United States Environmental Protection Agency OSWER (5204-G) ORO (RD-689) 540R92600 OERR 9200.6-303 (92-3) NTIS NO. PB92921102 November 1992 Superfund <&EPA Health Effects Assessment Summary Tables Supplement No. 2 to the March 1992 Annual Update ------- OHEA ECAO-CIN-821 November 1992 HEALTH EFFECTS ASSESSMENT SUMMARY TABLES FY-1992 Supplement No. 2 Office of Research and Development Office of Emergency and Remedial Response U.S. Environmental Protection Agency Washington, DC 20460 ------- DISCLAIMER This report has been prepared by the U.S. Environmental Protection Agency. The information contained herein has been taken from final documents prepared by the Office of Health and Environ- mental Assessment for the Office of Solid Waste and Emergency Response and the Office of Water, Washington, DC and the Office of Air Quality Planning and Standards, Research Triangle Park, NC. These documents were reviewed in accordance with Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. 11 ------- TABLE OF CONTENTS Page INTRODUCTION 1 WHAT'S NEW IN THE NOVEMBER 1992 SUPPLEMENT NO. 2 9 HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) 1-1 HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) 2-1 HEAST TABLE 3: CARCINOGENICITY 3-1 HEAST TABLE 4A: RADIONUCLIDE CARCINOGENICITY - SLOPE FACTORS (IN PICOCURIES) 4A-1 HEAST TABLE 4B: RADIONUCLIDE CARCINOGENICITY - SLOPE FACTORS (IN BECQUERELS) 4B-1 REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) Rl-1 REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) R2-1 REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY R3-1 111 ------- INTRODUCTION This document is the November 1992 Supplement No. 2 for the March 1992 Annual Update of the Health Effects Assessment Summary Tables (HEAST) prepared by EPA's Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for use at both Superfund and RCRA sites. It updates the information in the March 1992 HEAST Annual Update and in the July 1992 Supplement No. 1 for the March 1992 HEAST Annual Update and should be checked whenever those documents are consult- ed. This supplement was not produced to stand alone and does not contain the User's Guides or Appendix that are available in the Annual Update. Thus, the user must reference the March 1992 HEAST Annual Update for this information. The HEAST is a comprehensive listing consisting almost entirely of PROVISIONAL RISK ASSESSMENT INFORMATION relative to oral and inhalation routes for chemicals of interest to Superfund, the Resource Conservation and Recovery Act (RCRA), and the EPA in general. These entries in the HEAST are limited to chemicals that have undergone review and have the concurrence of individual Agency Program Offices, and each is supported by an Agency reference. This risk assessment information has not, however, had enough review to be recognized as high quality, Agency-wide consensus information. The Integrated Risk Information System (IRIS) is the Agency's official repository of Agency-wide consensus chronic human health risk information. IRIS evaluations are conducted by the Agency's _ 1 . ------- Work Group Review process, i.e., they have been examined by either the Reference Dose/Reference Concentration (RfD/RfC) Work Group or the Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. These Agency Work Groups conduct a process that leads to internal Agency scientific unanimous consensus regarding risk assessment information on a chemical. This information is recorded on IRIS, is considered to be "Work Group Verified", and does not appear on the HEAST. Thus, provisional risk assessment information on the HEAST is subject to possible review and revision by these Agency Work Groups. There are two exceptions to the above discussion. The HEAST also contains information on chemicals that are a part of the National Ambient Air Quality Standards (NAAQS) or the Drinking Water Criteria Document (DWCD) series. In each of these cases, the chemicals are subject to extensive scientific peer review processes of extremely high quality. CHEMICAL STATUS DEFINITIONS Chemicals reviewed by the Agency Work Groups are classified