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September 1986
Guidance for the
Reregistration of
Pesticide Products
Containing Azinphos-Methyl
as the Active Ingredient
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SEP M 1986
GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS
CONTAINING
AZINPHOS-METHYL
AS THE ACTIVE INGREDIENT
EPA CASE NUMBER 235
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20'460
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TABLE OF CONTENTS
I. Introduction P.I
II. Chemical(s) Covered by this Standard P.4
A. Description of Chemical
B. Use Profile
III. Agency Assessment p.7
A. Summary
B. Preliminary Risk Assessment
C. Other Science Findings
D. Tolerance Reassessment
IV. Regulatory Position and Rationale P.30
A. Regulatory Positions
B. Criteria for Registration
C. Acceptable Ranges and Limits
D. Required Labeling
V. Products Subject to this Standard P.56
VI. Requirement for Submission of Generic Data .... P.58
A. What are generic data?
B. Who must submit generic data?
C. What generic data must be submitted?
D. How to comply with DCI requirements
E. Procedures for requesting a change in protocol
F. Procedures for requesting extensions of time
G. Existing stocks provisions upon suspension or
cancellation
VII. Requirement for Submission of Product-Specific Data p.63
VIII. Requirement for Submission of Revised Labeling . . p.64
IX. instructions for Submission P.65
A. Manufacturing use products (sole active)
B. Manufacturing use products (multiple active)
C. End use products
D. Intrastate products
E. Addresses
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APPENDICES
I. DATA APPENDICES
Guide to Tables
Table A
Table B
Table C
II. LABELING APPENDICES
Summary of label requirements and table
40 CFR 162.10 Labeling Requirements
Physical/Chemical Hazards Labeling Statements
Storage Instructions
Pesticide Disposal Instructions
Container Disposal Instructions
III. USE INDEX APPENDIX
IV. BIBLIOGRAPHY APPENDICES
.Guide to Bibliography
Bibliography
V. FORMS APPENDICES
EPA Form 8580-1 FIFRA §3(c)(2)(B) Summary Sheet
EPA Form 8580-6 Certification of Attempt to Enter Into an
Agreement with Other Registrants for Development
of Data
EPA Form 8580-4 Product Specific Data Report
EPA Form 8570-27 Formulator's Exemption Statement
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I. INTRODUCTION
The Registration Standards Program
EPA has established the Registration Standards program in order
to provide an orderly mechanism by which pesticide products
containing the same active ingredient can be reviewed and
standards set for compliance with FIFRA. The standards are
applicable to reregistration and future applications for
registration of products containing the same active ingredient.
Each registrant of a product containing the active ingredient
subject to this Standard who wishes to continue to sell or
distribute that product must bring his product and labeling
into compliance with FIFRA, as instructed by this Standard.
Pesticides have been grouped into use clusters and will be
reviewed on the basis of a ranking scheme giving higher
priority to (1) pesticides in clusters used on food and feed
crops; and (2) pesticides produced in large volumes.
The Registration Standards program involves a thorough review
of the scientific data base underlying a pesticide's registration,
The purpose of the Agency's review is to reassess the potential
hazards arising from the currently registered uses of the
pesticide; to determine the need for additional data on health
and environmental effects; and to determine whether the pesticide
meets the "no unreasonable adverse effects" criteria of FIFRA.
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In its review EPA identifies:
1. Studies that are acceptable to support the data
requirements for the currently registered uses of the pesticide.
2. Additional studies necessary to support continued
registration. The additional studies may not have been required
when the product was initially registered or may be needed to
replace studies that are now considered inadequate.
3. Labeling revisions needed to ensure that the product is
not misbranded and that the labeling is adequate to protect man
and the environment.
The detailed scientific review, which is not contained in this
document, but is available upon request^-, focuses on the pesticide
active ingredient. The scientific review primarily discusses the
Agency's evaluation of and conclusions from available data in its
files pertaining to the pesticide active ingredient. However,
during the review of these data, the Agency is also looking for
potential hazards that may be associated with the end use products
that contain the active ingredient. The Agency will apply the
provisions of this Registration Standard to end use-products if
necessary to protect man and the environment.
scientific reviews are available upon request from the
Information Services Section, Room 236, CM# 2, 1921 Jefferson
Davis Highway, Arlington, Va., 22202 (703-557-4453). Ninety
days after the issuance.of the standard, the reviews may be
purchased from the Technical Information Service, 5285 Port
Royal Road, Springifeld, Va., 22161.
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EPA's reassessment results in the development of a regulatory
position, contained in this Registration Standard, on-the
pesticide and each of its registered uses. See Section IV -
Regulatory Position and Rationale. Based on its regulatory
position, the Agency may prescribe a variety of steps to be
taken by registrants to maintain their registrations in compliance
with FIFRA. These steps may include:
1. Submission of data in support of product registration;
2. Modification of product labels;
3. Modifications to the manufacturing process of the pesticide
to reduce the levels of impurities or contaminants;
4. Restriction of the use of the pesticide to certified
applicators or other specially trained individuals;
5. Modification of uses or formulation types; or
6. Specification of packaging limitations.
Failure to comply with these requirements may result in the
issuance of a Notice of Intent to Cancel or a Notice of Intent
to Suspend (in the case of failure to submit data).
In addition, in cases in which hazards to man or the environment
are identified, the Agency may initiate a special review of the
pesticide in accordance with 40 CFR Part 154 to examine in depth
the risks and benefits of use of the pesticide. If the Agency
determines that the risks of the pesticide's use outweigh the
benefits of use, the Agency may propose additional regulatory
actions, such as proposed cancellation of uses of the pesticide
which have been determined to cause unreasonable adverse effects on
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the environment. EPA has authority under the Data Call-in (DCI)
provisions of FIFRA sec. 3(c)(2)(B) to require that registrants
submit data to answer our questions regarding the chemical, toxico-
logical and environmental characteristics and fate of a pesticide..
This Registration Standard lists the data EPA believes are necessary
to resolve our concerns about this pesticide. These data are listed
in Section V - Requirement for Submission of Generic Data, and
Section VI - Requirement for Submission of Product-Specific data.
Failure to comply with the DCI requirements enumerated in this
Registration Standard may result in issuance by EPA of a Notice of
Intent to Suspend the affected product registrations.
Registrants are reminded that FIFRA sec. 6(a)(2) requires them to
submit factual information concerning possible unreasonable adverse
effects of a pesticide at any time that they become aware of such
information. You shall notify the Agency of any information,
including interim or preliminary results of studies, if those
results suggest possible adverse effects on man or the environment.
This requirement continues as long as your products are registered
by the Agency.
II. CHEMICAL COVERED BY THIS STANDARD
A. Description of Chemical
The following chemical is covered by this Registration Standard:
Common name: Azinphos-methyl
Chemical name: 0,0-dimethyl-S-[(4-oxo-l,2,3-benzotriazin-3(4H)-
yDmethyl] phosphordithioate
Chemical class: Organophosphate
CAS Number: 86-50-0
OPP (Shaughnessy) Number: 058001
Empirical Formula:
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Tirade names: metiltrizotion, carfene, cotion, cotion-methyl,
gusathion, gusathion-M, guthion, Bay 9027,
Bay 17147, R-1582 and chrysthyon
Description of physical characteristics of chemical:
Technical Azinphos-methyl
Color: Yellow-Brown
Physical State: Waxy solid
Melting Point: 60-63°C
Solubility: soluble in wide range of organic
solvents, insoluble in water
Boiling Point: decomposes
Specific gravity: 1.44 at 20°C
Vapor Pressure: 2.2 x 10~7mm Hg at 20°C
Molecular Weight: 317.1
Predominant Uses: Cotton, Apples and Peaches
Types of Pesticide: Insecticide, Acaricide and Molluscicide
Mode of Activity: Cholinesterase Inhibition
Pest Controlled: More than 200 Agricultural Pests (Refer to
Appendix III. for Pesticide index)
B. use profile
Azinphos-methyl is a broad spectrum organophosphate insecticide,
acaricide and molluscicide that has been marketed in the U.S. for
over 25 years. Azinphos-methyl was first registered by Mobay
Chemical Corporation in 1959. Technical azinphos-methyl is produced
by Bayer AG (Federal Republic of Germany), Makhteshim Chemical
Works (Israel), and in the United States by Mobay Chemical
Corporation and Aceto Chemical Company. Approximately 3 million
pounds active ingredient are used annually for control of more than
200 pests on about 50 sites. There are approximately 125 single
active ingredients and 19 multiple active ingredient products
registered including the following formulation types:
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Technical (85%, 94%)
Formulation Intermediate (lib/gal, 21%, 22%, 25%)
Dust , (2%, 2.5%, 3%, 6%)
Granular (5%, 7%, 10%)
Wettable Powder (25%, 50%, 62.5%)
Emulsifiable Concentrate (0.25 Ib/gal, 0.75 Ib/gal, 1 Ib/gal,
1.5 Ib/gal, 2 Ib/gal,
5%, 12.37%)
Flowable Concentrate (2 Ib/gal, 3 Ib/gal)
Soluble Concentrate (12.4%)
(Liquid formulations containing greater than 13.5% active
ingredient are classified as restricted use pesticides).
Methods of Application include:
Foliar spray or dust by air or ground equipment
Soil broadcast preplant or at planting
Soil broadcast (in established plantings)
Soil drench (transplant water or immediately after transplanting)
Soil incorporated preplant
Bark spray
Azinphos-methyl is used as a foliar spray on a variety of field,
vegetable, fruit and nut crops. Major use sites include cotton,
apples, peaches and almonds. Other registered uses include
potatoes, tomatoes, pears and cherries, pistachio nuts, peas
(field), sugarcane, onions, celery, spinach, broccoli, Brussels
sprouts, cabbage, cauliflower, beans, soybeans, peppers,
cucumbers, melons, citrus fruit, apricots, nectarines, plums,
prunes, vetch, safflower, blackberries, blueberries, cranberries,
grapes, strawberries, filberts, pecans, walnuts, wheat,
grass, alfalfa, clover, artichokes, eggplant, crabapples,
quinces, boysenberries, loganberries, raspberries, oats, rye,
barley, birdsfoot trefoil, tobacco, ornamentals, and forests.
(Refer to Appendix III. for usage rates and calculations of
amount of active ingredient used). Approximately 70% of azinphos-methyl
use is attributed to use on major orchard and cotton pests. The two
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largest usage sites are cotton and apples comprising about 34%
and 24%, respectively, of annual azinphos-methyl usage. Recommended
application rates for cotton range from 1/8 to 1/4 Ib a.i. per
acre and for apples 1-2 Ibs a.i. per acre.
Azinphos-methyl is an important component of the Integrated Pest
Management (IPM) programs in tree fruit producing states.
Azinphos-methyl is considered to be only slightly toxic to certain
predators of stone and pome fruit pests, and is not plant phytotoxic
or persistent in the soil. Consequently, it is widely used in
IPM programs in tree fruit producing states.
Overall, the usage has been declining in markets where the
synthetic pyrethroids are being heavily used. Cotton and tomatoes
ara examples of this market shift. Azinphos-methyl is used, in
most areas of the U.S. where fruit, vegetable and nut crops are
grown. The least likely area of significant usage is the corn
belt. Azinphos-methyl usage in the future would depend to some
degree on regulatory status of competing insecticides. Two of
these, parathion and phosmet are also under review by the Agency.
III. AGENCY ASSESSMENT
A. SUMMARY
The Agency has reviewed data submitted to support the
registration of azinphos-methyl. Numerous data gaps exist for
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azinphos-methyl. However, based on available data the Agency
has reached the following conclusions. A detailed discussion
of the points summarized below appears in Section B.
1. Azinphos-methyl is acutely toxic to humans via oral and
dermal routes of exposure. The toxicity is manifiested as
cholinesterase inhibition. Technical azinphos-methyl is
classified as Toxicity Category I due to oral and dermal toxicity.
Exposure can be reduced through imposition of protective measures
including protective clothing requirements, restricted use
classification, precautionary labeling, reentry intervals.
2. Valid data are not available at the present time to
assess the potential of azinphos-methyl to cause oncogenic,
teratogenic, or reproductive effects. Additional chronic data
are .required and further evaluation will be conducted.
3. Azinphos-methyl is acutely toxic to fish and wildlife.
Until required data are developed and submitted, hazards can be
reduced through labeling statements and restrictions to protect
potentially exposed endangered species.
As a result of this review the Agency has identified data
necessary to fully evaluate the human and environmental risks
associated with the use of azinphos-methyl. These data must be
developed in order to maintain registrations of products or
register new products containing azinphos-methyl. A summary of
these data gaps appears in Figure I. Please note that this is
only a summary and complete details can be obtained by referring
to the tables in Appendix I.
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The Agency has also determined that certain label restrictions
or revisions are necessary. These include:
Restricted Use Classification
Protective Clothing
Rotational Crop Restrictions
Reentry Intervals
Endangered Species Requirements
The Regulatory Position and Rationale section discusses the
Agency's position on each of these restrictions and the Required
Labeling section contains the specific language for each labeling
requirement.
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Figure 1- DATA GAP TABLE
Please refer to the tables in Appendix I for detailed
information regarding these requirements)
Toxicology
Technical Azinphos methyl
Acute Inhalation (Rat)
Delayed Neurotoxicity (Hen)
Chronic Toxicity (Rodent)
Oncogenicity (Rat)
Teratogenicity (Rat and Rabbit)
2 Generation Reproduction (Rat)
Mutagenicity Testing
General Metabolism Testing
Manufacturing Use Products
Acute Oral (Rat)
Acute Dermal (Rabbit)
Acute Inhalation (Rat)
Primary Eye Irritation (Rabbit)
Primary Dermal Irritation (Rabbit)
Dermal Sensitization (Guinea Pig)
End Use Products
Acute Inhalation
Acute Dermal
Environmental Fate/Exposure
-Re-entry
Foliar Dissipation
Soil Dissipation
Dermal Exposure
Inhalation Exposure
Special Testing - Glove Permeability
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Photodegradation (Water & Soil)
Anaerobic Aquatic Metabolism Study*
Forestry Dissipation*
Rotational Crops (Confined)
Irrigated-Crops Accumulation Study*
Accumulation in Non-target Organisms*
Ecological Effects
Acute Avian Oral Toxicity
Wild Mammal Toxicity
Avian Reproduction
Field Testing for Mammals & Birds
Acute Toxicity to Freshwater Invertebrates
Acute Toxicity to Estuarine and Marine
Organisms
Fish Early Life Stage
Simulated or Actual Field Testing for Aquatic Organisms
Honey Bee Toxicity (residues on foliage)
Product Chemistry/Residue Chemistry
Product Chemistry
Plant & Animal Metabolism
Storage Stability
Residue Studies
(Refer to Appendix I for Specified Crops)
* Data not needed ,if label clarifications are made.
(Refer to Appendix I for further information).
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B. PRELIMINARY RISK ASSESSMENT
The Agency has reviewed azinphos-methyl data in the areas of acute
toxicity, chronic toxicity, oncogenicity, reproductive effects,
mutagenicity, environmental fate and exposure, and ecological
effects. Numerous data gaps exist. The following assessment is
based on ctvdildble data and is subject to change when the results
of the required studies are available for Agency Review.
1. Acute Toxicity
All liquid formulations at concentrations of greater than 13.5%
were restricted to certified applicators in 1978. The pesticide
Incident Monitoring System (PIMS) data and California data on human
toxicity demonstrate the need for continued restriction of liquid
formulations .
Based on available acute oral and dermal toxicity data, technical
azinphos-methyl is classified as a Toxicity Category I chemical.
Available acute data define the approximate LDsgs for both oral and
dermal routes of exposure. The acute oral LD5Q for male and female
rats is 4.6 mg/kg and 4.4 mg/kg, respectively. Acute dermal LD5Q
values for rats range from 200 to 250 mg/kg for males and 155
mg/kg for females. The toxicity is manifested as cholinesterase
inhibition.
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There are several testing categories for which data are not
available for the technical and formulated products. (Refer
to Appendix I. for the product specific data requirement).
The Agency is requiring data to satisfy these testing
requirements and to determine appropriate labeling.
Acute human toxicity from azinphos-methyl was further evaluated
by reviewing reports of deaths, hospitalizations and visits to
physicians outside hospitals, from the PIMS reports and. from the
state of California.
The PIMS file, at the time of the search, contained 46,421
incident reports covering the period from 1966 to July 1981 (when
PIMS was discontinued), with 230 incidents involving the use of
azinphos-methyl.
Two groups of reports were distinguished. One group of
106 reports cited azinphos-methyl alone. The other group of
124 reports cited azinphos-methyl in combination with other
ingredients.
Humans were involved in 71 incidents in which azinphos-methyl
alone was cited as causing the alleged adverse effects. (These
incidents may have involved one or more persons). Seven people
were hospitalized, 102 received medical attention, and 12
were affected or involved but did not seek medical advice.
In the 84 incidents involving humans in which azinphos-methyl
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was cited in combination with other ingredients, there was 1
fatality (confirmed suicide) , 29 people were hospitalized, more
than 285 received medical attention and more than 27 were affected
or involved and did not seek medical advice. An additional
fatality, that may also be attributed to azinphos-methyl
exposure, occurred in 1985 as the result of pesticide missue.
The presentation of information regarding incident exposure,
circumstances and effects in PIMS reports is made with no
reference to whether or not the occurrence has been confirmed to
be the result of pesticide involvement.
During the period from 1966 to 1981, mixing, loading, spraying,
flagging, and handling the pesticide comprised about 40 percent
of the reported incidents where medical attention was received.
In several cases, other pesticides were also listed. Since
1978 (when liquid formulations containing greater than 13.5%
active ingredient were classified for restricted use) less
than 10% of the incidents where medical attention was received
involved mixers, loaders or applicators who reportedly used
proper protective clothing and equipment. A variety of
o'ther incidents involving medical attention was reported as
the result of accidents (17%); improper use, storage or
safety equipment (6%); spray drift (21%); and reentry (6%)
during the 1978-81 period reported from PIMS.
In addition to PIMS reports, the Agency reviewed data provided
by California (the only state which enforces manditory reporting
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of occupational pesticide incidents). Based on these data,
physicians treated an average of 5 azinphos-methyl poisonings
each year from 1981 through 1985. An additional one case per
year was reported as either skin or eye injury. Of the total 29
illnesses reported in this period, 10 involved applicators, 5
involved mixer-loaders, 7 were due to spray drift, 5 were due to
exposure co field residues, and 2 were due to other causes.
Between 1981 and 1985, five cases of occupational azinphos-methyl
poisoning required that the patient be hospitalized.
The PIMS record and California data demonstrate that systemic
poisoning to users can result from exposure to azinphos-methyl.
The Agency is relying on these data to form a regulatory
position to reduce exposure by continuing the restricted use
classification and by imposing protective clothing requirements.
2. Chronic Toxicity
Cholinesterase inhibition is the most significant toxic effect
identified with azinphos-methyl usage. A chronic feeding
study in dogs showed Cholinesterase as the primary toxic
action of azinphos-methyl. In this study, four groups of 4
dogs each per sex were offered diets containing azinphos-methyl
on a time weighted average as follows: 0 ppm (control); 5
ppm, 39.7 ppm, 135.7 ppm. Clinical signs appearing in
high dose animals, included muscle tremors, drooping of the
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head, and staggering. The No Observed Effect Level (NOEL) in
this study was 5ppm. No tumors were reported in any animals.
A chronic feeding study is required in rats.
3. Oncogenic Effects
In an oncogenicity bioassay performed by the National Cancer
Institute at Gulf South Research Institute, azinphos-methyl was
administered in the diet of Osborne-Mendel rats. Two groups of
50 male rats each received either 78 or 156 ppm for 80 weeks.
Two groups of 50 female rats each received either 62.5 or 125 ppm
for 80 weeks. Concurrent control groups consisted of 10 animals
per sex each. All animals were observed for an additional 34-35
weeks. Neoplasms of the thyroid gland and of the pancreas
suggested, but did not provide sufficient evidence to conclude
that azinphos-methyl is oncogenic to male Osborne-Mendel rats.
(Because of the wide range of spontaneous incidence of the thyroid
and pancreatic tumors in Osborne-Mendel rats, the Agency concluded
that there is no clear link between the deveopment of tumors to
the administration of azinphos-methyl). This study was judged
to be inadequate for statistical evaluation of risk because
only 10 concurrent control animals per sex were used. Additionally,
the use of pooled control animals, as used in this study, was
inadequate for comparison purposes because of the variation in the
experimental conditions under which animals were studied. A
valid rat study meeting guideline requirements is required to
determine the oncogenic potential of azinphos-methyl. Azinphos-methyl
was not shown to be oncogenic in female Osborne-Mendel rats in
this study.
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An acceptable mouse oncogenicity study, run concurrently by NCI
with the Osborne-Mendel rat study as discussed above, used 50
male and 50 female B6C3F1 mice. Male mice received dietary
doses of 31.3 or 62.5 ppm and female mice received dietary
doses of 62.5 or 125 ppm for 80 weeks. A concurrent control
group consisted of ten mice of each sex and a pooled control
group consisted of_130 males and 120 females. The animals were
observed for an additional 13 weeks. The test results demonstrated
that no incidence of tumors could be attributed to azinphos-methyl
exposure.
A new mouse study conducted by Mobay Chemical Corporation, which
is undergoing Agency evaluation, indicates that azinphos-methyl
was negative for oncogenicity in CDl mice. Azinphos-methyl was
fed to groups of 50 male and 50 female mice at doses of 0, 5, 20
and 40 ppm for two years. The Agency's preliminary review indicates
that no statistically significant increase in tumor incidence
could be attributed to ingestion of azinphos-methyl. Survival
rates were similar for all groups. There was no azinphos-methyl
related effect except that of cholinesterase inhibition.
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4. Human Exposure
Environmental Health Directorate, Health and Welfare Canada
has provided the Agency with azinphos-methyl human exposure
monitoring studies (GS0235057) conducted under their supervision.
The Canadian studies involved foliar application of an azinphos-
methyl 50% wettable powder formulation in orchards in British
Columbia, Ontario, and Nova Scotia. The 23 study participants
who mixed, loaded and applied the chemical wore cotton pants,
long-sleeved shirts, cotton coveralls, respirators and protective
gloves.
Urine samples were taken for 72 hours post-application and
analyzed for dimethylthiophosphate (DMTP), the primary urinary
metabolite of azinphos-methyl. The levels of urinary DMTP were
significantly correlated with amount of azinphos-methyl mixed
and sprayed. The overall mean internal dosage based on the
23 replicates was 1.2 mg azinphos-methyl per kilogram of
of active ingredient handled.
Usage data indicate that during typical orchard use as a foliar
insecticide, users may handle from 7.5 to 17.5 pounds
of azinphos-methyl active ingredient per day in the United States
Based upon these data, the daily dosage received during mixing,
loading, and application will range from 0.058 to 0.14 mg/kg/day
(based on a 70 kg individual), assuming the use of protective
gloves and cotton coveralls, but not respirators.
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Foliar and soil dissipation, and dermal and inhalation exposure
reentry data are required to fully access reentry exposure. A
glove permeability study is required for the liquid formulation
and the most concentrated spray solution using the wettable
powder formulation. The glove permeability study must conform to
"Standard Test Method for Resistance of Protective Clothing
Materials to Permeation by Hazardous Liquid Chemicals" by the
American Society for Testing and Materials.
5. Ecological Effects
Birds
Available acute oral avian toxicity studies are considered
supplemental because they do not follow Agency guidelines for
minimum numbers of dosage levels, for minimum numbers of birds
per species, and for many other current test requirements. These
data indicate that azinphos-methyl is moderately toxic to several
avian species when administered orally in a single dose. The
LD5Q values are as follows: Mallard Duck = 136 mg/kg, Bobwhite
Quail = 60-120 mg/kg, Pheasant = 74.9 mg/kg, and
Chukar partridge = 84.2 mg/kg.
Avian dietary toxicity studies demonstrate the variable
toxicity of azinphos-methyl. Azinphos-methyl is "highly toxic"
to bobwhite quail (LC$Q = 488 ppm), "moderately toxic" to
Japanese quail (LC5Q = 639 ppm), and "slightly toxic" to
ring-necked pheasant (LC^Q = 1821 ppm), and mallard duck
= 1940ppm).
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Based on theoretical calculations azinphos-methyl may pose an
acute hazard to birds, particularly at high application
rates. The Agency is requiring additional acute oral toxicity
testing, avian reproduction studies, and extensive field
monitoring to complete a hazard assessment.
Mammals
Available data on laboratory animals indicate that azinphos-
methyl is very highly toxic to mammals. The Agency lacks field
data to fully assess the acute toxicity of azinphos-methyl.
The Agency is requiring laboratory testing with wild mammals and
extensive field monitoring to complete a hazard assessment.
Aquatic 'Organisms
'Freshwater invertebrate acute toxicity data indicate that
azinphos-methyl is very highly toxic to all species tested
(LC5Q values range from 0.13 to 56 ug/ liter and species
tested include sowbug, amphipod, crayfish, glass shrimp, stonefly,
and daphnia).
Freshwater fish acute toxicty data indicate that azinphos-methyl
is very highly toxic to moderately toxic (LC5Q values range
from 0.36 to 4,270 ug/ liter), depending on species tested, with
most values in the very highly toxic range (less than 100 ug/1).
Exposure modeling for cotton, soybean, and apple use patterns showed
that aquatic residues could exceed levels acutely toxic to many
aquatic organisms. This could be expected for virtually all
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othec use sites as well, however, exposure modeling is not available
for all sites.
PIMS reports, covering the period from 1966 through 1981, were
reviewed to evaluate the extent of acute toxicity to freshwater fish
from field usage of azinphos-methyl. All fifteen reports of fish
kills, where azinphos-methyl alone was suspected, occurred prior
to 1974.
For the period 1978-1985, seven additional fish kills, citing
azinphos-methyl, alone, were obtained at the Agency's Office
of Water.
The Agency is requiring additional aquatic acute and chronic
toxicity testing as well as extensive aquatic field monitoring
to assess the extent of exposure and.hazard.
Wildlife Exposure and Hazard
Theoretical calculations and modeling indicate that azinphos-methyl
has the capacity to cause adverse effects to wildlife. The hazard
potential for any application rate appears to be greater for wild
mammals and aquatic organisms than for birds.
The Agency is requiring that extensive field monitoring studies
be conducted before risk assessment can be completed. Additionally,
the Agency has identified use patterns and endangered species
for which precautionary labeling is required. (Refer to Section
IV.D. for the designated species).
C. OTHER SCIENCE FINDINGS
1. Metabolism
There are no valid metabolism studies available. These data
are requi red.
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2. Reproductive/Teratogenic Effects
There are no valid reproduction or teratology studies available
to assess these effects from azinphos-methyl exposure. A
mouse reproduction study suggested that animals given 0, 5, 10,
or 25 ppm of azinphos-methyl showed no adverse effects over
three generations. However, this study was found to be invalid
due to reporting deficiencies and the Agency is requiring
reproductive and teratology studies.
3. Mutagenic Effects *
To assess the mutagenic potential of a chemical, the
Agency requires that the following tests be performed to address
the three categories of possible genetic effects :
(1) gene mutation, (2) chromosomal aberration and
(3) unscheduled DNA synthesis. No data are available on gene
mutation and chromosomal abberation. An acceptable unscheduled
DNA synthesis study demonstrated that azinphos-methyl does
not induce unscheduled DNA synthesis in rat hepatocytes.
4. Environmental Fate
Available data indicate that azinphos-methyl exhibits
low soil mobility and low leaching potential and, therefore, will
not pose a hazard from leaching to the groundwater. Field
dissipation studies demonstrate that azinphos-methyl is not
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persistent and 90% is degraded within 30 days. Under aerobic
conditions, azinphos-methyl breaks down in soil to a
azinphos-methyl oxygen analog, mercaptomethyl benzazimide,
benzazimide, hydroxlymethyl benzazimide, and bis-methyl
benzazimide sulfide.
The available data are insufficient to fully assess the
environmental fate of azinphos-methyl. Photodegradation and
rotational crops studies are required to be conducted and submitted
to the Agency. If label clarifications, as noted in Appendix I
(Table A) are made, additional data will not be required.
D. TOLERANCE REASSESSMENT
1. Tolerances issued.
Tolerances have been established for residues of
azinphos-methyl (per se) in a variety of raw agricultural comiuodi ties
in meat, fat and meat byproducts (refer to 40 CFR 180.154 and 40
CFR 180.154a for listing of tolerances), and in processed food
(21 CFR 193.150) and feed (21 CFR 561.180). No Mexican tolerances
have been established for azinphos-methyl.
Commod i t y
Alfalfa
Alfalfa, hay
Almonds
Almonds , hulls
Apples
Apricots
Artichokes
Barley, grain
Barley, straw
Beans( dry)
Beans( snap)
U.S.
2.0
5.0
0.3
10.3
2.0
2.0
2.0
0.2
2.0
0.3
2.0
Canadian
0.1
—
—
—
2.0
2.0
0.5
0.1
0.1
2.0
2.0
Codex
2.0
—
0.2
10.0
1.0
2.0
0.5
0.2
—
0.5
0.5
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24
Bicdsfoot Trefoil 2.0 0.1
BirdsfootTrefoil,hay 5.0 0.1
Blackberries ' 2.0 2.0 1.0
Blueberries 5.0 2.0 1.0
Boysenbecries 2.0 2.0 1.0
Broccoli 2.0 1.0 1.0
Brussels Sprouts 2.0 1.0 1.0
Cabbage 2.0 1.0 0.5
Cattle,fat 0.1
Cattle,meat by product 0.1
Cattle,meat 0.1
Cauliflower 2.0 0.5 0.5
Celery 2.0 0.5 2.0
Cherries 2.0 1.0 1.0
Citrus fruits 2.0 2.0 2.0
Clover 2.0 0.1
Clover,hay 5.0
Cottonseed 0.5 - 0.2
Crabapples 2.0 - 1.0
Cranberries 2.0
Cucumbers 2.0 0.5 0.5
Eggplant 0.3 - 0.5
Filberts 0.3
Goats,fat 0.1
Goats,meat by product 0.1
Goats,meat 0.1
Gooseberries 5.0
Grapes 5.0 5.0 4.0
Grass,pasture 2.0 0.1
Grass,pasture,hay 5.0
Horses,fat 0.1
Horses,meat by products 0.1
Horses,meat 0.1
Kiwi fruit , 10.0 0.4 4.0
Loganberries 2.0 2.0 1.0
Melons 2.0 - 2.0
Nectrines 2.0 - 1.0
Nat,Pistachio 0.3
Oats,grain 0.2 0.1 0.2
Oats,straw 2.0
Onions(green) 2.0 1.0 0.5
Parsley(leaves) 5.0 - 0.5
Parsley(roots) 2.0 - 0.5
Peaches 2.0 2.0 4.0
Pears 2.0 2.0 1.0
Peas,black-eyed 0.3 - 0.5
Pecans 0.3 - -
Peppers 0.3 0.2 0.5
Plums 2.0 1.0 1.0
Potatoes 0.3 0.1 0.2
Quinces 2.0 2.0 1.0
Raspberries 2.0 2.0 1.0
Rye,grain 0.2 0.1 0.2
Rye,straw 2.0 0.1
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25
Commodity U.S. Canadian Codex
Sheep, fat
Sheep, meat by product
Sheep, meat
Spinach
Strawberries
Sugarcane
Tomatoes
Walnuts
Wheat , grain
Wheat , straw
Milk
Soybean oil
Dried citruc
Sugarcane bagasse
Soybeans
2. Residue Data.
0
0
0
2
2
0
2
0
0
2
0
1
5
1
0
.1
.1
.1
.0
.0
.3
.0
.3
.2
.0
.04
.0
.0
.5
.2
—
-
-
2
1
-
1
0
0
0
-
-
-
-
0
.0
.0
.0
.1
.1
.1
.2
_
—
—
0
1
-
0
-
0
—
-
-
-
-
—
.5
.0
.5
.2
The residue data reviewed in support of these azinphos-methyl
tolerances are:
a. Data on the nature of the residues in both plants and
and animals, including identification of major metabolites
and degradates of azinphos-methyl. The available plant
metabolism data in which residues were most completely
identified are not adequate because characterization of
residues was conducted only in kidney bean plants. The
limited data do show that 14c-residues occur in untreated
shoot portions following foliar applications of 14^ azinphos-
methyl. Labelled residues are present in bean seedlings
germinated from 14c azinphos-methyl treated seed and in
shoots of beans following root exposure to hydroponic
solutions that contain 14C azinphos-methyl. The parent
compound, azinphos-methyl, azinphos-methyl oxon, dimethyl-
benzazimide sulfide, dimethyl benzazimide disulfide and
benzazimide have been identified in extracts of bean
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26
leaves.
Tolerances of azinphos-methyl ace currently expressed
as residues of azinphos-methyl per se. The nature of the
residue of azinphos-methyl in animals is not adequately
understood because the available data fail to characterize
total terminal residues in animal tissue. Upon receipt of
the required plant and animal data, the tolerance will
be reevaluated.
b. Analytical methodology for determining the
levels of residues of azinphos-methyl in plants and
animals is adequate for data collection for residues in
plant commodities and in animal tissues and milk. (If
additional metabolites of concern are found in plants
and animals, additional data may be required).
c. Storage stability data demonstrate that residues
of azinphos-methyl are stable in or on frozen plant
commodities for up to 72 weeks when stored at -18 to
-23°C, in milk samples stored at -23°C for up to 4 weeks
(azinphos-methyl and azinphos-methyl oxon), and in liver
samples stored at -22°C for up to 4 weeks (azinphos-methyl).
Residues of azinphos-methyl oxon are stable in liver samples
at -23°C for one week. Additional storage stability data
are required in order to evaluate the adequacy of numerous
established tolerances.
d. Data on the magnitude and levels of residues of
azinphos-methyl in individual raw agricultural
commodities, animal products, and processed food and
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27
feed items ace sufficient to determine the adequacy of the
established tolerances for residues of azinphos-methyl in
potatoes, parsley, pistachios, sugarcane and sugarcane
bagasse. There are not sufficient data available to
ascertain the adequacy of the established tolerances for
residues in or on onions, celery, spinach, broccoli, Brussels
sprouts, cabbage, cauliflower, beans, soybeans, peppers,
tomatoes, cucumbers, melons, citrus fruit, apples, apricots,
cherries, nectarines, peaches, plums, blackberries,
blueberries, cranberries, grapes, strawberries, almonds,
almond hulls, filberts, pecans, walnuts, wheat grain,
wheat straw, pasture grass, alfalfa, clove'r, artichokes,
cottonseed, kiwi fruit, eggplant, crabapples, pears,
quinces, boysenberries, loganberries, raspberries, oat
grain, rye grain, barley grain, oat straw, rye straw,
barley straw, birdsfoot trefoil, soybean oil, and
dried citrus pulp.
Because of the extensive residue chemistry data gaps, the
Agency cannot conduct a tolerance reassessment until the required
data are submitted and reviewed.
2. Toxicology
A 2-year rat feeding study with a NOEL of 5 ppm, based on
cholinesterase inhibition had originally been used to support the
established tolerances for residues of azinphos-methyl. Using
a ten-fold safety factor, the Acceptable Daily intake (ADI)
was calculated to be 0.0250 mg/kg/day (1 ppm in the rat diet is
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28
equivalent to 0.05 mg/kg/body weight/day), giving an MPI (Maximum
Permissible Intake) of 1.5 mg/day for a 60 kg person. The
Theoretical Maximum Residue Contribution (TMRC) for all published
tolerances was calculated to be 0.6678 mg/kg/day for a 1.5 kg
diet. The TMRC thus utilized 45.19% of the ADI. This study was
not acceptable to support registration, but may be upgraded upon
submission of additional information.
The Agency has, therefore, calculated a Provisional Limiting Dose
(PLD), which is similar to the ADI except that a greater safety
or "uncertainty" factor is used because the data base is now only
minimally adequate to support existing tolerances considering the
lack of the chronic rat study. The PLD is a temporary value that
is used until the data base is completed.
The PLD is based on a two year dog feeding study described earlier.
This' study demonstrated a NOEL of 5 ppm (1 ppm in the dog diet is
equivalent to 0.025 mg/kg/day) and uses an uncertainty factor of
100 (due to the effect of cholinesterase inhibition and the
reduced data base) . This yields a Maximum Permissible Intake
(MPI) of 0.075 mg/kg/day for a 60 kg person for a TMRC of 0.6678
mg/kg/day per 1.5 kg of diet.
The PLD is now 899% of the MPI. This value is greatly inflated
when compared to actual dietary residues expected in practice, and
is due solely to the additonal 10-fold uncertainty factor applied
for the reduced data base and the two-fold increase in sensitivity
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29
of the dog compared to that of the cat (i.e., l ppm
of a toxicant in the cat diet is equivalent to 2 ppm in the dog
diet) .
When additional chconic feeding studies necessacy to establish
an ADI ace submitted, the peccentage of the ADI utilized will be
adjusted and the uncectainty factocs may be eliminated as data
gaps ace filled. ~in addition, FDA cesidue monitocing data fcom
1978 to 1985 demonstcate that less than one peccent of the samples
taken fcom azinphos-methyl tceated ccops showed detectable cesidues
and all residue levels wece well below established tolecances.
The Agency concludes that the pcesent TMRC, which is a measuce
of the uppec limi't of possible dietacy exposure, is fac gceatec
than what is reasonably likely to be found in pcactice. Because
of the extensive residue chemistry and toxicology data gaps, the
Agency cannot conduct a full tolerance ceassessment. The tolecances
will be ceassessed when the cequiced data ace submitted and
reviewed.
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30
IV. REGULATORY POSITION AND RATIONALE
A. REGULATORY POSITIONS AND RATIONALES
Based on review and evaluation of all available data and other
relevant information on azinphos-methyl, the Agency has made the
following determinations:
1. The Agency is not placing azinphos-methyl into Special
Review at this time.
Rationale :
While the Agency has concerns for the hazard to both humans
and wildlife due to acute toxicity, the Agency is not initiating
a Special Review at this time.
For wildlife effects, theoretical calculations and modeling
indicate that azinphos-methyl has the capacity under various
use patterns and application rates to cause effects (i.e. non-target
mortality) to fish, birds and mammals. There is, however,
limited field data to support the finding that significant
adverse effects exist for terrestrial and aquatic wildlife.
The Agency is requiring extensive field monitoring data to
define the extent of exposure and hazard. Upon receipt and
review of the required data, the Agency will complete
a hazard assessment.
Incident data and human toxicity data on the technical product
demonstrate that systemic poisoning to users can result from
exposure to azinphos-methyl. Through the continued restricted
use classification for liquid formulations greater than 13.5%,
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31
the requirement of acute toxicity data to determine the appropriate
precautionary labeling for end-use products, and the imposition
of protective clothing and work safety statements, the Agency
believes that hazards posed by acute toxicity will be mitigated.
2. No significant new tolerances and significant new food
uses will be granted until the Agency has received data
sufficient to evaluate the dietary exposure to azinphos-methyl.
Rationale; The Agency is concerned that the PLD is now
899% of the MPI. Residue chemistry and toxicology data
bases for azinphos-methyl are not sufficient to assess the
exisiting tolerances. Plant and animal metabolism data and
residue data on various commodities are required. The pertinent
toxicology data requirements include: chronic feeding/oncbgenicity,
teratology, reproduction and mutagenicity. (Refer to Appendix
I, Table A, for a listing of residue chemistry and toxicology
data required). Until these data are submitted and reviewed,
the Agency cannot perform a tolerance reassessment.
3. The Agency will continue to restrict all liquid formulations
of azinphos-methyl with concentrations greater than 13.5% active
ingredient. In addition, registrants must either classify all
products for restricted use due to acute toxicity or submit
dermal and inhalation data to support the appropriate toxicity
category. (Note: The results of the data may indicate continued
restricted use classification).
Rationale: The restricted use classification was originally
imposed on all azinphos-methyl liquid formulations greater
than 13.5% due to inhalation toxicity. Because these data
are no longer acceptable, the Agency, in order
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32
to minimize risk to mixers, loaders, and applicators, will
continue to classify all liquid formulations of azinphos-methyl
with concentrations greater than 13.5% as restricted use
pesticides. Because of the number of reported incidents and
the, acute toxicity of technical azinphos-methyl, the Agency is
requiring data to determine the appropriate toxicity category
and precautionary labeling for all azinphos-methyl products.
Registrants may choose not to ^ubmit these data, in that
case, these products, will be classified as restricted use.
4. The Agency has classified azinphos-methyl as a class D
oncogen, meaning that there are inadequate data to determine
whether azinphos-methyl is an oncogen. A rat oncogenicity/chronic
feeding study and mutagenicity studies must be submitted. This
classification will be reevaluated when the required data
are submitted.
Rationale:
An NCI rat study was not conclusive regarding oncogenicity
boat indicated that azinphos-methyl may produce rare pancreatic
tumors and thyroid tumors in male rats. However, because
there were insufficient numbers of control animals, the
significance of these results is not known. Two separate
mouse studies were negative for oncogenic effects. Since
mutagenicity is an indicator of potential oncogenicity,
mutagenicity studies are being required.
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33
5. Endangered species labeling is cequiced foe certain
azinphos-methyl uses.
