wEPA
United States
Environmental Protection
Agency
Industrial Environmental Research
Laboratory
Cincinnati OH 45268
EPA-600/2-80-056
March 1980
Research and Development
Potentially Toxic and
Hazardous
Substances in the
Industrial Organic
Chemicals and
Organic Dyes and
Pigment Industries
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RESEARCH REPORTING SERIES
Research reports of the Office of Research and Development. U.S. Environmental
Protection Agency, have been grouped into nine series. These nine broad cate-
gories were established to facilitate further development and application of en-
vironmental technology. Elimination of traditional grouping was consciously
planned to foster technology transfer and a maximum interface in related fields.
The nine series are:
1. Environmental Health Effects Research
2. Environmental Protection Technology
3. Ecological Research
4 Environmental Monitoring
5. Socioeconomic Environmental Studies
6. Scientific and Technical Assessment Reports (STAR)
7. Interagency Energy-Environment Research and Development
8. "Special' Reports
9. Miscellaneous Reports
This report has been assigned to the ENVIRONMENTAL PROTECTION TECH-
NOLOGY series. This series describes research performed to develop and dem-
onstrate instrumentation, equipment, and methodology to repair or prevent en-
vironmental degradation from point and non-point sources of pollution. This work
provides the new or improved technology required for the control and treatment
of pollution sources to meet environmental quality standards.
This document is available to the public through the National Technical Informa-
tion Service, Springfield, Virginia 22161.
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EPA-600/2-80-056
March 1980
POTENTIALLY TOXIC AND HAZARDOUS SUBSTANCES
IN THE INDUSTRIAL ORGANIC CHEMICALS AND
ORGANIC DYES AND PIGMENTS INDUSTRIES
by
R. A. Markle, A. F. Fentiman,
T. R. Steadman, and R. A. Mayer
Battelle's Columbus Laboratories
Columbus, Ohio 43201
Contract No. 68-02-1323
Project Officer
Leo Weitzman
Organic Chemicals Products Branch
Industrial Environmental Research Laboratory
Cincinnati, Ohio 45268
INDUSTRIAL ENVIRONMENTAL RESEARCH LABORATORY
OFFICE OF RESEARCH AND DEVELOPMENT
U.S. ENVIRONMENTAL PROTECTION AGENCY
CINCINNATI, OHIO 45268
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DISCLAIMER
This report has been reviewed by the Industrial Environmental Research
Laboratory, U.S. Environmental Protection Agency, and approved for publica-
tion. Approval does not signify that the contents necessarily reflect the
views and policies of the U.S. Environmental Protection Agency,-nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
ii
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FOREWORD
When energy and material resources are extracted, processed, converted
and used, the related pollutional impacts on our environment and even on our
health often require that new and increasingly more efficient pollution con-
trol methods be used. The Industrial Environmental Research Laboratory -
Cincinnati (lERL-Ci) assists in developing and demonstrating new and improved
methodologies that will meet these needs both efficiently and economically.
This report "Potentially Toxic and Hazardous Substances in The Industrial
Organic Chemicals and Organic Dyes And Pigments Industries" is part of a con-
tinuing effort to better understand the environmental impact of these major
industrial sectors. It summarizes the results of a literature search for
toxicological information on the major chemical compounds and elements which
are the major raw materials, products and intermediates for selected chemical
processes. While this work was orginaly intended to supplement other efforts,
it can also be used as a reference of available toxicological information.
David G. Stephan
Director
Industrial Environmental Research Laboratory
Cincinnati
iii
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ABSTRACT
The objectives of this research program were the identification of
the potential hazards associated with the production and utilization
of industrial organic chemicals (IOC) and organic dyes and pigments (ODP)
and the determination of the state of the art of the technology for the
treatment and control of potentially hazardous wastes generated during
the manufacture and use of these materials. The major output of the
study consists of comprehensive master tables of 510 IOC, 142 ODP raw
materials, 722 ODP intermediates and 1458 dyes and pigments, containing
correlated compound identifications, toxicity data, chemical production
process information, waste product information, production volumes and
end use information where available.
Work done to establish definitive criteria for prioritizing the IOC
and ODP according to toxic hazard produced a substantial set of potential
criteria. However twenty "prioritized" lists that were actually produced
were based solely on the various types of toxicity data, and the production
volume data, contained in the master tables. Eight of these tables were
assembled with the chemicals ranked in order of quantitative toxicity
or production volume data and can be viewed as "priority rating" lists.
The compounds in the remaining twelve tables are presented alphabetically
and can be considered useful "priority" groups. These tables identify
some of the chemicals that pose the greatest potential hazards. However,
because the availability of specific data types on individual compounds
is limited, these tables are all incomplete compilations. For example
the most prevalent single data type, acute oral data on rats (LD50, oral-
rat), is available on about 59 percent of the IOC. The other data types
are available on 31 percent to one percent or less of the IOC, and 20
percent, or less of the ODP. Although a total of about 150 of the IOC
on these various lists appear to pose potential toxic hazards, the toxicolog-
ical data, taken from secondary compendia, were shown to range widely
in precision where replicate data were available. Consequently these
simple "prioritized" lists must be used with caution. Comparison of
eight of these "prioritized" lists with four EPA priority lists produced
45 IOC common to the two sets of priority lists of possible special signifi-
cance in terms of hazard potential. Because of the complexity of these
industries and the present state of toxicological data availability and
understanding, this study should be viewed as a beginning effort.
Assessment of the state of the art of pollution control and waste
treatment technology showed that most of the published information is
of a general nature. It was not possible to specify "best" technologies
for particular chemicals/processes given the broad scope and the time
and funding available for this study.
iv
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CONTENTS
Disclaimer ii
Foreword iii
Tables viii
Acknowledgment xi
1. Executive Summary 1
2. Introduction 7
3. Objectives 10
4. IOC and ODP Industry Comparisons 12
5. Research Approach 13
6. Master Table Compilation 15
Information Included in Master Tables 15
Name and Formula 17
Identifying Symbols 17
Toxicity Data 17
Acute Toxicity Data 17
Chronic Toxicity Data 18
Additional Background on the Toxicity Data 19
TLV 19
Compound, Process, and Waste Data 19
Total Production Volumes 19
Uses 20
Data Availability 20
Industrial Organic Chemicals 20
Organic Dyes and Pigments 21
Toxicity Data - IOC 22
Quantitative Human Toxicity Data 22
Carcinogenic, Teratogenic and Mutagenic Data 22
Quantitative Oral Toxicity 22
Quantitative Inhalation Toxicity 23
Additional Quantitative Toxicity Values 23
IOC (Table A-l) Summary 23
Toxicity Data - IOC Addendum 24
IOC Toxicity Data - Overall Summary 24
Toxicity Data - ODP 24
ODP Raw Materials and Intermediates 24
ODP Dyes and Pigments 25
ODP Toxicity Data Summary 25
Process Data 25
Waste Stream Data 25
Production Volumes 25
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7. Data Extraction Tables 27
IOC Extraction Tables 27
U.S. Occupational Standard (USDS) for Concentration in
Air-Industrial Organic Chemicals Listed Alphabetically
According to Compound (Table E-l) 27
USOS Standards Listed According to Increasing Standard
Concentrations (Table E-2) 27
Human Toxicity Data (Table E-3) 28
Carcinogens or Suspected Carcinogens (Table E-4) 28
Teratogens and Mutagens (Table E-5) 28
Oral Toxicity (LD50, Rat) (Table E-6) 29
Oral Toxicity (LD50, Animal Other Than Rat) (Table E-7). . . 30
Inhalation Toxicity (LC50) (Table E-9) 31
Mixed Toxicity Data (Table E-10) 32
Production Volume Data 32
OOP Extraction Tables 32
U.S. Occupational Standard (USOS) for Concentrations in Air—
Organic Dyes and Pigments Listed Alphabetically According
to Compound (Table G-l) 32
Human Toxicity Data—Organic Dyes and Pigments (Table G-2) . 33
Carcinogens and Suspected Carcinogens—Organic Dyes and
Pigments (Table G-3) 33
Oral Toxicity (Rat)—Organic Dyes and Pigments (Table G-4,
G-5, and G-6) 33
8. Prioritization Schemes 34
Priority or Rating Lists 34
EPA Priority Lists 35
Comparison of This Study "Priority" Lists and EPA Priority
Lists 36
Comparison of U.S. Occupational Standards (USOS) with USSR
Workplace Standards 37
Preliminary Attempts to Establish Rating Criteria 38
Toxicity Data Pitfalls 38
Data Unavailability 39
Tentative Criteria for Use in the Identification and
Priority Listing of Hazardous Industrial Organic
Chemicals 39
9. Pollution Control Technology 43
Effluent Pollution Control Technology 43
Air Pollution Control Technology 44
Incineration 46
Adsorption 47
Absorption 47
Condensation 47
Inertial Separators 47
Wet Collection Devices 47
Baghouses 48
Electrostatic Precipitators 48
Other Collection Devices 48
vi
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Page
10. Organic Dyes and Pigments Industry 50
Background 50
Industry Characteristics 50
Hazardous Substances 50
Pollution Controls 51
Emissions Controls 51
Effluent Controls 52
11. Conclusions 54
12. Recommendations 58
References 61
Appendices
A. Industrial Organic Chemicals-Toxicity Production, Waste and
Use Data 64
B. Organic Dyes and Pigments-Toxicity, Production, Waste, and Use
Data Associated with Dyes and Pigments and the Raw Materials,
Intermediates and Inorganic Chemicals Used in Dye and Pigment
Production 302
C. Key to Abbreviations and Acronyms Used in Tables in Appendices
A and B 600
D. Industrial Organic Chemicals - Possible Additions to the Master
List 602
E. Industrial Organic Chemicals - Extraction Tables Based on
Toxicity and Production Volume Data in Table A-l 609
F. EPA Priority Lists 657
G. Organic Dyes and Pigments - Extraction Tables Based on Toxicity
and Production Volume Data in Tables B-l through B-3 674
H. USSR Maximum Allowable Concentrations of Harmful Compounds in
Working-Area and Inhabited Area Atmospheres 684
vii
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TABLES
Number Page
A-l Industrial Organic Chemicals-Toxicity, Process, Waste,
Production and Use Data 64
A-2 Industrial Organic Chemicals Addenum - Toxicity 268
A-3 Industrial Organic Chemicals, Inorganics - Toxicity 290
B-l Organic Dyes and Pigments, Raw Materials - Toxicity Process,
Waste, Production and Use Data 302
B-2 Organic Dyes and Pigments, Intermediates - Toxicity Process,
Waste, Production and Use Data 308
B-3 Organic Dyes and Pigments - Toxicity Process, Waste, Production
and Data 416
B-4 Addendum to Table B-3 586
B-5 Organic Dyes and Pigments, Inorganics - Toxicity Process, Waste,
Production and Use Data 592
C-l Key to Abbreviations and Acronyms 600
D-l Radian List of Compounds to be Added to the List of Industrial
Organic Chemicals 602
D-2 Industrial Organic Chemicals Not on the IOC List or on Table
E-l - from a 1975 Petrochemical Compilation 604
D-3 1973 U.S. Tariff Commission Report Compounds Not Elsewhere
Listed 605
D-4 Additional Compounds to be considered for Inclusion in IOC
Table A-2 606
D-5 Compounds Not Already Included Which Are Covered by Effluent
Limitations Guidelines Development Documents - Organic
Chemical Industry 607
D-6 Organic Chemicals in IPPEU-IOC but with No Process Number -
Possible Additions to the IOC List 608
viii
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Number Page
E-l U.S. Occupational Standard (USOS) for Concentrations in Air-
Industrial Organic Chemicals [Listed Alphabetically According
to Compound] 609
E-2 U.S. Occupational Standard (USOS) for Concentrations in Air -
Industrial Organic Chemicals [Listed According to Increasing
Standard Concentrations]
E-3 Human Toxicity Data - Industrial Organic Chemicals 616
E-4 Carcinogens or Suspected Carcinogens - Industrial Organic
Chemicals 621
E-5 Teratogens and Mutagens 623
E-6 Oral Toxicity (LD50, Oral-Rat) Versus Production Volume, Waste
and Carcinogen Data - IOC 626
E-7 Oral Toxicity (LD50, Animal Other Than Rat Values ^ 500 mg/kg)
Versus Production Volume, Waste and Carcinogen Data - IOC . . 632
E-8 Oral Toxicity (LDLo, All Animals) Versus Production Volume,
Waste and Carcinogen Data - IOC 633
E-9 Inhalation LC50 Data Versus Carcinogen, Production, and
Emission Data 634
E-10 Toxicity Data £ 500 mg/kg or = 1000 ppm Not included in Tables
E-6 Through E-9 — Any Animal or Administration Route .... 636
E-ll Total Production - Industrial Organic Chemicals [Listed
Alphabetically According to Compound] 638
E-12 Total Production - Industrial Organic Chemicals [Listed
According to Increasing Production for 1973] 647
E-13 Industrial Organic Chemical Human and Animal Toxicity and
Carcinogen Data Added During 1979 Revision 650
F-l Effluent Guidelines Priority List (IOC - Phase 1) 657
F-2 Effluent Guidelines Priority List (IOC - Phase 2) 658
F-3 Water Quality Planning and Standards Consent Decree List . . . 659
F-4 Potentially Significant Air Toxicants From the Office of Air
Quality Planning and Standards (AQPS) 662
F-5 This Study "Priority" List IOC Distribution on EPA Priority
Lists 663
ix
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Number Page
F-6 Lists of Potentially Hazardous Waste Materials . . 665
F-7 Spills List of Potentially Hazardous Substances 670
G-l U.S. Occupational Standard (USOS) for Concentrations in Air-
Organic Dyes and Pigments 674
G-2 Human Toxicity Data - Organic Dyes and Pigments 675
G-3 Carcinogens and Suspected Carcinogens - Organic Dyes and
Pigments 676
G-4 Oral Toxicity (Rat) - Organic Dyes and Pigments, Raw
Materials 678
G-5 Oral Toxicity (Rat) - Organic Dyes and Pigments, Intermediates . 679
G-6 Oral Toxicity (Rat) - Organic Dyes and Pigments, Dyes 682
G-7 Organic Dye and Pigment - Raw Material, Human and Animal
Toxicity and Carcinogen Data Added During 1979 Revision . . . 683
H-l Comparison of United States and USSR Occupational Standards . . 684
H-2 Maximum Allowable Concentrations of Harmful Compounds in
Working-Area Atmosphere 690
H-3 Maximum Allowable Concentrations of Harmful Substances in
Atmospheric Air of Inhabited Areas - USSR 702
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ACKNOWLEDGMENTS
The authors acknowledge the valuable assistance of the following persons
in assembling this report: Dr. Paul Spaite, EPA Consultant, for many val-
uable discussions concerning the philosophy and approach to the study based
on his association with the development of the "Industrial Process Profiles
for Environmental Use" and for bringing the existence of the USSR maximum
allowable concentrations (MAC) of chemicals in working - place and inhabited
area (Appendix I) atmospheres to our attention; Dr. Philip Leber, Battelle
Staff Toxicologist, for providing guidance in selecting and analyzing the
toxicity data; Mr. Daniel Dreyer, of the Battelle staff, for translating the
article on the Russian MAC data; and Dr. Leo Weitzman, EPA Project Monitor,
for providing excellent overall guidance in carrying out the study.
xi
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SECTION 1
EXECUTIVE SUMMARY
In view of the increasing concern created by rapidly expanding industrial
production of organic chemicals, and of toxic substances and hazardous waste
legislation, the EPA has expanded studies of the organic chemicals industry.
Prior programs have usually been limited to studying relatively small
numbers of specially selected compounds or oriented toward studying broad
classes of pollutants such as BOD, COD, total hydrocarbons, etc. A need
exists for studies that will provide a comprehensive and detailed data
base covering the entire industry and the hundreds of compounds produced
by it. The present task was initiated as one effort to satisfy this
need by compiling information that would satisfy the following two objec-
tives:
(1) Identify the potential hazards associated with the
production and utilization of industrial organic
chemicals and organic dyes and pigments industries.
(2) Determine the state of the art of the technology for
the treatment and control of potentially hazardous
wastes generated during manufacture and use of these
materials.
The research followed to reach these objectives included the following:
• Literature search and assessment of literature obtained
• Compile master tables of toxicity, process, waste,
production volume and use data
• Attempt to identify definitive criteria for prioritizing
the compounds according to relative hazard
• Extract lists of compounds from the master tables
according to various specific types of toxicity
data, or production volume data. These lists can
be viewed as approximate "priority lists"
• Acquire EPA priority lists and compare with this
study "priority lists"
• Assess pollution treatment and control technology.
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In the principal effort made to reach the objectives, a data base
has been assembled that will allow ongoing analysis of the hazard posed
by the production and utilization of industrial organic chemicals (IOC)
and of organic dyes and pigments (ODP) and their raw materials and intermed-
iates. The major output of the study consists of comprehensive master
tables listing 510 IOC, 142 ODP raw materials, 722 ODP intermediates
and 1458 actual dyes and pigments. The tables contain the following
correlated information, where available:
Compound identification
Comprehensive toxicity data
Chemical production process information
Waste product information (quantitative data where available)
Production volumes
End uses (quantitative use patterns where available).
These master tables can therefore serve as convenient, single sources
of readily available, detailed information on specific compounds/processes,
or as guides to identifying and selecting groups of compounds for evaluation,
field study, effluent guidelines studies, new source performance standards
for air emissions and the like. They are also data pools useful in assem-
bling various data arrays specifically applicable to the analysis of
toxic hazard potential. As part of the present task a number of data
extraction tables were assembled, each keyed to a specific data type
in the master tables. Eighteen (18) different tables or lists of this
type were assembled based on the following types of data:
United States Occupational Standards (USOS)
Human exposure toxicity data (accidental exposure reports)
Carcinogenic data
Mutagenic and teratogenic data
Acute toxicity data
- Oral
- Inhalation
- Miscellaneous administration routes
• Production volume data.
Eight of these data extraction tables contain the chief data type arranged
in ordered fashion (for example, in decreasing level of acute toxicity
value). Additional pertinent data, such as correlated carcinogenicity,
production volume and waste product data are also included in some of
the extraction tables. Individually these tables represent "priority
rating lists" of various types that are potentially useful in assessing
toxic hazard. It is important to note, however, that the variations
in data types represented on these individual lists make it impossible
to assemble a single, master list, of "prioritized IOC".
In a separate effort EPA priority lists developed prior to and independ-
ently of the present study were identified and obtained. Six of these
lists are presented in the report, with four of them, shown below, receiving
special attention.
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(1) Effluent Guidelines Priority List - Phase I Organics
(2) Effluent Guidelines Priority List - Phase II Organics
(3) Water Quality Planning and Standards Consent Decree
List (65 Toxic Pollutants List)
(4) Potentially Significant Air Toxicants from the Office
of Air Quality Planning and Standards (OAQPS).
These four EPA lists were first compared with the master lists of IOC
and ODP developed on this study, to show the overall commonality of compound
entrants (110 common out of 128 total entrants in the four EPA tables).
This is 86 percent commonality with most of the eighteen entrants not
in the IOC master lists being in categories that fall outside the scope
of the present study (plasticizers, insecticides, etc).
Seven of this study's "priority lists" (IOC tables E-4 through E-
10, Appendix F) were then compared with the above four EPA priority lists
to determine commonality of the IOC entrants. There are 46 IOC (29 percent
of 161 candidates on the seven "priority lists") common to the four EPA
priority lists. These compounds and certain subsets of them discussed
in the report are the compounds on the EPA lists that presumably pose
toxic hazards on the basis of the readily available toxicity data. Thus
they constitute one group of the IOC that should be considered for future
EPA studies. However there are many (over 100) compounds on the "priority
lists" developed on this study (including both IOC and ODP intermediates
and dyes and pigments) which are not on the EPA priority lists but which
are equally good candidates for continued EPA investigation. These are
discussed in detail in Sections 7 and 8 in the report.
Problems inherent in the available data must be kept in mind when
attempting to use the master tables or the extraction ("priority") tables
for prioritization of compounds according to toxic hazard potential or
for selecting compounds for continued in-depth EPA studies. These relate
to data availability, data quality and prioritization criteria concerning
the following:
• List of compounds of industrial significance
• Toxicity data types and relative availability
• Production volume data
• Waste stream data
The original list of about 350 IOC upon which this study was based
has been expanded to over 500 compounds (including isomeric forms) in
the course of the study. However there are still compounds of industrial
significance not included, since it is difficult to determine with certainty
which of the thousands of known organic compounds are actually produced
commercially, when many of them are produced by only one company, frequently
for captive use, and production data are not released. The toxicity data
summary which follows pertains only to the 418 IOC included in Table A-l.
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About 88 percent of these IOC have some toxicity dava available,
and 80 percent have quantitative data. Only 6.9 percent of the ODP inter-
mediates and dyes and pigments have quantitative data. It is emphasized
that toxicity data vary widely in terms of the test protocols followed.
The consequence is that the data types and the reliabiliity of the data
produced also cover a considerable range. Thus specific toxicity data
types that can reasonably be compared for toxic hazard purposes are much
fewer in number than the overall amount of available quantitative data
indicate. The most prevalent common protocol data are oral data obtained
on rats to determine the amount of a chemical producing death within
several days to a week (acute toxicity) in 50 percent of a rat population
(LD50, oral-rat). These data are available on 59 percent of the IOC.
Other specific data types are available on 31 percent to 1 percent, or
less, of the IOC. All these data were of necessity extracted from secondary
literature sources (toxicity data compendia) which do not provide information
on the quality of the specific data. Analyses of replicated data, where
it is available, have shown that the agreement ranges from excellent
to poor (data value ratios of essentailly 1 to 50 are observed). These
data availability and data quality analyses show that the "priority"
or "rating" schemes described above, which are based on simple arrays
according to selected quantitative toxicity data types, must be used
with caution. Also they indicate the need for additional, common protocol,
toxicity testing on many compounds that already have quantitative toxicity
data.
Production volume data were obtained on about AO percent of the Table
A-l IOC, as follows:
Production Level, Number of
kg/yr (Ibs/yr) Compounds Listed
<. 4.5 x 108 (<109) 36
4.5 x 107 - 4.5 x 10S(108-109) 66
4.5 x 106 - 4.5 x 107(107-108) 52
4.5 x 105 - 4.5 x 106(106-107) 9
Thus there are at least 102 IOC with production levels of 4.5 million
kg/yr (100 million Ibs/yr) and 193 total compounds with quantitative _
production data. Most of the high volume products >_ 4.5 x 10' kg (>_ 10
Ibs) have some types of quantitative toxicity data available but the
types vary greatly, as described above. However there are also 60 percent
of the IOC (80 percent of ODP intermediates and dyes and pigments) which
have no production volume data readily available. It would be desirable
to establish whether any of these compounds are high production level
items.
The amount of the IOC or ODP escaping to the environment during produc-
tion and use is one of the most important data types bearing on determina-
tion of toxic hazard. There are quantitative data, ranging widely in
availability of specific compound information, on 28.A percent of the
IOC (none of the ODP). This includes effluent data on 3.8 percent of
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the IOC and air or emissions data on 24.6 percent of the IOC. The range
of effluent and emissions levels reflecting production factor variations
is not available. Neither is specific information on data collected
or analyses protocols. Consequently the reliability of the data cannot
be assessed at present. Furthermore there is an obvious need for obtaining
more quantitiative data, especially on more toxic compounds for which
no such data are presently available.
The attempts to establish definitive criteria for prioritizing the
IOC and ODP according to toxic hazard have so far succeeded only in producing
a substantial set of potential criteria. These are listed in the report
together with the steps taken to produce them. In the absence of a formula
that would allow quantitative, or even qualitative, evaluation of all
important criteria factors, simplistic "prioritization" or "rating" schemes,
as described above, were devised based solely on toxicity and production
volume data.
An assessment of the state of the art of pollution control technology
for handling effluents and emissions from the IOC and ODP industries
was carried out. It was determined that most of the published information
on these technologies and the processes to which they are applied is
of a general nature. These facts, plus the extremely large number of
compounds/processes involved in this study, and the very large percentage
of expenditure of available time and funds required to satisfactorily
tabulate and analyze the toxicity, process, production volume, waste
and use data, led to a decision to limit the control technology assessment
to general coverage. Summaries of the major pollution control equipment
and techniques applicable to the control of the effluents and/or emissions
from IOC production processes are presented, together with some comments
on their strengths and weaknesses. Since the applicability and efficiencies
of organic pollutant removal varies widely depending on the specific
chemical/process, it was not found possible to specify "best" technologies
on a generalized basis. Further assessment of control technologies will
be required in future studies.
The ODP industry and its special requirements for effluent treatment
are discussed in a separate section of the report. In view of the unique
situation this industry faces in controlling pollutants and because of
the rather small amount of published information this study found, three
companies producing ODP were interviewed to obtain first-hand opinions.
The concensus of these interviews, unsubstantiated by independent corrobora-
tion, is that gas and vapor emissions can be effectively controlled by
the use of commercially available absorbers, scrubbers, and filters,
while effluents (except for highly toxic heavy metals) can be controlled
by a central treatment facility. An advanced, proprietary water treatment
system now being tested in full scale operation at a plant manufacturing
disperse dyes has been described to Battelle as very promising. This
system is described in the report.
One environmental pollution problem peculiar to the ODP industry
results from the production of dyes with a significant solubility in
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water. Sodium chloride added to "salt out" or precipitate the dye product
results in effluent containing large amounts of salt and much larger
amounts of colored substances than are encountered from other dye or
pigment processes. Plants using this type of process should be located
near the ocean to avoid contamination of fresh water with salt.
The outputs of this study described above provide the EPA with a
foundation data base and a preliminary analysis of the toxic hazard poten-
tials presented by the IOC and ODP industries and their thousands of
products. However, in view of the extreme complexity of these industries
and the present state of toxicological data availability and understanding,
the study should be viewed as a beginning effort. More work needs to
be done to insure that all the important data (commercially produced
chemicals, toxicity data, production volumes, waste products data, end
use patterns, environmental stability) have been obtained. Potentially
important sources of this information which were not utilized on the
present study due to time and funding constraints include the producing
companies themselves (product brochures, annual reports, personal contacts),
industry organizations (published reports, personal contacts) and the
primary literature (computer searches of Chemical Abstracts, Index Medicus,
Predicasts, etc and retrieval of significant articles). Collection of
information by these routes would be time consuming but might provide
significant amounts of new and important data.
Considerable additional evaluation of the presently available data
is also possible. Perhaps the most valuable approach would be to expand
or modify the Radian Corporation computer data base to include the new
data from the present study. This would allow more facile compilation
and comparisons of "priority" lists. Also compilation of the various
data types keyed to specific chemical structural features would become
possible. However, even without a computer aid, further analysis of
the present data base is possible. Additional extraction table compilations
of potential value can be constructed. These could include:
• Compounds listed according to decreasing production
volume correlated with various specific toxicity data
• Compounds listed in order of toxicity data not yet
specifically analyzed (e.g., LD50, animal data obtained
by administering the chemical by routes other than
oral or inhalation)
• Compounds listed in order of total organics emissions
(quantitative data).
Of course continuation of efforts to identify the important criteria
for evaluating toxic hazard potential are certainly in order. Finally,
further assessment of control equipment and technology needs to be carried
out.
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SECTION 2
INTRODUCTION
Industrial organic chemicals (IOC) and organic dyes and pigments
(ODP) are derivative products from naturally occurring materials, largely
petroleum and natural gas, which have undergone at least one chemical
reaction such as oxidation, hydrogenation, halogenation, sulfonation,
nitration or alkylation, and which will undergo at least one additional
chemical reaction before leaving the industry, or be used in a solvent
or coloring function. The production of primary organic raw materials
by the petroleum refining industry via distillation, cracking, and reforming
operations is excluded from this study. IOC and ODP chemicals are further
identified under the 1972 Standard Industrial Classification Manual (SIC)
of the U.S. Department of Commerce. These include group 286, Industrial
Organic Chemicals subcategories Industry No. 2865, Cyclic (Coal Tar)
Crudes, and Cyclic Intermediates, Dyes, and Organic Pigments (Lakes and
Toners) and Industry No. 2869, Industrial Organic Chemicals, Not Elsewhere
Classified. However certain classes of compounds covered by these SIC
codes are excluded from consideration. These are pesticides, herbicides,
insecticides, other agricultural chemicals, Pharmaceuticals, explosives,
plasticizers, and coal tar residues and distillates other than cresols
or other chemically distinct compounds. There are also some grey areas
of compound classes such as tanning agents, rubber processing chemicals,
and flavoring and perfume chemicals which are not covered systematically,
although a few chemicals from some of these groups do appear on the master
tables.
The specific chemicals to be covered in detail in this study were
those contained in the Industrial Process Profiles for Environmental
Uses, Chapters 6 and 7. These chapters are entitled, respectively, "The
Industrial Organic Chemicals Industries" (1) and "Organic Dyes and Pigments
Industries" (15) (references are listed on page 61). Chapter 6 (March 30,
1976, draft) has undergone extensive revision since the present study was
completed in December 1976. Consequently the process description data ex-
tracted from Chapter 6 and presented in this study were revised and updated
in mid-1979.
The production of organic chemicals, as defined above, has grown
tremendously in both volume and importance, in the several decades since the
Second World War. The organic chemicals industry provides the raw materials
used by at least ten other major industries. These are (1) plastics
and resins, (2) synthetic fibers, (3) synthetic rubber, (4) solvents,
(5) plasticizers, (6) Pharmaceuticals, (7) dyes and colorants,
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(8) surfactants, (9) explosives, and (10) agricultural chemicals, including
herbicides and pesticides. As the number and tptal amount of organic
chemicals commercially produced has expanded, the type and quantities
of these chemicals escaping to the environment during manufacture and
use has increased accordingly. Emissions of volatile compounds represent
by far a greater variety of chemical types than are introduced from all
other stationary sources combined. Yet, collection of information on
which compounds are emitted in what quantity, and what sort of toxic
hazard they pose, is only beginning. Quantitative data are relatively
sparse and of uncertain accuracy. Commerical introduction of organic
chemicals into surface and groundwaters also poses great problems, but
quantitative data on specific chemicals are again sparse. It has become
increasingly clear in the past decade that many of these chemicals, either
because of inherent toxic properties, or because of the sheer volume
of their release or, in some cases, their persistance in the environment,
are hazardous.
In fact, toxic hazard crises related to this industry are occurring
with dismaying frequency. Thus a number of individual compounds (e.g.,
8-naphthylamine, DDT, dioxin, vinyl chloride, kepone, etc) have been
first exposed as potent health or environmental hazards and then subjected
to very close scrutiny, but organic chemicals as a class have only just
begun to be investigated. In the face of these facts and with comprehensive
federal toxic substances and resource conversation and recovery acts now
enacted, the EPA has recognized there exists an urgent need for well
organized and correlated baseline data and information on the range of
compounds produced. This includes the following information on these
compounds:
• identification of as complete a list of commercially
produced compounds as possible
• comprehensive toxicity data
• producing companies and plant sites
• production process details
• production volumes
• environmental loss modes and amounts
• technology to control or eliminate escape or loss
• downstream product uses (normal product fate).
Consequently the present study was contracted by the EPA as one initial
effort to meet these needs. The specific purpose of this project was
to prepare a report containing comprehensive, collated information on
portions of these need areas listed below. This report could serve as
a convenient, single source of quickly available, detailed information
on specific compounds or as a guide to identifying and selecting groups
8
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of compounds for evaluation, field study, effluent or emissions standards
studies, etc. To obtain the information needed to compile the report,
this study addressed the following subject areas:
(1) Identify potentially hazardous materials
(2) Compare the chemical products selected with various EPA
priority lists
(3) Assess the treatment and control technology of emissions
from production processes
(4) Identification of the major uses of the most hazardous
materials
(5) Provide summaries of the effectiveness of treatment and
control technologies and suggest areas in which new or
improved technology is needed.
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SECTION 3
OBJECTIVES
The overall objectives of this task study were the following:
(1) Identify the potential hazards associated with the
production and utilization of industrial organic
chemicals and organic dyes and pigments.
(2) Determine the state of the art of technology for the
treatment and control of the potentially hazardous
wastes generated during the manufacture and use of
these materials.
The general approach taken to assess the potential hazards of the
IOC and ODP industries was to conduct a computerized and hand literature
search and quickly assess the output to select appropriate documents
for use in the study. Because of the very short time period (10 weeks)
originally allotted for the entire study, only readily available secondary
literature (books, encyclopedias, monographs, readily available government
reports) were sought. Primary literature such as papers containing original
data were not sought. Then an intense data selection and organization
effort was mounted to provide collated information for evaluation as
quickly as possible. To reach the objectives the following specific
subtasks were established and carried out concurrently:
Subtask 1; Identify the sources of both industrial organic
chemicals and organic dyes and pigments included
in the Industrial Process Profiles and the wastes
associated with their production.
Subtask 2; Obtain and codify published data on the toxicity
or hazardous nature of industrial organic chemicals
and organic dyes and pigments.
Subtask 3; Propose criteria for ascertaining the relative
importance of the hazardous nature of the dif-
ferent potentially toxic and hazardous chemicals.
Subtask 4; Assess the state of the art of treatment and
control technology for both production processes
(Subtask 1) and for major uses of potentially
the most toxic and hazardous chemicals (Subtask 3).
10
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Subtask 5; Identify areas where additional data or infor-
mation is needed to satisfactorily complete
Subtasks 1 through 4.
Subtask 6; Make recommendations for research and development
on new or improved control equipment or technology.
11
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SECTION 4
IOC AND ODP INDUSTRY COMPARISONS
The two major groupings of IOC and ODP were studied and organized
into separate collated data sets. This was dictated primarily by the
fact that the basic information on each was available in separate documents
arranged according to different and basically incompatible formats.
This in turn reflects the facts that ODP production is a major and complete-
ly segregated subgroup of the organic chemicals industry dependent on
highly specialized batch processes while IOC production is, for the most
part, characterized by much higher volume continuous processes, many
of which are vapor phase and/or do not require intimate process water
contact. Most IOC products are low molecular weight, frequently liquid,
or low melting solid, compounds whereas ODP final products are relatively
high molecular weight, high melting or infusible and slightly soluble
materials. Consequently, ODP technology (processing product isolation,
product utilization) is highly specialized and the technical literature
and nomenclature are unique, requiring special background to interpret.
A major tabular compilation format (described below) was designed
which allowed both sets of compounds to be entered on the same blank forms.
Once the basic data were available in the same organized presentation,
the manipulation and study of the data was amenable to parallel interpreta-
tion. Although the extracted data sets used for analysis and prioritization
studies were kept separate for identification during use, they are very
similar. Consequently, much discussion of determination of toxic hazard
and prioritization was unified. Nevertheless, due to the above described
special nature of the ODP a brief separate discussion of this industry
is provided in a later section.
12
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SECTION 5
RESEARCH APPROACH
To meet the objectives of the study, the following methodology was
adopted:
(1) A literature search was conducted [hand and computer -
Systems Development Corporation (SDC) Off-Line Citation
List producted from National Technical Information Center
(NTIC) files].
(2) Master tables of industrial organic chemicals and
organic dyes and pigments containing correlated
toxicity, process, waste, production volume, and
use data were assembled. These central data
repositories were then used in all subsequent work.
(3) An attempt was made to identify and propose criteria
for ascertaining the relative importance of the hazard
posed by the chemicals.
(4) Various lists of data were extracted from the master
tables. Some of these lists can be viewed as "priority
lists".
(5) Various EPA toxic chemicals priority lists were acquired
or assembled and compared with the extraction lists.
(6) An assessment of treatment and control technology was
undertaken.
The literature search emphasized the identification of appropriate
major secondary data compilations which could be used to prepare the
master tables. A computer search produced 259 government reports while
about 20 standard reference works pertinent to Subtasks 2, 3, and 4 were
identified and obtained through the Battelle library facilities. The
most important and frequently used references are Items (1) through (17),
on pages 61 and 62. These references include process and compound sources
(1,9,10,12,15), toxicity compilations (2,3,4,8,16), production volume
data sources (6,9,11,12,14), and information on uses (4,7,13,17).
The compilation and processing of the master tables, which are presented
in Appendices A and B, turned out to be a massive undertaking which required
a major portion of the effort. However, the output of this effort represents
13
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what is believed to be a valuable and unique set of information never
before assembled in such a fashion. These tables are discussed in detail
in the next section. They are central repositories of correlated data
that serve as the main output and focal point of the study.
The effort to identify and establish criteria for priority rating
industrial organic chemicals and organic dyes and pigments proved to
be a very difficult and challenging task. Suggested criteria and approaches
for using them are listed and discussed but no formal approach adopted
as yet. This work is discussed in Section 8, starting on page 38.
In the absence of solid, detailed criteria for identifying hazardous
materials at the present time lists of chemicals based on various types
of toxicity data or production volumes were extracted from the master
tables. Mostly these are based on raw toxicity data arranged in numerical
sequences of decreasing toxicity. Some of these extraction lists are
correlated with quantitative waste data and production volumes. These
lists can be handled as "priority" lists for the present, although their
use must be undertaken with considerable care, keeping in mind the simplis-
tic approach with which they were assembled.
Nonetheless, these "priority" lists of IOC and ODP can be compared
with various EPA priority lists that were obtained or assembled. In
this way different lists or methods of ranking IOC and ODP for potential
hazard can be compared to determine degree of commonalility and to aid
in selecting highest priority compounds/processes for further study.
Literature pertaining to treatment and control technology was also
obtained. Evaluation and compilation of this information has allowed
summaries of the state of the art in effluent and emissions control to
be assembled. The applicability of these controls to specific processes
is, however, beyond the scope of this present project. Also three industry
contacts were made concerning orgnic dyes and pigments, since relatively
little published information is available on pollution control in this
special segment of the chemical industry. Some very interesting information,
presented in the discussion of ODP (page 51), was obtained during these
contacts.
In summary, an initial assessment of the information and data pertinent
to the potential hazards posed by the production of IOC and ODP by industry
can be accomplished by the results described in the following sections.
However, in view of the breadth and complexity of this industry and the
present state of toxicological data availability and understanding the
study must be viewed as a_ beginning effort which has not yet probed the
subject in depth with the funds and time allotted.
14
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SECTION 6
MASTER TABLE COMPILATION
Master tables of toxicity, process, waste products, production volume,
and end use data (Appendices A and B) were assembled. The main lists
of organic compounds and organic dyes and pigments that are included
were taken from the Industrial Process Profiles for Environmental Use,
Chapter 6, The "Industrial Organic Chemicals Industry" (1) and Chapter 7,
"Organic Dyes and Pigments Industries", (15). These EPA compilations
of industrial chemical process information, which were draft documents
being edited by Radian Corporation, Austin, Texas, when the present study
was carried out in 1976, were chosen as the basis for this study, since
they were the most recent comprehensive compilations of process and end
use data available when this quick response task was started. The compre-
hensive toxicity data presented were taken from the major available compen-
diums (references 2, 3, 4, and 8). These master tables now comprise
basic tools for addressing the major task of assessing the toxic hazard
posed by the production and use of industrial organic chemicals (IOC)
and organic dyes and pigments (ODP). Once the degree of toxic hazard
posed by the products and their associated waste streams (emissions,
effluents, sludges, and solids) has been established, an assessment of
applicable waste and pollution control technology will be possible.
INFORMATION INCLUDED IN MASTER TABLES
The tables are arranged as facing page (two page) layouts which present,
on the left hand page the following information:
• Name and formula (where applicable) of IOC or ODP, with
selected cross-references supplied
• Chemical Abstract Registry number and Wiswesser Line
Notation (WLN) identifying symbols
• Oral toxicity data - LD50 refers to the dose that produces
death in 50 percent of the exposed animal population.
Any value -500 can be considered a potential toxic
hazard. Also LDLo (Lowest lethal dose) data are listed here.
• Toxicology - includes all toxicity data other than
oral LD50 and LDLo, and carcinogenic data. Thus
all other administration routes (skin, inhalation,
etc) are presented here. Definitions of exposure
mode acronyms are in Appendix C. Also listed there
15
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are summary narrative descriptions of human or
animal physiological symptoms or malfunctions.
• Threshhold limit value (TLV) - includes current
and selected recommended U.S. occupational standards
• Carcinogenic data
On the right hand page of the tables are presented the following:
• Sources of products (raw materials, catalysts,
solvents)/Process Type (ammonolysis, oxidation,
etc)
• Process number from references 1 or 15
• Waste stream information (quantitative data when
available - emissions factor units are Ibs/ton,
as originally reported)
• Waste treatment used in present process (when available)
• Total production of IOC and dye raw materials or
intermediates in millions of kilograms/year;
ODP in thousands of kg/year
• Uses of compound, especially downstream syntheses
or manufacture of new organic chemicals, polymers,
etc (quantitative use patterns presented where
available)
• References
The information contained in the master tables, as outlined above, is
described in greater detail in the following sections.
Name and Formula
The name under which the compound is listed in references 1 and 15
is listed first for both IOC and ODP. IOC are then further identified
in most cases with an alternative descriptive name and molecular and
empirical formulas.
Identifying Symbols
The Chemical Abstract (CA) registry number and Wiswesser Line Notation
(WLN) are listed for most of the compounds. The CA number is a unique
identifier in the American Chemical Societies' Chemical Abstracts index
system. It provides a search key if future literature searches for informa-
tion on specific compounds are needed.
16
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WLN symbols were taken from (2, 1975 Ed.)» or determined, as needed.
They express chemical compound structures as a linear string of symbols.
The resulting notation is compact and unique for each compound. It is
particularly suitable for computer processing, especially for sorting
compounds on the basis of selected functional group or structural features
such as amino, chloro, benzene rings, etc, or combinations of features.
Thus computer storage of compound and process data, keyed to WLN symbols,
will allow facile recall and display of toxicity data (and other data)
for compounds or sets of compounds. Eventually computer storage should
provide a tool for helping to develop criteria for rating toxic hazard.
Once such rating criteria are established computer processing can be
expected to aid in prioritizing compounds/processes for various purposes
relative to potential hazard.
Toxicity Data
Toxicity information presented, as outlined above, includes various
acute and chronic quantitative test data, together with qualitative hazard
ratings and narrative summaries of physiological symptoms and malfunctions.
Almost all of the quantitative data were obtained by administering the
test compound to a group of animals using a particular exposure route,
although a few quantitative human data, based on accidental exposures
are also listed.
Acute Toxicity Data—
The most readily and frequently obtained toxicity data are acute
data obtained by single dose administration followed by observation of
the animals for several hours to 1 week. Symptoms and death or death
rate are commonly the data recorded. Proper determination of LD50 data
is accomplished by delivering different quantities of the test compound
to various groups of animals and statistically determining the dose produc-
ing 50 percent deaths. Lethality estimates other than 50 percent, e.g.,
1 percent, LD1 or 99 percent, LD99 can also be determined. Lowest lethal
doses (LDLo) are also obtained using these test procedures. Inhalation
tests to determine LC50 values are similar except the experiment must
involve a finite exposure time (preferably 4 hours) in addition to controlled
air concentrations of the test compound. Results of acute tests on differ-
ent species can show the spread of biological variation and reveal, for
example, the major organs or systems involved, assuming of course that
the data have been obtained under conditions that allow valid comparisons.
A problem inherent in the toxicity data compilation in the master tables
is that the data are extracted from secondary compilations. Consequently
direct assessment of the precision or accuracy of the data is not possible.
Acute toxicity test data, especially LD50 values obtained by the
same administration route (equivalent test protocols), can normally be
considered comparable for at least first approximation rating purposes.
This is done and extraction (rating) tables are discussed in Sections
7 and 8. Even LD50 data obtained using different animals but the same
administration route are generally usable for at least order of magnitude
comparisons. This can be seen, for example, by scanning the LD50, oral
17
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test data in Tables A-l, A-2, B-l and B-2. There are exceptions, of
course, and some of these are summarized later, on pp 30 and 31.
A useful toxicity comparison scale for this study (cf references 2,
1975 Ed., page xviii and 16, page 19) is the following:
Acute LD50 Value Scale
^1 mg/kg poisons
1 to 50 mg/kg highly toxic
50 to 100 mg/kg very toxic
100 to 500 mg/kg moderately toxic
0.5 to 5 gin/kg slightly toxic
>5 gin/kg essentially nontoxic.
A similar arbitrary LC50 scale (inhalation data) can be constructed by
considering 2 ppm (~ 0.4 mg/m^) inhalation exposure as equivalent to
1 mg/kg on the LD50 scale. On this basis, an oral LD50 of 500 mg/kg
would be considered equivalent to an LC50 of 1000 ppm (or ~ 200 mg/nr)
inhalation exposure (preferably 4 hour exposure). This arbitrary rating
scale will be used as the basis of identifying categories of toxicity
in subsequent discussions in this report.
Chronic Toxicity Data—
Quantitative chronic test data presented in the tables include carcino-
genic, teratogenic and mutagenic data. These data types are obtained
by studying the effect of repeated administration of the compound over
varying periods of time, usually months or 1 or more years. Of necessity
this type of test covers an appreciable span of the typical animals lifetime
and requires careful test design, including control groups. All animals
must be subjected to pathological examination. Data recorded under carcino-
gen include both true carcinogens, i.e., cellular tumors which are normally
fatal or are associated with the formation of secondary tumors (metastasis),
and neoplasms, i.e., all other tumors. These data represent an extreme
range of test conditions, i.e., animal type/dose administration route/expo-
sure mode and time. Thus ranking carcinogenic data for comparison purposes
is very difficult, even though it is clear that some compounds are appre-
ciably more potent carcinogens than others. An unordered list of compounds
producing carcinogens or neoplasms (as determined by testing on animals)
will be presented later. Teratogenic (nonhereditary birth defects) and
mutagenic (permanent genetic changes) effects data are the other quantitative
chronic data listed. Chronic effects such as irreversible renal, hepatic,
heart, central nervous system, etc, damage produced by long term exposure
are covered by the narrative summary discussions under the toxicology
heading. Reference 3 (Sections 9 and 12) should be referred to for a
fuller explanation of this information and more complete data where desired.
Additional Background on the Toxicity Data—
It is necessary to refer to the abbreviations and acronyms list (Appen-
dix C) in order to decipher the toxicity entries in the tables. A more
thorough discussion of the subtleties and intricacies of toxicological
testing and the nature of toxicity data are beyond the scope of this
18
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study. However these factors should ultimately be considered in determining
toxic hazard priorities. For a more complete description of this subject
the reader is referred to (2,3), especially to the criteria section in
(2) and Sections 9 and 12 in (3), and to reference 16, chapters 2-5, 10,
and 13 in particular.
TLV
Threshold limit values were established originally by the American
Conference of Government Industrial Hygienists. They were adopted by
OSHA in 1971 as official occupational workplace standards (U.S.O.S. or
United States Occupational Standards). TLV's were established on the
basis of the best available information from industrial experience and
from experimental human and animal studies. They are not intended as
a relative index of hazard or toxicity. However these standards do indicate
the level of concern they engender as individual compounds on the basis
of workplace experience and experimental toxicity data.
Compound, Process, and Waste Data
These entries are summarized adequately in the outline. Information
in these columns found in Tables A-l through A-3 and B-l through B-4
was taken from refences 1 and 15. Additional data on wastes (emissions
factors) was derived from reference 12. Since reference 1 has since under-
gone extensive editing and revision by Radian Corporation and the Environ-
mental Protection Agency it was necessary to change some of the entries
under these headings in 1979. This is particularly true of the process
numbers. Quantitative waste stream data taken from reference 1 (Air;
and Water; data) are presented in the original units. The emissions
factors units are Ibs of emitted chemical per ton of product.
Total Production Volumes
Production data are for total product, summed for all processes,
taken from references 6, 9, 10, 11, 12, and 14. They are 10" kg/year,
IOC and ODP-raw materials and intermediates, and 10^ kg/year, OOP-dyes
and pigments.
Uses
Qualitative use data are adapted from reference 1 while quantitative
use patterns are from reference 13. The quantitative use data in reference
13 were compiled from references 6 and 17.
DATA AVAILABILITY
Industrial Organic Chemicals
As described earlier, the basic list of IOC used in compiling Table
A-l was taken from reference 1. Table A-l contains an extensive listing
of the IOC (418 numbered items). These include 353 different basic organic
chemicals, plus 65 isomeric forms. However as the compilation of Table
19
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A-l proceeded it became apparent that not all organic chemicals that should
be included in this study were in reference 1. . Since this determination was
made about 170 additional compounds have been identified from various
sources (Tables D-l through D-6, Appendix D; and Tables F-l and F-2, Appendix
G) that are considered potential candidates for inclusion as IOC. These
tabulated sources of the 170 additional compounds include the following:
(1) Table D-l. Radian Company List of Compounds to be Added to the
List of Industrial Organic Chemicals
(2) Table D-2. Industrial Organic Chemicals Not on the IOC
List or on Table D-l - from a 1975 Petro-
chemical Compilation(a)
(a) Hydrocarbon Processing
(3) Table D-3. 1973 U.S. Tariff Commission Report Compounds
Not Elsewhere Listed
(4) Table D-4. Additional Compounds to be Considered for
Inclusion in IOC Table A-l
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Inorganic chemicals associated with the production of the IOC of Table
A-l are listed in Table A-3 for information purposes. Many of these conr-
pounds are quite toxic and may sometimes be found in waste streams from IOC
production. The consideration of these inorganic chemicals is outside the
scope of this study but they may need consideration in follow-on studies.
Organic Dyes and Pigments
The ODP master tables include raw materials (Table B-l), intermediates
(Table B-2), and dyes and pigments (Table B-3) taken from reference 15.
There are 32 raw materials used in ODP production listed in Table B-l.
Three of these compounds (item numbers 11, 26, and 31) are also listed in
Table A-l. In addition, 113 compounds listed in Table A-l are marked DP,
indicating that these are also dye and pigment raw materials. Thus, there
are a total of 142 ODP raw materials included in these two tables. ODP
intermediates (764 items) are listed in Table B-2. However, 42 of the
numerical sequence of listed items are actually cross-reference indicators,
so that the number of unique compounds listed is 722. In addition, 26 of
these are also in Table A-l, so that the number of new compounds is actually
696. ODP are found in Table B-3 (1458 items) and Table B-3 Addendum (30
items). However, ODP in the addendum table are only modifications (e.g.,
food dye forms) of the ODP in Table B-3.
Essentially the same data was obtained on these items as for IOC. The
major differences were that appreciably less toxicity and production data
were found but that many more compounds had to be searched to obtain these
data. Some qualitative but no quantitative waste data were available. No
attempt was made to identify end uses for specific ODP. Inorganic chemicals
associated with ODP production are listed in Table B-4, along with inorganics
in Table A-3 marked DP. The same comments apply to these inorganic chemi-
cals as were made earlier for IOC-associated inorganics.
Toxicity Data - IOC
A brief summary of the various tabulated toxicity data is provided here
to show the extent of available data. These data are tabulated in various e
extraction tables discussed below and also in Section 6 - Data Extraction
Tables (cf Appendix E) . The data are extracted from Appendix A, Table A-l.
Quantitative Human Toxicity Data—
Human toxicity data are available on 126 compounds (30 percent of IOC).
These data are listed in Tables E-3 and E-13. Examination of these tables
shows 98 reported deaths resulting from exposure to specific compounds.
However, 67 of these data are toxic hazard scale estimates derived from
reference 39 (as listed in reference 2, 1977 edition), rather than actual
lethality data. Thus 31 of the deaths listed in Tables E-3 and E-13 are
based on actual reported death incidents, while the remaining 67 are
apparently estimates based on animal test data. These 67 data are taken
from a toxic hazard rating scale, e.g., 5-50 mg/kg, extremely toxic. Hence
they are always in units of 5, 50, 500 or 5000 mg/kg.
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Carcinogenic, Teratogenic and Mutagenic Data—
Carcinogenic or neoplastic effects have been observed on 63 (15 percent)
of the IOC (Tables E-4 and E-13). Of these, six are recognized human carcino-
gens, two others are suspected human carcinogens and at least 14 are potent
animal carcinogens. A potent carcinogen is arbitrarily defined here as any
recognized human carcinogen or any animal carcinogen or neoplasam response
from any exposure <_ 1 gm/kg body weight by any route over any time period.
Also 12 compounds (3 percent) are teratogens or mutagens, with 7 of
these (58 percent) also carcinogens (Table E-5). Five of these items (IOC
numbers 86, 101, 187, 204, and 286) were added during the 1979 revision.
There are also 6 IOC-Addendum (Table A-2) compounds listed because of the
importance of this data type. • Included with these are 2 new additions
(IOC-ADD 42 and 65) since 1976.
Quantitative Oral Toxicity—
The master table of IOC (Table A-2) contains 418 number compound list-
ings. These include 353 different basic organic chemicals, plus 65 isomeric
forms. There are 326 (78 percent) of these compounds with quantitative oral
toxicity data of widely varying types. However, the most prevalent toxicity
data that can be fairly compared for evaluating relative toxic hazard is
LD50, oral-rat. These data are available on 245 (59 percent) of the 418
compounds (Table E-6). Of these data, 64 values (26 percent of 245, 15
percent of 418) are - 500 mg/kg. These compounds are given ordinal ratings
as a function of decreasing toxicity in Table E-6.
Also 130 compounds (31 percent of 418) have LD50, oral-animal other
than rat. Of these data, 107 are on compounds that also have LD50, oral-
rat data, i.e., they are overlap data. However 23 (5.5 percent of 418) of
these data are on compounds that do not have LD50, oral-rat data, with 2 of
these (0.15 percent of 418) values ^ 500 mg/kg (cf Table E-7, rating no's 1
and 6). Also listed in Table E-7 are an additional 14 compounds with LD50,
oral-animal other than rat toxicity data = 500 mg/kg. These are compounds
which have LD50, oral-rat data > 500 mg/kg. Thus a total of 276 (66 percent)
of the 418 IOC compounds have some other type of LD50, oral data, with 87
(21 percent) showing some values = 500 mg/kg.
There are also 95 compounds with LDLo, oral-any animal data. Sixteen
(16 or 1.2 percent of 418) of these compounds (Table E-8) have LDLo, oral
^ 500 mg/kg, but do not have LD50, oral-rat data at this toxicity level.
Summarizing to this point, oral toxicity data values = 500 mg/kg are
available as follows:
LD50, oral rat 64 compounds
LD50, oral-animal other than rat 2 compounds
LDLo, oral-animal other than rat 16 compounds.
Thus at least 82 (20 percent) of the IOC have acute oral toxicity data that
indicate they may represent toxic hazards.
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Quantitative Inhalation Toxicity—
There are quantitative inhalation toxicity data on 116 (28 percent) of
the 418 IOC. Thirty-one (31, 7.4 percent) of these are LC50 data, while the
rest are LCLo or TCLo data. The LC50 data (Table E-9) include about 18 com-
pounds (4.3 percent of 418) showing lethality at _< 1000 ppm or <_ 200 mg/m3
(arbitrary scale), (variable animal and exposure time). About 11 (2.6 per-
cent) of these compounds show lethality at the 500 ppm or lower level. The
rating order shown must be considered approximate in view of the variations
in the tests and results (animals, exposure time, units).
Additional Quantitative Toxicity Values—
A number of remaining toxicity data, varying widely in terms of animal,
chemical administration path and exposure mode/time are grouped together in
Table E-10. Only those data ^ 500 mg/kg or 1000 ppm are included and the
data are arranged alphabetically according to compound. There are 59 items
listed in unordered fashion due to the wide variation in the data types. An
additional 15 compounds added to this list during the 1979 update are in
Table E-13. Thus a total of 74 (18 percent) are in this category. Some of
these compounds have LD50, orl-rat _< 500 mg/kg.
IOC (Table A-l) Summary—
About 88 percent of the 418 IOC have some toxicity data (quantitative)
or information (qualitative) presented. About 80 percent have quantitative
data while the remaining 20 percent have only qualitative information.
However, it must be emphasized that, in spite of the rather numerous quanti-
tative data presented, by far the most prevalent data obtained under con-
ditions that permit reasonably valid data comparisons are LD50, oral-rat.
These data exist on only 59 percent of the IOC. Also most of the compounds
that do not have LD50, oral-rat data have no common data base, since the
other LD50 data, the LC50 data, the LDLo and LCLo data are each available
on only about 31 percent, or less, of the IOC and were obtained using a wide
range of animals and exposure modes. Thus there is only moderate to slight
internal consistency in these data. Overall the available data may be
summarized as follows:
Percent of
Compound category or toxicity type IOC
Toxicity information of any type 88
Quantitative toxicity data—all types 80
Oral toxicity data—all types 78
LD50, oral—all animals 64
LD50, oral-rat 59
Inhalation toxicity data—all types 28
Carcinogenic or neoplasam data—all types 15
LC50, ihl—all animals 6
LC50, ihl-rat 4
Mutagenic or teratogenie data—all types 3
There are sufficient toxicity data available to provide a basis for deter-
minating the relative hazard potential of most of the high volume IOC. Con-
sequently, the task of selecting candidate products/processes for such
purposes as new source performance standards evaluations can go forward.
23
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However there are serious gaps in the toxicity data base, as demonstrated
above, and searches for additional data and identification of compounds
requiring additional experimental toxicity evaluation should be instituted.
Toxicity Data - IOC Addendum
There are 92 additional IOC compounds recommended for addition to the
master IOC list in Table A-2, together with the readily available toxicity
data. These IOC compounds show a similar breakdown of available toxicity
data. Inspection of this table (there are no extraction tables) shows LD50,
oral-rat available on 57 compounds (62 percent). Six more compounds (6 per-
cent) have other LD50 data or LC50 data. Of these data 15 LD50, oral-rat
values (16 percent) are = 500 mg/kg and 7 (7.4 percent) other LD50 and LC50
values = 500 mg/kg or = 1000 ppm are available. Thus 63 compounds in this
table (68 percent) have LD50 or LC50 toxicity data with at least 22 of these
data (23.9 percent) indicative of potential hazards. Seventeen compounds
(18 percent) have carcinogenic data, with about 10 (10.9 percent) of these
showing potent carcinogenic potential. There are also 5 compounds with
teratogenic or mutagenic data, with one of these also a carcinogen. Thus the
data are similar in availability to master Table A-l.
IOC Toxicity Data - Overall Summary
To summarize, the combined IOC data compilations show that a good amount
of toxicity data is available. About 88 percent of all IOC covered have
some type of toxicity data. These data should prove very useful in rating
the potential hazard of IOC when analyzed together with other factors such
as production volumes, losses to the environment during production (waste
stream factors), significant use patterns, and other factors such as
physical and chemical properties and environmental stability.
Some serious gaps are identified in the toxicity data base. For
example, the data presented identify a number of compounds that are candi-
dates for LD50, oral-rat testing, in order to provide a more complete common
data base. Also volatile compounds that do not presently have LC50 data
and numerous compounds that do not have carcinogenic test data but might be
anticipated to show carcinogenic potential are present. These data gaps can
be filled in one of two ways. Searches of the primary literature can be
done to obtain data not yet added to the secondary compendiums used as
data sources in the present study. The data gaps still remaining should then
be filled by additional toxicological testing. Compounds to be tested and
toxicity data to be sought should be selected only after careful analysis of
the updated data base.
Toxicity Data - PDF (Appendix H)
ODP Raw Materials and Intermediates—
There are LD50, oral-rat data on 10 of 31 (32 percent) ODP raw materials
(Table G-4), with 5 of the values (16 percent) = 500 mg/kg. Only 48 (6.5
percent) of the 722 intermediates have LD50 oral-rat data with 15 (2 percent)
^ 500 mg/kg (Table G-5). There are 7 dyes (Table G-5) with ID50 oral-rat
24
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data, none of which is below 500 mg/kg. The total list of raw materials and
intermediates (753 compounds) has 13 human toxicity exposure data (2 lethal)
(Table G-2) and 45 carcinogenic data entries (Table G-3). There are 6 recog-
nized human carcinogens in the intermediates table, and several more compounds
with potential carcinogenic animal test data that suggest that these compounds
should be scrutinized more closely. There are no inhalation data presented
on these compounds. Table G-7 contains 4 human and 4 animal 1979 data.
OOP - Dyes and Pigments—
There are 22 (1.5 percent of 1458) dyes and pigments with carcinogenic
data (Table G-3). About 6 of these appear to be potent carcinogens in
animal tests. Only 7 dyes and pigments have oral toxicity data. One dye
has human lethality data (Table G-2) available. No inhalation toxicity data
were found.
ODP Toxicity Data Summary—
Toxicity data are available on 150 ODP intermediates and dyes and pig-
ments, with most of the data on intermediates. This is only 6.9 percent of
the total of 2180 intermediates and dyes and pigments. Hence far fewer
toxicity data are available on this class of products, then on the IOC.
Process Data
Reference 1 and 15 were relied on for production process data, since
these prior EPA studies had attempted to obtain this information in detail.
The Radian Organic Chemical Producers Data Base Program (Reference 12)
updated this information on IOC. As additional process information becomes
available, it should be incorporated into updated versions of the present
report.
Waste Stream Data
Quantitative waste stream data, which includes data on 1 or more
specific compounds in each case, are available on 119 of the IOC (28.4 per-
cent of 418). This includes water effluent data on 16 compounds and air
emissions data on 18 compounds from Reference 1 and emissions factor data
on 85 compounds from Reference 12. These data vary widely in availability
of specific compound information. The range of effluent and emissions
levels relative to industrial production over appreciable time periods is
not available. Neither is information on how the data were collected or how
the calculations were made. Consequently the validity and accuracy of the
data are not known. Only a small amount of qualitative information is
available on ODP products.
Production Volumes
Production volume data were obtained from the best available sources.
Data are available on 163 (39 percent) of the IOC compounds in Table A-l.
They are also presented on 27 (29 percent) of the 93 compounds in IOC
addendum Table A-2. Production data presented cover years ranging from
1968 through 1978, with most data for 1973 (124 items, 39 percent). 1973
is considered the best recent base year for comparing compounds on the
25
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basis of relative production levels, since it represents data prior to the
major perturbations resulting from the oil embargo and subsequent raw
materials and energy shortages, and the effects of the 1974 economic
recession. Data for the 50 highest volume compounds in 1978 (10, June 11,
1979) are also included in Tables A-l and A-2.
ODP production volumes are available on 23 (3 percent) of 722 inter-
mediates (Table B-2) and 273 (19 percent) of 1458 dyes and pigments (Table
B-3).
The major source of production volume data is the U.S. Tariff Commission
(9,10). This government agency collects statistical data on industrial pro-
duction directly from the companies. However, quantitative data are only
published if there are 3 or more producing companies. This is done to pro-
tect the confidentially of the data when only 1 or 2 producers are involved.
Hence, these data are in the USTC files but are unavailable for public
disclosure. All other published data ultimately are derived from figures
released for publication by. the producing companies or from data estimates
based on known industrial capacities and general production levels.
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SECTION 7
DATA EXTRACTION TABLES
The master tables (Tables A-l, A-2, A-3, B-l, B-2, B-3, and B-4)
are thorough compilations of correlated data and information. They can
be used as convenient references for many types of data on IOC or ODP
compounds or processes. However, the information contained in these
master compilations can be put to use much more effectively or efficiently
if various types of data or information are extracted and presented in
more compact correlations. A number of these more readily usable data
extractions have been identified and compiled for use on this task study.
No doubt additional combinations or ways of correlating or presenting
the data can, and will be, devised. Most of the extraction tables have
already been referred to and some of the contents discussed in Section
6, since they were convenient sources of data on the range of data availabi-
lity. Thus their contents and meanings have already been discussed to
some extent. There are two sets of extraction tables presented, those
on the IOC in Appendix E and those on the ODP in Appendix G. There are
13 IOC extraction tables (Tables E-l through E-13) and 7 ODP extractions
tables (Tables G-l through G-7). These tables, what is in them and the
reasons for their compilation are described below.
IOC EXTRACTION TABLES
The 13 tables are given in sequence, followed by a brief description
of their contents and usefulness.
U.S. Occupational Standard (USOS) for
Concentrations in Air-Industrial Organic Chemicals
Listed Alphabetically According to Compound (Table E-l)
The USOS are workplace standards developed from industrial experience
and experimental animal studies. They are not intended as relative indices
of hazard or toxicity but they do indicate a level of concern engendered
on the basis of human experience. The list of compounds represents commercial
compounds that have come into question in the past and should therefore
include many of the IOC or ODP that are potential health hazards.
USOS Standards Listed According to
Increasing Standard Concentrations (Table E-2)
Experience has presumably resulted in accidental exposures, or
testing has produced data, on which of the USOS compounds pose the greatest
health threat. Thus listing them with the lowest exposure level compounds
first provides one approach to identifying compounds that should be looked
at very closely across their spectrum of properties.
27
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Human Toxicity Data (Tables E-3 and E-13)
Accidental human exposure data of four types are listed: LDLo,
LCLo, TDLo, and TCLo. The exposure mode and toxic effect are noted, with
the quantitative exposure data. Of particular note are at least 31 cases
of death noted after exposure to various of the chemicals (LDLo and LCLo).
It seems reasonable to subject those compounds which have caused human
death, especially at low or moderately low exposure concentrations (cf
Table E-3), to closer scrutiny. Of lesser note but still important are
the IOC which have produced toxic effects but not death. Again, the
compounds producing measurable effects at the lowest doses or concentra-
tions should be the greatest cause for concern. Since the modes of exposure
and the resultant exposure levels have varied so widely no attempt has
been made to order the compounds in terms of relative hazard potential.
This list of compounds can be compared with the other lists to be described
below, for commonality of entrants.
Carcinogens or Suspected Carcinogens (Tables E-4 and E-13)
Chemicals which produce tumors (cancerous growths or neoplasms) are
of particular concern today to the average person. This is true even
though acute or chronic health conditions of other types may also be likely
to occur to the average citizen.
In view of this special interest, carcinogens have been listed separately
in the master tables and have been extracted into Tables E-4 and E-13.
The TCLo quantitative data, administration mode/animal, and toxic effect
noted are listed. As in the case of human exposure data, the modes of
test and resultant data units are so variable that no attempt was made
to present the compounds in order of decreasing toxic effect. It is not
possible on the basis of the present study to determine which compounds
pose the greatest toxic hazard, beyond those compounds already labeled
as known human carcinogens. Each of these compounds should be viewed
as candidates for further study and for comparison with the other lists
for commonality.
Teratogens and Mutagens (Tables E-5 and E-13)
Eleven (11) compounds with animal test data indicating that they
are teratogens and 1 with data implicating it as a mutagen, are listed
in Tables E-5 and E-13. It is of interest that 5 of the 11 compounds
with teratogenic data, also have been implicated as potent carcinogens.
When this is coupled with carcinogenic potential, these compounds are
of high toxic hazard potential and should be included in any list of com-
pounds to receive further, close study.
There are also 4 teratogens and 1 mutagen in this table from the
IOC Addendum list (Table A-2), and 3 dyes that have shown potent teratogenic
characteristics in animal tests. Two of these are also animal carcinogens.
All categories of chemicals (IOC, ODP) covered by this study were
included in this table because of the small total number of compounds
involved. These compounds should also be compared with the other lists
of toxic data to determine commonality.
28
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Oral Toxicity (LD50. Rat) (Table E-6)
As described earlier this is by far the most prevalent toxicity data
that can be fairly compared for ranking purposes. There are data on 59 per-
cent of the IOC, with at least one-fourth (15 percent of the IOC) at an
LD50 level (- 500 mg/kg) that can be considered a potential hazard level.
These data are arranged in order of increasing LD50. Of course, lowest
LD50 equates with highest toxicity.
Any data on carcinogenicity (Tables E-4 and E-13) and teratogencity
or mutagenicity (Tables E-5 and E-13) are also cross-listed in Table E-6.
Production volumes and the existence of quantitative waste stream data
(Table A-l) are also listed. Thus, this table is one of the most important
extraction tables, containing four types of correlated information that
bear on determining whether compounds pose a potential hazard and "prioriti-
zing" the relative degree of hazard posed. The existence of commonality,
whether it is 2, 3 or all 4 data types, and the ranking of each data type
(LD50, carcinogenic potential, production volume, quantitative loss patterns),
are all of obvious importance in determining which compounds/processes
are most hazardous. However, a method of weighting (prioritization criteria)
these widely differing factors is not yet available. Determination of
realistic weighting criteria while difficlut, should be pursued.
It can be concluded, however, that the most toxic compounds (for
example, the first 64 items in Table E-6) should be viewed with special
care. Each of these compounds which is produced in sizeable volume, which
has been implicated as having carcinogenic potential or which has known
losses of the product or the greatest potential losses through accidents,
should be evaluated as carefully as possible. Furthermore, some compounds
ranked above 64 should also be considered potential hazards, particularly
if they are produced at higher volumes than some more toxic chemicals,
if they are implicated as carcinogens, or if the processes by which they
are produced are known to have sizeable waste losses of the product.
One important observation to be noted is that only 41 (64 percent)
of the first 64 compounds have any one of the other 3 data available and
that compounds with 2, or all 3, correlated data are very few. Thus,
any scheme that can be developed for quantifying assessment of these four
data types can only be applied to a very few of the compounds at the present
time.
It should also be pointed out that the accuracy of the LD50 levels
shown in Table E-6 is essentially unknown. Where LD50 data have been
obtained on the same compound in two or more testing programs the results
may or may not agree closely. This can be quickly seen by scanning the
data in Table A-l. However, in some cases the variation is relatively
great. This is shown as follows:
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IOC LD50 Values,
Item No. oral-rat Ratio
39 5700/3800 1.5
51 3100/1230 2.5
70 4360/790 5.5
81 8790/2940 3.0
103 2078/886 2.3
111 2020/242 8.3
116 1400/290 4.8
201 580/95 6.1
308 2828/1297 2.2
The reasons for these variations (many sizable) are unknown but presumably
is related to study protocol or data processing differences. They show
that rating schemes must be viewed with caution!
Oral Toxicity (LD50, Animal Other Than Rat) (Tables E-7 and E-13)
Oral toxicity LD50 data are also available in which animals other
than rats were used. Data of this type up to LD50 values of 500 mg/kg
are listed in Tables E-7 and E-13. These are data on compounds not listed
in Table E-6, i.e., not subjected to acute oral toxicity tests using rats.
The same additional correlated data are present, but fewer of these data
are available. Similar LDLo data are found in Table E-8, not discussed.
Table E-7 compounds should be roughly comparable in potential toxic
hazard to those in Table E-6 at similar LD50 values. However, it should
be pointed out that in some cases where LD50, oral values have been deter-
mined on two or more animals, the results vary widely, e.g., by ratios
as great as 50/1. The following data variations cited from Table A-l
illustrate this:
IOC LD50 Values, LD50
Item No. animal Ratio
10 17 rat/3 mus 5.7/1
12 46 rat/7 rbt 6.6/1
16 340 rat/2400 mus 7.1/1
19 54 rat/96 mus 1/1.8
25 3030 rat/200 mus 15/1
37 1300 rat/28 mus 46/1
41 890 rat/75 bdw 12/1
75 180 rat/900 mus 1/5
83 500 rat/100 rbt 5/1
89 76 rat/165 mus 1/2.2
111 2020 rat/242 mus 8.3/1
114 300 rat/6 mus 50/1
160 698 rat/316 mus 2/1
163 2800 rat/1122 mus /I
165 535 rat/3700 mus 1/6.9
30
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IOC LD50 Values, LD50
Item No. animal Ratio
173 268 rat/1265 mus 1/4.7
191 1020 rat/400 rbt 2.6/1
265 481 rat/60 mus 8.0/1
309 447 rat/1414 mus 1/3.2
312 891 rat/2462 mus 1/2.8
314 1072 rat/330 mus 3.1/1
340 1860 rat/65 mus 29/1
368 5000 rat/316 nus 15/1
These data variations nay be partly due to differences in response between
animal types, or as above, to test or data evaluation protocol variations.
These data comparisons certainly reinforce the conclusion that rating
schemes must be approached cautiously. They also indicate the need for
additional, more carefully controlled tests to be done on many compounds,
using a common protocol.
Inhalation Toxicity (LC50) (Tables E-9 and E-13)
The inhalation data that are most reasonably grouped together (LC50)
are presented in Tables E-9 and E-13. They are grouped in a roughly ordered
fashion in Table E-9. Due to the variations in test protocols and data
units comparisions must be viewed with caution and some skepticism. These
data in Table E-9 are displayed with the same correlated data that are
in Tables E-7 and E-8. Similar comments apply to their utility except
that the relative ordering presented is probably less likely to be accurate,
as described above, than the data in Tables E-7 and E-8. Nevertheless,
it is clear that some compounds are more toxic than others when inhaled
and the relative toxicity indicated by the rating order is probably a
reasonable approximation of actual toxic hazard.
The number of these compounds (31) is a relatively small percentage
(7.4 percent) of the IOC. It is no doubt an appreciably higher percentage
of the volatile compounds (not accounted) but still surely represents
only a minor fraction of the total. An appreciable number of the compounds
in the table do have production volume data and some emissions data.
These items should be analyzed in detail to determine which ones present
the greatest hazard potential. However, the master list of IOC should
also be reviewed to determine which volatile compounds with no quantitative
inhalation toxicity data are produced in moderate to large volume, or
are potential carcinogens, or have other acute or chronic test data that
indicate they are moderately to highly toxic, or have quantitative emissions
data.
Also, as in the case of the oral LD50 test data, there is an obvious
need for testing using common protocols and data evaluation procedures.
Round robin testing involving several laboratories should probably be
done on selected compounds that are most likely to represent high hazard
potential, using both LC50 and LD50 routes, to determine the reproducibility
31
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of these toxic test data and the effects of the different exposure modes.
Mixed Toxicity Data (Table E-10)
The data presented in Table E-10 cover a vide variety of animal type,
administration route, etc. Consequently, these data cannot be rated accord-
ing to relative toxicity. They are, hovever, at least crude indications
of toxicity of high to noderate levels and provide additional compounds
which need further consideration.
s
Production Volume Data
Production volume data are listed in Tables E-ll and E-12. All but 1978
(Table A-l) production volume data are presented in Table E-ll. These
data are ranked according to 1973 production in Table E-12. There are
a total (Table E-ll) of 36 compounds with production levels - 1 billion
Ibs/yr and 102 with production levels ^ 100 nillion Ibs/yr. The production
levels are sttmarized below.
Production Level, Number of
kg/yr (Ibs/yr) Compounds Listed
>. 4.5 x 108 (HO9) 36
4.5 x 107 - 4.5 x 108(108-109) 66
4.5 x 106 - 4.5 x 107(107-108) 52
4.5 x 1(P - 4.5 x 106(106-107) 9
The highest volume products, especially those in the first two categories
(^_ 45 million kg/yr or >_ 100 million Ibs/yr) should be most carefully
reviewed for hazard potential. Even if these compounds are only slightly
toxic, they nay constitute potential hazards because of the greater
opportunity that large quantities eight escape to the environment during
production or use. Consequently, all data available on these compounds
should be reviewed with particular care.
ODP EXTRACTION TABLES
There are 6 ODP extraction tables. These are discussed briefly belov.
>Cany of the consents listed above under the IOC extraction tables also
apply to the ODP extraction tables, where the same data types are presented.
U.S. Occupational Standard (USOS) for
Concentrations in Air — Organic Dyes and
Listed Alphabetically According
to Compound (Table G— 1)
The sane concents apply as for the IOC. Inorganic chenicals are also
listed since these are frequently used in ODP processes in relatively large
amounts under circumstances where greater losses or human exposure potential
day exist. Eovever, further consideration of these inorganics is not pursued
in the present study, as discussed earlier.
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Human Toxicity Data—Organic Dyes
and Pigments (Table G-2)
There are two recorded deaths, one after ingestion of an ODP intermediate
and one upon intravenous exposure to a dye. The same conments apply as
before, under IOC.
Carcinogens and Suspected Carcinogens-^-
Organic Dyes and Pigments (Table G-3)
The discussion under the IOC extraction Table E-4 is also pertinent
here. There are 5 recognized (human) carcinogens included in Table G-3.
Oral Toxicity (Rat)—Organic Dyes and
Pigments (Tables G-4. G-5. and G-6)
LD50, oral-rat data are covered in these tables. Table E-6 is the
equivalent IOC table. Table G-4 covers ODP raw naterials fron Table B-l,
Table G-5 includes ODP intermediates from Table B-2 and Table G-6 covers the
actual dyes and pignents in Table B-3. There are 5 raw materials, 15 inter-
mediates and no dyes and pignents with LD50 values = 500 mg/kg. (There are
also 45 IOC that are D? raw materials in this category.) Those corapounds
that also have available carcinogenic, teratogenic or nutagenic data or
production volume data are indicated in the tables. As discussed earlier
under Table E-6, those substances with commonality of data may represent
greater potential hazards. Certainly compounds that show high acute toxicity
and also show carcinogenic potenital and/or relatively high production
volumes are likely to pose greater toxic hazards.
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SECTION 8
PRIORITIZATION SCHEMES
It is known that some of the compounds in the master tables are toxic
hazards—able or likely to inflict injury or death. If, then, they could
be ranked in some way, it would be possible to start at the top of the
list and work down to some level that is assumed to be safe. This part
of the task is extremely important for it brings the other major objective
of the task into perspective. It is extremely difficult to assess the
treatment and control technology of emissions from all production processes.
However, the assessment would become much more manageable if priority
lists were available and the most hazardous compounds could be subjected
to extensive investigations. Consequently an assessment of the various
factors that might affect toxic hazard potential was undertaken. A number
of factors were identified but no method for utilizing them in actual
rating schemes was developed. This is viewed as a major undertaking that
should be pursued in a separate study. The results of the assessment
are listed at the end of this section for information purposes.
PRIORITY OR RATING LISTS
In the absence of a formula that would allow quantitiative, or even
qualitative, evaluation of all important criteria factors, simplistic
"prioritization" or "rating" schemes were devised based solely on the
principal toxicity (LD50, LC50, carcinogenic TDLo, etc), production volume
and waste product data. These "priority" lists were presented and discussed
in Section 7 above as extraction tables. The extraction tables that can
also be viewed as "priority" lists includes one set of tables which contain
the compounds presented as a function of increasing or decreasing quantita-
ative values of various key data, such as LD50, oral-rat. "Priority rating"
tables of this type include Tables E-2, E-6, E-7, E-8, E-9, and E-12 for
the IOC and Tables G-4, G-5, and G-6 for the ODP. There are also several
extraction tables in which the compounds appear in alphabetical order
since it was not possible to attach an ordinal rating scheme to the data.
However, these tables can still be viewed as "priority" lists, or sets
of compounds that need special consideration as a group, for example those
compounds with carcinogenic data. These "priority" lists include Tables
E-3, E-4, and E-5 for the IOC and Tables G-2 and G-3 for the ODP. Discus-
sions of the reasons for choosing these particular methods of "prioritizing"
or "rating" the chemicals in terms of toxic hazard potential have already
been presented in Section 7.
The "prioritized" lists described above, and in Section 7, provide
a set of tools useful in providing preliminary analysis of the relative
34
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toxic hazard posed by a considerable number of the IOC (probably about
50 to 70 percent of the IOC in Table A-l). Table A-l Addendum could be
treated similarly, although time limitations did not allow this on the
present study. The various lists can be compared with one another to
determine commonality. Of course this has already been done to a consider-
able extent in terms of comparing carcinogenic potential and production
volumes with the various acute toxicity data by including correlated data
on single lists (Tables E-5 through E-10 and H-4 through G-6). However
most of the extraction lists show only minor overlap of the IOC, thus
reflecting the manner in which they were constructed (i.e., for the most
part including only compounds which had not been already covered by a
prior selection process on each new table assembled). Consequently the
set of "priority rating " lists (tables) represents a number of different
ranked sets that are each fairly unique in terms of compounds included
but which are sufficiently different in ranking method as to make reordering
into a master list of ranked compounds very difficult. Fusion of the
separate lists into one master list can only be accomplished by assigning
some sort of unifying weighting factors to each data component in each
of the tables. It is not clear at the present time how this can be accom-
plished objectively and accurately. Consequently each of the lists must
be viewed at present as a separate entity. The selection of compounds
for further study cannot yet be done in such a way as to readily and objec-
tively provide a single prioritized set of compounds for action. Neverthe-
less the "priority" lists as a whole do provide a means of selecting several
sets of study candidates, mostly in some approximate order of importance,
to meet such given specific objectives. Once lists of study candidates
have been identified it may be possible, at least in some cases, to develop
a unified list, or a reduced number of lists, through fresh analysis based
on well defined objectives and possibly additional data for background
information.
EPA PRIORITY LISTS
An attempt was made to identify as many EPA priority lists of organic
chemicals as possible. Six (6) lists which resulted form this effort
are included in Appendix F. They were placed between the Appendices for
IOC and ODP "priority" lists for ease of comparison, especially with the
IOC lists. The lists produced are presented in the following tables:
Table F-l. Effluent Guidelines Priority List (IOC - Phase 1)
Table F-2. Effluent Guidelines Priority List (IOC - Phase 2)
Table F-3. Water Quality Planning and Standards Consent
Decree List
Table F-4. Potentially Significant Air Toxicants from the
Office of Air Quality Planning and Standards
(OAQPS)
Table F-6. List of Potentially Hazardous Waste Materials
(reference 18)
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Table F-7. Spills List of Potentially Hazardous Substances.
Table F-5 is a comparison list showing commonality of compounds on the
present study "priority" lists (Tables E-3 through E-10) and the chief
EPA priority lists of interest (Tables F-l through F-4).
The EPA priority lists are for the most part described adequately
by the table titles. The first 4 lists are considered to be the most
pertinent and will be given special attention. The effluent guidelines
lists (Tables F-l and F-2) are taken from reference 19. Twenty (20) of
the 21 entries in Table F-l and 16 of the 19 entries in Table F-2 are
represented on either Table A-l (IOC), or one of the other master tables,
of this study. Most of these representatives are IOC. The water quality
planning and standards consent decree list (Table F-3) contains 66 individ-
ual entries with all but 3 of them (these 3 are mixed ethers, trichloro-
phenols and chlorinated cresols) specific compounds. Thirteen (13) of
these 66 entries (blanks) are not represented on the present study master
tables. This EPA priority list is the result of the so-called 65 toxic
pollutants (both individual compounds and mixtures of compounds, or general
classes of substances) that resulted from the recent court settlement
(20) between the EPA and several environmental groups concerning implementa-
tion of best available technology (BAT) standards by June 30, 1983. The
fourth EPA priority list (Table F-4) contains 22 entries, only one of
which (a plasticizer) is not on the master tables. Thus these first 4
EPA priority lists are concerned with the IOC, ODP, and related substances
that are presently being considered for effluents and emissions pollution
control studies (e.g., Effluents Guidelines BAT standards and new source
performance standards studies). Overall, commonality with master table
entries (IOC, IOC Addendum and ODP) is very high. Most EPA list entries
not included in the present study are insecticides, herbicides, plasticizers,
etc, i.e., compounds that fall outside the scope of this task.
The last two EPA lists (Tables F-6 and F-7) are additional lists of
potentially hazardous chemicals presented here for use in future studies
of the toxic hazard posed by IOC. Table F-6 covers an earlier list of
potentially hazardous materials developed by Booz-Allen, Inc. for EPA
in 1973 (18). Table F-7 is the EPA spills list of substances potentially
hazardous to the aquatic environment recently published in the Federal
Register (5). Due to time constraints they will not be further discussed
in this report.
COMPARISON OF THIS STUDY "PRIORITY"
LISTS AND EPA PRIORITY LISTS
The first 4 EPA priority lists discussed above (Tables F-l through
F-4) were compared with this study "priority" lists (Tables F-4 through
F-10) for commonality of the IOC. All compounds listed on 5 of 7 "priority"
tables were comparison candidates. However not all the IOC on 2 of the
"priority" lists were candidates. Thus, only compounds with LD50 - 500 mg/kg
(57 items) were covered from Table F-6 and only compounds with LC50 = 1000
ppm or ^ 200 mg/m3 (15 items, 1 through 16, item 13 excluded) were covered
from Table F-9. There are a total of 161 different IOC (38.5 percent
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of 418 total IOC) meeting this comparison candidate criterion on the 7
tables. The results of the comparison are presented in Table F-5 with
the data displayed to show the occurrence of this study "priority" list
IOC considered to pose a potential toxic hazard, on each of the 4 EPA
priority lists. The addendum IOC (Table A-2), the updated 1979 data and
the OOP were not included in this analysis because of lack of time.
There are a total of 45 compounds (27.9 percent of the 161 candidates)
common to the 4 EPA lists. The occurrence of an IOC compound on one of the
EPA lists is indicated by an X, 2X or 3X with the numerals referring to the
number of present study "priority" lists containing the IOC compound. Thirty
(30) IOC (item numbers 3, 17, 30, 39, 86, 101, 227, 243, 265, 284, 311, etc.)
show multiple commonality on the EPA priority lists, with all but 2 of them
(243 and 284) also showing multiple commonality on present study "priority"
lists. The 28 IOC showing multiple commonality on both sets of lists should
be given close consideration for further studies.
An accounting of the IOC appearing on the EPA lists shows the following:
Number of These
Total IOC IOC on Present Percent
Entries Study "Priority" List Commonality
Table F-l 25 14 55
Table F-2 21 11 52
Table F-3 62 21 34
Table F-4 22 14 64
This tabulation shows the number of the IOC which are on one or more the
7 "priority" lists that also appear on the EPA priority lists (Tables
F-l through F-4), in comparison to the total number of IOC on each EPA
list (commonality of EPA priority lists with present study master tables).
The degree of commonality ranges from 34 percent for the Consent Decree
list to a relatively high 64 percent for the OAQPS priority list. Presumably
those IOC common to both sets of lists are worthy of closer scruting in
terms of setting priorities on which compounds should be emphasized in
future effluent or emissions studies, with the compounds showing multiple
commonality as described above receiving the greatest emphasis. Of course,
there are also compounds on the "priority" lists developed on this study
which are not on the EPA priority lists that are probably equally good
candidates for early studies (cf Sections 7 and 8 discussions). Further
analysis, beyond that possible on the present task, will be required to pro-
perly set future study priorities. IOC addendum compounds are not included.
COMPARISON OF U.S. OCCUPATIONAL STANDARDS
(USDS) WITH USSR WORKPLACE STANDARDS
Workplace standards have been established by the Soviet government
(21) for 457 chemical substances. These standards are the Soviet equivalent
of our USOS. They are reproduced in Appendix H, (Table H-2). These values
may be of special interest since there is some indication that they were
determined by the experimental use of human volunteers. This is based
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on a private communication from NIOSH (21) and is partially substantiated
by an attachment to a copy of the original Russian article, which was
hand carried to the United States by a former NIOSH employee. The attach-
ment, although not part of the article, refers to principles and procedures
for developing data for industrial air limits from human subject.
Efforts to determine whether human testing was in fact used to establish
the Soviet standards should continue for two reasons. Firstly, these
standards are set at lower exposure levels than the U.S. equivalents in
78 of 84 total comparisons, usually by substantial amounts (Table H-l).
Consequently the Soviet standards may be leading indicators concerning
which of our USOS are candidates for lower exposure level standards.
Secondly, if the Soviet standards were actually established by controlled
human testing, they may represent some of the best toxic hazard data avail-
able, concerning a large set of organic compounds, that were determined
using a common well controlled test protocol. Furthermore they should
represent realistic human exposure levels for avoidance of acute toxicity
effects (chronic effects are very likely not accounted for).
PRELIMINARY ATTEMPTS TO ESTABLISH
RATING CRITERIA
The information most pertinent for evaluating the hazard of each IOC
is, of course, the toxicity data. However, the amount of IOC produced
must also be considered as well as the use that is to be made of the chem-
ical. For if only limited amounts of a very toxic chemical are produced,
the hazard to the population might be much less than a moderately toxic
chemical produced on a large scale. The same applies to the uses to which
a chemical is put. If the use of a moderately toxic substance is such
that a large number of people will be exposed to it, this is much worse
than even a highly toxic compound that is, for example, used entirely
captively or is completely consumed as an intermediate and not an end
product. For example much HCN and acetone cyanohydrin production meets
these criteria (i.e., used captively) and will constitute a problem only
if there are losses occurring during production.
Toxicity Data Pitfalls
The gathering of data is not always a straightforward process, especially
when it is necessary to use secondary sources because of time constraints.
The use of secondary sources introduces the possibilities of inaccurate
recording and in some cases even two closely related secondary sources
do not agree on the information contained in a primary source. This can
be best demonstrated with a concrete example. Thus reference 2 (1975)
gives the following entry under acetamide:
TXDS:orl-rat TDLo: 456 gm/kg/52WC TFX:CAR from
reference TXAPA9 14,163,69.
However, reference 8 gives the following entry under acetamide:
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TXDS:orl-rat TDLo: 360 mg/kg/52W TFX:CAR from
reference TXAPA9 14,163,69; the same reference
as above.
The question arises as to which one is correct, since they are obviously
not equivalent doses.
The reference used in the above examples (23) was consulted and it
was found that neither of the indicated doses could be directly confirmed.
The dose was indicated in the following way: ". . .administration of
2.5% acetamide in the diet of rats for 12 months led to malignant liver
tumors after 12-15 months of observation in approximately 50% of the animals
at risk." There is no place in the article that describes how-much acetamide
"2.5% acetamide in the diet" is. All doses are given in percentage of
the diet and the amount of diet consumed by the rats is not indicated.
It was then determined that when animal food intake is not specified,
it is assumed by NIOSH (reference 2, page xxi) that rats eat 15 gm/day.
Based on this assumption and the average weight of the rats over the 52
week study period it can be calculated that 456 gm/kg is the approximate
amount of acetamide administered. Thus the datum reported in reference
2 is correct but the datum in reference 8 is grossly inaccurate, indicating
that acetamide is a potent hepatic carcinogen in the rat while in fact
being a very weak carcinogen.
Data Unavailability
Inaccurate data may be worse than no data, but there is much information
that is given in an incomplete form or not available at all. For example,
total production figures for many important compounds are not available.
Some of these numbers are considered proprietary, others have never been
sought, and still others are available only for certain years. The problems
with toxicity data are even greater. LD-50 data for oral toxicity in
rats are available for approximately 50 percent of the compounds in Table
A-l, and this is the most abundant single kind of toxicity data available.
The gaps are enormous. It may be that some very hazardous compounds have
never been tested.
Some of the toxicity data is subjective or descriptive rather than
quantitative. This information can be valuable, but comparisons among
different compounds are very difficult with this kind of information.
Tentative Criteria for Use in the
Identification and Priority Listing
of Hazardous Industrial Organic Chemicals—
The problems mentioned above have a direct bearing on the identification
of hazardous compounds. It is necessary to identify which criteria will
be used to determine if a compound is hazardous. It is also necessary
to establish if one criterion is more important than another.
Various criteria are listed below that might be considered for use
in the identification and priority listing of hazardous industrial organic
chemicals. These tentative criteria are the result of consideration of
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several sources of discussions of toxicity data (16) or the potential
toxic hazards posed by chemicals (24-27).
I. NATURE OF TOXICITY INFORMATION
A. Testing Protocols Used
1. Chemical delivery
a. Species of animal used
b. Exposure or administration route
(1) oral ingestion
(2) inhalation
(3) skin absorption
(4) parenteral
(5) subcutaneous
(6) other
c. Rate and duration of exposure
d. Level of exposure
2. Kind of toxicity
a. Acute
b. Subacute
c. Chronic
3. Specific toxicity tests
a. Carcinogenic
b. Teratogenic
c. Mutagenic
d. Others
B. Physiological-Toxic Compound Interaction Factors
1. Factors affecting translocation
a. Lipid versus water solubility
(1) partition coefficients
(2) ionization factors
b. Membrane mobility
2. Biotransformation
a. Metabolism
(1) detoxification (metabolism and exretion)
(2) formation of toxic metabolites
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3. Chemical interactions
a. Synergistic (potentiation) effects
b. Additive effects
c. Antagonistic effects
II. COMPOUND PHYSICAL PROPERTIES
A. Volatility
1. Boiling point
2. Vapor pressure
B. Solubility
1. Water
2. Aqueous/organic partition coefficients
3. Lipid (oil)
III. CHEMICAL PRODUCTION FACTORS
A. Production Volume
B. Process Type
1. Continuous
2. Batch
3. Aqueous versus nonaqueous
4. Toxic by-products
C. Process Losses
1. Amount
2. Source type
a. Continuous
b. Intermittent (upset conditions, spills, etc)
3. Escape route
a. Air
b. Water
c. Particulates
d. Solids or sludges
D. Process Controls
E. Waste Disposal Practices
F. Demographic Factors
IV. USES
A. Downstream Production Processes
B. End Products
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1. Level of contamination with chemicals
2. Persistence of chemicals in products and
in the environment
a. Loss mode
b. Loss rate
Admittedly, all of this information is probably not available for
even one compound; but even if it were, the task of identifying hazardous
industrial organic chemicals would still exist. The task ahead then is
to determine which are the most important criteria, whether the criteria
will give a yes-no answer, and at what level a substance will be considered
hazardous where quantitative data are involved.
Because of the limited amount of data available for any given industrial
organic chemical and the poor overlap of different types of data, and
the difficult, time-consuming nature of this subtask, it was not possible
to choose criteria and set arbitary cutoff values. Further analysis of
this problem and the type of information available may provide some criteria
in future studies.
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SECTION 9
POLLUTION CONTROL TECHNOLOGY
Published EPA studies are concerned with control of effluents or emis-
sions in a general way, with little information available on control of
specific compounds. The few exceptions concern some studies on emissions
from specific processes (described below). Because of the numerous products/
processes involved in the IOC/ODP industries, only a general survey of
control technologies was possible. Effluent controls are discussed first,
followed by emissions control technology.
EFFLUENT POLLUTION CONTROL TECHNOLOGY
Effluent waste treatment for industrial organic chemical processes
can be conceptually divided into three phases: primary, secondary, and
tertiary (28).
In primary treatment simple separation procedures include the following:
(1) Screening
(2) Equalization or neutralization
(3) Oil separation
(4) Flotation or flocculation.
Then the sedimentation of dissolved or particulate waterborne wastes
can be accomplished by secondary treatments such as the following:
(1) Activated sludge
(2) Extended aeration
(3) Trickling filters
(4) Aerated lagoons
(5) Waste stabilization ponds
(6) Chemical or thermal oxidation.
These treatments convert organic wastes to inactive sediments and waste
streams which are innocuous via biological or chemical conversion.
Tertiary treatments can be applied to remove refractory contaminants.
These include such treatments as:
(1) Ammonia stripping
(2) Coagulation and precipitation
(3) Filtration and microscreening
(4) Carbon absorption
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(5) Disinfection
(6) Electrodialysis
(7) Ion exchange
(8) Reverse osmosis
(9) Evaporation.
Sludges produced from these treatment processes can be treated in a number
of ways. However, the treatments generally include the following:
(1) Aerobic stabilization
(2) Anaerobic digestion
(3) Lagooning
(4) Heat treatment.
Also generally usable are dewatering processes such as filter presses, vacuum
filters, centrifuges or sand-drying beds.
The most complete assessment of effluent control technologies is contain-
ed in a recent report (19) done for the National Commission on Water Quality.
The best current technologies for treatment of effluents are summarized
as follows:
Activated carbon adsorption
Activated carbon regeneration
Activated sludge
Aerated lagoon
Aeration, biological processes
Aerobic digestion
Clarification
Dissolved air flotation
Equalization/surge storage
Filtration, dual media
Neutralization
Oil separation
Ozonation
Precipitation, coagulation and flocculation
Thickening
Trickle filtration
Vacuum filtration.
Details of the characteristics and efficiencies of these technologies
are given in that report, Appendix A, pages A-l through A-29. Applicability
and efficiencies of organic pollutant removal vary widely depending on
the chemical/process in question. Thus it is very difficult to specify
"best" technologies. However activated sludge and carbon absorption proces-
ses appear to be especially attractive and useful technologies.
AIR POLLUTION CONTROL TECHNOLOGY
As early as 1967 reasonably adequate basic air pollution control technol-
ogy was available to the industrial organic chemical industry. Hearings
before the Subcommittee on Air and Water Pollution of the Committee on
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Public Works, March 15-18, 1967, delineated the following general controls
technologies:
(1) Incinerators - flame and catalytic
(2) Condensation units
(3) Absorption
(4) Tight systems.
The Houdry Division of Air Products and Chemicals Inc. and Monsanto
Research Corporation have done the most in depth studies of atmospheric
(air) emissions from the petrochemical industry, Houdry under EPA Contract
No. 68-02-0255 and Monsanto Research Corporation under Contract No's.
68-02-1320 (Task 17) and 68-02-1874. Issued reports in the Houdry series
include a four volume survey of the industry (29-32) and a six volume
series (33-38) pinpointing selected high volume organics. The four volume
series of reports surveyed 33 distinctly different processes used to produce
27 different petrochemicals chosen, according to the authors, from more
than 200 petrochemicals currently in production in the United States.
Many of these products are produced by two or more processes that are
substantially different with respect to process techniques and source
of air emissions. Excluding the polymers studied, the following list
of petrochemicals was included in the study.
IOC
Item
Number Houdry Compound
3 Acetaldehyde (2 processes)
7 Acetic acid (3 processes)
8DP Acetic anhydride
17DP Acrylonitrile
18 Adipic acid
2ADD Adiponitrile (2 processes)
84 Carbon disulfide
124DP Cyclohexanone
199 Ethylene
204 Ethylene dichloride (2 processes)
221DP Ethylene oxide (2 processes)
227DP Formaldehyde (2 processes)
232DP Glycerol
243 Hydrogen cyanide
265 Maleic anhydride
"Oxo" alcohols and aldehydes
70DP n-butanol
248DP isobutanol
223 2-ethyl hexanol
254 isooctanol
128 n-decanol
80 n-butyraldehyde
250 isobutyraldehyde
331DP Phenol
338DP Phthalic anhydride (2 processes)
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268 Styrene
374DP Terephthalic acid (includes dimethyl terephthalate)
82ADD (TDI) Toluene diisocyanate (includes MDI and PAPI)
62ADD (MDI)
403 Vinyl acetate (2 processes)
404 Vinyl chloride
This list includes 23 chemicals, if "oxo" alcohols and adehydes are consider-
ed as one, or 29 chemicals using the indicated list of 5 "oxo" alcohols
and 2 "oxo" aldehydes, and 32 processes.
A summary listing of pollution control devices found to be used in
these very representative processes included the following:
(1) Incinerators (thermal and catalytic)
(2) Flares
(3) Scrubbers (water or organic liquid absorbent)
(4) Bag filters (bag houses)
(5) Cyclones
(6) Electrostatic precipitators.
With the addition of solid adsorption (e.g., charcoal) techniques, these
pollution control technologies, although relatively few and inherently
rather simple in concept, may be adaptable to control many of the air
pollution problems in the industrial organic chemicals industry, when
properly designed and utilized. It should be noted that these control
technologies are generally utilized as add-on controls. Better results
might be realized from in-process modifications, where applicable, or
from combinations of in-process changes plus add-on controls.
The Monsanto Source Assessment study (EPA Contract 68-02-1874) resulted
in emissions data on at least 85 IOC. These data have been incorporated
in the Organic Chemical Producers Data Base Program (12) by Radian Corpora-
tion and have also been included in Table A-l. Assessment of control
technologies used in the processes represented by these emissions data
is not available at this time.
It may be more appropriate to summarize the add-on control methods
which may be applicable to the vapor and liquid-phase (droplets) air emis-
sions associated with the synthetic organic chemicals industry differently
as follows:
(1) Incineration
(2) Adsorption on solids
(3) Absorption by liquids
(4) Condensation (vapors only)
(5) Other methods.
Incineration
Incineration has been widely used to control hydrocarbon emissions.
Three types of combustion are used in incinerators: flame combustion,
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thermal combustion, and catalytic combustion. In all cases, an auxiliary
fuel must be added to support the combustion when dilute gas streams are
involved. A special type of incinerator is the waste heat boiler, in
which the heat from the combustion is used to generate steam.
Adsorption
Adsorption of vapors or droplets onto a solid such as activated char-
coal or a molecular sieve is an attractive emission control method because
it permits recovery of the vapors and thus allows for by-product credits.
Absorption
Absorption of vapors or droplets by a liquid reagent is a possible
control method. The scrubber effluent has to be treated to separate the
liquid reagent, which should be recycled, from the recovered compound
in order to avoid secondary pollution problems.
Condensation
Condensation of the vapors by a cooling water condenser and/or refrigera-
tion may be possible, at least as a first stage method, for some of the
more concentrated effluent gas streams.
These control methods are designed primarily for volatile organic
compounds, but some processes may emit liquid mist or solid particulates
of rather high vapor pressure (e.g., naphthalene). The add-on control
methods which may be applicable to the liquid- and solid-phase (particulates)
air emissions associated with the organic chemicals industry include the
following types of equipment:
(1) Inertial separators
(2) Wet collection devices
(3) Baghouses
(4) Electrostatic precipitators
(5) Other collection devices.
Inertial Separators
Inertial separators are the most widely used devices for collecting
medium- and coarse-sized particulates. They operate by the principle
of imparting centrigual force to the particle to be removed from the carrier
gas stream by directing the gas in a circular path or effecting an abrupt
change in direction. Inertial separators include cyclones and mechanical
centrifugal devices.
Wet Collection Devices
Wet collection devices use a variety of methods to wet the contaminant
particles in order to remove them from the gas stream. The particles
are removed by contact with a liquid droplet or by impingement of wetted
or unwetted particles on collecting surfaces followed by their removal
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from the surfaces by flushing with a liquid. Types of wet collection
devices include venturi scrubbers, mechanical scrubbers, cyclone-type
scrubbers, and orifice-type scrubbers.
Baghouses
When high collection efficiency on small particle size is required,
the most widely used method consists of separating the dust from the carrier
gas by means of a fabric filter. The fabric is usually made into bags
of tubular or envelope shape, and the entire structure housing the bags
is called a baghouse.
Electrostatic Precipitators
The electrostatic precipitator design is based on passing a dust-laden
gas stream through a highly charged electrostatic field which then charges
the dust or smoke and causes agglomeration and precipitation of the accumula-
ted particles.
Other Collection Devices
Other particulate-collecting devices with limited application include
settling chambers, impingement separators, and panel filters. Settling
chambers collect particles with a sufficiently high settling velocity
by the action of gravity forces. Impingement separators are usually used
to collect mists by inertial impaction. Panel filters, similar to those
used in home furnaces, have several important industrial applications
including the collection of overspray from paint-spraying operations.
As an example of matching process groups and control approaches for
the purpose of identifying specific emission control methods, the advantages
and disadvantages of major hydrocarbon control processes are summarized
below:
ADVANTAGES AND DISADVANTAGES OF MAJOR
ORGANIC CHEMICAL CONTROL PROCESSES
Process Advantages Disadvantages
Adsorption Can recover organic chem- Limited to low temperatures;
icals; will remove low limited to low concentra-
concentrations of organic tions; must be regenerated
chemicals at low tempera- with steam or by heating or
tures; does not require disposed of; must remove
heat particulates
Direct Flame Simple to operate; destroys Emits nitrogen oxides; may
Incineration organics; little mainte- require expensive heat
nance recovery equipment; may
emit carbon monoxide;
generally requires auxiliary
fuel (energy expenditure)
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Process
Catalytic
Incinerators
Condensation
and
Scrubbing
Advantages
Smaller than a flame unit;
uses less fuel than a
direct-flame unit; less
nitrogen oxide emissions
than a direct-flame unit
Can recover organic chem-
icals, will also remove
particulate matter; con-
ditions stream for other
control units
Disadvantages
Efficiency may decline with
time; susceptible to poisons
including particulates;
requires regular mainte-
nance
Limited to high-concentration
of hydrocarbons; potential
disposal problem; requires
second control unit
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SECTION 10
ORGANIC DYES AND PIGMENTS INDUSTRY
BACKGROUND
No reliable statistics were found on the manufacturing capacities
of any of the companies in the U.S. organic dyes and pigments industry.
