United States
                  Environmental P
                  Agency
5EPA
ERA'S
           ,-
          ection
        Pesticides And
        Toxic Substances
        (H-7506-C)
21T-1005
May 1991
Pesticide
                                                       Printed on Recycled Paper

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        CONTENTS
        Introduction
              Overview of EPA's Role
              Facts and Figures

        Pesticide Registration
              How EPA Regulates New Pesticides
              Reregistration of Existing Pesticides
              Evaluating Scientific Studies
              Special Review, Cancellations, and Suspensions

        Food Safety
              Setting Pesticide Tolerances
              Monitoring Residues

        Other Pesticide Programs
              Farmworker Safety
              Home, Lawn, and  Garden Pesticides
              Pesticide Storage and Disposal
              Certification and Training
              State Enforcement
              Pesticides in CJround Water
              Endangered Species
              Biological Pesticides
              Inert Ingredients
              Preventing Pollution

        A Closing Word

        Appendices:

              Glossary
              For  Further Information
              EPA Pesticide Contacts
              State Agency (Contacts
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Photo on p. 11 courtesy ofS.C. Delaney/EPA; p. 15: Fish and Wildlife Service;
p. 18: Gene Alexander, USDAfSCS.

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 Introduction

 Few chemicals have had as much
 impact or been the subject of as
 much controversy in recent
 decades as pesticides.  Introduced
 on a massive scale following the
 Second World War, pesticides
 have become  an integral part of
 American agricultural production,
 making possible the most plentiful
 and safest food supply in human
 history. Over time, however,
 public concerns have mounted
 about the toxic effects of chemical
 pesticides.  Pesticide residues in
 food,  farmworker exposure to
 pesticides, and pesticide
 contamination of 'ground water
 have all contributed to a growing
 unease over the widespread use
 of pesticides.

 Some of these concerns have had
 beneficial results.  Consumers are
 using  more caution in handling
 pesticides and in limiting their
 exposures to pesticides in food.
 In the agricultural community,
 many growers  are using fewer
 chemical pesticides and adopting a
 more integrated approach to
 managing pests. And new
 pesticides coming on the market
 tend to be less toxic than the
 chemicals they replace.  While all
 of these are encouraging signs,
pesticides nevertheless  remain a
fact of our daily lives.  Managing
pesticides to minimize their risks
and maximize  their benefits is the
task we face.
 The U.S. Environmental
 Protection Agency (EPA) has
 been, charged by Congress with
 the job of regulating the use of
 pesticides and balancing the risks
 and benefits posed by pesticide
 use.

 To carry out this task, EPA has
 developed a variety of regulatory
 and isducational programs to
 protect human health and the
 environment from the harmful
 effects of pesticides.  These
 include registering pesticides for
 specific uses, setting tolerances for
 pesticide residues on food, setting
 standards to protect workers who
 are exposed to pesticides,
 certiiying and training pesticide
 applicators, and educating
 consumers about pesticide use  and
 exposure.

 This booklet is intended to
 introduce readers to EPA's
 pesticide programs.  Pesticide
 registration and food safety  are
 discussed first, followed by
 descriptions of other pesticide
 programs.  The appendices at  the
 back of the booklet contain a
 glossary of technical terms, a list
 of materials for further  reading
 and reference, and  the addresses
 and telephone numbers of
pesticide program contacts in
EPA headquarters and 10 regional
offices and in all 50 states.
 Overview of EPA's Role

 EPA regulates the use of
 pesticides in the United States
 under the authority of two laws
 — the Federal Insecticide,
 Fungicide, and Rodenticide Act
 (FIFRA) and the Federal Food,
 Drug and Cosmetic Act.  No
 pesticide may legally be sold or
 used in the United States unless  it
 bears an EPA registration
 number.  It is a violation of the
 law for any person to  use a
 pesticide in a manner  inconsistent
 with its label.

 EPA's pesticide regulations cover:

 •  Some 30 major pesticide
   producers plus another 100
   smaller producers
 •  3,300 formulators
 •  29,000 distributors  and other
   establishments
 •  40,000 commercial  pest control
   firms
 •  About 1 million farms
 •  Several million industry and
   government users
 •  About 90 million households.

FIFRA gives EPA the authority
and responsibility for registering
pesticides for specified uses,
provided that such uses do not
pose an unreasonable risk to
human health or  to the
environment.  EPA also has the
authority to suspend or cancel the
registration of a pesticide if
subsequent information indicates
that use of the pesticide would
pose unreasonable risks.

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Facts and Figures

Broadly defined, a pesticide is any agent used to kill
or control undesired insects, weeds, rodents, fungi,
bacteria, or other organisms.  Thus, the term
"pesticides" includes insecticides, herbicides,
rodenticides, fungicides, nematicides, and  acaracides, as
well as disinfectants, fumigants, and plant growth
regulators.

At present, approximately 25,000 formulated pesticide
products are registered for marketing and use in the
United States.  EPA regulates these products primarily
on the basis of their pesticidal active ingredients, the
component of a pesticide product that  acts on the
pest.  There are fewer than 750 active ingredients
currently in production, with 200 leading  active
ingredients.

Total U.S.  annual pesticide consumption  is estimated
at 2.7 billion pounds of active ingredients.  Of this
amount, 1.6 billion pounds represents wood
preservatives, disinfectants, and sulfur (a  fungicide).
The remaining 1.1  billion pounds of "conventional
pesticides"  (herbicides, insecticides, and fungicides)
were sold to users  at a cost of $7.4 billion in 1988.

In the conventional pesticide market (see Figure 1),
agriculture accounts for over two-thirds of pesticide
user expenditures and about three-quarters of the
volume used annually; the remainder of the market
comprises industry, government, and home and garden
800 •

700-

600-

500'

400'

300

200

100

  0
          millions Ibs. a,i.
                       • Herbicides
                       19 Insecticides
                       D Fungicides
                       0 Other
660
           Agriculture   Ind/ConVGovt  Home & Garden   Total
       / - VduneofComentionalPesticideAetivelngcedients Used in U.S., 1988
                       uses.  Herbicides are the leading type of conventional
                       pesticide, with over 50 percent of both domestic sales
                       and volume used.  EPA estimates that total U.S. farm
                       expenditures on pesticides, $5.1 billion in 1988,
                       represents less than 4 percent of total farm production
                       expenditures ($132 billion in 1989).
                                                            Alachlor

                                                            Atrazine
                                      Trifluralin

                                   Cyanazine

                                   Carbaiyl
                                 Matathion

                                Metribuzin
                           Fig. 2-Annual Usage of the Largest Agricultural Pesticides in the U.S.

                       The 10 largest-use agricultural pesticides are shown in
                       Figure 2, along with estimates of their annual usage
                       for all agricultural and non-agricultural uses.  Alachlor
                       and atrazine are the two  most widely used pesticides
                       by volume.  Eight of the  10 pesticides shown are
                       herbicides (carbaryl and malathion are insecticides.)
                           1200-

                           1000-

                            800-

                            600

                            400
                            200
                                million Ibs. a.i.
                                                                Total
                                                                                             Agricultural
                                 64 66 68 70 72 74 76 78 80 82 84 86 88
                                 Fig. 3 - Trends in U.S. Pesticide Usage, 1964-1988

                        After increasing steadily throughout the 1960's and
                        1970's, pesticide usage reached its all-time high in the
                        early 1980's; since then, it appears to be holding
                        steady at just slightly lower levels  (see Figure 3) and
                        may decline in coming years.  More efficient use of
                        pesticides, the availability of even more effective
                        pesticides, and an increased interest in sustainable
                        agriculture contribute to this trend.

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Pesticide Registration


How EPA Regulates New
Pesticides

EPA is responsible under FEFRA
for registering new pesticides to
ensure that, when used according
to label directions, they will not
pose unreasonable risks to human
health or the environment.
FIFRA requires EPA to balance
the risks of pesticide exposure to
human health and the environ-
ment against the benefits of
pesticide use to society and the
economy.

Pesticide registration decisions are
based primarily on EPA's
evaluation of the test data
provided by applicants.
Depending on the type of
pesticide, EPA can require up to
70 different kinds of specific tests
(see box).  For a major food-use
pesticide, testing can cost the
manufacturer up to $10 million.

