CYCLING OF XENOBIOTICS THROUGH MARINE AND

           ESTUARINE SEDIMENTS
      Extracted from cited papers by

            Charles N. .D'Asaro
          Department of Biology
        University of West Florida
          GRANT NO. R804458
            Project Officer

            Frank G. Hi Ikes
   Environmental Research Laboratory
  U.S. Environmental Protection Agency
        Gulf Breeze, Florida"32561
   ENVIRONMENTAL RESEARCH LABORATORY
  OfFICE-OF RESEARCH AND DEVELOPMENT
 II.S. -ENVIRONMENTAL PROTECTION'AGENCY
                            SZ 561

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                                   CONTENTS
Abstract 	
Figures  	
  1.  Introduction 	
  2.  Cycling of Xenobiotics by the Lugworm,  Arenicola cristata .
      a.  Bentic Photo-Bioassay System 	
      b.  Cycling of Methyl  Parathion by Lugworms  	
      c.  Effect of sodium Pentachlorophenate on Lugworm Activity
      d.  Uptake and Depuration of Chrysene by Lugworms  	
  3.  Toxic Sediment Bioassay System
      a.  Methods Development v/ith Kepone-Sorbed Sediment  .  .  . .
      b.  Tests with Dredge Spoil	
      c.  Tests with Drilling Mud  	
  4.  Predator-Prey Tests
      a.  One and Two-Prey Tests with Separate Controls  	
      b.  Exposed and Control Prey in the Same System	,
      c.  Cryptic Shading and Predation  	 .
  5.  Evaluation of Sublethal Effects in Special Test Systems.  . ,
      a.  Avoidance of Pollution Gradients 	
      b.  Toxicant Induced Changes in Cyclic Burrowing Patterns
  6.  Biology of Species to Be Use in Small Scale Microcosms .  .
References 	

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                               ACKNOWLEDGMENT







     The cooperation and help of the staff at the Gulf Breeze Environmental



Research Laboratory is gratefully acknowledged.   Facilities  in which



experiments were completed were made available to the University of West



Florida through the kind assistance of the Laboratory Director, Dr. Thomas



W. Duke, and the Project Officer, Dr. Frank G. Wilkes.

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                                   FIGURES

Number                                                                  Page

1.  Photo-Bioassay System (A - 24-hour timer;  B -  35  mm camera  with
    automatic advance; D, E - aquaria with 35  cm of sand and  75 1  of
    seawater).

2.  Comparison of the rates of sediment turned under by group of similar
    size.  A different group of lugworms was used for the six replicate
    tests.

3.  Comparison of the rates of sediment turned under by lugworms.
    C-control: E-experimental group exposed to Kepone.   Each  group
    consisted of six lugworms.

4.  Comparison of the rates of sediment turned under by the lugworm,
    Arenicola cristata, C-controls; E-experiment group exposed  to sodium
    pentachlorophenate.  Each group consisted of six lugworms.

5.  One tank in the exposure system for chrysene.

6.  Accumulation of chrysene by lugworms.  Each data point is based on
    average accumulation of five worms.

7.  Exposure system. A-suspended sediment dosing apparatus; B-timer;
    C-crimping bar and solenoids; D-delivery tubes; E-submersible
    pumps to recirculate suspended sediment to the delivery box (not
    labeled); F-seawater headbox; G-splitter box stand pipes; H-mysids,
    oysters and lugworms in exposure tank; 1-exposure tanks on  a water
    table.

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 Number                                                                  Page

 8.   Percent mortality of mysids  exposed  to  control  and  Kepone-
     sorbed sediments for 10 days.

 9.   Effect of Kepone-sorbed sediments  on oyster shell deposition
     (percent growth is relative  to controls).

10.   Number of individuals and species  collected from exposed and
     and control aquaria after 28 days.

11.   Effect of James River sediment on  oyster shell  deposition.

12.   Kepone residues in oysters and lugworms following 28 days of
     exposure to James River sediments.

13.   Percent mortality of mysids  exposed to  control  and  three con-
     centrations of drilling muds for 10 days.

14.   Weekly average oyster growth (N=15).

15.   Oyster shell deposition relative to controls.

16.   Percent mortality of lugworms in control and exposed aquaria.

17.   Number of individuals and species  collected from exposed and
     control aquaria after 100 days.

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     Number                                                            Page
18.   Ba, Cr, and Pb concentrations in oysters exposed to control and
     three concentrations drilling muds for 100 days.

19.   The ratio of Palaemonetes pugio to Cyprinodon variegatus surviving
     after each of five days of predation by Fundulus grandis in con-
     trol and 0.457 mg/1 methyl parathion exposed aquaria.  The lower
     ratio in the exposed aquaria indicated greater predation on P_. pugio.

20.   Preference coefficients for £_. grandis predation on P. pugio and
     juvenile C_. variegatus during five test days in control and 0.475
     mg/1 methyl parathion-exposed aquaria.  Higher coefficients
     indicate greater predation on P_. pugio.  See Farr  (1978) for
     method of calculation.

21.   The ratio of P_. pugio to  C_. variegatus surviving after each of five
     days of predation  by £. grandis in control and acetone control
     aquaria.

22.   The ratio of P_. pugio to  C^. variegatus surviving after each of
     five days of predation of F_. grandis in control aquaria and
     in three concentrations of methyl parathion.

23.   Test apparatus used to observe pinfish  reactions to  flounder
     models: A-fluorescent lights; B-automatic  advance  camera;
     C-realease chamber; D-circular test  tank.

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     Number                                                            Pag





24.  Diagrams of pinfish positions for combined trials  1-10 for each



     time interval of control, light flounder model,  and dark flounder



     model.  Each point represents the mean position  of 10 pinfish for



     each trial, and the X represents the mean of all  10 points.   The



     F values shown below the diagram were calculated by Hotelling's one-



     sample test.  P values correspond to the probability at the tiven



     F value.







