United States            Office of Pollution        June 1999
                    Environmental Protection   Prevention and Toxics     EPA 745-B-99-011
                    Agency               Washington, DC 20460
                  TOXICS RELEASE INVENTORY
     List of Toxic Chemicals within Warfarin Category
       Section 313 of EPCRA requires certain facilities manufacturing, processing, or otherwise using
listed toxic chemicals to report their environmental releases of such chemicals annually. Beginning with
the 1991 reporting year, such facilities also must report pollution prevention and recycling data for such
chemicals, pursuant to section 6607 of the Pollution Prevention Act, 42 U.S.C. 13106.  When enacted,
section 313 established an initial list of toxic chemicals that was comprised of more than 300 chemicals
and 20 chemical categories. Section 313(d) authorizes EPA to add chemicals to or delete chemicals
from the list, and sets forth criteria for these actions.
                                     CONTENTS


       Section 1.    Introduction	2


       Section 2.    CAS Number List of Chemicals within the Warfarin Category	4


       Section 3.    CAS Number List of Mixtures Within the Warfarin Category  	5

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                                   Section 1. Introduction
       On November 30, 1993 EPA added 21 chemicals and 2 categories to the list of toxic
chemicals under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986
(EPCRA) (58 FR 63500). These additions are described at 40 CFR 372.65, and are effective
January 1, 1994 for reports due July 1995.  Two chemical categories (ethylenebisdithiocarbamic acid
(EBDC), salts and esters; warfarin and salts) are included in these additions. At the time of the
addition, EPA indicated that the Agency would work with the public and the regulated community to
develop, as appropriate, interpretations and guidance the Agency determines are necessary to facilitate
accurate reporting for these categories.  This document constitutes such guidance for warfarin and salts.

       EPCRA section 313 requires threshold determinations for chemical categories to be based on
the total of all chemicals in the category manufactured, processed, or otherwise used. For example, a
facility that manufactures three members of a chemical category would count the total amount of all
three chemicals manufactured towards the manufacturing threshold for that category.  When filing
reports for chemical categories, the releases are determined in the same manner as the thresholds. One
report is filed for the category and all releases are reported on this form.

       The warfarin salts category is subject to the one percent de minimis concentration.  Thus,
mixtures that contain members of these categories equal to or in excess of the de minimis should be
factored into threshold and release determinations.

       Any compound which has a warfarin salt component is reportable.  EPA is providing the
following list of CAS numbers and chemical names to aid the regulated community in determining
whether they  need to report the Warfarin category. However, this list is not exhaustive. Jf a facility is
manufacturing, processing, or using a chemical which has a warfarin salt component, they must report to
TRI, even if this chemical does not appear on the following list.

Who Must Report

       A plant, factory, or other facility is subject to the provisions of Section 313, if it meets all three
of the following criteria:

             It is included in a covered Standard Industrial Classification (SIC) code as listed in the
              following  table; and

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Industrial Sector SIC code
Manufacturing
Metal mining
Coal Mining
Electrical utilities
Treatment, Storage, and Disposal facilities
Solvent recovery services
Chemical distributors
Petroleum bulk terminals
20-39
10 (except 1011, 1081, and 1094)
12 (except 1241)
491 1 , 493 1 , and 4939, limited to facilities that combust coal
and/or oil for the purpose of generating electricity for
distribution in commerce
4953, limited to RCRA Subtitle C permitted or interim status
facilities
7389, limited to facilities primarily engaged in solvent recovery
services on a contract or fee basis
5169
5171
              It has 10 or more full-time employees (or the equivalent 20,000 hours per year); and

              It manufacturers, imports, processes, or otherwise uses any of the toxic chemicals listed
              on the EPCRA Section 313 list in amounts greater than the "threshold" quantities
              specified below.
Thresholds
       Thresholds are specified amounts of toxic chemicals used during the calendar year that trigger
reporting requirements.

       If you manufacture or import any of the listed toxic chemicals, the threshold quantity will be:

              25,000 pounds per toxic chemical or category over the calendar year.

       If you process any of the listed toxic chemicals, the threshold quantity will be:

              25,000 pounds per toxic chemical or category over the calendar year.

       If you otherwise use any of the listed toxic chemicals (without incorporating it into any product
or producing it at the facility), the threshold quantity is:
               10,000 pounds per toxic chemical or category over the calendar year.