Testing is needed  to  determine
whether a pesticide has the
potential to cause adverse  effects
on humans, wildlife, fish, and
plants, including endangered
species.  Potential human risks,
which are identified by using the
results of laboratory tests, include
acute toxic reactions, such  as
poisoning and skin and eye
irritation, as well as possible long-
term effects like cancer, birth
defects, and reproductive system
disorders. Data on "environ-
mental fate" (how a pesticide
 Basic Data Requirements for a New Food-Use ^Pesticide

 At the present time, data from the following tests must be submitted
 to EPA by a manufacturer prior to registrations
 Chemistry:
Environmental Fate:
Ecological Effects:
                               Ifet of ingredients
                               description of manufacturing process
                               discussion of formation of impurities
                               physico-chemical properties
                               residue studies
                               metabolic studies
                               analytical methods
                               results of analytical procedures
                               hydrolysis
                               leaching
                               terrestrial dissipation
                               photodegradatfon
                               soil metabolism
                               rotational «rop study
                               acute oral
                               acute dermal
                               acute respiratory
                               eye irritation
                               chronic toxteity
                               subchronie Oral tOxieity
                               reproduction and fertility
                               metabolism
                               mutagenicity
                               birth, defects
                               carcinogenicity
                               aquatic^ acute toxuaty
                               avian, dietary & acute oral

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behaves in the environment) also
are required so that EPA can
determine, among other things,
whether a pesticide poses a threat
to ground or surface water.  The
list of tests required is currently
undergoing review; revisions are
expected to be proposed in 1991.
Certain additions to the list, such
as neurotoxicity, applicator
exposure, ground and surface
water contamination, and
residential exposure tests, will
strengthen the data  requirements.

EPA may classify a product for
restricted use if it warrants  special
handling due to its toxicity.
Restricted use pesticides may be
used only by or under the
supervision of certified applicators
trained to handle toxic chemicals
and this classification must be
shown on product labels.  During
registration review, the Agency
may also require changes in
proposed labeling, use locations,
and application methods.  If the
pesticide is being considered for
use on a food or feed crop, the
applicant must petition EPA for
establishment of a tolerance (see
the section on Food Safety
below).

A brand-new active ingredient
may need six to nine years  to
move from development in the
laboratory, through  full
completion of EPA registration
requirements, to retail shelves.
This time-frame includes at least
two or three years to obtain
registration from EPA A
diagram of the process is shown
in Figure 4 on the next page.
Since 1978, when EPA began
requiring more extensive data on
pesticides than in the past, over
130 brand-new chemical active
ingredients have been  registered;
between 10 and 15 new pesticide
active ingredients are registered
each year.

Reregistration of  Existing
Pesticides

EPA is required by law to
reregister existing pesticides that
were originally registered  before
current scientific and regulatory
standards were formally
established.  The reregistration
process ensures that:

(1)  Up-to-date data bases are
developed for each of these
chemicals (or  their registrations
will be suspended or cancelled)

(2)  Modifications are made  to
registrations, labels,  and tolerances
as necessary to protect human
health and the environment

(3)  Special review or other
regulatory actions are  initiated to
deal with any unreasonable risks.

Reregistration has proved to be a
massive undertaking and has
proceeded slowly. To date, EPA
has issued 194 "registration
standards."  A registration
standard includes a comprehensive
review of all the available data  on
an existing chemical, a list of
additional data needed for full
reregistration, and the Agency's
current regulatory position on the
pesticide.  The 194 registration
standards already issued represent
about 350 individual active
ingredients that account for 85 to
90 percent of the total volume of
pesticides used in the United
States.

Under the 1988 FIFRA
amendments, EPA has been
directed to accelerate the progress
of reregistration so that the entire
process is completed by 1997.
FIFRA '88 sets out a five-phase
schedule to accomplish this task
with deadlines applying to both
pesticide registrants and EPA It
was originally estimated that
EPA's reregistration activities
would cost in excess of $250
million over a nine year period,
with almost half the amount
coming from EPA's current
budget for reregistration and the
remainder coming from
reregistration fees assessed on the
pesticide industry. These cost
estimates  are being revised
upwards to reflect actual  costs
incurred in the accelerated
program.

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                      Product Development:
               Product discovery
               Laboratory & greenhouse testing
               Experimental use permit obtained from EPA
               Large-scale field testing
                            Application:
                 Registrant submits test data, application
               to register product, draft labeling, & tolerance
                     petition (for food-use pesticide)
                       Registration Review:
          Review of Data:
              - toxicology            - ecological effects
              - residue analysis        - exposure assessment
          Are data valid?
          When used according to label directions, does the pesticide
          pose unreasonable risks of adverse effects to human health
          and the environment?
        Approval:
  EPA establishes tolerance
    for food use pesticide,
approves registration, publishes
  notice in Federal Register
                   Returned:
           EPA returns application, noting:
           •  need for more or better data
           •  need for labeling modifications
           •  need for use restrictions
 Producer markets product for
    use according to label
1
  Figure 4 - Pesticide Registration Process for New Chemical

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Evaluating Scientific
Studies

Because virtually all of EPA's
decisions relating to the
registration of pesticides depend
on the Agency's evaluation of
scientific studies, EPA has
developed a standardized review
process and established
procedures and testing guidelines
to ensure the quality and
consistency of toxicity studies.

How much data to require in the
flrst place and how much should
be generated again in the
reregistration process are
important issues. For example,
long-term animal studies usually
require two or more years to
complete, at a significant cost to
the registrant, and using
significant numbers of animals.
Thus, it is not a trivial matter to
require additional  studies to  be
performed.  At the same time, it
is crucial that registration
decisions be based on conclusive
scientific information and that all
products be evaluated consistently.

In light of these considerations,
EPA has set forth four types of
documents governing the
generation and review of data.
These are:

(1)  Data requirements — what
data must be generated to support
registration and reregistration;
(3)  Standard evaluation
procedures — guidelines for
Agency reviewers on what to look
for in the data and how to reach
consistent conclusions; and

(4)  Good Laboratory Practices —
regulations that specify how
studies must be conducted to
assure the quality and integrity of
data submitted to support
pesticide registration and
reregistration.  EPA's laboratory
audit program also  serves as a
further check on the  quality of
pesticide.safety data.

Nevertheless, there still may arise
differences in professional
judgment about whether a
particular study satisfies a data
requirement or whether data can
be used from multiple studies to
fill data requirements.  Therefore,
major evaluations made by EPA's
staff may be submitted for review
to  an independent  panel of
experts, known as the Scientific
Advisory Panel. In addition, the
bases for EPA's regulatory
decisions  are subject to public
review so that everyone has an
opportunity to look at the science
supporting the Agency's decisions.
Special Review,
Cancellations, and
Suspensions

New data on registered products
sometimes reveal the existence of
a problem or a potential for
hazard that was not known at the
time of registration.  Congress
and EPA have developed various
mechanisms to reach sound
scientific decisions in these
situations.

Special Review:  Under the law, if
EPA seeks to revoke the
registration of a pesticide, the
Agency must first announce its
reasons and offer the registrant a
formal hearing to present
opposing evidence.  Because the
cancellation process can be very
time- and resource-consuming,
EPA often will employ a more
informal and often more
productive process known as
Special Review.

Special Review is an intensive and
systematic examination process
that offers opportunities for
interested parties on all sides to
comment and present evidence on
the risks and benefits of a
pesticide. In many cases, the
Special Review results in an
agreement to  modify the
registration to sufficiently reduce
risk so that a formal hearing is no
longer necessary.
 (2)  Data guidelines — protocols
 for how to conduct the studies;

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 Cancellation:  If the Special
 Review process fails to resolve
 the issues, however, or if EPA
 decides that the problem is severe
 enough to warrant cancellation,
 EPA may issue a proposed notice
 of intent to cancel without
 holding a Special Review. The
 Agency also is required by FIFRA
 to send the proposed notice to
 the Scientific Advisory Panel and
 the U.S. Department of
 Agriculture (USDA), and must
 evaluate their comments before
 proceeding with a final Notice of
 Intent to Cancel Registration.

 If no hearing is requested within
 30 days  of the notice, the
 pesticide's registration is cancelled
 immediately.  If a hearing is
 requested, it is conducted in a
 trial-like administrative proceeding
 before an EPA Administrative
 Law Judge, who issues a
 recommended decision to the
 EPA Administrator. At the end
 of the cancellation process, which
 may take two years or more, the
 decision may still be challenged in
 a federal court of appeals. If
 there is no appeal to a decision
 to cancel, all pertinent
 registrations of the pesticide are
 automatically cancelled, and the
 products may no  longer be sold
 or distributed  in the United
 States.

Suspension:  During the entire
cancellation process, the pesticide
remains on the market and no
regulatory restrictions are  imposed
on the pesticide or its use. In
some cases EPA may believe that
allowing the pesticide to stay on
 the market — during a Special
 Review and/or a cancellation
 hearing — would pose an
 unacceptably high risk.  In such
 cases, EPA may issue a
 suspension order that bans sale or
 use of the pesticide while the
 ultimate decision on the
 pesticide's status is under review.

 In order to issue a suspension
 order, EPA must find that use of
 the pesticide  poses an imminent
 hazard.  In most cases, EPA must
 first offer the registrant an
 expedited hearing on the
 suspension issues. However, if
 EPA. finds that an emergency
 exist!} (i.e., that even during the
 time needed for a suspension
 hearing, use of the pesticide
 would pose unreasonable adverse
 effects), the Agency can ban the
 sale and use  of a pesticide
 effective immediately.