according to their status as either "verified", "not verifiable", or "under review". The toxicity values (other than NAAQS or DWCD values) listed on the HEAST are considered to be "provisional". The Agency has no official definitions for these terms, but the HEAST user may interpret them as follows: Provisional: A toxicity value or a cancer value is "provisional" if the value has had some form of Agency review, but it does not appear on the IRIS system. These values are generated in several ways. Often they are determined in the course of developing an Agency document -2- ------- on a chemical or on a class of chemicals. Some have been generated through the Work Group process, but have not yet been input to the IRIS system. At the time each value was derived, all available information on the chemical was evaluated, the value was calculated using the most current methodology, and a consensus was reached on the value by Agency scientists in a program office or ORD. These "provisional" values are found on the HEAST. They do not appear on IRIS. Verified: A toxicity value or a cancer value is "Work Group Verified" if all available information on the value has been examined by an Agency Work Group, the value has been calculated using current Work Group methodology, and a unanimous consensus has been reached on the value by the Work Group. These values have been, or shortly will be added to IRIS. Some "verified" numbers may appear on the HEAST for a short time until they are loaded onto IRIS. During the interim, they are treated as "provisional" values. Not verifiable: A toxicity value is "not verifiable" if an Agency Work Group has considered all available data on a chemical and has unanimously determined that data are inadequate to generate a value that would be suitable for inclusion on IRIS. No toxicity value is calculated. No toxicity values are available for IRIS or the HEAST. This "not verifiable" status, however, has been, or shortly will be noted on IRIS, and is often found on the HEAST, with a pointer to the IRIS system. Under Review: A toxicity value is "under review" if an Agency Work Group is in the process of considering all available data on a chemical. No conclusions have been drawn thus far by the Work Group. Toxicity values that have been withdrawn from IRIS by a Work Group will have this status. This status may be indicated on IRIS or on the HEAST. During this time, toxicity values "under review" may appear on the HEAST and are to be considered "provisional". In all cases, the status of a chemical may change as new data become available, and the assessment is revisited. -3- ------- CAUTION It is imperative for each user of the HEAST to recognize that the values listed in the toxicity tables and the cancer table are generally considered to be PROVISIONAL RISK ASSESSMENT INFORMATION. The user is referred to IRIS for "Work Group Verified" values. It is also important to remember that the numbers in these tables alone tell very little about the adverse effects of a chemical or the quality of evidence on which risk assessment information is based. Original assessment documents must be consulted by users of the HEAST in order to fully appreciate the strengths and limita- tions of a specific data base. Original source documents will allow for the most complete characterization of potential toxicity associated with the range of exposure pathways generally evaluated at Superfund and RCRA sites. The Reference Tables point the user to these sources. CONTRIBUTORS Chemicals commonly found at RCRA sites as identified by the Office of Solid Waste's (OSW) Technical Assessment Branch are included in the HEAST. The Office of Radiation Programs has provided data on radionuclide carcinogenicity for Tables 4A and 4B of the HEAST. The Office of Air Quality Planning and Standards (OAQPS) has provided information on chemicals for which Air Quality Criteria Documents and National Ambient Air Quality Standards have been developed. The Office of Water (OW) has provided information on chemicals for which Drinking Water Criteria Documents have been developed. -4- ------- CHEMICALS