560784001
OTS INFORMATION ARCHITECTURE
NOTEBOOK
Prepared by:
Henry Lau (Project Manager)
toren Hall
Geri Nowak
Doug Sellers
The matrices included in-this document were prepared by;
Tracor Jitco, Inc.
EPA Contract 68-01-6651
Project Officer: Doug Sellers
Technical Monitor: Geri Nowak
August, 1983
U S Environmental Protection Agency
GLNPO Li
77 West Jacteon
Chicago, II
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The OTS Information Architecture Notebook was prepared to
identify sources of information available to the OTS staff. •
Users of this document may not be aware of where to obtain these
services. MSD maintains two facilities to guide people in the
acquisition of information.
o Non-CBI Information - For assistance in obtaining
literature searches, ready reference, library services,
article acquisition, or translations, people should
contact:
Chemical Information Center (CIC)
Elain Suriano
Room 447 East Tower
Phone 382-3524
o CBI Information - Confidential Business Information
including TDIS, CICIS, arid PMtf material, is included in
the responsibilities of the-
CBI Information Center
Delores Evans
Room 227 East Tower
Phone: 382-7694
If you are not sure whether your request is for CBI or Non-
CBI information, then contract the CIC at the number above.
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I. INTRODUCTION
The purpose of the OTS TSCA Information Architecture Notebook
is to document and analyze OTS scientific and technical infor-
mation requirements for the successful implementation of the Toxic
Substances Control Act (TSCA). Under TSCA, OTS is required to
assess the potential risks and possible benefits of commercial
chemicals not covered under other Federal authorizations. The
investigation of chemical risks and benefits and the development
of regulatory or non-regulatory decisions constantly require the
effective gathering and utilization of pertinent information for
in-depth review and analysis of the effects of the chemical
substances on human health and the environment.
While TSCA provides a mechanism for OTS to collect certain
specific data from industry by rulemaking or to develop data by
conducting testing of chemicals, OTS needs supporting scientific
and technical information from a wide variety of existing data
sources. The supporting data are often avialable in the open
literature, in Government owned or commercially available
computerized data banks and data bases, as well as in manual or
unpublished sources.
This Notebook represents an attempt to assess OTS information
requirements and to identify the major information sources in
which pertinent data are accessible. The ultimate objective is to
identify major information gaps, based on identified requirements
and system coverage, and to recommend a cost-effective mechanism
to obtain or to develop such information. Since both information
requirements and system coverage are likely to change with the
passage of time, the Notebook must be used as a working document
and will be updated periodically.
The Notebook is organized into ten sections, as outlined
under the Table of Contents. Section II of the Notebook presents
a summary of the major functions of OTS (e.g. Health Effects
Analysis, Economic Analysis, etc.) and the major information
resources needed in support of these functions. Section III
describes the three major processes of OTS (i.e. New Chemicals
Review, Existing Chemicals Review, Chemical Testing). In Section
IV of the Notebook, the major data categories and sub-categories
and their definitions are presented. Section V presents a Matrix
matching a set of resource attributes, i.e., search and system
attributes, against the major computerized information resources
containing pertinent information in support of OTS functions and
processes. This section also includes a listing of definitions
for the resources attributes to facilitate understanding of the
matrix.
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In Section VI of the Notebook, there is a presentation of the
OTS analytical capabilities for estimating physical chemical
properties and predicting environmental fate and exposure of
chemical substances. Two matrices are also included, depicting
how the different classes of models and tools are used to support
the various OTS functions and processes. Section VII presents a
series of matrices, matching data categories and data sub-
categories against the major information resources identified in
this Notebook. In Section VIII, matrices matching data sub-
categories against OTS functions are presented. Section IX is a
discussion of the relationship between OTS processes and data
categories and sub-categories. Finally, Section X summarizes and
analyzes the major findings, and discusses major information
gaps.
The matrices developed for this Notebook are intended to
highlight information requirements for the OTS functions/
processes and indicate whether such requirements are being
satisfied by currently available information resources. By
including resource attributes in the matrices, an attempt was made
to depict the quality as well as the accessibility of the
available data. As a result, this should provide the readers with
a better picture of information availabilities and major infor-
mation gaps, and of the qualitative and quantitative aspects of
the information available.
It is hoped that the TSCA Information Architecture Notebook
will be a useful document for OTS. Specifically, the Notebook
should be used as follows:
1. It should provide top OTS managers with a better
understanding about how and what information is being
used to support the OTS functions and processes. It
should also provide sufficient knowledge in determining
priorities and resource commitments for developing or
obtaining data where information gaps are shown, and for
analyzing and determining priorities for data base
development.
2. For the OTS scientific & technical staff, the Notebook
should be a handy reference describing the availabilities
and accessibilities of different types of data from a
variety of sources. Furthermore, the resource attributes
will provide a better understanding of the usefulness and
limitations of the information resources.
For information managers and information specialists,
this should be used as a working document that highlights
OTS information requirements and resources. By
identifying and understanding the requirments for
information and the availabilities of resources, better
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information support services can be provided.
Furthermorer efforts can be taken to develop information
for those areas where gaps are identified and to improve
the efficiency and cost-effectiveness of information
retrieval. This Notebook also provides a continuing
mechanism for communication between the service units
(i.e. MSB) and the user community. Such a dialogue will
lead to a better understanding of user requirements.
4. For system development managers and specialists, the
information strategy should be used to determine needs
and priorities for developing new OTS data bases.
Information needs and data base needs could be
significantly different. In determining needs for data
base development, other factors besides information needs
must be considered. These factors include frequency of
use, cost for system development, and need for
computerized retrieval and data manipulations, etc.
This Notebook is a working document. As information require-
ments and resource capabilities change, the Notebook will be
updated periodically.
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II. OTS FUNCTIONS & INFORMATION RESOURCES
This section describes the major OTS functions under TSCA and
their relationship with the major information resources. For
purposes of this Notebook, seven OTS functions are identified
below:
o Chemical Analysis
o Control Technology Analysis
o Economic Analysis
o Health Effects Analysis
o Environmental Effects Analysis
o Exposure Analysis
o Regulatory Options Analysis
No attempts are made to either associate these functions with OTS
organizational units or to establish any sequential relationship
of the functions.
Risk assessment, a function routinely performed by OTS, is
not included here. From an organization standpoint, risk
assessment integrates the hazard evaluations of the other
functions except regulatory options analysis. Therefore, risk
assessment utilizes the information gathered in support of the
other functions and additional information requirements are
minimal.
To a large extent, regulatory options analysis is similar to
risk assessment in terms of additional information requirements.
Like risk assessment, regulatory options analysis integrates the
evaluative results of the other functions. However, it also needs
information regarding other federal regulations, statutes and
standards. This additional information does not come directly
from the evaluative results of the other functions. For this
reason, regulatory options analysis is included here as a
function.
For each of the aforementioned functions, there is a
descriptive statement about that function. This statement
describes the various steps that are involved in a function.
Following each functional statement, there is a listing of the
major steps, i.e., sub-functions for that function, and the major
information resources that are frequently used to support the sub-
functions. No attempt is made here to associate an information
resource with a sub-function, since such a relationship may
sometimes be misleading.
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Chemical Analysis
Functional Statement
Chemical analysis mainly provides broad technical support in
the area of chemistry for both regulatory and non-regulatory
decision making under the Toxic Substances Control Act. This
analysis includes such areas as: validation of chemical identity;
evaluation of chemical reactions during manufacturing, processing,
and use; identification of impurities, by-products, solvents, and
catalysts; estimation of physical and chemical properties relevant
to manufacturing, processing and use; identification of chemical
constraints on manufacturing, processing, and use conditions;
identification of functional groups or structural features
responsible for chemical reactivity; development of chemical data
for TDIS; and, other aspects of chemical data that may be of
interest to further reviewers. This analysis also identifies
substructures of molecules that are important for identification
of use analogues; classifies substances by use and reactivity;
and, identifies structural and use analogues based on knowledge of
chemical technology and the physical/chemical properties of
molecules. Chemical analysis is used to support all of the other
functions listed below; products of chemical analysis include
initial and detailed assessments of premanufacture notices
(PMN's), analyses to support section 5(h)(4) exemptions and
follow-up activities, section 6 regulatory analyses, and analysis
to support any other regulatory or non-regulatory decision making.
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Chemical Analysis
Major Sub-functions
o Verify generic name
o Ensure description matches:
chemical name,
CAS Registry Number,
molecular formula,
molecular weight,
chemical structure,
synonymns.
o Define physical-chemical properties of chemicals
o Identify structural analogs
o Identify by-products/impurities (i.e., catalysts,
solvents) used in the manufacture of the chemical
o Develop a literature search strategy
o Prepare detailed in-depth use analysis based on economic
and market analysis
o From known properties of chemicals, identify potential
new uses of the chemical
Information Resources
1. Computerized Data Bases (Non-bibliographic)
O CAS ONLINE
o Chemical Abstracts Service (Contract)
O CHEMLINE (MEDLARS)
O CHEMDEX (SDC)
O CHEMLAB (CIS)
O CHEMNAME (DIALOG)
o CHEMSEARCH (DIALOG)
o CHEMSIS (DIALOG)
o CHEMZERO (DIALOG)
O CTCP (CIS)
o DARC (Questel)
o SANSS (CIS)
o TSCA Inventory (CISIS)
o TDIS
o UVCB
2. Computerized Models
O CHEMEST (VAX)
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3. Manual Data Bases
o ICB Card File on Carcinogens
4. Other Sources
o Chemical Dictionaries/Handbooks
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Control Technology Analysis
Functional Statement
Control technology analysis provides support for studies and
analyses of exposure to new chemical and technological alternat-
ives for reducing human and environmental exposure including
personal protective devices and other industrial hygiene measures,
process changes, and effluent controls. It provides a review and
evaluation of production technology and alternative technologies,
and estimates the effects on release and worker exposue resulting
from use of alternative control measures. This function performs
control effectiveness analysis for specific projects according to
the goals, scope, technical approach, and resource requirements
planned for the project.
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Control Technology Analysis
Major Sub-functions
o Determine methods of manufacture, processing or use, and
related worker activities,
o Determine potential for and quantities of environmental
release during manufacture,
o Determine scenarios for worker activities and possible
levels of exposure,
o Describe workplace, engineering exposure controls,
personal protective equipment commonly employed in
industrial processing,
o Describe environmental release controls (i.e., waste
control process) commonly used.
Information Resources
1. Computerized Data Bases (Bibliographic)
O BHRA FLUID OCCUPATIONAL HAZARD (DIALOG)
O CA SEARCH (DIALOG)
O CHEMICAL INDUSTRY NOTES (DIALOG)
O COMPENDEX (DIALOG)
O DOE ENERGY (DIALOG)
O ELECTRIC POWER (DIALOG)
O EIS INDUSTRIAL PLANTS (DIALOG)
O ENVIROLINE (DIALOG)
O INSPEC (DIALOG)
O ISMEC (DIALOG)
O MEDLINE (MEDLARS)
O METADEX (DIALOG)
O NIOSHTIC (DIALOG)
O NTIS (DIALOG)
o PAPERCHEM (DIALOG)
o POLLUTION ABSTRACTS (DIALOG)
O PTS F&S INDEXES (DIALOG)
O PTS PROMPT (DIALOG)
O RAPRA (DIALOG)
o SCISEARCH (DIALOG)
O SURFACE COATINGS (DIALOG)
o TEXTILE TECHNOLOGY DIGEST (DIALOG)
o TOXICOLOGY DATA BANK (MEDLARS)
O TOXLINE (MEDLARS)
O WORLD TEXTILES (DIALOG)
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2. Computerized Data Bases (Non-bibliographic)
o Industry File
o Inventory
o TDIS
3. Other Sources
o Chemical Manufacturers National Inspection Summary Report
(OSHA)
o Document Information Directory System (NIOSH) SRI
o Process Economic Profiles (SRI)
o Chemical Economic Handbook (SRI)
o Handbooks
o Kirk Othmer Encyclopedia
o National Occupational Hazard Survey (NIOSH)
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Economic Analysis
Functional Statement
The main objective of economic analysis is the determination
of potential economic costs and socioeconomic benefits of any
regulatory and non-regulatory control actions on chemical sub-
stances for purposes of the Toxic Substances Control Act. This
function involves analyses of the chemical market, industry
trends, price, price trends, chemical uses, use trends, potential
uses for new chemicals, chemical substitutes and their uses,
etc. It provides economic policy studies as required by TSCA;
provides economic and market studies of chemical compounds;
estimates the economic and socioeconomic impacts of actions taken
under section 4, 5, 6 and 8 of TSCA to gather information on,
require testing of, and to control the manufacture, import,
processing, use and distribution of chemical substances; prepares
Regulatory Impact Analysis, Regulatory Flexibility Analysis and
other economic analyses as required by statute or executive order;
develops scenarios of incentive programs as alternatives to
regulatory options and performs cost-benefit and cost-effective-
ness analyses of alternative regulatory options.
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Economic Analysis
Major Sub-functions
o Determine present and potential uses for chemical,
o Describe historic market patterns,
o Identify manufacturers, location of plants, and
production volumes, prepare manufacturers profile,
o Identify import/export patterns, U.S. and international
market conditions and trends,
o Identify market growth pattern,
o Evaluate economic feasibility of potential substitute
chemicals,
o Evaluate economic impact of substitute chemicals,
o Determine potential substitutes for end product(s) the
chemical is used to manufacture,
o Analyze effect of TSCA rulings on market, or report
burden of cost and economic impact of testing.
Information Resources
1. Computerized Data Bases; (Non-bibliographic)
O CHEMICAL INDUSTRY NOTES (DIALOG)
o CICIS
O CLAIMS/CLASS (DIALOG)
O CLAIMS/PAT (DIALOG)
o Dun & Bradstreet
o DISCLOSURE (DIALOG)
O EIS INDUSTRIAL PLANTS (DIALOG)
o FIND/SVP REPORTS & STUDIES INDEX (DIALOG)
O FOREIGN TRADERS INDEX (DIALOG)
O HARFAX (DIALOG)
o Inventory (CAS)
o MILLION DOLLAR DIRECTORY (DIALOG)
O PAPERCHEM (DIALOG)
O PREDICASTS (DIALOG)
o PTS INDEXES (DIALOG)
o PTS PROMPT (DIALOG)
o Section 8(a) Level A Data Base
o TRADE & INDUSTRY INDEX (DIALOG)
o Toxic Economic Data Base
o X-Market
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2. Manual Data Bases
o PMN Case History Files
o RIB Use Code Data Base
3. Other Sources
o 1977 Census of Manufacturers
o 1980 Census of Manufacturers
o International Trade Commission Report
o Interagency Testing Committee Reports
o Kirk-Othmer Encyclopedia
o Personal Contacts with Industry
o Chemical Economics Handbook (SRI)
o Directory of Chemical Producers (SRI)
o Specialty Chemicals (SRI)
o Process Economics Program (SRI)
o Reference & Textbooks
o Trade Journals
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Health Effects Analysis
Functional Statement
Health effects analysis focuses on assessing the nature and
biological significance of the hazards that chemicals may pose to
human health. This function reviews, validates, and evaluates
test data submitted by industry, along with other relevant re-
search results, and determines chemical toxicity or other harmful
effects in accordance with agency policy. This function identi-
fies, evaluates, and applies new methods and techniques for
epidemiological and laboratory testing in support of OTS programs,
Specific areas of concern include acute, subchronic and chronic
toxicity, onocogenicity, mutagenicity, teratogenicity, neuro-
toxicity, reproductive effects, and other health end points.
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Health Effects Analysis
Major Sub-functions
o Relate chemical structure to potential health effects
(i.e., acute and chronic toxicity/ oncogenicity,
teratogenicity, etc.)
o Substantiate health effects and list uncertainties of
prediction
o Determine adequacy of testing procedures for chemicals
for risk assessment; including evaluation and application
of new test methods
o Screen for potential health effects
Information Resources
1. Computerized Data Bases; (Bibliographic)
o BIOSIA (DIALOG)
O CA ABSTRACTS (DIALOG)
O CANCERLINE (MEDLARS)
O EMIC (ORNL)
O ETIC (ORNL)
O EXCERPTA MEDICA (DIALOG)
o LIFE SCIENCES (DIALOG)
O MEDLINE (MEDLARS)
O NIOSHTIC
o NTIS (DIALOG)
O RTECS (MEDLARS)
O SCI SEARCH (DIALOG)
O TOXICOLOGY DATA BANK (MEDLARS)
O TOXLINE (MEDLARS)
2. Computerized Data Bases (Non-bibliographic):
o DARC (Questel)
o DERMAL ABSORPTION (SPHERE)
O GENE-TOX (SPHERE)
O SANSS (CIS)
O TERA-TOX (SPHERE)
o TDIS
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3. Manual Data Bases
o Chemicals Identified in Human Biological Media
o ITC Profiles
o ITC Reviews
o OPP Registration Data
o Phthalate Clearing House
o Section 8(d) Studies
o TRDB Documents
4. Computerized Models
o ARTHUR (VAX)
O CHEMLAB (VAX)
o Dose Response and Low-Dose Extrapolation Models
o SAS (VAX)
5. Tracking Systems
O CECATS
Section 8(e) Notices
Pre-Chip Hazard Information Profile
Chip Documents
FYI Submissions
6. Other Sources
o Contract Reports
o Industry Studies
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Environmental Effects Analysis
Functional Statement
Environmental effects analysis focuses on assessing the
hazards which specific chemicals may pose to the environment.
This function reviews and evaluates test data submitted by
industry, along with other relevant research results. It
estimates the acute potential and chronic effects that chemicals
may have on aquatic and terrestrial organisms and ecological
systems. This function includes identification of natural
populations at risk and the effects on individual ecological
components, and abiotic environmental systems such as the
atmosphere. It identifies and evaluates new laboratory and field
methods that can be used to more reliably and accurately predict
potential environmental effects.
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Environmental Effects Analysis
Major Sub-functions
o Determine acute and chronic environmental toxicity and
bioconcentration potential of chemicals based on test and
research results, or predict on basis of structure and
knowledge of similar chemicals.
o Define affected ecological components, and natural and
agricultural resources, and populations at risk.
o Develop methods for integrated, interdisciplinary
environmental effect assessment procedures.
o Evaluate methods for field and laboratory studies of
interest to TSCA.
o Screen for potential ecological effects.
Information Resources
1. Computerized Data Bases (Bibliographic)
o AGRICOLA (DIALOG)
o APTIC (DIALOG)
O AQUATIC SCIENCE & FISHERIES (DIALOG)
O AQUALINE (DIALOG)
O ENVIROLINE (DIALOG)
O ENVIRONMENTAL BIBLIOGRAPHY (DIALOG)
O EXCEPTA MEDICA (DIALOG)
O LIFE SCIENCES (DIALOG)
O NTIS (DIALOG)
O OCEANIC ABSTRACTS (DIALOG)
O POLLUTION ABSTRACTS (DIALOG)
O TOXLINE (MEDLARS)
2. Computerized Data Bases (Non-bibliographic)
O ACQUIRE (SPHERE)
o AQUATOX (SPHERE)
O CICIS
o DENVER WILDLIFE RESEARCH CENTER (SPHERE)
o EPA Database & Environmental Model Index (Information
Clearinghouse)
O FISH REPRODUCTIVE (CHIB)
O IEO/GAGE (GEMS)
O ISHOW (SPHERE)
o Needs Survey Data Base (VAX)
o 1977 Census of Manufacturers (GEMS)
o OAQPS Human Activity Patterns (GEMS)
o PEST
o PHYTODOX (HERD)
o RTECS (CIS)
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o SANSS (CIS)
o STAR (GEMS)
O STORET
O SYMN
O TERATOX
o TDIS (Exposure File)
O UVCB
o Wholesale Trade Data (GEMS)
Computerized Models
o CLOGP (VAX)
Manual Data Bases
o ITC Profiles
o ITC Reviews
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Exposure Analysis
Functional Statement
Exposure analysis uses laboratory and field monitoring data,
as well as data from predictive models to generate, as quantita-
tively as possible, assessments of the levels and durations of
environmental, occupational and consumer exposures to chemical
substances. The data used include factors such as chemical
transport and transformation, persistence, as well as data on
physical or chemical factors which may affect exposure levels and
duration. This function provides OTS with estimates of chemical
quantities released to the environment subsequent to treatment and
of the exposures of the population and environmental biota. This
function identifies the ranges of exposure and the exposure to
specific populations or subpopulations. This function also
provides OTS with new procedures to identify potentially exposed
populations or subpopulations, and for conducting exposure
assessments; identifies or develops new techniques for chemical
fate and exposure modeling and physiochemical property estimation;
and examines production release and workplace exposure based on
outputs of the control technology analysis.
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Exposure Analysis
Major Sub-functions
o Substance identification and analysis
o Estimate physical/chemical properties
o Screen chemicals for potential human exposure or nature
and extent of exposure
o Determine materials balances
o Characterize releases after treatment
o Conduct fate analyses/fate modeling
o Identify and characterize human and nonhuman receptor
populations
o Estimate exposures
o Conduct integrated exposure assessments
o Perform control options exposure analysis
o Develop models, test and validate them
o Acquire data for models
o Implement models, data and data analysis programs
o Develop exposure methodologies
o Develop and compile data for exposure assessments
o Develop physical/chemical property and environmental fate
test methods
o Design monitoring studies
o Collect and analyze chemical monitoring data
Information Sources
1. Computerized Data Bases (Non-bibligraphic)
o CHEMFATE
o CICIS
o cLogP (VAX)
o Federal Reporting Data System (FRDS)
o Gauging Station File ("Hydrologically Linked Data System"
— HLDS)
o Geoecology (GEMS)
o Hazardous & Trace Substances Emissions Systems (AEROS)
o Hazardous Waste Data Management System
O IEO/GAGE (GEMS)
o Industrial Facilities Discharge File (4 WDMS)
o National Emissions Data System (AEROS)
o National Occupational Hazard Survey (OTS)
o Needs Survey Data Base (VAX)
o 1977 Census of Manufacturers (GEMS)
o OAQPS Human Activity Patterns (GEMS)
o OHM-TADS (CIS)
o OSHA (DIPS)
o Reach File (HLDS)
O STAR (GEMS)
o Source Test Data System (AEROS)
o Storage & Retrieval of Aerometric Data (AEROS)
o STORET
o Water Supply Data Base (HLDS)
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o Water Quality Monitoring Station File (HLDS)
o Wholesale Trade Data (GEMS)
2. Computerized Models
o ATM (GEMS)
O CHEMEST (GEMS)
O ENPART (GEMS)
O EXAMS (GEMS)
O CLOGP (VAX)
O PTMAX (GEMS)
o SESOIL (GEMS)
3. Other Sources
o NPDES Permits
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Regulatory Options Available
Functional Statement
Regulatory options analysis evaluates alternative remedial
control measures under TSCA, other federal statutes, and non-
regulatory approaches to achieving control of chemical risk. This
function enables OTS to keep abreast of regulatory and non-
regulatory chemical control programs in all sectors of industry.
Specifically, this function is responsible for the identification
and analysis of regulatory and non-regulatory remedial options for
reducing unreasonable risk of injury to health and the environment
from new and existing chemicals under Sections 4,5,6,7,8 and 21 of
TSCA. This function prepares development plans for general or
specific regulatory and non-regulatory projects to prohibit,
limit, or control the manner or method of manufacture, processing,
distribution, use, or disposal of new and existing chemical
substances, and for needed testing of new or existing chemicals.
It provides policy options analyses in support of unreasonable
risk determinations in coordination with the chemical analysis,
control technology, chemical economics, and risk assessment
functions, coordinates with the chemical economics function on the
economic analysis and technological impacts of control programs.
It also provides regulatory support for individual PMN's, TME's
and exemption notices, and drafts 5(e) orders for chemicals which
may cause unreasonable adverse effects. Finally, this function
ensures that regulatory and non- regulatory analyses are
accomplished within current and accepted practice and are in
consonance with OTS and EPA policies including Executive Order
12291, and the Regulatory Flexibility Act.
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Regulatory Options Analysis
Major Sub-functions
o Evaluate alternative remedial control measures under TSCA
and other federal statutes.
o Prepare development for needed testing of new and
existing chemicals.
o Develop plans for regulatory and non-regulatory projects
to prohibit, limit or control the manufacture, method of
manufacture, processing, distribution, or use of new and
existing chemicals.
o Analyze policy options to support unreasonable risk
determinations in coordination with program findings.
o Provides policy option analysis support for PMN's, TME's
exemption notices, and 5(c) orders.
o Ensure accomplishment of above functions within accepted
practice in consonance with OTS and EPA policies and the
Regulatory Flexibility Act.
Information Resources
Computerized Data Bases (Bibliographic)
o CHEMLAW (DIALOG)
o CRGS (DIALOG)
o FEDREG (ORBIT)
O FRSS (CIS)
Other Sources
o Federal Register
o Legislative History
o U.S. Codes
o PMN Case History Files
o PMS
o TDIS
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III. OTS PROCESSES &.INFORMATION RESOURCES
The Office of Toxic Substances is organized around three
major programs or processes. These are:
o New Chemicals Review
o Existing Chemicals Review
o Chemical Testing
In order to implement a process, which is mandated by a specific
section or sub-section of TSCA, various functions and sub-
functions (as discussed in Section II of this Notebook) must be
performed in support of that process.
