EPA Report
                                         April, 1979
UPTAKE OF KEPONE FROM SUSPENDED SEDIMENTS BY
     OYSTERS AND OTHER BIVALVE MOLLUSCS
                     by
 Dexter S. Haven and Reinaldo Morales-Alamo
    Virginia Institute of Marine Science
      Gloucester Point, Virginia 23062
           Grant Number R804993010
               Project Officer
               Tudor T. Davies
Gulf Breeze Environmental Research Laboratory
         Gulf Breeze, Florida 32561
Gulf Breeze Environmental Research Laboratory
     Office of Research and Development
    U.S. Environmental Protection Agency
         Gulf Breeze, Florida 32561

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                                 DISCLAIMER

     This report has been reviewed by the Gulf Breeze Environmental Research
Laboratory, U.S. Environmental Protection Agency, and approved for
publication.  Approval does not sig-nify that the contents necessarily reflect
the views and policies of the U.S. Environmental Protection Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation  for use.

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                              ACKNOWLEDGEMENTS




     The contributions to this work by Dr. Michael E. Bender, Head of the



VIMS Division of Environmental Science and Engineering and Dr. Robert J.


                                                 ~9^
lluggett, Head of the VIMS Department of Ecology -*«o Pollution and Project



Manager for this research are gratefully acknowledged.  Appreciation is also



expressed to Harold D. Slone and his assistants for sample analysis, to



Gloria B. Rowe  for her assistance in transcription of this manuscript and to



Kay B. Stubblefield and her staff at the VIMS Art Departnent for preparation



of the figures.  Final copy of this report was prepared by the VIMS Report



Center.

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                                  SECTION 1
                                INTRODUCTION
     This report presents results of experiments on uptake of Kepone by


bivalve molluscs conducted between October 1977 and February 1979 by the


Virginia Institute of Marine Science under-a contract with the Environmental


Protection Agency  (Grant Identification Number:  R804993010).  An earlier


report submitted to  the EPA contained the results of similar experiments


conducted during the period between October 1976 and October 1977 (Haven and


Morales-Alamo,  1977).



     Between  October 1977 and February 1979 twelve laboratory experiments


were conducted  with  the American oyster Crassostrea virginica in trays


receiving suspended  sediments contaminated with Kepone.  The contaminated


sediments were  collected from the James River in the vicinity of Hopewell.

~Two
To  similar experiments were conducted with the Asiatic clam Corbicula


manilensis and  one with the coot clam Mulinia lateralis.  Data on


concentrations  of  Kepone in oyster biodeposits were collected from  five


experiments using  contaminated  sediments in suspension.  In nine of the


experiments with oysters and in the one with M. lateralis, samples  of  the


contaminated  animals were placed in uncontaminated river water for  periods  of


time ranging  between one and three weeks to study depuration.



     In addition to  the laboratory studies, two series of experiments  were


conducted on  piers at  Skiffes Creek (Fort Eustis Port) and Deep  Creek


(Menchville Marina)  in which water from the creeks was pumped over  trays

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  X
:upneatz
holding individuals of the wedge clam Rangia cujineata and oysters,




respectively.







     Another group of experiments was conducted at three stations in the




James River (Wreck Shoal, Point of Shoals and Deep Water Shoal) in which




oysters were held in wire trays on the river bottom.  Sediment-collecting




containers were also positioried7"on the bottom, adjacent to these trays.







     Many details on materials, methods and procedures were described in the




EPA Progress report for  the period October 1976 - October 1977Q (Haven and




Morales-Alamo, 1977).  Consequently, they have been omitted from this report

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                                  SECTION 2
                            MATERIALS AND METHODS
Uptake Studies Using Sediment Suspensions in the Laboratory







     The experimental procedures and data analysis in these experiments are




given by Haven and Morales-Alamo (1977).  Contaminated sediments came from




the vicinity of Hopewell, at Jordan Point and Bailey Creek, in the James




River.







     The apparatus used  in laboratory studies in which sediment suspensions




contaminated with Kepone flowed over animals in plastic trays was described




earlier (Haven and Morales-Alamo, 1977) and is illustrated again in Figure 1




of the present report.  A minor change made in the apparatus consisted of




replacement of the rectangular mixing chamber with a circular one.  Water




flowed directly into the circular chamber and out into the experimental trays




through a standpipe with a 1.2 cm diameter opening.







Studies of Accumlation of Kepone in Oyster Biodeposits







     Five studies were conducted in which biodeposits produced by oysters




receiving contaminated sediments in suspension were collected and analyzed




for Kepone contents.  The oysters were held in the large, compartmentalized,




trays.  Biodeposits and  sediments settling out by gravity were collected

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                                                                                     rET£
                                                                                      n

                                                                                   "
daily in separate containers.  The aggregates accumulated in the containers


at the end of each contamination period were analyzed for Kepone.  Each day,


after biodeposits and sediments had been collected, every compartment was


cleaned of any remaining material.



     In two experiments conducted between November 1978 and January 1979.no


data were collected for gravity-settling sediments.  In the first case, the


experiment was conducted as  a part of another study and the sediments


settling out by gravity were not collected.  In the other experiment the


concentration of sediments in suspension was so low that volume of sediments


settling out were not measurable.



Uptake Studies Using Water Pumped From Two Contaminated Creeks



     Field uptake studies were conducted on piers at tributary creeks of the


James River:  Skiffes Creek  and Deep Creek, located on the north shore of the


river, 46 and 30 km from the mouth, respectively (Figure 2).  The apparatus


used at both stations was the same (Figure 3).



     A galvanized steel pipe (A) buried in the bottom and fastened to the


pier structure held in place a small submersible pump (B) about 20-30 cm from


the bottom.  Water depth at  the Ft. Eustis pier (Skiffes Creek) was about


3.7 m.  At the Menchville Marina dock (Deep Creek) it was about 1.5 m.  Water


was pumped continuously into a 38-1 rectangular plastic aquarium (C) from


which it overflowed continuously back into the creek.  Water was pumped


intermittently out of the aquarium by a submersible pump (D) into a 49-1


plastic storage carboy (E).  Water collected in the carboy was used for


determination of Kepone in the suspended particulate matter.  Pump D was

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                                   3
connected to an interval timer (F) that regulated pumping at intervals that




fluctuated randomly between two and eight seconds out of every hour.







     Water was siphoned out of aquarium C through small-bore tubing (G) into




one or two plastic trays (H) holding the experimental animals and into a




similar control tray without animals.  These trays were identical to those




used to contaminate oysters and darns with sediment suspensions in the




laboratory as described in Haven and Morales-Alamo (1977).  Water overflowed




out of the trays into a collector trough (I) that emptied into the creek




through a piece of plastic tubing (J).  The whole system was enclosed in a




locked^large plywood box that protected it from weather and people.







     The experimental site was visited daily.  Hydrographic measurements as




well as measurements of the water flow into the experimental trays were made




at that time.  The carboy with water accumulated since the previous day was




replaced with an empty one and taken back to the laboratory for extraction of




the particulate matter by centrifugation.







     After determination of the total volume contained in the carboy, the




water was centrifuged the same day using a high-speed centrifuge with a




continuous-flow attachment and operated at 14,000 RPM with water flowing at a




rate of 1 1/m.  The sediments collected each day were combined for the period




of time that the experimental animals were exposed to contamination, which




was usually- seven days, but at times was shorter or longer.  After removing




salts by rinsing in de-ionized water, the sediments were dried, weighed and




analyzed for Kepone.







     At the end of an exposure period, samples of the molluscs were taken

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from the trays and deposits (sediments and biodeposits) that had accumulated




in each tray were collected.  The trays were  rinsed with creek water before




animals were put back.  Height (distance between  umbo  and valve margin) of




molluscs in the sample y&re measured and their  meats analyzed for Kepone.




The deposits collected were washed free of salt,  dried and also analyzed for




Kepone content.







     At the end of each week, new uncontaminated  animals were placed in one




of the trays from which all previous occupants  had been removed.  Thus, that




tray never held animals longer than one week.   The data on these animals were




used for comparison with the data obtained by holding  other animals for




longer periods of time in similar trays.







Studies in Which Oysters were held in Trays on  the James River Bottom







     A series of field studies was conducted  in which  uncontaminated oysters




and/or Rangia clams were exposed to contamination in trays on the river




bottom at three stations in the James River (Wreck Shoal, Point of Shoals and




Deep Water Shoal; Figure 3).  At the same time  suspended sediments settling




out in the vicinity of the tray were collected  in a sediment trap placed on




the bottom adjacent to the tray.







     Oysters were lowered to the river bottom at  each  of the three stations




in a tray made of wire.  A 2.5 cm mesh wire cover was  fastened to the  tray




top.  The tray was 103 cm long, 48 cm wide and  10 cm deep and had a 2.5 cm




mesh size.  A rope from the tray to the water  surface  was tied to a stake and




was used to lifj? the tray out of the water for  sampling.







     Rangia clams were lowered to the bottom at Deep Water Shoal (Figure 2)
                                                                             AFT

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                                                                        "—' m ft.

in a galvanized-wire bag with a 2.5 cm mesh.  The bag was 61 era long, 30.5 cm


wide and 10 cm deep.  A rope from the bag was tied to a stake at the water


surface.



     The sediment trap consisted of two plastic bottles held in a truncate


pyramid made of concrete (Figure 4).  The base of the pyramid was 44.5 cm on


two sides and 43 cm on the other" and' its height was 16.5 cm.  The top was 15


x 15 cm.  Two holes side by side on the top of the trap measured 7.3 cm in


diameter and 13.5 cm in depth.  Two 500-ml plastic bottles, 16 cm high and


7.3 cm  in diameter with a mouth 4.3 cm in diameter were inserted in the holes


to serve as sediment collectors.  Tape wrapped around the bottle served to


hold it in the hole by friction.  The top edge of the bottle protruded


2.5 cm  out of the hole.  A rope from the trap bridle was tied to the same


stake that the oyster tray or Rangia bag was tied to.



     These stations were visited weekly except when weather or other


unfavorable circumstances interfered and samples of animals were collected


for Kepone analysis.  A new group of animals was placed in the tray or wire


bag when the last ones of a group were removed.



     At each sampling time the bottles in the sediment trap were removed and


replaced with empty ones.  In the laboratory, the sediments collected in one


of the  two bottles were washed free of salts, dried and subsequently analyzed

                                                       (/V-tL^y
for Kepone..  Sediment in several of the other bottles v&&e stored in a
refrigerator and subsequently selected ones were analyzed for particle size.



     Samples for size analysis were washed free of salt and shaken  for 24


hours in a wrist-action shaker after addition of sodium hexametaphosphate  as

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                                                                                   • 1

                                                                                   r
a dispersant.  Sediments were then wet-sieved through a 63^< screen to

separate sands from silt and clays.  Sands were oven-dried at 87°C and

weighed without further screening.  The silt-clay fraction was transferred to

a 1000 ml cylinder and analyzed by the pipette method (Krumbein and

Pettijohn, 1938).


     Additionally, samples of oy'steVs from natural beds and bottom sediments

were collected and analyzed for Kepone.  Oysters were dredged up and a sample

of the sediments brought up in the dredge was collected by scooping up a

portion of the surface layer identifiable by its brownish coloration.


Source of Experimental Animals


     All oysters used  in these experiments were collected from the Piankatank

River  (Figure 5) and were  found to be free of Kepone at the start of all

experiments.  Rangia clams were collected from the fresh water reaches of the

Rappahannock River about 68 km upriver (Figure 5), and were also free of

Kepone.


     Corbicula clams were  collected from the James River about four km above

Hopewell.  Corbicula could not be  found further upriver between that point

and Richmond.  As expected, the Corbicula collected had Kepone in their

meats.  They were held for three weeks in running freshwater in the

laboratory receiving supplementary starch suspensions as food prior to use in

the experiment.  However^  they still had Kepone after that period of time.


