written:  Health Effects Assess-



ment  Document  (HEA),  Health and  Environmental  Effects  Profile



(HEEP),  Health  and  Environmental  Effects Document (HEED),  Health



Assessment Document  (HAD), Air  Quality Criteria Document (AQCD),



Drinking Water Criteria Document (DWCD).  A description of each is



provided in Appendix A, Section I  of  the March 1992 HEAST Annual



Update.   In a few cases, the  values are supported by other written



material, such as Work Group meeting notes or Carcinogen Assessment



Group (CAG)  Profiles.  Radionuclides included are those believed to



be most commonly encountered at Superfund sites.



     The  names  of  criteria  pollutants  that  are  regulated  as



National Ambient Air Quality  Standards (NAAQS) under the Clean Air



Act are  listed  in  the main body  of the  HEAST,  but  the  actual



criteria  are  included  as  Section V of  Appendix  A:  Technical



Information of the March 1992 HEAST Annual Update.  The NAAQS were



not included  in the tables in order to distinguish  them from the



provisional reference concentration ([RfC]) values.  The NAAQS and



[RfC]s represent different levels of review and different methods



of calculation and thus, must be interpreted and used differently.







HIERARCHY OF SOURCES



     It  is  recognized that  at  any point in  time  there may  be



multiple old  and  new Agency  documents or data bases that present



different values on a specific chemical.  For chemicals other than





                               -5-

-------
those represented by the NAAQS or DWCDs,  the  following hierarchy of

sources  is  recommended  in  evaluating  chemical  toxicity  for

Superfund sites:
     1.  The  Agency's  Integrated Risk  Information  System
         (IRIS) and  cited references.   Changes  are  made in
         this data base on a monthly basis, but there may be
         data gaps.   Call IRIS  USER  SUPPORT at 513/569-7254
         for further information.

     2.  The Health Effects Assessment Summary Tables (HEAST)
         Annual Update and Supplements and cited references.

     3.  Consultation with the  Superfund  Health  Risk Tech-
         nical Support Center (TSC) at (513)569-7300.

     4.  Do not consult either the toxicity tables (Appendix
         A) in the Superfund Public Health Evaluation Manual
         (SPHEM, U.S. EPA, 1986)  or the September 1988 Public
         Health Risk Evaluation Data Base  (PHRED)  as these
         sources are  likely to  contain  numerous values that
         have since become out-of-date.
QUESTIONS

     Chemical Toxicity and Carcinocrenicitv

     Regional EPA  Superfund  Staff may direct questions regarding

the contents of  the chemical toxicity and carcinogenicity tables on

the HEAST  (e.g.,  chemicals  not covered, chemicals  with pending

[RfD]s) to  EPA's Superfund Health Risk Technical Support Center

(TSC) in Cincinnati, OH at (513)  569-7300.

Questions from other users must be submitted to the TSC  in writing

and must contain the following  information;

     -  Superfund  site  name,  site location and twelve-digit
        site number;

     -  Name  and phone number  of the site Remedial Project
        Manager  (RPM) or Regional Risk  Assessor/Toxicologist

     —  Detailed description  of the  risk assessment related
        question.

                                -6-

-------
     Please send requests via mail or FAX to:

     Superfund Health Risk Technical Support Center
     US EPA
     26 W. ML King Dr.
     Environmental Criteria and Assessment Office
     MS 116
     Cincinnati,  OH  45268
     FAX#:   (513) 569-7159

     RCRA Chemicals

     Questions about RCRA chemicals may be addressed by calling the

Health Assessment Section  of the Office of  Solid  Waste at (202)

260-4761.

     Radionuclide Carcinogenicity

     Questions concerning radionuclide carcinogenicity should first

be  addressed  by  contacting the  appropriate Regional  Radiation

Program Manager.  A  listing of these managers and several contacts

in the Office  of Radiation  Programs  can be found in  the User's

Guide - Radionuclide  Carcinogenicity  on  pages  46-48  of the March

1992 HEAST Annual Update.



REFERENCES

     Most cited Agency references (e.g.,  HEAs,  HEEPs, HEEDs),  are

(or  will  soon  be)   available  through  the  National  Technical

Information Service  (NTIS), 5285 Port Royal Road, Springfield, VA

22161 (703/487-4650  or 800/336-4700).  Carcinogen Assessment Group

(CAG) Profiles  cited in Table  3  are available through the  RCRA

docket (202/260-9327).
                               -7-

-------
ORDERING INFORMATION

     Limited copies of the HEAST  are  available for EPA Superfund

staff, State Superfund programs and other Federal agencies working

on Superfund sites,  and EPA contractors working for the EPA Super-

fund program.   Users  in  these groups can  call Syracuse Research

Corporation  (703) 931-7721 to  be  put  on  the mailing list.  (This

number-has been  changed  since  the March  1992 HEAST Annual Update

was published.)

