CONTROLLING DISINFECTION BY-PRODUCTS WITH ALTERNATIVE DISINFECTANTS
                                 by
                      Benjamin W. Lykins, Jr.
                               Chief
                Systems and Field Evaluation Branch
                  Drinking Water Research Division
                      Cincinnati, Ohio  45268
                         James A. Goodrich
                      Environmental Scientist
                Systems and  Field Evaluation Branch
                  Drinking Water Research Division
                         Wayne  E. Koffskey
                           Chief Chemist
          Jefferson  Parish Department of Public Utilities
                 Jefferson Parish,  Louisiana  70121
                                 and
                           Mark H. Griese
                               Manager
                     Water Quality and Research
                 Evansville Water And Sewer Utility
                     Evansville, Indiana  47740
                     1991  AWWA ANNUAL  CONFERENCE
                          PHILADELPHIA, PA
                          JUNE 23-27,  1991

                RISK REDUCTION ENGINEERING  LABORATORY
                 OFFICE OF RESEARCH AND DEVELOPMENT
                U.S. ENVIRONMENTAL PROTECTION AGENCY
                       CINCINNATI,  OHIO  45268

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CONTROLLING  DISINFECTION BY-PRODUCTS WITH ALTERNATIVE  DISINFECTANTS

                                 by
                       Benjamin W.  Lykins,  Jr.
                               Chief
                 Systems  and  Field  Evaluation  Branch
                         James  A.  Goodrich
                       Environmental  Scientist
                 Systems  and  Field  Evaluation Branch
                  Drinking Water Research Division
                Risk Reduction Engineering Laboratory
                U.S. Environmental Protection Agency
                       Cincinnati,  Ohio   45268
                          Wayne E.  Koffskey
                            Chief Chemist
           Jefferson Parish Department of Public Utilities
                 Jefferson Parish, Louisiana  70121
                                 and
                           Mark H. Griese
                               Manager
                     Water Quality and Research
                  Evansville Water And Sewer Utility
                     Evansville, Indiana  47740
INTRODUCTION
     Future Federal regulations for disinfection/disinfection by-
products will potentially effect most water treatment plants in the
United States.  In anticipation of proposing regulations in June
1993, the U.S. Environmental Protection Agency is in the process of
assessing the performance and potential health risks of several
drinking water disinfectants and their by-products.  In order to
provide field data for this assessment and to more thoroughly
understand the interactions of disinfection and disinfection by-
product control regarding the advantages and disadvantages of a
selected direction, studies were done at two drinking water
utilities.  This paper will discuss some of the results from these
studies which consisted of a pilot plant evaluation at Jefferson
Parish, Louisiana and bench-scale evaluations at Evansville, Indiana.

JEFFERSON PARISH. LOUISIANA PILOT PLANT

     For this study, raw river water from the Mississippi River was
pumped to the full-scale plant where it was clarified with diallyl-
dimethyl ammonium chloride or dimethylamine-type cationic polymers.
After fluoridation, but before disinfection a  portion of the clarified
water was filtered through pressure sand filters before going to a 10

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gallon-per-minute pilot plant.  This pilot plant was operated in a
conventional  mode with disinfection followed  by  sand  filtration.  Post
treatment consisted of granular activated carbon  after sand filtration.
Figure 1 shows the flow diagram for this mode of operation.

     Each disinfectant contact chamber was 12.75 inches (320 mm)
outside diameter and constructed of stainless steel.  The chlorine,
chloramine, and chlorine dioxide contact chambers were 10 feet (3m)
in height, producing approximately 30 minutes disinfectant contact
time with a flow of 2 gpm (0.13 L/s).  The ozone contact chamber was
11 feet (3.3m) in height, with countercurrent operation consisting of
water entering at the top of the contact chamber and ozone gas
entering at the bottom.  The water and ozone gas influent lines were
oriented so that the  influent water would be in contact with the
ozone gas stream for  approximately 30 minutes.11'