Rationale; Azinphos-methyl is toxic to certain fish, birds,
mammals and aquatic invertebrates which reside in areas
where azinphos-methyl is likely to be used. The Agency, in
an attempt to limit use of azinphos-methyl in areas where
its use may be detrimental to endangered species, is requiring
that endangered species information be included on labeling
of end-use products which contain certain uses for forests,
crops and range and pastureland. The required labeling is
based on Biological Opinions by the Office of Endangered
Species (OES) of the Fish and Wildlife Service, U.S. Department
of Interior. (Refer to Section IV. D. for the required
endangered species labeling).
6. A 24 hour reentry interval, as established in 1974 under
40 CFR 170.3(b)(2), will remain in effect. The Agency is
requiring reentry data (refer to Appendix A) to determine
the most effective reentry interval for azinphos-methyl.
Rationale;
Due to the Agency's continuing concern over the potential for
exposure to farmworkers reentering azinphos-methyl treated fields,
this interval will remain in effect. Based upon the evaluation
of the required data, the Agency may need to revise this reentry
interval.
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34
7. The Agency is imposing an interim crop (rotation restcriction of
6 months for root crops not registered for use with azinphos-methyl
and 30 days for all other crops not registered for use with
azinphos-methyl until the required crop rotation data are submitted.
Rationale; Agency files contain data that had reporting
deficiencies and did not follow Agency guidelines and were, therefore,
classified as supplemental data. These data indicate that no
residues of azinphos-methyl or azinphos-methyl oxygen analog
were detected in grain, pod and leafy vegetable crops that
were planted 30 days after azinphos-methyl applications.
Azinphos-methyl residues were detected in root crops planted
120 days after applications. Because these studies were not
carried out past 120 days, the Agency is imposing the 6 month
crop rotation restriction on root crops planted in azinphos-methyl
treated fields.
Until the required crop rotation data can be evaluated, the
Agency is imposing the crop rotation restrictions in order
to assure that excess residues of azinphos-methyl do not
occur in subsequently planted crops.
8. The Agency is requiring a glove permeability test for liquid
and wettable powder formulations of azinphos-methyl.
Rationale; Gloves can greatly reduce dermal exposure.
While gloves are required for handling azinphos-methyl,
there are no data demonstrating which materials best limit
exposure. The Agency is requiring the glove permeability
study in order to determine which materials are best suited
for this use.
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35
9. The Agency is requiring the addition of the telephone
number of the National Pesticide Telecommunications Network to
all azinphos-methyl products that ace classified as Toxicity
Category I and II (bearing the danger or warning signal
words).
Rationale; The telephone number is included in order to
provide a source of first aid information in the event of an
exposure accident.
10. The Agency is requiring that end-use product labeling
contain personal hygiene information and requirements for
cleaning of protective clothing and equipment after working
with azinphos-methyl products. (Refer to Section IV.D. for
specific labeling requirements).
Rationale; Because of the toxicity of many of these products
and the number of incidents reported, the Agency believes this
requirement is necessary to prevent poisonings of workers or
other household members through secondary exposure to contaminated
personal clothing.
11. The Agency is requiring that all azinphos-methyl end-use
product labeling must contain work safety rules, precautionary
statements, and protective clothing statements. (Refer to Section
IV.D. for specific labeling requirements).
Rationale; These precautionary labeling statments provide
specific guidance for persons handling azinphos-methyl products.
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36
These statements descci.be the required protective clothing and
equipment foe use, as well as procedures for minimizing exposure
to pesticide contaminated materials.
12. The Agency is prohibiting the use of human flaggers during
aerial application, unless they are in an enclosed vehicle.
Rationale: The Agency is imposing this requirement to minimize
hazard to flaggers because human flaggers face a risk of
exposure by direct contact or through drift during aerial
application.
13. While the required data are being developed, currently
registered manufacturing use products (MP's) and end use
products (EP's) containing azinphos-methyl as the sole active
ingredient may be sold, distributed, formulated and used
subject to the terms and conditions 'specified in this standard.
Registrants must provide or agree to develop and provide
additional data, as specified in the Data Appendices, in
order to maintain existing registrations.
Rationale; Under FIFRA, the Agency may choose not to cancel
or withhold registration if data are missing or inadequate
[see FIFRA Sec. 3(C)(2)(B) and 3(c)(7)]. The issuance of
this standard provides a mechanism for identifying data
needs. These data will be reviewed and evaluated, after
which the Agency will determine if additional regulatory
actions are necessary.
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37
B. CRITERIA FOR REGISTRATION
To be registered or reregistered under this standard, manufacturing
use products (MP) must contain azinphos-methyl as the sole active
ingredient, bear required labeling, and conform to the product
composition, acute toxicity limits, and use pattern requirements
listed in this document.
The applicant for registration or reregistration of manufacturing
use products subject to this standard must comply with all terms
and conditions described, including submission of an up-to-date
Confidential Statement of Formula, submission of revised labeling,
commitment to fill data gaps on the schedules as specified
by the Agency and, when applicable, offer to pay compensation as
required by sections 3 (c)(l)(D) and 3(c)(2)(D) of the
Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as
ameneded, 7 U.S.C. 136 (c)(2)(D). Registrants of end-use products
who qualify for the Formulator's Exemption must submit five (5)
copies of draft labeling incorporating the unique label statements
identified in Section D.
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38
C. ACCEPTABLE RANGES AND LIMITS
1. Product Composition Standard
To be registered or reregistered under this standard,
manufacturing-use products (MPs) must contain azinphos-methyl
as the sole active ingredient. Each MP formulation proposed for
registration must be fully described with an appropriate
certification of limits, stating maximum and minimum amounts
of the active ingredient and inert ingredients which are
present in products, as well as impurities found at greater
than 0.1%.
2. Acute Toxicity Limits
The Agency will consider registration of technical grade
and manufacturing products containing azinphos-methyl
provided that the product labeling bears appropriate
precautionary statements for the acute toxicity category in which
each product is placed.
3. Use Patterns
To be registered under this standard, manufacturing-use
products must be labeled for formulation into other
manufacturing-use products on into end-use products bearing
federally registered uses. The Use Index in Appendix III,
lists all registered uses, as well as approved maximum
application rates and frequencies.
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39
D. REQUIRED LABELING
All products must bear appropriate labeling as specified
in 40 CFR 162.10, PR Notice 83-2 and 83-3 and below. Appendix II
contains information on label requirements."
Pesticide products containing azinphos-methyl as an
active ingredient may not be released for shipment by the
registrant after October 31, 1987 unless the product bears
amended labeling which complies with the requirement of this
Standard.
Pesticide products containing azinphos-methyl as an
active ingredient may not be distributed, sold, offered foe-
sale, held for sale, shipped, delivered for shipment, or
received and (having been so received) delivered or offered to be
delivered by any person after October 31, 1988, unless the
product bears amended labeling which, approved by EPA,
complies with the requirements of this Standard.
The following information must appear on manufacturing
and end use products:
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40
Ingredients Statement
The ingredient statement for all azinphos-methyl
products must list the active ingredient as:
ACTIVE INGREDIENTS:
0,0-dimethyl-s-[(4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl]
phosphorodithioate %
INERT INGREDIENTS
Manufacturing Use Product Labeling
1 . Use Pattern Statements
All manufacturing-use products must state that they are
intended for formulation into end-use products for acceptable
use patterns. Labeling must specify sites, which are listed
in Use Patterns, Appendix III. However, no use may be included
on the label where the registrant fails to agree to comply with
the data requirements in TABLE A for that use pattern.
2 . Environmental Hazards statement
The following revised environmental hazard statement must
appear on all manufacturing-use product labels:
"This pesticide is extremely toxic to fish and wildlife.
Do not discharge effluent containing this product directly
into lakes, streams, ponds, estuaries, oceans or public
waters unless this product is specifically identified and
addressed in an NPDES permit. Do not discharge effluent
containing this product to sewer systems without previously
notifying the sewage treatment plant authority. For
guidance, contact your State Water Board or Regional Office
of the Environmental Protection Agency."
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41
End Use Product Labeling
a. Environmental Hazards Statements
"This pesticide is extremely toxic to fish and wildlife.
Do not apply directly to water or wetlands (swamps, bogs,
marshes, and potholes). Do not contaminate water by
cleaning of equipment or disposal of wastes. Drift and
runoff from treated areas may be hazardous to aquatic
organisms in neighboring areas."
For granular products add:
"Cover or incorporate granules that are spilled during
loading or are visible on soil surface in turn areas."
b. Endangered Species
The paragraph below must appear on all end-use product
labels that contain forest, crop, range and pasture-
land (east of Mississippi) uses:
"ENDANGERED SPECIES RESTRICTIONS
The use of any pesticide in a manner that may kill or
otherwise harm an endangered or. threatened species or
adversely modify its habitat is a violation of federal
laws. The use of this product is controlled to prevent
death or harm to endangered or threatened species that
occur in the following counties or elsewhere in their
range. Before using this pesticide in the following
counties you must obtain the EPA Crop and
Rangeland/Pastureland Endangered Species Bulletins.
The use of this pesticide is prohibited in these counties
unless specified otherwise in the Bulletins. The EPA
Bulletins are available from either your County Agricultural
Extension Agent, the Endangered Species Specialist in
your State Wildlife Agency Headquarters or the appropriate
Regional Office Headquarters or the appropriate Regional
Office of either the US Fish and Wildife Service (FWS)
or the US Environmental Protection Agency. THESE BULLETINS
MUST BE REVIEWED PRIOR TO PESTICIDE USE." ~
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42
In addition to the paragraph above, end use product
labeling must contain the following specific species listing and
location information for forest, crop and range and pastureland
(east of the Mississippi) uses:
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43
AZINPHOS-METHYL ENDANGERED SPECIES LABEL INFORMATION FOR FOREST USES
ENDANGERED SPECIES RESTRICTIONS
STATE (regional office FWS)
Species
ALABAMA (Atlanta, GA.)
Red-cockaded woodpecker
Slackwater darter
Snail darter
Freshwater mussels
COUNTY
Baldwin, Bibb, Calhoun, Chilton, Clay
Cleburne, Covington, Escambia, Dale,
Jefferson, Lawrence, Macon, Perry, Shelby,
St. Clair, Talladega, Tuscaloosa and Winston
Lauderdale, Limestone and Madison
Jackson and Madison
Colbert, Jackson, Marshall and Morgan
ARIZONA (Albuquerque, N.M.)
Arizona (Apache) trout
Gila trout
Bonytail chub
Apache, Greenlee and Graham
Cochise, Santa Cruz, Pinal, Graham and Pima
Mohave
ARKANSAS (Atlanta, GA.)
Freshwater mussels
Red-cockaded woodpecker
Clay, Clark, Cross, Lawrence, Randolph, Sharp
and St. Francis
Ashley, Calhoun, Clark, Columbia, Hempstead,
Lafayette, Monroe, Ouachita, Pol.k, Scott
and Union
CALIFORNIA (Portland, OR.)
Little Kern golden trout
Paiute cutthroat trout
Tulare
Alpine, Madera and Mono
COLORADO (Denver, CO.)
Greenback cutthroat trout
Bonytail chub |
Humpback chub >
Colorado Squawf ish |
Boulder, Larimer, Gilpin, Park and Fremont
Routt, Moffat, Rio, Blanco, Garfield,
Mesa and Delta
FLORIDA (Atlanta, GA.)
Red-cockaded woodpecker
Alachua, Baker, Bay, Brevard, Charlotte,
Citrus, Clay, Columbia, Duval, Franklin,
Glades, Gulf, Hernando, Highlands, Lee, Leon,
Levy, Liberty, Marion, Martin, Okaloosa,
Okeechobee, Osceola, Palm Beach, Pasco,
St. Johns, Santa Rosa, Wakulla and Walton
Okaloosa darter
Okaloosa and Walton
-------
Forest Use (continued)
STATE
Species
COUNTY
GEORGIA (Atlanta)
Red-cockaded woodpecker
Snail darter
Appling, Baldwin, Brantley, Charlton,
Chattahoochee, Clarke, Clinch, Decatur, Floyd
Glynn, Grady, Harris, Jasper, Jenkins, Jones,
Pierce, Putnam, Screven, Tattnall, Telfair,
Thonias, Toonbs, Turner, Ware, Washington
and Wilkes
Catoosa
KENTUCKY (Atlanta, GA.)
Freshwater mussels
Red-cockaded woodpecker
Ballard, Edmundson, Jackson, Laurel, Marshall
McCracken, Pulaski, Rockcastle, Warren
and Wayne
Laurel and McCreary
LOUISIANA (Atlanta, GA.)
Red-cockaded woodpecker
Allen, Beauregard, Bienville, Bossier, Caddo,
Calcasieu, Catahoula, Claiborne, Grant,
La Salle, Morehouse, Natchitoches, Ouachita,
Rapides, St. Tammany, Tangipahoa, Union,
Vernon and Washington
4ARYLAND (Newton Corners, MA.
Red-cockaded woodpecker
Maryland darter
Dorchester
Harford
-SICHIGANJ Twin Cities, MM.)
Kirtland's warbler
Crawford, Kalkaska, Oscoda, Ogemaw,
Roscommon and Wexford
MISSISSIPPI (Atlanta, GA.)
Red-cockaded woodpecker
Choctaw, Copiah, Franklin, Harrison, Hinds,
Jackson, Jones, Lauderdale, Leake, Madison,
Marion, Noxubee, Oktibbeha, Pearl River,
Scott, Smith, Stone, Wayne, Wilkinson and
Winston
MORTH CAROLINA (Atlanta, GA.)
Red-cockaded woodpecker
Spotfin chub
Beaufort, Bertie, Bladen, Brunswick,
Cumberland, Gates, Harriett, Hertford, Hoke,
Hyde, Jones, Montgomery, Moore, Northampton,
Onslow, Pamlico, Perquimans, Pitt, Richmond,
Wake and Wayne
Macon and Swain
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45
Forest Use (continued)
STATE
Species
COUNTY
OKLAHOMA (Albuquerque, N.M.)
Red-cockaded woodpecker
Leopard darter
Bryan, Latimer, Le Flore, MeCurtain, Pittsburg
and Pushmataha
Pushmataha and MeCurtain
OHIO (Twin Cities, MM.)
Scioto madtcm
Champagne, Franklin, Logan, Madison*
Pikaway and Union
SOUTH CAROLINA (Atlanta, GA.)
Red-cockaded woodpecker
Aiken, Barnwell, Beaufort, Berkeley, .Calhoun,
Charleston, Chesterfield, Clarendon, Colleton,
Darlington, Dillon, Dorchester, Edgefield,
Florence, Georgetown, Hampton, Horry, Laurens,
Lee, Lexington, Orangeburg, Richland, Sunter
and Williamsburg
TENNESSEE (Atlanta, GA.)
Freshwater mussels
Red-cockaded woodpecker
Slackwater darter
Slender chub
Spotfin chub
Snail darter
Yellowfin madtcm
Blount, Claiborne, Decatur, Franklin, Hancock,
Hardin, Lincoln, Loudon, Marshall, Maury, Rhea,
Roane, Scott, Sequatchie, Smith and Sullivan
Blount, Campbell, Cumberland and Morgan
Lawrence and Wayne
Claiborne and Hancock
Qmberland, Fentress and Morgan
Loudon, Meigs, Polk,-Hamilton, Marion,
Bradley and Knox
Claiborne, Hancock and Monroe
TEXAS (Albuquerque, N.M.)
Red-cockaded woodpecker
Angelina, Cass, Cherokee, Hardin, Houston,
Jasper, Montgomery, Nacogdoches, Newton,
Polk, Sabine, San Augustine, San Jacinto,
Shelby, Trinity, Tyler and Walker
UTAH (Denver, CO.)
Bonytail chub
Humpback chub
Colorado squawfish
Carbon, Duchesne, Emery, Garfield,
Uintah, Grand, Kane, San Juan and
Wayne
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46
Forest Use (continued)
STATE
Species
VIRGINIA (Newton Corners, MA.
Freshwater mussels
Red-cockaded woodpecker
Slender chub
Spotfin chub
Yellowfin madtom
COUNTY
Lee, Russell, Scott, Smyth, Tazewell,
Washington and Wise
Prince George, Southampton, Surry and
Sussex
Lee and Scott
Scott and Washington
Lee, Scott and Russell
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47
AZINPHOS-METHYL ENDANGERED SPECIES LABELING INFORMATION FOR CROP USES
STATE (Regional office FWS)
Species
ALABAMA (Atlanta, GA.)
Slackwater darter
Alabama cave fish
Freshwater mussels
ARIZONA (Albuquerque, N.M.)
Wbundfin
Gila topminnow
ARKANSAS ( Atlanta, GA. )
Freshwater mussels
Leopard darter
CALIFORNIA (Portland, OR.)
Delta green ground beetle
Valley elderberry
longhorn beetle
Aleutian Canada goose
Kern primrose sphinx moth
American peregrine falcon
Blunt-nosed leopard lizard
Santa Cruz long-toed
salamander
Unarmored three-spine
stickelback
COLORADO (Denver, CO.)
Colorado squawfish
KENTUCKY (Atlanta, GA. )
Freshwater mussels
MICHIGAN (Twin Cities, MM.)
American peregrine falcon
COUNTY
LAUDERDALE
LIMESTONE
MADISON
LAUDERDALE
COLBERT
JACKSON
MARSHALL
MORGAN
MOHAVE
GRAHAM
CLAY
CLARK
CROSS
LAWRENCE
SANTA CRUZ
RANDOLPH
SHARP
ST. FRANCIS
POLK
SOLANO
MERCED
SACRAMENTO
COLUSA
MERCED
SUTTER
STANISLAUS
KERN
HUMBOLT
LOS ANGELES
MARIPOSA
MENDOCINO
MONTEREY
SAN DIEGO
FRESNO
KERN
KINGS
MADERA
MERCED
MONTEREY
LOS ANGELES
BLANCO
DELTA
GARFIELD
MESA
BALLARD
EDMUNDSON
JACKSON
LAUREL
MARSHALL
SAN LUIS OBISPO
SAN MATED
SANTA CLARA
SANTA CRUZ
SONOMA
TUOLUMNE
MONTEREY
SAN LUIS OBISPO
SANTA BARBARA
STANISLAUS
TULARE
SANTA CRUZ
SANTA BARBARA
MOFFAT
RIO
ROUTT
McCRACKEN
PULASKI
ROCKCASTLE
WARREN
WAYNE
LEEVANAU
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Crop Uses (continued)
48
MINNESOTA (Twin Cities, MM.)
American peregrine falcon CHISAGO
DAKOTA
GOODHUE
HOUSTON
mSASHA
^SHINGTON
WINONA
MISSISSIPPI (Atlanta, GA. ) CLAIBORNE
Bayou darter COPIAH
NEVADA (Portland, OR.)
Woundfin CLARK
Pahranagat bonytail LINCOLN
Cui-ui WASHOE
Pahrump killifish CLARK
NEW MEXICO (Albuquerque, N.M.)
Pecos g ambus i a
OHIO (Twin Cities, MN.)
Scioto mad ton
OKLAHOMA (Albuquerque, N.M.)
Leopard darter
OREGON (Portland, OR.)
American peregrine falcon
TENNESSEE (Atlanta, GA. )
Slackwater darter
Freshwater mussels
TEXAS (Albuquerque, N.M.)
Attwater's Greater
Prairie Chicken J
Conmanche Springs
_pupf ish
Pecos gambusia
Texas blind salamander
San Marcos salamander
San Marcos gambusia
Houston toad
Fountain darter
WHITE PINE
CHAVES
EDDY
CHAMPAGNE
FRANKLIN
LOGAN
MADISON
PICKAWAY
UNION
LEFLORE
MCCURTAIN
CLACKAMUS
DOUGLAS
HOOD RIVER
JACKSON
MARION
UMATILLA
WASCO
LAWRENCE
WAYNE
BLOUNT
CLAIBORNE
DECATUR
FRANKLIN
HANCOCK
HARDIN
LINCOLN
LOUDON
ARANSAS
AUSTIN
COLORADO
FORT BEND
MARSHALL
MAURY
RHEA
ROANE
SCOTT
SEQUATCHIE
SMITH
SULLIVAN
GOLIAD
REFUGIO
VICTORIA
JEFF DAVIS
REEVES
JEFF DAVIS
PECOS
REEVES
HAYS
COMAL
HAYS
HAYS
BASTROP
BURLESON
COMAL
HARRIS
HAYS
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Crop Uses (continued)
49
UTAH (Denver, CO.)
Woundfin
Colorado squawfish
VIRGINIA (Newton Comers, MA.)
Freshwater mussels
WASHINGTON (Portland, OR.)
American peregrine falcon
WISCONSON (Twin Cities, MM.)
American peregrine falcon
WASHINGTON
CARBON
DUCHESNE
EMERY
GARFIELD
GRAND
LEE
RUSSELL
SCOTT
SMYTH
KANE
SAN JUAN
UINTAH
WAYNE
TAZEWELL
WASHINGTON
WISE
SKAMANIA
CRAWFORD
DANE
DOOR
RICHLAND
SAUK
TREMPEALEAU
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50
AZINPHOS-METHYL LABELING INFORMATION FDR RANGE AND PASTURELAND USES EAST OF
MISSISSIPPI
STATE (Regional Office FWS)
Species
County (unless specified otherwise)
ALABAMA (Atlanta, GA. )
Alabama cave fish
Slackwater darter
Snail darter
Watercress darter
Freshwater mussels
ARKANSAS (Atlanta, GA. )
Freshwater mussels
FLORIDA (Atlanta, GA.)
Okalcosa darter
Eastern indigo snake
GEORGIA (Atlanta, GA. )
Snail darter
Eastern indigo snake
KENTUCKY (Atlanta, GA.)
Freshwater mussels
Kentucky Cave shrimp
MARYLAND (Newton Corners, MA.)
Maryland darter
MISSISSIPPI (Atlanta, GA.)
Bayou darter
Mississippi sandhill crane
NORTH CAROLINA (Atlanta, GA. )
Spotfin chub
OHIO (Twin Cities, MN.)
Scioto Madtorn
Lauderdale
Lauderdale, Limestone and Madison
Jackson and Madison
Jefferson
Colbert, Jackson, Marshall and Morgan
and Monroe
Clark, Clay, Cross, Lawrence, Randolph,
Sharp and St. Francis
Okalcosa and Walton
Statewide
Catoosa
S.E. Georgia
Ballard, Edmundson, Jackson, Laurel,
Marshall, McCracken, Pulaski, Rockastle,
Warren and Wayne
Edmundson and Hart
Harford
Claiborne and Copiah
Jackson
Macon and Swain
Chanpagne, Franklin, Logan, Madison,
Pickaway and Union
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51
Range and Pastureland (continued)
TENNESSEE (Atlanta, GA.)
Slender chub
Spotfin chub
Slackwater darter
Snail darter
Yellowfin madtcm
Freshwater mussels
Claiborne and Hancock
Cumberland, Fentress and Morgan
Lawrence, Wayne,
Bradley, Hamilton, Knox, Loudon,
Marion, Meigs and Polk
Claiborne, Hancock and Monroe
Blount, Claiborne, Decatur, Franklin,
Hancock, Hardin, Hawkins, Lincoln,
Loudon, Marshall, Maury, Rhea, Roane,
Scott, Sequatchie, Smith and Sullivan
1RGINIA (Newton Corners, MA.)
Slender chub
Spotfin chub
Yellowf in madton
Freshwater mussels
Lee and Scott
Scott and Washington
Lee, Russell and Scott
Lee, Russell, Scott, Smyth, Tazewell,
Washington and Wise .—
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c. Reentry Statement
The following statement must appear on the labeling
of agricultural end use pcoducts which ace applied to ccops
whose culture may involve hand labor tasks:
"Do not enter treated areas for 24 hours after application
unless protective clothing is worn, as described in the
product labeling."
d. ' Restricted Use Statement
The following restricted use statement must appear on
the front panel of all end-use labeling for liquid formu-
lations with concentrations greater than 13.5%:
"RESTRICTED USE PESTICIDE
Due to acute toxicity
For retail sale to and use only by certified applicators
or persons under their direct supervision and only
for those uses covered by the certified applicator's
certification".
As stated in Section IV. A., registrants of all azinphos-methyl
end-use products will be given the option of either submitting
acute toxicity' data (refer to Appendix A for listing of data
requirements) or restricting their products and revising their
label(s) to include the restricted use statement above and the
following precautionary language associated with Toxicity Category
I products:
"Danger
Fatal if swallowed, inhaled or absorbed through the skin.
Do not breath vapor, dust or spray mist. Do not get in eyes,
on skin, or on clothing."
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e. Rotational Crop Statement
All end-use products must have the following crop
rotation statement:
"Do not plant coot crops other than those with
registered azinphos-methyl uses in azinphos-methyl
treated soil sooner than 6 months after the last
application. Do not plant any other ccop
other than those with registered az-inphos-methyl
uses in treated soil sooner than 30 days after
last applications".
f. Work Safety Rules
"If handled indoors provide mechanical exhaust venti-
lation.
Keep all unprotected persons, children'", livestock, and
pets away from treated areas or where there is danger of
drift.
Do not cub eyes or mouth with hands. If you feel sick
in any way, STOP work and get help right away, see First Aid
section of the label.
For questions regarding further treatment, or information
about the product, call the National Pesticide
Telecommunications Network at 800-858-7378."
Protective Clothing and Work Safety Statements
for all azinphos-methyl End-Use products :
Labeling for Products with Danger and Warning Signal words
'HANDLE THE CONCENTRATE ONLY WHEN WEARING THE FOLLOWING
PROTECTIVE CLOTHING AND EQUIPMENT:
Wear a protective suit of one or two pieces that covers
all parts of the body except the head, hands, and feet.
Wear chemical resistant gloves, chemical resistant apron,
and chemical resistant shoes, shoe coverings, or boots.
Wear goggles or a face shield and a pesticide respirator
approved by the National Institute for Occupational Safety
and Health under the provisions of 30 CFR Part II.
If handling the concentrate with a closed system, long
sleeved shirt and long-legged pants may be substituted
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54
foe the pcotective suit, and the respirator cequi cement
is waived. (Foe liquid formulations only).
WEAR THE FOLLOWING PROTECTIVE CLOTHING DURING APPLICATION,
EQUIPMENT REPAIR, EQUIPMENT CLEANING, DURING REENTRY TO
TREATED AREAS, AND DISPOSAL OF THE PESTICIDE:
Wear a pcotective suit of one or two pieces that covers all
parts of the body except the head, hands, and feet. Wear
chemical resistant gloves and chemical resistant shoes,
shoe coverings, or boots. Wear a chemical resistant hat
during airblast application.
During application from an enclosed tractor cab or air-
plane cockpit, or other suitable vehicle in which the
windows are rolled up, long sleeved shirt and long pants
may be worn in place of the above protective clothing.
Chemical resistant gloves must be available in the cab or
cockpit and must be worn while exiting. This clothing is
inadequate to protect you during equipment repair,
equipment cleaning, re-entry, or during pesticide disposal.
IMPORTANT! BEFORE REMOVING GLOVES, WASH THEM WITH SOAP
AND WATER. ALWAYS WASH HANDS, FACE, AND ARMS WITH SOAP
AND WATER BEFORE SMOKING, DRINKING, EATING OR TOILETING.
After work, take off all clothing and shoes. Shower
using soap and water. Do not wear contaminated clothing.
Wash protective clothing and protective equipment with
soap and water after each use. Respirators must be cleaned
and filters replaced according to instructions included
with the respirators. Personal clothing worn during use
must be laundered separately from household articles.
Clothing and protective equipment heavily contaminated or
drenched with azinphos-methyl must be destroyed according
to state and local regulations. HEAVILY CONTAMINATED OR
DRENCHED CLOTHING CANNOT BE ADEQUATELY DECONTAMINATED.
During aerial application, human flaggers are prohibited
unless in totally enclosed vehicle".
h. protective Clothing and Work Safety statements for
End-Use Products that have "Caution" as the signal word;
"If handled indoors provide mechanical exhaust ventilation
Keep all unprotected persons, children, livestock, and
pets away from treated areas or where there is danger of
drift.
Do not rub eyes 'or mouth with hands. If you feel sick
in any way, STOP work and get help right away. See
First Aid (Practical Treatment) section of the label.
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55
When handling this product wear long pants and long
sleeved shirt. Wear chemical resistant gloves during
mixing and loading, equipment repair and cleaning, and
during reentry to treated areas before the reentry interval
has .expi red.
Important! Before removing gloves, wash them with soad
and water. Always wash hands, face, and arms with soap
and water before smoking, drinking, eating or toileting."
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V. PRODUCTS SUBJECT TO THIS STANDARD
All products containing one or more of the pesticides
identified in Section II.A. are subject to certain requirements
for data submission or changes in composition, labeling or
packaging of the product. The applicable requirements depend
on whether the product is a manufacturing or end use product
and whether the pesticide is the sole active ingredient or
one of multiple active ingredients.
Products are subject to this Registration Standard as
follows:
A. Manufacturing use products containing this pesticide as
the sole active ingredient are subject to:
1. The restrictions (if any) upon use, composition, or
packaging listed in Section IV, if they pertain to the
manufacturing use product.
2. The data requirements listed in Tables A and fi2
3. The labeling requirements specified for manufacturing
use products in Section IV.
4. Administrative requirements (application forms, Confiden-
tial Statement of Formula, data compensation provisions)
associated with reregistration.
2 Data requirements are listed in the three Tables in
Appendix I of this Registration Standard. The Guide to
Tables in that Appendix explains how to read the Tables.
Table A lists generic data requirements applicable to all
products containing the pesticide subject to this Registra-
tion Standard. Table B lists product-specific data applicable
to manufacturing use products. The data in Tables A and B
need not be submitted by a producer who is eligible for the
formulator's exemption for that active ingredient.
Table C lists product-specific data applicable to end use
products. The Agency has decided that, in most cases, it
will not require the submission of product-specific data for
end use products at this time. Therefore most Registration
Standards do not contain a Table C.
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57
B. Manufacturing use products containing this pesticide
as one of multiple active ingredients are subject to:
The data requirements listed in Table A and label requirements
C. End use products containing this pesticide as the
sole active ingredient* are subject to:
1. The restrictions (if any) upon use, composition, or
packaging listed in Section IV if they pertain to the
end use product.
2. If eligible for the formulator's exemption3, the
data requirements listed in Table C.
3. If not eligible for the formulator's exemption, the
data requirements listed in Table A and the data require-
ments listed in Table C.
4. The labeling requirements specified for end use
products in Section IV.
D. End use products containing this pesticide as one of
multiple active ingredients are subject to:
a. If not eligible for the formulator's exemption,
the date requirements listed in Tables A and C.
b. If eligible for the formulator's exemption, the
data requirements listed in Table C.
c. Labeling requirements specified for end use products.
3 If you purchase from another producer and use as the
source of your active ingredient only EPA-registered products,
you are eligible for the formulator's exemption for generic
data concerning that active ingredient (Table A) and product-
specific data for the registered manufacturing use product
you purchase (Table B).
Two circumstances nullify this exemption:
1) If you change sources of active ingredient to an
unregistered product, formulate your own active ingredient,
or acquire your active ingredient from a firm with ownership
in common with yours, you individually lose the exemption
and become subject to the data requirements in Table A.
2) If no producer subject to the generic data requirements
in Table A agrees to submit the required data, all end use
producers lose the exemption, and become subject to those
data requirements.
* Solvents or drluents must be declared as inerts. The Agency does
not have data indicating that these solvents are insecticidal.
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VI. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
This portion of the Registration Standard is a notice
issued under the authority of FIFRA sec. 3(c)(2)(B). It
refers to the data listed in Table A, which are required to
be submitted by registrants to maintain in effect the regis-
tration of products containing this active ingredient.4
A. What are generic data?
Generic data pertain to the properties or effects of a
particular active ingredient. Such data are relevant to an
evaluation of all products containing that active ingredient
regardless of whether the product contains other ingredients.
(unless the product bears labeling that would make the data
requirement inapplicable).
Generic data may also be data on a "typical formulation"
of a product. "Typical formulation" testing is often required
for ecological effects studies and applies to all products
having that formulation type. These are classed as generic
data, and are contained in Table A.
B. Who must submit generic data?
All current registrants are responsible for submitting
generic data in response to a data request under FIFRA sec.
3(c)(2)(B) (DCI Notice). EPA has decided, however, not to
require a registrant who qualifies for the formulator's
exemption (FIFRA sec. 3(c)(2)(D) and § 152.85) to submit
generic data in response to a DCI notice if the registrant
who supplies the active ingredient in his product is complying
with the data request.
If you are not now eligible for a formulator's exemption,
you may qualify for one if you change your source of supply
to a registered source that does not share ownership in
common with your firm. If you choose to change sources of
supply, the Confidential Statement of Formula must identify
the new source(s) and you must submit a Formulator's Exemption
Statement form.
If you apply for a new registration for products containing
this active ingredient after the issuance of this Registration
Standard, you will be required to submit or cite generic
data relevant to the uses of your product if, at the time
4 Registrations granted after issuance of this Standard
will be conditioned upon submission or citation of the data
listed in this Registration Standard.
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59
the application is submitted, the data have been submitted
to the Agency by current registrants. If the required data
have not yet been submitted, any new registration will be
conditioned upon the new registrant's submission or citation
of the required data not later than the date upon which
current registrants of similar products are required to provide
such data. See FIFRA sec. 3(c)(7)(A). If you thereafter fail
to comply with the condition of that registration to provide
data, the registration may be cancelled (FIFRA sec. 6(e))..
C. What generic data must be submitted?
You may determine which generic data you must submit by
consulting Table A. That table lists the generic data needed
to evaluate current uses of all products containing this
active ingredient, the uses for which such dataware required,
and the dates by which the data must be submitted to the
Agency.
D. How to comply with PCI requirements.
Within 90 days of your receipt of this Registration
Standard, you must submit to EPA a completed copy of the form
entitled "FIFRA Section 3(c)(2)(B) Summary Sheet" (EPA Form
8580-1, enclosed) for each of your products. On that form
you must state which of the following six methods you will
use to comply with the DCI requirements:
1. You will submit the data yourself.
2. You have entered into an agreement with one or more
registrants to jointly develop (or share in the cost of
developing) the data, but will not be submitting the data
yourself. If you use this method, you must state who will
submit the data on which you will rely. You must also provide
EPA with documentary evidence that an agreement has been
formed which allows you to rely upon the data to be submitted.
Such evidence may be: (1) your letter offering to join in
an agreement and the other registrant's acceptance of your
offer, (2) a written statement by the parties that an" agreement
exists, or (3) a written statement by the person who will be
submitting the data that you may rely upon its submission.
The Agency will also require adequate assurance that the
person whom you state will provide the data is taking appropriate
steps to secure it. The agreement to produce the data need
not specify all of the terms of the final arrangement between
the parties or a mechanism to resolve the terms.
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3. You have attempted to'enter into an agreement to
jointly develop data, but no other registrant has accepted
your offer. 'You request that EPA not suspend your registration
for non-compliance with the PCI. EPA has determined that,
as a general policy, it will not suspend the registration of
a product when the registrant has in good faith sought and
continues- to seek to enter into a data development/cost
sharing program, but the other registrants developing the
data have refused to accept its offer. [If your offer is
accepted, you may qualify for Option 2 above by entering
into an agreement to supply the data.]
In order to qualify for this method, you must:
1. File with EPA a completed "Certification of Attempt
to Enter into an Agreement with other Registrants for Develop-
ment of Data" (EPA Form 8580-6, enclosed).
2. Provide us with a copy of your offer to the other
registrant and proof of the other registrant's receipt of your
offer (such as a certified mail receipt). Your offer must,
at a minimum, contain the following language or its equivalent:
[Your company name] offers to share in the burden of
producing the data required pursuant to FIFRA sec.
3(c)(2)(B) in the [name of active ingredient] Registration
Standard upon terms to be agreed or failing agreement
to be bound by binding arbitration as provided by FIFRA
section 3(c)(2)(B)(iii) .
The remainder of your offer may not in any way attempt to
limit this commitment. If the other registrant to whom your
offer is made does not accept your'offer, and if the other
registrant informs us on a DCI Summary Sheet that he will
develop and submit the data required under the DCI, then you
may qualify for this option. in order for you to avoid
suspension under this method, you may not later withdraw or
limit your offer to share in the burden of developing the
data. In addition, the other registrant must fulfill its
commitment to develop and submit the data.
4. You request a waiver of the data requirement. If
you believe that, a data requirement does not (or should not)
apply to your product or its uses, you must provide EPA with
a statement of the reasons why you believe this is so. Your
statement must address the specific composition or use factors
that lead you to believe that a requirement does not apply.
Since the Agency has carefully considered the composition and
uses of pesticide products in determining that a data require-
ment applies, EPA does not anticipate that many waivers will
be granted. A request for waiver does not extend the time-
frames for developing required data, and if your waiver
request is denied, your registration may be suspended if you
fail to submit the data.
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5. You request that EPA amend your registration by deleting
the uses for which the data are needed. You are not required
to submit data for uses which are no longer on your label.
6. You request voluntary cancellation of the registration
of your product(s) for which the data are needed.
E. Procedures for requesting a change in testing protocol.
If you will generate the required data and plan to use
test procedures which deviate from (or are not specified in)
either EPA's Pesticide Assessment Guidelines or the Reports
of Expert Groups to the Chemicals Group, Organization for
Economic Cooperation and Development (OECD) Chemicals Testing
Programme, you must submit for EPA approval the protocols
you propose to use.
You should -submit your protocols before beginning testing
and await EPA approval, because the Agency will not ordinarily
accept as sufficient studies using unapproved protocols.
A request for protocol approval will not extend the timeframe
for submission of the data, nor will extensions generally be
given to conduct studies due to submittal of inappropriate
protocols.
F. Procedures for requesting extensions of time.
If you think that you will need more time to generate
the data than is allowed by EPA1s schedule, you-may submit a
request for an extension of time. Any request for a time
extension which is made as an initial response to a section
3(c)(2)(B) request notice must be submitted in writing to
the Product Manager listed at the end of this section and
must be made before the deadline for response. Once dates
have been committed to and EPA has accepted these commitments,
any subsequent requests for a time extension must be submitted
in writing to the Office of Compliance Monitoring.
EPA will view failure to request an extension before
the response deadline as a waiver of any future claim that
there was insufficient time to submit the data. While EPA
considers your request, you must strive to meet the deadline
for submitting the data.
The extension request should state the reasons why you
believe that an extension is necessary and the steps you
have taken to meet the testing deadline. Time extensions
normally will not be granted due to problems with laboratory
capacity or adequacy of funding, since the Agency believes '
that with proper planning these can be overcome. Time extensions
may be considered when joint data development is planned,
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or when the Agency must approve a new or modified protocol
before the study can be begun.
A request for an extension does not extend the timeframe
for submission of the data. If EPA denies your request for
a time extension and you do not submit the data as requested,
EPA may begin proceedings to suspend the registrations of
your products.
G. Existing stocks provision upon suspension or cancellation.
The Agency has determined that if a registration is
suspended for failure to respond to a DCI request under
FIFRA sec. 3(c)(2)(B), an existing stocks provision is not
consistent with the Act. Accordingly, the Agency does not
anticipate granting permission to sell or distribute existing
stocks of suspended product except in rare circumstances.
If you believe that your product will be suspended or cancelled
and that an existing stocks provision should be granted, you
have the burden of clearly demonstrating to EPA that granting
such permission would be. consistent with the Act. The following
information must be included in any request for an existing
stocks provision:
1. Explanation of why an existing stocks provision is
necessary, including a statement of the quantity of
existing stocks and your estimate of the time required
for their sale or distribution; and
2. Demonstration that such a provision would be consis-
tent with the provisions of FIFRA.
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63
VII. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Under its DCI authority, EPA has determined that certain
product-specific data are required to maintain your registrations
in effect. Product-specific data are derived from testing
using a specific formulated product, and, unlike generic
data, generally support only the registration of that product.
All such data must be submitted by the dates specified in
this Registration Standard.
If you have a manufacturing use product, these data are
listed in Table B. If you have an end use product, the data
are listed in Table C. As noted earlier, the Agency has
decided that it will not routinely require product-specific
data for end use products at this time. Therefore, Table C
may not be contained in this Registration Standard; if there
is no Table C, you are not required to submit the data at
this time.
In order to comply with the product specific data require-
ments, you must follow the same procedures as for generic data.
See Section IV-.D, E, F, and G. You should note, however, that
product chemistry data are required for every product, and the
only acceptable responses are options IV.D.I. (submit data)
or IV.D.6.(cancellation of registration).
Failure to comply with the product-specific data require-
ments for your products will result in suspension of the
product's registration.
-------
64
VIII. REQUIREMENT FOR SUBMISSION OF REVISED LABELING
FIFRA requires each product to be labeled with accurate,
complete and sufficient instructions and precautions, reflecting
the Agency's assessment of the data supporting the product
and its uses. General labeling requirements are set out in
40 CFR 162.10 (see Appendix II - LABELING and SUMMARY). In
addition, labeling requirements specific to products containing
this pesticide are specified in Section IV.D of this Registra-
tion Standard. Applications submitted in response to this
notice must include draft labeling for Agency review.
If you fail to submit revised labeling as required,
which complies with 40 CFR 162.10 and the specific instructions
in Section IV.D., EPA may seek to cancel or suspend the
registration of your product under FIFRA sec. 6.
-------
65
IX. INSTRUCTIONS FOR SUBMISSION
A. Manufacturing Use Products (MUPs) containing azinphos-methyl
as sole active ingredient.
