EMSL-LV-539-1                                     EMSL-LV-539-1
        >ll LEVELS IN COW'S MILK FOLLOWING INGESTION OF

            CONTAMINATED ALFALFA OR SUDAN GRASS
             S. C. Black, R. E. Stanley, and D.  S.  Earth


        Monitoring Systems Research and Development Division

           Environmental Monitoring and Support Laboratory

                U.S.  Environmental Protection Agency

                     Las Vegas,  Nevada 89114
                       Published August 1975
This research was performed as  a part of the Bio environmental Research
Program under Memorandum of Understanding No. AT(Z6-l)-539
                                for the
        U.S. Energy Research and Development Administration

-------
 This report was prepared as an account of work sponsored by the United
 States Government.  Neither the United States nor the United States
 Energy Research and Development Administration,  nor any of their
 employees,  nor any of their contractors, subcontractors, or their
 employees,  makes any warranty,  express or implied, or assumes any
 legal liability or responsibility for the accuracy,  completeness or
 usefulness of any information,  apparatus,  product or process disclosed,
 or represents that its use would not infringe privately-owned rights.
AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE
                   U. S.  DEPARTMENT OF COMMERCE
                       SPRINGFIELD,  VA  22161

          PRICE:  PAPER COPY  $4.00     MICROFICHE  $2.25

-------
  EMSL-LV-539-1                                     EMSL-LV-539-1
       1 ll LEVELS IN COW'S MILK FOLLOWING INGESTION OF

             CONTAMINATED ALFALFA OR SUDAN GRASS
             SV C.  Black, R.  E.  Stanley, and D/ S.  Earth


        Monitoring Systems  Research and Development Division

           Environmental Monitoring and Support Laboratory

                U.S. Environmental Protection Agency

                      Las Vegas, Nevada 89114
                       Published August 1975
This research was performed as a part of the Bioenvironmental Research
Program under Memorandum of Understanding No. AT(26-1) -539
                                for the
        U. S. Energy Research and Development Administration

-------
     Effective June 29, 1975, the National  Environmental  Research
Center-Las Vegas (NERC-LV) was designated the Environmental  Monitoring
and Support Laboratory-Las Vegas (EMSL-LV).   This Laboratory is one of
three Environmental Monitoring and Support Laboratories of the Office of
Monitoring and Technical Support in the U.S.  Environmental Protection
Agency's Office of Research and Development.

-------
                           ABSTRACT










A  dry aerosol,  consisting of submicrometer diatomaceous earth particles





tagged with    I,  was released over two different types of growing forage





(alfalfa and Sudan grass) at the Experimental Dairy Farm on the Nevada





Test Site.   Following deposition of the aerosol, the two forage types were





chopped and fed to different groups of lactating dairy cows.  The dual  ob-





jectives of the study were to evaluate  the relationship of    I secretion in





milk to the  ingestion of different types of contaminated forage and to ob-





tain a further indication of the possible influence on milk radioiodine





levels of changing the particle size of the contaminant.








The ratios ol the peak activity concentrations measured in the milk to the





peak activity concentrations in the forage were computed to be 0. 0145 for





the cows fed contaminated alfalfa and  0. 0082 for those fed contaminated





Sudan grass.  Comparison of the results from this study with those from





earlier studies  indicates the major effect on activity levels in the milk can





be related to forage type.   Ingestion of Sudan grass by the cow reduces the





transfer of  radioiodine to milk by one  half compared to ingestion of alfalfa.

-------
                  TABLE OF CONTENTS










                                                         Page





ABSTRACT	         i




LIST OF FIGURES	       iii




LIST OF TABLES	       iii







 I. INTRODUCTION	         1




 II. PROCEDURE	         3




III. RESULTS	         7





IV- DISCUSSION	        12




 V. CONCLUSIONS.	        16




REFERENCES	        17




APPENDICES	        18

-------
                     LIST OF FIGURES
                                                          Page
Figure 1.   Experimental plots and instrumentation
               for Project HARE	
Figure 2.   Concentration of     I in milk and forage
               for cows fed Sudan grass  and alfalfa ...     10

Figure 3.      I concentration in milk and total in
               alfalfa for metabolism cows	    11
                      LIST OF TABLES
Table 1.    Comparison of some Results from
               Previous Studies	
Table 2.    Milk Production and Feeding Regime
              for Cows Assigned to Project HARE  ....    6

Table 3.    Air  Sampler Data for Project HARE	    8

Table 4.    Summary of Parameters for Four Experiments   15
                          111

-------
                    I.  INTRODUCTION
In five previous experiments using various types of synthetic



aerosols the air-forage-cow milk system for    I transport has



been studied, giving particular attention to those parameters



which may be significant in determining the    I concentration in


     (1-5)
milk.      Many of the parameters in those experiments appeared



to follow a pattern with the exception of two important measure-



ments  obtained during Project Hayseed,    the  first experiment in



the series.   The peak milk to peak forage ratio (pCi/1: pCi/kg) for



Hayseed was less than the ratio measured in the other experiments



•where  a particulate aerosol was used and the percent recovered in



milk was smaller. *  '  '  A  comparison of some of the measurements


obtained during these experiments is shown in  Table 1.