 Under current law, even in an
 emergency suspension, EPA must
 assess the benefits of the pesticide
 as well.  This  provision makes
 emergency suspension difficult  to
 use, and EPA has been able to
 make these findings only three
 times for major pesticides —
 ethylene dibromide (EDB);
 2,4,5-T/Silvex; and dinoseb.
 Proposals have been made that
would streamline the existing
cancellation process and make the
suspension process more flexible.
 Food  Safety

 The food supply of the U.S. is
 among the safest in the world.
 Although many of the foods we
 consume may contain low levels
 of pesticide residues as a result of
 the legal use of these products,
 numerous safeguards are built into
 EPA's pesticide regulatory process
 to ensure that the public
 (including infants and children)
 are protected from unreasonable
 risks posed by eating pesticide-
 treated foods.

 EPA regulates the safety of the
 food supply by setting tolerance
 levels, or maximum legal limits,
 for pesticide residues on food
 commodities and animal feed
 available for sale in the United
 States. The purpose of the
 tolerance program is to ensure
 that U.S. consumers are not
 exposed to unsafe levels of
 pesticide residues in food.

 Pesticides can be registered under
 FIFRA .for use on a food or feed
 crop only if a tolerance (or
 exemption from tolerance) is first
 granted,  under authority of
 sections 408 and/or 409 of the
 Federal Food, Drug and Cosmetic
 Act.  EPA has approved about
 300 pesticides for food  uses;
 about 200. of them are in common
 use in the U.S.

Setting Pesticide Tolerances

Pesticide tolerances are being
reassessed as part of EPA's
reregistration process.  Since
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residue chemistry and toxicology
are far more advanced now than
when pesticides were first
registered in this country, EPA is
upgrading its traditional tolerance
system.

To evaluate the risks posed by
pesticides in the diet, EPA follows
Agency risk assessment guidelines.
For non-cancer effects, when
using the results of animal tests,
EPA determines the highest level
of exposure to a pesticide at
which there are no observed
adverse effects hi animals.  An
"uncertainty factor" is applied to
that level (most often, by dividing
by 100) in order to estimate a
level of daily exposure  to the
pesticide acceptable for humans.
This  level is called the Reference
Dose (once known as the
Acceptable Daily Intake).

EPA also estimates the levels of
people's exposure to pesticide
residues in food, based on
pesticide residue studies as well as
studies of how much food people
consume. Using data on both
toxicity and exposure, the Agency
sets tolerances at levels that will
 not pose significant dietary risks
 to the consumer.  EPA usually
will deny a registration if the
 anticipated exposure from a
 proposed new food use of a
 pesticide, when added  to
 estimated exposure from other
 food uses of that pesticide,
 significantly exceeds the pesticide's
 Reference Dose.

 In cases where a food-use
 pesticide is a carcinogen (cancer-
causing agent), EPA uses a
second approach in addition to
that discussed above.  EPA
assesses the cancer risk specifically
associated with exposure to the
pesticide in food over the course
of a lifetime.  EPA then
determines whether that cancer
risk can be considered "negligible."
In general, EPA will  grant a
tolerance and register any
pesticide that poses a negligible or
no-cancer risk.

The concept of a  negligible risk is
the attempt to set a standard
below which the cancer risk is so
small that there is no cause for
worry from a regulatory or public
health perspective. EPA's
pesticide program defines a risk as
negligible if a person has a one-
in-a-million or less chance of
getting cancer as  a direct result of
a lifetime of exposure to a
particular substance.  (By contrast,
the overall risk to the U.S. public
of getting cancer, from all factors,
is on the order of one in four or
one in five.)

For pesticides that pose a cancer
risk that is greater than negligible,
there are two different policies,
 depending on the situation.  For
 pesticides that require  only a
 section 408 tolerance (i.e.,
 residues in raw agricultural
 commodities), EPA will register
 the pesticide if its benefits
 outweigh the risks posed by its
 use.  If, however, a  pesticide also
 requires clearance under the food
 additive provisions of FFDCA
 (section 409), then EPA cannot
 by law grant a tolerance or
 "I afn, encouraged  by  the
  increased   interest   and
  participation of the public in
  the  issue? of food safety* , •
  Informing   the   public
  accurately   and  truthfully
  about'risks  is in itself an
  essential part of protecting
  the putilic interest.

  HH pndaKsher, EPA Assistant
  ' ''Administrator, Pesticides
     and Toxic Substances
register the pesticide if it poses a
greater-than-negligible risk, no
matter how significant the
benefits.

Monitoring Residues

The pesticide tolerances set by
EPA are enforced by the Food
and Drug Administration, which
monitors all domestically produced
and imported foods traveling in
interstate commerce except meat,
poultry, and some egg products.
FDA conducts a Total Diet Study,
also known as a Market Basket
Study, which measures the
American consumer's daily intake
of pesticide residues from foods
that are bought in typical
supermarkets and grocery stores,
and prepared or cooked as they
would be in a household setting.
The findings of the ongoing Total
Diet Study show that dietary
levels of most pesticides are less
than one percent of  the
Reference  Dose.
 8

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 Imported foods receive special
 attention in FDA's monitoring
 program.  Above-tolerance
 residues  in 1987 and 1988 were
 found in less than one percent of
 import samples. Even so, FDA
 has tightened its import  policy in
 the last few years: if a single
 shipment from  a given source is
 found to violate U.S. tolerance
 regulations,  all  shipments from the
 same source are subject  to
 automatic detention.

 Monitoring of meat  and poultry
 products is conducted  by USDA's
 Food Safety and Inspection
 Service (FSIS).  Each  year, FSIS
 conducts 10,000 to 20,000
 pesticide residue analyses.
 Currently, fewer than one percent
 of these tests show illegal
 residues,  and the violation rate
 has  been declining steadily over
 the  last two decades.  State
 regulatory agencies are also
 involved in monitoring the safety
 of the food supply; some states
 have their own  pesticide residue
 regulations for food produced  and
 sold within state boundaries.

 In summary, EPA believes that
 foods containing legal levels of
 pesticides are safe, that continued
 regulatory review and action are
 serving to reduce and eliminate
 unnecessary risks, and that the
 overall risks  from pesticides in the
 diet are small compared to the
 benefits of the plentiful,
 nutritious, and affordable food
supply that we enjoy in the
United States.
EPA"s tolerance-setting system is designed to protect the average person against
both short-term and any long-term harmful effects of exposure to pesticides in
food.

However,  some people,  especially  infants  and  children*  tend to receive
significantly higher than average exposures, at least for some portion of their
lives. Children and infants lypieally eat more food in relation  to their 'body
weight and more of certain types of food (such as milk) than the average adult.
In setting  tolerances, therefore, EPA takes into account the potential risks to
children and infants, as well as to over 20 other subgroups in the population.

Although  EPA believes that its  approach  to setting tolerances adequately
protects the young, the Agency has contracted with the  National Academy of
Sciences to study this issue and report on any recommended changes  in
approach.  This study is due in  the spring of 1991,

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Other Pesticide

Programs


Farmworker Safety

EPA is making a concerted effort
to safeguard farmworkers' health
through a combination of
regulatory, educational,  and
research  programs.  Despite
regulations issued in 1974,
significant numbers of pesticide
poisonings among agricultural
workers continue to occur every
year. In 1988, EPA proposed
new Worker Protection Standards
to strengthen  the earlier worker
protection provisions, reduce risks
of exposure to pesticides, and
extend coverage to include
persons who engage in  hand labor
tasks or  handle pesticides on
farms,  or in forests, nurseries, and
greenhouses.  Final new
regulations will be issued in 1991.

The proposed new standards will
reduce the risk of exposure to
pesticides by:

* Requiring  that general
   pesticide safety rules be
   posted in a prominent location
   and that workers be notified
   of all pesticide applications.

 • Requiring  training for
   pesticide handlers and use of
  . appropriate personal
   protective  equipment during
   handling activities.
•  Prohibiting workers (other
   than handlers) from being
   present in a pesticide-treated
   area during application.

.  Imposing interim reentry
   intervals for the most acutely
   toxic chemicals until these
   chemicals can be evaluated in
   the reregistration process.

.  Requiring that potable water,
   soap, and disposable towels be
   made available to pesticide
   handlers and workers in
   treated areas for washing off
   pesticide residues.

EPA also is undertaking a variety
of outreach activities, including
preparing a user's guide to the
regulations, poster materials,  and
slide and tape programs in
English and Spanish that will help
communicate these safety
measures to farm workers and
farm owners.
  Information  on  the  health
  effects  of  pesticides  and
  pesticide   poisonings   is
  available 24 hours a day from
  operators at the EPA-funded
  National   Pesticide   Tele-
  communications    Network
  operating out of the  Texas
  Tech  University  School  of
  Medicine.

          Call toll-free:
         1-800-858-7378
Home, Lawn, and Garden
Pesticides

A wide variety of pesticides used
in homes and on lawns and pets
are readily available to consumers
in retail stores.  No special
training is required to use these
products; consumers are expected
to follow the instructions on the
pesticide label.   However, many of
these products can be hazardous
if improperly stored, handled, or
applied.