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division
for each product subject to this Registration Standard:
a. The "FIFRA Section 3(c)(2)(B) Summary Sheet" (EPA
Form 8580-1), with appropriate attachments.5
b. Confidential Statement of Formula (EPA Form 8570-4).
c. Formulator's Exemption Statement (EPA Form ),
if applicable.
d. Evidence of compliance with data compensation
requirements of FIFRA sec. 3(c)(l)(D). Refer to 40 CFR
152.80-152.99 .
2. Within 9 months from receipt of thi's document you
must submit to the Product Manager:
a. Application for Pesticide Registration (EPA
Form 8570-1) .
b. Two copies of any required product-specific data
(See Table B).
c. Three copies of draft labeling, including the
container label and any associated supplemental labeling.
Labeling should be either typewritten text on 8-1/2 x 11
inch paper or a mockup of the labeling suitable for
storage in 8-1/2 x 11 files. The draft label must indicate
the intended colors of the final label, clear indication
of the front panel of the label, and the intended type
sizes of the text.
d. Product Specific Data Report (EPA Form 8580-4).
5 if on the Summary Sheet, you commit to develop the data,
present arguments that a data requirement is not applicable
or should be waived, or submit protocols or modified protocols
for Agency review, you must submit a copy of the Summary
Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data
generated in response to this notice. This submission is in
addition to responding to the Product Manager, and should be
submitted to the Office of Compliance Monitoring at the
address given at the end of this section. (Actual studies
are not to be submitted to the Office of Compliance Monitoring.)
-------
66
3. Within the times set forth in Table A, you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator's exemption. If for any
reason any test is delayed or aborted so that the schedule
cannot be met, immediately notify the Product Manager and
the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
B. Manufacturing Use Products containing azinphos-methyl
in combination with other active ingredients.
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division:
a. FIFRA sec. 3(c)(2)(B) Summary Sheet, with appropriate
attachments^ (EPA Form 8580-1).
b. Confidential Statement of Formula (EPA Form 8570-4)
c. Formulator's Exemption Statement, if applicable.
2. Within the time frames set forth in Table A, you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator's exemption. If for any
reason any test is delayed or aborted so that the schedule
cannot be met, immediately notify the Product Manager and
the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
C. End Use Products containing azinphos-methyl as sole
active and multiple active ingredient.
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division:
a. FIFRA Section 3(c)(2-)(B) Summary Sheet, with
appropriate attachments^ (EPA Form 8580-1).
b. Confidential Statement of Formula (EPA Form 8570-4).
c. Formulator's Exemption Statement if applicable.
2. Within 9 months from receipt of this document you
must submit to the Product Manager:
a. Two copies of any product-specific data, if required
by Table C.
b. Product Specific Data Report (EPA Form 8580-4),
if Table C lists required product-specific data.
-------
67
c. Three copies of draft labeling, including the container
label and any associated supplemental labeling. Labeling should
be either typewritten text on 8-1/2 x 11 inch paper or a mockup
of the labeling suitable for storage in 8-1/2 x 11 files. The
draft labeling must indicate the intended colors of the final
label, clear indication of the front panel of the label, and
the intended type sizes of the text. End use product labeling
must comply specifically with the instructions in Section IV
(Regulatory Position and Rationale).
D. Intrastate Products containing azinphos-methyl either
as sole active ingredient or in combination with other
active ingredients.
These products are being called in for full Federal regis-
tration. Producers of these products are being sent a letter
instructing them how to submit an application for registration.
E. Addresses
The required information must be submitted to the following
address:
Lawrence J. Schnaubelt
Registration Division (TS-767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M St., SW
Washington, D.C. 20460
The address for submissions to the Office of Compliance
Monitoring is:
Laboratory Data Integrity Program
Office of Compliance Monitoring (EN-342)
Environmental Protection Agency
401 M St., SW
Washington, D.C. 20460.
-------
68
TGUIDE-1
GUIDE TO TABLES
Tables A, B, and C contain listings of data requirements
for the pesticides covered by this Registration Standard;
Table A contains generic data requirements that apply to
the pesticide in all products, including data requirements
for which a "typical formulation" is the test substance.
Table B contains product-specific data requirements that
apply only to a manufacturing use product.
Table C contains product-specific data requirements that
apply only to an end use product.
The data tables are generally organized according to the
following format:
1. Data Requirement (Column 1). The data requirements are
listed in the order in which they appear in 40 CFR Part 158.
The reference numbers accompanying each test refer to the
test protocols set out in the Pesticide Assessment Guidelines,
which are available from the National Technical Information
Service, 5285 Port Royal Road, Springfield, VA 22161.
2. Test Substance (Column 2). This column lists the composition
of the test substance required to be used for the test, as
follows :
TGAI = Technical grade of the active ingredient
PAI = Pure active ingredient
PAIRA = Pure active ingredient, radio labeled
TEP = Typical end use formulation
MP = Manufacturing use product
EP = End use product
Any other test substances, such as metabolites, will be
"specifically named in Column 2 or in footnotes to the table-.
3. Use pattern (Column 3). This column indicates the use
patterns to which the data requirement applies. Use patterns
are the same as those given in 40 CFR Part 158. The following
letter designations are used for the given use patterns:
A = Terrestrial, food
B = Terrestrial, non-food
C = Aquatic, food
D = Aquatic, non-food
E = Greenhouse, food
F = Greenhouse, non-food
G = Forestry
H = Domestic outdoor
I = Indoor
Any other designations will be defined in a footnote to the table
-------
69
TGUIDE-2
4. Does EPA have data? (Column 4). This column indicates one
of three answers:
YES - EPA has data in its files that completely satisfy
this data requirement. These data may be cited by
other registrants in accordance with data compensation
requirements of Part 152, Subpart E.
PARTIALLY - EPA has some data in its files, but such data
do not fully satisfy the data requirement. In some cases,
the Agency may possess data on one of two required species,
or may possess data on one test substance but not all.
The term may also indicate that the data available to
EPA are incomplete. In this case, when the data are
clarified, or additional details of the testing submitted
by the original data submitter, the data may be determined
to be acceptable. If this is the case, a footnote to
the table will usually say so.
NO - EPA either possesses no data which are sufficient
to fulfill the data requirement, or the data which EPA
does possess are flawed scientifically in a manner that
cannot be remedied by clarification or additional infor-
mation .
5. Bibliographic citation (Column 5). If the Agency has
acceptable data in its files, this column lists the identifying
number of each study. This normally is the Master Record
Identification (MRID) number, but may be a GS number if no
MRID number has been assigned. Refer to the Bibliography
Appendices for a complete citation of the study.
6. Must additional data be submitted? (Column 6). This
column indicates whether the data must be submitted to the
Agency. If column 3 indicates that the Agency already has
data, this column will usually indicate NO. If column 3
indicates that the Agency has only partial data or no data,
£his column will usually indicate YES. In some cases, even
though the Agency does not have the data, EPA will not require
its submission'because of the unique characteristics of the
chemical; because data on another chemical can be used to
fulfill the data requirement; or because the data requirement
has been waived or reserved. Any such unusual situations
will be explained in a footnote to the table.
7. Timeframe for submission (Column 7). If column 5 requires
that data be submitted, this column indicates when the data
are to be submitted, based on the issuance date of the Regis-
tration Standard. The timeframes are those established either
as a result of a previous Data Call-in letter, or standardized
timeframes established by PR Notice 85-5 (August 22, 1985).
8. Footnotes (at the end of each table). Self-explanatory.
-------
70
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement Test Use Does EPA Bibliographic
Substance Patterns Have Data? Citation
V
§158.120 Product Chemistry
Product Identity
61-2 - Description of Beginning TGAI All No
Materials and Manufacturing
Process
61-3 - Discussion of Formation of TGAI All No
Impurities
Analysis and Certification of
Product Ingredients
62-1 - Preliminary Analysis TGAI All No
Physical and Chemical
Characteristics
Must Additional Tiine Frame
Data be for
Submitted? 2/ Submission
Yes 2/ 6 Months
Yes 2/ 6 Months
Yes 2/ 12 Months
63-2 - Color
63-3 - Physical State
63-4 - Odor
63-5 - Melting Point
63-6 - Boiling Point
TGAI
TGAI
TGAI
TGAI
TGAI
All
All
All
Ml
All
No
No
No
No
No
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
6 Months
6 Months
6 Months
6 Months
6 Months
-------
71
TABLE A
GENERIC DATA REQUIREMENTS FDR AZINPHOS-METHYL
Data Requirement
Test Use Does EPA Bibliographic Must Additional Time Frame
Substance Patterns Have Data? Citation Data be for
I/ Submitted? 2/ Submission
§158.120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
63-7
63-8
63-9
63-10
63-11
63-12
63-13
- Density, Bulk Density, or
Specific Gravity
- Solubility
- Vapor Pressure
- Dissociation constant
- Octanol/water partition
coefficient
- pH
- Storage Stability
TGAI All No
TGAI or PAI All No
PAI All No
PAI All No
PAI All NO
TGAI All No
TGAI All No
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
6 Months
6 Months
6 Months
6 Months
6 Months
6 Months
15 Months
I/ Although product chemistry data may have been submitted in the past, the Agency has deteemined that these data must be
resubmitted for each pesticide. New requirements have been introduced and previously submitted data must be updated.
Therefore bibliographic citations for the old data are not applicable.
2/ Generic data are required for the following technical formulations : EPA REG. NO. 3125-108, EPA REG. NO. 11678-4,
EPA REG. NO. 2749-291,and EPA REG. NO. 10163-95.
-------
72
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic
Have Data? Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission
§158.125 Residue Chemistry
171-4 - Nature of Residue
(Metabolism)
- Plants
PAIRA
Partially
00100826
00107018
00112112
GS0235008
00155026
00155065
Yes I/
18 Months
- Livestock
PAIRA and Plant
Metabolites
Partially
171-4 - Residue Analytical Method
- Plant residues
TGAI & Metabolites
Yes
00090275
00090278
00155021
00155019
00155020
00080102
00089642
00089740
00090126
00090127
00090277
00090279
00090946
00093572
00106832
00107018
00107020
Yes 2/
18 Months
No 3/
-------
73
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic
Have Data? Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission
171-4 - Residue Analytical Method
(cont'd)
- Plant residues (cont'd)
- Animal residues
TGAI & Metabolites
Yes
00112052
00112054
00112074
00112083
00112114
00112116
00112120
00112145
00141541
05004211
00155064
00158905
00158906
00112093
00030303
00090274
05004211
GS0235014
GS0235015
No 3/
-------
74
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic Must Additional Timeframe
Have Data? Citation Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Residue Analytical Method
(cont'd)
- Storage Stability Data
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
- Root and Tuber Vegetables
Group 5/
o Crop - Potatoes
— Crop field trials
— Processed Food/Feed
- Bulb vegetable Group 8/
o Crop - Onions
— Crop field trials
PAI
TEP
EP
TEP
Partially
Yes
00030303
00090127
00090275
00112078
00155064
00112039
00112053
Partially 00154989
Partially 00112111
Yes 4/
No 6/
Yes 7/
Yes 9/
15 Months
24 Months
18 Months
-------
75
TABLE A
GENERIC DATA REQUIREMENTS FOR AZ IN PROS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic Must Additional Timeframe
Have Data? Citation Data be . for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
- Leafy Vegetables Group 10/
o Crop - Celery
— Crop field trials TEP
o Crop - Parsley
— Crop field trials TEP
o Crop - Spinach
— Crop field trials TEP
- Brassica Leafy Vegetable
Group 13/
o Crop - Broccoli
— Crop field trials TEP
Partially 00107018
Yes
00112073
Partially 0089740
Partially 00080143
00080144
00107020
00112116
00154989
Yes ll/
No
Yes 12/
Yes 14/
18 Months
18 Months
18 Months
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76
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic Must Additional Timeframe
Have Data? Citation Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Brussels Sprouts
— Crop field trials TEP
o Crop - Cabbage
— Crop field trials TEP
o Crop - Cauliflower
— Crop field trials TEP
- Legume Vegetables Group 18/
o Crop - Beans (Dry and Snap)
— Crop field trials TEP
Partially 00090127
00154989
Partially 00112116
00107020
Partially 00112116
00107020
Partially 00087512
00089740
00090946
00107019
00112052
00154989
Yes 15/
Yes 16/
Yes 17/
Yes 19/
18 Months
18 Months
18 Months
18 Months
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77
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic Must Additional Timefrane
Have Data? Citation Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Peas
— Crop field trials
o Crop - Soybeans
— Crop field trials
— Processed Food/Feed
Fruiting Vegetable Group 23/
o Crop - Eggplants
— Crop field trials
o Crop - Peppers
— Crop field trials
TEP
TEP
EP
TEP
TEP
Partially 00107019
00112035
00112052
Partially 00107020
00112039
00112052
00112086
00112151
No
No
Partially 00107020
Yes 20/
Yes 21/
Yes 22/
Yes 24/
Yes 25/
18 Months
18 Months
24 Months
18 Months
18 Months
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78
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Tomatoes
— Crop field trials
— Processed Food/Feed
Cucurbit Vegetables Group 28/
o Crop - Cucumbers
— Crop field trials
o Crop - Melons
— Crop field trials
Citrus Fruits Group
— Crop field trials
TEP
EP
TEP
TEP
TEP
Partially
No
Partially
00080143
00089740
00112120
00154996
00154989
Partially 00107019
Partially 00107018
00090126
00106832
00112037
00112139
00112143
00112145
Yes 26/
Yes 27/
Yes 29/
Yes 30/
Yes 31/
18 Months
24 Months
18 Months
18 Months
18 Months
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
- Citrus Fruits Group
— Processed Food/Feed
Pcme Fruits Group 33/
o Crop - Apples
— Crop field trials
— Processed Food/Feed
o Crop - Crabapples
— Crop field trials
EP
TEP
EP
TEP
Partially
Partially
Partially
No
00112037
00090126
00112143
00087512
00100824
00112113
00112137
00154989
00154989
00100824
Yes 32/
Yes 34/
Yes 35/
No 36/
24 Months
18 Months
24 Months
-------
80
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic
Have Data? Citation
Must Additional Timeframe
Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Pears
— Crop field trials TEP
o Crop - Quinces TEP
Stone Fruits Crop 37/
o Crop - Apricots
— Crop field trials TEP
o Crop - Cherries
— Crop field trials TEP
o Crop - Nectarines
— Crop field trials TEP
Yes
No
00087512
00100824
00155064
00154989
Partially 00100824
00154989
Partially 00107020
00112145
00154989
Partially 00154989
No 36/
No 36/
Yes 38/
Yes 39/
18 Months
18 Months
Yes 40/
18 Months
-------
81
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic
Have Data? Citation
Must Additional Timeframe
Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Peaches
— Crop field trials
o Crop - Plums
— Crop field trials
TEP
TEP
Partially
Partially
00100824
00154989
00107020
00154989
Yes 41/
Yes 42/
18 Months
18 Months
— Processed Food/Feed
Small Fruits and Berries
Group 44/
o Crop - Blackberries
— Crop field trials
o Crop - Blueberries
— Crop field trials
EP
No
TEP
TEP
Partially
Partially
00089890
00112143
00089740
00107018
00112143
Yes 43/
24 Months
Yes 45/
Yes 46/
18 Months
18 Months
-------
82
• TABLE A
GENERIC TATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does FPA Bibliographic
Have Data? Citation
Must Additional Timefrane
Data be for
Sutmitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Boysenberries
— Crop field trials TEP
o Crop - Cranberries
— Crop field trials TEP
o Crop - Gooseberries 49/
o Crop - Grapes
— Crop field trials TEP
— Processed Food/Feed EP
o Crop - Loganberries
— Crop field trials TEP
Partially 00089890
Partially 00089740
Partially
Partially
Yes
00089642
00112108
00112143
00154989
00089642
00112108
00112143
00154989
00089890
No 47/
Yes 48/
Yes 50/
Yes 51/
18 Months
18 Months
24 Months
No 52/
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83
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-ME1HYL
Data Requirement
Test Substance
Does EPA Bibliographic
Have Data? Citation
Must Additional Timeframe
Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Raspberries
— Crop field trials TEP
o Crop - Strawberries
— Crop field trials TEP
- Tree Nuts Group 54/
o Crop - Almonds
— Crop field trials TEP
o Crop - Filberts
— Crop field trials TEP
o Crop - Pecans
— Crop field trials TEP
Yes 00089890
00112142
Partially 00107020
Partially 00109278
00112159
00158908
Partially 00089740
00112117
Partially 00112126
No 52/
Yes 53/
Yes 55/
Yes 56/
18 Months
18 Months
18 Months
Yes 57/
18 Months
-------
84
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHQ6-METHYL
Data Requirement
Test Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Walnuts
— Crop field trials TEP
- Cereal Grains Group 59/
o Crop - Barley Grain
— Crop field trails TEP
o Crop - Oat Grain
— Crop field trials TEP
o Crop - Rye Grain
— Crop field trials TEP
o Crop - Wheat grain
— Crop field trials TEP
Partially 00112052
Yes
Yes
Yes
00093570
00093572
00093570
00093572
00093572
Partially 00080143
00080144
00093570
00093572
00154989
Yes 58/
No 60/
No 60/
No 60/
Yes 61/
18 Months
18 Months
— Processed Food/Feed
EP
No
Yes 62/
24 Months
-------
85
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Must AdditionalTimeframe^/
Data be for
Submitted? Submission
Data Requirement
Test Substance1/
Does EPA
Have Data?
Bibliograph ic
Citation
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
- Forage, Fodder, and Straw of
Cereal Grains Group 63/
o Crop - Barley, Forage, Hay
and Straw
— Crop field trials
TEP
Yes
00093570
00093572
No 64/
o Crop - Oat, Forage, Hay,
and Straw
— Crop field trials
o Crop - Rye Straw
— Crop field trials
o Crop - Wheat Forage, Hay,
and Straw
— Crop field trials
TEP
Yes
TEP
Yes
TEP
00093570
00093572
00093572
Partially 00080143
00080144
00093570
00093572
00154989
No 64/
No 64/
Yes 65/
18 Months
-------
86
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPH06-METHYL
Data Requirement
Test Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude ,of the Residue-
Residue Studies for Each
Food Use
- Grass Forage, Fodder, and
Hay 66/
o Crop - Grass Forage, arid Hay
— Crop field trials
Non-Grass Animal Feeds
Group 68/
o Crop - Alfalfa Forage and Hay
— Crop field trials
TEP
Partially
TEP
Partially
o Crop - Birdsfoot Trefoil
Forage and Hay
00070492
00112035
00117750
00035890
00067494
00090273
00090276
00090280
00154989
Yes 67/
18 Months
Yes 69/
18 Months
— Crop field trials
TEP
No
No 70/
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87
TABLE A
GENERIC DATA REQUIREMENTS FOP AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Clover Forage and
Hay
*
— Crop field trials TEP
Miscellaneous Ccmnodities
o Crop - Artichokes
— Crop field trials TEP
o Crop - Cottonseed
— Crop field trials TEP
Partially 00090273
00090280
Partially 00089740
Partially
00029078
00045038
00080143
00080144
00087511
00098957
00102272
00102299
00112027
00112039
00112054
00112071
00112110
00112112
Yes 71/
Yes 72/
Yes 73/
18 Months
18 Months
18 Months
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TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Cottonseed (cont'd)
— Crop field trials
— Processed Food/Feed
o Crop - Kiwi
— Crop field trials
o Crop - Pistachio
— Crop field trials
o Crop - Sugarcane
— Crop field trials
EP
TEP
00112114
00141541
00154989
Partially 00102272
00112039
00112054
00112112
00112071
Partially 00112072
00158909
TEP
TEP
Yes
Partially
00112074
00091562
00112024
00112026
00112083
00112115
Yes 74/
Yes 75/
No
Yes 76/
24 Months
18 Months
18 Months
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89
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Substance
Does EPA Bibliographic
Have Data? Citation
Must Additional
Data be
Submitted?
Ti/neframe
for
Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
o Crop - Tobacco
— Crop field trials
- Magnitude of the Residue in
Meat, Milk, Poultry, and
Eggs
o Cattle, Goats, Sheep, and
Horses
o Milk
TEP
No
TEP
Yes
Yes
00030303
00090126
00030303
00090126
Yes 77/
No 78/
No 78/
18 Months
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90
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes
I/ The metabolism of azinphos-methyl in plants is not adequately understood. Data reflecting the distribution and
metabolism of either benzene or triazine-labeled [l^c]azinphos-methyl in mature fruit of an orchard crop, mature
cottonseed, and mature potato tubers following foliar treatment are required. Application rates must be sufficiently
high to permit complete J-^C-residue identification.
2/ Metabolism studies utilizing ruminants and poultry are required. Animals must be dosed tor three days with ring-
labeled [14cjazinphos-methyl at a level sufficient to make residue identification and quantification possible. Milk
and eggs must be collected twice daily during the dosing period. Animals must be sacrificed within 24 hours of the
final dose. The distribution and characterization of residues must be determined in milk, eggs, liver, kidney,
muscle, and fat.
3/ If additional metabolites of concern are found in plants or animals (as required in 171-4, Nature of Residue in •
Plants and Animals) data may be required.
4/ The storage intervals and conditions of storage for all samples used to support established tolerances and used for
additional residue data required under this standard must be submitted. These must be accompanied by data depicting
the percent decline in residues under those intervals and conditions unless plant and animal commodities are stored
frozen for up to 72 weeks or 4 weeks, respectively.
5/ A crop group tolerance is not appropriate at the present time because addition residue data are required for three
additional members of this crop group (carrot, radish, and sugar beet); currently, potato is the only crop in this
crop group on which a registered use of azinphos-methyl exists.
6/ A revised label must be submitted limiting the number of applications per growing season or establishing a minimum
interval between applications.
7/ Residue data must be submitted for granules, chips, and dried potatoes processed from potatoes. It may be necessary
to use exaggerated rates to obtain measurable residues in the raw agricultural commodmity. If residues concentrate
in any of the processed products, appropriate food/feed additive tolerances must be processed.
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91
TABLE A
GENERIC E&TA REQUIREMENTS FOR AZINPHOS-METHYL
158.125 Residue Chemistry - Footnotes (cont'd)
8/ A crop group tolerance is not appropriate because additional data are required to support the established tolerances
for residues in or on green and dry bulb onions. Also, residue data are required for one additional group member
(garlic); currently, onions is the only crop in this crop group on which registered uses of azinphos-methyl exist.
9/ The submitted data are not adequate to support the established tolerance for azinphos-methyl in or on onions (green
or dry bulb). Data depicting azinphos-methyl residues in or on green onions harvested at intervals following the last
three applications of 50% WP and 2 Ib/gal EC formulatons, in separate tests, at 0.75 Ib ai/A/application must be
submitted. A minimum interval between applications must be proposed. Tests with green onions should be conducted
in CA, TX, and AZ. Also data depicting azinphos-methyl residues in or on dry bulb onions harvested at intervals
following the last three applications of 3%D, one of the WP, and 2 Ib/gal EC formulations at 0.75 Ib ai/A/
application, and 5% EC formulation at 2 tbls/gal (maximum gallons per acre must be specified). Tests with dry bulb
onions should be conducted in CA, TX, NY, OR, and CO.
10/ A crop group tolerance is not appropriate at the present time because additional data are required to support the
established tolerances for azinphos-methyl residues in or on celery and spinach. Residue data are also required
for an additional representative crop (lettuce). Currently, celery, parsley, and spinach are the only crops in this
crop group on which registered uses of azinphos^nethyl exist.
ll/ The available data are not adequate to support the established tolerance for residues of azinphos-methyl in or on
celery. Residue data in or on untriircned celery harvested 7 days after the last of multiple foliar applications with
a WP formulation are required. The studies should take place in CA. The maximum number of applications per season,
or a-maximum seasonal rate should be submitted with appropriate data.
12/ The submitted data are not sufficient to support the established tolerance in or on spinach. Data depicting
Azinphosthyl residues of concern in or on spinach harvested 14 days after the last of multiple foliar applications
with a WP and an EC formulation (in separate tests) at 0.5 Ib ai/A and, a D formulation at 0.75 Ib ai/A are required.
Tests must be conducted in TX, CA, NJ, OK, NY, AND AR. A maximum number of applications per season or a maximum
seasonal rate must be submitted with appropriate data. The submitted data must reflect this proposed maximum.
13/ A crop group tolerance is not appropriate at the present time because additional residue data are required to support
the established tolerances for residues of azinphos-methyl in or on broccoli and cabbage. Also, a use and a tolerance
must be proposed and reporting residue data submitted for one additional representative ccnmodity (mustard greens).
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92
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
14/ The'available data are not sufficient to assess the established tolerance for residues of azinphos-methyl in or on
broccoli. Data depicting azinphos-methyl residues of concern in or on broccoli harvested 14 days after the last of
multiple foliar applications, and 21 days after the last of several transplant applications are required. Foliar
applications must be made utilizing a D and an EC formulation (in separate tests) at 0.75 Ib ai/A. Application must
be made with ground and aerial equipment. Transplant applications must be made utilizing an EC, FlC, or WP
formulation at 0.75 Ib ai/A. Tests must be conducted in CA and TX. A maximum permissible number of applications
per season for both transplant water and foliar applications must be proposed with the appropriate data. Tests in CA
must be conducted using the same above-mentioned tests in addition to direct soil application of the 25% or 50% WP,
2 Ib/gal EC, or 2 or 3 Ib/gal FlC as a broadcast application at 0.75 Ib ai/A.
15/ The available data are insufficient to assess the established tolerance for residues of azinphos-methyl in or on
brussels sprouts. Data depicting azinphos-methyl residues of concern in or on brussels sprouts harvested 14 days
after the last of multiple foliar applications, and 21 days after the last of several transplant applications are
required. Foliar applications must be made utilizing a D and an EC formulation (in separate tests) at 0.75 Ib ai/A.
Applications must be made with ground and aerial equipment. Transplant applications must be made utilizing an EC,
FlC, or WP formulation at 0.75 Ib ai/A. These tests must be conducted in CA using the same above-mentioned tests
in addition to direct soil application of the 25% or 50% WP, 2 Ib/gal EC, or 2 or 3 Ib/gal FlC as a broadcast
application at 0.75 Ib ai/A. A maximum number of applications per season for transplant water and foliar applica-
tions must be submitted with appropriate data.
16/ The available data are not sufficient to assess the established tolerance for residues of azinphos-methyl in or on
cabbage. Data depicting azinphos-methyl residues of concern in or on cabbage harvested 14 days after the last of
multiple foliar applications, and 21 days after the last of several transplant applications must be submitted.
Foliar applications must be made utilizing a D and an EC formulation (in separate tests) at 0.75 Ib ai/A. Applica-
tion must be made with ground and aerial equipment. Transplant applications must be made utilizing an EC, FIC, or
WP formulation at 0.75 Ib/ai/A. These tests must be conducted in CA, FL, NY, TX, and WI. Tests in California must
be conducted using the .same above-mentioned tests in addition to direct soil application of the 25% or 50% WP, 2
Ib/gal EC or 2 or 3 Ib/gal FlC formulation as a broadcast application at 0.75 Ib ai/A. The label must be revised to
express the rate in terms of Ibs ai/A or, if a solution, the number of gallons per acre. A maximum number of appli-
cations per season for both transplant water and foliar applications must be submitted with supporting data.
17/ The available data are not sufficient to assess the established tolerance for residues of azinphos-methyl in or on
cauliflower. Data depicting azinphos-methyl residues of concern in or on cauliflower harvested 14 days after the last
of multiple foliar applications, and 21 days after the last of several transplant applications, must be submitted.
Foliar applications must be made utilizing a D and an EC formulation (in separate tests) at 0.75 Ib ai/A. Application
must be made with ground and aerial equipment and transplant applications must be made utilizing an EC, FlC, or WP at
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93
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
0.75 Ib ai/A. These tests must be conducted in CA and NY. Tests in California must be conducted using the same
above-mentioned tests in addition to direct soil application of the 25% or 50% WP, 2 Ib/gal EC or 2 or 3 Ib/gal F1C
as a broadcast application at 0.75 Ib ai/A. A maximum number of applications per season for transplant water and
foliar applications must be submitted with appropriate supporting data. The label must be revised to express the
rate in terms of Ib ai/A, or, if a solution, the number of gallons per acre.
18/ A crop group tolerance is not appropriate at the present time because additional data are required to support the
established tolerances for azinphos-methyl residues in or on beans (dry and snap), field peas, and soybeans.
19/ The available data are insufficient to support the established tolerances for residues of azinphos-methyl in or on
dry or snap beans. Data depicting azinphos-methyl residues of concern in or on dry and snap beans following four
foliar applications (in separate studies) of: (i) a WP formulation at 0.5 Ib ai/A; (ii) an EC formulation at
0.5 Ib ai/A; and (iii) a D formualtion at 0.6 Ib ai/A are required. Aerial and ground applications must be
represented. The first application should be made prior to the normal time of disease development and three addi-
tional applications should be made at regular intervals until 7 days prior to harvest (for snap beans) or 30 days
prior to harvest (for dry beans). Tests with snap beans should be conducted in WI, NY, OR, and FL. Tests with dry
beans should be conducted in the States of MI, CA, NE, CO, ND, and ID.
20/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
field peas. Data depicting azinphos-methyl residues of concern in or on field peas following four foliar applications
(in separate tests) of WP and D formulations at 1 Ib ai/A ar required. Aerial and ground applications must be
represented. The first application should be made prior to the normal time of disease development and three addi-
tional applications should be made at regular intervals until 7 days prior to harvest. Tests should be conducted in
WA and ID.
21/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
soybeans. Data depicting azinphos^nethyl residues of concern in or on soybeans following multiple foliar applications
(at regular intervals) of the D, EC, and WP formulations at 0.9 and 0.75 Ib ai/A, respectively (in separate tests)
are required. Aerial and ground applications must be represented. You must propose a maximum permissible number of
applications per season or maximum Ib ai/A/season rate. Required tests must reflect the maximum seasonal rate pro-
posed. Tests should be conducted in IL, IA, IN, MS, MN, and OH.
22/ Data depicting residues in soybean meal, hulls, soapstock, crude oil, and refine oil from soybeans bearing measurable
weathered residues are required. If residues concentrate in any of these processed commodities, appropriate food/feed
additive tolerances must be proposed.
-------
93
~u- 1- !•", ' A
GENERIC LATA REQU1R;:- T3 FOR AZINPHOS-METHYL
" Footnotes (cont'd)
0,75 Ib ai/A. These tests must oe conducted in CA and NY. Tests in California must be conducted using the same
above-mentioned tests in addition to direct soil application of the 25% or 50% WP, 2 Ib/gal EC or 2 or 3 Ib/gal F1C
as a broadcast application at 0.75 Ib ai/A. A maximum number of applications per season for transplant water and
foliar applications must be submitted with appropriate supporting data. The label must be revised to express the
rate in terms of Ib ai/A, or, if a solution, the number of gallons per acre.
18/ A crop group tolerance is not appropriate at the present time because additional data are required to support the
established tolerances for azinphos-methyl residues in or on beans (dry and snap), field peas, and soybeans.
19/ The available data are insufficient to support the established tolerances for residues of azinphos-methyl in or on
dry or snap beans. Data depicting azinphos-methyl residues of concern in or on dry and snap beans following four
foliar applications (in separate studies) of: (i) a WP formulation at 0.5 Ib ai/A; (ii) an EC formulation at
0.5 Ib ai/A; and (iii) a D formualtion at 0.6 Ib ai/A are required. Aerial and ground applications must be
represented. The first application should be made prior to the normal time of disease development and three addi-
tional applications should be made at regular intervals until 7 days prior to harvest (for snap beans) or 30 days
prior to harvest (for dry beans). Tests with snap beans should be conducted in WI, NY, OR, and FL. Tests with dry
beans should be conducted in the States of MI, CA, NE, CO, ND, and ID.
20/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
field peas. Data depicting azinphos-methyl residues of concern in or on field peas following four foliar applications
(in separate tests) of WP and D formulations at 1 Ib ai/A ar required. Aerial and ground applications must be
represented. The first application should be-made prior to the normal time of disease development and three addi-
tional applications should be made at regular intervals until 7 days prior to harvest. Tests should be conducted in
WA and ID.
21/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
soybeans. Data depicting azinphos-methyl residues of concern in or on soybeans following multiple foliar applications
(at regular intervals) of the D, EC, and WP formulations at 0.9 and 0.75 Ib ai/A, respectively (in separate tests)
are required. Aerial and ground applications must be represented. You must propose a maximum permissible number of
applications per season or maximum Ib ai/A/ season rate. Required tests must reflect the maximum seasonal rate pro-
posed. Tests should be conducted in IL, IA, IN, MS, MN, and OH.
22/ Data depicting residues in soybean meal, hulls, soapstock, crude oil, and refine oil from soybeans bearing measurable
weathered residues are required. If residues concentrate in any of these processed commodities, appropriate food/feed
additive tolerances must be proposed.
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94
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPH06-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
23/ A crop group tolerance is not appropriate because additional data are required to support the existing tolerances
tor azinphos-methyl residues in or on pepper and tomatoes.
24/ No data were submitted for eggplants. Based on data translated from tomatoes and peppers a more appropriate
tolerance level would appear to be 0.5 ppm provided a maximum of 3 applications and a 21-day PHI are imposed. If
the PHI and number of applications are not acceptable, additional residue data from FL and NJ reflecting the
maximum proposed use will be required.
25/ The data are inadequate to assess the established tolerance for residues of azinphos-methyl in or on peppers. Data
depicting'azinphos-methyl residues in or on peppers harvested 14 days after the last of a minimum of four foliar
applications of the 2 Ib gal EC and, in a separate test, a WP formulation at 0.5 Ib ai/A are required. The use of
ground and aerial equipment must be represented. A maximum number of applications per season or maximum Ib ai/A per
season rate must be submitted and the requested data must reflect the maximum rate proposed. Tests should be
conducted in FL, CA, and TX.
26/ The data are insufficient to support the established tolerance in or on tomatoes. Data depicting azinphos-methyl
residues of concern in or on tomatoes following multiple foliar applications by aircraft of, in separate tests, a
D formulation at 0.75 Ib ai/A, a WP formulation at 1.5 Ib ai/A and the 2 Ib/gal EC formulation at 1.5 Ib in 1 ai/A are
required. The first application should be made at the normal time of disease development and be repeated at regular
intervals until 14-days prior to harvest. A maximum number of applications per season or a maximum Ib ai/A per
season rate must be submitted. Requested data must reflect the proposed maximum rate. Tests should be conducted in
FL and CA.
27/ Data depicting azinphos-methyl residues in wet and dry pomace, puree, catsup, and juice processed from tomatoes
bearing measurable weathered residues are required. It may be necessary to use exaggerated rates to obtain measurable
residues in the raw agricultural commodity. If residues concentrate in any of these processed products, appropriate
food/feed additive tolerances must be proposed.
28/ A crop group tolerance is not appropriate because additional data are required to support the established tolerances
for azinphos-methyl residues in or on cucumbers and melons and a tolerance and use directions must be submitted along
with appropriate residue data for one additional group member (summer squash); currently, cucumbers and melons are the
only two crops in this crop group on which registered uses of azinphos-methyl exist.
29/ The data are inadequate to assess the established tolerance for residues of azinphos-methyl in or on cucumbers. Data
reflecting the residues in or on cucumbers resulting from three foliar applications of a WP and an EC formulation in
separate tests at 0.5 Ib ai/A are required. Cucumbers must be harvested 3 days after the final application. Tests
must be conducted in MI, NC, FL, and TX.
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95
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
30/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
melons. Data reflecting residues of concern in or on melons resulting fron four applications (at 5- to 7-day
intervals) of an EC formulation at 0.5 Ib ai/A per application are required. Melons must be harvested immediately
following the last foliar application. Tests with cantaloupes must be conducted in CA and TX. Tests with watermelons
must be conducted in TX, FL, CA, GA, and SC. Tests with honeydew melons must be conducted in CA and TX.
31/ The submitted data are not adequate to support the established tolerance for the residues of azinphos-methyl in or on
citrus fruit. The following data are required: Data depicting the residues of concern in or on oranges, grapefruit,
and lemons harvested at regular intervals (until maturity) after two foliar applications of an EC and, in separate
tests, of a WP formulation at 7.5 Ib ai/A and 0.375 Ib ai/100 gal of spray, respectively. Applications must be by
aerial, and in separate tests, by ground equipment. A minimum interval between applications is required and the
required studies must reflect this interval. Residue data must permit evaluation of the established PHI. Tests on
oranges and grapefruit must be conducted in CA and FL and lemon tests must be conducted in CA and FL and lemon tests
must be conducted in CA. A higher tolerance level proposal or a longer PHI may be acceptable.
32/ Data depicting residues of concern in citrus molasses and juice (and additional data for citrus oil) processed fron
fruit bearing measurable, weathered reisudes are required. Should residues concentrate in any processed commodity,
appropriate food/feed additive tolerances must be proposed.
33/ A crop group tolerance is not appropriate because additional residue data are required to support the existing
established tolerances for residues in or on apples and pears.
34/ The data are insufficient to support the established tolerance for residues of azinphos-methyl in or on apples. Data
depicting azinphos-methyl residues of concern in or on apples harvested: (i) 15-days after the last of eight appli-
cations (including aerial and ground equipment in separate tests) at seven-day intervals of a D formulation at 2.1 Ib
ai/A; and (ii) seven days after the last of eight applications at seven-day intervals of a D formulation, with the
first six applications made at 2.1 Ib ai/A and the last two applications made at 2 Ib ai/A are required.
An adjustment in use directions to establish a single PHI for all registered uses of the dust formulations may be
proposed and the data requirements will then be altered to coincide with such an adjustment. Residue data are
required for both EC and WP formulations: (i) 15 days after the last of eight foliar applications (at 10-day inter-
vals) at 3.13 Ib ai/A in 1,000 gal of spray suspension/A (including aerial and ground applications in separate tests);
and (ii) 7-days after the last of eight ground applications; the first six made at 2.5 Ib ai/A and the last two at
2 Ib ai/A. Residue dta are required for a WP formulation seven days after the last of three foliar applications (at
7-day intervals) with aerial equipment at 1.5 Ib ai/A. These tests should be conducted in WA, NY, and MI. Residue
data are also required for an EC formulation 7 days after the last of five foliar applications (at 7-day intervals)
with ULV aerial equipment at 1 Ib ai/A. These tests should be conducted in ID, OR, WA, or UT since this use is
limited to these States.
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96
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
35/ Depiction of residues in wet pomace, dry pomace, and juice, processed from apples bearing measurable, weathered
residues is required. Appropriate food/feed additive tolerances must be proposed should concentration of residues
occur in processed products.
36/ Although data are inadequate to evaluate the established tolerances, no data are required because the required apple
data will be translated to crabapples, pears, and quince to evaluate their established tolerances.
37/ A crop group tolerance is not appropriate because additional data are required to support existing tolerances for
residues in or on cherries, peaches, and plums and fresh prunes (refer to individual crop sections for details).
38/ The available data do not support the established tolerance for residues of azinphos-methyl in or on apricots. Data
depicting the azinphos-methyl residues of concern in or on apricots harvested 21 days after the last foliar treatment
of the following full-season treatment schedules: .(i) three bark applications of an EC formulation and, in a separate
test, a WP formulation at 0.375 Ib ai/100 gal, applied at 800 gal/A; (ii) eight foliar applications of an EC formu-
lation and, in a separate test, a WP formulation at 0.375 Ib ai/100 gal, applied at 800 gal/A by ground equipment;
(iii) eight foliar applications of a D formulation at 2.4 Ib ai/A (aerial and ground equipment must be represented in
separate tests); and (iv) multiple foliar applications of a 50 percent packeted WP at 2.5 Ib ai/A applied in at least
5 gal water/A by aerial equipment are required. A label restriction giving the maximum number of applications allowed
per season is also required, and the required studies must reflect that number. These studies must be conducted in
CA.
39/ The available data are inadequate to support the established tolerance for residues of azinphos-methyl in or on
cherries. The following data are required:
a. Data depicting azinphos-methyl residues of concern in or on cherries harvested 15 days after the last of eight
foliar applications by ground and, in separate tests, by aerial equipment, of a WP and, in a separate study, an EC
formulation, each at 0.5 Ib ai/100 gal. You must propose a maximum gal/A/application rate and the required data
must reflect the proposed maximum rate.
b. Data depicting azinphos-methyl residues of concern in or on cherries harvested 15 days after the last of eight
foliar applications of a D formulation by ground and, in a separate test, aerial equipment at 2.4 Ib ai/A. Tests
should be conducted in WA, OR, and MI.
40/ The available data are inadequate to support the existing tolerance for residues of azinphos-methyl in or on
nectarines. Data depicting the azinphos-methyl residues of concern in or on nectarines harvested 21 days after the
last foliar treatment of the following full-season treatment schedules: (i) three bark applications of an EC and, in
-------
TABLE A
GENERIC EATA REQUIREMENTS FOR AZINPHOS-MEIHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
a separate test, a WP formulation at 0.375 Ib ai/100 gal, applied at 800 gal/A; (ii) eight foliar applications of an
EC and, in a separate test, of a WP formulation at 0.375 Ib ai/100 gal, applied at 800 gal/A by ground equipment;
(iii) eight foliar applications of a D formulation at 2.4 Ib ai/A (by ground and, in a separate test, by aerial
equipment) must be submitted. These studies must be conducted in CA.