     The Mulinia clams were hatched and reared at the Virginia Institute of

Marine Science laboratories in Wachapreague, Virginia and came from water

with a salinity of 30 °/oo.  They were held in standing water in a

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refrigerator (10°C) at Gloucester Point while the water salinity was lowere



by replacement with York River water.  Every 24 hours the water was changed



and an increasing proportion of York River water was added to the container



until the salinity was lowered to that of the York River which was 20 °/oo at



the time.  That was accomplished in  four days.  At the end of that period



they were taken out of the refrigerator and allowed to reach room
                                • ~ ;•>


temperature.  Then they were placed  under running York River water at ambient



temperature, which at the time was 28°C.




Preparation of Laboratory Sediment Suspensions




     Sediment suspensions used in laboratory experiments were prepared



following in the manner described in Haven and Morales-Alamo (1977).  To



improve homogeneity of dosage through the duration of an experiment, slight



modifications were made in the procedure described there.  The sediments from



all bags brought in from the James River were mixed together in a large tub.



Small plastic bags were filled to a  volume of approximately 500 ml and



numbered in the order they were filled.




     Only sediments collected on the same data were used in any one



experiment.  Sediment suspensions for the studies were prepared at the same



time from two bags by pairing bags from opposite ends of the numerical



progression created when the bags were filled; for example, the first bag



filled was paired with the last one  filled.  Thus, successive pairs of bags



showed a simultaneous progression from the lowest number up and the highest



number down.




     The resulting paired stock suspensions in 6000 ml flasks were combined

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by siphoning their contents simultaneously into a series of five flasks in



equal volumes (2000 ml) and into two extra containers in volumes



approximately 400 and 200 ml, respectively.  Samples in the two extra



containers were used for Kepone and sediment concentration analyses.





     The stock suspension in the 2000 ml flasks was the material introduced



into the experimental trays by means' of a peristaltic pump.  It was usually


                                                  oi                  .     ~) u^ *
diluted with tap water by factors ranging between iwc and 12 before being  C    t~-H*/fl



pumped into the experimental trays.  The dilution factor used depended on the



concentration of Kepone in the stock solution and the final concentration



desired.  The flow of York River water used was kept constant and control of



the  final suspension was, therefore, determined by the concentration of the



stock suspension being pumped into the trays and the rate at which it was



pumped .





     The ratio of particulate material in the stock suspensions prior to



entering the mixing chamber to particulate material in the York River water



at the same point was very large.  The concentration of particulate matter in



the  stock suspensions usually ranged between 15,000 to 40,000 mg/1 with an



average between 25,000 and 30,000 mg/1 while that in the York River water



usually ranged between 5 and 15 mg/1, with an average of 7 to 10 mg/1.



Therefore, sediment particles in the York River water constituted an



insignificant factor (usually less than 10%) in the final composition of the



particulate matter flowing over the oysters in the experimental trays.



Consequently, the composition of the material found in the oysters' gut at



any  time would be, for all practical purposes, that of the original sediments



used to prepare the stock suspensions.

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Determination of Kepone Concentration in Sediment Suspension







     The concentration of Kepone in the diluted sediment suspension flowing




over the experimental animals was determined by computation of the product of




four factors:
                        Kc =   (s-c}:, .(kc)   (dx)  (d2)
where
     KC = computed Kepone  concentration  in diluted suspension, in ppb ( g/1)







     sc = sediment dry weight per unit volume in stock suspension, in Kg/1







     kc = Kepone concentration determined analytically for dry sediments in




          stock suspension, ppm  (f!g/g).







     d^ = factor by which  stock  suspension was diluted prior  to being pumped




          into mixing chambers.







     d2 = factor by which  the suspension being pumped into mixing chambers




          was diluted; determined by  the flow rate at which it was being




          pumped and the  flow rate  of York River water flowing simultaneously




          into the mixing  chamber.







     The factor d2 was controlled in  each experiment by selection of




peristaltic pump settings  that would  deliver a desired flow rate of the




sediment suspension into  the mixing chamber.  Flow of river water was




maintained relatively constant while  the flow rate of contaminated sediments




was adjusted so that trays would receive sediment suspensions at different




rates.

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                                                                                    T
Determination of Kepone Concentration in Suspended Sediments







     The computations used for determining the concentration of Kepone in the




diluted sediment suspensions flowing over the experimental animals in




laboratory trays are described in Haven and Morales-Alamo (1977).  The




following clarification is necessary.  The value obtained for concentration




of Kepone in the sediment suspension is given as parts-per-billion.   It




should be understood that this represents mass of Kepone per unit volume of




water (J4g/l~).  The assumption has been made that the Kepone present  is




associated only with the particulate matter.  The section entitled




Preparation of Data for Analysis in Haven and Morales-Alamo (1977) is




pertinent to this subject and should be consulted as needed.
   A 24*e""field  studies  in which creek water was pumped into trays with




animals at Skiffes Creek and Deep Creek, the concentration of Kepone in the




sediment suspension  flowing into the trays was established as follows:  The




concentration of  sediments in  the water was determined by dividing the weight




of the dried sediments  collected by centrifugation by the volume of water




centrifuged.  This value was then multiplied by the concentration of Kepone




in the dried sediments  to obtain the concentration of Kepone in terms of mass




per unit volume of water.  As  was the case in  laboratory studies, all the




Kepone in the sediment  suspension flowing over the animals was assumed to be




associated with the  particulate fraction of the suspension.







Determination of  Concentration Factors







     Two types  of concentration factors were computed to compare the  •




concentration of  Kepone in the meats of the bivalves and in their biodeposits

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with the concentration in the contaminated sediments and the suspensions


derived from them.  One was based on the concentration of Kepone per unit


volume of suspension  flowing into the experimental trays after the
contaminated sediments were diluted with seawater.  The other one was based
                                            A

on the concentration of Kepone actually associated with the sediment


particles  (also termed "dry sediments" in our tables and figures) used to


prepare the suspensions.




     These two concentration  factors represent analogies of the


bioconcentration  and bioaccumulation factors in wide use in the literature on


uptake of  chemical  compounds  by  aquatic organisms (see, for example, Bahner,


JLL J*L' > 1977).  The bioconcentration factor  is defined by Hamelink  (1977) as


the concentration of a compound  in  the organism at the steady state divided


by the concentration of the compound in the  water (generally understood to


mean in solution  in the water).   In this case, the compound is being taken


directly from the water by the organism.  The bioaccumulation factor is


defined by Bahner-  et al. (1977)  as the concentration of the compound in a


predator divided  by the concentration of Kepone in that predator's  prey.  In


this case, the compound is taken  by an animal through ingestion of  another


animal containing that compound.




     The processes by which bivalves would take up Kepone from solution in


water and  from the  fraction adsorbed on the  surface of sediment particles are


different  from each other.  Nevertheless, the technique for computation of

                                                  ,   .                    ~>  .
the corresponding concentration  factors is similar,  .therefore, the        I  y


concentration factors may be  considered analogous.  In both instances the


mass of Kepone in an organism is  compared to (and divided by) a known mass of

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"RAi
                                                                                •a
                                                                         fj
Kepone contained in a unit  volume of water.  This analogy justifies  our  use
of a concentration factor based  on  the concentration of Kepone  in  sediment
suspensions diluted to a variety of levels.

     Contamination of bivalves  by ingestion of sediment particles  with Kepone
adsorbed to their surfaces  is also  akin  to the process of bioaccumulation.
Therefore, a concentration  factor Based  on the Kepone associated with  the
sediment particles in suspension (ignoring their concentration  per unit
volume of water) can be considered  analogues to the bioaccumulation  factor as
defined above.

     The concentration factor that  takes into account the dilution of  the
sediment suspensions is emphasized  throughout this report.  The concentration
factor based exclusively on the Kepone associated with sediment particles  is
used to a lesser extent when required to explain certain specific  points.
Emphasis on the former was  required because the concentration of Kepone  per
unit volume of suspension had a direct bearing on the quantity  of  Kepone
taken up by the bivalves while the  concentration in the sediments  did  not, by
itself, determine the quantity found in  bivalves.

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                                                                L4:;
                                                                VJ-.F ti ^- "
                                    REFERENCES


Bahner, L. H., A. J. Wilson, Jr., J. M. Sheppard, J. >'. Patrick, Jr., L. R.
     Goodman  and C. F. Ualsh.   1977.  Kepone^ bioconcentration, accumulation,
     loss, and transfer  through estuarine food chains.  Ches. Sci.
     18:299-308.

Bender, M. E., R. J. Iluggett and W. J. Mar?is, Jr.  1977.  KenoneR residues
     in Chesapeake Bay biota.   In:  Proc. 10th National Shellfish Sanitation
     Workshop  [D. S. Wilt, Ed.], Hunt Valley, Md . , U.S. Food and Dru.e
     Administration, pp. 66-71.

Hamelink, J.  L.  1^77.   Current bioconcentration  test methods and theory.
     In:  Aquatic Toxicology and Hazard Evaluation, ASTM STP 634 (F. L. Mayer
     and J. L. Hamelink, Eds.).

Hamelink, J.  L., R. C. Waybrant and R. C. Rail.   1971.  A proposal:   Kxchanpe
     equilibria control  the decree chlorinated hydrocarbons are biologically
     magnified in lentic environments.  Trans. A^er. Fish. Soc. 100:207-214.

Haven, D. S.  and R. Morales-Alamo.  1966a.  Aspects of biodeposition bv
     oysters  and other invertebrate filter feeders.  Lirnnol. Oceanogr.
     ll:4S7-498.

	 and 	.  1966b.   Use of  fluorescent particles to trace oyster
     biodeposits in marine sediments.  J. Cons.  Intl. Explor Mer 30:267-269.

     and 	.  1972.  Biodeposition as a factor  in sedimentation of fine
     suspended solids in estuaries.  In:  Environmental Framework of Coastal
     Plain Estuaries (B. W. Nelson, Ed.), deol.  Soc. America Memoir 133, pp.
     121-130.

     and      .  1977.  Uptake of Kepone from suspended sediments by oysters,
     Rangia and Macoma.  In:  The Role Uptake of  Kepone in Estuarine
     Environments (R. J. Hugpe'tl'V Project Manager), Proceedings of the Kepone
     Seminar  II, September 1977,/U.S. Environmental Protection Apency, Region
     III, pp. 394-447.	.
Haven, D. S., F. 0. Perkins, R. Morales-Alamo and >'. V.'. Rhodes.  1977.
     Coliform depuration of Chespapeake Bay oysters.  In:  Proc. 10th
     National Shellfish Sanitation Workshop,  [D. S. Wilt, Ed.], Hunt Vallev,
     Md., U.S. Food and Drue Administration, pp. 49-59.

                                                                 yyv^rvXA^jL^JC

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Xracniter, J. N., D. s. Haven and R. Morales-Alamo.  O-'P in preparation).
     Sediment mixing, by estuarine invertebrate species and communities.

Krumbein, V. C. and F. J. Pettiiohn.  1938.  Manual of Sedimentary
     Petrography.  Appleton-Centnry-Crofts , New York, 5^9 pp.

Mayer, F. L.  1976.  Residue dynamics of di-2-ethyIhexyl phthalate in fathead
     minnows (Pimephales promelas).  J. Fish Res. Bd. Canada 33:2610-2613.

Nichols, M. M.  1972.  Sediments of the James River estuary, Virginia.  In:
     Environmental Framework of Coastal Plain Estuaries (B. W. Nelson, EC'.),
     Geol.  Soc. America Memoir  133, Dp. 16°-212.

Nichols, M. M.  and R. C. Trotman.   1977.  Kepone  in James River Sediments.
     An annual  progress report  to EPA.  In:  The  Role of Sediments in the
     Storage, Movement and Biological Uptake of Kepone in Estuarine
     Environments  (R. J. tlugRett, Project Manager), Proceedings of ''eoone
     Seminar II, September 1977, U.S. Environmental Protection Agency, Region
     III, pp. 365-382.