-------
Table 1 - Comparison of Some Results from Previous Studies
Parameter
Total 131I Released (mCi)
Count Median Diameter of Aerosol
Deposition ((J-Ci/m )
i Q 1
I Integrated Air Concentration
((j-Ci-sec/m )
Wind Speed (km/h)
Ambient Temperature (°F)
Relative Humidity (%)
Type of Forage Fed
Peak Forage Level ([iCi/kg)
Peak Milk Level (nCi/1)
Milk/ Forage Ratio
Percent Recovered in Milk
Hayseed
22
23
3. 13
322
4.83
51
35
Sudan
2.7
22
0. 0081
2. 1
Alfalfa
40
2
4. 66
333
2.22
58
40
Alfalfa
3.4
109
0. 032
12. 5
SIP
52
0. 13
1.63
157 '
4.83
39
59
Alfalfa
1. 1
70
0. 062
7.6
An examination of the various parameters listed in Table 1 indicated two




possible causes for the large variation in the milk/forage ratio and per-





cent in milk among these experiments.  These  causes are the different




count median diameter (CMD) of the aerosols used and the different types





of forage used.  Other factors,  acting singly or in concert, may contribute




to the observed variation in the milk/forage ratio.  However, their con-




tributions are not as  obvious, from these data, as are the differences in




the CMD of the aerosols and the forage types.

-------
Since it was impossible to attribute the difference between the two experi-




ments solely to one of the possible causes,  a new experiment was  con-




ducted to resolve the problem.  The experiment, described herein, was




called Project HARE (for Hayseed-Alfalfa Repeat Experiment).  The ex-




perimental procedure included the release of a dry aerosol of a known




particle  size (0. 13 
-------
                             10m
          OB
         DB
                                        TD
                                        10m  .
DB
OB
A
B B B


om nm t a o
9
bbm
*
D

A
B
• • • • •
0 B B

*
B O DB OB
4 *
* lunfr 55m
t
16m


1


3m
Sudan Grass
                                                                  Alfalfa
DOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

                                                                          5.5m
                 •  Cascade Impactor
                 A  Filter Pack
                 ±  Planchet Rack
                 B  Glass Slide
                 O  Fallout Tray
                                 O Tempest
                                  • Planchet
                                 O Generator
                                 D DAT Trailer
                                        Figure 1
                        Experimental forage plots and instrumentation

-------
The lactating cows in the dairy herd were divided into four groups and


fed chopped fresh forage  (green-chop) according to the schedule shown in


Table 2.  The amount of forage obtained with one pass of the chopper


through each contaminated plot was divided into thirds for each cow group.


Each experimental cow was then offered a measured amount of contaminated


forage, chopped fresh daily, and any residue was weighed to determine the


quantity actually consumed.  Grain and uncontaminated forage were used to


supply the balance of the  cows' ration.  All of the cows except those assigned


to Group IV were  milked twice daily and the milk analyzed for    I.  The


Group  IV  cows were used in a  special metabolism experiment.   The sampling


and analytical procedures are  included in the previous reports. '  ~  '
Subplots in the plots of Sudan grass and alfalfa were used to determine the


effective half-life (Te££) of    I on the two types of forage.  The subplots


were divided into 70 sections and randomly selected sections sampled.  Each

                                                   T
sample consisted of all the forage  cut from a 0. 075m  circle in the selected


section.  This  sampling was continued for 20 days post-release.
The samples were gamma counted on a system consisting of a Nal (TI)


crystal and 200-channel analyzer.  The     I activity in the samples  was


determined by computer analysis  of the gamma spectra obtained from


counting.

-------
Table 2.  Milk Production and Feeding Regime for Cows Assigned
            to Project HARE.

Group
No. Cow
16
45
I 47
2
II 13
39
21, 27
III 43,46
84, 85
87
35
IV 36
62
Daily
Milk
Production
(liters)
29.9
22. 0
23.3
18.4
29.9
22. 0

23.7
18.4
16.4
Group
Average
Daily
Milk
Production
(liters)
25. 1
23.4

21.4
19. 5
Daily
Feed
Con-
Type sumption
of Forage (kg)
Contaminated
Sudan 1 0
Contaminated
Alfalfa 10

Uncontaminated
Alfalfa
Contaminated
Alfalfa 20

Remarks
Feed gradually
increased to 20kg.
(Fed uncontamina-
ted Sudan grass for
4 days prior to re-
lease)
Feed gradually
increased to 20kg.

Control group.
Fed only uncontam-
inated forage
Metabolism group.
Fed 10 kg twice
daily. Last two days,
fed 20kg twice daily.

-------
                            III.  RESULTS


The average deposition on the Sudan grass, as estimated from the deposi-


tion on 35 planchets, was 1. 25 fiCi/m  .  The average deposition on the

                                             O
alfalfa, similarly estimated, was  1.43 uCi/m .  From these data,  it was


then estimated that 4. 7% of the activity released was deposited on the test


plots.   The air  sampler data in Table  3 indicate an average integrated air



concentration of 87. 5p.Ci-sec/m   with a prefilter to charcoal  activity ratio


of 1. 08.  The average  deposition velocity as calculated from planchet data


adjacent to  the air samplers was 1. 6 cm/sec.
Approximately 500 particles  on each of 19 glass  slides were sized, using


the Feret diameter measurement.  These data indicated a 0. 64 |am count


median diameter for the aerosol deposited on the test plots.