This section discusses the three major processes in
detail. In each of these processes, a descriptive statement and
a flow diagram about that process are presented. For each
process, the major milestones are identified in the corresponding
flow diagram. In Section IX of this Notebook, the major interim
products from each milestone and the final product for a process
are identified. For each of these products, the pertinent
information requirements are discussed.
Following the functional statements and the flow diagrams
for the three OTS processes is a table listing the major
information resources that are specifically designed or used in
support of a process. A brief description about each of these
systems and its capabilities are also included. For more
detailed information about these information resources, please
refer to the OTS Directory of Information Resources or the OTS
Data Directory.
It must be pointed out that the information resources
described in this section of the Notebook are different from the
bibliographic or non-bibliographic scientific and technical data
bases discussed under Section II or Section V. Since it is
believed that these bibliographic and non-bibliographic data
bases are used to support the various OTS functions which in turn
support the processes, they are therefore not included in this
section. (This will be discussed in detail in Section IX.) The
information resources that are discussed in this section include
indexing or tracking systems or information systems or files that
are specifically designed to provide direct support to the three
processes.
For purposes of this Notebook, the New Chemicals Review
Process includes Premanufacture Notification Review and PMN
follow-up. (Section 5(h)(4) exemption notices review is not
included here, since it is not in implementation. It appears,
however, that this review process may have information require-
ments similar to those for the PMN initial review). The Existing
Chemicals Review Process covers both Chemical Hazard
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Identification and Special Chemical Review. The Chemical Testing
Process covers only Test Rules Development, since there is no
obvious information requirement for the development of Test
Guidelines.
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New Chemicals Review Process
The New Chemicals Review Process has three highly
interrelated components:
o Premanufacture notification review
o Follow-up
o Section 5(h)(4) exemption
Among these three components, only the first two have been in
implementation. Since limited PMN's will still be submitted to
EPA by manufacturers who wish to have their chemicals considered
for 5(h)(4) exemptions, it is believed that information
requirements for processing the exemption notices will closely
resemble those for the initial review stage of a regular PMN
submission. Information requirements for the exemption activity
will be discussed in future updates of this Notebook.
The functional statements for the Premanufacture
Notification Review and the Follow-up components of the New
Chemicals Review Program are presented in the following pages.
Descriptions for the major information, indexing and tracking
systems used, and flow diagrams follow the functional statement.
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III-4
New Chemicals Review Process
I. Premanufacture Notification Review
Functional Statement
The Premanufacture Notification Review Program is
responsible for the receipt, evaluation, and disposition of TSCA
section 5 premanufacture notices, test market exemptions and
5(h)(4) exemption notifications, within the time constraints
imposed by TSCA or by regulation. The program is managed by CCD
while the technical efforts in the program are carried out by
other OTS divisions. The Premanufacture Notification Review
Program: (1) receives, interprets and validates data submitted
with each PMN; (2) gathers and reviews additional data; (3)
prepares risk assessments; (4) communicates with the submitting
company as necessary for clarification or for additional data;
(5) determines either dropping or referring chemicals for more
detailed risk and benefit/cost analysis, after preliminary risk
screening; (6) recommends appropriate measures, informal or
regulatory, to control and reduce risks; and (7) makes
recommendations after appropriate analysis and review to follow
up on new chemical uses.
The Premanufacture Notification Review Program: (1) is
responsible for identifying and implementing needed action to
ensure compliance with TSCA intent including actions for
limitations or injunctions under TSCA section 5(e) or 5(f), in
coordination with the Office of the General Counsel, and arranges
for hearings, as necessary; (2) identifies new chemicals that
require control, and recommends control alternatives; (3)
negotiates for appropriate controls; (4) identifies new chemicals
which may be controlled or otherwise affected by other EPA
programs, or other Federal regulatory Agencies. The
Premanufacture Review Program manages the development,
evaluation, and revision of reporting procedures and forms for
new chemical premanufacture review, and oversees public hearings
on rules, procedures, and reporting forms associated with
premanufacture review. (For more detailed information about the
PMN process, see Description of PMN Review Process prepared by
the OTS Chemical Control Division).
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III-5
New Chemicals Review Process
II. Follow-Up Process
Functional Statement
The Follow-Up Process manages the development of specific
rules under TSCA Section 5, negotiated control actions and other
actions that may be necessary to achieve the reduction of
unreasonable risk for chemicals with new uses. Recommends and
implements OTS policy on TSCA section 5 exemptions, early exits,
and significant new use rules (SNURS). Considers requests for
exemptions, e.g., site-limited rule, low volume rule, polymer
rule, and specific manufacturing exemptions. Manages the
development and promulgation of all follow-up actions on
chemicals not on the TSCA Initial Inventory (i.e., rules under
5(a)(2); rules for significant new uses of chemicals; development
of section 8(a) follow-up rules). Manages the review and
revision of general program rules as appropriate to program
implementation, coordinating resources with the Premanufacture
Notification Review Program and other OTS and EPA offices.
Performs liaison with EPA headquarters and regional enforcement
activities in establishing and maintaining an effective program
of monitoring compliance with TSCA section 5 rules.
More specifically, this process evaluates chemicals using
the following procedures:
o Follow-up focus meeting
o Toxicity validation
o Initial new use exposure analysis
o Technical integration reports
Determines whether regulatory action under section 5(a)(2)
or 8(a) is warranted. OTS Division Directors review regulatory
recommendations for each candidate and decide if regulatory
analysis is required. If regulatory action is appropriate,
regulatory development is initiatied. SNURS, 8(d) rules are
drafted, sent for Agency review, and proposed as final rules.
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III-6
Existing Chemical Review Program
Functional Statement
The Existing Chemical Review process develops, oversees, and
manages projects to define specific existing chemical problems
warranting detailed evaluation and possible risk reduction action
by OTS. This process performs the initial evaluation of data and
petitions submitted to EPA under TSCA Section 4, 8(a), 8(c),
9(d), 8(e) and 21, and similar data submitted by other routes to
determine whether the data indicate a significant risk to human
health and environment. It determines whether the submitted
data, in conjunction with other available information, pose a
definite potential "problem" in terms of identifying a specific
chemical, activity, exposed population, and adverse effect which
warrant referral to the appropriate program for further TSCA
action. Where current information is strongly indicative of a
potential problem but inadequate to fully define the problem, the
Existing Chemical Review process identifies appropriate
mechanisms to obtain additional information needed to reach a
disposition such as encouraging voluntary data submission, using
TSCA Section 8 authorities, using EPA chemical testing resources,
or referring chemicals to the Interagency Testing Committee
through the EPA member. It oversees the evaluation of regulatory
and non-regulatory control alternatives and makes recommendations
for the most appropriate mechanisms to reduce risk. Existing
Chemical Review plans and manages programs to encourage use of
specific exposure reduction practices by the chemical industry
through informational programs and development of Risk Management
Advisories. Where rulemaking under Section 5 (Significant New
Use Rule) or Section 6 is necessary, this process refers to other
OTS processes as appropriate.
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III-7
Chemical Testing Process
Functional Statement
The Chemical Testing Process is responsible for the
development of criteria and procedures for evaluating whether
chemical substances or categories of chemical substances should
be subject to test rules under section 4 of TSCA. While many
technical efforts in support of the program are carried out by
other OTS divisions, the Program reviews and makes appropriate
recommendations on negotiated or regulatory actions on the
chemical substances, mixtures, and categories recommended for
testing consideration by the TSCA Interagency Testing Committee
and others. The program, in coordination with the above-
mentioned technical representatives, is also responsible for:
(1) developing test guidelines and protocols for testing and
developing Good Laboratory Practice requirements; (2) assessing
the availability of adequate testing facilities and personnel;
(3) preparing test rules or decisions not to test as required
under section 4 and holding public hearings on such rules after
proposal; and (4) developing rules and procedures for granting
exemptions from testing and for reimbursement under section 4(c);
(5) reviewing and responding to requests for exemptions; and
(6) negotiating with industry to achieve testing through
negotiation.
-------
III-8
Major Information Resources
Specifically Designed or Frequently
Used in Support of OTS Processes
New Chemicals Review Process
o PMN Analog Card File
o PMN Card File
o PMN Case Files
o PMN Tracking System
o Technical Data Indexing System (TDIS)
o TSCA Master Inventory File
Existing Chemicals Review Process
o Chemical Regulations and Guidelines System (CRGS)
o CHIP Existing Chemicals Tracking System (CECATS)
Chemical Testing Process
o Global Indexing System (For Section 8(d)
submissions)
o ITC Hazard Information Profiles*
o ITC Hazard Information Reviews*
o ITC Tracking System*
o Section 8 (a) Level A Information System
o Test Rules Development Support Documents
Used by the Interagency Testing Committee
-------
III-9
Brief Summaries About the
Information Resources Designed or
Used in Support of OTS Processes
1. Chemical Regulations and Guidelines System (CRGS): An
automated on-line system covering Federal statutes,
promulgated regulations, and Federal guidelines and standards
related to the control of chemical substances. Each chemical
cited in a regulatory document is indexed by chemical name,
CAS Registry Number, and a context in which the substance
appears in the document. Each document is described in terms
of publication date, title, abstract, index terms, and
chemical identifiers.
2. CHIP Existing Chemicals Tracking System (CECATS); An
automated document tracking system for existing chemicals,
including all CHIP and pre-CHIP compounds, and those
substances submitted under section 8(e) of TSCA or on an FYI
basis. CECATS in organized into seven interconnected
files. The user can use the system to document decisions and
types of information included and determine status of the
substance within OTS.
3. Global Indexing System (In Section 8(d) Submissions); A
general indexing system designed to facilitate retrieval of
documents. For 8(d) submissions, the user can search by
chemical identifiers or by submitting company.
4. ITC Hazard Information Profiles: A manual file of brief and
concise summaries of chemical, physical, health and
environmental effects data on a chemical derived from limtied
review of readily available information sources. The
Interagency Testing Committee uses it for supporting TSCA
Section 4 test rules development.
5. ITC Hazard Information Reviews; A manual file containing
detailed information on exposure, chemical/physical
properties, biochemistry, toxicity and environmental effects
for specific chemicals and categories of chemicals selected
for study by the Interagency Testing Committee.
6. ITC Tracking System; An automated system that provides quick
tracking of chemicals studied by the Interagency Testing
Committee and the decisions on each chemicals.
7. PMN Analog Card File; A manual file of chemicals that have
been searched as analogs for PMN chemicals, including, for
each substance, the CAS Registry Number, chemical
nomenclature, and PMN number.
8. PMN Card File; A manual file of PMN and TME chemical names
and structures, filed by both PMN number and chemical
substructures. This file is used to identify previous PMN's
that relate to ongoing reviews.
-------
111-10
9. PMN Tracking System; An automated tracking system with
statistical capability that is used in support of PMN
review. It tracks the status of each PMN or TME submission
from date of submission through notice of commencement of
manufacture. It is used to prepare monthly and weekly
reports to the PMN program.
10. Section 8(a) Level A Information System: An automated system
containing the data collected under the Preliminary
Assessment Information Rule under Section 8(a) of TSCA. This
system provides such information as chemical identity, plant
site location, plant site activities, manufacturer products
and consumer uses of chemical substances designated for
testing by the Interagency Testing Committee. The system
provides a tracking capability to monitor form submissions
under the reporting rule.
11. Technical Data Indexing System (TDIS): An automated system
designed specifically for supporting the PMN review process
by indexing PMN data and thereby providing quick referrals to
historical analyses of chemicals similar to the subject
chemical under review. Chemicals can be searched by name
fragments and special functional codes. This system also
allows for statistical analysis of trends in PMN decision-
making.
12. Test Rules Development Support Documents; A manual file of
review documents prepared to assist in evaluating the health
and/or environmental effects of chemicals nominated for
testing by the Interagency Testing Committee.
13. TSCA Master Inventory File; A collection of automated as
well as manual files maintained by the Chemical Abstracts
Service under contract with OTS. This file contains 60,000
chemicals and represents the most up-to-date file of
substances reported for the Inventory and of substances that
have been introduced into U.S. commerce after completing
Section 5 PMN review. This file is used for supporting the
PMN review process by conclusively determining whether a
substance is on the Inventory.
-------
III-ll
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IV-1
IV. DATA CATEGORIES, SUB-CATEGORIES & DEFINITIONS
This section classifies the currently known OTS user
information requirements into the following nine major data
categories:
o Substance Identification
o Physical Chemical Properties
o Health Effects
o Environmental Effects
o Production/Processing
o Use/Disposal
o Exposure
o Chemical Economics
o Regulations/Controls
Within each of the nine major data categories, sub-categories are
identified. A sub-category is not necessarily a data element; it
may, in some cases, represent a group of data elements.
The classification of data categories and sub-categories is a
complex and difficult task. There is probably no one single
"correct" way of categorizing the types of technical data that OTS
needs in support of the implementation of TSCA. Therefore, some
of the data categories were developed partially based on specific
information requirements for certain OTS functions, e.g., Health
Effects (for Health Effects Analysis), Environmental Effects (for
Environmental Effects Analysis), or Chemical Economics (for
Economic Analysis). However, certain data categories, e.g.,
Physical Chemical Properties, Use, etc. may reflect the
traditional grouping of data elements from an information
management standpoint, and do not necessarily align themselves
with specific OTS functions. Physical Chemical Properties data,
for example, are used in support of such OTS functions as Chemical
Analysis, Exposure Analysis, and Environmental Effects Analysis.
In determining how certain sub-categories should be listed
under a specific data category, two factors were taken into
consideration. First, a sub-category is placed under a data
category which, from a hierarchial standpoint, is the most logical
parent of that sub-category. Therefore, for example, CA Index
Name (a sub-category) is listed under Substance Identification (a
major category). Second, if a sub-category can be logically
placed under more than one major category, that sub-category is
then listed under the more appropriate category. For example,
Method of Manufacture (a sub-category) is listed under Substance
Identification (a major category) instead of Production/Processing
(another major category), since this information is often needed
in establishing the identity of a substance.
-------
IV-2
To facilitate use and understanding of the data categories
and their sub-categories, several data organization techniques are
used. First, a scope note is included for each major data
category, describing the scope or special features of that
category. (A scope note is, nevertheless, not a definition and,
therefore, does not define a category). Second, a definition (in
some cases, a scope note) is developed for each sub-category.
Third, where a sub-category may be logically placed under more
than a single major category, the more appropriate category is
chosen to incorporate that sub-category and its definition. The
same term is repeated under the less appropriate category without
a definition, and a "See" reference is used referring the reader
to the more appropriate category. For example, Method of
Manufacture is listed under Substance Identification with a
definition. The same term is repeated under Production with a
"See Substance Identification" cross reference. Fourth, for
related sub-categories, "See also" references are used. For
example, a "See also Production/Processing" cross reference is
included for Method of Manufacture (under Substance Identification),
alerting the reader that there is a related term, i.e., Production
Technology, listed under Production/Processing. This will allow
the reader to consult the related term if necessary.
In using this section of the Notebook, the following must be
taken into consideration:
1. For each data category, only those sub-categories that
are needed by OTS are included. Therefore, a category may not
include all of the possible sub-categories.
2. Some of the sub-categories represent the types of
information that are not readily available in either the open
literature or existing information resources.
3. The definitions for the sub-categories are not
necessarily the types of definitions that can be found in a text
book or a dictionary. Many of the definitions are scope notes
describing what is covered under a sub-category.
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IV-3
A. SUBSTANCE IDENTIFICATION
Sub-Categories
(Note: The data sub-categories included are those that are needed
in establishing the identity of a chemical substance as defined by
TSCA. Data elements for identifying Class II substances are also
included.)
1. CA Index Name
2. CAS Registry Number
3. Synonym
4. Molecular formula
5. Chemical description/composition
6. Method of Manufacture (See Substance Identification:
Synthetic Reactions and Constraints)
7. Synthetic reactions and constraints (See also Production/
Processing; Production Technology)
8. Structural diagram
9. Method of identification
10. Indices of structure
11. Linked substances
For purposes of this Notebook, this sub-category is not included
in the matrices presented. From an informational standpoint,
this sub-category is included under the other sub-categories of
the Substance Identification category.
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IV-4
A. SUBSTANCE IDENTIFICATION
Definitions
1. CA Index Name; A unique, fully systematic name assigned
by the Chemical Abstracts Service (CAS) in accordance with
a set of rigorous and comprehensive nomenclature rules to
ensure that a single preferred name can be developed for
each chemical substance. The CA Index Name is sometimes
referred to as the CAS Preferred Name. A CA Index Name
may be made up of several parts, each playing a specific
role in describing a chemical substance. The principal
portion is the "heading parent" which describes the most
significant feature(s) of the substance. Additional parts
of the name are appended to the heading parent to describe
substituent groups, derivative information, and
stereochemistry.
2. CAS Registry Number; A number consisting of up to 9
digits is assigned by the Chemical Abstracts Service to
represent only one chemical substance, insofar as that
substance has been elucidated and defined. The CAS
Registry Number is usually separated into 3 portions by
hyphens. The first portion, starting from the left, has
up to 6 digits; the second portion has 2 digits and the
last portion consists of a single check digit which is
used to validate of the entire Registry Number.
3. Synonym; A synonymous chemical name which may be a non-
systematic chemical name, a common name, a trade name, a
class name, a code, or a trivial name. Care must be
exercised in using the synonymous names since they often
do not uniquely describe a chemical substance.
4. Molecular Formula; A systematic summation of the actual
numbers and kinds of atoms present in a molecule of a
chemical substance. For Class II substances and polymers,
the molecular formula often identifies only the kinds of
atoms present, as the number of atoms is unknown or
variable.
5. Chemical Description/Composition; In certain Class II
substances and polymers, where the CAS Index/Preferred
Name may not be sufficiently detailed, a chemical
description is required to identify the substances
completely. The definition may include descriptions of
the synthetic reaction or reaction pathway, the relative
amounts of precursors or reactants, composition, and
certain physical/chemical properties.
6. Method of Manufacture; (See Substance Identification;
Synthetic Reactions and Constraints)
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IV-5
7. Synthetic Reactions and Constraints: A description of the
reactants, the synthetic reaction(s) used, and any
chemical constraints on the reaction(s) that must be taken
into account when the substance of interest is produced.
Typical chemical constraints include the use of high
pressure or heat and the exclusion of oxygen or water
vapor. Synthetic reactions often include the mechanism of
the reaction if this is unusual, or the identification of
side-reactions if these are significant. A complete group
of synthetic reactions and side-reactions should elucidate
the origin of impurities, by-products, and co-products.
(See also Production/Processing; Production Technology.)
8. Structural Diagram^ A 2-dimensional representation of the
bonds and atoms, their connections, and stereochemical
relationships in a molecule of chemical s.ubstance. For
Class II substances, this diagram will be illustrative
only and may be incomplete. In the case of polymers, the
range and average degree of polymerization may be
included.
9. Method of Identification; The analytical technique and/or
protocol used in establishing the identity of a chemical
substance.
10. Indices of Structure; This section includes such things
as codes for functional groups, rings, degree of
complexity, and categories of Class II substances.
11. Linked Substances;
(a) By-products; Chemical substances "produced without
separate commercial intent during manufacture or
processing of another chemical substance(s) or
mixture(s)." FEDERAL REGISTER (42 FR 64575)
Inventory Reporting Regulations (40 CFR 710.2)
(b) Co-products: Chemical substances "produced for a
commercial purpose during the manufacture, processing
use, or disposal of another chemical substance(s) or
mixture(s)." FEDERAL REGISTER (44 FR 2264) Premanu-
facture Notification Requirements and Review Proce-
dures (40 CFR 720.2)
(c) Impurities; Chemical substances "unintentionally
present with another chemical substance." FEDERAL
REGISTER (42 FR 64576) Inventory Reporting Regula-
tions (40 CFR 710.2).
(d) Stabilizers, emulsifiers, catalysts, and other
additives, that are intentionally present. Not
defined here.
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IV-6
B. PHYSICAL/CHEMICAL PROPERTIES
Sub-Ca tegories
(Note: The listing of physical chemical properties covers only
those that are frequently used by OTS for TSCA purposes.)
1. Melting Point
2. Boiling Point
3. Vapor Pressure
4. Partition Coefficient (Log P)
5. Solubility
6. Density
7. Relative Vapor Density
8. Henry's Law Constant
9. Adsorption Coefficient
10. Dissociation Constant (ka or kj-,)
11. Flash Point
12. Flammable Limits
13. Molecular Weight
14. Color
15. Odor
16. Physical State
17. Particle Size
18. Chemical Incompatibility
19. pH
20. Extractability
21. Hydrolysis Rate
22. Viscosity
23. Decomposition Temperature
24. Sublimation Temperature
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IV-7
B. PHYSICAL CHEMICAL PROPERTIES
Definitions
1. Melting Point; The melting point is the temperature at
which a substance changes from the solid to the liquid
state. It indiates at what temperature solid substances
liquify.
2. Boiling Point; The boiling point is the temperature at
which a liquid under standard atmospheric pressure (or
other specified pressure) changes from the liquid to the
gaseous state. It is an indication of the volatility of a
substance. The distillation range in a separation process,
the temperature at which the more volatile liquid of a
mixture forms a vapor, is used for mixtures in the absence
of a boiling point.
3. Vapor Pressure; The vapor pressure of a substance is the
pressure which a vapor, in a closed container and in
equilibrium with its solid or liquid form, exerts on the
enclosing walls. It is a function of the substance and, if
it reaches the prevailing atmospheric pressure, the liquid
boils or sublimes. It provides an indication of the
relative tendency of a substance to volatilize.
4. Partition Coefficient (log P); The n-octanol/water
partition coefficient is the ratio of a substance's
concentration in water-saturated octanol divided by its
concentration in octanol-saturated water at equilibrium.
The n-octanol/water partitioning system provides an
indication of a substance's ability to bioconcentrate in
aquatic and other organisms. The information is frequently
reported as the common logarithm of the partition
coefficient, log P, rather than as the partition
coefficient itself.
5. Solubility; The solubility of a substance in water (or
other solvent) is the weight of the dissolved substance per
volume water of solution in water (or other solvent) when
the solution is at equilibrium with an excess of the
substance, i.e., saturated at a specific temperature. This
definition is limited to homogeneous materials.
6. Density; Density is the mass of a liquid, solid or gas per
unit volume of that substance, i.e., the mass in grams
contained in 1 cubic centimeter of a substance at 20°C and
1 atmosphere pressure.
7. Relative Vapor Density; Relative Vapor Denisty is the ratio
of the weight of a gas to the weight of an equal quantity of
air. Air, the standard, is given the value of 1.
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IV-8
8. Henry's Law Constant; The Henry's Law Constant
quantitatively expresses the effect pressure has on the
solubility of gas. The Law states that the mass of a
slightly soluble gas that dissolves in a definite mass of
liquid at a given temperature is very nearly directly
proportional to the partial pressure of that gas. This
assumes that the gas does not unite chemically with the
solvent.
9. Adsorption Coefficient; This coefficient, e.g., the
Freundlich Adsorption Coefficient, attempts to quantify the
adherence of a substance to a surface. The transport,
degradation and bioavailability of a substance are greatly
affected by its adsorption properties.
10. Dissociation Constant (Ka, Kh): The dissociation constant
(Ka or K^) represents the degree of ionization of BrjzJnsted
acids ana bases in solution. Usually reported as the nega-
tive logarithm (pKa Or pKb) of the dissociation constant.
11. Flash Point; The Flash Point is the temperature at which a
liquid or volatile solid gives off a vapor sufficient to
form an ignitable mixture with the air near the surface of
the liquid or within the test vessel.
12. Flammable Limits; Flammable Limits denote the concen-
tration range, of a vapor or gas in a mixture with air, at
which the flammable or explosive mixture will ignite and
continue burning on its own after ignition.
13. Molecular Weight; A summation of the individual atomic
weights based on the numbers and kinds of atoms present in
a molecule of a chemical substance. For polymers and
certain Class II substances, this may include molecular
weight distributions, ranges, and averages.
14. Color; The aspect of objects (including chemical
substances) that may be described in terms of hue, light-
ness, and saturation. Includes both qualitative (e.g.,
buff-colored) and quantitative (e.g., absorption maximum at
5800 Angstroms) description of color.
15. Odor; A description of the smell of a chemical substance.
16. Physical State; Whether a chemical substance is a gas,
liquid,or solid under ambient or other given conditions.
17. Particle Size; The average diameter of the individual
particles in a particular solid. Often both average
particle size and range of particle size are used.
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IV-9
18. Chemical Incompatibility! The capacity of a chemical
substance for facile reaction with another chemical
substance to produce an undesired product. For example,
isocyanates are chemically incompatible with aqueous
solutions, which hydrolyze the isocyanate groups.
19. pH: A value taken to represent the acidity of alkalinity
of an aqueous solution; it is defined as the logarithm of
the reciprocal of the hydrogen ion concentration of a
solution:
pH = log
t H+ ]
20. Extractability; This includes extractability by water or
other solvents as reported according to various sources
(ASTM, etc. ).
21. Hydrolysis Rate: The rate of reaction of a chemical
substance with water to form a new substance or sub-
stances. Usually not applied to reactions where oxidation
or reduction of water is involved.