     EPA's Office of  Solid Waste  (OSW) requests  that their users

(i.e., OSW staff, contractors,  State solid waste programs)  call the

Health Assessment Section  (202) 260-4761 to obtain copies of the

HEAST.  Regional OSW staff are  reminded that copies are sent to all

EPA Regional libraries.

     Users of the HEAST  in EPA's  Office  of Air and Radiation and

State air programs should call  Rick Mattick of EPA's Office of Air

Quality Planning and  Standards at (919)  541-3990.

     All other users  must purchase the document from:

        National Technical Information Service (NTIS)
        5285 Port Royal Road
        Springfield,  VA  22161
        (703) 487-4630

     For   ordering  information,  call   the  NTIS  Subscriptions

Department at (703)487-4630.  NTIS normally ships  4th class United

States  mail.   Therefore,  users  may  wish  to consult  with NTIS

concerning  the use of an  overnight  delivery  service.   The NTIS

order  number is  PB92-921100A.
                               -8-

-------
           WHAT'S NEW IN THE JULY 1992 SUPPLEMENT NO.l



     The changes indicated in the July 1992 Supplement No.  1 to the

March 1992 HEAST Annual Update reflect changes in IRIS through June

1, 1992.   It is also current  with RfD/RfC and  CRAVE Work Group

activities through this same date.  Cross-references between tables

may refer the user to the March 1992 HEAST Annual Update for that

information.
A.  CHEMICAL  SPECIFIC CHANGES ON HEAST TABLE  1:   SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

ANTHRACENE
No change  in  the tables.   Reference to the  1992  Drinking Water
Criteria Document (for PAHs) was added.

BERYLLIUM
No change  in  the tables.   Reference to the  1991  Drinking Water
Criteria Document was added.

BROMOMETHANE
Indicator  added to  show  that  the  chronic  inhalation RfC  is
available on IRIS.   The chronic inhalation RfC  on IRIS was adopted
as the subchronic inhalation [RfC].

CAPTAN
The chronic inhalation [RfC] is considered not verifiable  (5/27/92)
by the RfD/RfC work group.

CHLORO-1.3-BUTADIENE
The chronic inhalation [RfC] was added and reflects  the value under
review by the RfD/RfC Work Group.  The subchronic inhalation [RfC]
was derived from the chronic inhalation [RfC].

CRESOL. O-
Indicator added to show that the chronic inhalation RfC  status of
"Not Verifiable" is available on IRIS.

CRESOL. M-
Indicator added to show that the chronic inhalation RfC  status of
"Not Verifiable" is available on IRIS.

CRESOL. P-
Oral chronic and subchronic [RfD]s were added from the 1991 HEED.
Indicator added to show that the chronic inhalation RfC  status of
"Not Verifiable" is available on IRIS.

                               -9-

-------
CYANIDE
No change  in the tables.   Reference to the  1991  Drinking Water
Criteria Document was added.

1.2-DICHLOROETHYLENE (MIXED ISOMERS1
The chronic oral [RfD] was added from the 1991 HEED.  The chronic
oral [RfD] was adopted as the subchronic oral [RfD].

DIETHYLENE GLYCOL MONOBUTYL ETHER
The chronic inhalation [RfC] was added and reflects  the value under
review by the RfD/RfC Work Group.  The subchronic inhalation [RfC]
was derived from the chronic inhalation [RfC].

DINITROTOLUENE
Indicator added to show that the chronic oral RfD  is available on
IRIS.  The chronic oral RfD on IRIS was adopted as the subchronic
oral [RfD].

ENDOSULFAN
The oral subchronic  [RfD] was added from the  1991 HEED.

EPICHLOROHYDRIN
The chronic oral [RfD] was added and states that it was withdrawn
from IRIS  on 4/1/92.   Indicator  added to show  that  the chronic
inhalation RfC is available on IRIS.

FLUORENE
No change  in the tables.   Reference to the  1992  Drinking Water
Criteria Document (for PAHs) was added.

HEXACHLOROCYCLOHEXANE. GAMMA-
The chronic inhalation RfC is considered not  verifiable  (5/27/92)
by the RfD/RfC Work  Group.