25.  Diagram of AGARS trough.  Trough is 125 x 17 x 15 cm high and



     constructed of 6 mm clear plexiglas.  "M" denotes mixing boxes where



     1.5 1 min clean water and test compounds or carriers are combined.



     The flow is divided evenly between pairs of small  chambers on each



     side of the trough.  Water exits from the chambers through a row



     of 7 mm holes.  Water flow maintains a gradient of a control zone



     and three increasing toxicant concentrations (areas 1-4).  Organism



     position can be monitored in both the upper and lower half of each



     area by pairs of infrared light emitting diodes and photo-transistors







26.  Results of a 9-day AGARS test with a group of 4 pinfish.  Mean of



     24 hourly totals of time spent in each of 4 areas of trough versus



     elapsed time of test.  Chlorine produced oxidants were present on



     days 4 and 7 only.








27-  Diagram of one of two replicate troughs used to study pink shrimp



     behavior.   The trough was modified from that shown in Figure 26  in



     that it is partitioned with barriers of plexiglas and plastic screen



     and contains sand.  The presence of each shrimp above the sand

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     Number                                                            Page

     is monitored by two pairs of photo-transistors  and infrared light
     emitting diodes.

28.   An example of an activity graph indicating time in light beams
     (0.33 sec/h) during each hour of the 6-day test.   On days 3 and 4
     shrimp were exposed to 2.0 ppb methyl parathion and carrier.   Light
     and dark bars indicate photo-period.

29.   Mean increase in length by cultured Arenicola cristata during spring
     and early summer; 95% confidence belts are indicated.

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                                   ABSTRACT

     The results of five broadly defined projects  are  reported.
     Cycling of xenobiotics was studied with  a  photo-bioassay  system, which  used
time-lapse photography to evaluate effects  of Kepone and  sodium  pentachlorophenate
on feeding activity of the lugworm, Arenicola cristata.   Radio-labeled methyl
parathion was used to demonstrate fate and  effect  in microcosms  inhabited  by
lugworms.  Uptake and depuration of chrysene  by lugworms  was evaluated in  a
flow-through system.
     A toxic sediment bioassay system was developed to provide a means to  test
effect of dredge spoil.  The system included  microcosms  that held mysid  shrimp,
Mysidopsis bahia; oysters, Crassostrea virginica;  and  lugworms,  Arenicola  cristata.
Effect was tested by using survival of mysids,  shell  deposition  and bioaccumu-
lation by oysters, substrate reworking and  bioaccumulation by  lugworms,  and
settlement of zooplankton as criteria.  Kepone-sorbed  sediment and dredge  spoil
from James River and Houston Ship Channel were tested  for 28 days.  Long term
tests (100 days), with the same systems, were used to  evaluate effect  of a
specific drilling mud from an active exploratory platform.
     Predator-prey tests of sublethal effects of xenobiotics demonstrated  effect
in one prey and two prey systems.  The effects  of methyl  parathion on  predator-
prey relationships between grass shrimp, Palaemonestes pugio;  juvenile sheeps-
head minnows, Cyprinodon varieqatus; and gulf killifish,  Fundulus grandis  were
demonstrated.  The relationship between Palaemonetes pugio and pinfish,  Lagodon
rhomoboides was also demonstrated.  A method  that could be used to evaluate
effect of xenobiotics on predator-prey relationships between  cryptically shaded
flounder and pinfish prey was developed.
     Evaluation of sublethal effects, such  as avoidance of pollution gradients
was studied in a trough-type avoidance response system.  The system was developed

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to be independent of an observer.   It was  tested with  pinfish to demonstrate



that they will avoid chlorine-produced oxidants.  The  system was modified to



demonstrate toxicant induced changes in cyclic burrowing activity by pink



shrimp, Penaeus duorarum, exposed to methyl  parathion.



     Usefulness of small scale microcosms  was  evaluated by developing methods



to culture polychates and crustaceans.  Various aspects of the biology of selected



species were studied.

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                                 INTRODUCTION
     Five broadly defined projects were included in the project goals  of
Grant R804458, "Cycling of Xenobiotics through Marine and Estuarine Sediments."
Two addressed primary goals that were:
     (1) to evaluate cycling of selected xenobiotics or uptake and effect of
         selected energy related compounds in experimental  systems that
         included the lugworm, Arenicola cristata; and
     (2) to develop a toxic sediment assay system involving the lugworm and
         other species.
     The remaining projects were directed toward developing methods to provide
more realistic evaluators, other than acute and chronic toxicity tests, for a
xenobiotic's fate and effect in estuarine and marine ecosystems.  Specifically
these were:
     (1) development of tests involving estuarine and marine crustaceans
         and fishes designed to evaluate how exposure to xenobiotics can alter
         predator-prey relationships
     (2) development and testing of behavioral assays that would provide
         reliable means to evaluate sublethal effects such as avoidance; and
     (3) establishment of small scale microcosms that could be used to test
         fate and effect.
     Although the five broadly defined projects are divergent, commonalities
included either use of systems dominated by  lugworms or evaluation of sublethal
effects in small scale microcosms.
           CYCLING OF XENOBIOTICS BY THE LUGWORM, ARENICOLA CRISTATA
     The impetus to design an assay system involving a lugworm resulted from
development of culture methods for that species and recognition that toxicity
tests employed by EPA for estuarine and marine species do not include an infaunal
organism.