22. Viscosity; The internal resistance to flow exhibited by a
fluid. A liquid has a viscosity of one poise of a force of
one dyne per square centimeter causes two parallel liquid
surfaces one square centimeter in area and one centimeter
apart to move past one another at a velocity of one centi-
meter per second. Viscosity in poises divided by the
liquid density at the same temperature gives kinematic
viscosity in stokes.
23. Decomposition Temperature: The temperature at which heat
causes the chemical degradation of a substance into two or
more substances, which may differ from each other and from
• starting materials. The decomposition temperature of a
substance is often of interest if it is below the melting
point of the substance.
24. Sublimation Temperature; The temperature at which the
partial pressure of a vapor in equilibrium with a solid
substance is equal to one atmosphere. At this temperature,
the solid passes directly into the vapor state without
appearing in the intermediate liquid state.
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IV-10
C. HEALTH EFFECTS
Definitions
(Note: The sub-categories listed below represent the different
types of human/animal toxicity data that OTS needs in evaluating
the health effects of chemical substances for purposes of imple-
menting TSCA. Headings in parenthesis are included for easy
understanding of the sub-categories; they should not be used as
sub-categories.)
(General Toxicity)
1. Acute/Subchronic Toxicity
2. Chronic Toxicity
(Local Toxicity)
3. Eye Irritation
4. Skin Irritation
(Specific Toxicity)
5. Mutagenicity
6. Neurotoxicity
7. Oncogenicity
8. Sensitization
9. Reproductive Toxicity
10. Teratogenicity
(ADME)
11. Absorption
12. Distribution
13. Metabolism
14. Excretion
(Epidemiology)
15. Epidemiology
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IV-11
C. HEALTH EFFECTS
Definitions
(Generalized Toxicity)
1. Acute/Subchronic Toxicity; Immediate or short term response
of an organism to a single dose of a chemical substance
through various routes of exposure. Refers to generalized
toxic response with lethality usually being the observed
endpoint. Includes LD5Q/ LC50, LDLo and other quantitative
endpoints.
2. Chronic Toxicity; Response of an organism to repeated, long-
term exposure to a chemical substance. Length of exposure
and time of response varies with the organism. Observed
endpoints may be on sublethal or lethal effects.
(Local Toxicity)
3. Eye Irritation; Reactions produced in the eye after exposure
to a chemical substance. Damage may be assessed by changes
in the cornea, iris, and conjunctiva, in the intraocular
pressure, in capillary permeability, and in other in vivo and
in vitro conditions.
4. Skin Irritation; Local inflammatory response of the skin
observed after exposure to a chemical substance. Exposure
can be a single, repeated, or prolonged contact. Manifes-
tations include erythema, edema, ulceration, necrosis, and
formation of scar tissue. Skin irritation does not involve
the immune mechanism.
(Specific Toxicity)
5. Mutagenicity; Inheritable changes in the linear structure of
DNA caused by exposure to a chemical substance.
6. Neurotoxicity Behavior; Observed effects to the nervous
system caused by exposure to a chemical substance. Includes
effects to neuromuscular transmissions and pathological
changes in nerves, spinal cord, or brain. Behavioral effects
are also included under this category.
7. Oncogenicity: Tumor formation observed in organisms in
response to exposure to a chemical substance. May include
number, type, site, growth rate and ability to metastasize of
tumor.
8. Sensitization; A response of the immune system (an allergic
reaction) of a organism caused by its being exposed to a
chemical substance.
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IV-12
9. Reproductive Toxicity; Observed effects on reproductive
organs or reproductive performance of an organism caused by
exposure to a chemical substances. Includes egg laying,
fertilization, number of offspring, and sexual and asexual
reproduction. Excludes tertogenic effects on offspring (See
Teratogenicity).
10. Teratogenicity: Abnormalities observed in offspring of
females exposed in utero via chemical substance, and changes
in birth weight, developmental delays, or fetal death.
(ADME)
11. Absorption; The uptake of a chemical substance through a
membrane, by an organism. Absorption may be represented
quantitatively sometimes as rate.
12. Distribution; The internal transport and deposition of a
chemical substance in body fluids, tissues, and organs.
Distribution can be reported quantitatively.
13. Metabolism; The physical or chemical alteration of a
chemical substance by an organism.
14. Excretion; Elimination of a chemical substance or its
metabolites by an organism. Excretion can be represented
quantitatively and may include rate.
(Epidemiology)
15. Ep idemiology; Study of the exposure and toxic responses of
human and animal populations to chemical substances. Can
include frequency and geographic distribution.
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D. ENVIRONMENTAL EFFECTS
Sub-Categories
(Note: The sub-categories listed below represent the different
types of data that OTS needs in evaluating the environmental
effects of chemical substances for purposes of implementing
TSCA. Although some of the terminologies used are identical or
similar to those listed under the Health Effects category, they
nevertheless have different meanings and may be defined
differently. Headings in parentheses are included for easy
understanding of the sub-categories; they should not be used as
sub-categories.)
(Aquatic Effects)
1. Acute Toxicity
2. Chronic Toxicity
3. Sublethal Toxicity
4. Bioconcentration/Biomagnification
5. Field Studies
(Terrestrial Effects)
6. Acute Toxicity
7. Chronic Toxicity
8. Behavioral Toxicity
9. Reproductive Toxicity/Teratogenicity
10. Absorption, Distribution, Metabolism, Excretion
11. Field Studies
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IV-14
D. ENVIRONMENTAL EFFECTS
Definitions
(Aquatic Effects; Includes effects of chemical substances on
aquatic vertebrates and invertebrates as well as vascular and non-
vascular aquatic plants.)
1. Acute Toxicity; Immediate, or short term response of an
organism upon exposure to a chemical substance. Refers to
generalized toxic response with lethality usually being the
observed endpoint. Includes LD50, LC5Q, LDLo and other
quantitative endpoints.
2. Chronic Toxicity; Response of an organism to repeated, long-
term exposure to a chemical substance. Length of exposure
and time of response varies with the organism. Observed
endpoints may be based on sublethal or lethal effects.
3. Sublethal Effects; Response of an organism exposed to a
chemical substance that results in effects other than
mortality including: behavioral, reproductive, growth and
physiological effects.
4. Bioconcentration/Biomagnification; The uptake and retention
of a chemical substance in an organism or in organs or
tissues of an organism (bioconcentration). An increase in
the tissue concentration of organisms higher in the food
chain (biomagnification).
5. Field Studies; An experiment in which organisms are exposed
to a chemical substance in a body of water that is located
outside the laboratory and is influenced by natural
conditions.
(Terrestrial Effects; Includes the effects of chemical substances
on terrestrial vertebrates and invertebrates as well as vascular
and non-vascular terrestrial plants.)
6. Acute Toxicity; Immediate, or short term response of an
organism to a single dose of a chemical substance through
various routes of exposure. Refers to generalized toxic
response with lethality usually being the observed
endpoint. Includes LD50/ LC5g, LDLo and other quantitative
endpoints.
7. Chronic Toxicity; Response of an organism to repeated, long-
term exposure to a chemical substance. Length of exposure
and time of response varies with the organism. Observed
endpoints may be based on sublethal or lethal effects.
8. Behavioral Effects; Behavioral manifestations of a
organism's response to a toxic chemical substance. May
include avoidance, effects on motor activity, appetite and
other behavioral characteristics specific to the organism.
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IV-15
9. Reproductive Effects; Observed effects on reproductive
organs or reproductive performance of an organism caused by
exposure to a chemical substance. Includes egg laying,
fertilization, number of offspring, and sexual and asexual
reproduction. (For teratogenicity, see Health Effects.)
10. Absorption, Distribution, Metabolism, Excretion; The uptake,
by an organism, of a chemical substance through a membrane,
may be represented as a rate value. The internal transport
and deposition of a chemical substance in fluids, tissues and
organs. The physical or chemical breakdown of a chemical
substance by an organism, possibly including metabolites.
The elimination of a chemical substance or its metabolites by
an organism.
11. Field Studies; An experiment in which organisms are exposed
to a chemical substance in a natural habitat or in an
artificial habitat that is located outside the laboratory and
operated under natural conditions.
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E. PRODUCTION/PROCESSING
Sub-Categories
(Note: Production and processing are two of the several
important stages in the flow of a chemical substance through the
environment. The other stages are use and disposal which are
covered under a separate category).
Identification)
1. Manufacturer/Importer
2. Processor
3. Plant site (See also Exposure)
4. Method of manufacture (See Substance
5. Production technology
6. Processing technology
7. By-product (See Substance Identification)
8. Co-product (See Substance Identification)
9. Production volume
10. Amount by site
11. Production loss (See also Exposure)
12. Import volume
13. Export volume
14. Production trend
15. Production capacity by site (See Chemical Economics)
16. Sales volume
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IV-17
E. PRODUCTION/PROCESSING
Definitions
1. Manufacturer/Importer; The complete identification, i.e.,
name and address, of a chemical manufacturer or importer.
2. Processor; The complete identification, i.e., name and
address, of a person who processes chemical substance.
3. Plant Site; The name and address of a specific
manufacturing plant site for a chemical substance.
4. Method of Manufacture; (See Substance Identification)
5. Production Technology; The engineering process(es)
employed by industry that yields the chemical substance in
question.
6. Processing Technology; The group of unit operations
utilized for processing a chemical substance.
7. By-product; (See Substance Identification)
8. Co-product; (See Substance Identification)
9. Production Volume; The total amount of a chemical
substance produced in the U.S. in a given year.
10. Amount by Site; The amount of a chemical substance
produced or processed at a specific plant site in a given
year.
11. Production Loss; The estimated amount of a chemical
substance that is lost during normal production process.
(See also Exposure)
12. Import Volume; The amount of a chemical substance
imported into the U.S. in a given year.
13. Export Volume; The amount of a chemical substance
exported from the U.S. in a given year.
14. Production Trend; The trend in production volume for a
10-year(or less) period.
15. Production Capacity by Site; (See Chemical Economics)
16. Sales Volume; Amount actually purchased by customer.
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F. USE/DISPOSAL
Sub-Categories
(Note: A categorizaion of use and disposal information should
include data that are used in supporting estimation of exposure
as well as chemical economic analysis. Use information covers
both contained as well as dispersed uses.)
1. Function
2. Application
3. Additional use description (technical)
4. Additional use description (economic)
5. Mode of application
6. Use trend
7. Use amount
8. User location (See also Exposure and Production/
Processing)
9. Use analog (technical)
10. Use analog (economic)
11. Method of disposal
12. Amount disposed
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IV-19
F. USE/DISPOSAL
Definitions
1. Function; This describes "what, where and how" a
chemical substance does in its prescribed use. This
represents a general breakdown of use information.
2. Application; The end use application of a chemical
substance. This is the manufacturing, service, or
consumer activity in which the major function of a
chemical substance is utilized. Application is therfore
a specific breakdown of a major use type.
3. Additional Use Description (Technical); A detailed
description of use based upon chemical structure,
physical/chemical properties, and reactivity. This
description highlights the technical aspects that make a
particular substance suitable (or not suitable) for a
particular use.
4. Additional Use Description (Economic); A detailed
description of use based upon chemical marketing and
other economic considerations. This description
highlights the economic aspects of use.
5. Mode of Application; This describes how a chemical
substance is applied in use. For example, spraying of
paint.
6. Use Trend; The general trend and pattern for a use.
7. Use Amount; The amount of a chemical substance for a
specific use category.
8. User Location; The name and address of a company which
is a major user of a specific chemical substance. (See
also Exposure; Geographic Distribution/Location
Coordinates of Release and Production/Process ing;
Processor.)
9. Use Analog (Technical); A chemical substance that can
perform the same function or application as another
chemical substance, based on similarities of chemical
structure, physical/chemical properties, and
reactivities.
10. Use Analog (Economic); A chemical substance that can
successfully substitute for another chemical substance in
commerce. This definition also includes analogues for
end use applications. These analogues are developed
based on the price and availability of technical use
analogues.
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IV-20
11. Method of Disposal; The method by which a chemical
substance is discharged into the environment. Examples
of disposal methods include incineration, open-burning,
landfill, etc.
12. Amount Disposed; The amount of a chemical substance
disposed by the various methods of disposal.
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G. EXPOSURE
Sub-Categories
(Note: Exposure covers such areas as release, fate, populations,
monitoring as well as general location. Effects data are not
included here. Headings in parentheses are included for easy
understanding of the sub-categories; they are not intended for use
as sub-categories.)
(Chemical Release and Control)
1. Production Technology (See Production/Processing)
2. Engineering Control Technology
3. Amounts/Rates/Characteristics of Releases
4. Geographic Distribution/Location Coordinates of Releases
5. Release Source Characteristics
6. Product Formulation and Characteristics
7. Function(s)/Application(s)/Mode of Application (See Use/
Disposal)
8. Worker Activities
9. Personal Protective Equipments
(Environmental Fate)
10. Physical/Chemical Properties (See Physical/Chemical Properties)
11. Environmental Characteristics
12. Transport/Tranformation Characteristics and Partitioning
13. Chemical Concentrations in Environmental Media
(Receptor Populations)
14. Geographic Distribution
15. Identity and Characteristics of Subpopulations
16. Behavioral/Demographic Characteristics
17. Non-human Populations
(Monitoring)
18. Source
19. Ambient
20. Personal
21. Tissue
(General Location)
22. Cartographic Data/Geographic Coding Files
(Route of Exposure)
23. Route of Exposure
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IV-22
G. EXPOSURE
Proposed Definitions
(CHEMICAL RELEASE AND CONTROL)
1. Production Technology; (See Production/Processing)
2. Engineering Control Technology; This identifies the
hardware, unit operations or equipment operating practices
which limit the release of the chemical substances to the
workplace or environment and describes any treatment of the
contaminated media at the release or receptor site before it
reaches the receptor. Treatment efficiencies are
determined. Examples include POTW and industrial waste
treatment used, disposal methods, potable water
purification, and air purification systems in indoor
ventilation.
3. Amounts/Rates/Characteristics of Releases; These are
determined for any chemical release to workplace, environ-
ment, or consumer vincinity during the life cycle of the
chemical, i.e., during its manufacture, processing,
distribution, commercial or consumer use, and disposal.
Amount of release indicates quantity. Rate of release
indicates periodicity (e.g., batch ejection from an
industrial outfall, or slow continuous leaching form
disposal site) and exit volume/time. Characteristics of
release include relevant physical/chemical properties of the
waste stream, form of the chemical, mass, concentration,
frequency and duration, etc. For example, a solid, liquid,
gas, or particulate might be dispersed in an aerosol or
smoke.
4. Geographic Distribution/Location Coordinates of Releases;
These are also determined for release points during all
phases of a chemical's life. Latitude/longitude coordinates
of sources are the most useful data. Precise coordinates
are usually only relevant to manufacturing sites, e.g.,
individual outfalls along a river reach. Another type of
example would be the gross number or density of dry cleaning
facilities in a city.
5. Release Source Characteristics; In general, this will
identify the nature ofthe release source, e.g., an open air
refinery, an enclosed plant, a disposal site, a truck or
railroad car spill. This category also includes specific
characteristics such as stack height, number of plant
outfalls, and average capacity of transport vehicles.
6. Product Formulation and Characteristics; This describes
products with regard to the chemical concentration in the
product, the physical form of the product, relevant
dispersion media specific to the product (such as solvents),
and the chemical relationship of the chemical to the product
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IV-23
formulation (e.g., is the chemical bound in the product
matrix?). Also, the performance characteristics of the
product are discussed.
7. Function(s)/Application(s)/Mode of Application; (See Use/
Disposal)
8. Worker Activities; Steps taken by workers in the workplace
which can result in potential exposure.
9. Personal Protective Equipments; Equipments which reduce
worker exposure to chemical substances released in the
workplace.
(ENVIRONMENTAL FATE)
10. Physical/Chemical Properties; (See Physical/Chemical
Properties)
11. Environmental Characteristics; These identify and
characterize the medium that becomes contaminated, such as
air, ground and surface water, or soil. This category would
include meteorological data, such as wind speeds and
rainfall, surface and groundwater characteristics, and soil
types and their physical/chemical characteristics.
12. Transport/Transformation Characteristics and Partitioning;
Partitioning refers to the relative distribution of a
chemical among environmental media. Transport refers to the
potential movement of the chemical from one media
compartment to another. Transport parameters would include
volatilization from surface water and soils and adsorption
to soil and sediments. Transformation refers to a
chemical's change in structure. The major processes that
can effect transformation are photolysis, oxidation,
hydrolysis, biotransfor##well as abiotic media (e.g., air
and water). Bioconcentration (see Environmental Effects) is
relevant to this category with regard to chemical
concentration estimates in biotic media.
(RECEPTOR POPULATIONS)
14. Geographic Distribution; This describes "where" exposure
will occur.Location and density of human populations are
evaluated. In different types of assessments the
distribution of residences in a particular city or county,
or in U.S. urbanized areas in general, would be of interest.
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IV-24
15. Identity and Characteristics of Subpopulations; This
describes "who" will be exposed, whether consumer, worker or
general population. The potentially affected populations
are identified, enumerated, and characterized with para-
meters such as their age, sex, and sensitivity to certain
chemicals or exposure situations.
16. Behavioral/Demographic Characteristics: This describes
"how" or to what extent the population is exposed. Examples
of those data include consumption patterns of consumer
population(s) and commuting patterns of the residential
population(s). With regard to occupational exposure, the
duration and frequency of activity that results in exposure,
and use of protective equipment are relevant items.
17. Non-Human Populations: This category includes the "where,
who,and how"for exposure to non-human populations as
described for human populations above.
(MONITORING)
18. Source; This category includes data on release source and
characteristics measured at point of actual release.
Sources discharging to the air include point, line, and area
sources. Sources discharging to water include point and
non-point sources. Sources can be both fugitive in nature
or from confined equipments.
19. Ambient; Point at which release is in media and can no
longer be controlled.
20. Personal; Personal monitoring refers to the data collected
by a portable sample collector carried by a volunteer.
These data can provide an integrated picture of chemical
exposure in all the microenvironments through which the
volunteer passes.
21. Tissue; Tissue monitoring data include the amount of
chemical substance in particular tissues or organs at a
given time.
(GENERAL LOCATION DATA)
22. Cartographic Data/Geographic Coding Files; Cartographic
data refer to computerized data that are digitized
representations of maps. These are typically used in
displaying other (thematic) data. Examples include county
and state boundary files. Geographic coding files may be in
hard copy or computerized and relate one type of geographic
area coding to another, e.g., census tracts within ZIP code
areas or cities within states.
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IV-25
(ROUTE OF EXPOSURE)
23. Route of Exposure; The mode by which human or the environ-
ment is exposed to a chemical substance. For example, route
of human exposure may be dermal contact or inhalation, and
route of environmental exposure may be air, water or land.
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IV-2 6
* *
H. CHEMICAL ECONOMICS
Sub-Categories
(Note: The data sub-categories include all those that are needed
by OTS in performing economic analysis of chemical substances for
purposes of implementing TSCA. From a data organization stand-
point, many of these sub-categories are more appropriately listed
under other data categories.)
1. Manufacturer (See Production/Processing)
2. Plant site (See Production/Processing)
3. Total annual sales
4. Annual chemical sales
5. Production capacity by site (See also Production/Processing)
6. Price
7. Price trend
8. Function (See Use/Disposal)
9. Application (See Use/Disposal)
10. Use trend (See Use/Disposal)
11. Use amount (See Use/Disposal)
12. Method of manufacture (See Substance Identification)
13. Production technology (See Product ion/Process ing")
14. Sales by end uses
15. Employment by plant site (See also Exposure)
16. Production trend (See Production/Processing)
17. Production volume (See Production/Processing)
18. Production cost
19. Demand elasticity
20. Sales volume (See Product ion/Process ing)
Other sub-categories listed under Production/Processing and/or
Use Disposal may be needed for chemical economics analysis.
Please refer to those two categories.
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H. CHEMICAL ECONOMICS
Definitions
1. Manufacturers; (See Production/Processing)
2. Plant Site; (See Production; See also Exposure; Geographic
Distribution/Location Coordinates of Releases.)
3. Total Annual Sales; The total annual sales of a company in
terms of dollars for all products and services.
4. Annual Chemical Sales; The total annual sales of a company
in terms of dollars for all chemical substances manufactured
by that company.
5. Production Capacity by Site; The production capacity for a
chemical substance within a plant site. (See also
Production/Processing; Amount by Site.)
6. Price; The current sale price of a chemical substance.
7. Price Trend; The 10-year price trend of a chemical
substance.
8. Function; (See Use/Disposal)
9. Application; (See Use/Disposal)
10. Use Trend; (See Use/Disposal)
11. Use Amount; (See Use/Disposal)
12. Method of Manufacture; (See Substance Identification)
13. Production Technology; (See Production/Processing)
14. Sales by End use; The amount of sales per use for a chemical
substance.
15. Employment by Plant Site; The number of employees per plant
site. This information is used to determine the number of
employees that may be adversely affected by an EPA action.
In many cases, the number of people outside a plant site
(e.g., truck drivers) may also be needed. (See also Exposure)
16. Production Trend; (See Production/Processing)
17. Production Volume; (See Production/Processing)
18. Production Cost; The total cost for producing a chemical
substance.
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19. Demand Elasticity; The relationship between price and
demand.
20. Sales Volume; (See Production/Processing)
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V-l
V. INFORMATION RESOURCES ATTRIBUTES MATRIX
This section presents the resources attributes of the major
computerized data banks and data bases that can be used in support
of the OTS functions and processes under TSCA. Manual resources
are included in Section VII of the Notebook since they have few
but significantly different attributes.
There are two types of resources attributes that are used to
describe a computerized information resource, i.e., search
attributes and system attributes. While search attributes pertain
mainly to the searchability and retrieval features of the data,
system attributes describe characteristics of the system including
hardware and software used and access mode. The search and system
attributes of online data bases outline for the user what
features, information, and capabilities are available. This
display will help to make the user aware of the variety of
information resources available, decide which attributes can
facilitate access and select the most appropriate resource(s)
which can solve the information problems.
This section contains three parts. The first part is the
matrix outline, listing resources attributes in a hierarchial
format. Following the hierarchial listing is a matrix matching
search and system attributes against computerized information
resources. In this matrix, the attributes are listed on the
horizontal axis in the same sequence as they appear in the
hierarchial listing. The computerized information resources are
placed on the vertical axis of the matrix and are divided into two
main groups, i.e., bibliographic data bases and non-bibliographic
data banks. Within each of these two groups, the systems are
listed in alphabetical sequence. The major computerized models as
discussed in Section VI are also included in the Matrix. In the
matrix, the information resources are either indexed by a "X"
symbol or by some other alpha or numeric notations. For
explanations on the notations used in the matrix, consult the
attributes definitions in this Section. The last part of this
section is a listing of definitions (or sometimes scope notes) for
the attributes.
For additional information on the information resources, the
readers may consult the OTS Directory of Information Resources or
the OTS Data Dictionary.
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V-2
OTS Information Resources Attributes
MATRIX Outline
I. Search Attributes
I.A. Chemical Searching
I.A.I. Substructure
' I.A.I.a) Connection Table
I.A.l.b) Wiswesser Line Notation (WLN)
I.A.l.c) Key (Screen) Codes
I.A.l.d) Graphics (Searchable)
I.A.2. Chemical Reference Numbers
I.A.2.a) CASRN
I.A.2.b) Other
I.A.3. Name Match
I.A.3.a) Exact
I.A.3.b) Fragment
I.A.3.c) Non-Systematic (Synonym)
I.A.S.d) Systematic
I.B. Retrieval Features
I.B.I. Subject Seaching
I.B.I.a) Free Text
I.B.l.b) Proximity Search
I.B.l.c) Index Terms
I.B.l.d) Thesaurus
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V-3
I.B.2. Numeric/Alphanumeric Availability
I.B.2.a) Data Values
I.B.2.5) Data Values (Rangeable)
I.B.3. Bibliographic Information
I.E.3.a) Author
I.B.S.b) Title (Source Document)
I.B.S.c) Year of Publication
I.B.3.d) Title (Journal, Book)
I.B.3.e) Abstract
I.B.S.f) Language
I.B.3.g) Abbreviated/Coded Citation
I.E.4. Logical Searching
I.E.4.a) Field (Indirect) Search
I.B.4.b) Boolean Logic (Within Field)
I.B.4.C) Boolean Logic (Across Field)
I.C. Resource Characteristics
I.C.I. Display Features
I.C.I.a) Abbreviated
I.C.l.b) User Defined
I.C.l.c) Tables
I.C.l.d) Graphics
I.C.l.e) Offline
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V-4
I.C.2. File Size and Use
I.C.2.a) No. Records
I.C.2.5) No. Chemicals
I.C.2.C) Frequency of Use
I.C.3. Data Base Characteristics
I.C.3.a) Update Cycle
I.C.3.b) Cost
I.C.3.c) Period of Coverage
I.C.4. Search Aids
I.C.4.a) Printed Source
I.C.4.b) Online Help
I.C.5. File/Content Characteristics
I.C.5.a) Unpublished
I.C.S.b) Ongoing research
I.C.S.c) Data Quality
I.C.S.d) International Sources
II. System Attributes
II.A. System Access
II.A.1. Source
II.A.2. Status
II.A.3. Interactive
II.A.4. Telecommunication
II.A.5. Restricted Access
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V-5
II.B. Hardware
II.B.I. Computer Utilized
II.B.2. Computer Owner [1-EPA; 2-Contractor;
3-Developer]
II.C. Software
II.C.I. Program Language [e.g., COBOL, PL/1, BASIC]
II.C.2. DBMS [e.g., System 2000, ADABAS]
II.C.3. Library Program [e.g., EASYTRIEVE,
SAS, MARK IV]
II.C.4. Command Language [e.g., TSO]
II.D. Data Processing Features
II.D.I. Data Entry
II.D.2. Data Editing
II.D.3. Data Manipulation
II.E. System User Aids
II.E.I. System Documentation
II.E.2. Data Dictionary Defined
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V-6
OTS Information Resource Attributes MATRIX
Attribute Definitions
Standard dictionary definitions have been used or attributes have been
described according to their use or as applied to OTS information activities.