41/ The available data are inadequate to support the established tolerance for residues of azinphos-methyl in or on
peaches. Data depicting the azinphos-methyl residues of concern in or on peaches harvested at 21 days after the last
foliar treatment of the following full-season treatment schedules: (i) three bark applications of an EC and, in a
separate test, of a WP formulation at 0.375 Ib ai/100 gal, applied at 800 gal/A, by ground equipment; (ii) eight
foliar applications of an EC and, in a separate test, a WP formulation at 0.375 Ib ai/100 gal applied at
800 gal/A by ground equipment; (iii) eight foliar applications of a D formulation at 2.4 Ib ai/A (by ground and, in
a separate test, by aerial equipment); and (iv) multiple foliar applications of a 50 percent packeted WP formulation
at 2.5 Ib ai/A in at least 5 gal water/A by aerial equipment must be submitted. A label restriction giving the
maximum number of applications allowed per season are required and the required studies must reflect that number.
All tests utilizing the packeted WP must be conducted in CA; all other tests must be conducted in the States of CA
and GA.
42/ The available data do not provide adequate support for the established tolerance for residues of azinphos-methyl in
or on plums and fresh prunes. The following data are required: Data depicting azinphos-methyl residues of concern
in or on plums and fresh prunes resulting from the following full-season application schedules: (i) Three bark appli-
cations with a WP formulation and, in a separate test, with an EC formulation at 0.5 Ib ai/100 gal. (ii) Eight foliar
applications (at regular intervals) with a WP, and EC, and a D formulation (each in separate tests) at 0.5 Ib ai/100
gal, 0.5 Ib ai/100 gal, and 2.4 Ib ai/A, respectively. Aerial and ground uses must be represented. A label restric-
tion listing the maximum use rate (Ib ai/A) per application for the WP and EC formulations must be proposed. The
required data must reflect this proposed maximum rate. Tests must be conducted in MI, OR, and WA. (iii) Multiple
foliar applications, using aerial equipment, of a WP formulation (in water-soluble packets) at 2.5 Ib ai/A, applied
in at least 5 gal water per acre. These studies must reflect a 21-day PHI, and must be conducted in CA. You must
propose a label restriction listing the maximum number of applications allowed per season and the required data must
reflect that number). Similar residue data are required for eight foliar applications of this formulation, using
ground equipment, at 4 Ib ai/800 gal water/A. These tests must be conducted in CA, and must reflect a 15-day PHI.
43/ Residues must be determined in dried prunes processed from plums bearing measurable weathered residues. If residues
concentrate in this processed product, an appropriate food additive tolerance must be proposed.
44/ A crop group tolerance is inappropriate because additional data are required to support the established tolerances for
residues of azinphos-methyl in or on the representative commodities blackberries, blueberries, cranberries, grapes and
strawberries.
-------
98
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
45/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or
on blackberries. Data depicting azinphos-inethyl residues of concern in or on blackberries 14 days after the last of
two foliar applications of: (i) an EC formulation applied aerially at 0.51 Ib/A; (ii) a WP formulation applied
aerially at 0.51 Ib ai/A; (iii) a D applied with ground equipment at 0.9 Ib ai/A; and ( iv) a D applied aerially at
0.9 Ib ai/A are required. Data are also required depicting residues of concern in or on blackberries 3 days after
the last of two soil applications of, in separate tests, EC and WP formulations at 2 Ib ai/A. A minimum interval
between applications must be proposed and tests should be conducted in OR and CA.
46/ The available data are not adequate to support the established tolerance. The following data are required:
a. Depiction of azinphos-methyl residues of concern in or on blueberries following aerial applications of a D
formulation as follows: (i) from samples harvested four hours after the last of two applications at 0.6 Ib ai/A;
(ii) from samples harvested 9 hours after the last of five applications at 0.6 Ib ai/A; and (iii) from samples
harvested 14 days after the last two applications at 0.9 Ib ai/A.
b. Depiction of the same residues following ground applications of a D formulation as follows: (i) from samples
harvested 7 days after the last of two application at 0.6 Ib ai/A; and (ii) frcm samples harvested 14 days after
the last of two applications at 0.9 Ib ai/A. For all tests, applications made more than 14 days prior to harvest
must be at 0.9 Ib ai/A.
c. Depiction of the same residues following ground and aerial applications of an EC and a WP formulation (all in
separate tests) as follows: (i) from samples harvested 3 days after the last of four applications at 0.75 Ib
ai/A; and (ii) 14 days after the last of two applications made at 1.0 Ib ai/A. For all tests, applications made
more than 14 days prior to harvest must be at 1 Ib ai/A. Tests should be conducted in MI and NJ. A minimum
interval between applications must be submitted.
47/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
boysenberries. No additional data, however, are required because data for blackberries will be translated to
boysenberries.
48/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
cranberries. Data depicting azinphos-methyl residues of concern in or on cranberries following multiple foliar
applications of, in separate tests, a D formulation at 0.92 Ib ai/A, a WP formulation at 1 Ib ai/A, and an EC
formulaton at 1 Ib ai/A are required. Applications must ccmmence prior to the normal time of disease development and
be repeated at 7-day intervals until 21 days prior to harvest. Aerial and ground application must be represented. A
maximum number of applications per season or maximum Ib ai/A per season must be proposed and the required data should
reflect the proposed maximum rate. Tests should be conducted in WI and MA.
-------
TABLE A
GENERIC EATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
49/ There are not registered uses for azinphos-methyl on gooseberries. You must propose use directions and provide
supporting residue data that reflect the maximum proposed rate or you may elect to cancel the tolerance.
50/ The available data indicate that the registered use's will likely result in residues exceeding the presently
established tolerance for grapes. The available data are insufficient to propose a new tolerance level for residues
of azinphos-methyl in or on grapes. Data depicting azinphos-methyl residues of concern in or on grapes following
three foliar applications of a D formulation as follows: (i) immediately after the last application at 0.7 Ib ai/A;
and (ii) 10 days after the last application at 0.9 Ib ai/A are required. Applications made more than 10 days before
harvest applications must be made at the maximum permitted rate of 0.9 Ib ai/A. Data are also required depicting
similar residues from application of EC and WP formulations in separate tests, as follows:
(i) immediately after the last application at 0.75 Ib ai/A;
(ii) 10 days after the last application at 1.13 Ib ai/A; and
(iii) 28 days after the last application at 1.5 Ib ai/A.
Applications made more than 28 days before harvest must be made at the maximum permitted rate of 1.5 Ib ai/A. Aerial
and ground use must be represented. Tests should be conducted in CA and NY.
51/ Data depicting residues in wet and dry pomace, raisins and raisin waste processed from grapes bearing measurable,
weathered residues are required. If residues concentrate in any of these processed commodities, appropriate food/feed
additive tolerances must be proposed.
52/ The available data are insufficient to support the established tolerances for residues of azinphos-methyl in or on
loganberries and raspberries. No additional data are required, however, because required data for blackberries will
be translated to loganberries and raspberries.
53/ The available data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
strawberries. Data depicting azinphos-methyl residues of concern in or on strawberries following multiple foliar
applications (at regular intervals) of a D formulation and in separate tests, a WP and EC formulation at 0.5 Ib ai/A
are required. The first application should be made at the normal time of disease development and applications must
be repeated at regular intervals until 5 days prior to harvest. Aerial and ground use must be represented. You
must propose a maximum number of applications per season or maximum seasonal rate per acre and the required data
must reflect the proposed maximum rate. Tests should be conducted in CA and FL.
54/ A crop group tolerance is not appropriate because additional data are required to support the established tolerances
for residues in or on almonds, pecans, and walnuts.
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100
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
55/ The available data do not support the established tolerance for azinphos-methyl residues in or on almonds and almond
hulls. Data depicting azinphos^nethyl residues of concern in and on almonds (nutmeats and hulls) harvested after two
foliar applications of the EC formulation at 2.5 Ib ai/A (applied in 500 gal/A) using ground and aerial equipment are
required. Applications must be 30 days apart. These studies must reflect a 60-day PHI, and must be conducted in CA.
56/ The available data do not support the established tolerance for residues of azinphos-methyl in or on filberts. Data
frcm studies depicting azinphos-methyl residues of concern in and on filberts harvested after multiple foliar applica-
tions of an EC and, in separate tests, a WP formulation at 7.5 Ib ai/A (0.75 Ib ai/100 gal water, applied at 1,000
gal/A) are required. Tests must reflect the use of ground and aerial equipment, 'must reflect a 30-day PHI, and must b
conducted in OR and WA. You must propose a label restriction that gives the maximum number of applications allowed
per season and the data required above must reflect that number.
57/ The available data do not support the established tolerance for residues of azinphos-methyl in or on pecans. Data
depicting azinphos-methyl residues in and on pecans harvested on the day of the last of a series of multiple foliar
applications (ending prior to husk split) of a WP formulation and, in separate tests, of an EC formulation, applied at
10.08 Ib ai/A (0.56 Ib ai/100 gal, at 1800 gal/A) are required. Separate tests should reflect ground and aerial
application of each formulation. In lieu of conducting tests reflecting a 0-day posttreatment interval, an alternate
PHI may be proposed and submitted with residue data. The studies must be conducted in GA, MM, LA, AL, and TX. You
must propose a label restriction that gives the maximum number of applications allowed per season and the data
required above must reflect that number.
58/ The available data do not support the established tolerance for residues of azinphos-methyl in or on walnuts. Data
depicting residues of azinphos-methyl residues of concern in and on walnuts harvested on the day of the last of a
series of foliar applications (ending prior to husk split) of a WP formulation, and in separate tests, an EC formula-
tion, applied at 10.34 Ib ai/A by ground and, in separate tests, by aerial equipment are required. Separate studies
must reflect application of a D formulation by ground and, in separate tests, by air, at 1.5 Ib ai/A. These studies
must be conducted in CA. A label restriction that gives the maximum number of applications allowed per season must be
submitted and the data required above must reflect that number.
59/ A crop group tolerance is inappropriate because additional residue data are required to support the existing tolerance
for azinphos-methyl residues in or on wheat and tolerances must be established and appropriate supporting data
provided for additional representative ccmmodities (corn [fresh sweet and dried filed], rice, and sorghum).
60/ The data are insufficient to assess the established tolerances for residues of azinphos-methyl in or on oat, rye, and
barley grain. No additional data are required because the required data for wheat will be translated to oat, rye, and
barley grain.
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101
TABLE A
GENERIC EATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
61/ The data are insufficient to assess the established tolerance for residues of azinphos-methyl in or on wheat grain.
Data depicting azinphos^nethyl residues of concern in or on wheat grain harvested 30 days following a single foliar
application of an EC formulation and, in a separate test, a WP or a F1C formulation at 0.5 Ib ai/A with a 30-day pre-
harvest interval are required. Tests must reflect both ground and aerial applications. Tests should be conducted in
KS, ND, WA, TX, OK, and MT.
62/ Data depicting azinphos-methyl residues in milled products processed from wheat bearing measurable weathered residues
are required. If residues concentrate in milled products, an appropriate food/feed additive tolerance must be
proposed.
63/ A crop group tolerance is inappropriate at the present time because additional residue data are required to support
the established tolerances for wheat straw and one other cereal forage crop (barley forage, hay and straw; oat forage,
hay and straw; rye straw; or sorghum forage, fodder, hay and silage). A tolerance poposal must be submitted for
corn forage, fodder, and silage.
64/ The data are insufficient to assess the established tolerances for residues of azinphos-methyl in or on barley, oat,
or rye straw however, no additional data are required, since the required data for wheat straw will be translated to
barley, oat, and rye straw.
65/ The data are insufficient to assess the established tolerance for residues of azinphos-methyl in or on wheat straw.
Data depicting azinphos-methyl residues of concern in or on wheat straw harvested 30 days following a single foliar
application of an EC formulation and, in a separate test, a WP formulation at 0.5 Ib ai/A are required. Applications
must be made using both ground and aerial equipment. Tests should be conducted in KS, ND, WA, TX, OK, and MT.
66/ A crop group tolerance is inappropriate at the present time because use directions and tolerances must be submitted
and appropriate supporting residue data provided for bermuda grass, bluegrass, and bronegrass for fescue.
67/ The available data are not adequate to support the established tolerance for residues of azinphos-methyl in or on
grass forage and hay. Data depicting azinphos-methyl residues of concern in or on pasture grass and pasture grass hay
harvested 0 days following a single foliar application of appropriate formulations of azinphos-methyl at the maximum .
established use rate are required. Separate tests must be conducted using aerial and ground equipment. Tests should
be conducted in WI, NY, PA, MN, LA and MI.
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102
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
68/ A crop group tolerance is not appropriate at present because additional data are required for alfalfa and clover, the
representative commodities of this group.
69/ The available residue data indicate the established tolerances for alfalfa hay and forage are too low. New tolerance
levels cannot be proposed at this time because no data were submitted depicting residues resulting fron the registered
uses with a dust formulation. Data depicting azinphos-methyl residues of concern in or on alfalfa forage and hay:
(i) 21 days following a single application at 0.75 Ib ai/A; (ii) 16 days following a single application at 0.5 Ib
ai/A; (iii) 14 days after the second of two applications at 0.25 Ib ai/A; (iv) and 14 days after single application at
0.375 Ib ai/A are required. Separate tests must be conducted with D and WP or F1C formulations, and with aerial and
ground equipment. Tests should be conducted in CA, ID, IA, NE, NV, SD, UT, and WI. Tests frcm CA, UT, and NV must
include irrigated regions.
70/ No data were submitted to support the established tolerances for residues of azinphos-methyl in or on birdsfoot
trefoil forage and hay. However, no data are required since the requested data for clover will be translated to
birdsfoot trefoil.
71/ The available data are insufficient to support the established tolerances for residues of azinphos-methyl in or on
clover forage and hay. Data depicting azinphos-^nethyl residues of concern in or on clover forage and hay: (i) 21
days after a single application at 0.75 Ib ai/A; (ii) 16 days after a single application at 0.5 Ib ai/A; (iii) 14 days
after the last of two applications at 0.25 Ib ai/A; and (iv) 14 days after a single application at 0.375 Ib ai/A are
required. For determination of residues in.or on clvoer hay, separate tests must be conducted with D and WP or F1C
formulations and with aerial and ground applications. For determination of residues in clover forage, the same data
are required, except that tests depicting residues from ground applications of EC or WP formulations are not required.
Tests should be conducted in CA, KY, MO, NY, OK, PA, TN, and TX. Tests from CA must include irrigated regions.
72/ The submitted data are insufficient to support the established tolerance for residues of azinphos-methyl in or on
artichokes. Data depicting azinphos-methyl residues of concern in or on artichokes harvested 30 days following
multiple foliar applications of, in separate tests, a WP formulation and the 2 Ib/gal EC formulation at 1.5 Ib ai/A
are required. A maximum permissible number of applications per season or a maximum Ib ai/A/season rate must be
proposed and required tests must reflect the maximum seasonal rate proposed. Tests should be conducted in CA.
73/ No tolerance has been established or proposed pertaining to residues of azinphos-methyl in or on cotton forage. Since
cotton forage is a raw agricultural commodity, the registrant must either propose a tolerance for cotton forage and
provide the appropriate supporting residue data, or propose feeding and grazing restrictions. In addition, the
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103
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
submitted data are insufficient to support the established tolerance for residues of azinphos-methyl in or on cotton-
seed the following data are required:
a. Data depicting azinphos-methyl residues of concern in or on cottonseed following multiple foliar applications of
the 3 percent D formulation at 1 Ib ai/A. Foliar applications should begin prior to the normal time of disease
development and continue at regular intervals until 1 day prior to harvest. A maximum nimber of applications per
season or maximun Ib ai/A/season must be proposed and required data must reflect the proposed rate. Ground and
aerial equipment must be presented.
b. Data depicting azinphos-methyl residues of concern in or on cottonseed following multiple ULV applications of a
registered F1C formulation at 0.25 Ib ai/A. Foliar applications should begin at the normal time of bollweevil
infestation and be repeated at regular intervals until 1 day prior to harvest. A maximun nunber of applications
per season or maximum pounds ai/A/season must be proposed. Tests should be conducted in TX, CA, and MS.
74/ Data depicting residues in meal, hulls, and crude oil, refined oil and soapstock processed from cottonseed bearing
measureable weathered residues are required. If residues concentrate in any of these processed ccntnodities, appro-
priate food/feed additive tolerances must be proposed.
75/ A maximum number of applications per season or maximal seasonal rate must be submitted with the appropriate data. If
the proposed use rate "exceeds that reflected in the submitted data, then data depicting azinphos-methyl residues in or
on kiwi fruit following multiple foliar applications (at regular intervals) of the 50% WP formulation at 50 g ai/100 L
(using 2,200 L/Ha) until 14 days prior to harvest must be submitted.
76/ The available data are adequate to support the established tolerances for sugarcane and sugarcane bagasse and the
submitted data for residues in sugar and molasses are sufficient to show that azinphos-methyl residues do not concen-
trate in these processed products. No tolerance, however, has been established or proposed for residues of azinphos-
methyl in or on sugarcane forage. Since sugarcane forage is a raw agricultural commodity, you must either submit
labeling imposing feeding restrictions or propose a tolerance and provide data depicting azinphos-methyl residues of
concern in or on sugarcane forage following five broadcast applications by aircraft of a G formulation at 1 Ib ai/A
and, in separate tests, five foliar applications of EC and F1C formulations at 0.75 Ib ai/A. The last application
conducted in FL and LA.
77/ No data are available to assess the exposure of man to residues of concern of azinphos-methyl in or on tobacco and its
products. The following data are required:
a. Depictions of residues of concern in or on tobacco harvested at regular intervals until maturity, beginning six
days after the last of multiple foliar applications of a D, EC, or WP formulaton at 7-day intervals at 0.75 Ib
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104
TABLE A
GENERIC C&TA REQUIREMENTS FOR AZINPHO6-METHYL
§158.125 Residue Chemistry - Footnotes (cont'd)
ai/A. Applications must comierce immediately after transplanting or when pests first appear. Residue data are
required for both green and cured tobacco, and for tobacco smoke.
b. If total residues found in or on tobacco fron the above requested studies are > 0.1 ppm, then complete analytical
methods must be submitted for detecting and quantifying azinphos-methyl and all metabolites of concern in or on
tobacco and in tobacco smoke.
c. If total residues found in or on green tobacco are > 0.1 ppm then pyrolysis products from azinphos-methyl must be
characterized using ^^C-ring labeled azinphos-inethyl.
o All significant tobacco plant metabolites must be determined using l^C-ring labeled azinphos-methyl.
78/ The nature of the residue in ruminants is not adequately understood. The adequacy of the established tolerances
cannot be assessed, until the required residue data for the agricultural commodities and processed products o
animal feeds are submitted and reviewed.
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105
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement Test Use Does EPA Bibliographic
Substance Patterns Have Data? Citation
§158.130 Environmental Fate
DEGRADATION STUDIES-LAB:
161-1 - Hydrolysis TGAI or PAIRA A,B,G Yes 00029899
Photodegradat ion
161-2 - In water TGAI or PAIRA A,B,G, No
161-3 - On soil TGAI or PAIRA A,G No
161-4 - In Air TGAI or PAIRA A No
METABOLISM STUDIES-LAB:
162-1 - Aerobic Soil TGAI or PAIRA A,B,G Yes 00029900
162-2 - Anaerobic Soil TGAI or PAIRA A Yes 00029900
162-3 - Anaerobic Aquatic TGAI or PAIRA G No
MOBILITY STUDIES:
163-1 - Leaching and TGAI or PAIRA A,B,G Yes 00029885
Adsorpt ion/Da sorpt ion 00029887
163-2 - Volatility (Lab) TEP A No
163-3 - Volatility (Field) TEP A No
Must Additional
Data be
Submitted?
No
Yes
Yes
Reserved I/
No
No
Yes 5/
No
Reserved I/
Reserved I/
Time Frane
for
Submission
9 Months
9 Months
27 Months
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106
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Use Does EPA Bibliographic
Substance Patterns Have Data? Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
§158.130 Environmental Fate - Continued
DISSIPATION STUDIES-FIELD:
164-1 - Soil
164-3 - Forestry
164-5 - Soil, Long-term
ACCUMULATION STUDIES:
165-1 - Rotational Crops
(Confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - In Fish
165-5 - In Aquatic Non-Target
TEP A,B Yes 00144667
00144669
00144673
TEP G No
TEP A,B No
PAIRA A No
TEP A No
TEP A No
TGAI or PAIRA A,B,G Yes 00112146
TEP G No
No
Yes/5
No 2/
Yes
Reserve 3/
Yes 4/
No
Yes 5/
27 Months
39 Months
39 Months
12 Months
Organisms
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107
TABLE A
GENERIC DATA REQUIREMENTS FDR AZINPHOS-METHYL
§158.130 Environmental Fate - Continued
I/ Data reserved pending the outcome of reentry exposure and dissipation data requirements (132-1 - 133-4)
2/ Because of the low persistence of azinphos-^nethyl these data are not required.
3/ Reserved pending the result of the confined rotational crop study (165-1).
4/ Data will not be needed if the label contains a statment prohibiting use of water leaving treated field
for purposes of irrigating other crops.
5/ These data may be waived if forest use is removed fron the label, or if the use is defined as referring
to tree plantations that are not truly forest environments.
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108
TABLE A
GENERIC DATA REQUIREMENTS FDR AZINPHOS-METHYL
Date Requirement
Test Use Does EPA Bibliographic
Substance Patterns Have Data? Citation
Must Additional Time Frame
Data be for
Submitted Submission
§158.135 Toxicology
ACUTE TESTING:
81-1 - Acute Oral Toxicity - Rat TGAI
81-2 - Acute Dermal Toxicity
- Rabbit
TGAI
A,B
A,B
Yes
Yes
00155000
00155001
00155002
00155003
00155002
00155003
No
No
81-3 - Acute Inhalation Toxicity TGAI
- Rat
81-7 - Delayed
Neurotoxicity - Hen
SUBCHRONIC TESTING:
82-1 - 90-Day Feeding:
- Rodent, and
- Non-rodent (Dog)
TGAI
TGAI
A,B
A,B
No
No
A,B No
A,B . Yes
0083620
Yes
Yes
No I/
No 2/
9 Months
12 Months
82-4 - 90-Day Inhalation:
- Rat
IGAI
A,B
Yes
00155011
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109
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHQS-METHYL
Data Requirement Test Use Does EPA Bibliographic Must Additional Time Frame
Substance Patterns Have Data? Citation Data be for
Submitted? Submission
§158.135 Toxicology - Continued
CHRONIC
83-1 -
83-2 -
83-3 -
83-4 -
TESTING:
Chronic Toxicity - TGAI
2 species:
- Rodent, and A,B No - Yes
- Non-rodent (Dog) A,B Yes 00083620 No
Oncogenicity - TGAI
2 species:
- Rat (preferred) , and A,B Yes GS0235055 Yes 3/
- Mouse (preferred) A,B Yes GS0235055 No
Teratogenicity - TGAI
2 species:
- Rat A,B No - Yes
- Rabbit A,B No - Yes
Reproduction - Rat TGAI A,B No - Yes
50 Months
50 Months
15 Months
15 Months
39 Months
2-generation
MUTAGENICITY TESTING
84-2 - Gene Mutation (Ames Test) TGAI
84-2 - Structural Chromosomal TGAI
Aberration
A,B
A,B
No
No
Yes
Yes
9 Months
12 Months
84-4 - Other Genotoxic Effects TGAI
A,B
Yes
00155017
No
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110
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Use .Does EPA Bibliographic
Substance Pattern Have Data? Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
§158.135 Toxicology - Continued
SPECIAL TESTING
85-1 - General Metabolism
PAI or PAIRA
A,B
No
Yes
24 Months
I/ The required chronic toxicity will satisfy this requirement.
2/ The chronic toxicity study in dogs satisfies this requirement.
3/ The available rat data are inadequate and a rat oncogenicity study must be submitted.
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Ill
TABLE A
GENERIC DATA REQUIREMENTS FDR AZINPHOS-METHYL
Data Requirement
Test Use Does EPA Bibliographic Must Additional Time Frame
Substance Pattern Have Data? Citation Data be for
Submitted? Submission
§158.140 Reentry Protection
132-1 - Foliar Dissipation TEP
132-2 - Soil Dissipation TEP
133-3 - Dermal Exposure TEP
133-4 - Inhalation Exposure TEP
158.75 Other Exposure Data
- Glove Permeability I/
Study
A
A
A
A
A
No
No
No
NO
No
Yes
Yes
Yes
Yes
Yes
16 Months
27 Months
16 Months
16 Months
9 Months
/ A glove permeability study must be submitted using liquid and wettable powder formulations. The study must use several
different materials and must be conducted according to methods outlined in the "Standard Test Method for Resistance of
Protective Clothing Materials to Permeation by Hazardous Liquid Chemicals" by the American Society for Testing and
Materials. A protocol must be submitted to the Agency within 3 months of the issuance of the guidance document.
The permeability studies for the wettable powder formulations shall be conducted using the highest label permitted
spray solution concentration.
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112
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data
§158.
Requirement Test Use
Substance Pattern
.145 Wildlife and
Does EPA
Have Data?
Bibliographic Must Additional Time Frame
Citation Data be for
Submitted? Submission
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING
71-1
71-2
71-3
71-4
71-5
- Acute Avian Oral Toxic ity TGAI
- Avian Subacute Dietary TGAI
Toxic ity
- Upland Game Bird, and
- Waterfowl
- Wild Mammal Toxic ity TGAI
- Avian Reproduction TGAI
- Upland Game Bird, and
- Waterfowl
- Actual Field Testing TEP
- Mammals, and
- Birds
A,
A,
A,
A,
A,
A,
A,
A,
B,
B,
B,
B,
B,
B,
B,
B,
G
G
G
G
G
G
G
G
No
Yes
Yes
No
No
No
No
No
Yes
00034769 No
00034769 No
Yes
Yes
Yes
Yes
Yes
I/
2/
3/
3/
4/
V
9 Months
24 Months
24 Months
24 Months
48 Months
48 Months
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113
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Use Does EPA Bibliographic
Substance Pattern Have Data? Citation
Must Additional Time Frame
Data be for
Submitted? Submission
§158.145 Wildlife and
Aquatic Organisms - Continued
AQUATIC ORGANISM TESTING
72-1 - Freshwater Fish Toxicity TGAI
- Coldwater Fish Species,
and
- Warmwater Fish Species
- Freshwater Fish Toxicity TEP
- Coldwater Fish Species,
and
A,B,G Yes
A,B,G Yes
A,B,G Yes
GS0144012
GS0144012
00066046
GS0235005
No
No
No
72-2 -
- Warmwater Fish Species
Acute Toxic ity to TGAI
Freshwater Invertebrates
A,B,G Yes
A,B,G Yes
00066046
GS0144012
00068678
No
No
Acute Toxic ity to TEP
Freshwater Invertebrates
A,B,G
No
Yes 5/
9 Months
72-3 - Acute Toxic ity to
Estuarine and Marine
Organisms
- Fish
- Mollusk
- Shrimp
TGAI
A NO
A No
A No
Yes 6/
Yes 6/
Yes 6/
12 Months
12 Months
12 Months
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114
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data
§158
72-4
Requirement
.145 Wildlife and
Aquatic Organisms -
- Fish Early Life Stage
and
-Aquatic Invertebrate
Test Use
Substance Pattern
Continued
, TGAI A,B,G
TGAI A,B,G
Does EPA Bibliographic
Have Data? Citation
Yes 00145592
Yes 00143785
Must Additional
Data be
Submitted?
Yes 7/
No
Time Frame
for
Submission
15 Months
Life-Cycle
72-5 - Fish Life -Cycle
TGAI
A,B,G
No
Reserved 8/
72-6 - Aquatic Organism
Accumulation
72-7- Simulated or Actual
Field Testing for
Aquatic Organism
TGAI, PAI OR
Degradation
Product
TEP
A,B,G Yes
A,B,G - No
00112146
No
Yes 9/
24 Months
(Simulated Study)
' OR 48 Months
(Actual Study)
-------
115
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
{158.145 Wildlife and Aquatic Organisms - Continued
L/ A study meeting current guideline requirements is needed. Granule weight data for granular formulations is also
required.
2/ A five-day dietary study is required as per 40 CFR 158.145, to provide information on a species actually exposed in
the field, with a dietary feeding type of ingestion.
3/ Avian reproduction studies with technical azinphos-methyl are required by 40 CFR 158.145, since birds may be subjected
to repeated exposure preceding and/or during the breeding season. Current labeling permits applications for most
use sites and rates, often without specific restriction as to the number of such applications.
4/ Actual field testing with birds and mammals is required, as per 40 CFR 158. 145. With a typical non-granular
formulation, the initial sites to be tested (based on application rates and wildlife usage information)
include apple, cherry, and walnut orchards. Initial testing must include a study of dietary exposure and thorough
carcass searching to determine whether there is pesticide induced mortality, and if so, the extent. Research for the
apple site must also determine, by nest survey, whether avian breeding is disrupted, and collect complete natality,
mortality, emigration, and immigration data. It must be determined, by mark-recapture techniques, whether mammalian
populations are affected. Also required is a field study of broadcast application of the 10% granular formulation
in sugarcane at 1 Ib a.i./A, with carcass searching as described above. Multiple sites are required for all use
patterns studied. Additional field testing is reserved pending results of these studies. Cancellation of any of
the above use patterns would obviate the need for testing of these uses. However, depending on the outcome of the
above listed studies, other sites may be required. Protocols for conducting the studies must be submitted to the
Agency for review and approval within 6 months of the receipt of the guidance document.
5/ An acute toxicity study using an end use product with a freshwater invertebrate species is needed for hazard
evaluation since 1) the 1X59 of the technical grade of active ingredient is less than or equal to the estimated
environmental concentration (EEC) in the aquatic environment in modeled use patterns and 2) for forest use, there is
a potential for direct application to water under the forest'canopy (see 40 CFR 158.145).
-------
116
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
§158.145 Wildlife and Aquatic Organisms - Continued
6/ Acute toxicity studies with estuarine and marine organisms are needed because available runoff modeling information
and certain coastal area uses indicates a likelihood for exposure.
7/ The existing study did not find an overall no-effect level and raw data were not submitted for analysis. A new study
is required.
8/ This study is reserved pending submission and review of the required fish embryolarvae study.
9/ The Agency presumes substantial acute hazard from azinphos-methyl (see 40 CFR 154.7). Estimates of aquatic exposure
and measured field residues are greater than many acute 1X50 values, and aquatic field kills have been found. A
field monitoring study was required in a 5-3-82 EEB review, but this was in regard to a proposed corn use not
covered by this Standard. A simulated field study (mesocosm) was required in a 10-16-85 review, and should be
applicable to the use patterns covered by this Registration Standard, if conducted at appropriate loading rates. In
addition, aquatic field studies must be conducted on those registered sites for which greatest hazard may be
anticipated. These include sugarcane, potatoes, and blueberries, since the PIMS reports implicate these sites.
Cotton and soybeans should be included because of available modeling with these crops. A high application rate
orchard site such as walnuts should also be included. Pine forest is a substantially different use pattern that
should also be included in order to cover forestry uses. Aquatic residue monitoring (water column and sediments) is
required for all of these sites under "worst-case" situations (e.g., following rainfall). A full-scale aquatic field
study (examining effects on aquatic invertebrates and fish in addition to residue monitoring) is an alternative to a
mesocosm study and, if chosen, must be conducted on a cotton site since this is the largest use-site for this
pesticide. However, a mesocosm study, using both fish and aquatic invertebrates, is likely to be more applicable to
other registered sites. Additional residue monitoring and full-scale field studies are reserved pending results of
these studies. Cancellation of any of the above use patterns would obviate the need for testing of these uses.
However, since further studies are pending the results of the above initial testing, other sites may be required to
be substituted. Protocols for conducting the studies must be submitted to the Agency for review and approval within
6 months of the receipt of this document.
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117
TABLE A
GENERIC DATA REQUIREMENTS FOR AZINPHOS-METHYL
Data Requirement
Test Use Does EPA Bibliographic
Substance Pattern Have Data? Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
§158.155 Nontarget Insect
NONTARGET INSECT TESTING -
POLLINATORS;
141-1 - Honey bee acute
contact toxicity
141-2 - Honey bee - toxicity
of residues on
foliage
141-4 - Honey bee subacute
feeding study
141-5 - Field testing for
pollinators
NONTARGET INSECT TESTING -
AQUATIC INSECTS:
142-1 - Acute toxicity to
aqua t ic in sec t s
142-1 - Aquatic insect
life-cycle study
142-3 - Simulated or actual
field testing for
aquatic insects
TGAI
TEP
A,B,G,H Yes
A,B,G,H No
00066220
05004151
TEP
A,B,G,H No
No
Yes I/
(Reserved) 2/
No 3/
(Reserved) 4/
(Reserved) 4/
(Reserved) 4/
15 Months
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118
TABLE A
GENERIC DATA REQUIREMENTS FDR AZINPHOS-METHYL
Data Requirement Test Use Does EPA Bibliographic Must Additional Time Frame
Substance Pattern Have Data? Citation Data be for
Submitted? Submission
143-1 - NONTARGET INSECT , (Reserved) 4/
thru TESTING - PREDATORS
143-3 AND PARASITES
I/ As data from the acute study indicate high toxicity to honeybees, data on residual toxicity are required.
2/ Reserved pending development of test methodology.
3/ Requirement for field testing is imposed only on a case-by-case basis. Data reviewed to date do not indicate the need
for a field study.
4/ Reserved pending the Agency decision as to whether the data requirement should be established.
-------
119
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING AZINPHOS-METHYL
Data Requirement
§158.120 Product Chemistry
Product Identity:
Test Use Does EPA
Substance Pattern Have Data?
I/
Bibliographic
Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
61-1 - Product Identity and MP
Disclosure of
Ingredients
61-2 - Description of Beginning MP
Materials and
Manufacturing Process
61-3 - Discussion of Formation MP
of Impurities
Analysis and Certification of Product
Ingredients
All
All
All
No
No
No
Yes 2/
Yes 2/
Yes 2/
6 Months
6 Months
6 Months
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods to Verify
Certified Limit
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
MP
MP
MP
MP
MP
MP
All
All
All
All
All
All
No
No
No
No
No
No
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
12 Months
12 Months
12 Months
6 Months
6 Months
6 -Months
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120
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING AZINPHOS-METHYL
Data
§158.
Requirement Test
Substance
Use Does EPA Bibliographic Must Additional Time Frame
Pattern Have Data? Citation Data be for
I/ Submitted? 2/ Submission
120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
63-7
63-12
63-14
63-15
63-16
63-17
63-18
63-19
63-20
- Density, Bulk Density, or
Specific Gravity
- pH
- Oxidizing or Reducing
Action
- Flammability
- Explodability
- Storage Stability
- Viscosity
- Miscibility
- Corrosion Characteristics
MP
MP
MP
MP
MP
MP
MP
MP
MP
All
All
All
All
All
All
All
All
All
No
No
No
No
No
No
No
No
No
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
Yes 2/
7 Months
7 Months
7 Months
7 Months
7 Months
16 Months
7 Months
7 Months
7 Months
I/ Although product chemistry data may have been submitted in the past, the Agency has determined that these data must
be resubmitted for each manufacturing use product. New requirements have been introduced and previously submitted
data must be updated. Therefore bibliographic citations for the old data are not applicable.
2/ Product Specific data are required tor the following formulations: EPA REG. NO. 3125-108, EPA REG. NO. 11678-4,
EPA REG. NO. 2749-291, EPA REG. NO. 10163-95, EPA REG. NO. 3125-225, EPA REG. NO. 3125-153, EPA REG. NO. 3125-223.
-------
121
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING AZINPHOS-METHYL
Data
§158.
t
Requirement Test Use Does EPA Bibliographic
Substance Pattern Have Data? Citation
135 Toxicology
Must Additional
Data be
Submitted? I/
Time Frame
for
Submission
ACUTE TESTING
81-1
81-2
81-3
81-4
81-5
81-6
- Acute Oral Toxicity - Rat MP All No
- Acute Dermal Toxicity MP All No
- Rabbit
- Acute Inhalation Toxicity MP All No
- Rat
- primary Eye MP All No
Irritation - Rabbit
- Primary Dermal MP All No
irritation - Rabbit
- Dermal Sensitization - MP All No
Guinea Pig
Yes I/
Yes I/
Yes I/
Yes I/
Yes I/
Yes I/
9 Months
9 Months
9 Months
9 Months
9 Months
9 Months
I/ Product Specific data are required for the following formulations: EPA REG. NO. 3125-108, EPA REG. NO. 11678-4,
EPA REG. NO. 2749-291, EPA REG. NO. 10163-95, EPA REG. NO. 3125-225, EPA REG. NO. 3125-153, EPA REG. NO. 3125-223.
-------
122
TABLE C
PRODUCT SPECIFIC DATA REQUIREMENTS FOR END-USE PRODUCTS CONTAINING AZINPHOS-METHYL
Data Requirement
Test
Substance
Use
Pattern
Does EPA
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
§158.135 Toxicology
ACUTE TESTING
81-1 - Acute Oral Toxicity EP All No
81-2 - Acute Dermal Toxicity EP ' All No
81-3 - Acute Inhalation Toxicity EP All No
Reserved I/
Yes I/, 2/ 9 Month
Yes I/, 2/ 9 Month
I/ These data are required if the Toxicity Category I classification is challenged.
2/ In order to determine whether to impose restricted use classification, data are required on all end-use products.
(These data will- be waived if the registrants chooses to restrict the product and classify their products are Toxicity
category I).
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123
SUMMARY-1
LABEL CONTENTS '
40 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling. Specific label items listed
below are keyed to the table at the end of this Appendix.
Item 1. PRODUCT NAME - The name, brand or trademark is
required to be located on the front panel, preferably centered
•in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
Item 3. NET CONTENTS - A net contents statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text. The net contents must be expressed in the
largest suitable unit, e.g., "1 pound 10 ounces" rather than
"26 ounces." In addition to English units, net contents may
be expressed in metric units. [40 CFR 162.10(d)]
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "EPA Registration No.," or "EPA
Reg. No." The registration number must be set in type ot a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency.
[40 CFR 162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishmeni-
Viumber, preceded by the phrase "EPA Est." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the immediate
container cannot be clearly read through such wrapper or container.
[40 CFR 162.10(f)]
Item 6A. INGREDIENTS STATEMENT - An ingredients statement
is required on the front panel. The ingredients statement must
contain the name and percentage by weight of each active ingredient
and the total percentage by weight of all inert ingredients.
The preferred location is immediately below the product name.
The ingredients statement must run parallel with, and be clearly
distinguished from, other text on the panel. It must not be
placed in the body of other text. [40 CFR 162.10(g)]
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124
SUMMARY-2
Item 6B. POUNDS PER GALLON STATEMENT - For liquid agricul-
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label Signal Word "Keep Out of Reach
on Front Panel Minimum Type Size of Children"
in Square Inches All Capitals Minimum Type Size
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - The statement
"Keep Out of Reach of Children" must be located on the front
panel above the signal word except where contact with children
during distribution or use is unlikely. [40 CFR 162 .10(h)(1)(ii]
Item 7B. SIGNAL WORD - The signal word (DANGER, WARNING,
or CAUTION) is required on the front panel immediately below
the child hazard warning statement. [40 CFR 162.10 (h)(l)(i)}
Item 7C. SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word "Poison" shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON. [40 CFR 162.10(h)(1)(i)]
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
•II, and III. [40 CFR 162.10(h)(1)(lii)]
Item 7E. REFERRAL STATEMENT - The statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
[40 CFR 162.10(h)(l)(iii)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. [40 CFR 162.10(h)(2)].
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125
SUMMARY-3 •
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage. [40 CFR 162.10(h)(2)(i)]
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. [40 CFR 162.10(h)(2)(ii)]
Item 8C. PHYSICAL OR CHEMICAL HAZARD - FLAMMABILITY
Precautionary statements relating to flammability of a product
are required to appear on the label if it meets the criteria
in the PHYS/CHEM Labeling Appendix. The requirement is
based on the results of the flashpoint determinations and
flame extension tests required to be submitted for all products.
These statements are to be located in the side/back panel
precautionary statements section, preceded by the heading
"Physical/Chemical Hazards." Note that no signal word is
used in conjunction with the flammability statements.
Item 9A. RESTRICTED USE CLASSIFICATION - FIFRA sec. 3(d)
requires that all pesticide formulations/uses be classified
for either general or restricted use. Products classified
for restricted use may be limited to use by certified applicators
or persons under their direct supervision (or may be subject
to other restrictions that may be imposed by regulation) .
In the Registration Standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section IV
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.
The Regulatory Position and Rationale states whether
'products containing this active ingredient are classified
for restricted use. If they are restricted the~draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).
If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for reregistration. During
the Agency's review of your application, your proposed classi-
fication determination will be evaluated in accordance with
the provisions of 40 CFR 162.11(c). You will be notified of
the Agency's classification decision.
