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 ERRATA SHEET for EPA' s Draft Dioxin Reassessment                           6/15/00

 PART IE:   Integrated Summary and Risk Characterization for 2,3 ,7,8-
              Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds

 1) See attached page for correction to Authors and Contributors

"2) Section 5.2.1.2 Estimates of Slope Factors and Risk at Current Background Body Burdens
 Based on Animal Data            ~
    Paragraph 1 -                 -                    :
        •   Sentence 6 should read: "...a slope factor of 1 .8 x l;Q-5 per pg TCDD/kgBW/day..."
        •   Sentence 12 should read: "... for (BW)%-scaling..."
        •   Sentence 13 should read: "...intake values at the ED01..."

    Paragraph 2 -        -                               :
        •   Sentence 8 should read: "Again...than does the unadjusted estimate."

 3) Section 6. RISK CHARACTERIZATION

 Under bolded heading "Complex mixtures of dioxin and related compounds are highly
 potent, "likely" carcinogens."                           '
    Paragraph 6 (Starts with "Risk estimates for intakes associated with...") -
        •   Sentence 8 should read: "Based on these slope factor estimates, upper bound cancer
           risks from average..."

 Under bolded heading "Background exposures to dioxin and related compounds need to be
 considered when evaluating both hazard and risk."
    Paragraph 4 (Starts with "Because dioxin levels in the environment...") -
        •   Sentence 5 should read: "... from 3 16 individuals..."
        •   Sentence 8 should read: "PCBs 105, 118, and 156..:reported by CDC  (2000)."
        •   Sentence  10 should read: "Assuming that the missing congeners  from the CDC
           study... another 3.3 pg TEQ/g lipid for a total PCB TEQ of 5.3 pg/g lipid and a total
           DFP TEQ of 25.4 pg/g lipid."

 Under bolded heading "Evaluation of exposure of "special" populations  and developmental
 stages is critical to risk characterization."
    Paragraph 4 (Starts with "Consumption of unusually high amounts of fish...") -
        •  Sentence 4 should read: "People who consume large quantities offish at estimated
           contamination levels may have elevated exposures."

 Under bolded heading "Many dioxin sources have been identified and emissions to the
 environment are being reduced."
     Paragraph 8 (Starts with "The contribution of reservoir sources to  human exposure...") -
        •  Sentence should read: "CDD/CDFs in waterways can bioaccumulate  in fish-leading  to
           human exposure via consumption of fish."

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AUTHORS AND CONTRIBUTORS

William H. Farland
Director
National Center for Environmental Assessment
Office of Research and Development
U.S. Environmental Protection Agency
Washington, DC

Linda S. Bimbaum
Director
Experimental Toxicology Division
National Health and Environmental Effects Laboratory
Office of Research and Development
U.S. Environmental Protection Agency
Research Triangle Park, North Carolina

David H. Cleverly
Exposure Analysis and Risk Characterization Group
National Center for Environmental Assessment
Office of Research and Development
U.S. Environmental Protection Agency
Washington, DC

Michael J. DeVito
Experimental Toxicology Division
National Health and Environmental Effects Laboratory
 Office of Research and Development
 U.S. Environmental Protection Agency
 Research Triangle Park, North Carolina

 Matthew N. Lorber
 Exposure Analysis and Risk Characterization Group
 National Center for Environmental Assessment
 Office of Research and Development
 U.S. Environmental Protection Agency
 Washington, DC

 John L. Schaum
 Group Chief
 Exposure Analysis and Risk Characterization Group
 National Center for Environmental Assessment
 Office of Research and Development
 U.S. Environmental Protection Agency
 Washington, DC

 Bruce D. Rodan
 Senior Health Scientist
 National Center for Environmental Assessment
 Office of Research and Development
 U.S. Environmental Protection Agency
 Washington, DC

 Dvvain L. Winters
 Director
 Dioxin Policy Project
 Office of Pollution Prevention and Toxics
 Office of Prevention, Pesticides, and Toxic Substances
 U.S. Environmental Protection Agency
 Washington, DC

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