The average wind speed during the aerosol release was 4. 5 km/h,  from


326° true, with a temperature of 51°F and a relative humidity of 51%.





The analysis of milk from control cows (Group III) and of water,  grain,


and uncontaminated forage fed to all groups indicated that the deliberately


contaminated forage was the  only significant source of    I in the experi-


mental cow groups.
The peak    I activity concentration in the Sudan forage was  5. 75 nCi/kg,

-------
   Table 3.   Air Sampler Data for Project HARE.
                                                             Integrated
                                                                Air
Sampler  Whatman  Charcoal  Microsorban Total  Whatman   Concen-    Deposition
Number*     nCi       nCi        nCi        nCi   Charcoal   tration     Velocity
                                                    Ratio    (J-Ci-sec/m     cm/sec
1 349
2 166
3 178
4 249
5 201
6 237
7 29.2
8 291
9 169
363
208
242
202
171
219
77.8
117
192
00.
02.
03.
02.
02.
02.
00.
00.
03.
925
91
58
30
81
20
949
724
29
713
377
424
453
375
458
108
409
364
Average
0.
0.
0.
1.
1.
1.
0.
2.
0.
1.
961
798
735
23
18
08
375
49
880
08
161
82.
86.
98.
76.
93.
22.
92.
74.
87-

0
9
5
8
8
1
1
6
5
0.
1.
2.
1.
2.
1.
2.
1.
1.
1.
86
4
1
4
3
3
1
2
7
6
   *In Fig.  1, air samplers  were numbered left to right and front to rear starting
    from the side of the plots nearest the generators.

-------
measured on the first feeding offered the Group I cows following the re-




lease (Appendix 1-3).  The effective half-life for the    I in the Sudan over




the 8-day feeding period was 4. 1 _ 0. 14 days. With a measured peak milk




activity concentration of 47. 1 nCi/liter, the calculated milk to forage ratio




for Group I was 0. 0082.  Similar measurements and calculations on the




feed and milk of the Group II cows (fed contaminated alfalfa) gave a peak





forage activity concentration of 2. 28 nCi/kg,  an effective half-life in the




forage of 6. 8 Z 0. 73 days, an initial peak milk activity concentration of




32. 8 nCi/liter,  and a milk to forage ratio of 0. 0145 (approximately 2 times




greater than that  for Group I).  The initial peak concentration in milk oc-




curred at 1. 25 days in both groups.  A second peak activity of 52. 6 nCi/liter




occurred at 6. 25  days in the  group fed contaminated alfalfa.  The effective




half-lives of    I in milk after the cows'  rations were changed to uncon-




taminated feed were  0. 85 and 0. 74 days,  respectively, for the groups fed




Sudan grass or alfalfa.  The  *-'•'• I activity ingested with the forage and the




concentration secreted in the milk of the  cows in Group I and II are shown




in Figure 2 and Appendices 1-1, 1-2 and 1-3.  Similar  data for the meta-




bolism cows (Group IV) are shown in Figure 3 and Appendices  1-3 and  1-4.

-------
   100
10
                       \/\.
                        •\/\
                                          MILK
b
    1.0
                                   V-
                          FORAGE
                                                   CO
                                                   LLJ
                                                   CO
                                           '4
                                         \   -   A
                                               .      •
                                               \/\/\
                                                         200

                                                         100

                                                         50
0.1
       0124     6     8     10     12     14
                    DAYS AFTER INITIAL FEEDING
                                                   16
                                                              10
          i-  2.
                    i concentration in milk from cows fed
                 Sudan grass (•-•) or alfalfa (A A) and total
                 iodine-131 ingested with Sudan grass (o-o)
                 or alfalfa (A A).
                               10

-------
    10
          l\ J
                                  V
                                    \

    10
£   10
                               \ <+- MILK
                                \
\
                             FORAGE
                                           \
                                              \
                                                V,
             \  S~
200
100
      -i
    10
i   i   i   i   i   i   i   i   i
                               1
1   1   1   1    I   1
   12     4     6      8     10     12    14
               DAYS AFTER INITIAL FEEDING
                                                          16
10
          Fig. 3.   Average     I concentration in milk (
                   and total ingested with alfalfa  green
                   chop (o-o) for the metabolism  cows.
                                 11

-------
                        IV-  DISCUSSION

Changing weather introduced an element of complexity in this study.

Tests on the crops  prior to the experiment indicated that one swath

through the  experimental plots by the chopper would provide 10 kg/day

for each of the three cows in the groups; however, warm weather occur-

ing after the start of the experiment increased the yield to 20 kg/day per

cow even though the plots were not irrigated during that period.  The prin-

cipal  effect  of this increased feed was a positive slope in the     I concen-

tration in milk during  feeding of the cows  fed alfalfa green chop  (Figure 2).

For the cows fed Sudan grass, the effective half-life for iodine-131 in milk

during feeding  was  about 4 days rather than 3  days noted during the Hayseed

experiment, possibly  a result of the increasing amounts fed.