Household pesticides are coming
under a systematic review as part
of the Agency's  reregistration
process. EPA also is studying
whether household pesticide labels
are adequate to fully inform the
user of potential health or
environmental hazards.

Indoor Air

An emerging concern is the level
of pesticide residues in indoor  air.
EPA recently conducted a limited
monitoring study,  the Non-
Occupational Pesticide Exposure
Study (NOPES), which measured
exposures  in some 250 households
in Florida and Massachusetts.  Of
the 32 pesticides monitored, all
were detected at least once in  an
air sample, but  the levels found
were minute and were determined
to  present little or no concern for
 adverse health effects.  This study
was too limited to draw any broad
 conclusions about residential air
 quality, but it will help set the
 Agency's course for future
 research.
 10

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 Lawn Care

 As part of the reregistration
 process, EPA is reviewing
 individually the 35 major lawn
 pesticides.  In addition, EPA is
 reviewing the current set of data
 requirements for lawn care
 products in order to determine if
 additional potential hazard
 information should be generated.

 EPA believes that homeowners
 and residents are unlikely to
 receive long-term or chronic
 exposure to lawn care pesticides.
 Even intensiyely managed lawns
 generally receive  a maximum of
 five pesticide applications a year.
 Furthermore, highly toxic
 pesticides  are not registered for
 home use.

 Nevertheless, EPA encourages
homeowners and  the pest control
industry to follow integrated pest
 management (IPM) practices that
 reduce reliance on pesticides
 while still allowing healthy,
 attractive lawns to be maintained.
 For example, in properly
 maintained lawns, the thick
 healthy turf will crowd out many
 weed species; if grass is  cut at the
 proper height, watered, aerated,
 and fertilized properly, the
 incidence of fungus disease will be
 lessened.  A number of pest-
 resistant grass varieties and low-
 maintenance ground cover plants
 are available commercially.

 EPA is working with state and
 local  governments to develop IPM
 plans, guidance documents, and
 research papers on IPM
 technology for home lawns and
 golf courses. (See the appendix
 for recent IPM publications and
fact sheets on home gardening
and lawn care.)
                                                    Even though
                                                    pesticides are
                                                    familiar and
                                                    frequently used items
                                                    in a household?
                                                    reading the label is
                                                    ALWAYS necessary.

                                                    For tips on the safe
                                                    use of pesticides,
                                                    write fof the free
                                                    brochure^ "A
                                                    dtizen*s Guide to
                                                    Pesticides,* U.S.
                                                    EPA, Public
                                                    Information Center?
                                                    401 M Street SW,
                                                    Washington, DC
                                                    20460,
 Pesticide Storage and
 Disposal

 Pesticide wastes result from the
 use of pesticides in agriculture,
 industry, households,  and various
 other pest control operations.
 Pesticide wastes appear in a
 variety of forms: empty containers,
 left-over pesticides, and excess
 dilute pesticide solutions resulting
 from left-over tank mixes, spray
 equipment rinsate, and rinsing of
 empty containers.

 FIFRA '88 significantly expanded
 EPA's authority and responsibility
 to regulate the packaging, storage,
 transportation, and disposal of
 pesticides.  EPA may now require
 pesticide producers to submit data
 on storage and disposal methods;
 EPA may also establish labeling
 requirements for transportation,
 storage,  and disposal of pesticides
 and their containers.  The new
 law also strengthens EPA's ability
 to take direct enforcement action
 against violations  of storage,
 disposal, and transportation
 requirements.  Under  FIFRA '88,
 registrants will have significant
 new responsibilities in assuring
 that pesticide wastes are
 minimized and that any eventual
 disposal is carried out in an
 environmentally sound manner.

 If a pesticide is suspended and
 cancelled, EPA now has the
 authority to order the  recall of
 the product and its eventual
disposal at the producer's expense.
The recall of products by
manufacturers is the most efficient
                                                                                                           11

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and environmentally sound
method of consolidating stocks of
cancelled and suspended products.

EPA also will be studying the
problems associated with pesticide
container disposal, and examining
options to encourage or require:

.  The return, refill, and reuse of
   pesticide containers

•  The development and use of
   pesticide formulations that
   facilitate the removal of
   pesticide residues from
   containers

•  The use of refillable
   containers to reduce the
   number of pesticide containers
   requiring disposal.'

This study was due to be
submitted to  Congress by
December 1990, with regulations
on the design of pesticide
containers to follow in 1991.  The
regulations are intended to
facilitate the safe use, disposal,
and refill and reuse of pesticide
containers.  FIFRA '88 also
authorizes EPA to establish
procedures for storage, transport,
 and disposal  of containers,
rinsates, or other materials  used
 to contain or collect excess or
 spilled pesticides.
,Recycling Pesticide Containers in Mississippi

 In a pilot project begun m May  1989  in Washington  County, Mississippi,
 pesticide users'were asked to rinse, collect, and recycle their empty pesticide
 containers.  Metal containers were hauled to a metaiwork plant in Greenville,
 Mississippi, where they were melted at a high temperature, destroying all
 remaining residues,  Plastic containers were crushed and baled in an old cotton
 gin, then shipped to Ohio and pulverized into flakes and pellets for recycling.
Certification and Training

Pesticides with a restricted use
classification can be applied only
by a certified applicator or under
a certified applicator's direct
supervision.  There are currently
over 100 federally registered
restricted use pesticides and some.
1.25 million applicators holding
valid certification.  Applicators
include both "private" applicators
(mostly farmers) and "commercial"
applicators.
Because FIFRA gives the states
the opportunity to administer
their own certification program,
certification requirements vary
from state to state. All states,
however, must meet the minimum
federal requirements established
by EPA

Certification programs currently
are conducted by all states except
Colorado (where EPA administers
the program for private
applicators) and Nebraska (where
EPA administers the program for
all applicators).
 12

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The law does not require
pesticide applicators to be trained;
however, the law does require
certified applicators to
demonstrate competency with
respect to the use and handling of
pesticides.  EPA has issued
standards for determining the
competency of commercial and
private applicators for certification
purposes.

Both EPA and USDA fund,
develop, and distribute training
materials for certified applicators.
Under an interagency agreement
between EPA and USDA, EPA
funds are passed through USDA
to state extension service training
programs.  Each state has at least
one extension specialist on
pesticide use and safety.  Efforts
are underway to strengthen state
training programs, particularly in
relation to  ground-water
contamination and endangered
species protection.

State Enforcement
FIFRA includes provisions for
monitoring the distribution and
use of pesticides, and imposing
civil as well as criminal penalties
for violations. For example, it is
unlawful under FIFRA to use a
registered pesticide product in a
manner inconsistent with its label,
to alter the label, or to distribute
in commerce any adulterated or
misbranded product.  FIFRA also
authorizes "cooperative
enforcement agreements" between
EPA and the states.
Since 1978, the states have been
given primary enforcement
responsibility for pesticide use
violations, subject to oversight by
EPA  Through cooperative
enforcement agreements, all states
except Nebraska and Wyoming
have now assumed primary
enforcement responsibility. EPA
sets FIFRA enforcement policy
and conducts compliance
monitoring and enforcement
programs in these two states.

On an annual basis, EPA issues
national  Consolidated Pesticide
Cooperative Agreement Guidance,
which outlines the national
enforcement priorities and
activities that every state, tribe,
and: territory must address under
its enforcement cooperative
agreement.  EPA also issues
national  compliance monitoring
strategies in follow-up to every
major pesticide regulatory action
to help ensure consistency in
enforcement activities across the
country.

Cases of pesticide misuse or
acciidents should be reported to
the state agency with
responsibility for pesticides —
generally the state department of
agriculture (see appendix at the
back of this booklet).  Such cases
also may be reported to an EPA
regional office (see  appendix).
Pesticides in Ground
Water

Ground water is the vast
underground accumulation of
reservoirs that supplies wells and
springs.  Nearly half of all
Americans get their drinking
water from private or community
wells that tap ground water.  Our
dependence on ground water to
meet drinking water needs is
growing.  In some rural areas,
ground water accounts for up to
95 percent of the water used for
domestic purposes.

Pesticides can enter ground water
in a variety of ways — through
pesticide spills, improper storage,
or even as a result of normal
application of pesticides in the
field. The extent to which
ground-water contamination can
occur depends on  a variety of
factors: the chemical/physical
properties of the pesticide, the
frequency and quantity of
pesticide applied, the
characteristics of the soil, and the
geology of the area. These
factors, working singly  or in
combination, influence the
movement of a pesticide through
the soil and whether or not it will
leach into ground water.

When pesticides do enter ground
water, there may be a potential
risk to the health of those who
drink and use the water.   In  1988,
the Agency's Pesticides in Ground
Water Data Base showed that 46
pesticides had been found in
                                                                                                           13

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ground water in 26 states as a
result of normal agricultural use.