The definitions are listed in a hierarchial manner as presented in the matrix
outline:
I. Search Attributes:
I.A. Chemical Searching:
I.A.1. Substructure:
I.A.1.a)
I.A.1.b)
I.A.1.c)
I.A.1.d)
characteristics of the data base
which denote content and accessibility options.
search and retrieval options
available to represent chemical substances or
parts thereof which
a partial chemical structure represented by
atoms and their bonding.
Connection table - a method of representing
chemical structure. Each atom in the
structure is listed together with its attached
atoms and bonds. Search on this type of data
may be transparent to the user; but
essentially does not use codes to indicate the
presence of specific rings or fragments.
WLN - Wiswesser Line Notation, a system of
symbols (alphanumeric characters) designed to
describe molecular structures in detail and
permit computer searches.
Key (Screen) Codes - standard codes (sometimes
called "screen codes") which are used to
retrieve specific substructures or functional
groups. An example would be input of '48' to
retrieve six-membered rings.
Graphics (Searchable) - the full or partial
structure of a chemical can be used to
retrieve data.
G - the structure can be generated for
searching graphically.
K - the structure can be generated for
searching using strings of characters.
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V-7
I.A.2. Reference Numbers:
I.A.2.a)
I.A.2.b)
I.A.3. Name Match:
I.A.3.a)
I.A.3.b)
I.A.3.C)
I.A.3.d)
I.B. Retrieval Features:
I.B.1. Subject Searching:
any number used to uniquely identify a
specific chemical or chemical class
directly or indirectly.
CAS Registry Number - a number assigned by
Chemical Abstracts Services (CAS) as each
substance is registered. Note: a check in
this column indicates that the CAS Registry
Number can be used to search for chemicals,
not just displayed in a record.
Other - any other alphanumeric term used to
identify a chemical, company, standard,
etc. and which refers directly or indirectly
to a chemical or chemical class. Examples
include NIOSH numbers (chemical), Standard
Industrial Codes (company), and DOT label
(standard).
the ability to retrieve a substance based on
nomenclature.
Exact - the name must be entered exactly as
it appears in the database, including word
order and punctuation.
Fragment - substances can be retrieved based
on partial names.
Non-systematic (Synonym) - multiple names
which may be available for a single
substance. Such names may include trivial
names, trade names, production names, or
common names.
Systematic - a chemical name assigned based on
a specific naming scheme indicating the exact
structure of a chemical. The two most widely
used schemes are those designed by CAS and
IUPAC.
denotes the availability of textual and
numeric information and the logical
relationships available to access the
information/data directly or serially.
concepts, topics and descriptions which can
be specified in a search.
-------
V-8
I.B.1.a)
I.B.1.b)
I.B.1.c)
I.B.1.d)
Free Text - the data in the field is not taken
from a controlled list of terms, but words are
indexed as they are added.
Proximity Search - the user may specify that
certain words must appear adjacent to each
other in the text, in the same sentence, in
the same field, etc.
Index Terms - a controlled vocabulary or terms
used to describe the data in each field, which
is available for searching.
Thesaurus - list of controlled vocabulary
terms, usually cross-referenced and often
showing the relationship between terms, which
is available to the user from the computer
while using the search system or in hard copy.
Coded: H = hard copy
L = ONLINE
I.E.2. Numeric/Alpha-
numeric
Availability:
I.B.2.a)
I.B.2.b)
data is available in the record
and can be searched and
retrieved.
Data values - indicates whether the exact
content of a specific field can be used as a
basis for searches. For example, if a
database carries boiling points and compounds
with a boiling point of 10°C can be retrieved,
this attribute will qualify as searchable.
Similarly, if a database carries toxicity data
but compounds with e.g., a specific LD50 that
cannot be retrieved, the numeric data is not
searchable. If this column is checked, it
indicates that at least some of the data
reported is searchable or rangeable.
Data (Rangeable) - data (as described above)
can be searched by expressing a range of
numeric values, rather than a specific
value. For example, toxicities between 10 and
30 mg/kg or production volumes greater than
10,000 Ibs/year. If this column is checked, it
indicates that at least some data is range-
searchable.
-------
V-9
I.B.3. Bibliographic
Information:
I.E.3.a)
I.B.3.b)
I.B.S.c)
I.B.3.d)
I.B.3.e)
I.B.3.f)
I.E.4 Logic Searching:
I.B.4.a)
I.B.4.b)
General information referring the
user to the document from which the data was
extracted (source document).
All bibliographic information columns are
coded as follows:
P - this type of data may be displayed but
cannot be used for searching.
s - this type of data can be used as the
object of a search and/or displayed in
retrieved records.
Author - the author of the source document.
Title - the title of the source document,
including articles in journals.
Year of publication - data on which the
document was published.
Journal - journal in which the source document
appears.
Abstract - summary of the content of a
specific article.
Abbreviated/coded citation - a truncated or
less than full revision of the standard
bibliographic reference, e.g., use of CODEN
instead of journal title.
Operators or aids allowing manipulation of
search terms to provide more specific
comprehensive searches.
Field specific - capability to search selected
specific fields (indirect search or serial
search)
Boolean logic (within fields) - a method of
logic developed by George Boole, an English
mathematician, which uses logical operators -
AND, OR, and NOT - to show relationships
between sets or terms. In this case the sets
or terms must involve the same field of data.
-------
V-1 0
i.e.
I.B.4.C)
Resource
Characteristics:
I.C.1. Display Features:
I.C.1.a)
I.C.1.b)
I.C.1.c)
I.C.1.d)
I.C.2.
I.C.1.e)
File Size:
I.C.2a) No Records:
Boolean logic (between fields) - logical
operators can be used to link separate fields,
such as toxicity and production.
Options for printing retrieved
information and file-specific features
relating to content, coverage, covering and
cost.
Display features allow the user to examine
search results.
Abbreviated format - a portion of the
record is shown, allowing the user to rapidly
scan large files. This is preprogrammed, and
varies in length.
User defined - user can specify which fields
are to be displayed from the full record.
Tables - results can be displayed in a concise
table, defined by the user.
Graphics - capability to display structures,
maps, statistical and other pictorial
representations.
Structure - chemical structures can be
displayed after retrieval. This column is
coded as follows:
T - structure can only be
displayed on the user's
terminal
0 - structure can be displayed on
the user's terminal or in
hard copy offline.
Offline - search results can be printed at
the computer site, rather than on the user's
terminal, and mailed to the user.
Number of total unit records and number of
chemicals included in the file.
A record is a unit of related information in a
database. For example, a record is generally
meant to include all the information stored
for a particular document in a bibliographic
system.
-------
V-1 1
I.C.2.b)
No Chemicals:
I.C.3. Data Base
Characteristics:
I.C.3.a)
Update Cycle:
Number of unique chemicals,
substances, formulations, generic classes,
etc., in a database.
Information on currency, cost,
and coverage.
Frequency of additions to the
records in a database. This column is coded
as follows:
0 - closed file
I.C.3.b) Cost:
1 - daily
2 - weekly
3 - biweekly/semimonthly
4 - monthly
5 - bimonthly
6 - quarterly
7 - semiannually
8 - annually
9 - irregular
Cost per connect hour. This does not include
subscript fees, print cost, or
telecommunication fees.
I.C.3.C) Coverage:
I.C.4. Search Aids:
I.C.4.a.) Printed
Source:
I.C.4.b) Online Help:
I.C.5. File/Content
Characteristics:
I.C.5.a) Unpublished
Data:
I.C.S.b) Ongoing
Research:
Span of coverage.
Curr = only latest information (e.g., last 3
months)
Tutorial help on searching the
file; or description of file contents.
Data base, partial or complete,
is available in hard copy.
Provides options for search and retrieval
relative to a user's status with this
interaction in a system.
Denotes publication type and
quality of the data as described by the data
base producer.
Data which is not in the public
domain, e.g., processing, communications,
private files, etc.
Database contains references to
research which is in progress.
-------
V-1 2
I.C.5.C) Data
Quality:
II.
Indicates whether the data has
been evaluated by the database producer prior
to incorporation, for accuracy, completeness,
and quality. This column is coded as follows:
0 - No evaluation prior to
incorporation (data may be
taken from referred
journals).
1 - Quality indicator available.
2 - Peer evaluated.
I.C.S.d.) International Data is taken from non-U.S.
Sources:
System Attributes:
II.A. System Design
Access:
II.A.1. Source:
II.A.2. Status:
II.A.3. Interactive:
II.A.4. Telecommunications:
sources (may be in addition to U.S.
sources).
Characteristics and features of the hardware
and software.
Communication connections and
availability of the data base to the end user.
Availability of the data base to the end user.
C = commercial
P = private
Denotes the current availability of a data
base.
D = developed
U = under development
A system which allows the user to input
instructions, receive a response, and then
modify or manipulate the results.
The network which provided the link between
the terminal and the host computer. This
column is coded as follows:
1 - international/National access. Via
telecommunications network.
2. - International access, no
telecommunications network.
3. - Local access, i.e., long distance call
outside computer area.
-------
V-1 3
II.A.5. Restricted Access:
II.B. Hardware:
II.B.1 Computer Utilized:
4. - In-house access only, no
telecommunications available.
The system is available to a limited user
community, e.g., contains confidential data,
is available only for "in-house" use, etc.
Denotes manufacturer name, series, level,
model and owner of the equipment.
Denotes specific hardware in which data base
resides.
VAX = VAX 11/780
IBM = IBM
UNI = Univac
II.B.2 Computer Owner:
II.C. Software:
II.C.1. Program Language:
Organization which owns or leases hardware.
1 - EPA
2 - Contractor
3 - developer of data base
Set of instructions (programs) or routines for
handling input into the computer.
Defined set of Characters and rules used for
writing a computer routine e.g., COBOL, PL/1,
BASIC.
II.C.2. DBMS:
Denotes data base management system used e.g.,
System 2000, ADABAS.
II.C.3. Library Program:
II.C.4. Command Language:
II.D. Data Processing
Features:
Denotes use of a canned or standard software
program e.g., EASYTRIEVE, SAS, Mark IV.
Provides direct interface with the central
processing unit & determines data entry and
editing facilities, submission and retrieval
capabilities, and utility and data set
manipulation functions e.g., TSO, ELHILL
Denotes existence of facilities,
and utilizes for handling data by the
end-user.
II.D.1 Data Entry:
II.D.2. Data Editing:
Capability exists to input data.
Capability exists to add, delete, & modify
data.
-------
V-1 4
II.D.3. Data Manipulation: Capability for statistical analysis and
computation.
II.E. System User Aids: Documentation for end user to facilitate
interaction with the system.
II.E.1. System Documentation: User manual available
II.E.2. Data Dictionary Description of data element and
Defined: its use within the organization that developed
the data base.
-------
VI-1
VI. OTS ANALYTICAL CAPABILITIES
In addition to drawing upon existing information in the form
of data bases and manual resources, OTS functions and processes
often require the development of new information. Much of this
information is the result of applying a variety of analytical
capabilities to existing data in order to draw conclusions useful
in risk assessment. This section discusses these analytical
capabilities which include computer models and estimation
techniques and describes how they are used in support of OTS
functions and processes.
OTS scientists utilize: (1) general statistical packages
such as the Statistical Analysis System (SAS); (2) more
specialized statistical analysis capabilities to perform complex
univariate and multivariate analyses (e.g., cluster analyses
using ARTHUR); (3) programs to generate molecular properties
(descriptors) for Structure-Activity Relationship (SAR) analyses
which are too time-consuming to compute manually (e.g., CHEMLAB);
(4) physical/chemical property estimation programs such as
CHEMEST derived from SAR research; (5) environmental fate and
exposure models to predict environmental concentrations of
chemicals and estimate population exposures; and (6) dose-
response models which are used to describe risks, extrapolate
risks from high to low doses, and to estimate health impacts of
particular exposure levels and doses.
Mathematical models may be of many different forms, and
include models based on statistically developed correlations such
as nonlinear dose-response models, as well as complex mechanistic
multimedia environmental fate models.
In the paragraphs that follow, three major types of
analytical capabilities are discussed. These capabilities are:
o Structure-Activity Relationship (SAR)
o Fate and Exposure Modeling
o Dose-Response Modeling
The discussion on SAR includes General Statistical Programs
(e.g., SAS), Multivariate Data Analysis (e.g., ARTHUR), SAR
Descriptor Generators (e.g., CHEMLAB), and Estimation Techniques
(e.g., CHEMEST, CLOGP). Following each discussion, a table is
included identifying the individual models or techniques that
belong to each of the capabilities. Finally, there are two
matrices matching the various classes of models and techniques
against OTS functions and processes respectively. The purpose of
these matrices is to indicate how these capabilities are used.
-------
VI-2
Structure-Activity Relationships
Structure Activity Relationships (SAR) are often established
through statistical methods to relate the presence of specific
chemical structural features to a given biological activity or
other expression of a chemical's nature, such as its physical/
chemical properties. These properties/activities can also be
correlated with one another as in the case of boiling point and
vapor pressure, or octanol/water partition coefficient and bio-
concentration factor. A wide range of statistical programs can
be used to mathematically investigate and describe structure-
activity relationships, depending on their complexity. For
simple and multiple linear regressions, any one of a number of
widely available statistical programs may be used. The most
notable example of such programs commonly used within OTS is
probably the Statistical Analysis System (SAS), resident on the
NCC IBM and planned for implementation on the OTS VAX and IBM
4341 computers. SAS, in addition to its large variety of
univariate, data management, and graphics procedures, also
includes multivariate data analysis capabilities needed for more
complex structure activity analyses. Another program newly
available on the NIH/EPA Chemical Information System (CIS)
entitled ARTHUR features a variety of methods for performing
exploratory multivariate data analyses, including several
clustering analysis techniques.
The CHEMLAB program on CIS provides a way of generating
several molecular descriptors such as molecular volume and
surface area which may be useful in SAR investigations. These
descriptors are usually difficult and time-consuming to calculate
and hence have not been widely used in quantitative SAR (QSAR)
research except for drug design. CHEMLAB thus offers OTS
researchers the capability to use a wider range of molecular
properties in the development of QSARs.
Once these statistical relationships have been codified and
incorporated into a procedure or computer program which allows
scientists to readily calculate the value of one feature from the
values or presence of one or more others, it is often referred to
as an estimation technique.
Estimation techniques are thus the product of research into
structure-activity relationships which allow a reasonably
reliable quantitative estimate to be generated on a regular
basis. While much work has been and is being performed in the
SAR area, relatively few such analyses have resulted in the
development of useful estimation techniques. These are mostly
found in the area of physical/chemical property estimation,
although some work in the environmental fate and ecological
effects areas has also been useful in OTS risk analyses. In
general, health effects SAR research has not yet generated many
-------
VI-3
useful quantitative relationships applicable in OTS work,
although much significant work has been done in the area of drug
design.
The OTS use of analytical capabilities relating to SAR
involves both development and application areas. Estimation
technique programs such as CLOGP and CHEMEST are applied in many
of the chemical assessment activities of the office. A
validation effort has been undertaken in FY 83 to assess the
performance of the estimation techniques for classes of chemicals
frequently encountered in PMN submissions. This work could also
serve as a basis to extend existing estimation techniques to
wider classes of chemicals and to develop new relationships for
use in risk assessment.
-------
VI-4
Structure-Activity Relationship (SAR)
Analytical Capabilities
SAR Development
General Statistical Programs (e.g., SAS)
Specialized Statistical Programs (e.g., ARTHUR)
Descriptor Generators (e.g., CHEMLAB)
SAR Application
CHEMEST (boiling point, vapor pressure, water solubility,
Henry's Constant, volatilization from water half-
life, activity coefficient, adsorption
coefficient, bioconcentration factor)
CLOGP* (log octanol water partition coefficient)
*This program requires the input of chemical structural data
using either the SPILES or SMILES entry programs.
-------
VI-5
Fate and Exposure Modeling
OTS uses a variety of models to assess chemical fate and
environmental or human exposure. These models predict the
concentrations of chemicals in air, water and soil or a
combination of environmental media. In a few cases, they also
include programs to estimate the number of persons potentially
exposed at specific levels. The models are used for screening-
level applications as well as for detailed exposure analyses.
There is an ongoing effort to develop or acquire, implement
and integrate models with data as part of the Graphical Exposure
Modeling System (GEMS). This system, which also includes the
CHEMEST and CLOGP property estimation program, is designed to
give scientific users ready access to models, estimation
techniques, data analysis, data management, and display
capabilities. GEMS users are not required to be familiar with
most of the computer-related aspects of running models; a
subject-area knowledge plus a general familiarity with the
program's features are usually sufficient to perform analyses.
The program prompts users for English-language inputs and
provides specific help information when necessary, thus allowing
users to access data, run models or estimations and analyze
results without using typical computer programming techniques.
The GEMS data bases are included in Section II. The
estimation techniques and models available through GEMS are
discussed in this section. A list of physical chemical
properties which can be estimated using CHEMEST is included in
the table entitled Structure-Activity Relationship: Analytical
Capabilities. The table entitled "Fate and Exposure Models"
lists the models available in GEMS by environmental media. In
addition to the GEMS models, OTS has acquired a number of other
models which also reside on the VAX 11/780 computer. These are
much less frequently used than the first group/ and hence have
not yet been implemented in GEMS. They may be used for specific
assessments as needed by creating special input data files.
Because of this infrequent use, they are not discussed here in
detail, with the exception of the Unified Transport Model-Toxics
(UTM-TOX) which is planned for inclusion in GEMS in FY 84.
-------
VI-6
Fate and Exposure Models
Models in GEMS
Additional Models Available*
Atmospheric
ATM80**
BOXMOD80**
PTDIS
PTMAX
APRAC, CDM, CDMQC, CRSTER,
HIWAY, PTMTP, PAL, VALLEY,
RAM
Surface Water
EXAMS
PEST, RIVMOD, EXAMS2
Soil Water or Runoff
SESOIL
PRZM, ARM
Groundwater
AT123D
Multimedia
ENPART
TOXSCREEN
CJTM-TOX
* These models have implemented on the VAX 11/780 and may be used
outside of the GEMS environment.
**These models outputs include population exposures.
-------
VI-7
Dose-Response Modeling
Unlike fate/exposure models, which use, for the most part,
deterministic simulations of environmental processes, dose-
response models are typically stochastic representations of
relationships between dose level and toxic effect(s). Ordinarily
the "models" represent cumulative distribution functions of
response conditional on dose. Several models currently in use
presume tolerance distributions among individuals' responses.
Others may functionally correspond to postulated biological
mechanisms even though they have been developed totally from data
description principles. Data from animal bioassay tests are
usually input to the models, which use different statistical
assumptions about the form of the relationship to estimate the
probability a dose level is associated with a certain effect
and/or how long it will be until the effect is manifested. To
date, carcinogenicity is the effect which has been modeled most
frequently in this manner.
The various computerized modeling programs are being unified
by common input requirements and output variables. Interfaces
with SAS graphics routines are being developed.
-------
VI-8
Dose-Response and Risk Estimation Models
Probit
MANTELAN
RISK 81
LOGIT
RISK 81
WEIBULL
RISK 81
WEIBULL 82
Multihit
MULTI80 G
RISK 81
One-Hit
ONE HIT MD
GLOBAL 82
MULTI 80 G
Multistage
GLOBAL 82
RANK 81
TIME-TO-OCCURRENCE
MRST
RANK 81
-------
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-------
VII-1
VII. DATA CATEGORIES, DATA SUB-CATEGORIES/
INFORMATION RESOURCE MATRIX
This section presents three sets of matrices which match
respectively data categories and sub-categories (described in
Section IV) against major information resources. While non-
bibliographic computerized information resources are matched
against data sub-categories, both the bibliographic data bases and
manual resources are indexed by data categories only. It would
have been technically infeasible to match bibliographic data bases
and manual resources against data sub-categories.
The purpose of the matrices is to document the types of
information (i.e. data categories or data sub-categories)
available in the major information resources. By comparing these
matrices against the data sub-categories/OTS functions matrices in
the next section, information gaps may be easily seen.
The first set of matrices matches data sub-categories against
computerized non-bibliographic data bases and computer models.
This set of matrices establishes the relationship between infor-
mation resources and data by indicating the specific types of
data, i.e., data sub-categories that are available in these
information resources. In using these matrices, the readers may
want to consult simultaneously the resource attributes matrices in
Section V in order to obtain a complete understanding about the
availabilities as well as searchabilities of data.
The second set of matrices matches data categories against
computerized bibliographic data bases. This establishes the
availabilities of major types of data, i.e. data categories, in
the bibliographic data bases. Again, the readers are urged to
consult the resource attributes matrices on bibliographic data
bases in Section V.
The third set of matrices in this section matches data
categories against manual information resources. A matrix outline
is included in this section. For each of these manual sources
listed in the matrices, its major search attributes are included
and indexed. Note that these attributes are few but are
significantly different from those listed in Section V for the
computerized information resources. Wherever a manual source is
available at the OTS Technical Information Center, it is so
indicated in the matrices.
-------
VII-2
When scanning the Matrix, the reader must use the "OTS
Printed Resources Attributes Matrix Definitions" included in this
section in order to decode the information presented.
The citation number (last column) on the matrix refers the
reader to the full bibliographic citation in the "Author Index" .
Also included in this chapter is the "Glossary of
Abbreviations" which is useful in deciphering the linguistic
shorthand associated with this and other chapters.
-------
VII -9
OTS INFORMATION MATRIX BIBLIOGRAPHIC
DATABASES DATA CATEGORIES
SYSTEM TYPE/NAME
BIBLIOGRAPHIC DATABASES
DIALOG DATABASES (CONT.)
HARFAX INDUSTRY DATA SOURCES
IRL LIFE SCIENCES COLLECTION
ISMEC
NTIS
OCEANIC ABSTRACTS
PAPERCHEM
POLLUTION ABSTRACTS
PTS F&S INDEXES
PTS INTERNATIONAL FORECASTS
PTS PROMT
PTS U.S. FORECASTS
SCISEARCH
SURFACE COATINGS ABSTRACTS
TEXTILE TECHNOLOGY DIGEST
TRADE AND INDUSTRY INDEX
WATER RESOURCES ABSTRACTS
MEDLARS DATABASES
CANCERLIT
CANCERPROJ
MEDLINE
TOXLINE
ORBIT DATABASES
BIOSIS
CA SEARCH
ENVIROLINE
FEDERAL REGISTER
NTIS
APIPAT
\iS. CLASS
CHEMICAL
ACCESS
NO. CHEMICALS
347K
21 K
800K
570K
3M
K
8
u
X
X
X
X
X
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
J2
u
UJ
Ik
Ik
111
_l
111
z
K
>
X
111
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
USE/DISPOSAL
X
X
X
X
X
X
X
X
X
u
u
X
u
u
u
EXPOSURE
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ECONOMICS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
-------
VII-10
OTS INFORMATION MATRIX BIBLIOGRAPHIC
DATABASES DATA CATEGORIES
SYSTEM TYPE/NAME
BIBLIOGRAPHIC DATABASES
ORBIT DATABASES (CO NT.)
USPA
WPI/WPIl
TULSA
TSCA PLUS
MISCELLANEOUS DATABASES
EMIC (ORNL)
ETIC (ORNL)
NIOSHTIC
RAPRA ABSTRACTS (PERGAMON)
CHEMICAL
ACCESS
NO. CHEMICALS
58,000
CASRN
X
X
X
X
OTS DATA CATEGORIES
Z1
o
u
z
UJ
a
UJ
u
z
1
tn
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
en
h-
U
Ul
u.
u.
UJ
X
<
UJ
X
X
X
X
ENVIRONMENTAL EFFECTS
ca
1
u
o
-------
Vll-li
OTS PRINTED RESOURCES ATTRIBUTES
MATRIX OUTLINE
I. Chemical Access
A. No. (of) chemicals
B. CAS Registry Number (CAS RN)
II. OTS Data Categories
A. Substance Identification
B. Physical-Chemical Properties
C. Health Effects
D. Environmental Effects
E. Production/Processing
F. Use/Disposal
G. Exposure
H. Economics
I. Regulations/Control
III. Publication Location
A. Publication Type
B. Supplements
C. Frequency of Revision
D. Online Version
IV. Shelf Locations
A. LC Call Number
V. Author Index
A. Citation Number
VI. Glossary of Abbreviations
-------
VII-12
OTS PRINTED RESOURCES ATTRIBUTES MATRIX
DEFINITIONS
I. Chemical Access:
denotes access to a limited number of chemicals or to specific
chemical identification.