The results of this  experiment, though, indicate that radioiodine is not

secreted in milk to the same extent when cows are fed Sudan grass as when

they are fed alfalfa.  There are three observations that  confirm  this con-

clusion.   First,  even  though the total intake was smaller with the alfalfa

feed (Figure 2),  the iodine-131 in milk was higher than with Sudan grass

feeding.   Secondly, using only the first peak concentration in milk after

start  of feeding,  the ratio of peak concentration in milk  to peak forage con-

centration was 0. 0082 for the Sudan grass feeding and 0. 0145 for the  alfalfa

feeding,  almost 2 times higher.  Thirdly, the percent of ingested iodine-131

secreted in  milk was  only 3. 6 for the cows fed Sudan grass while it was 7. 2

for the cows fed  alfalfa, in agreement with the milk/forage ratios.
                                                            1

                                  12

-------
The data for the metabolism cows (Group IV, alfalfa feed) shown in





Appendices 1-3 and 1-4 indicate a milk/forage  ratio of 0. 029 and a per-





cent in milk of 6. 2.  These data agree with the Group II data.   The milk/





forage ratio was twice  that for Group II,  because the Group IV cows in-





gested double the amount of feed that  Group II ingested.










A  similar study conducted by another laboratory     showed that feeding





Sudan grass to cows after oral doses  of radioiodine decreased the percent





of radioiodine transferred to milk by  half compared to feeding bromegrass.





Those authors  suggest  some chemical compound in the Sudan grass affected





the mammary gland, and that the nitrate and cyanide constituents were not





the responsible agents.  A milk/forage ratio could not be calculated from





that report,  because oral dosing was  used.  The decreased percentage ex-





cretion,  though, confirms the results reported herein.










A  change in milk production rate may be excluded as a cause of decreased





iodine-131 secretion in this study.   The Group  I cows (Sudan grass) aver-





aged 25. 8 liters/day compared  to 25. 1 for the month before the experiment





while Group II  cows (alfalfa) averaged 21.5 liters/day during the experiment





as compared to a prior 23. 4 liters/day.










Selected parameters summarized from the results of four different studies,





in which    I-labeled DE was used to contaminate  growing forage, are





shown in Table 4.   In both instances where Sudan grass was the source of







                                 13

-------
iodine-131,  the milk to forage ratio and the percent secreted in milk -was




less than in the three experiments where alfalfa was used as forage.










There are two apparent anomalies in Table 4, the relatively low deposition





velocity measured for the Hayseed experiment and the high percent secreted





in milk in the Alfalfa experiment.  However, the diatomaceous earth used as





the carrier aerosol  in these experiments has a relatively low bulk density




because  of the porous  nature of the material so the CMD  of 23[J.m measured




for Hayseed would indicate  an average surface area about 120 times that for





the aerosol used for Alfalfa.  It was therefore probable that air bouyancy




lowered  the deposition velocity.   Furthermore,  one of the four cows used




in the Alfalfa experiment consistently secreted 20-30% of ingested radio-




iodine in her milk in various experiments and secreted 24% during Alfalfa




while the average for the other three cows in that group was only 8. 7%.










It is probable that the  factor of two difference in the secretion of iodine-131




into milk is a minimum difference as  a relatively simple correction of the




milk secretion curves for a consistent amount of forage intake (rather than




the increasing amount of  intake that occurred) suggests a factor  of three





difference.  This  difference in the milk/forage ratio can  also be obtained if




the highest milk concentration in  the cows  fed alfalfa is used,  i. e. , 0. 0526




HCi/liter -f 2. 28  M-Ci/kg is  0. 023  versus the 0. 0082 for the  Sudan grass group,
                                  14

-------
Table 4. Summary of Parameters for Four Experiments with particulate aerosols^
Experiment
HARE

Hayseed
Alfalfa
SIP
Aerosol
CMD (|xm)
0. 64

23
2
0. 13
Average
Deposition
(fJ-Ci/m2)
1.25
1.43
3. 13
4.66
1. 63
Deposition
Velocity
(cm/ sec)
1.6
1.6
1. 3
2.4
0. 92
Type of
Forage
Sudan
Alfalfa
Sudan
Alfalfa
Alfalfa
Peak
Forage
(M-Ci/kg)
5.74
2. 28
2.7
3.4
1. 13
Peak
Milk
([iCi/liter)
0. 0471
0. 033
0. 022
0. 109
0. 0695
Milk/
Forage
Ratio
0. 0082
0. 014
0. 0081
0. 032
0. 062
Percent
in Milk
3.6
7. 2
2.
12. 5
7. 5
KMilk data based on cows fed fresh green-chop daily.

-------
                           CONCLUSIONS







     Based on the conditions of this experiment, the following conclusions





may be derived from the results.







     1.  Cows fed     I-contaminated Sudan grass secrete half as much of




the iodine in their milk as do cows fed similarly contaminated alfalfa.







     2.  Both the ratio of peak concentration in milk to peak concentration





in ingested forage and the total percent recovered in milk in 16 days are




reduced by half if Sudan grass rather than alfalfa is the  source of radio-




iodine.







     3.  The  cause of this effect of Sudan grass on milk secretion of iodine




is speculative  at this time.  There are  several possibilities, e.g., com-




parative digestibility of the forages, chemical binding of the iodine, and




chemical blocking of the mammary secretory process are likely candidates.







     4.  The  particle size of the    I-labeled aerosols used in these experi-




ments appears to  exert  some influence  on the milk/forage ratio, but its




effect is not  as conclusive as is the species of forage.
                                  16

-------
                           REFERENCES
1.   Black S.C.,  Earth D.S. and Engel R. E. ,  13 4 Dairy Cow Uptake
    Study Using a Synthetic Dry Aerosol (Hayseed) Southwestern Radio-
    logical Health Lab. ,  Las Vegas, NV, (Unpublished memorandum
    report) Summary report by D.S. Barth and M.S.  Seal in Proceed-
    ings of Symposium on Radioecological Concentration Processes,
    Stockholm, Sweden (April 1966).