However in 1973, 23 of these companies were listed as making only dyes,
10 were listed as making only pigments and 19 were listed as making both
dyes and pigments (15).
INDUSTRY CHARACTERISTICS
The manufacture of dyes and pigments is characterized by the use of
a great variety of batch reactions and a wide spectrum of both inorganic
and organic materials. The starting materials are usually relatively
low molecular weight materials which are built up in the processing to
higher molecular weight substances.
Most manufacturers of organic dyes and pigments make a large number
of individual products. The demands for individual products may be quite
disparate, with the result that a batch of one product might be made only
once a week, but batches of another product enjoying a large demand might
be made every day. Large inventories of dyes and pigments cannot be econ-
omically justified because of the high unit value placed on these substances.
Thus, in 1974, the average unit value of all organic dyes and pigments
manufactured in the U.S. was $2.44 per pound (10). Consequently the waste
effluents from the manufacture of organic dyes and pigments vary greatly
in composition on a daily basis. This unavoidable variation creates diffi-
cult technical problems especially in coping with the wastewater from
dyes and/or pigments plants, and sometimes in dealing with gaseous emissions
as well.
HAZARDOUS SUBSTANCES
All the chemicals used as starting materials to make dyes and pigments
are listed in Tables A-l, B-l, and B-2 together with correlated toxicity,
production process, and a limited amount of waste stream data. Some of
these chemicals show high acute or chronic toxicity. Attention should
in particular be given to all ODP substances which are either known to
be carcinogenic or which are suspected of being carcinogenic. Also of
special note are highly toxic heavy metals (especially lead and mercury)
which are often associated with dye and pigment production. These should
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be rigorously excluded from the effluents. Other less toxic heavy metals
such as nickel, must be held within established safe limits. Among the
organic starting materials the following substances should be given atten-
tion as potentially hazardous materials: acenaphthene, acrylonitrile,
aniline, benzene, chlorinated hydrocarbons, chlorinated phenols, nitrobenzes,
nitrotoluenes, nitrophenols, amines (both aromatic and aliphatic), and
j>-toluenesulfonic acid.
The lists of dye intermediates and dyes (Tables B-2 and B-3 respective-
ly) are very extensive. Very little toxicity data is available on these
substances, hence it will be presumed that the following types of chemicals
are likely to be hazardous:
• all amino compounds
• nitro-substituted compounds, especially those with
one or more solubilizing groups such as -SO^H or -OH
• all chlorinated compounds, especially those with
solubilizing groups such as -SO^H or -OH.
POLLUTION CONTROLS
Battelle interviewed three industry sources to determine industry's
perception of the hazards associated with effluent materials from the
manufacture of dyes and pigments. This brief survey indicated that the
industry feels it can satisfactorily cope with its pollution problems
using existing technology, although some increase in both operating and
capital costs will be necessary. No attempt at independent corroboration
of this was made because of time constraints.
Careful attention must be given to the regulation of process conditions
to avoid accidental emissions of noxious gases such as sulfur dioxide
and nitrogen oxide. Personnel must be carefully trained, well-instructed
and properly supervised in this connection. When it is necessary to use
highly toxic substances such as lead or mercury, the liquid waste effluents
must be collected separately for special treatment to prevent contamination
of large volumes of aqueous effluents. Thus, one industry source advised
Battelle that mercury was still required in some of their processes, but
that all the liquid wastes from such processes were segregated, the mercury
completely recovered by a proprietary system and recycled to the processes.
Emissions Controls
\
One industry source indicated that it feels that virtually all gas
and vapor emissions from the manufacture of dyes and pigments can be effec-
tively controlled by use of appropriate control equipment such as absorbers,
scrubbers, mist eliminators, and filters for the gas streams involved.
This industry source informed Battelle that all equipment which would
result in gas and vapor emissions had been routinely purchased with the
necessary pollution control devices as an integral part of the process
equipment itself. No one type of scrubber or filter will serve for all
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gas and vapor emission problems; hence each piece of process equipment
must have an individual pollution control device specifically designed
to cope with the problem entailed by that piece of process equipment.
However not all companies making dyes and pigments have installed
this type of equipment. Consequently significant emissions of nitrogen
oxides, halogen (chlorine and bromine) fumes, volatile organics, and dusts
still are associated with many processes.
Effluent Controls
One industry source indicated that his company believes that most
wastewater effluent hazards can be effectively controlled (except for
the highly toxic heavy metals) by a central treatment facility. An advanced,
proprietary water treatment system now being tested in full scale operation
at a plant manufacturing disperse dyes has been described to Battelle
as being very promising. The system involved differs from that used ordi-
narily in respect to the employment of carbon absorption beds for primary
treatment of the effluent from the plant first enters a large holding
reservoir which serves as an "equalization" basin. This reservoir holds
a volume of effluent corresponding to about 1.5 days throughout. It serves
to even out surges in the varying composition of the plant effluent.
The highly acidic effluent (containing mainly sulfuric acid as the mineral
acid component) is neutralized with lime. The precipitated calcium sulfate,
together with certain heavy metal compounds and some insoluble salts of
organic acids is removed in clarifiers. The clear liquid passes then
through beds of activated carbon which absorb all colored materials and
many polar, high molecular weight organic chemicals as well. The effluent
waste has the characteristics, on the average, shown below.
CHARACTERISTICS OF LIQUIED EFFLUENT
FROM CARBON TREATMENT SYSTEMS
Characteristic Content, ppm
Biological oxygen demand (BOD) 350
Chemical oxygen demand (COD) 1,000
Iron 10
Nickel 1
Copper 2
Lead 1
Zinc 1
The effluent is further treated in the secondary system (activated sludge)
of a municipal sewage disposal plant.
The activated carbon beds are periodically regenerated in a furnace.
Stack gases from the furnace are passed through an afterburner and the
effluent gases scrubbed with water. The scrubbings are passed into the
equalization basin and treated along with plant wastewater.
The solid wastes (mainly calcium sulfate and some heavy metal compounds)
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are disposed of by landfill. Ideally, the calcium sulfate sludge should
be efficiently de-watered in high pressure hydraulic filters and sent
to a landfill lined with an impermeable (plastic) membrane. Such a landfill
should also be equipped with a system for removal and treatment of leachate
from the pit (owing to the intrusion of rainwater) to insure that there
will be no "secondary" environmental pollution by leaching of this solid
waste.
A further environmental pollution problem in the manufacture of dyes
with a significant solubility in water is much more difficult to deal
with. Such dyes must be precipitated from solution by "salting out".
This manufacturing step requires that large amounts of sodium chloride
be added to the finished dye in the reactor to precipitate it from solution.
The effluent from plants making such products therefore contains large
amounts of salt and much larger amounts of colored substances (i.e., dyes)
than are encountered in effluents from plants making organic pigments,
vat and disperse dyes. Such plants should always be located near the
ocean to avoid contamination of fresh water resources (rivers and lakes)
with salt.
One other approach to the control of hazardous organic materials in
wastewater effluents could be considered. This is the Zimmerman (Zimpro)
process, which is used by some municipal sewage disposal plants for sludge
disposal. The process depends on the fact that any organic compound can
be oxidized, even in aqueous solution, if the solution is heated to a
sufficiently high temperature (7, p 112). However such an application
of the Zimpro process might be prohibitively expensive because of the
low concentration or organic materials (1000 ppm) and the corrosive nature
of the inorganic materials present.
53
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SECTION 11
CONCLUSIONS
The following conclusions are warranted based on an analysis of the
central data compilations and the data extraction lists produced in this
study:
(1) A unique data base useful in the assessment
of the toxic hazard potential of industrial
organic chemicals (IOC) and organic dyes and
pigments (ODP) has been assembled.
(2) The basic compilations, which are master tables
of toxicity, production process, waste products,
production volume and end use data on 418 IOC,
115 ODP raw materials, 722 ODP intermediates, and
1458 actual dyes and pigments (Tables A-l, B-l,
B-2, B-3, and B-3 Addendum, meet an urgent EPA
need for convenient, single source availability
of detailed correlated data for identifying and
selecting groups of compounds for new source
performance standards studies, effluent guidelines
studies and the like. Also an additional 92 IOC
are presented in Table A-2 (IOC Addendum) with
some correlated toxicity and production volume
data but these addendum IOC were not further
analyzed due to time constraints and therefore
are not represented in the following conclusions
concerning the IOC.
(3) Eighteen extraction tables were assembled based
on various simple lists of toxicity data and
production volume data. These may be viewed as
"priority" lists of compounds that should be given
special attention as candidate groups for further
study.
(4) Six IOC extraction tables (Tables E-2, E-6, E-7,
E-8, E-9, and E-12) and three ODP extraction tables
(Tables G-4, G-5, and G-6) were assembled with
the chemicals presented in order of quantitative
toxicity or production volume data. These can be
considered approximate "priority rating" lists.
54
-------
(5) Six IOC extraction tables (Tables E-l, E-3, E-5,
E-10, and E-ll) and three OOP extraction tables
(Tables G-l, G-2, and G-3) were assembled with
the chemicals listed alphabetically. These can
be considered "priority" groups or lists.
(6) Use of the 18 "priority rating" and "priority"
lists to identify the chemicals that pose the
greatest potential hazard must be approached with
great care since the randomly collected data upon
which the lists are based are essentially non-
standard protocol data of unknown accuracy. Be-
cause of this, consolidation of the lists into one
master "priority rating" list is not possible
although one "priority" grouping of all compounds
could be assembled.
(7) Four of six EPA priority lists obtained on this
study (Tables F-l through F-4) were considered of
primary importance and were compared with eight
of the IOC "priority rating" or "priority" lists
(Tables E-3 through E-10). The 45 IOC common to
the two sets of tables (Table F-5) constitutes a
selected group of chemicals for possible further
study, with 28 chemicals which show multiple
commonality (text page 41) of possible special
significance.
(8) More than 100 additional IOC which are not on the
four EPA lists but are on the present study "priority"
rating" or "priority" lists may be equally good can-
didates for further studies.
(9) Although quantitative toxicity data are available
on 80 percent of the IOC, the most prevalent
reasonably uniform test protocol data (59 percent
of the IOC) that can be listed in order of decreas-
ing toxicity (Table F-6) are LD50, oral-rat. Sixty-
four (15 percent of 418 IOC) of the IOC on this
list of 245 compounds constitute potential toxic
hazards (LD50 ^ 500 mg/kg).
(10) LD50, oral-animal other than rat data are also
available (Table E-7) on another 130 of the IOC,
with 16 of these IOC showing LD50, oral data
< 500 mg/kg on compounds with no LD50 - 500 mg/kg.
This constitutes a ground total of 87 IOC (21
percent of 418) with LD50, oral data ^ 500 mg/kg.
(11) Inhalation data (LC50, any animal and test protocol,
Table E-9) are available on 31 IOC (7.4 percent of
418) with 18 of these compounds (4.3 percent) posing a
55
-------
potential toxic hazard (LC50 ^ 1000 ppm or 200 mg/m3).
(12) Quantitative toxicity data are available on only
16 percent of the ODP intermediates and 3 percent
of the dyes and pigments. Consequently the few
compounds identified on the ODP "priority" lists
must represent a very incomplete set of potential
toxic hazards.
(13) The important lists of compounds with animal test
data indicating that they are carcinogens (Tables
E-4 and G-3) or mutagens or teratogens (Table E-5)
are presented in alphabetical order due to the great
variation in test protocols used to obtain the data.
Nevertheless there are some compounds on these lists
that are of greater concern than the rest, including
about 29 compounds that are either known human car-
cinogens, relatively potent test carcinogens (animals)
or are both carcinogens and mutagens or teratogens.
(14) Production volume data are available on 163 IOC
(39 percent of 418 IOC, Table E-ll), with quantitative
toxicity data available on 143, or 90 percent, of
these. This is a very high degree of commonality.
(15) The 102 highest production volume IOC (^ 100 x 106
Ibs/yr) should be given special attention, particular-
ly if they are on one of the toxicity "priority" lists.
IOC products with no production volume data (61 per-
cent of 418 IOC) or those few with moderate to high
production volumes but no toxicity data, are can-
didates for additional data searches or toxicity
testing.
(16) Production volumes are available on fewer ODP
products (20 percent) than on the IOC, with the
number of correlated production volume and toxicity
data very few (25 items, 1.5 percent, 16 percent
commonality).
(17) Quantitative waste product data of uncertain reliability
are available on 119 (28.4 percent) of the 418 IOC
(none on the ODP), including effluent data on 3.8
percent and emissions data on 24.6 percent.
(18) Ninety-five of the IOC (23 percent) have quantita-
tive end use pattern data, with most of these (about
90 percent commonality) showing quantitative toxicity
data.
(19) Definitive criteria for rating toxic hazard
potential could not be established but work
56
-------
should continue on this important task.
(20) A state of the art assessment of pollution
control and waste treatment technology led to
a determination that most of the published
information on these technologies is of a
general nature. Due to wide variations in
production process technology and in the
applicabilities and efficiencies of different
techniques for controlling organic effluents
or emissions, it was not possible to specify
"best" technologies on the present study, given
the broad scope of the program and the time and
funding available for the task.
(21) Because of the complexity of these industries
and the present state of toxicological data
availability and understanding, this study should
be viewed as a beginning effort.
57
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SECTION 12
RECOMMENDATIONS
An extensive analysis of the master tables of coordinated, comprehen-
sive data on industrial organic chemicals (IOC) and organic dyes and pig-
ments (ODP) and the eighteen tables of extracted data produced using this
data base has been carried out. In addition to the results and conclusions
summarized in Sections 1 and 11, a number of areas were identified where
additional analysis of the presently available data would be fruitful and
where new information of potentially great value should be sought. These
areas are summarized in the following outline:
FUTURE WORK OUTLINE
1. Computer Storage of Data (Computer Program)
2. Expand Data Base
(a) Compounds included
(b) Identifying symbols (WLN, Chemical Abstracts)
(c) Toxicity data additions - especially common protocol
(1) Acute
(2) Chronic
(d) Process information
(1) Update present data
(2) Process information on new compound additions
(e) Waste products - quantitative data on specific compounds
(f) Production volumes
(g) Quantitative end use patterns
3. Continue Examination of Present Data Base to Identify New Extrac-
tion Modes
4. Continue Comparison of Various Extraction or "Priority" Lists
(a) Determine commonality of key data
(b) Construct more complex comparison lists
(1) Most toxic compounds - acute toxicity data
(2) Most toxic compounds - chronic toxicity data
58
-------
(3) Highest production volumes
(4) Quantitative waste product data
5. Continue Attempts to Identify the Most Important Criteria for
Determining Toxic Hazard Potential
(a) Continue analysis of the potential criteria outlined in
Section 8
(b) Evaluate the Ames Bioassay Method
(c) Determine whether potentially important criteria have
been overlooked
6. Continue Search for Pollution Control Technology and Equipment
(a) Emphasize specific compound/process technology
(b) General technology advances.
The value of the present data base can be improved by establishing
a computer program that would provide rapid access to data on the IOC
and OOP with a format that would facilitate data comparisions and allow
new data compilation arrangements to be readily assembled for manual
study. The Radian computer program (12) developed to accommodate IOC
should be amenable to modification to include the new data and IOC con-
tained in the present study. A similar program could be developed to
accommodate the OOP entries. The use of the WLN symbols would allow
searches or data compilations keyed to specific chemical structures to be
accomplished readily. These computer bases would allow more facile com-
parisons of the present "priority rating", "priority" group and EPA priority
lists, to identify commonality. Also compilation of new and more extensive
or data inclusive "priority" lists would be accomplished more readily and
efficiently. These could include:
• Compounds listed according to decreasing production
volume correlated with various specific toxicity data
• Compounds listed in order of toxicity data not yet
specifically analyzed (e.g., LD50, animal data
obtained by administering the chemical by routes
other than oral or inhalation)
• Compounds listed in order of total organics emissions
(quantitative data)
• More extensive compilations incorporating multiple data
types
More work needs to be done to insure that all the important data
outlined above are obtained. Potentially important sources of this
information were not utilized on the present study because of time and
funding constraints. These include the following:
59
-------
• Producing companies
- Product brochures
- Annual reports
- Personal contacts
• Industry organizations
- Published reports
- Personal contacts
• Primary literature (computer searches of abstract services)
- Chemical Abstracts
- Index Medicus
- Predicasts.
Collection of information by these routes would no doubt be time consuming
but they might provide significant amounts of new and important data. Some
preliminary work using a few selected search subjects should establish the
value of these approaches.
Some additional process data which could be incorporated into the pre-
sent study are already available in reference 12.
Even without the developmment of a computer program for storage and
retrieval of the data base developed on this study, further analysis of the
present data is possible. Thus new lists such as those outlined above
under computer studies could be manually prepared and used. These efforts
would become even more important if new data were obtained by the methods
outlined above and added to the data base. Comparison of the newer "priority"
lists with each other and with the already available lists should provide
further identification of compounds with the greatest toxic hazard potential.
Of course efforts to identify the most important criteria for evalua-
ting toxic hazard potential should be continued. Also further searches
for and assessment of pollution control equipment and technology needs to
be carried out.
60
-------
REFERENCES
1. Liepins, R., Mixon, F., Hudak, C., and Parsons, T., The Industrial
Organic Chemicals Industry, Chapter 6 In: Industrial Process Profiles
for Environmental Use. EPA 600/2-77-023f, U. S. Environmental
Protection Agency, Cincinnati, Ohio.
2. NIOSH Registry of Toxic Effects of Chemical Substances, U. S.
Government Printing Office, 1977 Edition, Tables A-l, A-2 and B-l and
1975 Edition Tables A-3 and B-2, B-3 and B-4.
3. Sax, I., Dangerous Properties of Industrial Materials. Reinhold,
5th Edition (1979), Tables A-l, A-2 and B-l and 4th Edition (1975),
Tables A-3, B-2, B-3, and B-4.
4. Stecher, R. G. Ed. The Merck Index of Chemicals and Drugs. 8th Edition,
Merck and Company, Rahway, New Jersey (1968).
5. Code of the Federal Register. Title 29, Labor, Parts 1900-1919,
U. S. Government Printing Office, July 1, 1975.
6. Stanford Research Institute. Chemical Economics Handbook, Menlo Park,
California, 1975.
7. Standen, A. Ed. Kirk-Othmer Encyclopedia of Chemical Technology,
2nd Edition, Interscience Publishers, John Wiley and Sons, Inc.,
New York, Vols. 1-22, Supplement and Index (1972).
8. Suspected Carcinogens. Subfile of: NIOSH Registry of Toxic Effects
of Chemical Substances, 1975, U. S. Government Printing Office.
9. Synthetic Organic Chemicals, United States Production and Sales, 1973,
United States International Trade Commission Publication 728, U. S.
Government Printing Office, 1974.
10. Ibid, Preliminary Figures, 1974.
11. Chemical and Engineering News, June 7, 1976, pp 36-37 and June 11,
1979, pp 35-37.
12. Garner, D. N., and Dzierlenga, S. Organic Chemical Producers Data
Base Program, Data Base Report Generator, EPA Contract No. 68-02-1319,
Task No. 51, U. S. EPA, Cincinnati, Ohio, Radian Corporation, August 6,
1976.
61
-------
13. Wilkins, G. E. End Use Patterns for Significant Organic Chemicals.
EPA Contract No. 68-02-1319, Task No. 61, U. S. EPA, Cincinnati, Ohio,
Radian Corporation, July 21, 1976.
14. Environmental Safety & Health Information. ERDA (336) April 16, 1976,
page 3.
15. Steadman, T. R., Helper, E. W. Parsons, T., Wilkins, G. E. and Phillips,
N. P., Organic Dyes and Pigments Industry, Chapter 7 In: Industrial
Process Profiles for Environmental Use. EPA.
16. Loomis, T. A. Essentials of Toxicology. 2nd Edition, Lea and Feiberger,
Philadelphia, Pennsylvania, 1974, 223 pp.
17. Lowenheim, F. and Moran M. Eds. Faith, Keyes and Clark's Industrial
Chemicals. 4th Edition, Wiley-Interscience, New York, 1975.
18. Johnson, H. A Study of Hazardous Waste Materials, Hazardous Effects
and Disposal Methods. Vol. I. EPA 670/2-73-14, U.S. EPA, Cincinnati,
Ohio, 1973, 406 pp.
19. Catalytic Inc. Capabilities and Costs of Technology for the Organic
Chemicals Industry to Achieve the Effluent Limitation of P.L. 92-500.
PB 244544, National Commission on Water Quality, June 1975.
20. EPA Proposes Setting Toxic Restrictions as Part of BAT Guidelines.
In: Toxic Materials News, D. R. Newman, Ed., Washington, D.C., 3
(8), April 15, 1976, pp 59-60.
21. Maximum Permissible Concentrations of Harmful Compounds in Working-
Area Atmosphere. Zdravookraneniye SSSR, 1970, 18 pp (Translated
by D. K. Dreyer, Battelle-Columbus).
22. Haas, B., Private Communication. National Institute of Occupational
Safety and Health, Cincinnati, Ohio.
23. Weisburger, J. H., Yamamoto, R. S., Glass, R. M., and Frankel, H. H.
Prevention by Arginine Glutamate of the Carcinogenicity of Acetamide
In Rats. Toxicology and Applied Pharmacology, 14, 1969, pp 163-175.
24. Principles for Evaluating Chemicals in the Environment. National
Academy of Sciences, Printing and Publishing Office, 1975, 454 pp.
25. Lowrance, W. R. Of Acceptable Risk, Science and the Determination of
Safety, William Kaufmann Inc., Los Altos, California, 1976, 180 pp.
26. Harper, K. Toxic Hazard, The Evaluative Process. In: Chemistry in
Britain, 12, March 1976, 99-101.
27. Geiss, F., and Bourdeau, ECDIN, An EC Data Bank for Environmental
Chemicals. In: Environmental Quality and Safety, Global Asspects of
62
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Chemistry, Toxicology and Technology as Applied to the Environment.
Academic Press, New York, 5, 1976, pp 15-24.
28. Sittig, M. Pollution Control in the Organic Chemical Industry.
Noyes Data Corporation, Park Ridge, New Jersey, 1974, 305 pp.
29. Pervier, J. W., et al. Survey Reports on Atmospheric Emissions from
the Petrochemical Industry, Volume I. EPA 450/3-73-005a, U.S.
Environmental Protection Agency, Research Triangle, North Carolina.
30. Ibid, Volume II, EPA 450/3-73-005b, April 1974, 332 pp.
31. Ibid, Volume III, EPA 450/3-73-005, April 1974, 261 pp.
32. Ibid, Volume IV, EPA 450/3-73-005, April 1974, 287 pp.
33. Schwartz, W. A., et al. Acrylonitrile Manufacture. Volume 2 In:
Engineering and Cost Study of Air Pollution Control for the Petro-
chemical Industry. EPA 450/3-73-006b, U. S. Environmental Protection
Agency, Research Triangle, North Carolina, February 1975, 103 pp.
34. Ibid. Ethylene Bichloride Manufacture by Oxychlorination. Volume 3.
EPA 450/3-73-006c, 1975.
35. Morris, R. B. Ibid. Formaldehyde Manufacture with the Silver Oxide
Process. Volume 4. EPA 450/3-73-006d, March 1975, 94 pp.
36. Ibid. Formaldehyde Manufacture with the Mixed Oxide Catalyst Process.
Volume 5. EPA 450/3-73-006e, March 1975, 82 pp.
37. Field, D. E., et al. Ibid. Ethylene Oxide Manufacture by Direct
Oxidation of Ethylene. Volume 6. EPA 450/3/73/006f, June 1975,
97 pp.
38. Schwartz, W. A., et al. Ibid. Phthalic Anhydride Manufacture from
Ortho-Xylene. Volume 7. EPA 450/3-73-006g, July 1975, 108 pp.
39. M. N. Gleason, et al., Clinical Toxicology of Commercial Products,
3rd Edition, The Williams and Wilkins Co., Baltimore, MD, 1969.
63
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APPENDIX A
TABLE A-1. INDUSTRIAL ORGANIC CHEMICALS-TOXICITY,
Item
No.
1 DP
Compound
Name and
Formula
Acenaphthene
C12H10
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
000083329
(L5661A L
TEEJ)
Toxicology
Skn and muc mem
irr., NEO
TLV Carcinogen
TDLo:600gm/kg/
Yl
TFX:NEO
skn-mus
Acetal (Acetalhyde,
diethyl acetal)
CH3CH(OC2H5)2
000105577
(20V02)
4600 rat LD LO: 500 mg/kg
2582 rbt orl-hmn
Narcotic, based on
animal experiments
LCLo:4000ppm/4H,
3 DP
Acetaldehyde
CH3CHO
(C2H40)
000075070
(VH1)
1930 rat
TCLo:134ppm/
30M
TFX:IRR,ihl-hmn
L irr, CNS
narcotic
LDLo:500 mg/kg
ipr-rat
LCLo:4000 ppm/
4H, ihl-rat
LD50:640 mg/kg,
scu-rat
LD50:560 mg/kg.
USDS air: TWA
100 ppm or
180 mg:m3
Ditto
Ditto
Ditto
Ditto
Ditto
64
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PROCESS, WASTE, PRODUCTION AND USE DATA
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Separation
(Coal tar, light
cycle oils, drip-
oils, reformer
bottoms)
208
Dye intermediate, inter- 1)507
mediate, Pharmaceuticals, 3)331
insecticides, fungicide, 6)1
plastics
Condensation
(Acetaldehyde-
ethanol, acid
catalyst)
123 Water: acetaldehyde,
ethanol, acetal, acid
or salt catalyst
Numerous-including auto- 1)323
mative industry, building 2)2
industry, packaging, 3)331
petroleum industry, sol- 6)105
vents, cosmetics, organic
synthesis, perfumes,
flavors, electrical industry,
appliance, machines, con-
sumer industry
Wacker Process,
Oxidation
(Ethylene, oxygen,
air)
84 Air: ethane (2.2 kg/
Mgl.ethylene (27.4
kg/Mg), acetaldehyde,
methane,methyl
chloride (8.65 kg/Mg).
Water: discharge 4.4
m3 ( 1,200 gal Ions/
ton) containing
chlorinated aldehydes,
also catalyst metals &
acid. See 1)237.
Scrubber vent
to flare
657.2/1972 Synthesis: 50% acetic acid 1)236
and anhydride, 14% n-
butanol, 11%2-ethyl
hexanol, 25% misc:
peracetic acid, pen-
taerythritol, pyridines,
chloral, 1,3-butylene
glycol, trimethylol-
propane, thermosetting
resins; rubber accelerators
& antioxidants, pre-
servative for fruit &
fish; in fuels; hardeners
2)2
3)332
6)601 A
7)1-92
Dehydrogenation,
oxidation or
catalytic
(Ethanol)
124 Air: CO (12.2 Mg per
yr) acetaldehyde,
ethanol ethyl acetate.
Water: 1)326
Plant 1:
Flow-0.0132 m3/kg
product
COD - 186 mg/l
2.42 gm/kg
BOD - 84 mg/l
1.10 gm/kg
Plant 2:
Flow- 1.165m3/kg
product
TOC- 14,500 mg/l
16.74 gm/kg
Ditto
Ditto
1)324
see acetone
251B
1)616
(Continued)
65
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TABLE A-1. (Continued)
Item
No.
4
Compound
Name and
Formula
Acetaldol
(Butyraldehyde,
3— Hydroxy-)
Chem. Abstr.
Registry No.
(WLN)
000107891
(VH1YQ)
Oral Toxicity,
LD5Q, mg/kg
2180 rat
Toxicology TLV
Acute oral —
LD50: 140 mg/kg
skn-rat
Carcinogen
—
(Aldol)
CH3CH(OH)CH2CHO
(C4H802)
Acetamide
CH3CONH2
(C2H5NO)
000060355
(ZV1R)
30g/kg rat
Mild irr, low toxicity
LD50:10gm/kg,
scu-rat
LD50:8300 mg;kg,
scu-mus
TDLo:456gm/kg/
52WC
TFX:CAR,orl-rat
Acetanilide
CH3CONHC6Hg
(CgHgNO)
000103844
(1VMR)
800 rat
1210mus
LDLo:50mg/kg
orl-hmn
Cyanosis, dermatitis
LDLo:1000mg/kg
ipr-mus
LDLo:500mg/kg
orl-dog
Acetic acid
CHgCOOH
(C2H402)
000064197
(QV1)
331 Oral
4960 mus
LDLo: 1200
rbt
TDLo:816ppm/3M,
ihl-hmn,TFX:IRR
Burns, lacrymations,
conjunctivitis, der-
matitis
LC50:5620ppm/1H
ihl-mus
USOS air:
TWA 10ppm
66
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Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Condensation
(Acetaldehyde,
dilute alkali)
85 Water: acetaldehyde,
acetaldol, NaOH
Rubber accelerators; age
resistors; synthesis; per-
fumery; engraving; ore
flotation; solvent; sol-
vent mixture for
cellulose acetate; fungi-
cides; organic synthesis;
printer's rollers; cadmium
plating; dyes; drugs;
dyeing assistant; synthetic
polymers
1)240
2)255
3)346
Ammonolysis
(Ethyl acetate,
aqueous ammonia
128 Air & Water: reactants
& products
Organic synthesis (react- 1 )334
ant, solvent, peroxide 2)3
stabilizer); general sol- 3)332
vent; lacquer; explosives; 8)1
soldering flux; hygro-
scopic agent; wetting
agent, penetrating agent
Acetylation
(Aniline, acetic
acid, benzene
(solv)
17
Benzene
1.8/1973 Rubber accelerator; inhi-
bitor in hydrogen pero-
xide; stabilizer for cellu-
lose ester coatings;
synthesis of intermediates
(para-nitroaniline, para-
nitroacetanilide, parahexy
lenediamine); synthetic
camphor; pharmaceutical
chemicals; dyestuffs; pre-
cursor in pencillin
synthesis, medicine (anti-
septic)
1)79
2)9
3)332
Oxidation
(Acetaldehyde,
ethyl acetate.
air
101 Air: Methane 1 .8 g/kg, —
CO - 3.3 g/kg
Water: Organics 15g/l,
see 6:273
Plant 1 :
Flow-4.17m3/kg
COD- 186mg/l
0.78 gm/kg
BOD5 - 84 mg/l
0.35 gm/kg
Plant 2:
*5
Flow- 0.085 nr'/kg
COD -306,100 mg/l
26.18 gm/kg
BOD5 - 64,000 mg/l
5.44 gm/kg
1104/1973 Synthesis: 40% vinyl
1033.7/1974 acetate, 23% cellulose
954/1975 acetate, 12% acetate
1 278/1 978 esters, 1 0% TPA/DMT,
3% textile processing
2.5% chloroacetic acid,
9.5% misc: Pharmaceuti-
cals; dyes; insecticides.
photochemicals, etc.;
food additive (as
vinegar); natural latex
coagulant; oil-well
acidizer; textile
printing
1)272
2)212
3)333
6)601 A
11)36
(Continued)
67
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TABLEA-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
Acetic acid
See item
above
See item
above
See item above
See item above
8 DP
Acetic anhydride
(CH3CO)20
(C4H603)
000108247
(1VOV1)
1780 rat
Ditto
Ditto
Ditto
Irr, corrosive to eyes
& upper respiratory
tract. Dermatitis on
continued contact
with skn
LCLo:1000ppm/4H,
ihl-rat
LD50:4000 mg/kg,
skn-rbt
USDS air: TWA
5 ppm or 20
mg/m3
Ditto
9 DP Acetone
CH3COCH3
(C3H60)
000067641
(1V1)
5300 rbt
LDLo: 8000
dog
9750 rat
LDL0:50 mg/kg
orl-hmn
TCLo:500 ppm
TFX:eye, ihl-hmn
TCLo: 12,000 ppm/
4H
TFX:CNS, ihl-hmn
Narcotic in high
concen
USDS air: TWA
100 ppm or
2400 mg/m3
68
-------
Process
(Sources
of Compound)
Carbonylation
(methanol.
carbon
monoxide)
Process
No. Associated Wastes
201 Air: hydrogen (5.5
kg/Mg), CO (294
kg/Mg), methane
(12.7 kg/Mg)
Water: 40 kg of
waste (50% pro-
pionic & 50%
higher org)/Mg
(200 dm3/Mg
total)
Total
Waste Production
Treatment 10^ kg/mg Uses
Off-gas See item See item above
scrubber vent above
References
1)497
See acetic acid
101
See acetic acid
Pyrolysis
(acetic acid,
ketene)
105
Air: methane,
ethylene & ketene
Water: sodium
hydroxide & sodium
acetate
758.2/1973
651/1975
682/1978
Normally
burned also
gas scrubber
system
Heavy ends
also burned
95% cellulose acetate
fibers & plastics; vinyl
acetate; dehydrating &
acetylating agent in pro-
duction of Pharmaceuti-
cals, dyes, perfumes,
explosives, etc.; aspirin
Ditto
1 )6-272
2)27
3)333
5)559
13)27
1)285
6) 601A
11)36
Oxidation and
Cleavage, Per-
oxidation
(cumene, air,
hydrogen, sodium
carbonate, sodium
hydroxide, sul-
furic acid.
62% synthetic
acetone (563 mm kg)
produced by this
process in 1973)
37 Most water is re-
cycled, scrub water
contains: cumene
(trace); acetone
Sludge is 904/1973 Synthesis: 25% methyl
incinerated 900/1974 methacrylate, 14%
723/1975 methyl isobutylketone
10% coatings solvent
6% Pharmaceuticals,
5% chemical pro-
cessing volvent,
4.7% bisphenol A,
4.7% cellulose acetate
spinning solvent, 2.6%
hexylene glycol, 2.5%
diacetone alcohol,
2.3% methyl isobutyl
carbinol, 1.8% iso-
phorone, 0.6% mesityl
oxide, misc.; to clean &
dry parts of precision
equipment; solvent for
potassium iodide & per-
manganate; delusterant
for cellulose acetate
fibers
1)122
2)30
3)334
5)559
6)601B
11)36
13)27
(Continued)
69
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Acetone
Chem. Abstr.
Registry No.
(WLN)
See item
above
Oral Toxicity,
LDgQ, mg/kg Toxicology TLV
See item See item above See item above
above
Carcinogen
Ditto Ditto Ditto Ditto Ditto
Ditto Ditto Ditto Ditto Ditto
Ditto Ditto Ditto Ditto Ditto
Ditto Ditto Ditto Ditto Ditto
10 Acetone 000075865 17 rat LCLo:63 ppm/4H,
cyanohydrin (QXCN) ^mus ihl-rat
(Lactontrile, 2- 14rbt LDLo:8.5 mg/kg
methyl) 9 gpg scu-rat
CH3COGH3HCN LC50:575 ppm/2H,
(C4H7NO) ihl-mus
LD50:17 mg/kg,
skn-rbt
70
-------
Process
(Sources
of Compound)
Oxidation
(n-butane)
Process Waste
No. Associated Wastes Treatment
227 Air: hydrocarbon gases —
Water: acetic acid and
a variety of alcohols
aldehydes, ketones,
esters, other organic
acids and ethers
Total
Production
1 06 kg/year Uses
See item See item above
above
References
1)560
Hydrogen
transfer
(Acrolein,
2-propanoO
251B
Ditto
Ditto
1)616
Oxidation -
Dehydrogenation
(2-propanol)
269 Water:
Flow- 1.46m3/Mg
- product
COD- 1.1 kg/Mg
BOD - 3.25 kg/Mg
TOC - 0.35 kg/Mg
Absorber
Ditto
Ditto
1)649
Oxidation
Dehydrogenation
(2-propanol, air)
270
Ditto
Ditto
1)651
Cleavage
(Cumene hydro-
peroxide, sulfuric
acid)
295 Water: acetone (0.46
(see also kg/Mg), phenol (0.08
37) kg/Mg phenol), mesityl
oxide (19.9 kg/Mg
phenol)
Air: hydrogen (15g/Mg
phenol), CO (20 g/Mg
phenol), phenol (1.48
kg/Mg)
Ditto
Ditto
1)695
Addition
Condensation
(Acetone, hydrogen
cyanide)
170
Emission factors:
HCN - 1.0,
acetone - 1.0
245.2/1969
Synthesis: 83% methyl
methacrylate, 17%
higher methacrylates
1)431
2)674
3)335
12)
13)27
(Continued)
71
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
11
Acetonitrile
(methyl cyanide)
CH3CN
000075058
(NC1)
3800 rat
(C2H3N)
Highly toxic
(cyanide)
LCLo:8000 ppm/
4H, ihl-rat
LD50:500 mg/kg,
ipr-mus
LDLo:700 mg/kg
scu-mus
LDLo: 130 mg/kg
scu-rbt
USOS air: TWA
40 ppm or 70
mg/m3
12
Acetophenone
(Phenyl methyl
CH3COC6H5
(CgHgO)
000098862
(1VR)
900 rat
(Ref 2)
300 rat
(Ref 4)
Narcotic in high
concen; hypnotic;
LDLo: 200 mg/kg,
ipr-mus
Ditto
Ditto
Ditto
Ditto
13
Acetylene
H *CH
(C2H2)
025067587
(1UU1)
20% concen may
cause dyspneca &
headache in hmns;
40% may cause
collapse. 900,000
ppm in air, lethal
for rats
14
Acrolein
CH2CHCHO
(C3H4O)
000107028
(VH1U1)
46 rat
7 rbt
LDLo:5 mg:kg
orl-hmn
TCLo:1 ppm
TFX-IRR, ihl-
man
LCLo:153ppm/
10M, ihl-hmn
Lachrymator; irr
to eyes & res-
piratory tract
USOS air: TWA
0.1 ppm or 0.25
mg/m3
72
-------
Process
(Sources Process
of Compound) No.
Ammoxidation 273
(propylene, air
ammonia, sul-
fur ic acid)
Oxidation 2
(ethylbenzene,
air, sodium
hydroxide, man-
ganese acetate)
See acetone above 37
Pyrolysis, BASF 173
process
( Methane-oxygen )
Oxidation 250
(Propylene, oxygen.
cuprous oxide cat)
Waste
Associated Wastes Treatment
Air: acrylonitrile Absorber off-
(5 kg/Mg product), gases to flare
CO (200 kg/Mg),
propane (50 kg/
Mg), propylene
(100 kg/Mg), HCN
(1 kg/Mg product)
Water: ammonium
sulfate, acetonitrile
Air: ethylbenzene, —
acetophenone, a-
phenylethyl alcohol
Water: sodium salts
of byproduct acids.
sodium hydroxide.
ethylbenzene.
acetophenone, a-
phenylethyl alcohol
See acetone above See acetone
above
Air: hydrocarbon Electrostatic
from feedstocks, car- units, water
bon particulates scrubbers.
from incomplete moving coke
combustion beds & bag
Water: filters
Flow -0.0047m3/
kg
COD - 1 ,274 mg/l
5.95 gm/kg
8005 -410 mg/l
1 .92 gm/kg
TOC - 393 mg/l
1.80g/kg
Air: propylene (71 Propylene
kg/Mg), propane absorber
(3.5 kg/Mg), CO off-gas
(73.5 kg/Mg)
Total
Production
1 06 kg/year Uses
68.1/1973 Solvent in hydrocarbon
processes, especially
for butadiene;
specialty solvent;
intermediate, separation
of fatty acids from
vegetable oils; manu-
facture of synthetic
Pharmaceuticals
1 .0/1973 Perfumery; solvent
1 .22/1 974 intermediate for
Pharmaceuticals,
resins, etc.;
flavoring
See acetone Ditto
above
230.2/1974 Synthesis: 33% vinyl
(chemical & chloride & vinylidene
non-chemical chloride; 26% acrylates;
use) 17% vinyl acetate; 20%
acetaldehyde, neoprene.
acrylonitrile, trichloro-
ethylene, cyclooctate*
traene; tetrahydrofuran;
carbon black misc; also
welding & cutting metals
28.0/1974 Methionine (chicken &
dog food fortifiers).
Intermediate for
synthetic glycerol.
polyuretnane, polyester
resins, Pharmaceuticals;
herbicides; tear gas
References
1)656
2)30
3)814
5)559
12)
1)49
2)32
3)905
4)8
12)
1)122
1)437
4)11
3)338
7)1-203
13)28
1)614
2)47
3)342
5)559
10)
12)
(Continued)
73
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
14 (Continued)
LCLo:8 ppm/4H
ihl-rat
LCLo:1570mg/m3/8H
ihl-cat
LCLo:24mg/m3/6H
ihl-rbt
LD5Q:562 mg/kg
skn-rbt
15
Acrylamide
CH2CHCONH2
(C3H5NO)
000079061
(ZV1U1)
170mus
LDLo:126
LDLo:252
Absorbs through
unbroken skn; CNS
paralysis in animals
LDLo:126orl-rbt
LDLo:252mg,
orl-gpg
LDLo:1000 mg/kg,
skn-rbt
USDS air: 0.3
mg/m3 (skn)
Ditto
Qftlo
Ditto
Ditto
Ditto
16
Acrylic acid
CH2H3COOH
(C3H402)
000079107
(QV1U1)
340 rat LCLo:6000 ppm/5H,
ihl-rat
LDLo: 128 mg/kg,
ipr-mus
LD50%280 mg/kg,
skn-rbt
17
DP
Acrylonitrile
CH2CHCN
(C3H3N)
000107131
(NC1U1)
93 rat TD Lo: 16 ppm/20M,
82 rat TFX:PUL, ihl-man
93rbt High toxicity:
little evidence of
accumulation
LC50:576 ppm/4H,
ihl-gpg
LD50:280 mg/kg
skn-rbt
LCLo:500ppm/4H.
ihl-rat
USOS air:
TWA 2 ppm
(skn) or 4.3
mg/m3, 10 ppm
(skn, 15 mini
Human Carcinogen
TCLo:80 ppm/6H/
52W
TFX:NEO, ihl-rat
TDLo: 1700 mg/kg/
37WC
TFX:NEO, orl-rat
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Hydration
(Acrylonitrile,
cone sulfuric
acid, ammonia
or sodium
hydroxide)
274A Water: acrylic acid,
acrylonitrile, ammo-
nia, sodium hydrox-
ide, sulfates,
acrylamide
18.2/1973 Synthesis of dyes, etc.;
polymers or copolymers
as plastics, adhesives,
paper & textile sizes
soil conditioning agent;
f locculants; sewage &
waste treatment; ore
processing; permanent
press fabric
1)659
2)48
3)342
Direct hydroation
over catalysts
(Acrylonitrile,
water, Cu and
Cr oxide
catalysts)
274B Water: some acrylo-
nitrile acrylamide
and N-nitroso-N-
phenyl hydroxyl-
amine inhibitor
Ditto
Ditto
1)660
Oxidation
(Propylene, air)
276 Air: kg/Mg
acetone (0.35),
acrolein(1.85),
ethyl acetate (38.7),
propylene (6.25),
CO (502)
Water: kg/Mg
aery lie acid (10),
polymers (20.6),
hydroquinone (10.65),
acetic acid (35.7),
& ethyl acetate (27.25)
Solvent
recovery
column
59.7/1973
431/1974
Synthesis: 20% ethyl 11663
and methyl acrylates, 2)48
6.8% n-butyl & isobutyl 3)343
acrylates, 6.8% 2-ethyl 6)604
hexyl & other acrylates; 7)1-311
plastics; paper; paints & 12)
coatings; f locculants 13)28
(See Acetonitrile
above)
273 (see Acetonitrile)
614.8/1973 Manufacture: 55% acrylic 1)656
642/1974 & modacrylie fibers & 2)50
552/1975 high strength whiskers; 3)343
20% ABS & SAN co- 5)559
polymers; 5% nitrile 6)606A
rubber; cyanoethylation 11)36
of cotton; synthetic soil 12)
blocks (acrylonitrile poly-
merized in wood pulp);
organic synthesis; grain
fumigant
(Continued)
75
-------
TABLEA-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
17
DP
(Continued)
LC100:784ppm/1H,
ihl-mus
LCLo:120mg/kg/4H,
ihl-dog
LCLo:600 ppm/4H,
ihl-cat
18 Adipicacid 000124049 1900 mus
COOH(CH2)4COOH (QV4VQ) LDLo:3600 rat
'C6H10°4'
Low toxicity, based
on limited animal
studies
LDLo:3600rat
LD50:275 mg/kg
ipr-rat
19
Ally! alcohol
CH2CHCH2OH
(C3H60)
000107186
(Q2U1)
54 rat
96 mus
LCLo:43 dog
LDLo:53 rbt
LDLo: 50 mg/kg
orl-hmn
TCLo:25ppm,
TFX:IRR, ihl-
hmn
Irr to skn, eyes.
respiratory tract;
kidney & liver
damage
LC50:165ppm/
44 inh-rat
USOS air: TWA
2 ppm (skn)
or 5 mg/m
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
76
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Oxidation
(Cyclohexane, air,
catalyst, nitric
acid)
45 Air: nitrous oxides &
nitrogen dioxides,
particulates
Water: metallic catalyst
residues, byproduct
org acids
Emission factors: NC>2 -
12.0, particulates-1.8
711/1973 Manufacture: 90% nylon 1)140
754/1974 fibers & resins, 4% 2)54
668/1975 urethane foams; 5% 3)344
esters for use as plastic!- 6)606B
zers & lubricants; 0.5% 7)1-414
ingredient of foods, as 11 )36
acidulant; insecticides; 12)
adhesives; tanning; textile 13)28
printing; fauna inhibitor;
coatings; detergents;
elastomers
Hydrogen transfer
(Acrolein, 2-
butanol)
251A Emission factors:
hydrocarbons - 3.0
Water:
acrolein (12.5)
methyl/ethyl ketone
(12.5),2-butanol
(7.5), allyl alcohol
(5), polymer (53.5),
& aluminum
hydroxide (82)
Esters for use in resins 1)616
& plasticizers; inter- 2)58
mediate for pharma- 3)348
ceuticals & other 5)559
organic chemicals; 12)
manufacture of glycerol
& acrolein; military
poison gas; herbicide
Dehydration
(Propylene glycol,
catalyst)
(see
289)
Ditto
1)687
Isomerization
(Propylene oxide)
289 Water: kg/Mg
allyl alcohol (13),
terphenyls (12.5),
Liphosphate (5), tars
(25.5), traces xylene,
propyl alcohol
Ditto
1)687
Substitution
Saponification
(Allyl chloride,
dilute sodium
hydride & diethyl
ether)
317 Water: allyl chloride,
allyl alcohol, diallyl
ether
Ditto
1)738
(Continued)
77
-------
TABLE A-1. (Continued)
Item
No.
20
Compound
Name and
Formula
Allyl chloride
(Propene, 3-Chloro-)
CH2CHCH2CL
(C3H5CL)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
000107051 64 rat
(G2U1)
Toxicology
LCLo:3000 ppm
ihl-hmn
Eye & mucous
mem. irr. local
TLV
USDS air: TWA
1 ppm or 3
Carcinogen
—
21G Aminobenzoic acids
(3 isomers)
o-Aminobenzoic acid •
see 35
vase.
constriction 8c
numbness; rapid
body distress
LCLo:290 ppm/8H,
ihl-rat
LD50:7.15 mg/kg
ivn-dog
LDLo:500 mg/kg,
ipr-mus
21 m-Amiobenzoic acid
DP (Benzoic acid, m-
Amtno-)
NH2C6H4COOH
(C7H7N02)
000099058
(ZR CVQ)
TDLo:8400 mg/kg/
84 Dl
TFX:NEO,orl-rat
22
DP
p-Amino-benzoic
acid
000150130
(ZR DVQ)
2850 mus
1830rbt
LDLo:300 mg/kg
orl-hmn
Large oral doses;
nausea, skn rash,
LD50:200 mg/kg
ivn-rbt
23 Aminoethylethanol
amine
[Ethanol, 2-(1,2-
amino-ethyOamino)-],
(2-hydroxy ethyl)
ethylene diamine]
NH2CH2CH2NHCH2CH2OH
(C4H12N2O)
000111411 3000 rat
(Z2M2Q)
Moderately toxic, orl
and skn
LD50:1800 mg/kg,
skn-gpg
24G
Amyl acetates
(8 isomers)
78
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Chlorination 315 Air: kg/Mg
(Propylene, proplylene (13.5),
chlorine) ethyl chloride
(13.5)
Water: sodium
hydroxide
Emission factors: same
as air
Absorber 395.4/1970 Synthesis: ally! alcohol 1)734
& other derivatives; 2)764
thermosetting resins for 3)349
varnishes, plastics, 5)559
adhesives; synthesis of 12
Pharmaceuticals; glycerol
& insecticide
Reduction
(m-, p-nitrobenzoic
acid, catalyst,
hydrogen)
330
Dyes; drugs; perfumes;
pharmaceutical; dye
intermediate
1)768
2)180
3)358
4)53
2)180
3)358
Alkylation 135 Water: Some HCI, Scrubber 6.1/1974 Textile finishing com- 1)356
(Ethylenediamine polymers pounds (antifuming agent, 2)400
and ethylene dyestuffs, cationic sur- 3)359
chlorohydrin or facants; resins, rubber 12)
ethylene oxide) products. Insecticides &
certain medicinals
Esterification
(Amyl alcohols,
acetic acid)
54 Air & Water: acetic
acid, amyl alcohol,
amyl acetate,
sulf uric acid
Emission factors:
hydrocarbons - 2.0
5.4
Solvent for lacquers &
paints; extraction of
penicillin; photo film;
leather polishes; nail
polish; warning odor;
flavoring agent; printing
& finishing fabrics; sol-
vent for phosphors in
fluorescent lamps
1)161
2)31
3)373
5)559
6)608
12)
(Continued)
79
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
24 (n-Pentylacetate)
CH3COO(CH2)4CH3
(C7H1402)
000628637 7400 rbt
(50V1)
TCLo:5000mg/m3/
30 M
TFXrIRR, ihl-hmn
TCLo:188ppm/30M,
TFX:IRR, ihl-hmn
Low chronic toxi-
city; irr to muc mem;
narcotic
LCLo:5200 ppm,
ihl-rat
LDLo:1500mg/g,
ipr-rat
USDS air: TWA
100 ppm or
525 mg/m3
25
sec-Amy I acetate
(Acetic acid, 2-
pentyl ester)
TLCo:200ppm
ihl-hmn
USDS air: TWA
125 ppm or
650 mg/m3
26G
Amyl alcohols
(8 isomers)
26 (n-Pentyl alcohol)
CH3CH2CH2CH2CH2
OH
(C5H120)
000071410
(Q5)
3030 rat
200 mus
LDLo:500 mg/kg
orl-hmn
Possible eye &
upper respiratory
tract irr
LDLo:490 mg/kg,
ipr-rat
Ditto
Ditto
Ditto
Ditto
Isoamyl alcohol,
see 245
27G
Amylamines
(8 isomers)
80
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Esterification
(Amyl alcohols,
acetic acid)
-54 See item above
5.4
See item above
See Item
above
3)373
Oxo process
(Mixed butylenes:
1-butene, 2-
butene, methyl-
propene; CO, H2>
53 Air: CO, butylenes
& alcohols, dimers
Incineration,
off gases to
flare
Solvent; material for 1)159
pharmaceutical prepara- 2)624
tion; organic synthesis; 3)
lubricants; plasticizers; 5)561
additives for oils &
paints; flotation agent;
medicine
Ditto
Ditto Ditto
Ditto
Ditto
Ditto
Substitution
Hydrolysis
(Mixed amyl
chlorides, sodium
hydroxide
244 Water: NaOH,
NaCI,amyl alcohols,
amyl chlorides,
pentylenes & amyl
ether
Ditto
1)542
2)242
Amination
Ammonolysis
(Amyl chloride,
ammonia)
243 Air: amyl chloride,
ammonia, amyl amin
amines
Water: ammonium
chloride, heavy org
Chemical intermediate;
dyestuf f s, rubber chemi-
cal; insecticide; synthetic
detergents, flotation
agent; corrosion inhibitor;
solvent gasoline additive;
pharmaceutical
1)590
2)624
3)374
(Continued)
81
-------
TABLE A-1. (Continued)
Item
No.
27
Compound
Name and
Formula
(n-Pentylamine)
CH3(CH2)4NH2
(C5H13N)
Chem. Abstr.
Registry No.
(WLN)
000110587
(Z5)
Oral Toxicity,
LD50' mg/kg
470 rat
Toxicology TLV
Strong irr —
LD50:1120mg/kg
skn-rbt
LCLo:2000 ppm/
4H, ihl-rat
Carcinogen
__
28G
Amyl chlorides
(8 isomers)
28 Amyl chloride
(Pentane, 1-Chloro-!
000543599
(G5)
Unknown
29
Amyl mercaptans
(1-Pentanethiol)
CH3(CH2)4SH
(C5H12S)
000110667
(SH5)
LCLo:2000 ppm/
4H, ihl-rat
Amylenes
(see 324-
326)
30
DP
Aniline
C6 H5NH2
(C6H7N)
000062533
(ZR)
440 rat
LDLo:1750
cat
LDLo:350 mg/kg
orl-hmn
Forms methemolo-
bin, anoxemia,
depression of CNS,
contact dermatitis;
possible blood
pressure lowering
& cardiac arrythmia
LD50:64 mg/kg
ivn-rbt
LD50:1400 mg/kg
skn-rat
LC50:250 ppm
ihl-rat
USDS air: TWA
5 ppm (skn) or
19mg/m3 (skn)
82
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
See item above
243 See item above
See item above
See item
above
Chlorination
(Pentane, isopen-
tane, chlorine)
242 Air: HCI, C\2, pentanes,
various 05 chloro-
hydrocarbons
Synthesis of other amy I 1) 588
compounds; solvent; 2)839
rotogravure ink vehicles; 3)375
soil fumigation
Ditto
242 Ditto
Ditto
Ditto
Substitution,
Hydrosulfation
(Amylchloride,
sodium or potassium
hydrosulfide, alcohol
solvent)
245 Water: sodium or
potassium chloride,
amyl chloride, amyl
mercaptans, sodium
or potassium hydro-
sulfide, alcohol
solvent;diamyl
sulfide
Synthesis of organic sul- 1)594
fur compounds; chief 2)840
constituent of odorant 3)376
used in gas
Amination
(Chlorobenzene,
liquid ammonia,
cuprous oxide)
Emission factor:
(Process 24) aniline
0.4, nitrobenzene -
0.3, ammonia - 0.3
208/1973 Synthesis: 40% 1)66
250/1974 isocyanates (MDI & 2)105
187/1975 PAPPI), 35% rubber 3)379
276/1978 accelerators & anti- 4)85
oxidants, 6% dyes & 5)559
intermediates, 6% 6)608
hydroquinone, 4% 11 )36
Pharmaceuticals; 12)
explosives; petroleum
refining; diphenylamine;
phenolics; herbicides;
fungicides; textiles,
paper & metallurgical
industry; catalysts;
stabilizers
(Continued)
83
-------
TABLEA-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
See item above
See item
above
See item
above
See item above
See item
above
Ditto
Ditto
Ditto
Ditto
Ditto
31
Aniline
hydrochloride
(Benzenamine
Hydrochloride)
C6H5NH2HCI
000142041
(ZR & GH)
1072 rat
841 mus
See aniline
LDLo:500 mg/kg.
ipr-rat
LD50: 750 mg/kg.
ipr-mus
32
p-Anisidine
CH3OC6H4
(CyHgNO)
000104940
(ZR D01)
1400 rat
Contact derma-
titis, see
aniline
LD50: 1400
mg/kg, ipr-rat
USDS air: 0.1
ppm (skn) or
TWA 0.5 mg/m3
skn)
33
o-Anisidine
CH3OC6H4NH2
(C7H9NOJ
000090040
(ZR BOD
See Aniline
34
Anisole
C6H5OCH3
000100663
(10R)
3700 rat
2800 mus
84
-------
Process
(Sources
of Compound)
Reduction
(Nitrobenzene,
hydrogen.
catalyst)
Process
No. Associated Wastes
31 Water:
Flow- 1.58 I/kg
COD -1 3,400 mg/l
27.2 g/kg
BOD5- 15 mg/l
0.02 g/kg
TOC- 12,1 50 mg/l
19.2g/mg
Total
Waste Production
Treatment 1 0^ kg/year Uses
— See item See item above
above
References
1)109
7)2-419
Ammonolysis
(Phenol,
ammonia,
catalyst)
300
Air: H2, N2,
ammonia, phenol,
aniline
Heavies
incinerated,
waste dis-
posal problems
considered
minimal by
this process
Ditto
Ditto
1)709
Salt formation,
hydrochlorination
(Aniline, hydrogen
chloride)
33
Air: HCI, ether
(solvent)
Dyes; intermediates; 1)114
dyeing & printing; 2)156
aniline black 3)380
Reduction
(o-, p-nitroanisole,
hydrochloric acid,
tin or iron filings)
310
Water: iron or tin
salts or org
Intermediate for azo
dyes & for guaiacol
1)727
2)101
3)381
Ditto
310 Ditto
0.9/1973
Ditto
Ditto
Methylation,
Substitution
(Sodium phenate,
(sodium phenoxide)
methyl chloride)
302A Water: NaCI, NaOH,
phenol, sodium
phenate, methyl
chloride, anisole
Air: methyl chloride
Solvent; perfumery; 1)712
vermicide; 2)102
intermediate 3)381
(Continued)
85
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
See item above
See item
above
See item
above
35 Anthranilic acid
DP C6H4(NH2)COOH
000118923
(ZR BVQ)
4620 rat
Unknown
TDLo:16gm/kg/
24WI,
TFX:NEO, orl-rat
36
Anthraquinone
C6H4(CO)2C6H4
000084651
(LC666BV
1VJ)
Local sensitizer;
contact dermatitis
TDLo:90 mg/kg/
90DC
TFX:NEO, orl-rat
TDLo:72gm/kg/
90D,
TFX:NEO, orl-rat
37
DP
Benzaldehyde
C6H5CHO
(C7H6O)
000100527
(VHR)
28mus
1300 rat
lOOOgpg
LDLo:500 mg/kg
orl-hmn
CNS depression in
small doses; con-
vulsions in larger
doses; contact
dermatitis
LDLo: 5000 mg/kg
ipr-mus
38 Benzamide
CgHgCONH
(C7H7NO)
000055210
(ZVR)
1160mus
86
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Methylation,
Substitution
(Phenol, sodium
hydroxide,
dimethyl sulfate)
302B Water: sodium sulfate,
sodium phenate,
sodium hydroxide,
phenol, anisole,
dimethyl sulfate
See item above
1)712
Hydrolysis &
Hofmann Reaction
(Phthalimide,
sodium hydroxide,
chlorine or bromine,
hydrochloric acid)
226 Water: NaCI or NaBr,
phthalimide, anthra-
nilic acid
Air: chlorine or
bromine
Dyes; drugs; perf u,mes
& Pharmaceuticals
1)553
2)103
3)382
Condensation -
solvent
Condensation - ball
mill
(Phthalic anhydride,
benzene, AICI3,
sulfuricacid,
sodium carbonate,
sodium hydroxide)
223 Water: NaCI, NaOH,
aluminum salts, sul-
224 furic acid, benzene,
phthalic anhydride,
o-benzoylbenzoic
acid
Condenser/
scrubber
I ntermed iate for dyes; 1) 546
organic synthesis; 1 )549
organic inhibitors; 2)103
bird repellent for 3)382
seeds 8)31
Oxidation
(toluene, air,
catalyst)
353
Air: CO, CO2
Water: benzoic
acid, maleic
anhydride,
anthraquinone
Scrubber
Organic synthesis
(especially of dyes &
dye intermediates);
solvent for oils, resins,
some cellulose ethers,
cellulose acetate &
nitrate;flavoring com-
pounds; synthetic per-
fumes; manufacture of
cinnamic acid, benzoic
acid; Pharmaceuticals &
soaps; photo chemicals;
baking chemicals;
insecticides; medicine;
herbicides; corrosion
inhibitors
1)811
2)143
3)402
7)3-363
Ammonolysis
(Benzoyl chloride
ammonia)
337 Air: NHs, HCI
Water: NH4CI, NH3,
HCI, benzoic acid
Organic synthesis
1)780
2)145
(Continued)
87
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
39 Benzene
-------
Process
(Sources Process
of Compound) No.
Transalkylation 349
(toluene, hydrogen.
CQ aromatics.
alkyl-benzenes
Waste
Associated Wastes Treatment
By product formation: —
29 kg/Mg as Cg
aromatic hydrocarbons.
diphenyl, lighter
olefins & paraffins
Total
Production
1 06 kg/year
5130/1973
4587/1974
3482/1975
5059/1978
Uses
Synthesis: 48% styrene,
20% phenol, 17%cyclo-
hexane for nylon, 5%
nitrobenzene, 3% maleic
anhydride, 2% dode-
cylbenzene, dichloro-
benzene, benzene
hexachloride, diphenyl.
insecticides, fumigants;
solvent; paint removers;
rubber cement; antiknock
gasoline
References
1)803
2)156
3)403
4)128
7)3-396
8)51
11)36
13)29
Sulfonation
(benzene sulfonic
acid; 65% oleum;
m-benzene dl-
sulfonic acid;
catalyst)
22
1)91
3)404
Ditto
Ditto
Ditto
Sulfonation 21
(benzene; sul-
furic acid or
oleum or sulfur
trioxide)
Oxidation 355
(benzoin; CuSC>4,
pyridine; acetic
acid; HNO3)
Rearrangement 356
(benzil, sodium
hydroxide, hydro-
chloric acid)
Oxidation 325
(toluene, air.
cobalt toluate.
bromine)
Air: benzene vapors —
from leaks in system
Water: pyridine, acetic —
acid, CuSO4, HNOa,
bensil, benzoin
Air: pyridine
Water: sodium hydro- —
xide, hydrochloric
acid
Air: benzaldehyde, —
toluene
Water: benzoic acid
Emission factors:
toluene - 3.0,
benzoic acid - 1 .0
— Phenol; recorcinol;
organic synthesis;
polymerization;
catalyst; dye
intermediate
— Organic synthesis;
insecticide
— Chemical intermediate;
pharmaceutical
36.8/1 974 Synthesis: 31 % plasti-
cizers, 25% sodium &
benzyl benzoates, 22%
benzoyl chloride, 7%
butyl benzoate, 5%
alkyd resins; vulcaniza-
tion retarder; food pre-
servative; seasoning
1)87
2)163
3)442
7)3-405
1)815
2)168
3)406
1)817
3)406
7)3-149
1)760
2)179
3)406
6)611
7)3-428
12)
13)29
(Continued)
89
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgQ, mg/kg Toxicology
TLV Carcinogen
44
DP
(Continued)
Benzoic acid, amino
(see 22)
45 Benzoin
C6H5CHOHCOC6H5
(C14H1202)
000119539
(QYR&VR
*DXLV)
LDLo: 500 mg/kg
orl-hmn
46
Benzonitrile
Phenyl cyanide
C6H5CN
(C7H5N)
000100470
(NCR)
LDLo:720 rat
High toxicity
LD50: 1200 mg/kg,
skn-rat
LCLo:950ppm/8H,
ihl-rat
LDLo:180 mg/kg,
scu-mus
LDLo:200 mg/kg,
scu-rbt
47
Benzophenone
C6H5COC6H5
(C13H100)
000119619
(RVR)
2895 mus
Unknown
LD50:727 mg/kg
ipr-mus
48
p-Benzoquinone
(also Quinone)
000106514
(L6V DVJ)
(C6H402)
130 rat
2)204
120 rat
3)952
LDLo:40 mg/kg
orl-hmn
Irr to skn & eyes
LCLo:320mg/m3,
ihl-mus
LD50:8.5 mg/kg
ipr-mus
LD50:25 mg/kg,
ivn-rat
USDS air: TWA TDLo:2000 mg/
0.1 ppm or 0.4 kg/28WC,
mg/m3 TFCrNEO,
skn-mus
49
DP
Benzotrichloride
(Toluene, a, a, a-
trichloro-l
CgHsCCIjj
(C7H5CI3)
000098077 600 rat
(GXGGR)
Irr to skn & muc — —
mem
LDLo: 125 ppm/
4H, ihl-rat
90
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
tobacco; flavors;
perfumes; dentifrices;
medicine (germicides);
corrosion inhibitors;
paints & pigments; dyes
Condensation
(benzaldehyde,
potassium
cyanide)
354 Air: ethanol, HCN
Water: benzoin, ben-
zaldehyde, potassium
cyanide
Organic synthesis; inter- 11813
mediate; photopoly meri- 2) 197
zation catalyst; wetting 7)3-365
& emulsifying agent;
stilbesterol products
Ammonolysis
(toluene, ammonia,
MoC<3 catalyst)
324 Air: HCN, other cya-
nide bearing compounds
Emission factors:
benzene - 2.0
ammonia - 2.0
Synthesis of benzoguan-
amine; intermediate for
rubber chemical; sol-
vent for nitrite rubber,
specialty lacquer, &
many resins & polymers
& many anhydrous
metallic salts
1)758
2)198
3)407
12)
Friedel-Crafts
Reaction and
Hydrolysis,
condensation
(benzene, carbon
tetrachloride,
aluminum
chloride
249 Air: HC1
Water: acid, carbon
tetrachloride, aluminum
salts
Solids: tars, aluminum
hydroxide
0.33/1973 Organic synthesis; per- 1)601
0.43/1974 turnery; odor fixative; 2)199
derivatives are used as 3)407
ultraviolet absorbers; 7)3-441
flavoring; polymeriza-
tion inhibitor for styrene;
pesticides
Oxidation
(aniline, MnO2,
H2SO4
15 Air: ammonia
Manufacture of dyes &
hydroquinone
1)75
2)204
3)952
5)562
Chlorination
(toluene, chlorine.
333 Water: chloride salts
(see Item 54 DP)
Synthetic dyes; organic 1 )773
synthesis; insecticide; 2)916
degreasing solvent; dielec- 3)408
trie fluid; lubricating oil 4) 135
additive; coolant 7)5-265
(Continued)
91
-------
TABLE A-1. (Continued)
Item
No.
50
DP
Compound
Name and
Formula
Benzoyl chloride
C6H5COCI
(C7H5CIO)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
000098884
(GVR)
Toxicology TLV
TCLo:2ppm/1M
TFXiIRR, ihl-hmn
Lachrymator,
Powerful eye, skn.
mucous membrane
irr
Carcinogen
—
51
Benzyl alcohol
C6H5CH2OH
(C7H8O)
000100516
(QIR)
3100 rat
4)138
1230 rat
2)1215
1580mus
1040rbt
100bdw
LDLo:500 mg/kg
orl-hmn
Irr to skn & muc
mem, vertigo nausea
& diarrhea
LC50:1000ppm/
8H, ihl-rat
52
Benzyl amine
C6H5CH2
(CyHgN)
000100469
(Z1R)
Highly irr to eye,
skn, mucous
membrane
53
Benzyl benzoate
(Benzoic acid,
benzyl ester)
(C14H1202)
000120514
(RVO1R)
1700 rat
1400mus
2240 cat
1800rbt
1000 gpg
LD50:500 mg/kg
orl-hmn
54 Benzyl chloride
OP (Toluene, -Chloro)
C6H5CH2CI)
(C7H7CI)
000106434
(G1R)
1231 rat
1624 mus
Lacrymator
TCLo:16ppm,
TFX:UNS, ihl-hmn
LC50:150ppm/2H
Ihl-rat
LD50:1000 mg/kg,
scu-rat
USDS air: TWA
1 ppm or 5
mg/m3
TDLo:50 mg/kg
scu-rat,
TFX:NEO
TDLo:2100mg/
kg/51WI,
TFX:NEO, scu-rat
55 Benzyl dichloride
[Benzene, (Dichloro-
methyl)]
C6H5CHCI2
(C7H6CI2)
000098873
(GYGR)
3249 rat
CNS depressant;
strong irr &
lachrymator
92
-------
Process
(Sources Process
of Compound) No.
Exchange, 336
hydration
(benzotrichloride.
benzole acid)
Substitution, 334
hydrolysis
(benzyl chloride.
sodium carbonate)
Amination 335
(benzyl chloride.
ammonia)
Esterification 332
(benzaldehyde.
sodium
hydroxide)
(See benzotri- 333
chloride above)
(See benzyl 333
chloride)
Total
Waste Production
Associated Wastes Treatment 106 kg/year
Emission factors: — —
HCI - 5.0, SO2 - 3.0,
benzoic acid - 0.1
Water: NaCI, sodium — 5.9/1973
carbonate 6.3/1974
Water: secondary and — —
tertiary amine
quaternary salts
Water: sodium hydro- — 0.64/1974
xide, sodium benzoate
benzaldehyde
Emission factors: — 36.5/1972
toluene - 2.0, HCI -
2.0, benzyl chloride -
1 .0, HCI - 2.0
Uses
Medicine; intermediate
for production of
benzoyl groups; inter-
mediate for other
organics
Perfumes & flavors;
photo developer for color
movie films; dyeing
nylon filament, textiles
& sheet plastics; solvent
for dyestuffs, cellulose
esters, casein, waxes.
etc.; heat-sealing poly-
ethylene films; inter-
mediate for benzyl esters
& ethers; local anesthetic;
cosmetics, ointments.
emulsions; ballpoint pen
inks & stencil inks
Chemical intermediate
for dyes, Pharmaceuti-
cals & polymers
Fixative & solvent for
musk in perfumes &
flavors; medicine
(external); plasticizer;
miticide; insect
repellent; cosmetics
Synthesis: 65% butyl
phthalate, 14% benzyl
alcohol, 12% quaternary
ammonium compounds.
dye intermediate;
synthetic tannins; per-
fumery; Pharmaceuti-
cals; manufacture of
photo developer; gaso-
line gum inhibitor;
pencillin precursors
Dyes
References
1)779
2)215
3)408
12)
1)775
2)215
3)409
4)138
12)
1)777
3)410
1)771
2)185
3)410
4)138
7)3-432
12)
1)773
2)914
3)410
5)560
6)611
8)308
12)
1)773
2)159
3)402
(Continued)
93
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
56
Biphenyl
(Dipheny!)
C6HgC6H5
(C12H10)
000092524 3280 rat
(RR)
2410rbt
TDLo:
TFX:IRR, ihl-hmh
Experimentally
caused paralysis &
convulsions in
animals
USDS air: TWA
0.2 ppm or
57
Bisphenol A
(Phenol, 4, 4'-
isopropylidenedi-)
HOC6H4C(CH3)2
C6H4OH
000080057
(QR DXR
DQ)
4040 rat
6500 mam
LD50:150mg/kg,
ipr-mus
USDS air: TWA
0.5 ppm or 2.8
58 Bromobenzene
Phenylbromide
(Benzene, bromo-)
(C6H5Br)
000108861
(ER)
Irr to eyes and
mucous membranes
59G Bromonapthalene
02497514
(L66J BE)
59 (1-Bromonapthalene) Ditto
C10H7Br (L66J BE)
(Naphthalene, bromo-)
60
Butadiene
CH3CHCCH2
(C4H6)
000106990
(1U2U1)
5480 rat
Ditto
Ditto
LCLo: 250,000
ppm/25M, ihl-hmn
Irrtoeyes&muc
mem; ihl of high
concen can
cause unconscious-
ness & death
Ditto
USOS air: TWA
1000 ppm
Ditto
94
-------
Process
(Sources Process
of Compound) No.
Ullmann Reaction, 51
Substitution
(Bromobenzene,
benzene, sodium
or copper)
Alkylation 256
(Phenol, acetone.
HCI)
Waste
Associated Wastes Treatment
Air: benzene —
Water:
Flow - 458.8 dm3/gm
COD -17.1 kg/Mg
TDC - 5.2 kg/Mg
Phenol - 7.1 kg/Mg
Emission factors:
acetone - 3.0,
phenol - 3.0,
Total
Production
1 0^ kg/year
2.3/1971
145/1973
171/1974
214/1978
Uses
Organic synthesis: heat
transfer agent;
fungicides; dyeing
assistant for
polyester
Manufacture: 49% epoxy
resins, 38% polycar-
bonate resins, phenoxy
& polysulfone resins;
brake fluids; fungicide
for textiles & cable
coverings
References
1)152
2)229
3)622
5)560
1)625
2)645
3)420
5)560
6)612
7)1-912
12)
13)29
Bromination
(Benzene, bromine,
catalyst)
50
Air: benzene
Solvent; motor fuels; 1)151
top-cylinder compounds; 2)158
crystallizing solvent; 3)432
organic synthesis
Bromination
(Naphthalene,
bromine, carbon
tetrachloride,
catalyst)
214 Air: hydrogen bromide,
carbon tetrachloride
Water: hydrogen
bromide, napthalene,
bromonaphthalenes
Organic synthesis;
microscopy;
refractometry
1)527
Ditto
Ditto
Ditto
— Ditto
Ditto
Dehydrogenation 59
(n-butenes.
hydrogen, fur-
fural, catalysts-
Dow type B or
Shell 205)
Oxidative dehydro- 240
dration
(n-butenes, air, Hf
furfural or
acetonitrile)
Water:
Flow-417m/Gg
TOC- 100to200g/m3
COD - 250 to 375 g/m3
Solids - 3 to 4 kg/m3
Air: furfural or
acetonitrile
Ditto —
1674/1974 47% styrene-butadiene
1 202/1 975 rubber, 1 7% poly-
1600/1978 butadiene; 8%
syn adiponitrile, 6%
ABS resins; 3% nitrile
rubber; latex paints;
misc.
Ditto Ditto
1)191
2)236
3)437
6)612
7)
13)30
1)584
(Continued)
95
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
See item above
Chem. Abstr.
Registry No.
(WLN)
See item
above
Oral Toxicity,
LDgQ, mg/kg Toxicology
— See item above
TLV
See item
above
Carcinogen
—
61 Butane 000106978
CH3CH2CH2CH3 (4H)
(C4H10)
Asphyxiant
LC50:658 gm/m3,
ihl-rat
Air: TWA 500
ppm
62G Butenes (3 isomers)
(Butylenes)
CH3CH2CHCH2
(C4H8)
Asphyxiant
62
1-Butene
( -butylene)
000106989
(3U1)
Ditto
63
2-Butene
(cis and trans)
000107017
(2U2)
Ditto
64
Isobutylene
(Propene-2-
methyl)
000107017
(1YU1)
Ditto
65G
Butyl acetates
(4 isomers)
65 n-Butyl acetate
(Acetic acid, n-
Butyl ester)
CH3COOC4Hg
(C6H1202)
000123864 14,000 rat LDLo: 500 mg/kg
(4OV1) LDLo: 1500 orl-hmn
gpg TFX:IRR, ihl-hmn
lrrtoeyes&
respiratory tract;
evidence of chronic
systemic toxicity is
inconclusive
LDLo: 1500 mg/kg.
ipr-rat
USOS air: TWA
150 ppm or 710
mg/m3
96
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Dehydrogenation 241 See item above
(n-butane, H2, fur-
fural or acetonitrile)
Waste Total
Treatment Production Uses
— See item See item above
above
References
1)586
Separation
Chem. mfr.; liquidied 1)236
gas; heating; motor 2)239
fuels; refrigerants; 3)480
solvent; flooding agent; 7)3-815
blowing agent;
Dehydrogenation
{n-butane, furfural,
or acetonitrile
solvent)
238 Water: furfural or
acetonitrile, various
€4 hydrocarbons
Air: light hydrocarbons
10,074/1967
87% gasoline; manu-
facture: 6.0% butadiene,
1.9% butyl elastomers,
1.8% secbuyl alcohol,
1.5% polybutenes, 0.5%
specialty chemicals (04
& 05 alcohols, aldehydes
& derivatives) 0.3%
diisobutylene, 0.3% poly-
isobutylenes, 0.25%
keptenes, 0.1%
miscellaneous
Ditto
Ditto Ditto
494/1974 Synthesis: 75% 3)446
butadiene, 23% sec- 13)30
butyl alcohol, 2%
miscellaneous
Ditto
Ditto Ditto
Ditto
3)438
Dehydrogenation 75 Ditto
(isobutane)
Ditto Manufacture: 72% butyl 1)200
elastomers, 18% 3)750
specialty chemicals, 13)40
10% polyisobutylenes
Esterif ication 99 Water: n-butyl acetate,
(n-butanol, n-butanol, acetic acid,
acetic acid, sulfuric acid
sulfuric acid) Air: n-butylacetate,
n-butanol
Emission factors:
n-butyl acetate -1.0,
n-butanol -1.0
36.8/1973 60% solvent in produce 1)268
tion of lacquer, lacquer 2)16
enamels, pyroxylin 3)440
solutions; leather dress- 5)560
ings; perfumes, flavoring 6)613
extracts; solvent for 12)
natural gums & 13)30
synthetic resins; de-
hydration agent
(Continued)
97
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD50, mg/kg
Toxicology
TLV
Carcinogen
66
67
sec-Butyl acetate
(Acetic acid, sec-Butyl
ester)
000105464
(2YOV1)
(C6H1202)
Isobutyl acetate
(see 249)
tert-Butyl acetate
(Acetic acid, tert-Butyl
ester)
000540885
(1XOV1)
(C7H1202)
USDS air: TWA
200 ppm or 950
USDS air: TWA
200 ppm or 950
68G
Butyl acrylates
(4 isomers)
68
n-Butyl acrylate
(2-Propenoic acid,
butyl ester)
(CgH1202)
000141322 3730 rat
(4QV1U1)
LCLo:1000ppm/4H,
ihl-rat
LD50:2000 mg/kg,
skn-rbt
LD50:926 mg/kg
ipr-mus
69 iso-Butyl acrylate
000106638 7460 rat
(1Y10V1U1)
LCLo: 2000 ppm,
ihl-rat
LD50:890 mg/kg,
skn-rbt
70G Butyl alcohols
(4 isomers)
70 n-Butyl alcohol 000071363
DP CH3(CH2)2CH2OH (Q4)
(C4H100)
790 rat
(Ref 2)
4360 rat
(Ref 4)
LDLo:4250
rbt
LDLo:500 mg/kg
orl-hmn
TCLo:25 ppm,
TFX:PUL, ihl-hmn
Mild irr to eyes,
nose & throat; mild
dermatitis
LDLo:970 mg/kg,
ipr-rat
USOS air: TWA
100 ppm or 300
98
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 10$ kg/year
Uses
References
Esterification
(sec-butyl alcohol,
acetic acid, sulfuric
acid)
57 Water: 1% ester, 3%
alcohol
Air: ester & alcohol
vapors
24.9/1967 Solvent for nitrocellulose; 1)166
lacquer; thinners; nail
enamels; celluloid pro-
ducts; artificial leather;
leather finishes; plastic
wood; washable
wallpaper
2)16
3)440
5)560
Esterification
(tert-butyl alcohol
or isobutylene,
glacial acetic acid)
72 Water: acid, alcohol,
acetate
Possible antiknock agent
in gasoline
1)195
2)16
3)483
5)560
Esterification
(Acrylic acid, n-
butanol, benzene)
277 Water: acrylic acid,
sulfuric acid, n-
butanol, n-
butylacrylate,
benzene
Emission factors:
acrylic acid - 2.0,
butyl acetate - 2.0
58.1/1973 Intermediate in organic 1)666
synthesis; polymers & 2)765
copolymers for emulsion 3)441
& solvent coatings, 9)204
adhesives, paints, 12)
binders, emulsifiers 13)30
Esterification
(acrylic acid,
isobutanol,
benzene)
Ditto Water: acrylic acid,
sulfuric acid, iso-
butanol, isobutyl
acrylate, benzene
— Ditto
1)666
2)50
Reduction
(Crotonaldehyde,
hydrogen)
97 Water: n-butanol,
crotonaldehyde
Emission factors:
CO- 152.0, hydro-
carbons - 5.0
Heavy ends 235/1973 20% solvent for surface 1)264
incinerated 254/1974 coatings; manufacture: 2)244
155/1975 14% glycol ethers, 12% 3)441
294/1978 plasticizers, 12%n-butyl 4)178
acetate, 10% amino re- 5)560
sins, 7% n-butyl acrylate, 6)614
10% exports, 15% mis- 7)3-828
cellaneous (e.g., butyl 12)
amines and 2,4-D esters). 13)30
(Continued)
99
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
See item above
Chem. Abstr.
Registry No.
(WLN)
See item
above
Oral Toxicity,
LD50, mg/kg Toxicology
See item See item above
above
TLV Carcinogen
See item above See item above
71 sec-Butyl alcohol
CH3CH2CHOHCH3
(C4H100)
000078922
(QY2)
6,480 rat
LDLo: 6000
rat
LD50:771 mg/kg.
ipr-mus
LCLo: 16000 ppm/
4H ihl-rat
USOS air: TWA
1 50 ppm or 450
mg/m3
72
tert-Butyl alcohol
(CH3)3COH
000075650
(QX)
3500 rat
LDLo: 4500
rbt
LD50:933 mg/kg,
ipr-mus
USOS air: TWA
100 ppm or 300
73
DP
n-Butylamine
C4HgNH2
(C4HHIM)
000109739
(Z4)
500 rat
LCLo:4000 ppm/
4H, ihl-rat
LD50:500 mg/kg,
skn-gpg
LD50:850 mg/kg
skn-rbt
USOS air: CL
5 ppm (skn) or
15 mg/m3 (skn)
74 sec-Butylamine
CH3CH2CH(NH2)CH3
(C4HHN)
000513495
380 rat LD50:2500 mg/kg
225 dog skn-rbt
75
tert-Butylamine
(CH3)3CNH2
000075649
(ZX)
180 rat
900 mus
100
-------
Process
(Sources Process
of Compound) No.
Oxoprocess, 282
Reduction
(n-butyraldehyde,
hydrogen)
Hydration, 55
Sulfation &
Hydrolysis
(n-butenes, sul-
furic acid)
Hydration, 67
Sulfation &
Hydrolysis
(isobutylene.
sulfuric acid)
Reductive 284
Amination,
Amination
(n-butyraldehyde.
ammonia, hydrogen.
alcohol as solvent)
Amination 58
(2-butanol,
ammonia)
Amination 71
(Isobutylene, sul-
furic acid, hydro
gen cyanide, or tert-
butyl alcohol.
ammonia, hydrogen
and Ni catalyst)
Waste Total
Associated Wastes Treatment Production
Air: organic vapors. Heavy ends —
hydrogen burned; pro-
cess involves no
waste water &
minimal air
pollution
Water: butyl alcohol, — 205.6/1973
sodium hydroxide.
sodium sulfate, sul-
furic acid
Water: t-butyl alcohol, — 508.5/1973
sodium hydroxide.
sodium sulfate, sul-
furic acid
Water: reactants, pro- — 1.82/1973
duct, spent catalysts
Emission factors:
butyraldehyde - 3.0,
NH3- 1.0
Air: CC>2, formalde- — —
hyde, alcohols.
ammonia
Emission factors:
butyraldehyde - 3.0,
NH3- 1.0
Air: ammonia, — —
hydrogen
Uses
See item above
95% synthetic methyl
ethyl ketone; solvent;
organic synthesis; enamels
& lacquers; hydraulic
break fluid; industrial
cleaning & paint removal;
ore flotation; fruit
essences, perfumes, dye-
stuffs & wetting agent
Alcohol denaturant.
chemical manufacture;
perfumes; denaturant
Intermediate for emulsi-
fying agent; Pharmaceuti-
cals, insecticides, rubber
chemicals; dyes; tanning
agent; soaps; flotation
agent; corrosion inhibitor;
antioxidants for gasoline;
color photo; curing agent
for siloxanes
__
Intermediate for rubber
accelerators; insecticide;
fungicides; dyestuffs;
Pharmaceuticals
References
1)674
7)3-828
1)162
2)245
3)441
4)178
5)560
7)3-829
12)
13)30
1)186
2)248
3)441
5)560
7)3-829
1)677
2)245
3)441
5)560
7)2-124
12)
1)168
2)245
3)441
12)
1)193
2)245
3)442
(Continued)
101
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgQ, mg/kg Toxicology
TLV Carcinogen
76 tert-Butylbenzoic
acid
(Benzoic acid, t-
Butyl-)
HOOCC6H4C(CH3)3
(C11H1402)
001320167 735 rat
(QVR BX)
Mild local irr
77
78
DP
1,3-Butyleneglycol
(1,3-Butanediol)
(C4H1002)
tert-Butyl phenol
(Phenol, tert-Butyl)
000107880
(QY2Q)
23,000 rat
11,000 gpg
000098544
(QR DX)
5660 rat
(C10Hi40)
Low toxicity
LD50:2520 mg/kg,
skn-rbt
79 p-tert-Butyltoluene 000098511
(Toluene, p-tert-Butyl-)
C4H9C6H4CH3
(C3H16)
(IXRD)
1500 rat
900 mus
2000 rbt
TCLo:10ppm/3M,
TFX:IRR, ihl-hmn
TCLo:20 ppm/3M
TFX:CNS, ihl-hmn
Irr to lungs; CNS
depressant; liver &
kidney damage
after prolonged
exposure
LC50:1500mg/m3
4H, ihl-rat
LC50:248 ppm/2H,
ihl-mus
USDS air: TWA
lOppm
80
n-Butyraldehyde
CH3(CH2)2CHO
(C4H80)
000123728 2490 rat
(VH3)
TCLo:580 mg/m3,
TFX:IRR, ihl-hmn
LD50:2400 mg/kg,
scu-mus
102
-------
Process
(Sources Process
of Compound) No.
Oxidation 70
(tert-butyltoluene,
air, catalyst)
Associated Wastes
Water: tert-butyl
toulene, tert-
butylbenzoic acid
Total
Waste Production
Treatment kg/year
—
Uses
Resins & plastics; alkyd
resin modifier; corrosion
inhibitors
References
1)192
2)187
3)443
7)436
Reduction
(Acetaldol,
hydrogen)
86 Air: ethanol, n-
butanol, 2,4-
dimethy!-1,3-dioxane
Water: dibutylene
glycols, acetaldehyde,
acetaldol, 1,3-butylene-
glycol
Polyesters; polyurethanes; 11241
surface active agents; plas- 2)238
ticizers; humecant; 3)446
coupling agents; solvent; 4)181
food additive & flavoring
Alkylation
(Isobutylene or
tert butyl
alcohol, phenol,
catalysts)
73 Water: isomeric butyl
phenols, isobutylene
polymers
Chemical intermediate for 1)196
synthetic resins, plastic!- 2)641
zers, surface-active agent, 3)451
perfumes & other products;
a permissible antioxidant
for aviation gasoline;
plasticizer for cellulose
acetate; intermediate for
antioxidants,special
starches, oil-soluble
phenolic resins; pour-point
depressors & emulsion
breakers for petroleum oils
& some plastics; synthetic
lubricants; insecticides;
industrial odorants
Alkylation
(Isobutylene or
tert-butyl alcohol,
toluene, sulfuric
acid)
Water: sodium hydro-
xide, tert-butyl toluene
Solvent; intermediate
1)190
2)913
3)452
Hydrogenation
(Crotonaldehyde,
hydrogen)
88 Air: crotonaldehyde,
butyraldehyde
216/1973 Polyvinyl butyral; buty-
rate plastics; coating
fabrics; rubber
accelerators
1)245
2)247
3)453
7)3-873
9)203
12)
103
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD, mg/kg
Toxicology
TLV
Carcinogen
See item
above
See item
above
See item
above
81
n-Butyric acid
CH3(CH2>
(C4H8O2)
000107926
(QV3)
2940 rat
(Ref 2)
8790 rat
(Ref 4)
LDLo:500 mus
LD50:3180 mg/kg,
ipr-mus
LD50:3180 mg/kg,
scu-mus
LD50:800 mg/kg,
ivn-mus
LD50: 530 mg/kg
skn-rbt
Ditto
Ditto
Ditto
Ditto
82 n-Butyric anhydride
[CH3(CH2)
(C8H1403)
000106310
(3VOV3)
Moderate irr
83
n-Butyronitrile
CH3CH2
(C4H7N)
000109740
(NC3)
500 rat
LDLoMOOrbt
LDLo:100 mus
Animal experiments
show high toxicity
similar to cyanides;
poison
LCLo:400 ppm,
ihl-rat
LD50:500 mg/kg,
skn-rbt
84
Carbon disulfide
(CS2)
000075150
(SCS)
LDLo:14 mg/kg,
orl-hmn
LCLo:4000 ppm/
30M, ihl-hmn
TCLo:50 mg/m^/
7Y;TFX:CNS,
ihl-hmn
CNS effect, narco-
tic & anesthetic,
respiratory
failure; death;
permanent damage
may occur in cases
of chronic poisoning
USDS air: TWA
20 ppm; Cl 30
ppm;Pk100
ppm/30M/8H
104
-------
Process
(Sources Process
of Compound) No.
Oxo process 278
(Propylene,
syn gas, toluene
solvent, cobalt
carbonyl catalyst)
(See Acetic Acid) 227
(n-Butane, 02,
catalyst-usually
cobalt acetate)
Total
Waste Production
Associated Wastes Treatment kg/year
Air: CO, propylene. Light ends may —
propane be flared
Emission factors:
CO - 4.0, propylene -
1 .0, propane - 1 .0
—
Uses
See item above
Molded & extruded pro-
ducts; lenses; cable
lacquer; fishing equip-
ment; flavors;
References
1)667
1)560
2)248
3)453
7)3-881
Pharmaceuticals
Oxidation
(n-butyraldehyde,
air or oxygen,
manganese
butyrate or cobalt
salt catalyst)
89 Air: n-butyraldehyde,
233 butyric acid
Emission factors:
hydrocarbons - 2.0
Synthesis of butyrate 1 )247
ester perfume & flavor 2)248
ingredients; pharmaceuti- 3)453
cats; deliming agent; dis- 4)184
infectants; emulsifying 6)719
agent; sweetening "3-881
gasolines 12)
Exchange
(Butyric acid,
acetic acid or
acetic anhydride)
283 Water: acetic acid,
acetic anhydride,
butyric acid, butyric
anhydride
Manufacture of butyrates; 1 )676
drugs, tanning agents 3)453
Substitution,
Displacement
(n-propyl chloride,
sodium cyanide,
n-propyl alcohol)
232 Water: NaCI, propyl
alcohol, propyl
chloride, butyroni-
trile, sodium
cyanide
Air: propyl chloride,
propanol, hydrogen
cyanide
Basic material in industry, 1)568
chemical & pharmaceuti- 2)252
cals intermediate pro- 3)453
ducts; poultry medicines
Substitution,
Sulfiding
(Methane, sulfur)
164 Air: sulfur, H2S,
S02, gaseous
hydrocarbons, CS2
352/1973 Manufacturing: 39% 1)419
355/1974 viscose rayon, 14% cello- 2)283
218/1975 phane, 25% carbon tetra- 3)469
216/1978 chloride; flotation agent, 4)208
veterinary medicine; 6)615
solvent, rubber accelerator 7)4-384
11)37
13)31
105
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
84 (Continued)
LDLo:300 mg/kg,
scu-rbt
LDLo:400 mg/kg,
ipr-rat
85 Carbon tetrabromide
(CBr4)
000558134
(EXEEE)
LDLo:100rat
Narcotic in high
concen
LD50:298 mg/kg,
scu-mus
Air: TWA 100
ppb
86 Carbon tetrachloride
(CCU)
000056235
(GXGGG)
2800 rat LCLo:1000 ppm,
6380 rbt ihl-hmn
TCLo:20ppm,
TFX:CNS, ihl-hmn
LCLo:43 mg/kg,
orl-hmn
TDLo:1800 mg/kg
TFX:SYS&PUL
orl-wmn
TDLo: 1700 mg/kg
TFX:CNS, orl-man
Narcotic; death re-
sults due to respira-
tory failure; in cases
that recover, serious
kidney, liver & lung
damage occurs; lower
doses produce severe
gastrointestinal up-
set, kidney & hepatic
damage
TCLo:300ppm/
(6-15Dpreg)
TFX:TER, ihl-rat
LC50:9526ppm/8H,
ihl-mus
LCLo:4000 ppm/4H
ihl-rat
LDLo: 1000 mg/kg,
orl-dog
LDLo:125 mg/kg,
ivn-dog
USDS air: TWA
10 ppm,'65 mg/
m3 CL: 25 ppm
PK: 200 ppm/
5M/4H
Dec. 1975:
NIOSH recom-
mended std
USDS air: TWA
2ppm/10HD/
40HWor 12.6
mg/m3
TDLo:4800 mg/
kg/88DI,TFX:
CAR, orl-mus
TDLo:133gm/kg/
25WI,TFX:NEO
scu-rat
TDLo:3680 mg/kg/
30WI,TFX:CAR,
orl-ham
TDLo:159gm/kg/
25WI,TFX:CAR,
scu-rat
TDLO:159gm/kg/
20WI,TFX:CAR,
rec-mus
TDLo: 120 mg/kg/
88DI,TFX:CAR,
orl-mus
Ditto
Ditto
Ditto
Ditto
Ditto
106
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Bromination
(Methane, bromine
Carbon tetrachlo-
ride, aluminum
tribromide)
162 Air: bromomethanes,
hydrogen bromide
Organic synthesis
1)416
2)285
3)471
Oxychlorination 140 Air: chlorohydro- Heavy ends 476/1973 Manufacturing: 52% 1)364
(Ethylenedi- carbons, chlorine usually 529/1974 Freon 12,28% Freon 2)285
chloride, chlorine) incinerated 413/1975 11; metal degreasing; 3)471
335/1978 agricultural fumigant; 6)618
chlorinating organic com- 8)89
pounds; production of 13)31
semiconductors; cleaning
agent; fire extinguishers;
insecticide; flour bleaching;
Pharmaceuticals; petro-
leum refining; lubricant
Chlorination &
Pyrolysis
(LPG or natural
gas, ethane, pro-
pane, chlorine,
sodium hydroxide,
inhibitors)
234
Ditto
Ditto
Ditto
1)571
7)5-137
107
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
See item above
Chem. Abstr.
Registry No.
(WLN)
See item
Oral Toxicity,
LD50, mg/kg
See item
Toxicology
See item above
TLV Carcinogen
See item above —
87
Cellulose acetate
009004357
Unknown
88 Chloranil
DP (P-Benzoquinone,
2,3,5,6-tetrachloro-)
C6C-2CI4
(C6CI402)
000118752 4000 rat
(L6V DVJ-/
G4)
LDLo:500 mg/kg,
orl-hmn
CNS depression,
irr to skn & muc
mem
LDLo:500 mg/kg,
ipr-rat
LDLo:4 mg/kg,
ipr-mus
TDLo:71 gm/kg/
78W
TFX:CAR,orl-mus
89 Chloroacetic acid
DP (Acetic acid, chloro-)
CH2CICOOH
(C2H3CI02)
000079118
(QVIG)
76 rat
165 mus
LDLo:50 mg/kg,
orl-hmn
Extremely irr to
eyes, skn, mucoup
membranes
LD50:5 mg/kg,
scu-rat
LDLo:500 mg/kg,
ipr mus
LDLo: 100 mg/kg
TFX:NEO, scu-mus
90G
Chloroanilines
(3 isomers)
(Aniline, Chloro-)
(C6H6CIN)
300 rat
100 mus
100 bdw
Allergens,damage
blood (see Aniline)
TCLo:44 mg/m3
TFX:BLD, ihl-hmn
90 o-Chloroaniline
(Aniline, o-Chloro-)
(C6H6CIN)
000095512
(ZR BG)
256 mus
LDLo:222 mg/kg
skn-cat
LDLo:310 mg/kg,
scu-cat
108
-------
Process
(Sources Process
of Compound) No.
Chlorination 160
(Methane,
chlorine)
Acetylatlon 102
(Cellulose, acetic
acid, acetic
anhydride, sul-
furic acid.
sodium acetate.
sodium
bicarbonate)
Oxidation, 299
Chloroxidation
(2,4,6-trichloro-
phenol, chlorine.
fuming sulfuric
acid)
Chlorination 104
(Acetic acid.
chlorine)
Chlorination 18
& Hydrolysis
(Acetanilide,
acetic acid.
chlorine)
Reduction or —
Chlorination
(m-nitrochloro-
benzene, hydrogen
or aniline, cone
sulfuric acid.
chlorine)
Total
Waste Production
Associated Wastes Treatment kg/year
Air: various chloro- — See item
methanes above
(8 kg/1 00 kg)
Water: — 378.9/1973
Flow: 12-15m3/Mg
(200 g/m3 solids)
degraded cellulose,
sulfuric acid
Air: various solvents
Emission factors:
Hydrocarbons- 10.0
Water: 2,4,6-trichloro- — —
phenol, other chloro-
phenols, chlorine.
sulfuric acid.
chloranil
Water: hydrogen Absorbers, 29.1/1969
chloride, chlorine, scrubbers
sodium hydroxide.
chlorinated byproducts
Air: acetic acid, chloro-
acetic acid, chlorine.
hydrogen chloride
Emission factors:
hydrocarbons - 2.0;
HC1 - 4.0
Air: chlorine — —
__
Uses References
See item above
Manufacturing: 48%
acetate fiber; 20% photo
film, transparent sheet-
ing, thermoplastic
molding composition;
24% cigarette filters;
lacquers; protective
coating solutions
Agricultural fungicide;
dye intermediate; elect-
rodes for pH measure-
ments; vulcanizing agent
Manufacturing: 50% her-
bicide, 40% production
of carboxy methyl-
cellulose; ethyl chloro-
acetate, glycine.
synthetic caffeine.
sarcosine, thioglycolic
acid, EDTA, 2,4-D,
2,4,5-T; synthetic dyes;
medical & Pharmaceuticals
Dye intermediate
Dye intermediate;
standards for color-
metric apparatus; manu-
facture of petroleum
solvents & fungicides
1)411
1)275
6)615
12)
13)31
1)708
2)204
3)1013
1)283
2)17
3)838
7)8-417
12)
1)81
7)2-419
2)94
3)488
109
-------
TABLE A-1. (Continued)
Item
No.
91
Compound
Name and
Formula
p-Chloroaniline
(Aniline, p-Chloro-)
(C6H6C1N)
Chem. Abstr.
Registry No.
(WLN)
000106478
(ZR DG)
Oral Toxicity,
LD5Q, mg/kg
300 rat
420 rat
100 mus
100bdw
Toxicology TLV
TCLo:44mg/m3,
TFX:BLD, ihl-hmn
LD50:420 mg/kg.
ipr-rat
LDLo:125 mg/kg.
scu-cat
LDLo:36 mg/kg.
skn-rbt
Carcinogen
92 m-Chloroaniline
(Aniline, m-Chloro-)
(C6H6C1N)
000108429
(ZR CG)
880 rat
LD50:223 mg/kg,
skn-cat
LDLo: 125 mg/kg,
scu-cat
93G Chlorobenzaldehyde
(3 isomers)
(Benzaldehyde, p-
chloro)
000098884
(VHR XG)
(C7H5CIO)
93 o-Chlorobenzabalde-
hyde
000089985
(VHR BG)
LDLo: 10 mg/kg
ipr-mus
94
DP
Chlorobenzene
(Benzene, chloro-)
(C6H5CI)
000108907
(GR)
2910 rat Strong narcotic with
2830 rbt only slight irr quali-
ties. Prolonged
exposure may cause
kidney & liver
damage
LDLo:7000 mg/kg,
scu-rat
USDS air: TWA
75 ppm or 350
95G o- and p-
chlorobenzoic acids
95
DP
p-Chlorobenzoic acid 026264095
(pHBenzoic acid,chloro-).Q..p J-QI
CIC6H4CO2H
(C7H5CIO2)
110
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
See above item
Dye intermediate, 2)94
Pharmaceuticals, agri- 3)488
cultural chemicals
Ditto
Intermediate for azo
dyes & pigements;
Pharmaceuticals,
insecticides; agricultural
chemicals
2)94
3)488
Chlorination
& Hydrolysis
(Chlorotoluene,
chlorine)
346 Water: chlorobenzal-
chlorides, chloro-
toluenes, aldehydes
Air: chlorine
Intermediate in the pre-
paration of triphenyl
methane & related dyes;
organic intermediate
1)797
2)144
Chlorination
(Benzene, chlorine,
sodium hydroxide
catalyst)
Air: benzene, HCI
Water: HCI, dichloro-
benzene
Emission factors:
benzene - 7.4, ethyl
chloride - 1.3, ethyl-
ene dichloride - 0.1
Absorber, 180.5/1973 Synthesis: 50% nitro- 1)55
stripper chlorobenzenes, 20% 2)158
solvent, 10% phenol, 3)488
DDT; solvent carrier for 5)560
methylene diisocyanate; 6)617
intermediate & solvent 7)5-265
dye intermediate; insect 9)22
repellants; dielectrics; 12)
lubricating oil additive; 13)31
coolant in the electrical
industry
Chlorination &
Hydrolysis,
Oxidation
(o-chlorotoluene
or p-chlorotoluene,
chlorine, zinc
chloride catalyst)
347 Air: HCI & CI2
Water: chlorobenzoic
acids, chlorobenzalde-
hyde, chlorobenzyl
alcohol, sodium salts,
catalyst
Gas absorber
Intermediates for the
preparation of dyes,
fungicides, Pharmaceuti-
cals & other organic
chemicals; glues; paints;
fungicide; plant growth
regulator
1)799
7)3-437
Ditto
Ditto Ditto
Ditto
Ditto
Ditto
111
-------
TABLE A-1. (CONTINUED)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgQ, mg/kg Toxicology
TLV Carcinogen
96G o- and p-
Chlorobenzoyl
chlorides
(Benzoyl chloride,
chloro-)
CIC6H4COCI
(C7H4CI20)
(GVR XG)
96
Chlorobenzoyl
chloride,o-
000609654
(GVR BG)
97
Chlorobenzoyl
chloride,p-
000112010
(GVR DG)
98
DP
Chlorobenzoyl
chloride,m-
000618462
(GVR CG)
99 Chlorodifluoroethane 000075683
(Ethane, chlorodifluoro-)
Freon 142
CIF2C2H3
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Condensation
(Chlorobenzoic
acid, chlorobenzo-
trichloride)
348 Air: HCI, Cl2
Water: chlorobenzo-
trichloride, chloro-
toluene, Chlorobenzoic
acid, HCI
Intermediate for Pharm-
aceuticals, dyes & other
organic chemicals
1)801
Ditto
Ditto Ditto
— Ditto
Ditto
Ditto
Ditto Ditto
— Ditto
Ditto
Ditto
Ditto Ditto
Ditto
Ditto
Chlorination
(Difluoroethane)
176 Air: chlorine, chlori-
nated compounds,
acetylene, some vinyl
chloride
Water: NaCI, NaOH
Acid scrubber
Manufacturing: 52% 1 )445
aerosol propellant, 29% 2)387
refrigerant, 9% foam 3)545
blowing agent, 13)31
miscellaneous
Substitution,
Fluorination
(Chloroform,
hydrogen
fluoride)
161 Air: chlorof luoromethanes —
Water: HCI, NaOH,
NaCI
Manufacturing: 52%
aerosols; 29% refrigerant,
9% foam blowing agent;
chemical intermediate
1)415
2)709
3)491
7)5-126
13)32
Chlorination 159 Air: chloromethanes
(Methane, Water: NaOH, salts,
chlorine) acids
Emission factors:
methyl chloride - '6
26.0, methylene
chloride - 4.0, carbon
tetrachloride -2.0,
chloroform - 2.0,
methane - 2.0
115/1973 Manufacturing: 52% 1)409
134/1974 fluorocarbon refrigants 2)290
& propellants (CHCIF2): 3)493
41% fluorocarbon 5)560
plastics; dyes & drugs; 6)618
general solvent; fumigant; 7)7-126
anesthetic 12)
13)32
(Continued)
113
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
101 (Continued)
LC50:100gm/m3
ihl-dog
LCLo:75 mg/kg,
ivn-dog
LC50:59gm/m3
ihl-rbt
102G Chloronaphthalenes
102 Naphthalene, 1-chloro 000090131 1540 rat TFX:SYS, ihl
(L66J BG) 1091 mus damage to liver
103 Naphthalene, 2-chioro 000091587 2078 rat
(C10H7CI) (L66JCG) 886 mus
104G Chloronitrobenzenes 025167935
DP (Benzene, chloronitro-)
(WNR XG)
Cumulative effects.