METHOXYCHLOR
Indicator added  to  show that the "Not  Verifiable" status of the
chronic inhalation RfC was added to IRIS.

MONOCHLORAMINE
The  chronic oral  [RfD]  was added  from the  1992  Drinking Water
Criteria  Document.    The  chronic oral  [RfD]  was  adopted as the
subchronic oral  [RfD].

PYRENE
No  change in the tables.   Reference to the  1992  Drinking Water
Criteria Document  (for  PAHs) was added.

STYRENE
The chronic inhalation [RfC] was added and reflects the value under
review by the RfD/RfC Work Group.  The  subchronic inhalation  [RfC]
was derived  from the chronic inhalation [RfC].
                               -10-

-------
TRICHLOROBENZENE. 1.2.4-
Indicator added to show that the chronic oral RfD is available on
IRIS.

TRICHLORO-1.2.2-TRIFLUOROETHANE. 1.1.2-
The  subchronic and  chronic inhalation  [RfC]s  were  adjusted to
reflect one significant digit.

VANADIUM SULFATE
The chemical name and CASRN on the Reference Tables were changed to
be consistent with the entry on HEAST Table 1.


B.   CHEMICAL SPECIFIC  CHANGES ON HEAST TABLE 2:   SUBCHRONIC AND
CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)

CHLORO-1.3-BUTADIENE
Chronic and subchronic  inhalation [RfC]s that reflect values under
review by the RfD/RfC Work Group  were added to Table 1  and removed
from Table 2.
C.  CHEMICAL SPECIFIC CHANGES ON HEAST TABLE 3:  CARCINOGENICITY

ACROLEIN
Carcinogen assessment was reviewed by the  CRAVE Work Group.  CRAVE
1992 reference was added.

BENZOTAIPYRENE
Indicators added to show that the oral slope factor and oral unit
risk are available on IRIS.

BROMOCHLOROMETHANE
Carcinogen assessment was reviewed by the  CRAVE Work Group.  CRAVE
1992 reference was added.

BROMOETHENE
The CASRN was corrected to read 593-60-2.

DIMETHYLHYDRAZINE. 1.2-
The CASRN was corrected to read 540-73-8.

ETHYLNITROSOUREA
Carcinogenicity values were added from the 1988  cancer RQ document.

METHYLNITROSOUREA
[EPA  Group]  classification  reflects the  value  currently under
review by  the  CRAVE Work  Group.   The CRAVE Work Group  (4/1/92)
states there is no acceptable quantitation for methylnitrosourea.
Reference to the 1988  cancer RQ document, which is cited as support
for the B2 cancer classification by CRAVE, was added.
                               -11-

-------
TETRACHLOROTOLUENE.  P-aaa-
Target  was  changed to  lung;  critical  effect was  changed  to
adenocarcinoma.

TETRACHLORVINPHOS
The CASRN on the Reference Tables was changed to be consistent with
the entry on HEAST Table 3.


D.   CHEMICAL SPECIFIC CHANGES  ON HEAST TABLE  4A:   RADIONUCLIDE
CARCINOGENICITY — SLOPE FACTORS  (In Units of Picocuries)

THORIUM (901. ISOTOPE Th-232+
The CASRN was corrected to read 7440-29-1.
E.   CHEMICAL SPECIFIC CHANGES  ON HEAST TABLE  4B:   RADIONUCLIDE
CARCINOGENICITY — SLOPE FACTORS  (In Units of Becquerels)

THORIUM (90). ISOTOPE Th-232+
The CASRN was corrected to read 7440-29-1.
                               -12-

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------
    £      i
           <      >-

    >•      co      £
    3      OS      UJ

o  '      g      s

9         £      Z
it         as      uj



OC         S    ||


X         I    zu,




Q         i    l§


§         S    fc§

^          •    Ul CO
           Out    u

_         <    uTo


Z         >    SB
O              £-

CC         uj    i—».

I «-»      5    >-
™" ^_      Of    CD Ul


m H      Is*
5™ —      o    an ee
^ t\      -i    < O
7Z. \J      x    a. u.
(/I —      u    ui
*** ^m           of x
 .  -    I- U
rr.fr"     u    •  u
UJ ^t     •-•    PO

5S ^t     uj    «— uj

* O     8    6^
UJ        5    g£
I— Z     <->    -i o
•"^ TS     a:    z
Q ^     «t    -    co a:

  i ^      CO
***      —» ~> n   co z uj
        _" eo


        6i
        EC.

        O


        X

        o

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------An error occurred while trying to OCR this image.

-------