     Ozone was generated from compressed dry  air using an electrically
powered ozone  generator with a maximum  output  capacity  of 0.25 Ib/d
(0.11 kg/d).  Chloramine was produced by adding hypochlorous acid to
the water stream a few  seconds prior to the  addition of ammonium
hydroxide.  Chlorine  dioxide was generated using two solutions, one
containing sodium chlorite and sodium hypochlorite and the other
containing sulfuric acid. The final pH of the solution was  4. Chlorine
was  added  in  the form of hypochlorous acid.   Residual concentrations
after disinfection addition were maintained  through  the contact
chambers to be comparable to those  found in  many drinking water
utilities at the time the study was initiated.   Average residuals were
1.0 mg/L chlorine, 2.1 mg/L monochloramine, 0.5  mg/L  chlorine dioxide,
and  0.5 mg/L  ozone.   The nondislnfected process stream was identical
to the  disinfected process streams  except for elimination  of the
contact chamber.  The major objectives of this  study were to evaluate:
 (1)  the microbiological  effectiveness of the disinfectants, (2) the
control of halogenated by-products,  and  (3)  potential health effects
associated with  the  use of these disinfectants.

MICROBIOLOGICAL  EFFECTIVENESS

      All  of  the disinfectants at  the dosages used,  reduced the
coliforms to  acceptable levels.  However, with  heterotrophic bacteria,
 all  disinfectants except chloramines reduced the  levels to below  100.
However,  other organisms may not have been  as  effectively controlled
 by all  disinfectants.  For  instance,  during  one study when MS2
 Coliphage was spiked into the pilot plant, chloramines were  ineffective
 for this virus  indicator as  shown in Table 1. Additional studies  at
 Jefferson Parish will apply  the concentration  x time (C»t) concept
 for determining  disinfectant efficiency. An example of these C^t
 values  that  have been developed for inactiyation  of various
 microorganisms by the major  disinfectants is shown in Table 2.

 HALOGENATED  BY-PRODUCT CONTROL

      During  the one-year operation of the pilot plant,  two surrogate
 parameters that  give an indication  of organic concentrations including
 halogenated  by-products were evaluated:  total organic carbon (TOC) and
 total organic halide (TOX).   The average TOC concentrations  in  the
 disinfectant contact chamber effluents were 3.1,  2.9, 3.2, 3.2  and
 3.2 mg/L for the nondisinfected, ozone, chlorine dioxide,  chloramine,
 and chlorine process streams,  respectively.  There was some indication

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that ozone was reducing the TOC concentration while the concentration
of TOC was fairly constant for the other disinfectants.   Further  in the
treatment system after the ozone  sand column,  the TOC was reduced an
additional 0.8 mg/L when  compared  to the nondisinfected  system.  Based
on the levels of heterotrophic bacteria  in the effluents of the ozone
contact chamber and ozone sand column, the reduction of TOC across
the ozone contact chamber appears to  have resulted primarily from
oxidation while that across the ozone sand column can be attributed
to biodegradation.

     With an average nondisinfected influent concentration of 25 /xj/L,
TOX concentration increased significantly after 30 minutes of disinfec-
tant contact time for chlorine dioxide, chloramine, and chlorine  to 86,
99, and 246 /xj/L, respectively.  The  same trend  seen for TOC was also
observed  for TOX where an average reduction  of 33 percent occurred in
the ozone contact chamber producing an average effluent concentration
of  16  pg/L with  a  further  reduction to 11 pg/L  across the ozone sand
column.   Treatment  of  the  sand filtered effluents with free chlorine
followed by 5 day storage to  simulate the distribution  system signifi-
cantly increased TOX concentrations for all  process  streams (557, 540,
339,  and  379 jxj/L  for nondisinfected, chlorine, ozone, and chlorine
dioxide,  respectively).

