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Appendix B - Independent Review of Assignments to Documentation Categories
July 14,2000
Reviewer: Hugh -Tilson
Chemical
Variability
Uncertainty
Acetonitrile
Overall Rating-Extensive based on variability and uncertainty narrative in the Toxicological Review
Aldicarb sulfone
RFD Moderate Mimimal
RfC-Not listed Not scored Not scored
Moderate
Not scored
Not scored
Not scored
Minimal
Not Scored
Moderate
Extensive
Not Scored
Extensive
Minimal
Not scored
Minimal
Moderate
Not scored
Extensive
Cancer-Not listed
Overall Rating-Minimal
Apollo
RfD
RfC-Not listed
Cancer
Overall Rating-Minimal
Arsenic, inorganic
RfD
RfC-Not listed
Cancer
Overall Rating-Extensive
Barium and compounds
Overall Rating-Extensive for both variability and uncertainty based on Toxicological Review
Benomyl
RfD Minimal Minimal
RfC-Not listed Not Scored Not Scored
Cancer-Not listed Not Scored Not Scored
Overall Rating-Minimal
Bentazon
Overall Rating-Extensive for both variability and uncertainty based on Toxicological Review
Benzene
Overall Rating-Extensive for both variability and uncertainly based on Support Documents on IRIS
Beryllium and compounds
Overall Rating-Extensive for both variability and uncertainty based on Toxicological Review
beta-Chloronaphthalene
RfD
RfC-Not listed
Cancer-Not listed
Overall Rating-Minimal
Bis(chloromethyl)ether
RfD-Not listed
RfC-Not listed
Cancer
Overall Rating-Moderate
Butylphthalyl butylglycolate
RfD
RfC-Not listed
Cancer-Not listed
Overall Rating-Minimal
Minimal
Not Scored
Not Scored
Not scored
Not scored
Moderate
Minimal
Not scored
Not scored
Minimal
Not Scored
Not Scored
Not scored
Not scored
Minimal
Minimal
Not scored
Not scored
B-l
-------
Appendix B - Independent Review of Assignments to Documentation Categories
July 14,2000
Reviewer Hugh Tilson
Chemical Variability Uncertainty
Carboxin
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Chlordane
Overall Rating-Extensive for both variability and uncertainty based on Toxicological Review
Chlorocyclopentadiene
RfD-Not listed Not scored Not scored
RfC-Not listed Not scored Not scored
Cancer Minimal • Minimal
Overall Rating-Minimal
Chlorsulfuron
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Chromium III, insoluble salts
Overall Rating-Extensive for both variability and uncertainty based on Toxicological Review
Chromium VI
Overall Rating-Extensive for both variability and uncertainty based on Toxicological Review
Cumene
Overall Rating-Extensive for both variability and uncertainty based on Toxicological Review
Cypermethrin
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Cyromazine
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Danitol
RfD Moderate Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Moderate
Dibromo-3-chloropropane, 1,2-
RfD-Not listed Not scored Not scored
RfC Moderate Minimal
Cancer-Not listed Not scored Not scored
Overall Rating-Moderate
Dibromobenzene, 1,4-
RfD Minimal Minimal
B-2
-------
Appendix B - Independent Review of Assignments to Documentation Categories
My 14, 2000
Reviewer: Hugh Tilson
Chemical
RfC-Not listed
Cancer-Not listed
Overall Rating-Minimal
Dibromodichloromethane
RfD-Not listed
RfC-Not listed
Cancer
Variability
Not scored
Not scored
Uncertainty
Not scored
Not scored
Not scored Not scored
Not scored Not scored
Minimal Minimal
Overall Rating-Minimal (on the basis that a classification was made without presenting data)
Dichlorodiphenyltrichloroethane, p,p'-
Minimal
Not scored
RfD
RfC-Not listed
Cancer Minimal
Overall Rating-Minimal
Dieldrin
RfD Minimal
RfC-Not listed Not scored
Cancer Minimal
Overall Rating-Minimal
Dimethyl phthalate
RfD-Not listed Not scored
RfC-Not listed Not scored
Cancer Minimal
Overall Rating-Minimal
Dimethylfbrmamide, N,N-
RfD-Not listed Not scored
RfC Moderate
Cancer-Not listed Not scored
Overall Rating-Moderate
Dinitrobenzene, o-
RfD-Not listed
RfC-Not listed
Cancer
Minimal
Not scored
Minimal
Minimal
Not scored
Minimal
Not scored
Not scored
Minimal
Not scored
Minimal
Not scored
Not scored Not scored
Not scored Not scored
Minimal Minimal
Overall Rating-Minimal (classified as non carcinogenic, supporting data are largely mechanistic and
not described in detail)
Diphenamid
Minimal Minimal
Not scored Not scored
Not scored Not scored
RfD
RfC-Not listed
Cancer-Not listed
Overall Rating-Minimal
Ethylene glycol
RfD Minimal
RfC-Not listed Not scored
Cancer-Not listed Not scored
Overall Rating-Minimal
Ethylene glycol monobutyl ether
Minimal
Not scored
Not scored
B-3
-------
Appendix B - Independent Review of Assignments to Documentation Categories
July 14,2000
Reviewer: Hugh Tilson
Chemical Variability Uncertainty
Overall Rating-Extensive for both variability and uncertainty based on lexicological Review
Fluorine (soluble fluoride)
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored - Not scored
Overall Rating-Minimal
Fomesafen
RfD-Not listed Not scored Not scored
RfC-Not listed Not scored Not scored
Cancer Minimal Minimal
Overall Rating-Minimal
Furmecyclox
RfD-Not listed Not scored Not scored
RfC-Not listed Not scored Not scored
Cancer Minimal Minimal
Overall Rating-Moderate
Hexachlorobenzene
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer Minimal Minimal