Methemoglobin,
cyanosis & blood
changes
o-chloronitrobenzene (WNR BG) 288 rat
35 mus
m-ch loron itrobenzene (WMR CG) 390 mus
TCLo:0.012mg/m3
ihl-hmn,eyes
104 p-chloronitrobenzene 000100005 420 rat
(WNR DG)
650 mus
1414 mus
LD50:420 mg/kg, USOS air: TWA
ipr-rat 1 mg/m^ (skn)
105G Chlorophenols
114
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Chlorination
(Naphthalene,
chlorine, sodium
hydroxide)
213 Water: NaCI, NaOH,
naphthalene, chlori-
nated napthalenes
Air: chlorine
Wax; electrical condenser 1 )525
impregnation; moisture-,
flame-, acid-, insect-proof-
ing of wood, fabric &
other f ibrious bodies;
moisture-, & flame-proofing
covered wire & cable;
solvent (for rubber, aniline
& other dyes; mineral &
vegetable oils, varnish gums
& resins, & other waxes
when mixed in the molten
state
Ditto
Ditto Ditto
Ditto
2)571
Ditto
Ditto Ditto
Ditto
Ditto
Nitration
(Chlorobenzene,
nitric acid,
sulfuric acid)
Air: aromatics
Emission factors:
chlorobenzene -
3.2, N02 - 0.9,
nitro-
chlorouenzene -
0.1
Intermediate, especially 1)61
for dyes; manufacture 12)
of p-nitrophenol, from
which parathion is made
Ditto
Ditto Ditto
Ditto
2)159
3)986
Ditto
Ditto Ditto
Ditto
2)159
3)496
Ditto
Ditto Ditto
63.6/1974 Ditto
2)159
3)858
1)705
(Continued)
115
-------
TABLE A-1. (Continued)
Item
No.
105
Compound
Name and
Formula
(Phenol, m-chloro-)
Chem. Abstr.
Registry No.
(WLN)
000108430
(QR CG)
Oral Toxicity,
LD50' mg/kg
570 rat
Toxicology
LD50:355 mg/kg,
ipr-rat
LD50: 1390 mg/kg.
scu-rat
TLV Carcinogen
— TDLo:6gm/kg/
15WI;TFX:NEO
106 (Phenol, o-chloro-)
DP
000095578
(QR BG)
670 rat
670 mus
LD50:230 mg/kg,
ipr-rat
LD50:950 mg/kg,
scu-rat
LDLo:950 mg/kg,
scu-rbt
LDLo:800 mg/kg,
scu-gpg
TDLo:48gm/kg/
12WI,TFX:NEO,
skn-mus
107 (Phenol, p-chloro-)
DP CeH4CIOH
(C6H5CIO)
000106489
(QR DG)
670 rat LD50:281 mg/kg,
4)245 ipr-rat
LD50:1030 mg/kg,
scu-rat
108 m-Chlorotoluene
(Toluene, m-chloro-)
(C7H7CI)
000108418
(GR C)
Narcotic in high
concen. Details
unknown
109 o-Chlorotoluene
DP (Toluene, o-chloro-)
(C7H7CI)
000095498
(GR B)
Unknown
110 p-Chlorotoluene
DP (Toluene, p-chloro-!
(C7H7CI)
000106434
Ditto
111G Cresylie acid
(Cresol)
C6H4OHCE3
(C7HsO)
001319773
(QRX)
1454 rat
861 mus
LCLo:50 mg/kg,
orl-hmn
Corrosive to skn
& mucous mem
Absorption may
result in kidney,
liver & CNS
damage
USDS air: TWA
5 ppm (skn) or
22 mg/m3
116
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Intermediate in organic 2)642
synthesis, e.g., drugs; 3)497
fire retardant phenolic 12)
resins
Chlorination
(Phenol, chlorine,
sodium carbonate,
hydrochloric acid)
298 Water: NaCI, HCI,
phenol, chlorine,
chlorophenols
Air: C\2, HCI, solvent
Emission factors:
Cl2 - 2.0, carbon
tetrachloride - 1.0,
phenol - 1.0
Dye intermediate;
synthesis higher
chlorophenols
1)705
2)642
3)497
C ilorination 298
(Phenol, chlorine
sodium carbonate.
hydrochloric acid)
Sandmeyer 344
Reaction,
Replacement
(m-toluidine.
sodium nitrate.
hydrochloric acid.
duprous chloride)
Chlorination 345
(Toluene,
chlorine.
iron catalyst)
Chlorination 345
(Toluene,
Chlorine, iron
catalyst)
Springing & 78
Separation
Ditto —
Air: HCI, NOX
Water: HCI, m-toluidine
hydrochloride, copper
salts m-chlorotoluene
Air: Cl2, HCI, Toluene —
Water: NaOH, NaCI,
dichlorotoluenes
Ditto —
Emission factors: —
NO2 - 4.2, hydro-
carbons - 2.0
Water: caustic.
phenols and
cresols
— Intermediate synthetic
dyes & drugs; alcohol
denaturant; selective
solvent mineral oil
refining
— Solvent; intermediate
— Solvent & intermediate
for organic chemicals &
dyes
— Ditto
78.6/1 973 22% phosphate esters;
65.0/1 978 1 5% phenol ic resins; 1 5%
laminates coatings for
magnet wire for small
electric motors; 1 5%
antioxidants; 6% dis-
infectants; 6% ore
flotation agent; organic
intermediate; wire enamel
solvent; plasticizers;
gasoline additives metal
2)642
3)497
4)245
1)793
3)501
1)795
3)501
1)795
2)914
3)501
1)209
2)311
3)520
5)560
6) 620 A
12)
13)32
117
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
111G (Continued)
111G Cresols, m&p
(QR X)
111 m-Cresol
DP (CyHsO)
1 1 2 o-Cresol
DP (C7H80)
1 1 3 p-Cresol
DP (C7HsO)
000108394 242 rat
(QRC) 2)311
311
1350 rat
4)293
344 mus
LDLo:940
rbt
000106445 207 rat
(QRD) 2I311
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
cleaning compounds, sur-
factants, oil additives,
solvent refining of lubri-
cating oils, scouring com-
pounds, pesticides
See item above
See item
above
See item above
41.8/1973 Similar to cresylic acid
1)209
12)
Vapor phase
methylation
(Phenol, methanol,
Al catalyst)
82 Air & Water: cresols,
phenol, methanol
Total m. Similar to cresylic acid; 1)217
o, p-cresol disinfectant; phenolic 2)311
52.4/1973 resins; tricresyl phos- 3)520
phate; ore flotation; 4)293
textile scouring agent; 5)560
organic intermediate; 61620A
manufacture of sali- 7)6-442
cyladehyde, coumarin, 12)
& herbicides, food anti-
oxidants; surfactant;
molding compounds;
adhesives
See Cresylic Acid
78 See Cresylic Acid
11.2/1973 Similar to cresylic acid;
organic synthesis sali-
caldehyde, coumarin,
miscellaneous
1)209
2)311
3)520
4)293
5)560
See m-cresol
82
See m-cresol
1)217
See m-cresol
82
See m-cresol
11.2/1973 Similar to cresylic acid
1)209
2)311
3)521
4)293
5)560
119
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
113 (Continued)
DP
LD50:750 mg/kg,
skn-rat
LDLo: 150 mg/kg,
scu-mus
LDLo:80 mg/kg,
scu-cat
LD50:301 mg/kg,
skn-rbt
LDLo:300 mg/kg,
scu-rbt
LDLo:180 mg/kg,
ivn-rbt
114 Crotonaldehyde
CH3CHCHCHO
000123739
(VH1U2-T)
300 rat TCLo:12 mg/m3/
240 mus 10M
TFX:IRR, ihl-hmn
Lachrymator;
strong irr; may
cause corneal burns
LC50:4000 mg/m3/
30M, ihl-rat
LD50:140 mg/kg,
scu-rat
LC50:1510mg/m3/
2H, ihl-mus
LD50:140 mg/kg,
scu-rat
LD50:30 mg/kg,
skn, gpg
115
Crotonic acid
CH3CHCHCOOH
(C4H602)
003724650
(QV1U2-T)
1000 rat
4800 mus
Unknown
LD50-.600 mg/kg,
skn-gpg
LD50:100 mg/kg
ipr-rat
116 Cumene
C6H5CH(CH3)2
(CgH12)
000098828
(1 YR)
1400 rat Potent narcotic with
2)316 long-duration effects.
2910 rat CNS depressant.
4)298 Possible cumulative
effects
LC50:8000 ppm/4H,
ihl-rat
LCLo:2000 ppm,
ihl-mus
USOS air: TWA
50 ppm (skn) or
245 mg/m3
120
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Sulfonation
(Toluene, sulfuric
acid, caustic soda)
80 Air & Water: Sulfuric
acid and cresol
Water:
Flow (10.8 I/kg)
COD (23,800 mg/l)
(256 g/kg/
BOD5 (11,400 mg/l)
(123 g/kg)
TOC (5,020 mg/l)
(54 g/kg)
1)213
Oxidation
(p-cymene,
caustic soda,
sulfuric acid)
Air: p-cymene,
acetone
Water: p-cresoi,
acetone, sodium
hydroxide
1)215
Dehydration
(Acetaldehyde,
caustic soda,
acetic or
phosphoric acid)
87 Water: acetaldehyde,
acetadol, crotonald-
ahyde, byproducts
Emission factors:
acetaldehyde -
1.00
Heavy ends
incinerated
Intermediate for n-butyl 1 )243
alcohol & 2-ethyl-hexyl 2)314
alcohol; solvent; prepara- 3)521
tion of rbr accelerators; 12)
purification of lubrica-
ting oils; insecticide; tear
gas; fuel-gas warning agent;
organic synthesis; leather
tanning; alcohol denaturant
Oxidation
(Crotonaldehyde,
air, copper/cobalt
acetate catalyst,
solvent
98
Synthesis of resins, 1 )266
polymers, plasticizers, 2)314
drugs; adhesive for book- 3)521
binding; sizing & sealing 7)6-167
of wood; molding; drying
oil; fungicide; coatings
Alkylation
(Benzene, pro-
pylene, phosphoric
acid catalyst)
36 Water: 1-4% of the
product steam
Air: Cumene, acetone,
trace mesityl oxide
1210/1973 Synthesis: 65% phenol, 1)120
1325/1974
895/1975
1482/1978
34% acetone, 1%a!pha-
methylstyrene, cumene
hydroperoxide; solvent
blending of fuels
2)316
3)522
4)298
5)560
6)650
7)6-546
13)32
121
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
UD50, mg/kg
Toxicology
TLV
Carcinogen
117 Cumene hydroperoxide 000080159
(Hydroperoxide, (QOXR)
a,a-dimethylbenzyl)
(CH3)2C(C6H5)OOH
(C9H1202)
382 rat
LDLo:5000
LC50:220 ppm/4H,
ihl-rat
LD50:95 mg/kg,
ipr-rat
LD50:400 mg/kg,
scu-rat
LD50:200ppm/4H,
ihl-mus
LDLo:90 mg/kg,
ipr-mus
TDLo:304 mg/kg,
TFX:NEO, ihl-mus
TDLo:10gm/kg/
76WI,TFX:NEO,
scu-mus
118 Cyanoacetic acid
(Acetic acid, cyano-)
CNCH2COOH
(C3H3N02)
000372098
(QV1CN)
Highly toxic
LD50:200 mg/kg,
ipr-mus
LDLo:2000 mg/kg,
scu-rbt
119 Cyanogen chloride
CNCI
(CCIN)
000506774
(GCN)
TCLo:10mg/m3
ihl-hmn
Highly toxic
LC50:118ppm/30M,
ihl-rat
LC50:117ppm/30M,
ihl-mus
LDLo:39 mg/kg,
scu-mus
LCLo:800 mg/m3/
7.5M, ihl-dog
LDLo:5 mg/kg,
scu-dog
LDLo:20 mg/kg,
scu-rbt
120 Cyanuricacid
(S-Triazine-2,4,4-triol)
000108805 LDLo:500
(T6N CN ENJ
BQ DQ FQ)
rat
Highly toxic
TDLo:55gm/kg/
82WI
TFX:NEO,orl-rat
TDLo:27gm/kg/
2 Yl
TFX:NEO, scu-rat
122
-------
Process
(Sources Process
of Compound) No.
Oxidation, 294
Peroxidation
(Cumene, air
sodium carbonate.
sodium stearate)
Associated Wastes
Water: Plant 1:
Flow -2.33x TO'3
m3/kg
COD - 4,700 mg/l
11.1g/kg
BOD5- 2,410 mg/l
5.6 g/kg
TOC- 194 mg/l
0.45 g/kg
Plant 2:
Fow- 1.37 x ID'3
m3/kg
COD - 84,304 mg/l
11. 4 g/kg
BOD5- 17,575 mg/l
24 g/kg
TOC - 77,406 mg/l
105.6 g/kg
Total
Waste Production
Treatment kg/year Uses References
— — Production of acetone 1)697
& phenol; polymerization 2)471
catalyst, particularly 3)523
in redox systems, used
for rapid polymerization
Substitution
(Sodium salt of
chloroacetic acid,
sodium cyanide)
111 Water: chloroacetic
acid, sodium cyanide,
cyanoacetic acid,
byproducts
Organic synthesis
1)296
2)18
3)526
Chlorination
(Hydrogen
cyanide, chlorine)
168 Air: chlorine, HCN,
NCCI
Water: hydrogen
cyanide, NaOH, NaCI
Organic synthesis; tear 1 )428
gas; warning agent in 2)317
fumigant gases 3)527
Thermal decom-
position,
condensation
(Urea)
186 Air: ammonia
Water: solvents, acids,
byproducts
Organic synthesis
1)467
2)927
3)528
123
-------
TABLE A-1. (Continued)
Item
No.
121
DP
Compound
Name and
Formula
Cyanuric chloride
(S-Triazine-2,4,6-
trichloro-)
(C3CI3N3)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50,mg/kg Toxicology TLV
000108770 485 rat Irr to mucous mem; —
(T6N CN causes heart erhythmia
ENJBG inhmns
DG FG)
Carcinogen
TDLo:18mg/kg/
73W,TFX:NEO,
unk-rat
TDLo:22 gm/kg/
82WI,TFX:NEO,
orl-rat
TDLo:750 mg/kg/
15WI
TFX:NEO, scu-rat
122
Cyclohexane
(C6H12)
000110827
(L6TJ)
29,820 rat
1297mus
LDLo:5500
rbt
LDLo:500 mg/kg
orl-hmn
skn irr
asphyxiant
LDLo:77 mg/kg,
ivn-rbt
USDS air: TWA
300 ppm or
1050 mg/m3
123 Cyclohexanol
CgHiiOH
(C6H120)
000108930
(L6TJ AQ)
2060 rat
LDLo:1300
dog
LDLo:2200
rbt
Ditto
Ditto
Ditto
LDLo:500 mg/kg,
orl-hmn
TCLo:75 ppm,
TFX:IRR,ihl-hmn
Narcotic; kidney,
liver & blood
vessel damage in
experimental
animals
LCLo:800 mg/kg,
scu-cat
LDLo: 1420 mg/kg,
ipr-rbt
Ditto
USDS air: TWA
50 ppm or 200
mg/m^
Suspected
carinogen
Ditto
Ditto
124
DP
Cyclohexanone
CO(CH2)4CH2
(C6H100)
000108941
(L6VTJ)
1620 rat
LDLo: 1300
mus
LDLo: 1600
rbt
TCLo:75 ppm,
TFX:IRR, ihl-hmn
Death after long
exposure. Irr to
eyes & throat;
mild narcotic
LCLo:2000 ppm/
4H, ihl-rat
USDS air: TWA
50 ppm or 200
124
-------
Process
(Sources
of Compound)
. Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Trimerization
(Cyanogen chloride)
169 Air: cyogen chloride,
byproducts
Chemical synthesis; dye- 1 )430
stuffs; Pharmaceuticals; 2)927
explosives; surfactants 3)528
8)312
Hydrogenation
(Benzene, hydrogen,
Pt or Ni catalyst
with Li salt on
alumina)
44 Air: benzene,
hydrogen, sulfur,
CO
Water: COD given
Emission factors:
CO - 25.0, hydro-
carbons - 20.0,
S02 - 2.0
Solvent extrac- 965/1973 Manufacturing: 48% 1)137
tion columns 1063/1974 nylon 66, 18%capro- 2)319
and strippers 1061/1978 lactam; solvent for 3)529
cellulose ethers, fats, 5)560
oils, waxes, bitumens, 6)620B
resins, crude rubber; 12)
extracting essential oils; 13)32
chemicals (organic
synthesis, recrystallizing
medium),-paint &
varnish remover
Oxidation
(Cyclohexane, air,
boric acid or
cobalt naphthenate
catalyst)
46
Air: cyclohexane,
residual crude,
catalyst salts
325.5/1968
Manufacturing: 90%
adipic acid for nylon;
soap making; solvent for
phenolic insecticides;
textile finishing solvent;
blending agent; solvents
for lacquers; paints &
varnishes; finish removers;
dry cleaning; emulsified
products; leather degreas-
ing; polishes; plasticizers;
plastics; germicides
1)143
2)326
3)529
5)560
Hydrogenation
(Phenol, hydrogen,
benzaldehyde,
sodium hydroxide
304 Air: phenol, cyclo-
hexanol, cyclo-
hexanone
Water: NaOH,
benzaldehyde,
cyclohexanone,
condensation
products
— Ditto
Ditto
1)717
Oxidation
(Cyclohexanol,
air, cobalt
naphthenate
catalyst)
46 See Cyclohexanol
289.7/1973 Organic synthesis: parti- 1)143
cularly of adipic acid & 2)327
caprolactam (about 95%); 3)529
polyvinyl chloride & its 5)560
copolymers, & meth- 6)621
aery late ester polymers; 12)
solvent for DDT in
aerosol bombs; general
(Continued)
125
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
124 (Continued)
DP
LD50:1350 mg/kg,
ipr-mus
LDLo:630 mg/kg,
ivn-dog
LD50:1000 mg/kg,
skn-rbt
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
125 Cyclohexene
CHCH
(C6Hio>
000110838
(L6UTJ)
USDS air: TWA
300 ppm or
1015mg/m3
126
DP
Cyclohexylamine
(C6H13N)
000108918
(L6TJ AZ)
710 rat
LDLo:50 my/kg,
orl-hmn
Dermatitis & con-
vulsions
LCLo:8000 ppm/
4H, ihl-rat
LD50:200 mg/kg,
ipr-rat
LD50.-300 mg/kg,
ipr-mus
LD50:320 mg/kg,
skn-rbt
USDS air: TWA
10 ppm (skn) or
40 mg/m3
Ditto
Ditto
Ditto
Ditto
Ditto
126
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Oxidation 305 Air: Cyclohexane, cyclo- —
(Cyclohexanol, hexanol, cyclohexanone
air, copper Water: NaOH, dissolved
catalyst) organics
Hydrogenation 306 Air: cyclohexanol, Scrubber
(Phenol, Pd on cyclohexanone
carbon Water: phenol, cyclo-
catalyst) hexanol, cyclohexanone
Emission factors:
CO - 1115, hydro-
carbons - 100.7
See item
above
Ditto
wood stains; paint &
varnish removers; spot &
stain removers; degreas-
ing of metals; in polishes;
leveling agent in dyeing
& delustering silk; lube
oil additive; general
solvent
Ditto
Ditto
1)719
1)720
Dehydration or
halogenation and
dehydrohalogena-
tion
(Cyclohexanol and
A^Os or H3PO4
catalyst or cyclo-
hexanol or cyclo-
hexene, halogen
and zeolite/alkali
oxide catalyst)
47
965/1973
1068/1974
805/1975
Inorganic synthesis;
catalyst solvent; oil
extraction
1)145
2)328
3)530
5)560
Reduction
(Aniline,
hydrogen, Ru or
Raney nickel
catalyst)
20
Air: aromatics,
hydrogen
Emission factors:
cyclohexanol - 1.0
Boiler-water treatment;
corrosion inhibitor in
boilers; rubber accelera-
tor; intermediate
1)85
2)329
3)530
5)560
12)
Reduction amina-
tion (Cyclohexanone,
ammonia, hydrogen,
Ni catalyst)
48 Air: hydrocarbons
Water: nickel
compounds
Ditto
1)147
(Continued)
127
-------
TABLE A-1. (Continued)
Item
No.
127
Compound
Name and
Formula
Decahyd ronaphtha lenes
(Naphthalene,
decahydro-)
(C10H18)
Chem. Abstr.
Registry No.
(WLN)
000091178
(L66TF)
Oral Toxicity,
LDg0, mg/kg Toxicology TLV
41 70 rat TCLo:100ppm —
TFX:IRR,ihl-hmn
Irr to eyes, skn, &
muc mem. Kidney
damage in experi-
mental animals
LCLo:500 ppm/
2H, ihl-rat
Carcinogen
1 28
Decanol
(n-decyl alcohol)
000112301
(Q10)
-------
Process
(Sources
of Compound)
Hydro genation
(Naphthalene,
hydrogen, Cu or
Ni catalysts)
Process Waste
No. Associated Wastes Treatment
216 Air: hydrogen, —
naphthalene, hydro-
genated naphthalenes
Emission factors:
CO - 3.0, hydro-
carbons - 2.0
Total
Production
kg/year Uses
— Solvent for oils, fats,
waxes, resins, rubber,
etc.; substitute for
turpentine; cleaning
machinery; stain-
remover; shoe creams,
floor waxes, etc.;
cleaning fluids;
lubricants
References
1)531
2)571
3)536
12)
None
Plasticizers; deterigents; 2)339
synthetic lubricants; 3)536
solvent; perfumes; 7)1-557
flavorings; softner for
compounding rubber
Aldol
condensation
(Acetone, alkali
or alkaline earth
catalyst)
257
Air: acetone,
diacetone alcohol
Solvent for nitrocellu- 1 )627
lose, cellulose acetate, 2)621
various oils, resins, waxes, 3)539
fats, dyes, tars; lacquers; 5)560
dopes; coating composi-
tion; wood preservatives;
stains; rayon & artif ical
leather; imitation gold
leaf; dyeing mixtures; anti-
freeze mixtures; extraction
of resins & waxes; preserva-
tive for animal tissues;
metal-cleaning compounds;
hydraulic compression fluids;
stripping agent (textiles);
laboratory reagent; the
technical grade, containing
acetone, has greater solvent
power
Reduction
(3,5-Dinitrobenzoic
acid, hydrogen, Pd,
Cu, Pt or Ni
catalyst)
328
Air: low boiling
organic nitrates
Water: reactant
and product
1)765
3)541
(Continued)
129
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
Diaminotoluenes
(2,4 and 2,6),
see 382
131G
DP
Dichloroanilines
(2,5 and 3,4
isomers)
(8 isomers
possible)
(ZR XG XG)
131
Aniline, 3,4-
dichloro-
CI2C6H3NH2
(C6H5Cl2N)
000095761
(ZR CG DG)
648 rat TCUo:0.025 mg/kg
740 mus TFX:EYE, ihl-hmn
Forms methemoglobin
with anoximia & CNS
depression; possible
blood pressure lower-
ing & cardiac arrhythmia
LD50:700 mg/kg,
skn-cat
132
Aniline, 2,4-
dichloro-
000554007 LDLo:113
(ZR BG DG)
cat
Forms methemoglobin
with anoximia & CNS
depression; possible
blood pressure
lowering & cardiac
arrhythmia
133G
Dichlorobenzenes
(o,p)
(GR XG)
133 o-Dichlorobenzene
DP (benzene, o-
dichloro)
000095501
(GR BG)
500 rat
500 rbt
LDLo: 2000
gpg
LDLo:500 mg/kg,
orl-hmn
Irr to skn & muc
mem. Liver &
kidney damage
produced experi-
mentally
LCLo:821 ppm/7H,
ihl-rat
USDS air: TWA
CL 50 ppm or
300 mg/m3
130
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Reduction
(Dichloro-
nitrobenzene,
iron, HCI)
11
Water: acid
Dye intermediate; 1)71
intermediate for 2)95
biologically active 3)557
compounds; herbicides
Ditto
Ditto Ditto
Ditto
Ditto
2)94
3)557
Chlorination
(Chlorobenzene,
ferric chloride,
chlorine)
Emission factors:
benzene - 22.6,
chlorobenzene -1.3
p-dichlorobenzene -
0.05
o-dichlorobenzene -
0.05
63.4/1972 Solvent for organic 1)57
30.0/1973 material & for oxides of 2) 159
nonferrous metals; fumi- 3)557
gant & insecticides, de- 5)560
greasing hides & wool; 9)22
metal polishes, industrial
odor control; germicide
space odorant; manu-
facture of 2,5-dichloro-
aniline; dyes; intermediates,
Pharmaceuticals, agricu-
ture (fumigating soil)
Ditto
Ditto Ditto
Ditto 53% organic synthesis,
mainly 3,4-dichloro-
aniline; 20% solvent,
toluene diisocyanate
synthesis; 15% solvent
(paint remover, engine
cleaner); 8% dye manu-
facturing; 4% other,
e.g., pesticide manu
manufacturing.
2)159
3)557
12)
13)33
(Continued)
131
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
133 (Continued)
DP
LDLo:400 mg/kg
ivn-mus
LDLo:250 mg/kg,
ivn-rbt
LCLo:800ppm/24H,
ihl-gpg
134 p-Dichlorobenzene
DP (C6H4CI2)
000106467
(GR DG)
500 rat
2950 mus
LDLo:2500
9P9
TDLo:300TFX:
UNS, orl-hmn
LD50:2500 mg/kg,
ipr-rat
USOSainTWA TDLo: 142 mg/kg/
75ppmor450 I,TFX:CAR,
mg/m3 scu-mus
— m-Dichlorobenzene
135 Dichlorodifluoro-
methane
(Methane, dichloro-
difluoro-)
Freon 12
000075718
1,2-Dichloroethane,
see 204
Narcotic in high
concentrate
USDS air: TWA
1000ppm
136
1,2-Dichloroethylene,
cis
000540590
(G1U1G)
Narcotic & irr
produced liver
& kidney injury
in experimental
animals
USDS air: TWA
200 ppm
1,2-D ich loroethy lene,
trans
770 rat TCLo:4800mg/
m3/10M
TFX:CNS, ihl-hmn
1,1 -Dichloroethylene,
see 405
132
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
See item above
See item above
28.5/1973
50% space deodorant;
40% moth control;
synthesis 2,5-
dichloroaniline;
miscellaneous
1)57
2)159
3)557
5)560
6)617
8)52
9)22
13)33
Isomerization
(AICI3 & HCI
catalysts)
5A
1)57
Substitution,
Fluorination
(Carbon tetra-
chloride,
HF,SbCl3
catalyst)
163 Water: HCI, sodium
hydroxide, HF
Air: chlorofluoro-
hydrocarbons
Emission factors:
Dichlorodifluoro-
methane - 5.0,
CCI4 - 4.0, HCI -
3.0, HF-3.0,
trichlorofluoro-
methane • 1.0
222/1973 52% aerosols, 29% re- 1 )417
233.8/1974 f rigerants, 9% foam 2)537
blowing agent 3)560
6)631B
12)
13)33
Low temperature & 3)561
special purpose solvent, 5)560
e.g., extraction of heat
sensitive substances
(Continued)
133
-------
TABLE A-1. (Continued)
Item
No.
137
Compound
Name and
Formula
Dichloroethyl ether
(Ether, bis(2-chloro-
ethyl)
CICH2CH2OOH2CH2C
(C4HsCl2O)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
000111444 75 rat
(G202G) 4)352
105 rat
;i 2)410
Toxicology
Irr to muc mem of
the eyes & nose;
mild narcotic; effects
kidneys & liver in
varying degree
LCLo:1000ppm/
45M, ihl-rat
LD50:300 mg/kg.
skn-gpg
TLV Carcinogen
USDS air: CL TDLo:33gm/kg/
15ppm(skn) 79 WIC,TFX:CAR ,
or 90 mg/m3 orl-mus
— Dichloromethyl ether,
see 26ADD
000542881
(G101G)
210
USDS;
carcinogen
Known
carcinogen
138 Dichlorohydrin
(2-Propanol, 1,3-
dichloro-)
CH2CICHOHCH2CI
(C3H6CI20)
00096231
(G1YG1G)
490 rat Irr to muc mem
LCLo:125ppm/4H,
ihl-rat
LD50:800 mg/kg,
skn-rbt
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Dichloronitrobenzenes
(3,4- and 2,5-dichloro-
1-nitrobenzene), (see
also Items 284 and 286,
Table B-2, Dye
Intermediates)
1210 rat
(2,5
isomer)
139 Dichloropentanesi
(Pentane, 1,5-dichloro-)
(C5H10CI2)
000628762
Unknown
134
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment kg/year
Chlorination 142 Air: ethyl ether, HCI scrubber —
(Ethyl ether, chlorine, HCI, di-
chlorine, catalyst) chloroethyl ether
Uses
Soil fumigant; general
solvent; selective solvent
for production of high-
grade lubricating oils;
textile scouring &
cleansing; fulling com-
pounds; wetting &
pentrating compounds;
organic synthesis; paints.
varnishes, lacquers, -finish
removers; spotting & dry
cleaning; war gas
References
1)369
2)410
3)562
4)352
5)560
7)8-477
Substitution,
Chlorination
(Glycerol, HCI,
4% acetic acid)
253 Water: acetic acid,
acetates, dichloro-
hydrin, halides
General solvent; inter-
mediate in organic
synthesis; paints, var-
nishes, lacquers, cellu-
loid cements; water
colors' binder; photo
lacquers
1)620
2)759
3)566
Chlorination
(Ally! alcohol,
chlorine)
290 Air: allyl alcohol,
chlorine, dichloro-
hydrin, propylene
dichloride
Ditto
1)689
Addition, chloro-
hydrination
(Allyl chloride,
chlorine)
290 Air: allyl chloride,
chlorine, dichloro-
hydrin, propylene
dichloride
Ditto
1)689
Nitration
(1,2-and 1,4-
dichlorobenzene,
nitric acid,
sulf uric acid)
10 Water: Chlorinated
benzenes, chloro-
nitro phenols, acids
Dye intermediates
1)68
2)159
See amyl
chlorides
242
Solvent for oils, greases,
rubber, resins & bitumi-
nous material; removal of
tar; reclaiming rubber;
paint & varnish removers;
degreasing of metals;
insecticide; soil fumigant;
removal of wax deposits
on oil-well equipment
1)588
3)564
(Continued)
135
-------
TABLE A-1. (Continued)
Item
No.
140G
Compound
Name and
Formula
Dichloropropenes
(5 isomers)
Chem. Abstr.
Registry No.
(WLN)
001319682
(201 YG YG)
Oral Toxicity,
LDgQ, mg/kg Toxicology
—
TLV Carcinogen
—
140 1,3-Dichloropropene 000542756 250 rat
(Propene, 1,3-Dichloro-)
CHCICCICH3
(C3H4CI2)
Narcotic; degenera-
tive changes in liver
& kidneys
LDLo:260 ppm,
ihl-rat
141 Dicyclohexylarnine
(Hexylamine, dicycio-)
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
kg/year
Uses
References
Chlorination
See ally I chloride
(Propylene,
chlorine)
323 Air: Propylene
Water: Caustic soda
Absorber
Organic synthesis; soil
fumigants
1)750
2)765
3)567
Hydrogenation
(Aniline, hydrogen,
Ni catalyst)
49 Air: Hydrocarbons
Intermediate; insecticide; 1)149
plasticizer; corrosion in- 2)362
hibitor; antioxidants in 3)568
rubber; lubricating oils, 7)2-125
fuels; catalysts for paint, 8)130
varnishes & inks; deter- 9) 130
gents; extractant in
medicine; soaps & deter-
gents in textiles &
printing
See cyclohexylamine 48
1)147
Ammonolysis,
Amination
(Ethylene oxide,
ammonia)
152
Air: ammonia,
various ethanol-
50.4/1974 Liquid detergents for
48.3/1973 emulsion paints, cutting
oils, shampoos, cleaners,
& polishers; textile
specialties; absorbent for
acid gases; chemical inter-
mediate for resins &
plasticizers, etc.;
solubilizing 2,4-D
1)386
2)406
3)571
6)622
Amination
(Ethyl alcohol,
ammonia)
120 Air: ammonia, ethyl
alcohol, ethylamines
Water: organic & in-
organic ammonia
salts & above
Emission factors:
hydrocarbons - 2.0,
NH3-2.0
Stripper 5/1972 Rubber chemical; textile 1)316
specialties; selective 2)365
solvent; dyes; flotation 3)572
agents; resins; pesticides; 5)560
polymerization inhibitor; 7)2-123
Pharmaceuticals; 12)
petroleum chemicals;
electroplating; corrosion
inhibitor
Hy drat ion
(Ethylene oxide.
water, H2SO4
catalyst is
optional)
144 Air: ethylene glycol, —
ethylene oxide.
aldehydes
Water:
Flow - 4.873 m3/Mg
COD - 8.66 kg/Mg
122.0/1973 Manufacturing: 30% poly-
140.5/1974 urethane & unsaturated
polyester resins, 13%
triethylene glycol, 12%
textile softener, 7%
petroleum solvent
extractions, 7%
1)374
2)365
3)575
6)628
7)8-553
12)
13)33
(Continued)
137
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
144 (Continued)
Ditto Ditto Ditto Ditto — Ditto
145 Diethylene glycol 000112732 3900 rat Unknown
dibutyl ether (4020204)
(Ether, bis(2-butoxy-
ethyl)
(Dibutyl Carbitol)
146 Diethylene glycol 000112367 4970 rat Unknown
diethyl ether (2020202) 1850gpg
Ether, bis (2-ethoxyethyl)
Diethyl Carbitol
(C2H5OCH2CH2)20
(C6H1803)
147 Diethylene glycol 000111966
dimethyl ether (1020201)
(Ether, bis(2-
methoxyethyl-))
(Dimethyl Carbitol)
CH3O(CH2CH20)2CH3
(C6H1403)
148 Diethylene glycol 000112345 6560 rat LDLo:500 mg/kg,
monobutyl ether (Q20204) 2000 gpg orl-hmn
(Ethanol, 2(2-butoxy- LD50:850 mg/kg,
ethoxy)) ipr-mus
(Butyl Carbitol) LD50.-4120 mg/kg,
C4HgOCH2CH2OCH2CH2OH skn-rbt
(CsHioO-j)
138
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
BOD - 0.34 kg/Mg
TOC - 4.53 kg/Mg
dehydration of natural
gas, 7% plasticizers &
surfactants, solvent for
nitrocellulose, & many
dyes & oils; humectant
for tobacco, casein,
synthetic sponges, paper
products; cork composi-
tions; book binding
adhesives; dyeing assistant;
cosmetics; lubricants;
brake fluids; printing inks;
low-pressure laminates
Condensation &
reduction
(Formaldehyde,
CO, water, BF3 &
CuO+MgO
catalysts)
203 Air: CO
Water: Glycolic acid ,
formaldehyde,
methanol, higher
alcohols, organic
acids
Ditto
1)504
Alkoxylation
(Mono-, di-, or
triethylene glycol
monoether,
sodium salt, alkyl
chloride)
150 Water: NaCI, alkyl
chlorides, other
High-boiling, inert solvent
with application in ex-
traction processes & in
coatings & inks; diluent
in vinyl chloride disper-
sions; extractant for
uranium ores
1)384
2)410
3)575
Seediethylene
glycol dibutyl
ether
150
Solvent for nitrocellulose; 1)384
resins, lacquers; high- 2)411
boiling medium & solvent 3)575
for organic synthesis
Ditto
Ditto
Solvent; anhydrous re- 1 )384
action media for organic 3)575
metallic synthesis
Alkoxylation
(Ethylene oxide,
alcohols)
149 Water: ethylene oxide,
ethylene, higher poly-
glycols, alcohols,
glycol monoethers
11.5/1973 Manufacturing: Acetate 1)381
ester for solvent use; 2)401
coalescing agent latex 3)444
paint; solvent for nitro- 6)636
cellulose, oils, dyes, gums, 13)34
soaps, polymers; plastici-
zer intermediate
(Continued).
139
-------
TABLE A-1. (Continued)
Item
No.
149
Compound
Name and
Formula
Diethyleneglycol
monobutyl ether
acetate
(Ethanol, 2- (2-
butoxy-ethoxy)-
acetate)
(Butyl Carbitol acetate)
C4HgO(CH2)2O(CH2b<
Chem. Abstr.
Registry No.
(WLN)
00012174
(402020V 1)
DOCCH3
Oral Toxicity,
LDgn, mg/kg Toxicology TLV Carcinogen
6500 rat LD50: 15,000 mg/kg,
2)401 skn-rbt
12,000 rat
3)444
6600 mus
2600 rbt
2340 gpg
5000 ckn
150 Diethyleneglycol
monoethyl ether
(Ethanol, 2(2-ethoxy-
ethoxy)
(Carbitol)
(C6H1403)
000111900
(Q20202)
6500 rat
3620 rbt
3670 gpg
LDLo:500 mg/kg,
orl-hmn
LDLo:2000 mg/kg,
scu-rat
LDLo:2400 mg/kg,
ivn-rat
LD50:5638 mg/kg,
scu-mus
LD50:3900 mg/kg,
ivn-mus
151 Diethyleneglycol
monoethyl ether
acetate
(Ethanol, 2-(2-ethoxy
ethoxy(-acetate)
(Carbitol acetate)
(C8H1604)
000112151
(202020V1)
3930 gpg
11,000 rat
LDLo:500 mg/kg,
orl-hmn
152 Diethyleneglycol
monohexyl ether
(Ethanol, 2(2-hexyl-
oxy)ethoxy-1)
(Hexyl Carbitol)
CeH 130(CH2:itO(CH2)20H
000112594
(Q20206)
4920 rat
LD50:1500 mg/kg,
skn-rbt
153 Diethyleneglycol 025961891
monohexyl ether ac (202060V 1)
acetate
(Ethanol, 2 [2- [2-
(hexyloxy ethoxy
acetate)
(Hexyl Carbitol acetate)
CeH 130 (CH2)2O(CH2>2OOCCH3
140
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Esterification 151
(Mono- or diethylene (see
glycol monoether, also
acetic acid) 145)
Water: Reactants and
products
Separator
Solvent for oils, resins, 1 )385
gums, also for cellulose 2)401
nitrate & polymeric coat- 3)444
ings; plasticizers in
lacquers & coatings
See diethylene
glycol mono-
butyl ether
149
— 12.6/1973
Brake fluid diluent; coat-
ings solvent; textile print-
ing & drying solvent;
cosmetics & toiletries
solvent; solvent for dyes,
nitrocellulose, & resins;
nonaqueous stains for
wood; for setting the
twist & conditioning yarns
& cloth; textile soaps;
organic synthesis
1)381
2)405
3)468
6)636
13)34
See diethylene
glycol mono-
butyl ether
acetate
151
Solvent for cellulose 1)385
esters, gums, resins; coat- 2)405
ings & lacquers; printing 3)468
inks
See Diethylene
glycol mono-
butyl ether
149
1)381
2)406
See diethylene
glycol mono-
butyl ether
acetate
151
1)385
(Continued)
141
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDg0, mg/kg
Toxicology
TLV
Carcinogen
154 Diethylene glycol
monomethyl ether
(Ethanol, 2(2-methoxy-
ethoxy)-)
(Methyl Carbitol)
CH3OCH2CH2OCH2CH2OH
(C5H1203)
000111773
(Q20201)
4160 gpg
9210 rat
LD50:650 mg/kg
skn-rbt
155 Diethylene glycol
monomethyl ether
acetate
(Ethanol, 2(2-methoxy-
ethoxy) -acetate)
(Methyl Carbitol Acetate)
000629389 3460 gpg
(1V020201)
(C7H1404)
156
Diethyl sulfate
(Sulfuric acid,
diethyl ester)
(C2H5)2SO4
(C4H10048)
000064675
(20SW02)
647 mus
LDLo:750
rat
TDLo:85 mg/kg
(15D Preg),
TFX:TER, ivn-rat
LCLo:250 ppm/4H,
ihl-rat
LD50:350 mg/kg,
scu-rat
LD50:340 mg/kg,
ivn-rat
TDLo:85 mg/kg
(15Dpreg),
TFX:CAR, ivn-rat
TDLo:1900mg/
kg/81WI,
TFX:CAR, orl-rat
TDLo:800 mg/kg/
49WI,
TFX:NEO, scu-rat
157 Difluoroethane
(Ethane, difluoro-)
F2C2H4
(C2H4F2)
026497283
(FYF)
Irr to lungs;
narcotic in high
concentrate
158
Diisobutylene
(Pentene, 2,4,4-
trimethyl-)
(C8H16)
012002232
(1X1YU1)
Irr & narcotic in
high concern;
liver & kidney
damage in experi-
mental animals
159
DP
Diketene
(2-Oxetanone,
4-methylene)
(C4H402)
003068880
(T4VOY DHJ
CUD
560 rat
LDLo:800
mus
LCLo:20,OOOppm/
1H, ihl-rat
160
DP
Dimethylamine
(CH3)2NH
(C2H7N)
000124403
(1M1)
698 rat
316 mus
240 rbt
240 gpg
USDS air: TWA
10ppm or 18
mg/m3
142
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
See diethylene
glycol mono-
butyl ether
149
6.2/1973
Solvent; brake fluid
component; inter-
mediate
1)381
2)407
3)812
6)636
Ditto
151
— Solvent
1)385
2)407
3)812
Esterification,
Sulfation
(Ethylene, 96%
sulfuric acid)
125
Water and Air:
ethanol, sulfuric
acid, diethyl
sulfate, mono-
ethyl sulfate
Ethylating agent in
organic synthesis
1)328
2)885
3)582
4)361
8)298
Hydrofluorination,
Fluorination
(Acetylene, HF
BF3 catalyst)
175
Air: acetylene,
difluoroethane
32% Aerosol; 29% re- 1 )443
frigerant; 9% foam 3)583
blowing agent 13)34
Polymerization
(Isobutylene,
H2S04)
75
Water: sodium
hydroxide,
sodium sulfate,
butyl alcohol
Alkylation; intermediate; 1)200
antioxidants; surfactants; 2)622
lube additives; plastic!- 3)590
zers; rubber chemical
Pyrolysis &
Dimerization
(Acetone or
acetic acid)
2638
(see also
263A&
105)
See Ketene (263)
Production of acetoaryI- 1)639
amides; pigments & 2)617
toners; pesticides; food 3)593
preservatives; pharmaceuti-
cal intermediate
192
See Methylamine
(276DP)
55.2/1973 23% manufacture
dimethylformamide & di-
methylacetamide, about
7% lauryl dimethylamine
oxide (surfactant), about
7% rubber chemicals
1)481
2)367
3)595
5)560
9)200
13)34
(Continued)
143
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
160
DP
(Continued)
161 N.N-Dimethylaniline
DP (Aniline, dimethyl)
C6H6N(CH3):2
000121697
(1N1&R)
LDLo: 1410 rat
LDLo:50 mg/kg,
orl-hmn
LD50:1770 mg/kg,
skn-rbt
CNS depressant
USOS air: TWA
5 ppm (skn) or
25 mg/m3 (skn)
162
Dimethyl ether
(Methyl ether)
CH3OCH3
(C2H60)
000115106
(101)
163 N,N-Dimethyl-
formamide
(Formamide, N,N-di-
methyl)
(CH3)2NCHO
(C3H7NO)
000068122
(VHN1&1)
2800 rat
1122mus
4)376
3750 mus
2)429
LDLo:500 mg/kg,
orl-hmn
TCLo:20ppm,
TFX:CNS, ihm-hmn
Highly irritating;
prolonged ihl pro-
duced liver damage
in experimental
animals
LD50:1260 mg/kg,
ipr-rat
LD50:3500 mg/kg,
scu-rat
LD50:2350 mg/kg,
ivn-rat
USOS air: TWA
10 ppm (skn) or
30 mg/m3 (skn)
164
DP
Dimethyl sulfate
(Sulfuric acid,
dimethyl ester)
(CH3)2SO4
(C2H604S)
000077781
(10SW01)
440 rat LDLo:97 ppm/10M, USOS air: TWA
ihl-hmn 1 ppm (skn) or
Intense irr to skn & 5 mg/m3
muc mem; frequent
liver & kidney damage;
death may be delayed
for several weeks
TDLo:20 mg/kg/
(15D preg),
TFX:TER, ivn-rat
2)lists this data as CAR
TCLo:17mg/m3/
18WI,
TFX:CAR, ihl-rat
144
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
(antioxidants, accelera-
tors); dyes; about 23%
acid gas absorbent; solvent;
solvent; flotation agent;
gasoline stabilizers;
Pharmaceuticals; textile
chemicals; electroplating;
dehairing agent; missile
fuels; rocket propellents
Alkylation
(Aniline,
methanol)
13 Water: aniline
7.1/1973 Solvent; activator for
polyesters; alkylating
agent; dye intermediate;
stabilizer (acid
acceptor)
1)72
2)95
3)598
5)560
7)2-420
9)23
Condensation,
Dehydration
(Methanol, sul-
f uric acid or
alumina catalyst)
196 Water: traces of ether
aldehydes and
peroxides
Refrigerant; solvent;
extraction agent; pro-
pellant for sprays;
chemical (reaction
medium); catalyst &
stabilizer in
polymerization
1)491
2)550
3)605
Acylation
(Methyl formate,
dimethylamine)
200 Air: methyl formate,
dimethylamine,
methanol
Solvent for vinyl resins & 1 )496
acetylene, butadiene, 2)429
acid gases; catalyst in 3)606
carboxylation reactions; 4)376
organic synthesis 5)560
Ester ificat ion,
Sulfation
(Dimethyl ether,
liquid sulfur
trioxide)
197 Air: SOX
Water: sulfuric acid,
methyl hydrogen
sulfate
Methylating agent for
amines & phenols
1)493
2)885
3)613
5)560
(Continued)
145
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
164,
DP
(Continued)
LCLo:32 ppm/4H,
ihl-rat
LD50:100 mg/kg,
scu-rat
LCLo:75ppm/17M,
ihl-mus
165
Dimethyl sulfide
(Methyl sulfide)
(CH3)2S
(C2H6S)
000075183
(1S1)
535 rat
3700 mus
Unknown
LD50:8000 mg/kg,
ipr-mus
166 Dimethyl sulfoxide
(Methyl sulfoxide)
(CH3)2SO
(C2H6OS)
000067685
(OS1&1)
20,000 rat
21,000 mus
Freely penetrates skn;
skn irr; causes nausea,
chills, cramps, lithargy
TDLo:5gm/kg/
(6-12Dpreg),
TFX:TER, orl-rat
TDLo:8gm/kg/
(6-12D preg),
TFX:TER, ipr-rat
TDLo:50 mg/kg/
(8D preg),
TFX:TER, ivn-ham
LD50.-2500 ivn-dog
— Dimethyl terephthalate,
see 374
167G Dinitrobenzene
(3 isomers)
Pathological effects;
anemia; jaundice;
enlarged liver or
yellow atrophy,
kidney degenera-
tion; CNS injury
167 Benzene, m-dinitro 000099650 42 bdw
(WNR CNW)
TDLo:4 mg/kg/
2DI
TFX:BLD, skn-man
LDLo:27 mg/kg,
orl-cat
USDS air: TWA
1 mg/m3 (skn)
168 Benzene, p-dinitro
000100254 LDLo:29
(WNR DNW)
cat
USDS air: TWA
169 Benzene, o-dinitro
C6H4(N02)2
(C6H4N204)
025550554 29 cat
(ONR BNO)
146
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Substitution
(Methanol, carbon
disulfide, AI2O3
catalyst)
206 Air: carbon disulfide,
methanol, methyl
mercaptan, possible
H2S
Gas odorant; solvent for 1 )510
many inorganic sub- 2)550
stances; catalyst 3)832
impregnator; synthetic 7)9-354
flavor
Oxidation
(Dimethylsulfide,
nitrogen dioxide)
207 Air: CC>2, C>2, N2,
about 0.3% nitrogen
oxides (NOX)
Solvent for polymerization 1)511
& cyanide reactions; ana- 2)550
lytical reagent; spinning 3)613
polyacrylonitrile & other
synthetic fibers; industrial
cleaners pesticides, paint
stripping; hydraulic
fluids; preservation of cells
at low temperatures; diffusion
of drugs, etc., into blood
stream by topical application;
medicine; plant pathology &
nutrition
Nitration
(Nitrobenzene,
sulfuric acid,
nitric acid)
26 Air: NOX (0.1 kg/Mg
product)
Water: may be some
sulfuric acid, nitric
acid, mono-, &
dinitrobenzene
Organic synthesis; dyes; 11100
camphor substitute in 2) 160
celluloid production 3)616
2)160
3)616
5)560
Ditto
2)160
3)616
(Continued)
147
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
170G Dinitrobenzoic acid
(6 isomers)
015147645
(WNR XVQ
XNW)
170 Benzoic acid, 2,4-
dinitro
000610286
(WNR BVQ
ENW)
Benzoic acid, 2,6-
dinitro
000528450
(WNR BVQ
CNW)
Benzoic acid, 2,3-
dinitro
000610300
(WNR BVQ
FNW)
Benzoic acicl, 2,5-
dinitro
000603123
(WNR BVQ
DNW)
Benzoic acid, 3,4-
dinitro
(WNR CVQ
FNW)
171 3,5-dinitro-benzoic
acid
(Benzoic acid, 3,5-
dinitro-)
000099343
(WNR CVQ
ENW)
172G Dinitrotoluene
(6 isomers)
(WNR X
XNW)
USDS air: TWA
1.5 mg/m3 (skn)
172 Toluene, 2,3-dinitro
(WNR B
(C7H6N204) FNW)
1122 rat
Ditto
148
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10*> kg/year
Uses
References
Oxidation
(Toluene, nitric
acid, sulfuric
acid, chromic acid
or sodium
dichromate)
342 Air: NOX
Water: chromium or
potassium salts,
spent acid
1)789
Ditto
Ditto Ditto
Ditto
Ditto
Ditto Ditto
Ditto
Nitration 327 Air: SO2, NOX, CC>2
(Benzole acid. Water: nitric and
fuming nitric sulfuric acids, benzoic
and sulfuric acid, 3-nitrobenzoic
acids) acid, 3,5-dinitro-
benzoic acid
1)764
Nitration
(Toluene, nitric
acid, sulfuric
acid, nitro-
sylsulfuric acid)
340 Water: nitrated
toluene
Air: NOX, nitrated
toluenes
Emission factors:
Hydrocarbons -1.0,
NO2 - 0.3
237.6/1974
Organic synthesis;
toluidines; dyes;
explosives
1)785
2)914
3)619
12)
21914
(Continued)
149
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
173 Toluene, 2,4-dinitro
000121142
(WNR B
ENW)
268 rat
1625 mus
Anemia, muthermo-
globrinemia, cyanosic,
& liver damage
See item above
174 Toluene, 2,5-dinitro 000619158 707 rat
(WNRB 1231 mus
DNW)
Ditto
175 Toluene, 2,6-dinitro 000606202 177 rat
(WNRB 1000mus
CNW)
Ditto
— Toluene, 3,4-dinitro 000610399 177 rat
1414 mus
Ditto
176 Dioxane 000123911 4200 rat
(p-Dioxane) (T60 DOTJ) 2)369
OCH2CH2OCH2CH2 7100 rat
(C4H802) 3)620
2000 cat
2000 rbt
3150gpg
LDLo:500 mg/kg,
orMimn
TCLo:5500ppm/1M
TFX:EYE, ihl-hmn
LCLo:470 ppm,
TFX:UNS, ihl-hmn
Irr to eyes & nose,
followed by narcosis
and/or pulmonarye-
dima & death
LD50:790 mg/kg,
ipr-mus
USDS air: TWA TDLo:416 gm/
100 ppm (skn) or kg/57WC,
300 mg/m3 TF X: CAR, orl-rat
177 1,3-Dioxolane
OCH2CH2(
(C3H602)
000646060
(T50 COTJ
BY BYD1Q)
3000 rat LCLo:32,000 ppm/
7460 rat 4H, ihl-rat
178
DP
Diphenylamine
(C6H5)2NH
(C12HnN)
000122394
(RNR)
LDLo:3000
rat
LDLo:500 mg/kg,
orl-hmn
TDLo:7500 mg/kg/
(17-22Dpreg),
TFX:TER, orl-rat
10 mg/m3
Recognized
carcinogen
3)622
150
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
See item 172G
See
Item
172G
See Item 172G
1)785
2)915
2)915
See Item 172G
See
Item
172G
See Item 172G
1)785
2)915
2)915
Condensation,
dehydration
(Ethylene glycol,
sulfuric acid)
146 Water: sulfuric acid,
ethylene glycol,
dioxane
7.4/1973 Solvent for cellulosics
& wide range of organic
products; lacquers;
paints; varnishes; paint
& varnish removers;
wetting & dispersing
agent in textile pro-
cessing, dye baths, stain
& printing compositions;
cleaning & detergent pre-
paration; cements; cos-
metics; deodorants;
fumigants; emulsions;
polishing compositions;
stabilizer for chlorinated
solvent; scintillation
counter
1)378
2)369
3)620
5)561
9)199
Condensation
(Ethylene glycol,
formaldehyde)
147 Water: formaldehyde,
ethylene glycol,
dioxolane
Low-boiling solvent & 1)379
extractant for oils, fats, 2)370
waxes, dyes, & cellulose 3)621
derivatives
Condensation,
Dimerization
(Aniline, aniline
hydrochloride)
34
15.7/1973 Rubber antioxidants &
accelerators; stabilizers
for plastics & azo-dyes;
solid rocket propellants;
pesticides; explosives;
dyes; Pharmaceuticals;
anthelminthia &
insecticides
1)116
2)373
3)622
7)2-420
9)23
12)
(Continued)
151
-------
TABLE A-1. (Continued)
Item
No.
179
Compound
Name and
Formula
Diphenyl oxide
(Phenyl ether)
(C6H5)20
(Ci2Hi00)
Chem. Abstr.
Registry No.
(WLN)
000101848
(ROR)
Oral Toxicity,
LD50, mg/kg
3370 rat
Toxicology
Chronic damage to
liver, spleen, kidney,
thyroid, &GI
system; slight irr
TLV Carcinogen
USOS air: TWA
1 ppm or 7 mg/m3
180
Diphenylthiourea
(Carbanilide, thio)
(C13H12N2S)
000102089
(SUYMR
&MR)
1500rbt
LDLo:720
cat
Low toxicity
LD50:500 mg/kg,
ipr-mus
181 Dipropylene glycol
(2-Propanol, 1,1'-oxydi)
(CH3CHOHCH2)2O
(C6H1403)
000110985 15,000 rat
(QY&101
YQ)
182 Dodecene
(Propene, polymers,
tetramer)
(C12H24)
006842155
Unknown
183
DP
Dodecyaniline
(n-Dodecy (aniline)
C6H5HNC12H25
(C18H31N)
018686141
(ZR X12)
184G
Dodecylphenol
(Phenol, dodecyl)
HOC6H4C12H25
001331573 2140 rat
(OR X12)
LD: 5000 mg/kg,
skn-rbt
152
-------
Process
(Sources Process
of Compound) No.
Substitution, 52
Ullman reaction
(Chlorobenzene,
aqueous sodium
hydroxide)
Associated Wastes
Air: Chlorobenzene,
phenol
Water: NaOH, NaCI,
sodium phenoxide
Total
Waste Production
Treatment 106 kg/year
Uses
Organic synthesis; per-
fumery, particularly
soaps; heat-transfer
medium; resins for lami-
nated electrical
insulation
References
1)153
3)625
5)625
Condensation,
Acrylation
(Aniline, carbon
disulfide, alcohol,
sulfur, dilute
hydrochloric
acid)
32 Air: Carbon disulfide
Water: Aniline, aniline
oxidation products,
dilute acids and salts
Intermediates; dyes (sul-
fur colors, indigo,
methyl indigo); vulcani-
zation accelerator;
synthetic organic Pharm-
aceuticals; flotation agent;
acid inhibitors
1)112
2)279
3)1027
Hydration
(Propylene oxide)
287
Water: propylene
oxide, propylene
glycol
24.2/1973
Principally solvent un- 1 )684
saturated polyester resins; 2)761
solvent for nitrocellulose; 3)627
shellac; partial solvent for 9)204
cellulose acetate; solvent 13)35
mixtures; lacquers, coat-
ings; printing inks
Oligomerization 264
(Propylene/propane,
phosphoric acid)
Air: propylene,
nonene, dodecene,
other olef ins
Emission factors:
propylene -10.0
Principally synthetic dode- 1)640
cybenzene; flavors; per- 2)765
fumes; medicine; oils; 3)633
dyes; resins 12)
13)35
Alkylation
(Phenol, dodecene)
313
Water: phenol,
dodecylphenol
Intermediate
Solvent; intermediate for
surface-active agents; oil
additives; resins; fungi-
cides; bactericides; dyes;
Pharmaceuticals;
adhesives; rubber chemi-
cals; household &
industrial monionic
detergents
1)731
2)645
3)633
7)1-909
(Continued)
153
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD50, mg/kg
Toxicology
TLV
Carcinogen
185 Epichlorohydrin
(Propane, 1-chloro-
2,3-epoxy-)
C3H5OCI
(C3H5CIO)
000106898
(T30TJ
B1G)
90 rat
238 mus
LDLo:50 hmn
TDLo:20ppm,
TFXiEYE, ihl-hmn
Acute poisoning;
death may result
from respiratory
paralysis. Chronic
poisoning results
in kidney damage;
irr to skn
LCLo:250ppm/4H,
ihl-rat
LC100:7400ppm/
30M, ihl-mus
LD50:155 mg/kg,
ipr-mus
LD50:515 mg/kg,
skn-rbt, 2)744
LD50:1300 mg/kg,
skn-rbt, 3)641
USDS air: TWA
5 ppm (skn) or
19 mg/m3
TDLo: 19 mg/kg,
TFX:NEO, ihl-mus
TDLo:720 mg/kg/
18WI,TFX:NEO,
scu-mus
186
Ethane
(C2H6)
000074840
(2H)
Simple asphyxiant
187
DP
Ethanol
(Ethyl alcohol)
CH3CH2OH
(C2H60)
000064175
2 1000 rat
6300 rbt
5560 gpg
LDLo:2000
chd
LDLo:500
hmn
TDLo:50,
TFX:GIT
man
TDLo: 1.43
TFX:CNS
man
LDLo:220
mus
LDLo:5500
dot
LDLo:6000
cat
LDLo:6300
rat
No cumulative
effect; irr to eyes
& muc mem of the
upper respiratory
tract; repeated
ing can lead to
chronic alcoholism
TDLo:7500 mg/kg
(9D preg)
TFX:TER
LD50: 1440 mg/kg.
ivn-rat
USDS air: TWA TDLo:340 gm/kg/
1000 ppm or 57WI,TFX:CAR,
1900mg/m3 orl-mus
TDLo:100 gm/kg/
18WI,TFX:CAR,
rec-mus
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
154
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Dehydrochlorina-
tion
(Dichlorohydrin,
calcium or sodium
hydroxide, trichloro-
propane solvent)
291 Air: chlorine (1.0 g/
Mg),HCI (1.0kg/Mg),
ally) chloride (4 kg/
Mg), epichlorohydrin
(1.5 kg/Mg), trichloro-
propane (0.5 kg/Mg),
HCI (0.5 kg/Mg)
Emission factors:
Ally! chloride-4.0
Tail gas 229/1973 Synthesis; about 32% 1)692
absorber 225/1974 glycerine, about 12% 2)744
epoxy & phenoxy resins; 3)641
synthesis epichlorohydrin 5)561
elastomers; solvent for 7)10-17
cellulose esters & ethers; 12)
high wet-strength resins 13)35
for paper industry; starch
modifier
— See butane
Commercial fuel; refri- 3)721
gerant; chemical 7)8-385
manufacturing
Hydration
(Ethylene, water,
phosphoric acid
ondiatomite)
119 Water: (15-30) kg/COD/
Mg
Air: 1.1 kg/Mg ethanol,
trace acetaldehyde, ether
& ethylene
Emission factors:
1.1 kg/Mg ethanol, trace
acetaldehyde, ether &
ethylene
890/1973 Solvent for resins, fats, 1)312
862.6/1974 oils, fatty acids, hydro- 2)414
carbons, alkali hydroxides; 3)649
extractive medium, manu- 5)561
facture of intermediates, 6)623
organic derivatives 8)162
(especially acetaldehyde), 12)
dyes, synthetic drugs,
elastomers, detergents,
cleaning solutions, sur-
face coatings, cosmetics,
Pharmaceuticals, explosives,
anti-freeze; beverages; anti-
septics, medicines
See acetic acid
227
Emission factors:
ethylene oxide -
10.0
Ditto
Ditto
1)560
(Continued)
155
-------
TABLE A-2. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD, mg/kg
Toxicology
TLV
Carcinogen
188 Ethanolamine
DP (Ethanol, 2 amino)
(Monoethanol amine)
NH2CH2CH2OH
(C2H7NO)
000141435 2100 rat
(Z2Q)
Large doses can
cause alcohol
poisoning; CNS
depressant
LD50:981 mg/kg,
ipr-rat
LD50:2537 mg/kg,
scu-mus
LD50:1000 mg/kg,
skn-rbt
USOS air: TWA
3 ppm or 6
mg/m3
189
Ethyl acetate
(Acetic acid,
ethyl ester)
CH3COOC2H5
(C4H802)
000141786
(20V1)
1100rat-rbt
4935 rbt
LDLo:500
hmn
TCLo:400 ppm
TFX:IRR,ihl-hmn
Irr to muc surfaces,
eyes, gums &
respiratory tract;
mild narcotic
LC50:1600 ppm,
ihl-rat
LD50:5000 mg/kg,
scu-rat
LCLo:31 mg/m3/
60 M, ihl-mus
LD50:709 mg/kg,
ipr-mus
LD50:3000 mg/kg,
scu-cat
USOS air: TWA
400 ppm or
1400 mg/m3
Ditto
Ditto
Ditto
Ditto
Ditto
190 Ethyl acetonacetate
(Acetoacetic acid,
ethyl ester)
CH3COCH2COOC2H5
(C6H1003)
000141979
(20V1V1)
3980 rat
191
Ethyl acrylate
(Acrylic ackl,
ethyl ester)
CH2CHCOOC2H5
(C5H802)
000140885
(20V1U1)
1020 rat TCLo:50 ppm
400 rbt TFX:IRR, ihl-hmn
Oral administration
can result in death;
severe local irritation
of the GI tract; toxic
degenerative changes
of cardiac, hepatic,
renal, & splenic
tissues; no evidence of
cumulative effects
USOS air: TWA
25 ppm (skn) or
100 mg/m3
156
-------
Process
(Sources
of Compound)
Process
No. Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses References
See diethanol-
amine
152 Air: NH 3, traces of
ethanolamines
Fractionating Mono-di- 37% detergents; 22% gas 1)386
column, and tri- conditioning & petroleum 2)400
stripper ethanol use; 5% synthetic mor- 3)839
amines pholine; 20% exports; 5)561
141/1973 16% miscellaneous in- 12)
139/1974 eluding polishes & 13)35
165/1978 herbicides
See acetic acid
227
Emission factors:
ethanol - 5.0,
ethyl acetate - 5.0
100/1973 70% solvent in coatings; 1)560
89/1974 10% solvent in plastics; 2)26
103/1978 17% solvent in lacquers, 3)648
thinners & dyes; organic 12)
synthesis, Pharmaceuticals, 13)35
smokeless powders
Esterification
(Ethanol, acetic
acid, sulfuric
acid)
103 Water: sulfuric acid
Ditto
1)279
6)623
7)8-378
Clarsen reaction
(Ethyl acetate,
sodium, sulfuric
acid)
107 Water: organic & in-
organic sodium salts,
ethyl acetate, ethyl
acetoccetate
Organic synthesis, anti-
pyrine; lacquers; dopes;
plastics; manufacture of
dyes, Pharmaceuticals,
antimalarials, vitamin B;
flavoring
1)288
2)35
3)649
Esterification
(Acrylic acid,
ethanol, sulfuric
acid or Dowex 50
ion exchange
resin or silica gel
catalyst)
122 Water: kg/Mg
polymers (11.9),
hydroquinone (13.75)
Air: kg/Mg
ethanol (2.65).
ethylacrylate (1.6),
ethyl-acetate (5.25),
sodium carbonate
(0.26)
125.1/1973 Manufacturing: about 34% 1)321
139.6/1974 emulsion polymers (about 2)44
half used in surface coat- 3)649
ings), about 10% used in 6)604
other polymers (especially 11)37
solvent coatings & fibers); 13)36
organic synthesis;
miscellaneous
(Continued)
157
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
191 (Continued)
LCLo:1000ppm/4H,
ihl-rat
LCLo:1204ppm/7H,
ihl-rbt and gpg
LD50:1950 mg/kg,
skn-rbt
192
DP
Ethylamine
(Ethanamine)
C2H5NH2
(C2H7N)
000075047
(Z2)
400 rat High toxicity via
skn.orl.eye, &
mucous membrane
routes
LCLo:3000ppm/4H,
ihl-rat
LD50:390 mg/kg,
skn-rbt
USDS air: TWA
10 ppm or 18
193
Ethylbenzene
(Benzene, ethyl)
000100414
(2R)
(C8H10)
3500 rat TCLo: 100 ppm/4H,
ihl-hmn
Irr to skn & muc
men; in gpg, ex-
posure causes ataxia,
unconsciousness,
tremor & death
through respiratory
failure; effects of
chronic exposure
are unknown
LDLo:4000ppm/4H,
ihl-rat
LCLo: 10,000 ppm,
ihl-gpg
USDS air: TWA
100 ppm or
435 mg/m3
Ditto
Ditto
Ditto
Ditto
Ditto
194
Ethyl bromide
(Ethane, bromo-l
CH3CH2Br
(C2H5Br)
000074964
(E2)
Anesthetic &
narcotic; liver &
kidney damage
in hmn
LCLo:3200ppm,
ihl-gpg
LCLo:149000/
15M, ihl-rat
USDS air: TWA
200 ppm or 890
195
Ethylcellulose
(Cellulose, ethyl
ether)
009004573
(C8H1505)
Unknown
158
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
See Diethylamine 120
Emission factors:
ethyl chloride - 1.0,
NH3- 1.0
25.2/1972 Dye intermediate, solvent 1)316
extraction; petroleum re- 2)385
fining; stabilizer for 3)650
rubber latex; detergents; 4)431
organic synthesis; 5)561
plasticizers; deflocculants; 7)2-122
textile finishes 12)
Alkylation, liquid
phase or vapor
phase
(Benzene, ethylene,
aluminum chloride
or various solid
catalysts)
Liquid Phase Process
Water: kg/Mg
benzene (11),
HCI (3.9), alumi-
num salts (trace),
tars (26.6)
Vapor Phase Process
Water:
Flow (3.15m3/kg)
COD (5,980 mg/l)
(1.88g/kg)
BOD5 (433 mg/l)
(0.136g/kg)
TOC (2,091 mg/l)
(0.66 g/kg)
2580/1973 95.5% intermediate in 1)45
2750/1974 production of styrene; 2% 2)161
2145/1975 solvent; export 3)651
3809/1978 5)561
11)36
Heavy aroma-
tics disposed
of by
incineration
See Xylenes
359
1)826
Hydrobromination,
Bromination
(Ethylene, hydro-
gen bromide,
gamma irradiation
catalyst. Also
ethanol and HBr)
83
Organic synthesis; medi- 1 )234
cine (anesthetic); refri- 2)387
gerant; solvent; grain & 3)651
fruit fumigant 5)561
Alkylation
(Cellulose, 50%
NaOH soln, ethyl
chloride, HCI,
benzene or toluene)
118 Air: ethyl chloride,
ethanol, ethyl ether,
benzene or toluene
Water: NaOH, ethyl
cellulose, NaCI, de-
graded cellulose, all of
above under air
2.9/1973 Protective surface coat-
ings; hot-melt adhesives
& coatings for cables,
paper, textiles, etc.;
extrusion wire insulation;
pigment-grinding base;
toughening agent for
1)309
3)653
7)4-641
(Continued)
159
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgQ, mg/kg Toxicology
TLV Carcinogen
195 (Continued)
196
DP
Ethyl chloride
(Ethane, chloro-)
CH3CH2CI
C2H5CI
000075003
(G2)
TCLo:13,000 ppm,
TFX:CNS, ihl-hmn
Irr to eyes; causes
unconsciousness;
least toxic of all
chlorinated
hydrocarbons
LCLo:4000 ppm/
45M, ihl-gpg
USOS air: TWA
1,000 ppm or
2,600 mg/m3
197 Ethyl chloroacetate
(Acetic acid, chloro-,
ethyl ester)
000105395
(G1V01)
Moderate irr via
orl and ihl
198 Ethyl cyanoacetate
DP (Acetic acid, cyano-,
ethyl ester)
000105566
(NC1VO2)
Highly toxic
LC50:750 mg/kg,
ipr-mus
LDLo:1500 mg/kg,
scu-rbt
199 Ethylene
(C2H4)
000074851
(1U1)
Anesthesia; simple
asphyxiant;
phytotoxic
LC50:95 pph
ihl-mus
Lethal cone in
air for mice,
950,000 ppm
200 Ethylene carbonate
(Carbonic acid, cyclic
ethylene ester)
OCH2CH2OCO
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
plastics; printing inks;
molding powders; proxi-
mity fuses; vitamin pre-
paration; casing for
rocket propellants; food
& feed additive
Hydrochlorina-
tion, Chlorination
(Ethylene,
hydrogen chloride,
aluminum chloride
catalyst)
115 Water & air: ethylene,
HCI, ethyl chloride,
CH4, AlCIs
Emission factors:
ethylene dichloride -
12.0, ethyl chloride -
5.0, methane - 5.0,
ethane - 5.0, ethylene •
5.0
300/1973 80% manufacture tetra- 1)303
246/1978 ethyl lead; ethylcellulose; 2)387
anesthetic; organic syn- 3)654
thesis, alkylating agent; 7)5-146
refrigeration; analytical 9)205
reagent; solvent for 12)
phosphorus, sulfur, fats, 13)36
oils, resins & waxes;
insecticides; aerosols
Esterification
(Chloroacetic acid,
ethanol, sulfuric
acid catalyst)
110 Water: sulfuric acid,
ethyl chloroacetate,
chloroacetic acid,
ethanol
Solvent; organic synthesis; 1 )294
military poison gas; vat 2)17
dyestuffs 3)731
Substitution
(Ethyl chloro-
acetate, sodium
cyanide, ethyl
alcohol, sulfuric
acid)
113 Air: HCN
Water: Salts, dilute
acids, traces ethanol
and ethyl
syanoacetate
Organic synthesis, pharma- 1)299
ceuticals; dyes 2)19
3)655
10,859/1974 Manufacturing: 40% poly- 2)418
12,786/1978 ethylene,20% ethylene 3)657
oxide, 14% ethylene di- 4)434
chloride & deriv., 8% 6)626A
ethyl benzene, 6% 7)C-519
ethanol, 12% misc. 13)36
including: ethylene glycols,
aluminum alkyls, ethyl
chloride, ethylene chloro-
hydrin, acetaldehyde,
linear alcohols, trichloro-
ethylene, etc.
Condensation,
Addition
(Ethylene oxide.
CO2, catalyst)
1 56 Water: Traces of —
reactants and
products pi us CO
— Solvent for many
polymers & resins; sol-
vent extraction; syn-
thesis of Pharmaceuti-
cals; rubber chemical.
textile finishing agents
1)394
2)283
3)657
(Continued)
161
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD5Q, mg/kg
Toxicology
TLV Carcinogen
201 Ethylene chloro-
hydrin
(Ethanol, 2-chloro-)
CH2CICH2OH
(C2H5CIO)
000107073
(Q2G)
LDLo:50 hmn
4)434
58 rat
2)402
81 mus
110 gpg
LCLo:300ppm/2H,
ihl-hmn
LDLo:5000 mg/kg,
TFX:SKN,skn-hmn
Highly toxic
LCLo:32 ppm/4H,
ihl-rat
LDLo:72 mg/kg,
ipr-rat
LD50:84 mg/kg,
skn-rat
LD50:385 mg/m3,
ihl-mus
USOS air: TWA
5 ppm (skn) or
16 mg/m3
202 Ethylene diamine
(1,2-ethanediamine)
000107153
(Z2Z)
(C2H8N)
1160 rat TCLo:200ppm,
4)434 TFXMRR, ihl-hmn
760 rat Air dermatitis
470 gpg asthma
LC50:4000 ppm/8H,
ihl-rat
LD50:424 mg/kg,
scu-mus
LD50:730 mg/kg,
skn-rbt
USOS air: TWA
10 ppm or 25
mg/m3
203 Ethylene dibromide
DP (Ethane, 1,2-dibrbmo)
CH2BrCH2Br
000106934
(E2E)
140 rat
55rbt
110 gpg
79ckn
LDLo:250
mus
LDLo:50 mg/kg,
orl-hmn
LDLo:80 mg/kg,
orl-hmn
High toxicity via
skn.orl or ihl
LCLo:400ppm/2H,
ihl-rat
LD50:300 mg/kg,
skn-rbt
LCLo:400 ppm/3H,
ihl-gpg
USOS air: TWA
20 ppm or 145
mg/m3
CL 30 ppm
PK 50 ppm/5M/
8H
TDLo: 400 mg/kg/
10WI
TFX:CAR,orl-rat
TDLo:18gm/kg/
42 WI
TFX:CAR,orl-mus
162
-------
Process
(Sources Process
of Compound) No.
Addition 136
(Ethylene, chlorine,
aqueous sodium
hydroxide)
Waste
Associated Wastes Treatment
Water: hypochlorous —
acid, chlorine, NaOH,
HCI, NaCI, ethylene
chlorohydrin, possibly
ethylene dichloride
and dichloroethyl
ether (known
carcinogen)
Total
Production
106 kg/year Uses
— Solvent for cellulose
acetate, ethylcellulose;
introduction of hydro-
ethyl group in organic
synthesis; to activate
sprouting of dormant
potatoes; manufacture
of ethylene oxide &
ethylene glycol; dyes
References
1)357
2)402
3)657
4)434
5)561
7)5-309
Amination,
Ammonolysis
(Ethylene dichlo-
ride, ammonia,
sodium
hydroxide)
134 Air: ammonia, ethyl-
enediamine, higher
amines, ethylene
dichloride
Water: sodium
hydroxide, ammonium
chloride
Emission factors:
ethylene dichloride -
1.0, hydrocarbons-
1.0, NH3- 1.0
30/1974 Manufacturing: 25% 1)353
carbamate fungicides, 2)387
13% chelating agent 3)658
(EDTA),8%dimethlol- 4)434
ethylene urea resins, 8% 5)561
aminoethylethanolamine, 10)
25% exports, 21% misc.; 12)
solvent for albumin & 13)36
fibrin; medicine; neutrali-
zing oils; stabilizing rubber
latex; corrosion inhibitor
in antifreeze solutions;
textile lubricants; dyes;
rubber accelerators; making
ethylenediamine nitrate,
chlorate; dehairing skins;
polyamide resin adhesives
Bromi nation
(Ethylene,
bromine)
114
Emission factors:
ethylene bromide -
10.0, ethylene -
5.0, Br2- 1.0
150.3/1973 Almost 100% used as 1)301
scavenger for lead in 2)388
gasoline; grain & fruit 3)658
fumigant; general solvent; 5)563
waterproofing prepara- 6)627
tions; organic synthesis; 9)205
insecticides; medicine 12)
13)
(Continued)
163
-------
TABLE A-1. (Continued)
Item
No.
204
Compound
Name and
Formula
Ethylene dichloride
(Ethane, 1,2-dichloro)
EDC
CH2CICH2CI
C2H4CI2
Chem. Abstr.
Registry No.
(WLN)
000107062
(G2G)
Oral Toxicity,
LD5Q, mg/kg
680 rat
2)388
770 rat
3)658
Toxicology
LDLo: 500 mg/kg.
orl-hmn
LDLo:810 mg/kg.
orl-man
TDLo:428 mg/kg.
TFX:G IT, orl-hmn
TLV
USDS air: TWA
50 ppm or 200
mg/m3
CL 100 ppm
PK 200 ppm/5M/
8H
Carcinogen
Experimental
carcinogen 3)658
TCLo:4000 ppm/H,
TFX:CNS, ihl-hmn
Irr to eyes &
upper respiratory
tract. Narcotic.
Fatty degeneration
of liver & kidneys
in aminal experi-
ments. Dermatitis
& edema in the
lungs.
Experimental
mutagen & teratogen
3)658
LCLo:1000ppm/4H,
ihl-rat
LDLo:600 mg/kg,
ipr-rat
LDLo:500 mg/kg,
scu-rat
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
164
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses References
Oxychlorination 132 Air: 43 Gg/yr hydro- Water:
(Ethylene, HCI, carbon emission for Direct fired
02, CuCl2 Oxychlorination boiler plus
catalyst) process. scrubber con-
Specific compounds trol system
in kg/hr: CC>2 (957), thermal incinera-
CO (264), CH4 (78), tor and scrubber
ethylene (191), system
ethane (260), ethylene
dichloride (272), ethyl
chloride (231), aromatic
solvent (43)
Water: Total 0.1908
Gg/Gg EDC. Scrubber
effluent 142 Mg/hr
Solids: 181 Mg/yr
4210/1973 Synthesis: 81% vinyl 1)343
3496/1974 chloride, 3% methylchloro-2)388
2700/1975 form, 3% trichloroethy- 3)658
4755/1978 lene, 3% ethyleneimines, 5)563
3% perchloroethylene; 6)627
2% vinylidene chloride; 7)5-153
3% coupling agent in 9)205
antiknock gasoline; paint 10)
varnish & finish remover; 11)33
metal degreasing; soaps
& scouring compounds
Chlorination
(Ethylene,
chlorine, FeCl3
catalyst)
131 Air: 13.1 Gg/yr
hydrocarbon emission
for chlorination pro-
cess. Specific com-
pounds kg/Mg:
ethane (3.0), ethylene
(7.5), CH4 (3.0), CI2
(0.5), HCI (0.5)
Water: kg/Mg
C>2 (0.874), ethylene
dichloride (3.25),
HCI (3.8), vinyl
chloride (0.6), 1,1,2-
trichloroethane (2.45),
tetrachloroethane
(2.45), methyl chlo-
ride (0.05), ethyl
chloride (0.05), NaOH
(0.6), NaCI (0.2), tars
(trace)
Water: HCI
scrubber and
solids fitter
Ditto
Ditto
1)339
"Balanced
Process"
(Ethylene, Cl2,
HCI,02>
131
&
132
See 131 and 132
Ditto
Ditto
Ditto
1)343
1)339
(Continued)
165
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
205
DP
Ethylene glycol
CH2OHCH2OH
(C2H602)
000107211
(Q2Q)
5840 rat-cat
6610gpg
2000 cat
LDLo: 1500 mg/kg,
orl-hmn
Lethal dose for man
is 100 ml. CNS
stimulation followed
by depression. Kid-
ney damage causes
death. Very toxic
in paniculate form.
LD50:3000 mg/kg,
ivn-mus
LDLo:2700 mg/kg,
scu-mus
LDLo: 1000 mg/kg,
ipr-rbt
100ppm;260
mg/m3
TDLo:4gm/kg
TFX:NEO, skn-mus
3)659
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
206
Ethylene glycol
diacetate
(CH2OOCCH3)2
(C6H1004)
000111557
(1V020V1)
6850 rat
4940 gpg
LDLo:500 mg/kg,
orl-hmn
LD50: 1070 mg/kg,
ipr-mus
LD50:8480 mg/kg,
skn-rbt
207 Ethylene glycol
dibutyl ether
(Ethane, 1,2-dibutoxy)
Dibutyl Cellosolve
(C4Hg)2OCH2CH2O
(C10H2202)
000112481 3250 rat
(40204)
208 Ethylene glycol
diethyl ether
(Ethane, 1,2-diethoxy-)
Diethyl Cellosolve
000629141 4390 rat
(201V102)
2440 gpg
LCLo:8000 ppm/4H
ihl-rat
166
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses References
Condensation &
Reduction, Car-
bonylation &
reduction
(Formaldehyde,
CO, BF3 catalyst,
then H2 and
CuO/MgO
catalyst)
203 Water: formaldehyde,
methanol, alcohols,
acids
1489/1973 50% coolant & anti- 1)504
1518/1974 freeze; manufacturing; 2)421
1727/1975 35% polyester fiber, 4% 3)659
1827/1978 alkyd & polyester resins, 6)627
1% emulsion paints; 8)164
asphalt-emulsion paints; 9)203
heat-transfer agent in re- 11 )36
f rigeration & electron
tubes; low-pressure lami-
nates; brake fluids; glycol
diacetate; low-freezing
dynamite; solvent;
extractant for various pur-
poses; solvent mixtures
for cellulose esters &
ethers, especially cello-
phane; cosmetics (up to
5%); lacquers; printing
inks; wood stains;
adhesives; leather dyeing;
textile processing; tobacco;
ingredient of deicing fluid
for airport runways
See diethylene
glycol
144
Ditto
Ditto
1)374
Esterification
(Ethylene glycol,
acetic acid)
145 Air & Water: ethylene
glycol, acetic acid,
ethylene glycol,
mono- & diacetate
2.8/1973 Solvent for cellulose 1)377
esters & ethers; resins; 2)431
lacquers; printing inks; 3)660
perfume fixative; non- 9)203
discoloring plasticizer
for ethyl & benzyl
cellulose
See diethylene
glycol monobutyl
ether acetate
150
High-boiling inert solvent; 1 )384
specialized solvent & 2)388
extraction applications
Ditto
150
Organic synthesis
(reaction medium); sol-
vent & diluent for
detergents
1)384
2)389
(Continued)
167
-------
TABLE A-1. (Continued)
Compound Chern. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgQ, mg/kg
Toxicology
TLV
Carcinogen
209
Ethylene glycol
dimethyl ether
(Ethane, 1,2-
dimethoxy)
(CH3OCH2)2
(C4H1002)
(10201)
Unknown
210 Ethylene glycol
monoacetate
CH3COOCH2CH2OH
(C4H803)
000542596
(Q20V1)
3800 gpg
Low toxicity in
animal experiments
LD50:1310 mg/kg,
ipr-mus
211 Ethylene glycol
monobutyl ether
(Ethanol, 2-butoxy-)
(Butyl Cellosolve)
C4HgOCH2CH2OH
(C6H1402)
000111762
(0204)
1480 rat
1230 mus
320 rbt
1200gpg
LDLo:50 mg/kg,
orl-hmn
TDLo:195 ppm/8H,
TFX:IRR, ihl-hmn
LCLo:500ppm/4H,
ihl-rat
LD50:550 mg/kg,
ipr-rat
LD50:340 mg/kg,
ivn-rat
LC50:700ppm/7H,
ihl-mus
LD50:536 mg/kg,
ipr-mus
LD50:1130mg/kg,
ivn-mus
LD50:280 mg/kg,
ivn-rbt
LD50:230 mg/kg,
skn-gpg
USDS air: TWA
50 ppm (skn)
or 240 mg/m3
212 Ethylene glycol
monobutyl ether
acetate
(Ethanol, 2-butoxy-,
acetate)
(Butyl Cellosolve
Acetate)
000112072
(4020V1)
3200 mus
LDLo:1600
rat
LD50:1580 mg/kg,
skn-rat
213 Ethylene glycol
monoethyl ether
(Ethanol, 2-ethoxy)
(Cellosolve)
C2H5OCH2CH2OH
000110805
(Q202)
3000 rat
4300 mus
3100 rbt
1400 gpg
LDLo:500 mg/kg,
orl-hmn
Saturated (0.6%)
vapor in air for
18-24 hours may
produce congestion
& edema of lungs
& congestion of
kidneys in animals.
Irr to eyes in hmn.
USDS air: TWA
200 ppm (skn)
168
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
See diethylene
glycol monobutyl
ether acetate
150
Solvent
1)384
3)660
See ethylene
glycol diacetate
145
Solvent for nitrocellulose, 1)377
cellulose acetate, 2)421
camphor 3)660
See diethylene
glycol monobutyl
ether
149 Emission factors:
ethylene oxide - 1.0,
butanol - 0.5
62.4/1973 Solvent for nitrocellulose
resins; spray lacquers;
varnishes; enamels; dry-
cleaning compounds;
varnish removers; textile
(preventing spotting in
printing or dyeing);
mutual solvent for
"soluble" mineral oils to
hold soap in solution &
to improve the emulsifying
properties; synthetic 2-
butoxyethyl acetate, di(2-
butoxyethyDphthalate
1)381
2)401
3)659
5)560
9)204
12)
13)37
See diethylene
glycol monobutyl
ether acetate
151
High-boiling solvent for 1)385
nitrocellulose lacquer, 2)401
epoxy resins, multicolor 3)439
lacquers; film coalescing
aid for polyvinyl acetate
latex
See diethylene
glycol monobutyl
ether
149 Emission factors:
ethylene oxide - 1.0
72.2/1974 Synthesis: 2-ethoxyethyl 1)381
86.5/1973 acetate solvent; nitro- 2)405
cellulose, natural & 3)475
synthetic resins; mutual 6)636
solvent for formulation 9)204
of soluble oils; lacquers 10)
& lacquer thinners; 12)
dyeing & printing textiles;
varnish removers; cleaning
solutions; leather;
(Continued)
169
-------
TABLE A-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
213 (Continued)
Absorbed by skn
LCLo:4000 ppm/4H,
ihl-rat
LCLo:1820ppm,
ihl-mus
LD50:1710 mg/kg,
ipr-mus
214 Ethylene glycol
monoethyl ether
acetate
(Ethanol, 2-ethoxy-,
acetate)
(Cellosolve Acetate)
(C6H1203)
000111159
(2020V1)
5100 rat Absorbed by skn USDS air: TWA
1910gpg LCLo:1500ppm/4H, 100ppm(skn)
ihl-rat or 540 mg/m3
LD50:1420 mg/kg, *
ipr-mus
215 Ethylene glycol
monohexyl ether
(Ethanol, 2(hexyloxy))
(Hexyl Cellosolve)
C6H13OCH2CH20H
(C8H1802)
000112254 1480 rat
(Q206)
LD50:890 mg/kg,
skn-rbt
216 Ethylene glycol
monomethyl ether
(Ethanol, 2-methoxy)
(Methyl Cellosolve)
CH3OCH2CH2OH
(C3H802)
000109864
(Q201)
2460 rat LDLo:3570 mg/kg,
890 rbt orl-hmn
950 gpg TCLo:25 ppm,
TFX:CNS, ihl-hmn
Abnormalities in
blood, exaggerated
reflexes, tremors
LDLo:2000ppm/4H,
ihl-rat
LD50:2140 mg/kg,
ivn-rat
LC50:1340 mg/kg,
ihl-rbt
LD50:1340 mg/kg,
skn-rbt
USDS air: TWA
25 ppm (skn) or
80 mg/m3
217 Ethylene glycol
monomethyl ether
acetate
(Ethanol, 2-methoxy-
acetate)
(Methyl Cellosolve
Acetate)
CH3OCH2CH2OOCCH3
(C5H1003)
000110496
(1V0201)
3390 rat LDLo:500 mg/kg, USOS air: TWA
1250 gpg orl-hmn 25 ppm (skn) or
TCLo: 1000 mg/m3 120 mg/m3
TFX:IRR, ihl-hmn
LCLo:7000ppm/4H,
ihl-rat
170
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
anti-icing additive for
aviation fuels
Ditto
151 Emission factors:
ethoxyethanol - 1.0
Solvent for nitrocellulose; 1)385
oils & resins; retards 2)405
"blushing" in lacquers, 3)475
varnish removers; wood 5)561
stains; textiles; leather 12)
See Diethylene
glycol monobutyl
ether
149
High-boiling solvent
1)381
2)406
3)724
Ditto
Ditto
Emission factors:
2-methoxyethanol •
1.0, ethylene - 1.0
39.1/1973 51% jet fuel deicing addi- 1)381
live; 10% solvent for 2)407
nitrocellulose, cellulose 3)661
acetate, natural & syn- 5)561
thetic resins, alcohol- 6)636
soluble dyes, varnishes; 9)204
leather; perfume fixative; 12)
wood stains; sealing 13)37
moisture-proof cellophane
151
Solvent for nitrocellulose, 11385
cellulose acetate, various 2)407
gums, resins, waxes, oils; 3)813
textile printing; photo 5)561
film; lacquers; dopes
(Continued)
171
-------
TABLE A-1. (Continued)
Item
No.
218
Compound
Name and
Formula
Ethylene glycol
monooctyl ether
(Ethanol, 2-octyloxy-)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg Toxicology
010020436 — Unknown
(Q208)
TLV Carcinogen
.
20
000075218
(T30TJ)
330 rat Irr to eyes & muc
270 gpg mem of respiratory
-act; high cone can
cau-? pulmonary
edema
TCLo:1000ppm/4H
TFX:MUT
TDLo:30mg/m3
TFX:MUT, ihl-man
LC50:1462 ppm/4H,
ihl-rat
LC50:836 ppm/4H,
ihl-mus
LC50:960 ppm/4H,
ihl-dog
LCLo:7000ppm/
150M, ihl-gpg
222 Ethyl ether
(Ethane, 1,1'-oxybis)
C2H5OC2H5
000060297
(202)
1700 rat LDLo:420 mg/kg,
orl-hmn
TCLo:200 ppm
TFX:IRR, ihl-hmn
CNS depressant;
death results
from severe &
continued exposure
LDLo:2000 mg/kg,
ipr-gpg
LCLo: 76,000 ppm,
ihl-dog
USDS air: TWA
400 ppm or
1200 mg/m3
172
-------
Process
(Sources
of Compound)
See diethylene
glycol rnonobutyl
ether
Process
No. Associated Wastes
149
Total
Waste Production
Treatment 10^ kg/year Uses
— — Solvent for cellulose
esters; plasticizer
References
1)381
3)661
Ditto
Ditto
Solvent for cellulose
acetate, dyes, inks, re-
sins; perfume & soap
fixative; bacterial agent;
organic synthesis of
plasticizers, germicides,
perfume materials &
Pharmaceuticals
1)381
2)408
3)900
Ditto
Ditto
1)381
2)409
Oxidation 143 Air: ethylene. Gas scrubber, 1890/1973 Synthesis: ethylene glycol 1)370
(Ethylene, ethylene oxide stripper 1765/1974 27% antifreeze; 23% poly- 2)422
oxygen, air) Water: flow from 2195/1978 ester fiber & film; 13% 3)662
2 plants given surfactants; 10% misc.; 6)628
inD 9% ethanolamines; pet- 7)8-552
roleum demulsif ier; 11)37
fumigant; rocket pro-
pellant; sterilizers;
insecticides
See ethanol
process no. 119
(Ethylene, water,
phosphoric acid
catalyst)
119
Emission factors:
ethanol - 3.0,
ethylene - 3.5
32.8/1973 65% industrial solvent
27.2/1974 (smokeless powder); 25%
synthesis; 3% anesthetic;
perfumery; extractant;
alcohol denaturant
1)312
2)390
3)663
5)561
6)630
7)8-486
9)205
10)
12)
13)38
(Continued)
173
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
223 2-Ethylhexanol 000104767
(1-Hexanol,-2-ethyl) (Q1Y4&2)
C4H9CH(C2H5)CH20H
(C8H180)
3200 rat
LDLo:3200
LD50:2380 mg/kg,
skn-rbt
224 Ethylorthoformate
DP (Orthoformic acid,
triethyl ester)
000122510
(20 3Y)
2920 rat Irrtoskn&muc
mem. Narcotic in
high concn.
LCLo:8000 ppm/4H,
ihl-rat
225 Ethyl oxalate
DP (Oxalic acid, diethyl
ester)
(COOC2H5)2
(C6H1004)
000095921
(20VV02)
400 rat
Orl toxicity high
226
DP
Ethyl sodium
oxalacetate
(Oxalacetic acid,
diethyl ester)
ONA
026103775
(20VV1VO
& -NA-)
227
DP
Formaldehyde
(HCHO)
000050000 800 rat
(VHH)
260 gpg
LDLo: 36 mg/kg,
orl-wmn
LDLo:500 mg/kg,
or-hmn
TCLo:17 mg/m3/
30M,TFX:IRR,
ihl-hmn
Irr; violent vomit-
ing & diarrhea
leading to collapse
USOSairTWA TDLo:1300mg/
3ppm;CL5 kg/65WI, TFX:
ppm;PK10 NEO,scu-rat
ppm/30M/8H
174
-------
Process
(Sources Process
of Compound) No.
(Ethanol, sulfuric 127
acid)
Condensation & 90
hydrogenation
(n-Butyraldehyde,
hydrogen, Ni,
catalyst)
Substitution, 167
Addition
(Hydrogen cyanide.
ethanol, hydro-
chloric acid)
Esterification 121
(Oxalic acid.
ethanol)
Total
Waste Production
Associated Wastes Treatment 10^ kg/year
— — Ditto
Air: butyraldehyde Heavy ends 183/1973
(58.5 kg/mg) light usually burned 224/1977
hydrocarbons (113.5 189/1978
kg/Mg) 2-ethylhexanol
Emission factors:
hydrocarbons- 227.0,
butyraldehyde -
117.0
Air or water: chlorine, — —
chlorohydrocarbons
Water: solvent, ethanol, —
oxalic acid, ethyl
oxalate
Uses References
Ditto
Manufacturing: 80% plasti-
zer, mostly for PVC re-
sins, 10% 2-ethyl hexyl-
acrylate defoaming agent;
wetting agent; organic
synthesis; solvent mix-
tures for nitrocellulose.
paints, lacquers, baking
finishes; penetrant for mer-
cerizing cotton; textile
finishing compounds;
plasticizers; inks; rubber;
paper; lubricants; photo;
dry cleaning
Intermediate; general pur-
pose food additive
Solvent for cellulose &
ethers, many natural &
synthetic resins; radio
1)332
1)249
2)458
9)203
12)
13)38
1)427
2)605
3)1052
1)319
2)609
3)671
Air: ethanol & solvent
tube cathode fixing
lacquers; dye inter-
mediate; Pharmaceuticals;
perfume preparation;
organic synthesis
Claisen reaction
(Ethylacetate,
ethyl oxalate,
sodium alcoholate)
129
Dyes, synthesis
1)335
Oxidation
(Methanol, air,
silver catalyst)
202 Air: CO (63.5 g/kg
37% formaldehyde),
H2 (7.6 g/kg), CH4
(1.25 g/kg), HCHO
(trace), CH3OH
trace)
Water: dimethyl
ether
(37 wt per- Manufacturing: 30% urea 1)500
cent) & melamine resins, 24% 2)428
2918/1973 phenolic resins, 9% 3)694
2654/1974 acetal resins, 6% penta- 6)632
2923)1978 erythritol, 6% hexa- 11)36
methylenetetramine, 4% 13)38
melamine-resins, 3%
tetrahydrofuran, 3%
acetylenic chemicals,
2% -4,4'-methylenedianiline,
/Continued)
175
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
227 (Continued
DP
LCLo:250ppm/4H,
ihl-rat
LD50:420 mg/kg,
scu-rat
LCLo:900 mg/m3/
2H, ihl-mus
LDLo: 16 mg/kg,
ipr-mus
LD50:300 mg/kg,
scu-mus
LDLo:550 mg/kg,
scu-dog
LCLo:820mg/m3/
8H, ihl-cat
LDLo:240 mg/kg,
scu-rbt
228
DP
Formamide
HCONH
(CH3NO)
000075127
(ZVH)
7500 rat
TDLo:6gm/kg (7-
i20preg)
TFX:TER,orl-rat
TDLo:6gm/kg/
(11-16Dpreg),
TFX:TER, ipr-rat
USDS air: TWA
20ppm
229
DP
Formic acid
HCOOH
(CH2O2)
000064186
(VHQ)
1210 rat
1100 mus
4000 dog
Irr to skn, eye, &
macous membranes
LD50:940 mg/kg,
ipr-mus
LD50:145 mg/kg,
ivn-mus
LDLo:239 mg/kg,
ivn-rbt
USDS air: TWA
5 ppm or 9
mg/m3
Ditto
Ditto
Ditto
Ditto
Ditto
176
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
2% trimethylolpropane,
1% acrylic esters, misc.,
including 3% chelating
agents & 2% textile
applications; dyes; medicine
(disinfectant, fungicide,
germicide); embalming
fluids; preservative;
hardening agent
Ammonolysis
(Methyl or
ethyl formate,
ammonia)
199
Air: methanol or
ethanol
Solvent, softener, interest 1)495
in organic synthesis; print- 2)428
ing ink; sodium silicate 3)694
silicate gelation 7)10-105
See butyric
acid
227
Emission factors:
CO - 15.0, formic
acid - 1.0
24.2/1973 Dyeing & finishing of
textiles & paper, leather
treatment; chemicals
(formates, oxalic acid,
organic esters); manu-
facturing of fumigants,
insecticides refrigerants;
solvent for perfumes,
lacquers; electroplating;
medicine; brewing (anti-
septic); silvering glass;
cellulose format; natural
latex coagulant; ore
flotation; vinyl resin
plasticizers; animal fee
additive; packaging
1)560
2)430
3)695
5)561
7)10-102
9)201
12)
Condensation
94
Air: acetaldehyde,
formaldehyde,
methanol, ethanol
Water: sodium
formate, inorganic
sodium salts
Ditto
1)257
(Continued)
177
-------
TABLE A-1. (Continued)
Item
No.
230
Compound
Name and
Formula
Fumaric acid
HOOCCHCHCOOH
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
000110178 LDLo:5000rbt
(QV1U1VQ-T)
Toxicology TLV
LD50:200 mg/kg, —
ipr-mus
Carcinogen
—
Ditto Ditto Ditto Ditto
231 Glyceraldehyde 000367475 LDLo:5000 rat
CHOCHOHCH2OH (VHYQ1Q)
(C3H603)
232 Glycerine 000056815 470 mus Ihl irr 10mg/m3
DP (Glycerol (Q1YQ1Q) 12600rat LD50:4250 mg/kg,
CH2OHCHOHCH2OH 7150 gpg ivn-mus
(C3H8O3) LD50:10,000 mg/kg,
scu-mus
Ditto Ditto Ditto Ditto Ditto
Ditto Ditto Ditto Ditto Ditto
178
-------
Process
(Sources Process
of Compound) No.
Oxidation 24
(Benzene, air,
VjOs + P2C>5
catalyst)
Isomerization 43
(Maleic acid, base.
acid, or salt
catalyst)
Epoxidation and 254
hyd ration.
Hydroxylation
(Acrolein, hydrogen
peroxide)
Epoxidation and 252
hyd ration
(Allylalcohol,
hydrogen peroxide.
sodium hydroxide,
tungstic acid)
Associated Wastes
Air or Water:
benzene
Emission factors:
benzene - 15.0,
malic acid - 4.0,
f umeric acid - 4.0,
NH3-3.0
Air: unreacted
hydrocarbons
Water: acrolein.
glycidaldehyde,
glyceraldehyde
Air: kg/Mg
Allyl alcohol (6),
butanol (2),
acrolein (20),
light impurities
(22)
Water: kg/Mg
allyl alcohol (4),
glycerin (3.5),
light impurities
(23.5)
Total
Waste Production
Treatment 10*5 kg/year Uses
24.3/1973 34% food acidulants, 26%
19.1/1974 synthetic resins (unsat-
urated polyesters), 14%
paper-size resins, 10%
surface coatings (alkyd
resins), 4% plasticizers;
resin esters & adducts;
upgrading natural drying
oils (especially tall oil)
to improve drying char-
acteristics; mordant;
organic synthesis
— Ditto Ditto
— — Biochemical research;
intermediates; nutrition;
preparation of polyesters,
adhesives; cellulose modi-
fier; leather tanning
— 94.4/1973 23% drug & cosmetics,
(Synethetic 21% manufacture arkyd
only) resins, 15% tobacco, 12%
161.8/1974 foods & beverages, 1 1 %
cellophane, 10% poly-
ester polyols, 5% ex-
plosives, misc.; solvent;
printer's ink rolls; poly-
urethane polyols; emulsi-
fying agent; inks; binder
References
1)95
2)432
3)697
9)202
10)
12)
13)38
1)135
1)622
2)442
1)618
3)442
6)633
9)203
10)
13)39
for cements & mixes; paper
coatings & finishes;
special soaps; lubricant
& softener; bacteriostat;
hydraulic fluid
Hydrogenation
(G lyceraldehyde,
hydrogen, Ni
catalyst)
255 Air: glyceraldehyde,
glycerol
Ditto
1)624
Epoxidation and
hydrolysis, peroxi-
dation and hydrolysis
(Allyl alcohol,
peracetic acid)
292 Air: Allyl alcohol, t-
butyl alcohol
Water: allyl alcohol,
glycidol sodium
carbonate, t-butyl
alcohol or methyl
phenyl carbinol
Ditto
1)693
(Continued)
179
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgo, mg/kg Toxicology TLV Carcinogen
232 (Continued)
Ditto Ditto Ditto Ditto Ditto —
Ditto Ditto Ditto Ditto Ditto
233 Glycerol tri-
(polyoxypropylene)
ether
(CHO)3
(C3H303)
234 Glycine 000056406 — Unknown
DP O (Z1VQ) LDLo:3000 mg/kg,,
NH2-CH2-COH ivn-cat
235 Glyoxal 000107222 760 gpg LD50:200 mg/kg,
OCHCHO (VHVH) 1105 rat ipr-mus
LDLo:100 mg/kg,
ipr-rat
180
-------
Process
(Sources
of Compound)
Process
No. Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses References
Hydration and sub-
stitution, hydration
and dehydrochlori-
nation
(Epichlorohydrin,
sodium hydroxide,
sodium carbonate,
toluene, HCI)
319
Water: glycerol (&
toluene amounts
given in 1))
Second effect
evaporator
Centrifuge
Film evaporator
Toluene recovery
column
Light ends
column
See item above
1)742
4)499
6)633
7)10-627
Addition and sub-
stitution, Chloro-
hydrination and
hydrolysis
(Allylalcohol,
chlorine, sodium
hydroxide)
318
Ditto
1)740
Polyether forma-
formation
(Glycerol, pro-
pylene oxide,
ethylene oxide)
293
Air or water: pro-
pylene oxide,
glycerol, product,
propylene glycol
Mostly flexible poly- 1 )695
urethane foams, also rigid 13)39
foams, surfactants, lubri-
cants & functional fluids
Ammonolysis
(Chloroacetic
acid, ammonia)
108
Water: ammonia,
ammonia salts,
chloroacetic acid,
glycine
Organic synthesis, medi- 1)290
cine; biochemical re- 2)443
search; buffering agent; 3)707
chicken feed additive;
reduces bitter taste of
saccharin
Oxidation
(Acetaldehyde,
nitric acid)
91
Manufacture of textile 11251
resins for permanent press 2)445
process; dimensional 3)708
stabilization of rayon & 4)502
other fibers; insolubilizing
agent for compounds con-
taining polyhydroxyl
groups (polyvinyl alcohol,
starch, & cellulosic
materials); insolubilizing
or proteins (casein,
gelatin & animal glue);
embalming fluids; leather
tanning; paper coatings
with hydroxylethyl-
cellulose; reducing agent
in dyeing textiles
(Continued)
181
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD5Q, mg/kg
Toxicology
TLV Carcinogen
236
Guanidine
(N2N)2CNH
(CH5N3)
000113008
(ZYZUM)
LDLo:22.5 mg/kg,
ipr-rat
LDLo:266 mg/kg,
scu-mus
LDLo: 10 mg/kg,
ipr-cat
LDLo: 150 mg/kg,
scu-rat
LDLo:266 mg/kg,
scu-mus
237
Heptene
(C7H14)
000592767
(6U1)
Simple asphyxiant
238
Hexachloroethane
(Ethane,
hexachloro)
CCI3CCI3
000067721
(GXGGXGGG)
LDLo:50 mg/kg,
orl-hmn
LDLo:325 mg/kg,
ivn-dog
LDLo:4000 mg/kg,
scu-rbt
USDS air: TWA
1 ppm (skn) or
10mg/m3
239 Hexadecyl alcohol
(1-Hexadecanol)
(Cetyl alcohol)
CH3(CH2)14CH2OH
000124298
(Q16)
Practically nontoxic
LD50:2600 mg/kg,
skn-rbt
240 Hexamethylene glycol 000629118 3730 rat
(1,6-Hexanediol) (Q6Q)
(C6H1402)
Moderate orl toxicity
182
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
Ammonolysis
(Urea, ammonia,
sulfur dioxide)
185
Air: ammonia and
S02
Water: Traces of
reactants and
products
Solid: Sulfur
204/1967 Organic synthesis
1)465
2)446
Addition, Poly-
merization
(C3 refinery gas
(propylene),
04 refinery gas
(butylenes))
62 Air: olefins
Emission factors:
hydrocarbons - 2.0
Organic synthesis, plant 1)178
growth retardant; lubri- 3)715
cant additive; catalyst 12)
surfactants
Chlorination
(Perch loroethylene,
chlorine, sodium
hydroxide, ferric
chloride catalyst)
236 Water: NaCI, NaOH,
chlorinated hydro-
carbons, perchloro-
ethylene, hexachloro-
ethane
Organic synthesis; retard- 1)576
ing agent in fermentation; 2)390
camphor substitute in
nitrocellulose; rubber
accelerator; pyrotechnics
& smoke devices; solvent;
explosives; medicine; high
pressure lubricants; moth
repellant; pesticides
5)461
7)5-168
45.7/1973 Perfumery; emulsifier; 3)532
emollient; foam stabilizer 6)
in detergent; face creams;
lotions, lipsticks; toilet
preparations; chemical
intermediates; detergents;
pharmaceutical; cosmetics;
base for making sulfonated
fatty alcohols; to retard
evaporation of water, when
spread as a film on
reservoirs, or sprayed on
growing plants
Solvent; resin inter- 2)456
mediate coupling agent 3)722
(Continued)
183
-------
Item
No.