In response to these findings,
EPA has undertaken a number of
activities.  In 1989 EPA published
Health Advisories for 55
pesticides to assist federal, state,
and local officials in responding to
the contamination of drinking
water.  The Health Advisories
contain information about the
pesticides and their uses, the
health risks associated with
drinking water containing
particular concentrations of
pesticides, and testing and
treatment methods for removing
the pesticides from the water.
Summaries of the Health
Advisories can be obtained by the
public  through EPA's Safe
Drinking Water Hotline (1-800-
426-4791).

Recently, EPA set standards that
regulate 17 pesticides in drinking
water,  setting Maximum
Contaminant Levels for the
pesticide contaminants in
community water  system wells and
establishing monitoring and
reporting requirements.

In addition, in a major effort to
determine the extent of the
problem of pesticides in drinking
water wells, EPA has undertaken
a National Pesticide Survey  of
drinking water wells (see box).

EPA also is preparing to publish
a final Pesticides in Ground-
Water Strategy based on extensive
analysis and consultation with
farmers, other business
organizations, environmentalists,
and government officials at all
levels. The strategy will define
the Agency's goal of preventing
adverse effects on current and
potential sources of drinking
water. States play a key role in
achieving this goal by developing
and implementing state
management plans to identify
areas most vulnerable to
contamination and by tailoring
appropriate prevention and
management measures to local
conditions.  EPA will issue
guidance for the management
plans that will specify the
necessary components of an
acceptable plan.
  National Pesticide Survey

  "The   National   Pesticide
  Survey was the first Study of
  its kind to t>e conducted on
  a national scale,  Between
  1988 ' and * 19!W,  EPA '
  sampled 1,350 wells located
  in'all  50 states  for  the
  presence  of  over   10Q
  pesticides and for nitrates,

  .Preliminary results indicate
  that  10 percent  of  the
  nation's Commuiiity drinking
  water wells and about four
  percent  of rural domestic
  drinking water wells  have                                        ,>„,,
  -detectable residues of at least one pesticide. However, fewer than one percent'
  of all wells have concentrations of pesticides above levels of health concern.
  (Of the  wells with detectable levels of one or more pesticides, EPA estimates
  that 10  percent of community wells and 20 percent of rural domestic'wells
  exceed health, advisory or maximum contaminant levels.) The most frequently
  detected pesticides were dacthal metabolites and atrazine. More than half the
  nation's  wells  contain  nitrates,  but  fewer than  three  percent  have
  concentrations above the level of health concern.

  A final  report on tlie survey will be available in 1991. Detailed information
  collec|ed in the survey — on hydrogeological conditions, patterns of pesticide
  use,  and well characteristics — will  help EPA regulate pesticides  that can
  contaminate well water.
14

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Endangered Species

             Each species plays
             an interdependent
             role in the dynamic
             functioning of a
             healthy and stable
             environment,
storing a wealth of genetic
information that has taken
millions of years to  develop  and
perfect.  Despite increased
concern over the need to protect
endangered and threatened
species, the world continues to
lose entire species at an alarming
rate.  Over 500 plants, animals,
fish, and birds currently  are  listed
as endangered  or threatened in
the United States; some of these
species may be harmed directly or
indirectly by exposure to
pesticides:

Under the Endangered Species
Act, federal agencies must ensure
that any action they carry out or
authorize is not likely to
jeopardize  the  continued existence
of any listed species, or  to destroy
or adversely modify  its critical
habitat.  EPA's registration of
pesticides is considered to be
"authorization"  under the
Endangered Species Act.
Therefore, EPA is required  to
ensure that the registration of
pesticides and their  use  are  not
likely to jeopardize endangered
species.

In July 1989, EPA proposed an
Endangered Species Protection
      A steady rise  in  bald eagle populations  lias  occurred since EPA
      cancelled the legislations of J>PT for most uses in the early 1970>s.
      Absorption of these pesticides through the food chain had brought the
      birds to Ihe brink of extinction.  From estimates as low as 400 nesting
      pairs in the early 1960's, their numbers improved to over 2,660 nesting
      pairs itt the lower 48 states in 19&9.  On the basis of this recovery, the
      Fish and Wildlife Service is considering whether or not to reclassily the
      bald eagle as threatened rather than endangered.
Program aimed at protecting listed
species from harmful exposure to
pesticides, while avoiding placing
any unnecessary limitations on
pesticide use.

EPA's new program evaluates
potential pesticide impacts by
focusing first on listed species
whose status is most fragile. In
cooperation with USDA and the
Fish and Wildlife Service (FWS),
EPA will gather information on
the habitats and locations of these
species, and determine whether
the species may be affected by
pesticides to which they are likely
to be exposed.  If so,  as required
by the law, EPA will formally
consult with FWS to determine if
these pesticides will jeopardize the
continued existence of the species.
In cases where FWS finds that
EPA actions are required to
protect the species,  EPA will
institute use limitations on the
pesticides.
                                                                                                              15

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The Endangered Species
Protection Program will be
implemented through product
labeling and county bulletins.
The pesticide labels will instruct
users that use of the product
within each county must comply
with the limitations set forth in
the bulletin for that county.  The
label will also list a toll-free
phone number that pesticide users
can call to find out whether  or
not their county is affected by the
program. Bulletins will be made
widely available  through  a variety
of outlets.

EPA is encouraging states to
recommend protective measures
tailored to the listed species
located within each state.  Until a
final program is developed and
pesticide registrants are required
to modify their labels,  EPA will
be relying on a voluntary interim
program to help protect
endangered species.
Biological Pesticides

Natural and Genetically
Engineered Microbials

Certain microorganisms, including
bacteria, fungi, viruses,  and
protozoa, have been found
effective as pesticidal active
ingredients.  EPA has registered
over 20 naturally occurring
microbial  pesticides, which are
currently used in over 100
products in agriculture,  forestry,
mosquito  control, and home  and
garden applications.
As a class, natural microbial
pesticides usually exhibit several
desirable characteristics — they
tend to be effective in controlling
the target organisms without
adversely affecting other
organisms; they usually do not
have toxic effects on animals and
people; and they do not leave
toxic or persistent chemical
residues in the environment.
Because of this "safe" use history,
natural microbial pesticides are
not subject to the same stringent
registration requirements as
chemical pesticides.  However,
manufacturers are still required to
register them as pesticides if they
are intended for commercial use,
and the microbials must still
undergo certain testing
requirements.

With recent advances in
biotechnology, there has been
considerable interest in genetic
engineering of microorganisms to
produce pesticides that are as
effective and less toxic than
chemical pesticides.  At the same
time, there has been concern that
the experimental applications of
genetically altered microbes could
result in unforeseen risks to  the
environment.  Such microbes, for
example, may not be subject to
natural biological or environ-
mental control mechanisms when
introduced into the environment.

As a result of this concern,  EPA
evaluates certain  genetically
engineered microbial pesticides
before they are applied in the
environment.  Manufacturers are
always required to obtain
experimental use permits (EUPs)
for any large-scale field study of a
pesticide.  In addition, in 1984,
EPA published a notice requiring
the Agency to be notified at least
90 days prior to small-scale  field
testing of genetically engineered
pesticides.  Regulations specifying
the notification and information
requirements for small-scale field
tests of genetically engineered
pesticides are being prepared.

Biochemicals

Biochemicals are chemicals that
are either naturally occurring or
identical to  naturally occurring
substances.  Examples  include
hormones, pheromones, and
enzymes.  Biochemicals function
as pesticides through non-toxic,
non-lethal modes of action,  such
as disrupting the mating patterns
of insects, regulating growth, or
acting as repellents.  Like many
microbials, biochemicals tend to
be more environmentally
compatible and are thus important
to integrated pest management
programs.  They tend not to
disrupt beneficial organisms and
do not generally pose risks of
mammalian  toxicity or  human
health  effects.

Over 30 biochemical pesticides
have been registered by EPA
Although these substances must
still go through the registration
process, EPA allows for reduced
testing requirements for
biochemicals in order to promote
their use.
16

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Inert Ingredients

In addition to containing active
ingredients, virtually all pesticide
products contain one or more
inert ingredients.  Typical inerts
are solvents (water, petroleum
distillates, or alcohols), carriers
(talc, sand, or corn meal) and
surfactants (soaps or detergents).
By definition, inert ingredients are
not "active" in attacking a
particular pest.  However, some
inert ingredients  are chemically or
biologically active and may cause
health and environmental
problems. Prior  to 1987, the
majority of inert  ingredients  had
received EPA clearance but  had
been subject to relatively little
scientific scrutiny.

In 1987, EPA published an Inerts
Strategy which calls for the use of
the least toxic inert ingredients
available. For new inerts,
clearance requests must include a
minimum "base set" of data that
allows  EPA to determine whether
or not exposure to the inert  will
result in unreasonable adverse
effects.  Existing  inerts have  been
placed in groups  based on their
known toxicity and the need for
additional toxicity testing.