2.   Stanley R.E. ,  Black S. C. and Barth D.S. ,  131I Dairy Cow Uptake
    Studies Using a Dry Aerosol (Alfalfa), Southwestern Radiological
    Health Lab.,  Las Vegas, NV Report  SWRHL-4Zr (1969).

3.   Mason B. J. ,  Black S. C. and Barth D.S. , 131I Dairy Cow Uptake
    Studies Using a Submicrometer Synthetic Dry  Aerosol (SIP) South-
    western Radiological Health Lab. , Las Vegas, NV Report SWRHL-
    39r (1971).

4.   Douglas R. L. ,  Black S. C.  and Barth D. S. ,  131I Transport through
    the Air-Forage-Cow-Milk System Using an Aerosol Mist (Rainout),
    Southwestern Radiological Health Lab. ,  Las Vegas, NV  Report
    SWRHL-43r  (1971).

5.   Douglas  R. L. ,  Black S. C.  and Barth D. S. ,  13 h Transport through
    the Air-Forage-Cow-Milk System Using Molecular Iodine (MICE"),
    Southwestern Radiological Health Lab. ,  Las Vegas, NV  (in review).

6.   James R.H., McNelis D. N. , Whittaker E. L.  and Kennedy N. C. ,
    Aerosol Preparation, Generation and Assessment-Project HARE,
    Southwestern Radiological Health Lab. ,  Las Vegas, NV  Report
    SWRHL-75r  (1970).

7.   Moss B. R. ,  Voilleque P. G. , Moody E. L. ,  Adams D. R. ,
    Pelletier  C. A.  and Hoss D. ,  Effects  of Feeding Sudan grass on Iodine
    Metabolism of Lactating Dairy Cows, J. Dairy Sci. 55,  1487-91 (1972).
                                  17

-------
Appendix 1-1.
                131
I Concentration in Milk,  Cows fed Sudan grass (Group I)
            Cow 16
           Cow 45
Cow 47
Weighted Average
Time*
0.27
0.93
1. 27
1.94
2. 27
2.95
3. 28
3.96
4. 27
4.97
5.28
5.92
6.29
6. 94
7. 29
7. 94
8. 27
8. 95
9. 28
9.94
10. 29
10. 94
11.29
11.93
12. 29
12. 93
13. 3
13.94
14. 28
15. 06
15. 28
15.94
nCi/liter
55.7
42.6
62.3
34.9
39.7
24.0
34.6
23.2
26.9
19.7
23. 2
17. 0
20. 5
12. 1
19.3
13. 1
10.3
4.9
3. 5
1.7
1.4
0.64
0.71
0.39
0.44
0.32
0.26
0. 15
0.22
0.27
0.22
0. 18
liters
13.6
20. 2
11.4
18. 9
11. 0
21. 9
10. 5
21. 1
10. 5
20.2
11.4
17. 1
13. 6
18.4
9.7
19. 8
13. 2
16. 2
11. 0
18. 0
11.4
19. 3
11. 0
21. 9
11.9
21. 9
11.4
18. 0
11.0
19.3
7.9
18.4
nCi/liter
33.4
26.9
32. 2
19.2
20.2
14. 1
18.9
12. 0
20. 8
12.4
11.9
9.3
12. 7
6.6
11. 2
6.5
6. 1
2. 3
1. 7
0. 78
0. 82
0.42
0. 55
0. 30
0.30
0. 24
0. 28
0. 19
0. 21
0. 24
0. 23
0. 23
liters
8.8
14.9
9.2
13.2
7.0
13.6
9.2
13.6
7. 0
14.9
7.9
14. 0
7. 9
13. 2
8.8
13. 2
7. 5
12. 7
7. 0
13.6
6. 1
11.9
7.9
11.9
6.6
11. 0
6. 1
11.4
4. 0
13.6
5.3
11. 0
nCi/liter
37-6
41. 1
44.4
31.3
43.3
22.8
29.2
23. 5
31.0
25. 5
20. 5
17. 1
17. 0
13. 1
17. 0
13. 5
12. 1
7. 2
5. 5
3.3
2.7
1. 5
1.4
0.99
0.79
0.49
0. 50
0.35
0.45
0. 15
0. 53
0.37
liters
12. 7
14. 5
12.7
18. 0
9.7
16.7
14. 0
14. 5
10. 0
15.4
9.2
18. 0
10. 1
15. 8
11.4
15. 8
8.8
15.8
8. 3
14. 5
11. 0
14. 0
10. 5
15. 8
9.2
16.2
11. 0
15. 8
10. 5
14.9
8.8
14. 5
nCi/liter
43. 5
37.4
47. 1
29.4
36. 0
21. 0
28. 0
20. 1
26.9
19.3
19. 1
14. 8
17.4
10. 9
16. 0
11.4
9. 8
5. 0
3.6
1. 9
1. 8
0. 84
0. 93
0. 56
0. 52
0. 36
0. 36
0. 23
0. 32
0.22
0. 34
0.26
                                              Total in Milk   16. 5
  * Days after initial feeding.
                                   18