241
242
Compound
Name and
Formula
Hexamethylenetetra-
mine
(Urotropin)
(CH2)6N4
(C6H12N4)
Hexylene glycol
(2,4-PEntanediol,
2-methyl)
(2,4-amylene glycol)
Chem. Abstr.
Registry No.
(WLN)
000100970
(T66 B6 ABC
1B I&BN DN
FN HNTS)
000107415
(QY1XQ)
CH3COH(CH3)CH2CHOHCH3
243
DP
(C6H1402)
Hydrogen cyanide
(Hydrocyanic acid)
HCN
(CHN)
000074908
/Mpl_|\
\iML«n/
Oral Toxicity,
LD50' mg/k9
__
4000 rat
2)620
6860 rat
4)531
3860 mus
3200 rbt
2800 gpg
3.7 mus
LDLo:4,
dog
LDLo:2,
cat
Toxicology TLV Carcinogen
LDLo: 500 mg/kg, — TDLo:144gm/kg/
orl-hmn 72WI,TFX:NEO,
skn rash scu-rat
LDLo:512 mg/kg.
ipr-mus
LD50:9200 mg/kg.
ivn-rat
LD50:200 mg/kg.
scu-cat
LDLo:500 mg/kg, 25ppm;125
orl-hmn mg/m3
TCLo:50ppm/15M proposed 1974
TFX:EYE & IRR
ihl-hmn
Mod orl toxicity
LD50: 1299 mg/kg.
ipr-mus
LCLo:0.57 mg/kg, USDS air: TWA
orl-hmn 10ppm(skn)
LCLo:200 mg/m3/ or 1 1 mg/m3
10M, ihl hmn
LCLo:120mg/m3/
1H, ihl-hmn
Death through
asphyxia
LCLo:544ppm/5M,
ihl-rat
LC50:169ppm/30M,
ihl-mus
LD50:2.99 mg/kg,
ipr-mus
LDLo:3 mg/kg,
scu-mus
LD50:1.1 mg/kg,
ivn-mus
LD50:2.7 mg/kg.
244
DP
Hydroquinone
C6H4(OH)2
(C6H602)
000123319
(QR DQ)
370 rat
2)622
320 rat
3)73 &
4)547
400 mus
200 dog
70 cat
300 pgn
500 gpg
LDLo:29 mg/kg,
orl-hmn
High toxicity orl
and ihl. Active
allergen and a
strong irritant.
LD50:170 mg/kg,
ipr-rat
LDLo:300 mg/kg,
scu-rat
184
-------
Process
(Sources Process
of Compound) No.
Condensation 205
(Formaldehyde,
ammonia)
Hydrogenation 258
(Diacetone
alcohol, hydrogen.
catalyst)
Andrussow Process 166
(Methane, ammonia.
air, Pt/Rh catalyst)
Total
Waste Production
Associated Wastes Treatment 10^ kg/year
Air: formaldehyde. Centrifuge. 45.7/1973
ammonia, methanol If off-gases
Water: formaldehyde, are incinerated.
ammonia, methanol, NOX will be
hexamethylenetetra- produced
mine
Emission factors:
methanol - 5.0,
NH3-5.0,
formaldehyde - 3.0
Air: diacetone — 10.9/1973
alcohol, H2, acetone
Air: possible emissions — 138.1/1973
are ammonia, methane.
SO2, HCN, CO
Water: ammonium sul-
fate, sulfuric acid
Uses
52% catalyst in phenol-
formaldehyde &
resorcinolformaldehyde
resins; 40% high
explosive-cyclonite;
ingred in rubber-to-
textile adhesives; protein
modifier; organic syn-
thesis; Pharmaceuticals;
fuel tablets
Manufacturing; mainly
acetone cyanohydrin
(synthesis methyl
methacrylate), also
adiponitrile, chelating
agents (NTA, EDTA),
sodium cyanide, cyanuric
chloride, dyes; fumigant
for orchards & tree crops;
chelates
References
1)508
2)455
3)721
6)608
9)199
12)
13)39
1)629
2)620
3)890
4)531
9)203
1)425
2)470
3)728
5)561
7)6-583
13)39
Most HCN (70-90%)
produced and used
captively
(p-Benzoquinone,
iron dust, water)
16 Possible sludge, start- —
ing materials, phenolic
resins
Emission factors:
hydrocarbons - 2.0,
quinone - 1.0
8.1/1973 Photo developer (except
color film); dye inter-
mediate; medicine;
antioxidant; inhibitor;
stabilizer in paints &
varnishes, motor fuels
& oils; antioxidant for
fats & oils; inhibitor of
polymerization
1)77
2)472
3)731
4)547
7)11-469
9)23
12)
Continued)
185
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
244 (Continued)
LD50:115 mg/kg,
ivn-rat
LDLo: 100 mg/kg,
ipr-mus
LD50:190 mg/kg,
scu-mus
LD50:125 mg/kg,
ipr-rbt
245
Isoamyl alcohol
(1-Butanol, 3-
methyl)
(C5H120)
000123513
(Q2Y)
1300 rat
7070 rat
LDLo: 4250
rbt
LDLo:50 mg/kg.
orl-hmn
TCLo:150ppm
TFX:IRR, ihl-hmn
LDLo:813 mg/kg.
ipr-rat
LD50:3970 mg/kg.
skn-rbt
USDS air: TWA TDLo:27 gm/kg/l
100 ppmor 360 TFX:CAR, orl-rat
mg/m3 TDLo:3.8 gm/kg/l
TFX:CAR,scu-rat
246 Isoamyl chloride
(Butane, 1n:hloro-3-
methyl-)
(CH3)2CHCH2CH2CI
(C5HnCI)
000107846
(G2Y)
Unknown
247 Isoamylene
(1-Butene, 2-methyl-)
CH3CH2C(CH3>=CH2
(C5H10)
000563462
(1Y1U1)
Simple asphyxiant
248
DP
Isobutanol
(Isobutyl alcohol)
(CH3)2CHCH2OH
000078831
(Q1Y)
2460 rat
LDLo:3750
rbt
LDLo:500 mg/kg,
orl-hmn
LCLo:8000ppm/4H,
ihl-rat
LD50:4240 mg/kg,
skn-rbt
USDS air: TWA
100 ppmor 300
mg/m3
TDLo:29 gm/kg/l
TFX:CAR, orl-rat
TDLo:9 gm/kg/l
TFX:CAR,scu-rat
249 Isobutyl acetate
(Acetic acid, isobutyl
ester)
C4H9))CCH3
(C6H1202)
- Butyl acetate, see 66
000110190
(1Y10V1)
15,000 rat
4763 rbt
LCLo:8000ppm/4H,
ihl-rat
USOS air: TWA
150 ppmor 700
mg/m3
186
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
See amyl alcohols,
26
244
Photo chemical; organic 1 )592
synthesis; pharmaceutical 2)242
products; medicine; sol- 3)748
vent; determination of fat 5)561
in milk; microscopy;
flavoring
See amyl chlorides,
28
242
(Mixtures, usually also 1)588
containing normal amyl 3)748
chloride); solvent (nitro-
cellulose, varnishes,
lacquer, neoprene); roto-
gravure inks; soil fumigation;
organic compounds
Extraction
(Cs hydrocarbons,
sulfuric acid,
sodium hydroxide,
hexane)
246
Water: kg/mg
sodium hydroxide
(3.05), sodium sul-
fate (14.0), n-
hexane (19.0)
Water separa-
tion vessel
Organic synthesis; dental
& surgical anesthetic;
high octane fuel
manufacturing
1)595
3)811
Hydrogenation
(Isobutyraldehyde,
hydrogen, Ni or
Cu chromite or
MoS)
279
See n-butanol
Process 282
60.2/1973 25% solvent - mostly 1 )669
acetate in paints & 2)493
lacquers, 25% lube oil 3)749
additive; 10% inter- 5)561
mediate for amino coat- 7)3-828
ing resins; substitute for 9)203
n-butyl alcohol, paint 13)39
removers; fluorometric
determinations
Esterification 280
(Isobutyl alcohol.
acetic acid, sul-
furic acid)
Water: isobutyl
acetate, isobutyl
alcohol, acetic
acid, sulfuric acid
Air: isobutyl
acetate, isobutyl
alcohol
— 5.3/1972 Solvent for nitrocellulose
in thinners, sealants, &
topcoat lacquers; per-
fumery; flavoring agent
1)671
2)28
3)749
5)561
(Continued)
187
-------
TABLE A-1. (Continued)
Item
No.
250
Compound
Name and
Formula
Isobutyraldehyde
(Isobutylaldehyde)
(CH3)2CHCHO
(C4H80)
Chem. Abstr.
Registry No.
(WLN)
000078842
(VHY)
Oral Toxicity,
LDgo, mg/kg
28 10 rat
2)494
3700 rat
4)582
Toxicology TLV
Anesthetic; irr to —
eyes & muc mem of
the respiratory tract
LCLo:8000ppm/4H,
ihl-rat
Carcinogen
251
Isobutyric acid
(CH3)2CHCOOH
(C4H802)
000079312
(QVY)
280 rat Toxicity high orl &
skn
LD50:500 mg/kg,
skn-rbt
252 Isodecanoic acid 028933597
(CH3)2CHC6H12C02H (QV6Y)
Unknown
253 Isodecanol
(Isodecyl alcohol)
(CH3)2CHC7H14OH
(C10H220)
025339177
(Q7Y)
Toxicity moderate
orl & skn
254
Isoctyl alcohol
C8H17OH
-------
Process
(Sources Process Waste
of Compound) No. Associated Wastes Treatment
See n- 278
Butyraldehyde
Oxidation 281 Water: Isobutyralde- —
(Isobutyraldehyde, hyde, isobutyric acid,
air) isobutanol (if used).
Total
Production
TO** kg/year Uses References
173.6/1974 Intermediate for rubber 1)667
antioxidants & accelera- 2)494
tors, for neopentyl 3)749
glycol; organic synthesis 4)582
12)
— Manufacturing of esters 1)673
for solvents, flavors, & 2)494
perfume bases; disinfecting 3)750
Air: isobutyraldehyde
agent; deliming hides; var-
nish; tanning agent
Intermediate for metal 3)751
salts, ester type lubricants, 7)6-827
plasticizers; dental
material
Oxo Process
(Nonene, synthesis
gas, cobalt naph-
thenate catalyst,
then hydrogen and
Ni or Cu chromite
catalyst)
265 Same type pollutants
as Processes 187 & 188
79.2/1973 Antifoaming agent in 1)642
81.7/1974 texti le processing; plasti- 2)495
cizers; synthetic lubri- 3)751
cants; uranium refining; 7)1-568
solvent
Oxo Process
(Heptene, rest
same as 253 above)
266 Ditto
Emission factors:
H2- 10.0, CO -3.0,
isooctyl alcohol -
1.0, aldehydes - 1.0
55.4/1967 Almost 100% synthesis
22.4/1973 of plasticizers (primarily
phthalate)
1)644
2)498
7)
9)203
12)
13)40
Condensation &
dehydration
(Acetone, calcium
oxide, hydroxide or
carbide catalyst)
262 Air: acetone, mesityl
oxide, diacetone
alcohol, isophorone
In solvent mixtures for 11635
finishes; for polyvinyl & 2)329
nitrocellulose resins; 3)753
pesticides; stoving 5)561
lacquers
Oxidation 361
(m-Xylene, air.
acetic acid solvent.
bromine promoted
cobalt salt
catalyst)
Water: isophthalic
acid, terephthalic
acid, acetic acid
Emission factors:
CO -21.0, hydro-
carbons - 4.0
— 53.6/1974 Polyester, alkyd, poly- 1)833
urethane, & other high 2)499
polymers; plasticizers; 3)753
automotive industry; modi 7)15^461
modifiers in fiber films, 12)
& adhesives
(Continued)
189
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
257
Isoprene 000078795
CH2C(CH3)CHCH2 (1UY1U1)
(C5H8)
— Irr to muc mem of — —
eyes, nose & upper
respiratory tract;
no data on hmn
exposure
LD50:144mg/l
air, ihl-mus
Ditto
Ditto
Ditto
258 Isopropyl acetate
(Acetic acid,
isopropyl ester)
CH3COOCH(CH3)2
(C5H1002)
000108214
(1YOV1)
3000 rat
TDLo:200ppm
eye-hmn
Narcotic in high
concen
LDLo:32,000 ppm
ihl-rat
USDS air: TWA
250 ppm or 950
259
Isopropyl alcohol
(2-propanol)
CH3CHOHCH3
(C3H80)
000067630
(QY)
5840 rat
LDLo:192
mus
LDLo:6150
dog
TCLo:400 ppm,
TFX:IRR, ihl-hmn
Local-irr & in
high concen a
narcotic; absorbed
by the skn
LD50:933 mg/kg,
ipr-mus
LD100:6000 mg/kg,
scu-mus
LDLo:1963 mg/kg,
ivn-cat
LD50:16000 mg/kg,
skn-rbt
LDLo:6 mg/kg,
scu-mam
USOS air: TWA
400 ppm or 300
mg/m3
260
DP
Isopropylamine
(CH3)2CHNH2
(C3HgN)
000075310
(ZY)
820 rat Strong irr, sometimes
sensitizes; narcotic
in high concen
LDLo:800ppm/8H,
ihl-rat
LCLo: 7000 ppm/
40M, ihl-mus
LD50:550 mg/kg,
skn-rbt
USOS air: TWA
5 ppm or 12 iip
mg/m3
190
-------
Process
(Sources Process
of Compound) No.
Dehydrogenation 247
(Isoamylenes, iron
oxide, <2CO3,
0203 catalysts)
Dehydrogenation 248
(Cg hydrocarbons
(isopentane).
chromia-alumina
catalyst)
See ethyl acetate 103
Sulfation and hydro- 267
lysis, indirect hydra-
tion
(Propylene, sulfuric
acid, sodium
hydroxide)
Ammonia 271 A
alkylation
(Isopropyl alcohol.
ammonia, aluminum
phosphate catalyst)
Reductive am inono- 27 1B
lysis (Acetone,
ammonia, hydrogen.
Raney Ni catalyst)
Waste
Associated Wastes Treatment
Water: kg/Mg Absorber,
Isoprene (0.5), stripper.
amylenes (1.5) debutanizer.
Air: kg/Mg Shell aceto-
acetonitrile (5.0) nitrile pro-
Emission factors: cess
hydrocarbons - 2.0 purifier
Ditto Ditto
Emission factors: —
isopropylacetate - 1 .0
isopropanol - 1 .0
Air: possible Scrubbers,
propytene hydrolyzer -
Water: isopropyl stripper.
ether, hydro- decanter
carbons, pro-
panoic acid,
isopropanol,
caustic soda
Air: isopropyl Strippers
alcohol, isopropyl-
amine, ammonia
Water: ammonia.
isopropyl alcohol.
isopropylamine.
other amines
Air & Water: Ditto
acetone, NH3,
amines
Total
Production
1 06 kg/year Uses
151.8/1971 Monomer for manu-
182/1974 facturing of polyiso-
prene; chemical
intermediates
„
— Solvent for nitrocellulose.
resin gums, etc.; paints.
lacquers, & printing inks.
organic synthesis
833/1973 55% manufacturing of
869/1974 acetone & its derivatives.
777/1978 2% amines, 3% glycerol.
2% isopropyl acetate;
8% coatings solvents;
3% rubbing alcohol; 3%
de icing ingred; 3% drugs
& cosmetics; solvents
for essential & other oils,
alkaloids, gums, resins,
etc.; latent solvents for
cellulose derivatives;
aerosols; extraction pro-
cesses; dehydrating agent;
preservative
— Solvent: intermediate in
synthesis of rubber
accelerator, Pharmaceuti-
cals, dyes; insecticides;
bactericides, textile
specialties, & surface-
active agents; dehairing
agents; solubilizer for
2,4-D acid
__
References
1)6-769
2)499
3)753
4)589
7)12-79
12)
1)599
1)279
3)754
5)561
12)
1)560
2)499
3)754
4)590
5)561
6)638
7)16-575
9)203
10)
13)40
1)653
2)500
3)754
5)561
7)2-123
__
(Continued)
191
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD50' mg/kg
Toxicology
TLV Carcinogen
261 Isopropyl chloride
(propane, 2-chloro-!
CH3CHCICH3
(C3H7CI)
000075296
(GY)
Anesthetic; animal
studies suggest
moderate systemic
toxic ity
262 Isopropylphenol, o&p
(phenol, p-isopropyl)
(CH3)2CHC6H4OH
(C9H120)
(QR XY)
000099898
(QR DY)
See phenol
LDLo:250 mg/kg,
ipr-mus
263
Ketene
CH2CO
(C2H20)
000463514
(OCU1)
1300 rat Pulmonary edema
LCLo:23ppm/30M,
ihl-mus
LCLo:53ppm/
100M, ihl-rat
LCLo:53ppm/4H,
ihl-gpg
LCLo:200 ppm/
10M, ihl-mky
USDS air: TWA
0,5 ppm or
0.9 mg/m3
264 Maleic acid
HOOCCHCHCOOH
(C4H4O4)
000110167
(QV1U1VQ-
C)
708 rat
2400 mus
LD50:1560 mg/kg,
skn-rbt
Ditto
Ditto
Ditto
Ditto
265
Maleic anhydride
OCOCHCHCO
(C4H203)
000108316
(T5VOVJ)
60 mus
465 mus
481 rat
LDLo:850
rat
I hi toxicity high -
pulmonary edema.
Burns skin, eyes,
& muc mem
USDS air: TWA TDLo:610 mg/kg/
0.25 ppm or 61W
1 mg/m3 TFX:CAR, scu-rat
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
192
-------
Process
(Sources
of Compound)
Substitution,
Chlorination
(Isopropyl alcohol,
hydrochloric acid)
Process
No.
268
Associated Wastes
Air & Water: iso-
butyl alcohol,
isopropyl chloride,
hydrogen chloride
Total
Waste Production
Treatment 106 kg/year
— —
Uses
Solvent; intermediate;
isopropylamine
References
1)648
3)755
Friedel-Crafts
Reaction
(Phenol, isopropyl
chloride. Aids, BF3
or H2SO4 catalyst)
272 Air: May contain
HCI scrubber.
HCI, isopropyl, still bottom
chloride, byproducts tars incinerated
Water: NaCI, NaOH,
phenol, isopropyl
chloride, isopropyl
phenol, spent
catalyst
Intermediate for synthesis 1)655
resins, plasticizers, sur- 2)645
face active agent, perfumes 3)757
Pyrolysis
(Acetone)
263A Air: methane, acetone,
acetic acid
Acetylating agent gen-
erally reacting with com-
pounds having an active
hydrogen atom; reacts
with ammonia to give
acetamide; starting point
for making various
commercially important
products, especially acetic
anhydride & acetate esters
1)637
2)509
3)761
5)561
See maleic anhy- 41
dride. Process 38
(Maleic anhydride,
water)
See phthalic 220 &
anhydride 360
Oxidation 38
(Air, benzene.
vanadium
pentoxide on
carrier catalyst)
Oxidation 61
(Butenes, air.
Mo, Va, Poxide
catalysts on
silica gel)
— —
Air: benzene (131 kg/ —
Mg), CO (780 kg/Mg),
maleic acid
Water: kg/Mg
maleic anhydride (3.8),
high boilers (27),
maleic acid (0.6)
Emission factors: CO
1560, benzene -262.0
Air: butenes, CO, C02, —
maleic acid
Water: maleic
anhydride, maleic acid.
high boilers
— Organic synthesis (maleic.
succinic, aspartic, tartaric.
propionic, lactic, malonic,
acrylic, hydracrylic acids);
dyeing & finishing of
cotton, wool & silk; pre-
servative for oils & fats
— Ditto
128/1973 50% manufacturing poly-
132/1974 ester resins; 15% fumaric
151/1978 acid; 10% pesticides; 5%
alkyd resins; preservative
for oils & fats; paper;
permanant-press resins
(textiles); plastics; lubri-
cants; copolymers
Ditto Ditto
1)131
2)521
3)784
Ditto
1)125
2)521
3)785
5)561
6)639
7)12-832
11)37
12)
13)40
1)176
(Continued)
193
-------
TABLE A-1. (Continued)
Item
No.
266
Compound
Name and
Formula
See above item
Malic acid
HO2CCHOHCH2C02H
(C4H605)
Chem. Abstr.
Registry No.
(WLN)
See above
item
006915157
(QVYQIVA-
L)
Oral Toxicity,
LDgQ, mg/kg Toxicology
See above See above item
item
LDLo:1600 Moderate toxicity
rat
LDLo:5000
rbt
TLV Carcinogen
See above item See above item
267 Mesityl oxide
(3-Penten-2-one,
4-methyl-)
(CH3)2CCHCOCH3
(C6H100)
000141797
(1YU1V1)
1120 rat
1000 rbt
LCLo:25 ppm
TFX:IRR,ihl-hmn
Moderate toxicity
based in animal
studies. Narcotic
in high concen;
injury to liver,
kidneys & lungs.
Readily absorbed
through skn
LCLo: 1000 ppm/
4H, ihl-rat
LD50:354 mg/kg,
ipr-mus
USDS air: TWA
25 ppm or 100
268 Methacrylicacid
CH2(CH3)CCOOH
(C4H602)
000079414
(QVYU1)
Highly irr to skn,
eyes, muc mem
LD50:48 mg/kg,
ipr-mus
Ditto
Ditto
Ditto
269
Methacrylic esters
CH3CH2CCOOR
Methyl methacrylate,
see 64ADD
194
-------
Process
(Sources Process
of Compound) No. Associated Wastes
See phthalic 220 & —
anhydride 360
Hydration 42 —
(Maleic acid,
H20,02, Co
catalyst)
Dehydration 259 Water: acetone.
(Diacetone diacetone alcohol
alcohol, sul-
furic acid)
Total
Waste Production
Treatment 1 0^ kg/year Uses
— — Ditto
Ion exchanger — Mainly food acidu-
lant; medicine; manu-
facture of various
esters & salts; wine
manufacture; chela-
ting agent; flavoring
— — Solvent for cellulose
esters & ethers, oils.
gums, resins, lacquers,
roll-coating inks,
References
—
1)133
3)521
3)785
7)12-847
13)40
1)630
2)623
3)799
5)561
stains, ore flotation;
paint & varnish re-
movers; insect
repellent
Oxidation
(Isobutylene,
nitric acid.
possibly
N2O4)
Hydrolysis
(Acetone
cyanohydrin.
sulfuric acid.
water, inhibitors)
Esterification
(Acetone cyano-
hydrin, sulfuric
acid, alcohols.
inhibitors)
66 Air: Presumed
isobutylene and
oxidation
products
171 Air: Trace
methacrylic acid
Water: Meth-
acrylic acid,
inhibitors
172 Air: methacrylic
acid, alcohol
Water: mg/l
COD - 1.78 x 105
BOD5-2.07x 105
TOC-6.99x 105
methacrylic acid.
alcohols, inhibitors
— 30.9/1968 Monomer for large vol-
ume resins & polymers;
organic synthesis, many
of the polymers are
based on esters of the
acid, as the methyl,
butyl, or isobutyl esters
(see acrylic resin)
Acid stripper Ditto Ditto
rectifier, wash
column
— 321/1973 Almost all polymers &
(Methyl copolymers
meth-
acrylate)
1)184
2)533
3)800
4)668
1)433
1)435
(Continued)
195
-------
TABLE A-1. (Continued)
Item
No.
270
Compound
Name and
Formula
Methacrylonitrile
(2-Propenenitrile,
2-methyl-)
H2CCCH3CN
(C4H5N)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50,mg/kg
000126987 250 rat
(NCYU1) LDLo:15
mus
Toxicology TLV Carcinogen
Poison USDS air: TWA
LC50:328 ppm/4H, 1 ppm (skn)
ihl-rat
LC50:36ppm/4H,
ihl-mus
LDLo:15 mg/kg.
ipr-mus
LC50:37 ppm/4H,
ihl-rbt
LD50:320 mg/kg.
skn-rbt
271 Methallyl alcohol
(2-Propen-1-ol,
2-methyl)
CH3CHCHCH2OH
(C4H80)
000513428
(Q1YU1)
LDLo:500
mus
LCLo:2924ppm/2H,
ihl-mus
LDLo:2000 mg/kg,
skn-rbt
272 Methallyl chloride
(Propene, 3-chloro-
2-methyl)
CH3CHCHCH2CI
(C4H7CI)
000563473
(G1YU1)
LC50:2000 mg/m3/
24H, ihl-rat
LCLo:9100 mg/m3/
10M ihl-mus
273 Methyl acetate
(Acetic acid, methyl
ester)
(C3H602)
000079290
(1V01)
3700 rbt
LDLo: 4800
rat
Narcotic; irr to muc
mem of eyes &
upper respiratory
tract
LDLo:80mg/m3/
31M, ihl-mus
LCLo:67 mg/m3/
56M, ihl-cat
LDLo:3000 mg/kg,
scu-cat
LDLo:3000 mg/kg,
scu-gpg
USDS air: TWA
200 ppm or
610 mg/m3
Ditto
Ditto
Ditto
Ditto
Ditto
274 Methyl acetoacetate
DP (Acetoacetic acid,
methyl ester)
CH3COCH2COOCH3
(C5H803)
000105453
(1V1V01)
3000 rat
Unknown
196
-------
Process
(Sources
of Compound)
Ammoxidation
(Isobutylene,
ammonia, air)
Process
No. Associated Wastes
65 Air: kg/Mg
methacrylonitrile (5),
CO (200), isobutylene
(100), HCN (1),
ammonia (trace)
Water: ammonium
sulfate, possibly
acetonitrile
Total
Waste Production
Treatment 10^ kg/year
Absorber off —
gas to flare
Uses
Vinyl nitrile monomer;
copolymer with styrene.
butadiene, etc.; elasto-
plastics
References
1)182
2)765
3)800
Substitution,
Hydrolysis
(Methallyl chloride,
sodium hydroxide,
H20)
64 Water: NaOH, NaCI,
methallyl alcohol,
methallyl chloride
Intermediate
1)181
2)766
3)800
Chlorination
(Isobutylene,
chlorine)
63 Air: Some C\2 and
HCI may occur
Heavy ends may
be incinerated
Intermediate for pro- 1 )180
duction of insecticides, 2)765
plastics, pharmaceutical, 3)800
other organic chemicals; 7) 10-728
fumigant for grains,
tobacco, & soil
Esterification
(Methanol, acetic
acid, sulfuric acid
catalyst)
194 Water: methyl
acetate, methanol,
acetic acid, sulfuric
acid
Air: methanol,
methyl acetate
Emission factors:
methanol - 1.0
methyl acetate - 1.0
Paint remover com- 1)487
pounds; lacquer solvent, 2)30
intermediate, solvent for 3)805
cellulose nitrate, cellulose 5)561
acetate, resins & oils; 7)8-378
artificial leather 12)
See acetic acid
227
Ditto
1)560
Claisen Reaction,
Sodium fusion
(Methyl acetate,
sodium, methanol
solvent, sulfuric
acid)
195 Air: hydrogen
Water: sodium salts,
methanol, sulfuric
acid
Solvent for cellulose
ethers; ingred of solvent
mixtures for cellulose
esters; organic synthesis
1)489
2)35
3)805
(Continued)
197
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q, mg/kg
275 Methyl alcohol 000067561 LDLo:420
(Methanol) ,Q-, mus
LDLo:7500
dog
LDLo:7500
rbt
Toxicology TLV Carcinogen
LDLo: 340 mg/kg, USOS air: TWA —
orl-hmn 200 ppm or
TDLo: 100 mg/kg, 260 mg/m3
TFX:EYE, orl-hmn
TCLo:300 ppm
TFX:CNS, ihl-hmn
Narcotic; slight
irr to muc mem;
CNS effects;
coma; cumulative
poison
LDLo: 1800 mg/kg.
ipr-rat
LD50:9800 mg/kg,
scu-mus
LC50: 1000 ppm.
ihl-mky
276
DP
Methylamine
CH3NH2
(CH5N)
000074895
(Z1)
Strong irr
LDLo:2500 mg/kg,
scu-mus
LDLo:2000 mg/kg,
scu-frg
USOS air: TWA
10 ppm or 12
mg/m3
277 M-Methylaniline
(Aniline, N-methyl)
C6H5NHCH3
(C7H9N)
000100618
(1MR)
LDLo: 280
rbt
LDLo: 1200
9P9
Both liquid &
vapor can be ab-
sorbed through
the skn
LDLo:24 mg/kg,
ivn-cat
LDLo:24 mg/kg,
ivn-rbt
LDLo:1200 mg/kg,
scu-gpg
USOS air: TWA
2 ppm (skn) or
9 mg/m3 (skn)
Ditto
Ditto
Ditto
Ditto
Ditto
198
-------
Process
(Sources Process
of Compound) No.
Total
Waste Production
Associated Wastes Treatment 10^ kg/year
Uses References
(Synthesis, or
syn gas - CO+2H2,
Cr & Zn oxide
catalysts)
191 Water: oils, methanol,
higher boiling organic
compounds
Plant 1:
Flow - 0.492 m3/kg
COD - 320 mg/l
-0.16g/kg
BOD5- 119 mg/l
- 0.059 g/kg
TOC - 107 mg/l
- 0.053 g/kg
Plant 2:
Flow-0.352 m3/kg
COD - 4930 mg/l
- 1.74 g/kg
BOD5-2620 mg/l
- 0.92 g/kg
TOC - 583 mg/l
-0.21 g/kg
Solvent for cellulose 11489
ethers; ingred of solvent 2)35
mixtures for cellulose 3)805
esters; organic synthesis
Ammonolysis
(Methanol,
ammonia
alumina catalyst)
192 Air: hydrogen, carbon
monoxide, methylamines
Water: methylamine,
dimethylamine, tri-
methylamine
16.8/1973 Manufacture: 11% Sevin 1)481
24.9/1974 insecticide, 8% surfactants 2)550
(e.g., acylmethyltaurins 3)840
salts), rocket propellent 5)561
(Methyl hydrazine); 7)2-122
intermediate for accelera- 9)200
tors, dyes, pharmaceuti- 10)
cals, fungicides, surface 13)41
active agents, tanning;
dyeing acetate textiles;
fuel additive; polymeriza-
tion inhibitor; component of
paint removers
Alkylation
(Aniline, methanol,
hydrogen, alumina/
CaO2 catalyst)
12 Air: methanol, aniline,
methylaniline, N,N-di-
methylaniline
Organic synthesis; solvent; 1)71
acid acceptor 2)98
5)561
Alkylation 14 Water: Nal, NaOH, Acid scrubber
(Aniline, methyl methyl iodide, aniline,
iodide) methyl-aniline,
dimethylaniline
Air: methyl iodide, HI
Ditto
1)73
3)910
(Continued)
199
-------
TABLE A-1. (Continued)
Item
No.
278
Compound
Name and
Formula
Methybutynol
(3-Butyn-2-ol,2
methyl-)
(CH3)2COHCCH
(C5H80)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg Toxicology TLV
000115195 — LD50: 3600 mg/kg.
(QX1UU1) ipr-mus
Carcinogen
279
Methyl chloride
(Methane, chloro)
CH3CI
000074873
(G1)
Slight irr & narcotic;
CNS damage from
exposure to high
concentrations or
repeated exposure;
some liver, kidney,
bone marrow &
cardiovascular dam-
age. Death may occur
immediately or
several days after
exposure
LC50:3146 ppm/7H
ihl-mus
LCLo:15,000 ppm/
7H ihl-dog
LDLo: 128,700 mg/m3/
4H i hi-cat
LCLo:3000ppm/4H,
ihl-rat
LCLo: 20,000 ppm/
2H, ihl-gpg
USOS air: TWA
100 ppm; or 210
mg/m3; CL 200
ppm; PK 300
ppm/5M/3H
Ditto
Ditto
Ditto
Ditto
280 Methylcyclohexane
(Cyclohexane, methyl)
CH3C6HH
000108872
(L6TJA)
LCLo: 4000
rbt
LDLo:500 mg/kg,
orl-hmn
Lethal in high
concen. Narcosis
& anesthesia in
sublethal doses
USOS air: TWA
500 ppm or
2000 mg/m3
281 Methylcyclohexanol
(Cyclohexanol, methyl)
CH3C6Hi0OH
(C7H140)
025639423
1660 rat
LDLo:1750
rbt
TCLo:500 ppm
TFX:IRR, ihl-hmn
LD50:2900 mg/kg,
scu-rat
USOS air: TWA
100 ppm or
470 mg/m3
200
-------
Process
(Sources Process
of Compound) No.
Ethylnylation 177
(Acetylene,
acetone, ammonia.
sodamide catalyst)
Chlorination 157
(Methane, chlorine.
sodium hydroxide.
sulfuric acid)
Associated Wastes
Air: acetylene, •
ammonia, solvents
Water: salts & heavy
by products
Air: kg/Mg
CH4 (O.CHaCI (13),
CH2CL2 (2),CHCl3
(1), CCI4 (1)
Total
Waste Production
Treatment 1 06 kg/year
— —
HCI absorber, 247/1973
caustic washer 207/1974
206/1978
Uses
Stabilizer in chlori-
nated solvent; viscosity
reducer & stabilizer;
electroplating brightener;
intermediate; metal work-
ing; rubber cement;
perfumes
Manufacturing: 38%
chlorosilanes (silicone
intermediates), 38% tetra-
methyl lead; catalyst
References
1)446
3)812
7)1-624
1)404
2)536
3)813
5)563
Water: HCI, sodium
hydroxide, sulfuric
acid
Emission factors:
CH4 - 1 Ib/ton
CH3CI-13 Ib/ton,
CH2CI2 - 2 Ib/ton,
CHCI3 - 1 Ib/ton,
CCI4 - 1 Ib/ton
carrier in low-temperature 6)619
polymerization (butyl 7)5-110
rubber); 4% methylating 9)205
agent in organic synthesis, 10)
such as methylcellulose; 12)
4% herbicide, 3% quat- 13)41
amines; extractant & low-
temperature solvent, grow-
ing important as propellant
in high-pressure aerosols
Substitution,
Chlorination
(Methanol, HCI,
alumina gel or
other catalyst)
193
Ditto
Ditto
1)485
Hydrogenation
(Toluene, hydro-
gen, Ni or Pt
catalyst)
350
Air or Water:
Rearranged
hydrocarbons
Solvent for cellulose 1 )805
ethers; organic synthesis 2)326
3)815
5)561
Oxidation, Partial
Oxidation
(Methyl cyclohexane,
oxygen, metaboric
acid, catalyst, NaOH)
351 Air: some
cvclohexene
Water: spent caustic
and cyclohexanol
1)807
2)327
3)815
5)561
(Continued)
201
-------
, TABLE A-1. (Continued)
Item
No.
282
Compound
Name and
Formula
Methylcyclohexanone
(Cyclohexanone, 2-
methyl)
Chem. Abstr.
Registry No.
(WLN)
001331222
(L6VTJ B
*DXLV)
Oral Toxicity,
LD50, mg/kg
2140 rat
LDLo:1000
rbt
COCH(CH3)CH2CH2CH2CH2~
(C7Hi20)
Toxicology
Kidney & liver
damage
LD50:200 mg/kg
ipr-mus
TLV
USDS air: TWA
100ppm (skn)
or 460 mg/m3
(skn)
Carcinogen
283 Methyldioxolane
(Dioxolane, methyl)
OCH(CH3)OCH2CH2
001331095 3000 rat
Moderate oral toxi-
city
284 Methylene chloride
(Methane, dichloro)
(Dichloromethane)
CH2CI2
000075092
(G1G)
945 rat
2136 rat
LDLo:300
dog
LD100:1900
rbt
LD50:500 mg/kg,
orl-hmn
TCLo:500 ppm/
1YI,TFX:CNS,
ihl-hmn
TCLo:500ppm/8H,
TFX:BLD, ihl-hmn
Strong narcotic;
anesthetic; derma-
titis; dangerous to
the eyes
LC50:14,400 ppm/
7H, ihl-mus
LCLo: 20,000 ppm/
7H,ihl-dog
LD50:1500 mg/kg,
ipr-mus
LD50:6460 mg/kg,
scu-mus
LD100:950 mg/kg,
ipr-dog
LDLo: 2700 mg/kg,
scu-dog
LDLo:200 mg/kg,
ivn-dog
LDLo:2700 mg/kg,
scu-rbt
LCLo:5000ppm/
2H, ihl-gpg
USOS air: TWA
500 ppm; CL
1000 ppm ;PK
2000 ppm/5M/
2H
285 Methylenedianiline
DP (Aniline, 4,4'-
methylenedi-)
CH2(C6H4NH2)2
(C13H14N2)
000101779 347 rat
(ZR DIR
DZ)
TDLo:8.42 mg/kg,
orl-man
Moderately high
acute oral
toxicity
LD50:200 mg/kg,
scu-rat
TDLo:80 mg/kg,
TFX:CAR,orl-rat
TDLo:1410 mg/kg,
TFX:NEO, scu-rat
202
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
10^ kg/year
Uses
References
Oxidation,
Dehydrogenation
(Methyl cyclohexa-
nol, air, Ag or Cu
catalyst)
352
Air: methyl cyclo-
hexanol, methyl
cyclohexanone
Water: methyl
cyclohexanone
Solvent; lacquers; solvent 11809
for cellulose esters &
ethers for lacquers, anti-
oxidant for lubricants;
blending agent for
special textile soaps &
detergents
2)327
3)815
5)561
Condensation
(Ethylene glycol,
acetaldehyde,
acid catalyst)
148 Water: acetaldehyde,
ethylene glycol,
methyl dioxolane
Extractant & solvent for 1 )380
oils, fats, waxes, dyestuffs, 2)372
& cellulose derivatives 3)819
Chlorination 158 Air: kg/Mg
(Methane, CH4(1),CH3CI
chlorine) (13), CH2Cl2 (2),
CHCI3 (1),CCl4
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
286 Methyl ethyl ketone
2-Butanone
CH3COCH2CH3
(C4H8O)
000078933 3400 rat
(2V1)
LDLo:500 mg/kg,
orl-hmn
TCLo:100ppm/5M
TFX:IRR, ihl-hmn
Local irr & narcotic,
affects peripheral
nervous system
TCLo:1000ppm/
(6-15Dpreg)
TFX:TER,ihl-rat
LCLo:2000ppm/
4H, ihl-rat
LDLo:2000 mg/kg,
ipr-rat
LD50:616mg/kg,
ipr-mus
USDS air: TWA
200 ppm or
590 mg/m3
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
287
Methyl formate
(Formic acid,
methyl ester)
HCOOCH3
(C2H402)
000107313
(VH01)
1620 rbt LDLo:500 mg/kg, USDS air: TWA
orl-hmn 100 ppm or
Irr to eyes 250 mg/m3
LDLo: 10,000 ppm,
ihl-gpg
288 Methyl isobutyl
carbinol
(Methyl amyl alcohol)
(4-methylpentanol-2)
(CH3)2CHCH2CHOHCH3
(C6H140)
000105306 1410 rat
(Q1Y3)
TCLo:50 ppm, USDS air: TWA
TFX:IRR, ihl-hmn 25 ppm or 100
Strong irr; anesthesia mg/m3
LD50:3560 mg/kg,
skn-rbt
289 Methyl isobutyl
ketone
(2-Pentanone, 4-Methyl)
(CH3)2CHCH2COCH3
(C6H120)
000108101
(1Y1V1)
2080 rat
LDLo: 2850
LDLo:500 mg/kg,
orl-hmn
TCLo:200ppm,
TFXMRR, ihl-hmn
Irr to eyes & muc
mem; narcotic
USDS air: TWA
100 ppm or
410 mg/m3
204
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Oxidation, De-
hydrogenation
(See Butyl
alcohol, ZnO
catalyst)
56 Water: methyl ethyl
ketone, byproducts
230/1974 Solvent: 34% vinyl coat- 1)164
246/1973 ings, 14% nitrocellulose, 2)242
272/1978 14%adhesives, 12% 3)438
acrylic coatings, 7% misc 5)560
coatings, 7% lube oil 6)643
dewaxing, 6% misc in- 11)37
eluding alkyds; paint 12)
removers; cements & 13)41
adhesives; organic
synthesis cleaning fluids;
printing; catalyst carrier
See acetic acid
227
Emission factors:
n-butyl alcohol -
1.0
Ditto
Ditto
1)560
See allyl alcohol
(Acrolein, 2-
butanol, metal
oxide catalyst)
251B
1)616
Carbonylation,
esterification
(Methanol, syn
gas or CO+H2-
sodium methoxide
catalyst)
198
Air and Water:
dimethyl ether,
tars
Organic synthesis; cellu- 1)494
lose acetate solvent; 2)431
military poison gases; 3)822
fumigant; larvicides;
food additive for human
consumption
Hydrogenation
(Methyl isobutyl
ketone, hydrogen,
catalyst)
261
Air: methyl iso-
butyl ketone,
methyl isobutyl,
carbinol,
byproducts
15.9/1973 Solvent for dyestuffs; 1 )633
oils, gums, resins, waxes, 2)621
nitrocellulose & ethyl- 3)807
cellulose; organic 5)561
synthesis, froth flotation; 6)644A
brake fluids
Hydrogenation
(Mesityl oxide.
hydrogen, Cu or
Raney Ni
catalyst)
260 Air: mesityl oxide, —
methyl isobutyl ke-
tone, methyl isobutyl
carbinol, byproducts
Emission factors:
hydrocarbons - 84.6
70.3/1973 Solvent: 35% nitrocellu- 1)631
94.2/1 974 lose, 25% vinyl coatings & 2)622
inks; 10% pharmaceuti- 3)750
cals; 10% methyl iso- 5)561
butyl carbinol; 5% mag- 6)644A
netic tape; 4% adhesives; 1 2)
11% miscellaneous, 13)41
(Continued)
205
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
289 (Continued)
LCLo:4000 ppm/
15M, ihl-rat
LD50:268 mg/kg,
ipr-mus
290 Methyl pentynol
(1-Pentyn-3-ol,
3-methyl-)
HCCC(OH)CH3C2H5
(C6H100)
000077758 300 rat
(QX2&1UU1) 534spg
760 mus
2)625
698 mus
3)829
LDLo:500 mg/kg,
orl-hmn
TDLo:70 mg/kg,
TFX:CNS, orl-hmn
Soporific; average
doses may produce
dermatitis; eructa-
tions; psychoses &
CNS abnormalities;
overdoses produce
coma & death
LD50:750 mg/kg,
scu-mus
291 Methylphenylcarbinol
(Phenylmethylcarbinol)
(Ethanol, 1-phenyl)
(Benzy alcohol, a-methyl)
C6H5CH(CH3)OH
(C8H100)
000098851 400 rat
(QYR)
Limited animal
studies show low
toxic ity
LD50:2500 mg/kg,
skn-rbt
Methylsal icy late, see
66ADD
292 a-Methylstyrene
DP (Styrene, a-methyl)
C6H5-C3H5
(C9H10)
000098839
(1YR&U1)
4900 rat
TCLo:600ppm,
TFX:IRR, ihl-hmn
Immediate death
caused by action
on CNS; delayed
death due to
pnemonia
LCLo:3000 ppm,
ihl-rat
LCLo:3000ppm,
ihl-gpg
100 ppm;
480 mg/m3
293 Monopropylene glycol
(Propylene glycol)
(1,2-Propanediol)
CH3CH(OH)CH2OH
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
including 3% extraction
uranium from fission
products
Ethynylation,
Acetylation
(2-Bu^none,
acetylene,
dimethylacetal
of formaldehyde,
solvent alkali or
alkaline earth
oxide catalysts)
178 Air: reactants
Water: catalyst salts
and heavy
byproducts
Stabilizer in chlorinated 1)448
solvent; viscosity reducer; 2)625
electroplating brightening; 3)829
intermediate in synthesis
of hypnotics & isoprenoid
chemical; solvent for
polyamide resins; acid
inhibitors; prevention of
hydrogen embrittlement;
medicine (soporific &
anesthetic)
Grignard Reaction,
Addition
(Acetaldehyde,
benzene, bromine,
magnesium)
92
Air: Ether and
bromobenzene
Water: bromine,
hydrogen bromide,
sodium bromide,
sodium hydroxide
Perfumery; flavoring; dyes; 1)253
laboratory reagent 2)222
3)1017
Dehydrogenation
(Cumene, iron
oxide catalyst)
296 Water: aromatic
hydrocarbons, tars,
spent catalyst
Organic solid, 23.8/1973 Polymerization monomer, 1)701
from still 26.1/1974 especially for polyester; 2)875
bottoms foods; plasticizers for 3)832
incinerated paints, waxes, adhesives, 7)19-83
7 plastics 9)23
12)
See Dipropylene
glycol, 181
287 Emission factors:
propylene glycol -
3.0
228/1973
250/1978
52% manufacture poly-
ester resins; 8.5% cello-
phane; 7.5% tobacco
humectant; 7% plastici-
zers; 4% brake fluids;
emulsifiers & food add
1)684
2)745
3)943
12)
13)44
(Continued
207
-------
TABLE A-1. (Continued)
Item
No.
294
DP
Compound
Name and
Formula
Morpholine
OCH2CH2NHCH2CH2
(C4HgNO)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
000110918 1050 rat
(T6M DOTJ)
Toxicology
LDLo:50 mg/kg.
orl-hmn
LD50: 500 mg/kg.
skn-rbt
LD50:413mg/kg,
ipr-mus
TLV
USOS air: TWA
20 ppm (skn)
or 70 mg/m3
(skn)
Carcinogen
295
DP
Naphthalene
000091203
(L66J)
1780 rat LD Lo: 50 mg/kg,
orl-hmn
LDLo:100orl-
chd
Systemic reactions
include nausea,
headache, diaphore-
sis, hematuring
fever, anemia, liver
damage, convul-
sions, coma
LD50:150 mg/kg,
ipr-mus
USOS air: TWA TDLo:3500 mg/kg/
10ppm;50 98DI TFX:NEO,
mg/m3 scu-rat
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
296 1-Naphthalene
sulfonic acid
Ci0H7-SO3H-2H2O
-------
Process
(Sources Process
of Compound) No.
Total
Waste Production
Associated Wastes Treatment 106 kg/year
Uses References
Condensation,
Ammonolysis
(Diethanolamine,
sulfuric acid)
153 Water: diethanolamine,
extraction solvent,
morpholine, alkali
sulfate
Rubber accelerator & 1 )388
stabilizer; solvent; 2)560
organic synthesis; additive 3)841
to boiler water; waxes & 5)561
polishes; corrosion in- 7)13-665
hibitor; optical brightener
for detergents; lubricating
oil; wrapping paper; coat-
ing for fruits & vegetables;
Pharmaceuticals; bacteri-
cides; textiles; photochemi-
cals; gasoline additive;
herbicide
Separation, see
Acenaphthene
208 Air: May contain
paraffins, olefins,
low boiling aromatics,
furfural, S02
164/1973 57% manufacture phthalic 1)517
anhydride; synthesis: 20% 2)565
insecticide (1-naphthyl-N- 3)843
methyl carbamate), 9% 0- 5)561
naphthol, 7% tann ing 7)13-686
agents; 3% moth repellant; 9)11
1 % surfactants; misc. 13)42
plasticizers; dye inter-
mediate pigments
Hydrocarbon,
desulfurization
(Napthalene feed,
hydrogen, cobalt
molybdate
catalyst)
209 Air and Water: H2S,
NH3, mercaptans
Ditto
Ditto
1)519
Sulfonation
(Naphthalene,
sulfuric acid,
lime, soda ash)
217 Air: SC>2, naphtha-
lene
Water: calcium
carbonate, sodium
carbonate, sodium
sulfate, naphthalene,
naphthalene
sulfonates
Starting point in the
manufacture of alpha-
naphthol, alpha-
naphtholsulfonic acid,
alpha-naphthylamine-
sulfonic acid; solvent
(sodium salt) for phenol
in the manufacture of
disinfectant soaps
1)533
Sulfonation
(Naphthalene,
sulfuric acid,
sodium chloride,
water)
218
Water: sodium
chloride, sodium
sulfate, sodium
hydroxide
Starting point in the
manufacture of beta-
naphthol, beta-
naphtholsulfonic acid,
beta-naphthylamine-
sulfonic acid; leather
tanning agents
1)535
2)577
13)42
(Continued)
209
-------
TABLE A-1. (Continued)
Item
No.
298
DP
299
DP
Compound
Name and
Formula
1-Naphthol
(a-Naphthol)
C10H7OH
(C10H80)
2-Naphthol
(0-Naphthol)
C10H7-OH
(C10H80)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgg, mg/kg Toxicology TLV Carcinogen
000090153 2590 rat LDLo:50 mg/kg.
(L66J BQ) 380° rbt orl'hmn
In hmn large in-
gestions result
in nephritis, vom-
iting, diarrhea.
circulatory
collapse, anemia.
convulsions &
death. Abs
through skn may
cause kidney & eye
damage.
LD50:880 mg/kg.
skn-rbt
000135193 2420 rat LDLo:50 mg/kg.
(L66JCQ) LDLo:3800 orl-hmn
rbt See 1-naphthol
LDLo: 2940 mg/kg.
scu-rat
LDLo: 100 mg/kg.
scu-mus
LDLo:2670 mg/kg,
scu-gpg
1-Naphthylamine,
see 67ADD and 633,
Table B-2, Dye
Intermediates
300 Neopentanoic acid
(Pivalic acid)
(Trimethylacetic acid)
(CH3)3CCOOH
(C6H1002)
000075989
(QVX)
LDLo: 5000
rat
Ditto
Ditto
Ditto
o- and p-Nitroanilines,
see 97 & 98, Table B-2,
Dye Intermediates
301G
DP
Nitroanisole, o&p
(WNR X01)
210
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
Hydrolysis
(1-Naphthylamine,
sulfuric acid,
water)
212 Water: ammonium
sulfate, sulfuric
acid,
1 -naphthy lamine,
1-naphthol
Dyes; organic synthesis;
synthetic perfumes;
intermediates; Pharma-
ceuticals; insecticides
1)524
2)582
3)844
4)715
7)13-717
Substitution &
acidification,
fusion & decom-
position
(2-Naphthalene-
sulfonic acid,
sodium hydroxide,
sulfuric acid)
219
Water: sodium sul-
fate, naphthalene-
sulfonic acid,
naphthols
10.8/1955 Dyes; pigments; anti- 1)537
oxidants for rubber fats, 2)582
oils; insecticides; syn- 3)844
thesis of fungicides; 7) 13-717
Pharmaceuticals, per-
fumes; intermediate
Oxidation
(Tert-butyl alcohol,
formic acid, sul-
furic acid)
74A
Water: Reactants
and products,
H2SO4
I ntermediate, as a replace- 1) 198
ment for some natural 2)733
materials
Oxidation
(Isobutylene,
carbon monoxide,
sulfuric acid)
74B Air: CO, isobutylene
Water: HjSO^ crude
product
Ditto
1)198
Methylation
(o- and p- ii
nitrophenol, di-
methyl sulfate,
sodium hydroxide,
water)
309 Air: dimethyl sulfate, —
methane I
Water: dimethyl sul-
fate, methanol, sodium
hydroxide, sodium
sulfate
Organic synthesis; manu- 1 )726
facture of intermediates 2)102
for dyes & 3)856
Pharmaceuticals
211
-------
TABLE A-1. (Continued)
Item
No.
301
Compound
Name and
Formula
p-Nitroanisole
CH3O-C6H4-NO2
Chem. Abstr.
Registry No.
(WLN)
029191535
(WNR DO1)
Oral Toxicity,
LD50, mg/kg
4700 rat
Toxicology TLV
LD50: 1400 mg/kg,
ipr-man
Carcinogen
—
302
DP
Nitrobenzene
(Benzene, nitro)
C6H5NO2
000098953
(WNR)
640 rat
LDLo:700
rbt
LDLo:750
dog
LDLo:2000
cat
LDLo:5 mg/kg,
orl-hmn
TDLo:200 mg/kg,
TFX:BLD orl-wmn
Cyanosis due to
formation of
methemoglobin
LDLo:800 mg/kg,
scu-rat
LDLo:400 mg/kg,
skn-mus
LDLo: 150 mg/kg,
ivn-dog
LDLo:600 mg/kg,
skn-rbt
USDS air: TWA
1 ppm (skn) or
5 mg/m3 (skn)
303G Nitrobenzoicacid
DP (o, p, m)
NC-2C6H4COOH
(WNR
XVQ)
303 Benzoic acid, o-nitro 029809244
(WNR BVQ)
304 Benzoic acid, p-nitro 000062237 1960 rat
(WNR DVQ)
Animal studies
suggest moderate
toxicity
LD50:1210 mg/kg,
ipr-rat
LD50:1960 mg/kg,
par-rat
LD50:880 mg/.kg,
ipr-mus
LD50:1470 mg/kg,
ivn-mus
LD50:1470 mg/kg,
par-mus
305 Benzoic acid, m-nitro 000121926
(WNR CVQ)
LD50:670 mg/kg,
ipr-rat
LD50:680 mg/kg,
ivn-rat
LD50:1820 mg/kg,
par-rat
212
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10® kg/year
Uses
References
See item above
See
item
above
See item above
See item above
See item
above
Nitration
(Benzene, sul-
furic acid,
nitric acid,
sodium
carbonate)
25
Air: kg/Mg
benzene (8.2)
NOX (0.25)
Water: benzene,
nitrobenzene
Acid 140.1/1973 97% manufacture aniline; 1)97
separator 3% solvent (e.g., cellulose 2)161
ethers & a selective solvent 3)857
in the petroleum industry) 4)737
& synthetic dichloro- 5)562
anilines; dyes; ingredient 6)608
of metal polishes & shoe 7)13-840
polishes; manufacture of 9)23
benzidine, quinoline, 13)42
azobenzene; lubricating
oil; rubber chemical; photo
chemicals; drugs; solvent
for Friedel Crafts reactions
Oxidation
(Nitrotoluene,
permanganate
for ortho,
chromic acid for
meta and para)
339
Water: chromium
or potassium salts
Organic synthesis, prepara- 1)764
tion of anesthetics & as 3)857
intermediate in the manu-
facture of dyes & sun-
screening agents
Ditto
See above
Ditto
Water: Potassium
salts
Ditto
1)764
Ditto
See above
Ditto
Water: Chromium
salts
Ditto
1)764
2)195
3)857
Ditto
See above
Ditto Water: Chromium
salts
Ditto
1)764
2)195
3)857
(Continued)
213
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
305 (Continued)
LD50:610 mg/kg,
ipr-mus
LD50:640 mg/kg,
ivn-mus
LD50:1290 mg/kg,
par-mus
See above item
See above
item
See above item
306 Nitroethane
(Ethane, nitro-)
(C2H5NO2>
000079243
(WN2)
11 00 rat
860 mus
LDLo:500
rbt
Injury to liver &
kidneys of experi-
mental animals
USDS air: TWA
100 or 310
mg/m3
307
Nitromethane
(Methane, nitro-)
(CH3NO2)
000075525
(WN1)
940 rat
950 mus
LDLo:125
dog
LDLo:750
rbt
LDLo:500 mg/kg,
orl-hmn
May cause anorexia,
nausea, vomiting,
& diarrhea in hmn;
kidney & liver
damage
LDLo:565 mg/kg,
scu-dog
LDLo:800 mg/kg,
ivn-dog
LCLo:2446 mg/m3
ihl-mky
LDLo:750 mg/kg,
ivn-rbt
USDS air: TWA
100 ppm or
250 mg/m3
1 -Nitronaphthalene,
see 498, Table B-2,
Dye Intermediates
308G
DP
Nitrophenol
(3 isomers)
(C6H5N03)
(WNR XQ)
214
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Nitration
(Benzoic acid,
nitric acid, sul-
furic acid)
329 Air: NOX
Water: Benzoic acid
m-nitrobenzoic acid
See above item
1)766
Nitration 237 Air: above plus CO,
(Propane, NOX, propane
nitric acid. Water: aldehydes,
water, air) ketones, acids,
alcohols, olef ins
Propellant; solvent for 1)578
nitrocellulose, cellulose 2)390
acetate, cellulose ace- 3)859
topropionate, cellulose 5)562
acetobutyrate, vinyl, 7)13-879
alkyd, & many other
resins, waxes, fats &
dyestuffs; chemical
synthesis
See nitroethane
(Same as nitro-
ethane plus
oxygenated sul-
fur compound)
237
Explosives; propellants;
fuels; solvents
1)578
2)538
3)863
5)562
7)13-879
Nitration
(Phenol, nitric
acid)
307 Water: dinitrophenols,
trinitrophenols,
oxalic acid, nitric
acid, phenol,
p-nitrophenol
Emission factors:
phenol - 2.0,
N02-2.0
nitrophenol - 1.0
Synthesis of o-
aminophenol & o-
nitroanisole; dye
intermediate
1)722
7)13-889
12)
(Continued)
215
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
308 Phenol, o-nitro
000088755
(WNR CO)
2828 rat
1297 rat
2080 mus
Liver & kidney
damage in experi-
mental animals
LDLo:100 mg/kg,
ivn-dog
309 Phenol, p-nitro
DP
000100027
(WNR DQ)
350 rat
467 mus
Hyperthemia,
methemoglobin-
emia & CNS
depression
LD50:75 mg/kg,
ipr-mus
LDLo: 10 mg/kg,
ivn-dog
LDLo:65 mg/kg,
ims-pgn
— Phenol, m-nitro
00055487 447 rat
(WNR BQ)
1414 mus
High orat toxicity
LDLo:83 mg/kg,
ivn-dog
310G Nitropropanes
CH3CH2CH2NO2
C3H7N02)
310 Propane, 1-nitro
000108032 800 mus
(WN3)
LDLo:250
rbt
LDLo:500 mg/kg,
orl-hmn
TCLo:150 ppm
TFX:IRR, ihl-hmn
USOS air: TWA
25 ppm or 90
mg/m3
311 Propane, 2-nitro
000079469 LDLo: 500
(WNY) rat
LDLo: 500
rbt
TDLo:20ppm
TFX:GIT, ihl-hmn
Gastrointestinal
disturbances
& injury to kidneys
& liver. Large
doses produce
methemoglobinemia
& cyanosis
LCLo:1513ppm/
5H, ihl-rat
LDLo:75 mg/kg,
ipr-mus
LCLo:714ppm/
5H, ihl-cat
LCLo:2381 ppm/
5H, ihl-rbt
USOS air: TWA
25 ppm or 90
mg/m3
p-Nitrochlorobenzene,
see 104DP
216
-------
Process
(Sources
of Compound)
See above item
Total
Process Waste Production
No. Associated Wastes Treatment 10^ kg/year Uses
See See above item — — See above item
above
item
References
2)647
3)864
Ditto
Ditto
Ditto
87% manufacture ethyl 2)647
& methyl parathions 13)
(insecticide); 13% other
including synthetic dyes,
n-acety l-p-am i no-phenol
& leather treatments;
production of phenetidines;
indicator; fungicide; photo-
chemicals
Ditto
2)647
3)864
See Nitroethane 237
Solvent in the coating 1 )578
industry; printing inks; 2)964
propellents; fuels; 3)972
pesticides 7)13-879
Ditto
Ditto
— Ditto
2)756
3)865
5)562
Ditto
Ditto
Ditto
Ditto
(Continued)
217
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
312G Nitrotoluene
DP (3 isomers)
CH3C6H4N02
(WNR X)
312 Toluene, o-nitro
000088722
(WNR B)
891 rat
2462 mus
USDS air: TWA
5 ppm (skn) or
30 mg/m3 (skn)
313 Toluene, p-nitro
000099990
(WNR D)
2144 rat
1231 mus
LD50:940 mg/kg,
ipr-rat
USDS air: TWA
5 ppm (skn) or
30 mg/m3 (skn)
314 Toluene, m-nitro
000099081
(WNR C)
1072 rat
330 mus
2400 rbt
3600 gpg
USDS air: TWA
5 ppm (skn) or
30 mg/m3 (skn)
315 Nonene
C7Hi4'CH:CH2
(C9H18)
027215958
(8U1)
316 Nonylphenol
DP (Phenol, n-nonyl)
(C15H240)
025154523
(QR X9)
1620 rat
LD50:2140 mg/kg,
skn-rbt
317
DP
Octylphenol
(Phenol, n-octyl)
C6H4(C8H17)OH
(C14H220)
027193288
(QR X8)
LDLo: 25 mg/kg,
ipr-mus
318 Oxo alcohols
218
-------
Process
(Sources Process
of Compound) No.
Nitration 338
(Toluene, nitric
acid, sulfuric
acid, sodium
hydroxide)
Associated Wastes
Water: Soluble by-
products, alkali or
spent acid
Solids: Heavy tar
still bottoms
Total
Waste Production
Treatment 10^ kg/year
Still bottoms —
disposed
(40 kg/1 000
kg)
Uses
Organic synthesis; for
production of toluidine.
tolidine, fuchsin, &
various synthetic dyes;
explosives
References
1)782
2)915
3)869
7)13-849
Ditto
Ditto
Ditto
2)915
3)869
5)526
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
See dodecene 264
Alkylation 311
(Phenol, nonene.
BF3 catalyst)
Alkylation 312
(Phenol, diisobuty-
lene, H2S04
catalyst)
Reduction or 188
dimerization
(Aldehydes,
phosphine pro-
moted Co
carbonyl catalyst.
hydrogen, Ni
— — —
Water: phenol, nonyl- Product wash 49/1973
phenol, boron salts unit
Emission factors:
phenol - 2.0
nonylphenol - 1.0
Water: phenol, Product wash —
H2S04, octylphenol unit
Emission factors:
phenol - 1.0
propylene - 1.0
Air: Hydrocarbons — —
Water:
Flow- 1.59m3/454kg
COD- 1.21 kg/m3
1 .93 kg/454 kg
BOD5 - 0.9 kg/m3
- 1 .43 kg/454 kg
Organic synthesis; wetting
agent; lube oil additive;
polymer gasoline
Manufacturing; 70% non-
ionic surfactant (nonbio-
degradable), 15% plastic
& rubber antioxidants,
10% lube oil additives,
5% miscellaneous; petro-
leum demulsif iers, fungi-
cides; bactericides; dyes;
drugs; adhesives; rubber
chemicals; phenolic resins
& plasticizers ore flotation
Nonionic surfactants;
plasticizers; antioxidants;
fuel oil stabilizer; inter-
mediate for resins, fungi-
cides, bactericides, dye-
stuffs, adhesives; rubber
chemicals
1)640
2)596
1)728
2)648
3)871
7)1-908
9)23
12)
13)42
1)730
2)648
3)876
12)
1)472
(Continued)
219
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
318 (Continued)
319 Oxo aldehydes
320 Paraldehyde
(s-Trioxane, 2,4,6-
trimethyl)
OCH(CH3)OCH(CH3)
OCHCH3
(C6H1203)
000123637
(T60 CO
EOTJ
8DF)
1530 rat TDLo: 14 mg/kg,
3304 rat TFX:PSY,orl-hmn
TDLo: 14 mg/kg,
TFX:PSY, ivn-hmn
TDLo:71 mg/kg,
TFX:PSY, ims-hmn
TDLo:14 mg/kg,
TFX:PSY, rec/hmn
Hypnotic & analgeric
properties. Habit
forming
TDLo:12gm/kg/
W,TFX:NEO,
skn-mus
321 PEG chloride
(Polyethylene glycol
chloride)
(Acetaldehyde, chloro-
dimethylacetal)
000097972 1070 rat
(C4HgCIO2)
LD50:3180 mg/kg,
skn-rbt
322
Pentaerythritol
C(CH2OH)4
(C5H1204)
000115775
(Q1 4X)
25,500 mus
11,300 gpg
Low toxicity
10mg/m3
323
Pentane
CH3(CH2)3CH3
-------
Process
(Sources
of Compound)
Process
No. Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses References
TOC - 0.549 kg/m3
0.87 kg/454 kg
Oxo Process,
Hydroformylation
(Synthesis gas,
olefin, Co car-
bonyl catalyst)
187 Air: olefin, synthesis
gas
1)470
Polymerization
(Acetaldehyde,
sulfuric acid
catalyst)
93 Water: acetaldehyde,
sulfuric acid
Emission factors:
acetaldehyde- 10.0
Substitute for acetalde-
hyde; rubber accelerators;
rubber antioxidants;
synthetic organic chemi-
cals; dyestuff inter-
mediate; medicine; solvent
for fats, oils, waxes, gums,
resins, leather; solvent
mixtures for cellulose
derivatives
1)255
2)933
3)885
12)
Polymerization,
Chlorination
Ethylene oxide,
ethylene
chlorohydrin
2)736
See formic acid
94 Emission factors:
Hydrocarbons - 30.0
46.8/1973 Manufacturing: 70% alkyd 1)257
56.7/1974 resins, 13% rosin & tall oil 2)619
45.2/1975 esters, 7% jet engine lubri- 3)889
55/1978 cants, 3.5% PETN explosi- 6)645
ves; special varnishes; 7)1-592
Pharmaceuticals; plasti- 11)37
cizers; insecticides; paint 12)
swelling agents; printing
inks; floor coverings;
adhesives; dietetic foods;
surface-active agents; poly-
urethane foams; molded
pipes; gears; electrical
insulators
See Butane
Automotive, aviation,
form fuels; manufacture
of ethylene & other
olefins, solvent,blowing
agent for foams; synthetic
rubber
2)619
3)890
7)14-714
(Continued!
221
-------
TABLE A-1. (Continued)
Item
No.
324G
325
326
327
Compound
Name and
Formula
Pentylenes
(Amylene)
(CsH-io)
1-Pentene
(a-n-Amylene)
CH3(CH2)2CH:CH2
(C5H10)
2-Pentene
(a-n-Amylene)
CH3CH:CHCH2CH3
(C5H10>
Perchloroethylene
(Ethylene, tetra-
chloro)
CCI2CCI2
Chem. Abstr.
Registry No.
(WLN)
025377724
000109671
(4U1)
000109682
(3U2)
000127184
(GYGUYGG)
Oral Toxicity,
LD,.n, mg/kg
3U
Unknown
8850 mus
LDI_o:4000
dog
LDLo:4000
cat
LDLo:5000
rbt
Toxicology TLV Carcinogen
—
Narcotic in high — —
concen. Simple
asphyxiant
Unknown. Probably — —
narcotic in high
concen
LDLo:500 mg/kg, USOS air: TWA —
orl-hmn 100 ppm; or
TCLo:200ppm, 670 mg/m3
TFX:SYS, ihl-hmn C: 200 ppm
TCUo:280 ppm/2H PK: 300 ppm/5M/
TFX:EYE, ihl-man 3H
TCLo:600ppm/10M
TFX:CNS, ihl-man
Acute effects are to
CNS. Also causes
dermatitic, irr to
GI tract
LCLo:4000ppm/4H,
ihl-rat
LDLo:85mg/kg,
ivn-dog
LDLo:2200mg/kg,
scu-rbt
Ditto
Ditto Ditto
Ditto
Ditto
Ditto
Ditto
Ditto Ditto
Ditto Ditto
Ditto
Ditto
Ditto
Ditto
328
Perchloromethyl
mercaptan
(Methanethiol,
trichloro)
CISCCI3
(CCI4S)
000075707 83 rat
(SHXGGG)
TCLo:45 ppm
TFX:EYE, ihl-hmn
LCLo:483 ppm/
10M, ihl-hmn
Highly toxic
LCLo:58ppm/
10M, ihl-mus
LCLo:58 ppm/
15M, ihl-cat
USOS air: TWA
0.8 mg/m3 or
0.1 ppm
TCLo:15mg/m3/
68WITFX:CAR,
ihl-rat
222
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
See Amyl alcohol 244
1)592
Organic synthesis; blend- 1)592
ing agent for high octane 3)375
motor fuel
Polymerization inhibitor; 1)592
organic synthesis 3)891
Chlorination of
mixed hydrocar-
bons
(Methane, ethane,
ethylene, LPG,
propane, ethylene
dichloride, vinyl
chloride process
wastes)
235 Air: HCI and mixed
chloro-hydrocarbons
Heavy distilla- 321/1973 75% dry cleaning solvent; 1)573
tion ends 334/1974 7% vapor-degreasing sol- 2)422
incinerated 306/1975 vent; 8% intermediate, 3)892
328/1978 especially fluorocarbons; 5)563
drying agent for metals & 11)37
certain other solids; ver- 13)43
mifuge; heat-transfer
medium; rubber solutions;
paint removers; printing
ink; Pharmaceuticals
See carbon
tetrachloride
234
Ditto
Ditto
1)571
Ditto
See trichloro-
ethylene
140
180
Ditto
Ditto
Ditto
Ditto
1)364
1)452
Chlorination
(Carbon disulf ide,
chlorine, iodine
catalyst)
165 Air: traces reactants
sulfur
1)423
2)541
3)892
5)562
(Continued)
223
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
329G
DP
o- and p-Phenetidine
(ZR X02)
High toxicity orl,
ihl, skn, eye, mucous
membrane. See
Aniline.
329 o-Phenetidine
DP (2-Aminophenetole)
000094702
(ZR B02)
Carcingenic in
man
330 p-Phenetidine
DP (4-Aminophenetole)
000156434
(ZR D02)
LD50:692 mg/kg,
unk-mus
Ditto
331 Phenol
DP CgHgOH
(C6H60)
000108952
(OR)
TDLo:14TFX: LDLo:140 mg/kg, USDS air: TWA TDLo:4000mg/
GIT orl-hmn
530 rat
414 rat
300 mus
LDLo:420
rbt
orl-hmn
Effects CNS in
acute poisoning.
Death can result
from abs through
skn. Where death
is delayed damage
to the kidneys,
liver, pancreas,
spleen, & edema
of lungs may occur
LD50:669 mg/kg,
skn-rat
LD50:250 mg/kg,
ipr-rat
LDLo:650 mg/kg,
scu-rat
LD50:344 mg/kg,
scu-mus
LDLo:80 mg/kg,
scu-cat
LD 1.0:620 mg/kg,
ipr-rbt
LDLo: 180 mg/kg,
ivn-rbt
5 ppm (skn) or
19mg/m3
(skn)
kg/20WITFX:CAR
skn-mus
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
224
-------
Process
(Sources Process
of Compound) No.
Ethylation & 308
reduction
(o,p-Nitrophenol,
ethyl sulfate or
ethyl chloride,
sodium hydroxide,
hydrochloric acid,
iron filings,
water)
Total
Waste Production
Associated Wastes Treatment 1 0^ kg/year
Water: NaCI, ethyl — —
chloride, ethyl alcohol.
nitrophenol, phenti-
dene isomers, by-
products
Air: ethyl chloride.
ethyl alcohol, HCI
Uses References
1)724
2)638
3)897
7)2-422
Ditto
Ditto Ditto
Manufacture of dyes;
laboratory reagent
3)1007
Ditto
Ditto Ditto
Dyestuffs intermediate; 2)638
Pharmaceuticals; medi- 3)1008
cine; synthetic sweetner;
rubber antioxidant
See Acetone
37
&
295
1019/1973 Manufacture: 49% 2)638
1045/1974 phenolic resins, 14% 3)897
783/1975 bisphenol-A, 14% capro- 4)810
1239/1978 lactam, 4% methylated 5)562
phenol, 3% plasticizers, 7) 15-158
3% adipic acid, 2% sali- 11)37
cyclic acid, 2% nonyl- 13)43
phenol, 1%dodecylphenol,6)647
3% other alkyl phenols,
1% 2,4-D, 1% pentachloro-
phenol, 2% chlorophenols,
1% petroleum refining,
miscellaneous
See mixed cresols
and o-cresol
78
— Ditto
Ditto
(Continued)
225
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50.mg/kg
Toxicology
TLV
Carcinogen
See above item
See above
item
See above
item
See above item
See above item See above item
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Phenols, higher
methylated
332 Phenolsulfonic acid
DP (Benzenesulfonic
acid, p-hydroxy)
C6H5S03H
(C6H603S)
(WSQR XQ)
003724138
(WSQR DQ)
— Less toxic than phenol
333 N-Phenyl anthranilic
DP acid
(Anthranilic acid, N-
phenyl)
C6H5NH-C6H4-C02H
(CTsHnNC-2)
000091407
(QVR BMR)
334G Phenylenediamines
DP (3 isomers)
C6H4(NH2)2
(C6H8N2)
226
-------
Process
(Sources Process
of Compound) No.
Oxidation 326
(Benzoic acid, air,
Mn promoted
cupric benzoate
catalyst)
Associated Wastes
Water: kg/Mg
Acetone (1.8), Mn
benzoate (5), Cu
benzoate (2.1)
Solids: kg/Mg
Phenyl benzoate (1.5),
tars (102)
Waste
Treatment
Azeotrope
separator.
centrifuge
Total
Production
1 06 kg/year Uses
See item See item above
above
References
1)762
Substitution,
Hydrolysis
(Chlorobenzene,
sodium hydroxide,
diphenoloxide
solvent)
Water: Chlorobenzene,
dichlorobenzene,
chlorotoluene, phenol,
benzene, diphyl ether
Ditto
Ditto
1)63
See m-cresol
82
Sulfonation
(Phenol,
sulfuric acid)
314 Water: sodium hydroxide —
Water analysis; laboratory
reagent; electroplated tin
coatings baths; manu-
facture of intermediates
& dyes; Pharmaceuticals;
nitrate analysis; drilling
fluids; bleaching agent;
plasticizer for concrete;
printing; color inhibitor;
ion-exchange resins; •>"
tanning agent
1)733
3)898
7)15-212
29.1/1971 Azo dye intermediate; 3)1013
photo developing agent; 5)562
fur dyes; photochemical
measurements; intermediate
in manufacture of antioxi-
dants & accelerators for
rubber; detection of nitrous
acid; textile developing
agent; organic synthesis;
laboratory reagent
(Continued)
227
-------
TABLE A-2. (Continued)
Item
No.
334
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LD5Q, mg/kg
m-Phenylenediamine 000108452 LDLo:80
(ZR CZ) rat
LDLo:300
cat
LDLo:300
rbt
Toxicology TLV Carcinogen
High orl, scu, ivn — —
toxicity
LDLo:30or80
mg/kg, scu-rat.
see 2) & 3)
LDLo: 17 mg/kg,
ivn-dog
LDLo:200 mg/kg.
scu-rbt
335 o-Phenylendiamine
000095545
(ZR BZ)
LDLo:50 mg/kg,
orl-hmn
Moderate toxicity
LDLo:600 mg/kg,
scu-rat
LDLo:600 mg/kg,
scu-mus
336 p-Phenylenediamine
000106503
(ZR DZ)
LDLo: 100
rat
LDLo: 100
cat
LDLo:250
rbt
LDLo:50 mg/kg,
orl-hmn
Skn irr. High
toxicity orl, scu,
ivn with death
from liver damage.
LDLo:50 mg/kg,
ipr-rat
LDLo: 170 mg/kg,
scu-rat
LDLo:100 mg/kg,
scu-dog
LDLo:17 mg/kg,
ivn-dog
LDLo:200 mg/kg,
scu-rbt
USDS air: TWA
0.1 mg/m3 (skn)
337
DP
Phosgene
COCI2
(CCI2O)
000075445
(GVG)
LC50:3200 mg/m3, USDS air: TWA
0.1 ppm or 0.4
mg/m3
ihl-hmn
TDLo:25 ppm/30M
TFX:IRR, ihl-hmn
Little warning
properties. Where
exposure is severe
pulmonary edema
occurs. Death
may occur within
36 hours after
exposure.
LDLo:50ppm/30M,
ihl-rat
LC50: 110ppm/30M,
ihl-mus
LCLo:79 ppm/30M,
ihl-dog
0.05 ppm or
0.2 mg/m3
(proposed
1974)
228
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Reduction
(m-Dinitrobenzene,
iron, HCI)
27 Water: Iron, iron sul-
fides, ammonia,
ammonium
polysulfides
See item
above
See item above
1)102
2)657
3)901
Substitution,
Amination
(o-Dichloro-
benzene.
Ammonia, Cu
catalyst)
28 Air: NH3
Water: Hydrochloric
acid, copper
chlorides
Ditto
Ditto
1)103
2)657
3)902
Reduction
(p-Nitroaniline,
hydrochloric
acid, iron
powder)
30
Water: Same as 27
Ditto
Ditto
1)107
2)657
3)902
5)562
Chlorination
(Carbon monoxide,
chlorine, NaOH,
activated carbon
catalyst)
189 Water: spent Scrubber 330.6/1973 Manufacture: 62% toluene 1 )475
caustic 394.3/1974 diisocyanates (TDD, 23% 2)660
other isocyanates (MDI, 3)908
PAP I, etc.), 6% poly- 5)562
carbonates, 9% misc- 6)648
aneous (pesticides, car- 7)15-680
bonates, & specialties); 9)205
dye manufacture; aerial 12)
warfare; ore flotation; 13)43
perfumes
(Continued)
229
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD, mg/kg
Toxicology
TLV
Carcinogen
— Isophthalic acids,
see 256
— Terephthalic acids,
see 374
LC50:1087ppm/
1M, ihl-mky
LC50:1482ppm/
1M, ihl-cat
LC50:141 ppm/
30M, ihl-gpg
338 Phthalic anhydride
DP C6H4(CO)2O
(C8H403)
000085449
(T56
BVOVJ)
4020 rat
LDLo:100
gpg
Moderate orl
toxicity
USOS air: TWA
2 ppm or 12
mg/rr>3
TLV air: 1 ppm
Ditto
Ditto
Ditto
Ditto
Ditto
339
DP
Phthalimide
C6H4(CO)2NH
(C8H5N02)
000085416 Unknown
(T56
BVMMVJ)
Unknown
340
DP
Phthalonitrile
C6H4(CN)2
(C8H4N2)
000091156
(NCR BCN)
1860 rat
65 mus
LDLo:50mg/kg,
orl-hmn
LD50:62 mg/kg,
ipr-rat
LD50:35 mg/kg,
ipr-mus
LD50:46 mg/kg,
scu-mus
TDLo: 1710 mg/kg/
145 Dl
TFX:CAR,scu-rat
TDLo:7gm/kg/
443 Dl
TFX:CAR, scu-mus
TDLo:101 gm/kg/
461 Dl
TFX:NEO, orl-rat
TDLo:21 gm/kg/
457 Dl
TFX:NEO,orl-mus
230
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Oxidation
(Naphthalene, air,
catalyst)
220 Water: kg/Mg Spray scrubber 465/1973 Manufacture: 50% plasti- 1)539
maleic anhydride 444/1974 cizers, 19% alkyd resins, 2)703
(42.7), phthalic 322/1975 24% polyesters; synthesis 3)914
amhydride (78.8), 451/1978 of phenolphthalein & 5)562
other (74.7) other phthaleins, many 6)648
other dyes; chlorinated 7)15-455
products; pharmaceutical 1 1 )37
intermediate; insecticides 13)44
Oxidation
(o-Xylene, air,
catalyst)
360
Water: 8-26 ppm
formaldehyde,
1.7-2.5% maleic
acid, COD+BOD
approximately
2-6 kg/Mg
Ditto
1)830
Ammonolysis,
Substitution
(Phthalic
anhydride,
ammonia)
225 Air or Water: Ammonia
ammonia, phthalic absorber
anhydride
Synthesis indigo, via 1 )651
anthranilic acid; fungicide; 2)704
organic synthesis; labora- 3)914
tory reagent
Vapor ammono-
lysis& dehydra-
tion
(Phthalic
anhydride,
ammonia)
222 Air: ammonia,
phthalic anhydride,
phthalonitril,
phthalamide,
phthalimide
Intermediate in organic
synthesis, especially pig-
ments & dyes; base
material for high tem-
perature lubricants &
coatings; insecticides
1)544
2)705
3)568
(Continued)
231
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgQ, mg/kg Toxicology
TLV Carcinogen
341 <3-Picoline
(Pyridine, 3-methyl)
CH3C5H4N
(C6H7N)
(T6NJ B)
Unknown
342 Piperazine
NHCH2CH2NHCH2
CH2
(C4H10N2)
000110850 3800 rat
(T6M DM
DMTJ)
LDLo:5000 mg/kg,
orl-hmn
Excessive abs can
cause urticaria,
vomiting, diarrhea,
blurred vision,
weakness
LD50:1100mg/kg
scu-mus
343 Polybutenes
(/*3UV
344 Polyethylene glycol
H(OCH2CH2)nOH
H(C2H40)nOH
02322683
(/1*02*1/)
26,000 rat
LDLo:5000 mg/kg,
orl-hmn
TDLo:420gm/kg/
Y
TFX:CAR, ivg-mus
(PEG 400)
345 Polyethylene glycol
chloride
1070 rat
LD50:3180 mg/kg,
skn-rbt
H(C2H40)nCI
346 Polypropylene glycol
HO(C3H6O)nH
(C3H802)
025322694
(/*OY1*/)
419 rat
2150 rat
LDLo:500 mg/kg,
orl-hmn
232
-------
Process
(Sources Process
of Compound) No.
Chichibabin 100
synthesis
(Acetaldehyde,
ammonia,
formaldehyde,
methanol, silica-
alumina catalyst)
Ammonolysis of 154
Process 152
Amines
(Ethanolamines,
excess ammonia.
Ni, Cu, Cr
catalyst)
Polymerization 239
(Butane /buty tones
AICI3)
See Diethylene 155
glycol
Waste
Associated Wastes Treatment
Air: formaldehyde, —
ammonia, acetalde-
hyde, amine
byproducts
Water: ammonia, HCI, —
ammonium chloride,
alcohol, ethylene
dichloride, piperazine.
sodium hydroxide
Air: ammonia, others
Air: C4 hydrocarbons, —
dimers, trimers, etc.,
alcohols, ethers.
alkylhalides
Total
Production
106 kg/year Uses
— Vitamins
— Corrosion inhibitor;
anthelmintic; insecticide;
accelerator for curing
polychloroprene & epoxy
resins; textile water
proofing
104.4/1967 Hot-melt adhesives; seal-
84/1974 ing tapes; special sealants;
cable insulation; polymer
modifier; viscosity index
improvers; lube oil
additive
25.8/1973 Chemical intermediate
44.0/1974 (lower molecular weight
varieties); plasticizers;
softeners & humectants;
lubricants; bases for
cosmetics & Pharmaceuti-
cals; solvent; binders;
metal & rubber processing
permissible additives to
foods & animal feed;
References
1)270
3)915
13)44
1)390
2)708
3)916
7)15-644
1)582
12)
1)392
2)736
3)921
7)10-657
9)204
12)
laboratory reagent; insecti-
__
__
cides herbicides
— Solvent for cleaning, ex-
tracting, & dewaxing
2)736
3)921
Addition
(Propylene oxide,
propylene glycol,
base catalyst)
288 Water: reactants and
products, spent
catalyst
Dehydrator 38.8/1973 Hydraulic fluids; rubber 1)686
lubricants; antifoam agent; 2)737
intermediate in urethane 3)922
foams, adhesives, coatings, 9)204
elastomers; plasticizers;
paint formulations; labora-
tory reagent
(Continued)
233
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
347
Propane
CH3CH2CH3
(C3H8)
000074986
(3H)
— Asphyxiant; at high
concen has a CNS
effect
USDS air: TWA
1 000 ppm
— Propene, 3-chloro,
see 20
— Propene, 3-hydroxy,
see 19
— 2-Propanol, see 259
348 Propionaldehyde
CH3CH2CHO
(C3H4O)
(VH2)
000123386 1400 rat
LDLo:800
rat
LDLo:800
mus
Moderate toxicity
LCLo: 8000 ppm/
4H, ihl-rat
LD50:820 mg/kg,
scu-rat
LD50:680 mg/kg,
scu-mus
LDLo: 3400 mg/kg,
skn-rbt
Ditto
Ditto
Ditto
Ditto
349 Propionic acid
CH3CH2COOH
(C3H602)
000079094 151 Oral
1370 mus
1900 rbg
(QV2)
Low toxicity based
on animal studies
LD50:625 mg/kg,
ivn-mus
LD50:500 mg/kg,
skn-rbt
Ditto
Ditto
Ditto
234
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
See Butane
21,802/1971
Organic synthesis; house-
hold & industrial fuel;
manufacture of ethylene,
extractant; solvent; re-
frigerant; gas enrichener;
aerosol propellent; mix-
ture for bubble chambers;
general purpose food
additives
2)743
3)938
7)16-547
Oxidation,
Dehydrogenation
(n-Propyl alcohol,
iron oxide or
copper catalysts)
229
Air: hydrogen, n-
propyl alcohol,
propionaldehyde
Manufacturing of poly- 1 )564
vinyl acetals & other 2)766
plastics; synthesis of 3)941
rubber chemicals; dis- 4)873
infectant; medicine; 7)16-551
preservative; agriculture
See Allyl alcohol
251B
See acetic acid
227
Emission factors:
acetone -10.0,
ethylene - 2.0,
CO - 2.0
27.4/1973 Cellulose propionates, 1)560
39.5/1974 other pripionates (e.g., Ca 2)768
Na) some of which are 3)940
used as mold inhibitor in 6)367
bread & fungicides in 9)202
general; herbicides; plasti- 12)
cizers & Pharmaceuticals; 13)44
emulsifying agents; solu-
tions for electroplating
nickel; perfume esters;
artifical fruit flavors; sol-
vent mixtures for cellulose
derivatives
Carbonylation 126 — — Ditto Ditto
(Ethylene, carbon
monoxide, water,
NiC03/HB03
catalyst)
1)330
7)16-556
(Continued)
235
-------
TABLE A-1. (Continued)
Item
No.
350
351
Compound
Name and
Formula
n-Propyl alcohol
(C3H80)
n-Propylamine
(C3HgN)
Chem. Abstr.
Registry No.
(WLN)
000071238
(Q3)
000107108
(Z3)
Oral Toxicity,
LD5Q, mg/kg
LDLo:5700
wmn
1870 rat
LDLo:140
mus
LDLo:3500
rbt
LDLo:570
rat
Toxicology TLV Carcinogen
LDLo:500 mg/kg, USOS air: TWA
orl-hmn 200 ppm or
LDLo:5700 mg/kg, 500 mg/m3
orl-wmn
LDLo:4000ppm/
4H, ihl-rat
LD50:3230 mg/kg.
scu-mus
LDLo:5 mg/kg,
scu-man
Strong irr, skn USOS — —
sensitizer
LC50:2310ppm/
4H, ihl-rat
LD50: 560 mg/kg,
skn-rbt
Ditto
Ditto
Ditto
Ditto
352
n-Propyl chloride
CH3CH2CH2CI
(C3H7CI)
000540545
(G3)
Irr to mucous
mem; narcotic
in high concen
353
Propylene
(Propene)
-------
Process
(Sources Process
of Compound) No.
See butyl alcohol 227
Associated Wastes
Emission factors:
propyl alcohol - 3.0,
hydrocarbons - 2.0
Total
Waste Production
Treatment 1 06 kg/year
42.1/1973
43.8/1974
Uses
Printing ink solvent; nail
polish; lacquer; wood
dyes; solvent plasticizer;
metal degreaser; pesti-
chemical intermediate
References
1)560
2)779
3)940
4)875
5)562
7)16-562
9)203
12)
Ammonolysis
(n-Propyl alcohol,
ammonia, activated
alumina catalyst)
228 Air or Water:
ammonia, n-propyl
alcohol, propyl-
amines
Stripper, 0.20/1973 Intermediate; laboratory 1)562
separator 1.6/1974 reagent; rubber chemical; 2)779
dyestuffs; textile & leather 3)941
finishing resins; pharma- 7)2-123
ceuticals; petroleum addi- 9)201
lives; agricultural chemi- 12)
cals; corrosion inhibitor
Amination
(n-Propyl chloride,
ammonia)
231
Air or Water:
ammonia, propyl
chloride, propyl-
amines
Ditto
Ditto
1)566
Substitution,
chlorination
(n-Propyl alcohol,
hydrochloric acid,
ZnC>2 catalyst)
230
Water: zinc salts,
propyl chloride,
tars
Solvent; intermediate
propylamine
1)565
2)743
3)942
4493/1973 Manufacture: 46-50% 2)764
4761/1974 chemicals & 50-54% non- 3)942
3454/1975 chemical; chemical: 11% 6)650
6534/1978 polypropylene, 7.7% 7)16-591
acrylonitrile, 6.7% iso- 9)37
propyl alcohol, 6.2% 13)44
propylene oxide, 5.3%
cumene, 4% oxo chemicals,
miscellaneous; nonchemi-
cal: 34-37% gasoline
alkylate, 6% polygas
Addition, Hydro-
chlorination
(Propylene,
chlorine, water)
285 Air: may contain bis —
(chloroisopropyl
ether), ethylene.
propylene, butane.
HCI, C\2
Water: caustic soda.
sodium chloride
— Organic synthesis (intro-
ducing hydroxypropyl
group); polyurethane
foams; cosmetics; drugs
& food
1)679
2)758
3)942
7)5-310
(Continued)
237
-------
TABLE A-1. (Continued)
Compound
Item Name and
Chem. Abstr.
Registry No. Oral Toxicity,
No.
Formula
See item above
(WLN)
See item
above
LDgo, mg/kg
See item above
Toxicology
See item above
TLV Carcinogen
—
355 Propylenedichloride
(Propane, 1,2-dichloro)
CH2CICHCICH3
(C3H6CI2)
000078875
(GY1G)
1900 rat
860 mus
LDLo:5000
dog
LDLo:50 mg/kg,
orl-hmn
Dermatitis. Liver,
kidney & minor
heart damage in
animals exposed
to high concen
LCLo:2000ppm/
4H, ihl-rat
USDS air: TWA
75 ppm or
350 mg/m3
Propylene glycol,
see 293
356 Propylene oxide
(Propane, 1,2-epoxy)
OCH2CHCH3
(C3H60)
000075569
(T30TJ B)
930 rat LCLo:400 ppm/4H,
690 gpg ihl-rat
LC50:1740 ppm/
4H, ihl-mus
LCLo:2005 ppm/
4H, ihl-dog
LD50:1500 mg/kg,
skn-rbt
USOS air: TWA
100 ppm or
240 mg/m3
TDLo:1500mg/
kg/46WI
TFXrNEO, scu-rat
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
357
DP
Pyridine
NCHCHCHCHCH
(C5H5N)
000110861
(T6NJ)
891 rat
LDLo:4000
gpg
LDLo:500 mg/kg,
orl-hmn
Mild skn irr; CNS
depressant
LCLo: 4000 ppm/
4H, ihl-rat
LD50:1000 mg/kg,
scu-rat
LDLo: 1200 mg/kg,
ipr-mus
USOS air: TWA
5 ppm or 15
mg/m3
238
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Hydration,
Hydrolysis
(Allyl chloride,
sulfuric acid,
water)
316 Water: sulfuric acid,
allyl chloride, propylene
chlorohydrin
See item above
1)736
See Propylene
chlorohydrin,
Process 285
322
Intermediate for per- 1 )748
chloroethylene & carbon 2)759
tetrachloride; lead 3)566
scavenger for antiknock 4)876
fluids; solvent for fats, 5)562
oils, waxes, gums, &
resins; solvent mixtures
for cellulose esters &
ethers; scouring compounds;
spotting agent; metal de-
greasing agent; soil fumi-
gant for nematodes
Elimination, 286 Air: kg/Mg
Hydrolysis ethane (8.5), butane
(Propylene (8.5), propylene (8.5),
chlorohydrin, C\2 d.O), HCI (1.0),
calcium propylene oxide (4.1),
hydroxide) Water: calcium
chloride, calcium
hydroxide, propylene
glycol
Emission factors:
ethane, propane &
propylene - 17.0,
propylene oxide - 8.2
Caustic 797/1973 Manufacture: 56% poly- 1)681
absorber 798/1974 propylene glycols & poly- 2)755
692/1975 ester glycols for poly- 3)944
929/1978 urethanes, 29% propylene 5)562
glycol, 5% dipropylene 6)651
glycol, 5% surf acts, 5% 7)16-606
glycol ethers & misc.; 11)37
isopropanol amines; 12)
synthetic elastomer 13)45
(homopolymer); food
additive; lubes
Epoxidation,
Peroxidation
(Propylene, iso-
butane, air, Mo
catalyst)
See (3-Picolene
320 Air: isobutane, butane,
propylene, propylene
oxide, ethylene oxide,
acetaldehyde (quanti-
ties given)
Ditto 1)744
3.4/1968 Synthesis of piperidine, 1)270
vitamins & drugs; solvent; 2)796
waterproofing; rubber 3)947
chemical; denaturant for 5)562
alcohol & antifreeze 7)16-801
mixtures; dyeing assistant
in textiles; bactericides;
fumgicides; herbicides
(Continued)
239
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
357 (Continued)
LD50:1121 mg/kg,
skn-rbt
LDLo:870 mg/kg,
ipr-gpg
— Quinone, see 48
358 Resorcinol
DP C6H9(OH)2
(C6H602)
000108463
(QR CQ)
301 rat LDLo:29 mg/kg,
orl-hmn
Skn irr; systemic
blood & nerve
poison; in suitable
solvent it can be
absorbed through
skn & cause local
hyperemia, itching,
dermatitis, edema,
& corrosion associated
with enlargement of
lymph glands,
methemoglobinemia,
cyanosis, convul-
sions, tachycardia,
syspnea & death
LDLo:340 mg/kg,
scu-mus
LDLo:270 mg/kg,
par-frg
TDLo:4800 mg/kg/
12WI
TFX:NEO,skn-mus
359
DP
Resorcylic acid
(Benzole acid, 2,4-
dihydroxy-)
027138574
(QVR BQ
DQ)
(C7H604)
360 Salicylic acid
DP HOCeH4COOH
000069727
(QVR BQ)
891 rat
LDLo:1300
rbt
LDLo:50 mg/kg,
orl-hmn
Nausea, dizziness,
headache, confusion,
sweating, rapid
pulse & breathing,
skn eruption;
symptoms disappear
when material is
removed or dis
discontinued
LDLo:520 mg/kg,
scu-mus
240
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Substitution,
Fusion
(m-Benzenedisul-
fonic acid, sodium
sulfite, sodium
& calcium car-
bonate, sodium
hydroxide, hydro-
chloric acid,
ether)
23 Air: SOX
Water: Sludge
Emission factors:
hydrocarbons - 2.0
resorcinol -1.0
11.8/1970 Manufacture: 43% tire 1)93
& rubber products, 13% 2)842
resorcinol-formaldehyde 3)955
resins; dyes; pharmaceuti- 7)11-478
cals; cross-linking agent 12)
for neoprene; rubber 13)45
tackifier; adhesives for
wood venteers & rubber-to -
textile composites; medi-
cine; manufacture of
styphnic acid; analytical
agent; explosion detonators;
cosmetics; skn ointments;
tanning agent; extraction
of lubricating oil, ion
exchange
Dyestuff & pharmaceuti-
cal intermediate chemical
intermediate in synthesis
of fine organic chemicals;
light stabilizers; resins
Carboxylation
(Sodium phenate,
CO2, hydrochloric
acid or sulfuric
acid)
303A
Water: NaCLor
sodium sulfate,
hydrochloric
acid or sulfuric
acid, phenol,
salicylic acid
Emission factors:
phenol -1.0
H2SO4-0.1
6.2/1969 53% manufacture aspirin, 1)714
18.9/1973 other medicinals; preserva- 2)848
19.9/1974 tive; dyes; perfumes; pre- 3)962
vulcanization inhibitor; 7)17-726
organic intermediate; 9)24
fungicide; food additive 12)
for human consumption 13)45
(Continued)
241
-------
TABLE A-1. (Continued)
Item
No.
361
DP
Compound
Name and
Formula
Sodium acetate
(Acetic acid.
sodium salt)
NaC2H3O2
(C2H3NaO2)
Chem. Abstr.
Registry No.
(WLN)
000127093
(OV1 &-NA-)
Oral Toxicity,
LD5Q, mg/kg
3530 rat
4960 mus
Toxicology TLV
LD50:8000 mg/kg.
scu-mus
LD50:335 mg/kg,
ivn-mus
LDLo:3000 mg/kg.
ivn-dog
Carcinogen
362
Sodium benzoate
(Benzoic acid,
sodium salt)
000532321
(OVR &-NA-)
4100 rat
LDLo:2000
rbt
Large doses by
mouth cause
nausea & vomit-
ing. Small doses
have no effect
LDLo: 2000 mg/kg,
scu-rbt
LDLo:1400 mg/kg,
ipr-gpg
LDLo: 1000 mg/kg,
scu-frg
363 Sodium carboxy-
methyl cellulose
(Cellulose, carboxy-
methyl ether, sodium
salt)
009004426 27,000 rat
LD50:46,000
orl-gpg
TDLo:8600mg/
kg/19WI TFX:
NEO,scu-rat
364 Sodium chloroacetate
(Acetic acid, chloro-
sodium salt)
CICH2COONa
(C2H2CINaO2)
003926623
(QV1G&
-NA-)
76 rat
165 mus
SOgpg
LD50:109 mg/kg,
ivn-mus
365
DP
Sodium formate
(Formic acid,
sodium salt)
HCOONa
(CHNaO2)
000141537
VHQ
&-NA-)
11,200 mus
LDLo: 4000
dog
LD50:807 mg/kg,
ivn-mus
LDLo:3000 mg/kg,
ivn-dog
242
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Neutralization
(Acetic acid,
sodium hydroxide)
106
Water: acetic acid,
sodium hydroxide
Air: acetic acid
Separator
Dye & color intermediate;
pharmaceutical cinnamic
acid; soaps; photo; puri-
fication of glucose; meat
preservation; medicine;
electroplating; tanning;
dehydrating agent; buffer
in foods; laboratory
reagent
1)287
2)32
3)975
Salt Formation,
Neutralization
(Benzole acid,
sodium hydroxide,
charcoal or
potassium perma-
ganate)
331 Water: benzoic acid,
sodium hydroxide,
sodium benzoate
5.4/1973 Fungicide; bactericide;
food preservative; cor-
rosion inhibitor; alkyd
resin; plasticizers; dyes
1)770
2)196
3)976
7)3-428
9)199
Addition
(Cellulose,
sodium hydroxide,
sodium chloro-
acetate, methanol
or ethanol)
112 Water: sodium hydro-
xide, alkali cellulose,
sodium chloroacetate,
chloroacetic acid,
sodium glycolate,
methanol or ethanol
29.5/1970 Textile manufacturing 1)297
31.1/1973 (sizing); detergents; soaps, 2)287
food products (especially 3)978
dietetic foods & ice 7)4-645
cream), where it acts as 9)200
water binder, thickener,
suspending agent, &
emulsion stabilizer; denti-
frices; coating paper &
paper board to lower
porosity; drilling muds;
emulsion paints; protective
colloid; pharmaceutical;
cosmetics; textiles
Neutralization
(Chloroacetic and
sodium carbonate,
iron, H2DO4 or
PCI3)
109
Water: Cl2,
HCI, CO2
1)292
2)18
3)979
Addition,
Fusion
(Synthesis gas,
sodium
hydroxide)
190
Air: CO
Water: sodium
hydroxide
17.5/1973 Reducing agent; medi- 1)477
cine; manufacture of 2)431
formic acid & oxalic acid; 3)982
organic chemicals; mor- 9)202
dant; tanning; wallpaper
print; plating
(Continued)
243
-------
TABLE A-1. (Continued)
Item
No.
366
Compound
Name and
Formula
Sodium phenate
(Sodium phenoxide)
NaOC6H5
(CeH6NaO)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
000139026
(QR &-NA-)
Toxicology TLV
High toxicity, power- —
ful irr, see Phenol
Carcinogen
—
367
Sorbic acid
(2,4-Hexadienoic)
CH3(CH)4COOH
(C6H802)
000110441
(QV1U2U2)
11,000 rat
LDLo:500 unk-hmn
TDLo:2600mg/
kg/65WTFX:CAR,
scu-rat
368 Styrene
(Phenyl ethylene)
000100425
(1U1R)
(C8H8)
5000 rat LD Lo: 500 mg/kg,
316 mus orl-hmn
LCLo:10,000 ppm/
30M, ihl-hmn
TCLo:600 ppm
TFXMRR, ihl-hmn
TCLo:376ppm
TFXiCNS, ihl-hmn
TCLo:20mg/m3
TFX:GLN, ihl-wmn
LCLo:5000 ppm,
ihl-rat
LCLo: 10,000 ppm,
ihl-mus
LCLo:12gm/m3/
14H, ihl-gpg
USDS air: TWA
100 ppm or
420 mg/m3
CL:200 ppm
PK:600 ppm/5M/
3H
369 Succinic acid
DP COOH(CH2)2COOH
(C6H604)
000110156
(QV2VQ)
LDLo:2000 mg/kg,
scu-frg
244
-------
Process
(Sources Process
of Compound) No.