Onishi, Y.  and  R. N. Ecker.  1978.  The movement  of Kepone in the James
     River.  In:  The Feasibility of Mitigating Kepone Contamination in the
     James  River Basin (G. W. Dawson, Project Director).  Appendix A, p.
     VTI-1  to VII-85.  Report by Pacific Northwest Laboratory (Batelle
     Memorial Institute, Richland, Washington, to the U.S. Environmental
     Protection Agency.

  Schneider, M. J. and G. W. Dawson.  1978.  Ecological effects of Kepone.
       In:  The Feasibility of  Mitigating Kepone  Contamination in the James
       River Basin (G. W. Dawson, Project Director).  Appendix A, p. VIII-1
       to VIII-27 .  Renort by Pacific Northwest Laboratory (Batelle Memorial
       Institute), Richland, Washington, to  the U.S. Environmental Protection
       Agency.

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                                                                        -LJ
                                  SECTION 3







                                   RESULTS












Laboratory Experiments with Sediments in Suspension







     Results  from  laboratory experiments in which oysters, Corbicula




manilensis and Mulinia lateralis were exposed to suspensions of sediments





contaminated  with  Kepone are given separately below for each species.







     No laboratory experiments with Rangia cuneata were conducted in 1978-79




However, the  data  collected in 1976-77 are re-introduced  in this section to




present some  aspects not covered in our previous report.







     Unless specified otherwise, the concentration factor used throughout




this section  is based on the concentration of Kepone per  liter of sediment




suspension.   The data are separated into series as a convenient way to




distinguish between experiments conducted at different times.







Crassostrea virginica—







     Fourth series—This series of experiments was conducted between 6




October and 4 November 1977 at ambient York River water temperatures.  Mean





weekly water  temperatures ranged between 15.7 and 19.9°C  (Table 1).  Mean




weekly salinity ranged between 22.9 and 24.0 °/oo.

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       Oysters, ranging  in height  between  6  and 9 cm, were  subjected  to  two




  different concentrations of Kepone  in  sediment suspensions.  The mean  hourly




  concentration for  the  different  weekly periods ranged between 0.05  and 0.08




//g/1 in one tray and between 0.19  and 0.25,«g/l in  the other.  Oysters  in a




  third tray receiving uncontaminated York River water were maintained as a




  control.







       At  the  lower  mean concentrations  (0.05-0 .OS^g/l) oysters concentrated




  Kepone by factors  ranging  between 1372 and  1805 (Table 2).  Concentration in




  the animal tissues leveled off  after the second week of exposure (Figure 6) .




  This curve is similar  to those  obtained  in" earlier experiments where a




  leveling off after the first  or  second week was usually suggested.  The




  highest  mean concentration in oysters  in any weekly period  was 0.13/xg/l (wet




  weight).







       At  the  higher mean concentrations (0 .19-0.25/ig/]joysters concentrated  T




  Kepone by factors  ranging  between 914  and  1581 (Table 2).   Concentration in




  the animal tissues increased  with the  time  of exposure through the  four weeks




  duration of  the experiment, up  to a level  of 0.40/<.g/g (Figure 7).  This




  increase is  associated with the  increase in mean hourly concentration  of




  Kepone in the sediment from one  week to  another.







       Uncontaminated oysters were  introduced at the start  of the  third  and




  fourth weeks into  the  tray receiving the higher of the two  concentrations of




  Kepone and also at the start  of  the fourth  week into the  tray receiving the




  lower concentrations of Kepone.   This  was  done to  compare accumulation of




  Kepone between newly-exposed  oysters and oysters that had been already




  exposed  to contaminated sediments for  the  preceding two and three weeks.

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     In all three instances, the newly-introduced oysters showed Kepone




levels only slightly lower than those found in the oysters that had been




exposed to contamination for the preceding two or three weeks (Table 3,




Figure 7).








     As part of the fourth series of experiments, oysters were taken out of




the trays in which they were-being exposed to contaminated sediment




suspensions and transferred for depuration to trays receiving uncontarninated




York River water.  This was done at the end of the second and third weeks of




exposure to contamination.  The three groups of oysters thus subjected to




depuration for one week showed reductions in the level of contamination




between 76 and 80 percent (Table 4, Figure 8).  Not much difference was




evident between oysters that had been receiving the higher concentrations of




Kepone and those that received the lower concentrations in terms of percent




reduction.  The level attained after depuration by those that received the




lower concentration was only slightly lower than in those that received the




higher concentrations.







     Fifth series—The purpose of this  series of experiments was to study the




rate at which oysters contaminated with Kepone in the laboratory depurated




when held in flowing, Kepone-free water, also in the  laboratory.   For  that




reason, the concentration of Kepone in  the sediment suspensions flowing over




the oysters during contamination was not measured.







     The experiments were conducted between December  8, 1977 and January 13,




1978.  York River water temperature was raised with heat exchangers to a




range in weekly means between 17.2 and  19.5°C (Table  5).  Mean weekly





salinity ranged between 16.3 and 18.4 °/oo.

-------
     Fifty-four oysters were placed in a  large tray (81 cm long, 55 cm wide


and 9 cm deep) receiving suspensions of sediment contaminated with Kepone.


At the end of one week (December 15), samples of the oysters were taken out


from Kepone analysis.  Eighteen of the oysters were transferred to another


tray receiving Kepone-free oysters from the York River.  Another group of 18


Kepone-free oysters from the original stock collected from the Piankatank


River was introduced  into the contamination tray at the same time.  These


newly-introduced oysters were properly identified to separate them from those


which had already been in the tray for one week.



     At the end of  the second week (on December 23), samples of oysters from


each of the two groups in the contamination tray were taken out for analysis.


Samples of depurating oysters were also taken out for analysis.  The oysters


remaining in  the contamination  tray were  transferred to trays receiving clean


York River water.



     Figures  9 and  10 and Table 6 sunmarize the data on uptake and depuration


of Kepone by  oysters  in the  fifth series  of experiments.  After the first


week of exposure to contamination, three  samples of oysters showed an average


concentration of Kepone of 0.42 ppm (Figure 10).  Following one week of


depuration, the level of Kepone in samples of this group of oysters decreased
                            s      •—••w
by 65% to 0.14 ppm.  In  thef followingN two/ weekly  period of depuration, the


concentration decreased  at  a  slower  rate  of  0.07  in  the second week  and  to


0.03 in the third week.



     Samples of oysters  that  remained  in  the contamination tray  for  two  weeks


showed a mean concentration of  0.68  ppm  (Figure 10,  solid circles).


Following one week of  depuration  the average concentration of Kepone in

-------
samples of these oysters decreased by 56% to 0.30 ppm.  After the second week

of depuration, concentration had decreased by 85% to 0.10 ppm.  During the

third week of depuration there was a slight aberrant increase in

concentration from 0.10 ppm to 0.19 ppm, which probably represents chance in

sampling.


     Oysters  introduced into'CKe-contamination tray at the end of the first

week an'd sampled one week  later had a mean concentration of Kepone of 0.58

ppm  (Figure 10).  This value was significantly higher than that for oysters

analyzed after exposure during the first week of the experiments, but similar

to that for those exposed  for two weeks.  We do not have any data for the
                                                                          -)
concentration of Kepone in the sediment suspensions, but we do|(now that the >

two  groups of oysters sampled at the end of the second week were receiving

the  same concentration in  suspension.  The concentration in suspension during

the  first week was probably lower than that for the second week.


     After one week of depuration, the mean Kepone concentration in samples

of oysters from this group decreased by 75% to 0.14 ppm (Table 6).  The rate

of decrease was much lower during the following two weeks.  After two weeks

of depuration the mean concentration of Kepone was 0.095 (a total reduction

of 83%) and after three weeks it was 0.09 (a total reduction of 84%).


     Sixth series—This series consisted of an experiment in which two groups

of oysters were exposed for one week to contamination with Kepone from

sediments in  suspension and subsequently depurated.  One group received York

River water at ambient temperature (which at the beginning of the experiment

was  9.0°C) and the other received York River water which had been heated up

to 20-21°C.  The total depuration period was 15.6 days.  Oysters were sampled

-------
six days after initiation  of  depuration and again after another 9.6 days.


     At the end of  the  one-week contamination period there was very little

difference in the Kepone concentration between the two groups of oysters,

0.34 vs. 0.36^<_g/g  (Figure 11"").   The mean temperature for that week in the

ambient-temperature tray was  11.0°C with a range of 9.0-13.8°C (Table 7).  In

the tray receiving  warm water "the mean was 21.1°C with a range of

10.8-23.5°C.  The  lower temperature in this range represents a temporary

malfunction of  the  heat exchanger system.
*  Figure  11  also includes contamination and depuration data  for experiments

   conducted  between 12 January and 5 February 1979.
                                                             <•- -  ^- —
                                                 ^_^.-\'"^     ~_  -r -c:
                                                     , ^^~   "  "=~"   -.'-
                                                 -^-" "^ _ ^.v-,-.-'—'?
                                                                              -i<
                              } •:„
                            \*c*\d^

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     There was marked difference between  the  two  groups  of  oysters during  the


first week of depuration  (Figure 11, Table  8).  Oysters  depurating in 23°C


water showed a 69% reduction  in their  concentration of Kepone.  Those


depurating in 13°C showed only a 9% reduction in  Kepone  concentration.



     During the second week of depuration,  however, the  reduction rate of

Kepone was greater in the oysters held  in 15°C water than in those held in

24°C Vater (90% vs. 73%), so  that at the  end  of the two-week depuration


period, the Kepone concentration was the  same in  the two groups of oysters.



     Seventh series--An additional  series of  experiments was conducted

between 12 January and 15 February  1979 as  part of a separate study.  The

data are  included here because they are pertinent to the subjects covered in


this report.  They are summarized in Table  9  and  Figure  11.



     Oysters received a very  dilute suspension of sediments contaminated with

Kepone (mean hourly concentration = 0.12^/:g/l) for 10 days  and were

subsequently allowed to depurate at two different temperatures (mean, 10°C


and 16°C).  At the end of the contamination period the concentration of

Kepone in the oysters was 0.05//vg/g.   Considering the fairly low  level of

Kepone in the oysters at  the  start  of  depuration, the rate  of depuration was


slow at both temperatures.  It was  significantly  slower  than what was


observed  in the sixth series  when the  contamination level at start of


depuration was around 0.35/^g/g.


                                                                              [ Cnx-m.
     Following the first  week of depuration.oysters held in 16°C  water showed > )


a residual concentration  of Kepone  lower  than that in oysters depurated in

10°C water.  After two weeks  of depuration  the relationship between  the

-------
Kepone residue in the two groups was similar to that observed after the first




week.  Oysters in the warmer (16°C) water had half as much Kepone as those in




the colder (10°C) water.







     Kepone in oyster meat vs. Kepone in sediment suspensions—Figure 9 of




the annual report for 1976-77 (Haven and Morales-Alamo, 1977) showed the




regression of Kepone concentration in oyster meats on the Kepone




concentration in the sediment suspensions flowing over the oysters in




laboratory trays.  That regression analysis has been updated in the present




report by inclusion of additional data from experiments conducted after




September 1977.  Many of the new data correspond to concentrations of Kepone




higher than 0.15//g/l (ppb) in the sediment suspensions.  The correlation




coefficient did not change much (0.810 vs. 0.781) with inclusion of the




additional data (Figure 12).







     The regression line shows a positive correlation between the




concentration of Kepone in oysters and that in the sediment suspensions.