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BETHIC PHOTO-BIOASSAY SYSTEM
     The first test to include an infaunal  representative was  Rubinstein's
(1979) benthic bioassay which uses time-lapse photography to measure effect of
toxicants on feeding behavior of lugworms (Fig.  1).   That organism is ideal for
this type of test because it is widely distributed in littoral  habitats  and has
major ecological impace due to its ability to recycle sediment and transport
xenobiotics into the substrate.  The photo-bioassay system was constructed
based on the lugworm's habit of creating feeding funnels on the surface  of  sed-
iment it occupies.  Under normal circumstances,  active worms,  unperturbed by
xenobiotics in the water column or sorbed on the sediment, create enlarge,  and
recreate obvious funnels.  This pattern on the surface of the  substrate, which
indicates activity of the worm, was monitored by Rubinstein with time-lapse
photographs taken at 12-hour intervals for 72 hours.  Areas of feeding funnels in
exposed  and control aquaria calculated and compared initial trials demonstrated
that there was no significant difference in reworking activity between replicates
under control conditions (Fig. 2).  As worms were influenced by xenobiotics,
their activity, when compared to controls kept under the same environmental
conditions, decreased.  For these experiments the xenobiotic tested was  Kepone
at measured concentrations of 2.8, 4.5, 6.6, 7.4, and 29.5 ug/1.
     Results indicated that A_. cristata was sensitive to Kepone at all concentrations
tested  (Fig. 3).  The highest concentration was acutely toxic.  Lugworms appeared
to be more sensitive to Kepone than many other species normally used in toxicity
tests.   It appeared that in Kepone effected habitats the ability of  lugowrms to
reqork  sediment would be markedly decreased.
CYCLING  OF METHYL PARATHION BY LUGWORMS
     A  second evaluation of cycling of xenobiotics  by lugworms  (Garnas, et  al. 1977)
was directed toward determing compartmentation and  degradation  dynamics of methyl
parathion in a small scale microcosm occupied only  by the wor,  and microorganisms
associated with the organic material on which it feeds.  Ninety percent of radio-

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labelled methyl parathion disappeared from the water column  in  aquaria after
14 days.  Movement into the sediment proved to be the major  compartmentation
phenonomon, with over half of the total radioactivity residing  in the
sediment after two weeks.  The lugworm inhanced movement of  radioactivity into the
sediment and caused dispersion throughout the sediment.   While  volatilization
losses were negligible, steadily decreasing mass balance of  radioactivity in the
system suggested accumulation of unextractable residues  in the  sediment.
Analysis of extractable radioactivity in the sediment and water compartments
by thin layer  chromotography and autoradiography demonstrated rapid degradation
of methyl parathion into a number of more polar products, including P-nitrophenol
and amino-methyl parathion.  While A_. cristata was shown to metabolize methyl
parathion readily  to P-nitrophenol, microbial activity accounted for the majority
of biological  degradation  in the system.
EFFECT OF SODIUM PENTACHLOROPHENATE ON LUGWORM ACTIVITY
     The third analysis of effect of xenobiotics on activities  of the lugworm
was Rubinstein's  (1978) evaluation of effect of sodium pentachlorophenate on
feeding activity.  Na-PCP was used because it is an energy related compound
(oil well drilling fluids) and because it enters estuarine and marine systems
occupied by  lugworms from  numerous non-point sources.  Photo-bioassay methods
developed by Rubinstein  (Fig.  1) were  used in this study.  Stock solutions of
Na-PCP were  prepared from  a  commercial bactericide and introduced into experimental
aquaria at 45,  80, 156, and  276 ug/1.  Comparisons were made between the areas of
feeding funnels in exposed and control aquaria.  Na-PCP had no marked effect on
Feeding activity at the lowest concentration tested;  however,  at the other
concentrations there was significant decrease in activity (Fig. 4).  Some mortality
occurred at the higher concentration.
UPTAKE AND DEPURATION OF CHRYSENE BY LUGWORMS
  The final  analysis of cycling of xenobiotics by lugworms evaluated uptake  1980a
and depuration of  chrysene, another energy related compound (Rubinstein et al. 1980a>

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Worms were exposed to chrysene at measured concentrations  of 0.07,  0.69,  and
2.76 ug/1 in large wooden tanks in an open system that simulated ambient
conditions and the natural habitat (Fig.  5).   After 14 days, exposed worms  were
moved to uncontaminated systems and allowed to depurate for 14 days (considerable
mortality was encountered due to handling in cold weather.)  From lowest  to highest
exposure, lugworms accumulated 65, 516, and 682 ug/1  in 14 days (Fig.  6).   There
was a continued increase in accumulation during that  period so it is probable
that had exposure time been increased, higher levels  of chrysene would have been
encountered before equilibrium was reached.  Little depuration was  observed.
This suggested that lugworms do not have the ability  to degrade chrysene;  thus
there is a good possibility that they have the potential  to introduce chrysene
in various food chains utilized by man.
TOXIC SEDIMENT BIOASSAY SYSTEM
  Many xenobiotics in marine environments have a high affinity for particulate
material  (especially organics) and thus become sequestered in bottom sediments.
Due to increased dredging and maintenance of navigable water there is a greater
need to  evaluate impact of toxic sediments on the biota.   For that reason,  grant
related  activities were directed toward developing a  flow-through toxicity test
that could be used to determine biological effects of contaminated sediments
on representative estuarine organisms and to evaluate resiliency of benthic
communities exposed to contaminated sediments.  The test developed  (Rubinstein
et al. 1980b) incorporated several established toxicity tests that were modified
to examine acute and sublethal effects of dredged sediments on the biota.    It
was designed to serve as a screening tool to detect potential hazards of dredge
spoils prior to disposal in the marine environment.
METHODS  DEVELOPMENT WITH KEPONE-SORBED SEDIMENT
  The approach was to simulate and then compare certain aspects of  the marine
environment before and after deposition of spoil material.  Small scale estuarine
microcosms were assembled in ID-gallon aqauria receiving flowing, unfiltered