-------
126
SUMMARY-4
Classification Labeling Requirements
If your product has been classified for restricted use,
the following label requirements apply:
1. All uses restricted.
a. The statement "Restricted Use Pesticide" must
appear at the top of the front panel of the label. The
statement must be set in type of the same minimum size
as required for human hazard signal word (see table in 40
CFR 162.10(h)(1)(iv)
b. Directly below this statement on the front panel,
a summary statement of the terms of restriction must
appear (including the reasons for restriction if specified
in Section I). If use is restricted to certified applicators,
the following statement is required: "For retail sale
to and use only by Certified Applicators or persons
under their direct supervision and only for those uses
covered by the Certified Applicator's Certification."
2. Some but not all uses restricted. If the Regulatory
Position and Rationale states that some uses are classified
for restricted use, and some are unclassified, several courses
of action are available:
a. You may label the product for Restricted use.
If you do so, you may include on the label uses that
are unrestricted, but you may not distinguish them
on the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit dratt labeling bearing only unrestricted
uses.
c. You may "split" your registration, i.e., register
two separate products with identical formulation?, one
* bearing only unrestricted uses, and the other bearing
restricted uses. To do so, submit two applications for
reregistration, each containing all forms and necessary
labels. Both applications should be submitted simul-
taneously. Note that 'the products will be assigned
separate registration numbers.
Item 9B. MISUSE STATEMENT - All products must bear the
misuse statement, "It is a violation of Federal law to use
this product in a manner inconsistent with its labeling."
This statement appears at the beginning of the directions
for use, directly beneath the heading of that section.
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127
SUMMARY-5
Item 10A. REENTRY STATEMENT - If a reentry interval
has been established by the Agency, it must be included on
the label. Additional worker protection statements may be
required in accordance with PR Notice 83-2, March 29, 1983.
Item 10B. STORAGE AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. These instructions must be grouped and
appear under the heading "Storage and Disposal" in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warning. Refer to Appendix II,
STOR, PEST/DIS, and CONT/DIS to determine the storage and
disposal instructions appropriate for your products.
Item IOC. DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment.
[40 CFR 162.10]
COLLATERAL LABELING
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other written or graphic printed matter which is
referred to on the label or which is to accompany the product
are termed collateral labeling. Such labeling may not bear
claims or representations that differ in substance from those
accepted in connection with registration of the product. It
should be made part of the response to this notice and submitted
for review.
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128
SUMMARY-6
LABELING REQUIREMENTS OF THE FIFRA, AS AMENDED
ITEM
1
2
3
4
5
6A
6B
7
7A
7B
LABEL ELEMENT
Product name
Company name
and address
Net contents
EPA Reg. No.
EPA Est. No.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/uni't area
All products
All products
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel ,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediately
below child
hazard
warning
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . .,"
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type size and run
parallel to other type.
May appear on the container instead of
the label .
Text must run parallel with other text
on the panel .
All front panel precautionary statements
must be grouped together, preferably
blocked .
Note type size requirements.
Note type size requirements.
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129
SUMMARY-7
ITEM
7C
7D
7E
8
8A
8B
LABEL ELEMENT
Skull & cross-
bones and word
POISON (in red)
Statement of
Practical
Treatment or
First Aid
Referral
statement
Side/back panel
precautionary
statements
Hazards to
hunans and
domestic
animals
Environmental
hazards
APPLICABILITY
OF REQUIREMENT
All products
which ate Cat-
egory I based
on oral , der-
mal , or inhala-
tion toxicity
All procucts
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, II, and III
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
Category I :
Front panel
unless refer-
ral statement
is used.
Others :
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
PREFERRED
Both in close
proximity to
signal word
Front panel
for all .
Top or side
of back panel
preceding
directions
for use
Same as above
Same as above
COMMENTS
Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must be preceded by appropriate signal
word.
Environmental hazards include bee
caution where applicable.
-------
SUMMARY-8
ITEM
8C
9A
9B
10A
10B
IOC
LABEL ELEMENT
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Reentry
statement
Storage and
disposal block
Directions
for use
APPLICABILITY
OF REQUIREMENT
All pressurized
products, others
with flash
points under
150°F
All restricted
products
All products
PR Notice 83-2
or as determined
by the Agency
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
heading of
directions
for use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked
Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS
Refer to Appendix II guide
PHYS/CHEM
Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be. same type size as
signal word.
Required statement is:
"It is a violation of Federal law
to use this product in a manner
inconsistent with its labeling."
Must be set apart and clearly distin-
guishable from from other directions
for use.
Refer to Appendix II guides STOR,
CONT/DIS, and PEST/DIS for further
information and required statements.
May be in metric as well as U.S. units
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131
Chapter I—Environmental Protection Agency
obtained the data from anothe
(Identify); applicant copied dajf
frbm a publication: applicant obt
a dopy of the data from EPA).
(a) The applicant shall submit
his application a statement that
in Jta evaluation of the properties/
cacyAand safety of the formv
end-use product, may not consic
data is supporting the appl
except the following data:
(1) TAe data the applicant fias sub-
mitted tk EPA under
this sectlbn:
(2) Otter data pe
safety of the product's
ents, rather than to the
end-use product; and
(3) Existing tolerances,
regulations, \exemptioi
clearances issued unde:
Food, Drug, and Canoe
(e) 11 the applicant
item of data he, sul
section was gen<
pense of) anothe:
ly submitted the
predecessor. USD.
ary 1. 1970. to sui
for registration.
permit, or amen
use to an exis
rereglstration (
and the o:
reached writ
(b) of
to the
Ve ingredi-
lety of the
'ood additive
and other
the Federal
[c Act.
tows that any
ted under this
y (or at the ex-
who original-
to EPA (or Its
oh or after Janu-
an application
ixperlmental use
nt adding a new
.tlon. or for
the applicant
data\submltter have
ment on the
amount and Uw terms \pf payment of
any compensation than may be pay-
able under FIFRA section
3(cXlXDXil)/wlth regard to approval
of the application), the applicant shall
submit to EPA a statement that he
has fumiaaed to each such, identified
original data submitter
(DA notification of the applicant's
intent to/apply for registration, includ-
ing the Proposed product i
(2) An offer to pay the penvn com-
pensation, with regard to the approval
of the/ application, to the extent re-
by FTFRA sections 3(c) 1(2.10 Labeling reqainnMnU.
(a) Genera/—(1) Content* of the
label Every pesticide products shall
bear a label containing the Informa-
tion specified by the Act. and the refu-
tations in this Part. The contents of A
label mutt show clearly and promi-
nently the following:
(1) The name, brand, or trademark
under which the product is sold as pre-
scribed In paragraph (b) of this sec-
tion:
(11) The name and address of the
producer, registrant, or person for
whom produced as prescribed In para-
graph (c) of this section:
(ill) The net contents as prescribed
in paragraph (d) of this section;
-------
132
$ 162.10
(Iv) The product registration
number u prescribed In paragraph (e)
of thli section;
(v> The producing establishment
number u prescribed In paragraph <()
of thU tecllon;
(vl) An Ingredient aUtement a» pre-
scribed In paragraph (R) of this sec-
tion;
(vll) Warning or precautionary state-
ments M prescribed In paragraph (h)
of this section:
(vlll) The directions for use aa pre-
scribed In paragraph (I) of this section:
and
(Ix) The use classification^) as pre-
scribed In paragraph (J) of this section.
(3) Prominence and lesribUitv. (I) All
words, statements, graphic representa-
tions, designs or other Information re-
quired on the labeling by the Act or
the regulations In this part must be
clearly legible to a person with normal
vision, and must be placed with such
consplcuousneas (M compared with
other words, statements, designs, or
graphic matter on the labeling) and
expressed In such terms u to render It
likely to be read and understood by
the ordinary Individual under custom-
ary conditions of purchase and use.
(II) All required label Uxt must:
(A) Be set In 0-polnt or larger type:
(B) Appear on a clear contrasting
background: and
Non-numerical and/or compara-
tive statements on the safely of the
product. Including but not limited to:
(A) "Contains all natural Ingredi-
ents";
(B) "Among the least toxic chemi-
cals known"
"Pollution approved"
(•> Final printed labeling. (I) F.xcept
as provided In paragraph (aH6)(ll> of
this section, final printed labeling
must be submitted and accepted prior
to registration. However, final printed
labeling need not be submitted until
draft label texts have been provision-
ally accepted by the Agency.
(II) Clearly legible reproductions or
photo reductions will be accept »d for
unusual labels such as those silk-
screened directly onto glass or metal
containers or large bag or drum labels.
Such reproductions must be of micro-
film reproduction quality.
(b) Namtr brand, or trademark. (1)
The name, brand, or trademark under
which the pesticide product la sold
shall appear on the front panel of the
label.
(2) Ho name, brand, or trademark
may appear on the label which:
(I) Is false or misleading, or
(II) Has not been approved by the
Administrator through registration or
supplemental registration as an addi-
tional name pursuant to I 162.0(bM4>.
(conf tnued)
} 1*7.10
(c) Name and address of producer.
registrant, or person for whom pro-
duced. An unqualified name and ad-
dress given on the label shall be con
sldered as the name and address of I he
producer. If the registrant's name ap-
pears on the label and the registrant Is
not the producer, or If I he name of the
person for whom the pesticide was
produced appears on (he lubcl. II must
be qualified by appropriate wording
such as "Packed for * * V "Distribut-
ed by • • V or "Sold by In show
that the name Is no) Hint of Hie pro-
ducer.
(d) Net vtfiohl or mra.iure af con-
tent*. (I) The net weight or measure
of content shall bo exclusive of wrap
pers or other materials and shall be
the average content unless explicitly'
staled as a minimum quantity.
(2) If the pesticide Is a liquid, the
net content statement shall be In
terms of liquid measure at AD* F (20'C>
and shall be expressed In conventional
American units of fluid ounce*, pints.
quarts, and gallons.
(3) If the pesticide Is solid or semlso-
ltd, viscous or pressurized, or Is a mix-
ture of liquid and solid, the net con-
tent statement shall be In terms of
weight expressed as avoirdupois
pounds and ounces.
(4) In all cases, net content shall he
stated In terms of the latest suitable
units. I.e., "I pound 10 ounces" rather
than "30 ounces."
(5) In addition to the required units
specified, net content may be ex-
pressed In metric units.
(0) Variation above minimum con-
tent or around an average Is permissi-
ble only to the extent that It repre-
sents deviation unavoidable In good
manufacturing practice. Variation
below a stated minimum Is not permit-
ted. In no case shall the average con-
tent of the packages In a shipment fall
below the stated average content.
(e) Product rtsriitrattnn number.
The registration number assigned to
the pesticide product at the time of
registration shall appear on the label.
preceded by the phrase "EPA Regis-
tratlon No.," or the phrase "EPA Reg.
No." The registration number shall be
set In type of a sice and style similar to
other print on that part of the label
on which It appears and shall run par-
-------
133
{ 14X10
allel to It The registration number
and the required Identifying phrue
•hall not appear In iuch a manner at
to suggest or Imply recommendation
or endorsement of the product by the
Acency.
(fl Producing ettabltihmentt regii-
(radon number. The producing estab-
lishment registration number preced-
ed by the phrase "EPA Est.". of the
final establishment at which the prod-
uct was produced may appear In any
suitable location on the label or Imme-
diate container. It must appear on the
wrapper or outside container of the
package If the EPA establishment reg-
istration number on the Immediate
container cannot be clearly read
through such wrapper or container.
<•) Ingredient itatemtnt—(1) Gener-
al The label of each pesticide product
must bear a statement which contains
the name and percentage by weight of
each active Ingredient, the total per-
centage by weight of all Inert Ingredi-
ents: and If the pesticide contains ar-
senic In any form, a statement of the
percentages of total and water-soluble
arsenic calculated as elemental ar-
senic. The active Ingredients must be
designated by the term "active Ingredi-
ents" and the Inert Ingredients by the
term "Inert Ingredients." or the singu-
lar forms of these terms when appro-
priate. Both terms shall be In the
same type size, be aligned to the same
margin and be equally prominent. The
statement "Inert Ingredients, none" Is
not required for pesticides which con-
tain 100 percent active Ingredients.
Unless the Ingredient statement Is a
complete analysis of the pesticide, the
term "analysis" shall not be used as a
heading for the Ingredient statement.
(2) Position of ingredient ttatemenL
(I) The Ingredient statement Is nor-
mally required on the front panel of
the label. If there Is an outside con-
tainer or wrapper through which the
Ingredient statement cannot be clearly
read, the Ingredient statement must
also appear on such outnlde container
or wrapper. If the sice or form of the
package makes It Impracticable to
place the Ingredient statement on the
front panel of the label, permliulon
may be granted for the Ingredient
statement to *ppear elsewhere.
Till* 40—rV*Uc1l*fl «.f Environment
(II) The text of the Ingredient state-
ment must run parallel with other
text on the panel on which It appears.
and must be clearly dlstlngu:;hable
from and must not be placed In the
body of other text.
<3) N*met to be vted in Ingredient
itatemenL The name used for each In-
gredient shall be the accepted
common name. If there Is one. fol-
lowed by the chemical name. The
common name may be used alone only
If It Is well known. If no common name
has been established, the chemical
name alone shall be used. In no cane
will the use of a trademark or propri-
etary name be permitted unless such
name has been accepted as a common
name by the Administrator under the
authority of Section 35(cXfl>.
M) Statement! of percentage*. The
percentages of Ingredients shall be
stated In terms of welght-lo-welght.
The sum of percentages of the active
and the Inert Ingredient* shall be 100.
Percentages shall not be expressed by
a range of values such as "M-55%.1 If
the use* of the pesticide product are
expressed as weight of active Ingredi-
ent per unit area, a statement of the
weight of active Ingredient per unit
volume of the pesticide formulation
shall also appear In the Ingredient
statement.
IB) Accuracy of slated percentage*.
The percentage* given shall be as pre-
cise as possible reflecting good manu-
facturing practice. If there may be un-
avoidable variation between manufac-
turing batches, the value stated for
each active Ingredient shall be the
lowest percentage which may be pres-
ent
46) Deterioration. Pesticides which
change In chemical composition sig-
nificantly must meet the following la-
beling requirements:
(I) In cases where It Is determined
that a pesticide formulation changes
chemical composition significantly.
the product must bear the following
statement In a prominent position on
the label: "Not for sale or use after
tdalel."
(II) The product must meet all label
claims up to the expiration time Indi-
cated on the label.
(7) Inert Ingredient*. The Adminis-
trator may require the name of any
Oi«pt«r I—Environmental Protection Agency
(continued)
9 147.10
Inert IngredlenKs) to be listed In the
Ingredient Htalement If tin determine*
that such Ingredient!*) may pose a
hazard to man or the environment.
(h) Warning! and precautionary
statement*. Required warnings and
precautionary statements concerning
the general area* of loxlcologlcal
hazard Including hazard to children.
environmental hazard, and physical or
chemical hazard full Into two groups;
those required on the front panel of
the labeling and I hose which may
appear elsewhere. Sperlflr require
menta concerning content, placemen!.
type size, and prominence are given
below.
(I) Required front fxtnr/ tlatrmrnt*.
With the except Ion of the child
hazard warning statement, the text re-
quired on the fronl pane) of I he label
In determined by the ToxIcily Catego-
ry of the pmtlclde: The category Is aa-
signed on the biwls of I he highest
hazard shown by any of the Inrllcnlor*
In the table below
CM ID.
I
lip to ml *r*ng V)
1
t*> to «-«l *d«»^ JIXt
r
From n »*v MO mf/V,)
tOO fhrv WOO
fnjm MO Uni won i«g/
kfl
Fmli J On 70 iKCMn
rram J.ooo »*v xi ooo
, (I) Human hazard slqnal word—(A)
Toilcltv Category I. All pesticide prod-
ucts meeting the criteria of Toxlclty
Category I shall bear of), the front
panel the signal word "Danger." In ad-
dition If the product was assigned to
Toxlclty Category I on the basts of Its
oral. Inhalation or dermal toxlclty (as
distinct from skin and eye local ef-
fects) the word "Poison" shall appear
In' red on a background of distinctly
contrasting color and the skull and
croKHbones shall appear In Immediate
proximity to the word "poison."
(B) Toxlcitv Category II. All pesti-
cide products meeting the criteria of
Toxlclty Category II shall bear on the
front panel the signal word "Warn-
ing."
(Cl Toxlcitv Category III. All pesti-
cide products meeting the criteria of
Toxlclty Category III shall bear on
the front panel the signal word "Cau-
tion."
ID) Toilrltv Category IV. All pesti-
cide product* meeting the criteria of
Toxlclly Category IV shall bear on the
fronl panel the signal word "Caution."
IE) t/je of slqnal wnrdi. Use of any
signal worri(s) associated with a higher
Toxlclty Category IK not permitted
except when the Acenry determine*
that such labeling Is necessary to pre
vent unreasonable adverse effect* on
man or the environment. In no rase
shall more than one human hazard
signal word appear on the front panel
of a label.
(II) Child flocanf warning Every pen
tlclde product label shall bear on the
front panel the statement "keep out of
reach of children." Only In case*
where the likelihood of contact with
children during distribution, market-
ing, storage or use Is demonstrated hy
the applicant to be extremely remote.
or If the nature of the pesticide Is such
that It Is approved for use on InfanU
or small children, may the Administra-
tor waive this requirement.
(Ill) Statement of practical treat-
ment—(A) Toilcltv Category I. A
statement of practical treatment (first
aid or other) shall appear on the fronl
panel of the label of all pesticide* fall
Ing Into Toxlclty Category I on the
basis of oral. Inhalation or dermal tox-
lclty. The Agency may, however.
permit reasonable variations In (he
placement of the statement of prucll
-------
134
{ 16X10
cal treatment U some reference such
as "See statement of practical treat-
ment on back panel" appears on the
front panel near the word "Poison"
and the skull and crossbonea.
(B) Other toxicity cateyoriei. The
statement of practical treatment Is not
required on the front panel except as
described In paragraph (hXlMIIIHA) of
this section. The applicant may. how-
ever. Include such a front panel state-
ment at his option. Statements of
practical treatment are. however, re-
quired elsewhere on the label In
accord with paragraph (hMl) of this
section If they do not appear on the
front panel.
(Iv) Placement and prominence. All
the require front panel warning state-
ments shall be grouped together on
the label, and shall appear with suffi-
cient prominence relative to other
front panel text and graphic material
to make them unlikely to be over-
looked under customary conditions of
purchase and use. The following table
shows the minimum type size require-
ments for the front panel warning
statements on various sizes of labels:
Till* 40—froUctlon of Invlrenmvnl
•n ol I(M tort POM! •>•»•>*
hK*M
I wd ir*»
rot
Ro»**d
jar-
0***
«
10
It
14
II
*
-Kxpoul
olnocrioi
CMtton
1
*
1
10
If
(2) Other required learning! and pre-
cautionary statement*. The warnings
and precautionary statements as re-
quired below shall appear together on
the label under the general heading
"Precautionary Statements" and
under appropriate subheadings of
"Hazard to Humans and Domestic Ani-
mals." "Environmental Hazard" and
"Physical or Chemical Hazard."
(I) HaMard to numan* and domeiUc
animals. (A) Where a hazard exist* to
humans or domestic animals, precau-
tionary statements are required Indi-
cating the particular hazard, the
route(s) of exposure and the precau-
tions to be taken to avoid accident.
Injury or damage. The precautionary
paragraph shall be Immediately pre-
ceded by the appropriate hazard signal
word.
(B) The following table depicts typi-
cal precautionary statements. Trtece
statements must be modified or ex-
panded to reflect specific hazards.
tooufh ittil. Do not krootto i
•OMl. Do not ft •> •*•«. on i
•I I
MMonl Do «ot •ol kl 0(00. on o>*\ or on
»>«*•> Woor ootCFM or too oMoM on4 (Ubboi
Itono — MaofcoMHiiioMor HM • I
tA0pPMproMi) ••! (M •*MH*tv4 Msjjol
0*100 «p> Ion* «*>| > «rin. Do i
On ot*v or on t»j»*io, l»»oj I inolu n|. Iff.
fcoloMlbl mnojllf
I «*>i ol*v «r» «r Ju««'» •> OOM W
i«ilil, «uot> oro» oi 0>* »•» •**, el
n*»p
(II) Snvtronmentat hatardt. Where a
hazard exists to non target organisms
excluding humans and domestic ani-
mals, precautionary statements are re-
quired slating the nature of the
hazard and the appropriate precau-
tion* In nvnlrl r."t."ll-l M-~l
Injury or damage. Example* of the
hazard statements and the circum-
stances under which they are required
follow:
(A) If a pesticide Intended for out-
door use contains an active Ingredient
Chapter I—Environmental Protection Agency
(continued)
§ IM 10
100 or less, the statement "This Pesti-
cide Is Toxic to Wildlife" Is required.
(B) If a pesticide Intended for out-
door use contains an active Ingredient
with a fish acute LCM of 1 ppm or less,
the statement "This Pesticide Is Toxic
to Fish" Is required.
(C) If a pesticide Intended for! out-
door use contains an active Ingredient
with an avlan acute oral LD» of 100
mg/kg or less, or a subacute dietary
LC». of 500 ppm or less, the statement
"This Pesticide Is Toxic to WIMIIfe" Is
required.
H either accident history or field
studies demonstrate that use of the
pesticide may result In fatality to
birds, fish or mammals, the statement
"This pesticide Is extremely toxic In
wildlife (fish)" Is required.
(R) For uses Involving foliar applica-
tion to agricultural crops, forests, or
shade trees, or for mosquito' abate-
ment treatment-*, pesticide* toxic to
pollinating Inserts must bear approprl
ate label cautions.
(F> For all outdoor usm other than
aquatic applications I he label must
bear the caution "Keep out of lakes.
ponds or streams. Do not contaminate
water by cleaning of equipment or dlv
posal of wastes."
(Ill) fAy.ticaf or chemical harani*.
Warning statement.* on the flammahll
Ity or explosive chnrarlerlstlm ol I he
pesticide are required as follows-
|A| na
Flo* POM « or brioo XT F. • •—. »
FlMh «*4 »t*~« 70' F xW nrt oxr XT T or • *>•
IIO' r *n*v r«,r«>
•p«rhf. Mntf Op«n Horn* Do net p«
OV« 110' F
Do nol vw or »to
Horn*. Oo not pwic*ur« or hir>*r«M
ISO" * -
F •f«vw»« lo
aq
A6o» KT f on* nol
(I) IMrectfoni /or l/«e—(1) General
reoulrementi—vlrl»H tv..t-
(A) If required by the Agency, such
printed or graphic matter Is securely
attached to each package of the pesti-
cide, or placed within the outside
wrapper or bag:
(B) The label bears a reference to
the directions for use In accompanying
leaflets or circulars, such as "See di-
rections In the enclosed circular:" and
(C) The Administrator determines
that It Is not necessary for such dlrec
tlons to appear on the label.
(Ill) Exception* to requirement for
direction for tut—(At Detailed direr
tlons for use may be omitted from la
bellng of pesticides which are Intended
for use only by manufacturers of print-
ucls other than pesticide products In
their regular manufacturing prnrrssc*.
-------
135
§ 16X10
(/) The label clearly shows that the
product I* Intended for use only In
manufacturing processes and specifies
the type(s) of product* Involved.
(2) Adequate Information such M
technical data sheet* or bulletins. Is
available to the trade specifying the
type of product Involved and IU
proper use In manufacturing process-
es;
(J) The product will not come Into
the hands of the general public except
after Incorporation Into finished prod-
ucts: and
<4) The Administrator determines
that such directions are not necessary
to prevent unreasonable adverse ef-
fects on man or the environment.
(B) Detailed directions tor use may
be omitted from the labeling of pesti-
cide products for which sale ls limited
to physicians, veterinarians, or drug-
gists, provided that:
(I) The label clearly state* that the
product Is for use only by physicians
or veterinarians;
(2) The Administrator determine*
that such directions are not necessary
to prevent unreasonable adverse ef-
fect* on man or the environment; and
(J) The product ls also a drug and
regulated under the provisions of the
Federal Pood. Drug and Cosmetic Act.
of pesticide prod-
uct* Involved;
(J) The product a* finally manufac-
tured, formulated, mixed, or repack-
aged I* registered; and
(4) The Administrator determines
that such directions are not necessary
to prevent unreasonable advene ef-
fects on man or the environment.
40 — fr«t>ctUn «f f nvkwimont
Content* of Directions for U*e.
The direction* for use shall Include
the following, under the headings "Di-
rection* for Use":
(I) The statement of use classifica-
tion as prescribed In 162.KMJ) Immedi-
ately under the heading "Directions
for Use."
(II) Immediately below the state-
ment of use classification, the state-
ment "It to a violation of Federal law
to use this product In a manner Incon-
sistent with It* labeling."
The slte The target pesUs) associated
with each *lle.
(v) The dosage rate associated with
each site and pest.
(vl) The method of application. In-
cluding Instruction* for dilution. If re-
quired. and typei*) of application ap-
paratus or equipment required.
(vll J The frequency and timing of ap-
plication* necessary to obtain effective
renulU without causing unreasonable
advene effect* on the environment.
(vlll) Specific limitations on reentry
to area* where the pevlfctde ha* been
applied, meeting the requirements
concerning reentry provided by 40
CFR Part 170.
(lx> Specific direction* concerning
the storage and disposal of the pesti-
cide and It* container, meeting the re-
quirement* of 40 CFR Part 106. These
Instructions shall be grouped and
appear under the heading "Storage
and Disposal." This heading must be
set In type of the same minimum she*
a* required for the child hasard warn-
ing (See Table In | lOI.HMhMIMtv).)
(x) Any limitation* or reatrlctlo.;* on
use required to prevent unreasonable
advene effects, such M:
(A) Required Interval* between ap-
plication and harvest of food or feed
crop*.
(B) Rotational crop restriction*.
(C) Warning* a* required against use
on certain crop*, animals, object*, or
In or adjacent to certain area*.
(D) (Reserved)
(E) For restricted use pesticides, a
statement that the pesticide may be
applied under the direct supervision of
a certified applicator who U not phys-
ically present at the site of apr':catlon
Chapter I—Environmental Protection
but nonetheless available to the
pemon .applying the prsllclde, unless
the Agency has determined that the
pesticide may only be appll-d under
the direct supervision of a certified ap-
plicator who Is physically prne.nl.
(P) Other pertinent Information
which the Administrator d< terrnlnes
to be necessary lor the protection of
man and the environment.
of this sec-
tion. Any pesticide product for Which
some uses are classified for general use
and others for restricted use shall be
separately labeled according to the la-
beling standards set forth In this sub-
section, and shall be marketed as sepa-
rate products with different registra-
tion numbers, one bearing directions
only for general uie and thr other
bearing directions for restricted u*eX*>
except that. If a product has both re-
stricted use(s) and general use<8>. both
of these uses may appear on a product
labeled for restricted use. Such prod-
ucts shall be subject to the provisions
of | 192 I(MJM2>.
< I) General Uie C7 of the Act.
Intent to cancel rests trail)
to section )t(bMI> of
notice of InlVit to hoi
determine
should be cancelled
proprlate. shall
termination by ...
the pesticide mee
the criteria for
graph of trils
determination/ the
•hall Uaue notice by
fle prr-
bllr* of
mant to
' notice of
pursuant
Art. or
hearing to
registration
denied, an ap-
, lued. upon a de-
idmlnlslrmlor that
or exceeds any of
•I forth In para-
tlon. Upon such
Administrator
Ifled mall to
the appllcan/or rrgtalralat. as thr e**e
may be. staling that the\*ppllr*nt or
registrant/ha* the opportunity to
•ubmlt evidence In rebuUAJ of such
presumnlon In accordance win para-
grmph/KHO of this section. TVe appli-
cant ft registrant shall have forty-five
(48>yAayi front the date such notice la
•eni to submit evidence In rebutwl of
trye presumption; provided. hnwAwer.
tat for good cause shown the Arlmf
fstrator may grant an additional sl»
-------
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-------
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IO
P»I»S<:AI on
ni
STORAGE AND
DISPOSAL
SlonAut • -
coo*1 —
R(:STRICTED USE
PESTICIDE
For r«l|tt »,l. U mtf utt
• r fcrioni u'>lf t*>«lr rfl'I
lhait «iti cu.rrc4 bf Iht (
otltn. .
«ppllci(ori
0"lr far
*|.|llc«lori (trllll-
PRODUCT
NAME
> ia'IU(HI IK)
Nil
owe
cnor
3>
S>
©
awe
-------
Criteria
PHYS/CHEM-1
PHYSICAL/CHEMICAL HAZARDS
Required Label Statement
I. Pressurized Containers
A. Flashpoint at or below
20°F; or if there is a
flashback at any valve
opening .
Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is .more than 18 inches
long at a distan.ce of
6 inches from the
valve opening .
All Other Pressurized
Containers
Men-Pressurized Containers
A. Flashpoint at or below
20°F.
B. Flashpoint above 20°F
and not over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Extremely flammable.
Contents under pressure .
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame- Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces .
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
-------
STOR-1.
STORAGE INSTRUCTIONS FOR PESTICIDES
Heading:
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions .
must -be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL."
Storage Instructions:
All product labels are required to' have appropriate storage
instructions. Specific storage instructions are not prescribed.
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
•1 . Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes,, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
1. Specifications for handling the pesticide container,
including movement ot container within the storage area,
prccer openir.c and closing procedures (particularly for
cpar.ec ccnca-r.ars; , inc. .measures co m i n im i ~ e exposure
while opening or closing container.
4. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
-------
140
PEST/DIS-1
PESTICIDE DISPOSAL INSTRUCTIONS
The label of all products, except those intended solely for domestic
use, must bear explicit instructions about pesticide disposal. The
statements listed below contain the exact wording that must appear' on
the label of these products:
1. The labels of all products, except domestic, use, must contain the
statement, irCo not contaminate water, food, or .feed by storage or disposal."
2. Except those prcducts intended solely for domestic use, the. labels
of all products that contain active ingredients that are Acute Hazardous
Wastes (see list in this Appendix) or are assigned to Toxicity Category
I on the basis of oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhalation toxicity
must bear the following pesticide disposal statement:
"Pesticide wastes are acutely hazardous. Improper disposal of
excess pesticide, spray mixture, or rinsate is a violation of Federal
Law. If these wastes cannot be disposed of by use according to
label instructions, contact your State Pesticide or Environmental
Control Agency, or the Hazardous Waste representative at the nearest
EPA Regional Office for guidance.!'
3. The' labels of all products, except those intended for domestic use,
containing-active or inert ingredients that are Toxic Hazardous Wastes.
(see list in this. Appendix) or meet any of che criteria in 40 CFR 261,
Subpart. C for" a hazardous, waste must bear the following pesticide disposal
statement:
"Pesticide wastes sre toxic. Improper disposal of excess pesticide,
sprav -ixnure, rr rir.sat-e .3 i 'loiacicn cf Federal Law. :f -.nese
wastes cannot be disposed of by use according to laoei instructions,
contact your State Pesticide or Environmental Control Agency, or the
Hazardous Waste representative at the nearest EPA Regional Office
for guidance."
4. Labels for all other products, except those intended for domestic
use, must bear the following pesticide disposal statement:
"Vfestes resulting from the use of this product may be disposed of on
site or at an approved waste disposal facility."
5. Prcducts intended for domestic use only must bear the following
disposal statement: "Securely wrap original container in several layers
of newspaper and discard in trash,"
-------
14! ••
PEST/DIS-2
PESTICIDE ACTIVE INGREDIENTS THAT ARE ACUTE HAZARDOUS WASTES
I. PESTICIDES ON- THE lrE" LIST
[40. CFR 261.33(8} J
with RCRA f and CAS
Ac role in
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine (Avitrol)
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroan.iline
Cyanides (soluble cyanide salts
not otherwise specified)
Cyanogen chloride
Dieldrin
0,0-Diethyl S-[2-ethyithio)ethyl]
phosphorodithioate (disulfoton)
0,0-Diethyl 0-pyrazinyl
phosphorocnioace (Zinophos*)
Dimethoate
0,0-Dimethyl 0-p-nitrophenyl
phosphorothioace ^iiecnyl parachion)
4,6-Dini'tro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
Dinoseb
"p.dosul fan
Endrin
Famphur
Fluoroacetamide
Heptachlor
Hexachlorohexahydro-exo
d imethanonaphthalene
'Hydrocyanic acid
Methorny1
alpha-Naphthylthiourea
Nicotine and salts
Octamethylpyrophosphor amide
(OMPA, schradan)
Pa rathion
Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacecace
exo-
(Isodrin
;ANTU;
P003
P070
POO 4
POOS
P006
POOS
P010
P011
P012
P021
P022
P024
P030
P031
P037
P039
107-13-1
116-06-3
309-00-2
107-18-6
1302-45-0
504-24-5
7778-39-4
1303-28-2
' 1327-53-3
592-01-8
75-15-0
106-47-8
506-77-4
60-57-1
298-04-4
P040
297-97-2
P044
P071
P047
P034
P020
P050
?033
P051
P097
P057
P059
P069
P063
P066
P072
P075 -
P085
P089
P092
P094
P098
P102
P105
P106
P058
60-51-5
298-00-0
534-52-1
131-89-5
88-85-7
115-29-7
129-67-9
72-20-8
52-85-7
640-19-7
76-48-8
465-73-6
74-90-8
"16752-77-5
86-88-41
54-11-5
152-16-9
56-38-2
62-38-4
298-02-2
151-50-3
107-19-7
26628-22-8
143-33-9
62-74-3
-------
L42
PEST/DIS-3
Strychnine and salts. P108
0,0,0,0-Tetraethyl P109
.dithiopyrophosphate (sulfotepp)
Tetraethyl- pyrophosphate Pill
Thall-ium sulfate P115
Thiofanox P045
Toxaphene P123
Warfarin (>0.3%) P001
Zinc phosphide (>10%) P122
57-24-9
60-41-3
3689-24-5
107-49-3
7446-18-6
39196-18-4
8001-35-2
81-81-2
1314-84-7
•50 ACTIVES
II. PESTICIDES DERIVED FROM TRI-, TETRA-, AND PENTACHLOROPHENOLS
[40 CFR 261.31]
2-Chloroethyl 2-(2,4,6-trichloro-
phenoxy) ethyl ether
Dehydroabietylammonium
pentachlorophenoxide
Erbon
0-ethyl 0-(2,4,5-trichloropnenyl)
ethylphosphonothioate
2,2 ' -Methylenebis
(3,4,6-trichlorophenol)
(Hexach'Iarophene)
—Potassium salt of
—Sodium salt of
--Di sodium sal1: :f
Pentachlorophenol
--Potassium salt of
—Sodium salt of,
— Zinc salt of
— Zinc salt of N-alkyl
(CI^-CIQ)-!r3-propanediamine
—Pentachlorophenyl laurate
trichlorophenate
trichloroohenate
2,4,6
2,4,5
Potass ium
Potassium
5 ilvex
—2-Butoxyethyl ester
—Butoxypolypropoxypropyl ester
—Butoxypropyl ester
—Diecnanolamine sale
•—Diisopropanolamine salt
—Dimethylamine salt
—Dipropylene glycol isobutyl
ether ester
--Ethanolamine salt
--2-Ethylhexyl ester
--Isooctyl ester
F027 5324-22-1
F027 35109-57-0
F027 136-25-4
F027 327-98-0
F027 70^30-4
F027 67923-62-0
F027 3247-34-5
F027 5736-15-2
F027 87-86-5
F027 7778-73-6
F027 131-52-2
F027 2917-32-0
F027
F027 -3772-94-9
F027 2591-21-1
F027 35471-43-3
F027 93-72-1
F027 19398-13-1
F027 53404-07-2
F027 25537-26-2
F027 51170-59-3
F027 53404-09-4
F027 55617-85-1
F027 53535-26-5
F027 7374-47-2
F027 53404-76-5
F027 53404-14-1
-------
143
PEST/DIS-4
— Isopropanolanvine salt
—Monohydrox-ylaluminum salt
—Polypropoxypropyl ester
—Potassium salt •
-r-Propylene glycol isobutyl
ether ester
—Sodium salt
—Triethanolamine salt
—Triethylamine salt
—Triisopropanolamine salt
—Tripropylene glycol isobutyl
ether ester
Sodium 2-(2,4,5-trichlorophenoxy)
ethyl sulfate
Tetrachlorophenols'
—Alkylamine*amine salt (as in
fatty acids of coconut oil)
—Potassium salt
—Sodium salt
2,4,5-Trichlorophenol
2,4,6-Trichlorophenol
2,4,5-Trichlorophenol salt of
2,6-bis[(dimethyl amino)methyl]
cyclohexanone
2,4,5-Trichlorophenol, sodium salt
2,4,6-Trichlorophenol, sodium salt
o d ^ „
Alkyl C-13 amine salt
Alkyl C-14 amine salt
N,N-diethylethanolamine salt
Dimethylamine salt
N,N-dimethyllinoleylamine salt
N,N-dimethyloleylamine salt
N-oleyl-1,3-propylene
diamine salt
Sodium salt
Triethanolamine salt
Triethylamine salt
Alkyl (C3H7 - C7H9) ester
Amyl ester
Butoxyethoxypropyl ester
2-5ucoxyethyl ester
Butoxypropyl ester
Butyl ester
Dipropylene glycol isobutyl
ether sster
2-Ethylhexyl ester
Iscbutyl ester
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
?027
F-027
F027
F027
F027
F027
53404-13-0
69622-82-8
83562-66-7
2818-16-8
53466-84-5
37913-89-6
17369-89-0
53404-74-3
53404-75-4
53535-30-1
3570-61-4
25167-83-3
53535-27-6
25567-55-9
95-95-4
88-0.6-2
53404-83-4
136-32-3
3784-03-0
93-79-3
52404-04-5
53404-85-6
53535-37-8
53404-86-7
6369-97-7
53404-88-9
53404-89-0
53404-87-8
13560-99-1
3813-14-7
2008-46-0
120-39-8
1928-58-1
?545— 3°— 7
1928-48-9
93-79-8
53535-31-2
1928-47-8
4938-72-1
-------
144
PEST/DIS-5
—Isopropyl ester F027 93-73-7
—Propylene glycol isobutyl F027 53466-86-7
ether este-r
—Tripropylene glycol isobutyl F027 53535-32-3
ether ester
4-(2,4,5-Trichlorophenoxy)butyric F027 93-80-1
acid [2,4,5-TB]
2-(2,4, 5-Trichlorophenoxy) ethyl F027 69633-04-1
hydrogen sulfate [2,4,5-TES]
1,4',5'-Trichloro-2'-(2,4,5- F027 69462-14-2
trichlorophenoxy)
methanesulfonanilide [Edolan U]
-------
PEST/DIS-6
PESTICIDES THAT ARE TOXIC HAZARDOUS WASTES-
PESTICIDES ON THE "F" LIST
[40 CFR 261.331f)J
(with RCRA fry and CAS
Acetone
Acrylonitrile*
Amitrole
Benzene*
Bis( 2-e thy IhexyDph thai ate
Cacodylic acid
Carbon tetrachloride*
Chloral (hydrate)
(chloroacetaldehyde)
Chlordane, technical*
Chlorobenzene*
4-Chloro-m-cresol
Chloroform*
o-Chlorophenol
Creosote
Cresylic acid (cresols)*
Cyclohexane
Cyclohexanone
Dec-achlorooctahydro-1, 3 , 4-metheno-
3[c,d]-pentalen-2-one
TU.
(Keponev ch-iordecone)
1,2-Dibromo-3-chioropropane (DBCP)
Dibucyl' ghthaiate
S-2,3-(Drchloroallyl diisopropyl-
thiocarbamate) (diallate,Avadex)
o-Dichlorobenzene*
p-Dichlorobenzene*
(Freon 12*)
3,5-Dichloro-N-(1,1-dimethy1-2-
propynyl) benzamide
(pronamide, Kerb®)
Dichloro diphenyl dichloroethane
(ODD)
Dichloro diphenyl trichloroethane
(DDT)
Dichloroethyl ether
2,4-Dichlorophenoxyacetic,
salts and esters (2,4-D)*
1,2-Dichloropropane
1,3-Dichloropropene (Telone)
Dimethyl phthalate
Epichlorohydrin
(l-cnioro-2 , 5-e poxy-pro pane)
Ethyl acetate
Ethyl 4 , 4'-dichlorobenzilate
(chlorobenzilate)
U002
U009
U011
U019
U028
U136
U211
U034
U036
U037
U039
U044
U048
U051
U052
U056
U057
U142
67-64-1
107-13-1
61-82-5
71-43-2
117-81-7
75-60-5
56-23-5
302-17-0
57-74-9
108-90-7
59-50-7
67-66-3
95-57-8
8021-39-4
1319-77-3
110-82-7
108-94-1
143-50-0
U066
U069
U062
U070
U072
"JO"' 5
96-12-8
84-74-2
2303-16-4
95-50-1
106-46-7
75-71-3
U192
U060
U061
U025
U240
U083
U084
U102
U041
U112
U038
23950-58-5
72-54-8
50-29-3 •
1191-17-9
94-75-7
8003-19-8
542-75-6
131-11-3
106-89-8
141-78-6
510-15-6
*Propos'ed for deletion by TCLP proposal
-------
146.