However, the slope of the line indicates a sharp decrease in the ratio of




Kepone in oysters (in/<:g/g or ppm) to Kepone in the sediment suspension




(in/,'g/l or ppb) as the latter increases.  This relationship is better




illustrated in Figure 13 where data extracted from the regression line in




Figure 12 are plotted in terms of the concentration factor against Kepone  in




the sediment suspension.  There is a sharp drop in concentration factor




between concentrations of 0.001 and 0.05/ig/l in the  suspension.  The




decrease is much slower at concentrations higher than 0.1
     Kepone  in oyster meats vs.  Kepone  in  sediment  particles — Al 1




concentration factors presented  so  far  have  been based on  the concentration

-------
of Kepone in the suspensions of sediments  flowing over the experimental




animals.  The quantity of Kepone per unit  volume of suspension was determined




by the quantity of Kepone adsorbed to  sediment particles as well as by the




extent to which the sediments were diluted by the water flow volume used to




transport them over the animals.   It was,  therefore, considered advisable to




compare the Kepone in oysters with the Kepone in the sediment used to prepare




the suspensions after they were dried  (Table 10).







     We found no evidence of a correlation between the Kepone concentration




in oyster meats and the Kepone concentration on the sediment particles




(Figure 14).  Similarly, there was a lack  of correlation between the




concentration factor based on the  Kepone adsorbed on sediment particles and




the Kepone on the sediment particles (Figure 15).  Hence, our data fail to




relate the concentration of Kepone in  the  sediments with that in oyster




meats, even though those sediments are the source of all the Kepone in the




sediment suspension flowing over the oysters.







     However, our data show that the Kepone concentration in oyster meats was




correlated with that in the sediment suspension given as mass of Kepone per




volume of water (Figure 12).  Examination  of the data on Table 10 shows that




when the same or similar concentration of  Kepone in dry sediments is diluted




by different factors, resulting in different concentrations in suspension,




the Kepone in oysters is also correspondingly different.  For example, on




week 4 of the period 24 February-27 March  1977 the Kepone in dry sediments




was practically the same in the three  experiments conducted (1.03-1.05) but




they were diluted to three different levels.  The result was that oysters




receiving the more dilute suspension had  a lower concentration of Kepone  in

-------
their meats than those receiving  the  less dilute  suspensions.   Observations




made for all other weekly periods were similar  to  the above concentration in




the oysters varied in direct relation with  the  extent to which  the original




sediments were diluted and independently from the  concentration in the




original dry sediments.







     The concentration factor "biased on Kepone adsorbed on sediment particles




shows "that the Kepone taken up by oysters constitutes only a small fraction




of the Kepone associated with  the sediment  particles.  In most  instances,




Kepone in oysters was under 20% of that on  the  sediments and the maximum




accumulation in oysters was 27.5%.







     Kepone in oyster biodeposits—Biodeposits  collected from trays holding




oysters  that were receiving contaminated sediments  in suspension exhibited a




compartmentalization of Kepone relatively similar  to that reported in the




1976-1977 annual  report  (Haven and Morales-Alamo,  1977).  The concentration




of Kepone in feces was,  in most cases, between  one and nine times higher than




the concentration in pseudofeces  (Table 11).  In  one exceptional case the




proportion was 88 to 1.







     The data collected  in  1976-1977  showed that  the concentration in




pseudofeces and  in sediments  settling  out by gravity were similar.  In most




cases  it was higher  in the  sediments  than in the  pseudofeces but not by  a




great  margin.  The 1978-1979  data, however,  showed sediments with a




concentration between  two and  seven  times greater than  in the pseudofeces




(Table 11).

-------
                                                l\
     Regression analysis shotted  that  there was a high correlation between  the


concentration of Kepone in oyster  feces and gravity-settling sediments and


the concentration in the sediment  suspensions (expressed as the mean hourly


concentration for the weekly period  immediately preceding collection of the


oyster sample).  The correlation coeffic/Sints were 0.839 and 0.906, S C

pseudofeces and the concentration  in  the sediment suspensions was 0.685


(Figure 18).



     Range of the concentration  factors (based on Kepone mass per liter of


suspension) for feces was between  15,275 and 133,333 (Table 11).  In


pseudofeces it ranged between  1,260  and 39,167.  Concentration of Kepone in


gravity-settling sediments was between 7,897 and 8,828 times higher than that


in the sediment suspensions.



     Oyster meats were  analyzed  for  Kepone in only two of the five


experiments presented in Table  11.   In those experiments the concentration


factor in oysters were  813 and 4,167.  Mean temperature for each of the three


contamination periods were:  16-25 August, 29.2°C; 6-13 October, 20.7°C; and


13-20 October, 19.0'C.



     The combined data  on biodeposits for the years  1977 to 1979 are


presented here in relationship to  the concentration  of Kepone adsorbed on  the


sediments used to prepare the  suspensions flowing over oysters (Table 12).


The concentration factors (based on  the Kepone associated with sediment


particles) ranged from  0.757 to  2.236 in feces and from 0.032 to 0.563 in


pseudofeces.  The concentration  in gravity-settling  sediments was between

-------
0.217 and 0.903 times that in  the original  sediments used to prepare  the




suspensions.







     Translated into percentages, the  concentration factors show that the




Kepone in the feces was between 62 and  224  percent of that found in the





original sediments.  Likewise, Kepone  in  the  pseudofeces was between  3 and 56




percent that in the original - sediments* while  in the gravity-settling




sediments it was between  22  and 90 percent.







     Regression analysis  showed a positive  correlation between Kepone in




feces and that  in  the original dry sediment (r = 0.932).  The same was true




for pseudofeces (r = 0.709)  and gravity-settling sediments (r = 0.915).




These correlations are  similar to those found between feces, pseudofeces and




gravity-settling sediments and Kepone  in  the  sediment suspensions.







Rangia cuneata—







     Kepone  in  Rangia meats  vs. Kepone in sediment suspensions—No  laboratory




experiments  were conducted with Rangia cuneata between October 1977 and




January 1979.   The data collected in  the  laboratory between October 1976 and




October 1977 are used in  the present  report to examine certain relationships




not dealt with  in  the 1976-77  report.







     The relationship between  Kepone  in the meats of Rangia clams and Kepone




in the sediment suspension flowing over them  in laboratory trays is




illustrated  by  the data plotted in Figure 19.  The data  used appear in Tables




2 and 3 of our  previous report (Haven  and Morales-Alamo,  1977).  A moderate




positive correlation of 0.614  was found.   As  was  the case  for oysters, the




ratio of Kepone in the  animal  meats  to that in the sediment  suspension

-------
decreased sharply as the  latter  increased.


     This suggested that  the concentration factor of Kepone for Rangia was

also negatively correlated to  the Kepone  in  suspension.  Figure 20

illustrates the relationship between these two parameters.  The correlation

coefficient was negative  but low. and the  slope of the regression line was not
                                s
significantly different f ronr zero at P =  0 .05. although it was different from
                                             /    .x^ V V >^  x
Bfmrt V XOiO/alLli

lkfr
f G
                                             ui.i zero at P = 0.10.  Due to
these low correlation coefficients no inferences will he made from these

data.


     A plot of Kepone in Rangia against Kepone on the sediment particles

showed no correlation between the two (Figure 21; Table 13).  Neither was

there any evidence of a relationship between the concentration factor in

Rangia (based on the Kepone adsorbed on the sediment particles) and the

Kepone on the particles (Figure 22; Table 13).


     As was shown for oysters, the extent to which sediments containing a

specific concentration of Kepone are diluted in water will determine the

concentration of Kepone in Rangia clams receiving the sediment suspension.


Corbicula manilensis—


     One contamination experiment was completed in the  laboratory using the

Asiatic clam Corbicula manilensis between 6 October and 4 November 1977.  The

Corbicula clams were obtained about 6.5 km upriver from Jordan Point in the
                     Qs
James River and, consequently, were found to be contaminated with Kepone.  We

tried unsuccessfully to depurate them before start of the experiment.  They

were placed in running freshwater from a ground well  (Temp. =  17°C) with  a
                            A

-------
         supplementary supply of cornstarch and York River sediments in suspension.




         They  were active during the three weeks that they were held under depuration




         conditions and mortalities were less than 3%.  Although those conditions were




         considered satisfactory for depuration, no reduction in Kepone was observed.







              Therefore,  the experiment was started with animals which already had




         some  Kepone in their tissues - (-CK 12^g/g) .   The Corbicula in the control tray,




         receiving a cornstarch suspension in ground well water, did not appear to




fj t&S JL  lo/jse any Kepone during the four weeks of the experiment (Figure 23; Table




       >•  14).   Temperatures during the experiments ranged between 17.1 and 20.7°C




         (Table 1).







              The concentration of Kepone in the tissues of animals receiving sediment




         suspensions with low Kepone concentrations (ranging between 0.05 and 0.08




       /Xg/1)  did not show much change during the first three weeks of the experiment.




         There was an increase to 0.19  g/g at the end of the fourth week.







              The clams receiving a high concentration of Kepone in the sediment




         suspensions (mean ranging between 0.18 and 0.25/^g/l)  showed very little




         change from the original level during the first three  weeks.  During the




         fourth week, there was an increase to O.SS^g/g.  The  two  samples of oysters




         analyzed at the end of that period had very different  concentrations (0.084




         vs. O.SS^g/g, Table 14) and the lower value was ignored because  it appeared




         unrealistically low.







              Height of the clams used in this experiment ranged between  3 and  5  cm.

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                                                  it
Mu1inia  lateral is —

     A single  experiment  was  conducted with the clam  Mulinia lateralis  (a
common bivalve in  the  lower James River estuary) between August  29  and
September  19,  1978.   The  clams  were exposed to sediment  suspensions
contaminated with  Kepone  for  16 days and subsequently depurated  in
uncontaminated York  River water"" for a little over six days.

     The sediments used  to prepare the suspensions  were  collected  inside
Bailey Creek at  Hopewell  and  had a high concentration of Kepone  (around  14
.g/g).  Consequently;  the  diluted suspensions flowing  over the Mulinia were
much higher  than any  used in  previous experiments of  this type,  0.75  and  1.14
    (Table 12).

     After the first  week of  contamination the Mulinia meats showed a mean
Kepone concentration  of  0.50/cg/g (Table 15; Figure 24).  At the end  of  the
second weekly  period  the mean concentration in the meats was 0.54xu:g/g.
These values represented  concentration factors of 537 and 529, respectively.

     The clams left  in the tray after the second week samples were taken out
were depurated in  uncontaminated York River water for another six days.   At
the end  of that period,  analysis of two samples of the clams showed
concentrations of  0.03 and 0.02//<;g/g, respectively, a reduction of 95%  in
their Kepone content.

     Mean  height of  the  darns used and water temperature and salinity during
this experiment appear in Table 16.

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                                                 Ifr





Field Uptake Experiments





     Two groups of experiments  under  field  conditions  in  the James  River were



conducted with oysters  and  Rangia  to  gather data  for comparison with the



information collected  in  the  laboratory.  In one  group, uncontaminated



animals were held in trays  receiving  contaminated water pumped from creek



tributaries of the James  (Deep;-Creek  and  Skiffes  Creek).  These experiments



were basically identical  to those  conducted in  the  laboratory because the



animals were held in the  same  type of trays and received  similar water  flows.



the second group of experiments  was conducted  in  the James River proper by
s


holding uncontaminated  oysters  in  large wire trays  sitting on the river



bottom.  These experiments  were  designed  to determine  the time period it took



oysters and Rangia to  reach a  steady  state  in  their natural habitat, the



level of contamination  attained  under natural  conditions  and as a check on



results obtained in the laboratory.





Uptake by Oysters at Deep Creek—





     Five experiments  were  completed  in trays  receiving water pumped from



near the bottom of Deep Creek  at Menchville (Table  17).   Three of them



involved exposure periods of  7-8 days.  Two others  involved exposure periods



of 15 and 22 days, respectively.