     The trihalomethanes (THMs) reacted as expected with no significant
concentrations (1 /xj/L average) observed in  the  disinfectant contact
chamber and  sand column  effluents of  the nondisinfected, ozone, and
chlorine  dioxide process streams.   An average THM concentration of 3
jxj/L  occurred  in the chloramine disinfectant contact chamber and sand
column effluents while that  in the  chlorine  contact chamber effluent
averaged  39  /xj/L and increased to 49  /xj/L across the chlorine sand
column.   By maintaining  a chloramine  residual for 5 days, the terminal
THM concentrations  increased slightly to an  average of 8.5, 3.2, 4.2,
and 9.4 /xj/L for the nondisinfected,  ozone,  chlorine dioxide, and
chloramine process  streams,  respectively.   Similar  treatment and
storage with free  chlorine produced relatively  high terminal THM
concentrations for  the nondisinfected and chlorine  process streams
with  average concentrations  of 236  and 225  /xj/L. When compared to
the nondisinfected  sand  column effluent, terminal THMs were 35  and 41
percent less when ozone and chlorine dioxide  were used during pretreat-
ment  resulting in  average  concentrations of 154 and 138 jxj/L, respec-
tively.   As  expected,  granular activated carbon (GAC)  reduced all
concentrations until the columns  became saturated in  60 to 80 days.

      The  haloacetic acids  followed the same trend as  seen with  THMs
 except at a  lower concentration.   The highest  concentrations were
 formed using free chlorine which  mainly produced dichloroacetic acid
 (DCAA),  trichloroacetic  acid (TCAA),  and bromochloroacetic acid
 (BCAA).   Chloroacetic  acid (CAA),  bromoacetic acid (BAA), and
 dibromoacetic acid (DBAA)  were also formed to some extent.  Average
 instantaneous concentrations for dichloroactic acid were  0.9,  1.7,
 3.7,  1.1, and 13 /xj/L  for  the  nondisinfected,  chlorine dioxide,
 chloramine,  ozone,  and chlorine process streams  after sand filtration,
 respectively.  Five-day terminal values for the same  process  streams
 with free chlorine  were  60, 44, 38, and 60 /xj/L for the nondisinfected,
 chlorine dioxide, ozone, and chlorine streams,  respectively.

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     Similar treatment of the  sand  filter effluents with  chloramine
and a 5 day storage period resulted in only  slightly  elevated  DCAA
concentrations.  The slight concentration increase is similar  to that
seen for THMs during similar treatment with  chloramine suggesting
that both were formed by free  chlorine during  in-situ formation of
chloramine.  GAC adsorption produced continued removals of 80% or
greater of DCAA after steady-state  which was about 150 days of
operation. GAC steady-state was  reached in about  250  days for  DCAA
after storage for five days with a  free chlorine  residual.   After GAC
steady-state, average removals were 48, 73,  53, 46, and 51  percent
for the nondisinfected, ozone, chlorine dioxide,  chlpramine, and
chlorine process streams, respectively.  Similar  observations  for all
unit processes were seen for TCAA and DCAA.

     Relatively low concentrations  of haloacetonitriles were formed
across each process stream with  chlorine producing the highest levels
which averaged 3.1 A/g/L total  haloacetonitriles.  Less than  1 /xj/L
average of haloacetonitriles was observed across  the  other process
streams.  The predominant haloacetonitrile (HAN) was dichloroacetonit-
rile (DCAN) followed by bromochloroacetonitrile (BCAN), dibromoaceto-
nitrile  (DBAN),  and trichloroacetonitrile (TCAN).   Treatment of the
chlorine  sand  column  effluent   with additional  free  chlorine  and
subsequent 5-day storage produced an average concentration of 1.9 /xj/L
of DCAN which was the same as  that  of the sand column effluent
suggesting that all DCAN precursors had reacted.  No  consistent
breakthrough of the HANs was observed through  any GAC column except
that of the chlorine process stream, which was still  removing  over
95% of the influent HANs at the  end of the one-year operational
period.

     Only two haloketones, 1,  1, 1-trichloropropane  (TCP) and  1, 1-
dichloropropane (DCP) were detected with the highest  concentration
(1 to 2 /xj/L) being observed in  the chlorine process  stream.  Post
chlorination of the sand column  effluents followed by 5-day storage
produced similar TCP concentrations in each process stream with  average
concentrations of 2.1,  2.5, 4.2, and 2.5 /xj/L  for the nondisinfected,
ozone, chlorine dioxide, and chlorine, respectively.   Although
consistent breakthroughs of these haloketones  were observed across
the GAC columns, removals remained  above 85  percent throughout the
one-year operational period.