EPA is concentrating its attention
on the higher priority inerts. Of
some 50 substances identified by
EPA as presenting potential
toxicological concern, all but a
few have now been eliminated  by
registrants from their products; in
the interim,  manufacturers must
relabel products to identify the
presence of these toxic inerts.  A
second group of about 65 inerts
has been identified as
representing potential toxic
concern and a high priority for
testing.  EPA is evaluating these
chemicals as additional
information becomes available to
determine the risks of their
continued use.
Preventing Pollution

In line with an Agency-wide
priority on preventing pollution,
EPA is promoting the
development, and expediting the
registration, of safer alternatives
in pest control.  EPA is also
looldng to build into  the review
process for existing pesticides an
increased emphasis on non-
chemical alternatives  to problem
pesticide uses.  Other specific
initiatives are being developed in
integrated pest management and
in sustainable agriculture.

Integrated Pest Management

For the urban environment, EPA
has been developing an integrated
pesit management (IPM) strategy.
Elements of that strategy over the
next few years will likely include:

•   Support for research to
    develop biological and cultural
    alternatives to traditional
    pesticides
•  An emphasis on the
   development of integrated
   systems to forestall the build-
   up of resistance to any single
   control measure

•  Building strong public/private
   partnerships involving
   government, industry, users,
   universities, and private
   organizations to promote rapid
   transfer of new pest
   management and crop
   production technologies to
   growers and other users.

EPA is participating in the
International Pest Resistance
Management Congress, to  be held
late  in 1991, which will bring
together representatives  from both
industrialized and  developing
countries.  The Congress will
establish a global communication
network and data  base on
pesticide resistance and successful
management strategies.

Sustainable Agriculture

Pesticide use in agriculture is
increasingly coming under scrutiny
in the context of preventing
pollution and achieving a
sustainable agricultural system.

Several features of the current
system of American agriculture
detract from its "sustainability"
over the long term.  These
include  a heavy reliance  on fossil
fuels; cropping systems that
degrade soils and water;
chronically low economic returns
that  continue to force some
                                                                                                             17

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fanners, particularly family
farmers, out of business; and
environmentally damaging use of
synthetic pesticides and inorganic
fertilizers.

The long-term solutions to
agricultural pollution, like the
sources themselves, are highly
diverse.  But certain methods hold
considerable promise.  They
include: rotating crops, scouting
fields to determine actual pest
populations, the use of pest
resistant crop varieties,  recycling
animal manures, and the use of
biologically based methods of pest
control. The intent is to minimize
the need for pesticides, conserve
soil or enhance soil productivity,
and make  farming systems  more
sustainable.

To support USDA in fostering
sustainable agriculture, EPA is
generating and distributing
information that will assist in a
voluntary shift in agricultural
practices over the long term.
Particularly important are
demonstration and education
projects emphasizing more
environmentally  benign production
practices which also sustain yield
and net farm income.  EPA is
working with USDA officials to
increase their emphasis on these
programs and to use their  field
presence to educate farmers on
pollution prevention and
sustainable agriculture.
A Sustainable Agriculture Initiative

A joint project was initiated in March 1991 to allow farmers, extension agents,
and crop consultants to use a computer model in their weed management
decisions.  Participating in the project are EPA Regions 7 and 8, EPA's Office
of Pesticide Programs, the XJ»S. Department of Agriculture,, and agriculture
experiment stations and universities in Minnesota, Illinois, and Colorado.

The computer model to be distributed is an expert system containing ten* years
of .research data with overjLSO herbicide/cultural options for corn and* corn
rotations,  plus -their projected  yields  and costs.   Growers  can' use this
information to reduce their reliance on chemical herbicides.  The benefits of
reducing herbicide usage in corn production include cost savings to farmers;
reduced exposure to herbicides during mixing, loading,, application, and cleanup;
and  a reduced risk of ground-water  contamination  associated with  corn
production in the Central Great Plains and  Midwestern Corn Belt.
18

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 A Closing Word
 The next few years will require an
 enormous level of effort by EPA
 and our state partners  to develop
 a more comprehensive system to
 implement the provisions of the
 FIFRA '88  amendments.  The
 effort calls for equally active roles
 by a wide variety of individuals
 and groups  affected by pesticides.

 State agencies play a critical role
 in ensuring  compliance with
 regulations,  as well as in providing
 guidance to users  and educating
 the public concerning pesticide
 issues.  In the next several  years,
 states will have a new and critical
 role in ground-water protection,
 endangered-species protection,
 and farmworker safety. In  all
 areas of pesticide  regulation, EPA
 hopes to build on existing
 EPA/state partnerships.

Environmental and public interest
groups are encouraged to monitor
 the progress of particular
 pesticides through the
 reregistration process and to
 provide input  in the development
 of EPA's forthcoming regulations
on storage, transport, and disposal
of pesticides and containers.

EPA also encourages environ-
mental and public interest groups
to work closely with the public
and with pesticide users to
promote better understanding of
pesticide usage and to encourage
more integrated pest management.
Pesticide registrants will be
required to play a much more
active role in the regulatory
pro<;ess than in the past,
particularly in reregistration.
They are being asked to make
financial commitments in  the form
of fees and testing costs,  and to
meet statutory deadlines for
submitting as complete and
accurate data as possible.
Registrants will need to keep lines
of communication open with
growers about the pesticide
industry's intentions for
reregistering old products and for
registering new  products.

Pesticide users will benefit from
the increased protection that
reregistration will offer, but they
may experience temporary
disruptions in the availability of
familiar products.  Grower groups
have a role to play in:

•   Providing information to EPA
    early on about critical
    pesticide uses

•   Assisting in conducting more
    residue studies in the
    marketplace so  that exposure
    data are more realistic

•    In some cases, supporting the
    development of data for
    "minor uses" of a  pesticide for
    which the basic registrant  does
    not intend to seek
    reregistration
 •  Actively supporting and trying
    IPM and other techniques of
    sustainable agriculture to
    reduce the overall burden to
    the environment.

 The food industry should note that
 EPA's  accelerated review of older
 pesticides may uncover risk
 concerns in some cases.  Food
 industry representatives are urged
 to be as responsive as possible to
 consumer inquiries and to help in
 educating consumers on pesticide
 issues.  The food industry may
 also be asked to assist in
 improving exposure data through
 increased residue studies.

 Finally, individual members of the
public will have the opportunity to
 contribute information to the
 decisions on pesticides made by
 EPA  Ultimately the public will
 benefit from greater confidence in
 our national pesticide regulatory
 process and the enhanced safety
 of our food supply that will result
 from the implementation of
 FIFRA '88.
                                                                                                             19

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Appendices
Glossary


Active Ingredient: In any pesticide
product, the component which kills,
or otherwise controls, target pests.
Pesticides are regulated primarily on
the basis of their active ingredients.

Acute Toxicity:  The capacity of a
substance to cause a poisonous effect
(such as skin or eye irritation or
damage to an organ) or death as a
result of a single or short-term
exposure.

Cancellation:  The Federal
Insecticide, Fungicide, and
Rodenticide Act (FIFRA) section
6(b) authorizes cancellation of
registration if, when used according
to widespread and commonly
recognized practice, the pesticide
generally causes unreasonable adverse
effects on the environment, or if its
labeling or other material required to
be submitted does not comply with
FIFRA provisions.

Cholincsterase:  An enzyme that
helps regulate nerve impulses.
Cholinesterase inhibition is
associated with a variety of acute
symptoms such as nausea, vomiting,
blurred vision, stomach cramps, and
rapid heart rate, and can lead to
death in severe cases.

Chronic Toriciry: The capacity of a
substance to cause harmful health
effects after long-term exposure.

Endangered Species: Animals, birds,
fish, plants, or other living organisms
threatened with extinction by man-
made or natural changes in their
environment. Requirements  for
declaring a species endangered are
contained in the Endangered Species
Act.

Experimental Use Permit:  Pesticide
manufacturers are required to obtain
experimental use permits for testing
new pesticides or new uses of
pesticides whenever they conduct
experimental field studies to support
registration of the pesticide on 10
acres or more of land or one acre or
more of water.

Inert Ingredient:  A component of a
pesticide such as a solvent or carrier
that is not active against target pests.

Microbial Pesticide:  A
microorganism that is used to control
a pest.  Microorganisms are living
organisms so small that individually
they usually can be seen only
through a microscope.

Pest An insect, rodent, nematode,
fungus, weed, or  other  form of
terrestrial or aquatic  plant or animal
life or virus, bacteria, or
microorganism considered to be an
annoyance and which may be
injurious to health or the
environment.

Pesticide:  Substance or mixture of
substances intended for preventing,
destroying,  repelling,  or mitigating
any pest.  Also, any substance or
mixture of substances intended for
use as a plant regulator, defoliant, or
desiccant.

Reentry Interval: The  period of time
immediately following the application
of a pesticide to an area during
which unprotected workers should
not enter the area.
Registrant:  Any manufacturer or
formulator who obtains registration
for a pesticide active ingredient or
product.