I.A. No. (number of) chemicals:
denotes scope of coverage of chemical substances; an (*)
asterisk denotes an undetermined number of chemicals are covered.
I.E. CAS RN:
denotes Chemical Abstract Service Registry Numbers are
associated with the chemical nomenclature.
II. OTS Data Categories:
general areas of chemical information requirements of OTS. (See
Section IV of the notebook.)
II.A. Substance Identification:
information is available to establish the identity of a
chemical substance as defined by TSCA.
II.B. Physical-Chemical Properties:
characteristics of substances related to reactivity.
II.C. Health Effects:
contains human/animal toxicity data as well as biological and
physiological effects of chemical substances.
II.D. Environmental Effects:
contains data that OTS needs in evaluating the environmental
effects of chemical substances.
II.E. Production/Processing:
the processing of a chemical substance through the environment,
includes source of emissions, amount produced, where and how a
substance is produced.
II.F. Use/Disposal:
contained and dispersed uses of chemical substances and disposal
methods. U = use data only, D = disposal data only, X = both
use and disposal data
-------
VII-13
II.G. Exposure:
release, fate, populations, monitoring and geographic location
of chemical and general substances.
II.H. Economics:
production, distribution, consumption of chemical substances.
II.I. Regulations/Control:
laws, standards, guidelines.
III. Publication Information:
features related to the printed source.
III.A. Publication Type:
1 - Handbook
2 - Monograph
3 - Encyclopedia
4 - Index
5 - Dictionary
6 - Other
III.B. Supplements:
continuation of the printed resource
III.C. Freq(uency) of Revision:
related to a time schedule followed for incorporating changes
into the text.
1 - weekly
2 - monthly
3 - annually
4 - every 2-3 years
5 - every 4-5 years
6 - infrequent
III.D. Online Version:
printed source in whole or part is computerized and available
interactively.
IV. Shelf Location:
Most resources are located in the OPTS Technical Information
Center (TIC) E447, or EPA Headquarters Library M2404; other
sources can be obtained on Interlibrary loan.
-------
VTI-14
IV.A. LC Call Number:
Library of Congress call number is given to help locate the
printed sources. The call number is interpreted as follows:
1 - a (*/) check after the call number indicates the book is
in the TIC.
2 - an (*) asterisk following the call number indicates the
book is in the HQ Library.
3 - ( ) brackets around the call number indicates an inter-
library loan is necessary.
V. Author Index:
Full bibliographic citation.
V.A. Citation Number:
Reference number which leads the user from the Handbooks/Printed
Sources Matrix to the author index.
VI. Glossary of Abbreviations:
Definitions of abbreviations and acronyms appearing in the
matrices.
-------
VIM 5
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
ACCIDENT PREVENTION MANUAL FON INDUSTRIAL . . .
ACUTE TOXICTY IN THEORY AND PRACTICE . . .
ADSORPTION OF POLYCHLOMNATED BIPHENYL . . .
ADVANCES IN FORENSIC AND CLINICAL . . .
ADVANCES IN MODERN TOXICOLOGY. VOL 1, FT. 1
ADVANCES IN MODERN TOXICOLOGY. VOL 4
ADVANCES IN MODERN TOXICOLOGY. VOL S
ADVANCES IN NEUROTOMCOLOGY
ADVANCES IN PHARMACOLOGY AND .. .11 VOL V
ADVERSE EFFECTS OF ENVIRONMENTAL ... VOL 2
AEROSOLS. AIRWAYS AND ASTHMA
AGRICULTURAL CHEMICALS AND PESTICIDES . . .
AGRICULTURAL RUNOFF MANAGEMENT . . .
AIR POLLUTION
AIR POLLUTION. 3 ED: VOL 1
AM POLLUTION. 3 ED: VOL 1
AIR POLLUTION. 3 ED; VOL II
AIR POLLUTION. 3 ED: VOL IV
AIR POLLUTION. 3 ED: VOL V
AIR POLLUTION FROM PESTICIDES AND AGM . . .
THE AMPHETAMINES: TOXICITY AND ADDIC . . .
ANALYTICAL TOXICOLOGY METHODS MANUAL . . .
ANALYTICAL TOXICOLOGY METHODS MANUAL
ANNULS IN TOXICOLOGY RESEARCH. 1ST ED. ...
AN ANNOTATED ACCESSION LIST OF DATA . . .
AN ANNOTATED BIBLIOGRAPHY OF COMPILED . . .
ANNUAL REVIEW OF PHARM. AND TOXICOLOGY. VOL. 1
ANNUAL REVIEW OF PHARM AND TOXICOLOGY. VOL 1)
ANNUAL REVIEW OF PHARM. AND TOXICOLOGY. VOL. 17
ANNUAL REVIEW OF PHARM. AND TOXICOLOGY. VOL. 1)
ANNUAL REVIEW OF PHARM. AND TOXICOLOGY. VOL. IS
ANNUAL REVIEW OF PHARM. AND TOXICOLOGY. VOL 2)
ANNUAL REVIEW OF PHARM. AND TOXICOLOGY. VOL 21
ANNUAL REVIEW OF PHARM. AND TOXICOLOGY. VOL 22
AQUATIC AND ENVIRONMENTAL QUALITY: PROBLEMS
AQUATIC TOXICOLOGY. VOL 1
AQUATIC TOXICOLOGY AND HAZARDOUS ASS ...
AQUATIC TOXICOLOGY AND HAZARDOUS ASS ...
AQUATIC TOXICOLOGY AND HAZARDOUS EVAL . . .
AQUATIC TOXICOLOGY. PROCEEDING OF 2ND ANNUAL . . .
AQUATIC TOXICOLOGY. PROCEEDING OF 3RD ANNUAL . . .
AROMATIC HYDROCARBONS MANUFACTURE . . .
ASSESSING TOXIC EFFECTS OF ENVIRONMENTAL . . .
ASSESSMENT OF AMBORNE PARTICLES: FUNDAM . . .
ASSESSMENT OF INDUSTRIAL HAZARDOUS . . .
ATMOSPHERIC CHEMISTRY MODELLING
A BASIC TOXICITY CLASSIFICATION OF ...
BEHAVIOR OF ORGANIC CHEMICALS IN THE ...
BEILSTEIN'S HANDBOOK OF ORGANIC CHEM . . .
CHEMICAL
ACCESS
NO. CHEMICALS
*
*
1
*
*
*
*
-ISO
*
*
*
*
*
*
*
*
*
*
N/A
*
*
*
*
#
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
-TOO
*
CASRN
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ENVIRONMENTAL EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
X
X
USE/DISPOSAL
u
u
X
u
o
D
D
D
X
X
u
u
u
u
u
D
u
D
EXPOSURE
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ECONOMICS
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUBLICATION TYPE
1
2
B
1
1
1
.2
1
2
1
1
B
1
1
1
1
2
2
1
2
B
B
B
B
B
)
B
B
B
1
1
B
B
B
)
)
1
1
B
)
B
1
1
1
e
i
&
X
FNEO. OF REVISION
i
B
B
1
B
B
)
)
B
B
B
B
B
)
)
B
B
B
B
B
3
3
3
3
3
3
3
3
B
)
B
B
B
B
B
B
B
B
B
2
B
B
ON LINE VERSION
X
SHELF
LOCATION
[TSU1 1*74]
RAI27ILPU77/
RA1211.CS*
M119M4I*
RL72.047-
OH4H.CSMI7-
RC347.H5V
RA11SO*37v'
[RCBB1A33 1SS1]
•'DIS3.SI3*
TOB*3.S»3-
TDBS3.SB3-
TDIS3.SS3-
TDSBUI3*
TD8S7J>4SA3Bv'
[RA1242A6K3]
[RA 1221 AS]
[RA1221ABSUPPL]
[RA11M.A64 1912]
acioo.usT/
RMlB.AUv'
HMUJWSv'
RMIB.ASSv'
RM1BJW3>/
BMIB.ABJ.'
RMIS.ANv'
RMIS.Wv'
RMU.AS3/
[TD2ZI.H37]
[QHS4S.W3ABB]
QHS4B.W3.AMv'
OH646.W3.S96v'
OH546.W3.S96v'
QHM6.W3SS6v/
aH546.W3S9Sv'
QD341H96)E17v/
RAB7)A2AB7v'
[00649JI6*]
[WNBB01ND]
TD427.B7W3-
[GD2S1.B42B44]
AUTHOR
INDEX
CITATION NUMBER
317
72
1*1
114
2B6
272
IBS
2B7
4K
204
421
14*
12*
464
40*
40*
407
40*
41)
240
221
40)
3N
46
4CB
17
142
143
144
1)7
1H
IB*
17)
171
11)
4*4
69
33*
277
21)
140
3*3
241
290
23)
84
20)
3*4
49
-------
VIM 6
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
BEHSTEirS HANDBOOK Of OR8AMC CHEN . . .
BENZINE TOXICITY: A CRITICAL EVAIUATXM
BIOCHEMICAL TOXICOLOGY OF ENVIRONMENTAL . . .
BIOCHEMISTS' HANDBOOK
BYCONVERSION: FUEL FROM BOMASS
BtODEGRAOATION AND DETOXIFICATION OF ...
BMOEGRAOATION OF PESTICIDES
•ODE6RAOATION OF POLYMERS AND ...
BMOEGRAOATION TECHNIQUES FOR INDUSTRIAL . . .
BtODETERIORATION: 4TH INTL. SYMPOSIUM
BIODETERIORATION: 5TH INTL SYMPOSIUM
BIOOETERHINATION OF MATERIALS. VOL 1
E400ETERIORATION OF MATERIALS. VOL H
BIOLOGICAL ABSTRACTS
BIOLOGICAL MONITORING FOR INDUSTRIAL. . .
BIOLOGICAL REACTIVE INTERMEDIATES . . .
BULLETIN OF THERMODYNAMICS AND ...
BURGER* MEDICINAL CHEM. 4TH ED: ITS. I. II. II
CRC ATLAS OF SPECTRA DATA AND PHYSICAL ... 2ND ED
CRC HANDBOOK OF ANALYTICAL TOXICOLOGY
CRC HANDBOOK OF CHEN. AND PHY. S2NO ED.
CRC HANDBOOK OF LABORATORY SAFETY. 2ND ED.
CRC HANDBOOK SERIES IN NUTRITION AND FOOD . . . VOL. 1
CRC PERSISTENT PESTICIDES IN THE ENV . . .
CADMIUM TOXICITY
CARCMOGENESIS AND MUTAGENESIS
CARCMOGENESIS TESTING PROGRAM
CARCMOGEN AND CHRONIC TOXIC HAZARD . . .
CARDIAC TOXICOLOGY. VOL 1
CARDIAC TOXICOLOGY. VOL »
CARDIAC TOXICOLOGY, VOL IN
THE CARE. HANDLING AND DISPOSAL OF ...
CASARETT AND DOULL'S TOXICOLOGY; THE ...
CATALOG OF TERATOGENIC AGENTS. 2ND ED
CELLULAR BIOLOGY AND TOXICITY . . .
CHEM. SOURCE U.SJL
CHEM CYCLOPEDIA
CHEMICAL ABSTRACTS
CHEMICAL AND ENGMEERMG NEWS ...
CHEMICAL CARCINOGENS
CHEMICAL COMPOS. IN THE ATMOSPHERE
CHEMICAL CONSTITUTIONS. INTERMEDIATE . . .
CHEMICAL ECONOMIC HANDBOOK
CHEMICAL ENGINEERS1 HANDBOOK
CHEMICAL HAZARDS TO HUMAN REPRO . . .
CHEMICAL MARKETIN8 REPORTER
CHEMICAL MODELING IN AQUEOUS SYSTEMS
CHEMICAL MUTAGENS
CHEMICAL PROFILES
CHEMICAL REFERENCE MANUAL VOL 1
CHEMICAL
ACCESS
m
*
1
*
*
4
*
91
*
*
*
*
*
*
*
*
*
*
*
29.000
~U3S
-20.000
*
*
*
1
*
273
*
*
*
*
-620
*
-909
*
*
*
*
SO
*
71MB
*
~U»!
~2S
*
*
*
*
15K
i
X
OTS DATA CATEGORIES
WMTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
•J
38
IE
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
e
lit
it
ttl
i
I
IU
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ffl
i
X
X
X
X
X
X
X
X
X
X
i
X
D
u
u
X
u
u
u
X
u
u
u
u.
u
D
lit
c
111
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
i
X
X
X
X
X
X
X
^
a
I
X
X
X
X
X
1
X
X
PUBLICATION
INFORMATION
r
I
1
2
1
1
1
1
9
2
3
1
1
1
1
6
1
1
1
1
1
1
1
1
1
2
1
2
2
2
2
2
2
2
1
1
1
4
1
1
1
2
1
2
1
1
1
1
1
2
1
1
5
X
X
i
s
2
E
7
1
1
1
1
1
1
1
1
6
1
2
1
1
1
1
s
3
1
6
1
1
1
1
1
1
1
1
1
1
1
1
3
3
1
3
1
1
s
i
1
1
1
1
1
6
1
s
I
X
X
SHELF
LOCATION
i
u
•J
(G02SIJ42B45)
[RA1242J4B4I
RAIHUfV
MFOD24616,/
[7784176]
OJHS.BUy
[SB9tl.14t.B54IM]
aptnjtuy
(TDin.SBM]
[QH530.SI57]
[OH6J9.SK7]
[TM1I.74J57]
TA41I.74.I67-
-
RB«lS6y
RA1191.BSI'
[QD51I.T4B2]
BS.W3BI,/
tOD2S1.CH]
RA1221.CW
OD96.H3,/
QD61.SM-
[RC820JUM7]
OH54S.P4E3V
QV290.C12IV
[OP97I.S3]
RCSI2.C3iy
RCM2.C3S./
RCH2.C3B
[TP.14LG24]
RAI211.C2H
QM 911 583
[RD7I.3.C46]
[TPI2.C44]
[TP12.C4S]
RC2HJC4I-
O.CS79JG73'/
TP9IOJ92/
HMMM.S.79/
TP151.C62
V2S1.CS
aD38JJH3C*iy
ttH431.FS7y
[QD77M130]
AUTHOR
INDEX
S
!
so
237
111
2B2
369
19
274
377
119
330
329
4BB
411
M
249
219
419
498
192
419
493
403
383
141
2B7
2B4
304
374
39
37
31
1H
131
371
1S2
11
3
9
239
376
179
106
396
339
101
372
217
164
373
261
-------
VII-17
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
CHEMICAL REGULATION REPORTER. CURRENT . . .
CHEMICAL REGULATION REPORTER. HAZARDOUS . . .
CHEMICAL REGULATION REPORTER. INDEX . . .
CHEMICAL REGULATION REPORTER. HEF . . .
CHEMICAL REVIEWS
CHEMICAL SAFETY DATA SHEETS
CHEMICAL STRUCTURE AND PROPERTIES . . .
CHEMICAL SOURCE EUROPE
CHEMICAL STUDIES ON BENCHWORX
CHEMICAL TECHNOLOGY: AN ENCYCLOPEDIC ... IV
CHEMICAL WASTE DISPOSAL AND ...
CHEMICAL WEEK 1971 BUYER'S GUIDE . . .
CHEMICAL ZOOLOGY, VOL Ml
CHEMISTRY AND MODE OF ACTION . . .
CHLORINATED INSECTICIDES, VOL II
CIS INDEX TO PUBLICATION OF THE U.I ...
CLINICAL TOXICOLOGY, 2ND ED
CLINICAL TOXICOLOGY MANUAL
CLINICAL TOXICOLOGY OF AGRICULTURAL . . .
CLINICAL TOXICOLOGY OF COMMERCIAL . . .
CLINICAL TOXICOLOGY OF DRUGS: PRIN . . .
COMPREHENSIVE INORGANIC CHEM. VOL 1-5
COMPREHENSIVE ORGANIC CHEM, VOL t-8
COMPREHENSIVE ORGANOMETALUC . . . VOL. I-S
CONCISE CHEMICAL AND TECH. DICTION . . .
CONDENSED CHEMICAL DICTIONARY
CONTAMINANTS 1 SEDIMENTS. VOL 1
CONTAMINANTS t SEDIMENTS. VOL 2
COPPER IN BIOLOGY AND MEDICINE . . .
CIOTEMA FOR ORGANOCHLORME PEST. . .
CRITERIA FOR A RECOMMENDED . . .
CRITICAL EVALUATION OF DATA IN ...
CRITICAL MICELLE CONC OF AQUEOUS ....
A CRITICAL REVIEW OF RECENT LIT. ON ...
CRITICAL STABILITY CONSTANTS, VOL 1
CRITICAL STABILITY CONSTANTS. VOL II
A CRITIQUE OF ACCEPTED RED. AND . . .
CURRENT APPROACHES IN TOXICOLOGY
CURRENT CONCEPTS IN CUTANEOUS . . .
CURRENT INTELLIGENCE BULLETIN. 19-30
CUTANEOUS TOXIdTY
DANGEROUS PUNTS, SNAKES. ARTHROPODS . . .
DANGEROUS PROPERTIES OF INDUSTRIAL . . .
DEGRADATION OF SYNTHETIC ORGANIC . . .
DERMATOTOXICOLOGY. 2ND EO.
THE DETECTION AND HAZARDS OF ...
DEVELOPMENTAL AND GENETIC ASPECTS . . .
DEVELOPMENTAL TOXICOLOGY
DEVELOPMENTS IN SIOOEGRAOATION OF ...
CHEMICAL
ACCESS
NO. CHEMICALS
*
*
*
*
SJOO
70
11
28.009
*
*
*
*
*
*
*
*
*
*
-17.500
*
*
-20,000
*
-52.000
-390.000
*
*
1
20
-too
*
1
*
*
*
*
*
*
*
-19.000
17
*
*
*
*
*
3
U
X
X
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ENVIRONMENTAL EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
X
I
U
U
U
D
U
U
U
U
U
X
U
U
U
D
U
U
X
U
U
U
U
EXPOSURE
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ECONOMICS
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUBLICATION TYPE
9
t
4
1
1
1
1
4
1
3
1
1
1
1
t
1
1
1
1
1
1
(
1
1
S
5
2
1
2
1
2
1
2
1
1
6
1
1
a
i
1
i
6
2
1
6
2
1
SUPPLEMENTS
X
X
X
X
X
X
X
X
X
V.
o
a
lit
1
9
9
1
9
9
9
3
9
9
9
3
9
9
9
9
9
9
9
9
9
9
9
9
9
9
B
9
9
9
9
9
B
9
S
9
9
9
9
9
9
9
9
3
9
9
ONLINE VERSION
X
SHELF
LOCATION
c
IU
m
-i
<
U
U
-1
[KF38HJUMA7I
[KF3SHJUEOA7I
[KF396SA15BA7]
[XF39M.A16BA7]
[RA1270.M29]
REFTP12.C517-
TP200.NBS-
[TP1Z.C43]
QPS14JS29y
SBSS2.C44B79
T66.3.H3B73
[RA 1211.P9]
[RA 121 1.0393]
[RH1210AHW33]
RA1211.GS./
[RA123S.CS4.]
REFOD161.2CM'
aoM.cn/
[OJM11.C9«]
OD5.B4./
OD6.CW
T0196.D72CI9-/
TD196.D72C6Sy
[OK3S.CS093)
RAI270J>4C74/
OC100.Ui753y
aC100.U67v/
[SH.L77C93D99]
[OD.Sa3M.37I
[OD.M3M.37]
RA1211.CS79-
[RL31.CB23]
[QD.S03.M.37]
Miisuai./
[Oil OO.E44 1979)
T5U.H3S3V
QP817JBD44-
[RL72.D471993]
TD172.MM
RA119I.EI-
[OD3M.H50392]
AUTHOR
INDEX
CITATION NUMBER
29
23
27
25
242
2H
159
92
93
102
402
279
159
101
71
107
343
117
499
17S
3S9
30
44
169
51
191
33
34
329
291
309
3S3
302
130
270
271
as
41
134
311
133
149
370
314
273
10
137
492
-------
VIM 8
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
DEVELOPMENTS M TOXICOLOGY ADO ...
DICTIONARY OF ORGANIC COMPOUNDS . . .
DIRECTORY OF CHEMICAL PRODUCERS . . .
DISPOSITION OF TOXIC DRUGS AND ...
DISPOSITION OF TOXIC ORU6S AW ...
DISPOSITION OF TOXIC DRUOS AND ...
DISSOCIATION CONSTANTS OF INOR6ANIC . . .
DISSOCIATION CONSTANTS OF ORGANIC . . .
DOCUMENTATION OF THE THRESHOLD . . .
DRUG EFFECTS IN HOSPITALIZED . . .
DRUG INDUCED CLINICAL TOXIdTY . . .
EASTMAN ORGANIC CHEMICAL BULLETIN
ECOLOGICAL ASPECTS OF TOMCITY TESTING . . .
ECOLOGICAL TOXICOLOGY RESEARCH: EFFECTS . . .
ECONOMIC ANALYSIS OF EFFLUENT . . .
EFFECTS AND OOSE RESPONSE RELATIONSHIPS . . .
EFFECTS OF CHRONIC EXPOSURE TO ...
EMERGENCY HANDLING OF HAZARDOUS . . .
ENCYCLOPEDIA Of CHEMISTRY
ENCYCLOPEDIA OF CHEMICAL TECHNOLOGY
ENCYCLOPEDIA OF ENVIRONMENTAL SCIENCE . . .
ENCYCLOPEDIA OF OCCUPATIONAL. . .
ENCYCLOPEDIA OF POLYMER SCIENCE AND ...
ENERGY FROM BYCONVERSION OF ...
ENVIRONMENT AND BIRTH DEFECTS
ENVIRONMENT REPORTER
ENVIRONMENTAL AND OCCUPATIONAL . . .
ENVIRONMENTAL CHEMISTRY
ENVIRONMENTAL ENGINEER'S HANDBOOK
ENVIRONMENTAL FATE AND...
ENVIRONMENTAL HAZARDS OF METALS: . . .
ENVIRONMENTAL HEALTH CRITERIA
ENVIRONMENTAL ISSUES REPORT 10
ENVIRONMENTAL LAW REPORTER
ENVIRONMENTAL POLLUTION ANO TOXICOLOGY
ENVIRONMENTAL SCIENCE RESEARCH . . .
ENVIRONMENTAL TOXICOLOGY: PRINCIPLES . . .
ENZYMATIC BASIS OF DETOXIFICATION. VOL 1
ENZYMATIC BASIS OF DETOXIFICATION. VOL 2
EPIDEMIOLOGY AND DETECTION OF ...
ESSAYS M TOXICOLOGY. VOLS. 1-7
ESSAYS IN TOXICOLOGY. VOL 1
ESSENTIALS OF TOXICOLOGY
EVALUATION OF TOXICOLOGICAL DATA . . .
EXPERMENTAl ANO CLINICAL . . .
FAO INVENTORY DATA ON ...
FAITH, XEYES AND CLARK* INDUSTRIAL . . .
FATE OF POLLUTANTS IN THE AIR ... PART 1
CHEMICAL
ACCESS
NO. CHEMICALS
*
-1.3BO
-10.00!
712
712
*
217
3.7N
*
*
*
*
*
~M
-108
*
*
*
*
*
*
*
*
*
*
*
*
*
*
~I2
*
*
5
*
*
*
*
*
*
1
*
*
0
*
*
*
140
*
*
u
X
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
u.
UJ
i
w
X
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
X
X
X
X
X
X
USE/DISPOSAL
u
u
u
u
u
X
u
u
X
u
u
o
u
X
X
u
u
u
u
EXPOSURE
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ECONOMICS
X
X
X
X
X
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUBLICATION TYPE
1
B
1
1
1
1
1
1
1
1
2
1
1
1
1
1
1
1
3
3
3
3
3
S
2
B
1
1
1
B
2
2
6
6
2
1
1
2
2
1
2
B
1
6
3
B
1
B
|
1
X
X
X
FREO. OF REVISION
1
B
B
B
B
B
B
2
B
1
B
B
B
B
1
B
B
B
B
B
B
1
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
ONLINE VERSION
SHELF
LOCATION
LC CALL NUMBER
RAIISUSiV
OD2S1.D4Sy
TP12J)64^'
[RA122.B37 I9B2]
[RA122J37 I9B2]
[RA 1221 .637]
JM1BA3/
00273.P3EV
RAUtlABV
[RM2B2.0BB]
[RA 1231.0794]
Omil.lMUSv'
OH64t.M4tN37y
RA1231.M52E33"
[RAU70.P4E34 1913)
[T55JH3AAR]
ODS.EU/
TPt.EBSBv'
TAITOfS*
[RC963JB1
TPIMPOEt^
TP782JJ47/
RBIB2.WIV
KF377S.ABE49-
OJM91.S53,/
(0031 .2M3S]
TD14S.E67-
RA1231.MI2BBB13
GF76.EBS/
RA1216.R58v/
[RA119115S1
QPSOLESISy
QP«OI.E515y
[RA 1231 MEM]
RA1190.E77y
RAH90.E77v'
RA1 211.18^
RA119S.CS4y
RC347.E99./
[SH1.FB71B1
TP2DO.F3./
TD180-AM./
AUTHOR
INDEX
CITATION NUMBER
477
425
3B7
4B
a
47
33S
337
1
29B
2S2
139
64
2BO
20
321
B7
415
IBB
113
340
211
2BB
11B
47B
26
381
2B2
251
257
BS
4B7
202
354
352
486
394
212
213
1SB
1*3
57
253
20*
397
141
255
417
-------
VIM 9
.OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
FATE OF POLLUTANTS W THE AM ... PART 2
FATE OF SELECTED PESTICIDES III THE ...