Salt formation 301
(Phenol, sodium
hydroxide)
Condensation 96
(Crotonaldehyde,
ketene, zinc
carboxylate
catalyst)
Dehydrogenation 3
(Ethylbenzene,
catalysts)
Waste
Associated Wastes Treatment
Air: phenol —
Air: crotonaldehyde, —
sorbic acid
Water: reactants and
products, catalyst
residue
Emission factors: —
hydrocarbons - 1.64,
NO2 - 0.05, particulate -
0.04
Total
Production
106 kg/year
2716/1973
2708/1974
1999/1975
3126/1978
Uses
Antiseptic; salicylic
acid; organic synthesis
Fungicide; food preser-
vative; copolymerization;
upgrading of drying oils;
cold rubber additive;
intermediate for plasti-
cizers & lubricants; cos-
metics; tobacco
References
1)711
3)987
1)262
2)862
3)992
7)18-592
Manufacture: 25% general 1)52
purpose polystyrenes, 23% 2)875
high impact polystyrene, 3)902
15%SBR,6%ABS 5)562
Water: tarry matter
( 13 kg/Mg total)
containing styrene
trimer, stilbene,
biphenyl, napathalene,
phenanthrene, ethyl-
phenanthrene, others
Plant 1:
Flow-0.0235 m3/kg
COD -219mg/l
5.13g/kg
BOD5-69mg/l
1.62 g/kg
TOC - 22 mg/l
0.53 g/kg
Plant 2:
Flow - 0.00548 m3/kg
COD - 426 mg/l
2.34 g/kg
BOD5-70mg/l
0.381 g/kg
TOC - 22 mg/l
0.12 g/kg
resins, 5% styrenated 6)653
polyesters, 5% emulsion 7)19-73
polymers; 4% SAN, 3% 11) 37
styrene-butadiene co- 12)
polymer resins, misc.; 13)45
intermediate; foamed
plastics
Hydrogenation
(Maleic anhydride,
hydrogen, Raney
Ni catalyst)
39 Water and Air: Maleic
anhydride and some
catalyst
Medicine; organic syn- 1)128
thesis; manufacture of 2)876
lacquers, dyes, esters for 3)998
perfumes, succinates; 7)19-145
photo; in foods as a
sequestrant, buffer, neutra-
lizing agent; adhesives;
coatings; elastomers; lubri-
cants; pesticides; Pharma-
ceuticals; paper; surface
active agent; fibers &
textiles
(Continued)
245
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
370 Succinonitrile
CN(CH2)2CN
(C4H4N2)
000110612
(NC2CN)
Highly toxic
LD50:100mg/kg,
ipr-rat
LDLo:150mg/kg,
unk-dog
LDLo:36mg/kg,
unk-rbt
LDLo:2200mg/kg,
unk-pgn
LDLo:1000mg/kg,
scu-frg
371G Su If anil ic acid (ZR XSWQ)
371 (p-Aminobenzene- (ZR DSWQ)
sulfonic acid)
Unknown. Animal
studies indicate
low toxicity &
slight irr
372 Sulfolane
(Thiophene, tetra-
hydro-, 1,1-dioxide)
C4H802S
000126330
(T5SWTJ)
1540 rat
1900 mus
LCLo:4700mg/m3,
ihl-rat
LD50:3180 mg/kg,
skn-rbt
LD50:1080 mg/kg.
373 Synthesis gas
Ditto
374 Terephthalic acid
DP C6H4(COOH)2
000100210
(QVR DVQ)
LD50:1430 mg/kg,
ipr-mus
LDLo:767 mg/kg,
ivn-dog
246
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Substitution
(Acrylonitrile
HCN.benzyltri-
methylammonium
hydroxide catalyst,
t-butyl alcohol
solvent)
275 Water: alcohol, ethylene —
dibromide, potassium
cyanide, bromine,
ethylene cyanide
Organic synthesis
1)662
2)878
3)998
Sulfonation
(Aniline, sulfuric
acid, caustic soda)
Addition & hydro-
genation, sulfona-
tion or hydrogena-
tion
(Butadiene, S02,
H2, Cr, K, Al
oxide catalysts.
Cr-steel reactor)
Steam reforming
(Natural gas.
steam, NiO2>
Steam reforming
(Natural gas.
steam, oxygen.
Ni catalyst)
Oxidation (After
1975 - only air
oxid. in acetic
acid solvent)
(p-Xylene, nitric
acid, oxygen.
acetic acid.
catalyst)
35 Air: SO2, aniline
Water: Caustic soda
60 Air: SO2
Water: Ni, catalyst.
polymeric by-
products
181 Air: H2S, SO2.
ammonia
182
362A Air: NOX (6.5
kg/Mg),particu-
lantes (0.9 kg/
Mg)
Water:
Flow- 3.62 x 10-4,
-9.09 x 10-3
m/kg
COD - 5,400 -
24,950 g/m3
BOD5 - 3,600 -
7,500 g/m3
TOG - 4,200 -
3,730 g/m3
Emission factors:
Xylene - 2.0,
hydrocarbons - 2.0
1)118
3)999
— Extraction of aromatic 1)174
hydrocarbons from oil 2)906
refinery streams; fractiona-3)1000
tion of wood tars, tall oil, 7)19-251
& other fatty acids; poly-
merization solvent;
plasticizer; component of
hydraulic fluid; textile
finishing; dielectrics
— — Organic synthesis; manu- 1)454
facture of alcohols (Oxo
process); low-Btu fuel gas
— — Ditto 1)458
3)1010
— Combined Manufacturing: polyethy- 2)888
total for leneterephthalate-88% '3)1016
diacid and fiber & 7% film; 5% ex- 7)1 5-472
dimethyl port; polyesters with 11)36
ester other glycols (e.g., 1,4- 12)
1937/1974 butanediol) growing; also 13)47
2114/1975 used as a reagent for alkali
2714/1978 in wool; additive to poultry
feeds; intermediate in
herbicide; adhesives; printing
inks; coating & paints
(Continued)
247
-------
TABLE A-1. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD50/mg/kg
Toxicology
TLV
Carcinogen
Also dimethyl ester (1OVR
(DMT), dimethyl DV01)
terephthalate
Unknown
— See phthalic acids,
334
375 Tetrachloroethane
DP (Ethane, 1,1,2,2-
tetrachloro-)
(Acetylene
tetrachloride)
CHCI2CHCI2
(C2H2Cl4)
001299907
(GYGYGG)
200 rat LDLo:50 mg/kg,
orl-hmn
TDLo:30 mg/kg,
TFX:CNS
Generally considered
the most toxic
common chlorinated
hydrocarbon; pro-
duces acute liver
conditions - yellow
atrophy & cirrhosis;
fatty degeneration
of kidneys & heart,
lung & serious mem-
brane hemorrhage &
brain edema observed
in hmn fatilities.
LCLo:1000ppm/4H,
ihl-rat
LD50:3990 mg/kg,
skn-rbt
376 Tetrachlorophthalic
DP anhydride
(C8CI403)
000117088
(T56 BVOVJ-
/G4)
377
Tetraethyl lead
(Plumbane, tetra-
ethyl)
Pb(C2H5)4
(C8H20Pb)
000078002
(2-PB-
2&2&2)
LDLo:17
rat
Powerful poison
LC50:6 ppm,
ihl-rat
LC50:850 mg/m3/
60 M, ihl-rat
LDLo: 10 mg/kg,
ipr-rat
LDLo:31 mg/kg,
ivn-rat
LD50:15 mg/kg,
par-rat
LDLo:500 mg/kg,
skn-dog
USOS air: TWA
0.117mg/m3
(skn)
LDLo:86 mg/kg/
21DI TFX:CAR,
scu-mus
248
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
Esterification
(Terephthalic
acid, methanol)
Emission factors:
hydrocarbons - 63.4,
CO - 36.7, parti-
culate - 0.9, SO2 -
0.7, NO2-0.06
See item
above
See item above
See
item
above
Chlorination 179 Air: kg/Mg
(Acetylene, ethane (1.25),
chlorine, methane (1.25),
antimony tri- tetrachloroethane
chloride (0.50)
catalyst) Water: salts, tetra-
chloroethane
Air: CO2, ammonia,
acetic acid, tere-
phthalic acid
Intermediate manu- 1)450
facture trichloroethylene, 2)390
& s-dichloroethylene; 3)338
one of the most important 7)5-163
"captive" industrial organic
chemicals solvent used in
organic synthesis
Chlorination
(Phthalic anhy-
dride, chlorine,
sulfuric acid,
catalyst)
221 Water: phthalic anhy-
dride, sodium hydrox-
ide, various chloro-
substituted phthalic
anhydride
Acid
scrubber
Intermediate in dyes,
Pharmaceuticals, plastici-
zers, & other organic
materials; f lame-retardant
in epoxy resins
1)543
Addition
(Ethyl chloride,
lead amalgam)
116 Air: butene, ethane,
ethylene
Water: tetraethyl
lead, hydrogen per-
oxide, & sodium
dichromate
Solids: lead sludge
Emission factors:
ethyl chloride - 4.0,
methyl chloride -1.0,
ethylene dichloride -
1.0, ethylene dibro-
mide- 1.0
160.4/1973
211/1974
100% antiknock gasoline
additive; certain ethyla-
tion operations
1)305
2)734
3)770
5)562
6)638
9)205
12)
13)46
(Continued)
249
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
See above item
See above
item
See above
item
See above item
See above item See above item
378 Tetrahydro-
naphthalene
(Naphthalene,
1,2,3,4-tetrahydro)
(Tetralin)
(C10H12)
000119642
(L66&TJ)
2860 rat
Irr; narcotic;
cateracts &
kidney injury
LCLo:275 ppm/
8H/17D, ihl-gpg
379 Tetrahydrophthalic
anhydride
(4-Cyclohexene-1,2-
dicarboxylic
anhydride)
(C8H803)
000085438 LDLo:4590
(T56 BVOV
GUTJ)
rat
LDLo:500 mg/kg,
ipr-mus
380 Tetramethylene-
diamine
(1,4-Butanediamine)
NH2(CH2>4NH2
(C4Hi2N2)
000110601
(Z4Z)
LDLo:1600
rbt
LDLo:80 mg/kg,
ivn-rbt
LDLo:300 mg/kg,
scu-rat
381 Tetramethylethylene- 000110189
diamine
(Ethylenediamine,
N,N,N1,N1-tetramethyl)
(CH3)2NH2CCNH2(CH3)2
(C6H16N2)
(1N1&2N1
&1)
LDLo:1580
rat
Moderate or) &
skn toxicity
382 Toluene-2,4-diamine
DP (2,4-Diaminotoluene)
CH3C6H3(NH2)2
(C7H10N2)
000095807
(ZR CZ D)
LDLo:500
rat
LDLo:50 mg/kg,
orl-hmn
Liver damage;
skn irr
LDLo:50 mg/kg,
unk-rat
LDLo:200 mg/kg,
scu-dog
LDLo:350 mg/kg,
unk-dog
LDLo:400 mg/kg,
unk-rbt
LDLo:200 mg/kg,
unk-gpg
TDLo:11 gm/kg/
36WC,TFX:CAR,
orl-rat
Toluene-2,4-diisocyanate,
seeSSADD
250
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses
Electrolysis 117 — — See above See above item
(Ethyl chloride, item
magnesium, lead,
tetrahydrofuran
or diethyleneglycol
dibutyl ether)
Hydrogenation 215 Air: hydrogen, — — Solvent; chemical
(Naphthalene, naphthalene, tetra- intermediate
hydrogen, Ni hydronaphthalene
catalysts)
References
1)307
1)529
2)579
3)1017
7)13-687
Diels-Alder
reaction
(1,3-butadiene,
maleic anhydride,
benzene)
40
Air: benzene
Chemical intermediate for 1)130
light colored alkyds, poly- 2)329
esters, plasticizers & 3)1017
adhesives; intermediate
for pesticides; hardener
for resins
Chemical intermediate
Alkylation
(Ethylenediamine,
methyl chloride,
ethanol or
butanol)
Air: methyl
chloride, solvent
Water: sodium
hydroxide
2)420
3)1019
Reduction
(Dinitrotoluene,
hydrogen)
343
Water: toluidine
(11gm/kg),
toluenediamine
(9.8gm/kg)
87.6/1973 Dye intermediate; direct 1)791
oxidation black for furs 2)914
& hair; source for 3)1035
toluene-2,4-diisocyanate
(Continued)
251
-------
TABLE A-1. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
383 p-Toluene sulfonamide 000070553 75 bdw
3642 2 /"7Q\A/B n^
(C7HgNO2S)
High orl & ipr
toxicity
LD50:250 mg/kg,
ipr-mus
384G Toluenesulfonic acids
DP (3 isomers)
025231463
(WSQR X)
(C7H803S)
384 p-Toluenesulfonic acid 000104154 400 mus
(WSQR D) 248° rat
Details unknown.
Animal experiments
show moderate
systemic toxicity &
high irritation
385
DP
p-Toluenesulfonyl
chloride
CH3CeH4SO2CI
(C7H7CIO2S)
026763713
(WSGR D)
386G Toluidines (3 isomers)
DP CH3C6H4NH2
(C7H9N)
(ZRX)
Severe systemic
disturbance, head-
ache, weakness,
breathing difficulty,
air-hunger, psychic
disturbances,
bladder & kidney
irr
386 m-Toluidine
000108441 974 rat
(2RC)
LD50:150 mg/kg,
ipr-mus
TDLo:6.6 mg/kg/
19WI TFX:NEO,
orl-rat
387 o-Toluidine
000095534 900 rat
LDLo:300
cat
LDLo:5 frg
(ZR B)
LD50:150 mg/kg,
ipr-mus
LD50:3250-mg/kg,
skn-rbt
USOS air: TWA
5 ppm (skn)
TDLo:8200mg/
kg/24WI TFX:
NEO, orl-rat
TDLo:870 mg/kg/
78WCTFX:NEO
388 p-Toluidine
000106490 656 rat
LD50:42
bdw
(ZRD)
LDLo:50 mg/kg,
orl-hmn
LD50:50 mg/kg,
ipr-mus
252
-------
Process
(Sources Process
of Compound) No.
Ammonolysis, 358
Amination
(Ammonia, toluene-
sulfonyl chloride
Associated Wastes
Air: HC1.NH3
Water: ammonium
chloride, product
Total
Waste Production
Treatment 1 0® kg/year Uses
— — Organic synthesis;
plasticizers & resins;
fungicide & mildewcide
in paints & coatings
References
1)821
2)915
3)1036
Sulfonation
(Toluene, oleum)
79 Air: toluene
Water: sodium sul-
fate, toluene, toluene
sulfonic acid
Emission factors:
toluene - 1.0
Scrubber
Dyes; organic synthesis; 1)211
acid catalyst 12)
Ditto
Ditto Ditto
Ditto
Ditto
2)916
3)1036
Sulfonation &
substitution,
condensation
(toluene, oleum,
PCI 3)
357 Air: HCI
Water: sulfuric acid,
hydrochloric acid,
chlorine
Organic synthesis; inter-
mediate in the systhesis
of saccharin & dyestuffs
1)819
Reduction
(Nlitrotolulene,
hydrochloric
acid-iron, or
hydrogen,
catalyst)
341
Water: toluidine
hydrochloride
Air: particulates,
HCI
Dyes
1)787
3)1036
7)2-421
Ditto
Ditto Ditto
— Ditto
3)1036
2)917
Ditto
Ditto Ditto
Ditto
2)917
3)1036
Ditto
Ditto Ditto
Ditto
2)917
3)1036
7)2-421
(Continued)
253
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
389 Trichloroaniline
CI3C6H2NH2
390G Trichlorobenzenes
DP (3 isomers)
(GR XG XG)
390 1,2,4-Trichloro-
benzene
000120821 756 rat
(GRBGDG) 766mus
Liver injury;
chronic local;
causes loss of
hair in experi-
mental animals
1,2,3- and 1,3,5-
isomers have
similar toxicity
Air: 5 ppm
391 1,1,2-Trichloroethane,
1,1,2-trichloro)
CICH2CHCI2
(C2H3CI3)
000079005
(GYGIG)
1140 rat
LDLo:500
dog
LDLo:50 mg/kg,
orl-hmn
Narcotic; irr to
eyes, nose &
lungs; injurious
to liver & kidneys
LCLo:500 ppm/
8H, ihl-rat
LD50:227 mg/kg,
scu-mus
LDLo:95 mg/kg,
ivn-dog
LDLo:500 mg/kg,
scu-rbt
USDS air: TWA
10 ppm (skn)
Ditto
Ditto
Ditto
Ditto
Ditto
392
Trichloroethylene
(Ethylene,
trichloro)
CHCICCI2
(C2HCI3)
000079016
(GYGV1G)
4920 rat
LDLo: 5860
dog
LDLo:50 mg/kg,
orl-hmn
LDLo:857 mg/kg,
orl-hmn
TCLo:6900mg/m3/
10M,TFX:CNS,
ihl-hmn
TCLo:160ppm/83M
TFX:CNS, ihl-hmn
TCLo:110ppm/8H,
ihl-man
Narcotic & anesthetic
in high concen.
Additive. Fatalities
due to heart failure
USDS air: TWA
100 ppm or 535
TDLo:351 gm/kg/
78WITFX:CAR,
orl-mus
C: 200 ppm
PK:300ppm/5M/
2H
RECSTDair
TWA: 100 ppm
C: 150 ppm
254
-------
Process
(Sources Process
of Compound) No.
Chlorination 19
(Aniline, HCI,
CCI4 or EtOH
solvent)
Chlorination 6
(Dichlorobenzene,
chlorine, FeCIs)
Chlorination 137
(Ethylene dichlo-
ride, chlorine)
Waste
Associated Wastes Treatment
Air and Water: CCI4, —
EtOH,Cl2, HCI,
aniline
Water: traces di-, —
tri-, and poly-
chlorinated
benzenes
Water: chlorine, HCI, HCI scrubber
sodium hydroxide.
ethylene dichloride.
trichloroethane.
Air: HCI, organic
chlorides
Emission factors:
hydrocarbons - 5.0
CO --.1
Total
Production
106 kg/year Uses
— —
12.9/1973 Solvent in chemical
manufacturing; dyes &
intermediate; di-
electric fluid; synthetic
transformer oils; lubri-
cants; heat-transfer
medium; insecticide.
coolant
170.1/1971 Manufacture of vinyli-
193.0/1974 dene chloride; solvent for
cleaning precision instru-
ments; aerosol propel lant;
metal degreasing; pesti-
cide; solvent for fats, oils,
waxes, resins, other pro-
ducts; organic synthesis
References
1)83
1)59
2)166
3)1043
7)5-265
9)24
1)359
2)398
3)1044
6)656
7)5-159
12)
Oxychlorination
(Ethylene dichlo-
ride, hydrogen
chloride, oxygen)
138
Ditto
Ditto
1)361
6)656
See carbon
tetrachloride
140
Emission factors:
trichloroethylene -
57.0, CCI4 - 26.0,
dichloroethane -
26.0, tetrachloro-
ethane - 0.1
205/1973 90% metal cleaning; 10% 1 )364
176/1974 extraction, solvent, export;2)422
used for degreasing & dry 3)1045
cleaning; extraction .5)563
solvent for oils, fats, 7)5-193
waxes; solvent dyeing; 9)205
refrigerant & heat 12)
exchange liquid; organic 13)46
synthesis; fumigant;
cleaning & drying elec-
tronic parts; manufacturing
food additives for human
consumption
(Continued)
255
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
392 (Continued)
See above item
See above
item
See above
item
LCLo:8000ppm/4H,
ihl-rat
LCLo:3000ppm/2H,
ihl-mus
LD50:34 mg/kg,
ivn-mus
LD50:1900 mg/kg,
ipr-dog
LDLo: 150 mg/kg,
ivn-dog
See above item
See above
item
See above item
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
393 Trichlorofluoro-
methane
(Methane, trichloro-
fluoro) (Freon 11)
FCCI3
(CCI3F)
000075694
(GXGGF)
Anesthesia
LDLo:100,000
ppm/20M, ihl-rat
USDS air: TWA
1000 ppm or
5600 mg/m3
394 1,2,3-Trichloropropane 000096184 320 rat
(Propane, 1,2,3- (G1YG1G) LDLo:200
trichloro) dot
CH2CICHCICH2CI
(C3H5CI3)
Cumulative toxicity
LCLo: 1000 ppm/
4H, ihl-rat
LD50:1770 mg/kg,
skn-rbt
USDS air: TWA
50 ppm or 300
mg/m3
395 1,1,2-Trichloro-
1,2,2-Trif luoroethane
(Ethane, 1,1,2-trichloro-
1,2,2-trifluoro)
(Freon 113)
CCI3CF3
(C2CI3F3)
000076131 LDLo:45rat
(GXGFX
TFF)
TCLo:4500 ppm
TFX:CNS, ihl-hmn
LCLo:87,000 ppm/
6H ihl-rat
USDS air: TWA
1000 ppm or
7600 mg/m3
396
Triethanolamine
(Ethanol, 2,2',2"-
nitrilotris)
000102716 8000 gpg
(Q2N2Q2Q) 868°rat
(C6H15N03)
LDLo:5000 mg/kg,
orl-hmn
Kidney & liver
damage in animals
under chronic
exposure
256
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
See perch loro-
ethylene
180
See above item
1)452
Ditto
235
Ditto
1)573
See dichloro- 163
difluoromethane
152/1973
156.2/1974
50% aerosol propellants,
28% refrigerants, 10%
plastics, 5% solvent, 7%
blowing agent, export
& miscellaneous
1)417
2)542
3)693
6)631B
9)205
13)47
Chlorination 321 Air: HCI, chlorine,
(Propylene, chlorinated hydro-
chlorine, carbons
propylene Water: sodium
dichloride) hydroxide, chlorine,
NaCI, hydrochloric
acid
Paint & varnish remover; 1 )747
solvent; degreasing agent 2)757
3)1047
5)562
Fluorochlorination
(Perch loroethylene,
hydrogen fluoride,
chlorine, partially
fluorinated SbC\$
or ZrC>2 catalyst)
141 Air & Water:
chlorofluorocarbons
Water: sodium
hydroxide, hydro-
chloric acid
Emission factors:
HCI -2.0, freon-1.0
Scrubber
Dry cleaning solvent; fire
extinguishers; refrigerant;
air-conditioning units; to
make chlorotrifluoro-
ethylene; blowing agent;
polymer intermediate;
solvent drying; drying
electronic parts & pre-
cision equipment
1)367
2)399
5)562
12)
See diethanolamine 149
44.8/1973 Fatty acid soaps used in 1)369
49/1974 drycleaning, cosmetics, 2)408
household detergents, & 3)1049
emulsions; wool scouring; 6)622
textile antifume agent & 9)201
water-repellant; dispersion
agent; corrosion inhibitor;
softening agent; humectant,
& plasticizer; insecticide;
chelating agent; rubber
accelerator
(Continued)
257
-------
TABLE A-1. (Continued)
Item
No.
397
Compound
Name and
Formula
Triethylamine
(C2H5)3N
(C6H15N)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg Toxicology TLV Carcinogen
000121448 460 rat Kidney & liver USOS air: TWA
(2N2&2) 546 mus damage in experi- 25 ppm or 100
mental animals mg/m^
LCLo:1000 ppm/
4H, ihl-rat
LD50:570 mg/kg.
skn-rbt
LCLo:1000 ppm/
4H, ihl-gpg
398 Triethylene glycol 000112276 18,500 mus
(CH2OCH2CH2OH)2 (Q2O2oQ) 17,000 rat
(C6H1404)
LDLo:5000 mg/kg,
orl-hmn
9739 scu-mus
LD50:8750 mg/kg,
scu-mus
LD50:6500 mg/kg,
ivn-mus
399
Triethylene glycol
dimethyl ether
(C8H1804)
000112402
(102020201)
See glycol ethers
400 Triisobutylene
(1-Propene, 2-methyl-,)
(CH3)2C:C[C(CH3)302]
(C12H24)
007756947
(1N1&1)
401
Trimethylamine
(Methanamine,n,n-
dimethyl)
(CH3)3N
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
See diethylamine 120
Emission factors:
hydrocarbons - 2.0,
NH3- 1.0
13.0/1974 Catalytic solvent in 1)316
chemical synthesis; accele- 2)931
rator activators for rubber; 3) 1050
wetting; penetrating &
water proofing agent of
quaternary ammonium
types; curing & hardening
of polymers (e.g., core-
binding resins); corrosion
inhibitor propel Iant; print
remover
5)562
7)2-123
12)
See diethylene 144
glycol
51.3/1973 30% natural gas dehydra- 1)374
50.2/1974 tion, 17% humectant, 15% 2)932
printing ink, 12% vinyl 3)1051
plasticizers, 8% polyester 6)628
& polyurethane resins, 9)204
12% Udex extraction 12)
solvent 13)47
See diethylene 150
glycol dibutyl
ether
Solvent for gases; coupling 1)384
immiscible liquids 3)1052
See diisobutylene 75
Synthesis of resins, &
industrial organic com-
pounds; lubricating oil
additive, raw material for
alkylation in producing
high octane motor fuels
1)200
See dimethylamine 192 Emission factors:
hydrocarbons - 2.0
13.1/1973 Synthesis: 11.6% choline 1)534
chloride, 1.5% other (e.g., 3)1058
pharmaceutical), other 6)608
quaternary ammonium 9)200
salts; warning agent for 12)
natural gas; manufacture 13)47
of disinfectants; flotation
agent; insecticide attractant
Ammonolysis & 183
dehydration, &
ammonolysis 184
(Ammonia, carbon
dioxide)
Air: ammonium car-
bamate, ammonia,
urea particulates,
monoethanolamine
3305/1973 About 76% fertilizer, 12% 1)460
3447/1974 animal feed, 4% urea- 1)462
3359/1975 formaldehyde resins, 2% 2)942
melamine; plastics; chemi- 3)467
cal intermediate; stabilizer 6)657
in explosives; medicine; 7)21-54
adhesives; separation of 11 )37
hydrocarbons as urea 13)47
adducts); sulfamic acid
(Continued)
259
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
402 (Continued)
DP
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgQ, mg/kg Toxicology
TLV Carcinogen
403
Vinyl acetate
(Acetic acid vinyl
ester)
CH3COOCHCH2
(C4H602)
000108054
(1V01V1)
Skn irr; narcotic in
the presence of an
inhib
LCLo:4000 ppm/
4H, ihl-rat
LDLo:500 mg/kg,
ipr-rat
USDS air: TWA
10 ppm or 30
mg/m3
Ditto
Ditto
— Ditto
Ditto
404
Vinyl chloride
(Ethylene, chloro)
(Vinyl chloride
nonomer, VCM)
CH2CHCI
(C2H3CI)
000075014
(G1U1)
500 rat TC Lo: 20 ppm
TFX:CVS, ihl-hmn
Circulatory & bone
changes in hmn
workers; anesthetic;
liver injury in rats
&rbt
USOS air: TWA Hmn carcinogen
1 ppm; Cl 5 ppm of the liver
TCLo:500ppm/
4YI
TFX:CAR,ihl-
man
LCLo:250ppm/
4H/130WI
TFX:CAR, ihl-rat
TCLo:250ppm/
35WI
TFX:CAR, ihl-mus
TDLo:500ppm/
4H/30WI
TFX:CAR, ihl-ham
TCLo:600 ppm/
4H/(12-18Dpreg),
TFX:CAR, ihl-rat
260
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
106 kg/year
Uses
References
production; flame-proofing
agent; viscosity modifier
for starch or casein-based
paper coatings; reported
helpful in treating sickle-
cell anemia
Oxyacetylation
(Ethylene, acetic
acid, oxygen, Pd
catalyst)
95 Air: ethylene, acetic
acid, vinyl acetate,
acetaldehyde
Solids: Polymers
and mixed aldehydes
Scrubber 683/1973 Manufacture: 39% poly- 1)260
638/1974 viny(acetate latics, 16% 2)34
516/1975 polyvinylacetate resins, 3)1086
764/1978 15%polyvinylalcohol 7)21-330;
(& butyral, formal derivs.), 340
7% vinyl chloride co- 11)37
polymers, 4% ethylene 13)47
copolymers, 1% exports,
2% miscellaneous; latex
paints; paper coating;
adhesives; textile finishing;
safety glass interlayers
Oxyacetylation
(Acetylene, acetic
acid, oxygen, Zn
acetate on carbon
catalyst)
174 Air: May emit traces
of light ends (methyl
acetylene, allene,
acetylene)
Water: May contain
acetic acid
Ditto
Ditto
1)441
Pyrolysis 133 Air: kg/Mg
(Ethylene HCI (0.1), vinyl
dichloride) chloride (5), 1,2-
dichloroethylene
(0.15), 1,1-
dichloroethylene
(0.4), acetylene
(1.5), acetaldehyde
Water:
Flow- 1.27m3/454
kg
COD - 2.733 kg/m3
3.475 kg/454
kg
TOC-0.120kg/m3
0.150kg/
454kg
Solids: kg/Mg
Ethylene dichloride
(0.8), heavy bottom
tars, and solids (0.52)
Scrubber. 2432/1973 97% Polyvinyl chloride
Distillation 2555/1974 resins; organic synthesis;
recovery 1907/1975 adhesives for plastics;
columns for 3161/1978 plasticals; decorative
HCI, VCM. coatings; leather sub-
Heavy bottoms stitutes; drinking cups;
(higher chlori- printing ink; plastici-
nated organics) zers; building and
sent to waste packaging industry
disposal
1)349
2)418
3)1087
7)21-402
11)37
13)47
(Continued)
261
-------
TABLE A-1. (Continued)
Item
No.
405
Compound
Name and
Formula
Vinylidene chloride
(Ethylene, 1,1-
dichloro)
CH2CCI2
(C2H3CI)
Chem. Abstr.
Registry No.
(WLN)
000075354
(GYGU1)
Oral Toxicity,
LD50/ mg/kg Toxicology
LDLo:5750 TCLo:25 ppm
dog TFX:SYS, ihl-hmn
LCLo:10,OOOppm/
24H, ihl-rat
LDLo:225 mg/kg.
ivn-dog
LDLo: 3700 mg/kg,
scu-rbt
TLV
10 ppm; 40
mg/m3
(proposed
1974)
Carcinogen
Experimental car-
cinogen
3)1088
406
Vinyltoluene
(Styrene, methyl)
001319739
(1U1R X)
3160 mus
LDLo:4900
rat
(C9H10)
Chronic damage to
kidneys & liver
LC50:3020 mg/m3,
ihl-mus
TCLo:29 mg/m3/
13WITFX:TER,
ihl-gpg
407G Xylenes (mixed)
(1RX)
LC50:6700 ppm/
4H, ihl-rat
NIOSH
recommend
std air: TWA
100 ppm or
435 mg/m3
407
DP
m-Xylene
C6H4(CH3)2
(C8Hio>
000108383
(1RC)
5000 rat
LCLo:2010ppm/
24H, ihl-mus
LCLo:8000ppm/
4H, ihl-rat
LDLo:2000 mg/kg,
ipr-rat
LDLo:5000 mg/kg,
scu-rat
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
408
DP
o-Xylene
C6H4(CH3)2
000095476 LDLo: 500
(1R B)
rat
LDLo: 1500 mg/kg,
ipr-rat
LDLo:2500 mg/kg,
scu-rat
LCLo: 6920 ppm,
ihl-mus
LCLo:6125 ppm,
ihl-rat
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
262
-------
Process
(Sources Process
of Compound) No.
Oehydrochlorination 139
(1,1,2-Trichloro-
ethane, aqueous
sodium hydroxide,
ferrous sulfate and
caustic soda
solutions)
Waste
Associated Wastes Treatment
Water: Flow 1.69 dm3/
sec, sodium hydroxide
(45.5 kg/Mg), sodium
chloride (605.5 kg/
Mg, ferrous sulfate
Air: vinylidene
chloride, 1 ,1 ,2-
trichloroethane
Emission factors:
hydrocarbons - 4.0
Total
Production
106 kg/year Uses
77.2/1974 Copolymerized with vinyl
chloride or acrylonitrile
to form various kinds of
Saran; other copolymers
are also made; adhesives;
component of synthetic
fibers; molded, extrusion
& lacquer resins
References
1)362
2)420
3)1088
7)21-296
12)
Alkylation &
dehydrogenation
(Ethylene, toluene)
130 Water: toluene, HCI,
aluminum salts, sodium
hydroxide, NaCI, tars
Mostly unsaturated poly- 1)337
esters; solvent, 2)875
intermediate 3)1090
13)48
2,627/1974 About 72% separated into 2)960
2,309/1975 3)1095
391/1978 11)36
13)48
See benzene &
ethylbenzene
359
Solvent; intermediate 1)826
for dyes & organic syn- 2)960
thesis, especially iso- 3)1094
phthalic acid; insecticides; 5)563
aviation fuel
See benzene
349
Ditto
Ditto
1)803
2)960
See benzene &
ethylbenzene
359 Emission factors:
hydrocarbons - 20.0
485/1973 About 61% synthetic
480/1974 phthalic anhydride;
308/1975 vitamin & pharmaceuti-
461/1978 cal synthesis; dyes;
insecticides; motor
fuels; exports
1)826
2)960
3)1094
5)563
6)662
11)37
12)
13)48
See m-xylene &
benzene
349
Ditto
Ditto
1)803
(Continued)
263
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
409 p-Xylene
DP CgH4(CH3)2
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
See benzene &
ethylbenzene
359
1057/1973 Synthesis: about 60% DMT 1)826
1230/1974 25% TPA (used in polyester 2)960
1102/1975 resins & fibers, e.g., 3)1095
1588/1978 "Dacron", "Mylar", 5)563
"Terylene"); vitamin 6)663
& pharmaceutical synthesis; 11 )37
insecticide; exports 13)48
See m-xylene &
benzene
349
— Ditto
Ditto
1)803
See a-cresol
See o-, m-, and
p-cresol
78
&
82
Disinfectants; solvents,
Pharmaceuticals, insecti-
cides & fungicides; plasti-
cizers; rubber chemicals;
additives to lubricants &
gasoline; manufacture of
polyphenylene oxide
(2,6-isomer only); wetting
agents; dyestuffs
1)209
1)217
2)960
Ditto
Ditto
Ditto
2)960
Ditto
Ditto
Ditto
2)960
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
2)960
3)1095
Methylation
(Phenol,
methanol,
alumina
catalyst)
297 Air: CH3OH, phenol
Water: ethers of
cresols & xylenols,
methanol, phenol
1)703
2)960
9)326
(Continued)
265
-------
TABLE A-1. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5£),mg/kg
Toxicology
TLV
Carcinogen
41 5G Xylidine
DP (mixed 2,3-; 2,r-;
2,5-;
2,60)
001300738
(ZR X X)
(C8HnN)
LDLo:610 rat
LDLo:620 rbt
LDLo:50mg/kg,
orl-hmn
Liver & blood
damage; severe &
possible fatal
intoxication
through skn abs
LDLo:149 ppm,
ihl-mus
LDLo:120mg/kg,
ivn-cat
LDLo:240mg/kg,
ivn-rbt
USDS air: TWA
5 ppm (skn)
or 25 mg/m3
(skn)
415 2,3-xylidine
000087592 933 rat
(ZRBC) 1072 mus
Ditto
Ditto
416 2,4-xylidine
000095681 467 rat
(ZR B D)
250 mus
Ditto
Ditto
417 2,5-xylidine
000095783 1297 rat
(ZR B E) 841 mus
Ditto
Ditto
418 2,6-xylidine
000087627
(ZR B F)
840 rat
707 mus
Ditto
Ditto
266
-------
Process
(Sources
of Compound)
Nitration &
reduction
(Nitroxylenes
hydrogen, MoSj
on inert support
catalyst, aqueous
NaOH wash)
Process
No. Associated Wastes
364 Air: Some H2
Water: sodium
hydroxide
Total
Waste Production
Treatment 1 0^ kg/year
—
Uses
Dye intermediate; organic
synthesis; pharmaceuti-
cals; vitamins
References
1)840
2)961
3)1095
5)563
Ditto
Ditto Ditto
Ditto
2)961
3)1095
Ditto
Ditto Ditto
Ditto
2)961
3)1095
Ditto
Ditto Ditto
Ditto
Ditto
Ditto
Ditto Ditto
— Ditto
2)961
3)1095
7)2-421
267
-------
TABLE A-2. INDUSTRIAL ORGANIC CHEMICALS, ADDENDUM-TOXICITY,
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
1 Acetyl chloride
(125)
000075365
(GV1)
— TCLo:2ppm/1M — —
TFX.TRR, ihl-hmn
High toxicity ihl &
orl
2 Adiponitrile
(185)
000111693
(NC4CN)
300 rat
LD50:40 mg/kg,
ipr-mus
LD50:50 mg/kg,
scu-gpg
p-Aminophenol
(Phenol, p-amino)
(235)
000123308
(ZR DQ)
375 rat LDLo:50 mg/kg,
orl-hmn
TCLo:1 mg/m3
TFX:BLD, ihl-hmn
LDLo:470 mg/kg,
scu-mus
LDLo: 1500 mg/kg,
scu-gpg
4G Amylphenols
(7 isomers)
Amylphenol, n
Phenol-p-
pentyl
TDLo:4100 mg/kg/
12WITFX:NEO
(290) Amyphenol, p-tert
00080466
(QR D1Y)
3080 rat
LD50:2000 mg/kg,
skn-rat
5 Benzidine
DP
000092875
(ZR DR D2)
309 rat
214 mus
200 dog
LDLo:400 mg/kg,
scu-dog
USDS
carcinogen
TCLo:18mg/m3/
13YI
TFX:CAR; ihl-man
TDLo:10mg/m3/
56WI
TFX:CAR, ihl-rat
TDLo: 4500 mg/kg/
30DI
TFX:CAR,orl-rat
TDLo:2100 mg/kg/
35WI
TFXiCAR, scu-rat
Benzoyl peroxide
000094360
(RVOOVR)
950 rat LDLo:500 mg/kg,
orl-hmn
TCLo:12mg/m3,
TFX:PUL, ihl-hmn
LCLo:700ppm,
ihl-mus
USDS air: TWA TDLo:25 gm/kg/
5 mg/m3 42WI
TFX:NEO, skn-mus
268
-------
PROCESS, WASTE, PRODUCTION AND USE DATA
Process
(Sources Process
of Compound) No.
Total
Waste Production
Associated Wastes Treatment 106 kg/year
Uses
References
— Emission factors:
hydrocarbons - 2.0
18.2/1975
2)43
3)336
12)
Emission factors:
butadiene - 33.9,
HCI-81.0
279/1975
2)55
3)344
12)
2)639
3)361
12)
Alkylation
(Phenol,
amylenes,
BF3 catalyst)
311
1)728
Ditto
Ditto
2)648
Ditto
Ditto
2)648
3)377
12)
Dye and pigment raw 2)167
material 3)405
4.0/1973
2)215
3)409
9)
269
(Continued)
-------
TABLE A-2. (Continued)
Item
No.
7
8
Compound
Name and
Formula
1,4-Butanediol
2,6-di-tert-butyl-p-
cresol
(Butylated hydroxy
toluene, BHT)
Chem. Abstr.
Registry No.
(WLN)
000110634
000128370
(1X&&R
BQ E CX)
Oral Toxicity,
LD5Q, mg/kg
1525 rat
2062 mus
2531 rbt
1 200 gpg
2450 rat
2)312
35 10 rat
3)551
1040 mus
Toxicology TLV
LDLo:500 mg/kg,
ipr-mus
LD50: 1370 mg/kg,
ipr-rat
TDLo:5500 mg/kg, Air:10mg/m3
(preg)
TFX:TER,orl-rat
LDLo: 250 mg/kg,
ipr-mus
Carcinogen
—
LDLo:940
mg/kg, orl-
cat
LDLo:2100
mg/kg, orl-
rbt
9 tert-butyl
hydroperoxide
000075912 406 rat
(QOX) 710mus
LC50:500 ppm/4H,
ihl-rat
LC50:350 ppm/4H,
ihl-mus
LD50:790 mg/kg,
skn-rat
LD50:87 mg/kg,
ipr-rat
10 di-tert-butyl
peroxide
(t-butyl peroxide)
000110054
(1X&&OOX)
LD50:3210 mg/kg,
ipr-rat
TDLo:585 mg/kg
TFX:NEO, unk-mus
11 2-Butyrolactone
Experimental car-
cinogen, 3)453
12
tert-butyl
perbenzoate
(peroxybenzoic
acid, t-butyl)
000614459
(1XOOVR)
4160 rat
2500 mus
TDLo:241 mg/kg/
I, TFX:NEO, unk-
mus
13 Calcium stearate
14 Caprolactam
(785)
000105602
(T7MVTJ)
2140 rat TDLo:7 ppm
TFX:IRR, ihl-hmn
TDLo: 1410 mg/kg,
skn-rbt
LDLo:950 mg/kg,
scu-gpg
USDS air: TWA Polycaprolactam
Vapor-5 ppm or TDLo:5 film discs/
20 mg/m3 rat
T LV-dust -1 T F X: N EO, imp-rat
15 Caprolactone
4290 rat
270
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
2)238
14.5/1973 — 2)312
3)551
9)
2)246
3)447
1.1/1973 — 2)246
3)553
9)
3)453
1.1/1973 — 2)626
3)450
9)
Emission factors: — 324/1975 — 2)259
chloroethylene - 1.0 416/1978 3)467
12)
(Continued)
271
-------
TABLE A-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
16
(90S)
Chlorobenzotri-
chloride
(GXGGR XG)
17 o-chloro-
nitrobenzene
(o-nitrochlorobenzene)
(see also 105DP)
000088733
(WNR BG)
288 rat
135 mus
18
Chloroprene
(1,3-butadiene,
2 chloro)
000126998
(1UYG1U1)
LDLo:1600
rat
TCLo:80 ppm
TFX:CNS
Moderate orl & ihl
TDLo:39 mg/m3/
4H/48D
TFX:MUT, ihl-rat
LCLo:600 mg/m3/
8H, ihl-mus
LCLo:2500 mg/m3/
8H, ihl-cat
LDLo:96 mg/kg,
ivn-rbt
USDS air: TWA
25 ppm (skn)
or 90 mg/m3
19
Chlorotrifluoro-
methane
(Freon13)
000075729
Mild irr
20
Citronellol
(6-octen-1-ol,
3,7-dimethyl)
000106229 3450 rat
(Q2Y&3UY)
LDLo:100 mg/kg,
ivn-mus
LD50:2650 mg/kg,
skn-rbt
21 Cyclohexanone
oxime
000100641
(L6YTJ
AUNQ)
LD50:250 mg/kg,
ipr-mus
22 Cyclooctadiene
(1170)
23
Tris(2,3-dibromo-
propyl phosphate)
(TBPP)
1010 rat
Experimental
carcinogen
24
Dibutylmaleate
000105760 3730 rat
(40V1U1VOR)
UD50:150 mg/kg,
ipr-mus
272
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
2)158
3)496
2)236
3)499
Emission factors: — 11/1975 — 2)536
CCI4 -1.0, HCI - 3)839
1.0 9)
12)
2)604
2)327
Emission factors: — 11/1975 — 9)
hydrocarbons - 3.0 12)
Textile flame retardant
5/1973 — 2)521
3)552
9)
(Continued)
273
-------
TABLE A-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
25
m-D ich lorobenzene
26 Dichloromethyl ether 000542881
(Ether, dichloromethyl)
210 rat
LCLo:8ppm/4H,
ihl-rat
LC50:25 mg/m3/
6H, ihl-mus
LD50:280 mg/kg,
skn-rbt
USDS
carcinogen
TDLo:100ppb/4WI
TFX:CAR, ihl-rat
TDLo: 135 mg/kg/
58DI
TFX:CAR,scu-rat
TDLo:5 mg/m3/
82DI
TFX:NEO, ihl-mus
TDLo:5520 mg/kg/
23WI
TFX:NEO, skn-mus
27 2,4-Dichlorophenol 000120832 580 rat
(QRBGDG) 1600mus
LD50:430 mg/kg,
28 Diethylenetriamine 000111400 1080 rat
(Z2M2Z)
LD50:74 mg/kg,
ipr-rat
LD50:1090 mg/kg,
skn-rbt
Air: TWA
1 ppm (skn)
29 N,N-Dimethylaceta- 000127195
mide
(1VN1&1)
TCLo:20ppm
TFX:SYS, ihl-hmn
TDLo:600 mg/kg
(preg)
TFX:TER, ipr-rat
LD50:2240 mg/kg,
skn-rbt
USOS air: TWA
10 ppm (skn)
or 35 mg/m3
30
Dimethylamino-
ethanol
000108010
(Q2N1&1)
2340 rat
LD50:1020 mg/kg,
ipr-mus
LD50:961 mg/kg,
scu-mus
LD50:1370 mg/kg,
skn-rbt
31 Dimethylcarbamoyl-
chloride
000079447
(GVN1&1)
1000 rat
Strong irr &
lachrymator
LDLo: 1.0 mg/kg,
scu-mus
TCLo:1 ppm
TFX:CAR, ihl-rat
TDLo:17gm/kg/
70WI
TFX:CAR, skn-mus
TDLo:2560 mg/kg/
64!
TFX:NEO, ipr-mus
TDLo:5200 mg/kg/
26WI
TFX:CAR, scu-mus
274
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
3)557
12)
— — 2)412
3)564
2)643
3)565
2)365
3)577
2)4
3)595
1.9/1973 — 2)404
3)596
2)276
3)601
(Continued)
275
-------
TABLE A-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
32
(1495)
1,1-Dimethylhydrazine 000057147 122 rat
(ZN1&1)
LC50:252 ppm/4H,
ihl-rat
LD50:60 mg/kg,
ipr-mky
LC50:3580ppm/
15M, ihl-dog
USDS air: TWA TD Lo: 7902 mg/kg/
0.5 ppm (skn) 30WC
or 1 mg/m3 TFX:CAR, orl-mus
33 4,6-D initro-o-cresol 000534521 25 rat
(WNR BZ C 47 mus
ENW)
LDLo:5 mg/kg,
orl-hmn
TCLo:1 mg/m3
TFX:CNS, ihl-hmn
LCLo:40mg/m3,
ihl-cat
USDS air: TWA
0.2 mg/m3 (skn)
34 Dioctyl maleate
35 Diphenylhydrazine
00053057
36
di-n-Propyl-amine
000142847 930 rat
(3M3)
LCLo:100ppm/4H,
ihl-rat
LD50:1250 mg/kg,
skn-rbt
37 Dodecylbenzene
Moderate toxicity
38
Ethyleneimine
000151564 15 rat
(T3MTJ)
LDLo:5 mg/kg,
orl-hmn
LCLo:25 ppm/8H,
ihl-rat
LC50:400 mg/m3,
ihl-mus
LD50:3800 g/kg,
ipr-rat
USDS
carcinogen
TDLo:20 mg/kg/
670I
TFX:CAR,scu-rat
TDLo: 235 mg/kg/
76WC
TFX:CAR, orl-mus
39
2-Ethyl hexyl
acrylate
000103117
(442&10V1
5660 rat
2)49
6500 rat
3)665
LD50:1600 mg/kg,
skn-rbt
40
2-Furaldehyde
(Furfural)
000098011
(T50J
BVH)
127 rat
425 mus
2300 dog
541 gpg
LDLo:500 mg/kg,
orl-hmn
TDLo:0.6 mg/m3
TFX:EYE, ihl-hmn
USDS air: TWA
5 ppm (skn) or
20 mg/m3
41 Glycerol
Dichlorohydrin
(2091)
000616239 150 rat
(Q1YG1G)
LCLo:125ppm/4H,
ihl-rat
LD50:5 mg/kg,
scu-mus
276
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
1.8/1975 — 2)465
3)607
9)
12)
2)312
3)617
3.5/1973 — 9)
8.3/1973 — 2)373
3)626
9)
217/1973 Detergent alkylate 2)160
239/1978 3)633
2)423
3)662
2)49
3)665
2)432
3)698
3)706
12)
(Continued)
277
-------
TABLE A-2. (Continued)
Item
No.
42
(2145)
43
(2165)
Compound
Name and
Formula
Hexachlorobenzene
(Perchlorobenzene)
Hexamethylenediamine
( 1 ,6-Hexaned iam ine)
Chem. Abstr.
Registry No.
(WLN)
000118741
(G 6-R)
000124094
(Z6Z)
Oral Toxicity,
LD50' m9/kg
3500 rat
4000 mus
1700 cat
"
Toxicology TLV Carcinogen
LDLo:500mg/kg,
orl-hmn
TDLo:500 mg/kg
(7-1 1D preg)
TFX:TER,orl-mus
Moderate irr to — —
skn, eye, mu
mem, via orl & ihl
LCLo:750 mg/m3/
10M, ihl-mus
44 Hexamethylene-
diammoniumadipate
45 Hexamethyl phosphoric 000680319
acid triamide
(phosphoric tri-
amide, hexamethyl)
(1N1&3PO1
N&3PO)
2650 rat (M)
3360 rat (F)
LDLo:3500 mg/kg,
skn-rat
Squamouscell
carcinogen
TCLo:400ppb/
35 WI
TFX:CAR, ihl-rat
46
2-hexanone
(methyl n-butyl
ketone)
000591786
(4V1)
2590 rat
914 gpg
LCLo:6000 ppm/
7H, ihl-gpg
USDS air: TWA
100 ppm or
410 mg/m3
47
3-hexanone
(ethyl-n-Propyl
ketone)
(2V3)
3360 rat
LCLo:4000 ppm/
4H, ihl-rat
48
Hexylalcohol
(1-hexanol)
000111273
(Q6)
720 rat
1950 mus
LDLo:500 mg/kg,
orl-hmn
LD50:3100 mg/kg,
skn-rbt
49 Hydrazine solutions
(data for hydrazine)
H2N-NH2
000302012 60 rat
(ZQ)
LC50:570 ppm/4H,
ihl-rat
LC50:252 ppm/4H,
ihl-mus
USOS air: TWA
1 ppm (skn) or
1.3 mg/m3
TDLo:410 mg/kg/
26WC
TFX:CAR, orl-mus
TDLo:400 mg/kg/
5WI
TFX:CAR, ipr-mus
50
lonone
4950 rat
(LGUTJ A E
E F1U1V1 &
L6UTJ A
B1U1V1 CO
51
Isopentane
000078784
(24)
— Simple asphyxiant
278
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
— Emission factors:
hydrocarbons - 2.0,
HCI- 1.0
1.5/1975
2)61
3)716
9)
12)
Emission factors:
adiponitrile - 0.1
2)456
3)720
12)
350/1973
9)
2)676
3)721
2)458
3)812
2)458
3)723
4.5/1973
2)460
3)722
9)
2)463
3)726
2)492
3)752
12)
(Continued)
279
-------
TABLE A-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
52
Isophthalonitrile
53
Isopropyl ether
(propane ,2,2'-
oxybis)
060108203
(1Y&OY)
8470 rat
TDLo:800ppm/
5M/TFX:IRR,
ihl-hmn
LD50:812mg/kg,
ipr-mus
USOS air: TWA
500 ppm
54
Lactic acid
000050215
(QYVQ)
3730 rat
4875 mus
1810gpg
LDLo:50 mg/kg,
orl-hmn
LDLo:471 mg/kg,
idu-hmn
LD50:4500 mg/kg,
skn-mus
55
Lawroyl peroxide
000105748
Highly irr to skn,
eye, mu mem
TDLo:38gm/kg/
63WI
TFX:NEO, skn-mus
TDLo:330 mg/kg/
82W
TFX:NEO, scu-mus
56
Lead naphthenate
(naphthenic acid,
lead salt)
5100 rat
LD50:520 mg/kg,
skn-rat
57
Melamine
000108781 LDLo:1600
mus
Irr, causes derma-
titis
LD50:4328 mg/kg,
ipr-rat
58
Methionine, L-
000063683
Nutrient
59
Methyl acrylate
000096333 300 rat
LDLo:280
(1U1V01)
rbt
TCLo:75 ppm
TFXiIRR, ihl-hmn
LCLo: 1000 ppm/
4H, ihl-rat
LD50:1300 mg/kg,
skn-rbt
USOS air: TWA
10 ppm (skn)
60 Methyl-n-amyl ketone 000110430 1670 rat LCLo:4000 ppm/
(2-keptanone) (5V1) 730 mus 4H, ihl-rat
USOS air: TWA
100 ppm or
465 mg/m3
280
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
2)756
3)756
9)
2)513
3)762
2)515
3)764
5.3/1973 — 3)769
9)
53.9/1973 — 2)525
3)791
9)
2)549
3)801
9)
2)50
3)805
2)452
3)376
(Continued)
281
-------
TABLE A-2. (Continued)
Item
No.
61
Compound
Name and
Formula
Methyl bromide
Chem. Abstr.
Registry No.
(WLN)
000074839
(ED
Oral Toxicity,
LD5Q, mg/kg
100 rat
Toxicology
LDLo:50 mg/kg,
orl-hmn
TLV
USDS air: CL 20
ppm (skn)
Carcinogen
—
TCLo:35 ppm
TFX:CNS, ihl-hmn
TDLo: 8000 ppm
TFX:SKN, skn-hmn
LCLo:514ppm/6H,
ihl-rat
LCLo:300ppm/9H,
ihl-gpg
62 Methylene diisocyanate
(MDI), (p,p1-diphenyl-
methane diisocyanate)
Methylenebis-4-
phenylisocyanate
TCLo:0.13 ppm/
30M
TFX:ALR, ihl-hmn
LD50:17 mg/kg,
ipr-mus
USDS: air C
0.02 ppm
63
Methyl ionone
64 Methyl
methacrylate
(2665)
000080626
(1UYV01)
8000 rat
6300 gpg
LDLo:5000
dog
LDLo:5000 mg/kg,
orl-hmn
TCLo:125ppm
TFX:CNS, ihl-hmn
TCLo:150mg/m3
TFX:CNS, ihl-hmn
LD50:3750 ppm,
ihl-rat
USDS air: TWA
100 ppm or
410mg/m3
65
Methyl salicylate
000119368
(QR BV01)
887 rat
2100 dog
1060gpg
LDLo: 170 mg/kg,
orl-hmn
LDLo: 1500 mg/kg,
scu-gpg
TDLo:500 mg/kg
(D preg)
TFX:TER,scu-rat
66
Oxalic acid
000144627
(QVVQ)
LDLo: 1000
mg/kg, dog
LDLo: 0.071 mg/kg,
orl-hmn
2)609
LDLo: 100 mg/kg,
orl-hmn
3)880
USDS air: TWA
1 mg/m3
67 Paraformaldehyde
(mistakenly listed
as s-trixane or
cyclic sym-trioxane
in ref 2)
— 800 rat
LDLo:10,000 mg/kg,
skn-rbt
68
Peracetic acid, 40%
(Peroxyacetic acid)
000079210
(QOV1)
1540 rat
10 gpg
LDLo:50 mg/kg, —
orl-hmn
LD50: 1410 mg/kg,
sk n-rht
282
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
2)535
3)810
2)537
3)820
Emission factors: — 398/1973 — 2)534
acetone-111.9, 3)825
HCN - 6.8, methyl 12)
methacrylate - 3.6,
hydroquinone - 0.5
2)849
3)832
2)609
3)880
2)934
3)885
2)626
3)891
(Continued)
283
-------
TABLE A-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
69 2-pentanone
(methyl propyl
ketone)
000107879
(3V1)
3730 rat LC50:2000 ppm/4H USOS air: TWA
ihl-rat 200 ppm or
700 mg/m3
70
Piperidine
0001,10894 400 rat
(T6MTJ)
LCLo:4000ppm/4H
ihl-rat
LD50:320 mg/kg,
skn-rbt
71
Propyl acrylate
72 Propylene carbonate
29,000 rat No orl toxicity
73
Salicylaldehyde
000090028
(VHR BQ)
LDLo: 1000 mg/kg,
scu-rat
74 Stearic acid
000057114
(QV17)
LD50:22 mg/kg,
ivn-rat
LD50:23 mg/kg,
ivn-mus
LDLo:5 mg/kg,
ivn-cat
75 Sorbitol
003959533
(Q1YQYQYQ
YQY1Q)
Low toxicity
76 Stilbene
Low ihl & orl
toxicity
77 Tannic acid
(3270)
001401554
500 rbt
LDLo: 2000
mg/kg, mus
LDLo:500 mg/kg,
orl-hmn
LDLo:75 mg/kg,
scu-mus
LDLo: 10 mg/kg,
ivn-mus
TDLo:4450 mg/kg/
17WI
TFX:CAR, scu-rat
78 Terephthalonitrile
(p-Dicyanobenzene)
000623267
(NCR DCN)
LD50:699 mg/kg,
ipr-mus
79 Tetraethyleneglycol
000112607 29,000 rat
(Q2020202Q)
No orl toxicity
284
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
2)621
3)890
2)721
3)917
3)942
2.2/1973 — 2)846
3)962
9)
2)871
3)994
72.0/1973 — 3)992
9)
3)624
2)887
3)1007
12)
3)568
5.5/1973 — 2)890
3)1014
9)
(Continued)
285
-------
TABLE A-2. (Continued)
Item
No.
80
Compound
Name and
Formula
Tetrahydrofuran
(Furan, tetrahydro)
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5o- m9/k9 Toxicology
000109999 3000 rat LDLo:50 mg/kg.
(T50TJ) orl-hmn
TCLo:25,OOOppm
TFX:CNS, ihl-hmn
LD50:500 mg/kg.
ipr-rat
TLV
USOS air: TWA
200 ppm or
590 mg/m3
Carcinogen
81 2,4-toluene-diisocyanate
(benzene, 2,4-
(3354) d i isocy anate-1-methy I)
6170 rat LDLo:5000 mg/kg, USOS air: CL
orl-hmn 0.02 ppm or
TCLo:0.02 ppm/2Y 0.14 mg/m3
TFX:PUL, ihl-hmn NIOSH rec'd
TDLo:0.5 ppm std
TFX:IRR, ihl-hmn Air: TWA
LC50:14ppm/4H, 5 ppb
ihl-rat
LC50:8 ppm/4H,
ihl-rbt
82 1,1,1-trichloroethane
(Methyl chloroform)
(3395)
000071556
(GXGG)
750 dog
5600 rbt
14,300 rat
LDLo:500 mg/kg,
orl-hmn
TCLo:350ppm
TFX:PSY, ihl-man
TCLo:920 ppm/
70MTFX:CNS,
ihl-hmn
LCLo:27,000 mg/m3/
10M, ihl-man
LCLo:1000 ppm,
ihl-rat
USOS air: TWA
350 ppm or
1900mg/m3
83 2,4,6-trichlorophenol 000088062 820 rat
(GR BG
DG FG)
LDLo:500mg/kg,
orl-hmn
LD50:276 mg/kg,
ipr-rat
TDLo:29gm/kg,
78WI
TFX:CAR
84 Tricresylphosphate
(phosphoric acid,
tritolyl ester)
001330785
3000 rat
LDLo:4680
rat
LDLo: 500
dog
LDLo: 100
rbt
LDLo: 1000 mg/kg,
orl-hmn
TDLo:6 mg/kg
TFX:CNS, orl-hmn
85
Triethyleneglycol
monoethyl ether
(Dowanol TE)
000112505
(Q2020202)
86 Triethyleneglycol
monomethyl ether
(Methoxytriglycol)
11, 000 rat
1.050:7100 mg/kg,
skn-rbt
286
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
— — — 2)435
3)1016
Emission factors: — — — 2)159
hyd rocarbons - 14.0 3)1037
12)
2)398
3)1044
12)
2)649
3)1046
2)676
3)1048
10.6/1973 — 9)
13.2/1973 — 3)805
9)
(Continued)
287
-------
TABLE A-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
87
Triethylenetetramine
000112243 4340 rat
(Z2M2M2Z)
LD50:820 mg/kg,
skn-rbt
88
s-trioxane
(formaldehyde
cyclic trimer)
000110883 800 rat
(T60 CO E)
TJ)
LDLo:50 mg/kg,
orl-hmn
LDLo: 10,000 mg/kg,
skn-rbt
89 Trimethylol propane
90 Triphenylphosphate 000115866 3000 rat
(ROPO&OR
&OR)
LDLo:50 mg/kg,
orl-hmn
LD50:100 mg/kg,
scu-cat
91 2-vinyl pyridine
Skn, eye, muc mem
irr
See pyridine
92
Xylylene
diisocyanate
(m-Xylene -
diiocyanate)
4960 rat
288
-------
Process
(Sources Process
of Compound) No. Associated Wastes
__
Total
Waste Production
Treatment 1 06 kg/year
Uses References
2)933
3)1052
9)
2)934
3)1066
2)676
3)1068
3)1089
2)960
289
-------
TABLE A-3. INDUSTRIAL ORGANIC CHEMICALS,
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
1 Aluminum chloride
DP
007446700 3700 rat
(ALGe)
3805 mus
2 Aluminum hydroxide
AI(OH)3
012645512
3 Ammonia
DP NH3
007664417 350 rat
(ZH)
LCLo:10,000 ppm/
3H, ihl-hmn
TCLo:20 ppm
TFX:IRR, ihl-hmn
Irr to eyes & mucous
mem of respiratory
track
USDS air: TWA
50 ppm
4 Ammonium carbonate
96 ivn-mus
5 Ammonium chloride
DP NH4CI
012125029 1650 rat
(Z&G)
Nausea, vomiting,
anc' ac'clos's
Air: TWA 10mg/m3
6 Ammonium sulfate
(NH4)2SO4
007783202 58 rat
(Z&2 S-04)
7 Boron trif luoride
BF3
007637072
(FBFF)
LCLo:75 ppm,
ihl-rat
Corrosive to skn, irr
to eyes & mucous mem
USDS air: CL 1 ppm
8 Bromine
DP Br2
007726956
(E2)
LCLo:180ppm/7H,
ihl-rbt. Irr to eyes
& upper respiratory
track; pulmonary
edema
USOSair: TWA 0.1
ppm
9 Clacium carbonate
DP CaC03
001317653 4500 rat
10 Calcium chloride
DP CaCl2
010043524 1000 rat
(Ref 2)
4000 rat
{Ref 4)
(CAG2)
11 Calcium hydroxide
Ca(OH)2
001305620 7340 rat
Caustic reaction;
skn irr; affects
respiratory system
12 Calcium oxide
DP CaO
001305788
USOS air: TWA
290
-------
INORGANICS-TOXICITY
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
2)58
3)374
61701A
2)70
3)386
6)702B
2)73
3)388
2)74
3)389
2)99
3)396
3)469
6)161
3)471
3)509
2)263
4)191
6)723
3)511
4)193
2)264
(Continued)
291
-------
TABLE A-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
12 Calcium oxide
DP CaO
001305788
USDS air; TWA
5
13 Carbon dioxide
DP CO2
000124389
TDLo:6pph/100
preg,TFX:TER,
ihl-rat
Simple asphyxiant
USOSair: TWA
5000 ppm
14 Carbon monoxide
CO
000630080
(CO)
LCLo:4000ppm/30
M, ihl-man
TCLo:650 ppm/45
M,TFX:CNS, ihl-man
Asphyxia; deprives
tissue of oxygen by
reaction in blood
USOSair: TWA
50 ppm
15 Chlorine
DP Cl2
007782505
(G2)
TCLo:15 ppm,
TFX:PUL, ihl-hmn
LCLo:430ppm/30M,
ihl-hmn
Irr to eyes & mucous
mem; lung tissue is
affected; pulmonary
edema
USDS air: TWA
1 ppm
16 Copper su If ate
DP CuSO4
007758987
(CU S-04)
300 rat
USOSair: TWA
1 mg/m3 (as Cu)
17 Cuprous chloride
DP Cu2CI2
18 Cuprous oxide
001317391
USOSair: ?
19 Ferric chloride
FeCI3
007705080 900 rat
(FEGe) 440mus
Air: TWA 1 mg/m3
20 Ferrous sulfate
(Iron (11) sulfate)
FeSO4
007720787 1480 rat
1170 mus
LDLo:50
chd
(FE S-04)
TOLo: 1600 mg/kg/
16WC,TFX:NEO.
scu-mus
21 Hydrochlorousacid
HCIO
007790923 —
22 Hydrogen
H2
001333740
Simple asphyxiant
in high concn
292
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
2)264
2)293
3)519
61727A
2)295
3)520
2)307
3)539
6)728A
2)345
6)7336
2)345
2)553
3)765
2)648
6I734B
4)544
(Continued)
293
-------
TABLE A-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD&0, mg/kg
Toxicology
TLV
Carcinogen
23 Hydrogen bromide
HBr
010035106
TCLo:5 ppm,
TFX:IRR. ihl-hmn
Strong irr to mucous
mem, eyes, respira-
tory tract, skn
USDS air: TWA
3 ppm
24 Hydrogen chloride
HCI
007647010 900 rbt
(GH)
LCLo:1300ppm/30M, USDS air: CL
ihl-hmn 5 ppm
Irr to eyes & upper
respiratory tract;
pulmonary edema
25 Hydrogen fluoride
HF
007664393 LDLo:80
(FH)
gpg
TCLo:32 ppm,
TFX:IRR, ihl-hmn
TCLo:110 ppm/1M,
TFX:IRR,ihl-man
Irr to skn &
mucous mem
USDS air: TWA
3 ppm
26 Hydrogen peroxide
H202
007722841
Irr to body tissue,
skn blistering; eye
USDS air: TWA
1 ppm
27 Iron oxide
(Iron III oxide)
001309371
28 Lithium phosphate
Li3P04
021324403
29 Manganese acetate
(Manganese, bis
(acetato)-)
021501768
Chronic poisoning
affects CNS; may
result in permanent
disability; upper
respiratory
infection
30 Meta boric acid
(Boric acid)
HBO2
(Boric acid)
H3B3Oe
013460509 —
31 Nitric acid
HN03
007697372
USDS air: TWA
2 ppm
32 Nitrogen
N2
017778880
Nontoxic generally;
simple asphyxiant
in high concn
294
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
— — — 2)619
31815
2)619
3)816
6) 729A
2)610
3)817
6)7356
2)621
3)818
6)7386
3)769
3)885
2)795
3)961
6)7376
3)967
4)738
(Continued)
295
-------
TABLE A 3 'Continued!
Compound
Item Name and
No Formula
33 Nitrogen dioxide
Chem. ACstr.
Registry No.
(WLN)
010102440
(ONOl
Oral Toxicity,
LD50/mg/kg Toxicology TLV Carcinogen
— TCLo:64ppm, USDS air: TWA —
TFX:PUL, ihl-hmn 5 ppm
Highly toxic;
deadly poison;
inflammation of
the lungs, edema.
& death
34 Nitrosyl sulfuric acid
INitrosyl suifate)
NO2HSO3
007782787
35 Oxygen
02
007782447
Nontoxic as a gas;
causes burns as a
liquid, dam ages
tissue on contact
with skn
36 Phosphates
014265442 —
37 Phosphoric acid
H3P04
007664382 1530 rat
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10® kg/year Uses References
— — — — — 2)798
3)967
4)739
3)975
3)989
2)897
3)1022
4)324
3)1026
2)951
3)1042
4)853
2)951
4)853
2)1062
(Continued)
297
-------
TABLE A-3. (Continued)
Item
No.
44
Compound
Name and
Formula
Sodium bromide
NaBr
Chem. Abstr.
Registry No.
(WLN)
007647156
(NA E)
Oral Toxicity,
LDg-, mg/kg Toxicology
3500 rat
TLV Carcinogen
—
45 Sodium carbonate
DP Na2C03
000497198 LDLo:4000
(QVQ &-NA-2)
rat
117 ipr-mus. Sensi-
tivity reactions
occur from repeated
topical use; ing may
produce corrosion
of the GI tract,
vomiting, &
diarrhea
46 Sodium chloride
DP NaCI
007647145
(NAG)
3000 rat
4000 mus
TDLo:8200
mg/kg/23D,
TFX:BPR,
hmn
Irr to eyes
47 Sodium cyanide
DP NaCN
000143339
(NC -NA-)
6400 rat
Very poisonous.
Toxicity is
similar to
hydrogen cyanide
USOS air: TWA
5 mg/m3 (skn)
48 Sodium dichromate
DP (Dichromic acid,
disodium salt)
010588019
(NA CR2-05-
Q2)
Caustic and irr
USOS air: CL
100 M9/m3
TDLo: 160 mg/kg/
69WI,TFX:NEO,
ipr-rat
49 Sodium hydrosulfide
NaSH
016721805
50 Sodium hydroxide
DP NaOH
001310732
(NAQ)
LDLo:500
rbt
400 ipr-mus
Corrosive to body
tissue, vegetable
tissue, & corrosive
to aluminum metal
in the presences of
moisture. Damage
to respiratory tract.
USOS air: TWA
2 mg/m3
51 Sodium perborate
007632044
52 Sodium sulfate
007757826
(NA2 S-02-Q2)
LDLo: 4470 rbt
298
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
2)1062
4)955
— — — — 2)1062
3)1105
6)730B
2)1062
3)1106
2)1063
3)1107
2)413
3)1107
6)733A
8)129
7)759B
2)1065
3)1111
4)960
6)730A
2)1070
6)760
(Continued)
299
-------
TABLE A-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
UD, mg/kg
Toxicology
TLV
Carcinogen
53 Sodium sulf ide
DP Na2S
001313822
53 ipr-mus
54 Sodium sulfite
N32SO3
00757837
TDLo:57TFX:
UNK. orl-hmn
TDLo:7TFX:
CNS, orl-hmn
LDI_o:1181
orl-rbt
55 Sulfur dioxide
SO2
007446095
(050)
TCLo:3 ppm/5D,
TFX:PUL, ihl-hmn
TDLo:10ppm/5M,
TFX:PUL, ihl-man
Irr to eyes; corrosive;
poison; edema of
the lungs; respira-
tory paralysis;
excessive exposure
can be fatal
USOS air: TWA
5 ppm or 13 mg/
56 Sulfuric acid
DP H2SO4
007664939
(WSQQ)
2140 rat TCLo:800 g/m3,
TFX:MTH, ihl-hmn
TCLo:350 g/m3/
3M,TFX:PUL, ihl-
hmn. Burns; caustic;
nicrotis. Corrosive
to all body tissues;
ihl may cause
serious lung damage;
contact with eyes
may cause total
loss of vision; ing
may cause serious
inury and death
USOS air: TWA
1 mg/m3
57
Sulfur trioxide
S03
007446119
Corrosive and irr
to mucous mem
300
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
2)1070
6)763
2)1070
6)763
2)1096
3)1133
2)1096
3)1134
6)776
3)1136
4)1006
(Continued)
301
-------
TABLE B-1. ORGANIC DYES AND PIGMENTS, RAW MATERIALS-TOXICITY
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
Alkyl thioureas
di-t-Amylphenol
000120956 330 rat
See phenol
Antimony potassium
tartrate
000304610
(QVYQYQ
VO-SB-O&
-KA-)
115 rat
600 mus
LDLo:2 mg/kg,
orl-hmn
LD50:50 mg/kg
skn 8 ivn-mus
USDS air: TWA
0.5 mg/m3 (as
Sb)
Carbazole
000086748 500 rat
(T B656
HMJ)
Allergen, toxi-
city unknown
LD50:200 mg/kg,
ipr-mus
5 Cellulose Waste
6 p-Chlorobenzenesul-
fonic acid
4-Chloro-3-
nitrobenzoic acid
000096991
75bdw
3150 rat
p-Chloro- a, a, a-
trifluorotoluene
(p-chlorobenzotri-
fluoride)
Slightly toxic
Cyclohexyl alcohol
000108930
(L6TJAQ)
2060 rat
2200 rbt
LDLo:500 mg/kg,
orl-hmn
TCLo:75 ppm
TFX:IRR, ihl-hmn
causes kidney,
liver, bid damage
USDS air: TWA
50 ppm
USDS air: TWA
200 mg/m3
10
2,4-Diaminotoluene
000095807
(ZR CZ D)
LDLo:500
rat
LDLo:50 mg/kg,
orl-hmn
LDLo:200 mg/kg,
scu-dog
Causes kidney
damage. Allergen.
TDLo:11 gm/kg/
36WC,TFX:CAR
orl-rat
11
Dimethylamine
000124403
(1M1)
698 rat
316 mus
240 rbt
USDS air: TWA
10 ppm
USDS air: TWA
18 mg/m3
12
p-Dodecyl aniline
302
-------
PROCESS, WASTE, PRODUCTION AND USE DATA
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10® kg/year
Uses
References
2)645
2)106
3)384
2)279
3)468
2)188
3)489
2)326
3)529
2)914
3)1035
2)367
3)595
(Continued)
303
-------
TABLE B-1. (Continued)
Compound
Item Name and
No. Formula
Chem, Abstr.
Registry No. Oral Toxicity,
(WLN) LD,-n, mg/kg
Toxicology
TLV
Carcinogen
13
Glucose (corn
sugar), D
000050997 25,800 rat
8,000 dog
20,000 rbt
14
Hematin
15
Hydrazine
000030212 60 rat
(ZQ)
High toxicity orl,
skn, & ivn. Causes
liver & bid damage
LC50:570ppm/
4H, ihl-rat
LD50:20 mg/kg,
ivn-rbt
USOS air: TWA
1 ppm
USOS air: TWA
1.3 mg/m3
TDLo:400 mg/kg/
5WI,TFX:CAR
ipr-mus
TDLo:410 mg/kg/
26WC
TFX:CAR,orl-mus
16 3-Hydroxybenzenesul-
fonic acid
17 4-Hydroxybenzenesul-
fonic acid
Details unknown, less
toxic than phenol
18 p-Hydroxybenzoic acid 000099967 2200 mus
(QVR DO)
LD50:210 mg/kg,
ipr-mus
19 Logwood extracts
20
Mesitylene
000108678
(1RCE)
TCLo:10ppm
TFX:CNS ihl-hmn
LDLo:2240ppm/
24H, ihl-rat
USOS air: TWA
25 ppm
21 Methanesulfonic acid 000075752 LDLo:200
(WSQ1)
rat
Highly irr skn, eye,
mu mem
LDLo:50 mg/kg,
ipr-rat
22 Methyl isopropyl
ketone
(2-Butanone-3-methyl)
000563804 148 rat
(1YY1)
LCLo: 5700 ppm/
4H, ihl-rat
23
Methyl mercaptan
000074931
(SH1)
LD50:2.4 mg/kg, USOS air: TWA
scu-mus 0.5 ppm
LD Lo: 10,000 ppm, USOS air: TWA
ihl-rat 1 mg/m^
24 p-Nitrobenzoyl
chloride
Highly irr skn, eye,
muc mem. Details unk.
304
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
— — — — — — 2)440
2)463
3)726
3)898
2)192
2)533
3)799
2)538
3)801
2)243
2)539
3)824
3)857
(Continued)
305
-------
TABLE B-1. (Continued)
Compound
Item Name and
No. Formula
26 i-Propylamine
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
25 Oxalic acid
000144627
(QVVQ)
LDLo:1000
dog
LDLo: 100 mg/kg.
orl-hmn
LDLo:112 mg/kg.
scu-cat
USDS air: TWA
1 mg/m3
27 Pyrene
000129000
(L666B6
2AB PJ)
TDLo:10gm/kg/
3WI,TFX:NEO
skn-mus
28 Quebracho extract
(Quebrachine)
000146485
(T F6 05
C666 EM
ON &&
TTTJTQ
UV01
A&TU)
LDLo: 25
mus
LDLo:11 mg/kg,
ivn-rbt
LD50:34 mg/kg,
scu-frg
29
Thiourea
000062566
(ZVZUS)
125 rat
11,500 mus
TO Lo: 1600 mg/kg/
5W,TFX:BLD,orl-
wmn
Highly toxic. Causes
anemia & skn
allergy
TDLo:18gm/kg/
2YC, TFX:NEO
orl-rat
30
Toluene
000108883 5000 rat
LDLo:50 mg/kg,
orl-hmn
TCLo:200 ppm
TFX:CNSihl-hmn
TCLo:100ppm
TFX:PSY ihl-man
LC 50:5300 ppm
ihl-mus
USOS air: TWA
200 ppm or 750
mg/m2
NIOSH rec. std.:
TWA 100 ppm,
C200ppm/10M
31 o-Toluenesulfonic acid —
High irr skn, eye,
muc mem, orl, ihl
32 Trimellitic anhydride 000552307 2210 mus
(T56 BVOVJ
GVQ)
Highly toxic. Has
caused pulmonary
edema. Alergen.
306
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10*> kg/year Uses References
2)609
3)880
2)794
3)947
2)1204
3)1097
2)953
3)1030
3400/1974 — 2)913
4204/1978 3)1035
3)1036
2)166
3)1058
307
-------
TABLE B-2. ORGANIC DYES AND PIGMENTS' INTERMEDIATES-TOXICITY,
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
1 Acetamide, N-(3-amino- 017026812 — —
4-ethoxy phenol)-
2 Acetamide, N-(4-amino- 000119631 30 rat Mild irritant, low
phenyl)-N-methyl- toxicology
3 Acetamide, N-(4-bromo- — — —
9,10-dihydro-9,10-
dioxo-1-anthracenyl)-
4 Acetamide, 2-chloro-N- 017329872 — —
(4-nitrophenyO-
Acetamide, N-(7-
hydroxy-1-
naphthalenyl)-
006470184
Acetamide, N-(4-
hydroxy-2-
nitrophenyl)-
007403750
7 Acetamide, N-methyl- —
N-[4-p_-toluidino-1-
anthraquinonyl] -
8 Acetamide, N-[2'-nitro- —
3'-(7H-benz[de]
anthracen-7-one] -
9 Acetamide,N-(7-oxo-7H- 053652258
benz[de] anthracen-3-yl)-
yl)-
10
Acetanilide
000103844 800 rat
(1VMR)
LDLo:1000 mg/kg,
ipr-mus
11 Acetanilide, 3'-amino- 000102283 1830 rat
12 Acetanilide, 4'-amino- 000122805 3350 rat
(ZR DMV1)
13 Acetanilide,3'-[bis-(2- 027059081
hydroxyethyDamino] -
14 Acetanilide, 2'-chloro- 000533175
(GR BMV1)
(a) Process number = Figure number, page number (reference 15).
308
-------
PROCESS, WASTE, PRODUCTION AND USE DATA
Process Total
(Sources Process'3' Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year
Uses
References
Reduction 9c, 29
2c, 18
3)349
343, 56
7d,23
23b, 35
27,47
34e,56
34c,54
34c, 54
2a, 16
1.691/1974
2)9
3)349
25c, 45
2a, 16
2)9
2)9
25c, 45
7d,23
2)9
(Continued)
309
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
15 Acetanilide, N-2-cyanoethyl-
(See Propionitrile, 3-(N-acetanilino)-
16
Acetanilide, 2',4'-
dichloro-
006975297
17
Acetanilide, 2',5'-
dimethoxy-
003467592
18 Acetanilide, 2',5'
dimethoxy-4'-nitro-
025445130
19
Acetanilide, 2',4'-
dinitro
000610537
20
Acetanilide, 4'-
hydroxy-
000103902 2400 rat
(QR DMV1)
LDLo: 3700 mg/kg,
ivn-rbt
21 Acetanilide, N-methyl- 000579102 155 mus LDLo: 125 mg/kg,
(1VN1&RI ipl"mus
VN&R)
22 Acetanilide, N-methyl- 000121959
4'-nitro-
23 Acetanilide, 2'-nitro- 000552399
24 Acetanilide, 3'-nitro- 000122281
25 Acetanilide, 4'-nitro- 000104041
(WNR DMV1)
LDLo:500 mg/kg,
ipr-rat
26 o-Acetanisidide
000093265 940 mus
27 p-Acetanisidide
000051661 1190 mus
(1VMR DO1)
28 p-Acetanisidide, 2'
nitro-
000119813
29
o-Acetanisidide, 4'-
nitro-
000093276
30
o-Acetanisidide, 5'-
nitro-
033721549
310
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
2a, 16
19,33
19,33
7e, 24
27,47 — — — — 2)11
2c, 18 — — — — 2)11
2c, 18
2a, 16
25c, 45
2a, 16 — — — — 2)11
7c, 22 — — — — 2)12
9a, 27 — — — — 2)12
9a, 27
7c, 22 —
7c, 22
311
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
31 Acetic acid, [4-(chloro- 000094768
o-tolyl-thio] -
32
Acetic acid, (2-
naphthyl-thio)-
000093210
33 Acetoacetanilide
000102012
(1V1VMR)
LDLo:300 mg/kg,
ipr-mus, weak allergen
34 Acetoacetanilide, 2'-
chloro-
000093709
35 Acetoacetanilide, 4'-
chloro-
000101928
(GR
DMV1V1)
LDLo:500 mg/kg,
ipr-mus
36 Acetoacetanilide, 4'- 004433798 —
chloro-2',5'-dimethoxy-
37 o-Acetoacetanisidide 000092159 —
38 p-Acetoacetophenetide 000122827 —
39 o_-Acetoacetotoluidide 000093685 —
40 p-Acetoacetotoluidide 002415852 —
41 o-Acetoacetotuluidide, 020139553
4'-chloro-
42 o-Acetoacetotuluidide, — —
4'-nitro-
43 2',4'-Acetoacetoxylidide 000097369 —
44 g-Acetophenetide 000062442 1650 rat
(ZORDMV1)
TDLo: 1000 mg/kg,
TFX:CNS
45 p-Acetophenetide, 3'- 021615292
[bis (2-hydroxyethyl)]
46 p-Acetophenetide,3'-[di
(2-acetoxyethyD-
amino] -
312
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
28,47
44,35
4, 16 — — — — 2)28
3)350
7d,23
— 9a,27 — — — — 2)28
19,33
7C<22
9c, 29
30,50
12,49
29b, 49
4,63
3)353
gc 29
9c,29
(Continued)
313
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD50/mg/kg
Toxicology
TLV
Carcinogen
47 j>Acetophenetide, 3'- 001777840 664 rat
nitro-
48 o-Acetotuluidide
025449096 1450mus
(1VMR B)
49
p-Acetotuluidide
000103899
Unknown
50
p-Acetotuluidide, 3'-
51
o-Acetotuluidide, 4'-
amino
52 £-Acetotoluidide, 3'-
chloro-
007149793
53 o-Acetotoluidide, 4'- 005202868
chloro-
54 ^-Acetotoluidide, 4'-
(N,N-diethylamino)-
55 j>Acetotoluidide, 3'-
nitro-
002719144
56 Aniline derivatives
(See also Benzenamine)
57 Aniline, 2-bromo-6-
chloro-4-nitro
58
Aniline, N-butyl-
001126789 1620 rat
(4MR)
59 Aniline, N-ri-butyl-N —
(2-chloroethyD-
60 Aniline, N-butyl-N-(2-
hydroxyethyl)-
See Ethanol, 2-[N-n-butylanilino)-
61
Aniline, m-chloro-
000108429
(2R CG)
880 rat
LDLo:310mg/kg,
scu-cat
314
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
9c, 29
2)31
29a,48
2)33
30, 50
Reduction 30,50
3)353
Reduction 29b, 49
12,50
29b, 49
29b, 49
30,50
12,29
2b, 17
2)106
2b, 17
25b, 44
2)106
(Continued)
315
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
62
Aniline, o-chloro-
000095512
(ZR BG)
256 mus
LDLo:310 mg/kg,
scu-cat
63
Aniline, p-chloro-
000106478 300 rat
(ZR DG)
TCLo:44 mg/m3
ihl-hmnTFX:BLD
64 Aniline, 4-chloro-2,5- 006358641 100 bdw
dimethoxy- (1OR BZ EG
D01)
65 Aniline, 5-chloro-2,4- 000097507
dimethoxy-
66 Aniline, 2-chloro-4,6- 003531199 —
dinitro-
67 Aniline, N-(2-
chlorethyl)-N-ethyl-
000092499
68 Aniline, N-(2- 001669858
chloroethyl)-N-methyl-
69
Aniline, 2-chloro-
4-nitro-
000121879
(ZR BG
DNW)
LDLo:500 mg/kg,
ipr-mus
70
Aniline, 2-chloro-
nitro-
006283256
71 Aniline, 4-chloro-2-
nitro-
000086634
(ZR DG
BNWZR
DOG BNW)
LD50:63 mg/kg.