-------
Appendix 1 -2.
                 131
I Concentration in Milk,  Cows fed Alfalfa (Group II)
             Cow 2
           Cow 13
Cow 39
Weighted Average
Time*
0.26
0. 92
1. 28
1. 93
2. 26
2. 94
3.26
3. 94
4. 26
4. 94
5.26
5.91
6. 28
6. 92
7. 28
7. 94
8.27
8. 95
9.28
9. 94
10.29
10. 94
11.29
11.93
12. 29
12. 93
13. 30
13. 94
14. 28
15.06
15.28
15.94
nCi/liter
33.3
29. 1
29.8
17.8
23.4
16. 1
36.9
26.7
37.0
23. 1
34. 0
23. 1
35.4
32. 0
37.9
29.2
21. 1
9.8
6.4
2. 3
1.7
0. 96
0.74
0.43
0.42
0. 38
0.28
0.21
0.28
0.23
0.29
0. 19
liters
6.6
12.7
7. 5
12.7
6.6
13.6
6.6
13. 6
5. 7
14. 0
6. 1
10. 5
7. 0
12. 3
7. 5
11.4
5. 3
12. 3
7. 0
10. 5
4. 8
12.3
6. 6
12. 3
5. 7
14. 0
7. 0
10. 1
6. 1
12. 7
4. 8
11.9
nCi/ liter
18.9
20.4
20. 1
12. 1
12.9
11.9
23.2
19. 1
32.9
26.2
26. 0
16. 5
31. 1
22.7
23.8
17. 9
14. 0
7.9
5.6
3.3
3. 0
1.6
1.3
1. 0
0. 82
0. 61
0.44
0. 32
0. 29
0.20
0. 25
0.26
liters
15.8
22.4
13.2
19.8
12.7
22.8
12.7
25. 5
12.3
20.2
12.7
19.8
12.7
20. 6
12. 3
21.9
U. 0
19. 8
12. 7
19. 8
10. 1
20. 2
7-0
16.7
6.6
21. 1
7.9
17. 1
9.7
20. 6
6. 1
19. 8
nCi/liter
51. 0
51. 0
56.0
30.2
33. 1
31.4
74. 1
47.6
90. 8
48. 5
81.8
45.7
91.7
45.9
65.4
47. 9
29.9
13. 5
8.8
3.8
2.9
2. 0
2.4
1.2
1.3
0. 89
1.2
0. 80
1. 0
0.81
1. 2
0.84
liters
9.7
14. 9
8.3
15.8
8.8
15.8
9.7
17. 6
7. 9
15.8
9.2
14. 9
10. 1
15.4
8. 8
14. 9
8. 8
14. 0
8. 8
15.4
6.6
15.4
7.9
14.9
8. 8
18.4
7.9
14. 0
9.7
16.7
6.6
14. 9
nCi /liter
31. 5
31. 7
32. 8
19. 5
21. 6
18. 8
43.3
29.7
51.4
32. 3
46. 0
27- 6
52. 6
32.4
40. 2
29.8
21. 0
10. 0
6.8
3. 3
2. 7
1.6
1. 5
0. 93
0. 90
0. 64
0. 65
0.46
0. 56
0.41
0. 60
0.42
                                               Total in Milk   21. 9 |JtCi
   *Days  after initial feeding.
                                     19

-------
   Appendix 1 -3.
                  131
           I in Cow Feed
Time
hours
  0
 23
 47
 71
 95
 119
 142
 166
   0
 23
 47
 71
 95
119
142
166
10
12
11.
18
19
20
19
19
       nCi/kg
             Cow 16
10
12
15
20
20
20
20
20
7.78
1. 32
1. 10
0.85
0.45
0.84
0. 55
0.44
              Cow 2
2.73
0. 60
0.93
0.92
0.76
0.65
0.46
0.49
                nCi/kg
kg     nCi/kg
                          Group I - Sudan grass
Cow
9.5
12
15
20
20
20
20
20
45
4.95
1.42
0. 88
1. 04
0. 56
0. 65
0.44
0. 51
Cow
10
8. 3
9.3
18
18
18
18
18
47
4.47
1.78
1.0
1.21
1. 16
0. 72
0. 52
0. 59
Total Intake
Group II
Cow
9.8
12
12
20
19
19
20
19
- Alfalfa
13
2. 52
0.75
0.91
0.94
0.84
0. 33
0. 52
0. 35

Cow
9.7
12
13.8
20
20
20
20
20

39
2. 11
0. 67
1. 07
0.49
0.69
0.70
0. 55
0.38
Daily Intake
   M-Ci
                    16. 90
                    47. 6
                    38. 9
                    59. 5
                    41. 1
                    42. 7
                    29. 1
                    29.6
                                                                458
                   67.4
                   24. 1
                   36.3
                   45. 0
                   44. 1
                   33.3
                   30. 0
                   23. 5
                                             Total Intake
                                                      304
                                 20