FENAROLCS HAWBOOK OF FLAVOR . . .
FIFTEEN JAAR ZELFVF.RGIFTIGINGEN 11 ...
FINAL TREATMENT: THE FILE OR DR. X
FINDING FUNGACITY FEASIBLE
FLUORINE AND DENTAL HEALTH: THE ...
FORENSIC TOXICOLOGY
FORENSIC TOXICOLOGY: CONTROLLED . . .
FORENSIC TOXICOLOGY FOR THE LAW ...
FORENSIC TOXICOLOGY: PROCEEDMGS . . .
FUNCTION Toxicrrr OF ANESTHESIA
FURTHER STUDIES IN THE ASSESSMENT . . .
GLOBAL CHEMICAL CYCLES AND THEM . . .
THE GOLDFISH AS A TEST ANIMAL . . .
GOOD LABORATORY PRACTICE: TOPICS . . .
GOVERNMENT CONTRACTS GUIDE
GUIDELINES FOR ANALYTICAL . . .
GUIDELINES FOR ENVIRONMENTAL . . .
HANDBOOK FOR OBTAINING CHEMICAL USE ...
HANDBOOK OF ADHESWES
HANDBOOK OF CHEMICAL PROPERTY ESTIMATION . . .
HANDBOOK OF EMERGENCY TOXICOLOGY
HANDBOOK OF EMERGENCY TOXICOLOGY: A GUIDE . . .
HANDBOOK OF ENVIRONMENTAL CONTROL (CRC)
HANDBOOK OF ENVIRONMENTAL . . . ORGANIC CHEMICALS
HANDBOOK OF EPOXY RESINS
HANDBOOK OF FINE CHEMICALS
HANDBOOK OF IDENTIFIED CARCINOGENS AND ...
HANDBOOK OF INDUSTRIAL TOXICOLOGY
HANDBOOK OF INTERNATIONAL FOOD . . . VOL. 1
HANDBOOK OF INTERNATIONAL FOOD . . . VOL. II
HANDBOOK OF OCULAR TOXICITY
HANDBOOK OF POISONING: DIAGNOSIS . . .
HANDBOOK OF REACTIVE CHEMICAL . . .
HANDBOOK OF SOLVENTS
HANDBOOK OF TABUS FOR ORGANIC COMPOS . . .
HANDBOOK OF TOXIC AND HAZARDOUS . . .
HANDBOOK OF TOXICOLOGY. ACUTE, VOL 1
HANDBOOK OF TOXICOLOGY. ANTIBIOTICS. VOL II
HANDBOOK OF TOXICOLOGY. INSECTICIDES. VOL IN
HANDBOOK OF TOXICOLOGY. FUNGICIDES. VOL. IV
HANDBOOK OF VAPOR PRESSURES AND HEATS . . .
HANDBOOK OF WATER SOLUBLE OUMS . . .
THE HANSCH APPROACH
HAZARDOUS AND TOXIC EFFECTS OF ...
HAZARDOUS CHEMICALS DATA
HAZARDOUS CHEMICALS DATA BOOK
CHEMICAL
ACCESS
NO. CHEMICALS
*
22
-200
*
1
*
1
*
*
*
~3Sfl
-40
*
*
*
*
*
*
*
#
*
*
IIS
*
*
-1.000
*
~12jOflfl
-100
*
*
*
*
*
-7.009
*
71.160
-600
-2JB3
340
164
198
#
*
*
*
*
-400
CASRN
X
X
X
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ENVIRONMENTAL EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
X
X
X
X
USE/DISPOSAL
u
u
u
u
u
u
X
X
D
u
u
u
u
u
X
u
u
u
u
EXPOSURE
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
3
1
s
X
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUBLICATION TYPE
1
6
1
1
1
6
1
1
1
1
1
2
1
1
3
8
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
2
2
1
1
1
SUPPLEMENTS
X
FREQ. OF REVISION
1
1
1
1
1
2
1
1
1
«
1
1
1
1
1
6
1
1
1
1
1
1
1
1
6
1
4
1
1
1
1
1
g
g
g
i
g
g
g
g
g
g
g
g
g
g
g
ON LINE VERSION
SHELF
LOCATION
tc
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TP4H.F3C
ISBN 90 8203-Otg-O
[RA 1229153]
[OPSS1.FKMI]
[RAI22S.F67]
[HVB07317S]
[RA1229.W54]
[RA122IJ57]
[RA1270.AS397S]
OES 15.026 •
(QPMIJ-I)
[RA1199.N 1579]
[KFB4I.C9]
RA12Z1.GS4y
TXS01M7-
TP9N.SU-
[002711961
[RA1211JC3]
[RA 1211 A3]
T014S.C2/
TD196.073V47y
[TP11IO.EgL41
RC2M.6.C7ZW
RA121B.PS6y
[RA1270.F6V47]
[RA1270.P4V47)
[RE901.TB75M
RA1211.D77,/
T55.3.H3373/
TP247J.S32"
BUS 00291 JUI. 1917-
RA1193.S5IV
[RA1211.H32]
RA121t.H32v/
[RA1211.H32]
[RA1211H32]
[OD3HMW64]
TP97t.H29
-------
VII-20
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
HAZARDOUS MATERIALS: EMERGENCY . . .
HAZARDOUS MATERIALS GUIDE: SHIPPING . . .
HEALTH HAZARD EVALUATION SUMMARIES
HERBICIDES: CHEMISTRY, DEGRADATION ... VOL. 1
HERBICIDES: CHEMISTRY, DEGRADATION ... VOL II
HOW TO DISPOSE OF TOXIC SUBSTANCES . . .
THE I/O-CHAMCTEM TO DESCRIBE . . .
MMUNOLOGK CONSIDERATIONS ... VOL 1 1 II
IMPORTS OF BEIZENOID CHEMICALS . . .
INDEX HANDBOOKS OF OTOTOXIC . . .
MDUSTMAl AND ENVIRONMENTAL . . .
INDUSTRIAL CONTROL EQUIPMENT . . .
INDUSTRIAL HYGIENE AND ... VOL II
WOUSTMAl WASTE DISPOSAL
•FORMATION RESOURCES M TOXICOLOGY
MTERHATIONAl ENCYCLOPEDIA OF ...
INTERNATIONAL ENVIRONMENT REPORTER
MTERNATIONAl SYMPOSIUM ON ...
UTRODUCTION TO BIOCHEMICAL . . .
INTRODUCTION TO ENVIRONMENTAL . . .
MTNODUCnON TO FORENSIC TOXICOLOGY . . .
KIN6ZETTS CHEMICAL ENCYCLOPEDIA
KIRK-OTHMER ENCYCLOPEDIA. 2ND ED.
KLINE GUIDE TO THE CHEMICAL . . .
KLINE GUIDE TO THE PLASTICS . . .
KUNE GUIDE TO THE PULP I PAPER . . .
LABOR. 21 CFR 1SI1.I VOL 29 PIS 911 . . .
LABOR 21 CFR 192B.1 VOL 21 PTS 120 ...
LABORATORY MODEL ECOSYSTEM STUDIES . . .
LABORATORY WASTE DISPOSAL MANUAL . . .
LAME'S HANDBOOK OF CHEMISTRY . . .
LEAD TOXIOTY
LIGNIN BIODEGRADATION « TRANSFER
IIGNIN BIODEGRADATION: MICROBIOLOGY . .
MANAGEMENT OF TOXIC SUBSTANCES . . .
MANNSVIIU CHEMICAL PRODUCTS . . .
MATERIALS HANDBOOK. AN ENCYCLOPEDIA . . .
MECHANISM OF TOXIC ACTION IN SOME . . .
MECHANISMS OF ACTIONS OF NEUROTOXIC . . .
MECHANISMS OF TOXIOTY AND ...
MECHANISMS IN RESPIRATORY TOXICOLOGY
MEMBRANE TOXIOTY
MERCK INDEX
METABOLIC INHIBITORS: A COMP . . .
METABOLISM
METABOLISM OF PESTICIDES
CHEMICAL
ACCESS
NO. CHEMICALS
43
*
*
*
*
*
7
«
*
*
-210
*
*
0
*
-60
*
*
*
*
*
*
*
-wo
*
*
0
B
*
1.121
4JDOO
1
1
*
*
20i
*
*
~3fl
*
*
*
-10000
*
*
*
•
i
X
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ENVIRONMENTAL EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
X
X
X
X
X
X
g
D
u
u
X
u
u
u
u
D
X
u
X
U
u
u
u
u
X
i
z
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
§
X
X
X
X
X
X
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUBLICATION TYPE
1
1
B
1
1
1
1
1
B
4
1
1
t
B
B
1
B
1
1
1
B
3
3
1
1
1
B
B
1
1
1
2
1
B
B
1
1
1
2
1
1
6
3
1
1
t
i
Ul
X
FREO. OF REVISION
B
B
B
B
B
B
B
1
1
B
B
«
1
B
B
2
B
1
B
B
B
1
3
3
1
B
1
B
1
B
B
B
B
B
B
B
B
1
B
B
1
ON LINE VERSION
X
SHELF
LOCATION
1C CALL NUMBER
[m3J«4SB
[KF3BMJH4)
RA1242JM3N2Sr
SB961.4.KI/
SBH1.4MV
TD867.P66V
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PU1191JS3]
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[OPB31J>4B)
(JD1S9.1673)
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[RA122BJ6B)
[ODSJM 1SBB]
TP«.E686y
HD6MUKS7
HMM1.US2C4SV'
HD962S.K6S2./
OMB1.P46V'
ODBS1.P4EV
QDB.EBly
DOM.LA,/
RA123614L43-
[OJUSU5C7]
[TS933.LSL6]
BUS OH645>IM353v'
TA«3J76y
RA1190.Eiy
[RC347.M42]
RMZI.IMy
[RC732JM3 I9B2]
[RAIt»JM2]
[RSS1.M4 1SBB]
OPBOIJWBHMy
[SK38IJUW N0.127]
AUTHOR
INDEX
CITATION NUMBER
316
228
312
22B
227
34S
27S
37B
443
4B2
1S7
B1
149
3B2
461
356
24
3S6
201
184
111
194
401
2B3
3S1
20S
323
324
296
408
121
371
113
233
108
2B3
67
69
347
223
476
297
292
196
8
261
-------
VII-21
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
MET ABOLISH OF PESTICIDES: AH UPDATE
METABOLISM OF VOLATILE ANESTHETICS . . .
METAL TOXICITY III MAMMALS. VOL 1 « 2 ...
METHODOLOGY FOR ANALYTICAL TOX . . .
METHODS FOR ECOLOGICAL TOXICITY . . .
METHODS III TOXICOLOGY
METHODS USED III USSR FOR ...
MIDDLE MOLECULES M UREMIA . . .
MIDWEST RES. INST. LOADING FUNCTIONS . . .
MODEL ECOSYSTEM FOR THE EVALUATION
MODEL ECOSYSTEM STUDIES OF THE ...
MODELING NONPOINT POLLUTION FROM . . .
MODERN TRENDS 1* TOXICOLOGY, VOL 2
MOLECULAR BASIS OF BUL DE6RAOATIVE . . .
MOLECULAR BASIS OF ENVIRON. TOXICITY
NATIONAL OCCUPATIONAL HAZARD ... VOL II
NEPHROTOXIC MECHANISMS OF DRUGS . . .
NERVOUS SYSTEM TOXICOLOGY . . .
NEUROTOXIOTY OF THE VISUAL SYSTEM
NEUROTOXICOIOGY
NICKEL TOXICOLOGY
NITROGEN. PHOSPHORUS AND SULPHUR . . .
NON-AQUEOUS ELECTROLYTE HANDBOOK. VOL 1
NON-AQUEOUS ELECTROLYTE HANDBOOK, VOL II
NON-FLUORINATED PROPELLANTS AMD ...
NON-POINT SOURCE MODEL LOADING . . .
NON-POINT SOURCE MODEL MODELING NO! ...
NON-POINT SOURCE MODEL SIMULATION OF ...
NUTRITION AND THE BRAIN VOL. IV
NUTRITIONAL TOXICOLOGY VOL 1
NUTRITION STRESS AND TOXIC CHENS . . .
OPO CHEMICAL BUYERS DIRECTORY 69 ED
OCCUPATIONAL DISEASES: A GUIDE
OCCUPATIONAL EXPOSURE GUIDE
OCCUPATIONAL HEALTH GUIDELINES . . .
OCCUPATIONAL SAFETY It HEALTH REPORTER
OH THE EVALUATION OF THE ... (ARC
ORGAN DIRECTED TOXICITY. CHEMICAL . . .
ORGANIC CHEMICAL PROCESS ENCVCLO . . .
PARENT COMPOUND HANDBOOK
PAMKCHS TEXTBOOK OF MEDICAL . . .
PARTITION COEFFFICUNT AND BIOACCUMULATION
PARTITION COEFFICIENTS AND THEIR USES
PARTITION COEFFICIENTS TO MEASURE . . .
PATHOLOGY OF OXYGEN TOXICITY
PATTY'S INDUSTRIAL HYGIENE * TOXICOL 1
PATTY'S INDUSTRIAL HYGIENE * TOXICOL IIA
CHEMICAL
ACCESS
NO. CHEMICALS
*
*
*
~SI
0
*
*
*
~2B
*
*
*
*
*
-IOB
*
~2B
*
—1
*
210
310
B
*
*
*
*
*
*
14.744
*
*
*
*
-BOB
*
*
*
*
34
*
B
1
*
*
•
CE
3
X
X
X
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ENVIRONMENTAL EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
USE/DISPOSAL
u
u
u
u
u
u
u
X
u
u
u
u
u
i
Ul
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ECONOMICS
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUBLICATION TYPE
1
1
B
1
B
B
B
B
t
B
B
B
1
2
2
1
B
B
1
B
B
3
1
1
B
1
B
1
B
1
2
B
1
1
1
B
2
B
3
1
2
B
1
B
1
1
1
i
X
X
X
FREO. OF REVISION
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
3
B
B
B
1
B
B
B
4
B
B
B
B
B
B
B
>
Ul
g
SHELF
LOCATION
LC CALL NUMBER
[SK3S1.A2M N0.1B4)
[RD82.CS4J
RA1Z31.MB2LB2V
RA1221JI3B 1976"
OHB41.15TBBM47V
RA1221.M45V
[OR3S7.F72]
[RC915.S96 IBM]
[OPBOBP7BMH]
RA1191.MB4/
[RC91SJMN4S 19B2]
[RC347JM7]
[RE91.R63]
[RC34BJI4S]
[RA1Z31JM4I57]
[OH344JK7]
ODB60J3BV
[RA1270.SSA94]
[WLNUSS32.V.4.]
[RC622NK419SZ]
[RB1B1.V33]
TP12.06v/
RC9B4.N37
[KF3570.K4S]
TD56J.H3N5B4,/
[KF3S70A102!]
RC2SS.S7J.57
RAI19U9419BW
TP680 SS» I9BBV
QD2B1.RSP32/
RA1051.P34y
[RA124.09B34]
RC9B7.P37. 1978/
RC9B7.P37 \mS
AUTHOR
INDEX
CITATION NUMBER
2BB
104
25B
420
IBB
331
454
23S
279
29B
2B4
127
B6
52
BS
308
344
299
293
3BD
7B
421
21 S
21B
21
437
43B
439
4S3
190
448
322
310
229
2B1
29
209
74. 76
3B1
80
33S
94
243
319
39
97
99
-------
VII-22
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
PATTTS MDUSTMAl HYGIENE t TOXICOL II B
PATTY'S INDUSTRIAL HYGIENE Si TOXICOL DC
PATTYS INDUSTRIAL HYGIENE 1 TOXICOL HI
PERSPECTIVES IN TOXICOLOGY
PESTICIDE CHEMIST t MODERN TOXICOLOGY
PESTICIDE TRANSPORT AND RUNOFF . . .
PESTICIDES ABSTRACTS
PESTICIDES IN THE ENVIRONMENT. VOL 1 PT 1
PESTICIDES IN THE ENVIRONMENT. VOL II
PESTICIDES IN THE ENVIRONMENT. VOL III
PHARMACOLOGICAL METHODS IN TOXICOLOGY
PHYSICAL AND THERMODYNAMIC PROPERTIES
A PHYSICAL CONCEPT OF SOIL-WATER . . .
PHYSICAL PROPERTIES OF CHEMICAL 1. II, M ...
PHYSICAL PROPERTIES OF MOLECULAR . . .
PHYSICIANS' DESK REFERENCE . . .
PHYSICS AND CHEMISTRY OF ORGANIC . . .
PHYSUCHEMICAl PROPERTIES OF SOME . . .
POISONING: DIAGNOSIS AND TREATMENT
POISONING: DIAGNOSIS AND TREATMENT
POISONS — ANTIDOTES AND ANECDOTES
POLLUTION DETECTION AND MONITORING . . .
POLYNUCUAR AROMATIC HYDROCARBON . . .
POTENTIAL IND. CARCINOGENS * MUTA. VOL 4
PREDICTING BIOLOGICAL EFFECTS AS A ...
PREDICTING PESTICIDE RUNOFF FROM . . .
PREDICTION OF BIOCONCENTRATION . . .
PREDICTION OF CHRONIC TOXIOTV . . .
PREDICTIVE TOXICOMETRICS
PREUMNURY ASSESSMENT OF SUSP . . .
PRINCIPLES AND METHOD OF TOXICOLOGY
PRINCIPLES AND PROCEDURES FOR EVAL . . .
PRINCIPLES OF BIOCHEMICAL TOXICOLOGY
PRINCIPLES OF GENETIC TOXICOLOGY
A PRIORI PREDICTIVE METHODS OF ...
PRIORITY TOXIC POLLUTANTS: HEALTH . . .
PROC. OF THE 1ST INTER. CONG. ON TOXICOL.
PROC. INHALATION. TOXICOL Si TECHNOLOGY SYM.
PROC. OF THE INT'L COURSE ON THE ...
PROGRAM AND ABSTRACTS SYMP. ON ...
PROGRESS IN CHEMICAL TOXICOLOGY. S VOLS.
PROGRESS IN TOXICOLOGY. VOL 1
PROGRESS IN TOXICOLOGY. VOL U
PROTECTION OF ENVIRONMENT .40CFR 1.1. VOL. 40
PROTEIN DEFICIENCY AND PESTICIDE . . .
THE PROPERTIES OF GASES I LIQUIDS . . .
PULMONARY TOXICOLOGY OF RESPtRABlE . . .
QUALITY CONTROL IN TOXICOLOGY
QUANTITATIVE TOXICOLOGY
CHEMICAL
ACCESS
NO. CHEMICALS
*
*
*
*
*
*
*
*
*
*
*
722
-20
-1,401
*
*
*
1
-7.100
*
*
*
*
>17B
25
IB
*
*
253
*
*
*
B
129
*
*
*
*
*
-5
0
*
-20
*
*
0
*
i
X
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ENVIRONMENTAL EFFECTS
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
j{
U
U
X
U
U
U
U
U
U
U
U
U
U
EXPOSURE
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ECONOMICS
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUBLICATION TYPE
1
1
1
1
1
B
B
B
B
B
3
2
B
1
I
1
1
1
1
1
1
B
B
1
1
B
B
B
1
2
1
1
2
1
B
3
B
B
1
B
1
1
1
6
1
1
B
t
2
i
S
X
X
X
FREtt. OF REVISION
B
B
B
B
1
B
B
B
B
B
B
B
B
B
B
3
B
B
B
B
B
B
B
B
B
B
B
B
2
B
B
B
B
B
B
B
B
B
B
B
B
B
B
3
B
B
B
B
B
111
>
Ul
i
X
SHELF
LOCATION
LC CALL NUMBER
RC9B7W7 UTS/
RC9*7J>37 1971>/
RCBB7.P37 187S/
TP2UJ>47 P4BV
SS951.W2*
SB9S1.VW2-
SBHI.W12'
RA123I.P45-
003D&A4.W3S./
QD473.D73y
[0047BM2]
RS7BJ>S
-------
VII-23
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
aiNCK REFERENCE TO CUMCM. TOXICOLOGY
RADIOLOGY IN CLINICAL TOXICOLOGY
A RAPID METHOD FOR ESTIMATING LOG , . . .
REGISTRY OF TOXIC EFFECTS OF CHEMICAL . . .
REPRODUCTIVE HAZARDS OF INDUSTRIAL . . .
RESEARCH PROGRAM OH HAZARD . . .
REVIEW OF THE ENVIRONMENTAL FATE . . .
REVIEWS IN BIOCHEMICAL ... VOL 1
REVIEWS IN BIOCHEMICAL ... VOL II
REVIEWS II BIOCHEMICAL . . .VOL Ul
REVIEWS III BIOCHEMICAL . . .VOL IV
ROOD'S CHEMISTRY OF CARBON CMPOS.
THE ROLE OF TERRESTRIAL AND AQUATIC . . .
SAFETY EVALUATION OF CHEMICALS IN FOOD . . .
SCIENTIFIC CONSIDERATIONS IN MONITORING . . .
SECOND TOP H CHEMICAL COMPANIES . . .
SELECTED CONSTANTS: OXIDATION-REDUCTION . . .
SELECTED VALUES OF CHEMICAL THERMODYNAMC . . .
SELECTIVE TOXICITY AND RELATED TOPICS . . .
SELECTIVE TOXIOTY. THE PHYSICO-CHEMICAL . . . 5TH EO.
SELECTIVE TOXICmf. THE PHYSICO-CHEMICAL . . . ITH ED.
SIMULATION OF NUTRIENT LOADINGS IN ...
SOLID WASTES: ORIGIN. COLLECTION. . . .
SOLUBILITIES OF INORGANIC AND METAL-ORGANIC ... VOL 1
SOLUBILITIES OF INORGANIC AND METAL ... VOL II
SOLUBILITIES OF INORGANIC AND ORGANIC . . .
SORPTION OF HYOROPHOBIC POLLUTANTS ON ...
SPECIES-SPECIFIC POTENTIAL OF INVERT . . .
SPECIFICATIONS FOR THE IDENTITY AND PURITY . . .
STANDARD OPERATING PROCEDURES IN ...
STANDARD OPERATING PROCEDURES IN VITRO . . .
STORAGE AND DISPOSAL OF DANGEROUS . . .
STRUCTURE-ACTIVITY CORRELATIONS . . .
STRUCTURE.ACTWITY RELATIONSHIPS . . .
A STUDY OF HAZARDOUS WASTE MATERIALS ... VOL 1
A STUDY OF HAZARDOUS WASTE MATERIALS ... VOL. 2
A STUDY OF HAZARDOUS WASTE MATERIALS ... VOL. 3
A STUDY OF INDUSTRIAL DATA ON CANDIDATE . . .
SURFACTANT BIOOEGRADATION
SURVEY ANALYSIS AND SUPPLEMENTAL . . .
SURVEY MANUAL
SURVEY OF COMPOUNDS WHICH HAVE . . .
SURVEY OF CONTEMPORARY TOXICOLOGY . . .
SURVEY OF CONTEMPORARY TOXICOLOGY . . .
SYMPOSIUM ON IMPACT OF TOXICOLOGY ON ...
SYMPOSIUM ON TOXICOLOGY AND NUTRITION . . .
SYNTHETIC ORGANIC CHEMICALS: . . .
SYNTHETIC ORGANIC CHEMICALS
CHEMICAL
ACCESS
M
5
I
U
S
*
*
-SB
issjHs
48
M
74
*
*
*
*
*
*
31
B
0
~35B
*
*
*
*
«
~1BB
-100
*
10
*
-210
*
*
*
*
14
-400
13
12
117
*
7,000
~1,20B
-28.0W
*
*
*
*
*
*
•
ae
u
X
X
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
ENVIRONMENTAL EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
X
X
X
X
X
i
u
u
u
u
u
D
D
X
X
X
u
u
u
EXPOSURE
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
,
X
X
X
X
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUILICATION TYPE
1
1
6
1
1
6
1
1
I
1
1
3
2
1
1
1
1
1
6
1
1
1
1
1
1
1
C
1
2
1
1
B
1
>
1
B
I
1
1
1
1
1
1
1
6
6
1
1
e
i
X
X
X
X
FREQ. OF REVISION
B
B
2
3
B
1
3
3
1
3
B
1
B
B
3
B
1
B
1
i
B
B
1
1
1
B
B
1
B
1
2
1
B
6
B
B
B
B
B
1
B
1
B
B
g
3
ON LINE VERSION
X
X
SHELF
LOCATION
LC CALL NUMBER
[RA121 1.063]
[RAI223JI33AB7]
RA1221.U6CV
PB 2B3 1BZ*
[BKS RA1221.HB)
QD281.RI2-
[OKS11 J7A36 N0.17]
Z7S91JS7V47V
RA1 199.834^
ISSNMOB-2347
[OOB3JIBCS3]
ODISSJ.USISv'
RM2B2JU1I73'
RM2S2.AS 1173'
[RM262A6 1879)
BKS TDI97.M31-
ODBB.U*
OOBB.LC
[00643 JI72 19131
[RA11S9.5.IS7M4]
BKS RA119S.57"
IS8ND-8391-4124-I
TD370.V3-
TD370.V3,/
tTPSM]
TP9S459S-
[RC282.H33]
RA1211.S93V
RA1211.SS3,/
[RA1270.FSH7J
[OP141.A1W68]
[H09999.D9U6]
[HD98SS.D9U5]
AUTHOR
INDEX
ec
!