72 Aniline, 4-chloro-3-
nitro-
000635223 100 bdw
73 Aniline, 2,6-dibromo- 000827411
4-nitro- (ZR DQ
CNW)
74 Aniline, 2,4-dichloro- 000554007 LDLo:157 mg/kg,
(ZRBGDG) orl'cat
316
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
45,23 — — — — 2)106
9a,27 — — — — 2)106
19,33 — — — — 2)106
40,63
12,24
2b, 17
6, 18
7d,23 — — — — 2)106
7e, 24
9c, 29 — — — — 2)106
18,32
7e, 24
9a, 27
12,16
2a, 16 — — — — 2)107
25b,44
(Continued)
317
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
75 Aniline, 2,5-dichloro- 000095829
76 Aniline, 3,4-dichloro- 000095761 648 rat
(ZR CG DG)
TCLo:25 g/m3
ihl-hmnTFX:EYE
77 Aniline, 2,6-dichloro-
4-nitro-
006627345
(ZR BG FG
DNW)
1500 rat LD Lo: 1500 mg/kg,
orl-rat
78 Aniline, 2,5-diethoxy- 000094859
79 Aniline, N,N-diethyl- 000091667
80 Aniline, N-N-diethyl-p- 000120229
nitroso-
81 Aniline, 2,5-dimethoxy- 000102567 100 bdw
(1OR BZ
D01)
82 Aniline, 2,5-dimethoxy- 006313377
4-nitro-
83 Aniline, N,N-dimethyl- 000121697 LDLo:1410 LD50:1770 mg/kg, USOS air: TWA
(1N1 &R) mg/kg, rat skn-rbt 5 ppm (skn)
84 Aniline, N,N-dimethyl- 000138896 65 rat
-B-nitros°- (OMR DN1
&1)
TDLo: 7300 mg/kg/
1Y, TFX:NEO,
orl-rat
85 Aniline, 2,4-dinitro- 000097029 418 rat
(WNR BZ
ENW)
LDLo:250 mg/kg,
ipr-rat
86
87
Aniline, N-ethyl-
000103695
Aniline, N-ethyl-N-
(2-hydroxyethyD-
(See Ethanol, 2-(N-ethylanilino)-
88 Aniline, N-(2-
hydroxyethyl)-N-methyl-
(See Ethanol, 2-(N-methylanilino)-
318
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
45,32
9c, 29
2)107
12,29
2)107
19,33
6,8,10,17
2b, 17
1.495/1974
20,33
2)107
19,33
6,7,8,
10 18
8.803/1974
2)107
2c, 18
2)108
7e, 24
0.261/1974
2)109
2b, 17
1.088/1974
319
(Continued)
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
89 Aniline, 2-hydroxy-
5-methyl-
90 Aniline, 2-methoxy-
5-methyl-
001207181
91 Aniline, 2-methoxy-
6-methyl-
050868730
92 Aniline, 4-methoxy-
3-nitro-N-phenyl-
93 Aniline, N-methyl-
000100618 LDLo:280 mg/kg,
(1MR) or'-rbt
USDS air: TWA
2 ppm (skn)
94 Aniline, 4,4'-
methylenebis-[N,N-
diethyl-
000135911
95 Aniline, 4,4'-
methylenebis-[N,N-
dimethyl-
028213812 681 rat
(1N1&R
D-21)
96 Aniline, m-nitro-
000099092 535 rat
(ZR CNW)
LDLo:70 mg/kg,
ipr-dog
97 Aniline, o-nitro
000088744 535 rat
(ZR BNW)
98 Aniline, £-nitro-
0001000016 3249 rat
(ZR DNW)
LDLo:40 mg/kg,
ivn-mam
USDS air: TWA
1 ppm (skn)
99 Aniline sulfonic acid,
ethylbenzyl
(See m-Toluenesulfonic acid, -(N-ethylanilino)-)
100 Aniline, 2,4,5-
trichloro-
000636306
101 o-Anisicacid
000579759
Unknown pro-
bably low
320
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Reduction
15,31
Reduction
15,31
Reduction
14,31
18,32
2c, 18
2)110
6,7,17
2c, 18
0.844/1974
2)110
25c, 45
2)111
2a, 16 Emission factors:
7d,23 NH3-3.0,
nitrobenzene -1.0,
NO2- 1.0,
SO2- 1.0
2)111
12)
2a, 16 Emission factors:
9c, 29 same as o-
nitoaniline
2)111
12)
40,63
36,60
3)410
(Continued)
321
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
102 p-Anisic acid
0001000094
Unknown
probably low
103 m-Anisidine
104 o-Anisidine
000536903
000090040
USOS air: TWA
0.1 ppm (skn)
USOS air: TWA
0.5 mg/m3 (skn)
105 p-Anisidine
000104949 1400 rat
(ZR D01)
USOS air: TWA
0.1 ppm (skn)
USOS air: TWA
0.5 mg/m3 (skn)
106 £-Anisidine, 4-jv
butylsulfonamido-
(See Benzenesulfonamide, 3-amino-N-ri-butyl-4-methoxy-)
107 o-Anisidine, 4-chloro 000093505 —
108 o-Anisidine, 5-chloro- 000095034 —
109 p-Anisidine, 2-nitro- 000096968 —
110 p-Anisidine, 3-nitro- 000577720 —
111 o-Anisidine, 4-nitro- 000097529
112 c>-Anisidine, 5-nitro- 000099592 704 rat
(WNR CZ
DO1)
113 c>-Anisidine, 5-nitro- —
N-ethyl-
114 p-Anisidine, 3-nitro-
N-phenyl-
115 Anisole, 4-anilino-
2-nitro-
(See Aniline, 4-methoxy-3-nitro-N-phenyl-)
116 Anisole, 5-jv
butylsulfonamido-2-
nitroanisole-
(See Benzenesulfonamide, N-n-butyl-4-methoxy-3-nitro)
322
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
21,34 — — — — 3)410
25e, 45
7c, 22 — — — — 2)113
3)410, 16
9a, 27 — — — — 2)113
3)410, 16
25b,44
18,32
9a, 27
7c,22 —
7c, 22 — — — — 2)113
7e, 24
18,32
323
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
117 Anisole, 4-chloro-2-
nitro-
000089214
118 Anisole, 2,4-diamino-
(See m-phenylenediamine, 4-methoxy-)
119 Anisole, 4,5-dichloro-
2-nitro-
(See Benzene, 1,2-dichloro-4-methoxy-5-nitro)
120 Anisole, 2,4-dinitro- 000119277 LDLo:100
(WNR BO1 rat
ENW)
121 Anisole, m-methyl-
000100845
122 Anisole, m-nitro-
000555033
123 Anisole, o-nitro-
000091236
124 Anisole, £-nitro- 000100174 4700 mam
125 p-Anisoyl chloride 000100072 —
126 p-Anisoyl chloride, 010397281
3-nitro-
127 2-Anthracenecarboxylic 000135477
acid, 3-chloro-
128 2-Anthracenecarboxylic —
acid, 3-chloro-9,10-
dihydro-9,10-dioxo-
129 2-Anthracenecarboxylic 006295449
acid, 3-hydroxy-
130 9,10-Anthracenedione 000084651
(L C666 BV
IVJ)
TDLo:90gm/kg/
90DC
TFX:NEOorl-rat
131 9,10-Anthracenedione, 000082451 —
2-amino- (LC666BV
IVJ D2)
TDLo:2440 mg/kg/
61WI
TFXiNEO
324
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
18,32 — — —
7e, 24 — — — — 2)167
14,31
25c. 45
7c, 22
9a,27
21,34 — — — — 3)410
23a, 34 —
— 34b, 53
34b, 53
346,53
34g, 58
34e,52 — — — — 2)116
34c, 54 — — 0.318/1974 — 2)116
34e, 56
(Continued
325
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgg, mg/kg Toxicology TLV Carcinogen
132 9,10-Anthracenedione, 000117793
2-amino-
133 9,10-Anthracenedione, 034037462 — — — —
1 -amino-2-bromo-4-
jj-toluidino-
134 9,10-Anthracenedione, 000117077
1-amino-2-chloro
135 9,10-Anthracenedione, 000117113 — — — —
1-amino-5-chloro-
136 9,10-Anthracenedione, 000117099 — — — —
1-amino-8-chloro-
137 9,10-Anthracenedione, 000084468 — — — —
2-amino-3-chloro-
138 9,10-Anthracenedione, 002478673 — — —
1 -am ino-2-ch loro-4-
hydroxy-
139 9,10-Anthracenedione, 000081492 — — — —
1-amino-2,4-dibromo-
140 9,10-Anthracenedione, 006374761 — — — —
2-amino-1,3-dichloro-
141 9,10-Anthracenedione, 013432321 — — — —
1-amino-2,4-dichloro-
142 9,10-Anthracenedione, 000081516 — — —
1 -amino-2,4-dihydroxy-
143 9,10-Anthracenedione, 000117771
2-amino-3-hydroxy-
144 9,10-Anthracenedione, 000082280 — — — —
1-amino-2-methyl-
145 9,10-Anthracenedione, 006937742 — — — —
1-amino-4-nitro-
146 9,10-Anthrac3nedione, — — — — —
1-amino-5-nitro-
326
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
28,58
15,28,59
34a, 52
28,55
34,55
28,52
34h, 59
12,59 — — 0.389/1974
12,58
12,59
28,58
36,52 —
34b,53
28,56,59 — — — — —
28,54
(Continued]
327
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) '-'•'
so'
Toxicology
TLV
Carcinogen
147 9,10-Anthracenedione, 000632837 —
1 -bromo-
148 9,10-Anthracenedione, —
1 -bromo-4-hydroxy-
149 9,10-Anthracenedione, 000128938
1 -bromo-4-methy lamino-
150 9,10-Anthracenedione, 000082440
1-chloro-
151 9,10-Anthracenedione, 000131099
2-chloro-
152 9,10-Anthracenedione, 000082428
1 -chloro-4-hydroxy-
153 9,10-Anthracenedione, 000129351
1 -chloro-2-methy I-
154 9,10-Anthracenedione, 006337822
1-chloro-4-nitro-
155 9,10-Anthracenedione, 000129408
1-chloro-5-nitro-
156 9,10-Anthracenedione, 000129384
1-chloro-8-nitro-
157 9,10-Anthracenedione, 000129442
1,5-diamino-
158 9,10-Anthracenedione, 000129420
1,8-diamino-
159 9,10-Anthracenedione, 000145493
1,5-diamino-4,8- (L C666 BV
dihydroxy- IVJ DZ GQ
KZNQ)
LDLo:256 mg/kg,
ipr-mus
160 9,10-Anthracenedione, 001594463
1,2-dichloro-
161 9,10-Anthracenedione, 000082462
1,5-dichloro-
328
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
34e,56
12,57
12,56
28,56
28,58
12,57
25,53
— 34e, 56
_^ j^u, 5S ^— ___ ^_ __
34d, 55
— 28,32,54,55
34c,54
— 34d,55 — — — — 2)115
34a,52
34d, 55
(Continued)
329
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q'
Toxicology
TLV
Carcinogen
162 9,1 0-Anthracenedione, 000082439
1,8-dichloro-
163 9,1 0-Anthracenedione, 000084457
2,3-dichloro-
164 9,1 0-Anthracenedione, 000072480
1,2-dihydroxy-
165 9,1 0-Anthracenedione, 000117124
1,5-dihydroxy-
166 9,1 0-Anthracenedione, 000117102
1,8-dihydroxy-
(LC666BV
IVJ DQ NQ)
LDLo:500mg/kg,
ipr-rat
167 9,10-Anthracenedione, 000084605
2,6-dihydroxy-
168 9,10-Anthracenedione, 000128916
1,5-d ihydroxy-4,8-
dinitro-
169 9,10-Anthracenedione, 006448904
1,5-dimethoxy-
170 9,10-Anthracenedione, —
1,5-d imethoxy -4,8-
dinitro-
171 9,10-Anthracenedione, 000082359
1,5-dinitro-
172 9,10-Anthracenedione, 000129395
1,8-dinitro-
173 9,10-Anthracenedione, 000082213
1,5-diphenoxy-
174 9,10-Anthracenedione, —
1 -hydrazino-2-methy I-
175 9,10-Anthracenedione, 000129431
1-hydroxy-
176 9,10-Anthracenedione, 000081652
1 -hydroxy-4-nitro-
330
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
34d,55 —
34a, 52
23,58
33,15,58,55
34d, 55 — — — — 2)116
34g, 58
34d,55
34d,55
34d,55
28,54
34c, 54
34d,55
34b, 53
34f, 57
34f, 57
331
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgQ, mg/kg Toxicology TLV Carcinogen
177 9,10-Anthracenedione, 000082393 — — — —
1-methoxy-
178 9,10-Anthracenedione, 000084548 — — — —
2,methyl-
179 9,10-Anthracenedione, 000082382 — — —
1-methlamino-
180 9,10-Anthracenedione, 000128858 —
1-(methlamino)-4-
[(4-methylphenyl)amino] -
181 9,10-Anthracenedione, 000129157
2-methyl-1-nitro-
182 9,10-Anthracenedione, 000082348 — — — —
1-nitro-
183 9,10-Anthracenedione, 000081583 — — — —
1,4,5,8-tetrachloro-
184 9,10-Anthracenedione, — — — — —
1-(4-tolysulfonamido)-
2-chloro-
185 9,10-Anthracenedione, 000081549 — —
1,2,4-trihydroxy-
186 1,5-Anthracenedisul- 000117146 — — — —
fonic acid, 9,10-dihydro-
9,10-dioxo-
187 1,8-Anthracenedisul- 000082484 — — — —
fonic acid, 9,10-dihydro-
9,10-dioxo-
188 2,6-Anthracenedisul- 000128869 — — — —
fonic acid, 4,8-diamino-
9,10-dihydro-1,5-
dihydroxy-9,10-dioxo-
189 2,6-Anthracenedisul- 006492859 — — —
fonic acid, 9,10-dihydro-
1,5-dihydroxy-9,10-dioxo-
332
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
— 34e, 56 — — —
34b,53
28,56
28,56
34b, 53
34c, 54
12,39, 54
34a,52
34g, 58
Sulfonation 15,55
15.55
— 33,55
58
33,55
15,58
(Continued)
333
-------
TABLE B-2. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDgg, mg/kg Toxicology
TLV Carcinogen
190 2,6-Anthracenedisul-
fonic acid, 9,10-dihydro-
1,5-dihydroxy-4,8-
dinitro-9,10-dioxo-
191 2,6-Anthracenedisul-
fonic acid, 9,10-dihydro-
9,10-dioxo-
000084504
192 1-Anthracenesulfonic
acid, 9,10-dihydro-
9,10-dioxo-
000082495
193 1-Anthracenesulfonic
acid, 9,10-dihydro-5-
nitro-9,10-dioxo-
000082508
194 1-Anthracenesulfonic
acid, 9,10-dihydro-8-
nitro-9,10KJioxc~
000129373
195 2-Anthracenesulfonic
acid
015100535
196 2-Anthracenesulfonic
acid, 1-amino-4-(3-
amino-4-sulfo-anilino)-
9,10-dihydro-9,10-dioxo-
000128994
197 2-Anthracenesulfonic 000081696
acid, 1-amino-4-(4-
amino-3-sulfo-anilino)-
9,10-d ihydro-9,10<1 ioxo-
198 2-Anthracenesulfonic 000116814
acid, 1-amino-4-bromo-
9,10-dihydro-9,10-dioxo-
199 2-Anthracenesulfonic
acid, 1-amino-9,10-
dihydro-9,10-dioxo-
000083625 —
200 2-Anthracenesulfonic
acid, 3-amino-9,10-
dihydro-9,10-dioxo-
033016692
334
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses References
33,55
58
15,58
34c, 54
0.518/1974
34d,55
34d,55
34g,58
34h, 59
34h, 59
12,59
15,59
15,58
(Continued)
335
-------
TABLE B-2. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD», mg/kg Toxicology
TLV Carcinogen
201 2-Anthracenesulfonic —
acid, 1-amino-9,10-
dihydro-4-(3-nitro-4-sul-
foanilino)-9,10-dioxo-
202 2-Anthracenesulfonic —
acid, 1-amino-9,10-
d i hy d ro-4- (4-n itro-3-
sulfoanilino)-9,10-dioxo-
203 2-Anthracenesulfonic 00084480
acid, 9,10-dihydro-
9,10-dioxo-
204 2-Anthracenol
000613149
205 Anthranilic acid, N-(4-
amino-1-anthraquinonyl)-
206 Anthranilic acid, N-[(3-
carboxy-4-chlorobenzene)-
sulfonyl]
207 Anthranilic acid,
N-carboxy methyl-
000612420
208 Anthranilic acid,
4-chloro-
000089770
209 Anthranilic acid,
N-methyl
000119686
210 Anthranilic acid,
N-(4-nitro-1-
anthraquinonyll-
211 Anthranilic acid,
4-sulfo-
000098431
212 Anthranilic acid,
5-sulfo-
025352276
213 Anthraquinone, 1-
acetam ido-4-bromo-
N-methyl-
336
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10® kg/year Uses References
34h, 59 —
34h,59 — — —
34c,54
34g, 58 — — —
Reduction 34e, 56 — — — — —
10,30
5,19
— 29b,49
5,19
28 56
38,61
5,19
34g gg
(Continued)
337
-------
TABLE B-2. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LDg0, mg/kg Toxicology
TLV Carcinogen
214 Anthraquinone, 1-
acetamido-N-methyl-4-
p-toluidino-
215 Anthraquinone, 1-amino-
4-anilino-2-bromo-
216 Anthraquinone, 2-amino-
1 -bromo-3-ch loro-
217 Anthraquinone, 2-
amino-1,3-dibromo-
218 Anthraquinone, 1,5- — —
bis(dinitrophenoxy)-
4,8-dinitro-
219 Anthraquinone, 1-
hydrazino-2-methyl
(See 9,10-Anthracenedione, 1-hydrazine-2-methyl-)
220 Anthraquinone, 1,4,
5,8-tetrahydroxy-
000081607
221 2-Anthronic acid, 9,10-
dihydro-1-nitro-9,10-
dioxo-
000128676
(LC666BV
LDLo:2000
mg/kg, rat
IVJ DNW EVQ)
222 9-Anthrol
000529862
223 20Anthro-o-toluidide, 001830779
3-hydroxy-
224 2-Anthroylchloride,
9,10-dihydro-1-nitro-
9,10-dioxo-
225 Azobenzene
000103333 1000 rat
(RNUNR)
LDLo:50 mg/kg,
unk-mam
TDLo:17gm/kg/
2YITFX:NEO
scu-rat
226 Azoxybenzene
000495487 620 rat
(ONR&UNR)
Limited animal
experiments show
moderate toxicity
TDLo:4mg/kg
TFXiCDR scu-rat
338
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
34e, 56 — — — — —
28,59
34a,62
12,58
34d,55
34g,58
34b,53 — — — — 2)117
26,54
29a, 48
34g, 58
34b, 53
34b, 53
25a,43 — — — — 2)138
3)427
25a,43 — — — — 2)140
3)428
(Continued)
339
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
227 Benzaldehyde, 4 [N-
jvbuty I-N- (2-ch loro-
ethyDamino] -
228
Benzaldehyde, c>-
chloro-
000089985
(VHR BG)
LDLo: 10 mg/kg,
ipr-mus
229 Benzaldehyde, £-
[(2-chloroethyO-
methylamino] -
000094315
230 Benzaldehyde, 4-
[(2-chloroethyl)
ethylamino]
002643074
231 Benzaldehyde, p-
(diethylamino)
000120218
232 Benzaldehyde, £-
dimethylamino
000100107
(VHR DN1&1)
LD50:620 mg/kg,
ipr-rat
233 Benzaldehyde, m-
nitro-
000091616
234 Benzaldehyde, £-
nitro-
000555168
(WNR DVH)
LD50:545 mg/kg,
ipr-rat
235 Benzamide, N-(4-amino- 000081469
1-anthraquinonyl)
236 Benzamide, N-(4-amino- 000081469
9,10-dihydro-9,10-dioxo-
1-anthracenyO-
237 Benzamide, N-(5-amino- 000117066
9,10-dihydro-9,10-dioxo-
1-anthracenyD-
238 Benzamide, 4-amino- —
N-ethyl-N-1-naphthyl-
239 Benzamide, p-amino-N- —
[7-(4-hydroxy-2-
naphthalenesulfonic acid)
340
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
9, 17
6,62
2)154
9, 18
2b, 17
6,8,17
2c, 18
0.007/1974
2)154
5, 19
30,50
2)155
Reduction 37,59
37,59
56
0.019/1974
34c, 54
Reduction
23a, 34
Reduction
5, 19
23i, 42
341
(Continued)
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) '-'•'BO' m9^g Toxicology TLV Carcinogen
240 Benzamide, 3-amino-4- 017481275 — — — —
methoxy-
241 Benzamide, N-(4-amino- — — — — —
5-methoxy-2-methylphenyO-
242 Benzamide, N-1- — — — — —
anthraquinonyl-
243 Benzamide, N-(5-anthra- — — — — —
quinonyl-1-nitro)-
244 Benzamide, 3-chloro- 010286756 — — — —
N- (p-chlorophenyl)
245 Benzamide, N-(4- 000081458 — —
chloro-1-anthraquinonyl)
246 Benzamide, N-(9,10- — — — — —
d ihydro-9,10-d ioxo-4-
n itro-1 -anth raceny I) -
247 Benzamide, N-ethyl-N- — — — — —
1-naphthyl-p-nitro-
248 Benzamide, N-[4-(5- 000117464 — — — —
hydro xy-2,7-naphthalene-
disulfonic acid)]
249 Benzamide, N-(4-methoxy- — — — —
2-methyl-5-nitrophenyl)
250 Benzamide, 4-methoxy- — — — — —
3-nitro-
251 Benzamide, N-[4-(2- — — — — —
nitrobenzenesulfonic acid)
252 Benzamide, p-nitro-N- — — — — —
[7-(4-hydroxy-2-
naphthalene sulfonic
acid)]
253 Benzanilide, 4'-amino- 017625831 — — — —
254 Benzanilide, 4'-amino- 000120003 — — — —
2',5'-diethoxy-
342
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
21,34
29b, 49
12,31,59
34c, 54
12,30
Chlorination 12,56
59
34e, 56
34h,59
23a, 34
23c, 36
29b, 49
21,34
25c, 45
23i, 42
9c, 29 — — —
19,33
(Continued)
343
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgg. mg/kg
Toxicology
TLV
Carcinogen
255 Benzanilide, 4'-amino- 062680509
2',5'-dimethoxy-
256 Benzanilide, 3'-amino-
4'-sulfo-
257 Benzanilide, 3,3'-
diamino-
000101122
258 Benzanilide, 2',5'-
diethoxy-
259 Benzanilide, 2',5'-
diethoxy-4'-nitro-
260 Benzanilide, 2',5'-
dimethoxy-
261 Benzanilide, 2',5'-
d imethoxy-4'-nitro
262 Benzanilide, 3,3'-
dinitro
000101246
263 Benzanilide, 4'-nitro- 003393962
264 7H-Benz[del anthracen- 000082053
7-one (Benzanthrone)
1AQ IVJ)
265 7H-Benz[de] anthracen- 013456809
7-one, 3-amino-
266 7H-Benz[de] anthracen- 050607200
7-one, 3-amino-2-nitro-
267 7H-Benz[de] anthracen- —
7-one, 3-benzoyl-
268 7 H-Benz [del anthracen- 000081969
7-one, 3-bromo-
269 7H-Benz[de]anthracen- 006409445
7one, 3-chloro-
270 7H-Benz[de] anthracen- 000081981
7-one, 3,9-dibromo-
LDLo: 1000 mg/kg,
ipr-mus
344
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
19,33
Reduction 25c, 45
25c, 45
20,33
20,33
20,33
20,33
25c, 45
9c, 29
26,54
0.380/1974
2)161
3)440
34c,54
34c, 54
26,54
12,34,54 —
0.380/1974
12,54
12,54
(Continued)
345
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5(), mg/kg
Toxicology
TLV
Carcinogen
271 7H-Benz[de]anthracen- — —
7-one, 3,9-dichloro-
272 7H-Benz[de]anthracen- — —
7-one, 2-hydroxy-
273 7H-Benz[de]anthracen- 006535677
7-one, 2-methoxy
274 Benzenamine derivatives, (See Aniline derivatives)
275 Benzene, 1-chloro-2,4- 000119211
dimethoxy-5-nitro-
276 Benzene, 1-chloro-2,5- 006940530
d imethoxy-4-nitro-
277 Benzene, 1-chloro-2,4- 000097007 1070 rat
dinitro-
(WNR BG
ENW)
278 Benzene, 1-chloro-2-
nitro-
000088733 288 rat
279 Benzene, 1-chloro-3-
nitro-
000121733
TCLo:12 ug/m3
TFX:EYE, ihl-hmn
280 Benzene, 1-chloro-4- 000100005 1414 mus
nitro-
(WNR DG)
USDS air: TWA
1 mg/m3 (skn)
281 Benzene, m-dich lore- 000541731
282 Benzene, 1,2-dichloro- —
4-nitro-
283 Benzene, 1,2-dichloro- 000099547
4-nitro-
284 Benzene, 1,4-dichloro- 000089612
2-nitro-
285 Benzene, 2,4-dichloro- 000611063
1-nitro-
286 Benzene, p-diethoxy- 000122952 —
3A6
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10® kg/year Uses References
12,54 —
34c, 54
34c,54
40,63 —
19,33 — — — —
3,30 — — — — 2)165
7a, 30 — — — — 2)165
25a,43
7a, 20 — — — — 2)165
25b,44 — — — —
40,63
12,29 —
18,32 — — —
25b, 44
1Q OO
l«7( OO ~~~" —
(Continued)
347
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD, mg/kg
Toxicology
TLV
Carcinogen
287 Benzene, 1,4-diethoxy-
2-nitro-
288 Benzene, ja-dimethoxy- 000150787
(10RD01)
LDLo:300 mg/kg,
ipr'mus
LD50:1100mg/kg,
ipr-rat
289 Benzene, 1,4-dimethoxy- 000089394
1-nitro-
290 Benzene, 2,4-dimethyl- 000089872 —
1-nitro-
291 Benzene, m-dinitro 000099650 42 bdw
(WNR CNW)
LDLo:
cat
USDS air: TWA
1 mg/m3 (skn)
292 p-Benzenedisulfonic 000098442
acid, 2-amino-
293 1,3-Benzenedisulfonic 000120989
acid, 5-amino-4-hydroxy-
294 1,3-Benzenedisulfonic 000137508
acid, 4,5-diamino-
295 m-Benzenedisulfonic 000088391
acid, 4-formyl-
296 m-Benzenedisulfonic 000096775
acid, 4-hydroxy-
297 1,3-Benzenedisulfonic
acid, 4-hydroxy-5-nitro-
298 p-Benzenedisulfonic 000119006
acid, 2-nitro-
299 Benzenesulf inic acid, 000100038
p-chloro-
300 Benzenesulfinic acid, —
2-chloro-5-nitro-
301 Benzenesulfonamide, 3- —
amino-N-n-butyl-4-
methoxy-
348
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
20,33
19,33
2)166
19,33
42,63
25c, 45
2)166
8a, 25
32,51
15,45
11,61
32,51
32,51
8a,25
7a,20
9a, 27
Reduction 8a, 25
(Continued)
349
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) *-D50> mg/kg Toxicology TLV Carcinogen
302 Benzenesulfonamide, 052298449 — — — —
4'-amino-2',5'-
d imethoxy-N-pheny I-
303 Benzenesulfonamide, 000080239 — — — —
3-amino-4-hydroxy-
N-methyl-
304 Benzenesulfonamide, — — — — —
N-jvbutyl-4-methoxy-
3-nitro-
305 Benzenesulonamide, 000098646 LDLo:500 mg/kg, — — —
p-chloro- (ZSWR DG) rat
306 Benzensulfonamide, 000137473 — — — —
4-chloro-N-N-dimethyl-
3-nitro
307 Benzenesulfonamide, 000137484 — — — —
4-chloro-N-methyl-3-
nitro-
308 Benzenesulonamide, 000097096 — — — —
4-chloro-3-nitro-
309 Benzenesulfonamide, — — — — —
N-(2,5-dimethoxy-4-
nitro phenyl)-
310 Benzenesulfonamide, 034238374 — — — —
N-(2,5-dimethoxyphenyD-
311 Benzenesulfonamide, 4- — — — — —
hydroxy-N-methyl-3-nitro-
312 Benzenesulfonanilide, — — — — —
2-amino-N-ethyl-5-
nitro-
313 Benzenesulfonanilide, 000137495 — — — —
4-chloro-3-nitro-
314 Benzenesulfonate, 8- — — — — —
amino-3-, 6-disulfo-1-
naphthyl-
350
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10® kg/year Uses References
20,33 — — —
26,46
8a, 25
7a,20 — — — — 2)169
7b, 21
7b,21
7b,21 — — 0.367/1974
20,33
20,33
26,46
9b, 28
7b, 21
23c, 36
(Continued)
351
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgQ, mg/kg Toxicology TLV Carcinogen
315 Benzenesulfonic acid, — — — — —
3-acetylamino-
316 Benzenesulfonic acid, 000096786 — — — —
5-(acetylamino)-2-amino
317 Benzenesulfonic acid, — — — — —
5-acetam ido-2-am i no-4-
methoxy-
318 Benzenesulfonic acid, 000121471 —
m-amino-(metanilic acid)
319 Benzensulfonic acid, 000088211
2-amino(orthanilic acid)
320 Benzenesulfonic acid, 000119700 — — — —
5-amino-2[4-(aminophenyl)
aminol-
321 Benzenesulfonic acid, 000091305 — — — —
5-amino-2-anilino
322 Benzenesulfonic acid, 014846083 — — — —
2-(|>-amino-anilino)-5-
nitro-
323 Benzenesulfonic acid, 029452720 — — — —
2-amino-4-(benzoylamino)-
324 Benzenesulfonic acid, 2- 004988323 — — —
[ (4-am ino-3-bromo-9,10-
dihydro-9,10-dioxo-1-anthra-
cenyl)amino-5-methyl-
325 Benzenesulfonic acid, 000133744 — —
2-am i no-5-ch loro-
326 Benzenesulfonic acid, 000098362 — — — —
3-amino-4-chloro-
327 Benzenesulfonic acid, — — — — —
4-am i no-2-ch loro-5-
hydroxy-
328 Benzenesulfonic acid, 002706287 — — — —
2-amino-4',5-(diazo)
di-, disodium salt
352
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
25a, 43
9b, 28
8b, 26
5, 19 — — 0.591/1974
25a, 43
7b, 21
5, 19
9b, 28
20,28
20,28
25c, 45
34h,59
9a, 27
Reduction 8a, 25
15,32
4, 16
(Continued)
353
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) '-'-'50' m9^g Toxicology TLV Carcinogen
329 Benzenesulfonic acid, — — — — —
2-amino-4,5-dichloro-
330 Benzenesulfonic acid, 000098373 — — — —
3-amino-4-hydroxy-
331 Benzenesulfonic acid, — — — — —
3-amino-2-hydroxy-5-
nitro-
332 Benzenesulfonic acid, 013244332 — — — —
2-amino-5-methoxy-
333 Benzenesulfonic acid, 000098420 — — — —
2-amino-5-methoxy-
334 Benzenesulfonic acid, — — — — —
5-amino-4-methoxy-2-
nitro-
335 Benzenesulfonic acid, 000096753 — — — —
2-amino-5-nitro-
336 Benzenesulfonic acid, 000712243 — — — —
4-a m i no-2-n itro-
337 Benzenesulfonic acid, 000104234 — — — —
jD-[(p-aminophenyl)azo] -
338 Benzenesulfonic acid, — — — — —
5-amino-2-(p/toluidino)-
339 Benzensulfonic acid, 3-
(amino-4-tosyl)-4-methoxy-
(See Benzenesulfonic acid, 4-methoxy-3-(p>-toluenesulfonamido)-
340 Benzenesulfonic acid, 000088357 — — — —
2-anilino-5-nitro-
341 Benzenesulfonic acid, — — — — —
2-o-an isid ino-5-n itro-
342 Benzenesulfonic acid, — — — — —
4-chloro-3,5-diamino-
354
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
Reduction 17,31
8a, 25
Partial Reduction 9b, 28
15,27
7c,22
7c, 22
8b, 26
9b, 28
25c, 45
4, 16
0.197/1974
13
Reduction 9b, 28
3,28
3,28
Reduction 8a, 25
(Continued)
355
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q' m9/k9 Toxicology TLV Carcinogen
343 Benzenesulfonic acid, 004515268 1640 rat
2-chloro-3,5-dinitro-
344 Benzenesulfonic acid, — — — — —
3-chloro-4,6-dinitro-
345 Benzenesulfonic acid, 038185067 — — — —
4-chloro-3,5-d in itro-
346 Benzenesulfonic acid, — — — — —
4-chloro-3-hydrazino-
347 Benzenesulfonic acid, — — — — —
5-chloro-2-hydraxino-
348 Benzenesulfonic acid, 006973133 — — — —
5-chloro-4-methyl-2-
nitro-
349 Benzenesulfonic acid, — — — — —
p-chloro-3-(3-methyl-5-
oxo-2-pyrazolin-1-yl)-
350 Benzenesulfonic acid, — — — — —
m-chloro-6-(3-methyl-5-
oxo-2-pyrazolin-1-y D-
351 Benzenesulfonic acid, 000121186 — — — —
4-chloro-3-nitro-
352 Benzenesulfonic acid, 000096731 — — — —
2-chloro-5-nitro-
353 Benzenesulfonic acid, 000088631 — — — —
2,4-diamino-
354 Benzenesulfonic acid, 000088459 — — — —
2,5-diamino-
355 Benzenesulfonic acid, — — — — —
2,5-diamino-4-methoxy-
356 Benzenesulfonic acid, 000939957 — — — —
3.4-dichloro-
357 Benzenesulfonic acid, — — — — —
2,5-dichloro-4-hydrazino-
356
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
9b, 28
2)170
12,24
4,25
4,25
Reduction 4,27
39,62
4,25
4,29
15,23
25
9b, 28
7e, 24
9b, 28
Reduction 8b, 26
15,31
Reduction 4,32
(Continued)
357
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) ^' m9^9 Toxicology TLV Carcinogen
358 Benzenesulfonic acid, 000084571
2,5-dichloro-4-(3-methyl-
5-oxo-2-pyrazolin-1-yl)-
359 Benzenesulfonic acid, —
4,5-d ich loro-2-n itro-
360 Benzenesulfonic acid, 000089021
2,4-dinitro-
361 Benzenesulfonic acid, —
3,5-dinitro-2-hydroxy-
362 Benzenesulfonic acid,
4-(N-ethylanilinonethane)
(See M-Toluenwulfonic acid, -(N-ethylanilino)
363 Benzenesulfonic acid, 000091258
o-formyl-
364 Benzenesulfonic acid, 000098715
p-hydrazino-
365 Benzenesulfonic acid, —
4-hydroxy-3,5-dinitro-
366 Benzenesulfonic acid, 000616853
4-hydroxy-3-nitro-
367 Benzenesulfonic acid, 022117813
4-methoxy-3-nitro-
368 Benzenesulfonic acid,
4-methoxy-3-(£-
toluenesulfonamido)-
369 Benzenesulfonic acid, 000097063
4-methyl-3-nitro-
370 Benzenesulfonic acid, 000089361
£-(3-methyl-5-oxo-2-
pyrazolin-1-yl)-
371 Benzenesulfonic acid, 000098475
m-nitro-
358
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
4,32
17,31
7e, 24
9b, 28
39,62
2a, 16
8a, 25
8a, 25
32,51
15,25
22
8b, 26
38,61
4,16
25a, 43
5, 19
(Continued)
359
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) '-^50,' r"9/'c9 Toxicology TLV Carcinogen
372 Benzenesulfonic acid, 000080820 — — — —
o-nitro-
373 Benzenesulfonic acid, — — — — —
5-nitro-2-<£-
nitroanilino)-
374 Benzenesulfonic acid, — — — — —
5-nitro-2-(p-toluidine)-
375 Benzenesulfonic acid, — — — — —
5,5'-ureylenebis-
(2-amino-
376 Benzenesulfonic acid, — — — — —
5,5'-ureylenebis[2-
am ino-4-methoxy-
377 Benzenesulfonic acid, — — — — —
5,5'-ureylenebis[4-
methoxy-2-nitro-
378 Benzenesulfonic acid, — — — — —
5,5'-ureylenebis[2-nitro-
379 Benzenesulfonyl chloride, 020628335 — — — —
2-amino-5-nitro-
380 Benzenesulfonyl chlo- 000098602 4250 rat
ride.p-chloro- (WSGR DG)
381 Benzenesulfonyl chlo- — — — —
ride, 4-chloro-2-methyl-
382 Benzenesulfonyl chlo- 004533953 — — — —
ride, 2-chloro-5-nitro-
383 Benzenesulfonyl chlo- 004533964 — — — —
ride, 4-chloro-2-nitro-
384 Benzenesulfonyl chto- 000097085 — — — —
ride, 4-chloro-3-nitro-
385 Benzenesulfonyl chlo- — — — — —
ride, 4-hydroxy-3-nitro-
360
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
7b, 21
9b, 28
9b, 28
Reduction 25a, 43
Ditto
7c, 22
8,22
25a, 43
9b, 28
7a,20
2)171
28.47
9a,27
7a, 20
7b, 21
26,46
(Continued)
361
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDg0,mg/kg
Toxicology
TLV
Carcinogen
386 Benzenesulfonyl chlo- 022117799
ride, 4-methoxy-3-nitro-
387 1,2,4-Benzenef ricar- —
boxylic acid, 5-amino
388 1,2,4-Benzenetricarbox-
ylic acid, 5-amino
389 1,2,4-Benzenetricar-
boxylic acid, 5-nitro-
390 Benzene, 1,2,4-tri-
chloro-5-nitro-
000089690 100bdw
(WNR BG
DG EG)
391 11H-Benzo [a] carbazole- 000086191
30carbox-p-anisidide,
2-hydroxy-
392 11H-Benzo [a] carbazole- 000084435
3-carboxylic acid,
2-hydroxy-
393 Benzoic acid, 5-amino- 005855787
2-chloro-4-sulfo-
394 Benzoic, 2-(3-amino- 041378341
4-hydroxybenzoyD-
395 Benzoic acid, p_-amino- —
[7-(4-hydroxy-2-
naphthalenesulfonic
acid)]
396 Benzoic acid, 4-(amino- 053250843
sulfonyl)-2-chloro-
397 Benzoic acid, p_-
benzoyl-
000085529
LDLo:32mg/kg
mus
398 Benzoic acid, 2-(4- —
carboxy-3-ch loro-benzoy I) -
399 Benzoic acid, £-(car- 000135137
boxymethyl)-thio-
362
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Reduction 41,63
11,63
41,63
40,63
2)172
23f, 39
23f, 39
Reduction 39,62
Ditto
34a, 52
23h,41
39,62
34a, 52
2)183
Oxidation
34b, 53
43,19
(Continued)
363
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
400 Benzole acid,£-<£-
chlorobenzoyl)-
000085563
401 Benzoic acid, 2- 000137644
ch loro-5-ch lorosu If ony I-
402
Benzoic acid, 4-
chloro-3,5-dinitro-
000118978
403
Benzoic acid, 2-
chloro-5-nitro-
002516963
404 Benzoic acid, o-(4- 00085541
chloro-3-nitrobenzoyl)-
405 Benzoic acid, 2-chloro-
5-nitro-4-sulfo-
406 Benzoic acid, o- 015254270
(3-chloro-£-toluoyl)-
407 Benzoic acid, 2,5-
dichloro-
000050793
(QVR BG EG)
LD50:1200 mg/kg,
scu-mus
408 Benzoic acid, 2-(2,3-
dichlorobenzoyl)-
409 Benzoic acid, 2,2'-
dithiodi-
000119802
410 Benzoic acid, 2-[3-ethyl-
1-(4-methyl-3-nitro-
phenyDtriazenyl] -5-sulfo-
411 Benzoic acid, 2-(4- 043046975
hydroxy-3-nitrobenzoyl)-
412 Benzoic acid, £-
mercapto-
000147933
413 Benzoic acid, 4-
methoxy-3-nitro-
000089418
414 Benzoic acid, m-nitro- 000121926
LD50:670 mg/kg,
ipr-rat
364
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
34a, 52
10,30
3,30
10,30
34a, 52
Oxidation 39,62
12,53
8,32
2)184
34a, 52
43,19
7e, 24
34a, 52
43, 19
21,34
Oxidation
4,19
2)187
(Continued)
365
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgg, mg/kg
Toxicology
TLV
Carcinogen
415 Benzoic acid, 2-(6L
keto-2-oxobenzoxazoyl)-
416 Benzoic acid,£-(p- 00008552
toluoyl)-
417 Benzophenone, 4,4'- 000090937
bis(diethylamino)-
418 Benzophenone, 4,4'- 000090948
bis(dimethylamino)-
419 Benzothiazole, 2-(p- 000092364
aminophenyl)-6-methyl-
420 7-Benzothiazole sul- 000130176
fonic acid, 2-(4-amino-
phynyl)-6-methyl-
421 Benzo[b]thiophen-3 000130030
(2H)-one
422 1 H-Benzotriazole,
1,2,3-
000095147
(T56
BMNNJ)
— Ltd animal exp.
indicate mod. toxi-
city, LD50:1000
mg/kg, ipr-mus
423 Benzoxazole, 2-
methyl-
000095216 717 rat
(T56 BN
DOJC)
424 Benzoxazole, 2-
methyl-5-nitro-
032046518
425 2(3H)Benzoaxazolone 000059494
426 2(3H)Benzoxalone, 004694911
6-nitro-
427 Benzoyl chloride,
m-nitro-
000121904 2460 rat
(WNR CVG)
428 Benzylamine, N-ethyl- 000092591
N-phenyl-
366
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
34a, 52
34a, 52
6,17
6,7 18
0.051/1974
17,50
17,50
43,19
4,23
2)199
3)444
26,46
2)200
26,46
26,46
26,46
4,19
2)201
6,7,17
0.217,
0.482/1974
(Continued)
367
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
429 4',4'"-Biacetanilide
004471107 —
(1VMRDR
DMV1)
TDLo: 5300 mg/kg/
35WCTFX:CAR
orl-rat
430 4',4'"-Biacetanilide
3',3"'-diamino-
431 4',4'"-Biacetanilide,
3',3'"-dinitro-
006378901 —
432 [1,1'-Bianthracene]-
9,9',10,10'-tetrone,
2,2'-dimethyl-
019634903
433 2,2'"-Bi-2-naphtho-o-
anisidide, 3',3"'-
dihydroxy-
434 Biphenyl, 4,4'-diamino- 000091941
3.3'-dichloro-, (ZR BQ DR
hydrochloride n
LDLo:4740 mg/kg,
orl-rat
USDS: CAR
TDLo:26gm/kg/
SOW
TFXrCAR orl-rat
TDLo:6.5 mg/kg/
44WI
TFX:CAR scu-rat
435 [1,1'-Biphenyl]-4,4'- 004746752
diamine, 2,2'-dimethoxy-
436 [1,1'-Biphenyl]-4,4'- 021136709
diamine, sulfate
Experimental
carcinogen
437 3,3'-Biphenyldiol, 2,
2'-dinitro-
438 2,2'-Biphenyldisulfonic 000117613
acid, 4,4'-diamino-
439 3,3'-Biphenyldisulfonic 003365900
acid, 4,4'-diamino-
440 3-Biphenylsulfonic 002051890 —
acid, 4,4'-diamino-
441 3,3',4,4'-
B ipheny Itetramine
000091952 LDLo:3000 mg/kg,
rat
TDLo:9000 mg/kg/
30D1
TFX:NEO orl-rat
368
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10*> kg/year
Uses
References
25a, 43
2)215
Reduction 25a, 43
25a, 43
25,53
7c, 22
7b, 21
2)173
Alkaline Reduction 7c, 22
25a, 43
3)406,
5th ed., 1979
Reduction 26,46
Ditto
5. 19
25a, 43
15,43
15,43
25a, 43
2)221
(Continued)
369
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
442 [m-m'-Bitolyl]-4,4-
diamine
443 [m-nV-Bitolyl]6,6'- 028425550
disulfonic acid, 4,
4'-diamino-
444 Butanamide, N,N'-(3,3'- 000091963
dimethyl[1,1'-biphenyl]-
4,4'-diyl)bisl3-oxo-
445 Carbazole, 3-amino-9- —
eth*'- (T B656
HNJ DZ H2)
144 rat
446 Carbazole, 9-ethyl-
447 Carbazole, 9-ethyl-
3-nitro-
448 N,N'-Carbonyl-bis(4- —
methoxy-methanilic acid)
449 Carboxtyril, 4-hydroxy-
1-methyl-
LDLo:4650
mg/kg, rat
450 £-Cresidine
(See Aniline, 2-methoxy-5-methyl-)
451 p-Cresol, 2-nitro
000119335 3360 rat
452 2,3-Cresotic acid —
453 Cyclopenta-[cd]- —
phenalene, 1H-,5,7-
diketo
454 Dianiline, 4,4'- —
isopropylidene
455 Dianiiine, 2,4'-thio- —
456 Dianiline, 4,4'-thio- 000139651
457 Di~£-anisidine, 4,4'- —
cyclohexylidene-
370
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Alkaline Reduction 29a, 48
Reduction 38,61
29a, 48
20, 20
6, 20
6, 20
8b, 26
3, 19
2)296
15,31
9,30
1.15
2)352
2c, 18
22, 18
2c, 17
7c,22
(Continued)
371
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
458 <3-Dianisidine dihydrochloride
(See [1,1'-Biphenyl]-4,4'-diamine,2,2'-dimethoxy)
459 Diazoaminobenzene 000136356 224 rat
(RNUNMR)
TDLo:37gm/kg/
61W
TFX:CAR skn-mus
460 Diformo-rn-
pheny lened iam ine
461 Diformo-m-pheny-
lened iam ine,4-n itro-
462
Disulfide, bis(o-
nitrophenyl)
021387939
463 Ethanolamine, N-phenyl
(See Ethanol, 2-anilino)
464 Ethanol, 2-m-(amino-
anilino)-
465 Ethanol, 2-([j-amino-
phenoxy), hydrochloride
466 Ethanol, 2-anilino-
000122985 2230 rat
(Q2MR)
467
Ethanol, 2-(N-£-
butylanilino)-
468 Ethanol, 2-
(N-ethylanilino)-
000092002
469
Ethanol, 2-
(N-ethylanilino)-
000092502
470 Ethanol, 2-(N-ethyl-
£-toluidino)-
013386602
471 Ethanol, 2-(N-
methylanilino)-
000093903 2830 rat
(Q2N1&R)
472 Ethanol, 2-(m-
nitroanilinol-
372
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year
Uses
References
19,4, 15
2)1149
3)609
25c, 45
25c, 45
22,21
Reduction 25c, 45
Ditto
28,47
2b, 17
2b, 17
25b, 44
6-10,17
0.163/1974
30,50
2c, 18
25c, 45
(Continued)
373
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity/
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
473 Ethanol, 2-(p-
nitrophenoxy)-
016365278
474 Formamide, N-(3-
nitrophenyl)
000102385
475 Formanilide, 3'-amino-
476 oFormotoluidide,
4-nitro-
026198118
477 Hydrazine, 1-
anthraquinonyl-
478 Hydrazine, (p-
chlorophenyl)-
001073694
479 Hydrazine, 1-(5-
chloro-o-tolyl)-
480 Hydrazine, 1,2-
diphenyl
000122667 301 rat
(RMMR)
TDLo:16gm/kg/
1YI
TFX:NEOscu-rat
481 2-Hydrazinesulfonic
acid, 1-(1-
anthraquinonyl)-
482 Hydroxylamine,
N-phenyl-
000100652
(QMR)
TDLo:500 mg/kg
TFX:SKN skn-hmn
LDLo: 50 mg/kg,
scu-rbt
483 Isophthalic acid,
5-amino-
000099310
484 Isophthalic acid,
5-nitro-
000618882
485 4,4'-lsopropylidenedianiline
(See Dianiline, 4,4'-isopropylidene-)
486 Metanilicacid
(See Benzenesulfonic acid, m-amino)
487 Metanilicacid, 4-chloro
(See Benzenesulfonic acid, 3-amino-4-chloro-l
374
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10*5 kg/year
Uses
References
28,47
25c, 45
Reduction 25c, 45
29b,49
35,59
Reduction
4,27
4,48
Reduction 25a, 43
2)619
35,59
Neutral
Reduction
25a, 43
2)628
Reduction 22,34
22,34
(Continued)
375
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
488 Metanilic acid, 6-
chloro
000088437
489 Metanilic acid, 2-hydroxy-
(See Benzenesulfonic acid, 3-amino-4-hydroxy-!
490 Metanilic acid, 4-
hydroxy-
000098373
491 Metanilic acid, 4-
hydroxy-5-nitro-
000096935
492 Metanilic acid, N,N-
diethyl-
493 Metanilic acid, 6-nitro-
494 Methanesulfonic acid,
anilino-
495 Methanesulfonic acid,
o-anisidino
496 Methanol, 4,4'-bis
(diethylaminophenyl)-
497 Naphthalene, 2-ethoxy 000093185
(L66J CO2)
LDLo:100 mg/kg,
ipr-mus
498 Naphthalene, 1-nitro- 000086577 —
(L66J BNW)
499 2-Naphthalenecarbox- 005442400 120 rat
amide, N-(3-chlorophenyD-
3-hydroxy-
500 2-Naphthalenecarbox- 053232205 —
amide, N-(ethoxyphenyl)-
3-hydroxy-
501 1,5-Naphthalenediol 000083567 —
502 1,3-Naphthalene-disul- 000118332 —
fonic acid, 6-amino-
376
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Reduction 9b, 28
Reduction 32,51
Partial
Reduction
83,25
25a, 43
25a, 43
2c, 18
0.211/1974
7c, 22
0.370/1974
6,7, 17
23g, 40
2)775
23a, 34
2)776
25b, 44
9c, 29
23d, 37
23g,40
23h, 41
(Continued)
377
-------
TABLE B-2. (Continued)
Item
No.
503
504
505
506
507
508
509
510
511
512
513
514
Compound
Name and
Formula
1,3-Naphthalene-
disulfonic acid, 7-
amino-
1,3-Naphthalene-
disulfonic acid, 7-
hydroxy-
1,5-Naphthalene-
disulfonic acid
1,5-Naphthalene-
disulfonic acid,
2-amino-
1,5-N aphtha lene-
disulfonic acid,
3-amino-
1,5-Naphthalene-
disulfonic acid, 4-
amino-
1 ,5-Naphtnalene-
disulfonic acid, 4-
hydroxy-
1 ,5-Naphthalene-
disulfonic acid, 3-
nitro-
1,5-Naphthalene-
disulfonic acid, 4-
nitro-
1 ,6-N aphtha lene-
disulfonic acid
1 ,6-Naphthalene-
disulfonic acid,
8-amino-
1,6-Naphthalene-
disulfonicacid, 8-
hydroxy-
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg Toxicology
000086657 —
000118321 — —
000081049 — —
000117624 — —
000131271
000117555
000117566
000117862 — —
— — —
000525371 — —
000129919
000117431 — —
TLV Carcinogen
— —
—
—
— —
— —
—
— —
— —
— —
—
— —
—
378
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
15,41
15,39
15,37 — — — — 3)949
15,41
23d, 37
23d, 37
15,38
23d,37
23d,37
15,36
23c, 36
23c, 36
(Continued)
379
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
515
1,6-Naphthalene-
disulfonic acid,
8-nitro-
516
1,7-Naphthalene-
disulfonicacid, 4-
amino-5-hydroxy-
000130234
517
1,7-Naphthalene-
disulfonic acid, 4-
(benzoylamino)-5-
hydroxy-
006361495
518
2,6-Naphthalene-
disulfonic acid
000581759
519
2,6-Naphthalene-
disulfonic acid, 3-
amino-
006362045
520
2,6-Naphthalene-
disulfonic acid,
3-nitro-
521
2,7-Naphthalene-
disulfonic acid
000092411 —
522 2,7-Naphthalene-
disulfonic acid, 4-
acetamido-5-hydroxy-
000134349
523
2,7-Naphthalene-
disulfonicacid, 3-
amino-5-hydroxy-
000090404
524
2,7-Naphthalene-
disulfonic acid, 4-
amino-5-hydroxy-
000090200 —
525 2,7-Naphthalene-disul-
fonic acid, 4,4'-bis
(diethylaminobenzhydrol)
salt
826 2,7-Naphthalene-disul-
fonic acid, bis[(4-diethyl-
aminophenyDmethyl] salt
380
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year Uses References
23c, 36
23d, 37
23d, 37
15,35
23b, 35
23b, 35
15,35
23c, 36
NaOH Fusion 23g, 40
23c, 36
8, 17
35
8, 17 — — —
35
(Continued)
381
-------
TABLE B-2. (Continued)
Item
No.
527
Compound
Name and
Formula
2,7-Naphthalene-
disulfonicacid, 4-
chloro-5-hydroxy-
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg Toxicology
—
TLV Carcinogen
—
528 2,7-Naphthalene-
disulfonic acid, 4,5-
diamino-
529 2,7-Naphthalene-
disulfonic acid, 4,5-
dihydroxy-
000148254
530 2,7-Naphthalene-
disulfonic acid, 4,5-
dinitro-
531
2,7-Naphthalene-
disulfonic acid, 1-
hydroxy-
532
2,7-Naphthalene-
disulfonic acid, 3-
hydroxy-
000148754
533
2,7-Naphthalene-
disulfonic acid, 4-
nitro-
534
1-Naphthalene-
sulfonic acid
000085472
535
1-Naphthalene-
sulfonic acid, 2-
amino-
000081163
536
1-Naphthalene-
sulfonic acid, 4-
amino-
000084866 —
537
1-Naphthalene-
sulfonic acid, 5-
amino-
000084899
538
1-Naphthalene-
sulfonic acid, 6-
amino-
000081050 —
382
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses References
23c, 36
23c, 36
23c, 36
23b,35
Reduction 2,42
15,39
2,35
15,36
23g, 40
15,34
23d, 37
23h, 41
(Continued)
383
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) '-'•'RO' m^^ Toxicology TLV Carcinogen
539 1-Naphthalene- 000082757
sulfonic acid, 8-
amino-
540 1-Naphthalene- 000116632 —
sulfonic acid, 4-
am ino-3-hyd roxy-
541 1-Naphthalene- 000083647
sulfonic acid, 4-
amino-5-hydroxy-
542 1-Naphthalene- 006259638 — — — —
sulfonic acid, 4-amino-
3-hydroxy-7-nitro-
543 1-Naphthalene- 000082768
sulfonic acid, 8-
anilino-
544 1-Naphthalene-sul- — — — — —
fonic acid, 8-anilino-
5-(£-hydroxyanilino)-
545 1-Naphthalene-sul-
fonic acid, 4,5-
dihydroxy-
546 1-Naphthalenesulfonic 000567475 —
acid, 2-hydroxy-
547 1-Naphthalenesulfonic — — — — —
acid, 3-hydroxy-
548 1-Naphthalenesulfonic 000084871
acid, 4-hydroxy-
549 1-Naphthalenesulfonic 000117599 — — — —
acid, 5-hydroxy-
550 1-Naphthalenesulfonic 000132570 — —
acid, 7-hydroxy-
551 1-Naphthalenesulfonic 000117226
acid, 8-hydroxy-
552 1-Naphthalenesulfonic 052918293 —
acid, 8-[(methylphenyl)
amino]-
384
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10® kg/year Uses References
23d, 37 — — —
23g,40
23d, 37
23g,40
23d, 37
23d,37
23d,37
23g, 40 —
23g,40 — — —
23a,34
23d, 37 — — — —
23f, 39 — — — —
90- oo
^iJB, OO ^^^ — ^—— ——
23e, 38
(Continued)
385
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q' m9/k9 Toxicology TLV Carcinogen
553 1-Naphthalenesulfonic 017521005 —
acid, 5-nitro-
554 1-Naphthalenesulfonic — — — — —
acid, 8-nitro-
555 2-Naphthalenesulfonic 000120183 400 rat
(L66J
CSWQ)
acld (L66J
556 2-Naphthalenesulfonic —
acid, 6-acetamido-4-
hydroxy-
557 2-Naphthalenesulfonic 006334970
acid, 7-(acety!amino)-
4-hydroxy-
558 2-Naphthalenesulfonic 000119799
acid, 5-amino-
559 2-Naphthalenesulfonic 000093005
acid, 6-amino-
560 2-Naphthalenesulfonic 000494440
acid, 7-amino-
561 2-Naphthalenesulfonic 000119288
acid, 8-amino-
562 2-Naphthalenesulfonic —
acid, 7-[m-(4-aminobenz-
amidol-benzamido] -4-hydroxy-
563 2-Naphthalenesulfonic 000119777
acid, 7-(p-aminobenzamido)-
4-hydroxy-
564 2-Naphthalenesulfonic —
acid, 5-amino-6-hydroxy-
565 2-Naphthalenesulfonic 000090517
acid, 6-amino-4-hydroxy-
566 2-Naphthalenesulfonic 000087025
acid, 7-amino-4-hydroxy-
386
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
23d,37
23d, 37
15,35
2)776
23f, 39
23i, 42
23b, 35
23f, 39
23h, 39
15,41
23b, 35
Reduction 23i, 42
23i, 42
0.005/1974
Reduction 23g, 40
23h,41
23g, 40
23h, 41
(Continued)
387
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD,.-, mg/kg Toxicology TLV Carcinogen
567 2-Naphthalenesulfonic 000086453 — — — —
acid, 5-amino-6-methoxy-
568 2-Naphthalenesulfonic 000119197 — — — —
acid, 6-anilino-4-hydroxy-
569 2-Naphthalenesulfonic 000119404
acid, 7-anilino-4-hydroxy-
570 2-Naphthalenesulfonic 000132876
acid, 7-(benzoylamino)-
4-hydroxy-
571 2-Naphthalenesulfonic — — — — —
acid, 4,6-dihydroxy-
572 2-Naphthalenesulfonic 000097273
acid, 6,7-dihydroxy-
573 2-Naphthalenesulfonic — — — — —
acid, 6-ethoxy-
574 2-Naphthalenesulfonic — — — — —
acid, 6-ethoxy-5-nitro- >
575 2-Naphthalenesulfonic 000093016 LDLo:250 — — —
(\_6
HO)
acid, 6-hydroxy- (\_66J CSWQ m9/k9- mus
576 2-Naphthalenesulfonic —
acid, 4-hydroxy-7-(rn-
nitrobenzamido)-
577 2-Naphthalenesulfonic —
acid, 4-hydroxy-7-[m-
(£-nitrobenzamido)
nitrobenzamido] -
578 2-Naphthalenesulfonic 024431569
acid, 6-methoxy-
579 2-Naphthalenesulfonic —
acid, 6-methoxy-5-nitro-
580 2-Naphthalenesulfonic 000086691
acid, 5-nitro-
388
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
23f, 39
23h,41
23h,41
23i, 42
23f, 39
23f, 39
23g, 40
23g, 40
15,1 59 — — — — 2)777
23i, 42
5,19
24,42
23f, 39
23f, 39
23b, 35
(Continued)
389
-------
TABLE B-2. (Continued)
Item
No.
Compound
Name and
Formula
Chem. Abstr.
Registry No.
(WLN)
Oral Toxicity,
LD50, mg/kg Toxicology
TLV Carcinogen
581 2-Naphthalenesulfonic
acid, 8-nitro-
018425746
582 2-Naphthalenesulfonic
acid, 7,7'-ureylenebis
(4-hydroxy-
000134474
583 2-Naphthalenesulfonyl
chloride
000093118
584 1,4,5,8-Naphthalene-
tetracarboxylic acid
000128972
585 2-Naphthalenethiol
000091601
(L66JCSH)
LDLo:200 mg/kg,
ipr-mus
586
1,3,5-Naphthalene-
trisulfonic acid
006654644
587 1,3,5-Naphthalene- 017894994
trisulfonic acid, 8-amino-
588
1,3,5-Naphthalene-
trisulfonic acid, 8-
nitro-
589 1,3,6-Naphthalene-
trisulfonic acid
000086668
590 1,3,6-Naphthalene-
trisulfonicacid, 2-
amino-
591 1,3,6-Naphthalene-
trisulfonic acid, 8-
amino-
000117420 —
592
1,3,6-Naphthalene-
trisulfonicacid, 4-
hydroxy-
593
1,3,6-Naphthalene-
trisulfonicacid, 8-
hydroxy-
003316027 —
594 1,3,6-Naphthalene-
trisulfonic acid, 8-nitro
038267311
390
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
23b, 35 — — —
23i, 42
44,35
40, 15
44,35 — — — — 2)778
15,37
23d, 37
23d, 37
15,36
15,40
23c, 36
15,42
23c, 36
23c 36
(Continued)
391
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgQ, mg/kg Toxicology TLV Carcinogen
595 Naphthalic anhydride 000518058 —
596 Naphthalimide 000081834
597 Naphthalimide, N- 002382083
methyl-
598 2-Naphthamide, 3- 000092808
hydroxy-N-(2-hydroxy-
ethyl)-
599 2-Naphthamide, 3- 000132683
hydroxy-N-2-naphthyl-
600 2-Naphthamide, 3- — — — — —
hydroxy-N-2-naphthyl-
601 2-Naphthanilide, 4'- — — — — —
chloro-3-hydroxy-
602 2-Naphthanilide, 51- 000092728
chloro-3-hydroxy-2',
4'-dimethoxy-
603 2-Naphthanilide, 4'- 004273921
chloro-3-hydroxy-2',
5'-dimethoxy-
604 2-Naphthanilide, 3- 000092773 — — — —
hydroxy-
605 2-Naphthanilide, 3- — — —
hyd roxy-2-methoxy-6'-
methyl-
606 2-Naphthanilide, 3- 000135659 — —
hydroxy-3'-nitro-
607 2-Naphtho-o-anisidide, 000137520
5'-ch loro-3-hydroxy-
608 2-Naphtho^-anisidide, 000092795
3-hydroxy-
609 2-Naphthoic acid, 3- 005959524 — — — —
amino-
392
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
Oxidation 1,15 — — — — —
— 41,15
23f, 39
23a, 34
23h, 41
9a,27
40,63
20,33
23f, 39
14,31
25c, 45
18,32
9a, 27
23f, 39
(Continued)
393
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgg, mg/kg Toxicology TLV Carcinogen
610 2-Naphthoic acid, 3,5- 000089350 — — —
dihydroxy-
611 2-Naphthoic acid, 3- 000092706 800 mus
hydroxy- (L66J CVQ
DQ)
612 2-Naphthoic acid, 3- 000086646 — — —
hydroxy-5-sulfo-
613 2-Naphthol 000135193 2420 rat —
(L66JCQ)
614 1-Naphthol, 5-amino- 000083556 — —
615 1-Naphthol, 8-amino- 002834915 — — — —
616 2-Naphthol, 8-amino- — — — — —
617 1-Naphthol, 7-amino-3-sulfo-
(See 2-Naphthalenesulfonic acid, 6-amino-4-hydroxy-l
618 2-Naphthol, 5-amino- 000086975 —
619 2-Naphthol, 1-nitroso- 000131919
620 5-Naphthol, 1-amino-
(See 1-Naphthol, 5-amino-)
621 7-Naphthol, 1-amino-
(See 2-Naphthol, 8-amino-)
622 8-Naphthol, 1-amino-
(See 1-Naphthol, 8-amino-)
623 1-Naphthol-3-sulfonic acid, 6-amino-
(See 2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-)
624 1-Naphthol-3-sulfonic acid, 6-anilino-
(See 2-Naphthalenesulfonic acid, 7-anilino-4-hydroxy-)
625 2-Naphthol-6-sulfonic acid
(See 2-Naphthalenesulfonic acid, 6-hydroxy-)
394
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10® kg/year Uses References
— 23f, 39 — —
23f, 39 — — — — 2)779
15,39
1,35
23d, 37
23d, 35
23b, 35
1,40
(Continued)
395
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
626 2-Naphthol-8-sulfonic acid
(See 1-Naphthalenesulfonic acid, 6-hydroxy-)
627 Naphtho [2,1-6] th iophen- 000082600
1(2H)-one
628 2-Naphtho^o-toluidide, —
3'-ch loro-3-hydroxy-
629 2-Naphtho-o-toluidide, 000092762
4'-ch loro-3-hyd roxy-
630 2-Naphtho-o-toluidide, 000135615
3-hydroxy-
631 2-Naphtho-£-toludide,
3-hydroxy-
632 Napth-(1,2-d)1,2,3- 000233721
oxad iazo le-5-su If on ic
acid
633 1-Naphthylamine
025168109 779 rat
(L66J BZ)
USDS: CAR
Yes - incriminated
as cause os uninary
bladder cancer
TDLo:25 mg/kg/
TFX:NEO,scu-mus
634 1-Naphthylamine,
N-ethyl-
000118445
635 2-Naphthylamine
000091598 727 rat
(L66J CZ)
USDS: CAR
TDLo:31 gm/kg/
Yl
TFX:CARorl-rat
636 2-Phenazinol, 8-
amino-7-methyl-
LDLo:200 mg/kg
TFX:CAR ipr-mus
TDLo: 18 mg/kg
TFX:CAR par-mus
637 [3-Phenetidine
000156434
Recognized
carcinogen
638 m-Phenetidine, N,
N-diethyl-
396
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment ID** kg/year
Uses
References
44,35
29a,48
2b, 49
29a, 48
30.50
4,40
23a, 34
(Also 211,
Rof 1,
p523)
2)782
3)950
8,10,34
23g, 40
2)782
Oxidation
4,31
16,47
Reduction 45,29
25a,43
(Continued)
397
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgo/ mg/kg
Toxicology
TLV
Carcinogen
639 m-Phenetidine, 4-nitroso- 027292622
N,N-diethyl-
640 £-Phenetidine, 3-nitro- —
641 Phenetole,p-nitro- 000100298
642 Phenol, p>-N-acetylamino-
(See Acetanilide, 4'-hydroxy-l
643 PHenol, 4-N-acetylamino-2-nitro-
(See Acetamide, N-(4-hydroxy-2-nitrophenyl-)
644 Phenol, o-amino-
000095556
(ZR BQ)
LDLo:37 mg/kg
scu-cat
LD50:200 mg/kg
ipr-mus
645 Phenol, £-amino-
000123308 375 rat
(ZR DO)
LDLo:470 mg/kg
scu-mus
646 Phenol, 2-amino-4-
chloro-
000095852
647 Phenol, 2-amino-4-
chloro-6-nitro-
006358083
648 Phenol, 2-amino-4- 024133651
[ -dimethylbenzyl)-
649 Phenol, 2-amino-4,
6-dinitro-
000096913
650 Phenol, 4-amino-3-
(2-methylanilino)-
651 Phenol, 2-amino-4-
(methysulfonyl)-
000098306
652 Phenol, 2-amino-5-
nitro-
000121880
653 Phenol, 4-amino-2-
nitro-
000119346
398
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
25a, 43
9c, 29
— 9c, 29
Reduction 26,46
2)859
Reduction 27,47
2)859
Reduction 18,32
18,32
Reduction 26,46
Partial
Reduction
32,51
Reduction 29a, 48
31,51
Saponif ication 26, 46
27,47
(Continued)
399
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
654 Phenol, 2-amino-4-
(1,1,3,3-tetra-
methylbutyl)-
006073207
655 Phenol, 4-(4'-amino-
3'-toluidino)-
656 Phenol, m-anilino-
0000101188
657 Phenol, £-anilino-
000122372
658 Phenol, 2-chloro-4,
6-dinitro-
000946316 LDLo:500
(WNR BQ mg/k9 rat
CG ENW)
659 Phenol, 4-chloro-2,
6-dinitro-
000088879
660 Phenol, 2-chloro-4-
nitro-
000619089 LDLo:100
(WNR DQ
CG)
mg/kg rat
661
Phenol, 4-chloro-2
nitro-
000089645
662 Phenol, p-cyclohexyl- 001131608 -
663 Phenol, 2,4-diamino, 000095863
dihydrochloride
664 Phenol, 2,6-dibromo- 000099285 —
4-nitro-
665 Phenol, m-diethylamino- 000091689 —
666 Phenol, 4-( , -di- 024133640
methy Ibenzy I) -2-n itro
667 Phenol, 2,4-dinitro- 000051285 30 rat
(WNR BQ
ENW)
Phenol, m-nitro-
000554847 447 rat
(WNR CQ)
LDLo: 83 mg/kg,
ivn-dog
AOO
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
Reduction 26,46
31,51
35,60
20,33
9c, 29
2)861
18,32
9c, 29
2)861
18,32
31,51
Reduction 7e, 24
12,47
25a, 43
— 26,46
7e, 24 Emission factors:
hydrocarbon - 3.0,
NO2-1.0
25c, 45
0.45/1975
2)863
2)866
(Continued)
401
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
Phenol, o-nitro-
000088755
(WNR CQ)
2828 rat
LDLo: 100 mg/kg,
ivn-dog
670 Phenol, 2-nitro-
4-octyl-
024777057
671 Phenol, 4-nitroso-
000104916
(QR DNO)
LDLo:250 mg/kg,
ipr-mus
672 m-Phenylenediamine 000108452 LDLo:80
(ZRCZ) mg/kg, rat
Systemic poisoning
is uncommon
673 o-Phenylenediamine
000095545
(ZR BZ)
LDLo:600 mg/kg,
scu-rat
674 £-Phenylenediamine 000106503 LDLo: 100 £-isomer is most USOS air: TWA
(ZR DZ) mg/kg, rat toxic although 100 ug/m3 (skn)
systemic poisoning
is uncommon
675 m-Phenylenediamine, 4- 005131602
chloro-
676 o-Phenylenediamine, 4- 000095830
chloro-
677 m-Phenylenediamine, 2-chloro-5-sulfonic acid
(See Benzenesulfonic acid, 4-chloro-3,5-diamino-)
678 m-Phenylenediamine, 4- 000615054
methoxy-N (1 )-pheny I-
679 m-Phenylenediamine, 4- 000615054
methoxy-
680 m-Phenylenediamine, 4- 005131588
nitro-
681 Phthalic anhydride, 3- 000603112
nitro-
682 Phthalic anhydride, 4- 000610275
nitro-
402
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
7b, 21
2)866
26,46
31,51
2)866
Reduction 25c, 45
2)879
3)1013
40,23
2)879
3)1013
Reduction 9c, 29
2)880
3)1013
Ditto
7e, 24
Ditto
18,32
Ditto
18,32
Ditto
7c, 22
25c, 45
34a, 52
34a, 52
(Continued)
403
-------
TABLE B-2. (Continued)
Item
No.
683
Compound
Name and
Formula
Picric acid
Chem. Abstr.
Registry No.
(WLN)
000088891
(WNR BQ
CNW ENW)
Oral Toxicity,
LD5Q, mg/kg
LDLo:120
mg/kg, rbt
Toxicology
Can cause allergic
or irritative
dermatitis
TLV
USDS air: TWA
0.1 mg/k3
Carcinogen
—
684 Propionitrile, 3-
(N-acetanilino)-
685 Propionitrile, 3-
aninilo-
001075769
686 Propionitrile, 3-
(N-butylanilino)-
687 Propionitrile, 3-
(N-ethylanilino)
000148878
688 Propionitrile, 3- (p- 000094213
formyl-N-methyl-anilino)-
689 Propionitrile, 3-[(N- —
4-formyl-3-methylphenyl-
N-methyl)amino] -
690 Propionitrile, 3-(N-
methylanilino)-
000094348
691 Propionitrile, 3-[(N-
methy l-N-3-methy Ipheny I)
amino]-
692 2-Pyrazolin-5-one,1-[£-
ch loropheny l)-3-methy I-
693 2-Pyrazolin-5-one, 1- — — —
(5-chloro-o-tolyl)-3-
methyl-
694 5-Pyrazolone, 1-(4-chlorophenyl)-3-methyl-
(See 2-Pyrazdin-5-one, 1-(p-chlorophenyl)-3-methyl-)
695 5-Pyrazolone, 1-(2-chloro-5-sulfophenyl)-3-methyl-
(See Benzenesulfonicacid,£-chloro-3-(3-methyl-5-oxo-2-pyrazolin-1-yl-)
696 Pyrazolone, 1-(4-chloro-2-sulfophenyl)-3-methyl-
(See Benzenesulfonicacid, m-chloro-6(3-methyl-5-oxo-2-pyrazolon-1-yl-)
404
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
32,51 — — — — 3)1029
2)929
2a, 16
2a, 16
2b, 17
2b, 17
6,18
28,47
2c, 18
28,47
4,27
4,48
(Continued)
405
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
697 5-Pyrazolone, 1 (2,5-dichloro-4-sulfophenyl)-3-methyl-
(See Benzenesulfonic acid, 2,5-dichloro-4-(3-methyl-5-oxo-2-pyrazolin-1-yl-!
698 5-Pyrazolone, 3-methyl-1-(4-sulfophenyl)-
(See Benzenesulfonic acid, p>-(3-methyl-5-oxo-2-pyrazolin-1 -yl-)
699 Purpurin
(See Anthracenedione, 1,2,4-trihydroxy-9,10-)
700 4-Quinoneimine, N- — — —
(4-anilinophenyl)-
701 Resorcinol, 4-chloro- 000095885 — —
702 Salicylic acid, 5-amino 000089576
(ZR DQ CVQ)
LDLo:313 mg/kg,
ipr-mus
703 Salicylic acid, 5-nitro- 000096979
704 Sulfanilic acid
000121573
Animal experiments
suggest low toxicity
and slight irritation
705 Sulfanilic acid, N,
N'-dibenzyl
004986703
706 Sulfanilic acid, 2,
5-dichloro-
000088506
707 Sulfanilic acid, 2-nitro- 000712243
708 Sulfanilyl chloride, 000121608
N'acetyl (WSGRDMV1)
TDLo:5100ug/m3
ihl-hum
709 Sulfone, 4-chloro- 000097074
3-nitrophenyl methyl-
710 Sulfone, 2-chloro- 021081743
5-nitrophenyl methyl-
711 Sulfone, £-chlorophenyl 000098577
methyl-
712 o/Tolualdehyde,4-[(2- 000092104
chloroethyDethylamino] -
406
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 106 kg/year
Uses
References
19,33
12,63
Reduction 36,63
2)1043
36,63
Baking
15, 16
2a, 16
15,32
25c, 45
2a, 16
2.553/1974
2)1091
7b, 21
9a, 27
7a,20
30,50
(Continued)
407
-------
TABLE B-2. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
713 Toluene, m-chloro- 000108418
714 Toluene, o-chloro-
000095498
715 Toluene, p-chloro- 000106434
716 Toluene, 2-chloro- 000121868 3020 rat
4-nitro-
717 Toluene, 2-chloro-
6-nitro-
00083421
718 Toluene, 4-chloro-
2-nitro-
000089598
719 Toluene, 4-chloro-3- 000089601
nitro-
720 2,4-Toluenedisulfonic 000121040
acid
721 Toluene, 3-methoxy-
(See Anisole, m-methyl-)
722 Toluene, m-methoxy-
2-nitro-
723 Toluene, 4-methoxy-
3-nitro-
724 Toluene, o- , trichloro- 000088664
725 £-Toluenesulfonamide,
5-amino-
726 o-Toluenesulfonamide, 006269916
5-nitro-
727 p-ToluenesulfonamkJe;
N- [4-(5-hydroxy-2,7-naph-
thadenedisulfonic acid)] -
728 £-Toluenesulfonate, 8-
amino-3,6-disulfo-1-
naphthyl
408
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10** kg/year
Uses
References
28,47
39,62
12,60
12,50
2)1139
12,48
3,48
12,60
3,60
15,61
Nitration
14,31
15,31
12,62
Reduction 30,50
30,50
23c, 36
23c, 36
(Continued)
409
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q' m9/k9 Toxicology TLV Carcinogen
729 £-Toluenesulfonic acid, 000118887 — — — —
5-amino-
730 m-Toluenesulfonic acid, 000098339 — — — —
6-amino-
731 £-Toluenesulfonic acid, 000088539 — — — —
2-amino-5-chloro-
732 m-Toluenesulfonic acid, 000088517 — — — —
6-amino-4-chloro-
733 j>Toluenesulfonic acid, — — — — —
3-chloro-
734 £-Toluenesulfonic acid, — — — — —
3,5-diamino-
735 p-Toluenesulfonic acid, 000088904 — — —
3,5-dinitro-
736 m-Toluenesulfonic acid, 000101111 — — — —
-(N-ethylanilino)-
737 o-Toluenesulfonic acid, 000121039 — — — —
5-nitro-
738 £-Toluenesulfono-£- 000599860 — — — —
toluidide,
739 £-Toluenesulfono-£- — — — — —
toluidide, 2'-nitro-
740 £-Toluenesulfonyl — — — — —
chloride, 3-chloro-
741 o-Toluenesulfonyl 000121028 — — —
chloride, 5-nitro-
742 o-Toluenethiol, 4-chloro-017178017 — — —
A10
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
Reduction 30,50
Baking
15.50
Reduction 39,62
Baking
15,50
12,61,62
Reduction 38,61
38,61
15,17
5,15,50
3.431/1974
30,50
30, 50
12,62
30,50
Reduction 28,47
(Continued)
411
-------
lABLtB-2. (Continued)
Compound
Item Name and
No. Formula
743 m-Toluidine
Chem. Abstr.
Registry No.
(WLN)
000108441
(ZRC)
Oral Toxicity,
LDgg, mg/kg Toxicology
974 rat Material can produce
severe systemic
disturbances, although
good data for com-
paring the o-, m-, and
p isomers are not
available
TLV
USOS air: TWA
5 ppm
USOS air: TWA
22 mg/m3
Carcinogen
A recognized
carcinogen
744 o-Toluidine
000099945
(ZRB)
Material can pro-
duce severe sys-
temic disturbances,
although good
data for comparing
the p_, m, and £
isomers are not
available
USOS air: TWA
5 ppm
USOS air: TWA
22 mg/m3
A recognized
carcinogen
745 p-Toluidine
000106490
(ZRD)
Material can pro-
duce severe sys-
temic disturbances,
although good data
for comparing the
c), m, and £ isomers
are not available
USOS air: TWA
5 ppm
USOS air: TWA
22 mg/m3
A recognized
carcinogen
746 m-Toluidine, N-
benzyl-N-ethyl-
000119948
747 o-Toluidine, 3-chloro- 000087605
748 p-Toludine, 3-chloro- 000097549 1500 rat
(ZR CG D)
749 o-Toluidine, 4-chloro- 000095692 —
750 o-Toluidine, 5-chloro- 000095794 464 rat
(ZR CG F)
LDLo:310 mg/kg,
scu-cat
751 p-Toluidine, N-(2-
chloroethyl)-N-ethyl-
752 £-Toluidine, 4-chloro-
5-nitro-
753 o-Toluidine, 5-(N,N-
diethylamino)-
412
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
Reduction
28,47
2)1142
3)22
1175-6
Ditto
19,48
2)1142
3)22
1175-6
Ditto
30.50
Ditto
— 4,47
45,48
30,50
2)1143
Saponification 29b, 49
Reduction
29a, 48
2)1143
30,50
— 29b, 49
29b,49
(Continued)
413
-------
TABLE B-2. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) L^5(y m9/k9 Toxicology TLV Carcinogen
754 m-Toluidine, N-ethyl- 000102272 —
755 m-Toluidine, N-methyl- 000696446 — — — —
756 £-Toluidine, 4-methoxy- — — — — —
5-nitro-
757 p-Toluidine, 2-nitro- 000089623
758 £-Toluidine, 3-nitro- 000119324 3 bdw — — —
(ZR D CNW)
759 o-Toluidine, 4-nitro- 000099523 — —
760 £-Toluidine, 6-nitro- 000570241 — — — —
761 Trimellitic acid, 5-amino
(See 1,2,4-Benzenetricarboxylic acid, 5-amino-)
762 Trimellitic acid, 5-hydroxy-
(See 1,2,4-Benzenetricarboxylic acid, 5-hydroxy-)
763 Trimellitic acid, 5-nitro-
(See 1,2,4-Benzenetricarboxylic acid, 5-nitro-)
764 2,4'-Xylidine 000095681 467 rat
(ZR B D)
414
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 106 kg/year
Uses
References
28,47
28,47
29b, 49
30,50
30,50
2)1144
29b, 49
29a, 48
29a, 48
Reduction
42,63
2)1202
415
-------
TABLE B-3. ORGANIC DYES AND PIGMENTS-TOXICITY
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
C110005 Mordant G reen 4
CI10006 Pigment
Green 8
015635537
Cl 10020 Acid
Green 1
019381501
Cl 10020 D&C
Green 8
006358696
5 Cl 10316 Ext. D&C 000846708
Yellow 7
CI10316Acid
Yellow 1
000846708
CM0338 Disperse
Yellow 42
005124254
8 Cl 10345 Disperse
Yellow 1
000119153
9 Cl 10395 Acid
Brown 1
10 CM 1000 Solvent
Yellow 1
000060093
(ZR DNUNR)
TDLo:1600
mg/kg/2.3YI
TFX:CAR, skn-rat
11 CM 1000 Pigment
Yellow 98
416
-------
PROCESS, WASTE, PRODUCTION AND DATA
Process
(Sources Process
of Compound) No.
Associated Wastes
Waste
Treatment
Total
Production
103 kg/year
Uses
References
Nitrosation 1 Air: nitrogen oxide
Filtration Water: inorganic
salt solutions
Nitrogen oxide
fumes escape
from a tall stack
or pipe. Usually
no effort has been
made to control
fluid effluents
Ditto
Ditto
Ditto
67.3/1973
Nitrosation
Filtration
Precipitation
1 Air: nitrogen oxide
18 Water: inorganic
salt solutions and
brines which may
contain residual
amounts of metal
ions
Ditto
See Item 3
Air: nitrogen oxide Nitrogen oxides 404/1973
Water: inorganic are difficult to
salt solutions and control by water
nitrogen oxides scrubbing
Ditto
Ditto
Ditto
Replacement
Reaction
Filtration
Water: brine con-
taminated with
small amounts of
organic substances
Ditto
Ditto
Ditto
Diazotization
Coupling
Water: inorganic
salts
53.6/1973
2)29,
Splmnt
Ditto
Ditto
(Continued)
417
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
12 CI11005 Disperse
Orange 3
000730405
13 CM 1014 Basic Red 30
14
CM 1020 Solvent
Yellow 2
000060117 800 rat
(1N1&R
DNUNR)
TDLo: 800 mg/kg/
40D,TFX:CAR
orl-rat
TDLo: 11 gm/kg/
12WC,TFX:NEO
orl-mus
15
CM 1021 Solvent
Yellow 56
002481949 300 mus
16 CI11043 Basic
Violet 18
17 CI11052 Basic Blue 54 015000596
18 CM 1085 Basic Red 18 014097031
19 CI11100 Disperse
Orange 5
006232560
20 C111110 D isperse Red 1 002872528
21
CM 1115 Disperse
Red 13
003180812
22 Cl 11150 Disperse Red 7 004540005
23 CM 1152 Disperse
Brown 1
24 CI11154 Basic Blue41
25
CM 1160 Solvent
Yellow 3
000097563
26
CM 1210 Disperse
Red 17
003179893
27 CI11215 Disperse
Red 5
00376951
418
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
Ditto
Ditto
4
4
Ditto
Ditto
2)330, 108
Ditto
Ditto
39.6/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
4
4
4
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
254/1973
160/1973
Ditto
Ditto
123/1973
Ditto
Ditto
— 46.4/1973
(Continued)
419
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
28 CI11250 Disperse
Red 31
002475436
29 CM 1255 Disperse
Black 2
006232571
30 CM 1270 Basic
Orange 2
000532821 LDLo:158mg
(ZR CZ m9/k9' mus
DNUNR &GH)
TDLo:158mg/kg/
56WC,TFX:NEO
orl-mus
31
CI11290 Mordant
Brown 12
32
CI11320 Basic
Orange 1
005042546
33
CM 1365 Disperse
Black 1
00605484
34
CI11450 Basic
Yellow 25
041025676
35
CI11460 Basic Red 29
36
CI11480 Basic
Yellow 24
37 CI11660 Pigment
Yellow 5
38 CM 1665 Pigment
Yellow 4
001657165
39 CM 1670 Pigment
Yellow 6
004106767
40 CM 1680 Pigment
Yellow 1
002512290 —
41 CI11710 Pigment
Yellow 3
006486233 —
42
CM 1720 Pigment
Yellow 9
420
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
Ditto
Ditto
Ditto
Ditto
221/1973
2)881,330
Ditto
Ditto
Ditto
Ditto
142/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
— 306/1973
Ditto
Ditto
Ditto
Ditto
189/1973
Ditto
Ditto
421
(Continued)
-------
TABLE B-3. (Continued)
Item
No.
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
Compound
Name and
Formula
CM 1725 Pigment
Orange 1
CM 1738 Pigment
Yellow 73
CI11 740 Pigment
Yellow 65
CM 1741 Pigment
Yellow 74
CM 1765 Pigment
Yellow 49
CM 1767 Pigment
Yellow 97
CM 1770 Pigment
Yellow 75
CI11 855 Disperse
Yellow 3
CI11 920 Solvent
Orange 1
Cl 12055 Solvent
Yellow 14
Cl 12060 Pigment
Orange 2
CM 2070 Light
Pigment Red 1
CM 2071 Pigment
Brown 2
Cl 12075 Pigment
Orange 5
CI12075D&C
Orange 17
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50' m9/k9 Toxicology
006371966
—
—
— —
—
012225182
—
002832408
002051856 — —
000842079
(L66J
BNUNR&CQ)
006410099 — —
006410102 — —
—
003468631 — —
003468631
TLV Carcinogen
—
—
—
—
—
—
—
—
—
— TDLo:56gm/kg/
52WC, TFX:NEO
orl-mus
—
—
—
—
—
422
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
Ditto
Ditto
290/1973
Ditto
4 Ditto
Ditto
4 Ditto
Ditto
4 Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
1704/1973
Ditto
Ditto
Ditto
Ditto
256/1973
2)780, 330
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
364/1973
Ditto
Ditto
423
(Continued)
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
58 CM2085 D&C Red 36 002814779
59 Cl 12085 Pigment
Red 4
002814779
60 Cl 12090 Pigment Red 6 006410135
61
CI12100 Solvent
Orange 2
002646175 LDLo:500
(L66J mg/kg. rat
BNUNR
B&CQ)
TDLo:6mg/kg/
52W,TFX:CAR
scu-mus
62 CI12120 Pigment Red 3 002425856
63
CI12140 Solvent
Orange 7
003118976
(L66J BNUNR
B D & CQ)
TDLo:80 mg/kg
TFX:NEO imp-mus
64 CI12150 Solvent Red 1 001229556
65
CI12170 Pigment
Red 40
002653647
66 Cl 12200 Mordant —
Black 19
67 C11210 Basic Blue 16 004569884
68 CM2245 Direct Red 001325639
76
69 CI12310 Pigment
Red 2
006041947
70 Cl 12315 Pigment
Red 22
006448959
71 Cl 12350 Pigment
Red 18
003564225
72 CI12355 Pigment
Red 23
006471494
424
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment TO"* kg/year
Uses
References
Diazotization
Coupling
Ditto
Water: inorganic
salts
Ditto
5.0/1973
135/1973
Ditto
Ditto
4 Ditto
4 Ditto
2)330, 781
Ditto
Ditto
4
4
Ditto
Ditto
814/1973
35.5/1973
2)330, 781
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
35.5/1973
Ditto
Ditto
58.6/1973
Ditto
Ditto
Ditto
Ditto
122/1973
(Continued)
425
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
73
CM2360 Pigment
Red 31
74 CI12370 Sodium
Pigment Red 112
006535462*
75 Cl 12370 Pigment
Red 112
006535462
76 Cl 12380 Pigment
Red 14
77
Cl 12390 Pigment
Red 17
006655841
78 Cl 12395 Pigment
Red 13
79
CI12420 Pigment
Red 7
006471518
80
Cl 12440 Pigment
Red 10
006410351
81
Cl 12460 Pigment
Red 9
006410384
82 Cl 12465 Pigment
Red 15
83
CM2480 Pigment
Brown 1
006410408
84 CM2485 Pigment
Red 146
85
CI12490 Pigment
Red 5
006410419
86 CI12515 Pigment
Red 176
87 Cl 12690 Disperse
Yellow 8
006358492 —
426
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
36.8/1973
Ditto
Ditto
Ditto
4 Ditto
Ditto
4 Ditto
Ditto
4 Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
45.5/1973
Ditto
Ditto
Ditto
Ditto
427
(Continued)
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
88 Cl 12710 Pigment
Yellow 10
006407756
89 CI12715 Solvent Red 8
90 Cl 12775 Pigment
Green 10
006421654
91 CM2790 Disperse
Yellow 5
006439538
92 CI13010 Acid Dye 0
93 CM3025 Acid
Orange 52
000547580
94 C113058 D&C Red 39 063715571
95 CI13065 External D&C 000587984
Yellow 1
96 Cl 13065 Acid Yellow 000587984
36
97 CI13080 Acid Orange 000554734
5
98 Cl 13090 Acid Orange
1
99 CM 3095 Acid
Yellow 63
100 CI13150Acid
Orange 50
101 CM3225 Mordant
Brown 13
006054804
102 CM3250 Mordant
Brown 33
003618620 —
103 CM3265 Mordant
Brown 49
428
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
89.6/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
(Continued)
429
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
104 Cl 13360 Mordant
DyeO
105 Cl 13361 Acid Green
35
106 CI13390 Acid Blue 92 003861732
(L66J BQ DS-
WQ HSWQ JNUN
BL66J EMR&
GSWQ &-NA- 3)
LD50:450 mg/kg.
107 CI13425 Acid Green 12
108 CM3900 Acid
Yellow 99
010343585
109 CM3900 Solvent
Yellow 19
010343585*
110 CL13906 Acid
Yellow 151
111 CI13920 Direct
Yellow 8
112 CI13950 Direct
Yellow 27
113 Cl 14025 Mordant
Yellow 1
000584429
114 Cl 14030 Mordant
Orange 1
001718349 —
115 CI14055 Mordant
Yellow 14
116 Cl 14110 Mordant
Yellow 20
117 CI14130 Mordant
Yellow 5
006054984
118 CI14135 Mordant
Yellow 36
430
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
Ditto
Ditto
Ditto
Ditto
35.5/1973
2)330. 773
Ditto
Ditto
Ditto
Ditto
42.3/1973
Ditto
Ditto
Ditto
Ditto
818/1973
Ditto
Ditto
10.9/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
(Continued)
431
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
119
CI14155 Direct
Green 28
006471096
120 CI14170Acid
Yellow 65
121 Cl 14250 Mordant
Brown 19
122 Cl 14270 Acid
Orange 6
000547579 —
123 Cl 14625 Acid
Brown 6
006409105 —
124 CI14640 Mordant
Black 3
003564145
125
Cl 14645 Mordant
Black 11
001787617
126 C114700 F D&C Red 4 004548532
(L66JBQ
CNUNR B D
ESWO& ESWO
&-NA- 2)
— TDLo:428 mg/kg/
65WC,TFX:CAR
orl-rat
127 CI14710 Acid Red4 005858399 —
128 CI14720 AckJ Red 14 003567699
(L66J BSWQ
ENUN-CL66J
BQESWG
&-NA-2)
LD50:900 mg/kg,
ipr-rat
129 CM 4830 Calcium
Pigment Red 54
130 CM 4856 Mordant
Blue 9
003624688 —
131 CM4870 Mordant
Brown 15
008006028 —
132 Cl 14880 Acid Blue 158
432
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Ditto
4 Water: inorganic
salts
Ditto
24.1/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
2)330, 778
Ditto
Ditto
4 Ditto
4 Ditto
69.6/1973
60.0/1973
2)330, 777
Ditto
Ditto
34.6/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
540/1973
(Continued)
433
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgQ, mg/kg Toxicology TLV Carcinogen
133 CI15050 Acid Blue 158 — — — —
134 CI15075 Direct 005850737
Red 20
135 CI15510Acid 000633965
Orange 7
136 CI15510 Lake Pigment 000633965*
Orange 17
137 CM5510 D&C 000633965
Orange 4
138 CI15575Acid 005850862
Orange 8
139 CI15585 Sodium 002092560
Pigment Red 53
140 Cl 15585 Barium 002092560*
Pigment Red 53
141 CM5585 D&C 024777239 —
Red 9
142 Cl 15585 D&C Red 8 002092560
143 Cl 15620 Acid Red 88 001658566
144 Cl 15630 D&C Red 10 001248186 —
145 Cl 15630 D&C Red 13 006371671
146 CM5630 D&C Red 12 001103384
147 CI15630D&CRed11 001103395
148 CI15630 Sodium 001248186
Pigment Red 49
149 Cl 15630 Calcium 001103395
Pigment Red 49
434
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Ditto
Water: inorganic
salts
Ditto
540/1973
Ditto
Ditto
— 257/1973
Ditto
Ditto
Ditto
Ditto
2.27/1973
Ditto
Ditto
125/1973
Ditto
Ditto
Ditto
Ditto
1445/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
458/1973
1.8/1973
6.8/1973
Ditto
Ditto
— 634/1973
(Continued)
435
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
150 CM5630 Barium
Pigment Red 49
001103384 —
151 CM 5670 Mordant
Violets
002092559
152 Cl 15705 Mordant
Black 17
002538854
153 Cl 15710 Mordant
Black 1
003618584 —
154 CI15711Acid
Black 52
005610640
155 CM5800 Pigment
Brown 5
027757795* —
156 CI15800D&CRed31 027757795*
157 Cl 15800 Pigment
Red 64
027757795
158 Cl 15820 Pigment
Red 55
027873627
159 Cl 15825 Pigment
Red 58
025310978
160 CM5826 Pigment
Red 77
161 CM5850 Calcium
Pigment Red 57
005281049 —
162 CI15850D&C Red 7 005281049
163 CI15850 D&C Red 6 005858811
164 Cl 15860 Pigment
Red 52
005858822 —
165 Cl 15865 Pigment
Red 48
016013448
436
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Ditto
Water: inorganic
salts
Ditto
— 1997/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
385/1973
Ditto
Ditto
63.6/1973
Ditto
Ditto
Ditto
Ditto
Ditto
4 Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
— 717/1973
Ditto
Ditto
Ditto
4
4
4
Ditto
Ditto
Ditto
27.3/1973
Ditto
Ditto
— 1505/1973
437
(Continued
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
166 Cl 15880 Pigment
Red 63
021416466
167 CM5880 D&C Red 34 021416466*
168 CI15970Acid
Orange 12
001934209
169 CM5985 D&C
Yellow 6
002783940
(L66J BNUNR
DSWQ& CQ
HSWQ &-NA- 2)
LD50:3800mg/kg,
ipr-rat
TDLo:2750mg/kg/
28WI,TFX:NEO
scu-rat
170 CI15985FD&C
Yellow 6
Ditto
Ditto
Ditto
171 CI15995Acid
Orange 31
172 CM6055 Acid
Violet 56
173 CI16105Lake
Pigment Red 60
001836222* —
174 Cl 16105 Mordant
Red 9
001836222
175 C116150 Acid Red 26 003761533
176 CI16180 Acid Red 17 005858333
177 CI16185 Acid Red 27 000915673
(L66J BSWQ
ENUN-BL66J
CQ DSWQ
HSWQ &-NA- 3)
LDLo:1500ug/kg/
(preg),TFX:TER
orl-rat
LD50:1000mg/kg
ipr-rat
TDLo:172gm/kg
26WC,TFX:CAR
orl-rat
178 CI16185FD&CRed2 00915673
Ditto
Ditto
179 CI16185D&CRed2 00915673*
180 CI16230Acid
Orange 10
001936158
438
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
20.9/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
2)330, 777
Ditto
Ditto
473/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
155/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
15.5/1973
2)330, 774
Ditto
Ditto
Ditto
Ditto
576/1973
2)330, 774
Ditto
Ditto
117/1973
(Continued)
439
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
181 CI16255 Acid Red 18 002611827
(L66JCO
HSWO JSWO
BNUN-)
LD50:600 mg/kg,
ipr-rat
TDLo: 524 mg/kg/
74WC,TFX:CAR
orl-rat
182 Cl 16260 Acid
Violet 58
(BL66J ESWO
&-NA- 4)
183 Cl 16260 Solvent
Red 35
184 CM6500 Mordant
Black 9
000548801
185 CI16575 Acid Red 176 004682477
186 CM6580 Acid
Violet 3
001681603
187 Cl 16600 Acid
Violet 6
004197095 —
188 CM 7025 Acid
Violet 1
189 CI17045 Acid Red 37 006360072
190 CI17065 Acid Red 32
191 CI17200 Acid Red 33 003567666
192 CI17200D&CRed 33 003567666
193 CM 7235 Mordant
Green 36
003769617
194 CM 7590 Mordant
Brown 40
195 Cl 17755 Acid Red 137 006222635
196 CI17757 Reactive
Orange 16
440
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
63.6/1973
2)330, 777
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
17.7/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
Ditto
Ditto
Ditto
Ditto
Ditto
— 28.6/1973
Ditto
Ditto
Ditto
Ditto
59.1/1973
Ditto
Ditto
(Continued)
441
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgo, mg/kg Toxicology TLV Carcinogen
197 CI17820 Direct — — — —
Red 123
198 Cl 17908 Reactive 025489365 —
Red 8
199 CI17916 Reactive 012236770 — — — —
Black 1
200 Cl 17995 Acid Red 133 006417363 — — —
201 Cl 18050 Acid Red 1 003734676 — — — —
202 CI18055Acid 004321691
Violet 7
203 CI18065 Acid Red 35 006441936 —
204 Cl 18073 Acid Red 138 — — — — —
205 Cl 18075 Acid
Violet 12
206 Cl 18096 Reactive — — — —
Violet 4
207 Cl 18097 Reactive 012226389 — — — —
Violet 5
208 CM8105 Reactive 015623662 — — — —
Red 4
209 CI18110Acid Red 106 — — — —
210 CI18158 Reactive 017752851 — — — —
Red 1
211 CI18159 Reactive 023211474
Red 3
212 CMS 160 Mordant 000641969
Black 38
213 CI18165Acid 012218950 —
Black 60
442
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Ditto
Water: inorganic
salts
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
— 207/1973
— 90/1973
Ditto
Ditto
Ditto
4
4
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
(Continued)
443
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
214 CI18690Acid
Yellow 121
215 Cl 18695 Acid
Yellow 4
216 CM8710 Mordant
Yellow 30
014904519 —
217 CI18732Acid
Orange 60
218 CI18740Acid
Orange 72
219 CI18745Acid
Orange 74
010127272
220 Cl 18745 Solvent
Orange 5
010127272*
221 CM8760 Mordant
Red 7
003618631
222 CI18761 Acid Red 201
223 Cl 18800 Acid Red 183 006408317
224 CI18810 Acid Red 186 052677448
225 CI18820Acid
Yellow 11
006359826
226 Cl 18821 Mordant
Yellow 8
227 C118835 Acid
Yellow 25
006359859
228 Cl 18850 Acid
Yellow 25
025739677
229 Cl 18870 Acid
Orange 76
444
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
148/1973
Ditto
4 Ditto
Ditto
4 Ditto
40.0/1973
Ditto
4 Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
Ditto
Ditto
Ditto
33.2/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
(Continued)
445
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
230 Cl 18890 Acid
Yellow 34
231 Cl 18900 Acid
Yellow 29
006359917
232 Cl 18940 Mordant
Orange 4
006359962
233 C118950 Acid
Yellow 40
006372969
234 CI18960Acid
Yellow 14
235 CI18965Acid
Yellow 17
006359984
236
Cl 18990 Reactive
Yellow 13
237
Cl 19010 Acid
Yellow 54
010127056
238
CI19140 Acid
Yellow 23
001934210
239 CI19140D&C
Yellow 5
001934210*
240
CI19140FD&C
Yellow 5
001934210
241 Cl 19350 Mordant
Dye 1
242 CI19351 Acid Red 179
243 CI19540 Direct
Yellow 9
001829001
244 CI19555 Direct
Yellow 28
008005729
245
CM9556 Direct
Yellow 29
006537662
446
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salt
40.0/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
117/1973
Ditto
Ditto
Ditto
Ditto
149/1973
Ditto
Ditto
26.3/1973
Ditto
Ditto
Ditto
Ditto
287/1973
Ditto
Ditto
Ditto
Ditto
626/1973
Ditto
Ditto
Ditto
Ditto
4
4
Ditto
Ditto
Ditto
Ditto
93.2/1973
Ditto
Ditto
(Continued)
447
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abjtr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
246 CM9600 Mordant
Brown 21
006232515
247 CI20040 Pigment
Yellow 16
005979282
248 CI20110 Mordant
Brown 1
003654156
249 CI20150 Mordant
Brown 18
250 C120170 Acid
Orange 24
001320076
251 CI20195 Acid
Brown 14
252 CI20440 Acid
Green 19
005850340
253 CI20460 Acid Blue 29
254 CI20470 Acid
Black 1
000106448
255 CI20480 Acid
Black 41
256 CI20495 Acid
Green 20
005850395
257 CI20505 Reactive
Black 5
012225251
258 C121000 Basic
Brown 1
010114586
259 CI21010 Basic
Brown 4
005421669
260 CI21010 Pigment
Brown 3
005421669*
261 CI21010 Solvent
Brown 12
005421669*
448
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment lO"* kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
Ditto
Ditto
Ditto
Ditto
14.6/1973
Ditto
Ditto
Ditto
Ditto
210/1973
Ditto
Ditto
— 127/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
357/1973
Ditto
4 Ditto
Ditto
Ditto
10.9/1973
Ditto
Ditto
Ditto
Ditto
59/1973
Ditto
Ditto
235/1973
Ditto
Ditto
Ditto
Ditto
9.1/1973
449
(Continued)
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q, mg/kg Toxicology TLV Carcinogen
262 CI21030 Basic Brown 2 — — — — —
263 CI21090 Pigment 006358856
Yellow 12
264 CI21095 Pigment 005468757 — — — —
Yellow 14
265 CI21096 Pigment
Yellow 55
266 CI21100 Pigment 005102830 — — — —
Yellow 13
267 CI21105 Pigment 004531491
Yellow 17
268 CI21108 Pigment 005567157
Yellow 83
269 CI2110 Pigment 003520727 — — —
Orange 13
270 CI2115 Pigment — — — — —
Orange 34
271 CI21120 Pigment Red 38 006358878 — — — —
272 CI21130 Pigment — — — —
Orange 15
273 CI21160 Pigment — —
Orange 16
274 CI21165 Pigment — — — —
Orange 14
275 CI21180 Pigment Blue 25 024876322 — —
276 CI21200 Pigment Red 41 006505299 — — — —
277 C121230 Solvent 010127034
Yellow 29
278 CI21240 Solvent 003321106 — —
Yellow 30
450
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10~* kg/year
Uses
References
Diazotization
Coupling
Ditto
Water: Inorganic
salts
Ditto
3.817/1973
Ditto
Ditto
1.225/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
261/1973
Ditto
Ditto
Ditto
Ditto
— 149/1973
Ditto
Ditto
40.9/1973
Ditto
Ditto
4
4
Ditto
Ditto
Ditto
Ditto
171/1973
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
Ditto
Ditto
Ditto
Ditto
Ditto
IfVintinnprt)
451
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN)
LD5Q, mg/kg
Toxicology
TLV
Carcinogen
279 CI21250 Solvent Red 22 006706758
280 CI22120 Direct Red 28 000573580
(L66J B2
ESWQCNUNR
D2 &-NA- 2)
TDLo:80 mg/kg/
(8D preg) TFX:
TER unk-rat
LD50:190 mg/kg,
ivn-rat
281 CI22130 Direct
Orange 8
002429701
282 CI22140 Direct
Orange 8
283 CI22145 Direct Red 10 002429701
284 CI22155 Direct Red 13 001937355
285 CI22165 Direct Dye 0
286 CI22195Acid 002429803
Orange 45
287 CI22240 Direct Red 37 — —
288 CI22245AcidRed85 003567655
289 CI22310 Direct Red 1 002429847
291 CI22345 Direct
Brown 59
003476902
292 CI22370 Direct Orange 1 — —
293 CI22375 Direct Orange 1 — —
294 CI22410 Direct
Yellow 20
295 CI22430 Direct Orange 1
296 CI22460 Direct Violet 27 — —
297 CI22480 Direct Violet 22 006426671 —
452
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Ditto
Water: inorganic
salts
Ditto
136/1973
Ditto
Ditto
Ditto
Ditto
60.0/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
60.5/1973
76.8/1973
90.9/1973
67.3/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
(Continued)
453
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgo, mg/kg Toxicology TLV Carcinogen
298 CI22570 Direct Violet 1 002586609
299 CI22590 Direct Blue 2 002429734
300 CI22870Acid
Orange 63
301 CI22880 Mordant 006232491
Yellow 26
302 CI22890 Acid Red 97 —
303 CI22895Acid
Orange 56
304 CI22910Acid 006375559
Yellow 42
305 C123050 Direct Red 46 — —
306 CI23155 Direct Blue 98 006656037
307 CI23266 Acid Red 111 006358572 —
308 CI23285 Acid Red 99 003701404
309 CI23365 Direct — —
Orange 6
310 C123370 Direct
Orange 10
311 CI23375 Direct — —
Orange 6
312 CI23500 Direct Red 2 000992596 —
313 C123630 Direct Red 39
314 CI23635 Acid Red 114 006459945 —
315 CI23790 Direct Blue 25 002150541
454
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
Water: inorganic — — — —
salts
Ditto — 540/1973
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — 29.6/1973
Ditto — — — —
Ditto — 152/1973
Ditto — — — —
Ditto — 61.4/1973
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — 96.4/1973
Ditto — 56.8/1973
Ditto — 255/1973
Ditto — 22.3/1973 —
(Continued)
455
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
316 CI23850 Direct Blue 14 000072571
(L66J BQ
DSWQ
HSWQ JZ
CNUNR B
D-2&-NA-4)
TDLo:25 mg/kg/
(8Dpreg),TFX:
TER scu-mus
LD50:267 mg/kg,
scu-mus
TDLo:825 mg/kg/
65WI,TFX:CAR
scu-rat
317 C123900 Acid
Yellow 44
002429767
318 CI23910Acid Red 89 006472500
319 C124065 Direct Blue 136
320 CI24100 Direct Red 7 002868759
321 CI24125AcidRed 128
322 CI24140 Direct Blue 8 002429712
323 CI24175 Direct Blue 151 006449350
324 CI24280 Direct Blue 22 002586574
325 CI24400 Direct Blue 15 002429745 —
326 CI24401 Direct Blue 218
327 CI24410 Direct Blue 1 002610051
328 CI24411 Direct Blue 76 016143796
329 CI24810 Acid Red 134 006459694
330 CI24890 Direct
Yellow 4
003051114 —
331 CI24895 Direct
Yellow 12
002870328
332 CI25040 Direct Black 71
333 CI25100 Mordant
Yellow 16
456
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic
salts
2)330, 774
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
4
4
4
4
4
4
4
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
20.0/1973
669/1973
117/1973
35.9/1973
— 273/1973
91.4/1973
(Continued)
457
-------
TABLEB-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) '-'-'
50'
Toxicology
TLV
Carcinogen
334 C 1 25 135 Acid
Yellow 38
335 CI25200 Direct Orange 73
336 CI25275 Direct Red 120
337 CI25300 Direct
Yellow 26
002829427
338 CI25380 Direct Red 75 002829438
339 CI25400 Direct Violet 62 007198994
340 CI25410 Direct Violet 47
341 CI26070 Disperse
Yellow 23
006250233
342 CI26100D&C Yellow 17 000085869
343 CI261 05 Solvent Red 24 000085836
(L66JBNUNRB
DNUNR B&& CQ)
TDLo:512 mg/kg/
58WI,TFX:CAR
scu-rat
344 CI261 20 Solvent Red 26 004477796
345 CI26125 Solvent Red 27 001320065 —
346 CI26150 Solvent
Black 113
004197255
347 CI26207 Acid Red 350 —
348 CI26360 Acid Blue 113 003351051
349 CI26370Acid
Black 24
003071736 —
350 CI26400 Acid Blue 120 003529019
351 CI26410 Acid Blue 118 006406322
458
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Ditto
Ditto
Ditto
Water: inorganic
salts
Ditto
Ditto
Ditto
55/1973
41.4/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
14.6/1973
96.8/1973
339/1973
Ditto
Ditto
4
4
Ditto
— 96.8/1973
2)330, 781
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
93.6/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
382/1973
Ditto
Ditto
Ditto
Ditto
46.8/1973
(Continued)
459
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgg, mg/kg Toxicology TLV Carcinogen
352 CI26520 Mordant 003564270
Orange 6
353 CI26550 Acid Orange 51
354 CI26900 Acid Red 151
355 CI26905 Acid Red 66 004196990
356 CI27070 Acid Black 26
357 CI27075 Acid Black 26
358 CI27200 Acid Red 115 006226808
359 CI27290Acid Red 73 005413752
360 CI27680 Direct Red 16 006227027 — — —
361 CI27700 Direct Black 17 002945962
362 CI27720 Direct Black 51 034977634 — — — —
363 CI27855 Direct Violet 7
364 CI27885 Direct Violet 9 006227141
365 CI27905 Direct Violet 51 005489770 — — —
366 CI27925 Direct Blue 67 003354970
367 CI28160 Direct Red 81 002610119 — — —
368 CI28210 Direct Red 153
369 CI28215 Direct Red 127 — — —
370 CI28230 Direct Red 117 — —
371 CI28240 Direct Black 127
372 CI28255 Direct 006104569 — — —
Orange 74
460
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
Water: inorganic — 58.2/1973 — —
salts
Ditto — — — —
Ditto — 530/1973
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — 23.6/1973
Ditto — 119/1973
Ditto — 41.4/1973
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — 68.2/1973
Ditto — 5.5/1973
Ditto — — — —
Ditto — 337/1973 — —
Ditto — — —
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — — —
(Continued)
461
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD50' m9/k9 Toxicology TLV Carcinogen
373 CI28280 Direct Green 38 — — — — —
374 CI28360 Direct Red 152
375 CI29000 Direct
Yellow 44
376 CI29005 Direct
Yellow 41
377 CI29025 Direct 003214479
Yellow 50
378 CI29060 Direct 006420333 —
Yellow 34
379 CI20965 Direct Red 79 001937344
380 CI29090 Direct
Orange 83
381 C129100 Direct Red 31 005001729 —
382 CI29105 Direct Violet 14
383 CI29110 Direct Red 149
384 CI29120 Direct Violet 66
385 CI29125 Direct Violet 48
386 CI29150 Direct 003626366
Orange 26
387 CI29155 Direct 006420402 —
Orange 29
388 CI29156 Direct
Orange 102
389 CI29160 Direct Red 23 003441143
390 CI29165DirectRed4 006420413
462
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
Water: inorganic — — — —
salts
Ditto — — — —
Ditto — 459/1973
Ditto — — — —
Ditto — 113/1973
Ditto — — — —
Ditto — 40.9/1973
Ditto — — — —
Ditto — 20.0/1973
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — 43.2/1973
Ditto — 117/1973
Ditto — 115/1973
Ditto — — — —
(Continued)
463
-------
TABLE B-3. (Continued)
Compound Chem. Abttr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDg(j, mg/kg Toxicology TLV Carcinogen
391 CI29166 Direct — — —
Brown 112
392 CI29175 Direct Red 62
393 CI29180 Direct Red 73 — — — —
394 CI29185 Direct Red 24 006420446
395 CI29190 Direct Red 26 003687807
396 CI29200 Direct Red 72
397 CI29210 Direct Red 122 006420468
398 CI29225 Direct Red 83 015418163 — — — —
399 CI20015 Direct — —
Black 78
400 CI30045 Direct Brown 1 003811710 — — —
401 CI30120 Direct 006360549
Brown 154
402 CI30140 Direct Brown 6 002893803 — — —
403 CI30145 Direct 016071866 —
Brown 95
404 CI30220 Direct Green 39 — — — —
405 CI30235 Direct Black 38 001937377 — — —
406 CI30245 Direct Black 4 002429836 — — ' — —
407 CI30280 Direct Green 1 003626286 — — — —
408 CI30295 Direct Green 6 004335095 —
409 CI30315 Direct Green 8 005422173 — — —
410 CI31560 Direct Black 9 — — — —
464
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
Water: inorganic — — — —
salts
i Ditto — — — —
Ditto — — — —
Ditto — 182/1973
Ditto — 98.6/1973
Ditto — 165/1973
Ditto — — — —
Ditto — 74.6/1973 —
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — 258/1973
Ditto — — — —
Ditto — 3.065/1973
Ditto — 75.0/1973
Ditto — 85.9/1973
Ditto — — —
Ditto — — — —
Ditto — — — —
(Continued)
465
-------
TABLEB-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgg, mg/kg Toxicology TLV Carcinogen
411 CI31565 Direct Black 9
412 CI31575 Direct Black 2
413 CI31600 Direct Black 80 008003698
414 CI31665 Direct Black 36
415 CI31930 Direct Blue 26
416 CI34010 Direct Blue 126 008006051
417 CI34015 Direct Brown 32
418 CI34045 Direct Green 26 006388267
419 CI34085 Direct Blue 120 003626402
420 CI34090 Direct Blue 003626300
120A
421 C134140 Direct Blue 71 004399557
422 CI34146 Direct Blue 74 033540942
423 CI34215 Direct Black 56
424 CI34200 Direct Blue 78 002503733
425 CI34215 Direct Blue 81 006252579
426 CI34220 Direct Blue 75
427 CI34260 Direct Green 51 — —
428 CI35005 Direct Brown 44 006252626
429 C135255 Direct Black 19 006428315
430 CI35435 Direct Black 22
431 CI35660 Direct Brown 31 002429814
466
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
Water: inorganic salts — — — —
Ditto — — — —
Ditto — 313/1973
Ditto — — — —
Ditto — — — —
Ditto — 42.3/1973
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — — — —
Ditto — 59.6/1973
Ditto — — — —
Ditto — — — —
Ditto — 47.7/1973
Ditto — — • — —
Ditto — — —
Ditto — — — —
Ditto — — —
Ditto — — — —
Ditto — — — —
Ditto — 39.6/1973
(Continued)
467
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
432 CI35760 Direct Red 84
433 CI35780 Direct Red 80 002610108
434 CI35790 Direct Red 32 033448689
435 CI35870 Direct Black 75 002679494
436 CI36200 Direct
Brown 106
437 CI36300 Direct
Brown 74
438 CI3700 Base Azoic
Diazoic44
439 CI3700Salt Axoic
Diazoic 44
440 CI37005 Salt Azoic
Diazoic 2
441 CI37005 Base Azoic
Diazoic 2
442 CI37010 Base Azoic
Diazoic 3
443 CI37010 Salt Azoic
Diazoic 3
444 CI37010 Azoic Brown 3
445 CI37010 Azoic Orange 3 —
446 CI37025 Salt Azoic
Diazoic 6
000088744 535 rat
(ZR BNW)
447 CI37035 Salt Azoic
Diazoic 37
000100016 3249 rat
(ZR DNW)
LDLo:40 mg/kg
ivn-man
USDS air: TWA
1 ppm
468
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Diazotization
Coupling
4 Water: inorganic salts
Ditto
Ditto
297/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
153/1973
Ditto
Ditto
Ditto
Ditto
37.3/1973
Ditto
Ditto
2)330, 111
Ditto
Ditto
2)330, 111
(Continued)
469
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
448 CI37040 Salt Azoic
Diazoic 9
000089634
(ZR DG
BNWZR DG
BNW)
LD50:63 mg/kg,
ivn-mus
449 CI37050 Azoic
Orange 10
000121506
(ZR BG
EXFFF)
LDLo: 100 mg/kg,
ipr-mus
450 CI37050 Salt Azoic
Diazoic 49
451 CI37080 Base Azoic
Diazoic 46
452 CI37085 Base Azoic
Diazoic 11
003165933
(ZR DG B
&GH)
LD50:560 mg/kg,
ipr-rat
453 CI37085 Salt Azoic
Diazoic 11
003165933*
454 CI37090 Salt Azoic
Diazoic 32
455 CI37090 Base Azoic
Diazoic 32
456 CI37090 Azoic Red 1
457 CI37090 Azoic
Yellow 3
458 CI37090 Azoic Red 6
459 CI37090 Azoic
Yellow 1
460 CI37100 Azoic Red 16
461 CI37100 Base Azoic
Diazoic 34
462 C137100 Base Azoic
Diazoic 34
470
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year
Uses
References
Diazotization
Coupling
4 Water: inorganic talts
97.3/1973
2)330, 106
Ditto
4 Ditto
2)330, 1143
Ditto
4 Ditto
26.8/1973
Ditto
4 Ditto
Ditto
4 Ditto
2)330,1143
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
137/1973
Ditto
Ditto
Ditto
Ditto
77.3/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
(Continued)
471
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
463 CI37105 Salt Azoic
Oiazoic 12
464 C137105 Base Azoic
Diazoic 12
465 CI37107 Azoic
Coupling 107
466 CI37110 Base Acoid
Diazoic 8
467 CI37110 Salt Azoic
Diazoic 8
468 CI37120 Salt Azoic
Diazoic 10
469 CI37120 Base Azoic
Diazoic 10
470 CI37120 Azoic
Brown 10
471 CI37120AzoicRed2
472 C137120 Azoic
Brown 7
473 CI37120 Azoic
Yellow 2
474 CI37125 Base Azoic
Diazoic 5
475 CI37125 Salt Azoic
Diazoic 5
476 CI37130 Base Azoic
Diazoic 13
477 CI37130 Salt Azoic
Diazoic 13
478 CI37135 Salt Azoic
Diazoic 1
472
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10J kg/year
Uses
References
Diazotization 4 Water: inorganic salts
Coupling
164/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
45.0/1973
Ditto
Ditto
15.5/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
— 9.1/1973
Ditto
Ditto
Ditto
Ditto
153/1973
Ditto
Ditto
1
Ditto
Ditto
166/1973
Ditto
Ditto
108/1973
473
(Continued)
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abttr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
479 CI37150 Azoic Red 12
480 CI37150 Salt Azoic
Diazoic 42
481 CI37151 Salt Azoic
Diazoic 14
482 CI37151 Salt Azoic
Diazoic 28
483 CI37151 Base Azoic
Diazoic 14
484 CI37151 Base Azoic
Diazoic 28
485 CI37155 Azoic
Diazoic 24
486 CI37155 Azoic Blue 7
487 CI37165 Azoic Violet 1
488 CI37165 Salt Azoic
Diazoic 41
489 CI37175 Salt Azoic
Diazoic 20
490 CI37175 Azoic Blue 6
491 CI37175 Azoic Green 1
492 CI37185 Azoic
Diazoic 0
006232571*
493 CI37185 Disperse
Black 2
006232571
494 CI37210 Base Azoic
Diazoic 4
474
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Diazotization
Coupling
4 Water: inorganic salts
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
4
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
(Continued)
475
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
495 C137235 Base Azoic
Diazoic 48
00119904* 1920 rat
(WLN 1OR
BZ E-2)
TDLo:13gm/kg/
52WITFX:NEO
orl-rat
496 CI37235 Salt Azoic
Diazoic 48
Ditto
Ditto
497 CI37235 Disperse
Black 6
Ditto
— Ditto
498 CI37255 Salt Azoic
Diazoic 35
499 CI37275 Salt Azoic
Diazoic 36
500 CI37505 Azoic
Coupling 2
501 CI37505 Azoic Blue 7
502 C137505 Azoic Blue 6
503 CI37505 Azoic Violet 1
504 CI37505 Azoic
Orange 10
505 CI37510 Azoic
Coupling 10
506 C137515 Azoic
Coupling 17
507 CI37520 Azoic
Coupling 18
508 CI37520 Azoic Red 16
509 CI37520 Azoic Red 6
510 CI37525 Azoic
Coupling 8
511 CI37526 Azoic
Coupling 21
476
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Diazotization
Coupling
4 Water: inorganic salts
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
77.3/1973
Ditto
Ditto
Ditto
Ditto
43.2/1973
477
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abitr.
Registry No. Oral Toxicity,
(WLN) LO50, mg/kg
Toxicology
TLV
Carcinogen
512 CI37527 Azoic
Coupling 29
513 CI37530 Azoic
Coupling 20
514 CI37530 Azoic Red 2
515 CI37531 Azoic
Coupling 34
516 CI37535 Azoic
Coupling 11
517 C137540 Azoic
Coupling 24
518 CI37545 Azoic
Coupling 19
519 CI37550 Azoic
Coupling 12
520 CI37550 Azoic Red 12
521 CI37550 Azoic Brown 10
522 CI37558 Azoic Red 1
523 CI37558 Azoic Orange 3
524 CI37558 Azoic Yellow 3
525 CI37558 Azoic
Coupling 14
526 CI37560 Azoic
Coupling 4
527 CI37565 Azoic
Coupling 7
528 CI37575 Azoic
Coupling 3
478
-------
Proceu Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic salts
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
9.1/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
4
4
4
4
4
4
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
137/1973
37.3/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
(Continued)
479
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD50,mg/kg
Toxicology
TLV
Carcinogen
529 CI37585 Azoic
Coupling 36
530 C137585 Azo ic G reen 1
531 CI37595 Azoic
Coupling 13
532 CI37600 Azoic
Coupling 15
533 CI37600 Acoid Brown 3
534 CI37600 Azoic Brown 7
535 CI37605 Azoic
Coupling 16
536 CI37610 Azoic
Coupling 5
537 CI37610 Azoic
Yellow 3
538 CI37610 Azoic
Yellow 2
539 CI37610 Azoic
Yellow 1
540 CI37615Azoic
Coupling 35
541 CI40000 Direct
Yellow 11
001325377
542 CI40001 Direct
Yellow 6
001325388
543 CI40002 Direct
Orange 15
544 CI40003 Direct
Orange 15
480
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic salts
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
9.1/1973
Ditto
Ditto
Ditto
Ditto
Condensation 5
Precipitation
Filtration
Condensation Pre- 5
cipitation Reduc-
tion Filtration
Water: brines con-
taining small amounts
of organic materials
1.220/1973
265/1973
Ditto
Ditto
Ditto
Condensation
Precipitation
Filtration
Ditto
57.3/1973
(Continued)
481
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDSO, mg/kg
Toxicology
TLV
Carcinogen
545 CI40045 Direct
Yellow 21
546 CI40210 Direct
Orange 61
547 CI40215 Direct
Orange 39
001325548
548 CI40215 Direct
Orange 34
001325548
549 CI40220 Direct
Orange 34
550 CI40260 Direct
Orange 37
551 CI40265 Direct
Orange 37
552 CI40290 Direct Red 111
553 CI40300 Direct
Yellow 106
554 CI40600 Fluorescent
Brightener 30
002606931
555 CI40621 Fluorescent
Brightener 9
000133664
556 CI40622 Fluorescent
Brightener 28
004404437
557 CI40630 Fluorescent
Brightener 1
015339396
558 CI40645 Fluorescent
Brightener 46
006416688
482
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Condensation
Precipitation
Filtration
Water: brines con-
taining small amounts
of organic materials
57.3/1973
Ditto
Ditto
57.3/1973
Ditto
46.8/1973
Ditto
Ditto
Ditto
11.8/1973
Condensation
Precipitation
Filtration
Water: brines con-
taining small amounts
of organic materials
Ditto
Ditto
Condensation
Reduction
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
336/1973
Ditto
Ditto
523/1973
Condensation
Oxidation
Filtration
Ditto
(Continued)
483
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
559 CI41000 Basic
Yellow 2
002465272 150 cat
(1N1&R
D2YUM&GH)
TDLo:40gm/kg/
87WC,TFX:CAR
orl-rat
560 CI41000 Solvent
Yellow 34
000492808
TDLo:29gm/kg/
52WC,TFX:CAR
orl-mus
561 CI41001 Basic Yellow 37 006358367
562 CI42000 Basic Green 4 000569642 LDLo:75
(L6YDYJ
AUYR&R
DN1&1&DUK
&G &25/2S)
563 CI42000PTA Pigment 000569642*
Green 4
564 CI42000 PMA Pigment Ditto
Green 4
565 CI42000 Solvent
Green 1
Ditto
566 CI42025 Pigment Basic 003521060*
Blue 2
567 CI42025 PTA Pigment 003521060"
Blue 9
568 CI42025 PMA Pigment Ditto
Blue 9
569 CI42025 Basic Blue 2 Ditto
570 CI42025 Basic Blue 1 003521060
484
-------
Process
(Sources Process
of Compound) No.