Registration: Under the Federal
Insecticide, Fungicide, and
Rodenticide Act (as amended), the
formal listing with EPA of a new
pesticidal active ingredient prior to
its marketing or distribution in intra-
or inter-state commerce.

Registration Standards: Published
documents which include  summary
reviews of all the data available on a
pesticide active ingredient, data gaps
identified, and the Agency's existing
regulatory position on the pesticide.

Reregistration: The reevaluation and
relicensing of existing pesticidal
active ingredients originally
registered prior to current scientific
and regulatory standards.

Residues: The pesticide remaining
after natural or technological
processes have taken place.

Restricted Use: When a  pesticide is
registered, some or all of its uses
may be classified under FIFRA for
restricted use if the pesticide requires
special handling because of its
toxicity.  Restricted-use pesticides
may be applied only by trained,
certified applicators or those under
their direct supervision.

Suspension: EPA's act of prohibiting
the use of a pesticide in order to
prevent an imminent hazard resulting
from continued use of the pesticide.
An emergency suspension takes effect
immediately; under an ordinary
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An emergency suspension takes effect
immediately; under an ordinary
suspension, a registrant can request a
hearing before the suspension goes
into effect.

Tolerance: The maximum amount of
pesticide residue allowed by law to
remain in  or on a harvested crop.
EPA sets these levels so that the
chemicals  do not pose an
unreasonable risk to consumers.

Toxic:  Harmful to living organisms.

Toxitity:  The inherent capability of
a substance to cause adverse effects
in human, animal, or plant life.

Unreasonable Risk: Under FIFRA,
"unreasonable adverse effects on the
environment" means any
unreasonable risk to man or the
environment, taking into account the
economic,  social, and environmental
costs and benefits of the use of any
pesticide.
For Further Information:
Brochures

"Apply Pesticides Correctly: A Guide
for (Commercial Applicators," and
"Apply Pesticides Correctly: A Guide
for Private Applicators." U.S.
Depiartment of Agriculture and U.S.
Environmental Protection Agency.
Government Printing Office, 1975.

"Chemical Risk: A Primer."
Information Pamphlet.  American
Chemical Society Department of
Government Relations and Science
Policy, 1155 16th Street NW,
Washington, DC 20036.  1984.

"Citizen's Guide  to Pesticides"
(1990), " A Consumer's Guide to
Safeir Pesticide Use" (1987), "Lawn
Care for Your Home," and
"Pesticides in Drinking Water"
(1989).  U.S. EPA, Office of
Pesticide Programs (H7501C), 401 M
Street SW, Washington, DC 20460.

"Farm Chemical Safety is in Your
Hands." National Agricultural
Chemicals Association, 1155 15th St.
NW, Washington, D.C. 20005.

"Integrated Pest Management for
Turfgrass and Ornamentals." U.S.
EPA, 1989 (NTIS PB90-204587).

"The Least Toxic Pest Management
Catalog." Bio Integral Resource
Center, P.O. Box 7414, Berkeley, CA
94707.

"Pesticides: A Community Action
Guide."  Concern, Inc., 1794
Columbia Rd.  NW, Washington, DC
20009. 1987.

"Pesticide Safety for Farmworkers,"
(19&5), and "Pesticide Safety for
Non-Certified Mixers, Loaders and
Applicators" (English and Spanish,
1986). U.S. EPA, Office of Pesticide
Programs.  401 M Street SW,
Washington, DC 20460.

"Preventing Pests in Your Home";
"Lawn Care"; "Home Gardening";
"Home Garden Companion Planting";
"Pesticide Labels"; "Endangered
Species"; "EPA's Endangered Species
Protection Program." Environmental
Fact Sheets.  U.S. EPA, Office of
Pesticide Programs (H7501C), 401 M
Street SW, Washington, DC 20460.
April 1990.
Reports

Agricultural Chemicals in Ground
Water: Proposed Pesticide Strategy.
U.S. EPA, Office of Pesticides and
Toxic Substances. December  1987.

Alternative Agriculture. National
Research Council.  National
Academy Press, Washington, D.C.
1989.

Pest Management for Local
Governments. MIS Report, Vol. 21,
No. 8, International City
Management Association.

Pesticides Industry Sales and Usage.
1988 Market Estimates. U.S.  EPA.
Office of Pesticides and Toxic
Substances, 401 M St.  SW,
Washington, DC 20460. February
1990.

Pesticides in Ground Water:
Background  Document.  U.S. EPA
401 M St. SW, Washington, DC
20460. 1986.

Regulating Pesticides in Food: The
Delanev Paradox.  National Academy
of Sciences. National Academy Press,
Washington, D.C. 1987.
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Federal Register Notices
       Pesticide Contacts
U.S. EPA, Endangered Species
Protection Program; Notice of
Proposed Program.  54 FR 27984
(July 3, 1989).

U.S. EPA, FIFRA Amendments of
1988; Schedule of Implementation.
54 FR 18078 (April 26, 1989).

U.S. EPA. Inert Ingredients in
Pesticide Products; Policy Statement.
52 FR 13305 (April 22, 1987).

U.S. EPA, Worker Protection
Standards for Agricultural Pesticides;
Public Meetings and Proposed Rule.
53 FR 25970 (July 8, 1988).
EPA Headquarters
Office of Pesticide Programs
401 M Street SW
Washington, D.C. 20460
(703) 557-7102

Region 1
Chief, Pesticides and Toxic
  Substances Branch
JFK Federal Building
Boston, MA 02203
(617) 565-3932

Region 2
Chief, Pesticides and Toxic
  Substances Branch
26 Federal Plaza
New York, NY 10278
(201) 321-6765

Region 3
Chief, Pesticides and Toxic
  Substances Branch
841 Chestnut Street
Philadelphia, PA 19107
(215) 597-8598

Region 4
Chief, Pesticides and Toxic
  Substances Branch
345 Courtland Street NE
Atlanta, GA 30365
(404) 347-5201

Region 5
Chief, Pesticides and Toxic
  Substances Branch
230 South Dearborn Street
Chicago, IL 60604
(312) 886-6006
Region 6
Chief, Pesticides and Toxic
  Substances Branch
1445 Ross Avenue
Dallas, TX 75202
(214) 655-7235

Region 7
Chief, Pesticides and Toxics
  Branch
726 Minnesota Avenue
Kansas City, KS 66101
(913) 551-7400

Region 8
Director, Air and  Toxics
  Division
999 18th Street, Suite 500
Denver, CO 80202-2405
(303) 293-1438

Region 9
Chief, Pesticides and Toxics
  Branch
75 Hawthorne Street
San Francisco, CA 94105
(415) 744-1090

Region 10
Chief, Pesticides and Toxics
  Substances Branch
1200 Sixth Avenue
Seattle, WA 98101
(206) 442-1198
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 State Agency Contacts
 Rsffon 1

 Connecticut
 Director,
 Waste Engineering and Enforcement
  Division
 Bureau of Waste Management
 State Office Building
 165 Capitol Avenue
 Hartford, CT  06115
 (203) 566-5148

 Maine
 Director, Pesticides Control Board
 State House, Station 28
 Augusta, ME  04333
 (207) 289-2731

 Massachusetts
 Chief, Pesticides Bureau
 Dept. of Food and Agriculture
 100 Cambridge Street, 21st Floor
 Boston, MA  02202
 (617) 727-7712

 New Hampshire
 Supervisor, Pesticides Control
  Division
 Dept. of Agriculture
 10 Ferry Street
 Collerbox 2042
 Concord, NH  03302-2042
 (603) 271-3550

 Rhode Island
 Chief, Division of Agriculture
 Dept. of Environmental Management
 22 Hayes Street
 Providence, RI  02908
 (401) 277-2782

Vermont
Director, Agriculture  Foods and
  Markets
120 State Street
State Office Building
Montpelier, VT  05620
(802) 828-2431
 Region 2

 New Jersey
 Director, Pesticide Control Program
 New Jersey Dept. of Environmental
   Protection
 380 Scotch Road, CN 411
 Trenton, NJ 08625
 (609) 530-4123

 New York
 Director, Bureau of Pesticides
 Dept. of Environmental Conservation
 Room 404, 50 Wolf Road
 Albany, NY  12233
 (518) 474-2121

 Puerto Rico
 Director, Analysis and Registration
  of Agricultural Materials
 Puerto Rico Dept. of Agriculture
 Post  Office Box 10163
 Santurce, PR  00908
 (809) 796-1710

 Virgin Islands
 Director, Pesticide Programs
 Division of Environmental Protection
 Dept. of Planning and Natural
  Resources
 14 F  Building, 111 Watergut Homes
 Christia nsted, St. Croix
 U.S. Virgin Islands  00820
 (809) 773-0565

Regan 3

Delaware
Delaware Dept. of Agriculture
2320 South Dupont Highway
Dover, DE 19901
(302) 739-4815