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             Section 2.  CAS Number List of Chemicals that have CAS numbers
                                within the Warfarin Category
       EPA is providing the following list of CAS numbers and chemical names to aid the regulated
community in determining whether they need to report for the Warfarin category. However, this list is
not exhaustive. If a facility is manufacturing, processing, or using a chemical which has a Warfarin
component, they must report to TRI, even if this chemical does not appear on the following list.
Table 1. Listing by CAS Number of Each Individual Chemical within the Warfarin and Salts Category
Collective Index Name
Warfarin
2H-l-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, sodium salt
Coumarin, 3-(. alpha. -acetonylbenzyl)-4-hydroxy-, calcium salt
Coumarin, 3-(.alpha.-acetonylbenzyl)-4-hydroxy-, magnesium salt
2H-l-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, potassium salt
2H-l-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, lithium salt
2H-l-benzopyran-2-one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, sodium salt, (S)-
2H-lBenzopyran-2-one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, sodium salt, (R)-
2H-l-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, sodium salt, (.+-.)-
2H-l-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, thallium(l+) salt
Common Name
N/A
Warfarin sodium salt
Warfarin calcium salt
Warfarin magnesium salt
Warfarin, potassium salt
Lithium warfarin
Sodium S-warfarin
Sodium R-warfarin
(.+-.)-Warfarin sodium
Warfarin, thallium salt
CAS
Number
81-81-2
129-06-6
2084-55-1
2084-56-2
2610-86-8
2784-36-3
5543.79.3
36508-91-
5*
51821-81-
9*
67523-25-
5*
 : - Indicates the mixtures under this category

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           Section 3.  CAS Number List of Mixtures Within the Warfarin Category
       EPA is providing the following list of CAS numbers and chemical names for mixtures which
contain Warfarin and its salts. This list will aid the regulated community in determining whether they
need to report for the Warfarin category. However, this list is not exhaustive. If a facility is
manufacturing, processing, or using a mixture that contains Warfarin or a Warfarin salt component,
they must report to TRI, even if this chemical does not appear on the following list. Threshold
calculations for the Warfarin category should account only for the percentage of the Warfarin
component contained in the mixture.
Table 2. Mixtures Containing Warfarin and its Salts
Mixture Name
Benzenesulfonamide, 4-amino-N-2-quinoxalinyl-, mixt. with
4-hydroxy-3-(3 -oxo- 1 -phenylbutyl)-2H- 1 -benzopyran-2-one
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt, mixt. with acetaldehyde, 2-butanone,
N,N-dimethylmethanamine, formaldehyde,
.alpha. -hydro-. omega. -hydroxypoly(oxy-l,2-ethanediyl),
4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one sodium salt and
2,2',2"-nitrilotris[ethanol]
9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol, (3.beta.,5Z,7E,22E)-, mixt. with
4-hydroxy-3-(3 -oxo- 1 -phenylbutyl)- 2H- 1 -benzopyran-2-one
lH-Indene-l,3(2H)-dione, 2-(2,2-dimethyl-l-oxopropyl)-, mixt. with
4-hydroxy-3-(3 -oxo- 1 -phenylbutyl)-2H- 1 -benzopyran-2-one
Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-, mixt. with
4-hydroxy-3-(3 -oxo- 1 -phenylbutyl)-2H- 1 -benzopyran-2-one
Retinol, acetate, mixt. with 4-hydroxy-3-(3-oxo-l-phenylbutyl)- 2H-1 -benzopyran-2-one 12
Antimycin A, mixt. with 4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l- benzopyran-2-one
lH-Indole-3-acetic acid, l-(4-chlorobenzoyl)-5-methoxy-2-methyl-, mixt. with
4-hydroxy-3-(3 -oxo- 1 -phenylbutyl)-2H- 1 -benzopyran-2-one
2-Naphthaleneacetic acid, 6-methoxy-. alpha. -methyl-, (S)-, mixt. with
4-hydroxy-3-(3 -oxo- 1 -phenylbutyl)-2H- 1 -benzopyran-2-one
2H-l,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide, mixt.
with 4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H- 1 -benzopyran-2-one
2H,5H-l,3-Oxazino[5,6-c][l,2]benzothiazine-2,4(3H)-dione, 5-methyl-3-(2-pyridinyl)-,
6,6-dioxide, mixt. with 4-hydroxy-3-(3-oxo-l-phenylbutyl)-2H-l-benzopyran-2-one
Warfarin
Compone
nt
Warfarin
81-81-2
Warfarin
Sodium Salt
129-06-6
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Warfarin
81-81-2
Mixture
CAS
Number
37341-99.4
39366-36-4
54842-06-7
58934-24-0
60177-49-3
63610-50-4
64782-63-4
136153-10-1
136153-11-2
136153-09-8
136153-12-3

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Table 2. Mixtures Containing Warfarin and its Salts
Mixture Name
Benzoic acid, 2-(acetyloxy)-, mixt. with 4-hydroxy-3-(3-oxo-l-
phenylbutyl)-2H- 1 -benzopyran-2-one
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, mixt. with
3,5-Pyrazolidinedione, l,2-diphenyl-4-[2-(phenylsulfmyl)ethyl]-, mixt. with
4-hydroxy-3-(3 -oxo- 1 -phenylbutyl)-2H- 1 -benzopyran-2-one
2H-1 -Benzopyran-2-one, 4-hydroxy-3-(3-oxo-l-phenylbutyl)-, mixt. with
5-[(2-chlorophenyl)methyl]- 4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Warfarin
Compone
nt
Warfarin
81-81-2
Warfarin
X1-X1-9
Warfarin
81-81-2
Warfarin
81-81-2

Mixture
CAS
Number
136153-08-7
136153-13-4
136153-14-5
136153-15-6

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