Condensation 6,18
Filtration
Precipitation
Waste
Associated Wastes Treatment
Water: brines con- —
laminated with small
amounts of organic
materials, residual
amounts of metal ions
and lead sulfate
Total
Production
103 kg/year
Uses References
2)330,110
Ditto
Ditto
Ditto
Condensation
Oxidation
Crystallization
Filtration
Water: brines con-
taminated with small
amounts of organic
materials. Also, lead
sulfate is precipitated
as a solid waste
312/1973
2)330, 77
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Condensation 6,18 Water: brines con-
Oxidation taminated with small
Crystallization amounts of organic
Precipitation materials, residual
Filtration amounts of metal ions
and lead sulfate
Ditto
Ditto Ditto
Ditto
Ditto Ditto
Ditto
Ditto Ditto
Ditto
Ditto Ditto
(Continued)
485
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
571 CI42040 Basic Green 1 000633034
(L6YDYJ
AUYR&R
DN2&2& DUK
2&2 &WSQ O
&2B/34
LDLo:25
mg/kg mus
572 CI42040 PTA Pigment
Green 1
000633034*
573 CI42040 PMA Pigment Ditto
Green 1
574 CI42040 PTA Pigment Ditto
Green 2
575 CI42040 PMA Pigment Ditto
Green 2
576 CI42045 Acid Blue 1 000129179
LD50:1200 mg/kg
ivn-mus
LDLo: 6500 mg/kg/
33WI,TFX:NEO
scu-rat
577 CI42053 FD&C
Green 3
002353459
(WSO&R DIN2&R
D-2V*R DQ
BSWO &-NA- 2)
TDLo:5925 mg/kg/
48WITFX:CAR,
scu-rat
578 CI42080 Acid Blue 7
003486304
579 CI42085 Acid Green 3 004680788
(WSO&R D1N2&R
D2Y*R &-NA-)
TDLo:600 mg/kg/
43WC,TFX:CAR
orl-rat
580 CI42090 Acid Blue 9
002650182
(L6YDYJAUYR
BSWOR DN2&1R
CSWQ&& DUK2&1R
CSWQ &ZH &ZH
&37/17)
LD50:4600 mg/kg,
scu-mus
TDLo:17gm/kg/
2YI,TFX:CAR
scu-rat
581 CI42090 Lake Pigment
Blue 24
002650182*
Ditto
— Ditto
486
-------
Process
(Sources
of Compound)
Condensation
Crystallization
Oxidation
Precipitation
Filtration
Process
No. Associated Wastes
6,8 See above item
Total
Waste Production
Treatment 103 kg/year
38.2/1973
Uses References
2)75, 330
Ditto
Ditto Ditto
Ditto
Ditto
Ditto Ditto
2.7/1973
Ditto
Ditto Ditto
Ditto
Ditto Ditto
30.5/1973
Ditto
Ditto Ditto
2)330, 421
Condensation
Crystallization
Precipitation
Oxidation
Filtration
Sulfonation
Water: brines con-
taminated with small
amounts of organic
materials, and lead
sulfate is precipitated
as a solid waste
Condensation
Crystallization
Oxidation
Filtration
Ditto
Ditto
Ditto
93.6/1973
2)330,80
Ditto
6,18
Ditto
971/1973
Ditto
Ditto
Ditto
Ditto
(Continued)
487
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
582 C142090 FD&C Blue 1 002650182
See above item
— See above item
583 CI42095 Acid Green 5 005141208
(WSO&R D1N2&R
D-2Y*R DSWO
&-NA- 2)
TDLo:1290gm/kg/
86WC,TFX:CAR
orl-rat
584 CI42100 Acid Green 9 004857812
585 CI42140Basic BlueB
003943826
586 CI42170 Acid Green 22 005863514
587 CI45170 PTA Pigment 001326030*
Violet 1
588 CI42500 Basic Red 9
000548618
589 CI42510 Basic Violet 14 000632995 —
590 CI42510PMA Pigment 000632995*
Violet 9
591 CI42510 Solvent Red 41 003248939
488
-------
Process
(Source* Process
of Compound) No.
Total
Waste Production
Associated Wastes Treatment 10^ kg/year
Uses
References
See above item
See above item
83.2/1973
2)330, 80
Condensation
Precipitation
Oxidation
Filtration
Sulfonation
Ditto
Ditto
Condensation
Crystallization
Oxidation
Filtration
Ditto
Condensation 6,18 Water: brines con-
Crystallization taminated with small
Oxidation amounts of organic
Filtration materials residual
Precipitation amounts of metal
ions and lead sulfate
7.3/1973
Condensation
Crystallization
Oxidation
Filtration
Water: brines con-
taminated with small
amounts of organic
materials and lead
sulfate is precipitated
as a solid waste
Precipitation
Filtration
Condensation
11,18 Ditto
52.3/1973
Oxidation
Filtration
Air: possibly signifi-
cant and hazardous
amounts of toxic
arylamines
Water: brines con-
taminated with vary-
ing amounts of
organic substances
Solids: sludges con-
taining large amounts
of metal ions
Ditto 7 Ditto
Ditto 7 Ditto
Ditto
Ditto
(Continued)
489
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abttr.
Registry No. Oral Toxicity,
(WLN)
LD50.mg/kg
Toxicology
TLV
Carcinogen
592 CI42520 Basic Violet 2 003248917
593 CI42535 Basic Violet 1 008004873
594 CI42535 PTA Pigment 008004873*
Violet 3
595 CI42535 PMA Pigment Ditto
Violet 3
596 CI42535 Solvent
Violet 8
Ditto
597 CI42536 Basic Violet 13
598 C142555 Basic Violet 3 000548629 1000 rat LDLo:15 mg/kg
(1N1&R D- ipr-rat
3Y* &G)
599 CI42555 Solvent
Violet 9
00054629* 1000 rat
Ditto
600 C142561 Acid Blue 34 006460055
601 CI42595 Basic Blue 7 002390605
602 CI42595 Solvent Blue 5 001325866
490
-------
Process
(Sources Process
of Compound) No.
Waste
Associated Wastes Treatment
Total
Production
10^ kg/year
Uses
References
Oxidation 7
Filtration
See item above
Oxidation
Filtration
Benzylation
Ditto
555/1973
Ditto
Ditto
18.2/1973
Ditto
Ditto
191/1973
Ditto
Ditto
Ditto
Ditto
Condensation 8,18 Air: small amounts
Filtration of phosgene
Precipitation Water: lead sulfate
precipitate and
brine which contains
lead and small amounts
of organic materials
and residual amounts
of metal ions
2)330, 73
Ditto
Ditto
Ditto
Ditto
Condensation
Filtration
Sulfonation
Air: See 598
Water: lead sulfate
precipitate and
brine which contains
lead and small
amounts of organic
materials
Condensation
Crystallization
Oxidation
Filtration
Precipitation
6,8 Water: brines con-
taminated with small
amounts of organic
materials, residual
amounts of metal
ions & lead surf ate
78.2/1973
Ditto
Ditto
Ditto
(Continued)
491
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
603 CI42595 PTA Pigment 001325877*
Blue 1
604 CI42595 PMA Pigment 001325877*
Blue 1
605 CI42600 PTA Pigment 002390592*
Blue 14
606 CI42600 PMA Pigment 002390592*
Blue 14
607 CI42600 Basic Violet 4 002390592
608 CI42640 Acid Violet 49 001694093 —
TDLo:9400 mg/kg/
2YI,TFX:NEO
scu-rat
609 CI42640 FD&C Violet 1 001694093
— Ditto
610 CI42645 Acid Blue 15 005863467
611 CI42650 Acid Violet 17 004129844
612 CI42655 Acid Blue 90 006104581
613 CI42660 Acid Blue 83 006104592
614 CI42735 Acid Blue 104 006505302
615 CI42735 Lake Acid
Blue 104
006505302* —
616 CI42750 Pigment
Blue 19
492
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
See item above
6,18
See item above
Ditto
Ditto Ditto
45.9/1973
Condensation
Filtration
Precipitation
8,18
See Item 598
Ditto
8,18
Ditto
Ditto
Precipitation
Filtration
8,18 Ditto
18 Water: brines may
also contain resi-
dual amounts of
metal ions
26.4/1973
2)330, 77
Ditto
18
Ditto
Ditto
See Item 608
18
See Item 608
13.2/1973
Condensation
Oxidation
Precipitation
Filtration
Sulfonation
Water: brines con-
taminated with small
amounts of organic
materials and lead
sulfate is precipitated
as a solid waste
Precipitation 18 Water: brines may
Filtration also contain residual
amounts of metal
ions
(Continued)
493
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgo, mg/kg Toxicology TLV * Carcinogen
617 CI42760 Solvent 002152649
Blue 23
618 CI42775 Solvent Blue 3
619 CI42780 Acid Blue 93 028983564
620 CI43820 Mordant Blue 3 003564189
621 CI43830 Mordant Blue 1 001796925
622 CI44025 Acid Green 16 001325446
623 CI44040 Basic Blue 11 002185866
624 CI44040 Solvent Blue 6 006786841
625 CI44040 PTA Pigment 002185866*
Blue 10
626 CI44040 PMA Pigment 002185866*
Blue 10
627 CI44045 PTA Pigment 002580565*
Blue 2
628 CI44045 PMA Pigment Ditto —
Blue 2
629 CI44045 Solvent Blue 4 006786830
630 CI44045 Basic Blue 26 002580565 —
494
-------
Process
(Sources Process
of Compound) No.
Condensation 7
Filtration
Oxidation
Ditto 7
Condensation 9
Oxidation
Filtration
Ditto 9
Condensation 8
Oxidation
Condensation 10,18
Oxidation
Nitrosation
Hydrolysis
Precipitation
Filtration
Total
Waste Production
Associated Wastes Treatment 10^ kg/year Uses References
See Item 588 — — — —
Ditto — — — —
Air: noxious gas — — — —
emissions from use
of nitrogen oxides
Water: brines con-
taining small amounts
of organic materials
Ditto — — — —
See Item 600 — 37.7/1973
Air: nitrogen oxides — — — —
and formaldehyde
Water: brines con-
taining heavy metal
ions
Solids: distillation
residues and preci-
pitated lead surfate
Ditto
Ditto Ditto
Ditto
Ditto Ditto
Ditto
Ditto Ditto
Ditto
Ditto Ditto
Ditto
Ditto Ditto
Ditto
Ditto Ditto
Ditto
Ditto Ditto
13.2/1973
(Continued)
495
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
631 CI44090 Acid Green 50 003087169 2000 rat
TDLo:270gm/kg/
30WITFX:CAR,
scu-rat
632 C145100 Acid Red 52 003520421
633 C145160 Basic Red 1
000989388
634 C145160 PTA Pigment 00989388*
Red 81
635 CI45160 PMA Pigment Ditto
Red 81
636 CI45170 PMA Pigment 001326030*
Violet 1
637 C145170 Sol vent Red 49 000509342
638 CI45170 Solvent Red 35 000081889
639 CI45170FD&C Red 37 000509342
640 C145170 FD&C Red 19 000081889
641 CI45170 Basic Violet 10 000081889 —
642 C145175 Basic Violet 11 002390638
643 C145180 Mordant Red 27 006359224 —
496
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10"* kg/year
Uses
References
Condensation
Oxidation
8
See Item 600
2)22, Splmnt
Condensation
Cyclization
Oxidation
11 Water: brines con-
taminated with small
amounts of organic
chemicals
Solid: sludge of iron
oxide
42.7/1973
294/1973
Precipitation 11,18 Water: brines con-
Filtration laminated with small
Condensation amounts of organic
chemicals and resi-
dual amounts of
metal ions
Solid: See Item 632
Ditto
Ditto Ditto
Ditto
Ditto
Ditto
Ditto
Precipitation
Filtration
Condensation
Ester ificat ion
Ditto Ditto
Ditto Ditto
Ditto Ditto
Ditto Ditto
Ditto Ditto
143/1973
Condensation
11 Water: brines con-
taminated with small
amounts of organic
chemicals
Solid: sludge of
iron oxide
(Continued)
497
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abttr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
644 CI45350 D&C Yellow 7 000518456 LDLo:2500
(TC666BO
EVJ TR BVQ&
MQ)
645 CI45350 D&C Yellow 8 000518478
(T C666 BO
EVJ TR BO&
MO &-NA- 2)
LD50:1700 mg/kg,
ipr-rat
646 CI45350 Acid Yellow 73 Ditto
Ditto
647 CI45370 D&C Orange 5 000596032*
648 CI45380 D&C Red 22 000548265
(T C666 BO
EVJDEFEIR
BVO& LE MO
NE&-NA-2)
LDLo:500 mg/kg,
ipr-rat
TDLo: 7200 mg/kg/
44WI,TFX:NEO
scu-rat
649 CI45380 Acid Red 87 Ditto
Ditto
— Ditto
650 CI45380 Pigment Red 90 015086949*
651 CI45380D&CRed21 015086949 —
652 CI45410D&CRed27 001847287*
653 CI45410D&C Red 28 001847287
654 CI45425 D&C Orange 10 033239199*
655 CI45430 D&C Red 3
000568638 1895 rat
(T C666 BO
EVJDI Fl IR
BVO& LI MO
NI&-NA-2)
LDLo: 200 mg/kg
ivn-rat
498
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
See item above
11
See item above
2)330, 557
Ditto
11
Ditto
Ditto
Ditto
11
Ditto
Ditto
Precipitation 12,18 Water: hydrogen
Filtration halide and small
Halogenation amounts of highly
colored products &
residual amounts of
metal ions
Ditto
Ditto
Ditto
2)330, 557
Ditto
Ditto Ditto
Ditto
Ditto Ditto
720/1973
Ditto Ditto Ditto
Ditto Ditto Ditto
Ditto Ditto Ditto
Ditto Ditto Ditto
Ditto Ditto Ditto
— — — —
—
—
—
155/1973 — 2)330,558
(Continued)
499
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgo, mg/kg Toxicology TLV Carcinogen
656 CI46005 Basic Orange 14 000065612
657 CI46500 Pigment Violet 001047161
19
658 CI4700D&C Yellow 11 008003223
659 CI47000 Solvent 008003223
Yellow 33
660- CI47005D&C Yellow 10 008004920
661 CI47005 Acid Yellow 3 008004920
662 CI47020 Disperse 012223857
Yellow 54
663 C147023 Disperse 012223868 —
Yellow 64
664 CI47035 Direct
Yellow 5
665 C14800 Disperse 004361846
Yellow 31
666 CI48013 Basic Violet 16
500
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Oxidation
Condensation
Nitration
Reduction
Cyclization
10
See Item 623
Cyclization 13 Water: brines con-
Halogenation taining small amounts
Amination of organic chemicals
Solid: acidic wastes
Condensation 14 Water: possibly brines
contaminated with
small amounts of
organic materials
Ditto
14
Ditto
Condensation 14,15, Water: dilute sulfuric
Sulfonation 18 acid and brine solu-
Precipitation tions contaminated
Filtration with small amounts
of organic chemicals
and residual amounts
of metal ions
Ditto
Ditto
Ditto
Condensation 14,15
Sulfonation
Ditto
606/1973
Condensation
14
See Item 658
Condensation 14,15 Water: dilute sul-
Sulfonation furic acid and brine
solutions contaminated
with small amounts of
organic chemicals
65.5/1973
Condensation
Filtration
See Item 620
Condensation
16 Water: acidic brines
containing small
amounts of organic
chemicals
216/1973
501
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q' m9^9 Toxicology TLV Carcinogen
667 CI48015BasicRed 13 003648360
668 CI48020 Basic Violet 7 006441823 — — — —
669 CI48035 Basic Orange 21 003056937 — — —
670 CI48040 Basic Orange 22 004657005 —
671 CI48055 Basic Yellow 11 004208804 — — — —
672 CI48070 Basic Red 12 006320145 — —
673 CI48100 Basic Yellow 23
674 CI49000 Direct 008064606 — — — —
Yellow 59
675 C149005 Basic Yellow 1 002390547
676 CI49005 PMA Pigment 002390547
Green 2
677 CI49005 PTA Pigment 002390547
Green 2
678 CI49010 Direct 015724693
Yellow 7
502
-------
Process
(Sources Process
of Compound) No.
Waste
Associated Wastes Treatment
Total
Production
103 kg/year
Uses
References
Condensation
16
See above item
13.6/1973
Ditto
16
Ditto
Ditto
16
Ditto
427/1973
Ditto
16
Ditto
Ditto
16
Ditto
755/1973
Ditto
16
Ditto
Ditto
16
Ditto
Methylation
Sulfonation
Dehydrogenation
17 Air: possibly
hydrogen sulfide
Water: dilute sul-
furic acid and
ammoniacal brine
contaminated with
small amounts of
organic material
Methylation
Sulfonation
Dehydrogenation
Precipitation
Filtration
17,18 Air: see above
Water: dilute sul-
furic acid and
ammoniacal brine
contaminated with
small amounts of
organic materials
and residual amounts
of metal ions
Ditto
Ditto
Ditto
28.6/1973
Ditto
Ditto
Ditto
See Item 674 17
See Item 674
(Continued)
503
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
679 C150204 Basic 0
680 CI50240 Basic Red 2 000477736
681 CI50400 Solvent Blue 7 008004986
682 CI50405 Acid Blue 20
683 CI50415 Solvent Black 5 012227804*
684 C150415 Solvent Black? 012227804
685 CI50420 Acid Black 2 012227815 —
686 CI51004 Basic Blue 4 002787919
687 CI51004 Basic Blue 3 002787919
688 C151175 Basic B lue 6 000966621
689 CI51300 Direct Blue 106 006527704 —
690 CI51319 Pigment
Violet 23
006358301 —
691 CI51320 Direct Blue 108 001324589
504
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Waste
Treatment
Total
Production
10^ kg/year
Uses
References
Condensation 19 Water: effluent would
contain chloride, iron,
& chromium ions, as
well as small amounts
of organic materials
Oxidation
Precipitation
Fractional
19
Ditto
Condensation
19
Ditto
Sulfonation 15,18
Condensation
Water: dilute sulfuric
acid and brine solu-
tions contaminated
with small amounts
of organic chemicals
& residual amounts
of metal ions
Condensation
Ditto
19
19
See Item 679
Ditto
Sulfonation 15 Water: dilute sulfuric
acid and brine solu-
tions contaminated
with small amounts
of organic chemicals
Nitrosation 20 Water: brines con-
Condensation taining small amounts
of organic materials
Ditto
Ditto
Concensation
Sulfonation
Condensation
Cyclization
20
20
20
20
Ditto
Ditto
Ditto
Ditto
341/1973
— 127/1973
Sulfonation
15
See Item 685
(Continued)
505
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abttr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
692 C152015 Basic Blue 9
000061734
(T C666 BN
ISJ FN1&1
LNI&1 &G
& 12/28
LDLo: 100 mg/kg
ivn-mus
LD50:82 mg/kg
ivn-mus
693 CI5300 Leuco Sulfur
Brown 1
694 CI53001 Solubilized
Sulfur Brown 1
695 CI53010 Leuco Sulfur
Yellow 9
696 CI53040 Leuco Sulfur
Yellow 1
697 CI53050 Sulfur Orange 1
698 CI53055 Sulfur Brown 10 —
699 CI53055 Leuco Sulfur —
Brown 10
700 CI53056 Solubilized Sulfur
Brown 10
701 CI53090 Leuco Sulfur
Brown 26
702 CI53090 Sulfur Brown 26
703 CI53120 Leuco Sulfur
Yellow 2
704 CI53160 Sulfur
Yellow 4
705 CI53160 Leuco Sulfur
Yellow 4
706 CI53185 Leuco Sulfur
Black 1
506
-------
Procett Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Oxidation
Cyclization
Precipitation
Filtration
21 Water: brine containing
Mn, An, Al, & Cr ions
2)330, 872
Baking
Filtration
22 Water: brines containing
inorganic sulfur com-
pounds & small amounts
of organic chemicals
Ditto
22
Ditto
See Item 693 22 See Item 693
Ditto
22 Ditto
Ditto
22 Ditto
Ditto
22 Ditto
See Item 693 22 See Item 693
Ditto
Ditto
22
22
Ditto
Ditto
Ditto
22
Ditto
Ditto
22
Ditto
Ditto
22 Ditto
(Continued)
507
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
707 CI53185 Sulfur Black 1 —
708 CI53186 Solubilized Sulfur
Black 1
709 CI53190 Leuco Sulfur
Black 10
710 CI53195 Sulfur Black 2
711 CI53195 Leuco Sulfur
Black 2
712 CI53196 Solubilized Sulfur
Black 2
713 CI53205 Sulfur Black 5
714 CI53228 Leuco Sulfur
Red 10
715 CI53235 Sulfur Blue 5
716 CI53235 Leuco Sulfur
Blue 1
717 CI53246 Leuco Sulfur
Brown 14
718 CI53246 Sulfur —
Brown 14
719 CI53290 Leuco Sulfur —
Black 11
720 CI53320 Sulfur Brown 52 —
721 CI53325 Sulfur Brown 60 —
722 CI53440 Sulfur Blue 7 001327577 —
723 C153440 Leuco Sulfur 001327577 —
Blue?
508
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment icP kg/year
Uses
References
See above item 22 See above item
Condensation 22 See Item 693
Ditto
22 Ditto
Ditto
22 Ditto
Ditto
22 Ditto
Condensation 22 See Item 693
Ditto
22 Ditto
Ditto
22 Ditto
Ditto
22 Ditto
Ditto
22 Ditto
Ditto
22 Ditto
Baking
Filtration
22 Ditto
Ditto
22
22
22
Ditto
Ditto
Ditto
(Continued)
509
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abttr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
724 CI53441 Solubilized
Sulfur Blue?
725 CI53450 Leuco Sulfur 012262269
Blue 13
726 CI53570 Leuco Sulfur
Green 3
727 CI53571 Leuco Sulfur
Green 2
728 CI53571 Sulfur Green 2
729 CI53630 Vat Blue 43
730 CI53680 Leuco Sulfur
Brown 20
731 CI53720 Sulfur Red 6
732 CI53721 Sulfur Brown 12 — —
733 CI53830 Leuco Sulfur
Red 5
734 CI53830 Sulfur Red 5 — —
735 CI5800 Mordant Red 11 000072480 —
736 C158000 Lake Pigment 000072480*
Red 83
737 CI58005 Mordant Red 3 000130223 —
738 CI58055 PTA Pigment
Blue 7
739 CI58055 PMA Pigment
Blue?
510
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Condensation 22 Water: Brines contain-
ing inorganic sulfur
compounds and small
amounts of organic
chemicals
Ditto
22
Ditto
Ditto
22 Ditto
Ditto
22 Ditto
Ditto
Ditto
Baking
Filtration
22
22
22
Ditto
Ditto
Ditto
Condensation
22
Ditto
See Item 724
22
See Item 724
Ditto
Hydrolysis
Oxidation
22 Ditto
23 Water: brine contain-
ing sodium sulfite &
small amounts of
organic materials
Ditto
23
Ditto
30.9/1973
(Continued)
511
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abttr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
740 C159040 Ext. D&C
Green 1
006358696
741 CI59100 Vat Yellow 4 000128665
742 CI59101 Solubilized Vat 003564703
Yellow 4
743 C159105 Vat Orange 1 001324114
744 CI59106 Solubilized Vat 001324158
Orange 1
745 CI59300 Vat Orange 3 004378614
746 CI59300 Pigment Red 168 004378614
747 CI59700 Vat Orange 9 000128701
748 CI59705 Vat Orange 2 001324352
749 C159710 Vat Orange 4 001324330
750 C159800 Vat Blue 20 001324330
751 CI59815 Vat Blue 18 001324545
752 CI59825 Vat Green 1 000128585
512
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 103 kg/year
Uses
References
Hydrolysis 24 Water: effluent con-
taining sodium
sulfite
Benzylation
Cyclization
Condensation
Reduction
26 Water: brines with
excess alkali, man-
ganese ion, or alumi-
num ion and organic
substances
Solid: oxide sludge
44.6/1973
Sulfonation
15
See Item 658
Halogenation
12
Water: hydrogen
halide and small
amounts of highly
colored products
592/1973
Sulfonation
15
See Item 658
Halogenation
Ditto
12 See Item 743
12 Ditto
Dimertization
Cyclization
Purification
25 Water: brine con-
taining small
amounts of organic
chemicals
129/1973
Halogenation
Ditto
12 See Item 743
12 Ditto
Alkali Fusion
Condensation
Reduction
26 See Item 741
Halogenation
Reduction
Condensation
Alkali Fusion
Oxidation
Methylation
12 See Item 743
26 See Item 741
427/1973
944/1973
(Continued)
513
-------
TABLE B-3. (Continued
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
753 CI59826Solubilized Vat 002538843
Green 1
754 CI59850 Vat Green 9 006369659
755 CI6000 Vat Violet 10 000128643
756 CI60005 Vat Violet 9 001324170
757 CI60010 Vat Violet 1 001324556
758 CI60010 Pigment
Violet 31
001324556
759 CI60015 Vat Blue 26 004430551
760 CI60505 Solvent Red 111 000082382
761 CI60505 Disperse Red 9 000082382
762 CI60710 Disperse Red 15 000116858
763 CI60725 Disperse Blue 72
514
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
103 kg/year
Uses
References
Sulfonation 15 Water: dilute sulfuric
acid and brine solu-
tions contaminated
with small amounts of
organic chemicals
Condensation 26 Water: brines with
Reduction excess alkali, man-
Nitration ganese ion, or alumi-
Alkali Fusion num ion and organic
substances
Solid: oxide sludge
Chlorination 27 Water: dilute hydro-
chloric acid sodium
sulfide and manganous
sulfate
Halogenation
Ditto
Ditto
12 See Item 743
12 Ditto
12 Ditto
130/1973
Oxidation
Desulfurization
Methylation
Chlorination
Sulfide Formation
27 Water: dilute hydro-
chloric acid sodium
sulfide, manganous
sulfate, and brines
containing small
quantities of organic
compounds
Aminolysis
28 Water: brines con-
taining small amounts
of organic chemicals
Ditto
Oxidation
Aminolysis
28
23
Ditto
See Item 735
Sulfonation 15,23 Water: dilute sulfuric
Oxidation acid and brine solu-
Aminolysis tions contaminated
with small amounts
of organic chemicals
and sodium sulfite
(Continued)
515
-------
TABLt b-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WIN) LD5Q' m9/k9 Toxicology TLV Carcinogen
764 CI60725 Solvent 000081481 — — — —
Violet 13
765 CI60725 D&C Violet 2 000081481
766 CI60730 Acid Violet 43 004430186 — —
767 CI60755 Disperse Red 4 002379900 — —
768 CI60756 Disperse Red 60 017418585 — — — —
769 CI60767 Disperse Blue 27
770 CI61100 Disperse 000128950
Violet 1
771 CI61102 Disperse Violet
28
772 CI61105 Disperse 001220946
Violet 4
773 CI6115 Disperse Blue 9
774 CI61125 Acid Blue 23 033340339 —
775 CI61135 Acid Blue 127
776 CI61200 Reactive Blue 19 002580781 —
777 CI61200 Solvent Blue 12 — —
778 CI61205 Reactive Blue 5 016823511
779 CI61205 Reactive Blue 4 013324204
780 CI61211 Reactive Blue 2 012236827 —
781 CI61500 Disperse Blue 14 002475447
516
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
See above item 15,23 See above item
Ditto
Ditto Ditto
Methylation 29 See Item 760
Condensation 30 Water: brines con-
taining small amounts
of organic chemicals
& possibly small
amounts of heavy
metal ions
— 930/1973
Aminolysis
28 See Item 760
Oxidation
Aminolysis
Methylation
Oxidation
Aminolysis
Aminolysis
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Oxidation
Aminolysis
28 Ditto — 46.8/1973
29 See Item 760 — — —
28 Ditto — — — —
28 Ditto — — — —
28 Ditto — — — —
28 Ditto — — — —
28 Ditto — — — —
28 Ditto — — — —
28 Ditto — — — —
28 Ditto — — — —
28 Ditto — — — —
(Continued)
517
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5(V m9^k9 Toxicology TLV Carcinogen
782 CI61505 Disperse Blue 3 002475469
783 CI61525 Solvent Blue 11 000128858
784 CI61530 Acid Blue 27
785 CI61551 Solvent Blue 36 012226732
786 CI61552 Solvent Blue 59 — — —
787 CI61555 Solvent Blue 14 002646153
788 CI61565 Solvent Green 3 000128803
789 CI61565D8tCGreen6 000128803 — — —
790 CI61570D&CGreen5 004403901
791 CI61570 Acid Green 25 004403901 — — — —
792 CI61585 Acid Blue 80 004474242
793 C161705 Solvent Violet 14 — — —
794 CI61710 Acid Violet 34 006408635
795 CI61725 Vat Yellow 3
796 CI61800 Acid Violet 34
797 C162015 Disperse Red 11 002872482 —
798 CI62020 Acid Violet 41
799 CI62025 Disperse Violet 26
518
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Oxidation
Aminolysis
Aminolysis
Sulfonation
Aminolysis
Oxidation
Ditto
Ditto
Sulfonation
Oxidation
Aminolysis
Ditto
28
28
See above item
Ditto
15 See Item 753
28 See Item 743
28 Ditto
28 Ditto
15,28 See Item 753
Ditto Ditto
619/1973
67.7/1973
98.6/1973
153/1973
Sulfonation
Aminolysis
Aminolysis
Ditto
15,28 See Item 753
28 See Item 743
31 Ditto
Amide Formation 31 Ditto
Sulfonation
Aminolysis
Aminolysis
Condensation
Ditto
15,28 See Item 753
28 See Item 743
30 Water: brines con-
taining small amounts
of organic chemicals
and possibly small
amounts of heavy
metal ions
30 Ditto
(Continued)
519
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD50' m9/k9 Toxicology TLV Carcinogen
800 CI62030 Disperse 000082337
VioletS
801 CI62045 Acid Blue 62 004368563
802 CI62055 Acid Blue 25 006408782
803 CI62070 Acid Blue 145 006408806
804 C162073 Acid Blue 230
805 CI62080 Solvent Blue 13
806 CI62085 Acid Blue 47 004403898
807 CI62105 Acid Blue 78 006424755 —
808 CI62125 Acid Blue 40 006424857
809 CI62130 Acid Blue 41 002666173 —
810 CI62500 Disperse Blue 7 003179906 —
811 CI62560 Acid Green 41
812 CI6300 Acid Blue 43 002150609
813 CI63005 Solvent Blue 74
814 CI63010 Acid Blue 45 002861021 —
520
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment Id"* kg/year
Uses
References
Nitration
32 Air: nitrogen oxide
emissions
Water: spent acid
from nitration (e.g.,
sulfuric acid)
Aminolysis 28 Water: brines con-
taining small amounts
of organic chemicals
21.8/1973
Ditto
28
Ditto
292/1973
Condensation 30
Water: brines con-
taining small amounts
of organic chemicals
and possibly small
amounts of heavy
metal ions
Aminolysis
28
See Item 801
Sulfonation 15,28 Water: dilute sulfuric
Aminolysis acid and brine solu-
tions contaminated
with small amounts of
organic chemicals
Sulfonation
Aminolysis
15 See Item 805
28 See Item 801
14.6/1973
309/1973
15.5/1973
Aminolysis
Ditto
Sulfonation
28 See Item 801
28 Ditto
15 See Item 805
Nitrosation
Reduction
Sulfonation
33
Air: sulfur oxides,
nitrogen oxides &
hydrogen sulf ides
Water: spent acids
41/1973
(Continued)
521
-------
TABLE B-3. (Continued)
Compound Chem. Abitr.
Item Name and Registry No. Oral Toxicity.
No. Formula (WLN) '-^n' m9^k9 Toxicology TLV Carcinogen
815 CI63285 Disperse Blue 56 012217797
816 CI63365 Vat Violet 17 003076877
817 C 16361 5 Mordant Black 13 —
818 CI64500 Disperse Blue 1 002475458
819 CI64515 Acid Blue 81
820 CI65005 Acid Black 48 001328241
821 CI65049 Pigment
Yellow 123
822 CI65230 Vat Black 9
823 CI65430 Solubilized Vat
Yellow 10
824 CI6700VatRed 10 002379795
825 CI67300 Vat Yellow 2 000129099 —
826 CI67895 Vat Violet 14
827 C168210 Solvent Red 52
522
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Amide Formation 31
See Item 801
Sulfonation
Aminolysis
15,28 See Item 805
Amide Formation 32 See Item 800
104/1973
Sulfonation
Aminolysis
15,28 See Item 805
Ditto
Ditto Ditto
Amide Formation 31
Water: brines con-
taining small amounts
of organic materials
Condensation 34
Solid: copper salts,
sodium bromide &
distillation residues
Amide Formation 31
Reduction
Hydrolysis
Condensation 35
Cyclization
Reduction
Condensation 36
Purification
Aminolysis 28,12
Halogenation
Aminolysis 28
See Item 801 — — — —
Water: brines, spent — — — —
sulfuric acid and a
sodium thiosulfate
solution containing
small amounts of
organic chemicals
Solid: distillation
residues
Ditto — 1696/1973
Water: hydrogen — — — —
halide and small
amounts of highly
colored products &
brine with small
amounts of organic
chemicals
See Item 801 — — — —
(Continued)
523
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q. mg/kg
Toxicology
TLV
Carcinogen
828 CI68215 Acid Red 80 004478766
829 CI68420 Pigment
Yellow 108
830 CI68700Vat Violet 13
831 CI69005 Vat Black 27 002379819
832 CI69015 Vat Brown 3 000131920 —
833 CI69015 Pigment
Brown 28
000131920
834 CI69025 Vat Orange 15 002379784
835 CI69500 Vat Green 3 003271769
836 CI69501 Solubilized Vat 004471378
Green 3
837 CI69525 Vat Black 25 004395533
838 CI69705 Vat Yellow 21
524
-------
Process
(Sources
of Compound)
Halogenation
Sulfonation
Process
No.
12,15
Associated Wastes
Water: hydrogen halide,
dilute sulfuric acid.
Waste
Treatment
—
Total
Production
103 kg/year
Uses References
—
small amounts of
highly colored products
and brine solutions con-
taminated with small
amounts of organic
chemicals
Amide Formation 31
See Item 521
Aminolysis 28 See Item 501
Ditto 28 Ditto
Aminolysis 28,37 Water: sulfuric acid
Oxidation solutions containing
Cyclization small amounts of organic
Purification chemicals, and aqueous
Condensation solutions containing salt,
Filtration copper ion, chromium
ion, and sulfate ion
276/1973
171/1973
262/1973
Ditto
28,37
Oxidation
Cyclization
Purification
Condensation
Filtration
37
Ditto
336/1973
Aminolysis 28,34 Water: brines contain-
Cyclization ing small amounts of
Condensation organic chemicals
Solid: copper salts,
sodium bromide, and
distillation residues
— 604/1973
Sulfonation
15
See Item 805
Aminolysis
Cyclization
Condensation
28,34 See Item 835
— 1066/1973
Oxidation
Baking
22
See Item 724
(Continued)
525
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
839 CI69800 Vat Blue 4
000081776 200 rat
(T K6 16 F6
06 C666 BV
EM JV QV TM
B&VJ)
840 CI69805 Acid Dye 0
841 CI69810 Vat Blue 14 028675914
842 CI69810 Pigment Blue 22 028675914
843 CI69815Vat Blue 11 000130198
844 CI69825 Vat Blue 6 000130201 —
845 CI69825 Pigment Blue 64 000130201
846 CI69826 Solubilized Vat 002519280
Blue 6
847 CI69840Vat Blue 12 028675925 —
848 CI70315 Vat Dye 0
849 CI70320VatRed 13 004203774
850 CI70507 Vat Blue 67
851 CI70600 Vat Yellow 1 000475718
852 C170600 Pigment
Yellow 24
000475718
526
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Amide Formation
Purification
Filtration
38 Water: alkaline solu-
tions as well as
sodium sulfate
2)330,117
Sulfonation
Halogenation
15 See Item 805
12
Water: hydrogen
halide and small
amounts of highly
colored products
Ditto
12
Ditto
Halogenation
Ditto
Sulfonation
12 See Item 841
12 Ditto
15 See Item 805
890/1973
Ditto
15
Ditto
Diazotization 35 Air: nitrogen oxides
Reduction and possibly sulfur
Cyclization dioxide
Dimerization Water: spent acid &
Ethylation brine containing small
amounts of organic
materials
Ditto
35
Ditto
127/1973
Condensation
Viltration
38 Water: alkaline solu-
tions as well as
sodium sulfate
Ditto
38
Ditto
360/1973
(Continued)
527
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LDgo. mg/kg
Toxicology
TLV
Carcinogen
853 CI70800 Vat Brown 1 002475334
854 CI70801 Solubilized 023725157
Vat Brown 1
855 CI70805 Vat Orange 11 002172330
856 CI71050 VatGreenS 001499974
857 CI71100 Vat Red 15 004216028
858 CI71105 Pigment
Orange 43
004424060
859 CI71105 Vat Orange 7 004424060
860 CI71110 Vat Red 14
861 CI71129 Pigment Brown 26
862 CI71130 Vat Red 23 005521313
863 CI71130 Pigment Red 179005521313
864 CI71135 Vat Red 32 002379773
865 C171137 Pigment Red 149 012225024
528
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Waste
Treatment
Total
Production
103 kg/year
Uses
References
Condensation 39 Water: brines contain-
Cyclization ing copper & aluminum
ions, and small amounts
of organic compounds
Solid: distillation
residues
Sulfonation
15
Water: See Item 805
Condensation
Cyclization
39
See Item 853
Ditto
39
Ditto
102/1973
Amide Formation 40
Filtration
Water: effluents con-
taining organic chemi-
cals, acetic acid, o-
phenylenediamine,
ethanol, and potassium
hydroxide
Solid: distillation
residues
See Item 857
40 See Item 857
Amide Formation 41
Water: effluents con-
taining alkali, sodium
sulfate, and organic
compounds
Amide Formation -41
Methylation
Ditto
Ditto
41
Ditto
Condensation
Hydrolysis
Amide Formation
41 See Item 861
Ditto
41
Ditto
(Continued)
529
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN)
LD50,mg/kg
Toxicology
TLV
Carcinogen
866 CI71140 Pigment Red 190 006424777
867 C171140 Vat Red 29
006424777
868 CI71145 Pigment Red 123
869 CI71200 Var Blue 16 006424766
870 CI71205 Vat Blue 53
871 CI73000 Vat Blue 1
000482893
872 CI73000 D&C Blue 6 000482893
873 CI73015FD&CBIue2 000860220
(T56 BMYVJ
G SWQ C-21
& -NA-2)
TDLo:10gm/kg/
2YI,TFX:CAR
scu-rat
874 CI73015 Acid Blue 74 000860220
— Ditto
875 CI73065 Vat Blue 5
876 CI73300 Vat Red 41 000522758
877 CI73310 Pigment Red 87 006371115
878 CI73312 Pigment Red 88 014295433
530
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
See above item
41
See above item
Ditto
41
Ditto
Ditto
41
Ditto
Reduction
Condensation
Oxidation
26 Water: brines with
excess alkali, man-
ganese ion, or
aluminum ion and
organic substances
Solid: oxide sludge
Halogenation
12
See Item 841
Amide Formation 42
Filtration
Alkylation
Hydrolysis
Water: small amounts
of salts and organic
compounds
Ditto
42
Ditto
Sulfonation
15 Water: dilute sulfuric
acid and brine solu-
tions contaminated
with small amounts of
organic chemicals
37.7/1973
2)330,217
Ditto
15
Ditto
Ditto
Halogenation
12
See Item 841
Diazotization
Alkylation
Amide Formation
Oxidation
Substitution
43 Water: dilute alkali
solutions and also
sodium chloride &
small amounts of
organic chemicals &
nitrogen oxides
Solid: copper sulfide
Hydrolysis 45 Water: brine con tarn i-
Alkylation nated with varying
Cyclization amounts of organic
Herz Reaction chemicals & cyanide ion
Ditto
45
Ditto
(Continued)
531
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
879 CI73335 Vat Orange 5 003263318
880 CI73336Solubilized 010126871
Vat Orange 5
881 CI73360 Vat Red 1
002379740
882 CI73360 Pigment Red 181
883 CI73360 D&C Red 30 002379740
884 CI73361 Solubilized 003875727
Vat Red 1
885 CI73385 Vat Violet 2 005462293
886 C173385 Pigment
Violet 36
005462293
887 CI73390 Pigment Red 198
888 CI73395 Pigment
Violet 38
002379751
889 CI73395 Vat Violet 3 00237951
890 CI73410 Vat Brown 5 003989751 —
891 CI73670 Vat Black 1 003687670
892 CI73915 Pigment Red 122 012225002
532
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Hydrolysis
Alkylation
Cyclization
Herz Reaction
45 See Item 877
Sulfonation
15 See Item 873
See Item 877
45 See Item 877
141/1973
Ditto
45 Ditto
Ditto
45 Ditto
Sulfonation
15 See Item 873
See Item 877
45 See Item 877
Ditto
45 Ditto
Ditto
45 Ditto
Acid Chloride
Formation
Reduction
Alkylation
Cyclization
Oxidation
44 Water: dilute hydro-
chloric acid, phos-
phorus oxychloride,
aqueous zinc
chloride solution &
aluminum chloro-
hydrate solution
Solid: distillation
residues
Ditto
Ditto
Oxidation
Chlorination
Bromination
Condensation
44 Ditto
44 Ditto
46 Water: brines con-
taining small amounts
of organic chemicals
See Item 884
15 See Item 884
(Continued)
533
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDg0, mg/kg Toxicology TLV Carcinogen
893 CI73915 Pigment Red 122012225002
894 C174140 Vat Blue 29
895 CI74160 Beta Pigment 000147148
Blue 15
896 CI74160 Alpha Pigment 000147148
Bl Blue 15
897 CI74160 Ingrain Blue 2 000147148*
898 CI74160 Pigment 001330387"
Green 36
899 CI74180 Lake Pigment 001330387*
Blue 17
900 CI74180 Direct Blue 86 001330387
901 CI74200 Direct Blue 87
902 CI74240 Ingrain Blue 1
903 CI74260 Pigment Green 7 — —
904 CI74460 Reactive Blue 7 012238094
905 CI75290 Natural Black 1
534
-------
Process
(Sources
of Compound)
Process
No.
Associated Wastes
Waste
Treatment
Total
Production
103 kg/year
Uses
References
44.1/1973
Chlorination 47 Water: relatively large
Condensation amounts of waste sul-
Grinding furic acid and bright
Acid Pasting blue pigment. Also,
brines containing
aluminum ion &
small amounts of
organic chemicals
2880/1973
Ditto
47
Ditto
2033/1973
Ditto
Ditto
47
47
Ditto
Ditto
Sulfonation 15 Water: dilute sul-
furic acid & brine
solutions contami-
nated with small
amounts of organic
chemicals
Ditto
15
Ditto
493/1973
Ditto
15
Condensation 47
Chloromethylation
Ditto
See Item 895
Chlorination
Condensation
Grinding
Acid Pasting
47
Ditto
Condensation 47
Amide Formation
Reduction
Chlorosulfonation
Ditto
(Continued)
535
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD50' m9/k9 Toxicology TLV Carcinogen
906 CI75291 Lake Natural
Black 3
907 CI75330 Natural Red 6
908 CI75780 Natural Blue 1 — — —
909 CI76070 Oxidation Base 22 — — —
910 CI76075 Oxidation Base 8
911 CI76540 Oxidation Base 21 — — — — —
912 CI76555 Oxidation Base 25 — — — — —
913 CI77510 Pigment Blue 27
914 —Pigment Blue 23 — — — — —
915 — Pigment Red 91 — — — — —
916 —Pigment Red 170 — — — — —
917 —Pigment Red 177 004051632 — — — —
918 — Pigment Violet 74 — — — — —
919 — PMA Pigment Red 79
920 — Pigment Orange 38 — — — — —
921 — Pigment Yellow 85 — — —
922 — Vat Blue 39 — — — —
923 —Vat Blue 60
924 — Vat Brown 11
925 — Vat Green 32 — — —
926 — Vat Green 20
536
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
(Continued)
537
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abttr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
927 — Vat Brown 57
928 — Vat Brown 40
929 — Vat Brown 31
930 — Vat Brown 29
931 — Vat Brown 28
932 — Vat Brown 20
933 — Vat Brown 13
934 —Vat Brown 12
935 —Vat Black 13
936 — Vat Black 22
937 — Vat Black 34
938 — Vat Black 52
939 — Vat Black 38
940 — Vat Black 37
941 — Pigment Yellow 76
942 — Vat Violet 21
943 — Vat Red 12
944 — Vat Red 52
945 —Vat Red 16
946 — Vat Yellow 15
947 —Vat Yellow 33
948 — Vat Yellow 22
538
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
(Continued)
539
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
949 — Vat Yellow 14
950 — Leuco Sulfur Brown 82
951 — Leuco Sulfur Brown 81
952 —Solvent Yellow 13
953 —Solvent Yellow 40 —
954 — Solvent Yellow 45 —
955 — Solvent Yellow 44 002478208
956 —Solvent Yellow 43 012226969
957 —Solvent Yellow 42
958 — Mordant Black 26 —
959 — Mordant Black 8 —
960 — Mordant Brown 70 —
961 — Mordant Brown 63 —
962 — Mordant Orange 8 —
963 — Mordant Red 64 —
964 — Mordant Yellow 29 —
965 — Mordant Blue 19 —
966 — Ingrain Blue 3 —
967 — Fluorescent Brightener 159 —
968 —Fluorescent Brightener 158 —
969 —FD&CRed40 025956176
970 — Solvent Red 68 —
971 — Solvent Red 33
540
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
(Continued)
541
-------
TABLE B-3. (Continued)
Item
No.
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LDgg, mg/kg Toxicology
— Solvent Red 40 — — —
— Solvent Orange 51 — — —
— Solvent Orange 48 — — —
— Solvent Orange 20 — — —
— Solvent Orange 31 — — —
— Solvent Orange 25 — — —
— Solvent Orange 24 — — —
— Solvent Orange 23 — — —
— Solvent Yellow 107 — —
— Solvent Yellow 87 — — —
— Solvent Yellow 47 — — —
— Solvent Yellow 72 — — —
— Solvent Yellow 71 — — —
— Solvent Blue 9 — — —
— Solvent Blue 16 — — —
— Solvent Blue 57 — — —
— Solvent Blue 43 — — —
— Solvent Blue 38 — — —
— Solvent Blue 37 — — —
— Solvent Violet 17 — — —
— Solvent Red 166 — - — —
— Solvent Red 164 — — —
— Solvent Red 108
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
542
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
71.4/1973
(Continued)
543
-------
TABLE B-3. (Continued)
Item
No.
995
996
997
998
999
1000
1001
1002
1003
1004
1005
1006
1007
1008
1009
1010
1011
1012
1013
1014
1015
1016
1017
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LDgg, mg/kg Toxicology
— Solvent Red 1 26 — — —
— Solvent Red 115 — — —
— Solvent Red 105 — — —
— Solvent Red 75 — — —
— Solvent Red 74 — — —
— Solvent Red 69 — — —
— Solvent Blue 60 — — —
— Solvent Blue 58 — — —
— Solvent Blue 100 — — —
— Solvent Blue 98 — — —
— Solvent Blue 89 — — —
— Solvent Green 2 — — —
— Solvent Brown 11 — — —
— Solvent Brown 38 — — —
— Solvent Brown 22 — — —
— Solvent Brown 20 — — —
— Solvent Brown 19 — — —
— Leuco Sulfur Yellow 15 — — —
— Solvent Black 26 — — —
— Solvent Black 17 — — —
— Solvent Black 13 — — —
— Solvent Black 12 — — —
— Leuco Sulfur Brown 3 — — —
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
— —
—
—
—
—
— —
544
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
(Continued)
545
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) '-D50' m9^9 Toxicology TLV Carcinogen
1018 —Solubilized Sulfur — — — — —
Brown 37
1019 —Leuco Sulfur Brown 37 — — — — —
1020 —Leuco Sulfur Blue 5 — — — — —
1021 —Sulfur Blue 8
1022 —Leuco Sulfur Green 16 — — — — —
1023 —Sulfur Green 14 — — —
1024 —Pigment Green 38 — — — — —
1025 —Pigment Green 48 — — — — —
1026 — Pigment Brown 32 — — — — —
1027 —Acid Yellow 49 — — — —
1028 —Acid Yellow 59 001220529
1029 —Acid Yellow 19 — — — — —
1030 —Acid Yellow 79 — — — —
1031 —Acid Yellow 124 — — — — —
1032 —Acid Yellow 114 — — — —
1033 —Acid Yellow 152
1034 —Acid Yellow 174
1035 —Acid Yellow 159
1036 —Acid Yellow 135
1037 —Acid Yellow 129
1038 —Acid Yellow 128 — — — — —
1039 —Acid Yellow 127
1040 —Acid Orange 2 — — — —
546
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses References
199/1973
230/1973
(Continued)
547
-------
TABLE B-3. (Continued)
Item
No.
1041
1042
1043
1044
1045
1046
1047
1048
1049
1050
1051
1052
1053
1054
1055
1056
1057
1058
1059
1060
1061
1062
1063
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LD5o- m9/k9 Toxicology
— Acid Yellow 198
— Acid Yellow 190 — — —
— Acid Yellow 179
— Acid Yellow 1 75
— Acid Blue 69 006370623
— Acid Blue 63 — — —
— Acid Blue 122 — — —
— Acid Blue 165 — — —
— Acid Blue 198
— Acid Blue 179 — — —
— Acid Violet 29 — — —
— Acid Violet 76
— Acid Red 337
— Acid Red 309
— Acid Red 299 —
— Acid Red 278 — — —
— Acid Red 277 012220267
— Acid Red 266 — —
— Acid Red 225 — — —
— Acid Red 213
— Acid Red 21 2 — —
— Acid Red 211 012239053
— Acid Red 119 — — —
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
— —
—
—
—
—
— —
548
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
127/1973
60.0/1973
134/1973
(Continued)
549
-------
TABLE B-3. (Continued)
Item
No.
1064
1065
1066
1067
1068
1069
1070
1071
1072
1073
1074
1075
1076
1077
1078
1079
1080
1081
1082
1083
1084
1085
1086
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) '-'-'BO- m9/k9 Toxicology
— Acid Red 100 — — —
— Acid Red 167
— Acid Red 1 75 — — —
— Acid Red 178 — —
— Acid Red 182
— Acid Red 191
— Acid Red 194
— Acid Red 57
— Acid Orange 136 — — —
— Acid Orange 132 — — —
— Acid Orange 64 — — —
— Acid Orange 62 — — —
— Acid Orange 69 — — —
— Acid Orange 128 — — —
— Acid Orange 119 —
— Acid Orange 116 — — —
— Acid Orange 86 012220074
— Acid Black 29 — — —
— Acid Brown 354 — — —
— Acid Brown 243 — —
— Acid Brown 239 — — —
— Acid Brown 158 — — —
— Acid Brown 152 —
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
— —
—
—
—
—
—
—
—
—
—
— —
550
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
41.8/1973
270/1973
(Continued)
551
-------
TABLE B-3. (Continued)
Item
No.
1087
1088
1089
1090
1091
1092
1093
1094
1095
1096
1097
1098
1099
1100
1101
1102
1103
1104
1105
1106
1107
1108
1109
1110
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) L1-)50' m9/kg Toxicology
— Acid Brown 98 — — —
— Acid Brown 97 — — —
— Acid Brown 96 — — —
— Acid Black 172
— Acid Black 140 012219040 — —
— Acid Black 58 012218949
— Acid Black 53
— Acid Black 139
— Acid Black 108
— Acid Black 107 012218961
— Acid Black 92 — — —
— Acid Green 58 — — —
— Acid Green 84 — — —
— Acid Green 70 — — —
— Acid Brown 19 012234730 —
— Acid Brown 28 — —
— Acid Brown 22 —
— Acid Brown 58 — — —
— Acid Brown 51 — — —
— Acid Brown 45 012219544
— Acid Brown 31 — — —
— Acid Blue 221
— Acid Blue 215 014541903
— Acid Blue 203 — — —
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
552
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment ID"* kg/year Uses References
138/1973
553
-------
TABLE B-3. (Continued)
Item
No.
1111
1112
1113
1114
1115
1116
1117
1118
1119
1120
1121
1122
1123
1124
1125
1126
1127
1128
1129
1130
1131
1132
1133
Compound Chem. Abttr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LDgo, mg/kg Toxicology
— Acid Blue 298
— Acid Blue 231
— Azoic Brown 9 — — —
— Azoic Red 74
— Azoic Blue 2 — — —
— Azoic Blue 3 — — —
— Azoic Red 73 — — —
— Azoic Black 1 — —
— Azoic Brown 26 — —
— Azoic Black 15 —
— Azoic Black 4 — — —
— Basic Blue 35 — — —
— Basic Blue 22 — — —
— Basic Blue 21 — — —
— Basic Blue 45 — — —
— Basic Blue 45 — — —
— Basic Blue 47 012217435
— Basic Blue 76 — — —
— Basic Blue 75 — — —
— Basic Blue 69 — — —
— Basic Blue 60 — — —
— Basic Violet 24 — — —
— Basic Violet 15
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
554
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
160/1973
144/1973
(Continued)
555
-------
TABLE B-3. (Continued)
Item
No.
1134
1135
1136
1137
1138
1139
1140
1141
1142
1143
1144
1145
1146
1147
1148
1149
1150
1151
1152
1153
1154
1155
1156
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LDgQ, mg/kg Toxicology
— Basic Orange 41 — — —
— Basic Orange 40 — — —
— Basic Red 14
— Basic Orange 24 — — —
— Basic Orange 26 — — —
— Basic Orange 25 — — —
— Basic Orange 39 — — —
— Basic Orange 31 — — —
— Basic Orange 28 — — —
— Basic Orange 27 — — —
— Basic Red 73
— Basic Red 46 — — —
— Basic Red 51 — — —
— Basic Red 49 — — —
— Basic Red 23 — — —
— Basic Red 22 — — —
— Basic Red 19
— Basic Red 1 7 —
— Basic Red 16 — — —
— Basic Red 15 — — —
— Azoic Coupling 3 — — —
— Basic Yellow 15
— Basic Yellow 13
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
— —
556
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
— 175/1973
(Continued)
557
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abttr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
1157 — Basic Yellow 21
1158 —Basic Yellow 31
1159 — Basic Yellow 29
1160 — Basic Yellow 28
1161 — Basic Yellow 58
1162 —Basic Yellow 53
1163 —Basic Yellow 52
1164 —Basic Yellow 41
1165 — Salt Azoic Diazoic 121 —
1166 —Reactive Blue 21 —
1167 —Reactive Blue 38 012236907
1168 — Reactive Blue 30 —
1169 —Reactive Blue 29 —
1170 —Reactive Blue 25 —
1171 —Reactive Brown 17 —
1172 —Reactive Brown 10 —
1173 — Reactive Brown 9 —
1174 —Reactive Green 6 —
1175 — Reactive Blue 91 —
1176 — Reactive Blue 90 —
1177 — Reactive Blue 89 —
1178 —Reactive Blue 71
1179 —Reactive Blue 3 012239371
558
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
(Continued)
559
-------
TABLE B-3. (Continued)
Item
No.
1180
1181
1182
1183
1184
1185
1186
1187
1188
1189
1190
1191
1192
1193
1194
1195
1196
1197
1198
1199
1200
1201
1202
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) Ll->501 m9/k9 Toxicology
— Reactive Violet 1 — — —
— Reactive Red 105 — — —
— Reactive Red 94 — — —
— Reactive Red 86 — — —
— Reactive Red 58 02310978 —
— Reactive Red 55 027873627 —
— Reactive Red 43 — — —
— Reactive Red 41 012226185
— Reactive Red 40 012226174
— Reactive Red 33 — — —
— Reactive Red 31 — — —
— Fluorescent Brightener 49 — — —
— Fluorescent Brightener 45 — — —
— Fluorescent Brightener 33 — — —
— Fluorescent Brightener 25 — — —
— Fluorescent Brightener 24 — — —
— Reactive Black 9 — — —
— Fluorescent Brightener 22 — — —
— Fluorescent Brightener 8 — — —
— Fluorescent Brightener 6 — — —
— Fluorescent Brightener 134 — — —
— Fluorescent Brightener 130 — — —
— Fluorescent Brightener 128 — — —
TLV Carcinogen
—
— —
—
—
—
—
—
—
—
—
—
—
—
— —
—
—
—
—
—
— —
— —
—
—
560
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
(Continued)
561
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
1203 — Fluorescent Brightener 126 —
1204 — Fluorescent Brightener 125 —
1205 — Fluorescent
Brightener 114
012270518
1206 — Fluorescent Brightener 109 —
1207 — Fluorescent Brightener 108 —
1208 — Fluorescent Brightener 102 —
1209 — Fluorescent
Brightener 75
012226969
1210 —Fluorescent Brightener 71 —
1211 —Fluorescent Brightener 68 —
1212 —Fluorescent Brightener 61 —
1213 —Fluorescent Brightener 59 —
1214 —Fluorescent Brightener 52 —
1215 —Disperse Black 9 001222694
1216 —Disperse Black 34
1217 —Disperse Black 33 —
1218 —Reactive Yellow 4 012226458
1219 —Reactive Yellow 3 006539679
1220 — Reactive Yellow 2 016893484
1221 — Reactive Yellow 1 005089167
1222 — Disperse Brown 14 —
1223 —Disperse Brown 11 —
1224 —Disperse Brown 8 —
562
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
(Continued)
563
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
1225 — Disperse Brown 7 —
1226 —Disperse Brown 5 —
1227 —Disperse Brown 2 —
1228 —Disperse Blue 173
1229 —Disperse Blue 172
1230 —Disperse Blue 166
1231 —Disperse Blue 165
1232 —Disperse Blue 156
1233 —Disperse Blue 152
1234 —Disperse Blue 150
1235 — Disperse Blue 148
1236 —Disperse Blue 139
1237 —Disperse Blue 138
1238 — Disperse Blue 133
1239 —Disperse Blue 132 —
1240 —Disperse Blue 125
1241 —Disperse Blue 123
1242 —Reactive Yellow 15 —
1243 —Reactive Yellow 7 —
1244 —Reactive Yellow 6 012239484
1245 —Reactive Yellow 25 012226527
1246 —Reactive Yellow 24 012226516
1247 —Reactive Yellow 18
564
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
565
(Continued)
-------
TABLE B-3. (Continued)
Compound Chem. Abftr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LI-)50' m9^k9 Toxicology TLV Carcinogen
1248 —Reactive Yellow 17 020317195
1249 —Reactive Orange 5 — — — — —
1250 —Reactive Orange 4 — — — — —
1251 —Reactive Orange 1 006522743 — — —
1252 —Reactive Yellow 86
1253 —Reactive Yellow 62 — — — — —
1254 —Reactive Yellow 42 — —
1255 — Reactive Yellow 37 — — — --- —
1256 — Reactive Yellow 31 — — — —
1257 —Reactive Red 2 012226038 — — — —
1258 —Reactive Red 5 — — — — —
1259 —Reactive Red 11 — — — — —
1260 —Reactive Red 29 — — — — —
1261 —Reactive Red 21 — — — — —
1262 —Reactive Orange 50 — — — — —
1263 —Reactive Orange 49 — — — — —
1264 —Reactive Orange 14 012225864 — —
1265 —Reactive Orange 13 — — — — —
1266 —Reactive Orange 12 — — — — —
1267 —Reactive Orange 11 — — — — —
1268 —Disperse Violet 57 — — — — —
1269 —Disperse Violet 44 — — — — —
1270 —Disperse Violet 43 — — —
566
-------
Process T°tal
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
(Continued)
567
-------
TABLE B-3. (Continued)
Item
No.
1271
1272
1273
1274
1275
1276
1277
1278
1279
1280
1281
1282
1283
1284
1285
1286
1287
1288
1289
1290
1291
1292
1293
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LD5Q' m9/k9 Toxicology
— Disperse Violet 42 — — —
— Disperse Violet 41 — — —
— Disperse Violet 40 — — —
— Disperse Red 21 1 — — —
— Disperse Violet 17 — — —
— Disperse Violet 27 — — —
— Disperse Red 180 — — —
— Disperse Red 179 — — —
— Disperse Red 178 — — —
— Disperse Red 177 — — —
— Disperse Red 176 — — —
— Disperse Red 167 — — —
— Disperse Red 162 — — —
— Disperse Red 161 — — —
— Disperse Red 159 — — —
— Disperse Red 140 — — —
— Disperse Red 139 — — —
— Disperse Red 138 — — —
— Disperse Red 137 — — —
— Disperse Red 136 — — —
— Disperse Red 135 — — —
— Disperse Red 133 — — —
— Disperse Blue 60 — — —
TLV Carcinogen
— —
—
—
—
—
—
—
— —
—
—
—
—
— —
— —
— —
—
— —
— —
— —
— —
— —
— —
— —
568
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
— 86.4/1973
(Continued)
569
-------
TABLE B-3. (Continued)
Item
No.
1294
1295
1296
1297
1298
1299
1300
1301
1302
1303
1304
1305
1306
1307
1308
1309
1310
1311
1312
1313
1314
1315
1316
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LDgg, mg/kg Toxicology
— Disperse Blue 62 — — —
— Disperse Blue 61 — — —
— Disperse Blue 71 — — —
— Disperse Blue 70 — — —
— Disperse Blue 64 — — —
— Disperse Blue 8 — — —
— Disperse Blue 35 012222752
— Disperse Blue 55 — — —
— Disperse Blue 54 — — —
— Disperse Blue 121 — — —
— Disperse Blue 120 — — —
— Disperse Blue 119 — — —
— Disperse Blue 118 — — —
— Disperse Blue 117 — — —
— Disperse Blue 116 — — —
— Disperse Blue 112 — — —
— Disperse Blue 109 — — —
— Disperse Blue 102 — — —
— Disperse Blue 95 — — - —
— Disperse Blue 94 — — —
— Disperse Blue 87 — — —
— Disperse Blue 85 — — —
— Disperse Blue 81 — — —
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
570
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
214/1973
(Continued)
571
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q. mg/kg
Toxicology
TLV
Carcinogen
1317 —Disperse Blue 79 012239348
1318 —Disperse Blue 73 —
1319 —Disperse Red 35 —
1320 —Disperse Red 30 —
1321 —Disperse Red 21
1322 —Disperse Orange 98 —
1323 —Disperse Orange 94 —
1324 —Disperse Orange 91 —
1325 — Disperse Red 59
1326 —Disperse Red 55 —
1327 —Disperse Red 54
1328 — Disperse Red 78 —
1329 —Disperse Red 73 —
1330 Disperse Red 66
1331 —Disperse Red 65
1332 —Disperse Red 117 —
1333 — Disperse Red 105 —
1334 —Disperse Red 96
1335 —Disperse Red 91 —
1336 — Disperse Red 90
1337 — Disperse Red 88 —
1338 —Disperse Red 86
1339 — Disperse Red 82 —
572
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
— — — — 1645/1973
— 145/1973
(Continued)
573
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Regiftry No. Oral Toxicity,
No. Formula (WLN) LDgQ, mg/kg Toxicology TLV Carcinogen
1340 —Disperse Orange 16 — — — — —
1341 —Disperse Yellow 131 — — — — —
1342 —Disperse Yellow 125
1343 —Disperse Yellow 116 — — — —
1344 —Disperse Yellow 96 — — — — —
1345 —Disperse Yellow 95 — — —
1346 —Disperse Orange 41 — — — — —
1347 —Disperse Orange 38 — — — — —
1348 —Disperse Orange 37 — — — — —
1349 —Disperse Orange 30 — — — — —
1350 —Disperse Orange 29 — — — — —
1351 —Disperse Orange 25 — — — — —
1352 —Disperse Orange 21 — — — — —
1353 —Disperse Orange 17 — — — — —
1354 —Disperse Orange 90 — — — — —
1355 —Disperse Orange 89 — — — — —
1356 —Disperse Orange 80 — — — — —
1357 —Disperse Orange 79 — — — — —
1358 —Disperse Orange 78 — — — — —
1359 —Disperse Orange 77 — — — — —
1360 —Disperse Orange 75 — — — — —
1361 —Disperse Orange 67 — — — — —
1362 —Disperse Orange 66 — — — — —
574
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
371/1973
51.4/1973
(Continued)
575
-------
TABLE B-3. (Continued)
Item
No.
1363
1364
1365
1366
1367
1368
1369
1370
1371
1372
1373
1374
1375
1376
1377
1378
1379
1380
1381
1382
1383
1384
1385
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LD5Q, mg/kg Toxicology
— Disperse Orange 65 — — —
— Disperse Orange 62 — — —
— Disperse Orange 59 — — —
— Disperse Orange 58 — — —
— Disperse Orange 57 — — —
— Disperse Orange 44 — — —
— Disperse Orange 42 — — —
— Direct Blue 91 — — —
— Direct Blue 100 — — —
— Direct Blue 104
— Direct Blue 143 — — —
— Direct Blue 160 — — —
— Direct Blue 191 — — —
— Direct Blue 189 — — —
— Direct Green 69 — — —
— Direct Green 47 — — —
— Direct Green 45 — — —
— Direct Green 27 — — —
— Direct Blue 199 — — —
— Direct Blue 263 — — —
— Direct Blue 224 — — —
— Direct Blue 80 — — —
— Direct Blue 24 — — —
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
— —
—
—
576
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
52.7/1973
239/1973
(Continued)
577
-------
TABLE B-3. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LD5Q, mg/kg Toxicology TLV Carcinogen
1386 —Direct Violet 67 — — — — —
1387 —Direct Violet 99 — — — — —
1388 —Direct Blue 6 002602462
1389 —Disperse Yellow 34 — — — — —
1390 —Disperse Yellow 33 012223846
1391 —Disperse Yellow 32 — — — — —
1392 —Direct Black 95
1393 —Disperse Yellow 2 — — — — —
1394 —Direct Black 190 — — — —
1395 —Disperse Yellow 67 — — — — —
1396 —Disperse Yellow 69 — — —
1397 —Disperse Yellow 68 012223891 — — — —
1398 —Disperse Yellow 50 — — — — —
1399 —Disperse Yellow 58 — — — — —
1400 — Disperse Yellow 56 — —
1401 Disperse Yellow 93 — — — — —
1402 —Disperse Yellow 89 — — —
1403 —Disperse Yellow 88 — — — — —
1404 —Disperse Yellow 87 — — — — —
1405 —Disperse Yellow 86 — — — — —
1406 — Disperse Yellow 85 — — — — —
1407 —Disperse Yellow 77 — —
1408 —Disperse Yellow 74 012236338 — — —
578
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
54.1/1973
130/1973
(Continued)
579
-------
TABLE B-3. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
1409 — Direct Brown 48 —
1410 Direct Brown 11 —
1411 —Direct Brown 40 —
1412 —Direct Brown 1 003811710
1413 —Direct Black 37 —
1414 — Direct Black 44
1415 —Direct Brown 218 —
1416 — Direct Black 8 —
1417 —Direct Yellow 39 —
1418 —Direct Yellow 23
1419 — Basic Black 9
1420 —Basic Green 7 —
1421 —Basic Blue 97
1422 —Basic Green 3 —
1423 —Basic Blue 94
1424 — Basic Blue 87
1425 — Basic Blue 82
1426 —Basic Blue 77
1427 —Direct Yellow 63
1428 — Direct Yellow 105
1429 — Direct Yellow 103
1430 —Direct Yellow 84
1431 — Direct Yellow 81 —
580
-------
Process
(Sources Process
of Compound) No. Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
17.7/1973
119/1973
69.1/1973
(Continued)
581
-------
TABLE B-3. (Continued)
Item
No.
1432
1433
1434
1435
1436
1437
1438
1439
1440
1441
1442
1443
1444
1445
1446
1447
1448
1449
1450
1451
1452
1453
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LD5Q' m9/k9 Toxicology
— Direct Yellow 107
— Direct Yellow 117 — — —
— Direct Yellow 114 — —
— Direct Yellow 127 — — —
— Direct Yellow 120 — — —
— Direct Yellow 119
— Direct Yellow 118
— Direct Orange 1 1 — — —
— Direct Yellow 137 — — —
— Direct Yellow 133 — — —
— Direct Yellow 132 — — —
— Direct Yellow 131 — — —
Direct Red 100 — —
— Direct Red 139 — — —
— Direct Red 238 — — —
— Direct Red 236 — — —
— Direct Red 209 — — —
— Direct Red 95 — — —
— Direct Orange 59 — — —
— Direct Orange 72 — — —
— Direct Orange 67 — — —
— Direct Orange 81 — — —
TLV Carcinogen
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
582
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
311/1973
148/1973
(Continued)
583
-------
TABLE B-3. (Continued)
Item
No.
1454
1455
1456
1457
1458
Compound Chem. Abstr.
Name and Registry No. Oral Toxicity,
Formula (WLN) LDg0/ mg/kg Toxicology
— Direct Orange 80 — — —
— Direct Orange 79 — — —
— Direct Orange 78 — — —
— Direct Orange 110 — — —
— Direct Orange 88 — — —
TLV Carcinogen
—
584
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
585
-------
TABLE B-4. ADDENDUM
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) LDgg, mg/kg Toxicology TLV Carcinogen
30a CI11270 Solvent Orange 3 000532821*
54a CM2070 Dark Pigment 006410102*
Red 1
98a Cl 13091 Acid Orange 1
137a CI15530 Lake Pigment —
Orange 7
175a Cl 16150 Lake Acid 003761533*
Red 26
176a Cl 16180 Lake Acid 005858333*
Red 17
238a Cl 19140 Lake Acid 001934210*
Yellow 23
251 a CI20195 Pigment Acid
Brown 14
358a CI27201 Acid Red 115 006226808*
367a CI28160 Pigment Direct 002610119
Red 81
541a CI40001 Pigment Direct 001325377
Yellow 11
542a CI40001 Pigment Direct 001325388
Yellow 6
559a CI41000 Pigment Basic 002465272
Yellow 2
561a CI41001 Pigment Basic 006358367
Yellow 37
586
-------
TO TABLE B-3
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
Diazotization
Coupling
Water: inorganic salts
39.5/1973
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
See Item 30a
See Item 30a
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Ditto
Condensation
Precipitation
Filtration
Water: brines con-
taining small
amounts of
organic materials
Condensation
Precipitation
Filtration
Ditto
Condensation
Filtration
Precipitation
6,18
Water: brines con-
taminated with
small amounts of
organic materials,
residual amounts
of metal ions &
lead sulfate
Ditto
6,18 Ditto
90.9/1973
587
(Continued)
-------
TABLE B-4. (Continued)
Compound Chem. Abstr.
Item Name and Registry No. Oral Toxicity,
No. Formula (WLN) '-^50* m9^9 Toxicology TLV Carcinogen
563a CI42000 Fugitive Pigment 000569642*
Green 4
567a CI42025 Pigment Basic 003521060
Bluest
582a CI42090D&C Blue 1 002650182
592a CI42520 Pigment Basic 003248917
Violet 2
593a CI45235 Fugitive 000804873
Pigment Violet 3
619a CI42780 Lake Acid 028983564
Blue 93
632a CI45160 Lake Pigment 000989388
Red 81
636a C145170 Fugitive Pigment 001326030*
Violet 1
588
-------
Process
(Sources Process
of Compound) No.
Associated Wastes
Total
Waste Production
Treatment 10^ kg/year
Uses
References
Condensation
Oxidation
Crystallization
Filtration
Water: brines contami-
nated with small
amounts of organic
materials. Also, lead
sulfate is precipitated
as a solid waste
Condensation
Oxidation
Crystallization
Precipitation
Filtration
6,18
See Item 559a
See Item 563a
See Item 563a
2)330, 80
Oxidation 7
Filtration
Air: possibly signifi-
cant and hazardous
amounts of toxic
arylamines
Water: brines con-
taminated with vary-
ing amounts of
organic substances
Solids: sludges con-
taining large amounts
of metal ions
Oxidation
Filtration
Benzylation
Ditto
265/1973
Condensation
Cyclization
Oxidation
11 Water: brines con-
taminated with small
amounts of organic
chemicals
Solid: sludge of iron
oxide
Precipitation 11,18 Water: brines contami-
Filtration nated with small
Condensation amounts of organic
chemicals & residual
amounts of metal ions
Solid: sludge of iron
oxide
(Continued)
589
-------
TABLE B-4. (Continued)
Compound
Item Name and
No. Formula
Chem. Abitr.
Registry No. Oral Toxicity,
(WLN) LDgo, mg/kg
Toxicology
TLV
Carcinogen
655a CI45430 FD&C Red 3
000568638 1895 rat
(T C666 BO
EVJDI Fl IR
BVO& LI MO
NI&NA-2)
LDLo: 200 mg/kg,
ivn-rat
719a CI53290 Sulfur
Black 11
739a CI58055 Lake Pigment
Violet 5
746a CI59300 Pigment Vat 004378614
Orange 3
749a CI59710 Pigment Vat 001324330
Orange 4
857a CI71100 Pigment Vat 004216028
Red 15
858a C171105 Pigment Vat 004424060
Orange 7
910a CI76076 Oxidation
BaseS
590
-------
Process
(Sources Process
of Compound) No.
Precipitation 12,18
Filtration
Halogenation
Waste
Associated Wastes . Treatment
Water: halide and —
small amounts of
highly colored pro-
ducts and residual
amounts of metal ions
Total
Production
103 kg/year
155/1973
Uses References
Condensation
22 Water: brines con-
taining inorganic sul-
fur compounds &
small amounts of
organic chemicals
70/1973
Halogenation
Ditto
12
12
Water: hydrogen
halide and small
amounts of highly
colored products
Ditto
Amide Formation 40
Filtration
Water: effluents con-
taining organic chemi-
cals, acetic acid,
o-phenylenediamine,
ethanol, and potassium
hydroxide
Solid: distillation
residues
(Continued)
591
-------
TABLE B-5. ORGANIC DYES AND PIGMENTS, INORGANICS-TOXICITY
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD5Q, mg/kg
Toxicology
TLV
Carcinogen
1 Alumina hydrate
Aluminum acetate
3 Aluminum sulfate
010043013
(AL2 S-02-
Q2*3)
LD50:270 mg/kg,
ipr-mus
4 Ammonium bisulfite
(Ammonium hydrogen
sulfite)
5 Ammonium molybdate 013106768 333 rat
No cases of human
poisoning have
been reported
USDS air: TWA
10.2 mg/m3
6 Arsenic trioxide
001327533 20 rat
(.As2.03)
A rodenticide
USDS air: TWA
0.5 mg/m3
7 Barium chloride
010361372
(BA G2)
LD50:54 mg/kg,
ipr-mus
USDS air: TWA
806 ug/m3
USDS air: TWA
0.5 mg/m3
8 Boric acid
010043353 2660 rat
(QBQQ)
TDLo:8gm/kg/
50WTFX:NEO
ivg-mus
9 Chlorosulfonic acid
007790945
(HS-03G)
— Highly toxic
10 Chromium fluoride
LDLo:150
mg/kg gpg
11 Chromium formate
12 Chromium sulfate
010101538
(CR2 S-02-
0.2*3)
LDLo:85 mg/kg
13 Cobalt acetate
000071487
(WV1 & QV1
&-CO-)
LD50:25 mg/kg,
ivn-rbt
14 Copper (powder)
592
-------
PROCESS, WASTE, PRODUCTION AND USE DATA
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year
Uses
References
3)373
2)59
3)377
3)463
2)750
3)393
2)126
3)422,420
2)148
3)432
2)231
3)467
2)320
3)555,1134
2)328
3)559
3)559
2)328
3)559
2)16
3)574
593
-------
TABLE B-5. (Continued)
Compound
Item Name and
No. Formula
Cham. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
15 Copper ferrocyanide
16 Cupric chloride
001344678 140 rat
Used as a herbicide
USOS air: TWA
1 mg/m3
17 Cupric oxide
Ditto
18 Hydrochloric acid 007647010 900 rbt
USOS air: TWA
5 ppm
19 Iodine
007553562 LDLo:2000
(11) hmn
USOS air: TWA
0.1 ppm
USOS air: TWA
1 mg/m3
20 Iron (scrap)
Iron compounds,
suspected
carcinogens
21 Lead carbonate (basic) 000598630
(QVQ & -PB-)
USOS air: TWA
258 ug/m3
22 Lead peroxide
001309600
USOS air: TWA
230 ug/m3
23 Magnesium oxide (fume) 001309484
TCLo:400mg/m3
TFX:UNS ihl-hmn
USOS air: TWA
10 mg/m3
24 Manganese chloride
007773015
(MN G2)
LDLo:210 mg/kg,
scu-mus
LD50:121 mg/kg,
ipr-mus
25 Manganese dioxide 001313139 —
LDLo:45 mg/kg,
ivn-rbt
26 Mercuric oxide
001344452 18 rat
Highly toxic
USOS air: TWA
0.05 mg/m3
27 Nickel acetate
000373024 350 rat
(QVI & 2
-NI-)
USOS air: TWA TDLo:350 mg/kg/
3 mg/m3 43WI,TFX:CAR
ims-rat
28 Raney nickel catalyst 007440020
(.Nl)
TDLo:15mg/m3/
91WI,inh-gpg
USOS air: TWA TDLo:15 mg/kg/
1 mg/m3 6WI,TFX:NEO
scu-rat
594
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 10^ kg/year Uses References
595
2)344
3)573
3)575
2)619
3)816
2)645
3)18,832
3)836
2)677
3)861
Ditto
2)686
3)19,880
2)690
3)885
2)690
3)885
3)19,895,
900
2)790
3)954
2)790
(Continued)
-------
TABLE B-5. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50, mg/kg
Toxicology
TLV
Carcinogen
29 Oleum(sulfuricacid)
007664939
(WSQQ)
2140 rat TCLo:800 ug/m3
TFX:MTH, ihl-hmn
TCLo:350 ug/m3
TFX:PUL, ihl-hmn
USOS air: TWA
1 mg/m3
30 Phosgene
000075445
(GVG)
TDLo:25ppm/30M
TFX.-IRR, ihl-hmn
LC50:75ppm/
30M, ihl-rat
31 Phosphomolybdic acid
32 Phosphorus oxychloride 010025873 380 rat
(POGB)
Highly toxic
33 Phosphorus pentachloride 010026138 660 rat
(PG5)
LCLo:120ppm
ihl-mus, highly
caustic
USOS air: TWA
1 mg/m3
34 Phosphorus trichloride 007719122 550 rat
(PG3)
LCLo:600 ppm/10M USOS air: TWA
ihl-mus 0.5 ppm
USOS air: TWA
3 mg/m3
35 Phosphotungstic acid,
sodium salt
1600 rat
36 Potassium carbonate
(anhydrous)
001303726 LDLo:160
mg/kg rat
Strong caustic
37 Potassium hydroxide
001310583 365 rat
(KAQ)
USOS air: TWA
2 mg/m3
38 Potassium permanganate 007722647 1090 rat
(.KA.. MN-04)
39 Sodium bisulfite
007631905
(NA S-O-QZ)
Highly toxic
LD50:650 mg/kg,
ipr-rat
40 Sodium bromate
007789380
(NA E-02-Q)
LD50:140 mg/kg,
ipr-mus
41 Sodium chlorate
007775099 LD Lo: 1500 Used as an herbicide
(NAG-02-Q)
596
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
2)1096
3)985
2)887
3)1021
2)924
3)1025,816
2)897
3)1025,816,
21
2)924
3)1027,816,
21
2)924
3)1027
2)950
3)1042
2)951
3)1047,21
2)846
3)1051
2)1062
3)1104,1131
2)234
3)471
2)306
3)1105
(Continued)
597
-------
TABLE B-5. (Continued)
Compound
Item Name and
No. Formula
Chem. Abstr.
Registry No. Oral Toxicity,
(WLN) LD50. mg/kg
Toxicology
TLV
Carcinogen
42 Sodium hyposulfite
43 Sodium nitrite
007632000 85 rat
(NA N-O-Q)
44 Sodium thiosulfate
Most thiosulfates
have low toxicity
45 Stannous chloride
007772998
(SN G2)
700 rat
USDS Air: TWA
3.2 mg/m3
46 Strontium chloride
010476854
(.SR..G2)
LD50:908 mg/kg,
ipr-mus
47 Sulfamic acid
005329146 1600ug/kg
(2SWQ) rat
48 Sulfur
007704349
(S)
Very low
49 Sulfur chloride
010025679
(S2 G2)
LCLo:150ppm/1M USDS air: TWA
ihl-mus 1 ppm
USOS air: TWA
6 mg/m3
50 Sulfur monochloride 010025679 —
LCLo:150ppm/1M Ditto
ihl-mus
51 Sulfuryl chloride
007791255
(S 02 G2)
Corrosive
52 Thionyl chloride
007719097
(S O G2)
Very toxic material
and constitutes
serious toxic
hazards
53 Zinc
Not toxic unless
heated
54 Zinc chloride
007646857
UN..G2)
Fumes are highly USOS air: TWA TDLo:17 mg/kg
toxic 1 mg/m3 TFX:NEO, par-
TCLo:4800 mg/m3/ ham
30MTFX:PULihl-man
LDLo:30 mg/kg,
ivn-rat
598
-------
Process Total
(Sources Process Waste Production
of Compound) No. Associated Wastes Treatment 103 kg/year Uses References
— — 3)111,1131
2)801
3)962,1114
3)1120
2)1133
3)1124
2)1082
2)1088
3)1130
2)1096
3)1132
2)1096
3)1132,21
Ditto
2)1098
3)1136
2)1126
3)1166
3)1252
2)1206
3)1251,22
599
-------
APPENDIX C
KEY TO ABBREVIATIONS AND ACRONYMS USED
IN TABLES IN APPENDICES A AND B
abs - absorptions(s)
agn- - agent (s)
air - allergenic effect(s)
aqtx - aquatic toxicity
BCM - blood clotting mechanism
effects
bdw - wild bird species
BLD - blood effect(s)
BPR - blood pressure effect(s)
brd - bird (domestic or lab)
C - continuous
cc - cubic centimeter
CL - ceiling concentration
CAR - carcinogenic effect(s)
cat - cat
chd - child
chem - chemicals
concen - concentration(s)
ckn - chicken
CNS - central nervous system
effects
COR - corrosive effects
ctl - cattle
CRIT DOC- criteria document
CUM - cumulative effects
CVS - cardiovascular effects
D - day
dck - duck
DDP - drug dependence effects
DEF - definition
dog - dog
EYE - eye effects
frg - frog
GIT - gastrointestinal tract
effects
GLN - glandular effects
gm - gram
gpg - guinea pig
H - hour
ham - hamster
hmn - human
inc - including
I - intermittent
IARC - International Agency for
Research on Cancer
ial - intraaural
iat - intraarterial
ice - intracerebral
icv - intracervical
idr - intradermal
idu - intraduodenal
ihl - inhalation
imp - implant
ims - intramuscular
ind - industry, industrial
inf - infant
ing - ingestion
int - intermediate
ipc - intraplacental
ipl - intrapleural
ipr - intraperitoneal
irn - intrarenal
irr - irritant effects
isp - intraspinal
itr - intratracheal
ivg - intravaginal
ivn - intravenous
ingred - ingredient(s)
insec - insecticide(s)
inhib - inhibitor(s)
kg - kilogram (one thousand grams)
L - local
lacq - lacquer
LC50 - lethal concentration 50
percent kill
LCLo - lowest published lethal
concentration
LD50 - lethal dose 50 percent kill
LDLo - lowest published lethal dose
mam - mammal (species unspecified)
man - man
M - minute
mtrl - material(s)
muc - mucous
m^ - cubic meter
mfg - manufacturing
600
-------
ABBREVIATIONS
(Continued)
mfr - manufacturer
mg - milligram (one thousandth of
a gram; 10"3 gm)
mky - monkey
mmi - mucous membrane effects
msk - muscolo-skeletal effects
mth - mouth effects
mem - membrane
mus - mouse
MUT - mutagenic effects
NEO - neoplastic effects
ng - nanogram (one billionth of a
gram; 10~9 gm)
ocu - ocular
orl - oral
org - organic
par - parenteral
photo - photography, photograhic
pg - picogram (one trillionth
of a gram; lO"-^ gm)
pgn - pigeon
pig - pig
pk - peak concentration
PNS - peripheral nervous system
effects
ppb - parts per billion (v/v)
pph - parts per hundred (v/v)
(percent)
ppm - parts per million (v/v)
ppt - parts per trillion (v/v)
prep - preparation(s)
psy - psychotropic
pul - pulmonary system effects
pharm - Pharmaceuticals
qal - quail
rat - rat
RBC - red blood cell effects
rbt - rabbit
rbr - rubber
rec - rectal
rec'd - recommended
scu - subcutaneous
skn - skin
skn abs- skin absorption
SKN
sql
syn
sup
S
solv
TCLo
skin effects
squirrel
synthetic(s), synthesis
super script
systemic effects
solvent(s)
- lowest published toxic
concentration
TDLo - lowest published toxic dose
TER - teratogenic effects
TFX - toxic effects
TLV - threshold limit value
tox rev- toxicology review
trk - turkey
TWA - time weighted average
TXDS - qualifying toxic dose
U - unknown
ug - microgram (one millionth of
a gram; 10~6 gm)
unk - unreported
uns - toxic effects unspecified in
source
USDS - U.S. Occupational Health
Standard
W - week
wbc - white blood cell effects
WLN - Wisswesser Line Number
wmn - woman
Y - year
* - indicates closely related
derivative of the Chem.
Abst. Registry No. shown,
such as a salt, free acid,
free base or lake
601
-------
APPENDIX D
INDUSTRIAL ORGANIC CHEMICALS - POSSIBLE ADDITIONS TO THE MASTER LIST
TABLE D-l. RADIAN LIST OF COMPOUNDS TO BE ADDED TO THE
LIST OF INDUSTRIAL ORGANIC CHEMICALS(a>
Radian
Number
125
185
190
235
290
785
905
950
951
995
1021
117(7
1200
1230
1495
1530
1545
2091
2145
2165
2210
2261
2321
2455
2665
2756
2757
Compound Name
Acetyl chloride
Adiponitrile
Alkyl naphthalenes (methyl)
p-Aminophenol (c)
Amy 1 phenol
Caprolactam
Chlorobenzotrichloride (o, p)
o-Chloronitrobenzene
p-Chloronitrobenzene
Chlorotrifluoromethane
Cresols, mixed
Cyclooctadiene
m-Dichlorobenzene
l,2-Dichloroethane(d)
Dimethylhydrazine
Dimethyl terephthalate
2 , 4-Dinitrophenol ( f )
Glycerol dichlorohydrin
Hexachlo rob enz ene
Hexamethylenediamine
p-Hydroxybenzo ic ac id ( g )
Isobutylene 00
Isopentane
Metanilic acid^i'
Methyl methacrylate
o-Nitroaniline ( J )
p-Nitroaniline 00
WLN(b)
GV1
NC4CN
L66J C
ZR DQ
QR X5
T7MVTJ
GXGGR XC
WNR BG
WNR DG
GXFFF
QR X
L8U CUTJ *C *C
GR CG
G1U1G
ZN1&1
10VR DV01
WNR BQ ENW
Q1YG1G
G 6-R
Z6Z
QVR DQ
1YU1
2Y
ZR CSWQ
1UYV01
ZR BNW
ZR DNW
(Continued)
602
-------
TABLE D-l. (Continued)
Radian
Number
2930
3270
3349
3354
3355
3395
Compound Name
Phenylanthranilic acid^^
Tannic acid^m'
Toluene
2 , 4-Toluenedissocyanate
Toluene diisocyanate
1,1, 1-Trichloroethane
WVR
IR
OCNR
OCNR
GXGG
wu,<»
BMR
B ENCO
X XNCO
(a) Radian list of compounds added to OCPDB (reference 12) and supplied
to Battelle on 6/2/76.
(b) Wiswesser Line Notation.
(c) Item No. 645, Table B-2 (ODP-I).
(d) Compound meant to be ethylene dichloride; WLN - G1G1.
(e) See under Item No. 374, Table A-l (IOC).
(f) Item No. 667, Table B-2 (ODP-I).
(g) Item No. 18, Table B-l (ODP-R).
(h) Item No. 64, Table A-l (IOC).
(i) Item No. 318, Table B-2 (ODP-I).
(j) Item No. 97, Table B-2 (ODP-I).
(k) Item No. 98, Table B-2 (ODP-I).
(1) Item No. 333, Table A-l (IOC).
(m) Item No. 30, Table B-l (ODP-R).
603
-------
TABLE D-2. INDUSTRIAL ORGANIC CHEMICALS NOT ON THE IOC LIST OR ON
TABLE E-l - FROM A 1975 PETROCHEMICAL COMPILATION(a)
Compound Name WLN
Acrylates'k) —
(Methyl acrylate) 10V1U1
(n-Propyl acrylate) 30V1U1
(2-Ethyl hexyl acrylate) 4Y2&10V1U1
Isophthalonitrile NCR CCN
Lactic acid QYVQ
Linear alkyl benzenes ^c' —
DL-Methionine QVM2S1
Peracetic acid QOV1
Propylene carbonate T50VOTJ D
Tetrahydrofuran T50TJ
Xylylene diisocyanate OCNR X X XNCO
(a) IOC = Industrial Organic Chemicals. Compounds are taken
from Hydrocarbon Processing (]975 Petrochemical Handbook
issue), .54 (11), 76 D - 76 W & 97-98, November, 1975,
published by Gulf Publishing Co., Houston, Texas.
(b) Other acrylate esters may also be of sufficient importance
to consider adding. Ethyl and n-butyl acrylates are
already on the IOC list.
(c) Higher alkyl benzenes other than those already listed
(toluene and ethyl benzene are on the IOC list); also some
branched alkyl benzenes are commercial and should be added.
604
-------
TABLE D-3. 1973 U.S. TARIFF COMMISSION REPORT
COMPOUNDS NOT ELSEWHERE LISTED(a)
1973
Production,
Compound MM/lb
-------
TABLE D-4. ADDITIONAL COMPOUNDS TO BE CONSIDERED
FOR INCLUSION IN IOC TABLE A-l(a)
Benzidine
tert-Butyl hydroperoxide
Caprolactone
Tris(2,3-Dibromopropyl phosphate)
Dichloromethyl ether
Cyclohexanone oxime
Dimethyl acetamide
Dimethyl carbamoyl chloride (*>/
Ethyleneiminee
Hexahydrophthalic anhydride
Hexamethyl phosphoric acid
triamide (HMPT)(b)
3-Hexanone
8-Hydroxystearic acid
Lauryl alcohol
Methyl-n-amyl ketone
Methylene diisocyanate (MDI)
(p,p'-diphenylmethane diisocyanate)
Nadic methyl anhydride
Paraformaldehyde
2-Pentanone
Piperidine
Stearic acid
Terephthalonitrile
Trimethylolpropane
s-Trioxane
Vinyl pyridines
(a) Randomly identified compounds that are now or have been commercially
produced.
(b) Recently identified as potent carcinogens (Chemical Week,
June 2, 1976, page 31).
-------
TABLE D-5. COMPOUNDS NOT ALREADY INCLUDED WHICH ARE
COVERED BY EFFLUENT LIMITATIONS GUIDELINES
DEVELOPMENT DOCUMENTS - ORGANIC CHEMICAL
INDUSTRY^
Ace tin
(Glyceryl monoacetate)
n-Butyl propionate
Calcium citrate
Calcium oxalate
Calcium stearate(b'
Calcium tartrate
Chloral
(Trichloroacetic aldehyde)
Chloroprene
Citral
Citric acid
CitronellolOO
Coumarin
Dichloroethyl sulfide
(mustard gas)
Ethyl nitrite
Geraniol(b)
Hydrazine solutions(b)
^- '
Methyl ionone(b)
Methyl salicylate(b)
Monosodium glutamate
Oxalic acid
Pentachlorophenol
Saccharin
Silicones
(Chlorosilanes)
Sodium citrate
Sodium pentachlorophenate
Tartaric acid
Terpineol
Thioglycolic acid
Tricresyl phosphate
Tridecyl alcohol
Triphenyl phosphate
Vanillin
(a) Compounds not already included in IOC Table A-l or pre-
ceeding Tables 2-5.
(b) Compounds on the effluent guidelines priority list, i.e,
recommended standards published in EPA-440/1-74-0099,
April 1974 and EPA-440/1-75/045, November 1975.
607
-------
TABLE D-6. ORGANIC CHEMICALS IN REFERENCE 1 BUT WITH NO
PROCESS NUMBER - POSSIBLE ADDITIONS TO THE
IOC
Aniline
o-Benzoylbenzoic acid^ '
Bis(Chloroisopropyl) ether
Cobalt toluate
Cresol ether
Diallyl ether
Diamyl sulfide
2,4-Dimethyl-l-l,3-dioxane
Ethyl formate
Ethyl phenanthrene
Furfural
Glycidaldehyde
Hexane
Isobutane
Methane
Methyl bromide
Methyl iodide
Naphthalene sodium sulfonate
o-Nitroanisole^0'
Oxalic acid
Pentachloroethane
Phenanthrene
a-Phenylethyl alcohol
Sodium ethoxide
Sodium glycolate
Sodium stearate
Stilbene
Terphenyl
2,4,6-Trichlorophenol
Trinitrophenol (Picric acid)
(a) Thirty-four organic chemicals are listed which appear in
Chapter 6 reference (1) IPPEU-IOC, but which do
not have process number assignments. These compounds
should be considered for inclusion in the catalog as
primary entrants and for addition to the list of compounds
on which toxicity and process data are being assembled.
(b) Item No. 397, page B-33, Table B-2 (ODP-I).
(c) Item No. 123, page B-13, Table B-2 (ODP-I).
608
-------
APPENDIX E
INDUSTRIAL ORGANIC CHEMICALS - EXTRACTION TABLES'BASED ON TOXICITY AND PRODUCTION
VOLUME DATA IN TABLE A-l
TABLE E-l. U.S. OCCUPATIONAL STANDARD (USOS) FOR CONCENTRATIONS IN AIR - INDUSTRIAL ORGANIC CHEMICALS
[Listed alphabetically according to compound]
Compound
Number
3
7
8
9
11
14
15
17
19
20
24
26
30
32
(a)
Concentration ,
ppm
200
10
5
1000
40
0.1
0.3 mg/m3 (skn)(b)
20 (skn)
2 (skn)
1
100
100
5 (skn)
3
0.5 mg/m (skn)
Compound
Number
39
48
49
54
56
57
60
61
65
66
67
68
69
70
(a)
Concentration ,
ppm
10
0.1
1
1
0.2
0.5
1000
. .
500
150
200
200
150
100
CL 5 (skn)
Compound
Number
71
72
73
79
84
85
86
94
101
111G
111
112
113
(a)
Concentration ,
ppm
150
500
5
10
20, CL 30,
PK 100/30M/8H
( r 1
O 1
10 (skn)
75
50
5 (skn)
5 (skn)
5 (skn)
5 (skn)
(Continued)
-------
TABLE E-l. (Continued)
Compound
Number
114
116
122
123
124
125
126
129
133
134
135
137
143
160
161
163
(a)
Concentration ,
ppm
2
50
300
50
50
300
10 (skn)
50
CL 50
75
1000
CL 15 (skn)
25
10
5 (skn)
10 (skn)
Compound
Number
164
167
168
176
178
179
185
187
188
189
191
192
193
194
196
201
(a)
Concentration ,
ppm
1
1 mg/m (skn)
1 mg/m (skn)
100 (skn)
3
10 mg/m
1
5 (skn)
1000
3
400
25
10
100
200
1000
5 (skn)
Compound
Number
202
203
204
205
211
213
214
216
217
221
222
227
228
229
232
(a)
Concentration ,
ppm
10
20, CL 30,
PK 50/5M/8H
50
100, 260 mg/m3(c)
50 (skn)
200 (skn)
100 (skn)
25 (skn)
25 (skn)
50
400
3, CL 5,
PK 10/30M/8H
20
5
10 mg/m3(c)
(Continued)
-------
TABLE E-l. (Continued)
Compound
Number
238
242
243
244
245
248
249
255
258
259
260
263
265
267
270
273
(a)
Concentration ,
ppm
1 (skn)
25<0
10 (skn)
3
2 mg/m
100
100
150
25
250
400
5
0.5
0.25
25
1 (skn)
200
Compound
Number
275
276
277
279
280
281
282
284
286
287
288
289
292
294
295
(a)
Concentration ,
ppm
200
10
2 (skn)
100, CL 200,
PK 300/5M/3H
500
100
100 (skn)
500, CL 1000,
PK 2000/5M/2H
200
100
25
100
CL 100
20 (skn)
10
Compound
Number
302
306
307
310
311
312
313
314
322
323
327
328
331
336
337
(a)
Concentration ,
ppm
1 (skn)
100
100
25
25
5 (skn)
5 (skn)
5 (skn)
10'mg/m3(c)
1000
100, CL 200,
PK 300/5M/3H
0.1
5 (skn)
0.1 mg/m (skn)
0.1
(Continued)
-------
TABLE E-l. (Continued)
Compound
Number
338
347
350
355
356
ON
1— '
357
358
368
(a)
Concentration ,
ppm
2
1000
200
75
100
5
io(c)
100, CL 200,
PK 600/5M/3H
Compound
Number
377
387
391
392
393
394
395
397
Concentration ,
ppm
117/yg/m3 (skn)
5 (skn)
10 (skn)
100, CL 200,
PK 300/5M/2H
1000
50
1000
25
Compound
Number
403
404
405
406
407
408
409
415G
(a)
Concentration ,
ppm
10
1
10
100
100
100
100
5
, CL 5
(0
CM
\C)
(c)
(c)
(skn)
(a) Time weighted average (TW) unless indicated otherwise.
(b) (skn) indicates additional absorption through the skin is possible even when the concentration is
below the indicated standard.
(c) Not necessarily USDS.
-------
TABLE E-2. U.S. OCCUPATIONAL STANDARD (USOS) FOR CONCENTRATIONS IN AIR - INDUSTRIAL ORGANIC CHEMICALS
[Listed according to increasing standard concentrations]
Concentration (a) ,
ppm
0.1
0.2
O.l(c)
0.1
0.1
0.2
0.2
0.25
0.5
0.5
0.5
1
1
1
1
If G if n 1 \*^J
\ o ixii y
1
1 (skn)
1 (skn)
1 (skn)
Compound
Number
14
48
85
328
337
7
56
265
8
57
263
20
49
54
164
168
179
238
270
302
Concentration (a) ,
ppm
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
10
10
10
10
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
(skn)
Compound
Number
111G
111
112
113
161
185
201
229
260
312
313
314
331
357
387
415G
7
39
79
86
Concentration (a) ,
ppm
10(c)
CL 15 (skn)
(skn)
20
20
20
20 (skn)
25
25 (skn)
25 (skn)
25
-------
TABLE E-2. (Continued)
<^
Concentration (a' ,
ppm
1
2 (skn)
2
2 (skn)
2
3
3
5
5 (skn)
CL 5 (skn)
5
100
100
100
100
100 (skn)
100
ioo
-------
TABLE E-2. (Continued)
Concentration (a) ,
ppm
100
100
100
100 (skn)
100
100
CL 100
100
100
100
100
100
100
Compound
Number
248
279
281
282
287
289
292
306
307
327
356
368
392
Concentration (a' ,
ppm
200
200
200
200 (skn)
200
200
200
200
250
300
300
400
400
Compound
Number
66
67
194
213
273
275
286
350
258
122
125
222
259
Concentration (a) ,
ppm
1,000
1,000
1,000
0.1 (skn)
0.117 (skn)
0.3 (skn)
0.5 (skn)
1 (skn)
1 (skn)
10
I0(c)
I0(c)
Compound
Number
347
393
395
336
377
15
32
167
168
178
232
322
(a) Time weighted average (TWA) unless indicated otherwise.
(b) (skn) indicates additional absorption through the skin is possible even when the concentration
is below the indicated standard.
(c) Not necessarily USOS.
-------
TABLE E-3. HUMAN TOXICITY DATA - INDUSTRIAL ORGANIC CHEMICALS
Compound
Number^3)
3
7
9
ii
14
it
17
19
24
30
39
"
44
54
56
60
62
64
79
ii
80
TDLo TCLo
134 ppm
816 ppm/3M
500 ppm
12,000 ppm/4H
1 ppm
-
16 ppm/20M
25 ppm
188 ppm/30M
-
-
210 ppm
6 mg/kg
16 ppm
4400 mg/m3
-
25 ppm
200 ppm
10 ppm/3M
20 ppm/5M
580 mg/m3
LDLo LCLo TFX
IRR
IRR
EYE
CNS
IRR
153 ppm/lOM
PUL
IRR
IRR
350 mg/kg
20,000 ppm/5M
BID
SKN
UNS
IRR
250,000 ppm/25M
PUL
IRR
IRR
CNS
IRR
Adm(b>
ihl
ihl
ihl
ihl
ihl
ihl
ihl
ihl
ihl
orl
ihl
ihl
skn
ihl
ihl
ihl
ihl
ihl
ihl
ihl
ihl
(Continued)
-------
TABLE E-3. (Continued)
Compound
Number'3'
84
ti
86
ii
90
101
114
123
124
132
134
163
176
185
187
ii
"
193
196
201
202
TDLo TCLo LDLo
_
50 mg/m3/7Y
20 ppm
_
44 mg/m3
10 ppm/lY
12 mg/m3/10M
100 ppm
50 ppm
25 p.g/m3
300 mg/kg
200 ppm
_
20 ppm
2000 mg/kg
6000 mg/kg
50 mg/kg
1,000 ppm
13,000 ppm
5000 mg/kg
200 ppm
LCLo TFX
4,000 ppm/30M
CNS
CNS
1,000 ppm
BID
SYS
IRR
MMI
IRR
EYE
UNS
CNS
470 ppm
EYE
-
-
GIT
IRR
CNS
SKN
IRR
Adm(b)
ihl
ihl
ihl
ihl
ihl
ihl
ihl
ihl
ihl
ihl
orl
ihl
ihl
ihl
orl (chd)
orl
orl
scu
ihl
skn
ihl
(Continued)
-------
TABLE E-3. (Continued)
ON
M
00
Compound
Number'3)
204
ti
205
211
216
227
ii
243
ii
259
ii
275
ii
ii
284
ii
290
ii
295
302
311
320
TDLo TCLo
-
4,000 ppm/H
-
195 ppm/8H
25 ppm
-
13.8 ppm
-
-
-
400 ppm
300 ppm
-
100 mg/kg
500 ppm/lYI
500 ppm/8H
7 mg/kg
70 mg/kg
-
200 mg/kg
15 ppm
14 mg/kg
LDLo
845 mg/kg
-
1500 mg/kg
-
-
36 mg/kg
-
750 M,g/kg
-
2371 mg/kg
-
-
340 mg/kg
-
-
-
-
-
100 mg/kg
-
-
-
LCLo TFX
-
CNS
-
IRR
CNS
-
IRR
-
120 mg/m3/lH
-
IRR
CNS
-
EYE
CNS
BID
PSY
CNS
-
BID
CNS
PSY
Adm(b)
orl
ihl
orl
ihl
ihl
orl (wmn)
ihl
orl
ihl
orl
ihl
ihl
orl
orl
ihl
ihl
orl
orl
orl (chd)
orl (wmn)
ihl
orl
(Continued)
-------
TABLE E-3. (Continued)
ON
Compound
Number (b)
320
n
n
323
327
n
n
328
"
331
"
337
350
367
368
"
"
n
392
n
TDLo
14 mg/kg
71 mg/kg
14 mg/kg
-
-
-
-
-
-
14 mg/kg
-
25 ppm/30M
-
-
-
-
-
-
-
-
TCLo
-
-
-
130,000 ppm
230 ppm
280 ppm/2H
600 ppm/lOM
45 ppm
-
-
-
-
-
-
-
600 ppm
376 ppm
20 mg/m3
160 ppm/83M
110 ppm/8H
LDLo LCLo TFX
PSY
PSY
PSY
CNS
SYS
EYE
CNS
EYE
483 ppm/lOM
GIT
140 mg/kg
IRR
5700 mg/kg
5000 mg/kg
10,000 ppm/30M
IRR
CNS
GLN
CNS
-
w>
ivn
ims
rec
ihl
ihl
ihl
ihl
ihl
ihl
orl
orl
ihl
orl (wmn)
unk
ihl
ihl
ihl
ihl (wmn)
ihl
ihl
(Continued)
-------
i-o
o
TABLE E-3. (Continued)
Compound
Number (fe) TDLo
395
404
TCLo LDLo
4500 ppm
20 ppm
LCLo TFX
CNS
CVS
W>
ihl
ihl
(a) Item number of compound in Industrial Organic Chemicals table.