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seawater.  Three aquaria received different concentrations  of test sediments,
while three others remained unperturbed and served as  controls.   Comparisons
were made after 28 days.  Organisms included in the test are representative
of three environmental compartments affected by dredging activities.   Included
were mysid shrimp, Mysidopsis bahia; oysters, Crassostrea virginica;  and lugworms,
Arenicola cristata.  Test criteria used to identify effect were:  (1)  survival
of mysids; (2) shell deposition and bioaccumulation of known contaminants by
oysters; (3) substrate reworking and bioaccumulation by lugworms; and (4)
resiliency of the benthic community in terms of numbers and variety of
macrofaunal organisms that settled onto test sediments as planktonic  larve
within 28 days.
    The  exposure system employed is shown in Figure 7-  Sediments exposed to
Kepone at 0.1, 1.0, and 10.0 ug/1 were used during evaluation of the  method.
This was followed by tests with actual dredge spoil material from the James
River and Houston Ship Channel.
    Effect of Kepone-sorbed sediment and mysid survival was time and dose
dependent  (Fig. 8).  Oyster shell growth was significantly inhibited (Fig. 9).
Lugworms had an increasing dose-dependent relationship in concentration of Kepone.
Whole-body residues were 0.043, 0.46, and 1.1 ug/1 19 macrofaunal species were
found  (Fig. 10).  In terms of test criteria, only polychaetes were effected
at the highest exposure.
TESTS WITH DREDGE SPOIL
    James River sediment did not affect mysids significantly although there was
some effect on oysters  (Fig. 11).  Lugworm substrate reworking was reduced in
experimental aquaria.  Oysters and lugworms concentrated Kepone  (Fig. 12).
Little difference was seen in survival of recruited larvae perhaps because few
larvae entered the system during the winter when it was operational.
    Houston Ship Channel sediment did not significantly affect mysid survival
or oyster shell deposition; nor did lugworm activity or macrofaunal composition

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vary significantly between control  and experimental  units.
TESTS WITH DRILLING MUDS
    Since the toxic sediment assay system was proven to be  effective, a long
term (100 day) toxicity test was conducted to determine effect of a specific
drilling mud (Rubinstein et al.  1980c).  Drilling muds were obtained weekly
from an active exploratory platform and tested within one week of collection in
the system, previously described (Fig. 7).  Three dilutions were tested:  10, 30,
and 100 ml/1 by volume.  These concentrations represented those expected
at intervals of several meters to several hundred meters from a point source.
Mud was added to test aquaria to simulate periodic discharge.  The same species
previously employed were included in this test, but mysids  were exposed only
10 days.
    Mysids exposed in the system were  not acutely affected  (Fig. 12).  Oyster
shell growth was significantly inhibited at concentrations  of 30 and 100 ml/1
(Fig. 14 & 15), but there was no mortality.  Lugworms were  severly effected
by exposure to the mud  (Fig.  16).  Mortalities observed were 75% at 100 ml/1,
64% at 30 ml/I, and 33% at 10 ml/I.  Twenty recruited species were present
after 100 days (Fig. 17).  There was no significant difference between popu-
lations in the aquaria.  Ba,  Cr, and Pb were found to have accumulated
significantly in oyster tissue  (Fig. 18).
    The results indicate that physical as well as chemical  properties must be
considered before environmental impact of drilling fluids can adequately be
assessed.  It was also  recognized that composition of drilling muds in highly
variable; thus impact should  be considered on a case by case basis.
PREDATOR-PREY TESTS
    Sublethal concentrations  of xenobiotics, expecially pesticides, may be
expected to affect various aspects of  behavior.  This was demonstrated by Farr
(1977) (partly funded by this grant) who  demonstrated that methyl  parathion
impairs the ability of  grass  shrimp, Palamonetes pugio, to escape  predation by

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the gulf killifish, Fundulus grandis.  Although £_.  grandis  ate no more exposed
than unexposed shrimp, the predators took less time to capture exposed prey.   If
pesticides have different effects on species in a multiprey systems,  predators
may be expected to consume a higher than normal proportion  of affected species.
The result would be more rapid accumulation of a xenobiotic.
TWO PREY SYSTEM
    Palaemonetes pugio and juvenile sheepshead minnow, Cyprinodon variegatus
were exposed to methyl parathion for 24 hours before introduction of  Fundulus
grandis, the predator (Farr 1978).  Two experiments were run for five days:
a preliminary experiment at 0.475 ug/1, and a definitive experiment which included
a carrier control and methyl parathion concentrations of 0.024, 0.119, and 0.475
ug/1.
    In the first experiment when the prey were exposed to the pesticide, gulf
killifish  consumed a greater proprotion of grass shrimp relative to  sheepshead
minnows  (Fig. 19).  Predation was also relatively greater on P_. pugio than on
C_. variegatus as compared with controls (Fig.  20).   The second experiment tested
effect of a  range of methyl parathion  concentrations and of acetone (carrier)
on prey  consumption.  In both control  and acetone-control aquaria, the ratio of
shrimp to fish increased rapidly during the test and did not differ,  indicating
strong predator preferences for sheepshead minnows and no acetone-related
effect (Fig. 21).  As the concentration of pesticide was increased in test
aquaria, the ratio of grass shrimp to  sheepshead minnows decreased with time
(Fig. 22).   Increasing the concentration resulted in increased consumption of
grass shrimp relative to fish prey, an obvious example of how a pesticide can
alter relative proportions of prey in  a predator's diet.
EXPOSED AND  CONTROL PREY IN THE SAME SYSTEM
    Test systems were modified from the work of Farr  (1978) and focused on the
effect of xenobiotics on exposed and control prey in the same systems  (cripe  1979)
Equal numbers of pinfish, Lagodon rhomboides,  and toxicant exposed and  control