     Chloral hydrate  (CH) was  formed predominantly  in the chlorine
process stream with an  average contact chamber effluent concentration
of 2.9 /xj/L which increased to 4.5  jxj/L across the sand filter  because
of an additional 30 minutes chlorine contact time.  The CH concentra-
tions in the effluent of the chloramine contact chamber and sand column
were  identical averaging 0.25  /xj/L. CH was detected  intermittently in
the contact chamber and sand column effluents of the chlorine dioxide,
ozone, and nondisinfected process streams at average  concentrations
ranging  from 0.01 to 0.07 /xj/L.   Post-treatment of  the sand column
effluents with free chlorine and storage for  5 days produced relatively
similar CH concentrations averaging 79, 55,  45, and  75 /xj/L for the
nondisinfected, ozone,  chlorine  dioxide,  and chlorine process
streams,  respectively.   Similar  treatment with chloramine produced
average  concentrations  of 0.03 to 0.3 /xj/L.  GAC adsorption removed
all  of the CH  throughout the project in all  process  streams.

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     The concentrations of chloropicrin  (CP)  1n the effluents of the
disinfection contact chambers  and  the  sand  columns were the  same,
averaging 0.004, 0.004, 0.015,  0.038,  and 0.43 ^g/L for the  nondisin-
fected, ozone, chlorine dioxide, chloramine,  and chlorine process
streams, respectively.  Chlorination and 5-day storage of the sand
column effluents produced concentrations averaging 1.3, 7.7, 1.4, and
1.3 pig/L for the nondisinfected, ozone, chlorine dioxide, and chlorine
process streams, respectively.  Pre-ozonation appears to have produced
an increase in CP precursors.   Only slight  increases in CP
concentrations were observed after similar  chloramine treatment and
storage of the sand column effluents with average concentrations of
0.03, 0.04, 0.11, and 0.09 jXj/L for the  nondisinfected, ozone,
chlorine dioxide, and chloramine,  respectively.  No consistent
breakthrough of CP above 0.003 ^g/L was observed across the GAC column
of any process throughout the  operational period.

HEALTH STUDIES (Jefferson Parish.  Louisiana)

Sample Disinfection

     For the health-related studies at Jefferson Parish, a portion of
the clarified water after fluoridation was  filtered through  pressure
sand filters and split into four process streams as shown in Figure
2.  Three of these streams were disinfected with either chlorine,
chloramine, or ozone while the fourth  stream  was not disinfected and
served as a control.  Chlorine dioxide was  not evaluated at  this time
because it appeared that chlorine  dioxide would not be an acceptable
disinfectant when the disinfection/disinfection by-product regulation
was promulgated.  The system used  for  the three disinfected  streams
consisted of a contact chamber followed  in  series by a sand  column
and a 55-gallon stainless-steel  drum fitted with a spiral stainless-
steel baffle.  The modified drum served  as  an additional contact
chamber.  The system for the nondisinfected stream was similar except
that the initial contact chamber was omitted.  The contact time in
the contact chamber was approximately  30 min  for each of the
disinfected streams and the empty-bed contact time for the sand column
was approximately  20 min.   The ozone  stream  was split after the sand
column and post-disinfected with either  chlorine or chloramine.  As a
result of stream splitting, the flow rate to  the two post-disinfected
drums was decreased.  Therefore, the contact time for post-disinfected
drums was approximately 150-180 min while the  contact time for the non-
ozonated chlorine and chloramine streams and the nondisinfected stream
was approximately  85-100  min.   The amount  of chlorine and chloramine
added  to  the two ozonated streams was adjusted  so  that the residual
disinfectant concentration leaving the drums matched the corresponding
final  residuals  observed  for the  chlorinated and chloraminated (non-
ozonated) streams  (0.5-1.0 ppm C12 and 0.8-1.5 ppm NH2C1).