District of Columbia
Dept. of Consumer and Regulatory
  Affairs
Housing and Environmental
  Regulations Administration
Environmental Control Division
2100 Martin Luther King Jr. Ave. SE
  Room 203
Washington, D.C.  20020
(202)  404-1167
 Maryland
 Chief, Pesticide Regulation Section
 Maryland Dept. of Agriculture
 50 Harry S. Truman Parkway
 Annapolis, MD 21401
 (301) 841-5710

 Pennsylvania
 Chief, Agronomic Services
 Bureau of Plant Industry
 Pennsylvania Dept. of Agriculture
 2301 N. Cameron Street
 Harrisburg, PA  17110
 (717) 787-4843

 Virginia
 Program Manager, Virginia Dept. of
  Agriculture and  Consumer Services
 Post Office Box 1163, Room 403
 Richmond, VA  23209
 (804) 786-3523

 West Virginia
 Director,  Pesticides Division
 West Virginia Dept. of Agriculture
 Charleston,  WV  25305
 (304) 348-2212

 Region 4

 Alabama
 Director, Agriculture,
 Chemistry/Plant Industry Division
 Dept. of Agriculture and Industry
 Post Office Box 3336
 Montgomery, AL  36193
 (205) 242-2656

 Florida
 Administrator, Dept. of Agriculture
  and Consumer Services
 3125  Conner Blvd., MD2
 Tallahassee, FL  32399-1650
 (904) 487-2130

 Georgia
Assistant Commissioner
 Georgia Department of Agriculture
Entomology and Pesticide Division
Capital Square, Room 550
Atlanta, GA  30334
(404) 656-4958
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Kentucky
Director, Division of Pesticides
Kentucky Dept of Agriculture
500 Mero Street, 7th Floor
Frankfort, KY  40601
(502) 564-7274

Mississippi
Director, Division of Plant Industry
Dcpt. of Agriculture and Commerce
Post Office Box 5207
Mississippi State, MS 39762
(601) 325-3390

North Carolina
Pesticide Administrator
Pesticide Section
North Carolina Dept. of Agriculture
Post Office Box 27647
Raleigh, NC 27611
(919) 733-3556

South Carolina
Department Head, Dept. of Fertilizer
  and Pesticide Control
257 Poole Agricultural Center
Clemson University
Clemson, SC  29634-0394
(803) 656-3005

Tennessee
Director, Plant Industries Division
Department of Agriculture
P.O.  Box 40627, Melrose Station
Nashville, TN  37204
(615) 360-0117

Regions

Illinois
Chief, Bureau of Plant and Apiary
  Protection
Department of Agriculture
State Fairgrounds, P.O. Box 19281
Springfield, IL 62794-9281
 (217) 785-2427

 Indiana
Pesticide Administrator
 Office of the State Chemist
 Department of Biochemistry
 Purdue University
 West Lafayette, IN  47907
 (317) 494-1587
Michigan
Director, Pesticide and Plant Pest
  Management Division
611 W. Ottawa Street
4th Floor, North Ottawa Tower
Lansing, MI 48933
(517) 373-1087

Minnesota
Director, Division of Agronomy
  Services
Department of Agriculture
90 West Plato Blvd.
St. Paul, MN  55107
(612) 297-2261

Ohio
Specialist in Charge of Pesticides
Pesticide Regulation Division
Department of Agriculture
8995 East Main Street
Reynoldsburg, OH  43068
(614) 866-6361

Wisconsin
Executive Assistant
Department of Agriculture,
  Trade, and Consumer Protection
Post Office Box 8911
Madison,  WI  53708
(608) 267-3304

Regon 6

Arkansas
Director,  Division of Feed,
  Fertilizer, and Pesticides
Arkansas State Plant Board
 1 Natural Resources Rd.
Little Rock, AR  72205
 (501) 225-1598

Louisiana
 Office of Agricultural and
  Environmental Sciences
 Louisiana Dept. of Agriculture
  and Forestry
 Post Office Box 3596
 Baton Rouge, LA  70821-3596
 (504) 925-3763
New Mexico
Chief, Division of Agricultural and
  Environmental Services
New Mexico State Dept. of
  Agriculture
Post Office Box 3150
New Mexico State University
Las Graces, NM  88003
(505) 646-2133

Oklahoma
Supervisor, Pest Management Section
Plant Industry Division
Oklahoma State Dept. of Agriculture
2800 N. Lincoln Blvd.
Oklahoma City, OK  73105
(405) 521-3864

Texas
Director, Division of Agricultural
  and Environmental Sciences
Texas Dept. of Agriculture
Post Office Box 12847
Austin, TX  78711
(512) 463-7624

Regum 7

Iowa
Supervisor, Pesticide Control
  Section
Iowa Dept. of Agriculture and Land
  Stewardship
Henry A Wallace Building
E. 9th Street and Grand Avenue
Des Moines, IA  50319
(515) 281-8590

Kansas
Director, Plant Health Division
Kansas State Board of Agriculture
901 South Kansas, 7th Ror
Topeka, KS  66612-1281
 (913) 296-2263

Missouri
Supervisor,  Bureau of Pesticide
  Control
Department of Agriculture
Post Office Box 630
Jefferson City,  MO  65102
 (314) 751-2462
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 Nebraska
 Director, Bureau of Plant Industry
 Nebraska Department of Agriculture
 301 Centennial Mall South
 Lincoln, NE 68509
 (402) 471-2341

 Region 8

 Colorado
 Supervisor, Pesticide Section
 Division of Plant Industry
 Colorado Dept. of Agriculture
 700 Kipling Street,  Suite 4000
 Lakewood, CO 80215-5894
 (303) 239-4140

 Montana
 Administrator, Montana Dept. of
  Agriculture
 Environmental Management Division
 Agriculture-Livestock Building
 Room 317, Capitol  Station
 Helena, MT  59620-0205
 (406) 444-2944

 North Dakota
 Director, Pesticides  and Noxious
  Weed Division
 Department of Agriculture
 600 East Blvd.
 Bismarck, ND 58505-0020
 (701) 224-2231

 South Dakota
 Director, Division of Regulatory
  Services
 South Dakota Dept. of Agriculture
 Anderson Building
 445 East Capitol
 Pierre, SD  57501-3188
 (605) 773-3375

 Utah
Director, Division of Plant
  Industries
Department of Agriculture
350 North Redwood Road
Salt Lake City, UT  84116
 (801) 538-7100
 Wyoming
 Manager, Technical Services
 Wyoming Dept. of Agriculture
 2219 Cairey Ave.
 Cheyenne, WY 82002
 (307) 777-7324

 Region 9

 Arizona
 Associate Director, Division of
  Agricultural Chemicals and
  Environmental Services
 Arizona Dept.  of Agriculture
 1688 Wi3st Adams Street
 Phoenix, AZ  85007
 (602) 542-3579

 California
 Assistant Director, Division of
  Pest Management, Environmental
  Protection, and Worker Safety
 California Dept. of Food and
  Agriculture
 1220 N Street,  Room A414
 Sacramento, CA  95814
 (916) 322-6315

 Hawaii
 Head, Division of Plant Industry
 Hawaii Dept. of Agriculture
 Post Office Box 22159
 Honolulu, HI 96823-2159
 (808) 548-7124

 Nevada
 Administrator, Division of Plant
  Industry
 Nevada Dept. of Agriculture
 Post Office Box 11100
 Reno, NV 89510
 (702) 789-0180

 Guam
 Director, Air and Land Programs
  Division, Guam Environmental
  Protection Agency
 Post Office Box 2999
Agana, GU  96910

American Samoa
Director, Dept.  of Agriculture
Post Office Box 366
Pago Pago, American Samoa 96799
 Trust Territory of the Pacific
   Islands
 Executive Officer, Trust Territory
 Environmental Protection Board
 Office of the High Commissioner
 Saipan, Mariana Islands  96950

 Commonwealth of Northern Mariana
   Islands
 Environmental Engineer, Division
   of Environmental Quality
 Dr. Torres Hospital
 Saipan, Mariana Island  96950

 Region 10

 Alaska
 Alaska Dept. of Environmental
   Conservation
 Post Office Box 1088
 Palmer, AK 99645
 (907) 745-3236

 Idaho
 Agrichemical Standards Bureau Chief
 Division of Agricultural Technology
 Idaho Dept. of Agriculture
 Post Office Box 790
 Boise, ID 83701
 (208) 334-3240

 Oregon
 Assistant Administrator, Plant
  Division
 Oregon Dept. of Agriculture
 635 Capitol Street, NE
 Salem, OR 97310-0110
 (503) 378-3777

 Washington
Pesticide Specialist
Washington Dept. of Agriculture
406 General Administration
  Building
Olympia, WA  98504
(206)  735-5064
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United States
Environmental Protection Agency
Of*tS?<5PP (H-7506CJCB
           DC 20460
Official Business
P0(vaHy tot Privats Use
§300
First-Class Mail
Postage and Fees Paid
EPA
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