     During the period  that these  experiments  were  conducted, 12 July-4



August 1978, the concentration  by  weight  of suspended  sediments in  the  water,



determined from a composite sample for each of the  three  weekly periods



included, ranged between  25 and 29 mg/1.  Corresponding Kepone concentrations



in the sediment collected by  centrifugation for the same  periods ranged

-------
between-iDt.06 and O.OSy^g/l.   Kepone  concentration in the sediment suspensions




flowing-,tpver the oysters, computed  from  those  data,  ranged  between 0.001  and




0.002/i-g/d.  They appear  in  parentheses  over  the  corresponding values for




Kepone in oyster meats on Figure  25.







     Oysters exposed  to the  above sediment  suspensions  for  weekly intervals




showed mean Kepone concentrations in their  tissues  ranging  between 0.05  and




0.065^x^/1.  The concentration  factor based on the  concentration of Kepone in




the sed.rment suspensions  ranged between  27,000 and  43,000 (Table 17).







     Oystters exposed  to Deep Creek  water for  two  weeks  (12-28 July) had  a




slight Ly/i higher mean  Kepone  concentration than those exposed  for one week




(Figure,52,5) .  The concentration  factor was  55,555.   Oysters exposed for  three




weeks  CKt July-4 August), however,  showed concentrations of Kepone similar to




those  found in oysters exposed  for  one/week.  Their  concentration factor  was




28,261. orThe relationship between the mean  concentration of Kepone in the




sedimeat:-suspensions  for  the weekly  period  before oysters were analyzed  and




the Keptfcne  concentration  in  oyster  meats agrees very well with the data




collect-ad in the laboratory.  They  fit the  regression line  in Figure 12




adequately.  Thus, these  field data  support the laboratory  finding of a




relationship between  Kepone  in  oysters and  the concentration in suspension




during the  week prior to  sampling.







     Table  18 presents the  concentration factor based on the Kepone




associa-tted  with the sediment particles,  disregarding their  dilution in water,




for thersame groups of oysters  that  appear  in Table 17.  These factors




indicate that the Kepone  in  oyster  meats was  between 71 and 108 percent  of




that fcsuad  on the sediment  particles.  These  figures are much higher than

-------
those recorded in the laboratory experiments, which only ranged between 2 and




27%.







     The concentration of Kepone in the deposits that accumulated in the




trays was similar in all trays for any one weekly period, with one exception




(Table 19).  The concentration in Tray #1, which held oysters, was much




greater than in the other two'trays sampled at the end of the 12-19 July




period.  It was also much greater than that found for any other tray in the




following two weekly periods.







     The weight of the biodeposits and sediments that collected in the trays




holding oysters was between 83 and 87 percent greater than the deposits that




collected in the control trays without oysters.  The difference was observed




for all three weekly periods.







     Water temperature and salinity measurements made once a day at the Deep




Creek experimental site showed the following ranges for each of the three




weekly periods:  12-19 July, 25.0-27.5°C and 11.89-12.95 °/oo; 19-28 July,




27.0-29.5°C and 11.22-12.89 °/oo; 28 July-4 August, 28.2-29.8°C and




11.08-12.43 °/oo (Table 20).







Uptake by Rangia Clams at Skiffes Creek--






     Six experiments were completed in which Rangia cuneata clams in plastic




trays received water pumped up from near the bottom at Skiffes Creek (Fort




Eustis).  Exposure period in four of the experiments ranged between 5.1 and




10.0 days.  Duration of exposure in the other two was 17.0 and 22.1 days.

-------
r                                 »                                         IT*"
\      In experiments of 5 to 10 days duration,  the concentration  of  sediments \




I  suspended in the water flowing over the animals  ranged  between 37 and 46 mg/1




  (Table 21).   The concentration of Kepone in the  suspended  sediments  ranged




  between 0.04 and 0.15/cg/g.  The combination of  these  two  measurements  in




  each experiment resulted in a range of concentrations  of Kepone  in  the




  sediment suspensions between 0.001  and 0.007/,/g/l (Figure  25).






       Rangia held in trays for 17 days between June 2 and 19  had  a mean  Kepone




  concentration of 0.10^g/g at the end of that  period.   This  concentration is




  not too different from that observed for the clams held in trays only during




  the last 10 days of that period (9-19 June"; Expt. No.  3, Table 21).  During




  those ten days both groups of clams were exposed to the same concentration of




  Kepone in the sediment suspension (0.007^/^/1) and concentration factors for




  both groups were based on that value.  Clams exposed for 10  days showed a




  concentration factor of 12,857 and  those exposed for 17 days showed  a factor




  of 15,000.






       Clams held in trays for about three weeks (2-26 June) had a mean Kepone




  concentration of O.ll^g/g in their tissues.  That concentration was only




  slightly higher than the concentration in clams  held in trays for  the last




  five days of the same period (20-26 June; Expt.  No. 4,  Table 21).




  Concentration factor for the clams exposed for 22 days was 36,667 while that




  for clams exposed for five days was 26,667.






       Table 18 presents the concentration factor based on the Kepone




  associated with the sediment particles, disregarding their dilution in  water,




  for the  same group of darns that appear on Table 21.  These  concentration




  factors  show that the Kepone in the clams was between 60 and 150 percent  that

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found on the sediment particles.  As in the case of oysters, these figures




are much higher than those observed in laboratory experiments.







     Both water temperatures and salinity increased progressively during the




period of time included by these studies (Table 16).  Single daily




measurements at Skiffes Creek showed the following ranges, respectively. for C




each of the time periods included in the studies:  17-25 May. 19.7-23.0°C and




0.14-0.55 o/oo; 2-9 June, 24.4-25.3°C and 0.64-1.20 o/oo; 9-19 june)





24.0-26.0°C and 1.07-3.40 °/oo; 20-26 June, 25.7-27.2°C and 3.19-3.74 °/0o •




The increases  in temperature and salinity did not appear to affect the




results obtained.







     Deposits  that accumulated  in the trays during each of the experimental




periods did not differ much in  Kepone concentration (Table 22).




Concentrations recorded in the  control trays without clams (Tray #4) were not




different from those recorded in trays holding clams, except that during the




week of 17-25 May-. Kepone in the tray without clams was higher than  in the




tray with clams.







     Weight of the material that accumulated in the trays was greater in




trays holding clams than in the control tray without clams.  In most cases




the difference was greater than or  approached 50%.







Tray Experiments in the James River—







     Oysters— Salinity at the  three stations selected  for field experiments




was low in May (Table 23).  Therefore, no oysters were  set out until the




first week of June.  Salinity at Deep Water Shoal continued  low through June




and most of July.  For that reason, most of the data on uptake by oysters was

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collected at Wreck Shoal and Point of Shoals (Figure 2).







     The data from oysters held in bottom trays at Wreck Shoal showed no




evidence that length of exposure beyond  the first week affected the




concentration of Kepone in the oyster meats (Table 24; Figure 26).  Oysters




exposed for 52 days had a mean concentration of Kepone very similar to that





in oysters exposed for time per-iods of four, 14 or 24 days (Expt.  No. 1,  5




June-27 July).  Individual values in oyster samples for each of the six




exposure periods ranged between 0.06 and 0.12/xg/g.  These extremes were  not




correlated with length of exposure.  Mean concentration of Kepone in two




other groups of oysters exposed for seven days each on successive weeks (27




July-10 August) was 0.09 and O.lly^g/g.







     There was a similar lack of correlation between Kepone in oyster meats




and  length of exposure after the first week at Point of Shoals.




Concentration of Kepone in individual samples of  oysters ranged between 0.10




and  O.n^g/g (Table 25; Figure 26).  The level reached after 34 days did not




differ greatly from that attained after  10 days.   Two other groups  of oysters




held in trays at Point of Shoals for seven days each on successive  weeks




(following the end of the 34-day experiment mentioned in the  preceding




paragraph) showed a mean concentration of 0.19 and 0.12^^/g, respectively.







     The mean concentration of Kepone was similar in two groups of  oysters




exposed in bottom trays at Deep Water Shoal  for equal time  periods  of seven




days on two successive weeks (27 July-3  August and 3 August-10 August; Table





26,  Figure 26) .







     Ten  pairs of oyster samples collected  from the  trays  and from  the

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natural bottom population on  the same date at  the  same  stations were compared



by regression analysis (Table 27).  The correlation coefficient for the 10



   i^ was 0.764 (Figure 27).
     A t-test comparison of the means  for  individual tray and bottom oyster



samples collected on the same date at  the  same station showed no evidence of



a difference between them  at'Wreck Shoal and Point of Shoals (Figure 28).



Values of the individual samples used  appear in Tables 24 and 25.  The paried



samples collected at Point of Shoals on August 3  (Table 25) were not included



in the comparison because  of the great difference between them (79%).  "t"



value for the Wreck Shoal  data was 0.568 ('d . f . =  17) and for the Point of



Shoals data, it was 0.146  (d.f. = 13).  No  such comparison was made for Deep



Water Shoal because of the few data available.






     The above comparison  indicates that the data for tray and bottom oysters



are comparable and represent the same  population  of oysters.  The variations



found may be explained as  arising from the  natural variations within the



popul at ion.






     Sediments at oyster tray stations — <^ — s
     -                       -•« }
                                            s




     Kepone concentration  in sediments collected  in bottom sediment traps



ranged between 0.02 and 0 .08^
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collected at Wreck Shoal because the  large expanse and thickness of the




oyster beds did not permit our dredge to pick up any in the immediate




vicinity of our tray stations.  No correlation was found between the Kepone




in tray or bottom oysters with Kepone in either the bottom sediments or the




sediments collected in the bottom trays.







     Concentration Factors for Oysters—Concentration factors based on the




Kepone concentration in the sediment  suspensions over the oysters on the




bottom were not computed in these tray  studies.  We did not have the data




required to obtain a good estimate of the suspended load available to the




oysters.







     Data  for  the concentration of Kepone on  sediment particles collected in




the vicinity of the experimental trays  are available.  We can, therefore,




compute the concentration factors based on the Kepone associated with those




sediment particles, without regard to their dilution in the water.  Table 28




presents the computed concentration  factors.







     Most of the concentration factors  were greater than one.  The maximum




for computations based on the Kepone  in trap  sediments was 5.375 and the mean




was 2.745.  The maximum, based on the Kepone  in bottom sediments, was 12.500





and the mean was 5.043.







     Rangia—As was the case with oysters, Kepone  concentration  in  the




tissues of Rangia cuneata was not associated  with  the length  of  the exposure





period.







     Concentration factors for Rangia—No data were  available on  the




concentration  of suspended solids over  Deep Water  Shoal during  these studies.

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Therefore, a concentration  factor  based  on  Kepone  in  the  sediment  suspension




over the clams  in the wire  tray  could  not be  estimated.







     Concentration  factors  based on  the  Kepone  associated  with  sediment




particles, without  regard to  their dilution in  the  water,  for the  Rangia held




in a wire bag at Deep Water Shoal  appear in Table  28.  All values  were




greater than one.   The  average '"f or factors  based on trap  sediments was 1.631




with a range between  1.000  and  2.125.  The  mean for three  factors  based on




bottom sediments was  2.903  with  a  range  between 1.375  and  5.500.







     Size analysis  of  trap  sediments — Ten samples  of  the  sediments which




accumulated  in  sediment  traps at the three  tray stations  were analyzed for




size distribution.   Results appear on Table 30  and  Figure  30.







     Most of the sediments  collected in  the traps  at  all  three  stations fell




in the 8-16  and 16-32   size fractions.  With one exception (Wreck  Shoal, 3




August) the  individual  fractions smaller than 4/<^-  were significantly  lower  in




weight than  the fractions  between  8  and  32/^_ and those >32 .
      Combination of the  fractions  into three major ones,  <8/^,  8-34^ and




 showed  that  the  8-32/x- fraction is  the dominant one in every case (Table 31).




 The other  two  fractions  were  similar in most instances.