SAMPLE COLLECTION

     Macroreticular resins (Amberlite  XAD-8 and XAD-2) were  used to
collect and concentrate the organic compounds from the process streams
for chemical  and toxicoloaical testing.  The concentration  procedure
described by Miller et al.^5 was used with the following modifications.
Ethyl  acetate was  utilized instead of  acetone to elute the organic
material from the  XAD resins  and the ratio  of sample volume  to resin
volume was decreased from 760:1 to 150:1.   The change in ratio was

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made to minimize the potential breakthrough of MX, 3-Ch1oro-4
^d-\ch1oromethyl )-5-hydroxy-2(5H)-furanone, and compounds with similar
solubilities  in water.  The XAD resins were cleaned by Sohxlet
extraction with ethyl acetate and methanol for 24 hr and stored in
methanol.  Prior to sample collection, each column pair containing
5 L of XAD-8  and XAD-2 resin was flushed with 200 L of water to
remove the residual methanol.  Fifteen hundred liters of each of the
process streams were passed through the column pairs serially at a
flow rate of  60 L/min.  The pH of the column influent was maintained
at pH 2 by the in-line addition of 9N hydrochloric add.

     Following sample collection, each column was filled with
sufficient ethyl acetate to provide a standing  head.  The columns were
then agitated to  completely  wet  the resin and allowed to equilibrate
for 15 minutes.   Each  column pair was then eluted serially with 15 L
of ethyl  acetate.   Residual  water was removed from the ethyl acetate
extract by  allowing the water to separate  and  then  draining off the
water in  a separatory funnel.  Each extract was concentrated to
<1.5 L under  vacuum at 40°C  by  rotary evaporation.   The samples were
each adjusted to  exactly 1.5 L with  ethyl  acetate  before storing at
4°C.  Immediately  prior  to  chemical  or toxicity testing, aliquots of
the   1000X   concentrates   were   further  concentrated   by  rotary
concentration at 40°C.

RESULTS AND DISCUSSION

     Three rounds  of water sample concentrates were collected during
September 1989, March  1990,  and July  1990.  An examination of the
seasonal  effects  (early  fall-89, early spring-90, and mid summer-90)
of finished water  quality and surrogate parameters for the control
stream (non-disinfected  + sand) showed that the early spring sample
had the lowest values  for: pH (7.3), dissolved solids (184 mg/L), TOC
(2.8 mg/L), and TOX (15.7 ug/L).  The early spring sample also had
the lowest concentrations for eight volatile organics examined.  This
latter finding may simply be a consequence of the lower TOC levels-in
the spring sample  that may result from a  flushing of  naturally
occurring organic  matter from the source water over the course of the
winter.   However,  it should  be noted that TOX values observed for the
(C12 + sand)  and (NHXl + sand)  samples were highest  for the  spring
sample.   This suggested  that the nature of the precursor material was
different and that more  semivolatile and  nonvolatile halogenated
compounds were formed.  This  idea Is supported by the observed increase
in the formation of haloacetic acids.

     Significantly lower values were  also obtained for the spring
sample with regard to  brominated compounds  (bromodichloromethane,
dibromochloromethane,  and bromoform).  The most likely causes being
either a  decrease  in the bromide content  in the source water or an
increase  in the ammonia  level of the  source water that would result
in the formation of combined bromine rather than free bromine.  As
for the effect of  seasonal changes on the formation of halogenated
by-products,  the differences appeared to  be less well defined.
However,  the  over-all  formation of brominated DBFs was spring <
summer <  fall.

     Many of  the  halogenated by-products  of interest were analyzed
for each  disinfectant  stream. T6-7>8) Of special interest was the
potential concentration  of these by-products when water is delivered

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to the customer.  This was evaluated by storing samples  for  5 days
with a disinfectant residual  to simulate concentrations  in the
distribution  system.  An example of the effects of using different
disinfection  alternatives for the September  1989 sampling is shown  in
Table 3.   These data  show a definite trend.  For example, with
dichloroacetic acid,  when chlorine is added  prior to  and after sand
filtration about  45 jxj/L, on  average, was detected.   If  ozone is
added prior to sand filtration and chlorine  after sand filtration,
this average  concentration was reduced to 32 /xj/L.   If however,
monochloramine is used prior  to and after sand filtration, the
average  concentration is reduced to about 8  jug/L.  Further reductions
were seen when ozone  was added before sand filtration and monochlora-
mine after sand filtration  (4.6 pg/L average).  This  trend was seen
for other prevalent halogenated by-products  such as  trichloroacetic
acid, bromochloroacetic  acid, chloral hydrate, and  trichloromethane.