LISTED Most of the chemicals included on the toxicity tables and carcinogenicity table are those for which at least one of the following EPA documents has been written: Health Effects Assess- ment Document (HEA), Health and Environmental Effects Profile (HEEP), Health and Environmental Effects Document (HEED), Health Assessment Document (HAD), Air Quality Criteria Document (AQCD), Drinking Water Criteria Document (DWCD). A description of each is provided in Appendix A, Section I of the March 1992 HEAST Annual Update. In a few cases, the values are supported by other written material, such as Work Group meeting notes or Carcinogen Assessment Group (CAG) Profiles. Radionuclides included are those believed to be most commonly encountered at Superfund sites. The names of criteria pollutants that are regulated as National Ambient Air Quality Standards (NAAQS) under the Clean Air Act are listed in the main body of the HEAST, but the actual criteria are included as Section V of Appendix A: Technical Information of the March 1992 HEAST Annual Update. The NAAQS were not included in the tables in order to distinguish them from the provisional reference concentration ([RfC]) values. The NAAQS and [RfCJs represent different levels of review and different methods of calculation and thus, must be interpreted and used differently. HIERARCHY OF SOURCES It is recognized that at any point in time there may be multiple old and new Agency documents or data bases that present different values on a specific chemical. For chemicals other than -5- ------- those represented by the NAAQS or DWCDs, the following hierarchy of sources is recommended in evaluating chemical toxicity for Superfund sites: 1. The Agency's Integrated Risk Information System (IRIS) and cited references. Changes are made in this data base on a monthly basis, but there may be data gaps. Call IRIS USER SUPPORT at 513/569-7254 for further information. 2. The Health Effects Assessment Summary Tables (HEAST) Annual Update and Supplements and cited references. 3. Consultation with the Superfund Health Risk Tech- nical Support Center (TSC) at (513)569-7300. 4. Do not consult either the toxicity tables (Appendix A) in the Superfund Public Health Evaluation Manual (SPHEM, U.S. EPA, 1986) or the September 1988 Public Health Risk Evaluation Data Base (PHRED) as these sources are likely to contain numerous values that have since become out-of-date. QUESTIONS Chemical Toxicity and Carcinogenicity Regional EPA Superfund Staff may direct questions regarding the contents of the chemical toxicity and carcinogenicity tables on the HEAST (e.g., chemicals not covered, chemicals with pending [RfD]s) to EPA's Superfund Health Risk Technical Support Center (TSC) in Cincinnati, OH at (513) 569-7300. Questions from other users must be submitted to the TSC in writing and must contain the following information: - Superfund site name, site location and twelve-digit site number; — Name and phone number of the site Remedial Project Manager (RPM) or Regional Risk Assessor/Toxicologist - Detailed description of the risk assessment related question. -6- ------- Please send requests via mail or FAX to: Superfund Health Risk Technical Support Center US EPA 26 W. ML King Dr. Environmental Criteria and Assessment Office MS 117 Cincinnati, OH 45268 FAX#: (513) 569-7159 RCRA Chemicals Questions about RCRA chemicals may be addressed by calling the Health Assessment Section of the Office of Solid Waste at (202) 260-4761. Radionuclide Carcinoaenicity Questions concerning radionuclide carcinogenicity should first be addressed by contacting the appropriate Regional Radiation Program Manager. A listing of these managers and several contacts in the Office of Radiation Programs can be found in the User's Guide - Radionuclide Carcinogenicity on pages 46-48 of the March 1992 HEAST Annual Update. REFERENCES Most cited Agency references (e.g., HEAs, HEEPs, HEEDs), are (or will soon be) available through the National Technical Information Service (NTIS), 5285 Port Royal Road, Springfield, VA 22161 (703/487-4650 or 800/336-4700). Carcinogen Assessment Group (CAG) Profiles cited in Table 3 are available through the RCRA docket (202/260-9327). -7- ------- ORDERING INFORMATION Limited copies of the HEAST are available for EPA Superfund staff, State Superfund programs and other Federal agencies working on Superfund sites, and EPA contractors working for the EPA Super- fund program. Users in these groups can call Syracuse Research Corporation (202) 479-0881 to be put on the mailing list. (This number has been changed since the March 1992 HEAST Annual Update and the July 1992 Supplement No. 1 were published.) EPA's Office of Solid Waste (OSW) requests that their users (i.e., OSW staff, contractors, State solid waste programs) call the Health Assessment Section (202) 260-4761 to obtain copies of the HEAST. Regional OSW staff are reminded that copies are sent to all EPA Regional libraries. Users of the HEAST in EPA's Office of Air and Radiation and State air programs should call Rick Mattick of EPA's Office of Air Quality Planning and Standards at (919) 541-3990. All other users must purchase the document from: National Technical Information Service (NTIS) 5285 Port Royal Road Springfield, VA 22161 (703) 487-4630 For ordering information, call the NTIS Subscriptions Department at (703)487-4630. NTIS normally ships 4th class United States mail. Therefore, users may wish to consult with NTIS concerning the use of an overnight delivery service. The NTIS order number is PB92-921100 . -8- ------- WHAT'S NEW IN THE NOVEMBER 1992 SUPPLEMENT NO. 2 The changes indicated in the November 1992 Supplement No. 2 to the March 1992 HEAST Annual Update reflect changes in IRIS through November 1, 1992. It is also current with RfD/RfC and CRAVE Work Group activities through September 1, 1992. Cross-references between tables may refer the user to the March 1992 HEAST Annual Update for that information. A. CHEMICAL SPECIFIC CHANGES ON HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) ACETOPHENONE [RfC] values were removed from HEAST Table 2. A statement was added to Table 1 to indicate that the [RfC] is considered not verifiable (6/25/92) by the RfD/RfC Work Group. ALACHLOR No change in the table. Reference to the 1992 HEED was added. BIS(2-ETHYLHEXYL)PHTHALATE No change in the table. Reference to 1991 DWCD was added. CHLOROBENZILATE No change in the table. Reference to the 1991 HEED was added. CYANAZINE The chronic oral RfD was added and a statement indicates that it was withdrawn from IRIS (7/1/92). DIBUTYL PHTHALATE No change in the table. Reference to the 1991 DWCD was added. DICHLOROBENZENE.1.3- A statement was added to indicate that the [RfD] is considered not verifiable (6/23/92) by the RfD/RfC Work Group. DICHLOROBENZENE.1.4- The chronic inhalation [RfC] value was added and reflects the value under review by the RfD/RfC Work Group. The chronic inhalation [RfC] was adopted as the subchronic inhalation [RfC]. DICHLOROETHYLENE.1.2- (Mixed Isomers) The chronic oral [RfD] and the subchronic oral [RfD] were added from the 1991 HEED. -9- ------- PIETHYL PHTHALATE No change in the table. Reference to the 1991 DWCD was added. ETHYLENE THIOUREA A statement was added to indicate that the [RfC] is considered not verifiable (8/12/92) by the RfD/RfC Work Group. HEXACHLOROBENZENE No change in the table. Reference to the 1991 DWCD was added. HEXACHLOROCYCLOPENTADIENE No change in the table. Reference to the 1991 DWCD was added. HYDROGEN SULFIDE No change in the table. Reference to the 1990 HEED was added. MERPHOS A statement was added to indicate that the chronic inhalation RfC is considered not verifiable (6/25/92) by the RfD/RfC Work Group, and an indicator was added to show that this statement has been added to IRIS. MERPHOS OXIDE A statement was added to indicate that the chronic inhalation RfC is considered not verifiable (6/25/92) by the RfD/RfC Work Group, and an indicator was added to show that this statement has been added to IRIS. METHYL ETHYL KETONE [RfC] values were removed from HEAST Table 2. An indicator was added to Table 1 to show that the chronic inhalation RfC is available on IRIS. The chronic inhalation RfC on IRIS is