187
14
44B
313
43
341
73
197
IBB
IB*
200
103
12
462
in
414
91
4BB
4
B
B
12B
2BB
24B
2SO
404
222
220
147
334
423
463
447
44B
80
81
82
388
422
309
307
303
431
16
22
430
441
442
-------
VII-24
OTS INFORMATION RESOURCES MATRIX HANDBOOKS/PRINTED SOURCES
TITLE OF PRINTED
SOURCE
TLVS THRESHOLD LIMIT VALUES FOR ...
THERMOCHEMISTRY OF ORGANIC ANO . . .
THERMODVMMIC PROPERTIES OF ...
TIERED TESTING FOR CHEMICAL HAZARD . . .
TOXIC AND HAZARDOUS INDUSTRUL CHEM . . .
TOXIC METALS AND POLLUTION CONTROL . . .
TOXH3TY AND METABOLISM OF INDUSTRIAL . . .
TOXIOTY AND SIDE EFFECTS OF PSYCHOTROPIC . . .
TOXIOTY OF 434* CHEMICALS TO LARVAL. . .
Toxicmr OF CHEMICALS AND PULPING . . .
TOXICTTY OF HEAVY METALS . . . PT. 1
TOXIOTY OF HEAVY METALS . . . PT. 2
TOXIOTY OF INDUSTRIAL METALS
TOXIOTY OF PLUTONIUM, AMERICIUM . . .
TOXIOTY OF PURE FOODS
TOXICOL06IC EMERGENCIES
TOXICOLOGICAL AND PATHOLOGICAL STUDIES . . .
TOXICOLOGICAl ASPECTS OF FOOD . . .
TOXICOLOGICAL EFFECTS OF EMISSIONS . . .
TOXICOLOGICAL EVALUATION OF PARATHION
TOXICOLOGY: MECHANISMS ... VOL 1
TOXICOLOGY: MECHANISMS ... VOL 2
TOXICOLOGY AND BIOCHEMISTRY OF ...
TOXICOLOGY AND OCCUPATIONAL MEDICINE . . .
TOXICOLOGY AND POISON PREVENTION
TOXICOLOGY, BIOOEGRADATION AND EFFICACY . .
TOXICOLOGY IN THE TROPICS
TOXICOLOGY OF DRUGS ANO CHEMICALS
TOXICOLOGY OF HALOGENATED HYDROCARBONS . . .
TOXICOLOGY OF THE EYE
TOXICOLOGY: PRINCIPLES AND PRACTICE, VOL 1
TOXICOLOGY: REVIEW AND PROSPECT
TOXICOLOGY: THE BASK SCIENCE OF POISONS
TOXINS OF ANIMAL ANO PUNT ORIGIN
TRANSFER OF RADIOACTIVE MATERIALS . . .
TREATISE ON POISONS IN RELATION . . .
TREATMENT AND DISPOSAL OF WASTES
TREATMENT OF COMMON ACUTE POISONHG
US. EXPORTS SCHEDULE ft COMMODITY. . .
USE OF STRUCTURE-REACTIVITY . . .
WATER QUALITY CRITERIA. 2ND ED. ...
WATER QUALITY CRITERM
WATER QUALITY CRITERM DATA BOOK. VOL. 1 A 2
WATER-RELATED ENVIRONMENTAL FATE OF ...
WATER-SOLUBLE POLYMERS: DEVELOPMENTS . . .
WORKSHOP ON CELLULAR AND MOLECULAR . . .
CHEMICAL
ACCESS
NO. CHEMICALS
-SOU
*
*
0
702
IS
I3S
*
4341
*
-25
-50
46
3
*
*
*
*
*
-40
*
*
*
*
*
-2SB
*
*
*
-1.600
*
*
*
*
-30
-100
0
+
*
-30
*
*
-75
-270
-105
*
*
K
U
OTS DATA CATEGORIES
SUBSTANCE IDENTIFICATION
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X
X
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X
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X
X
X
X
X
X
X
X
X
X
X
PHYSICAL-CHEMICAL
PROPERTIES
X
X
X
X
X
X
X
X
,
X
X
X
X
X
X
X
X
HEALTH EFFECTS
X
X
X
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X
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X
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X
X
X
X
X
X
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X
X
X
X
X
X
X
X
X
X
X
X
X
X
ENVIRONMENTAL EFFECTS
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
PRODUCTION/PROCESSING
X
X
X
X
X
X
X
USE/DISPOSAL
U
X
X
U
U
U
U
U
U
U
U
U
U
U
U
U
g
X
IU
X
X
X
X
X
X
X
X
X
X
X
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X
X
X
X
X
X
X
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X
X
X
X
X
X
ECONOMICS
X
X
X
REGULATIONS/CONTROL
X
X
X
X
X
X
X
PUBLICATION
INFORMATION
PUBLICATION TYPE
1
1
1
*
1
1
1
*
1
1
1
s
1
2
1
1
2
I
2
2
t
1
2
1
1
s
1
1
6
1
1
6
1
1
2
1
1
1
1
8
1
1
1
1
6
SUPPLEMENTS
X
X
X
FREO. OF REVISION
3
1
s
1
1
1
*
*
1
s
s
1
*
1
*
*
s
s
s
1
B
6
1
*
1
1
*
s
1
1
B
B
B
B
B
B
B
B
3
B
B
B
B
B
B
B
ONLINE VERSION
SHELF
LOCATION
LC CALL NUMBER
[RC9U.3AS4]
QDS11.C8B'
OD50IJ37
ISSNMI3-B3BX
T55.3H3B6'
TDBM.M45SSI./
RA127aS*B72y
[RA1I90.EI]
[SHI77WB4LBB)
RA1231.MS2TSS/
RA1231.MB2T89V
[RA1231.M62B7]
[RA1231J1S5N4S]
[RA125B.B6S]
[RAI2I9.TBS1
[RA122J.G67]
RAIISOJB
[RA677.D63 053]
RA1121.S73-
RA 121 1473*
RA1 235.64*
RA1191J57y
[RAI2II.TB34]
TP994i§6-
[RA 1211. 042]
[RAI242.H35T89]
RE4I.GI»y
RA1211.T637-
[RAII90.EB]
RA1211.C296^
[QP941J4t]
TX571.G37,/
[RA1211.C66]
[RAB.A2S]
[RAI2IB.M3B]
(TD3SO.W3B]
[TD370.W3S4]
DOC ELB002B45*
QD382.W31443/
[RAI19I.WBB]
AUTHOR
INDEX
CITATION NUMBER
z
IDS
214
207
3B4
210
77
35
IB
2S4
32B
7B
325
32B
65
174
17B
244
24B
I2S
411
412
172
123
4*1
231
391
122
232
181
355
136
SS
120
164
9B
455
276
432
479
2B1
315
19
83
2S6
IN
-------
VII-25
Citation HANDBOOK/PRINTED SOURCES
Number AUTHOR INDEX
1. ACGIH. 1980. American Conference of Governmental Industrial
Hygienists. Documentation of the threshold limit values. 4th ed.
Cincinnati, OH: ACGIH.
2. ACGIH. 1982. American Conference of Governmental Industrial
Hygienists. TLVs threshold limit values for chemical substances and
physical agents in the work environment with intended changes for
1982. Cincinnati, OH: ACGIH.
3. ACS. 1982. American Chemical Society. Chemcyclopedia. Washington,
DC: ACS.
4. Albert A. 1968. Selective toxicity and related topics, 4th ed.
London: Methuen.
5. Albert A. 1973. Selective toxicity. The physico-chemical basis of
therapy, 5th ed. London: Chapman and Hall.
6. Albert A. 1979. Selective toxicity: the physico-chemical basis of
therapy, 6th ed. Chapman and Hall, London.
7. Aldrich Chemical Co. 1982-1983. Aldrich catalog/handbook of fine
chemicals. Milwaukee, WI: Aldrich.
8. Altman PL, Dittmer DS, eds. 1968. Metabolism. Bethesda, MD:
Federation of American societies for experimental biology handbooks.
9. American Chemical Society. 1934-present. Chemical Abstracts
Service. Chemical abstracts, Columbus, OH: ACS.
10. Ames BN. 1979. The detection and hazards of environmental
carcinogens/mutagens. In: Monitoring toxic substances ACS symposium
series # 94. Washington , DC: ACS.
11. Anderson HJ, Baker MJ, Gandenberger EL et al., eds. 1983. Chem
Sources. USA. Ormond Beach, FLA: Directories Publishing Company.
12. Anderson JM, Macfadyen A, eds. 1976. The role of terrestrial and
aquatic organisms in the decomposition processes. Proceedings from
the 17th Symposium of the British Ecological Society. Oxford:
Blackwell Scientific Publication.
13. Andreyshcheva NG. 1976. Predicting biological effect as a function
of the chemical structure and the primary physical and chemical
properties of organic compounds. Environ Health Perspect 13:27-30.
14. Ansell G. 1974. Radiology in clinical toxicology. London:
Butterworth.
-------
VII-26
15. Anthony T, ed. 1980. Survey of contemporary toxicology. Vol. 1.
New York: Wiley.
16. Applegate VC, Howell JH, Hall AE, Smith MA. 1957. Toxicity of
4,346 chemicals to larval lampreys and fishes. Special Scientific
Report - Fisheries No. 207. Washington, DC: US Fish and Wildlife
Service, Dept. of the Interior.
17. Armstrong GT, Goldherg RN. 1976. An annotated bibliography of
compiled thermodynamic data sources for biochemical and aqueous
systems (1930-1975). Equilibrium, enthalpy, heat capacity, and
entropy data. National Bureau of Standards, U.S. Dept. of Commerce.
18. Arthur D. Little Inc. 1970. Water quality criteria data book, Vol.
1: Organic chemical pollution of freshwater. Washington, DC: Water
Quality Office, U.S. EPA. Contract 14-12-538.
19. Arthur D. Little, Inc. 1971. Water quality criteria data book, Vol.
II: Inorganic chemical pollution of freshwater. Washington, DC:
Water Quality Office, U.S. EPA. Contract # 14-12-538.
20. Arthur D. Little, Inc. 1975. Economic analysis of effluent
guidelines-organic chemicals industry (major products). Washington,
DC: Office of Planning and Evaluation, U.S. EPA. EPA-230/2-75-019.
Contract 68-01-1541.
21. Aviado DM, Zakhari S, Watanabe T. 1977. Non-fluorinated propellants
and solvents for aerosols. Cleveland, OH: CRC.
22. Ayres JC, Kirschman JC, eds. 1981. Symposium on impact of
toxicology on food processing, June 6-7, 1980. Sponsers: Institute
of Food Technologists and International Union of Food Science and
Technology. Westport, CN: AVI.
23. SNA. 1978-1983. The Bureau of National Affairs. Chemical
regulation reporter. Hazardous materials transportation.
Washington, DC: BNA.
24. BNA. 1981. Bureau of National Affairs, Inc. International
environment reporter. Washington, DC: BNA.
25. BNA. 1981, 1982. The Bureau of National Affairs. Chemical
regulation reporter reference file. Washington, DC: BNA.
26. BNA. 1982. Bureau of National Affairs, Inc. Environment reporter.
Washington, DC: BNA.
27. BNA. 1982, 1983. The Bureau of National Affairs. Chemical
regulation reporter. Index to government regulation. Washington,
DC: BNA.
-------
VII-27
28. BNA. 1983. The Bureau of National Affairs. Chemical regulation
reporter. Current reports. Washington, DC: BNA.
29. BNA. 1983. Bureau of National Affairs, Inc. Occupational safety
and health reporter. Washington, DC: BNA.
30. Bailar JC, Emeleus HJ, Nyholm R, et al, eds. 1973. Comprehensive
inorganic chemistry, Vols. 1-5. New York: Pergamon.
31. Bailey GW, Swank RRH, Nicholson HP. 1974. Predicting pesticide
runoff from agricultural land: A conceptual model. J Environ Qual
3(2):95-102.
32. Baker CE. 1982. Physicians' desk reference, 36th ed. Oradell, NJ:
Medical Economics Company, Inc.
33. Baker RA, ed. 1980. Contaminants and sediments, Vol. 1. Fate and
transport case studies, modeling, toxicity. Ann Arbor, MI: Ann
Arbor Science.
34. Baker RA, ed. 1980. Contaminants and sediments, Vol. 2. Analysis,
chemistry, biology. Ann Arbor, MI: Ann Arbor Science.
35. Baker SBD, Boissier JR, Koll W, eds. 1968. Toxicity and
side-effects of psychotrophic drugs. Proceedings of the European
Society for the Study of Drug Toxicity, Vol. IX, Paris, Feb. 1967.
Amsterdam: Excerpta Medica.
36. Balazs T, ed. 1981. Cardiac toxicology, Vol I. Boca Raton, FL:
CRC.
37. Balazs T, ed. 1981. Cardiac toxicology. Vol. II. Boca Raton,
FL: CRC.
38. Balazs R, ed. 1981. Cardiac toxicology, Vol. III. Boca Raton, FL:
CRC.
39. Balentine JD. 1982. Pathology of oxygen toxicity. New York:
Academic.
40. Ballantyne B, ed. 1974. Forensic toxicology. Bristol: Wright.
41. Ballantyne B, ed. 1977. Current approaches in toxicology.
Bristol: Wright.
42. Bandal SK, Marco GJ, Goldberg L, Leng ML, eds. 1981. The pesticide
chemist and modern toxicology. Washington, DC: ACS.
43. Barlow SM, Sullivan FM, eds. 1982. Reproductive hazards of
industrial chemicals: An evaluation of animal and human data.
London: Academic.
-------
VII-28
44. Barton D, Ollis WD, eds. 1979. Comprehensive organic chemistry,
Vols 1-6. New York: Pergamon.
45. Bartosek I, Guaitani A, Pacei E, eds. 1982. Animals in
toxicological research, 1st ed. Monographs of the Mario Negri
Institute for Pharmacological Research, Milan. New York: Raven.
46. Baselt RC. 1978. Disposition of toxic drugs and chemicals in man,
Vol. I. Centrally acting drugs. Davis, CA: Biomedical
47. Baselt RC. 1978. Disposition of toxic drugs and chemicals in man.
Vol. II. Peripherally-acting drugs and common toxic chemicals.
Davis, CA: Biomedical.
48. Baselt RC. 1982. Disposition of toxic drugs and chemicals in man,
2nd ed. Davis,CA: Biomedical.
49. Beilstein Institute for Literature of Organic Chemistry. 1975.
Beilsteins's handbook of organic chemistry and supplementary series
I, II, III and IV. The literature to 1959 inclusive: Formula index
for volumes l-( ). 4th ed. New York: Springer-Verlag
50. Beilstein Institute for Literature of Organic Chemistry. 1975.
Beilsteins's handbook of organic chemistry and supplementary series
I, II, III and IV. The literature to 1959 inclusive: Subject index
for volumes l-( ). 4th ed. New York: Springer-Verlag
51. Bennett H, ed. 1974. Concise chemical and technical dictionary, 3rd
ed. New York: Chemical Publishing Co.
52. Berlin RO, Herrmann H, Lepow IH, Tanzer JM, eds. 1978. Molecular
basis of biological degradative processes. New York: Academic.
53. Bernheimer AW, ed. 1977. Perspectives in toxicology. New York:
Wiley.
54. Beynon LR, Cowell EB, eds. 1974. Ecological aspects of toxicity
testing of oils and dispersants. Proceedings of a workshop on the
toxicity of oils and dispersants held at the Institute of Petroleum,
London. New York: Wiley.
55. Bhatnager RS, ed. 1980. Molecular basis of environmental toxicity.
Ann Arbor, MI: Ann Arbor Science.
56. Bioscience Information Service of Biological Abstracts.
1927-present. Biological abstracts. Philadelphia, PA: Bioscience
Information Service of Biological Abstracts.
57. Blood FR, ed. 1969. Essays in toxicology, Vol. 1. New York:
Academic.
-------
VI I-29
58. Bond RG, Straub CP, Prober R. 1972-1975. Handbook of environmental
control, 1st ed. 5 vols. Cleveland, OH: CRC.
59. Bond! A. 1968. Physical properties of molecular crystals, liquids,
and glasses. New York: Wiley.
60. Booz Allen Applied Research, Inc. 1973. A study of hazardous waste
materials, hazardous effects and disposal methods, Vol. I.
Washington, DC: Office of Research and Development, U.S. EPA.
EPA-670/2-73-14. PB 221 465.
61. Booz Allen Applied Research, Inc. 1973. A study of hazardous waste
materials, hazardous effects and disposal methods, Vol. II.
Washington, DC: Office of Research and Development, U.S. EPA.
EPA-670/2-73-15. PB 221 466.
62. Booz Allen Applied Research, Inc. 1973. A study of hazardous waste
materials, hazardous effects and disposal methods, Vol III.
Washington, DC: Office of Research and Development, U.S. EPA.
EPA-670/-2-73-16. PB 221-467.
63. Boyd EM. 1972. Predictive toxicometrics. Bristol, England:
Scientechnica.
64. Boyd EM. 1972. Protein deficiency and pesticide toxicity.
Springfield, IL: Charles C Thomas.
65. Boyd EM, Boyd CE. 1973. Toxicity of pure foods: Cleveland, OH:
CRC.
66. Boyland E, Goulding R, eds . 1968. Modern trends in toxicology, Vol,
2. London: Butterworths.
67. Brady GS, Clauser HR. 1977. Materials handbook. An encyclopedia
for managers, technical professionals, purchasing and production
managers, technicians, supervisors, and foreman. New York: McGraw -
Hill.
68. Brakhnova IT. 1975. Environmental hazards of metals. Toxicity of
powdered metals and metal compounds. New York: Plenum.
69. Branson DR, Dickson KL, eds. 1981. Aquatic toxicology and hazard
assessment: Proceedings of the Fourth Annual Symposium on Aquatic
Toxicology. Sponser: ASTM, Am. Soc. for Testing and Materials,
Philadelphia, PA.
70. Bretherick L. 1979. Handbook of reactive chemical hazards, 2nd ed.
Boston, MA: Butterworths.
71. Brooks GT. 1975. Chlorinated insecticides, Vol. II. Biological
and environmental aspects. Cleveland, OH: CRC.
-------
VII-30
72. Brown VK. 1980. Acute toxicity in theory and practice: With
special reference to the toxicology of pesticides. New York: Wiley.
73. Brown SL, Chan FY, Jones JL, et al. 1975. Research program on
hazard priority ranking of manufactured chemicals. Phase II - Final
report. Washington, DC: Research Applied to National Needs (RANN),
National Science Foundation. NTIS PB-263-161
74. Brown SS, Davies DS, eds. 1981. Organ directed toxicity. Chemical
indices and mechanisms. Proceedings of the Symposium on Chemical
Indices and Mechanisms of Organ-directed Toxicity. Barcelona, Spain,
March 4-7, 1981. International union of pure and applied chemistry
symposium series. Oxford: Pergamon.
75. Brown SS, Davies DS, eds. 1981. Organ-directed toxicity: Chemical
indices and mechanisms. Proceedings of the Symposium on Chemical
Indices and Mechanisms of Organ Directed Toxicity. Oxford: Pergamon.
76. Brown SS, Sunderman FW, eds. 1980. Nickel toxicology. Proceedings
of the Second International Conference on Nickel Toxicology, Swansea,
Wales, Sept. 3-5, 1980. New York: Academic.
77. Browning E. 1965. Toxicity and metabolism of industrial solvents.
New York: Elsevier.
78. Browning E. 1969. Toxicity of industrial metals, 2nd ed. London:
Butterworth.
79. Bruce DL. 1980. The functional toxicity of anesthesia. New York:
Grune and Stratton.
80. Brusick DJ. 1980. Principles of genetic toxicology. New York:
Plenum.
81. Buonicore A, Theodore L. 1975. Industrial control equipment for
gaseous pollutants, Vol I. Cleveland, OH: CRC.
82. CAS. 1981. Chemical Abstracts Services. Parent-compounds
handbook. Columbus, OH: ACS.
83. Callahan M, Slimak M, Gabel N. 1979. Water-related environmental
fate of 129 priority pollutants, Vols. I and II, final report.
Washington, DC: Office of Water Planning and Standards, U.S. EPA.
Contract C8-01-3852.
84. Carrin M. 1978. Atmospheric chemistry modelling. J Chem Ed
55(4):210-215.
85. Casarett LJ, Doull J, eds. 1975. Toxicology: The basic science of
poisons. New York: Macmillan.
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VII-31
86. Chakrabarty AM, ed. 1982. Biodegradation and detoxification of
environmental pollutants. Boca Raton, FL: CRC.
87. Chambers JE, Yarbrough JD, eds . 1982. Effects of chronic exposures
to pesticides on animal systems. New York: Raven.
88. Chambers PL, Chambers CM, eds. 1981. A critique of accepted
requirements and methodology. Arch Toxicol Supplements, Vol 5:1-382.
89. Chambers PL, Gunzel P, ed. 1979. Mechanism of toxic action on some
target organs. Proceedings of the European Society of Toxicology.
Berlin: Springer-Verlag.
90. Chambers PL, Klinger W. eds. 1980. Further studies in the
assessment of toxic actions. Proceedings of the European Society of
Toxicology, Dresden, June 11-13, 1979. Arch Toxicol Supplement 4.
p. 1-507.
91. Chariot G, Collumeau A, Marchon JC. 1971. Selected constants:
Oxidation reduction potentials of inorganic substances in aqueous
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92. Chemical Sources Europe. 1974. 2nd ed. Flemington, NJ: Chemical
Sources Europe.
93. Chiou CT, Freed VH. 1977. Chemical studies on bench mark industrial
chemicals (annual report). Washington, DC: Research Applied to
National Needs (RANN), Natl. Science Foundation. NTIS PB 274-263.
94. Chiou CT, Freed VH, Schmedding DW, Kohnert RL. 1977. Partition
coefficient and bioaccumulation of selected organic chemicals.
Environ Sci Technol ll(5):475-78.
95. Chiou CT, Peters LJ, Freed VH. 1979. A physical concept of
soil-water equilibria for nonionic organic compounds. Science
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96. Christison R. 1973. A treatise on posions in relation to medical
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97. Clayton GD, Clayton FE, eds. 1978. Patty's industrial hygiene and
toxicology, 3rd ed., Vol. 1. General Principles. New York: Wiley.
98. Clayton GD, Clayton FE, eds. 1981. Patty's industrial hygiene and
toxicology, 3rd ed., Vol. 2A. Toxicology. New York: Wiley.
99. Clayton GD, Clayton FE, eds. 1981. Patty's industrial hygiene and
toxicology, 3rd ed., Vol. 2B. Toxicology. New York: Wiley.
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VII-32
100. Clayton GD, Clayton FE, eds . 1982. Patty's industrial hygiene and
toxicology, 3rd ed., Vol. 2C. Toxicology. New York: Wiley.
101. Clement Assoc., Inc. 1981. Chemical hazards to human reproduction.
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102. Codd LW, Dijkhoff K, Fearon JH, Van Oss CJ, Roebersen HG, Stanford
EG, eds. 1972. Chemical technology: An encyclopedic treatment,
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103. Coffey S. 1964. Rodd's chemistry of carbon compounds, 2nd ed.
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104. Cohen EN, VanDyke RA. 1977. Metabolism of volatile anesthetics:
Implications for toxicity. Reading, MA: Addison-Wesley.
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111. Cravey RH, Baselt RC. 1981. Introduction to forensic toxicology.
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VII-33
115. Davidson RL, ed. 1980. Handbook of water-soluble gums and resins.
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116. De Bruin A. 1976. Biochemical toxicology of environmental agents.
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117. DeCastro FJ, Jaeger RW. 1978. Clinical toxicology manual. St
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123. Deichmann WB, ed. 1979. Toxicology and occupational medicine.