     A similar trend  is seen for preliminary health studies on samples
collected September 1989 at Jefferson Parish for bacterial mutagenicity
and DNA  strand breaks as shown in Table 4.   From these data,  one might
conclude that ozonation prior to sand filtration and  chloramination
after sand filtration will  solve the halogenated by-product  problem.
This  is  true  but  one  also has to evaluate the total  impacts  of
disinfection. For  instance,  although ozone  shows promise and may be
a viable disinfection alternative, assimilable organic carbon (AOC)
increase in the distribution  system has to be controlled.  This can
be done  by biostabilization of the water during treatment before
distribution. An example of  this  is shown  in Table  5.   In this
example, after ozonation, 162 /xj/L of AOC is present. Sand  filration
provides some biostabilization by  reducing the AOC to 38 pg/L while
the  GAC  effuent  is  4  pg/L;  comparable to the AOC concentration (3.7
pg/L) in the  chlorine contact chamber effluent.  Ozonation by-products
such  as  aldehydes,  ketones,  and acids  are  also  a concern.  Although
chloramines may be the disinfectant of choice to provide a disinfection
residual, it  may not provide the desired disinfection effectiveness and
there have been  some  health concerns with ingesting  chloramines.

EVANSVILLE. INDIANA STUDIES

      Another  potential  disinfectant for controlling  halogenated by-
products, is  chlorine dioxide which was further evaluated beyond the
scope  of the  Jefferson Parish project.  At  a drinking water  utility
on the  Ohio River,  a pilot  plant was used to compare chlorine dioxide
disinfection  with chlorine  disinfection1 '.   The  addition of chlorine
dioxide to the raw water with delayed  chlorination permitted coagula-
tion/settling/filtration and oxidation to remove trihalomethane precur-
 sors,  thereby reducing the  amount  of trihalomethanes formed  during
post-treatment chlorination.  A comparison  of the average trihalo-
methane concentrations for  the  two disinfectant modes showed a
reduction of approximately  60 percent  when  chlorine  dioxide  was used.
Although chlorine dioxide disinfection  can  reduce trihalomethane
concentrations,  control  of the metabolites  (chlorite and chlorate)  is
 essential before chlorine  dioxide  can  be considered  a viable
disinfection alternative.   Equipment  is now available to produce
 chlorine dioxide that is virtually free of  chlorine  and  chlorate.
 Bench-scale studies have recently  been completed which evaluated the
 reduction of chlorite and chlorine dioxide  by  a  reducing agent.U0)

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     All of the samples used for these studies were collected from
the effluents of pilot plant secondary setting basins after approxi-
mately 200 minutes of chlorine dioxide contact time.(11)  These grab
samples were analyzed  immediately for residual chlorine  dioxide (C102),
chlorite (CIO,),  and  chlorate (C103),  treated with  the  respective
reducing agent for a variety of contact times, and reanalyzed for the
same chlorine dioxide species.

     The major reducing agents considered for these studies consisted
of sulfur dioxide, sodium thiosulfate, sodium metabisulfite, and
ferrous iron.  For sulfur dioxide, complete reduction of residual
chlorine dioxide and chlorite ion was achieved but a marked increase
in chlorate ion concentration was consistently observed as shown in
Figure 3.  This same phenomenon occurred with sodium metabisulfite.
The degree of C102 reduction with sodium thiosulfate depended on pH
and contact time.  Removal of chlorite ion was demonstrated with
little or no chlorate formation.  However, the dosages required for
complete reduction appear to make this reducing agent impractical.
Ferrous iron appears to be an effective methodology for the removal
of chlorine dioxide and chlorite ion residuals.  Both of these
undesirable finished water residuals were eliminated in minutes at pH
6.0 to 7.0 and preliminary results indicate that excess reductant may
be easily controlled by pre-filter chlorination.

     Bacterial mutagenicity was evaluated using the same procedures
that were used at Jerfferson Parish, Louisiana.  Table 6 shows the
results of these tests using the TA 100  strain.  Regardless of whether
chlorine dioxide  or  ozone is used as a  predisinfectant,  when GAC is
incorporated into the  treatment scheme,  the mutagenicity is low when
compared to  the  non-disinfected stream.   Otherwise, when chlorine is
used as a post-disinfectant  the mutagenicity is high with both chlorine
dioxide or ozone predisinfection.