adopted as the subchronic inhalation [RfC]. METHYL PARATHION The subchronic oral [RfD] was changed to reflect the value in the 1991 HEED. MIREX The chronic oral [RfD] , newly added to IRIS is adopted as the subchronic oral [RfD]. MOLYBDENUM An indicator was added to show that the chronic oral RfD has been added to IRIS. NAPHTHALENE The quantitative risk assessment values were removed pending resolution of the RfD/RfC Work Group's position. Contact the Superfund Health Risk Technical Support Center for more informa- tion. (See page 6.) -10- ------- NICKEL No change in the table. Reference to 1991 DW Quantification of Toxicologic Effects document was added. NITROANILINE. 2- Subchronic and chronic oral [RfD] values were removed, and a statement was added to indicate that the chronic [RfD] is consid- ered not verifiable by the RfD/RfC Work Group. PHTHALIC ANHYDRIDE The subchronic and chronic inhalation [RfC] values were added from the 1992 HEED. The chronic inhalation [RfC] was adopted as the subchronic inhalation [RfC]. STRONTIUM. STABLE An indicator was added to show that the chronic oral [RfD] is available on IRIS. The chronic oral [RfD] was adopted as the subchronic oral [RfD]. STYRENE An indicator was added to show that the chronic inhalation RfC was added to IRIS. The subchronic inhalation [RfC] was added to the HEAST. TOLUENE An indicator was added to show that the chronic inhalation RfC has been added to IRIS. The chronic oral RfC was adopted as the subchronic oral [RfC]. TRINITROPHENYLMETHYLNITRAMINE An error was corrected to indicate that the [RfD] is based on a LOAEL. ZINC (METALLIC) An indicator was added to show that the chronic oral RfD was added to IRIS. The chronic oral RfD was adopted as the subchronic oral [RfD]. B. CHEMICAL SPECIFIC CHANGES ON HEAST TABLE 2: ALTERNATE MELTHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) ACETOPHENONE [RfC] values were removed from HEAST Table 2. A statement was added to Table 1 to indicate that the [RfC] is considered not verifiable (6/25/92) by the RfD/RfC Work Group. METHYL ETHYL KETONE [RfC] values were removed from HEAST Table 2. An indicator was added to Table 1 to show that the chronic inhalation RfC is available on IRIS. The chronic inhalation RfC on IRIS is adopted as the subchronic inhalation [RfC]. -11- ------- C. CHEMICAL SPECIFIC CHANGES ON HEAST TABLE 3: CARCINOGENICITY ALACHLOR No change in the table. Reference to the 1992 HEED was added. BIS(2-ETHYLHEXYL)PHTHALATE No change in the table. Reference to the 1991 DWCD was added. BUTYL BENZYL PHTHALATE, N- No change in the table. Reference to the 1991 DWCD was added. CHLOROBENZILATE The [EPA Group] classification and oral and inhalation [slope factor] and [unit risk] values were added from the 1991 HEED. CREOSOTE. COAL-TAR No change in the table. Reference to the 1991 HEED was added. TRICHLOROPROPANE.1.2.3- [EPA Group] classification was added to reflect the classification under review by the CRAVE Work Group. D. CHEMICAL SPECIFIC CHANGES ON HEAST TABLE 4A: RADIONUCLIDE CARCINOGENICITY — SLOPE FACTORS (In Units of Picocuries) INDIUM (49). In-114 The CASRN was corrected to read 13981-55-0. RHODIUM (45) Rh-106 The CASRN was corrected to read 14234-34-5. SILVER (47) Acf-111 The CASRN was corrected to read 157690-04-0. E. CHEMICAL SPECIFIC CHANGES ON HEAST TABLE 4B: RADIONUCLIDE CARCINOGENICITY — SLOPE FACTORS (In Units of Becquerels) INDIUM (49). In-114 The CASRN was corrected to read 13981-55-0. RHODIUM (45) Rh-106 The CASRN was corrected to read 14234-34-5. SILVER (47) Aa-111 The CASRN was corrected to read 157690-04-0. -12- -------An error occurred while trying to OCR this image. -------An error occurred while trying to OCR this image. -------An error occurred while trying to OCR this image. -------An error occurred while trying to OCR this image. -------An error occurred while trying to OCR this image. -------An error occurred while trying to OCR this image. -------An error occurred while trying to OCR this image. ------- o X o I- o z o cc I o Q <> o t z o o z OC LU I O o o 5? COO UJ Of HI U. 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