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grass shrimp. Palaemonetes pugio, were placed in two replicate tanks  containing
removable dividers.   Approximately 20 minutes after the dividers  were removed,
surviving shrimp were counted to determine differential predation between exposed
and control prey.  Prey were pleopod clipped for identification.   Clipping was
emonstrated to have no significant effect on predation.
    Significantly fewer shrimp survived predation after exposure  for  24 hours
to 1.2 ppb methyl parathion.  Exposure to 1.3 ppb Trithion for 24 and 72
hours produced to significant difference in predation.
CRYPTIC SHADING AND PREDATION
    The behavior between a bothid flounder, Paralichthys albigutta, and its
prey the pinfish, Lagodon rhomboides, can be exploited to evaluate how a
xenobiotic could alter predatory strategy of flounder or avoidance response
of pinfish.  Before the relationship could be tested it was necessary to
determine what the prey's normal response is to flounder exhibiting various
degrees of cryptic coloration.
    For these experiemtns, models of flounder prey were used (Ashton  1980).
These were black and white photographs laminated between plastic and  attached
to a plastic outline of a flounder.  A circular tank was used as  the  arena
(Fig. 23).  Ten prey were released from a central holding chamber and photographs
were taken at 0.5, 1.0, and  1.5 minutes to record response to the flounder
model.  Ten trials were completed for control, dark model, and light  model
treatments.  Position of the school of prey relative to the predator  model was
calculated.  The group response for ten trials at each time interval  was com-
bined for each treatment group and random versus non-random distribution was
tested.
    Control data indicated that pinfish were randomly  distributed in the absence
of a model (Fig. 24).  In the case of the light model  that represented a cyptically
shaded flounder there was no significant avoidance  (Fig. 24).  Pinfish swam
directly over the model.  In the case of the dark model, the pinfish preferred

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the opposite side of the tank from the model  (Fig.  24).   Pinfish did not swim
around the tank as they did in control and light model  experiments.
    This system is now ready to be tested to determine  how sublethal exposure
to xenobiotics can modify the antipredator response of  the pinfish.
           EVALUATION OF SUBLETHAL EFFECTS IN SPECIAL TEST SYSTEMS
AVOIDANCE OF POLLUTION GRADIENTS
    It has often been observed that fish and invertebrates avoid pollution
gradients.  Most apparatus designed to detect avoidance of pollutants by
aquatic organisms require visual observations of the test organisms  in steep
pollution gradients.  The aquatic Gradient Avoidance Response System (AGARS)
was developed to eliminate these limitations (Cripe, 1979a).   This system
(Fig. 25) allows animals to choose between one uncontaminated zone and three
increasingly toxic zones in a gradient trough that is monitored for extended
periods by infrared  light sources, sensor, and a microprocessor.  Data are
accumulated hourly and processed by a paper tape reader/calculator/plotter  system
that records the time test animals remain in each zone  and compares  behavior
before and during test exposures.  Initial tests in AGARS indicated that pinfish,
Lagodon rhomboides will avoid chlorine-produced oxidants at concentrations  of
0.02-0.04mg/l (Fig.  26).  The system  is a prototype that can be enlarged by
using more powerful  lights and greater microprocessor memory capacity.  In
addition to several  species of fish,  baseline data have also been obtained
with blue crabs, Callinectes sapidus, and penaeid shrimp.  The system could
also be used to test thermal or salinity preferences.
TOXICANT INDUCED CHANGES IN CYCLIC BURROWING PATTERNS
          The pink shrimp, Penaeus duorarum, is a species that is very sensitive
to xenobiotics.  Since no life-cycle  toxicity test exists for penaeid shrimp,
the only criterior of effect that has been used for hazard assessment is
death.  Pink shrimp  normally remain buried in substrate during the day and
emerge at night.  Stress from both lethal and sublethal pesticide exposures

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disrupt this pattern and may result in the shrimp's continuous presence above
the substrate.  Such activity would increase predation and cycling of xenobiotics.
To evaluate the effect of toxicant-induced disruptions in the cyclic burrowing
pattern, an apparatus was constructed (Gripe 1979b) from a modified AGARS system.
Two troughs were employed with sensors only in the upper level.  Each trough
was partially filled with sand and compartmentalized into four areas by plastic
screen  (Fig. 27).  Shrimp were placed in each compartment on a 12L-12D cycle and
monitored for six days.  One trough was exposed to 2 ppb methyl parathion on
days 3  and 4 of the test.
    The results indicated variability in absolute activity level of a particular
shrimp  on different days as well as between shrimp.  An activity index was
calculated by dividing the mean of the hourly light beam interruptions for each
dark period into the mean hourly counts for the succeeding light period.  The
index was lower for controls that exposed shrimp.  On a daily basis there was
significant difference in activity between days when toxicant was added and days
when it was not (Fig. 28).
    In  conjunction with  the development of trough systems a device to detect
potentially dangerous electrical currents in saltwater holding tanks was developed
(Gripe  & Stokes 1978).
                            SMALL SCALE MICROCOSMS
    The usefulness of microcosms in evaluating fate and effect of various
xenobiotics is well documented.  Several of tests developed under grant auspices
were actually completed  in  laboratory microcosms.  Bourquin et al.  (1979)
redescribed these as well as three other types.  A part of the grant effort was
directed toward evaluating  various aspects of the biology of  selected species
that could be used in microcosms.
POLYCHAETES
    Pond culture of lugworms (D'Asaro, in manuscript) was directly  linked  to
development of techniques to use lugworms in small scale  systems.   The  results