SUMMARY

     Regulations to control contaminants  in drinking water in the
United States are expected to become more stringent and more prevalent.
Forthcoming disinfection  and disinfection by-product regulations will
effect virtually every community water system.  There are various ways
to control disinfection by-products, one of which  is to use an alter-
native  to chlorine.  However, when this is done, one should consider
various aspects of each disinfectant.  There  appears to be no single
disinfectant that is applicable for all situations.

ACKNOWLEDGEMENTS

     The authors  acknowledge the assistance  of  Robert Miller, Paul
Ringhand, and Ron Dressman  for  their  help in  sample collection,
analyses, and data interpretation.  The authors also thank Kathy
Schenck and other members of the former Health  Effects Research
Laboratory.  Lastly, the  authors thank Sandra Dryer, Susan Campbell,
Cathie  Krekeler,  and  the  CSC  staff for helping  prepare this paper.

     This paper has been  reviewed  in  accordance with the U.S.
Environmental Protection  Agency's peer and administrative review
policies and approved  for presentation and publication.  Mention of
trade names  or commercial products does not  constitute endorsement or
recommendation for use by the USEPA.

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REFERENCES

1.   Lykins,  Jr.  B.W.,  Koffskey,  W.E., and Miller, R.6., "Chemical
     Products and Toxicologic Effects of Disinfection", Journal AWWA,
     78:11, 66-75, 1986.

2.   Hoff, J.C.,  "Inactivation of Microbial Agents by Chemical
     Disinfectants",  U.S. EPA, EPA/600/2-86/067, 1986.

3.   National Primary Drinking Water Regulations, Final Rule, Federal
     Register, 40 CFR Parts 141 and 142, Vol. 54, No. 124, Thursday,
     June 29, 1989.

4.   Korich,  D.G., Mead, J.R., Madore, M.S., Sinclair, N.A., and
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5.   Miller,  R.G., et al, "Results of Toxicological Testing of
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6.   Lykins, Jr., B.W., et al "Ozone for Trace Organic Contaminant
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7.   Lykins, Jr. B.W., Moser, R., and DeMarco, J., "Treatment
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8.   Lykins, Jr. B.W.,  "Disinfection of Drinking Water and Control  of
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9.   Lykins, Jr. B.W. and Griese, M.H., "Using Chlorine Dioxide for
     Trihalomethane Control", Journal AWWA, 78:6, 88-93,  1986.

10.  "Disinfection Byproduct Control Using Chlorine Dioxide", U.S.
       EPA  Cooperative Agreement No. CR-816837, 1990.

11.  Griese, M.H., et al., "The Use of Reducing Agents For the Total
     Elimination of Chlorine Dioxide  and Chlorite Residuals  in
     Drinking Water", Journal AWWA, 83:5,  56-61,  1991.
                                 10

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           TABLE  1.   JEFFERSON PARISH MICROBIOLOGICAL DATA



                                   MS2
                    RESIDUAL   COLIPHAGE     COLIFORM       HPC
STEAM                (mg/L)        (mL)        (100 ml)      (mL)