(b) Method of administration (see list of abbreviations and acronyms).
-------
TABLE E-4. CARCINOGENS OR SUSPECTED CARCINOGENS - INDUSTRIAL ORGANIC CHEMICALS
Compound
Number (a'
1
5
21
35
36
36
39
48
54
54
86
86
86
86
86
86
101
106
117
117
121
121
123
134
137
141
141
144
156
156
156
164
164
176
178
185
185
187
187
205
227
TDLo
600 gm/kg/YI
456 gm/kg/52W
8400 mg/kg/84DI
16 mg/kg/24WI
90 gm/kg/90DC
72 gm/kg/90D
1232 mg/kg/52W
2000 mg/kg/28WC
50 mg/kg
2100 mg/kg/5lWI
4800 mg/kg/88DI
133 gm/kg/25WI
3680 mg/kg/30WI
159 gm/kg/25WI
159 gm/kg/20WI
120 mg/kg/88DI
18 gm/kg/120DI
48 gm/kg/12WI
304 mg/kg
10 gm/kg/76WI
22 gm/kg/73WI
18 mg/kg/73W
Suspected carcinogen-hmn
142 mg/kg/I
33 gm/kg/79WIC
2404 mg/kg/48WI
2400 mg/kg/44W
Suspected carcinogen of the
bladder-hmn
1900 mg/kg/81WI
800 mg/kg/49WI
50 mg/kg
—
50 mg/kg
416 gm/kg/57WC
Recognized carcinogen-hmn
19 mg/kg
720 mg/kg/ 18WI
340 gm/kg/57WI
100 gm/kg/18WI
4 gm/kg
1300 mg/kg/65WI
TCLo
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
17 mg/m3/18WI
—
—
—
—
—
—
—
—
—
TFX
NEO
CAR
NEO
NEO
NEO
NEO
CAR
NEO
NEO
NEO
CAR
NEO
CAR
CAR
CAR
CAR
CAR
NEO
NEO
NEO
NEO
NEO
—
CAR
CAR
NEO
CAR
—
CAR
NEO
CAR
CAR
NEO
CAR
—
NEO
NEO
CAR
CAR
NEO
NEO
Adm- Animal ^ '
skn-mus
orl-rat
orl-rat
orl-rat
orl-rat
orl-rat
skn-mus
skn-mus
scu-rat
scu-rat
orl-mus
scu-rat
orl-ham
scu-rat
rec-mus
orl-mus
orl-mus
skn-mus
ihl-mus
scu-mus
orl-rat
unk-rat
—
scu-mus
orl-mus
scu-mus
scu-mus
—
orl-rat
scu-rat
scu-rat
ihl-rat
scu-rat
orl-rat
—
ihl-mus
scu-mus
orl-mus
rec-mus
skn-mus
scu-rat
(Continued)
621
-------
TABLE E-4. (Continued)
Compound
Number^3'
241
265
285
285
295
320
328
329
330
331
344
356
363
367
377
382
386
387
392
404
404
404
410
411
412
413
414
414
TDLo
144 gm/kg/72WI
610 mg/kg/61W
80 mg/kg
1410 mg/kg
3500 mg/kg/98DI
12 gm/kg/W
—
Recognized carcinogen-hmn
Recognized carcinogen-hmn
4000 mg/kg/ 20WI
420 gm/kg/Y
TDLo: 1500 mg/kg/46WI
8600 mg/kg/ 19WI
2600 mg/kg/65W
86 mg/kg/28DI
11 gm/kg/36WC
6.6 mg/kg/ 19WI
870 mg/kg/ 78WC
351 gm/kg/78WI
—
—
Liver carcinogen, mam, 500
ppm/4YI
5600 mg/kg/28WI
5600 mg/kg/28WI
5600 mg/kg/28WI
5600 mg/kg/28WI
4000 mg/kg/ 120WI
64,000/mg/kg/20WI
TCLo TFX
NEO
CAR
CAR
NEO
NEO
NEO
15 mg/m3/68WI CAR
—
'"' •
CAR
CAR
NEO
NEO
CAR
CAR
CAR
NEO
NEO
CAR
250 ppm/4H/260DI CAR
250 ppm/35WI CAR
CAR
CAR
CAR
CAR
NEO
NEO
NEO
Adm- Animal (b)
scu-rat
scu-rat
orl-rat
scu-rat
scu-rat
skn-mus
ihl-rat
—
—
skn-mus
ivg-mus
scu-rat
scu-rat
scu-rat
scu-mus
orl-rat
orl-rat
orl-rat
orl-mus
ihl-rat
ihl-mus
ihl-man
skn-mus
skn-mus
skn-mus
skn-mus
skn-mus
skn-mus
(a) Item number of compound in Industrial Organic Chemicals table.
(b) Method of administration and animal (see list of abbreviations and
acronyms).
622
-------
TABLE E-5. TERATOGENS AND MUTAGENS
Item
No.
IOC
86
IOC
101
IOC
156
IOC
164
IOC
166
Compound Mutagen Teratogen
carbon tetrachloride TCLo:300 ppm
(6-15D preg)
TFX:TER, ihl-rat
chloroform TCLo:100 ppm/7H
(6-15D preg)
TFX:TER, ihl-rat
diethyl sulfate TDLo:85 mg/kg
(15D preg),
TFX:TER, ivn-rat
dimethyl sulfate TDLo:20 mg/kg
(15D preg),
TFXrTER, ivn-rat
dimethyl sulf oxide TDLo:5 gm/kg
(6-12D preg),
TFX:TER, orl-rat
Carcinogen
potent
animal
carcinogen,
orl
animal
carcinogen,
orl
potent
carcinogen
orl or scu
potent
carcinogen
ihl or scu
IOC
178
diphenylamine
TDLo:8 gm/kg
(6-12D preg),
TFX:TER, ipr-rat
TDLo:50 rag/kg
(8D preg),
TFX:TER, ivn-ham
TDLo:7500 mg/kg
(17-22D preg),
TFX:TER, orl-rat
recognized
carcinogen
(Continued)
-------
TABLE E-5. (Continued)
Item
No.
IOC
187
IOC
204
IOC
221
IOC
228
IOC
286
IOC
406
IOC-ADD (&)
7
IOC-ADD
18
IOC-ADD
29
Compound Mutagen
ethanol
ethylene dichloride experimental
Mutagen 3)658
ethylene oxide TDLo:30 mg/m3
TFXrMUT, ihl-man
formamide
methyl ethyl ketone
vinyl toluene
2,6-di-tert
butyl-p-cresol
chloroprene TDLo:39 mg/m3/4H/
48D
TFX:MUT, ihl-rat
N,N-dimethyl
acetamide
Teratogen Carcinogen
TDLo:7500 mg/kg animal
(9D preg) carcinogen,
TFXrTER orl or rec
experimental experimental
teratogen 3)658 carcinogen
3)658
TDLo:6 gm/kg
(11-160D preg)
TFX:TER, ipr-rat
TDLo:1000 ppm
(6-15D preg)
TFX:TER, ihl-rat
TCLo:29 mg/m3/13WI
TFX:TER
ihl-gpg
TDLo:5500 mg/kg
(preg)
TFX:TER, orl -rat
TDLo:600 mg/kg
(preg)
TFX:TER, ipr-rat
(Continued)
-------
TABLE E-5. (Continued)
ON
Ui
Item
No.
IOC-ADD
42
IOC- ADD
65
177
DPD
280
DPD
316
Compound Mutagen
hexachlorobenzene
methyl salicylate
CI 16185 Acid
Red 27
CI 22120 Direct
Red 28
CI 23850 Direct
Blue 14
Teratogen
TDLo:500 mg/kg
(7-11D preg)
TFXrTER, orl-mus
TDLo:500 mg/kg
(6 preg)
TFX:TER, scu-rat
LDLo:1500 y/kg
(preg)
TFX:TER, orl-rat
TDLo:80 mg/kg/
(8D preg)
TFX:TER, unk-rat
TDLo:25 mg/kg/
(8D preg)
TFX:TER, scu-mus
Carcinogen
yes
orl-rat
potent
carcinogen
scu-rat
(a) IOC-ADD are industrial organic chemicals-addendum (cf Table A-2, Appendix A)
(b) Dye and pigment dye (cf Table B-3).
-------
TABLE E-6. ORAL TOXICITY (LD50, ORAL-RAT) VERSUS PRODUCTION
VOLUME, WASTE AND CARCINOGEN DATA - IOC
Rating
Order
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
IOC Item
Number (a)
10
166
14
19
20
137
89
364
17
328
185
201
48
112
203
15
175
72
375
113
354
111
140
270
173
251
104
414
12
90
114
290
358
394
244
LD50, Carcin-
mg/kg ogen(b)
1 to 50 (e)
17
20 T
46
51 to 100
54
64
75 +
76
76
82
83 +
90 +
95
101 to 300
120 +
121
140
170
177
180
200
207
220
242
250
250
268
280
288
296 +
300
300
300
300
301 to 500
301
320
320
1973 Production(c) ,
MM kg
245/1969
—
28/1974
__
395/1970
—
29.1/1969
—
614.8
—
81.7
—
__
11.2
150.3
18.2
—
508.5
—
—
—
—
—
—
—
—
64/1974
—
1.0
—
—
—
11.8/1970
—
8.1
Waste^)
W A
+
—
+
+ +
+
—
—
—
+
—
+
+
.
—
+
—
—
—
+
—
—
+
—
-4-
+
+
+
+
(Continued)
626
-------
TABLE E-6. (Continued)
Rating
Order
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
IOC Item
Number (a)
221
16
285
309
141
71
117
297
192
225
291
384
331
346
30
164
411
397
416
27
265
121
138
70
83
133
134
404
412
165
143
159
105
392
49
413
132
106
204
160
174
264
LD50 , Carcin-
mg/kg ogen(b)
330 M
340
347 +
350
373 +
380
382 +
400
400
400,
400
400
414 +
419
440
440 +,T
444 +
460
467
470
481 +
485 +
490
500
500
500
500 +
500 +
500 +
501 to 700
535
540
560
570
580
600
608 +
648
670 +
680
698
701 to 1000
707
708
1973 Production(c) , WasteW
MM kg W A
1890
59.7 -- +
91
— —
— —
205.6
— —
__ —
25.2/1972 +
—
— —
+
1019
38.8
207.8 +
— —
— —
+
— —
__ —
128 + +
—
— —
58.1 +
— —
— —
28.5
2432
—
_— — —
5/1972 +
—
+
193.0/1974 +
—
— —
— —
— —
4210 +
55.2
_— __
(Continued)
627
-------
TABLE E-6. (Continued)
Rating
Order
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
IOC Item
Number ^a^
142
126
73
390
202
70
6
101
227
260
191
418
91
156
41
312
357
360
387
356
415
307
284
386
115
191
294
321
31
314
306
267
172
229
51
54
219
417
263
37
245
33
348
LD50, Carcin-
mg/kg ogen^b)
710
710
735
756
760
790
800
800 +
800 +
820
830
840
880
880 +, T
890
891
891
891
900 +
930 +
933
940
945
974 +
1,000
1001 to 1500
1,020
1,050
1,070
1,072
1,072
1,100
1,120
1,122
1,210
1,230
1,231 +
1,260
1,297
1,300
1 , 300
1,300
1,400
1,400
1973 Production^0), Waste(d)
MM kg W A
48.3
— —
1.82 +
— —
30/1974 +
235.5 +
1.8
115 +
2918 +
— —
125.1 + +
— —
— —
—
—
— —
3.4/1968
18.9 +
— —
797 +
— —
— —
236 + +
— —
—
125 + +
—
—
—
—
—
—
+
24.2 +
5.9
36.5/1972 +
—
—
—
—
—
0.9
— — —
(Continued)
628
-------
TABLE E-6. (Continued)
Rating
Order
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
IOC Item
Number (a)
288
111G
211
215
254
79
349
320
102
372
124
316
281
53
222
8
295
340
350
355
3
304
235
123
103
289
188
284
184
282
313
4
255
299
216
248
80
298
42
250
308
LD50,
mg/kg
1,410
1,454
1,480
1,480
1,480
1,500
1,510
1,530
1,540
1,540
1,620
1,620
1,660
1,700
1,700
1,780
1,780
1,860
1,870
1,900
1,930
1,960
2,000
2,060
2,078
2,080
2,100
2,136
2,140
2,140
2,144
2,180
2,330
2,420
2,460
2,460
2,490
2,590
2,710
2,810
2,828
Carcin-
—
—
—
—
—
—
1501 to 2000
—
+
—
—
—
—
—
—
—
—
+
—
—
—
—
—
—
2001 to 3000
+
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
1973 Production^0) , Wasted
MM kg W A
15.9
26.1 +
62.4 +
—
22.4 +
— —
27.4 +
+
—
—
289.7 +
49 +
—
—
33 +
758.2 +
272.6
—
42.1 +
—
657.2/1972 + +
—
—
325.5/1968
—
70.3 +
40.2
236 +
—
—
—
—
—
—
39.1 +
60.2
216 +
— —
— —
— —
+
(Continued)
629
-------
TABLE E-6. (Continued)
Rating
Order
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
IOC Item
Number (a)
378
94
116
224
403
81
177
23
213
274
283
24
25
44
223
410
55
78
207
56
7
179
217
286
69
193
361
34
68
11
39
145
190
129
88
242
338
57
362
127
208
35
2
LD50,
mg/kg
2,860
2,910
2,910
2,920
2,920
2,940
3,000
3,000
3,000
3,000
3,000
3,030
3,030
3,040
3,200
3,200
3,249
3,250
3,250
3,280
3,310
3,370
3,390
3,400
3,500
3,500
3,530
2,700
3,730
3,800
2,800
3,900
3,980
4,000
4,000
4,000
4,020
4,040
4,100
4,170
4,390
4,620
4,700
Carcin- 1973 Production (c ), Waste(d)
ogenW MM kg W A
__ —
180.5 +
1210
—
683 + +
+
—
—
86.5 +
—
—
3001 to 5000 (e)
5.4 +
—
36.8/1974 +
182.5 +
+
—
—
—
2.3/1971
1104
—
—
246 +
—
2580
—
—
38 +
+
+
—
—
—
378.9
20.9
465
145 + +
5.4
+
—
+
— — — — —
(Continued)
630
-------
TABLE E-6. (Continued)
Rating
Order
205
"206
207
208
209
210
211
212
213
IOC Item LD50,
Number (a) mg/kg
301 4,700
128 4,720
220 4,890
292 4,900
152 4,920
392 4,920
368 5,000
407 5,000
409 5,000
(a) Item number of compound in
(b) A
plus (+) indicates that
Carcin- 1973
ogen(b)
—
—
—
—
—
+
—
—
—
Industrial Organic
this compound is a
Production(c),
MM kg
—
—
—
23.8
—
205
2716
2627/1974
1057
Waste(d)
W A
—
—
—
—
—
+
+ +
—
—
Chemicals Table A-l.
known or suspected
carcinogen; M indicates mutagen; and T indicates teratogen.
(c) A dash (—) indicates no production data available. A number followed
by a year indicates no 1973 data, but instead data for another year.
(d) Quantitative waste data on specific compounds available. W = effluent
data, and A = air or emissions data.
(e) There are 32 compounds (item numbers) with LD50-orl, rat >5000 mg/kg
not shown on this table.
631
-------
TABLE E-7. ORAL TOXICITY (LD50, ANIMAL OTHER THAN RAT VALUES ^ 500 mg/kg)
VERSUS PRODUCTION VOLUME, WASTE AND CARCINOGEN DATA - IOC
u>
Rating
No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
IOC
Item No. 'a'
167
388
265
340
41
383
19
25
74
160
91
227
331
368
314
202
413
LD50
mg/kg Carcinogen '")
42 bdw
42 bdw
60 mus +
65 mus —
75 bdw
75 bdw
96
200 mus
225 dog
240 rbt
316 mus
256 mus
260 gpg +
300 mus +
316 mus
330 mus
470
477 mus +
1973 Production,
MM kg
—
128
—
—
—
—
—
—
55
—
2918
1019
—
—
30
—
Waste^)
W A
+ +
(a) Item number of compound in Table A-l. Two compounds (167, 383) do not have
any oral-rat data. IOC's 19, 265, and 331 have LD50 oral-rat data < 500
mg/kg. The other 14 compounds have LD50, oral-rat values > 500 mg/kg.
(b) A plus (+) indicates the compound is a known or suspected carcinogen.
(c) Quantitative waste data on specific compounds in effluent (W) and air or
emissions (A) are available for marked (+) compounds.
-------
TABLE E-8. ORAL TOXICITY (LDLo, ALL ANIMALS) VERSUS PRODUCTION
VOLUME, WASTE AND CARCINOGEN DATA - IOC
Rating
Order
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
IOC
Item No. (a)
377
168
334
235
336
350
132
259
310
277
387
236
271
311
382
412
LDLo,
rag/kg
17 rat
29 cat
80 rat
100 rat
140 mus
113 cat
192 mus
250 rbt
280 rbt
300 cat
500 rbt
500 mus
500 rat
500 rat
500 rat
1973 Production Waste
Carcinogen MM kg W A
+ 160 +
—
—
— —
—
42 +
+
—
—
17
+
204
—
— —
+ 88 +
+
(a) Item number of compound in Industrial Organic Chemicals Table A-l.
Only the 16 compounds that do not have LD50, orl-rat data <_ 500 mg/kg
are shown. There are a total of 24 compounds that do not have LD50
orl-rat.
(b) A plus (+) indicates this compound is a known or suspected carcinogen.
(c) A minus (-) indicates no production data.
(d) Quantitative waste data on specific compounds in effluent (W) and air
emissions (A) available.
(e) Special note-human data.
633
-------
TABLE E-9. INHALATION LC50 DATA VERSUS CARCINOGEN,
PRODUCTION, AND EMISSION DATA
-------
Footnotes for Table E-9.
(a) All compounds with inhalation lethal concentration, 50 percent test
animal population data from Table A-l.
(b) Approximate ordinal ranking based on inhalation toxicity (i.e, in order
of lowest lethal concentrations); different exposure times/animals
makes ranking only approximate.
(c) Parts per million/hours/animal. Blank spaces indicated data not
available. Data in parentheses are milligrams/cubic meter.
(d) Carcinogen or neoplasm (M = mutagen).
(e) Specific compound quantitative emission data in Table A-l in Ib/ton. No
quantitative effluent data are available on these compounds.
Cf) 1974.
635
-------
TABLE E-10.
TOXICITY DATA £ 500 MG/KG OR = 1000 PPM
NOT INCLUDED IN TABLES F-6 THROUGH F-9 ~
ANY ANIMAL OR ADMINISTRATION ROUTE
IOC
Item
No.
3
4
8
17
20
21
46
49
57
83
85
86
88
90
105
126
127
133
137
138
140
152
156
164
176
180
185
192
201
203
204
211
227
229
230
263
267
268
LDLo:
LD50:
LCLo:
LCLo:
LCLo:
LDLo:
LDLo:
LDLo:
LD50:
LCLo:
LD50:
LDLo:
LDLo:
LDLo:
LD50:
LD50:
LCLo:
LCLo:
LCLo:
LCLo:
LCLo:
LD50:
LD50:
LCLo:
LCLo:
LCLo:
LD50:
LCLo:
LD50:
LCLo:
LCLo:
LDLo:
LCLo:
LCLo:
LCLo:
LD50:
LD50:
LCLo:
LCLo:
LD50:
Toxic Dose, Carcin-
mg/kg(fl) ogen
500 ipr-rat
140 skn-rat
1000 ppm/4H, ihl-rat
500 ppm/4H, ihl-rat
290/8H, ihl-rat
500 ipr-mus +
180 scu-mus
125 ppm/4H, ihl-rat
150 ipr-mus
400 ppm, ihl-rat
298 scu-mus -
125 mg/kg, ivn-dog +
4 ipr-mus
310 scu-cat
355 ipr-rat
200 ipr-rat
500 ppm/2H, ihl-rat
707 ppm/7H, ihl-rat
1000 ppm/45M, ihl-rat +
125 ppm/4H, ihl-rat
260 ppm, ihl-rat
150 skn-rbt
340 ivn-rat +
250 ppm/4H, ihl-rat
75 ppm/17M, ihl-mus +
470 ppm, ihl-hmn +
500 ipr-mus
250 ppm/4H, ihl-rat +
390 dkn-rbt
32 ppm/4H, ihl-rat
400 ppm/2H, ihl-rat
500 scu-rat
1000 ppm/4H, ihl-rat
500 ppm/4H, ihl-rat
250 ppm/4H, ihl-rat +
145 ivn-mus
200 ipr-mus
53 ppm/100 M, ihl-rat
1000 ppm/4H, ihl-rat
49 ipr-mus
1973
Production
MM kg
657
-
758
615
395 (b)
-
-
-
145
-
-
476
-
-
-
-
-
34
-
-
-
-
-
-
7
229
25
-
4210
62
2918
-
-
-
-
31
Waste
W A
+ +
- -
+
I +
-
+
-
+ +
-
-
-
-
-
+
+
+
+
-
-
-
-
-
-
-
+
- +
-
+
+
+
-
+
-
-
— —
(Continued)
636
-------
TABLE E-10. (Continued)
IOC
Item Toxic Dose,
No. mg/kg(a)
273 LCLo: 67 mg/m3/56M, ihl-cat
284 LDLo: 200 ivn-dog
294 LD50: 500 skn-rbt
295 LD50: 150 ipr-mus
299 LDLo: 100 scu-mus
302 LDLo: 150 ivn-dog
308 LDLo: 100 ivn-dog
311 LCLo: 714 ppm/5H, ihl-cat
327 LDLo: 85 ivn-dog
331 LD50: 250 ipr-rat
LD50: 344 scu-mus
354 LCLo: 500 ppm/4H, ihl-rat
361 LD50: 335 ivn-mus
375 LCLo: 1000 ppm/4H, ihl-rat
378 LCLo: 275 ppm/8H, ihl-gpg
386 LD50: 150 ipr-mus
391 LD50: 227 scu-mus
LCLo: 500 ppm/8H, ihl-rat
392 LDLo: 150 ivn-dog
394 LCLo: 1000 ppm/4H, ihl-rat
397 LCLo: 1000 ppm/4H, ihl-rat
403 LDLo: 500 ipr-rat
405 LDLo: 225 ivn-dog
(a) Chemical administration units
otherwise indicated in table;
ihl-animal .
(b) 1970.
(c) 1971.
1973
Carcin- Production
ogen MM kg
_ _
236
- -
+ 164
-
140
-
-
321
+ 1019
-
- -
-
+
170 (c)
+ 205
-
13
683
77
in mg chemical/kg body weight
Waste
W A
_ —
+
-
-
-
-
+
-
-
+ +
-
— *4~
-
-
+
+
-
+
-
+
unless
inhalation data given in ppm/time,
637
-------
oo
TABLE E-ll. TOTAL PRODUCTION - INDUSTRIAL ORGANIC CHEMICALS
[Listed alphabetically according to compound]
Compound
Number (a)
3
6
7
8
9
10
11
12
13
14
15
16
17
18
20
23
24
30
33
39
44
Total Production, millions of kg (millions of pounds)
Earlier Years 1972 1973
657.2 (1447.6)
1.8 (4.0
1014.9 (2235.4) 1104 (2429)
758.2 (1670)
904 (1989)
245.2 (540) - -
68 (150)"
1.0 (2.2)
_
18.2 (40)
59.7 (131.6)
614.8 (1354.2)
711 (1567)
395 (870) -1970
- - -
5.4 (12)
207.8 (457.6)
0.9 (2.0)
5130 (11,300)
_
1974
_
-
1033.7 (2580) 954
800 (1760) 651
900 (1980) 723
-
_
1.2 (2.7)
230.2 (507)
27.7 (61)
-
431 (948) inclesters
642 (1412) 552
754 (1630) 668
-
6.1 (13.5)
-
250 (551) 187
-
4587 (10,091) 3482
36.8 (81)
1975
-
-
(2100)
(1520)
(1591)
-
—
-
-
-
(1215)
(1470)
-
-
-
(412)
-
(7660)
-
(Continued)
-------
TABLE E-ll. (Continued)
Compound
Number (a'
160
161
172G
176
178
181
185
187
188
189
191
192
193
195
196
199
202
203
204
205
206
Total Production, millions of kg (millions of pounds)
Earlier Years 1972 1973
55.2 (121.5)
7.1 (15.7)
_
7.4 (16.2)
15.7 (34.7)
24.2 (53.3)
229 (503)
890 (1961.8)
141 (310)
100.5 (221.5)
125.1 (275.5)
25.2 (55.5)
2580 (5688)
2.9 (6.5)
299.7 (660.1)
-
-
150.3 (331.1)
4210 (9292.7)
1485 (3277.6)
2.8 (6.1)
1974
-
-
237.6 (522.8)
-
-
-
-
862.6 (1900)
89.1 (196)
-
139 (305)
-
-
10,859 (23,890)
30 (66)
-
3496.3 (7701)
1518 (3340)
-
1975
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2700 (5940)
1727 (3800)
-
(Continued)
-------
TABLE E-ll. (Continued)
to
Compound
Number 'a'
211
213
216
221
222
223
227
229
230
232
236
239
241
242
243
244
248
249
250
253
Total Production, millions of kg (millions of pounds)
Earlier Years 1972 1973
62.4 (137.8)
86.5 (190.3)
39.1 (86.2)
1890 (4167)
32.8 (72.4)
182.5 (402.3)
2918 (6424.1)
24.2 (53.1)
24.3 (53.5)
94.4 (208)
(synthetic
only)
204 (450) - 1967
45.7 (100.7)
45.7 (100.7)
10.9 (23.9)
138.1 (304.3)
8.1 (17.9)
60.2 (132.8)
5.3 (11.75)
_ - -
79.2 (174.3)
1974
-
72.2 (159.0)
-
1765 (3888)
27.2 (60)
-
2654.0 (5845.8)
-
19.1 (42)
161.8 (356.3)
-
-
-
-
-
-
-
173.6 (381.9)
81.7 (180)
1975
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
(Continued)
-------
TABLE E-ll. (Continued)
Compound
Number^3'
47
51
53
54
56
57
60
62G
62
65
66
68
70
71
72
73
80
84
86
87
Total Production, millions of kg (millions of pounds)
Earlier Years 1972 1973 1974
0.33 (0.74) 0.43 (0.95)
5.9 (12.9) 6.3 (13.9)
- 0.64 (1.42)
36.5 (80.4)
2.3 (5) - 1971 35.5 (77.9)
145.1 (319.7) 171.1 (376.8)
1674 (3682)
10,074 (22,190)- - -
494 (1087)
36.8 (81.0)
24.9 (54.9) -
1967
58.1 (128.0)
235.5 (518.6) 254 (558)
205.6 (453)
508.5 (1120)
1.82 (4)
216 (477)
352.9 (777.4)
476 (1047)
378.9 (834.5)
1975
-
-
-
-
-
-
1202 (2645)
-
_
-
155 (341)
-
-
-
-
-
-
—
(Continued)
-------
TABLE E-ll. (Continued)
*>
o
Compound
Number (a) Earlier Years
89 29.1 (64.2) -
1969
94
101
104
112
111G Cresylic
116
122
123 325.5 (716.9) -
1968
124
125
133
134
135
142
143
144
148
150
154
Total Production, millions of kg (millions of pounds)
1972 1973
180.5 (397.5)
115 (252.8)
-
11.2 (24.7
35.9 (79.0)
1210 (2665)
965 (2123)
— ~
289.7 (638.2)
965 (2123)
63.4 (139.7) 30 (66)
28.5 (62.7)
222 (488.8)
48.3 (106.2)
5 (11.1)
122.0 (268.7)
11.5 (25.3)
12.6 (27.8)
6.2 (13.7)
1974
-
-
134.0 (295.2)
63.6 (140)
-
-
1325 (2910)
1063.7 (2343)
«•
-
1068 (2352)
-
-
233.8 (515)
50.4 (111)
-
140.5 (329.1)
-
-
•H
1975
-
-
-
-
-
-
895 (1970)
-
-
-
805 (1773)
-
-
-
-
-
-
-
-
-
(Continued)
-------
TABLE E-ll. (Continued)
Compound
Number'3'
254
256
257
259
265
268
269
275
276
279
284
285
286
288
289
292
293
295
299
Total Production, millions of kg (millions of pounds)
Earlier Years 1972
55.4 (112) -
1967
-
151.8 (334.3) -
1971
-
-
30.9 (68) - 1968
-
-
-
-
-
-
-
-
-
-
-
-
10.8 (23.8) -
1955
1973
22.4 (49.3)
-
-
833 (1835)
128 (282)
-
321 (706)
3210 (7064.4)
16.8 (37.0)
247 (544.1)
236 (520.2)
-
246 (540.7)
15.9 (35)
70.3 (154.8)
23.8 (52.5)
228 (501.8)
164 (360)
"
1974
-
53.6 (118)
-
869.1 (1914.4)
132 (290)
-
-
3126 (6878)
24.9 (54.7)
207.3 (456.7)
264.1 (581.7)
-
230 (506)
-
94 (207)
26 (57)
-
-
1975
-
-
-
-
-
-
-
-
-
-
-
91 (200)
-
-
-
-
-
-
(Continued)
-------
TABLE E-ll. (Continued)
Compound
Number ^a'
302
316
322
327
331
334G
337
338
343
344
346
347
349
350
351
353
356
357
Total Production, millions of kg (millions of pounds)
Earlier Years
-
-
-
-
-
29.1 (64) -
1971
-
1972
140.
49
46.8
321
1019
-
330.6
1973
1 (308.7)
(108)
(103.2)
(706)
(2241)
-
(728.2)
465 (1023)
104.4 (230 -
1967
-
-
21,802 (48,022) -
1971
-
-
-
-
-
3.4 (7.4) -
1968
-
25.8
38.8
-
27.4
42.1
7.6 (16.7) 0.20
4493
797
-
-
(56.9)
(85.5)
-
(60.4)
(92.6)
(0.44)
(9884)
(1753)
1974
-
-
57 (125)
334 (734)
1045 (2298)
-
394 (867)
444 (977)
84 (184)
44 (97)
-
-
40 (87)
44 (2fi)
1.6 (3.6)
4761 (10,475)
798 (1756)
-
1975
—
-
45.2 (99.6)
306 (674)
783 (1722)
-
-
322 (709)
-
-
-
-
—
-
-
3454 (7598)
692 (1523)
-
(Continued)
-------
TABLE E-ll. (Continued)
Compound Total Production, millions of kg (millions of pounds)
Number (a> Earlier Years 1972
358 11.8 (26) -
1970
360 6.2 (13.6) -
1969
362
363 29.5 (64.9) -
1970
365
368
374 (TPA)
374 (DMT)
377
382
390
391 170.1 (374.6) -
1971
392
393
396
397
398
401
1973
-
18.9 (41.5)
5.4 (11.8)
31.1 (68.5)
17.5 (38.6)
2716 (5975)
—
160.4 (353.3)
87.6 (193)
13 (28)
-
205 (451.7)
152 (334)
44.8 (98.5)
-
51.3 (113.1)
13.1 (28.9)
1974
-
20 (44)
-
-
-
2708 (5956)
1936 (4260)
1483 (3262)
211 (464)
-
-
193.0 (425.1)
176 (388)
156.2 (344)
49 (108)
13 (29)
50 (110)
-
1975
-
-
-
-
-
1999 (4398)
2114 (4650)
-
-
-
—
-
-
-
-
-
-
(Continued)
-------
TABLE E-ll. (Continued)
Compound Total Production, millions of kg (millions of pounds)
Number ^ Earlier Years 1972
402
403
404
£ 405
407G
408
409
1973
3305 (7271)
683 (1503)
2432 (5351)
-
-
485 (1068)
1057 (2326)
1974
3447 (7583)
638 (1403)
2555 (5621)
77.2 (170)
2627 (5780)
480 (1056)
1230 (2707)
1975
3359 (7390)
516 (1136)
1907 (4196)
-
2309 (5080)
308 (679)
1102 (2425)
(a) Item number of compound in Industrial Organic Chemicals table.
-------
TABLE E-12. TOTAL PRODUCTION - INDUSTRIAL ORGANIC CHEMICALS
[LISTED ACCORDING TO INCREASING PRODUCTION FOR 1973]
Total Production,
MM kg (MM pounds)
0.20
0.33
0.9
1.0
1.8
1.82
2.8
2.9
5
5
5
6
7
7
8
10
11
11
12
13
15
15
16
17
18
18
22
23
.35
.45
.9
.2
.1
.4
.1
.9
.2
.5
.6
.1
.7
.9
.8
.5
.2
.9
.4
.8
(0.44)
(0.74)
(2.0)
(2.2)
(4.0)
(4.0)
(6.1)
(6.5)
(11.
(12.
(12.
(13.
(15.
(16.
(17.
(23.
(24.
(25.
(27.
(28.
(34.
(35)
(37.
(38.
(40)
(41.
(49.
(52.
8)
0)
9)
7)
7)
2)
9)
9)
7)
3)
8)
9)
7)
0)
6)
5)
3)
5)
Compound
Number (a)
351
47
33
12
6
73
206
195
362
24
51
154
161
176
244
242
112
148
150
401
178
288
276
365
15
360
254
292
Total Production,
MM kg (MM pounds)
30
31.1
32.8
36.8
38.8
39.1
40.2
42.1
44
45
45
46
48
49
51
55
58
59
60
62
70
79
81
86
87
.8
.7
.7
.8
.3
.3
.2
.1
.7
.2
.4
.3
.2
.7
.5
.6
(66)
(68.5)
(72.4)
(81.0)
(85.5)
(86.2)
(88.4)
(92.6)
(98.5)
(100.
(100.
(103.
(106.
(108)
(113.
(121.
(128)
(131.
(132.
(137.
(154.
(174.
(180)
(190.
(193)
94.4 (208)
(synthetic
100
.5
(221.
7)
7)
2)
2)
1)
5)
6)
8)
8)
8)
3)
3)
only)
5)
Compound
Number(a)
133
363
222
67
346
216
188
350
396
239
241
322
142
316
398
160
70
16
248
211
289
253
185
213
382
232
189
(Continued)
647
-------
TABLE E-12. (Continued)
Total Production,
MM kg (MM pounds)
24.1 (53.1)
24.2 (53.3)
24.3 (53.5)
25.8 (56.9)
26.1 (57.5)
27.4 (60.4)
28.5 (62.7)
150.3 (331.1)
152 (334)
160.4 (353.3)
180.5 (397.5)
182.5 (402.3)
205 (451.7)
205.6 (453)
207.8 (457.6)
216 (477)
222 (488.8)
228 (501.8)
235.5 (518.6)
236 (520.2)
246 (540.7)
247 (544.1)
272.6 (600.5)
289.7 (638.2)
299.7 (660.1)
321 (706)
330.6 (728.2)
352.9 (777.4)
378.9 (834.5)
465 (1023)
Compound
Number'3'
229
181
230
344
111G
349
134
203
393
377
94
223
392
71
30
80
135
293
62
284
286
279
295
124
196
327
337
84
88
338
Total Production,
MM kg (MM pounds)
115
122.0
125.1
127.8
138.1
140.1
145.1
614.8
683
711
758.2
797
833
890
904
965
965
1019
1057
1104
1210
1485
1890
2432
2580
2716
2918
3210
3305
4210
(252.8)
(268.7)
(275.5)
(281.8)
(304.3)
(308.7)
(319.7)
(1354.2)
(1503)
(1567)
(1670)
(1753)
(1835)
(1961.8)
(1989)
(2123)
(2123)
(2241)
(2326)
(2429)
(2665)
(3277.6)
(4167)
(5351)
(5688)
(5975)
(6424.1)
(7064.4)
(7271)
(9292.7)
Compound
Number'3'
101
144
191
265
243
302
57
17
403
18
8
356
259
187
9
122
125
331
409
7
116
205
221
404
193
368
227
275
402
204
(Continued)
648
-------
TABLE E-12. (Continued)
Total Production,
MM kg (MM pounds)
476
485
508.5
(1047)
(1068)
(1120)
Compound
Number (a)
86
408
72
Total Production, Compound
MM kg (MM pounds) Number'3)
4493 (9884) 353
5130 (11,300) 36
(a) Item number of compound in Industrial Organic Chemicals table.
649
-------
TABLE E-13. INDUSTRIAL ORGANIC CHEMICAL HUMAN AND ANIMAL TOXICITY AND
CARCINOGEN DATA ADDED DURING 1979 REVISION^)
Item
No.
Human Toxicity
Animal Toxicity
Carcinogen
2
6
14
17
39
44
45
48
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
3a)7
This value is incorrect,
data should be 500 mg/kg
LDLo:5 mg/kg, orl
18
19 LDLo:50 mg/kg, orl
20 LCLo:3000 ppm, ihl
22 LDLo:500 mg/kg, orl
24 TCLo:5000 mg/m3/30M, ihl
26 LDLo:500 mg/kg, orl
30 LDLo:350 mg/kg, orl
37 LDLo:500 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo;40 mg/kg, orl
LDLo:500 mg/kg,
orl-dog
LCLo:8 ppm/4H
ihl-rat
LD50:275 mg/kg,
ipr-rat
LC50:165 ppm/4H
ihl-rat
LD50:64 mg/kg,
ivn-rbt
LC50:250 ppm
ihl-rat
LD50:9 mg/kg,
ipr-mus
LD50.-28 mg/kg,
orl-mus
Human carcinogen
TCLo:80 ppm/GH/52W
TFXtNEO, ihl-rat
TDLo:1700 mg/kg/37WC
TFXrNEO, orl-rat
Human leukemogen
TCLo:2100 mg/m3/44I
TFX:CAR, ihl-man
(Continued)
650
-------
TABLE E-13. (Continued)
Item
No.
Human Toxicity
Animal Toxicity
Carcinogen
50 TCLo:2 ppm/lM, ihl
51 LDLo:500 mg/kg, orl
53 LD50:500 mg/kg, orl
54
65 LDLo:500 mg/kg, orl
70 LDLo:500 mg/kg, orl
74
84 LDLo:14 mg/kg, orl
86 LDLo:43 mg/kg, orl
88 LDLo:500 mg/kg, orl
89 LDLo:50 mg/kg, orl
90
92
101 LDLo:40 mg/kg, orl
104
105
TCLo:0.012 mg/m3, ihl
(ortho)
111 LDLo:50 mg/kg, orl
115
119 TCLoilO mg/m3, ihl
LC50:150 ppm/2H
ihl-rat
LD50:225 mg/kg,
orl-dog
TCLo:300 ppm/(6-15D
preg)
TFX:TER, ihl-rat
LDLo:125 mg/kg,
ivn-dog
TDLo:71 gm/kg/78W
TFX:CAR, orl-mus
TDLo:100 mg/kg
TFX:NEO, scu-mus
LDLo:222 mg/kg,
skn-cat
LD50:223 mg/kg,
skn-cat
TCLo:100 ppm/7H/ TDLo:70 gm/kg/78WI
(6-15D preg)
TFX:TER, ihl-rat
LD50:135 mg/kg
orl-mus (ortho)
TFX:NEO, orl-rat
TDLo:6 gm/kg/15WI,
TFX:NEO
LD50:100 mg/kg,
ipr-rat
(Continued)
651
-------
TABLE E-13. (Continued)
Item
No.
Human Toxicity
Animal Toxicity
Carcinogen
120
122
126
127
128
129
133
141
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
TCLo:100 ppm, ihl
TCLo:100 ppm, ihl
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
144 LDLo:1000 mg/kg, orl
148 LDLo:500 mg/kg, orl
150 LDLo:500 mg/kg, orl
151 LDLo:500 mg/kg, orl
161 LDLo:50 mg/kg, orl
163 LDLo:500 mg/kg, orl
164 LCLo:97 ppm/lOM, ihl
167 TDLo:4 mg/kg/2DI
TFXrBLD, skn
169
176 LDLo:500 mg/kg, orl
178 LDLo:500 mg/kg, orl
185 LDLo:50 mg/kg, orl
187 TDLo:1.43 mg/kg, orl
189 TCLo:400 ppm-IRR, ihl
191 TCLo:50 ppm-IRR, ihl
LD50:135 mg/kg,
scu-mus
LCLo:130 mg/m3
ihl-mus
LDLo:27 mg/kg,
orl-cat
LD50:29 mg/kg,
orl-cat
LD50:300 mg/kg,
orl-gpg
TDLo:7500 mg/kg
(9D preg)
TFX:TER
TDLo:55 gm/kg/82WI
TFX.'NEO, orl-rat
TDLo:27 gm/kg/2YI
TFXrNEO, scu-rat
TDLo:12 gm/kg/52WI
TFX:CAR, skn-mus
(Continued)
652
-------
TABLE E-13. (Continued)
Item
No.
193
200
Human Toxicity
TCLo:100 ppm/4H IRR, ihl
Animal Toxicity
LDLo:500 mg/kg,
Carcinogen
—
201 LDLo:50 mg/kg, orl
LCLo:300 ppm/2H, ihl
203 LDLo:50 mg/kg, orl
204 LDLo:500 mg/kg, orl
ipr-mus
LD52:385 mg/m3,
ihl-mus
Experimental
mutagen and
teratogen
3)658
TDLo:400 mg/kg/10WI
TFXrCAR, orl-rat
TDLo:18 gm/kg/42WI
TFX:CAR, orl-mus
Experimental carcinogen
3)658
206
211
213
217
219
222
227
238
241
242
243
244
245
248
255
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
LDLo:420 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:0.57 mg/kg, orl
LDLo:29 mg/kg, orl
LDLo:50 mg/kg, orl
LDLo:500 mg/kg, orl
TCLo:25 ppm-IRR, ihl
—
—
—
—
—
—
—
—
LD50:200 mg/kg,
scu-rat
—
—
—
TDLo:27 gm/kg/I
TFX:CAR, orl-rat
TDLo:3.8 gm/kg/I
TFX:CAR, scu-rat
TDLo:29 gm/kg/I
TFX:CAR, orl-rat
TDLo:9 gm/kg/I
TFXrCAR, scu-rat
—
(Continued)
653
-------
TABLE E-13. (Continued
Item
No.
258
267
280
281
282
284
285
286
287
288
289
290
295
298
299
302
307
310
320
327
335
336
337
340
342
246
Human Toxicity
TDLo:200 ppm-EYE, ihl
TCLo:25 ppm-IRR, ihl
LDLo:500 mg/kg, orl
TCLo:500 ppm-IRR, ihl
—
LDLo:500 mg/kg, orl
TDLo:8.42 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:500 mg/kg, orl
TCLo:50 ppm-IRR, ihl
LDLo:500 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
LDLo:50 mg/kg, orl
LDLo:50 mg/kg, orl
LDLo:5 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:500 mg/kg, orl
TDLo:14 mg/kg-PSY, orl
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
LDLo:50 mg/kg, orl
LC50:3200 mg/m3, ihl
LDLo:50 mg/kg, orl
LDLo:5000 mg/kg, orl
LDLo:500 mg/kg, orl
Animal Toxicity Carcinogen
—
—
—
—
LD50:200 mg/kg,
ipr-mus
—
—
TCLo:1000 ppm/(6-
15D preg)
TFX:TER, ihl-rat
—
—
—
—
—
—
—
—
—
—
—
—
—
::
TDLo:1.7 gm/kg/145DI
TFX:CAR, scu-rat
TDLo:101 gm/kg/461DI
TFX:NEO, orl-rat
(plus 2 other data sets)
—
—
(Continued)
654
-------
TABLE E-13. (Continued)
Item
No.
Human Toxicity
Animal Toxicity
Carcinogen
350 LDLo:500 mg/kg, orl
355 LDLo:50 mg/kg, orl
358 LDLo:29 mg/kg, orl
360 LDLo:50 mg/kg, orl
368 LDLo:500 mg/kg, orl
375 LDLo:50 mg/kg, orl
380
382 LDLo:50 mg/kg, orl
388 LDLo:50 mg/kg, orl
391 LDLo:50 mg/kg, orl
392 LDLo:50 mg/kg, orl
396 LDLo:5000 mg/kg, orl
398 LDLo:5000 mg/kg, orl
405 TCLo:25 ppm-SYS, ihl
410 LDLo:50 mg/kg, orl
415 LDLo:50 mg/kg, orl
1ADD TCLo:2 ppm/lM-IRR
3ADD LDLo:50 mg/kg, orl
4ADD
6ADD LDLo:500 mg/kg, orl
11ADD
14ADD
23ADD
33ADD LDLo:5 mg/kg, orl
38ADD LDLo:5 mg/kg, orl
40ADD LDLo:500 mg/kg, orl
LDLo:80 mg/kg,
ivn-rbt
TDLo:4800 mg/kg/12WI
TFXiNEO, skn-mus
Experimental carcinogen
3)1088
TDLo:4100 mg/kg/12WI
TFX:NEO
Experimental carcinogen
3)453
Polycaprolactam
TDLo:5 film discs/rat
TFX:NEO, imp-rat
Experimental carcinogen
(Continued)
655
-------
TABLE E-13. (Continued)
Item
No.
Human Toxicity
Animal Toxicity
Carcinogen
42ADD LDLo:500 mg/kg, orl
45ADD
48ADD LDLo:500 mg/kg, orl
54ADD LDLo:50 mg/kg, orl
55ADD
59ADD TCLo:75 ppm-IRR, ihl
61 ADD LDLo:50 mg/kg, orl
64ADD LDLo:5000 mg/kg, orl
66ADD LDLo:0.071 mg/kg, orl
2)609
65ADD
68ADD LDLo:50 mg/kg, orl
70ADD
77ADD LDLo:500 mg/kg, orl
80ADD LDLo:50 mg/kg, orl
81ADD TCLo:0.02 ppm/2Y/PUL
82ADD LDLo:500 mg/kg/orl
83ADD LDLo:500 mg/kg, orl
84ADD LDLo:1000 mg/kg, orl
88ADD LDLo:50 mg/kg, orl
90ADD LDLo:50 mg/kg, orl
TDLo:500 mg/kg (7-
11D preg)
TFX:TER, orl-mus
TDLo:500 mg/kg
(D preg)
TFX:TER, scu-rat
LD50:320 mg/kg,
skn-rbt
TCLo:400 ppb/35WI
TFX:CAR, ihl-rat
TDLo:410 mg/kg/26WC
TFX:CAR, orl-mus
TDLo:38 gm/kg/63WI
TFX:NEO, skn-mus
TDLo:330 mg/kg/82W
TFX:NEO, scu-mus
TDLo:29 gm/kg/78WI
TFX:CAR
(a) All new human toxicity data are included, with much of the data from
reference 39, as cited in reference 2, 1977 edition. Animal data includes
all new teratogenic or mutagenic data, all new LD50 or LDLo data _< 500 mg/
kg and all new LC50 or LCLo data £ 1000 ppm or 200 mg/m3, except new LD50:
orl-rat data. These are in Table E-6 only. Carcinogenic data includes
all new entries.
656
-------
APPENDIX F
EPA PRIORITY LISTS
TABLE F-l. EFFLUENT GUIDELINES PRIORITY
LIST (IOC - Phase l)
-------
TABLE F-2. EFFLUENT GUIDELINES PRIORITY
LIST (IOC - Phase 2)^a)
IOC
Compound Item Number(b)
Acrylonitrile 17
Sec-Butyl alcohol 71
Chlorinated methanes 279, 284, 101, 86
Cresol, synthetic 111C
Citric acid
Cumene 116
Dyes and dye intermediates ODP
Hexamethylene diamine 43ADD
Hexamethylene tetramine 241
Isobutylene 64
Isopropanol 259
Maleic anhydride 265
Methyl ethyl ketone 286
Monosodium glutamate
Pentaerythritol 322
Perchloroethylene 327
Propylene oxide 356
Plasticizers
p-Xylene 409
(a) Taken from Reference 18.
(b) 43ADD found in Table A-2, IOC Addendum.
658
-------
TABLE F-3. WATER QUALITY PLANNING AND STANDARDS CONSENT DECREE LIST
(a)
Compound
Appendix Item Number
IOC DP-I
Ui
VO
Acenaphthane
Acrolein
Acrylonitrile
Benzene
Benzidine
Carbon tetrachloride
Chlorinated benzenes
Chlorobenzene
Trichlorobenzenes (isomers)
(1,2,4-Trichlorobenzene)
Chlorinated ethanes
1,2-Dichloroethane
1,1,1-Trichloroethane
Hexachloroethane
Chloroalkyl ethers
Chloromethyl ether (Dichloromethyl ether)
Chloroethyl ether (Dichloroethyl ether)
Mixed ethers
Chlorinated naphthalene
1-Chloronaphthalene
2-Chloronaphthalene
Chlorinated, phenols
Trichlorophenols (isomers)
Chlorinated cresols (isomers)
Chloroform
2-Chlorophenol(b)
Cyanides
Hydrogen cyanide
Acetone cyanohydrin (2-Methyl lactonitrile)
1
14
17
39
5ADD
86
(General class - other than dichlorobenzenes)
94DP
390G
390
(General class - specified compounds follow)
204
82ADD
238
(General class - specific compounds follow)
137
(General class - specific compounds follow)
102
103
%
(General class - other than those listed elsewhere,
includes trichlorophenols and chlorinated cresols)
8 3 ADD
101
106DP
243
10
(Continued)
-------
TABLE F-3. (Continued)
Compound
Appendix Item Number(b)
IOC DP-I
Dichlorobenzenes (General class)
2,3-Dichlorobenzene
1,3-Dichlorobenzene
1,4-Dichlorobenzene
Dichlorobenzidine
Dichloroethylenes (General class)
l,l-Dichloroethylene(c)
1,2-Dichloroethylene
2,4-Dichlorophenol
Dichloropropane (General class)
1,2-Dichloropropane
Dichloropropene (General class)
1,2-Dichloropropene
2,4-Dimethylphenol(d)
Dinitrotoluene (Isomers below)
2,3-Dinitrotoluene
2,4-Dinitrotoluene
2,5-Dinitrotoluene
2,6-Dinitrotoluene
D iphenyIhyd ra z ine
Ethyl benzene
Fluoranthene
Haloethers
Chlorophenylphenyl ether
Bromophenylphenyl ether
Bis(dichloroisopropyl) ether
Polychlorinated diphenyl ether (isomers)
Halomethanes
Methylene chloride
Methyl chloride
133G
133DP
25ADD 281
134DP
434
405
136
27ADD
355
140
410
172G
172
173
174
175
35ADD
193
(Genral class - other than those listed elsewhere)
(General class - other than those listed elsewhere)
284
279
(Continued)
-------
TABLE F-3. (Continued)
Compound
Appendix Item Number'"'
IOC DP-I
Methyl bromide
Bromoform
Dichlorobromomethane
Trichlorofluoromethane
Dichlorodifluoromethane
Hexachlorobutadiene
Hexachlorocyclohexane
Hexachlorocyclopentadiene
Naphthalene
Nitrobenzene
2,4-Dinitrophenol
Pentachlorophenol
Phenol
Tetrachloroethylene
Toluene
Trichloroethylene
Vinyl chloride
61 ADD
393
255
295DP
(General - specific compounds follow)
33ADD
331DP
30
392
404
(a) Inorganics and organic insecticides and herbicides deleted from published decree as not pertinent.
The chemicals listed are to be covered by the Effluent Guidelines Standards for Best Available
Technology Economically Achievable by June 30, 1983.
(b) ADD refers to compounds in Table A-3, IOC Addendum, DP-I to compounds in Table B-2.
(c) Table B-l.
-------
TABLE F-4. POTENTIALLY SIGNIFICANT AIR TOXICANTS
FROM THE OFFICE OF AIR QUALITY
PLANNING AND STANDARDS (AQPS)
Compound
IOC Number
Acetaldehyde
Acetonitrile
Acrolein
Acrylonitrile
Allyl chloride
Aniline
Benzene
Carbon tetrachloride
Chloroform
Chloroprene
Di(2-ethyl hexyl phthalate)
Dimethylamine
Dioxane
Ethylene dibromide
Ethylene oxide
Formaldehyde
Hydrogen cyanide
Maleic anhydride
Nitrobenzene
Perchloroethylene
Trichloroethylene
Vinylidine chloride
3
11
14
17DP(a)
20
30DP
39
86
101
18ADD
-------
TABLE F-5. THIS STUDY "PRIORITY" LIST IOC DISTRIBUTION
ON EPA PRIORITY LISTS(a»b)
IOC
Item
No.
1
3
10
14
16
17
20
30
39
70
71
86
101
111
113
133
134
135
137
140
160
173
175
176
203
204
205
221
227
241
243
259
265
275
284
295
302
327
331
Effluent
Guidelines
Priority
List - Phase 1
(Table F-l)
«••—
X
—
—
X
—
—
3X
2X
X
—
—
—
—
X
—
—
—
—
—
—
—
—
—
—
2X
2X
—
3X
—
—
—
—
3X
—
—
—
—
4X
Effluent
Guidelines
Priority
List - Phase 2
(Table F-2)
—
—
—
—
3X
—
—
—
—
X
3X
2X
X
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
2X
—
2X
3X
—
X
—
—
X
—
WQPS
Consent
Decree
List
(Table F-3)
X
—
2X
—
—
3X
—
—
2X
—
—
3X
2X
—
—
2X
2X
--
3X
2X
—
X
X
—
—
—
—
—
—
—
2X
—
—
—
X
2X
2X
__
4X
OAQPS
Priority
List
(Table F-4)
^«v
X
—
2X
—
3X
2X
3X
2X
—
—
3X
2X
—
—
—
—
—
—
—
X
—
—
3X
2X
—
—
3X
3X
—
2X
—
2X
—
—
—
—
__
—
(Continued)
663
-------
TABLE F-5. (Continued)
Effluent Effluent WQPS
Guidelines Guidelines Consent OAQPS
IOC Priority Priority Decree Priority
Item List - Phase 1 List - Phase 2 List List
No. (Table F-l) (Table F-2) (Table F-3) (Table F-4)
356 — 2X
368 2X
377 X
403 X
404 -- -- 2X
405 — -- 2X
410 — — X
(a) Eight (8) "priority" lists from the present study are included
(Tables E-4 through E-10).
(b) X means commonality of entrants on one table from the group
Table E-4 through Table E-10, 2X and 3X indicate occurrence
on two or three of these tables.
664
-------
TABLE F-6. LIST OF POTENTIALLY HAZARDOUS WASTE MATERIALS(a)
IOC Item No.
3
7
8DP
9DP
10
11
1ADD
13
Acridine
14
16
17DP
19
20
24 (Banana Oil)
25 (Fusel Oil)
30
Anthracenes
39
42 ADD
41DP
44DP
54DP
60
61
62DP
64
67
70
73DP
Butyl mercaptan
78DP
80
84
86
337
Chloral hydrate
Chloroacetophenone
94DP
101
User's
SIC No.(b)
__
20,38
20,26,36
38
—
__
20 20
34 34
—
19
22,26,31
22,30
19
—
20,22,39
22,38
30,38
—
—
—
__
38
—
30
29
—
—
22,26
30
—
—
—
—
—
—
—
—
29
—
—
Production
MM, Ibs
1,652
1,770
1,675
1,589
970
150
<10
468
<10
<10
150
1,037
10
10
10
64
372
100
8,000
800
10
55
88
3,054
2,160
404
1,630
127
63
11
10
10
10
1,640
935
447
10
10
700
239
(Continued)
665
-------
TABLE F-6. (Continued)
IOC Item No.
18ADD
111G
114
116
128
122
123DP
124DP
126DP
128
Dibutyl phthalate
133DP
134DP
137
284
355
140
142DP
143DP
222
176
28ADD
158
Diisobutylketone
160DP
181
3 7 ADD
185
186
187DP
188DP
189
191
192DP
193
196DP
199
203DP
Ethylene cyanohydrin
202
User's Production
SIC No.(b) MM, Ibs
154
20,33 245
20 <10
1,500
<10
280
716
704
30 72
162
29
75
72
—
418
86
— —
92
29,30 7
102
— —
—
32
—
74
45
533
20 120
—
20 320
22,29 265
159
22,26,31 167
20 16
4,700
600
15,600
29
—
65
(Continued)
666
-------
TABLE F-6. (Continued)
IOC Item No.
Dibromoethane
204
205DP
213
212
221DP
2 8 ADD
223
Ethyl mercaptan
286
Ethyl phthalate
2-Ethyl-3-propylacrolein
227DP
229DP
40 ADD
Furfural alcohol
Heptane
4 3 ADD
Hexane
243
244DP
249
248DP
255
257
259
258
260DP
5 3 ADD
267
275
273
5 9 ADD
276DP
61 ADD
279
Methyl chloro formate
287
289
Methyl mercaptan
User's
SIC No.(b'
—
—
—
—
—
—
22,26,34
—
—
—
—
—
20,22,39,73
22,31
—
__
—
34
—
33,34
34
34
—
—
30
—
—
—
22
—
29
—
31
30
—
30
—
26
—
29
Production
MM, Ibs
_ _
6,700
2,400
—
—
3,671
1.5
440
—
—
—
—
4,312 (37%)
40
380
22
244
—
232
410
12
—
—
—
300
2,000
44
20
12
—
9,245
9
—
120 (30%)
21
432
—
—
—
—
(Continued)
667
-------
TABLE F-6. (Continued)
IOC Item No.
64ADD
277
294DP
295DP
96 and 980DP-l(°)
302DP
278, 279, and 2800DP-I(c)
306
307
309
310
311
313
65ADD
67ADD
Pentachloro phenol
323
327
331DP
374DP
347
348
349
n-Propylacetate
350
351
353
293
356
355
357DP
48
360DP
365DP
Sodium oxalate
368
375DP
377
81 ADD
Tetramethyllead
User's
SIC No.(b>
29
—
30,34
31,34
___
30
—
29
34
—
—
19,34
22,31
—
22,24,26
38
22
—
—
29
30,32
—
20
—
29
—
—
—
20
30
34
30
—
—
26
—
—
—
—
Production
MM, Ibs
430
—
21
700
10
515
100
—
—
50
—
—
18
23
—
47
—
706
1,680
760
7,200
—
40
21
68
0.2
7,240
450
1,121
—
7
—
44
—
—
4,400
—
371
—
76
(Continued)
668
-------
TABLE F-6. (Continued)
IOC Item No.
82ADD
387
390DP
391
392
396
397
399
88ADD
401
85ADD
403
404
407DP
User's
SIC No.(b)
29
22
—
22,33,34
—
32
—
29
—
—
29,35
—
30,44
—
Production
MM, Ibs
—
9
15
340
239
77
—
80
—
20
48
799
4,040
~ —
(a) Reference 18.
(b) End use patterns for the chemical, classified by standard
industrial classification numbers, as shown below.
(c) Table B-2, organic dyes and pigments - intermediates.
(d) Table B-l. organic dyes and pigments - other materials.
669
-------
TABLE F-7. SPILLS LIST OF POTENTIALLY HAZARDOUS SUBSTANCES(
Compound
Acetaldehyde
Acetic acid
Acetic anhydride
Acetone cyanohydrin
Acetyl bromide
Acetyl chloride
Acrolein
Acrylonitrile
Adiponitrile
Allyl alcohol
Allyl chloride
Benzene
Benzoic acid
Benzonitrile
Benzoyl chloride
Benzyl chloride
Butyl acetate
Butylamine
Butyric acid
Carbon disulfide
Chlorobenzene
Chloroform
Chlorosulfonic acid
Cresol
EPA Toxicological
Criteria^)
1
1
1
2
1
1
1,2
1
1
1
1
1
1
1,3
1
1
1,2
1
1
1
1
1
1
1
Appendix Table
Item Numbers (°)
IOC DP-R DP-I
3
7
8
10
—
1ADD
14
17
2ADD
19
20
39
44DP
46
50DP
54DP
65 (d)
66 --
81
84
94DP
101
8ADD
lll(D II
H2(J)
11300
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
(Continued)
670
-------
TABLE F-7. (Continued)
Compound
Hydrogen cyanide
Cyclohexane
2, 6-Dichlorobenzonitrile
Diethylamine
Dimethylamine
Dinitrobenzene
Dinitrophenol
Dodecylbenzenesulfonic acid
Ethyl benzene
Ethylenediamine
Ethylenediaminotetraacetic acid
(EDTA)
Formaldehyde
Formic acid
Fumaric acid
Furfural
Isoprene
Maleic acid
Maleic anhydride
Methyl mercaptan
Methyl methacrylate
Monoethylamine (ethylamine)
Monomethylamine
Naphthalene
Naphthenic acid
Nitrobenzene
EPA Toxicological
Criteria(b)
1,2
1
1
1
1
1
1,2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Appendix Table
Item Numbers'0'
IOC
243
122
—
143DP
—
167G_
16800
—
—
193
202
—
227DP
229DP
230
—
257
264
265
—
6 4 ADD
192DP
276DP
295DP
—
303G
303(J)
304 00
DP-R DP- I
—
—
—
—
11
291
—
—
—
—
—
— —
—
—
—
—
—
—
—
23
—
—
—
—
—
—
(Continued)
671
-------
TABLE E-7. (Continued)
Compound
Nitrophenol
Paraformaldehyde (Paraform)
Pentachlorophenol
Phenol
Phosgene
Polychlorinated biphenyls (PCB)
Propionic acid
Propionic anhydride
Propyl alcohol
Quinoline
Resorcinol
Styrene
Tetraethyl lead
Tetraethylpyrophosphate
Toluene
Trichlorophenol
Triethylamine
Trimethylamine
Vinyl acetate
Xylene
Xylenol
EPA Toxico logical
Criteria^
1
1
1
1
1
1
1
1
1
1
1
1
1
1,2
1
1
1
1
1
1
1
Appendix Table
Item Numbers'0'
IOC DP-R DP-I
308G
308(J)
309 (k>
67ADD
—
331DP
337
—
349
—
350
—
358DP
368
377
—
30
84ADD
397
401
403
407DP
410G
410(D
41! On)
412 (n)
413(o)
414
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
—
See footnotes on following page.
672
-------
Footnotes for Table F-7.
(a) Reference 6.
(b) Toxicological criteria.
1 = aquatic animal toxicity
2 = oral mammalian toxicity
3 = dermal mammalian toxicity.
(c) Item numbers in master Tables A-l, B-l, and B-2.
IOC = Industrial Organic Chemicals
DP-R = Dye and Pigment Raw Material
DP-I = Dye and Pigment Intermediate
G = commercial isomer mixture.
(d) 1j-
(f) sec-
(g) tert-
(h) Cresylic acid
(i) m-
(j) o-
(k) p-
U) 2,4-
(m) 2,5-
(n) 3,4-
(o) 3,5-
(p) 2,6-
673
-------
APPENDIX G
ORGANIC DYES AND PIGMENTS - EXTRACTION TABLES BASED ON
TOXICITY AND PRODUCTION VOLUME DATA IN TABLES B-l THROUGH B-2
TABLE G-l. U. S. OCCUPATIONAL STANDARD (USOS) FOR CONCENTRATIONS IN AIR -
ORGANIC DYES AND PIGMENTS
[Listed alaphabetically according to compound]
Compound (a)
DP-RO 3
DP-RO 9
DP-RO 11
DP-RO 15
DP-RO 20
DP-RO 23
DP-RO 25
DP-RO 30
DP-RI 5
DP-RI 6
DP-RI 7
DP-RI 7
DP-RI 16
DP-RI 18
DP-RI 19
DP-RI 21
DP-RI 22
DP-RI 23
DP-RI 26
DP-RI 27
DP-RI 28
Concentration ^ '
0.5 mg/m3
50 ppm
10 ppm
1 ppm
25 ppm
0 . 5 ppm
1 mg/m3
100 ppm
10.2 mg/m3
0.5 mg/m3
806 yg/m3
0.5 mg/m3
1 mg/m3
5 ppm
0 . 1 ppm
258 yg/m3
230 yg/m3
10 mg/m3
0.05 mg/m3
3 mg/m3
1 mg/m3
Compound (a/
DP-RI 29
DP-RI 33
DP-RI 34
DP-RI 37
DP-RI 45
DP-RI 49
DP-RI 50
DP-RI 54
DP-I 83
DP-I 93
DP-I 98
DP-I 104
DP-I 105
DP-I 280
DP-I 291
DP-I 674
DP-I 683
DP-I 743
DP-I 744
DP-I 745
Concentration (b)
1 mg/m3
1 mg/m3
0.5 ppm
2 mg/m3
3.2 mg/m3
1 ppm
1 PPm
1 mg/m-*
5 ppm (skn) 'c'
2 ppm (skn)
1 ppm (skn)
0.1 ppm (skn)
0. 1 ppm (skn)
1 mg/m3 (skn)
1 mg/m3 (skn)
100 yg/m3 (skn)
0.1 mg/m3
5 ppm
5 ppm
5 ppm
DP-D 447
ppm
(a) Item number of compound in Organic Dyes and Pigment table.
DP-RO: Dyes and Pigments - organic raw material;
DP-RI: Dyes and Pigments - inorganic raw material;
DP-I: Dyes and Pigments - intermediate;
DP-D: Dyes and Pigments - dye
(b) Time weighed average (TWA).
(c) (skn) indicates additional absorption through the skin is possible
even when the concentration is below the indicated standard.
674
-------
TABLE G-2. HUMAN TOXICITY DATA - ORGANIC DYES AND PIGMENTS
Compound
Number (a)
DP-RO 29
DP-RI 19
DP-RI 23
DP-RI 29
DP-RI 29
DP-RI 30
DP-RI 54
DP-I 44
DP-I 63
DP-I 76
DP-I 279
DP-I 482
DP-I 708
DP-D 447
LDLo TDLo TCLo
10 ppm
2000 mg/kg
400 mg/m3
800 yg/m3
350 yg/m3
25 ppm/30M
4800 mg/m3/30M
1000 mg/kg
— — 44 mg/m3
25 yg/m3
12 yg/m3
500 mg/kg
5100 yg/m3
40 mg/kg
TFX
CNS
—
UNS
MTH
PUL
IRR
PUL
CNS
BLD
EYE
EYE
SKN
IRR
—
Adm(b)
ihl
orl
ihl
ihl
ihl
ihl
ihl
orl
ihl
ihl
ihl
skn
ihl
ivn
(a) Item number of compound in Organic Dyes and Pigments table.
DP-RO: Dyes and Pigments - organic raw material;
DI-RI: Dyes and Pigments - inorganic raw material;
DI-I: Dyes and Pigments - intermediate;
DP-D: Dyes and Pigments - dye.
(b) Method of administration (see list of abbreviations and acronyms).
675
-------
TABLE G-3. CARCINOGENS AND SUSPECTED CARCINOGENS
ORGANIC DYES AND PIGMENTS
Compound (a)
DP-RO 10
DP-RO 15
DP-RO 27
DP-RO 29
DP-RI 8
DP-RI 27
DP-RI 28
DP-RI 54
DP-I 84
DP-I 130
DP-I 131
DP-I 225
DP-I 226
DP-I 429
DP-I 434
DP-I 441
DP-I 459
DP-I 480
DP-I 633
DP-I 634
DP-I 635
DP-I 637
DP-I 743
DP-I 744
DP-I 745
TDLo
280 mg/kg/35W
400 mg/kg/5WI
10 gm/kg/3WI
18 gm/kg/2YC
8 gm/kg/50W
350 mg/kg/43WI
15 mg/kg/6WI
17 mg/kg
7300 mg/kg/lY
90 gm/kg/90DC
2740 mg/kg/61WI
17 gm/kg/2YI
4 mg/kg
5300 mg/kg/35WC
26 gm/kg/50W
6.5 mg/kg/44WI
9000 mg/kg/30DI
37 gm/kg/61W
16 gm/kg/lYI
Bladder carcinogen - hmn
31 gm/kg/YI, 25 mg/kg
dl gm/kg/YI
31 gm/kg/YI
Recognized carcinogen - hmn
Recognized carcinogen - hmn
Recognized carcinogen - hmn
Recognized carcinogen - hmn
TFX
NEO
CAR
NEO
NEO
NEO
GAR
NEO
NEO
NEO
NEO
NEO
NEO
CAR
CAR
CAR
CAR
NEO
CAR
NEO
_
NEO
CAR
CAR
-
-
-
-
Adm-Animal(b)
scu-rat
ipr-mus
skn-mus
orl-rat
ivg-mus
ims-rat
scu-rat
par -ham
orl-rat
orl-rat
orl-rat
scu-rat
scu-rat
orl-rat
orl-rat
scu-rat
orl-rat
skn-mus
scu-rat
._
scu-mus
orl-rat
orl-rat
-
-
-
—
(Continued)
-------
TABLE G-3. (Continued)
Compound 'a'
DP-D 10
DP-D 14
Ditto
DP-D 30
DP-D 52
DP-D 61
DP-D 63
DP-D 126
DP-D 169
DP-D 177
DP-D 181
DP-D 316
DP-D 343
DP-D 559
DP-D 576
DP-D 577
DP-D 579
DP-D 580
DP-D 583
DP-D 608
DP-D 631
DP-D 648
DP-D 873
(a) Item number
DP-RO: Dyes
DP-RI: Dyes
DP-I: Dyes
DP-D: Dyes
TDLo
1600 mg/kg/2.3 YI
800 mg/kg/40D
11 gm/kg/12WC
158 gm/kg/56WC
56 gm/kg/52WC
6 gm/kg/52W
80 mg/kg
428 gm/kg/65WC
2750 mg/kg/28WI
172 gm/kg/26WC
524 gm/kg/74WC
825 mg/kg/65WI
512 mg/kg/58WI
40 gm/kg/87WC
6500 mg/kg/33WI
5925 mg/kg/48WI
600 mg/kg/43WC
17 gm/kg/2YI
1290 gm/kg/86WC
9400 mg/kg/2YI
270 gm/kg/30WI
7200 mg/kg/44WI
10 gm/kg/2YI
of compound in Organic Dyes and Pigments
and Pigments - organic raw material;
and Pigments - inorganic raw material;
and Pigments - intermediate;
and Pigments - dye.
TFX
CAR
CAR
NEO
NEO
NEO
CAR
NEO
CAR
NEO
CAR
CAR
CAR
CAR
CAR
NEO
CAR
CAR
CAR
CAR
NEO
CAR
NEO
CAR
table.
Adm- Animal (b)
skn-rat
orl-rat
orl-mus
orl-mus
orl-mus
scu-mus
imp-mus
orl-rat
scu-rat
orl-rat
orl-rat
scu-rat
scu-rat
orl-rat
scu-rat
scu-rat
orl-rat
scu-rat
orl-rat
scu-rat
scu-rat
scu-rat
scu-rat
(b) Method of administration and animal (see list of abbreviations and acronyms).
-------
TABLE G-4. ORAL TOXICITY (RAT) - ORGANIC
DYES AND PIGMENTS, RAW
MATERIALS
Rating
Order
1
2
3
4
5
6
7
8
9
10
OOP
Item
Number (a)
29
15
7
3
22
11
2
9
18
30 (c)
LD50,
rag/kg
20
60
75
115
148
698
1830
2060
3200
5000
Carcinogen (b)
+
+
—
—
—
—
—
—
—
—
(a) Item number of compound in Organic Dyes and
Pigments Table B-l.
(b) A plus (+) indicates that this compound is a
known or suspected carcinogen.
(c) Production volume 3100 (6658).
678
-------
TABLE G-5. ORAL TOXICITY (RAT) - ORGANIC DYES
AND PIGMENTS, INTERMEDIATES
ODP
Rating Item LD50, 1973 Production
Order Number (fl) mg/kg Carcinogen ft) Volume, MM kg
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
1 to
2
667
51 to
84
101 to
499
445
459
278
63
301 to
480
645
555
85
668
750
764
501 to
96
97
226
76
47
95
701 to
112
423
635
50(c»d)
30 -
30 - 0.45
100
65 +
300 (e»f)
120
144
224 +
288
300
500
301 +
375
400
418 - 0.3
447
464
467
700
535
535
620 +
648
664
681 - 0.8
1000
704
717
727 +
(Continued)
679
-------
TABLE G-5. (Continued)
Rating
Order
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
ODP
Item LD50, 1973 Production
Number (fl) mg/kg Carcinogen^) Volume, MM kg
633
10
61
743
225
1001 to
277
105
77
748
1501 to
58
343
44
11
2001 to
466
20
613
427
669
471
3001 to
716
98
12
451
> 4000
380
779 +
800 - 1.7
880
974 +
1000 +
1500
1070
1400
1500
1500
2000
1620
1640
1650
1830
3000
2230
2400
2420
2460
2828
2830
4000
3020
3249
3350
3360
4250
Footnotes on following page.
680
-------
Footnotes for Table G-5.
(a) Item number of compound in Organic Dyes and Pigments
Table B-2.
(b) A plus (+) indicates that this compound is a known or
suspected carcinogen.
(c) LD50 value range.
(d) Item number 758 has LD50, oral-bdw = 3. Item No. 291,
Ibid - 42.
(e) Item numbers 64, 72, 81, and 390 have LD50, oral-bdw »
100.
681
-------
TABLE G-6. ORAL TOXICITY (RAT) - ORGANIC
DYES AND PIGMENTS, DYES
Rating
Order
1
2
3
4
5
6
7
8
OOP
Item
Number (a)
446
14
598
599
655
631
839
447
LD50,
mg/kg
535
800
1000
1000
1895
2000
2000
3249
1973 Production
Volume, MM kg
—
—
—
155
—
—
— —
(a) Item number of compound in Organic
Dyes and Pigments Table B-3.
682
-------
TABLE G-7. ORGANIC DYE AND PIGMENT HUMAN AND ANIMAL TOXICITY AND
CARCINOGEN DATA ADDED DURING 1979 REVISION(a»b)
Item
No.
3
9
10
15
Human
Toxicity
LD50:50 mg/kg, orl
LDLo:500 mg/kg, orl
LDLo:50 mg/kg, orl
Animal
Toxicity
LD50:20 mg/kg
Carcinogen
—
ivn-rbt
18 — LD50:210 mg/kg
ipr-mus
28 — LDLorll mg/kg
ivn-rbt
30 LDLo:50 mg/kg, orl
(a) All new human toxicity data are included. All this data are
from reference 39, as cited in reference 2, 1977 edition.
Animal data includes all new LD50 or LDLo data _< 500 mg/kg
and all LC50 or LCLo data <_ 1000 ppm or 200 mg/m3. No new
teratogenic, mutagenic, or carcinogen data were found for
the items in Table B-l.
(b) Update of Table G-5, OOP Raw Materials.
683
-------
APPENDIX H
USSR MAXIMUM ALLOWABLE CONCENTRATIONS OF 'HARMFUL COMPOUNDS IN
WORKING - AREA AND INHABITED AREA ATMOSPHERES
TABLE H-l. COMPARISON OF UNITED STATES AND USSR OCCUPATIONAL STANDARDS
IOC
Number
3
7
8
9
11
13
14
15
17
19
20
24
30
33
39
48
49
56
57
60
61
62
67
68
Compound Name
Acetaldehyde
Acetic acid
Acetic anhydride
Acetone
Acetonitrile
Acetylene
Acrolein
Acrylamide
Acrylonitrile
Allyl alcohol
Allyl chloride
n-Amyl acetate
Aniline
o- and p-Anisidine
Benzene
p-Benzoquinone
Benzo trichloride
Biphenyl
Bisphenol A
Butadiene
Butane
n-Butanol
n-Butyl acetate
sec-Butyl acetate
USOSU),
ppm
200
10
5
1000
40
20% may cause
headache in
hmns; 40% may
cause
collapse'0)
0.1
20s (d)
2s
1
100
5s
—
IQ(C)
0.1
l(0
0.2
0.5
1000
500 (c)
100
150
200
mg/
USOS
360
25
20
2400
70
0.25
0.3s (b)
45s
5s
3
525
19s
0.5s
—
0.4
—
l(c)
2.8
2200
—
300
710
950
MAC<^
5
5
—
200
—
0.7
0.5
2
—
100
Is
Is
5s
0.05
0.5 or
0.2
—
5
—
300
10
200
—
(Continued)
684
-------
TABLE H-l. (Continued)
IOC
Number
69
71
72
73
79
84
85
86
94
101
111
112
113
111G
114
116
122
123
124
125
126
129
133
134
135
136
137
143
160
Compound Name
tert-Butyl acetate
sec-Butyl alcohol
tert-Butyl alcohol
n-Butylamine
tert-Butyl toluene
Carbon disulfide
Carbon tetrabromide
Carbon tetrachloride
Chlorobenzene
Chloroform
m-Cresol
o-Cresol
p-Cresol
Cresylic acid
Cro tonaldehyde
Cumene
Cyclohexane
Cyclohexanol
Cyclohexanone
Cyclohexene
Cyclohexylamine
Diacetone alcohol
o-Dichlorobenzene
p-Dichlorobenzene
Dichlorodif luoromethane
1 , 2-Dichloroethylene
Dichloroethylether
Diethylamine
Dimethylamine
usos(a>,
ppm
200
150
100
C 5s
-------
TABLE H-l. (Continued)
IOC
Number
lei
163
164
167
168
176
179
185
187
188
189
192
193
194
196
201
202
203
204
205
211
213
214
216
217
221
222
227
228
Compound Name
N,N-Dimethylaniline
N, N-Dimethylf ormamide
Dimethyl sulfate
m-Dinitrobenzene
p-Dinitrobenzene
p-Dioxane
Diphenyl oxide (phenyl ether)
Epichlorohydrin
Ethanol
Ethanolamine
Ethyl acetate
Ethylamine
Ethylbenzene
Ethyl bromide
Ethyl chloride
Ethylene chlorohydrin
1 , 2-Ethanediamine
Ethylene dibromide
Ethylene dichloride
Ethylene glycol
Ethylene glycol monobutyl ether
Ethylene glycol monoethyl ether
Ethylene glycol monoethyl ether
acetate
Ethylene glycol monoethyl ether
Ethylene glycol monomethyl ether
acetate
Ethylene oxide
Ethyl ether
Formaldehyde
Foramide
usos(a),
ppm
5s
10s
Is
—
—
100s
1
5s
1000
3
400
10
100
200
1000
5s
10
C 20
50
100
50s
200s
100s
25s
25s
50
400
3
20
USDS
25s
30
5
Is
Is
360s
7
19s
1900
6
—
18
435
890
2600
16s
25
—
260
240
740
540
80
120
90
1200
—
—
mg/M3
MAC
0.2
10
—
Is
Is
10s
—
1
1000
—
200
—
—
5
50
0.5
2
—
10s
—
—
—
—
—
1
300
0.5
3
(Continued)
686
-------
TABLE H-l. (Continued)
IOC
Number
229
232
238
242
243
244
245
248
249
255
258
259
260
263
265
267
270
273
275
276
277
279
280
281
282
284
286
287
288
289
Compound Name
Formic acid
Glycerine
Hexachloroethane
Hexylene glycol
Hydrogen cyanide
Hydroquinone
Isoamyl alcohol
Isobutanol
Isobutyl acetate
Isophorone
Isopropyl acetate
Isopropyl alcohol
Isopropyl amine
Ketene
Maleic anhydride
Mesityl oxide
Methacrylonitrile
Methyl acetate
Methyl alcohol
Methyl amine
N-Methyl aniline
Methyl chloride
Methyl cyclohexane
Methyl cyclohexanol
Methyl cyclohexanone
Methylene chloride
Methyl ethyl ketone
Methyl formate
Methyl isobutyl carbinol
Methyl isobutyl ketone
ppm
5
—
Is
25(0
10s
—
100
100
150
25
250
400
5
0.5
0.25
25
Is
200
200
10
2s
100
500
100
100s
500
200
100
25
100
USDS
9
io<0
10
125
11
2
360
300
700
140
950
980
12
0.9
1
100
—
610
260
12
9s
—
2000
470
—
—
590
250
100
410
mg/M3
MACW
—
—
—
—
—
—
—
—
—
—
—
—
1
—
1
—
—
100
5
1
—
5
50
—
—
—
200
—
—
—
(Continued)
687
-------
TABLE H-l. (Continued)
IOC
Number
292
294
295
302
306
307
310
311
312
313
314
322
323
327
328
331
336
337
338
347
350
355
356
357
358
368
375
377
387
391
Compound Name
a-Methyl styrene
Morpholine
Naphthalene
Nitrobenzene
Nitroethane
Nitromethane
1-Nitropropane
2-Nitropropane
o-Nitrotoluene
p-Nitro toluene
m-Nitrotoluene
Pentaerythritol
n-Pentane
Perchloroethylene
Perchloromethylmercaptan
Phenol
p-Phenylenediamine
Phosgene
Phthalic anhydride
Propane
n-Propyl alcohol
Propylene dichloride
Propylene oxide
Pyridine
Resorcinol
Styrene
1,1,2, 2-Tetrachloroethane
Tetraethyl lead
o-Toluidine
1,1, 2-Trichloroethane
usos(a),
ppm
C 100
20s
10
Is
100
100
25
25
5s
5s
5s
—
1000
100
0.1
5a
—
0.1
2
1000
200
75
100
5
10 <')
100
5
5s
10s
mg/M3
USDS
480
70
50
5
310
250
90
90
30
30
30
10(c)
2950
—
0.8
19
O.ls
0.4
12
—
500
350
240
15
—
35
117 yg/M3
22s
45s
MAC(b)
5
0.5
20
3
30
30
30
—
—
—
—
—
—
10
1
5s
—
0.5
1
—
10
10
Is
5
5
5
5 yg/M3
3s
—
(Continued)
688
-------
TABLE H-l. (Continued)
IOC
Number Compound Name
392 Trichloroethylene
393 Trichlorofluoromethane
394 1,2, 3-Tr ichloropropane
395 1,1, 2-Trichloropropane
397 Triethylamine
403 Vinyl acetate
404 Vinyl chloride
405 Vinylidene chloride
406 Vinyl toluene
407 m-Xylene
408 o-Xylene
409 p-Xylene
415G Xylidene (mixed)
(a) United States Occupational Standards,
Chemical Substances (1975 Edition).
USOS(a),
ppm
100
1000
50
1000
25
10
1
H)(c)
100
100
ioo(°)
100
-------
TABLE H-2. MAXIMUM ALLOWABLE CONCENTRATIONS OF HARMFUL COMPOUNDS IN
WORKING-AREA ATMOSPHERE
-------
TABLE H-2. (Continued)
Item
Number
32
33
34
35
36
37
38
40
41
42
46
47
48
49
51
52
53
55
56
57
59
60
61
62
63
65
66
67
Compound Name
Benzine solvent (on conversion to C) (petroleum
distillate, mostly aliphatic)
Benzine-fuel (shale, cracking and others) (on
conversion to C)
Benzoyl chloride
Benzene
Benzo trif luoride
Benzo trichloride
p-Benzoquinone
Bischloromethylbenzene
Bischloromethylxylene
Bischloromethylnaphthalene
Bromocetopropylacetate
Bromobenzene
Bromoform
Butyl acetate
Butyl acrylate
Butyl ester of 5-chloromethyl-l-furoic acid
Butyl ester of 2-furoic acid
Butynediol
Butyphos (tributyltrithiophosphate)
Valerianic acid
Vinyl acetate
Vinylbutyl ether
2-Vinylpyridine
Vinyltoluene
Vinyl chloride
Hexamethylene diamine
Hexamethylene diisocyanate
Hexamethylene imine
MAc(b),
mg/M3
300
100
5
5s
100
0.2
0.05
1
1
0.5
0.5
3
5
200
10
0.5
0.5
1
0.6s
5
10
20
0.5s
50
30
1
0.05s
0.5s
Physical
State^
V
V
V
V
V
V
V
V
V
V
V
V
V
V
V
a
a
v+a
v+a
V
V
V
V
V
V
V
V
V
(Continued)
691
-------
TABLE H-2. (Continued)
Item
Number
68
69
70
71
72
73
78
79
80
84
85
86
87
88
89
91
93
94
95
96
97
98
99
100
101
102
103
104
105
Compound Name
Hexachlorocyclohexane
y-hexachlorane (y-hexachlorocyclohexane)
Hexachloroacetone
Hexachlo rob enz ene
Hexachlorocyclopentadiene
Hexafluoropropylene
Hydrazine-hydrate, hydrazine and its derivatives
(3-Hydroxyethylmercaptan
Isopropylbenzene hydroperoxide
Decalin
1 , 2-Dibromopropane
Divinyl (1,3-butadiene pseudobutylene)
Perfluoroacetone dihydrate
Diisopropylamine
Disopropylbenzene
Dicumyl methane
Dimethylamine
Dime thylanil ine
Dimethylbenzylamine
Dimethyldioxane
Dimethyl sulphide
Dimethylterephthalate
Dimethyl formamide
Dimethylchlorothiophosphate
Dimethylethanolamine
Dinyl (mixture of 25% diphenyl and 75% diphenyl
oxide)
Dinitrobenzene
4 , 6-Dinitro-2-isopropylphenol
Dinitro-o-cresol
MAC(b),
mg/M3
0.1
0.05s
0.5
0.9s
0.01s
5
O.ls
Is
1
100
5
100
2s
5
50s
5s
1
0.2s
5
10
50s
0.1
10
0.5
5
10
Is
0.05s
0.05s
Physical
State(c)
v+a
v+a
V
v+a
V
V
V
V
V
V
V
V
V
V
V
a
V
V
V
V
V
v+a
V
V
V
v+a
v+a
v+a
v+a
(Continued)
692
-------
TABLE H-2. (Continued)
Item
Number
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
Compound Name
Dinitro toluene
Dinitro phenol
Dinitro-secondary-butylphenol
Dinitrile of adipic acid
Dinitrile of perf luoroglutaric acid
Dinitrile of perfluoroadipic acid
Dinitrothiocyanogenbenzene (probably 3,5-
dinitro-1-thiocyanobenzene)
Dioxane
Diptane (diisopropyl trichloroallylthiocarbamate)
Di-n-Propylamine , tri-n-propylamine
Ditertiarybutyl peroxide
Ditolylmethane
Chlorinated diphenyls
Chlorinated diphenyl oxide
Diphenylolpropane (Bisphenol A)
3,4-Dichloroaniline
Dichlorobenzene
1 , 3-Dichlorobutene-2
Dichlorohydrin
1,2-Dichloroisobutane
1 , 3-Dichloroisobutylene
3,3-Dichloroisobutylene (symmetric isomer)
3 , 3-Dichloromethyloxacyclobutane
2, 3-Dichloro-l ,4-naphthoquinone
3 , 4-Dichloronitrobenzene
1 , 2-Dichloropropane
1 , 3-Dichloropropylene
2 , 3-Dichloropropylene
3 , 4-Dichlorophenylisocyanate
MAc(b),
mg/M3
Is
0.05s
0.05s
20
0.05
0.1
2s
10s
1
2
100
1
Is
0.5s
5
0.5s
20s
1
5
20
0.5
0.3
0.5
0.5
Is
10
5
3
0.3
Physical
State(c)
v+a
v+a
v+a
V
V
V
a
V
v+a
V
V
v+a
V
V
a
V
V
V
V
V
V
V
V
a
V
V
V
V
V
(Continued)
693
-------
TABLE H-2. (Continued)
Item
Number
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
162
163
164
168
171
172
Compound Name
Dichlorophenyltrichlorosilane (HC1 verification
obligatory)
Dichloroethane
1, 1-Dichloroethylene (vinylidene chloride)
Dicyclopentadiene
Diethylamine
3-Diethylaminoethylmercaptane
Diethylaminoethyl methacrylate
Diethylbenzene
Diethyl ester of perfluoroadipic acid
Diethyl ester of perfluoroglutaric acid
Diethyl chlorothiophosphate
Diethylethanolamine
Dodecylmercaptane (tertiary)
Isobutylene
Isobutylene chloride
Isoprene
Isopropylaminodiphenylamine
Isopropylbenzene (cumene)
Isopropylnitrate
Isopropylnitrite
Isopropylchlorocarbonate
Isopropyl-N-phenylcarbamate
Isopropyl-N-3-chlorophenylcarbamate
Camphor
Caprolactam
Caproic acid
Kerosene (in conversion to C)
Crotonaldehyde
Butylic K nthogenate
mg/M3'
1
10s
10s
Is
30
Is
800
10
0.1
0.1
1
5
5
100
0.3
40
2
50
5
Is
0.1
2
2
3
10
5
300
0.5
10
Physical
V
V
V
V
V
V
V
V
V
V
V
V
V
V
V
V
a
V
V
V
V
v+a
v+a
V
a
V
V
V
a
(Continued)
694
-------
TABLE H-2. (Continued)
Item
Number
173
174
175
177
178
179
180
185
186
189
190
191
192
193
194
195
196
197
198
199
200
203
205
206
207
208
209
210
211
212
Compound Name
Xylidine
Xylene
Ligroin (in conversion to C)
Butyraldehyde
Butyric anhydride
Butyric acid
Maleic anhydride
Methacrylic acid
Methacrylic acid anhydride
Methyl acetate
Methyl bromide
Methyl chloride
2-Methyl-5-vinylpyridine
6-Methyl-2-vinylpyridine
Methyl hexyl ketone
Methylene bromide
Methylene chloride
Methyl vinyl ketone
Methyl thiophene (2 and 3 isomers)
Methyldihydropyrane
Methylisothiocyanate
1-Methylnaphthaline, 2-methylnaphthaline
Methyl acrylate
Methylpyrrolidone
Methyl propyl ketone
Methylf luorophenyldichlorosilane (obligatory
HC1 control)
Methyl chloroacetate
Me thyl cy clohexane
Methyl ethyl ketone
2-Methyl-5-ethylpyridine
mg/M3
3s
50
300
0.5
1
10
1
10
1
100
1
5
2s
0.5s
200
10
50
O.ls
20
5s
O.ls
20
20
100
200
1
5
50
200
2s
Physical
State'0'
V
V
V
V
V
V
v+a
V
V
V
V
V
V
V
V
V
V
V
V
V
V
V
V
v+a
V
V
V
V
V
V
(Continued)
695
-------
TABLE H-2. (Continued)
Item
Number
217
218
219
220
221
222
223
224
225
226
229
230
231
232
236
237
238
239
240
241
242
243
244
245
246
249
250
252
Compound Name
Monobutylamine
Monovinylacetylene
Monoisopropylamine
Monomethylamine
m-Monomethyl ether of resorcinol
Monochloroodibromotrifluoroethane
Monochlorodimethyl ether
Monochloro-, dichlorostyrene
Monochlorocyclohexane
Morpholine
Sodium triocyanate (technical)
Naphthalene
Chlorinated naphthalines (high)
a-Naphthoquinone
Nicotine sulphate (3-(l-methyl-2-pyrrolidyl)
pyridine sulphate)
Nitrophene (containing alkylphenols 72.5-67.5%)
Acrylonitrile
p-Nitroanisole
p-Nitro aniline
o-Nitroaniline
m-Nitrobenzotrifluoride
Nitromethane, nitroethane, nitropropane,
nitrobutane
Nitroxylene
Nitro compounds of benzene
Nitroform
Nitrochlorobenzene, dinitrochlorocompounds of
benzene
Nitrocyclohexane
p-Oxydiphenylamine
MAC(b),
mg/M3
10
20
1
1
0.5s
50
0.5
50
50
0.5s
50
20
0.5s
0.1
0.1
1
0.5s
3
O.ls
0.5s
1
30
5s
3s
0.5
Is
1
0.5
Physical
Stated)
V
V
V
V
V
V
V
V
V
V
a
V
V
V
v+a
V
V
V
a
a
V
V
V
V
V
V
V
V
(Continued)
696
-------
TABLE H-2. (Continued)
Item
Number
253
254
255
257
258
259
260
261
262
263
264
265
266
275
276
277
278
279
280
291
294
295
298
299
300
301
302
303
304
Compound Name
Oxycarbamate
Octamethyl (octamethyltetramide of pyrophosphoric
acid)
Octafluorodichlorocyclohexene
Pentaf luoropropionic acid
Pentachloroacetone
Pentachloronitrobenzene
Pentachlorophenol
Pentachlorophenolate of sodium
Perfluoroisobutylene
Perchloromethylmercaptan
Picolines (mixture of isomers)
Piperidine
Pyridine
Propanide (3,4-dichloropropione anilide)
Propylene oxide
n-Propylamine
Propylacetate
Propylpropionate
Propionic aldehyde
Carbon disulfide
Spirits of turpentine (on conversion to C)
Solvent naphtha (on conversion to C)
Unsaturated alcohols of the fatty series (allyl,
crotonyl, etc.)
Methyl alcohol (methanol)
Ethyl alcohol
Propyl alcohol
Amyl alcohol
Acetopropyl alcohol
Butyl alcohol
mg/M3
0.5
0.2s
1
2
0.5
0.5
0.1
0.1
0.1
1
5
0.2
5
0.1
Is
5
200
70
5
10
300
100
2
5
1000
10
10
10
10
, Physical
State(c)
v+a
v+a
V
V
V
v+a
v+a
v+a
V
V
V
V
V
a
V
V
V
V
V
V
V
V
V
V
V
V
V
V
V
(Continued)
697
-------
TABLE H-2. (Continued)
Item
Number
305
306
307
308
309
310
311
312
313
314
315
316
325
326
327
328
329
330
331
332
333
335
336
337
339
341
343
345
346
347
Compound Name
n-Hexylic alcohol
n-Heptyl alcohol
n-Octyl alcohol
n-Nonyl alcohol
n-Decyl alcohol
Propargyl alcohol
Octafluoroamyl alcohol
Trifluorobutyl alcohol
Trifluoroethyl alcohol
Tetrafluoropropyl alcohol
Isooctyl alcohol (2-ethylhexanol)
Styrene, a-Methylstyrene
Terephthalic acid
Tetrabromethane
Tetrahydrofuran
Tetralin
Tetranitrome thane
Tetrachlorohexatriene
Tetrachloropropane, tetrachloropentane, tetra-
chlorohep tane
Tetrachlorononane
Tetrachlorundecane
Tetrachloroethylene
Tetraethyl lead
Tetraethoxysilane
Thioglycolic acid
Thiophene
Thiuram, TMTD (tetramethylthiuram disulfide)
Toluidine
Toluene diamino
Toluene diisocyanate
MAc(b>,
mg/M3
10
10
10
10
10
1
20
20
10
20
50
5
0.1
1
100
100
0.3
0.3s
1
1
5
10
0.005s
20
O.ls
20
0.5
3s
2s
0.5
Physical
State(c)
V
V
v+a
v+a
v+a
V
V
V
V
V
V
V
v+a
V
V
V
V
V
V
v+a
v+a
V
V
V
v+a
V
a
V
v+a
V
(Continued)
698
-------
TABLE H-2. (Continued)
Item
Number
348
350
351
352
353
355
356
357
358
359
360
361
362
363
365
366
367
368
369
370
371
372
375
376
377
380
381
Compound Name
Toluene
Tertiary-butylperacetate
Tertiary-butylperbenzoate
Tricresylphosphate, containing more than 3%
orthoisomers
Tricresylphosphate, containing less than 3%
orthoisomers
Trimethylamine
Trimethylolpropane
Trinitroluene
1,1, 3-Trichloroacetone
Trichlorobenzene
Trichloropropane
Trichloropropylene
Trichlorosilane (obligatory HC1 verification)
Trichloroethylene
Trichloronaphthalene (mixture of tetra- and
penta-chloronaphthalenes)
Copper trichlorophenolate
Trifluoropropylamine
Trifluoroacetate acid
Trif luorochloropropane
Trifluoroethylamine
Triethylamine
Triethoxysilane
Saturated aliphatic hydrocarbons Cj - CIQ (on
conversion to C)
Carbon tetrachloride
Acetic acid
p-Phenetidine hydrochloride (? chloride)
Phenylmethyldichlorosilane (HC1 control
obligatory)
mg/M3
50
0.1
1
O.ls
0.5s
5
50
Is
0.3
10
2
3
1
10
Is
0.1
5
2
Is
100
10
1
300
20s
5
0.5
1
Physical
Stated)
V
V
V
a
a
V
V
V
V
V
V
V
V
V
v+a
a
V
V
V
V
V
V
V
V
V
a
V
(Continued)
699
-------
TABLE H-2. (Continued)
Item
Number
382
383
385
386
387
392
397
398
402
403
404
405
406
407
408
409
412
414
415
417
418
419
420
422
425
426
427
428
429
430
>
Compound Name
m-Phenoxyphenol
Phenol
Formaldehyde
Formamide
Phosgene
Phthalic anhydride
Furan
Furfural
p-Chloraniline
Trichloroacetyl chloride
Acid chloride of acrylic, methacrylic acids
m-Chloroaniline
Chloroacetopropylacetate
Chlorobenzene
1 , 3-Chlorobromopropane
4-Chlorobenzophenol-2-carboxylic acid
5-Ethoxyphenyl-l, 2-thiazothionic chloride
Chloromethyltrichlorosilane (HC1 control
obligatory)
Chloroprene
Chloropropionic acid
Chloropelargonic acid
m-Chlorophenylisocyanate, p-chlorophenylisocyanate
m-Chlorophenol
2-Chloroethanesulfochloride
Cyanuric chloride (trichlorotriazine)
Free cyanamide
Cyclohexane
Cyclohexanone
Cyclohexylamine
Cyclohexylamine carbonate
mg/M3
Is
5s
0.5
3
0.5
1
0.5
10
0.3s
O.ls
0.3
0.05s
2
50s
3
1
0.2
1
2
5
5
0.5
Is
0.3s
0.1
0.5s
80
10
1
10
Physical
State(c>
V
V
V
V
V
v+a
V
V
V
V
V
V
V
V
V
a
a
V
V
V
V
V
V
V
V
v+a
V
V
V
V
(Continued)
700
-------
TABLE H-2. (Continued)
Item
Number
431
432
434
440
442
443
444
445
446
447
448
449
450
453
454
455
456
457
Compound Name
Cyclohexylamine chromate
Cyclohexanone oxime
Cyclopentadiene
Epichlorohydrin
2-Ethylhexenal
Ethylacetate
Ethylene oxide
Ethylene diamine
Ethylene imine
Ethylene sulfide
Ethylene diacetate
Ethylene chlorohydrin
Ethylmercaptan
Ethyl ether, diethyl ether
Ethyl toluene
Ethyl bromide
Ethyl chloride
Ether sulfanate (?) (p-chlorophenyl-p-
chlorobenzosulfanate)
MAC
-------
TABLE H-3. MAXIMUM ALLOWABLE CONCENTRATIONS OF HARMFUL
SUBSTANCES IN ATMOSPHERIC AIR OF INHABITED
AREAS - USSR
Maximum
Single
0.30
0.10
0.05
0.35
0.003
2.1
0.1
0.2
3.0
0.03
0.01
1.5
0.07
0.1
0.003
0.005
0.05
0.01
0.05
0.26
0.1
', mg/M3
Average
24 hr
0.10
0.10
0.03
0.35
0.003
0.80
0.1
0.2
1.0
0.03
0.01
0.5
0.07
0.1
0.003
0.012
0.02
0.01
0.05
0.8
0.1
(a) U.S.S.R. Literature on Air Pollution and Related
Occupational Diseases, 15 (1964), translated by
B. S. Levine (available NTIS, PB 179140).
(b) Maximum Allowable Concentration (or MFC, Maximum
Permissible Concentration). MAC's approved by
Chief USSR Government Sanitary Inspector, 20 June
1963.
(c) Apparently a mixture of 25% diphenyl and 75%
diphenyl oxide.
702
-------
TECHNICAL REPORT DATA
(Please read Instructions on the reverse before completing)
1. REPORT NO.
EPA-600/2-80-056
2.
3. RECIPIENT'S ACCESSION NO.
4. TITLE AND SUBTITLE
POTENTIALLY TOXIC AND HAZARDOUS SUBSTANCES IN THE
INDUSTRIAL ORGANIC CHEMICALS AND ORGANIC DYES AND
PIGMENTS INDUSTRIES
5. REPORT DATE
March 1980 issuing date
6. PERFORMING ORGANIZATION CODE
7. AUTHOR(S)
R. A. Markle, A. F. Fentiman, T. R. Steadman and
R. A. Mayer
8. PERFORMING ORGANIZATION REPORT NO
9. PERFORMING ORGANIZATION NAME AND ADDRESS
Battelle's Columbus Laboratories
Columbus, Ohio 43201
10. PROGRAM ELEMENT NO.
1BB610
11. CONTRACT/GRANT NO.
68-02-1323
12. SPONSORING AGENCY NAME AND ADDRESS
Industrial Environmental Research Laboratory-Cin., Ohio
Office of Research and Development
U.S. Environmental Protection Agency
Cincinnati, Ohio 45268
13. TYPE pF REPORT AND PERIOD COVERED
Final 1/20 -6/20/79
14. SPONSORING AGENCY CODE
EPA/600/12
15.SUPPLEMENTARY NOTES This report was submitted in fulfillment of Task No. 56, Contract
No. 68-02-1323. The report covers the period March 30 to Dec. 31, 1976. The report
was revised and updated during the period Jan. 20 to June 20, 1979.
16. ABSTRACT
The objective of this program were identification of the potential hazards associated
with the production and use of industrial organic chemicals (IOC) and organic dyes and
pigments (OOP) and determination of the state of the art of the control and treatment
of potentially hazardous waste generated during manufacture and use of these materials.
The major study outputs are comprehensive master tables of 510 IOC, 142 OOP raw
materials, 722 OOP intermediates and 1458 dyes and pigments containing correlated
compounds identification, toxicity data, chemical production process information.
Eight "priority rating" lists containing chemicals ranked in order of quantitative
toxicity or production data and twelve "priority" lists with chemicals presented
alphabetically were extracted from the master tables. Although about 150 compounds
are thus shown to pose potential toxic hazards, the toxicity data were found to vary
widely in both availability, and in precision where available in replicate. Conse-
quently these simplistically prepared lists must be used with caution. Pollution
control and waste treatment technologies applicable to these industries are discussed
and summarized, but "best" technologies for specific compounds/processes are not
specified.
17.
KEY WORDS AND DOCUMENT ANALYSIS
DESCRIPTORS
b.IDENTIFIERS/OPEN ENDED TERMS
c. COSATI Field/Group
Organic compounds
Toxicity
Organic compounds
Toxicity
18. DISTRIBUTION STATEMENT
Release to Public
18. SECURITY CLASS (This Report)
Unclassified
21. NO. OF PAGES
715
20. SECURITY CLASS (Thispage)
Unclassified
22. PRICE
EPA Form 2220-1 (R»v. 4-77) PREVIOUS COITION is OBSOLETE
703
US GOVERNMENT PRINTING OFFICE: 1980-657-146/5611
-------
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Environmental Protection
Agency
Center for Environmental Research
Information
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Fees Paid
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Agency
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Penalty for Private Use, $300
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