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                                  SECTION 4
                                 DISCUSSION
     Study of uptake of Kepone  from sediments in suspension by oysters and




other filter-feeding organisms  is  important to the understanding of the




eventual distribution of Kepone  in the James River estuary as well as its




effect on populations of these  animals exposed to it.  Information thus




obtained can be used to compare  the relative importance of Kepone adsorbed on




sediments and Kepone in solution in the contamination of this important




segment of the James River  fauna.







     Our studies were directed  towards establishment of the extent to which




oysters and other bivalves  are  able to pick up Kepone from contaminated




sediments flowing over them.  A basic assumption in our laboratory




experiments was that whatever amount of Kepone oysters would pick up would




derive from Kepone adsorbed onto the organic and inorganic particulate matter




in the prepared suspensions.  This assumption was based primarily on the fact




that the carrying agent for the  contaminated sediments (York River water)




would be free of Kepone initially  and would not be expected to strip Kepone




from the sediments to any significant extent.







     The above assumption is supported by the statement of Schneider and




Dawson (1978). that in the James River, sediments represent the massive source

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of Kepone available to the biota.  Indications are that the concentrations of




Kepone in solution in the James River are extremely low.  In spite of the




assumption made, the possibility that some Kepone in solution is taken up by




oysters and other filter feeders is not completely disregarded.







     The major observations made from the data collected during these studies
     1.  Oysters and Rangia clams attain a steady state for concentration of




         Kepone in their tissues in at least one week.







     2.  Depuration of oysters  in the laboratory to levels below the FDA




         action limit was accomplished in one week but some Kepone was still




         present after three weeks.







     3.  The concentration of Kepone in the tissues of oysters and Rangia




         increases as the concentration of Kepone in the sediment suspension




         also increases.







     4.  The concentration factor based on the concentration of Kepone in the




         sediment suspension decreases as the concentration of Kepone in the




         sediment suspension increases.







     5.  There was no relationship between the concentration of Kepone in the




         sediments used to prepare the contaminant suspensions and the Kepone




         concentration in oysters or between the concentration factor based




         on the Kepone in the dry sediments and that  in oysters.







     6.  Although many of the values for the concentration factor based on




         Kepone per unit volume of the sediment suspension were very high,

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   f
         the actual concentration of Kepone in laboratory oysters was between



         2  and 28% of that in the dry sediments used to prepare  the



         suspensions, depending on the concentration of the sediment



         particles in the suspension.  In Deep Creek studies,  however,  Kepone



         in oysters was between 71 and 108% that in the sediment particles.




     7.   Oyster feces contained much higher concentrations of  Kepone  than



         pseudofeces or sediments settling out by gravity in the laboratory



         experimental trays.




     8.   The weight of material deposited in t.r ays (ho Id ing oysters or Rangia,
                                                 / ^                  --


         and receiving water  pumped from two tributary creeks  of the  James



         River), exceeded by a wide margin that which deposited by gravity



         alone in trays without animals.




     9.   Data collected in field experiments confirmed results obtained in



         laboratory experiments.




    10.   There are indications that part of the Kepone in the  tissues of



         oysters may derive from Kepone in solution in the James River.



         These and other observations are discussed below.




     Curves for concentration of Kepone in oysters plotted against exposure



time suggest that oysters reach a steady state in the concentration of Kepone
in their tissues within one week. ) Beyond the first week there is no furthog-


increase in concentration in the sediment suspensions remains fairly


constant.  This was shown by the normalized curves presented in the 1976-1977


annual report (Haven and Morales-Alamo, 1977).  Figures 6 and 18 in the


present report also substantiate this conclusion.  The data of Bahner et al .

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um
(1977) for oysters exposed to dissolved Kepone showed they attain equilibri




within 8 to 17 days.







     Two other sets of data support  the conclusion that a steady state is




reached within one week.  Introduction of uncontaminated oysters into trays




holding oysters which had already been exposed to contamination for the




preceding one to three weeks resulted in both groups of oysters having




similar concentrations of Kepone at  the end of one week.  Those results.and




the excellent correlation found between the concentration in oysters and the




mean hourly concentration in the sediment suspensions for the week preceding




s ampling^ show that it is the concentration in the suspension during the week




before sampling that determines the  concentration in the oysters.  Thus,  the




steady state for concentration in oysters must be reached within one week.







     The steady state seems to be achieved within one week regardless of the




concentration in the sediment suspension.  The level at which the steady




state plateau occurs will increase but it will still be attained by the end




of one week.J>As concentration in the sediment suspension increases, the




magnitude of the increase in the steady state level becomes progressively




smaller, in agreement with the relationship illustrated in Figure 12 where




the ratio between Kepone in oyster to Kepone in  the sediment suspension




decreases as the latter increases.\  The experiments conducted at Deep Creek




in which oysters in plastic trays received water pumped from the creek




substantiated the conclusion based on laboratory studies that the steady




state is attained in one week.  They also showed that the concentration of




Kepone present in suspension during  the week previous to sampling determines




the concentration of oysters.  The data collected in studies in which oysters

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were held in wire  trays  on  the  bottom of  the  Janes  River  also  corroborated


the observations made  in the  laboratory and at  the  Deep Creek  pier  concerning


the attainment by  oysters of  the  steady state within one  week  and  the


determinant role of  the  Kepone  concentration  in sediment  suspensions on  the


week before sampling.




     Attainment of a steady state in one  week (or  possibly  sooner)  implies


that oysters are capable of making quick  adjustments to changes  in  the  level


of Kepone in suspension  and that  the effects  of short term  disturbances  that


would increase the levels of  Kepone in suspension  temporarily  would dissipate


quickly  as the levels  in suspension decrease.   The  quick  adjustment to  levels


in suspension are  evident when  oysters are  allowed  to depurate in


uiicontaminated water-




     Bahner et al . (1977) found that oysters  contaminated in Kepone solutions


in the laboratory  depurated themselves of Kepone to non-detectable  levels in


7 to 20  days.) Our laboratory studies showed  that  oysters gijgi lose most of   X — -Jl


their Kepone in one  week but  t-kaJ: — ilT'TTD'ut-d  take a  much longer  period of  time


fjc«r"tfeem to rid themselves  of all their Kepone. \ The rate of depuration,

                     £
however,  wt«4d"" dependjon  water temperature.

     Data  collected  separately by one of us (Haven,  unpublished data)  showed


that contaminated  oysters  held in trays  suspended  from a pier  in the York


River  at Gloucester  Point  did not depurate themselves of Kepone at


temperatures  under 8°C (Table 32, Figure 32).   Oysters from the James  River,


with a Kepone concentration of 0.19 Mg/g, were placed in the York River trays


on  22  January 1976 when the water temperature  was  2.5°C.  Samples of  the


oysters analyzed  one month later, on 18  February,  showed that the oysters

-------
retained practically all of the original Xepone.  During that period of 26

days the water temperature exceeded 8°C only during the last 24 hours and

then only for half that time.



     During the following week (18-26 February), however, the oysters lost

53% of their Kepone at water  temperatures ranging between 7.4 and 10.6°C.

Eighty-two percent of that time water temperature was under 9.0°C and it was
         «       ^
under 8°C only 16 % of the time.  Between 26 February and 12 March (15 days),

when the water temperature was mostly between 9 and 13°C, the oysters reduced

their Kepone by 75%.  The total reduction between 18 February and 12 March

(23 days) was 88%.



     These results show that  oysters are separately able to eliminate Kepone

at temperatures as low as 8°C and that they are definitely active in

depuration of Kepone at 9°C.  In the same study, however, oysters held in

laboratory trays  in water whose temperature had been raised to 15°C depurated

much faster during the period 18-26 February than those held at ambient

temperatures in pier trays (Figure 32).  These data and other data presented

in this report indicate that  oysters are more efficient in depurating

themselves of Kepone at temperatures of 15°C and higher, but that they will s

continue to eliminate Kepone  at lower temepratures until the limiting

temperature of 8°C is reached.  They also showed that there was very little

further reduction in Kepone between 0 .01-0 .02 //g/g regardless of how warm the

water was.


     Bender et al. (1977) have shown that it takes oysters much longer to

depurate at the lower winter  temperatures than during the summer.

Nevertheless, there are indications that oysters lose-Kepone throughout the

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                                                       7
winter months as  shown  in  Figure  3  of  the  same  paper.   The  moving  average

decreases steadily between December 1975 and  April  1976  and between  December

1976 and March  1977.  There is  a  similarity between that decline  in  the

residue levels  of Kepone in oysters during the  winter  and separate

observations made on  the depuration of coliform bacteria by oysters  in the

lower Chesapeake  Bay ./7Haven ej^ _al^- (1977) found  that  when  water  temperatures

are lowered, there  is an inhibition of the pumping  and filtration  activity  in
oysters,^ accompanied by an inhibition of accumulation of coliform bacteria.
                                                                             ^
                                                                             C
but apparently  not  an  inhibition  of  elimination  of  inactivation  of  the  same

bacteria resulting  in  a  net  loss  of  coliform b-acteria  from  the shellfish

during  that  period.^The processes  involved  in elimination  of bacteria  and of

Kepone  by  the oysters  may be  different, but  it appears  that  temperatures which > C«r»*•**•-'

cause oysters to  become  almost  completely  inactive  physiologically  do not

prevent the  loss  of both of  these contaminants.


     Our data also  suggest that the  rate at  which oysters depurate  iCepone  is

not a constant  for  the animal.   Support for  this concentration is provided by

the depuration  rates shown in Figure 8 for  oysters  that  had been exposed  to

contamination for three  weeks and subsequently allowed to depurate  for  one

week.   Even  though  the difference in Kepone  levels  at  the start  of  depuration

was large  (0.25 vs. 0.13 Mg/g), depuration  efficiency  was almost identical in

both groups  of  oysters (77 and  76 percent;  Table 40y.   The rate of elimination SiA/oU*3*X-

and/or  accumulation of Kepone by  the oyster  may  vary  according to exchange

equilibria between  the sediment suspension and the  oyster's tissue  fluids  as

was proposed by Hamelink et  al^. (1971).

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     The laboratory data collected during the studies reported here showed a




high positive correlation between the concentration of Kepone in oysters and




that in the sediment suspensions used to contaminate them.  On the other




hand, no correlation was evident between the Kepone concentration in oysters




and that in the dry sediments used to prepare the contaminant suspensions.




It is thus evident that the extent to which the contaminated particles are




diluted when suspended  in water will be as important in determining the level




of contamination in oysters as would be the concentration of Kepone in the




sediments making up the suspension.







     Although the Kepone adsorbed on the sediments used to prepare the




suspensions was the source of all the Kepone in the suspensions, it could not




be related to the concentration in the oysters because the extent to which




they were diluted in York River water apparently affected the rate of uptake




by oysters.  The data on Table 10 show that as the dilution of the original




dry sediments increased the concentration in oysters decreased.  The less




Kepone  available to the oyster in any given time period,  the less it will




take up, because the animal maintains a continuous flow of the material




through the gut with continuous ingestion and defecation.  In such a process,




time becomes a significant factor and since dilution affects the quantity of




sediments and, consequently,  the quantity of Keponey that the oyster can




ingest  and accumulate in its  gut in a given time interval, it also affects




the quantities of Kepone it will take up into its tissues.







     The positive correlation between Kepone in oysters and Kepone in  a




sediment suspension will probably cease  to exist only at  the point where  the

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concentration of sediments (or total solids) in suspension is so high that it

will cause the oyster to cease pumping.



     The positive correlation cited above justifies the use of a

concentration factor for Kepone in oysters and other filter feeding bivalves

based on the concentration of Kepone per unit volume of the sediment

suspension.  It is also justified because, as was stated earlier, this

concentration factor is analogous to the bioconcentration factor of other

investigators.