PEST/DIS-7
Ethylene dibromide (EDB)
Ethylene dichloride*
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene*
Hexachlorocyclopentadiene
Hexachioroe thane*
Hydrofluoric acid
Isobutyl alcohol*
Lead acetate
Lindane*
Maleic hydrazide
Mercury
Methoxychlor*
Methyl alcohol (methanol)
Methyl bromide
Methyl chloride
2,2' -Methylenebis
(3,4,6-trichlorophenol)
(hexachlorophene)
[acute waste per 261.31]
Methylene chloride*
Methyl ethyl ketone*
4-Me.thyl-2-pentanone
(methyl. isobutyL ketone)
Naphthalene
Nitrobenzene*
p-Nitrophenal
Pen tachlo.roe thane
Pentachloronitrobenzene (PCNB^
[acuce wasce per ^51.5Ij
Phenol*
Pyridine*
Resorcinol
Safrole
Selenium disulfide
Silvex [acute waste per 261.31]
T, 1,2,2-Tetrachloroethane*
Tetrachloroethylene*
2,3,4,6-Tetrachlorophenol*
[acute waste per 251.31]
Thiram
Toluene*
1,1,1-Trichioroe thane*
(methyl chloroform)
Trichloroethylene*
Trichloromonofluoromethane
. (Freon 11*)
2,4,5-Trichlorophenol*
[acuce waste per- 251.31]
2,4,6-Trichlorophenol*
[acute waste per 251.31]
U067
U077
U115
U122-
U125
U127
U130
U131
U134
U140
U144
U129
U148
U151
U247
U154.
U029
U045
U132
106-93-4
107-06-2
75-21-8
50-00-0
98-01-1
118-74-1
77-47-4
67-72-1
7664-39-3
78-83-1
301-04-2
58-89-9
123-33-1
7439-97-6
72-43-5
67-56-1
74-83-9
74-87-3
70-30-4
U080
U159
U161
U165
(J169
U170
U184
U185
'J 2 4 2
U188
U196
U201
U203
U205
U233
U209
U210
U212
U244
U220
U226
U228
U121
U230
U231
75-09-2
78-93-3
108-LO-l
91-20-3
98-95-3
100-02-7
76-01-7
82-68-8
3^-36-5
108-95-2
110-86-1
108-46-3
94-59-7
7488-56-4
93-72-1
79-34-5
127-18-4
137-26-8
108-88-3
71-55-6
79-01-6
75-69-4
95-95-4
88-06-2
-------
147
PEST/DIS-8
2,4r.5—Trichlorophenoxyacetic acid • U232
(2,4,5-T)*
[acute waste- per 261.31]
Warfarin (<0-3%) U248
Xylene U239
Zinc phosphide (<10%) U249
93-76-5
81-81-2
1330-20-7
1314-84-7
83 ACTIVES
-------
148
CONT/DIS-1
CONTAINER DISPOSAL INSTRUCTIONS
The label of each product must bear container disposal
instructions appropriate to the type ot container.
1- Domestic use products must bear one of the following
container disposal statements:
Container Type
Statement
Non-aerosol products
(bottles, cans, jars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, jar) .
Rinse thoroughly before discarding in trash.
•Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
2. All other products must bear container disposal
based on container type, listed below:
instructions
Container Type
Statement
Metal
containers
(non-aerosol
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
ocner procedures approved by state and local
authorities .
Plastic- containers
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning. IE burned,
stav out of smoke.
:u_ valenc
.hen
Fiber drums
with liners
Paper and
plastic bags
Compressed gas
cylinders
of in a sanitary landfill or oy ocner
approved state and local procedures.
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by_ incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused1, dispose of in the same manner.
Completely empty- bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Return empty cylinder for reuse (or
similar wording)
I/ Manufacturer may replace this phrase with one
~~ whether and how fiber drum may be reused.
indicating
-------
EPA Compendium of Acceptable Uses
0,0-DTHETHTL S-( ( 4-0X0-1 f2f 3-BENZOTRLAZIN-3( 4H)-TL)-
METHYL) PHOSPHORODITHIOATE
TABLE OF CONTENTS
Site Name
TERRESTRIAL FOOD CROPS
(Agricultural Crops)
Alfalfa
Alfalfa-Grass Mixture
Almond
Apple
Apricot
Artichokes
Barley
Beans, Dry
Beans, Dry (seed crop)
Beans, Snap
Birdsfoot Trefoil
Blackberry
Blueberry
Boysenberry
Broccoli
'Brussels Sprouts
Cabbage
_.?.uli flower
Celery
Therry
Citrus -Fruits
Clover
Clover-Grass Mixture
Cotton
Cranoerry
Cucumber
Zggplanc
Filbert
Grapes
Loganberry
Melons
Nectarine
Oats
Onions, Dry
Onions, Green
Pasture Grasses
Peach
Pear
Peas, Field
Pecan
Pepper
Pistachio "uts
Plum
Potato
Prune
Page
3
3
3
3
4
. 5
6
8
9
9
10
10
10
11
12
11
13
13
13 .
13
15
15
16
3
3
18
:i
21
21
22
22
11.
23
6
9
^ /
24
24
A f
25
6
5
O C
25
26
26
27
27
28
27
Issued: 2-23-35 111-058001-1
-------
150
EPA. Compendium- of Acceptable-.- Uses
o, Q-DIM;THYL s-( (4-oxo-i, 2, S-BENZOTRIAZm-3(4H) -YL) -
METHYL) PHOSP.HORODITHIOATE
TABLEOE CONTENTS
Site Name __^_ Page
Quince • • 5
Raspberry 11
Rye . 9
Safflower (seed crop) ' 29
Soybeans 30
Spinach 31
Strawberry 31
Sugarcane 32
Tomato 32
Vetch (seed crop) 35
Walnuts 35
Wheat 9
TERR-ESTRIAL NON-FOOD CROP 36
(Agricultural Crops) 36
Tobacco 36
(Ornamental Plants and Forest Trees) 36
Ornamental Plants (including shade trees and nursery stock) 36
FORESTRY 39
Forest Trees , 39
Pine Plantations ' 39
Slash Pine (seed orchards) • 39
Southern' Pine (seed orchards) 39
Issued: 2-28-85 III-053001-ii
-------
151
EPA Compendium- of Acceptable Uses"
0,0-DIMETHYL S-((4-0X0-1,2,3-BENZOTRIAZIN-3(4H)-YL)-
METHYL) PHOSPHOROD.ITHIOATE*
TYPE PESTICIDE; Insecticide, Acaricide-, Molluscicide
FORMULATIONS;
Tech (85%, 94Z)
FI (1 Ib/gal, 21%, 22%, 25%)
D (2%, 2.5%, 3%, 6%)
G (5%, 7%, 10%)
WP (25%, 50%, 62.5%)
EC (0.25 Ib/gal, 0.75 Ib/gal, 1 Ib/gal, 1.5 Ib/gal, 2 Ib/gal, 5%>
12.37%)
FIG (2 Ib/gal, 3 Ib/gal)
SC/L (12.4%)
GENERAL WARNINGS AND LIMITATIONS: All liquid formulations with a concen- '
cration greater than 13.5 percent are RESTRICTED USE PESTICIDES. Unpro-
tected persons and beneficial animals should be kept out of the treated
area and ouc of the vicinity where there .may be danger of drift. Treated
areas should not he re-entered for at least 24 hours unless protective
clothing is worn. Do not feed treated crop trash to livestock except
where specified. For additional protective information consult your State
Cooperative Agricultural Extension Service. For granular formulations,
cover or incorporate granules that are spilled during loading or are visi-
ble on soil surface in turn areas. Do not use wettable powder water
soluble- pouches for mailing highly concentrated aixtures unless they are
premixed in;, nurse tanks with adequate agitation. When using ho.se-end pro-
portioners do not spray trees or shrubs above 5 feet. The use'of undilut-
ed sprays nay cause spotting of automobile finishes if prolonged exposure
is permitted.''Do not spray directly over automobiles. Automobiles touch-
ed by spray should be washed immediately. Refer to labeling for appropri-
ate Endangered Species Restrictions..
Protective Clothing: HANDLE THE CONCENTRATE ONLY WHEN WEARING THE FOLLOW-
Wear a protective suit of one or two pieces that covers all parts of the
body except che head, hands and feet. Wear chemical resistant gloves,
chemical resistant apron and chemical resistant shoes, shoe coverings or
boots. Wear goggles or a face shield. Wear a pesticide respirator ap-
proved by the National Institute for Occupational Safety and Health under
the provisions of 30 CFR Part II.
FOR LIQUID FORMULATIONS, the following labeling is required:
If handling the concentrate with a closed system, long sleeved shirt and
long pants may be substituted for the protective suit and the respirator
requirement is waived.
WEAR THE FOLLOWING PROTECTIVE CLOTHING DURING APPLICATION, EQUIPMENT RE-
PAIR, EQUIPMENT CLEANING, DURING EARLY RE-ENTRY TO TREATED AREAS AND DIS-
POSAL OF THE PESTICIDE:
Wear a protective suit of one or two pieces that cover all parts of the
body except che head, hands, and feet. Wear chemical resistant gloves and
chemical resistant shoes, shoe coverings or boots.
*Guthion
Azinphos-methyl
Issued: 2-23-35 III-058001-1
Provisional Update: 3-25-86
-------
:152
EPA Compendium of Acceptable Uses
0,0-DIHETHYL S-( ( 4-0X0-1 ,.2, 3-BENZOTRIAZ:DI-3( 4H)-YL)-
METHYL) PROSPHORODITHIOATE
GENERAL WARNINGS- AND LIMITATIONS (continued)
During application only from a tractor with a completely enclosed cab or
aerially with an enclosed cockpit, long sleeve shirt and long pants may
be worn in place of the above protective clothing. Chemical resistant
gloves must be available in the cab or cockpit and must be worn while
exiting. This clothing is inadequate to protect you during equipment re-
pair, equipment cleaning, re-entry, or during pesticide disposal.
-.grlcultural Crop Tolerances (other than those listed in the text) :
5 ppm Gooseberries
10 ppm Kiwi fruit
5 ppm Parsley, leaves
2 ppm Parsley, roots
livestock Tolerance:
,\1 ppm Meat, fat, and meat byproducts of cattle, goats,
horses, and sheep
Bee Caution:
"uthionr is toxic to bees exposed to direct treatment or residues on crops,
ind should not be applied when bees are actively visiting the areas.
••:•:'inition of Terms:
psi - pounds per square inch
I - multiple active ingredient(3)
7i~lespopns/teaspoons actual. A hypothetical quantity computed by multi-
~ ving the number (or equivalent number) of .tablespoons/teaspoons of
;c'aucc by Che concentration of guthion in the formulation.
** Exact.'computation of actual dosage is not possible because of the lack
veight/volume, information on the label. Extrapolation from other
;: filiations reveals that the dosage from this label appears to fall
•-- •_•.'.n the range shown by formulations with known weight/volume ratios.
Issued: 2-23-85 III-058001-2
-------
153.
EPA Compendium of Acceptable Uses
0,0-DIMETHYL .S-< ( 4-0X0-1, 2, 3-BENZOTRIAZIN-3( 4H)-YL) -
METHTL) PHQSPHORODITHIOATE
Site- and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
TERRESTRIAL FOOD CROPS'
(Agricultural Crops)
General Warnings and Limitations L Root crops may be planted 180 days
after the last application. All other crops (other than those provided
for in CFR 40 180.154) must not be planted within 30 days of last appli-
cation. Apply wettable powders in sufficient water for thorough cover-
age by aircraft or ground equipment with the exception of formulations
In water soluble packets which are not suited for aircraft applications.
Apply emulsifiable concentrate and flowable concentrate formulations in
i ini r.''cnun of 1 gallon per acre by aircraft or ground equipment unless
rytsi specified.
L' g?,lfa
Alfalfa-Grass Mixture
•'i'--3rass Mixture
Alfalfa plant bug
Aphids
"leahoppers
Leaf hoppers
Lygus bugs
Mices
0.45-0.75
Ib/A
• ^«» -,«» -^ \
V >L-» , jn ^
or
abugs
2 ppm (alfalfa, clover, grass pas-
ture (green))
5 ppm (alfalfa hay, clover hay,
grass pasture hay)
14 day preharvest/pregrazing inter-
val through 0.375 pound per acre for
foliar application.
16 day preharvest/pregrazing inter-
val through 0.5 pound per acre for
foliar application.
21 day preharvest/pregrazing inter-
val through 0.75 pound per acre for
foliar application.
Do -ot sake sore ~han 1 aopllcation
per cutting rhrough 0.75 pound per
acre.
Do not make more than 2 applications
per cutting through 0.25 pound per
acre. Applications to mixed stands
of alfalfa-grass or clover-grass are
limited to states East of the Mis-
sissippi River. Unless otherwise
specified apply dosages in a minimum
of 1 gallon of water per acre by
aircraft and 10 gallons of water per
acre by ground equipment.
Foliar application. May be applied
by aircraft. Apply when pest first
appears and repeat as needed. '-Then
making 2 applications per cutting
recheck fields 10 Co 11 days after
Che first for proper timing of che
second. For alfalfa weevil in heavy
growth, apply in a minimum of 5 gal-
2-:3-85
III-058001-3
-------
154
EPA Compendium- of Acceptable Uses
0,0-DIMETHYL S-( ( 4-0X0-1, 2, 3-BENZOT3.IAZIN-3( 4E)-TL)-
METHYL) PHOSPHORODITHIOATE
Site and Pest
Dosages arid Tolerance, Use, Limitations
Fonnulation(s)
Alfalfa cluster (continued)
.Mf-vfa weevil
Egyptian alfalfa
0.5-0.75 Ib/A ions Of water per acre by aircraft
(25%, 50% WP) and in 20 to 25 gallons of water
(1.5, 2 lb/ per acre by ground equipment.
gal EC)
(2, 3 Ib/gal
F1C)
0.25-0.75
Ib/A
(25%, 50% WP)
(1.5, 2 lb/
gal EC)
(2, 3 Ib/gal
FIG)
Lea;noppers
?- .;.'.-. tvig borer
0.25-0.5 Ib/A
(25%, 50% WP)
(1.5, 2 lb/
gal EC)
(2, 3 Ib/gal
F1C)
0.5-0.75 Ib/A
(25%, 50% WP)
(1.5, 2 lb/
gal EC)
F1C)
0.3 ppm (almonds)
10.0 ppm (almond hulls)
60 day preharvest interval through
2.5 pounds per acre for foliar ap-
plication.
Do not make more than 2 applications
per fruit year. Do not graze live-
stock in treated orchards or groves
for 21 days after treatment.
0.375-0.5 lb/ Foliar application. Allow a minimum
100 gal of. 30 days between applications.
[max. 500
gal/A]
(50% WP)
(2 Ib/gal EC)
Issued: 2-23-85
111-053001-4
-------
EPA Compendium of. Acceptable.. Uses
0>0-DIMETHYL S-( ( 4-0X0-1, 2, 3-BENZOTRIAZCI-3( 4E)-YL)-
METHy.L) PHOSPHORODITHIQATE
Site and. Pest
Dosages and Tolerance,. Use, Limitations
Formulatlon(s)
Apple
Crabapple
Pear
Quince
2 ppm
7 day preharvest interval through
2.5 pounds per acre for 6 foliar ap-
plications followed by 2'pounds per
acre for 2 foliar applications.
15 day preharvest interval through
3.125 pounds per acre for 8 foliar
applications.
7 day preharvest interval through
1.5 pounds per acre for 3 foliar ap-
plications or 1 pound per acre for
5 foliar applications when applied
by aircraft.
The sprayable formulations are com-
patible with dormant and summer oils
which may be added to apple and pear
sprays in accordance with State Co-
operative Agricultural Extension
Service recommendations.
Do not graze livestock in treated
.orchards or groves for 21 days after
treatment.
maggot
. .
£ .:ropean apple
Forbes scale
Fruittree leaf-
roller
Green fruitworm
Leafhoppers
Mealybugs
Mites
Orange tortrix
Plum curculio
Putnam scale
'Redbanded leaf-
roller
"_-i Jose scale
Stink bugs
Tarnished olanc
0.75-1.1 Ib/A Foliar application. May be applied
(2.5£, 3Z, 6% by aircraft. Apply when pest first
D) appears and repeat at 7 to 10 day
or intervals as needed.
0.48-0.96 oz/ May be formulated with zineb, fer-
or :a
(3% D)
0.25-0.313
lb/100 gal
water
[max. 1,000
gal/A]
Foliar applications at 0.25 co 0.313
pound per 100 gallons of water fol-
lowed by 2 applications at 0.25
pound per 100 gallons of water. Ap-
ply at petal fall stage and repeat
(25%, 50% WP) at 10 to 14 day intervals until con-
(2 Ib/gal EC) trol is achieved.
1-1.5 Ib/A Foliar application. Apply by air-
(50% WP) craft. Apply specified dosage in a
minimum of 3 gallons of water per
acre for the Northwestern United
States and in a minimum of 10 gal-
lons of water per acre for other
areas. Where aphids and mites are
a problem aerial applications may
not provide satisfactory control.
>2S-85
111-058001-5
-------
EPA. Compendium of Acceptable- iJsea-
0,0-DIKETHrL S-( ( 4-0X0-1, 2, 3-BENZOTRIAZDT-3( 4H)-':
METHTL) PHOSPHORODITHIOATE
Sice and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
Apple cluster (continued)
0.042 oz/gal Foliar application.
(1 Ib/gal EC)
or
2-3 tbls 5Z
EC/gal
(5% EC)
or
1 tbls 12.4%
SC/L/gal
(12.4% SC/L)
(Apple)
(Crabapple)
(Quince)
Apple maggot
Codling moth
European apple
sawfly
£yespotted bud aoth
Fruittree leaf-
roller
Green fruitvora
Orange tortrix
Plum curculio
Redbanded leaf-
roller
0.5-1 Ib/A ULTRA LOW VOLUME. Foliar applica-
(2 Ib/gal EC) tion.
Use limited to ID, OR, WA, and UT.
Apply undiluted by helicopter or
fixed wing aircraft.using Becomist
nozzles with 20 micron sleeves.
Nectarine
-'each
2 pptn
21 day preharvest interval through
2.5 pounds per acre for foliar ap-
plication.
Do not make more than 8 applications
per fruiting season. The sprayable
formulations are compatible with
dormant and summer oils which may
be added to peach sprays in accor-
dance with State Cooperative Agri-
cultural Extension Service recommen-
dations. When treating nectarines
during bloom period, beekeepers
should be warned well in advance to
remove hives a safe distance from
orchards to be treated. Do. not
graze livestock in treated orchards
or groves for 21 days after treat-
ment .
Issued: 2-23-85
III-058001-6
-------
EPA- Compendium:- of- Acceptable; Uses-
0,0-DTMETHYL S-< (4-0X0-1, 2, 3-SENZOTRIAZIN-3( 4H)-TL)-
METHYL) PHOSPHORODITHIOATE
3A
;A
?A
IA
AA
3A
'JA
I1 A
AA
_3A
.QA
3 A
BA
Site and Past
Dosages and Tolerance, Use, Limitations
Formulation(s)
Apricot cluster (continued)
0.25-0.313
Ib/lCTO gal
[max. 800
gal/A]
(25%, 50% WP)
(2 Ib/gal EC)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 cbls 57
EC/gal
(5% EC)
or
1 tbls 12.4%
SC/L/gal
(12.4% SC/L)
Foliar application. Apply when pest
first appears and repeat as needed.
For scales, apply when crawlers are
present.
Aphids
Cottony peach scale
European fruit
lecanlum
Forbes scale
Lesser peachtree
borer
Mites
Plum curculio
Redbanded leaf-
roller
Jan Jose scale
Stink bugs
Tarnished plant bug
Terrapin scale
rhrips (on necta-
rines)
Variegated leaf-
roller
'Valnut scale
//hits peach scale
\phids--" • 1.05-2.4 Ib/A Foliar application. May be applied
Mices (3% D) by aircraft. Apply when pest first
Oriental fruit moth or appears and repeat as needed.
Peach twig borer 0.042 oz/gal May be formulated with ferbam or
'
roller
Variegated leaf
roller
or
2-3 tbls 5%
EC/gal
(5% EC)
or
1 tbls 12.4%
SC/L/gal
(12.4% SC/L)
borer
B^rk application. Apply 2 to 3
gal sprays to trunk between ground and
(25%, 50% WP) scaffold limbs,, timed with moth
(2 Ib/gal EC) flight.
or
0.042 oz/gal
(1 Ib/gal EC)
or
Issued: 2-23-35
II1-058001-7
-------
EPA Compendium, of Acceptable Use-s
0,0-DIMETHYL S-« 4-0X0-1, 2, 3-3ENZOTRLAZIN-3(4H)-YL)-
METHTL) PHOSPHORODITHIOATE
Site and Pest
Dosages- and Tolerance, Use, Limitations
Fommlation(s)
Apricot cluster (continued)
2-3 tbls 5Z
EC/gal
(5% EC)
or
1 tbls 12.42
SC/L/gal
(12.4% SC/L)
C rental fruit moth 0.25-0.375 Foliar application. Apply the high.
"-: . .- twig borer lb/100 gal dosage before mid-season.
[max. 800/A]
(25%, 50% WP)
(2 Ib/gal EC)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 5%
EC/gal
(5% EC)
or
1 tbls 12.4'
• - SC/L/gal
(12.4% SC/L)
2 pom
20 -av •: rsharvest interval through
1.5 pounds per acre for foliar ap-
plication.
Do not ensile or feed treated for-
age.
Plurae moths
1.5 Ib/A Foliar application. Repeat as need-
(25%, 50% WP) ed.
(2 Ib/gal EC)
or
2 tbls 5%
EC/gal
(5% EC)
Issued: 2-28-85.
III-058001-8
-------
LAA
3AA
5AA
7AA
EPA 'Compendium- of- Acceptable- Uses-
0,.0-DTHETHYL S-< (4-0X0-1, 2,1-BENZOTRIAZIN-3(4E)-YL)-
METHYL) PHOSPHORODITHIOATZ
Site and Pest
Barley
Cereal leaf beetle
Dosages and. Tolerance, Use, Limitations'
Formulation(s)
0.2 ppm (barley, oat, rye, wheat
grain)
2.0 ppm (barley, oat, rye, wheat
straw)
30 day preharvest/pregrazing inter-
val through 0.5 pound per acre for
•foliar application.
Do not make more than 1 application
per growing season.
0.375-0.5
Ib/A
(25%, 50% WP)
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
Foliar application.
1AA
3AA
Beans, Dry
.AA
JIA
,GA
JLA
.BA
LAA
vTA
'-.JA
3 MA
3MA
ATA
Aphids
Bean leaf beetle
Oraen tiovervom
Leafminers
Leaf rollers
Mites
Stink bugs
Velvetbean cater-
pillar
0.3 ppm
30 day preharvest interval through
0.6 pound per acre for foliar appli-
cation.
Do not make more than 4 applications
per growing season. Do not ensile
or feed treated forage.
0.44-0.6 Ib/A Foliar application. May be applied
(2%, 3% D) by aircraft. Apply when pest first
or appears and repeat as needed.
-'--3-0. ; Ib/A May TS forauiatea vich sulfur.
(257., 507. WP)
(2 Ib/gal EC)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 5%
EC/gal
(5% EC)
or
3 tsp 12.4%
SC/L/gal
(12.4% SC/L)
Mexican bean beetle 0.5-0,6 ^b
Spotted cucumber (2%, 3% D)
beetle or
Striped cucumber
beetle
Tarnished plant bug
Issued: 2-23-35
III-058001-9
-------
of Acceptable- Uses
0, 0-DUiZTHTL S-( ( 4-0X0-1, 2, 3-BENZOTRlAZIN-3( 4H) -YL) -
METHYL) PHOSPHORODITHIOATE
Site and Pgst Dosages and Tolerance, Use, Limitations
Formulation( 3)
Beans, DTT (continued)
Pest list continued from previous- page.
Western striped Q.5 Ib/A
cucumber beetle (252, 50% WP)
(2 Ib/gal EC)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 57,
EC/gal
(5% EC)
or
3 tsp 12.4%
SC/L/gal
(12.4% SC/L)
Beans, Dry (seed crop) . N.F.
Do not ensile or feed treated for-
age.
Mexican bean beetle 0.5-0.75 Ib/A Foliar application to seed crop.
(25%, 50% WP) Repeat as needed.
Beans, Snap 2 ppm
7 day preharvest interval through
0.5 pound per acre for foliar appli-
Do not ensile or feed treated for-
age .
Refer to Beans, Dry for pest, use and limitation
information.
Birdsfoot Trefoil 2 ppm (birdsfoot trefoil)
5 ppm (birdsfoot trefoil hay)
14 day preharvest /pregrazing inter-
val through 0.375 pound per acre for
foliar application.
16 day preharvest /pregrazing inter-
val through 0.5 pound per acre for
foliar application.
21 day preharvest /pregrazing inter-
val through 0.75 pound per acre for
foliar application.
Issued: 2-23-85 ITI-058001-10
-------
EPA Compendium of Acceptable Uses
0,0-DIMETHTL S-( ( 4-0X0-1, 2, 3-BENZOTRIAZ£I-3( 4E)-YL)-
METHTL) PHOSPHORODITHIOATE
Site and Pest
ABA
3DA
AAA
ARA
AAA
3WA
BTA
AAA
ABA
>02AA
>03AA
'05AA
)06AA
:AAA
7AAA
UGA
-AAA
Dosages and Tolerance, Use, Limitations
Fonnulatlon(s)
Birdsfoot Trefoil (continued)
Alfalfa plant bug
Fleahoppers
Grasshoppers
Lygus bugs
Spittlebugs
Alfalfa weevil
Egyptian alfalfa
weevil
Leafhoppers
Mites
Blackberry
Boysenberry
Loganberry
Raspberry
Do not make more than 1 application
per cutting through 0,75 pound per
acre.
0.5-0.75 Ib/A Use limited to states East of the
(50% WP) Mississippi River.
Foliar application. Apply when pest
first appears and repeat as needed.
For 'alfalfa weevil and Egyptian al-
falfa weevil in heavy growth, apply
in 20 -to 25 gallons of water per
acre by ground equipment.
0.375-0.75
Ib/A
(50% WP)
0.25-0.5 Ib/A
(50% WP)
2 ppm
14 day preharvest interval through
0.9 pound per acre for foliar appli-
cation of dust formulations.
14 day preharvest interval through
0.5 pound per acre for foliar appli-
cation of sprayable formulations.
3 day preharvest interval through 1
pound per acre for application to
canes and soil.
3o .-.oc -sake ~orz "han I implications
per growing season. Rates above i
pound per acre should be applied
only before fruit set or after the
crop is harvested.
Choppers ?~5~°'9 ^/A *oll« «PPU«tlon. May be applied
Leafniiners ( ' } by aircraft. Apply when pest first
, , ,, or appears and repeat as needed.
Leaf rollers 0.0625 oz/gal May be formulated with ferbam or
Obscure root weevil (l lb/gal EC) sulfur.
(adults) or
2-3 tbls 5%
EC/gal
Aphids
(5% EC)
0.313-0.51
lb/200 gal/A
(25%, 50% WP)
(2 lb/gal EC)
Issued: 2-2S-85
III-058001-ll
-------
EPA Compendium of Acceptable Uses
0,0-DIMETHYL S-((4-0X0-1,2,3-BENZOTRIAZIN-3(4H)-YL)-
METHYL) PHOSPHORODITHIOATZ
Site and Pest
Dosages and Tolerance, Use, Lialcations
FormulationCs)
Blackberry cluster (continued)
Leafhoppers
Leafrollers
Leafminers
0.25 lb/200
gal/A
(25%, 50% WP)
(2 Ib/gal EC)
0.313 lb/200
gal/A
(2 Ib/gal EC)
Obscure root weevil 0.5 lb/200
(adults) gal/A
(25%, 50% WP)
Obscure root weevil 0.5 Ib7200 Soil application. Apply to soil in
gal/A the crown area.
(25%, 50% WP)
(2 Ib/gal EC)
•"> T~
2 tbl.s 5%
" EC/gal
Raspberry crown
borer
Blueberry
1-2 lb/200
gal/A
(25%, 50% WP)
or
2 tbls 5%
EC/gal
(5% EC)
5 ppm
4 hour preharvest interval through
0.6 pound per acre for 2 foliar ap-
plications of dust formulations by
aircraft.
9 hour preharvest interval through
0.6 pound per acre for 5 foliar ap-
plications of dust formulations.
3 day preharvest interval through
0.75 pound per acre for 4 foliar ap-
plications of sprayable :3mula-
tions.
7 day preharvest interval through
0.6 pound per acre for 2 foliar ap-
plications of dust formulations by
ground equipment.
Issued: 2-28-85
111-058001-12
-------
163
SPA Compendium of Acceptable Uses
0,0-DIMETHTL S-((4-OXQ-l,2,3-BENZOTRIAZEJ-3(4H)-TL)-
METHTL) PHOSPHORODITHIOATE
Site, and Pest
Blueberry (continued)
Dosages and Tolerance, Use, Limitations
Fo-rmulation( s)
Blueberry maggot
Fruitworms
Leafminers
Lecanium scales
Plum curculio
14 day preharvest interval through-
0.9 pound per acre for 2 foliar ap-
plications of dust formulations or
1 pound per acre for 2 foliar appli-
cations of sprayable formulations.
Do not spray more than 2 times per
growing season, with the last spray
no later than June 15 if lace season
dust applications are to be made for
blueberry maggot control.
0.6-0.9 Ib/A Foliar application. Dusts may be
(3% D) applied by aircraft. Followed by
another aircraft application or an
application by ground equipment.
0.5-0.75 lb/ Use limited to the Eastern and North
200 gal/A Central United States.
(50% WP) Foliar application. Repeat as need-
(2 Ib/gal EC) ed.
0.5-1 Ib/A
[100-200
gal/A]
(251, 50% WP)
Foliar
ed.
application. Repeat as need-
Boysenberry
B_roccoli
Brussels Sprouts
Cabbage
Cauliflower
See Blackberry cluster.
2 ppra
15 day preharvest interval through
0.75 pound per acre for foliar ap-
plication.
21 day preharvest interval through
0.75 pound per acre for soil appli-
cation.
Aohids
Cabbage looper
Diamondback moth
Imported cabbage-
0.5-0.75 Ib/A Foliar application. Dusts may be
(2%, 3% D) applied by aircraft. Apply when
(25%, 50% WP) pest first appears and repeat as
(2 Ib/gal EC) needed.
or May be formulated with ferbam or
0.083 oz/gal sulfur.
(1 Ib/gal EC)
or
Issued :
2-2S-35
111-058001-13
-------
164-
EPA Compendium of Acceptable Uses
0,0-DIMETHYL S-<(4-0X0-1,2,3-BENZOTRIAZIN-3(4H)-TL)-
METHTL) PHOSPHORODITHIOATE
Site and Pest
Dosages and Tolerance, User Limitations
Formulation^ s)
Broccoli cluster (continued)
Cabbage maggot
2-3 tbls 5Z
EC/gal
(57, EC)
or
5 csp 12.4"
SC/L/gal
"(12.4% SC/L)
0.125-0.19
lb/50 gal
water
(25%, 50% UP)
(2 Ib/gal EC)
or
0.125 lb/50
gal water
(2, 3 Ib/gal
FIG)
Transplant water application. Apply
4 to 6 fluid ounces per plant at or
immediately after transplanting.
Use limit:ed co CA-
(25", 50% WP) Transplant Fields: Transplant water
(2 Ib/gal EC) application. £pp~ly in 300 to 400
(2, 3 Ib/gal gallons of water per acre as a soil
F1C) drench in rows when damage first ap-
oears. Additional applications may
':s nasded.
Direct Seeded Fields: Broadcast
soil application. Incorporate into
the top 2 inches of soil prior to
planting or spray in the seed furrow
at planting time 2 to 3 additional
sprays may be needed.
8 fl.oz 5%
"EC/gal
[0.5 pt/
plant]
(5% EC)
Transplant water application.
Drench soil.
Issued: 2-23-85
-------
165
EPA Compendium of Acceptable Uses
0,0-DIMETHTL S-<(4-0X0-1,2,3-BENZOTHIAZIN-3(4H)-YL)-
METHTL) PHOSPHORODITHIOATZ
Site and Pest.
Celery
Dosages and. - Tolerance-,. Use, Limitations
Formulation(s)
2 ppm
14 day preharvest interval through
1 pound per acre for foliar applica-
tion.
Aphids 0.375-0.5
Leafhoppers lb/100 gal
Leafminers [75-200
Spittlebugs gal/A]
Tarnished plant bug (25% WP)
or
0.5 lb/100
gal
[max. 200'
gal/A]
(50% W-P)
(2 Ib/gal EC)
Cherry
Foliar application,
ed.
Repeat as need-
2 ppm
15 day oreharvest interval through
2.4 pounds per acre for foliar ap-
plication of dust formulations or 5
pounds per acre for foliar applica-
tion of sprayable formulations.
Do not apply more than 8 times per
fruiting season. Do not graze live-
stock in treated orchards or groves
Cherry leafminer
Mineola aoCh
Forbes scale
Fruit flies
Lesser peachtree
borer
San Jose scale
0.25 lb/100
gal
(25Z, 50% WP)
(2 Ib/gal EC)
0.25-0.5 lb/
100 gal
(25%, 50% WP)
(2 Ib/gal EC)
or
0. 042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 5%
Foliar application.
ed.
Repeat as need-
(5% EC)
or
1 tbls 12.4Z
SC/L/gal
(12.4Z SC/L)
Issued: 2-28-35
111-058001-15
-------
EPA compendium of Acceptable- Uses
0,0-DIMETHYL S-<(4-0X0-1,2,3-BENZOTRIA2IN-3(4H)-Y
METHYL) PHOSPHORODITHIOATE
Siteand pest
Cherry (continued)
Dosages and Tolerance, Use, Limitations
Formulation(s)
Eyespotted bud moth 1.Q5-2.4 lb/A Foliar application. May be applied
leaf-
Fmittree
roller
Mite?
Plum curculio
:•::--.= Fruits
(32 D)
or
0.25-0.5 lb/
100 gal
(252, 50% WP)
(2 Ib/gal EC)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 52
EC/gal
(52 EC)
or
1 tbls 12.42
SC/L/gal
(12.42 SC/L)
by aircraft. Apply when pest first
appears and repeat as needed.
May be formulated with ferbam or
sulfur.
2 ppm (citrus fruits)
5 ppm (citrus pulp)
7 day preharvest interval through
7.5 pounds per acre for annual foli-
ar application.
28 day preharvest interval through
7.5 pounds per acre for biannual fo-
liar application.
JQ noc -ake nor^ ir.an _ icplicac:. on;
per fruit year. Do not pick fruit
or do other work involving contact'
with the tree, such as pruning, for
7 days after treatment. Do not
graze livestock in treated orchards
or groves for 21 days after treat-
ment. Citrus pulp may be used as
feed for cattle, sheep and goats.
Consult State Cooperative Agricul-
tural Extension. Service for more
restrictive warnings or limitations
Issued: 2-28-85
111-058001-16
-------
167
EPA Compendium of Acceptable Uses
0,0-BIMETHYL S-< (4-0X0-1,2, 3-BZNZOTRIAZIN-3( -iH)-!!)-
METHYL) PHOSPHORODITHIOATE
Site- and Pest
Citrus Fruits (continued)
Dosages and- Tolerance, Use, Limitations
Formula tlon( s)
Aphids
Black scale
Brown garden snail
Brown soft scale
Chaff scale
Citricola scale
Citrus mealy bug
Citrus rust mite
Citrus thrips
Cottonycushion
scale
riorida red scale
Fruittree leaf-
roller
Fuller rose beetle
Clover scale
Orange tortrix
Purple scale
;aow scales
Western tussock
moth-
'nTniteilies
alifornia red
scale
Clover
Clover-Grass Mixture
0.25-0.375
lb/100 gal
[max. 2,0007
A]
(257,, 501,
62.5% WP)
(2 Ib/gal EC)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 5%
EC/gal
(5% EC)
or
1 cbls 12.4S
SC/L/gal
(12.AZ SC/L)
.Foliar application.
0.375 lb/100
gal
r~ar. :,ooo/
-i i
(25Z, 50% WP)
(2 Ib/gal EC)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 57
EC/gal
(5Z EC)
or
1 cbls 12.&
SC/L/gal
(12.4Z SC/L)
See Alfalfa cluster.
See Alfalfa cluster.
Issued: 2-23-85
111-058001-17
-------
168
EPA Compendium of Acceptable Uses
0, 0-DIMETHYL S-< (,4-OXD-l, 2, 3-BENZOTRLAZIN-3 ( 4H)-YL) •
METHYL) PHOSPHORODITHIOATE
Sice_and Pest
Cotton
Dosages and Tolerance, Use, Limitations
FormulationCs)
0.5 ppm (cottonseed)
1 day preharvest interval through 1
pound per acre for foliar applica-
tion. If late season applications
are made, do not graze livestock on
treated areas or use gin wastes for
feed.
Aphids
Boll weevil
Brown cotton leaf-
worm
Cotton fleahopper
Cocton leafwonn
Lygus bugs
Mites.
Pink bollworm
Rapid plant bug
Stink bugs
i. <3. L i,\ -L S il 6 Q p i a H L ^ '"-* ^
Thrips
Aphids
Soil weevil
Brown cotton leaf-
wonn
Cotton fleahopper
Lygus bugs
Mites
Thrips
3oll weevil
0.48-1 Ib/A
(3Z D)
Foliar application. May be applied
by aircraft. Apply when pest first
appears and repeat as needed.
May be formulated with sulfur.
0.25 Ib/A Foliar application. Apply with low
(2 Ib/gal EC) volume or conventional ground equip-
(2, 3 Ib/gal ment. Apply in a minimum of 1 gal-
F1C) Ion of water per acre. For early
season control of bollworm and pink
toil'.'ora aool'7 0.5 co C.~3 oounci ~^.:
acre.Tor mid to late season con-
trol apply 0.75 to 1 pound per acre.
Repeat as needed.
0.125-0.25
Ib/A
(2, 3 Ib/gal
F1C)
Bollworm
Pink bollworm
0.5-1 Ib/A
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
Rapid plant bug
Tarnished plant
0.25-0.5 Ib/A
bug (2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
Issued: 2-28-85
III-053001-18
-------
EPA Compendium of' Acceptable Uses
0,0-DIMETHYL S-( (4-0X0-1, 2, 3-BENZOTB.IAZ:DI-3( 4H)-i.., -
METHYL) PHOSPHORODITHIOATE
Site and Pest
Cotton (continued)
Stink bugs
Boll weevil
Boll -veevil (dia-
pause adults)
Bollwora
Aphids
Fleahoppers
Thrips
Dosages and Tolerance, Use, Limitations
Pormulation(s)
0.5 Ib/A
(2 Ib/gal EC)
'(2, 3 Ib/gal
F1C)
0.125-0.25
Ib/A
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
—OR MAI—
[W/METHYL
PARATHION]
0.094-0.14
Ib/A
(0.75 Ib/gal
EC)
0.25 Ib/A
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
[W/METHYL
7ARATKION1
0.28 ib/A
(0.75 Ib/gal
EC)
[W/ENDRIN] Foliar application. May be applied
early season by aircraft. Do not use nozzle
0.125 Ib/A liquid pressure greater Chan 40 psi,
(1 Ib/gal EC) Formulated with endrin.
ULTRA LOW VOLUME. Foliar applica-
tion. Apply emulsifiable concen-
trates undiluted and flowable con-
centrates diluted 1:1 (water to
product-). May be applied by air-
craft equipped with low volume
devices that will produce droplets
within the range of 30 to 100 mi-
crons. Make aerial applications at
altitudes of 10 to 20 feet. Repeat
as needed. For bollwonns apply when
larvae are small. Make applications
on a 5 day•schedule. Under heavy
infestation reduce to 3 to 4 days
for 2 or more applications. For
d'iapause 'boll weevil control sched-
ule applications based on local re-
commendations .
OR MAI
Formulated with methyl parathion.
Aphids
Boll weevil
Bollworai
Fleahoppers
Leafworms
mid to late
season
0.133-0.25
Ib/A
(1 Ib/gal EC)
Issued: 2-2S-85
111-058001-19
-------
EPA Compendium of Acceptable Uses
'0,0-DIMETHYL S-( (4-0X0-1, 2, 3-BENZCTXIAZIN-3(4H)-1
METHYL) PHOSPHORODITHIOATE
Site and Pest
Cotton (continued)
Aphids
Boll weevil
Bollworm
Brown cotton leaf-
worm
Cabbage looper
CoCton fleahopper
Cotton leaf per-
forator
Cotton leafworm
Cutworms
Fall armyvorm
Flea beetles
Garden webworm
Grasshoppers
Mices
Plant bugs (includ
ing lygus, rapid,
Dosages and Tolerance, Use, Limitations
FormulationCs)
[W /METHYL
PARATHION]
early season
0.047-0.094
Ib/A
or
mid season
0.094-0.141
Ib/A
or
late season
0.094-0.375
Ib/A
(0.75.1b/gal
EC)
cater-
p Lllar"
5. cirrk bugs
7h rip s- -
Foliar application. Apply in suffi-
cient water for thorough coverage.
For low gallonage ground equipment
apply 6 gallons of finished spray
per acre at 60 psi using 3 nozzles
per row. Apply 3 to 4 gallons per
acre by aircraft.
EARLY SEASON CONTROL should begin
when cotton reaches the 4 leaf stage
or earlier if thrips begin to cause
injury. Make 2 to 4 applications
at 7 to 10 day intervals. Apply
0.07 to 0.94 pound per acre using 1
nozzle per row for thrips, aphids,
and overwintering boll weevils.