NONDISINFECTANT        -         400,000         640      43,000

OZONE                 0.3          <1             0          14

CHLORINE DIOXIDE       0.5           1             0          57

FREE CHLORINE         1.0          <1             0          44

CHLORAMINE            1.9        46,000           0         270
                                11

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       TABLE 2.  SUMMARY. OF C-t VALUE RANGES FOR INACTIVATION OF
            VARIOUS MICROORGANISMS BY DISINFECTANTS (2-3-4'
Disinfectant
Free Preformed Chlorine
Micro- Chlorine Chloramine Dioxide
orqanism oH 6 to 7 oH 8 to 9 oH 6 to 7
£». Coll 0.
Polio 1
Rotavirus 0
Phage f2 0
(L. lamblia
cysis
JL. muris
cysts
Crvptosporidium
parvum
NOTE: All C-t
Giardia
034-0.05
1.1-2.5
.01-0.05
.08-0.18
47->150
30-630
7200(b)
values are
lamblia and
95-180
768-3740
3806-6476
ND
2200(a)
1400
7200(c)
0.4-0.75
0.2-6.7
0.2-2.1
ND
26(a)
7.2-18.5
78(0
for 99% inactivation at 5°C
CrvptosDoridium parvum.
Ozone
oH 6 to 7
0.02
0.1-0.2
0.006-0.06
ND
0.5-0.6
1.8-2.0
5-10(b)
except for
(a)  Values for 99.9% inactivation at pH 6-9
(b)  99% inactivation at pH 7 and 25°C
(c)  90% inactivation at pH 7 and 25°C

ND - no data
                                  12

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TABLE 3.  JEFFERSON PARISH DISINFECTION  BY-PRODUCT FORMATION
           POTENTIAL  FOR SELECTED STREAMS (SEPTEMBER 1989)
                   Concentration in jtg/L
BY-PRODUCT
Chloroacetic
Acid
Dichloracetic
Acid
Tri chloro-
acetic Acid
Bromoacetic
Acid
Dibromoacetic
Acid
Bromochloro-
acetic Acid
Dichloro-
acetonitrile
Trichloro-
acetonitrile
Dibromochloro-
acetonitrile
Bromochloro-
acetonitrile
1,1-Dichloro-
propane
1,1,1-Trichloro-
propane
Chloropicrin
Chloral Hydrate
Trichloromethane
Bromodichloro-
me thane
Dibromochloro-
methane
Tribromo-
methane
TOX
NONDIS.
0.
0.5
0.2
0.
o.
0.2
0.1
0.
0-
0.
0.1
0.
0.
0.
1.0
0.4
0.1
0.1
27.
SAND-
16.0
44.9
39.8
1.2
0.8
28.7
1.6
0.1
0.3
0.7
0.1
1.8
0.9
37.5
156.
35.0
8.
0.
505.
OZONE -
SAND-
Cl,
17.0
32.3
19.0
1.0
1.2
20.2
1.3
0.
0.4
0.7
0.1
1.7
4.2
32.6
121.
29.0
.10.0
1.0
328.
NH2C1- OZONE-
SAND- SAND-
_NH2C1_ NH,C1
0.4 0.6
8.2
1.7
0.1
0.1
3.8
0.
0.
0.
0.
0.
0.
0.
0.1
5.3
1.2
0.1
0.
55.
4.6
0.7
0.1
0.1
1.4
0.
0.
0.
0.
0.
0.
0.
0.
1.8
0.5
0.1
0.1
29.
                            13

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TABLE 4.  PRELIMINARY HEALTH STUDY RESULTS ON JEFFERSON PARISH
                 CONCENTRATES  (SEPTEMBER 1989)
TREATMENT
Non Disinfect
C12
03 + C12
NH2C1
03 + NH2C1
BACTERIAL
MUTAGENICITY
(REVERTANTS/L)
142 ± 18
4185 ± 181
2152 ± 78
1420 ± 31
972 ± 36
DNA STRAND
BREAKS
f BREAK/CELL-LI
44.5 ± 0.2
680.9 ± 5.0
311.3 ± 7.0
201.8 ± 3.0
76.0 ± 4.0
                             14

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      TABLE 5. AVERAGE AOC CONCENTRATION
               AT JEFFERSON PARISH, LA
     TREATMENT                     AOC.ug/L

NON DISINFECT                        13.5

03CONTACT CHAMBER                   162.

03-SAND                              38.2

03-SAND-6AC                           4.0

ClCONTACT CHAMBER                    3.7

C12-SAND-GAC                          2.6
                      15

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  TABLE 6. BACTERIAL MUTAGENICITY RESULTS ON
           EVANSVILLE CONCENTRATES
     TREATMENT                     REVERTANTS
                                   PER LITER
Nondisinfect                        505 ± 24
C102 + Fed, + Cl, +
  dual media + CT2                 3437 + 64
C102 + GAC + C12                     771 ± 26
03 + dual  media  + C12               3770 ± 47
03 + GAC + C12                       867 ± 24
                      16

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