-------
demonstrated rapid growth rates of lugworms over a 90-day period at densities
of 60 or more worms per square meter when ground seagrass (Thalassia) was used
as a food  (Fig. 29).  These data were used by Rubinstein (1979) to develop various
toxicity tests in which lugworms were used as a primary component in the system.
    White  (1978) used microcosms to evaluate the impact of three predators
(Neanthes  succinea, Glycera americana, and Callinectes sapidus.  The blue crab,
C_. sapidus was the most effective predator especially on juvenile lugworms that
do not burrow deeply.
    Lasfargues (1980) examined the role of bacteria as a food source for lugworms
in microcosms.  Lugworms were allowed to consume composted seagrass; then
comparisons were made between biomass of bacteria and yeast in the grass and
feces.  There was a significant reduction in the population of bacteria but not
.in the population of yeast  in the feces.  There was also evidence of selective
digestion  of bacteria.  A gram negative bacterium, isolated from composted
seagrass,  was cultured and  used to enrich compost fed to worms.  The enrichment
caused a significant increase in growth.
    Redig  (1980) examined culture methods that could be used to rear Polydora
ligni, a species that can be easily  included in microcosms.
ISOPODS
    Ligia  exotica is a semi terrestrial isopod restricted to the immediate
supralittoral zone, an area often heavily  impacted by oil spills.  Orientation
and social behavior in L_. exotica was evaluated by Farr  (1978).  The tendency
of L_. exotica to aggregate  and orient to enviornmental stimuli was examined  in
circular outdoor tanks or small aquaria.
    In the circular tanks,  experimental animals released in the center  of the
arena were allowed to aggregate for  24 hours under clay saucers placed  around
the periphery of the arena.  The resulting aggregations were not  random indicating
that \^. exotica actively seeks conspecifics.  In  tests  in aquaria, L_. exotica
significantly selected shelters containing conspecifics or a shelter conditioned

-------
by previous occupancy by a conspecific.   Other experiments demonstrated that
distribution of L^. exotica appears to be influenced initially by raised landmarks
on the shoreline.  Observations on social behavior were also reported.
    Levy (1980) described the breeding habits and brood pouch development of
Erichsonella altenuata, an isopod ideal  for microcosm studies because it is
easy to culture in closed systems, and it is a representative of marine grassflat
communities.
MYSIDS
    Plaia  (1980) described the complete embryogenesis and organogenesis of
Mysidopsis bahia, a species presently used as a standard organism in toxicity
tests.
ANOSTRACANS
    Logue  (1980) examined the effects of temperature and diet on growth of a
freshwater anostracan, Streptocephalus seali. This species wer found to be easy
to culture.  It matures rapidly in two weeks thus it may be useful for life-
cycle tests.

-------
Fig.  1.  Photo-Bioassay System (A - 24-hour timer;  B  -  35  mm  camera with automatic advance; D, E - aquaria
         with 25 cm of sand and 75 1  of seawater).

-------
    40'
    IOC
uJ
   -oo-
   3OC-
            Trial
            Trial  4
                                              Trial 2
                                   Trial 3
Trial  5
Trial  6
           12   24    36   48   60   72  0    12    24
                                            36   48    60   72
                                                TIME  (hours)
            Fig. 2.  Comparison of the  rates  of sediment  turned under by group  of similar size.   A different group
                     of  lugworms was used  for the six replicate tests.

-------
cvJ
Q
LU
GQ
~r"_

ID
Q
      800f
600h
              Non- Detectable
                                        144
800



600



400



200



   0
                                                            2.8 jjg /I   Kepone
                                                                          •
                                                                          P-- —-"" c
                           96    120   144
LJ
QL
LJ
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£
(T
ID
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soor
               6.6 jjg/l  Kepone
                                                    800
                                                          600
                                                    400
                                                          200
                           72     96    120   144
                                                            0
                                                            29.5 ;jg/l  Kepone
                                                       0     24    48    72    96    120   144
        Fig.  3.
                                         TIME  (hours)
          Comparison of the rates of sediment turned under by lugworms,
          exposed to Kepone.   Each group  consisted of six lugworms.
                                                                        C-control; E-experimental group

-------
                                      IIMF. (hour',)
Fig. 4.  Comparison of the rates of sediment turned under by  the  lugworm,
         Arenicola cristata, C-controls; E-experiment group exposed  to  sodium
         pentachlorophenate.  Each group consisted of six lugworms.

-------
                          CHRYSENE
HEAD30X
                                                    SYRINGE  PUMP
                                  EPOXY COATED
                                    WOOD  TANK
EFFLUENT
  POND
Fig. 5.  One tank in the exposure system for chrysene.

-------
         1000^
         800
         600
LU

LJ


cr:

o
         400
         200
0
                                                            5
 6        8

TIME (doys)
                                                            10
                                                                 12
                                                                                 2.76
                                                                            0.035 pa/I

                                                                           .CONTROL
14
Fig.  6.  Accumulation of chrysene by lugworms.  Each data point  is based on average accumulation of
        five worms.

-------
EXPOSURE SYSTEM
           	. F
exposure tanks on a water table.
                   oysters and lugworms  in

-------
                                                                            OO
                                                                            >>
                                                                            CO
    50
    40
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                                              SEDI MENT KEPONE

                                                CONCENTRATION

                                                              (ppm)


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-------
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                   2.0
                          0
                                     SEDIMENT KEPONE CONCENTRATION (ppm)
                                                                      10.0
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                             14
21
                                                   0
                                                                  28
                                                               Q
                                              d
                                      p o

           — o  o
           0 —  0
                            SEDIMENT KEPONE CONCENTRATION,
                             14          21

                                 DAYS
                                                                  28
Fig. 9.  Effect of  Kepone-sorbed sediments on oyster shell deposition  (percent
         growth is  relative to controls).

-------
                    ANNELIDA    MQLLUSCA   ARTHROPODA    CHORDATA
ouu
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§ 200
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NUMBERS OVER BARS REPRESENT
THE NUMBER OF SPECIES


1
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                    I    1.0       §    1.0       §    1.0        I    1.0
                    cj             o              o              u

                      NOMINAL KEPONE SEDIMENT CONCENTRATION, ppm
Fig. 10.  Number of individuals and species collected from exposed and
          control aquaria after 23 days.

-------
                                                SHELL GROWTH,  PERCENT RELATIVE

                                                       mm              GROWTH


                                                      N   ^        M   -^   C7)  CO   O
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                                             CONTROL
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                                                              CO
Fig.  11.  Effect of James River sediment on oyster shell deposition.