-------
   Appendix 1-3.
                   131
     I in Cow Feed - Cont'd
Time
hours
  0
 25
 18. 6
 22.7
 42. 9
 48.9
 67.4
 72. 9
 92.4
 98.2
115.6
118.8
138.8
144. 3
163.8
167. 3
nCi/kg
nCi/kg
kg
nCi/kg
                        Group IV (Metabolism) - Alfalfa
Cow
10
10
10
10
12
12.4
12
12
11. 5
11. 5
9
9
20
20
20
20
35
3.23
3.31
0.84
0.93
0. 97
0.78
0.88
0.85
0.76
0.85
0.86
0.76
0.72
0. 54
0, 53
0. 58
Cow
10
10
10
10
11.6
11.6
11. 5
11. 5
10. 5
10. 5
10. 5
10. 5
20
20
20
20
36
2.78
2. 80
1.07
0. 94
0.70
0.72
0.86
0. 96
0. 93
0. 94
0. 92
0.93
0.49
0. 65
0. 56
0. 52
Cow
9.3
10
9.2
10
7.7
12. 1
10
10
10. 5
10. 5
8. 5
8. 5
20
20
20
20
62
2. 51
1.93
1.25
0.82
0.92
0.84
0.85
0.92
0.79
0.98
0.89
0.74
0.81
0.84
0. 67
0.41
Daily Intake
   p-Ci
                                                 164

                                                  58.2

                                                  54.9

                                                  59.2

                                                  56. 8

                                                  47.8

                                                  80.7

                                                  64.8
                                                Total Intake
                                                 585 [J.Ci
                                  21

-------
               131
Appendix 1-4.     I Concentration in Milk, Cows fed Alfalfa (Group IV)
        Cow 35
Cow 36
Cow 62
Weighted Avg.
Time*
0. 1
0.76
1. 10
1.76
2. 10
2.76
3. 10
3.76
4. 08
4.82
5. 10
5. 82
6. 11
6. 80
7. 10
7. 82
8. 10
8. 82
9. 10
9.76
10. 10
10.72
11. 10
11.72
12. 01
12. 72
13. 10
13.72
14. 10
14. 72
15. 10
15. 72
nCi /liter
10. 1
73.7
69.8
46.2
99.6
89.6
68. 5
121
93.5
77.4
80.2
65.7
75. 0
80.6
86.3
63. 1
52. 1
29. 5
20.8
15.3
7. 0
3. 5
3. 1
1.3
1. 5
0.92
1.4
0.64
0.87
0.79
1. 1
0.82
Liters
4.2
10. 5
8.6
16. 1
7.4
9. 1
3. 0
10.4
3. 8
10. 1
4. 5
10. 1
5. 0
10. 2
5.4
11. 0
4. 3
10. 0
4. 5
11. 0
5. 3
12. 3
6. 6
13. 2
9.7
13.2
7. 0
12. 3
5. 3
13. 6
4.4
11.9
nCi/ liter
16.3
100
95.8
74.0
70.4
77.7
98.3
104
-
118
142
126
160
143
128
107
96.7
54.3
48. 0
28. 0
14.0
9.7
7. 3
3.4
3. 1
1.6
1.8
1. 1
1. 1
1.3
1.3
0.80
Liters
4.8
10. 9
7.8
15.4
8.8
1.3
5. 0
11.3
-
12. 0
5. 0
10.2
4.0
11. 0
5. 1
11. 2
4. 5
11.0
5. 0
11.4
7- 0
11.9
7.9
12.7
6.6
13.2
6.6
11.9
7.9
13.2
5.7
11.9
nCi /liter
9.7 '
62.3
54. 5
48.6
41. 5
64.4
61.7
77.7
110
115
115
91.6
103
105
105
89.7
87.4
53. 0
_
30.9
21. 7
10.3
8.6
5. 1
2.8
2.3
2.0
1.2
1.6
1.0
1. 5
0.76
Liters
4. 0
10.2
4.9
13. 2
4. 3
10. 8
3. 1
10. 0
2.7
9. 5
3.2
11. 0
4.2
11. 5
4.7
10.8
4. 0
10. 5
—
11.9
5.7
13.2
5. 7
13. 2
6. 1
11.4
7. 9
11. 9
7. 5
13. 2
4. 8
12.7
nCi/liter
12.2
79. 1
52.4
58.0
74.8
76. 0
79.9
100. 8
98.8
104
113
94. 0
110
110
103
86.4
78. 8
46. 0
35. 1
24. 9
14. 3
7. 8
6. 3
3. 3
2. 3
1. 6
1 7
J. • 1
0. 98
1. 2
1. 0
1. 3
0. 79
                                   Total in Milk   36. 5
                              22