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VII-34
129. Dortland RJ. 1980. lexicological evaluation of parathion and
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VII-35
143. Elliott HW, George R, Okun R, eds. 1976. Annual review of
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VII-60
Glossary of Abbreviations
ACS:
AD:
ADCR:
AEROS:
AGRICOLA:
AIS:
APILIT:
APIPAT:
APTIC:
AQUATOX:
AQUIRE:
ARM:
ASFA:
ASI:
ASTM:
ATM:
BBIP:
BEHAVIORTOX:
BETS:
BHRA FLUID ENGINEERING:
BIOL:
BIOSIS:
BMDPS:
EPS:
BRS:
CA-CON:
CA SEARCH:
CAB ABSTRACTS:
CAB:
CANCERLIT:
American Chemical Society
Assessment Division
Automated Document Control Register System
Aerometric and Emission Reporting System
Agricultural Online Access
Section 8(a) Asbestos Information System
Index to American Petroleum Institute Abstracts
of Refining Literature
Index to American Petroleum Institute Patents
Air Pollution Technical Information Center
Columbia National Fisheries Research Laboratory
Data
Aquatic Toxicity Data File
Agricultural Runoff Model-Version II
Aquatic Sciences and Fisheries Abstracts
American Statistical Index
American Society for Testing and Materials
Atmospheric Transport Model
BRS-Books in Print
Behavioral Effects Data File
Basic Extramural Tracking System
British Hydromechanics Research Association
Bilogical Sciences Information Service
Biological Sciences Information Service
Bio-Medical Statistical Package
Budget Planning System
Bibliographic Retrieval Services
Chemical Abstracts Condensates
Chemical Abstracts Service Search
Commonwealth Agricultural Bureaux Abstracts
Commonwealth Agricultural Bureaux Abstracts
Cancer Literature Information Online
-------
VII-61
CANCERPROJ:
CAS:
CBI:
CBDS:
CCAS:
CCD:
CCS:
GDI:
CEB:
CECATS:
CEER:
CFB:
CFR:
CHEM:
CHEMABS:
CHEMDEX:
CHEMFATE:
CHEMLAB:
CHEMLINE:
CHEMNAME:
CHEMSEARCH:
CHEMSIS:
CHIB:
CHIP:
CHRIS:
CICIS:
GIN:
CIDS:
CIRB:
CIS:
CLAIMS/CLASS:
Cancer Literature of Ongoing Research Projects
Chemical Abstracts Services
Confidential Business Information
Carcinogenesis Bioassay Data Systems
Central Chemical Assessment File
Chemical Control Division
Chemical Collection System
Comprehensive Dissertation Index
Chemical Engineering Branch
CHIB Existing Chemical Tracking System
Consumer and Environmental Exposure Report
Chemical Fate Branch
Code of Federal Regulations
Chemical Abstracts Service Search
Chemical Abstracts Service Search
Chemical Index Database
Environmental Fate Database
Chemical Modeling Laboratories
Chemical Dictionary Online
Chemical Abstracts Chemical Name Dictionary
Chemical Dictionary for Singly Indexed
Substances
Chemical Hazard Identification Branch
Chemical Hazard Information Profile
Chemical Hazard Response Information System
Chemicals in Commerce Information System
Chemical Industry Notes
Chemical Information and Data System (U.S. Army)
Chemical Information Reporting Branch
Chemical Information System
Index to U.S. Patent Office's Classification
Codes
-------
VII-62
CLEAR:
CLOGP:
COMPENDEX:
CPSC:
CRB:
CRC:
CREB:
CRGS:
CRIS/USDA:
CSIN:
CSR/TSR:
CTCP:
D&B:
DARC:
DDE:
DOS:
DMI:
DOE:
DOE-EDB:
DOT:
DTS:
DWRC:
Dermal:
EAB:
EB:
EDNOHS:
EDS:
EEB:
EED:
EIS:
EMIC:
ENDEX:
EN PART:
EPA Data Base and Environmental Model Index
A Program for Estimating log P
Computerized Engineering Index
Consumer Product Safety Commission
Chemical Regulation Branch
The Chemical Rubber Company
Chemical Review and Evaluation Branch
Chemical Regulations and Guidelines System
Current Research Information System
Chemical Substances Information Network
Chemical Status Report or TSCA Status Report
Clinical Toxicology of Commercial Products
Dun & Bradstreet
Description Acquisition Recovery and Design
Design and Development Branch
Data Dictionary System
Dun's Market Identifiers
Department of Energy
Department of Energy - Energy Data Base
Department of Transportation
Document Tracking System
Denver Wildlife Research Center
OTS Dermal Absorption Database
Exposure Assessment Branch
Epidemiology Branch
Exposure Dictionary for National Occupational
Hazards Survey
Environmental Data Index - NOAA
Environmental Effects Branch
Exposure Evaluation Division
Economic Information Systems
Environmental Mutagen Information Center
Environmental Data Index - NOAA
Environmental Partitioning Model
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VII-63
ENVIROLINE:
EPA:
EPACASR:
ERL:
ETD:
ETIC:
EXAMS:
EMBASE:
FAO:
FDA:
FEDREG:
FIND/SVP:
FISH REPRODUCTIVE:
FLUIDEX:
FMIS:
FRSS:
FSB:
FYI SUBMISSIONS:
GEMS:
GENE-TOX:
CIS:
GLOBAL 79:
GRB:
HANES II:
HERD:
HHS:
HWDMS:
IAEA:
IAO:
IARC:
IRL:
IRRS/CTS:
ICB:
Environmental Abstracts Online
Environmental Protection Agency
EPA Chemical Activity Status Report
Environmental Research Laboratory
Economics and Technology Division
Environmental Teratogen Information Center
Exposure Analysis Modeling System
Excerpta Medica
Food and Agricultural Organization
Food and Drug Administration
Federal Register Abstracts
Fish Reproductive Toxicity Data File
British Hydromechanics Research Association
Facilities Management Information System
Federal Register Search Service
Full Studies Branch
For Your Information Submissions
Graphical Exposure Modeling Systems
Mutagenicity Data File
Global Indexing System
A Fortran Program to Extrapolate Dichotomous
Animal Carcinogenicity to Low Doses
General Regulations Branch
Health and Nutrition Survey
Health and Environmental Review
Health and Human Services
Hazardous Waste Data Management System
International Atomic Energy Agency
Industry Assistance Office
International Agency for Research on Cancer
Information Retrieval Ltd.
Inventory Reporting Regulation
System/Correspondence Tracking System
Industrial Chemistry Branch
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VII-64
ICRS:
IFD:
IMSL:
ISHOW:
ISMEC:
IS SB:
ITC PROFILES:
ITC REVIEWS:
ITC TRACKING SYSTEM:
ITI:
IUPAC:
IUPHAR:
MANTELAN:
MEDLARS:
MEDLINE:
METADEX:
MOB:
MPTEA:
MRST:
MSB:
MSSS:
MULTILOG 80:
NBS:
NCI:
NFPA:
Index Chemicals Registry System
Industrial Facilities Discharge
International Mathematical and Statistical
Library
Information System for Hazardous Organics in
Water
Information Service in Mechanical Engineering
Information Support Services Branch
Interagency Testing Committee Hazard
Information Profiles
Interagency Testing Committee Hazard
Information Reviews
Interagency Testing Committee Tracking System
The International Technical Information
Institute
International Union of Pure and Applied
Chemistry
International Union of Pharmacology
Mantel-Bryan Low-Dose Extrapolation Model
Medical Literature Analyses and Retrieval System
Medlars Online
Metals Abstracts/Alloys Index
Management Operations Branch
Multiple Point Gaussian Dispersion Algorithm
with Optional Terrain Adjustment
Statistical Methodology for Toxicological
Research
Management Support Branch
Mass Spectral Search System
A Computer Program for the Risk Assessment of
Toxic Substances
National Bureau of Standard
National Cancer Institute
National Fire Protection Association
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VII-65
NHMS:
NIOSH:
NIOSHTIC:
NLM:
NOHS:
NPDES:
NRB:
NTIS:
NWDS:
OAQPS:
OB:
OCABS:
OCLC:
ODW:
OHM-TADS:
ONE HIT MD:
OPD:
OPP:
ORBIT:
ORNL:
OSHA:
OTS:
PAL:
PAPERCHEM:
PASCAL:
PERS:
PHYTOTOX/UTAB:
National Human Adipose Tissue Survey (Program)
National Institute for Occupational Safety and
Health
National Institute for Occupational Safety and
Health Technical Information Center
National Library of Medicine
National Occupational Hazard Survey
National Pollutant Discharge Elimination System
Notice Review Branch
National Technical Information Service
Bibliographic Data File
National Water Data System
Office of Air Quality Planning and Standards
Oncology Branch
Oceanic Abstracts
Online Computer Library Center
Drinking Water File
Oil and Hazardous Materials Technical
Assistance Data System
One-Hit Low-Dose Extrapolation Model
Oils, Pigments and Drugs
Office of Pesticide Programs
Online Retrieval of Bibliographic Information,
Timeshared
Oak Ridge National Laboratory
Occupational Safety and Health Administration
Office of Toxic Substances
Point, Area, Line Source Algorithm
Paper Chemistry Abstracts
Programme Applique a la Selection et a la
Compilation Automatiques de la Litterature
Personnel System
Phytotoxicity and Plant Uptake and Metabolism
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VII-66
PMN DATA:
PMN:
POLLUTION:
PPDB:
PPS:
PRE-CHIP:
PREFER:
PROMT:
PTS:
RANK TIME:
RANN:
RAPRA ABSTRACTS:
RIB:
RTECS:
RTF:
RTS:
SANSS:
SAS/ETS:
SAT:
SCI:
SDB:
SESOIL:
SOB:
SPHERE:
SPSS:
SRI:
STAR:
SWEMS:
SYMN:
Data Submitted Collected and Generated during
PMN Assessment
Premanufacturing Notification
Pollution Abstracts
Policy and Program Development Branch
Project Performance System
Pre-Chemical Hazard Identification Profile
Preferred Chemical Name
Predicasts Overviews of Marketing and Technology
Predicasts Terminal Systems
A Fortran Program for Risk Assessment Using
Dose-Response Data Time-to-Occurrence
Research Applied to National Need
Rubber and Plastics Research Association
Abstracts
Regulatory Impacts Branch
Registry of Toxic Effects of Chemical Substances
Research Triangle Park
Request Tracking System
Structure and Nomenclature Search Service
SAS/Econometrics and Time-Series Library
Structure Activity Team
Scisearch
Systems Development Branch
Seasonal Soil Model
Systems Operation Branch
Scientific Parameters in Health and the
Environment-Retrieval and Estimation
Statistical Package for the Social Sciences
Stanford Research Institute
Stability Tubular Array
Soil and Water Environmental Monitoring System
Synonyms of Chemical Names
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VII-67
TASRTP:
TDB:
TDIS:
TEB:
TED:
TERATOX:
TERRE-TOX:
TICIRC:
TLV:
THE DATA:
TOX-TIPS:
TOXLINE:
TRDB:
TSCA:
TSCAPP:
TSI:
TSSMS:
ULRI:
US CLASS:
USDA:
USITC:
USPA/USP77/USP 70:
UTM-TOX:
VAX:
UVCB:
WATERDROP:
WHO:
WNPI:
WPIL:
SDB Request Tracking
Toxicology Data Bank
Technical Data Indexing System
Toxic Effects Branch
Toxics Economics Database
Teratology Data File
Published Terrestrial Toxicity Data File
Technical Information Center Circulation Control
Threshold Limit Values
Data Submitted, Collected and Generated During
Test Market Exemption Assessment
Toxicology Testing in Progress
Toxicology Information Online
Test Rules Development Branch
Toxic Substances Control Act
Toxic Substances Control Act Plant and
Production Search System
Test Study Inventory
Time-Sharing Service Management System
Ulrich's International Periodicals Directory
and Irregular Serials and Annuals
U.S. Patent Master Classification File
United States Department of Agriculture
United States International Trade Commission
U.S. Patent Copies
Unified Transport Model-Toxics
An EPA Owned Computer Modelling System
Unidentified or Variable Composition, Complex
Reaction Product, or Biological Chemicals
Water Distribution Register of Organic
Pollutants
World Health Organization
World Patent Index
World Patent Index Latest
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VIII-1
VIII. DATA SUB-CATEGORIES/OTS FUNCTIONS MATRIX
This section is comprised of a series of matrices matching
data sub-categories (as described in Section IV of the Notebook)
against major OTS functions (as described in Section II of the
Notebook). The purpose of these matrices is to establish a
relationship between data sub-categories and OTS functions/
showing the types of information needed in support of each of the
functions. By comparing these matrices against the Date Sub-
categories/information Resources Matrix (See Section VII of the
Notebook), major information gaps can be easily identified.
No attempt is made to match data sub-categories against OTS
sub-functions. Such a matrix would be too complex to construct
and may be misleading.
In general, the matrices highlight the following points:
1. Certain types of data are exclusively used in support of
certain specific functions. These are:
Data Category
Chemical economics
Health effects
Environmental effects
Exposure
Regulations/Controls
OTS Function
Economics analysis
Health effects analysis
Environmental effects analysis
Exposure analysis
Regulatory options analysis
2. Other types of data are widely used to support more than
one function. They are:
Data Category
OTS Function
Physical/Chemical properties Chemical analysis
Control technology analysis
Exposure analysis
Health effects analysis
Environmental effects analysis
Production/Processing
Use/Disposal
Chemical analysis
Control technology analysis
Exposure analysis
Economic analysis
Chemical analysis
Control technology analysis
Exposure analysis
Economic analysis
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VIII-2
3. Substance identification data appear to be widely used
for supporting a number of the functions. This is not totally
unexpected since OTS' mission is the investigation of chemical
substances. Therefore, every function is chemically oriented and
the substance in question has to be properly identified. However,
it is believed that substance identification data are mainly used
in support of the chemical analysis function, and that the other
functions rely more on the results of chemical analysis for
identifying the substances. The matrix, in this case, does not
distinguish between gathering information directly from
information resources and obtaining information from a product
generated by a function that uses the information directly.
A total of nine matrices are presented, with each matrix
matching a data category against the OTS functions. The sub-
categories of a category are listed on the horizontal axis, and
the functions are on the vertical axis of each matrix.
Each matrix shows what specific data sub-categories within a
certain data category are used in support of the OTS functions.
As discussed in Section IV of this Notebook, certain sub-
categories may belong to more than one data category and cross-
references are used to denote this relationship. In the
aforementioned matrices, the cross-referenced sub-categories are
included in all of the pertinent matrices. For example, "Method
of Manufacture" appears in both the "Substance Identification vs.
OTS Functions Matrix" as well as the "Production/Processing vs.
OTS Functions Matrix." It is hoped tha the handling of cross-
referenced sub-categories in this manner will make each matrix
more complete and will allow the users to visualize immediately,
without going into another matrix, the relationship between a data
category and the functions.
As described in Section II of this Notebook, Regulatory
Options Analysis mainly integrates products from other functions
and has no specific information requirements except for data
pertaining to regulations and controls. For this reason,
information requirements for Regulatory Options Analysis are
indicated only in the "Regulations and Controls vs. OTS Functions
Matrix."
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IX-1
IX. DATA REQUIREMENTS FOR OTS PROCESSES
In Section III of this Notebook, the three major OTS
processes, i.e., New Chemicals Review, Existing Chemicals Review,
and Chemical Testing, are discussed. Associated with each of the
three processes in Section III are the major information
resources specifically designed or used in support of that
process. These information resources are mostly indexing or
tracking systems and do not include the traditional bibliographic
or non-bibliographic scientific and technical information systems
listed in Section V of this Notebook. This section defines data
requirements for the three OTS processes.
For the OTS functions (see Section II), information
requirements are identified in terms of data categories and sub-
categories (see Section IV). Furthermore, the computerized
scientific and technical bibliographic and non-bibliographic
information systems (see Section V) and manual sources (see
Section VII) containing pertinent data are presented. The data
requirements for the functions are indexed in matrices (see
Section VIII). Therefore, a direct relationship has been
established among OTS functions, data categories and sub-
categories, and information resources in terms of computerized
and manual scientific and technical systems. In general, an OTS
function is data specific, i.e., a function requires a specific
category of data. The data are usually available in specific
information systems.
The operation of OTS processes obviously needs support from
a variety of scientific and technical systems and sources that
are not included in Section III of this Notebook. However,
unlike a function, a process is not data specific. This is
because organizationally a process is largely supported by almost
all functions. While different functions require different data
categories, all data categories are required for a process since
all functions are involved. Therefore, as far as scientific and
technical data are concerned, the information requirements for
the three processes are essentially identical. Nevertheless,
each process may prescribe a slightly different responding time
and depth of data coverage, based on the specific time
constraints of that particular process. Additionally, each
process has different requirements in terms of specific indexing
or tracking systems, as discussed in Section III.
Instead of presenting a matrix matching a process against
specific data categories or sub-categories, as in the case of the
functions (see Section VIII), this section attempts to define
data requirements for the processes in a different manner. If
such a matrix were developed, almost all columns would be checked
for all three processes.
(a) A quick search of a few major data bases on the PMN chemical.
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IX-6
Existing Chemicals Review Process
Milestones
1. Entry Review
a. Step 1: substances not previously
evaluated under TSCA
b. Step 2: substances previously
evaluated under TSCA (From CHIP
or Section 4 Chemical Testing)
2. Problem Characterization
3. Information Gathering & Risk
Analysis
4. Risk Reduction Analysis
5. Risk Management
Data Categories
Substance identification
Health effects
Environmental effects
Production/processing
Use/disposal
Regulations/control
Health effects*
Environmental effects*
Exposure*
Physical/chemical properties
Health effects
Environmental effects
Production/processing
Use/disposal
Exposure
Chemical economics (Market
profile & substitutes)
Regulations/control
(handling and labeling)
Chemical economics
Information obtained from
above activities
Information requirements for CHIP. Literature search is limited
to secondary sources. For information requirements on Chemical
Testing, see the table entitled Chemical Testing Process: Test
Rules Development.
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IX-7
Chemical Testing Process
Test Rules Development
Milestones
1. Obtain data from ITC Report
2. Obtain unpublished health &
safety studies from industry
(Section 8(d) submissions)
3. Literature search for Testing
Needs Analysis (also from
Section 8(a) Level A submissions)
4. Preliminary Economic Analysis
5. Preliminary Exposure Analysis
6. Preliminary Testing Needs Analysis
7. Support Document
8. Economics Analysis Document
Data Categories
Substance identification
Production/processing
Use/disposal
Exposure
Health effects
Exposure
Regulations/control
Substance identification
Physical/chemical properties
Health effects
Environmental effects
Production/processing
Use/disposal
Exposure
Regulations/control
Production/processing
Chemical economics
Health effects
Environmental effects
Production/processing
Use/disposal
Exposure
Information obtained from
above activities
Same as 6
Information from 5
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X-l
X. CONCLUSION
The foregoing sections of this Notebook have identified
information requirements for the OTS functions and processes as
well as pertinent information resources and analytical capa-
bilities that are currently available. Wherever feasible,
matrices have been developed to highlight the relationship among
information requirements, information resources and analytical
capabilities, and OTS functions and processes. Furthermore, the
resources attributes matrices facilitate both user awareness of
the wide variety of information resources available and proper
selection of the most appropriate resource(s) to satisfy an
information requirement.
This section presents some analyses of the major findings in
the foregoing sections of this Notebook. Major conclusions of
these analyses are summarized as follows:
1. There are seven major functions and three processes
within OTS, and each of these functions or processes has certain
information requirements. In general, the information
requirements for a process is much broader than those for a
function. This can be explained by the simple fact that all
functions are involved in supporting a process by performing
technical and scientific reviews and analyses for that process.
Scientific and technical data are therefore needed directly in
support of these functions which in turn support the processes.
2. OTS has diversified information needs, based on the data
categories and sub-categories that have been identified.
Although all data categories and sub-categories are needed by
OTS, the relative value of each data category or sub-category to
the successful implementation of TSCA is, however, difficult to
determine.
3. In general, functions are .data specific. This means
that instead of requiring all types of data, a function usually
needs one or a few specific categories of data, as discussed in
Section VIII of this Notebook. For example, health effects
analysis requires essentially health effects data, and exposure
analysis needs data on exposure, physical chemical properties,
production/processing, and use/disposal of chemical substances.
4. Certain data categories are each exclusively used in
support of one function while some other categories are used by
more than one function. For example, chemical economics data are
used exclusively in support of economic analysis while use
information is needed for exposure analysis, economic analysis,
chemical analysis, as well as control technology analysis.
5. Processes are not data .specific. In general, a process
requires all kinds of scientific and technical information.
Therefore, unlike the functions, information requirements are
almost identical for the three OTS processes. Each process,
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L .
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X-2
however/ may prescribe a slightly different responding time and
different depth of the information coverage.
6. In addition to scientific and technical information, the
processes also require systems to track process management
decisions or to index submission data. As a result, several
tracking or indexing systems have been specifically developed to
support the processes. Examples of these systems include the
TDIS, PMN Tracking System, CECATS, 8(a) Level A Information
System, etc. Functions, on the other hand, use exclusively
scientific and technical information.
7. For each of the three processes, major milestones and
products are identified. In general, the preparation of these
products requires the support of a number of the OTS functions
and, therefore, a number of the data categories. In some cases,
a product may be data specific, i.e. it requires a specific
category of data. In any case, the same categories of data may
be needed for different products for a particular process, as
evidenced in Section IX of this Notebook. This may be explained
by one of the following:
o The two different products requiring similar information
may pertain to different chemicals, e.g., PMN subject
chemicals and PMN analogs.
o Although the information requirements are similar in
terms of data categories, the depth of coverage may be
quite different. For example, one product may require
only a quick search of a few major computer data bases,
while another product needs a more comprehensive search
including manual sources.
o Different products may be prepared at relatively the
same period of time. Similar information is needed
simultaneously in preparing these products. The time
constraints do not allow these products to be prepared
consecutively, so that the output from one product would
become the input for the next product.
8. The analytical capabilities developed by OTS are used to
support all three processes and essentially three functions, i.e.
health effects analysis, environmental effects analysis, and
exposure analysis. These analytical capabilities are used to
supplement the existing computerized and manual resources as a
source of information support for TSCA. Specifically, where
certain types of critical data are lacking, OTS uses the
analytical capabilities to develop data based on estimation or
modeling techniques. Examples include the use of estimation
techniques for generating physical/chemical properties, fate and
exposure modeling techniques for assessing chemical fate and
environmental or human exposure, and dose-response modeling
techniques for estimating relationships between dose level and
toxic effects.
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X-3
9. The existing computerized bibliographic and non-
bibliographic data bases alone cannot fully satisfy OTS
information needs. These data bases are being supplemented by
manual resources, expert opinions, and data development via rule-
making or estimation techniques. Specifically, OTS relies on
estimation techniques to develop many of the sub-categories for
physical/chemical properties, and on computer models for certain
kinds of exposure data. Furthermore, OTS uses manual and
unpublished resources and depends on expert opinions for certain
sub-categories of data on economics, production, processing, use
and disposal of chemical substances. Health and environmental
effects data in general appear to be more readily available in
the computer data bases, with the exception,of end-point and
testing data.
10. There are approximately 200 computerized and 500 manual
information resources which have been identified as pertinent
sources for supporting the OTS functions and processes. A series
of resource attributes matrices are developed to evaluate and
document the usefulness of these information resources. However,
the quality of either the data or the data bases cannot be
determined. Each of these information resources contains certain
information that is needed to support TSCA. Therefore, it will
be counter-productive to compare or rank these information
resources in terms of their relative usefulness or contribution
to TSCA. The successful implementation of TSCA requires many
different categories of data that are available from a wide
variety of information resources, i.e., bibliographic data bases,
non-bibliographic data bases, manual sources, unpublished data,
expert opinion, etc.
11. The bibliographic data bases (e.g. Toxline, Medline)
usually provide the users with abstracts and bibliographic
information, while the non-bibliographic data bases (e.g. RTECS,
SPHERE) contain end-point data or data in an extracted format.
OTS needs to use both types of data bases, since they contain
different data and serve different purposes. Different search
techniques must be used to search the two different types of data
bases. It appears that end-point data can be more readily used
if only a preliminary review of a chemical is conducted.
Abstracts and bibliographic data will be more useful for more in-
depth reviews of chemicals.
12. OTS does not seem to rely heavily on peer-reviewed
data. In fact, most of the scientists interviewed indicated that
they prefer to conduct their own analyses and draw their own
conclusions. However, in using the data bases, they would prefer
to have data with certain types of quality indicators.
13. OTS must more actively and effectively utilize existing
unpublished data. Currently, there does not seem to be a formal
mechanism for identifying and acquiring unpublished data,
especially those from other agencies.
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-------
X-4
14. In matching the data categories and sub-categories
against information resources the following trends and data gaps
are observed:
o All data categories are Covered to some extent by the
bibliographic and non-bibliographic data bases, and
manual resources.
o The technical aspects of chemical information (i.e.,
Substance Identification, Physical-Chemical Properties/
Health Effects/ and Environmental Effects) appear to be
adequately covered by the identified sources/ with the
exception of end-point and testing data.
o The technological and economic aspects of chemical
information (i.e., Production/Processing, Use/Disposal/
Exposure/ and Chemical Economics) need additional
sources. In many cases, expert opinions are being used.
o The legal aspects (i.e., Regulations/Control), with the
exception of the Consumer Affairs sub-category, are
covered but could use some additional sources.
o Of the 19 sub-categories for Chemical Economics, 7 sub-
categories (37%) have no source for data.
o Of the 16 sub-categories for Production/Processing, 4
sub-categories (25%) have no information source.
o For Use/Disposal category, 7 of the 12 sub-categories
(58%) have no source for data.
o Of the 23 sub-categories for Exposure, 4 subcategories
(17%) have no source for data.
o In the Health Effects Category, no information sources
are found for the Epidemiology sub-category, an
unexpected finding.
15. The TSCA Chemical Substances Inventory, in spite of the
apparent obsolescence of some of its data, is still the most
complete single source for production volume and manufacturing
plant site data. If more current data are needed, OTS must
obtain the data through rule-making.
-------
U S. Environmental P'?tec 'f
GLNPO LR>-y Collection (PL-
77 West Jackson Boulevard,
Chicago, IL 60604-3590
,. - - -Action Agency
U S En*. ,-,
^^ .; :.«!d. 12th Floor
Chicago, IL .OGU4-359Q
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