     Oysters concentrated Kepone by factors ranging between 1,000 and 55,000

times that found in a unit volume of suspension.  The highest concentration

factor, computed for field data from Deep Creek, was related to the lowest

concentrations of Kepone in the suspensions.  As shown in Figure 13, there is

a negative relationship between this concentration factor and the

concentration of Kepone in the sediment suspensions with the sharpest decline

in  the concentration factor occurring between concentrations of 0.001 and

0.05y^g/1 in the sediment suspension.  The difference between the

concentration factor at a concentration of 0.001/,'g/l in suspension and that

at  a concentration of O.Olpg/1 is 89%.  Between concentrations of 0.01 and

0.05 /Ig/1 , the difference in concentration factor is 71%, while between 0.05

and 0.1 /*'g/l it is only 31%.  At concentrations in suspension higher than

0.1 tig/I the difference between concentration factors for successive
    /
increments of 0.1 decreases at a much slower rate.  It would appear that

oysters are most efficient in concentration of Kepone from sediment

suspensions when the sediment suspensions are extremely dilute.  This is

paradoxical and requires an explanation.

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                                                          1"
     It could be that the oyster  ingests most of  the  particles (and Kepone)

it is able to accommodate in its  gut  (and body tissues) at a very low

concentration of sediments  (and Kepone) in  suspension and relatively very

little more Kepone is picked up from  suspension as the concentration in the

suspension increases beyond that  point.  However, this possiblity is negated

by the following computations made _using values extracted from the regression

line in Figure 12.  At  a Kepone concentration of  0.001 /-(g/l in suspension

oyster meats would have 0.072/'g/g of  Kepone.  Increasing the concentration

by 100 times to 0.1 //g/1, doubles the  Kepone in the meats to 0.16/;'g/g.  To

double the Kepone in the meats once again from, that point we only have to

increase  the Kepone in  the  sediment suspension by a factor of three to

0.3 ^'g/g, resulting in  0.33 /.'g/g  of Kepone  in the meats.  The Kepone in the
   I                        ''
meats can be nearly doubled again to  0.60/?g/g by inreasing the concentration
                                         / '         "
in suspension to 0.5/^g/g,  an  increase by a factor of only 1.7.


     Therefore, an increase in Kepone  in suspension by a  factor of 1.7

between 0.3 and 0.5 /'.g/l accomplishes  the same rate of increase in Kepone in

the oyster meats that required an increase  by a factor of 100 at the lower

concentrations in suspension of 0.001  and 0.1 /(g/1.   Obviously, the oyster is

still capable of ingesting  and assimilating significant amounts of Kepone at

the higher concentrations in suspension included  in our data.


     Some other explanation is required for the reduction in concentration

factor as the concentration in suspension increases.  It  could have resulted

from an increase in elimination of Kepone at the  higher, exposure

concentrations as was suggested for fish by Mayer (1976).  It could also be

an indication of a breakdown in the mechanisms  that account  for accumulation

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of Kepone in the oysters, as the concentration  in the suspensions increases,

due to toxic effects on some physiological process involved in uptake or

elimination as suggested by Hamelink  (1977).

     However, it is interesting to note that the reduction appears to be

related to the fact that the regression line in Figure 12 intersects the

vertical (y) axis above the zero point (at a Kepone value of 0.072.('g/g in

oyster meats).  Consequently,  any reduction in  the value for Kepone in the

sediment suspension below 0.01 /''g/1  (or even below 0.1 /'g/g) results in a
                               /                       /
very large increase in  the concentration  factor because the resultant

decrease in the value for Kepone in  the oyster meats is extremely small.  The

fact that the regression line  crosses  the y-axis where it does may be

considered an artifact  of our  computations.  However, the field data

collected at Deep Creek fit the regression line in Figure 12 adequately and

provide/ supportive evidence that the  line is a good representation of the

true relationship between the  two parameters.   Consequently, the regression

line shows oysters with Kepone in their tissues, as much as 0.07/'vg/g, even
                                                                /
when apparently there is no Kepone in the sediments in suspension, since we

assumed that all Kepone available was  adsorbed  on particulate matter.  We

interpret this to mean  that oysters  are obtaining Kepone from a  source other

than the particulate matter in suspension.  That source is likely to be

Kepone  in solution in the water.  This matter will be discussed  further

b e 1 ow.

     We found no correlation between the  Kepone concentration in the

sediments used to prepare the  contaminant suspensions  (labeled "dry

sediments" in figures and tables) and the concentration of Kepone in oyster

-------
meats.  Neither was there a correlation evident between the concentration of




Kepone in oyster meats and the concentration factor based on the Kepone




concentration in the dry sediments.  This was so because the concentration of




the sediment particles and of the  associated Kepone available to the oysters




was affected by the extent to which  the sediments were diluted in river water




before flowing over the oysters.   Sediments having the same concentration of




Kepone when analyzed dry resulted  in different concentrations in the oyster




meats when diluted to different  concentrations in suspension.  Examples of




this  effect are found in Table  10, particularly for the period 13 May-19 June




1977.







      Consequently, the concentration in suspension of particles (living or




dead) carrying a contaminant should  be taken into account in studies to




determine bioaccumulation  factors  as usually defined in other current




investigations.  The concentration of the prey animal in the experimental




container will have a bearing on how much of the compound the predator will




accumulate in its  tissues, since a higher concentration of the prey animals




will  enhance their capture by the  predator-







      There was also a lack of correlation between Kepone in the sediments




collected in sediment traps  and  that in oysters held in trays at the bottom




of  the James River or in those  collected  from the natural oyster beds.




Correlation coefficient  for  Wreck  Shoal was 0.205 and for Point of Shoals it




was 0.329.  Lack of a correlation  could be due to the fact that the extent to




which these sediments are  diluted  in suspension is not being taken into





account.







      Although the  concentration  factor based on the Kepone concentration  in




the dry  sediments  was not  correlated to the Kepone in the oyster meats.it    T

-------
A
provides information that contrasts markedly with that obtained in the





laboratory and which could be useful in establishing the main source of




Kepone for oysters and other filter feeders.  Kepone concentration in the




meats of oysters approached or exceeded that found in the dry sediments




passing over them in suspension  at Deep Creek.   In the laboratory studies,




Kepone in the meats was usually  no greater than  20% of that found in the




sediment particles.







     It appears  that oysters in  the field were able to extract Kepone from




the suspension more efficiently  than those in the laboratory experiments.in  ?




spite of the fact that the sediments used in the laboratory experiments had a




much higher concentration of Kepone when analyzed dry than those collected




from the Deep Creek water»and that the concentration in suspension was also




much higher in the laboratory studies.  Once again the possibility appears




that some of the Kepone being accumulated by oysters, especially those in the




field, may come  from solution.







     The process of biodeposition by oysters and other filter feeders has




been suggested as an important element in estuarine sedimentary processes




(Haven and Morales-Alamo, 1966a).  It would  likewise be expected to play  an




important role in the distribution of Kepone in  the James River and for  that




reason we conducted several  experiments  in which Kepone in biodeposits was





measured.







     Oyster feces collected  in those experiments contained much higher




concentrations of Kepone  than pseudofeces or sediments settling out from




suspension by gravity.  This difference  is  probably due to selective

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ingestion by oysters of particles associated with Kepone either because of




their small size or their chemical nature (organic).  Between 80-95% of the




particles in oyster feces and pseudofeces are smaller than 3 or 4. and feces  S tc**""




as well as sediments settling out by gravity contain higher levels of organic




carbon than pseudofeces (Haven and Morales-Alamo, 1966a, 1972).  This




difference in organic carbon between pseudofeces and gravity-settling




sediments would explain why the  latter had more Kepone than pseudofeces.




Pseudofeces are composed of particles rejected by oysters and, by selection,




they apparently are lower in the organic carbon than Kepone.







     Although the sediments that settled out by gravity have not been




subjected to such a selection process, they have, however, settled out  Sf ^A~v^'




selectively by size and/or mass.  The larger and heavier particles that




settle out faster probably constitute the bulk of the sediments that settled




in the laboratory trays.  These  larger particles would also contain the least




amount of Kepone of all particles (Nichols and Trotman, 1977).  Therefore,




their Kepone concentration would be  lower than that in the original sediments




used to prepare the suspension.  It  would be lower  than that  in feces because




the two selective processes mentioned favor a higher concentration in feces.







     The concentration of Kepone in  feces, pseudofeces and in  sediments




settling out by gravity was correlated to the concentration in the sediment




suspensions flowing over the animals.  It was also  correlated  to  the




concentration in the dry sediments used to prepare  the suspensions.  This  is




a reflection of the manner in which  oysters take  food  in  from suspension.




The process is a near continuous one with particles being ingested and




passing through the gut with little  interruption.   At  any one  time interval

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the concentration of Kepone in biodeposits is going to be dependent on the




levels of Kepone in the sediment suspension and in the sediment particles




during the same interval.  However, the differential concentration in the




biodeposits and sediments show how the feeding method of the oyster makes the




animal very susceptible to contamination with Kepone and how the sorting




processes during feeding can affect^the distribution of Kepone in the bed




sediments around it.







     Oysters appear to select  for  ingestion fine particles which are




generally associated with high organic contents.  These are the type of




particles most  likely to have  Kepone  adsorbed on their surface.




Consequently, the feces produced by the oysters will reflect the effect of




that selective  ingestion.  Feces should contain higher concentration of




Kepone than pseudofeces and gravity-settling sediments and should concentrate




Kepone by fairly high factors.  That  is precisely what our data show.  The




concentration in the feces ranged  between 15,000 and 133,000 times (mean =




47,578) the concentration in the sediment suspensions and it ranged at




between 62 and  224 % (mean = 114.2%)  of the concentration in the dry




sediments used  to prepare the  suspension.  Not only will oyster feces be rich




in Kepone.but the quantities produced magnify their significance




considerably.






     As measured during the experiments at Deep Creek, the quantities of




material that accumulated in the experimental trays holding oysters were much




greater than those that settled out by gravity  in the trays without animals.




In those trays, between 83 and 87% of the material accumulated can be




attributed to biodeposition.   These figures are almost identical to those

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found in earlier investigations  (Haven  and Morales-Alamo, 1966a).  Therefore,




accumulation of these biodeposits proceeds at a  faster rate than natural




deposition.  Although the Kepone concentration  in  the material deposited in




the trays with animals was not different  from that  in the trays without




animals, the difference  in quantity  of  the material  accumulated would still




make biodeposition a more significant factor than  in the deposition by




gravity in the accumulation  of Kepone in  bottom  sediments.  The lack of a




difference in the concentration  of Kepone in the trays with animals and those




without animals is probably  due  to the  fact that pseudofeces and




gravity-settling sediments would dilute the higher  concentration of Kepone in




the feces and considerably reduce the value for  the  mixture of the three.




The magnitude of biodeposition was illustrated  in  a  previous publication




(Haven  and Morales-Alamo, 1966a) where  it was estimated  that one acre of




oysters 5 to 8 cm in size would  deposit about 405  kg (dry weight) per week of




feces and pseudofeces with a possible maximum of 981 kg/week.  Larger oysters




would produce even greater quantities.







     It has been suggested several times  above  that  oysters in the James




River may be obtaining some  of the Kepone in their  tissues directly from




solution in the water.   This possibility  appears real and deserves further




consideration.  Schneider and Dawson (1978) have suggested that




bioconcentration (i.e.,  uptake directly from solution) is the mechanism which




is  important in determining  the  amount  of Kepone that will he picked up by




the biota of the James River.  They  acknowledge, however, that the amount of




Kepone  available for bioconcentration is  relatively small because it rarely




                                                      and other  filter




              ingest suspended sediments  will have  greater access to the
        C\C pUIlC HV a. 1 J. clU X C  i-U L  U XUUXJUV- tMlU L Cl 1- J.WU  10  1. ^ XQ\_ ± v ^ j__y  01





trfT  )  exceeds 0.008 /fg/U and  that organisms  such as  oysters





      V  feeders which ingest  suspended  sediments  will  have grt

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                                                        11






Kepone available since sediments represent the major source of Kepone in the




James River.