-------
               en
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                             OYSTERS
                                    0.51
                             N.D.
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                                        0.75

                                       Aig/g
                                 N.D.
                                                  CON-    EX-

                                                  TROL POSED
               N.D., NON-DETECTABLE «0.02/K)/g).
Fig.  12.   Kepone  residues in oysters and lugworms following 28 days  of
          exposure to James River sediments.

-------
                    £
                    cr
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                                                           DRILL  MUD
                                                           CONCENTRATION
                                                                   (m I /I)
4        6

   TIME (days)
                                                            8
                                           100

                                            30

                                            10
10
                                                   12
Fig. 13.  Percent mortality of mysids exposed to control and  three concentrations of drilling muds for
         10  days.

-------
                  £
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    DRILL MUD CONCENTRATION

                       (ml/1)

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                              I   s
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  TIME  (weeks)
10      12
Fig. 14.  Weekly average oyster growth  (N=15).

-------
                X
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                                         DRILL MUD CONCENTRATION
                                                               (ml /I)
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                      TIME (weeks)
                                                                   30
                                                                   100
10
12
Fig. 15-  Oyster shell deposition relative to controls.

-------
H

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C  10 30 100
                                    DRILL MUD CONCENTRATION,  m!/l
Fig.  17.  Number of individuals  and species collected from exposed and control aquaria  after 700 days.

-------
                          OYSTER TISSUE  RESIDUES (jjg/g  DRY WT)	
o

o
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     Fig. 18.   Ba,  Cr, and Pb concentrations in oysters  exposed to control and three concentrations drilling

               muds  for 100 days.

-------
               3.0
           o
           Q
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                1.0
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                                    CONTROL
                  0
                                                   OF  PREDATION
Fig.  19.
The ratio of
of predation
lower ratio
 Palaemonetes  pugio  to Cyprinodon van'egatus surviving after each  of five  days
 by Fundul us grandi s  i n . control and 0.475 mg/1 methyl  oarathion  exposed aquaria.
in the exposed aquaria indicated greater predation on  P_.  pugio.
                                                                                                      The

-------
                ).0
           UJ
           o

           t   2.C

           6
           o

           LJ
           UJ
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           UJ
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                                                                        CONTROL
                  0
234

  DAYS  OF PREDATICM
Fig.  20.   Preference  coefficients for F.  grandis  predation on P. pugio and juvenile C   varieaatus durina
          five  test days in control and 0.475 mg/1  methyl parathic^posed aquar a   Hiaher^coefficients
          indicate greater predation on P.  ^u^o.  See  Farr (1978) for method of calculation   COefflclents

-------
6.0
                             DAYS  OF PREDATION
Fig.  21.   The ratio of P_.  pugio
          F.  qrandis in~"control
                to C_.  variegatus surviving after each of five days  of  predation by
                aquaria  and  in  three concentrations of methyl parathion.

-------
              6.0
          -Z.   5-°
          b
          b

          |   4.0
              3.0
O
^
co
£
u
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0
          <   2.0
               1.0
                0
        0
                                                                     CONTROL
                                                                     0.024 ijg/l
                                       234

                                          DA.YS CF  PREDATION
Fig.  22.   The  ratio  of £_. pugio to C_.  variegatus surviving after each  of  five days of predation by
          £. grandis  in concentrations of methyl parathion.

-------
                                                           1
Fig. 23.  Test apparatus used to observe pinfish reactions to flounder models: A-fluorescent lights;
          B-autoniatic advance camera; C-release chamber; D-circular test tank.

-------
elapsed
  time
   in
minutos
control
 light
model
 dark
model
  0.5
                    = O.I445
                   P=0.8677
                        F=3 9156
                        P =0.0652
                        F=I5.0950
                        P = 0.0020
    .0
                   F=0.2753
                   P=0.7663
                         P =0.0652
                        = 35.7808
                        P=O.OOOI
   1.5
                   F = 0.207I
                   P = 0.8I72
                         F=IJ077
                         P = 0.2282
                       F=3b.yb69
                        P=O.OOOI
 Fig.  24.  Diagrams of pinfish positions  for combined  trials 1-10 for each time
          interval of control, light flounder model,  and dark flounder model.   Each
          point represents the mean position of 10 pinfish for each trial, and the
          X represents the mean of all  10 points.   The  F values shown below the
          diagram were calculated by Hotelling's one-sample test.  P values correspond
          to the probability at the given F value.

-------
                                                               HIGH
                                              MEDIUM
                                    LOW
                 CONTROL
                                                                                            OVERFLOV/
                                                         PHOTOTRANSISTOR
Fig.  25.   Diagram of AGARS trough.  Trough is 125 x  17 x 15 cm high and constructed of 6 mm clear plexiglas.
          "M"  denotes mixing boxes where 1.5 1  min clean water and test compounds or carriers  are combined.
          The  flow is divided evenly between pairs of small chambers on each side of the trough.  Water exits
          from the chambers through a row of 7 mm holes,  inlater flow n.aintains a gradient of a control zone
          and  three increasing  toxicant'concentrations  (areas 1-4).   Organi
          the  upper and lower half  of eacn area by pairs of infrared light
sm position  can be monitored  in  both
emitting  diodes and onoto-transistors

-------
                   o
                   ro
                   UJ
                   cr
                   UJ
                        8000
                        6000
                        4000
                   <   2000
                            0




	













;x:x;:.v


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.:'••':'£:'

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PRESENT
(mg/l)
.21
SH


1
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00






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0
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[
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1 234 56
DAY



Area 4
Area 3
Area 2
Area I




iv :.:. ;









-

I
j
i
i
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Fig.  26.
Results  of  a 9-day AGARS test with a group of 4 pinfish.  Mean of 24  hourly totals of  time spent
in each  of  4 areas of trough versus elapsed time of test.  Chlorine produced oxidants  were prese
          on  days 4 and 7 only.
                                                                                                present

-------
                                                                                      Overflow
                                                                                        drain
          Sand
                            Phototransistor
Fig.  27.   Diagram of one of two replicate troughs used to study  pink shrimp behavior.   The  trough was
          modified from that shown in  Figure 26 in that it is  partitioned with barriers of  plexiglas and
          plastic screen and contains  sand.  The presence of each  shrimp above the sand is  monitored by
          tow pairs of photo-transistors and infrared light emitting diodes.