-------
                               DISTRIBUTION

 1  - 20  Environmental  Monitoring and  Support  Laboratory, Las Vegas, NV
     21  Mahlon E. Gates, Manager, ERDA/NV, Las Vegas, NV
     22  Robert H. Thalgott, ERDA/NV, Las Vegas, NV
     23  Bennie G. DiBona, ERDA/NV, Las Vegas, NV
     24  David G. Jackson, ERDA/NV, Las Vegas, NV
     25  Arthur J. Whitman, ERDA/NV, Las Vegas, NV
     26  Elwood M. Douthett, ERDA/NV, Las Vegas, NV
27 - 28  Paul B. Dunaway, ERDA/NV, Las Vegas, NV
29 - 30  Ernest D. Campbell, ERDA/NV, Las Vegas, NV
31  - 32  Mary G. White, ERDA/NV, Las Vegas, NV
     33  Roger Ray, ERDA/NV, Las Vegas, NV
     34  Robert W. Taft, ERDA/NV, Las Vegas, NV
     35  Leon Silverstrom, ERDA/NV, Las Vegas, NV
     36  Richard C. Amick, ERDA/NV, Las Vegas, NV
     37  John 0. Cummings, ERDA/NV, Las Vegas, NV
     38  Bruce W. Church, ERDA/NV, Las Vegas, NV
39 - 40  Technical Library, ERDA/NV, Las Vegas, NV
     41  Chief, NOB/DNA, ERDA/NV, Las Vegas, NV
     42  Martin B. Biles, DOS, ERDA, Washington, DC
     43  Tommy F. McCraw, DOS, ERDA, Washington, DC
     44  Major General  Ernest Graves, Dir., DMA, ERDA, Washington, DC
     45  Assistant General Manager, DMA, ERDA, Washington,  DC
     46  Gordon C. Facer, DMA, ERDA, Washington, DC
     47  James L. Liverman, Dir., DBER, ERDA, Washington, DC
     48  Robert L. Watters, DBER, ERDA, Washington, DC
     49  John S. Kirby-Smith, DBER, ERDA, Washington, DC
     50  L. Joe Deal, DOS, ERDA, Washington, DC
     51  Charles L. Osterberg, DBER, ERDA, Washington, DC
     52  Rudolf J. Engelmann, DBER, ERDA, Washington, DC
     53  Harold F. Mueller, ARL, NOAA, Las Vegas, NV

-------
     54  Gilbert J.  Ferber,  ARL,  NOAA,  Silver Spring,  MD
     55  Wilson K. Talley, Assistant  Administrator for Research  and
         Development,  EPA, Washington,  DC
     56  William D.  Rowe,  Deputy  Assistant  Administrator  for Radiation
         Programs,  EPA,  Washington, DC
     57  William A.  Mills, Dir.,  Div. of Criteria  and  Standards,
         ORP,  EPA, Washington,  DC
58 - 59  Floyd L. Galpin,  Dir., Field Operations  Div., ORP,  EPA,
         Washington, DC
     60  E.  David Harward, Dir.,  Div.,  Technology  Assessment, ORP,
         EPA,  Washington,  DC
     61  Joan  A. Davenport,  Dir., Office of Technical  Analysis,
         EPA,  Washington,  DC
     62  Library, EPA, Washington, DC
     63  Bernd Kahn, Chief,  Radiochemistry  and Nuclear Engineering,
         EPA,  NERC-Cincinnati,  OH
     64  Peter Halpin, Chief, APTIC,  EPA, Research Triangle  Park, NC
     65  Paul  DeFalco, Jr.,  Regional  Admin., Region IX, EPA
         San Francisco,  CA
     66  James K. Channell,  Regional  Radiation Representative,
         Region IX,  EPA, San Francisco, CA
     67  Charles R.  Porter,  Dir., Eastern Environmental Radiation
         Facility,  EPA,  Montgomery, AL
     68  K.  M. Oswald, Mgr., Health and Safety, ILL, Mercury, NV
     69  Bernard W.  Shore,  LLL,  Livermore,  CA
     70  James E. Carothers, LLL, Livermore, CA
     71  Howard W.  Tewes,  LLL,  Livermore, CA
     72  Lawrence S. Germain,  LLL, Livermore, CA
     73  Paul  L. Phelps, LLL,  Livermore, CA
     74  Mortimer L. Mendelsohn,  LLL, Livermore,  CA
     75  Charles I.  Browne,  LASL, Los Alamos, NM
     76  George E.  Tucker, Sandia Laboratories, Albuquerque, NM
     77  Harry S. Jordan,  LASL,  Los Alamos, NM
     78  Arden E. Bicker,  REECo,  Mercury, NV
     79  Savino W.  Cavender, REECo, Mercury, NV
     80  Carter D.  Broyles,  Sandia Laboratories,  Albuquerque, NM
     81  Melvin L. Merritt,  Sandia Laboratories,  Albuquerque, NM
     82  Richard S.  Davidson,  Battelle  Memorial Institute, Columbus, OH

-------
      83  Steven V. Kaye, Oak Ridge National Lab., Oak Ridge,  TN
      84  Leo K. Bustad, College of Veterinary Medicine,  Washington
          State University, Pullman, WA
      85  Leonard A. Sagan, Palo Alto Medical Clinic, Palo Alto, CA
      86  Vincent Schultz, Washington State University, Pullman, WA
      87  Arthur Wallace, University of California, Los Angeles, CA
      88  Wesley E. Niles, University of Nevada, Las Vegas, NV
      89  Robert C. Pendleton, University of Utah, Salt Lake,  UT
      90  William S. Twenhofel, U.S. Geological Survey, Denver, CO
      91  Paul R. Fenske, Desert Research Institute, University of
          Nevada, Reno, NV
      92  President, Desert Research Institute, University of  Nevada,
          Reno, NV
93 - 119  Technical Information Center, ERDA, Oak Ridge,  TN
          (for public availability)
     120  Verle- R. Bohman, University of Nevada, Reno, NV
     121  Manager, Desert National Wildlife Range, U.S. Fish and
          Wildlife Service, Las Vegas, NV
     122  Supervisor, Region III, Nevada Fish and Game Department
          Las Vegas, NV
     123  Paul Lyons, Nevada Wildlife Research, Division of Archives,
          Capitol Building Annex, Carson City, NV

-------