MID-SEASON CONTROL should begin when
pest injury is seen or when punctur-
ed squares approach 10 percent.
Make 4 applications at 5 day Inter-
vals. Apply 0.094 to 0.141 pounds
per acre using 3 nozzles per row
vhen bollwora -ggs and 4 or 5 small
larvae are. found per 100 terminals
examined. Apply on a 5 day schedule
as needed.
LATE SEASON CONTROL is a continua-
tion :£ :he ma—season rrcgrara ir.d
is for cne purpose of proceeding
bolls already set from damage by Che
boll weevil and bollwora. Bolls
must be 21 days old to be safe from
boll weevils and almost mature to
be safe from bollworms. Apply on a
4 to 5 day schedule at the rate of
0.25 to 0.375 pound per acre depend-
ing on the size of cotton and the
severity of infestation. Bollvorm,
cabbage looper, saltmarsh cacerpil-
lar and cotton leaf perforator are
controlled by late season rates.
Formulated with methyl parathion.
See Apple cluster.
2-28-35
111-058001-20
-------
T7T
EPA Compendium of Acceptable Usea-
0,0-DIMETHYL S-< ( 4-0X0-1, 2, 3-BENZOTS.IAZIN-3(4H)-TL) -
METHYL) PHOSPHORODITH10ATE
Site and Pest
Cranberry
Dosages and Tolerance, Use, Limitations
Formulation(a)
2 ppm
21 day preharvest interval through
1 pound per acre for foliar applica-
tion.
Cranberry fruitvora Q.6-0.9 Ib/A Foliar application. May be applied
Cra?carry tipwora (2%, 32 D) by aircraft. Apply when pests first
Sparganothis fruit- or appear and repeat at 7 to 10 day in-
worm 0.5-1 lb/200 tervals as needed.
gal/A
(25%, 50Z WP)
(2 Ib/gal EC)
•-•orns
0.6-0.92/A
(27,, 3% D)
or
1 lb/200
gal/A
(25%, 50% WP)
(2 Ib/gal EC)
2 ppm
6 day preharvest interval through
0.5 pound per acre for foliar appli-
cation.
Do not make more than 3 applications
per growing season.
beetle
."trioed cucumber
: •_> e tie
..:escsrn striped
cucumber beetle
Eggplant
(25%, 50% WP)
(2 Ib/gal EC)
or
0.0625 oz/gal
(1 Ib/gal EC)
or
2 tbls 5%
EC/gal
(5% EC)
0.3 ppm
Do not apply after fruit set through
0.5 pound per acre for foliar appli-
cation.
European corn borer 0.5 Ib/A Foliar application.
Flea beetles (25%, 50% WP)
(2 Ib/gal EC)
Issued:
111-058001-21
-------
EPA Compendium of Acceptable Uses
0,0-DIMETEYL S-< ( 4-OXD-l, 2, 3-BENZCTaiAZHT-3( 4H) -*fL) -
METHYL) PHOSPHORODITHIOATE
Sitfrand.Pest
Eggplant (continued)
Leaf miners
Filbert
A:-* .2 mealybug
-^TT: aphid
'.'-ja.rt leaf-
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.375-0.5
Ib/A
(25Z, 50Z WP)
(2 Ib/gal EC)
or
0.0625 oz/gal
(1 Ib/gal EC)
0.3 ppm
30 day preharvest interval through
7 ..5 pounds per acre for foliar ap-
plication.
Use limited to the Pacific North-
west.
Do not graze livestock in treated
groves for 21 days after treatment.
0.25-0.75
Ib/lQO gal
water
[max. 1,000
gal/A]
(25Z, 50% WP)
(2 Ib/gal EC)
or
2 tbls 57,
Foliar application. Do not apply
the high dosage after husk split.
Repeat as needed.
C)
5 ppm
No preharvest interval through 0.7
pound per acre for foliar applica-
tion of dust formulations or 0.75
pound per acre for foliar applica-
tion of sprayable formulations.
10 day preharvest interval through
0.9 pound per acre for foliar appli-
cation of dust formulations or 1.13
pounds per acre for foliar applica-
tion of sprayable formulations.
28 day preharvest interval through
1.5 pounds per acre for foliar ap-
plication of sprayable formulations.
Do not make more, than 3 applications
per fruit year.
Issued: 2-28-85
111-058001-22
-------
173
EPA Compendium of Acceptable Uses
^ 4H)-TL)-
0,0-DIMETHYL S-( (4,-OXO-l, 2, S-
METHTL) PHOSPHORODITHIOATE
Site and Peat
Grapes (continued)
Flea beetles
Grape berry moth
Grape cane glrdler
Grape mealy bug
Leafhoppers
Leaf rollers
Mites
Redbanded leaf-
roller
Thrips
Loganberry
Melons
Leafhoppers
Leafminers
Dosages and Tolerance, Use, Limitations
Formulat ion( s.)
0.6-0.9 Ib/A
(22, 32 D)
or
0.25-0.5 lb/
100 gal
[max. 300
gal/A]
(252, 50Z WP)
(2 Ib/gal EC)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 57,
EC/gal
(52 EC)
or
1 tbls 12.4%
SC/L/gal
(12.42 SC/L)
0.375-0.5
Ib/A
(252, 50% WP)
(2 Ib/gal EC)
or
0.0625 oz/gal
(1 Ib/gal EC)
or
2 tbls 57,
EC/gal
(57. EC)
Foliar application. Dusts may be
applied by aircraft. Apply when
pest first appears and repeat as
needed..
May be formulated with ferbam or
sulfur.
See Blackberry cluster.
2 ppm
No orsharvest interval through 0.5
pouna per acre :3r foliar applica-
tion.
Do not make more than 4 applications
per growing season.
Foliar application.
Issued: 2-28-85
111-058001-23
-------
EPA cotapendlum of. Acceptable Uses.
Siteand
Melons (continued)
Rlndwonns
Spotted cucumber
beetle
Striped cucumber
beetle
Western striped
cucumber beetle
Nectarine
Oats
Onions, Dry
0 , 0-DIMETHYL S-< ( 4-0X0-1 , 2, 3-BENZOTRIA2IN-3 ( 4H) -YL ) -
METHYL) PHOSPHORODITHIOATE
Dosages and Tolerance, Use, Limitations
Fonaulation(s)
0;5 Ib/A
(252, 502 WP)
(2 Ib/gal EC)
or
0.0625 oz/gal
(1 Ib/gal EC)
or
2 this 5%
EC/gal
(52 EC)
See Apricot cluster.
See Barley cluster.
2 ppm
28 day preharvest interval through
0.75 pound per acre for foliar ap-
plication.
Do noc make uiore than 3 applications
per growing season.
0.5-0..5 Ib/A Foliar application.
(32 D) May be formulated with sulfur.
0.5-0.75 Ib/A
, 502 WP)
Onions, Green
Thrips
or
2 tbls 5%
EC/gal
(52 EC)
2 ppm
7 day preharvest interval through
0.75 pound per acre for foliar ap-
plication.
Do not make more than 3 applications
per growing season.
0.5-0.75 Ib/A Foliar application.
(50Z WP)
(2 Ib/gal EC)
Issued: 2-28-85
111-058001-24
-------
EPA Compendium of Acceptable Uses
0,0-DIMETHYL S-((4-0X0-1,2,3-BEMZOTRLAZIN-3(4E)-YL)-
METHTL) PHOSPHORODIT3IOATE
Site and Pest
Pasture Grasses
Grasshoppers
Meadow spittlebugs
(adults)
Peach
fear
Peas, Field
Dosages and Tolerance, Use, Limitations
Formulation( s)^
2 ppm (grass pasture (green))
5 ppm (grass pasture hay)
16 day preharvest/pregrazing inter-
val through 0.5 pound per acre for
foliar application.
21 day preharvest/pregrazing inter-
val through 0.75 pound per acre for
foliar application.
Do not make more than 1 application
per cutting through 0.75 pound per
acre.
0.5-0.75 Ib/A Use limited to states East of the
(25% WP) Mississippi River.
(2 Ib/gal EC) Foliar application.
by aircraft.
May be applied
See Apricot cluster.
See Apple cluster.
0.3 ppm
7 day preharvest interval through •!
pound per acre for foliar applica-
tion of dust formulations and 0.5
pound per acre for foliar applica-
tion of sprayable formulations.
Do -.oc ~
aor= :han ^ j
per growing season. Do noc ase
vines for feed or forage. Do not
?raze created areas.
Corn earworn
Covpea curculio
Leafminers
Stink bugs
1 Ib/A
(3Z D)
or
•0.75-1 Ib/A
(251, 50% WP)
(2 Ib/gal EC)
0.45-1 Ib/A
(3% D)
or
0.375-0.5
ib/A
(252, 502 WP)
(2 Ib/gal EC)
Foliar application.
by aircraft.
May be applied
Issued: 2-28-35
111-053001-25
-------
EPA Compendium of Acceptable Uses.
0,0-DIMETHYL S-((4-0X0-1,2,3-BENZOTRIAZIN-3(4H)-Yl)- •
METZYL) PHOSPHORODITHIOATZ
Site and Pest'
Pecan
Aphids
Fall webworm
'iickory shuckworm
Leaf miners
May beetles
•'.ices
Pecan casebearer
Southern green
stink bug
Spittlebugs
~?vig girdler
'::aiaut. caterpillar
Dosages- and Tolerance, Use, Limitations
Fonmilaticm(s> " " ~~
0.3 ppm
Do not apply after husk split
through 10 pounds per acre for
foliar application.
Do not graze livestock in treated
orchards or1 groves for 21 days fol-
lowing treatment through 5.6 pounds
per acre. If higher rates are ap-
plied do not graze.
0.375-0.56
lb/100 gal
[max. 1,800
gal/A]
(25%, 50% WP)
(2 Ib/gal EC)
or
0.083 oz/gal
(1 Ib/gal EC)
.or
2-3 tbls 5%
EC/gal'
or
1 -this 12.4%
SC/L/gal
(12.4% SC/L)
Foliar application.
by aircraft.
May be applied
0.3 ppm
3 day preharvest interval through
j.l pound per _ic re for - ::iiar im-
plications.
14 day preharvest interval through
0.5 pound per acre for more than 4
foliar applications.
European corn borer 0.5 Ib/A
Flea beetles
Foliar application.
50% WP) by aircraft.
May be applied
(257,
or
0.0625 oz/gal
(1 Ib/gal EC)
or
2 tbls 5%
EC/gal
(5% EC)
or
3 tsp 12.4%
SC/L/gal
(12.4% SC/L)
Issued: 2-28-85
111-058001-26
-------
EPA Compendium of Acceptable Uses.
0,0-DIMETHYL S-((4-0X0-1,2,3-BENZOTRIAZET-3(4H)-TL)-
METHYL) PHOSPHORODITHIOATE
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
Pepper (continued)
Leafminers
1AA
Pistachio Nuts
0.375-0.5
Ib/A
(251, 50Z WP)
(2 Ib/gal EC)
or
0.0625 oz/gal
(1 Ib/gal EC)
or
2 tbls 5%
EC/gal
(51 EC)
or
3 tsp''12.4%
SC/L/gal
(12.4% SC/L)
0.3 ppm
Foliar treatment. This use occurs
only on Special Local Need (24-C)
labeling.. Refer to appropriate
labeling for use information and
limitations.
CA790139
CA790149
.ME
3GA
ALA
2 opm (plums (fresh prunes))
LJ -ar ^reharvesc inC2r~,*al :hrough
2.5 pound per acre for foliar appli-
cation.
Do not make more than 3 applications
per fruit season. Do not graze
livestock in treated orchards or
groves for 21 days after treatment.
American plum borer 0.5 lb/100
Orange tortrix gal
(25%, 50% WP)
Foliar application. Apply at petal
fall and repeat at 10 to 14 day in-
tervals. For control of scales,,ap-
(2 Ib/gal EC) ply when crawlers are present. For
peach cvig borer apply Che high rate
before mid-season.
or
0.042 oz/gal
(1 Ib/gal EC)
Issued: 2-23-85
111-058001-27
-------
EPA Compendium of Acceptable Uses
0,0-DXMETHYL S-( ( 4-0X0-1, 2, 3-3ENZOTRLAZIM-3( 4H)-':
METHYL) PHOSPHORODITHIOATE
Site- and Pest
Dosages and Tolerance, Use, Limitations
Formulation(-s)
Plum cluster (continued)
Aphids
Eyespotted bud noth
Forbes scale
Fruittree leaf-
roller
Lesser peachtree
borer
Mites
Peach twig borer
Plum curculio
Redbanded leaf-
roller
San Jose scale
Stink .bugs
Tarnished plant bug
Tussock moths
0.25-0.5 IV
100 gal
(25%, 50% WP)
(2 Ib/gal E-C)
or
0.042 oz/gal
(1 Ib/gal EC)
or
2-3 tbls 5Z
EC/gal
(5% EC),
or
1 tbls 12.4%
SC/L/gal
(12.4% SC/L)
Aphids ]__ Q5-2, 4 1
Eyespotted bud moth (3% D)
Fruittree leaf-
roller
Mites
Peach'-'twig borer
Redbanded leaf-
roller
b/A Foliar application. May be applied
by- aircraft. Apply when pest first
appears and repeat as needed.
Mav be formulated with sulfur.
r-eacacree oorer
Potato
^._^ •_., _ _j, 3arx applications. Apply co -
100 gal sprays to trunk between ground and
(25%, 50% WP) scaffold limbs, timed with moth
(2 Ib/gal EC) flight.
or
0.042 oz/gal
(1 Ib/gal EC)
0.3 pptn
7 day preharvest interval through
0.75 pound per acre for foliar ap-
plication.
Aphids
Colorado potato
beetle
European corn borer
Flea beetles
Leafhoppers
Leafminers
Potato tuberworm
0,45-0.75
Ib/A
. „., ,« n x
V -J, , -//« U )
or
0.083 oz/gal
(1 Ib/gal EC)
or
Foliar application. May be applied
by aircraft. Apply when pest first
appears and repeat as needed.
May be.formulated with sulfur.
Issued: 2-28-35
111-058001-23
-------
•A
'A
?A
U.
:A
JA
GA
PA
'8BA
179 • .
EPA Compendium of Acceptable Uses
0,0-D1METHZL-S-((4HJXO-1,2,3-BENZOTRIAZIN-3(4H)-YL)-
METHYL) PHOSPHORQDITHIOATS
Site and Pest
Potato (continued)
Dosages and Tolerance, Use, Limitations
Foraulation(s)
Pest list continued from previous page,
Spitrlebugs 2 tbls 51
Tarnished plant bug EC/gal
(5% EC)
or
5 tsp/12.4%
SC/L/gal
(12.4% SC/L)
0.6-0.75 Ib/A
( 3% Q)
or
0.5-0.75 Ib/A
(25%, 50% WP)
(2 Ib/gal EC)
0". 375-0. 5
Ib/A
(252, 50% -J?)
or
0.375 Ib/A
(2 Ib/gal EC)
(257., 50% WP)
(2 Ib/gal EC)
0.56-0.75
Ib/A
(25Z, 50% WP)
(2 Ib/gal EC)
European corn borer
Flea beetles
Leafhoppers
Potato tubervora
Spittlebugs
Tarnished plant bug
Banded cucumber
beetle
Leafminers
-o-oraco poca;:
beetle
Leafminers
Potato tubervonn
Prune
Quince
Raspberry
?.ve
Safflover (seed crop)
Thri^s
See Plum cluster.
See Apple cluster.
See Blackberry cluster.
See Barley cluster.
N.F.
0.5-0.75 Ib/A Foliar application to seed crop,
(25% WP) Repeat as needed.
Issued: 2-28-85
111-058001-29
-------
j_au
EPA Compendium- of Aceep-ta.ble Uses
0,0-DIMETHYL S-( C4-0X0-1, 2,'3-BENZOTRIAZ2T-3( 4H)-'fL) -
METHYL) PHOSPHORODITHIOATE
Site and Past
Soybeans
Dosages and Tolerance-, Use» Limitations
Formulation(s)
0.2 ppm (soybeans)
1.0 ppm (soybean oil)
45 day preharvest interval through
0.9 pound per acre for foliar appli-
cation of dust formulations.
21 day preharvest" interval through
•0.75 pound per acre for foliar ap-
plication of sprayable formulations.
Do not graze or feed treated vines
to livestock.
Aphids
Bean leaf beetle
Green cloverworm
Leafhoppers
Leafminers
Leafrollers
Stink bugs
Velvetbean cater-
pillar
0.45-0.6 Ib/A Foliar application. May be applied
(3% D) by aircraft. Repeat as needed.
or OR MAI
0.375-0.5 Formulated with methyl parathion.
Ib/A
(25%, 50% WP)
(2 Ib/gal EC)
—OR MAI—
fW /METHYL
PARATHION]
•J. 094-0. 25
Ib/A
(0.75 Ib/gal
EC)
PARATHION]
0.234
(0.75 Ib/gal
EC)
Mexican bean beetle 0.6-0.9 Ib/A
(3Z D)
or
0.5-0.75 Ib/A
(25%, 50% WP)
(2 Ib/gal EC)
—OR MAI —
[W/METHYL
PARATHION]
0.25 Ib/A
(0.75 Ib/gal
EC)
Issued: 2-23-35
111-058001-30
-------
EPA.- Compendium- of Acceptable Uses •
0,0-DIMZTHYL S-( (4-0X0-1, 2, 3-BENZOTRIA2O-3(4H)-YL)-
METHYL)'PHOSPHORODITHIOATZ
4AA
Site and Pest
Spinach
Dosages and Tolerance, Use, Limitations
FonmilationC s)
2 ppm
14 day preharvest interval through
0.75 pound per acre for foliar ap-
plication of dust formulations.
14 day preharvest interval through
0.5 pound per acre for foliar ap-
plication1 of wettable powder and
emulsifiable concentrate formula-
tions.
AA
.GA
.3 A
Aphids
Leafminers
Mites
0.45-0.75
Ib/A
(2, 3% D)
or
0.375-0.5
Ib/A
(25%, 50% WP)
(2 Ib/gal EC)
or
0.0625 oz/gal
(1 ib/gai EC)
or
1 fl.oz 5%
Foliar application. Apply when pest
first appears and repeat as needed.
May be formulated with sulfur.
L6AA
AAA
AKA
AVA
DMA
AWA
D?A
I PA
.ADA
AAA
(57. EC)
Strawberry 2 ppm
5 dav preharvest interval through
3,5 pound per ic r2 for foliar appli-
cation.
Apply wettable powder formulations
in 200 gallons of water per acre.
Aphids 0.5 Ib/A Foliar application. May be applied
Meadow spittlebug (2% D) by aircraft. Apply when pest first
Obliquebanded leaf- (25%, 50% WP) appears and repeat as needed.
roller
Obscure root weevil
Omnivorous leaf tier Q.0625 oz/gal
Pea leaf weevil
Small black grass
weevil
Strawberry leaf-
roller
Whiteflies
(2 Ib/gal EC)
or
(1 Ib/gal EC)
or
2-3 tbls 5%
EC/gal
(5% EC)
Issued: 2-23-35
111-058001-31
-------
L82.
EPA Compendium of Acceptable Uses
0 ,-0-DIMETHYL S-C ( 4-0X0-1, 2, 3-3ENZOTRLAZIN-3 (4H) -YL)
METHYL) PHOSTHORODITHIOATE
Site and Pest
Sugarcane
Sugarcane borer
Tomato
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.3 ppm (sugarcane)
1.5 ppm (sugarcane bagasse)
30 day preharvest interval through
1 pound per acre for foliar applica-
tion.
Do not make more than 5 applications
per season. Bagasse may be used as
feed for cattle, sheep, and goats.
Consult your State Cooperative
Agricultural Extension Service for
specific information in your area.
1 Ib/A
(5%, 77,,
G)
0.75 Ib/A
Broadcast application. Apply by
10% aircraft.
Use limited to LA, FL, and TX.
(2 Ib/gal EC) Foliar application, conventional
(2, 3 Ib/gal spray. Apply by aircraft in a mini-
F1C) mum of 2 gallons of water per acre.
Apply at cane top level not to ex-
ceed' 10 feet above cane top level.
Use limited to LA, FL, and TX.
ULTRA LOW VOLUME. Foliar applica-
tion. Apply emulsifiable concen-
trates undiluted and flowable con-
centrates diluted 1:1 (water to
?r?duct). Aircraft nust be equipped
vi;r. _ow volume iavicss :.~.uc J"1
product droplets within the range
of 30 to 100 microns. Apply at cane
top level not to exceed 10 feet
above cane top level.
2 ppm
No preharvest interval through 0.75
pound per acre for foliar applica-
tion.
14 day preharvest interval through
1.5 pounds per acre for foliar ap-
plication.
Aphids
European combora:
Flea beetles
Ho rnwo rms
Leafhoppers
Thrips
0.6-0.75 Ib/A Foliar application. May be applied
(27, 5% D) by aircraft. Apply when pest first
or appears and repeat as needed. Apply
0.5-0.75 Ib/A the high rates when heavy infesta-
(25Z, 50% WP) tions of late instar lepidopterous
(2 Ib/gal EC) larvae and pinworms are present.
or 'May be formulated with sulfur.
Issued: 2-28-85
:iI-058001-32
-------
3JA
AAA
183
. EPA Compendium of Acceptable Uses
0,0-D3METHYL S-< ( 4-0X0-1, 2, 3-BENZOTRIAZIN-3( AH.)-YL)-
METHTL) PHOSPHORODITHIOATE
Site and Pest-
Tomato (continued)
Banded' cucumber
beetle
White flies
Dosages and Tolerance, Use, Limitations
Formulatipn(s)
0.083 oz/gal
(1 Ib/gal EC)
or
2 tbls 57,
EC/gal
(5% EC)
or
5 tsp 12.4%
SC/L/gal
(12.4% SC/L)
0.375-0.5
Ib/A
(25%, .50% WP)
(2 Ib/gal EC)
or
0.083 oz/gal
"(1 Ib/gal EC)
or
2 tbls 51
EC/gsl
(57. EC)
or
5 tsp 12.4%
SC/t/gal
CFA
ABA
ACA
AGA
Colorado potato
- beetle
Drosophila
Green stink bug
Leafaiiners
0.44-0.75
Ib/A
(2%, 3% D)
or
0.375-0.5
Ib/A
(25%, 50% WP)
(2 Ib/gal EC)
or
0.083 oz/gal
(1 Ib/gal EC)
or
2 tbls 5%
EC/gal
(57, EC)
or
5 tsp 12.4%
SC/L/gal
(12.4% SC/L)
Issued: >2S-35
IZI-058001-33
-------
184-
EPA Compendium of Acceptable- Uses
0,0-DIMETHYL S-((4-0X0-1,2,3-BENZDTRIA2IN-3(4H)-TL)-
METHYL) PHOSPHORODITHIOATE
Site and Pest
Tomato (continued)
Colorado potato
beetle
Grasshopper
Fruit worms
Ho rnwo rms
Tomaco pinwor=
Toraa-to fTuitwonn
Yellowstriped
armyworm
Tuoervonns
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.375 Ib/A
(2 Ib/gal EC)
0.5-0.75 Ib/A
(25%, 50% UP)
(2 Ib/gal EC)
or
0.083 oz/gal
(1 Ib/gal EC)
or
2 this 5%
EC/gal
(5% EC)
or
5 tsp 12.4%
SC/L/gal
(12.4% SC/L)
0.7-0.75 Ib/A
(22, 3% D)
or
0.75-1.5 Ib/A
(25%, 50%.WP)
(2 Ib/gal EC)
or
•, -> jj— . _ , _ _ ^
(1 Ib/gal EC)
or
2 this 5%
EC/gal
(5% EC)
or
5 tsp 12.4%
SC/L/gal
(12.4% SC/L)
0.56-0.75
Ib/A
(2 Ib/gal EC)
or
0.083 oz/gal
(1 Ib/gal EC)
or
2 this 57,
EC/gal
^5% EC)
or
Issued: 2-28-35
111-058001-34
-------
18.5
EPA Compendium of Acceptable Uses
0,a-DIMETHYL S-( (.4-0X0-1,2, 3-BENZOTRIAZ321-3(4H)-YL)-
METHTL)'PHOSPHORODITHIOATE
Site and Pesr
Dosages and. Tolerance, Use, Limitations
Formulation(s)
Tomato (continued)
5 tsp 12.42
SC/L/gal
(12,42 SC/L)
.OBA Vetch (seed crop)
.AA Aphids
>iAA Bruchids /seed
weevils
0.5 Ib/A
(25% WP)
N.F.
Foliar application to seed crop.
39AA
Walnuts
0.3 ppm
Do not apply after husk split
throug~h 10.34 pounds per acre for
foliar application.
Do not 'graze livestock in treated
groves for 21 days after treatment.
AZA
.ASA
BBA
CFA
Apnids
Codling moth
Eurooean red mice
Filbertvorm
Na-vel orangewonn
0.9-i.5 Ib/A Foliar appllcacion. May be applied
(2%, 3% D) by aircraft.
or
0.25—D.9u lb/
100 gal
[max. 1,100
gal/A]
(25%, 50% WP)
or
2-3 tbls 5%
EC/gal
(5% EC)
0.25-0.94 lb/
100 gal
[max. 1,100
gal/A]
(25%, 50% WP)
(2 Ib/gal EC)
Wheat
See Barley cluster.
Issued: 2-28-85
111-058001-35
-------
186-
EPA Compendium of Acceptable Uses
0,0-DIMETHYL S-(( 4-0X0-1, 2, 3-BENZOTRIAZIN-3(4H)-YL)-
METETL) PHOSFHORODITHIOAT2.
Site and Pest
TERRESTRIAL NON-FOOD CROP
(Agricultural Crops)
Tobacco
Dosages, and Tolerance-, Use, limitations
Fornmlation( s)
N.F.
6 day preharvest interval through
0.75 pound per acre for foliar ap-
plication.
Begin application immediately fol-
lowing transplanting. Prime before
treating.
Aphids
Grasshoppers
Tobacco flea
Tobacco hornworm
0.5-0.75 Ib/A Foliar application. Begin applica-
(3% D) tions immediately after transplant-
beetle (25%, 50% WP) ing. Apply when pest first appears
(1, 2 Ib/gal and repeat at 7 day intervals as
EC) needed. For tobacco budworm apply
(12.37% EC)** dust formulations directly to the
bud. For tobacco flea beetle 2 ap-
OR MAiplications may be needed beginning
Aug-ust 1 and repeated 14 days later.
For tobacco hornworm apply as soon
1] as £gg masses or larvae are first
lb/25- found. The- second brood may require
40 gal/A 2 applications beginning late July
(0.25 Ib/gal and another in August.
EC) OR MAI
[W/PARA-
~ 3rrr.il a ted vt:h 3ar.ithi.on.
Tobacco budworn
0.7-0.75 Ib/A
( ?% 3% D)
(25%, 50% W?)
(1, 2 Ib/gal
EC)
(Ornamental Plants and Forest Trees)
Ornamental Plants (including shade
trees and nursery stock.)
Aphids
Lacebugs
Leafhoppers
Mites
Thrips
0.6-0.75 Ib/A Foliar application. Thorough cover-
(2%, 3« D) age is essential for control. For
or European pine shoot moth and tha
Nantucket pine tip moth time appli-
cationsto coincide with moth
flight.
May be formulated with sulfur.
Issued: 2-28-85
111-058001-36
-------
.187
EPA Compendium of Acceptable Uses
0,0-DIMETHYL S-C(*-OXQ-1>2,3-BENZOTRIAZIN-3(4H)-YL)-
METHYL) P.HOSPHORODITSIOAIE
Site and Pest
Dosages- and. Tolerance, Use,. Limitations
Fbrmulation(s)
Ornamental Plants (including shade trees and nursery stock) (continued)
0.375-0.5 lb/
100 gal
(25%, 50% WP)
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
or
0.25-0.5 csp
actual*/gal
(25%, 50% UP)
or
0.0625-0.083
oz/gal
(1, 2 Ib/gal
EC)
(2, 3 Ib/gal
F1C)
LA
5-jL^k pineleaf
s carl a-
,GA
•-SA
Erc<.m soft scale
Pucnan scale
0.75-1 lb/ ,
100 gal
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
or
c bis ac cu—
al*/gal
(25%, 50% WP)
or
0.125 oz/gal
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
1 lb/100 gal
(25%, 50% WP)
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
or
0.75 cbls
actual*/gal
(25%, 50% WP)
or
Issued: 2-23-85
III-058001-3;
-------
188
EPA Compendium of Acceptable Uses
0,0-DIMETHYL S-( (4-OXO-l, 2,.3-BENZOTRIAZIU-3(4H)-TL)-
METHTL) PHOSPHORODITHIOATE
Site- and Pest
Dosages and Tolerance, Use, Limitations
FormnlationCs)
Ornamental Plants (including shade trees and nursery stock) (continued)
O.T25 oz/gal
(2 Ib/gal EC)
(2, 3 Ib/gal
FIG)
Cerococcus scales
Euonymus scales
.Juniper scale
Olive scale
Oystershell scale
0.375-0.5 lb/
100 gal '
(25%, 50% WP)
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
or
0.25-0.5 tsp
actual*/gal
(25%, 50% WP)
or
0.0625-0.083
oz/gal
(2 Ib/gal EC)
(2, 3 Ib/gal
European pine shoot o.6-0.75 Ib/A
moth. (27,, 3% D)
Nantucket pine tip or
I b / A
(25%, 50% WP)
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
or
0.5 tbls
actualVgal
(25%, 50% WP)
or
0.125 oz/gal
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
Issued: 2-28-85
311-058001-38
-------
EPA Compendium of Acceptable Uses
0,0-DIMETHYL S-((4-0X0-1,2,3-BENZOTRLAZLN-3(4H)-TL)-
METHTL) PHOSPHORODITHIOATE
Site and.Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Ornamental Plants (including shade trees and nursery stock) (continued)
'A Cone midges 2-4' lb/100 Foliar application. For cone moths/
>A Cone moths/cone gal water cone worms, time applications to
worms (25%, 50% WP) coincide with moth flight when
(2 Ib/gal EC) cones are open for pollination.
(2, 3 Ib/gal Thorough coverage of cones is es-
F1C) sential for effective control. Re-
peat as needed.
FORESTRY
DAA Forest Trees
Refer to TERRESTRIAL NON-FOOD CROP, (Ornamental
Plants and Forest Trees), Ornamental Plants for
additional information.
9AA Pine Plantations
£A European pine shoot 0.45-0.9 Ib/A Foliar application. Apply when pest
soth (3% D) first appears and repeat as needed.
LA Nant.ucket,. pine tip
moth
4BA Slash Pine (seed orchards)
-^ Cone mo ens, cone j.. 5 lb/.GO Jollar appiicscion. Thorougn cover-
worms gal age is essential for effective con-
AA Seedworas (25%, 50% WP) trol.
(2 Ib/gal EC)
'5BA Southern Pine (seed orchards)
JDA Cone moths/cone 0.2% finished Foliar application to seed orchards.
woms sPray Apply first application within 30
;AA Seedworms [5-10 gal/ days following conelet closure, fol-
Cree] lowed by 3 to 5 applications 30 days
°r apart. Thorough coverage of cones
1% finished is essential.
spray
[1-2 gal/
(2 Ib/gal EC)
(2, 3 Ib/gal
F1C)
Issued: :-23-35 III-058001-39
-------
~i^U
EPA' Compendium of Acceptable Uses
0',0-DIMETHYL S-( ( 4-0X0-1,2, 3-BENZOTRLA2IN-3( 43)-TL)-
METHTL) -PHOSPHORODITHIOATS
Site- and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
AERIAL, MOTHPROOFING AND TANK MIX APPLICATIONS
Aerial Application
Refer to
TERRESTRIAL FOOD CROP"
(Agricultural Crops)
All sites
TERRESTRIAL NON-FOOD CROP
(Agricultural Crops)
All sites
(Ornamental Plants and Forest Trees)
All sites
FORESTRY
(Ornamental Plants and Forest Trees)
All sites
-ssued: >23-35 III-058001-AO
-------
EPA Compendium of'Acceptable Uses
0,0-DIMETHYL S-((4-0X0-1,2,3-BENZOTRIAZI5-3(4H)-TL)-
METHYL). PHOSPHORODITHIOAIE
Listing of. Registered Pesticide Products by Formulation
i.0001 852 technical chemical
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001)
003125-00108 011678-00004
i.OOOl 94% technical chemical
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioace (058001)
002749-00291 010163-00095
L.0002 1 Ib/gal formulation intermediate
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001) and xylene (086802)
003125-00225
5.0002 25% formulation intermediate
0,0-dimethyl S-((4-oxo-l, 2, 3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001)
003125-00153
1.0002 21% formulation intermediate
0,0-dimethyl S-((^-oxo-1,2,3-benzotriazin-3(4H)-7i)mechyl) phosphoro-
dithioate (058001), 0,0-diethyl S-( (4-oxo-l,2,3-benzotriazin-3(4H)-yl)
phos-phorodichioace (058002) plus aromatic petroleum distillate (006601)
003125-00179
2.0002 22% formulation intermediate
0 ,0-dimethyl S-( ( 4-oxo-l, 2 ,-3-benzot riazin-3( 4H)-yl)methyl) phosphoro-
dithioate (058001) plus aromatic oetroleum distillate (006601)
2.0003 2% dust
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro
dithioate (058001)
000279-02111*!? 000802-00310 002393-00191
Suspended
^jacket currently unavailable for review
2.5003 2.5% dust
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro
dithioate (058001), rineb (014506) plus captan (081301)
003743-00271
)3.0003 3% dust
0,0-dize^hyl S-(f4-oxo-l,2,3-benzoCriazin-3(4H)-yl)methyl) phosphoro
dithioate (058001)
000279-01945 000279-02022 000635-00361 003125-00063
005905-00318 008590-00190
Issued: 2-23-85
111-058001-41
-------
of Acceptable Uses
0,0-DIMETHYL S-(( 4-0X0-1, 2, 3-BENZOTRIA2IN-3( 4H)-TL)-
METHYL) PEOSPHORODrTHIOATS
Listing of Registered Pesticide Products by Formulation (continued)
% dust (continued)
0,0-dimethyl S-((4-o:xo-l, 2, 3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001) plus ferbam (034301)
000279-02234*
*suspended
0,0-dimethyl S-(( 4-oxo-l, 2, 3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001) plus sulfur or sulphur (077501)
000279-01827* 000279-02261* 000595-00254
*suspended
0,0-dimethyl S-((4-oxo-l, 2, 3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001) plus captan (081301)
008590-00094
0,0-dimethyl S-(( 4-oxo-l, 2, 3-benzocriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001), sulfur or sulphur (077501) plus captan (081301)
008590-00163
6% dust
0,0-dimethyl S-(( 4-oxo-l, 2, 3-benzotriazin-3(4H)-yl) methyl) phosphoro-
dithioate (058001) plus captan (081301)
000477-00254* 008590-00071
*suspended
5% granuLar.
0,0-dimethyl S-((4-oxo-l, 2, 3-benzotriazin-3( 4H)-yl)methyl) phosphoro-
dithioate (058001)
00027a-0277S*
77, granular
0,0-dimethyl 5-( ( 4-oxo-l , 2 , 3-benzot riazin-3( 4H)-yl) methyl) phosphoro-
dithioate (058001)
000400-00229 0031 25-001 67
10% granular
0,0-diraethyl S-( ( 4-oxo-l , 2, 3-benzot riazin-3t 4H)-yl)methyl) phosphoro-
dithioate (058001)
003125-00132
25% vettable powder
0,0-dimethyl S-( ( 4-oxo-l, 2, 3-benzot riazin-3( 4H)-yl)methyl) phosphoro-
dlthioate (058001)
003125-00025
Issued: 2-28-85 111-058001-42
-------
EPA Compendium,of Acceptable Uses
0,0-DIMETHYL S-((4-0X0-1,2,3-BENZOTRIAZIN-3(4H)-TL)-
METHYL) PHOSPHORODITHIOATE
Listing of Registered Pesticide Products by Formulation (continued)
i 0006 50% wettable powder
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001)
000707-00157 000707-00158 002749-00263 003125-00193
003125-00301 007001-00263 010163-00078 046077-00007
i
5006 62.5Z vettable powder
0 ,0-dimethyl S-((4-oxo-l, 2, 3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioace (058001)
003125-00260
i
2512 0.25 Ib/gal emulslfiable concentrate
0,0-dimethyl S-((4-oxo-l, 2, 3-b.enzotriazin-3( 4H)-yl)methyl) phosphoro-
dithioate (058001), parathion (057501)' plus xylene (086802)
004185-00459
7512 ,.'"; Ib/gal enulsifiable concentrate
n,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
J.lthioace (058001), aromatic petroleum derivative solvent (006501) plus
^,0-dimethyl 0-p-aitrophenyl phosphorothioate (CT53501)
000769-00439
0-diaethyl S-((4-6xo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
•-"Lthioatar (058001), aromatic petroleum distillate (006601) plus 0,0-
:i^2Chyl 0-p-r.i'tr:rher.yl phosohorothioate (053501)
009779M30191.
,^-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
•Jithioace (058001), 0,0-dimethyl 0-p-nitrophenyl phosphorothioate
r53:0i' ?lus ,rTL2r.2 ' ;S6o02"~
OOS934-00077 G^H3I7-00025
0,0-diaethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001), aromatic petroleum distillate (006601), 0,0-dimeth-
yl 0-p-nitrophenyl phosphorothioate (053501) plus xylene (086802)
003125-00271 005905-00247 034704-00020
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001), aromatic petroleum distillate (006601), 0,0-dimeth-
"1 0-p-nitrophenyl phosphorothioate (053501) plus xylene range aromatic
solvent (086803)
001258-01039
.0012 1 Ib/gal emulsifiable concentrate
0,0-diraethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001) plus aromatic pe-troleura distillate (006601)
004185-00472*
*suspended
Issued: 2-23-85 111-058001-43
-------
EPA Compendium of Accepca-bls Uses.
0, 0-DIMETHYL S-( ( 4-0X0-1, 2, 3-BENZOTHIAZIN-3( 4H)-TL) -
METHYL) PHOSPHORODITHIOATE
Listing of Registered. Pesticide Products by- Formulation (.continued)
1 Ib/gal emulsifiable concentrate (continued)
0, 0-dimethyl S-( ( 4-oxo-l , 2, 3-benzotriazin-3( 4H)-yl) methyl) phosphoro-
dithioate (058001) plus xylene (086802)
003125-00138 003342-00072 003743-00220*
*suspended
">, 0-dimethyl S-((4-oxo-l, 2, 3-benzotriazin-3( 4H)-yl)methyl) phosphoro-
dithtoate (058001), endrin (041601) plus xylene (086802)
005905-00203
0,0-dimethyl S-((4-oxo-l, 2, 3-benzotriazin-3(4H)-yl)methyl) phosphoro-
iithioate (058001). endrin (041601) plus xylene range aromatic solvent
086803)
:• 35905-00358
. • ib/gal emulsifiable concentrate
•.-,0-diraethyl S-( ( 4-oxo-l, 2, 3-benzotriazin-3( 4H)-yl)methyl) phosphoro-
3 \ihi3ate (058001) plus aromatic petroleum distillate (006601)
uC3125-00185
. • :2i emulsifiable concentrate
",0—Jimethyl S-((4-oxo-l,2,3-benzotriazin— 3(4H)-yl)methyl) phosphoro-
:-:hibate (058001)
309359-00270 011163-00030 046007-00008
•'., C-dimethyl S-( ( 4-oxo-l, 2, 3-benzotriazin-3( 4H)-yl)methyl) phosphoro-
dithioate (058001) plus aromatic petroleum distillate (006601)
002749-00235 003125-00102 003125-00123 003125-00194
. emulsifiable concentrate
?,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001), aromatic petroleum derivative solvent (006501),
eihylene dichloride -(042003) plus petroleum distillate (063503)
00°222-00043
12. 37°: emulsifiable concentrate
0,0-dimethyl S-<(4-oxo-l,2,3-benzotriazin-3(4H)-yl)raethyl) phosphoro-
dithioate (058001) plus xylene (086802)
005797-00104*
* suspended
_2 Ib/gal flowable concentrate-
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (053001)
003125-00337
Issued: 2-28-85 IIT-058001-44
-------
EPA Compendium of-Acceptable Uses-
0,0-DIKETHYL S-(( 4-0X0-1, 2, 3-BENZOTRIAZIN-3( 4H)-YL-) -
METHTL) PHOSPHORODITHIOATE
Listing of Registered Pesticide Products by-Formulation (continued)
0014 3' Ib/gal flowable concentrate
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001)
003125-00338
4015 12.41 soluble concentrate/liquid
0,0-dimethyl S-((4-oxo-l,2,3-benzotriazin-3(4H)-yl)methyl) phosphoro-
dithioate (058001) plus xylene (086802)
007764-00030
399
State Label Registrations
AL Reg. No.
015575-05336
AZ Reg. Mo.
002935-06569
010163-06396
CA Reg. Mo.
000279-0399 3
010965-10008
FL Reg. "No.
014775-10499
003125-07852
010965-10009
007001-07773 010965-09871
010972-08689
LA Res. No.
NJ Reg. No.
005131-06786
OR Reg. No.
001871-08950
WA Reg. No.