-------
          6000
 o


 "
n)
rO
      UJ

      CD
          5000
         4000
          3000
          2000
          1000
              0
                   III
                                     EXPOSURE
                  24
48
 72


HOUR
96
120     144
Fig. 28.
   An example of an activity graph indicating  time in  light beams (0.33 sec/h) during each

   hour of the 6-day test.  On days 3 and 4 shrimp were exposed to 2.0 ppb methyl parathion

   and carrier.  Light and dark bars indicate  photo-period.

-------
              IO.O h
                       20
60
                                     Days
140
Fig.  29.   Mean  increase in  length  by  cultured Arenicola cristata during spring and
          early summer; 95% confidence  belts are indicated.

-------
                                   REFERENCES


Ashton, Charles.  1980.  The response of pinfish,  Lagodon  rhomboides,  to  cryptic
     and non-cryptic flounder, Paralichthyes  albigutta,  an  examination of the
     value of cryptic shading to a predator.   Masters  thesis,  University  of
     West Florida, June 1980.

Bourquin, A.W., R.L. Barnas, P.M. Pritchard,  F.G.  Wilkes,  C.R.  Cripe,  and
     N.I. Rubinstein.  1977.  Interdependent  microcosms  for the assessment of
     pollutants in the marine environment.   Intern.  J.  Environ.  Studies., 13:131-140.

Cripe, C.R. 1979a.  An automated devise (AGARS)  for  studying avoidance of
     pollutant gradients by aquatic organisms.  J.  Fish.  Res.  Bd.  Can., 35(1):11-16.

Cripe, C.R. 1979b.  An automated apparatus  to record toxicant-induced  changes
     in cyclic burrowing patterns of pink shrimp (Penaeus  duorarum).   Research
     Review, September 1979, pp 26-27.

Cripe, C.R. and B.E. Stokes. 1978.  A device  to  detect potentially dangerous
     electrical currents in saltwater holding tanks.  Prog.  Fish.  Cult.,  40(2):74-75.

D'Asaro, C.N. 1980.  Pond culture of the lugworm,  Arenicola cristata as a source
     of bait (manuscript).

Farr, J.A. 1977.  Impairment of antipredator behavior in Palaemonetes  pugio
     by exposure to sublethal doses of parathion.  Trans.  Am. Fish. Soc. ,  106(3):287-
     290.

Farr, J.A. 1978.  The effect of methyl parathion on  predator preference for  two
     estuarine prey species.  Trans. Amer.  Fish. Soc., 107(1):87-91.

Farr, J.A. 1978.  Orientation and social behavior in the supralittoral isopod
     Ligia exotica Bull. Mar. Sci., 28(4):659-666.

Garnas, R.L., C.N. D'Asaro, N.I. Rubinstein,  and R.A.  Dime. 1977.   The fate  of
     methyl parathion in a marine benthic microcosm.  Paper #44 in Pesticide
     Chemistry Division, 173 rd ACS meeting,  New Orleans,  Louisana, March 20-25,  1977

Lasfargues, J.E. 1980.  Evaluation of bacteria as  a  food resource  for  Arenicola
     cristata.  Masters thesis, University of West Florida, September  1980.

Levy, I.C. 1980.  Breeding habits and ontogeny of Erichsonella attenuata  reared
     in the laboratory.  Masters thesis, University  of West Florida, September 1980.

Logue, C.L. 1980. Effect of temperature and diet on  growth, longevity, and egg
     production of Streptocephalus seali.  Masters thesis, University  of  West
     Florida, September 1980.

Plaia, W.C. 1980.  Embryogenesis and organogenesis of Mysidopsis bahia.  Masters
     thesis, University of West Florida, September 1980.

-------
Redig, M.X. 1980.  Optimal temperature-haline conditions  for development
     of Polydora ligni.   Masters thesis, Florida State University.

Rubinstein, N.I. 1978.  Effect of sodium pentachlorophenate on  the  feeding  activity
     of the lugworm, Arenicola cristata. In:  K.R. Rao, ed., Chemistry,  Pharmacology
     and Environmental Toxicology of Pentachlorophenol, Plenum  Press,  New York,
     pp.175-179.

Rubinstein, N.I. 1979.  A benthic bioassay using time-lapse photography to
     measure effects of toxicants on feeding behavior of lugworms.   In: W.B.
     Vernberg et al. editor, Marine Pollution: Functional Responses.
     Academic Press, New York. pp.341-355.

Rubinstein, N.I., R.A. Dime, and C.E. Ashton. 1980a.  Chrysene  uptake  and
     depuration by  the lugworm  (Arenicola cristata). In:  N. Richards,  editor,
     Proceedings Symposium on Carcinogenic Polynuclear Aromatic Hydrocarbons  in
     the Marine Environment, Academic Press, New York.

Rubinstein, N.I., F.G. Wilkes, C.N. D'Asaro, and C. Sommers. 1980b.  Effects  of
     contaminated sediments on representative estuarine organisms and  developing
     benthic communities.  In: Robert Baker, editor, Contaminants and  Sediments,
     Vol.  I., Ann Arbor Sciences pp. 445-461.

Rubinstein, N.I., R.A. Rigby, and C.N.  D'Asaro.  1980c.  Effects of whole used
     drilling muds  on representative estuarine organisms.   In:  Proceedings  from
     a  Symposium or Research on  Environmental Fate and Effects  of Drilling  Fluids
     and Cutting.

White,  C.B. 1978.   Predation on  cultured  lugworms  (Arenicola cristata).  Masters
     thesis, University of West  Florida.

-------