Overall Rating-Minimal
Hexachlorodibenzo-p-dioxin, mixture
RfD-Not listed Not scored Not scored
RfC-Not listed Not scored Not scored
Cancer Minimal Minimal
Overall Rating-Minimal
Hexachlorophene
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Hexazinone
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed ' Not scored Not scored
Overall Rating-Minimal
Maneb
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not liested Not scored Not scored
Overall Rating-Minimal
Manganese
RfD
RfC
Cancer
Moderate
Extensive
Not scored (moderate narrative)
B-4
Extensive
Extensive
Not scored (not carcinogenic)
-------
Appendix B - Independent Review of Assignments to Documentation Categories
July 14,2000
Reviewer: Hugh Tilson
Chemical Variability Uncertainty
Overall Rating-Extensive
Metalaxyl
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Methamidophos
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Methyl methacrylate
Overall Rating- Extensive for both variability and uncertainty based on Toxicological Review
Methylene diphenyl diisocyanate
Overall Rating- Extensive for both variability and uncertainty based on Toxicological Review
Methylphenol, 4-
RfD-Withdrawn Not scored Not scored
RfC-Not listed Not scored Not scored
Cancer Moderate Minimal
Overall Rating- Moderate
Naphthalene
Overall Rating-Extensive based on both variability and uncertainty in Toxicological Review
N-Nitroso-N-methylethylamine
RfD-Not listed Not scored Not scored
RfC-Not listed Not scored Not scored
Cancer Moderate Minimal
Overall Rating- Moderate
Octabromodiphenyl ether
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not care. Not scored Not scored
Overall Rating-Minimal
Pentachlorophenol
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer Moderate Minimal
Overall Rating-Minimal
Phosmet
RfD Minimal Minimal
RfC Not scored Not scored
Cancer Not scored Not scored
Overall Rating-Minimal
Prochloraz
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
B-5
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Appendix B - Independent Review of Assignments to Documentation Categories
July 14,2000
Reviewer: Hugh Tilson
Chemical
Variability
Moderate
Uncertainty
Minimal
Cancer
Overall Rating-Minimal
Pronamide
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Propargite
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer Not scored Not scored
Overall Rating-Minimal
Pursuit
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Pydrin
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Sodium azide
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Tetrachlorovinphos
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed Not scored Not scored
Overall Rating-Minimal
Toluene diisocyanate mixture, 2,4-72,6-
RfD-Not listed Not scored Not scored
RfC- Extensive Moderate
Cancer-Not listed Not scored Not scored
Overall Rating-Extensive
Tributyltin oxide
Overall Rating-Extensive based on variability and uncertainty in lexicological Review
Trichloroethane, 1,1,1-
RfD-Not listed Not scored ' Not scored
RfC-Not listed Not scored Not scored
Cancer- Minimal Minimal
Overall Rating-Minimal
Triethylene glycol monobutyl ether
B-6
-------
Appendix B - Independent Review of Assignments to Documentation Categories
.My 14,2000
Reviewer: Hugh Tilson
Chemical
RfD-Not listed
RfC-Not verifiable
Cancer-Not listed
Variability
Not scored
Minimal
Not scored
Uncertainty
Not scored
Minimal
Not scored
Overall Rating-Minimal
Trinitrobenzene, 1,3,5-
Overall Rating-Extensive on the basis of narrative for variability and uncertainty in the Support Document
Vanadium pentoxide t
RfD Minimal Minimal
RfC-Not listed Not scored Not scored
Cancer-Not listed . Not scored Not scored
Overall Rating-Minimal
Vinyl acetate
RfD-Not listed Not scored Not scored
RfC Moderate Minimal
Cancer-Not listed Not scored Not scored
Overall Rating-Moderate
Criteria for Classification:
Variability
Minimal No incidence generally
provided for RfD/RfC
Moderate Incidence, magnitude, onset
or duration mentioned with
some discussion, little discusion
about varability within or across
studies
Extensive Incidence, magnitude, onset
and duration mentioned
repeatedly; considerable discus-
sion about sources of variability
across and within studies
Uncertainty
Relatively terse description of what the
uncertainty factors were with little or
no discussion about their rationale;
no discussion about strengths or weaknesses
Rationale developed for the selection
of the uncertainty factors, strengths
or weaknesses mentioned
Considerable rationale for confidence
in studies and support provided for
conclusions, strengths or weaknesses
discussed
In some cases, assessments contained somewhat more documentation of uncertainties relative to
variability, and vice versa. If only one area qualified as Extensive, then the entire assessment was categorized as
Extensive. At the other end of the scale, if one part of an assessment contained Moderate documentation, the entire
assessment was categorized as Moderate. Several assessments were based on Supporting Documents or
lexicological Reviews located on IRIS. All of these were categorized as Extensive.
B-7
§
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