003125-07826
005131-06737
001871-08964
014782-10330 014782-10337
003125-07858
Issued: 2-2S-85
111-058001-45
-------
196
EPA Compendium of Acceptable Uses
0,0-DIHETHYL S-( ( 4-0X0-1 , 2, 3-BENZOTRIA2DI-3( 4H)-YL)-
METHY1) PHOSPHORODITHIOATE
Appendix A
Listing of Common Chemical Names Used on Che Entry
Common Name EPA Acceptable
(source) Common/ Chemical Name
053501 m parathlon 0, 0-dimethyl 0-p-nitrophenyl phosphorothioate
077501 sulfur ic -, u
Uv sulfur or sulphur
Issued: 2-28-85 111-058001-46
-------
197
BIBGUIDE-1
GUIDE TO USE OF THIS BIBLIOGRAPHY.
CONTENT OF BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA in
arriving at the positions and conclusions stated elsewhere-
in the Standard. Primary sources for studies in this
bibliography have been the body of. data submitted to EPA
and its predecessor agencies in support ot past regulatory
decisions. Selections from other sources including the
published literature, in those instances where they have
been considered, will be included.
UNITS OF ENTRY. The unit of entry in this bibliography
is called a "study." In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to- the Agency, the Agency
has sought to identify documents at a level parallel to
the published article from within the typically larger
volumes in which they were submitted. The resulting
"studies" generally have a distinct title (or at least a
single subject), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has attempted also to unite basic
documents and commentaries upon them, treating them as a
a ingle study .
IDENTIFICATION OF ENTRIES. The entries in this bibliography
are sorted numerically by "Master Record Identifier," or
MRID, number. This' number is unique to the citation, and
-hcul- be used = c any -iir.e specific reference is required.
It is noc rexacaa co c.ie six-digic 'Accession Numcer;'
which has been used to identify volumes of submitted
studies; see paragraph 4(d)(4) below for a further explana-
tion. In a few cases, entries added to the bibliography
late in the review may be preceded by a nine-character
temporary identifier. These entries are listed after
all MP.ID ^ntri as. This' temporary identifier number is
also to be used whenever specific reference,is .needed.
FORM OF ENTRY. In addition to the Master Record Identifier
(MRID), each entry consists of a citation containing
standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known
submission. Bibliographic conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
-------
198
BIBGUIDE-Z
a- Author. Whenever the Agency could confidently identify
one, the Agency has- chosen to show a personal author.
When no individual, was identified, the Agency has
shown an identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
b. Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four-digit date is followed
by a question mark, the bibliographer deduced the
date .from evidence in the document. When the date
appears as (19??), the Agency was unable to determine
or estimate the date of the document.
c. Title. In some cases, it has been necessary for
Agency bibliographers to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
d. Trailing Parentheses. For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any self-explanatory text) the fol-
lowing elements describing the earliest known submission:
CD Submission Date. The date' of the earliest known
submission appears immediately following the word
"received."
(2) Administrative Number. The .next element,
immediately following the word "under," is the
** ° o * ~^"^^^"ion ^';rnbt-^r -'xoerimentai use o e -—n.iz
numoer, pecizion numoer, or otner adminio^racive
number associated with the earliest known submission
(3) Submitter. The third element is the submitter,
following the phrase "submitted by." When
authorship is defaulted to the submitter, this
element is omitted.
(4) Volume Identification (Accession Numbers). The
final element, in the trailing parentheses
identifies the EPA accession number of the volume
in which the original submission of the study
appears. The six-digit accession number follows
the symbol "COL," standing for "Company Data
Library." This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123456, the
first study would be 123456-A; the second, 123456-
B; the 26th, 123456-Z; and the 27th, 123456-AA.
-------
199
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Azinphos methyl Standard
MR ID CITATION
00029078 Nichols, S.S.; Becker, B.D.; Morris, R.A. (1979) Addition to. Syn-
opsis of Residue Chemistry on Cotton (Guthion plus DEF). (Un-
published study received Feb 26, 1980 under 3125-102; prepared
in cooperation with Chemonics Industries and others, submitted
by Mobay Chemical Corp., Kansas City, Mo.; CDL:241846-A)
00029885 Atwell , S.; Close, C. (1976) Leaching Characteristics of Gu-
thion on Aged Soil: Report No. 48466. (Unpublished study re-
ceived Jan 28, 1980 under 5F1547; submitted by Mobay Chemical
Corp.., Pittsburgh, Pa.; CDL:099216-F)
00029887 Thornton, J.S.; Hurley, J.B.; Obrist, J.J. (1976) Soil Thin-Layer
Mobility of Twenty Four Pesticides [sic] Chemicals: Report
No. 51016. (Unpublished study received Jan. 28, 1980 under
5F1547; submitted by Mobay Chemical Corp., Pittsburgh, Pa.; COL:
099216-1)
00029899 Wllkes, L.C.; Wargo, J.P.; Gronberg, R.R.; et al . (1979) Dissi-
• • pation of Guthion in Aqueous Solution: Report No. 67983.
(Unpublished study received Jan 28, 1980 under 5F1547; prepared
in cooperation with Analytical Development Corp., submitted by
Mobay Chemical Corp., Pittsburgh, Pa.; COL:099216-U)
00029900 Gronberg, R.R.; Pollock, R.J.; Wargo, J.P. (1979) The Metabolism
of lucr.-ion in Sandy Loam Soil: Report No. 68030. (Unpub-
iisnea :^jay ~3C3!vea ^an 13, ".380 jncsr 5FI547; pr°oar=d in co-
operation with Analytical Development Corp., submitted by Mooay
Chemical Corp., Pittsburgh, Pa.; CDL:099216-V)
00030303 Wargo, J.P.; Pollock, R.J.; Gronberg, R.R.; et al . (1978) Deter-
mination of Guthion and Guthion Oxygen Analog in Bovine
Tissues and Milk. Includes method no. 664-39 dated Apr 10,
1978 and method no. 66441 dated Jun 29, 1978. (Unpublished
study including report nos. 66440, 66442, 66446..., received
Jan 28, 1980 under 5F1547; prepared in cooperation with Analyti-
cal Development Corp., submitted by Mobay Chemical- Corp., Kansas
City, Mo.; CDL:099213-8)
00034769 Hill, E.F.; Heath, R.G.; Spann, J.W.; et al . (1975) Lethal Dietary
Toxicities of Environmental Pollutants to Birds. By U.S. Fish
and Wildlife Service, Patuxent Wildlife Research Center. Wash-
ington, D.C.: U.S. FWS. (Special Scientific Report —Wi Idl i re
No. 191; report no. 33423a; also in unpublished submission re-
ceived Mar 28, 1979 under 3125-236; submitted by Mobay Chemical
Corp., Kansas City, Mo.; COL:237905-8)
-------
200
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations. Considered to be Part of. the Data Base Supporting
Registration's Under the Azinphos- methyl- Standard
MR ID CITATION
00035890 Dorough, H.W.; Randolph, N.M. (1967) Comparative Residual Nature of
certain Insecticides Applied as Low Volume Concentrate and Water
Emulsion Sprays. Bulletin of Environmental Cbntaimi'nation &
Toxicology 2(6) :340-342. (Also in unpublished submission re-
ceived Apr 1, 1969 under 241-219; submitted by American Cyanamid
Co., Princeton, N.J.; CDL:002059-F)
00045038 Holt, B.E.; Thomas, J.; Olney, V.W.; et al . (1977). Residue Report:
Cottonseed: Curacron 4EC + Azinphosmethyl: AG-A No. 4372. (Un-
published study including AG-A nos. 4423 and 4466 I, II, re-
ceived Jun 1, 1977 under 100-EX-53; submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:096930-0)
00066220 Atkins, E.L., Jr.; Anderson, L.D.; Kelt urn, D.; et al . (1976)
Protecting Honey Bees from Pesticides. ?: Univ. of California,
Div. of Agricultural Sciences. (Leaflet 2883; also in unpub-
lished submission received Mar 20, 1980 under 432-502; sub-
mitted by Penick Corp., Lyndhurst, N-.J.; CDL:243536-8)
00067*94 Cnemagro Corooration (1962) Recovery of Guthion from Dry Alfalfa:
Report No-. 9493. (Unpuolisned study received Jun 9, 1964 under
PP0367; submitted by Mobay Chemical Corp., Kansas City, Mo.;
CDL:090396-8)
?C07Q'-92 c;hev, J.Z.: 31 ickenstaff, C.O. M.960) Residues of diazinon,
gutmon, neptacnior, and sevin on mixed pasture grass. Pagas
33-34 only, in Proceedings, North Centrol Branch-E.S.A.:
Vol. XV. (Also in unpublished submission received Dec 16, 1980
under 100-461; submitted by Oregon, Dept. of Agriculture under
OR 80/62 for Ciba-Geigy Corp., Greensboro, N.C.; CDL:243998-0)
00080102 Mobay Chemical Corporation (1979) Recovery Data for Guthion and
Galecron from-Cotton. (Compilation; unpublished study, i-nclud-
ing 68143, 68144, 68256..., received Aug 21, 1981 under 12561;
CDL:070234-0)
00080143 Mobay Chemical Corporation (1981) Synopsis of Guthion: Residue
Chemistry on Various Crops. Summary of studies 245794-8 and
245794-C. (Unpublished study received Aug 4, 1981 under 3125-
337; CDL:245794-A)
00080144 Westburg, G.L.; Becker, B.O. (1981) Gas Chromatographic Method
for Determination of Guthion Residues: Submitter 69523.
Method dated Feb 13, 1981. (Unpublished study received Aug 4,
1981 under 3125-337; submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:245794-8)
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201
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Azinphos methyl Standard
MR ID CITATION
00083620 Noel, P.R.B.; Mawdesley-Thomas, I.E.; Cozens, D.; et al . (1966)
Gusathion (Bayer 17'147) Chronic Oral Toxicity Study in Dogs:
1656/66/184; 19798. Final rept. (Unpublished study received
Apr 7, 1970 under OF0869; prepared by Huntingdon Research Cen-
tre, England, submitted by Mobay Chemical Corp., Kansas City,
Mo.;. COL:091498-AI)
00087511 Mobay Chemical Corporation (1978) Bolstar and Guthion Residue-
-Cotton. (Compilation; unpublished study, including 51177,
51191, 52624, .... Deceived Mar 13, 1978 under 3125-321;
CDL:096914-G)
00087512 Analytical Biochemistry Laboratories (1977) Recovery of Guth-
ion from Various Crops: Submitter 51969. (Unpublished study
received Mar 13, 1978 under 3125-321; submitted by Mobay Chem-
ical Corp., Kansas City, Mo.; CDL:096914-H)
00089642 Mobay Chemical Corporation (1960) Synopsis of Analytical and Resi-
due Data for Guthion in Grapes. (Compilation-; unpublished study
received May 12, 1960 under PP0249; CDL:090276-A)'
00089740 Mobay Chemical Corporation (1961) Synopsis of Analytical, Residue,
and Flavor Evaluation Data for Guthion on Artichokes, Green
Beans, Blueberries, Cranberries, Currants, Filberts, Spinach,
and 'omatces. Includes methods dated Feb 14, 1958 and Jan 1,
1961. ;CompiI at ion ; unpuoiisned study received ,1ay 12, 1961
under PP0314; CDL:090333-A; 090334)
00089890 Mobay Chemical Corporation (1961) Guthion: Analytical, Residue, and
Taste Data on Blackberries, Boysenberries, Loganberries and
Raspberries. Includes method dated Sep 1, 1961. (Compilation;
unpublished study study received on unknown date under PPQ336;
CDL:'090364-8)
00090126 Mobay Chemical Corporation (1962) Synopsis of Analytical and Resi-
due Information on Guthion (Citrus). (Compilation; unpublished
study received Mar 30, 1962 under PP0355; CDL:090383-A)
00090127 Mobay Chemical Corporation (1962) Synopsis of Analytical arid Resi-
due Information on Guthion (Brussels Sprouts). (Compilation;
unpublished study received Mar 30, 1962 under PP0355; CDL:
. 090383-8)
00090273 Mobay Chemical Corporation (1961) Study of Guthion Residue in
Animal Tissue, Milk, and Plant Materials. Includes methods
dated Dec 1, 1961, Jan 1, 1961 and Dec 6, 1961. (Compilation;
unpublished study received Feb 1, 1962 under PP0336; CDL:
090365-A)
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202
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to- be Parr of the Data- Base Supporting
Registrations Under the- Azinphos methyl Standard
MR ID • CITATION
00090274 Loeffler, W. (1961) Guthion in Milk: Report No. 6924. Includes
method dated Jan 16, 1961. (Unpublished study received Feb 1,
1962 under PP0336; submitted by Mobay Chemical Corp... Kansas
City, Mo.; CDL:090365-8)
00090275 Everett, L.J. (1961) Metabolism of P32 Labeled Guthion in a Dairy
Cow: Report No. 7391. (Unpublished study received Feb 1,
1962 under PP0336; submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:090365-E)
00090276 Everett, L.J. (1961) Studies on the Nature of Guthion Metabolites
in Milk Following Oral Administration to Cattle: Report
No. 7392. Includes method dated Oct 6, 1961. (Unpublished
study received Feb 1, 1962 under PP0036; submitted by Mobay
Chemical Corp., Kansas City, Mo.; CDL:090365-F)
00090277 Adams, J.M. (1961) Application of the Photofluorometric Method
Developed for the Determination of Guthion Residues to the
Determination of Residues of Certain Benzazimide Moieties of
. .. Guthion: 'Report No. 7407. (Unpublished study received Feb 1,
1962 under PPQ326; submitted by Mobay Chemical Corp., Kansas
-City, Mo.; CDL:090365-G)
00090278 Everett, L.J. (1961) Metabolism of C14 Labeled Guthion in a Dairy
Cow: Report No. 7559. (Unpublished study received Feb 1,
196Z -near -or]22rJ \ suQmi~~ec 3y ^obay ~!iemica> ^jrT., ^ansas
City, Mo.; CDL:090365-H)
00090279 Anderson, C.A. (1962) The Effect of Zinc Reduction on the Recovery
of Guthion from Raspberries: Report No. 8272. Rev. (Unpub-
lished study received Feb 1, 1962 under PP0336; submitted by
Mobay Chemical Corp., Kansas City, Mo.; CDL:090365-J)
00090280 Mobay. Chemical -Corporation (1962) Supplement "to Synopsis of Guthion
in Forage Legumes: Supplement No. 1. (Compilation; unpublished
study received Feb 1, 1962 under PP0336; COL:090365-K)
00090946 Mobay Chemical Corporation (1964) Guthion Residue—Peas and
Beans. (Compilation; unpublished study, including report nos.
13,434, 13,435, 13,436, .... received Oct 14, 1966 under 7F0539;
CDL:090659-I)
00091562 Mobay Chemical Corporation (1965) Determination of Guthion Res-
idues in Crops and Soils. (Compilation; unpublished study re-
ceived Feb 19, 1965 under 5FQ442; CDL:090482-A)
-------
203
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Azinphos methyl Standard
MRID CITATION
00093570 Mobay Chemical Corporation (1964) Synopsis of Analytical and Resi-
due Data on Guthion (Barley, Oats, and Wheat). (Compilation;
unpublished study, including published data, received Jan 3,
1968 under 7F0582; CDL:090746-8)
00093572 Mobay Chemical Corporation (1967) Residue Experiments with Guthion
on Various Grains and Straws. Includes method dated Apr 7,
1967. (Compilation; unpublished study, including report nos.
21,168, 21,169, 21,170 .... received Jan 3, 1968 under 7F0582;
CDL:090746-0)
00098957 Newby, L. (1973) A Summary Report of Analytical Data Obtained fol-
lowing Multiple Applications of Galecron/Fundal in Tank Mix Com-
bination with Guthion Methyl Parathion and Methyl Parathion-tox-
aphene to Cotton: Report No. GAAC-73003. (Unpublished study re-
ceived Jan 17, 1973 under 2139-98; prepared by Ciba-Geigy Corp.,
submitted by Nor-Am Agricultural Products, Inc., Naperville, IL;
CDL:008176-8) ,
0010032-1 Mooay Chemical Corp. '1957) Residue Studies of Guthion on Various
.-:. •.•— Fruits. (Compilation; unpublished study received on unknown
date under PP0115; CDL:090144-W)
00100825 Metcalf, 9. (1957) Translocation of Guthion in Cotton: Submitter
-15'-5. 'Jnouo i ' sned study ~=caived on -jnxnown aata under
PP0115; prepared by Univ. of Cal i fornia—Riverside, Dept. of
Entomology, submitted by Mobay Chemical Corp., Kansas City, MO;
CDL:090144-Y)
00102272 Mobay Chemical Corp. (1956) Residue Studies of Guthion on Cot-
ton. (Compilation; unpublished study received Jan 2, 1957
under PP0115; CDL:090144-B)
00102299 Mobay Chemical Corp. (1974) Guthion Analytical and Residue Informa-
tion on Cotton: Supplement No. 2. (Compilation; unpublished
study received Aug 9, 1974 under 3125-271; CDL:009691-C)
00106832 Mobay Chemical Corp, (1971) Guthion Analytical and Residue Informa-
tion (Citrus Fruit). (Compilation; unpublished study received
Aug 17, 1971 under 3125-25; CDL:006340-A)
00107018 Mobay Chemical Corp. (1966) Guthion: Residues in Various Crops
and Soil. (Compilation; unpublished study received Aug 11,
1966 under 7F0539; CDL:090656-A)
00107019 Mobay Chemical Corp. (1965) Guthion: Residues in Various Vegeta-
bles and Soil. (Compilation; unpublished study received Mar
19, 1965 under 7FG539; COL:090657-A)
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204
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Az.inphos methyl Standard
MR ID CITATION
00107020 Mobay Chemical Corp. (1963) Guthion: Residues in Melons, Peppers,
and Soybeans. (Compilation; unpublished study received Aug 11,
1966 under 7F0539; CDL:090658-A)
00109278 Mobay Chemical Corp. (1966) Analysis of Guthion Spraying of Al-
monds. (Compilation; unpublished study received Jun 25, 1982
under 3125-301; CDL:247904-A)
00112024 Mobay Chemical Corp. (1967) Guthion: Analytical and Residue Infor-
mation on Sugarcane. (Compilation; unpublished study received
Jul 20. 1967 under 3125-102; CDL:006943-A)
00112026 Mobay Chemical Corp. (1967) Guthion: Analytical and Residue Infor-
mation on Sugarcane. (Compilation; unpublished study received
Feb 14, 1967 under 3125-102; CDL:007007-A)
00112027 Mobay Chemical Corp. (1967) Residues of Guthion in Cotton.
(Compilation; unpublished study received Apr 13, 1967 under
3125-102; CDL: 007008-A)
00112035 Mobay Chemical Corp. (1963) Study of Guthion Residue on Specified
Crops. (Compilation; unpublished study received Feo 28, 1964
•••'• " ".under 3125-138; COL:050498-8)
00112037 Mobay Chemical Corp. (1971) Guthion: Analytical and Residue Infor-
mation 'Citrus --'jit^. < Comoil ation ; unpublished study Deceived
Aug i7, .371 .jnaer PP0355; CCL.090334-A/
00112039 Mobay Chemical Corp. (1967) Guthion M-E: Analytical and Residue
Information on Soybeans. (Compilation; unpublished study re-
ceived Nov 5, 1967 under 8F0653; CDL:091140-A)
00112052 Mobay Chemical Corp. (1969) Guthion Analytica-1 and Residue In-
formation: Beans, Cowpeas , Soybeans & Nut Crops. (Compilation;
unpublished study received Apr 8, 1970 under OF0869; CDL:
091501-A; 091499)
00112053 Mobay Chemical Corp. (1968) Guthion: Analytical and Residue In-
formation (Potatoes). (Compilation; unpublished study received
Apr 8, 1970 under OF0869; CDL:091500-A)
00112054 Mobay Chemical Corp. (1969) Guthion M-E: Metabolic, Analytical,
and Residue Information on Cotton. (Compilation; unpublished
study received Jun 14, 1970 under OF0934; CDL:091594-A)
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205
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Azinphos methyl Standard
MR ID CITATION
00112071 Meagher, W. (1956) The Effect of Processing on Guthion Content of
Cottonseed: 20428. (Unpublished study received May 10, 1967
under 7F0539; submitted by Chemagro Corp., Kansas City, MO;
CDL:098609-A)
00112072 Mobay Chemical Corp. (1978) Guthion: Residues in Kiwi fruit.
(Compilation of reports by various government agencies; unpub-
lished study; CDL:097294-A)
00112073 Mobay Chemical Corp. (1977) Azinphosmethyl Insecticide Residue
Tolerance Petition—Moss-curled and Root Parsley. (Compilation;
unpublished study received Jul 16, 1979 under 3125-123; CDL:
098397-A)
00112074 Interregional Research Project No. 4 (1978) Results of Tests Con-
cerning the Amount of Azinphosmethyl Residue Remaining in or
on Pistachios, Including a Description of the Analytical Method
Used. (Compilation; unpublished study received Sep 18, 1978
under 8E2125; COL:098328-A)
00112078 Mobay Chemical Corp. (1961) Residues of Guthion in Cranberries
ana Otner Crops. ^Compilation; unpublished stuay receivea
May 12, 1961 under PP0314; COL:092595-A)
00112083 Mobay Chemical Corp. (1963) Guthion: Analytical and Residue Inform-
ation on Sugar Cane. (Comoilation; unpublished study received
-ID 19, .'.-65 Jncer 5F04^2; :3L:092731-A)
00112086 Mobay Chemical Corp. (1967) Study: Guthion Residue in Soybean Oil,
and in Cottonseed. (Compilation; unpublished study received
May 8, 1967 under 7F0539; CDL:092827-A)
00112093 Chemagro Corp. (1961) Method for Pesticide Guthion on Grapes ...
00-Dimethyl S-(4-oxo-l,2,3-benzotriazinyl-3--methyl) phosphoro-
dithioate. (Unpublished study received on unknown date under
PP0249; CDL:098724-A)
00112108 Mobay Chemical Corp. (1961) Guthion: Analytical and Residue Data
on Grapes. (Compilation; unpublished study received Oct 23,
1961 under unknown admin, no.; CDL:119915-A)
00112110 Mobay Chemical Corp. (1962) Guthion: Analytical and Residue Data--
Cottonseed. (Compilation; unpublished study received Jun 19,
1962 under unknown admin, no.; COL:119917-A)
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206
.. . REGISTRATION STANDARD BIBLI-OGRAPh'Y
CitationsConsidered- to be Part of the Data Base Supporting
Registrations Under the Azinphos methyl Standard
MRID 'CITATION
00112111 Mobay Chemical Corp. (1965) Guthion: Analytical and Residue In-
formation on Cucumbers and Dry Onions. (-Compilation; unpub-
lished study received Apr 9, 1965 under unknown admin, no.;
CDL:119918-A)
00112112 Mobay Chemical Corp. (1956) Guthion: Analytical and Residue Data-
Cotton. (Compilation; unpublished study received Nov 5, 1956
under unknown admin, no.; CDL:119955-A)
00112113 Mobay Chemical Corp. (1969) Guthion: Residues in Apples. (Com-
pilation; unpublished study received Jan 20, 1970 under 3125-25;
CDL:119956-A)
00112114 Mobay Chemical Corp. (1966) Guthion: Analytical and Residue In-
formation on Cotton. (Compilation;, unpublished study received
Mar 28, 1966 under unknown admin, no.; CDL:119957-A)
00112115 Mobay Chemical Corp. (1966) Supplement No. 1 to Brochure Entitled:
Guthiun; Analytical Information on Sugarcane. (Compilation;
unpublished study received Mar 20, 1966 under'3125-132; CDL:
119958-A1)
00112116:.Mobay Chemical Corp.. (1962) Guthion: Analytical and Residue Data--
Broccoli, Brussels Sprouts, Cabbage, and Cauliflower. (Compi-
lation; unpublished study received Apr 11, 1962 under unknown
admin._no. ; CDL: 119959-A)
00112117 Mobay Chemical Corp. (1963) Guthion: Analytical and Residue In-
formation on Filberts. (Compilation; unpublished study re-
ceived Jun 10, 1963 under unknown admin, no.; CDL:119960-A)
00112120 Mobay Chemical Corp. (1968) Guthion: Analytical and Residue In-
formation (Tomatoes). (Compilation; unpub>ished study received
Oct.7, 1968 under 3125-25; CDL:119986-A)
00112126 Mobay Chemical Corp. (1965) Residues of Guthion in Pecans and
Other Crops. (Compilation; unpublished study received 1965
under 3125-EX-91; COL:126956-B)
00112137.Mobay Chemical Corp. (1975) Residues of Guthion in Apples.
(Compilation; unpublished study received' Jul 15, 1975 under
3125-123; COL:195012-A)
00112139 Mobay Chemical Corp. (1974) Residues of Guthion in Oranges and
Other Crops. (Compilation; unpublished study received Mar 26,
1975 under 3125-25; COL:195018-A)
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207
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Azinphos methyl Standard
MR ID CITATION
00112142 Mobay Chemical Carp. (1965) Guthion: Analytical and Residue Infor-
mation — Caneberr-ies.. (Compilation; unpublished study received
Mar 22, 1965 under 3125-25; CDL:223870-A)
00112143 Mobay Chemical Corp. (1963) Guthion: Analytical and Residue Data-
Blueberries, Grapes, and Oranges. (Compilation; unpublished
study received Jan 28, 1964 under 3125-25; CDL:223871-A)
00112145 Mobay Chemical Corp. (1976) Guthion: Residue Chemistry on Various
Crops: AS76-790. (Compilation; unpublished study received Jun
29, 1976 under 3125-25; CDL:224702-A)
00112146 Mobay Chemical Corp. (1976) Guthion: The Effects on the Environ-
ment — Environmental Chemistry: AS76-791. '• (Compilation; unpub-
lished study received Jun 29, 1976 under 3125-25; CDL:224703-A)
00112151 Mobay Chemical Corp. (1978) Guthion: Residue Chemistry on Melons,
Peppers and Soybeans: Addition No. 1 to Brochure Entitled:
Guthion: Analytical and Residue Data (Melons, Peppers and Soy-
beans): AS78-1365. (Compilation; unpublished study received
26, 1978 under 3125-102; CDL:234239.-A)
00112159 Mobay Chemical Corp. (1979) Gutnion Residue Chemistry on Almonds —
Addition No. 2: To Brochure Entitled— Guthion Analytical and
Residue Information on Almonds: AS79-1499. (Compilation; unpub
lished study received Jul 26, 1979 under 3125-301; CDL:238898-A)
JJ11775G /loo ay J^emcii Corp. , ,}~l'/ Gutmon: Analytical and Residue Inror-
mation (Grass). (Compilation; unpublished study received May 2,
1971 under 1F1166; CDL:090960-A)
00141541 Mobay Chemical Corp. (1983) Addition No. 2 (Cotton): Brochure No.
1217 to the Brochure Entitled: Guthion: Res-idue Chemistry on
Vari6us Crops (Dated July 9, 1981). Unpublished compilation.
43 p.
00143785 Forbis, A.; Burgess, D.; Franklin. L. ; et al . (1984) Chronic Toxi-
city of [Carbon 14]-Guthion to Daphni'a magna under Flow-through
Test Conditions: Final Report: 131802. Unpublished study pre-
pared by Analytical Biochemistry Laboratories. Inc. 226 p.
00144667 Morris, R. (1979) Soil Persistence Study: HFI-763-77/79D. Unpub-
lished Mobay study No. 57803 prepared by Analytical Development
Corp. 29 p.
00144669 Morris, R. (1979) Soil Persistence Study : RGV-761-77/79D. Unpub-
lished Mobay Study No. 67805 prepared by Analytical Development
Corp. 41 p.
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208
REGISTRATION STANDARD BIBLIOGRAPHY ,
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Azinphos methyl Standard
MRIfJ CITATION
00144673 Morris, R. (1979) Soil Persistence Study: RGV-751-77/79D. Unpub-
lished Mobay study no. 67809 prepared by Analytical Development
Corp. 40 p.
00145591 Lamb, D. (1980) Azinphos-methyl (Guthion) Technical Acute Toxicity
to Daphnia magna: Toxicology Report No. 91; Mobay Report No.
68678. Unpublished study prepared by Mobay Chemical Corp. ,9 p.
00145592 Carlisle, J. (1985) Toxicity of Azinphos-methyl (Guthion Technical)
to Rainbow Trout Early Life Stages: Study Number 84-666-02: Tox-
icology Report No. 578: Unpublished study prepared by Mobay
Chemical Co. 17 p.
00154989 Mobay Chemical Corporation (1982) [Residue Data for GUTHION]. Un-
published compilation. 656 p.
00154992 Nelson,D. (1978) Acute Toxicity of Guthion 2S to Bluegill and Rain-
bow Trout: Report No. 66046. Unpublished study prepared by
Mobay Chemical Corp. 5 p.
001549-96" Mobay Chemical Corporation (1981) GUTHION Residue Chemistry on
Tomatoes: Addition No. 1 to Brochure Entitled: GUTHION Analyti-
cal and Residue Information (Tomatoes). Unpublished compila-
tion. 28 p.
00155000 Crawford, C.; Anderson, R. (1974) The Acute Oral Toxicity of Guth-
~on ~-BC.ini cal , 3en232im-ide and" Methyl Senzazimide :o Rats: Re-
port No. 41190. u'npuDlisnea study prepared by Cnemagro Agri-
cultural Division of Mobay Chemical Corporation. 3 p.
00155001 Lamb, D.; Anderson, R. (1974) The Acute Oral Toxicity of GUTHION,
Benzazimide and Methyl Benzazimide to Fasted and Nonfasted Rats
Using CMC a 2 the Excipient: Report No. 41621. Unpublished study
prepared by Chemagro Agricultural Division-of Mobay Chemical
Corporation. 5 p.
00155002 Mihail, F. (1978) R- 1582 (Gusathion M Active Ingredient): Acute
Toxicity Studies: Report No. 7618. Unpublished study prepared
by Farbenwerke Bayer AG Institute of Toxicology. 8 p.
00155003 Heimann, K. (1982) R 1582 (Azinphos-methyl , the Active Ingredient
of GUTHION): Study of the Acute Oral and Dermal Toxicity to
Rats. Unpublisned study prepared by Fardenwerke Bayer AG Insti-
tute of Toxicology. 6 p.
nm^Oll Kimmerle, G. (1976) Subchronic inhalation toxicity of azinphos-
methyl in rats. Arch. Toxicol. 35:83-89.
-------
209
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Azinphos methyl Standard
MR ID CITATION
00155017 Myhr, B. (1983) Evaluation of 1582 C.M. Azinphos-methyl in the Pri-
mary Rat Hepatocyte. Unscheduled DNA Synthesis Assay: Final Re-
port: LBI Proj. No. 20991. Unpublished study prepared by Litton
Bionetics. 14 p.
00155019 Patzschke, K.; Wegner, L.; Weber, H. (1977) [Carbon-14]-Azinphos-
methyl ([Carbon-14]-GUTHION) Biokinetics Studies on Rats: PH-
Report No. 6419. Unpublished study prepared by Farbenwerke
Bayer AG Institute of Toxicology. 34 p.
00155020 Scheele, B.; Fuhr, F.; Krampitz, G. (1977) Studies on the conver-
sion and metabolism of carbonyl-[carbon-14]-labeled azinphos-
methyl i;n poultry. Landwirtsch. Forsch. 30(1):56-68.
00155026 Steffens, W.; Wieneke, J. (1976) Studies on the uptake, metabolism
and degradation of [carbon-14]-label led gusathion in kidney
beans: I. Extraction, fractionation and [carbon-14] balance.
Pfl anzenschutz-Nachrichten 29(1):1-17.
0015502.1 Ecker, W. (1976) [Carbon-14] Azi nphosmethyl, Metabolism Studies on
• -.- Rats; "Preliminary Results: Pharma Report No* 6106. Unpublished
study prepared by Farbenwerke Bayer AG Institute of Toxicology.
, .. ..24 p.
00155064 Mobay Chemical Corporation (1982) [Residue Data for GUTHION]. Un-
published compilation. 677 p.
00155065 wiene.Ke, u,; Siieffens, n'. (1976) Studies on trie uptake, necaooiism
and degradation of [carbon-14]-labelled gusathion in kidney
beans: II. Separation and identification of metabolites. Pflan-
zenschutz-Nachrichten 29(1):18-34.
OG158905 Root, D. (1962) Letter sent to Chief Chemist, Minneapolis District
dated Apr 30, 1962: Pesticide petition #336-: Guthion: [Residue
data on berries]. Prepared by United States Goyt. 5 p.
00158906 Sabatino, F. (1962) Letter sent to Bureau of Field Administration.
dated Jun 6, 1962: Pesticide petition 336: Guthion: [Residue
data on raspberries]. Prepared by United. States Govt. 9 p.
00158908 Mobay Chemical Corp. (1981) Guthion Residue Chemistry on Almonds:
Addition No. 3 to Brochure Entitled: Guthion Analytical and
Residue Information on Almonds (Dated February 1, 1967). Unpub-
lished compilation prepared in cooperation with Morse Labo-
ratories. 93 p.
00158909 Love, J.; cerguson, A. (1976) Pesticide residues and greedy scale
control on kiwi fruit. N.Z. Journal of Agricultural Researcn
20:95-103.
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210
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the'Azinphos methyl Standard
MR ID CITATION
05004211 Bowman. M.C.; Beroza, M. (1967) Temperature-programmed gas
chromatography of 20 phosphorus-containing insecticides on 4
different columns and its application to the analysis of milk
and corn silage. Journal of the Association of Official
Analytical Chemists 50(6):1228-1236.
GS0235-005 US Environmental Protection Agency (1977) Report on Toxicity of
Guthion (50% WP) to Rainbow Trout: Static Jar Test #1088.
Unpublished study prepared by Chemical and Biological Invest-
igations Branch. 10 p.
GS0235-008 Al-Adil, K; White, E; et al. (1973) Uptake and Translocation of
Guthion by Beans and Barley. J. Agr. Food Chem., 21(3):
376-379.
GS0235-014 Adams, J; Anderson, C. (1966) Spectrophotofluorometric Method
for Guthion Residues in Milk and Animal Tissues, J. Agr.
Food Chem._: 14(3) -53-55,
GS0235-0.15 Anderson, C. (1958) Colerimetric Determination of Guthion III
Tentative Method for Aoplication to Milk. Unpublished
study prepared by Chemagro Corp., Research Department. 5 p.
GS0235-055 National Cancer Institute (1978) Bioassay of Azinphosmethyl for
Possible Carcinogenicity: Technical Report No. 69. 126 o.
t5G235-057 "ranxiin, C; Fensxe, R.; Greennalgn, R.; et ai. (1981) Correlation
of Urinary Pesticide Metabolite Excretion with Estimated
Dermal Contact in the Course of Occupational Exposure to
Guthion. Journal of Toxicology and Environmental Health (7):
715-731.
GS0235-101 Stevenson, J.; (1968) Laboratory Studies on the Acute Contact
and Oral Toxicities of Insecticides to Honeybees. Ann.
appl. Biol . 61, 467-472.
&S0144-012 Johnson, W. ; Finley, M. (1980) Handbook of Acute Toxicity of
Chemicals to fish and Aquatic Invertebrates. USDI Publication
137, Washington, D.C.
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211
OMB Aoonval No. 200O-0463 /Expires 12-31-33)
F1FHA SECTION 3(C)(2)(B> SUMMARY SHEET
EPA REGISTRATION NO.
PRODUCT NAME
APPLICANT'S NAME
DATE GUIDANCE DOCUMENT ISSUED
With respect to the requirement to submit "generic" data imposed by the FIFHA action 3(C)(23(B) notice contained in the retwancsd
Guidance Document, I am responding in the following manner
1. I will submit data in a timely manner to satisfy the following requirement!. If the test procedures I will use deviate from (or are not
specified in) the Registration Guidelines or the Protocols contained in the Reports of Expert Groups to the Chemicals Group, OECO
Chemicals Testing Programme, I enclose the protocols that I will use:
O 2. I have entered into an agreement with one or more other registrants under FIFflA section 3(CJ(2!(B)(ii) to satisfy the following data
requirements. The lasts, and any required protocols, will be submitted to EPA by:
NAME OF OTHER REGISTRANT
LJ 3. I inclose i completed "Cartrtication ot Attempt tn enter Into an. Agreement with Other Registrant) for Development of Data" with
rasped to the following can requirements:
_ ». i raquat :7,3t you smsna mv 'filtration oy caming mi tallowing uan itnis action a nni
to aaoncami ror new oraauciu:
U 5. I request voluntary canealUtion of the ragistration of this product. (This option is not available to applicants for new products.)
REGISTRANTS AUTHORIZED REPRESENTATIVE
SIGNATURE
DATE
£?A F-orm 8S8O-1 (10-32J
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212
OMB Aooroval No. 20OOO463 (Exoinx: 12-31-331
qualify, certify ALl^ four items)
CERTIFICATION OF ATTEMPT TO ENTEH
INTO AN AGREEMENT WITH OTHER REGISTRANTS
FOR DEVELOPMENT OF DATA
am duly authorized to-represent the following firmly who are subject to the require-
lentJ of a Notice under FiFRA Section 3{e«2)(B) contained in a Guidanca Document
5 submit data concerning the active ingredient:
GUIDANCE DOCUMENT DATE
ACTIVE INGREDIENT
NAME OF FIRM
EPA COMPANY NUMBER
is firm or group of firms is referred to below as "my firm".)
firm is willing to develop and submit the data as required by that Notice, if necessary. However, my firm would prefer to enter
no an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following required
ems or data:
My firm has offered in writing to enter into such an agreement. Cooies of the offers are attached. That offer was irrevocable and included an offer to be
ound by an arOitration decision under FIFRA Section 3(c)(2)(B)(lii) if final agreement on all terms could not be reached otherwise. This offer was made
o the following firm(s) on tne following date(s):
NAME OF FIRM
DATE OF OFFER
yvever, none of those firm(s) accepted mv offer.
firm requests that EPA not suspend the registration(s) of jny firm's product(s), if any of the firms named in paragraph (3) above
lave agreed to submit the data listed in paragraph (2) above in accordance with the Notice. I understand EPA will promptly inform
Tie whether my firm must submit data to avoid suspension of its registration(s) under FIFRA Section 3(c)(2)(8). (This statement
Joes not apply to applicants for new products.) I give £?A permission to disclose this statement upon request.
'ED HAMS
SIGNATURE
OATE
8S80-6 110-82)
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213
PRODUCT. SPECIFIC DATA REPORT
EPA Reg. No.
Date
Guidance Document for
Registration
Guideline No.
§158.120
PRODUCT
CHEMISTRY
61-1
61-2
61-3
52-L..
&£.—£
• ' ' *• ' -, •;
62-5
Name of Test
Identity of
ingredients
Statement of
ccmcosition
Discussion of
formation of
ingredients
Preliminary
analysis
Cemficacicn of.
limits
Analytical methods
for enforcement
limits
Test not
reguired
for my
product
listed
above
(check
below)
I am comply ing with
data requirements by
Citing MRID
Number or
EPA Accession
Number
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
63-11
63-12
Physical state
Odor
Melting point
Boiling point.
Density, bulk-
density, or
specific gravity
Solubility
Vacor oressure
Dissociation
constant
Octanol/water
partition
coefficient
cH
1
1
1
•
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214
Registration
Guideline No.
63-13
63-14
63-15
63-16
63-17
63-18
63-19
63-20
• 63-21
§158.135
TOXICOLOGY
Name of Test
•Stability
Oxidizing/ reducing
reaction
Flammability
Explod ability
Storage stability
Viscosity
Miscibility
Corrosion
characteristics
Dielectric break-
down voltage
81-1 Acute oral
• • '• . | toxicitv, rat
81-2
81-3
81-4
Acute dermal
taxi city, rabbit
Acute inhalation ,
toxicity, rat
Primary eye
Test not
required
for ray
product
listed
above
(check
below)
I am complying with
data requirements by
Citing MRID
Number or
EPA Accession
Number
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
51-::
81-6
Primary ^amaj.
irritation
Dermal sensitiza-
tion
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215
PORMULATOR'S EXEMPTION STATEMENT1
(40 CFR 152.35)
EPA File Symbol/Reg. No. Product Name
Applicant's Name and Address
As an authorized representative of the applicant for registration of the
product identified above, I hereby certify that:
(1) This product contains the active ingredient(s):
(2) Each active ingredient listed in paragraph (1) is present solely.
as the result of the incorporation into the product (during formulation or
packaging) of another orcduct which contains that active ingredient, which
is registered'Under-FIFRA sec. 3, and which is purchased by us from another
orod'ucer.
(3) • Indicate by circling (A) or (B) below which paragraph applies:
(A) An accurate Confidential Statement of Formula (EPA Form 8570-4) for
- ihe above identified crccuct is attached to this statement. That formula
cuatanen- .ncicac3S, ~y zcrmar.y -.ame, reqiarraticn numcer 3nd crcducr
name, the source of trie active ingredient(s) listed in paragraph (1).
CR .
(B) The Confidential Statement of Formula dated on file with
the EPA is complete, current and accurate and contains the information
required on the current CSF Form No. 8570-4. The registered source(s)
of the active ingredient(s) listed in paragraph (1) is/are listed below:
Active ingredient Source; Product name and Reg. No.
Signature
Date Title
EPA Form fApril 1985)
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