     Although the concentration of Kepone in solution in the James River is




very low, the potential for bioconcentration by oysters could be great enough




to magnify that concentration by a significant factor.  This potential for




bioconcentration should not be ignored until proven to be otherwise.




Therefore, we will use our data and those of others to estimate the fraction




of the total Kepone concentrated by oysters that may derive from Kepone in




solution  in  the James River.






     The  concentrations in sediments collected in the traps set out in the




James River  are comparable to the data collected by Onishi and Ecker (1978)




for suspended sediments at different tidal stages at Burwell Bay in the James




River.  Concentration in  the trap sediments ranged between 0.02 and




0.11 Mg/g.   Concentration in the Burwell Bay suspended sediments ranged




between <0.012 to 0.143.  Therefore, Kepone in the trap sediments appears to




be a close approximation  of  the Kepone in the suspended sediment load.






     The  concentration of Kepone in the sediments centrifuged from water




pumped out of Deep Creek  fell within the above range, toward the higher end.




The similarity between these three sets of data indicates that they are a




good representation of the concentration of Kepone in the suspended sediments




of the James River in the area over the most productive oyster beds and will




be used in the computations  that follow.






     The  mean concentration  of Kepone for all oyster samples (tray and




bottom) collected at Wreck Shoal was 0.08 Mg/g.  The mean for all oyster

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samples from Point of Shoals was 0. 13 i>,g/g.  From  the  regression analysis


presented in Figure 12. we obtained  the complementary regression line for


Kepone in sediment suspensions on Kepone  in oysters.   The line is not plotted


in Figure 12 (it is the complement  of the  line drawn in that figure) but its


equation is:  X = 0.746Y -  0.019, where X  is Kepone in sediment suspension


and Y is the Kepone in oysters-^SoS&ssRjy^the equation  for the mean values jmO^


Kepone in the sediment suspensions  that would correspond to those values in
             Wreck  Shoal  it  would be  0.04^/1  and at Point of Shoals it
                                                      is ion. their    S CffY*^
  would  be  0.08
                i


       The  mean concentration of Kepone in sediments  collected  in  the  bottle


  traps  at  Wreck Shoal was 0.041 /'g/g.   At Point  of Shoals  it was  0.036 /'g/g.


  In  order  for sediments with that concentration  of Kepone  (0.04 /'g/g)  to


  attain a  concentration of 0.04 and 0.08 ('g/l in suspension.


  concentration by weight in the suspension would have to be between 1000  and


  2000 mg/1.   The concentration of suspended solids over the oyster-producing


  areas  of  the James River are usually  only a small fraction of that.



       The  concentration by weight of suspended solids over the principal


  oyster rocks in the James River, between Horse  Head Rock  and  Wreck Shoal
r\

  Rock,  range^on the average between 20 and 40 mg/1 (Nichols,  1972).  At  Deep
             A
  Water  Shoal  the average concentration by weight of solids is  between 60  and


  100 mg/1,  this  being the maximum turbidity area in the estuary  and the  inner


  limit  of  salty water.  Because of the low salinity in that region, oyster


  production  in Deep Water Shoal is low.  Therefore,  we will limit our


  discussion  to the Horse Head to Wreck Shoal area.

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     Based on our data for sediments collected  in  traps  and  those centrifuged


from Deep Creek.we will assume  that 0.08 //g/g  is the highest concentration of
              S                         i

Kepone to be found most frequently over  the  oyster  beds.  Then  at


concentrations of 20-40 mg/1, the concentration of  Kepone in the sediment


suspensions (particulate  and dissolved)  over the oysters would  range between


0.002 and 0.003 /,-rg/l.  These values are  similar to  the levels found in Deep
                /"                 - ' •--

Creek suspended sediments  and those predicted  for  particulate Kepone by


Onishi and Ecker (1978).   Contamination  level  in oysters, corresponding to


those concentrations  in sediment  suspension, would  be 0.07 /'g/p  (as    L dn*a/*

                                                          '            )
extrapolated from the regression  line  in Figure 12).  These  values for


oysters and the sediment  suspensions are very  similar to what was actually


observed at Deep Creek and lend  credibility  to  our  computations.



     The predicted value  of 0.07 /6'g/g  is also  close to the mean obtained  for
                                 /

Wreck Shoal oysters  (0.08  /^g/g) ,  which we  had  indicated  would require a
                          i

concentration of 0.04/^g/l in the  sediment suspension for its attainment.


Hence, we have  a very low concentration  of Kepone  in a sediment suspension


producing a concentration many  times higher  in the  sediment  suspension.   We


see in this an  indication  that  there may be  another source contributing to


the uptake of Kepone  by oysters.   The  computations  that  follow  explore that


possibility further.



     Bahner et  al. (1977)  exposed  oysters  to Kepone dissolved  in water for 28


days at two different concentrations,  0.03 and 0.39//g/l.  Oyster  samples
                                                    t

analyzed at the end  of that period showed  Kepone  concentrations of 0.21  and


2.2/g/g, respectively.   Connecting  those  two  points  in  a  plot  of  the

    /
concentration of Kepone dissolved  in water (in//g/l)  against the

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 corresponding concentration  in  oysters  (in/Ag/g)jwe  obtain  the  line  shown  i



 Figure 31.  This  line will be used  for  other  extrapolations  in  the following



 paragraphs.





      Assuming that  the  calculated  distribution coefficient  between sediments



 and water  is accurate for  field levels  of  solids,  Onishi  and  Ecker (1978)



 predicted  a concentration  of dissolved  Kepone averaging  between 0.0048  and



 0.008l/g/l for  the  James River.  Values for  the  concentration of Kepone  in



 oysters corresponding to those  two  levels  of  dissolved Kepone were



 extrapolated from Figures  31 and they were,  respectively, 0.038 and  0.061



/.'g/g.  Addition  of these values  to the one  obtained earlier  for  oysters



 (0.07/-;g/g) when  the Kepone  concentration  in  sediment  suspensions was
      /

 estimated  at 0.002-0.003 /'g/1  results in a total concentration  in oysters
                          /


 between 0.11 and  0.13 /--'g/g for  the  combined  sources  of Kepone.

                       /



      The  range  0.10-0.13 /'g/g falls well within the  values  reported  by  Bender



 et  al.  (1977)  for James River  oysters.   The  moving average  of the monthly



 samples for the years  1976 and  1977 shows  extremes of  0.8 and 2.0/.-g/g  with  a



 median  of  about 0.16 ,, g/g.   The concentration of Kepone  oysters picked  up



 from the  dissolved  state and from the sediment-bound state,  as  calculated



 above,  is  representative of  the actual  concentrations  found in  oysters



 collected  from  the  James River.



                                                        ^

      Thus, our  calculations  show that between 30 and 46  7* of the Kepone



 concentrated by oysters may  originate by uptake from the dissolved  state.   We



 recommend  that  detailed studies be conducted to establish the relative



 importance of  sediment-bound and dissolved Kepone in uptake by  oysters  and



 other  filter  feeding  organisms.

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                                                            Jtl






     No laboratory uptake studies were conducted with the wedge clam Rang ia




cuneata during the contract period October  1977 to September 1978.  The data




presented in our previous report  for  the  period December 1977 to September




1978 included four uptake studies in  the  laboratory.






     Those earlier studies  suggested  that  the Kepone uptake trends in Rnngia




were similar to those  in oysters.  'As with  oysters, there were indications




that the concentration of Kepone  in Rangia  reaches a steady state in about




one week given a relatively constant  concentration of Kepone in the sediment




suspension.  They  also indicated  that, as  was also the case with oysters, a




steady state in the  concentration of  Kepone  in Kangia clams is attained in




about one week.  A good correlation was obtained between Kepone in Rang ia and




the mean hourly concentration  of  Kepone in  the sediment suspensions during




the week preceding sampling of the animals.






     The information obtained  in  the  laboratory was corroborated by the data




collected during the two types of  field studies with Rangija conducted in




1978.  Clarns held  in plastic  trays receiving water pumped from Skiffes Creek




at Fort Eustis, as well as  those  held in  a  wire bag on the bottom at Deep




Water Shoal, showed  that the  uptake curve  levels off beginning with the first




week.  The Skiffes Creek study included data that  showed that clams exposed




to Kepone in suspended sediments  for  one  week contained almost as much Kepone




as darns in their  second or third week of exposure when the exposure period




of the groups of clams coincided  in the same experiment.






     Another similarity in  the uptake behavior of  oysters and Rangia was the




inverse relationship between  the  concentration factors  for  the animals and




the Kepone concentration in the suspended sediments.  .The differences  in

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slope and Y-intercept between the regression  lines  for oysters and Rangia




would probably be rendered not significant by the associated variation in the




two sets of data.  An inference on  uptake of  Kepone from solution similar to




the one made for oysters could also be made for Rangia based on the




similarity of the data collected.







     As with oysters, we found no evidence of a correlation between Kepone in




Rangia and Kepone on the sediment particles or between the concentration




factor based on  the Kepone adsorbed on the sediment particles and the Kepone




on the particles.







     The results obtained  fron analysis  of the material (biodeposits and




gravity-settling sediments)  that accumulated  in the plastic trays during the




experiments at Skiffes Creek and Deep Creek point^  out another similarity in




the biodepositional activity of oysters  and Rangia.  In both groups of




experiments, the Kepone  concentration in the  control trays without animals




was usually as high as in  the trays holding oysters or clams.  This lack of a




difference has been discussed already in reference  to oysters.







     Discussion  of the data  collected for the wedge clam Rangia cuneata may




be summarized by stating that the activity of Rangia in concentration of




Kepone and its subsequent  biodeposition  parallels that of oysters.  These two




bivalves cover together  a  large portion  of the James River and are found




there in large numbers.  Therefore, the  activity of these animals becomes a




factor of major  significance in retention or  dispersion of Kepone in the





James River.

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     We only conducted one experiment  each with  the clams Macoma balthica and


Mulinia lateralis.  Those experiments  showed  that these animals are also able


to concentrate Kepone with great  efficiency.   The data collected for Macoma


were presented and discussed  in the  previous  report.  No further data were


collected during  the period covered  by the present report.  Mulinia clams


appeared to reach a body tissue equilibrium with Kepone in the sediment


suspensions in one week and,  as did  oysters and  Kangia, they depurated


themselves of Kepone very quickly.   They  lost  almost all their Kepone in less


than one week.  These  few data po i n t £1,*** t o the  ease with which different  t c^t%jV


groups of bivalve molluscs pick up  Kepone and the apparent ease with which


they lose i t .
     Experiments with  the  Asiatic  clam  Corbicula mani lensi s%were hampered by

                                                                             *
the apparent  inability  of  this  clam  to  function "normally" under our


experimental  conditions in the  laboratory.   Further  efforts  to obtain


acceptable data were deemed  unjustified in  view of the  time  and  funding


restrictions.  However,  further investigations  in uptake  and depuration


behavior of this organism  are recommended  since Corbicula is a significant


component of  the freshwater fauna of  the  James River  above  and  below


Hop ewe 11 .



     Several  attempts  were made to study uptake of Kepone by the bloodworm


Glycera dibranchiata but were aborted  when  we  ran into  difficulties with


extraction of the  pesticide from the worm tissues.   Modified procedures used


consumed an extremely  long time for  a  very  few samples  and recovery was only


20-30% at a concentration  of Kepone  of less than  0.2y[-|g/g.
                                                     /

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     It is concluded that  filter-feeding molluscs concentrate Kepone quickly




from the surrounding suspended sediments and water and deposit it in a




concentrated form on the bottom during biodeposition.  Biodeposits initially




deposited on the surface (together with any contaminants such as Kepone) may




be mixed to depths ranging down to 12 cm in several weeks by benthic




invertebrates  (Haven and Morales-AVaroo, 1966b; Kraeuter, Haven and




Morales-Alamo, MS in preparation).   Such buried  substances are then no longer




subject to transport or resuspension, except perhaps in case of a major




storm.
	_ j






nay   C

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